Treatment Sentence Context

Table 1. Analysis of context sentence of 16570 absracts clustered as Treatment

PMID Gene Context Sentence ePubDate
31944312 Identification of the causative viral pathogens of respiratory tract viral infections is important to select an appropriate treatment, save people’s lives, stop the epidemics, and avoid unnecessary use of antibiotics. 2020-03-19
31967265 He received antibiotic treatment, as well as, transfusion, dialysis, hemodynamic, and ventilatory support. […] This case of severe YF with non-fatal outcome emphasizes the importance of adequate syndromic diagnosis, and early and aggressive supportive treatment that can save a patient’s life. 2020-01-23
31981224 In this review, we provide an update on CoV infections and relevant diseases, particularly the host defense against CoV-induced inflammation of lung tissue, as well as the role of the innate immune system in the pathogenesis and clinical treatment. 2020-03-19
31986264 We report the epidemiological, clinical, laboratory, and radiological characteristics and treatment and clinical outcomes of these patients. 2020-03-13
31996494 At present, there is no vaccine or antiviral treatment for human and animal coronavirus, so that identifying the drug treatment options as soon as possible is critical for the response to the 2019-nCoV outbreak. […] Three general methods, which include existing broad-spectrum antiviral drugs using standard assays, screening of a chemical library containing many existing compounds or databases, and the redevelopment of new specific drugs based on the genome and biophysical understanding of individual coronaviruses, are used to discover the potential antiviral treatment of human pathogen coronavirus. […] Lopinavir /Ritonavir, Nucleoside analogues, Neuraminidase inhibitors, Remdesivir, peptide (EK1), abidol, RNA synthesis inhibitors (such as TDF, 3TC), anti-inflammatory drugs (such as hormones and other molecules), Chinese traditional medicine, such ShuFengJieDu Capsules and Lianhuaqingwen Capsule, could be the drug treatment options for 2019-nCoV. 2020-03-18
32017984 Here, we focus on advances in research and development of fast diagnosis methods, as well as potential prophylactics and therapeutics to prevent or treat 2019-nCoV infection. 2020-03-18
32020915 Herein, we present on an overview of the currently available information on the pathogenesis, epidemiology, clinical presentation, diagnosis, and treatment of this virus. 2020-04-13
32022370 The spike protein used for host cell infection shows key nonsynonymous mutations that might hamper the efficacy of previously developed therapeutics but remains a viable target for the development of biologics and macrocyclic peptides. 2020-03-18
32023681 To standardize the diagnosis and treatment of this new infectious disease, operational guidelines for the diagnosis and management of 2019-nCoV infection is accomplished by Peking Union Medical College Hospital. 2020-02-05
32023682 The outbreak of pneumonia caused by the novel coronavirus 2019-nCoV in Wuhan, Hubei province of China, at the end of 2019 shaped tremendous challenges to China’s public health and clinical treatment. 2020-02-05
32023684 Based on current studies, the author summarized the clinical characteristics and evolution of the novel viral pneumonia, and proposed the key points of diagnosis and treatment, the scientific management of both confirmed and suspected cases, and the scientific management of disease prevention and control. 2020-02-05
32026148 Following the latest National recommendations for diagnosis and treatment of pneumonia caused by 2019-nCoV (the 4th edition) and current status of clinical practice in Zhejiang Province, recommendations for the diagnosis and treatment of respiratory infection caused by 2019-nCoV for children were drafted by the National Clinical Research Center for Child Health, the National Children’s Regional Medical Center, Children’s Hospital, Zhejiang University School of Medicine to further standardize the protocol for diagnosis and treatment of respiratory infection in children caused by 2019-nCoV. 2020-02-06
32027631 Although these measures might not prevent the eventual establishment of ongoing, widespread transmission of the virus in the United States, they are being implemented to 1) slow the spread of illness; 2) provide time to better prepare health care systems and the general public to be ready if widespread transmission with substantial associated illness occurs; and 3) better characterize 2019-nCoV infection to guide public health recommendations and the development of medical countermeasures including diagnostics, therapeutics, and vaccines. 2020-02-07
32029004 For it is a never been experienced respiratory disease before and with infection ability widely and quickly, it attracted the world’s attention but without treatment and control manual. […] This guideline includes the guideline methodology, epidemiological characteristics, disease screening and population prevention, diagnosis, treatment and control (including traditional Chinese Medicine), nosocomial infection prevention and control, and disease nursing of the 2019-nCoV. […] Moreover, we also provide a whole process of a successful treatment case of the severe 2019-nCoV infected pneumonia and experience and lessons of hospital rescue for 2019-nCoV infections. 2020-03-19
32031570 Epidemiological, demographic, clinical, laboratory, radiological, and treatment data were collected and analyzed. […] Most patients received antiviral therapy (oseltamivir, 124 [89.9%]), and many received antibacterial therapy (moxifloxacin, 89 [64.4%]; ceftriaxone, 34 [24.6%]; azithromycin, 25 [18.1%]) and glucocorticoid therapy (62 [44.9%]). […] Of the 36 cases in the ICU, 4 (11.1%) received high-flow oxygen therapy, 15 (41.7%) received noninvasive ventilation, and 17 (47.2%) received invasive ventilation (4 were switched to extracorporeal membrane oxygenation). 2020-03-13
32033513 the National Health Commission of the People’s Republic of China publish the guidelines for the diagnosis and treatment of novel coronavirus (2019-nCoV) infection (trial version 5) . 2020-02-08
32034659 This statement is based on the Novel Coronavirus Infection Pneumonia Diagnosis and Treatment Standards (the fourth edition) (National Health Committee) and other previous diagnosis and treatment strategies for pediatric virus infections. […] The present consensus statement summarizes current strategies on diagnosis, treatment, and prevention of 2019-nCoV infection in children. 2020-02-08
32035428 At present, the prevention and treatment of 2019 Novel Coronavirus (2019-nCoV) in China has reached a critical stage. 2020-02-08
32037389 No effective antiviral treatment has been verified thus far. […] All the patients were given antiviral treatment including lopinavir/ritonavir (Kaletra®), arbidol, and Shufeng Jiedu Capsule (SFJDC, a traditional Chinese medicine) and other necessary support care. […] After treatment, three patients gained significant improvement in pneumonia associated symptoms, two of whom were confirmed 2019-nCoV negative and discharged, and one of whom was virus negative at the first test. […] Results obtained in the current study may provide clues for treatment of 2019-nCoV pneumonia. […] The efficacy of antiviral treatment including lopinavir/ritonavir, arbidol, and SFJDC warrants further verification in future study. 2020-03-18
32040667 Oseltamivir is the most widely used neuraminidase inhibitor for treatment of influenza; data suggest that early use is associated with reduced mortality in critically ill patients with influenza. […] Limited existing knowledge highlights the need for data regarding supportive care and adjunctive pharmacologic therapy that is specific for critically ill patients with severe RVI. […] There is a need for more pragmatic and efficient designs to test different therapeutics both individually and in combination. 2020-03-18
32044814 This study aims to investigate its epidemiologic history, and analyze the clinical characteristics, treatment regimens, and prognosis of patients infected with 2019-nCoV during this outbreak. […] Clinical data from 137 2019-nCoV-infected patients admitted to the respiratory departments of the respiratory departments of nine tertiary hospitals in Hubei province from December 30, 2019 to January 24, 2020 were retrospectively collected, including general status, clinical manifestations, laboratory test results, imaging characteristics, and treatment regimens. […] Given the lack of effective drugs, treatment focused on symptomatic and respiratory support. […] Systemic corticosteroid treatment did not show significant benefits. 2020-03-02
32048163 Our results suggest a number of potential diagnosis biomarkers and angiotensin receptor blocker (ARB) drugs for potential repurposing treatment of 2019-nCoV infection. 2020-03-19
32049687 Currently, there is no definite treatment for SSCP although some drugs are under investigation. 2020-02-12
32051071 The perinatal-neonatal departments should cooperate closely and take integrated approaches, and the neonatal intensive care unit should prepare the emergency plan for 2019-nCoV infection as far as possible, so as to ensure the optimal management and treatment of potential victims. 2020-02-19
32051072 During the epidemic of 2019-nCoV, the emergency response plan for the NICU should be based on the actual situation, including diagnosis, isolation, and treatment, as well as available equipment and staffing, and take into account the psychosocial needs of the families and neonatal care staff. 2020-02-19
32051073 In order to further standardize and enhance the clinical management of 2019-nCoV infection in children, reduce the incidence, and decrease the number of severe cases, we have formulated this diagnosis and treatment recommendation according to the recent information at home and abroad. 2020-02-19
32052466 In the absence of treatment for this virus, there is an urgent need to find alternative methods to control the spread of disease. […] Here, we have conducted an online search for all treatment options related to coronavirus infections as well as some RNA-virus infection and we have found that general treatments, coronavirus-specific treatments, and antiviral treatments should be useful in fighting COVID-19. 2020-03-18
32054787 Here, we tested the efficacy of prophylactic and therapeutic remdesivir treatment in a nonhuman primate model of MERS-CoV infection, the rhesus macaque. […] Prophylactic remdesivir treatment initiated 24 h prior to inoculation completely prevented MERS-CoV-induced clinical disease, strongly inhibited MERS-CoV replication in respiratory tissues, and prevented the formation of lung lesions. […] Therapeutic remdesivir treatment initiated 12 h postinoculation also provided a clear clinical benefit, with a reduction in clinical signs, reduced virus replication in the lungs, and decreased presence and severity of lung lesions. […] The data presented here support testing of the efficacy of remdesivir treatment in the context of a MERS clinical trial. 2020-04-01
32057209 We here share the therapeutic experiences of NCP treatment with literature review. 2020-02-14
32060789 With high human-to-human transmission rate (R0), 2019-nCoV has quickly spread in China and other countries, resulting in 34,953 confirmed cases and 725 deaths as of 8 February 2020, thus calling for urgent development of therapeutics and prophylactics. 2020-02-15
32061198 At present, there is no definite and effective treatment for COVID-19. 2020-02-15
32061199 Respiratory support is the most important therapy for SARI patients with respiratory failure. 2020-02-16
32061200 After 3 to 5 days of treatment, 2019-nCoV nucleic acid in a second respiratory sample turned negative in 6 cases. 2020-02-16
32064854 Residents have a high awareness rate of the main symptoms, transmission routes, using of masks, hand washing and treatment information of NCP, while a low awareness rate of the atypical symptoms. 2020-02-17
32064855 Among the 7 patients, 1 case died of (B) aggravation, and the other patients’ condition was effectively controlled after active treatment. 2020-02-17
32065055 Currently, however, there is no specific antiviral treatment or vaccine. […] These results suggest that CR3022 may have the potential to be developed as candidate therapeutics, alone or in combination with other neutralizing antibodies, for the prevention and treatment of 2019-nCoV infections. 2020-03-16
32065348 Historical records on prevention and treatment of infections in CM classics, clinical evidence of CM on the prevention of severe acute respiratory syndrome (SARS) and H1N1 influenza, and CM prevention programs issued by health authorities in China since the COVID-19 outbreak were retrieved from different databases and websites till 12 February, 2020. 2020-04-03
32072919 This guideline is applicable to the health protection requirements of large indoor stadiums which are reconstructed as treatment sites for the Novel Coronavirus Pneumonia (NPC) patients with mild symptoms during the outbreak. 2020-02-19
32074550 The coronavirus disease 2019 (COVID-19) virus is spreading rapidly, and scientists are endeavoring to discover drugs for its efficacious treatment in China. […] Chloroquine phosphate, an old drug for treatment of malaria, is shown to have apparent efficacy and acceptable safety against COVID-19 associated pneumonia in multicenter clinical trials conducted in China. […] The drug is recommended to be included in the next version of the Guidelines for the Prevention, Diagnosis, and Treatment of Pneumonia Caused by COVID-19 issued by the National Health Commission of the People’s Republic of China for treatment of COVID-19 infection in larger populations in the future. 2020-03-18
32074786 As surgeons specialized in the treatment of gastrointestinal tumors, we should always be aware of the prevention for NCP and incorporate this awareness into every detail of clinical practice. […] For malignant tumor, multidisciplinary therapy (MDT) is recommended and non-surgical anti-tumor therapy should be selected with higher priority. […] Neoadjuvant therapy is highly recommended for gastrointestinal cancer at advanced stages that meet the indications of NCCN guideline (gastric cancer T stage ≥ 2/rectal cancer T stage ≥ 3/unresectable colon cancer). […] However, emergency operation still must be performed for patients with acute uncontrolled bleeding, obstruction or after other alternative treatment measures fail. 2020-03-12
32075365 Here we found that treating the patients diagnosed as novel coronavirus pneumonia with chloroquine might improve the success rate of treatment, shorten hospital stay and improve patient outcome. […] In order to guide and regulate the use of chloroquine in patients with novel coronavirus pneumonia, the multicenter collaboration group of Department of Science and Technology of Guangdong Province and Health Commission of Guangdong Province for chloroquine in the treatment of novel coronavirus pneumonia developed this expert consensus after extensive discussion. 2020-02-20
32077440 For patients with lung occupying lesions, the whole process of diagnosis and treatment can not be carried out as usual due to the epidemic. […] All thoracic surgeons in China should work together to develop the proper procedures for the diagnosis and treatment in this special situation, and continuously update the recommendations based on epidemic changes and further understanding of COVID-19. 2020-03-16
32077441 With the spread of COVID-19, the routine clinical diagnosis and treatment for lung cancer patients has been disturbed. […] During the COVID-19 outbreak period, it should be carefully differentiated for fever and respiratory symptoms for lung cancer patients receiving anti-tumor treatment, in order to evaluate the risk of COVID-19. 2020-03-16
32077660 Clinical classification (mild, moderate, severe, and critical) was carried out according to the diagnosis and treatment program of novel coronavirus pneumonia (Trial Fifth Edition) issued by the National Health Commission. […] ALT, AST, ALB and TBil of the severe or critical subgroups were 60.25 (40.88 ~ 68.90) U/L, 37.00 (20.88 ~ 64.45) U/L, 35.75 (28.68 ~ 42.00) g/L, and 20.50 (11.28 ~ 25.00) mmol/L, respectively. Conclusion: The results of this multicenter retrospective study suggests that novel coronavirus pneumonia combined with liver damage is more likely to be caused by adverse drug reactions and systemic inflammation in severe patients receiving medical treatment. […] Therefore, liver function monitoring and evaluation should be strengthened during the treatment of such patients. 目的: 分析新型冠状病毒肺炎病例的临床特征,初步探讨不同临床分型与肝功能损伤的关系。 2020-02-20
32077661 As such, we developed this consensus recommendations on all those high-risk treatments, based on the current evidence as well as the resource limitation in some areas, with the aim to reduce the nosocomial transmission and optimize the treatment for the COVID-19 pneumonia patients. […] Those recommendations include: (1) Standard prevention and protection, and patient isolation; (2) Patient wearing mask during HFNC treatment; (3) Using dual limb ventilator with filters placed at the ventilator outlets, or using heat-moisture exchanger (HME) instead of heated humidification in single limb ventilator with HME placed between exhalation port and mask; avoid using mask with exhalation port on the mask; (4) Placing filter between resuscitator and mask or artificial airway; (5) For spontaneous breathing patients, placing mask for patients during bronchoscopy examination; for patients receiving noninvasive ventilation, using the special mask with bronchoscopy port to perform bronchoscopy; (6) Using sedation and paralytics during intubation, cuff pressure should be maintained between 25-30 cmH(2)O; (7) In-line suction catheter is recommended and it can be used for one week; (8) Dual-limb heated wire circuits are recommended and only changed with visible soiled; (9. […] (11) Avoid unnecessary bronchial hygiene therapy; (12) For patients who need aerosol therapy, dry powder inhaler metered dose inhaler with spacer is recommended for spontaneous breathing patients; while vibrating mesh nebulizer is recommended for ventilated patients and additional filter is recommended to be placed at the expiratory port of ventilation during nebulization. 2020-02-20
32078069 According to the current status, blocking transmission, isolation, protection, and alternative medication are the urgent management strategies against 2019-nCoV. 2020-03-06
32079150 The mean time from illness onset to hospital admission (for treatment and/or isolation) was estimated at 3-4 days without truncation and at 5-9 days when right truncated. 2020-03-20
32080994 Complying with overall requirements of the government and regulations on public health emergences, as well as the clinical features of diagnosis and treatment of dental illness, this paper refers to previous guidelines and studies on the infection prevention and control in dental diagnosis and treatment in China and foreign countries. 2020-02-21
32084675 By summarizing the research progress and guidelines in recent years in the fields of colorectal cancer disease screening, treatment strategies(including early colorectal cancer, locally advanced colorectal cancer, obstructive colorectal cancer, metastatic colorectal cancer and the treatment of patients after neoadjuvant therapy), the choice of medication and time limit for adjuvant therapy, the protective measures for patients undergoing emergency surgery, the re-examination of postoperative patients and the protection of medical staff, etc., authors improve treatment strategies in order to provide more choices for patients to obtain the best treatment under the severe epidemic situation of new coronavirus pneumonia. […] Meanwhile we hope that it can also provide more timely treatment modeling schemes for colleagues. 2020-02-22
32084676 Referring to the “Diagnosis and Treatment Scheme for NCP (Trial Version 4 and 5)” and combining the actual practice situation in our hospital with the “Summary of New Coronavirus Files of Shanghai Renji Hospital”, we summarize how to carry out the clinical practice of colorectal surgery under the situation of the prevention and control of the NCP epidemiology, meanwhile under such situation aiming the procedure of diagnose and treatment for emergency patients with colorectal tumor, we share the experiences of the diagnosis of colorectal tumor, the management of patients with colorectal cancer who are scheduled to be admitted for surgery, the protection of wards, the perioperative management. […] The main points are as follows: (1) Multidisciplinary team (MDT) must be run through the diagnosis and treatment of colorectal cancer. 2020-02-22
32086886 The outbreak of the novel coronavirus has affected the normal diagnosis and treatment services in oral medical institutions across the country. […] Delay of non-emergency dental service will have a potential impact on the experience, cognition, treatment and rehabilitation of patients with oral diseases. […] At the same time, this paper analyzes the possible psychological stress symptoms of patients with different oral diseases, and puts forward suggestions for remote consultation and emergency treatment of dentists. 2020-02-22
32086938 Utilizing the Centers for Disease Control and Prevention (CDC, USA) website, and a comprehensive review of PubMed literature, we obtained information regarding clinical signs and symptoms, treatment and diagnosis, transmission methods, protection methods and risk factors for Middle East Respiratory Syndrome (MERS), Severe Acute Respiratory Syndrome (SARS) and COVID-19. 2020-02-22
32087334 Herein, we describe the epidemic and etiological characteristics of 2019-nCoV, discuss its essential biological features, including tropism and receptor usage, summarize approaches for disease prevention and treatment, and speculate on the transmission route of 2019-nCoV. 2020-03-18
32087621 We will share the treatment experience of severe NCP with the first-line treatment experience. […] In addition, there is up regulation of inflammatory factors in patients with severe NCP, but the effect of renal replacement therapy needs to be further confirmed by clinical research. 2020-02-23
32087622 It is an unavoidable fact that the patients with chronic wounds have to go to the hospital for treatment prescribed by the physician. […] At the same time, we found that quite a few patients preferred going far afield in choosing hospital for treatment due to various reasons. […] During the prevention and control of coronavirus epidemic, this " go far afield" style of seeking medical treatment may increase the exposure risk during travelling. […] Accordingly, we convened 36 wound care clinics in different regions in Shanghai to implement the " Five Measures" encouraging the patients with chronic wounds to seek medical treatment nearby. […] The principle of this operation is that when seeking medical treatment, patients with chronic wounds should try their best to reduce the travel distance as much as possible to minimize the exposure risk during the epidemic period, which will in turn support the campaign of epidemic prevention and control. 2020-02-24
32088333 These measures were motivated by the need to provide effective treatment of patients, and involved consultation with three major groups in policy formulation-public health experts, the government, and the general public. 2020-03-18
32092748 This issue has rapidly reviewed and published articles describing COVID-19, including the drug treatment options for SARS-CoV-2, its clinical characteristics, and therapies involving a combination of Chinese and Western medicine, the efficacy of chloroquine phosphate in the treatment of COVID-19 associated pneumonia according to clinical studies, and reflections on the system of reserve medical supplies for public health emergencies. 2020-03-18
32093211 Meanwhile, it is also crucial to speed up the development of vaccines and drugs for treatment, which will enable us to defeat COVID-19 as soon as possible. 2020-03-22
32096366 The chest CT images of patients with COVID-19 have certain characteristics with dynamic changes, which are of value for monitoring disease progress and clinical treatment. 2020-03-16
32096367 Based on the present expert consensus carried out by National Health Commission and National Administration of Traditional Chinese Medicine, our team summarized and established an effective treatment strategy centered on “Four-Anti and Two-Balance” for clinical practice. […] Meanwhile, integrated multidisciplinarypersonalized treatment was recommended to improve therapeutic effect. […] Early antiviral treatment could alleviate disease severity and prevent illness progression, and we found lopinavir/ritonavir combined with abidol showed antiviraleffects in COVID-19. […] The artificial liver blood purification system could rapidly remove inflammatory mediators and block cytokine storm.Moreover, it also favoredthe balance of fluid, electrolyte and acid-base and thus improved treatment efficacy in critical illness. […] Conservative oxygen therapy was preferred and noninvasive ventilation was not recommended. […] We also integrated Chinese medicine in treatment to promote disease rehabilitation through classification methods of traditional Chinese medicine. […] However, since COVID-19 was a newly emerging disease, more work was warranted to improve strategies of prevention, diagnosis and treatment for COVID-19. 2020-03-16
32096395 The characteristics including high contagiousness, herd susceptibility and clinical phenotype diversity, made a serious influence on people’s daily life and rountine therapy for other diseases. […] In the central epidemic area of COVID-19, Hubei province, especially Wuhan, the clinical specialists of breast diseases should consider all of the following factors comprehensively: the prevention of COVID-19, the diagnosis and treatment of breast diseases and the accessibility of medical resources. […] Besides, we should select the appropriate therapy and optimize treatment process so as to prevent the propagation and cross infection of COVID-19 as well as manage the breast diseases without delay. […] Therefore, we carried out some management proposals of the patients with breast diseases in the central epidemic area during the epidemic of COVID-19 on the basis of conventional treatment guidelines and clinical experiences. 2020-02-25
32096396 After the outbreak of this disease, the overwhelming majority of cities have launched the “first level response” and the regular diagnosis and treatment of cancer patients are greatly affected. […] The epidemic of novel coronavirus pneumonia poses new challenges to diagnosis and treatment of the patients with digestive system malignancies. […] Based on the fully understanding of the characteristics of digestive system tumors, we should change the treatment strategy and adopt more reasonable treatment strategy timely during the epidemic period to minimize the adverse effects of the epidemic of novel coronavirus pneumonia on the treatment. 2020-02-25
32098302 The collaborative efforts of researchers are needed to fill the knowledge gaps about this new virus, to develop the proper diagnostic tools, and effective treatment to combat this infection. 2020-02-26
32098422 The goal of this work is to systematically review and compare between SARS-CoV and SARS-CoV-2 in the context of their virus incubation, originations, diagnosis and treatment methods, genomic and proteomic sequences, and pathogenic mechanisms. 2020-03-23
32098466 According to " the Diagnosis and Treatment of New Coronavirus Pneumonia "(6th edition) of the National Health Commission of the People’s Republic of China, a new guideline for the diagnosis and treatment of 2019 novel coronavirus infection suitable for the military (first trial version) was established. […] Some unique opinions and suggestions are put forward in terms of disease name, diagnosis criteria, antiviral treatment, glucocorticoid application, etc. […] This article will make a proper interpretation in order to understand the guideline better and help guide the diagnosis and treatment of diseases. 2020-02-26
32100486 After treatment, the lesions were shown to be almost absorbed leaving the fibrous lesions. 2020-03-24
32100979 In order to prevent cluster outbreaks, the government strengthened the management and control of personnel mobility, which had a great impact on the examination and treatment of breast cancer patients. […] If necessary, after professional discussion and communication between doctors and patients online or offline, the hospital visiting time should be delayed through seeking alternative treatment schemes, and psychological counseling for patients should be paid attention to at the same time. 2020-02-26
32100980 The outbreak of novel coronavirus pneumonia (NCP) makes the medical treatment of colorectal cancers difficult. […] For metastatic colorectal cancer (CRC) patients, maintenance therapy is the optimal choice. […] Adjuvant chemotherapy should reduce the intensity of treatment and shorten the therapy time. 2020-02-26
32102777 In this report, we provide comprehensive descriptions on data deposition, management, release and utility in 2019nCoVR, laying important foundations in aid of studies on virus classification and origin, genome variation and evolution, fast detection, drug development and pneumonia precision prevention and therapy. 2020-03-12
32104915 Awareness of this may have a guiding significance for the prevention and treatment of the SARS-CoV-2-induced respiratory failure. 2020-03-18
32104917 There is an urgent need for an accurate and rapid test method to quickly identify a large number of infected patients and asymptomatic carriers to prevent virus transmission and assure timely treatment of patients. 2020-04-13
32105052 It has also brought great challenges to the treatment of patients with cancer. […] The selection of surgical procedures and perioperative managements of esophageal cancer require all thoracic surgeons work together to figure out a reasonable system of surgical treatment and emergency response. 2020-02-27
32105680 Principles of management of coronavirus disease 2019 in pregnancy include early isolation, aggressive infection control procedures, oxygen therapy, avoidance of fluid overload, consideration of empiric antibiotics (secondary to bacterial infection risk), laboratory testing for the virus and coinfection, fetal and uterine contraction monitoring, early mechanical ventilation for progressive respiratory failure, individualized delivery planning, and a team-based approach with multispecialty consultations. 2020-04-15
32106216 Although these measures might not prevent widespread transmission of the virus in the United States, they are being implemented to 1) slow the spread of illness; 2) provide time to better prepare state and local health departments, health care systems, businesses, educational organizations, and the general public in the event that widespread transmission occurs; and 3) better characterize COVID-19 to guide public health recommendations and the development and deployment of medical countermeasures, including diagnostics, therapeutics, and vaccines. 2020-03-02
32107909 Objective: To explorethe proper protective measures for pancreaticdiseases treatment during theoutbreak of 2019 coronavirus disease(COVID-19). Method: Clinical data of four cases of patients that suffered COVID-19from February 2(nd), 2020 to February 9(th), 2020 in pancreatic surgery were reviewed.After the first patientscuffednosocomial infection of COVID-19, the general protective measures in our department wereupdated.Only one patient was admitted to each room alone, with no more than one caregiver.The body temperature of care givers was measuredtwice a day.Primary protections were applied to all staff.The floor was sterilized using disinfectant with an effective chlorine concentration of 1000 mg/L.The protective measures for interventional procedures were as follow.Primary protection was applied to the operators ofcentral venipuncture catheter, percutaneous abdominal/pleural drainage, percutaneous retroperitoneal drainage, percutaneous transhepatic cholangial drainage and other surgical procedures with local anesthesiaand epidural anesthesia.Secondary protection was applied to the operators of endoscopic retrograde cholangiopancreatography and surgical procedures with general anesthesia. Results: During Feb 2(nd), 2020 to Feb 9(th), 2020, four patients in our department were diagnosed with COVID-19, of which one was died of COVID-19, two were cured, and one is still in hospital for COVID-19. 2020-02-28
32108351 We aim to summarize reliable evidence of evidence-based medicine for the treatment and prevention of the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) by analyzing all the published studies on the clinical characteristics of patients with SARS-CoV-2. 2020-03-18
32108352 With more and more patients diagnosed, China has carried out more than 100 clinical studies of new coronavirus infection, including antiviral drugs, antimalarial drugs, glucocorticoids, plasma therapy, virus vaccine, and other Western drugs, while Chinese medicine research accounted for half of the studies. […] Although the final results of studies will take a long time to complete, the interim research data may provide some help for the current urgent demand for drug treatment. 2020-03-05
32108459 In addition to supporting the frontline actively, medical workers in general surgery spare no efforts in making good diagnosis and treatment of specialized diseases by optimizing treatment process, providing medical advice online, mastering indications of delayed operation and emergency operation reasonably, etc. […] However, instead of continuing the traditional treatment, a new management system should be developed. […] Based on the characteristics of Budd-Chiari syndrome patients in China and our experience, we divide the patients into ordinary and critical cases, and treatment strategies suitable for the epidemic period of COVID-19 are put forward for reference and discussion by physicians. 2020-02-28
32108460 During the epidemic period, the routine diagnosis and treatment of tumor patients was affected with varying degrees. […] In this special period, we performed the superiority of the multi-disciplinary team of diagnosis and treatment, achieved accurate diagnosis and treatment of patients with hepatobiliary malignant tumors, provided support for these patients with limited medical resources, and helped them to survive during the epidemic period.On the basis of fully understanding the new coronavirus pneumonia, the treatment strategy should be changed timely during the epidemic, and more appropriate treatment methods should be adopted to minimize the adverse effect of the epidemic on tumor treatment. 2020-02-28
32109443 A retrospective analysis was performed on the imaging findings of patients confirmed with COVID-19 pneumonia who had chest CT scanning and treatment after disease onset. […] CT scanning provides important bases for early diagnosis and treatment of NCP. 2020-04-06
32110875 Rapid diagnostics, vaccines and therapeutics are important interventions for the management of the 2019 novel coronavirus (2019-nCoV) outbreak. […] A number of novel compounds as well as therapeutics licensed for other conditions appear to have in vitro efficacy against the 2019-nCoV. 2020-04-11
32111113 The treatment of critically ill patients with coronavirus disease 2019(COVID-19) faces compelling challenges. […] In this issue, we’d like to share our first-line treatment experience in treating COVID-19. […] Nutritional support is the basis of treatment. […] It’s important to establish individual therapy regimens and to evaluate, monitor and adjust dynamically. 2020-02-29
32111114 China has formally included the 2019-nCoV in the statutory notification and control system for infectious diseases according to the Law of the People’s Republic of China on the Prevention and Treatment of Infectious Diseases. […] According to the guidelines on the diagnosis and treatment of COVID-19 (6(th) trial edition), the latest relative literature at home and abroad, the features of the COVID-19, recommendations for the COVID-19 prevention and control issued by the National Health Commission of China, and management experience of diagnosis and treatment in the related disciplines, we put forward recommendations for the medical practices of burn treatment during the outbreak of the COVID-19 in outpatient and emergency treatment, inpatient treatment, operation and ward management, etc. […] We hope these recommendations could benefit the professionals of the same occupation as us and related hospital managers, improve the treatment of burn during the outbreak of the COVID-19, and avoid or reduce the risk of infection of medical staff . 2020-02-29
32112549 Since the outbreak of novel coronavirus pneumonia in December 2019, the diagnosis and treatment of patients with cancer have been facing great challenges. […] Although oncologists are not fighting on the front line to against the epidemic, during this special period, we should not only protect patients, their families and medical staff from the infection of novel Coronavirus, but also minimize the impact of the epidemic on the diagnosis and the treatment of patients with cancer. […] Combining the guidelines for diagnosis and treatment of tumors with our clinical experience, in this epidemic period, we discuss the strategies for diagnosis, treatment, and follow-up of malignant tumors of the digestive system in this article. 2020-02-29
32112886 By Feb 10, 2020, 262 patients were transferred from the hospitals across Beijing to the designated hospitals for special treatment of the COVID-19 infected by Beijing emergency medical service. 2020-04-06
32114744 By the end of February 25, 2020, none of the three patients developed severe 2019-nCoV pneumonia or died(two patients had been cured and discharged, while another one had been transferred to a square cabin hospital for isolation treatment). 2020-03-02
32114747 Corona Virus Disease 2019 (COVID-19) has seriously affected the treatment of patients and social stability. […] At present, some therapies such as interleukin-6 antibody blocker, stem cell therapy, and transfusion of convalescent plasma have been applied to counteract the cytokine storm and have made some progress. 2020-03-02
32115733 The treatment strategy for children with Coronavirus disease (COVID-19) is based on adult experience. 2020-03-16
32117569 While vaccine research should be pursued intensely, there exists today no therapy to treat 2019-nCoV upon infection, despite an urgent need to find options to help these patients and preclude potential death. […] I consider the options of drug repurposing, developing neutralizing monoclonal antibody therapy, and an oligonucleotide strategy targeting the viral RNA genome, emphasizing the promise and pitfalls of these approaches. […] Finally, I advocate for the fastest strategy to develop a treatment now, which could be resistant to any mutations the virus may have in the future. […] Such a treatment could help infected patients before a protective vaccine is developed and widely available in the coming months to year(s). 2020-03-20
32118389 Objective: To analyze the epidemiological history, clinical manifestations, treatment and the short-term prognosis of 31 cases of 2019 novel coronavirus(2019-nCoV) infection in children from six provinces (autonomous region) in northern China. Methods: A retrospective analysis of the epidemiological history, clinical symptoms, signs, laboratory examinations, chest imaging, treatment and the short-term prognosis of 31 cases of 2019-nCoV was conducted. […] After receiving supportive treatment, the viral nucleic acid turned negative in 25 cases within 7-23 days. […] After general treatment, the short-term prognosis is good. 目的: 分析中国北方6省(自治区)儿童2019新型冠状病毒(2019 novel coronavirus, 2019-nCoV)感染者的流行病学史、临床表现、治疗及近期预后。 2020-03-02
32118391 For those patients who can’t completely deoxygenate for a long time after hospitalization, individualized treatment methods and different discharge evaluation criteria should be adopted to ensure the complete cure of patients and prevent recurrencing after discharge from hospital. 2020-03-02
32118394 The diagnosis and treatment of lung cancer patients have been challenged greatly because of extraordinary public health measures since the lung cancer patients are a high-risk population during the COVID-19 outbreak period. 2020-03-02
32118639 The effects of cluster of differentiation 4 (CD4)+ T lymphocytes, inflammatory indicators, and glucocorticoid treatment on viral nucleic acid clearance were analyzed. […] In the 292 confirmed cases, 66 patients recovered after treatment and were included in our study. […] After in-hospital treatment, patients’ inflammatory indicators decreased with improved clinical condition. […] The duration of viral RNA detection from oropharyngeal swabs and fecal samples in the glucocorticoid treatment group was longer than that in the non-glucocorticoid treatment group (15 days vs. […] 8.0 days, respectively; t = 2.550, P = 0.013) and the duration of viral RNA detection in fecal samples in the glucocorticoid treatment group was longer than that in the non-glucocorticoid treatment group (20 days vs. 11 days, respectively; t = 4.631, P < 0.001). […] Because of the delayed clearance of viral RNA in the glucocorticoid treatment group, glucocorticoids are not recommended in the treatment of COVID-19, especially for mild disease. 2020-03-02
32118640 Associated results will be used to evaluate the prognosis and to find the optimal treatment regimens for COVID-19 pneumonia. 2020-03-02
32120458 There was no significant difference in the proportion of ACEI/ARB medication between the critical group and the general group or between non-survivors and survivors (all P>0.05). Conclusion: COVID-19 patients combined with CVD are associated with a higher risk of mortality. 2020-03-02
32120929 Strobilanthes cusia (Nees) Kuntze is a Chinese herbal medicine used in the treatment of respiratory virus infections. 2020-03-03
32125130 In order to achieve the overall victory of the 2019 novel coronavirus disease epidemic in this ‘war’, especially to prevent the disease recurrence from rebounding during the resumption of labor, the government has not loosened any control of personnel mobility, which has obviously affected the normal examination and treatment of lung cancer patients under the influence of this epidemic. […] It is necessary to provide more appropriate individualized treatment recommendations for patients with lung cancer based on the epidemic situation of the patient’s location and in combination with the patient’s own condition. […] Through active prevention of infection, timely conversion of treatment strategies, online and offline joint control, and positive psychological counseling, we significantly hope to help patients with lung cancer to survive this difficult period. 2020-03-03
32125132 During the epidemic of COVID-19, We recommended that patients with advanced NSCLC should be treated as outpatients as possible at the nearest medical center; Patients who need to be hospitalized for antitumor treatment should be excluded from COVID-19 infection; More intensive attention should be paid to identification of COVID-19-related symptoms and adverse reactions caused by the malignancy or antitumor treatments. […] Stronger personal protection should be made for advanced NSCLC patients; An intentional postponing of antitumor treatment should be considered according to patient performance status. […] Treatment strategies should be made according to different types of advanced NSCLC patients and efficacy and toxicity of drugs. 2020-03-03
32125140 The recent outbreak of coronavirus disease 2019 (COVID-19) highlights an urgent need for therapeutics. […] In this brief review, we summarize the broad antiviral activity of niclosamide and highlight its potential clinical use in the treatment of COVID-19. 2020-04-09
32125362 Clinical course was summarized, including requirement for supplemental oxygen and intensive care and use of empirical treatment with lopinavir-ritonavir. […] Some patients required supplemental oxygen and had variable clinical outcomes following treatment with an antiretroviral agent. 2020-03-17
32125642 Currently there is no effective antiviral therapy for SARS-CoV-2 infection, which frequently leads to fatal inflammatory responses and acute lung injury. […] In the absence of a proven clinical FcR blocker, the use of intravenous immunoglobulin to block FcR activation may be a viable option for the urgent treatment of pulmonary inflammation to prevent severe lung injury. […] Such treatment may also be combined with systemic anti-inflammatory drugs or corticosteroids. 2020-03-03
32129518 Therapeutics that may assist to contain its rapid spread and reduce its high mortality rates are urgently needed. […] A tentative suggestion based on existing therapeutics, which would likely be resistant to new coronavirus mutations, is to use available angiotensin receptor 1 (AT1R) blockers, such as losartan, as therapeutics for reducing the aggressiveness and mortality from SARS-CoV-2 virus infections. […] This commentary elaborates on the idea of considering AT1R blockers as tentative treatment for SARS-CoV-2 infections, and proposes a research direction based on datamining of clinical patient records for assessing its feasibility. 2020-03-04
32129583 In heart failure group, the ratio of the expansion of small pulmonary veins was also higher (3/7 vs. 0, P=0.013), and the lung lesions can be significantly improved after effective anti-heart failure treatment. 2020-03-04
32130038 These patients were isolated and obtained treatment. 2020-03-04
32131151 From February 7 to 14, 2020, 246 medical staff were investigated who participated in the treatment of COVID-19 using cluster sampling , and received 230 responses, with a recovery rate of 93.5%. Results: The incidence of anxiety in medical staff was 23.04% (53/230), and the score of SAS was (42.91 ± 10.89). 2020-03-04
32133830 The median of the incubation period of customer cases was 6 days, and the median of the interval between onset and medical treatment of customer cases was 7 days. Conclusion: This was a cluster epidemic of COVID-19, which might be associated with the exposure in the department store. 2020-03-05
32133833 Considering the negative result of nuclear acid testing, this patient was presumptively diagnosed as viral pneumonia and an experiential anti-infection treatment had been prescribed for him. Conclusions: The 2019 novel coronavirus disease (COVID-19) complicates the clinical scenario of pulmonary infiltrates in cancer patients. […] Active anti-infection treatment and surveillance of patient condition should be initiated if infectious disease is considered. 目的: 结合化疗后出现肺内磨玻璃影的淋巴瘤患者的临床特征,分析当前新型冠状病毒肺炎(COVID-19)疫情期间肿瘤患者出现肺内浸润的鉴别诊断和临床处理思路。 2020-03-05
32134278 Hence, the research advancements on SARS-CoV treatment might help scientific community in quick understanding of this virus pathogenesis and develop effective therapeutic/prophylactic agents to treat and prevent this infection. […] The therapeutic potential of monoclonal antibodies has been well recognized in the treatment of many diseases. 2020-03-24
32134861 Currently, there is no definite treatment for COVID-19 although some drugs are under investigation. 2020-03-18
32141058 Due to the current lack of specific treatment and the risk of transmission during the viral incubation period, infection prevention and control of 2019-nCoV are both urgent and critical to global health. 2020-03-11
32141619 The Chinese government has taken emergency measures to control the outbreak and has undertaken initial steps in the diagnosis and treatment of 2019 novel coronavirus infection disease (COVID-19). 2020-03-12
32141624 Isolation and protective procedures would be less effective as more cases accrue, so the optimization of the treatment plan and the development of specific drugs would be of more importance. […] Evidence from the four-phase stringent measures showed that it was significant to ensure early detection, early isolation, early treatment, adequate medical supplies, patients’ being admitted to designated hospitals, and comprehensive therapeutic strategy. 2020-03-24
32142651 A TMPRSS2 inhibitor approved for clinical use blocked entry and might constitute a treatment option. 2020-04-01
32143502 The future of human CoV outbreaks will not only depend on how the viruses will evolve, but will also depend on how we develop efficient prevention and treatment strategies to deal with this continuous threat. 2020-03-09
32145185 This Seminar provides an update on the current knowledge and perspectives on MERS epidemiology, virology, mode of transmission, pathogenesis, diagnosis, clinical features, management, infection control, development of new therapeutics and vaccines, and highlights unanswered questions and priorities for research, improved management, and prevention. 2020-04-13
  1. In the treatment of uterine contraction fatigue, carbetocin or carboprost tromethamine was used more in cesarean section for pregnant women with COVID-19 (1.3±0.6), compared with Non-COVID-19 group (0.5±0.7), the difference was statistically significant (P=0.001). Conclusions: If there is an indication for obstetric surgery or critical illness of COVID-19 in pregnant women, timely termination of pregnancy will not increase the risk of premature birth and asphyxia of the newborn, but it is beneficial to the treatment and rehabilitation of maternal pneumonia.
32145716 Whatever happens, screening and isolating close contacts remains essential except for clinical treatment during the epidemic. 2020-03-08
32145718 The outbreak of coronavirus disease 2019 (COVID-19) has opened a public class on the treatment, prevention and control of infectious diseases for the Chinese citizens. […] In future, when combating with novel infectious diseases and public health emergencies, the response capacity of public health system and treatment capacity of clinical system will be significantly improved, while the situation on insufficient integration of prevention and treatment is bound to be reversed. 2020-03-08
32147496 Recent publications have brought attention to the possible benefit of chloroquine, a broadly used antimalarial drug, in the treatment of patients infected by the novel emerged coronavirus (SARS-CoV-2). 2020-04-15
32147628 Several drugs such as chloroquine, arbidol, remdesivir, and favipiravir are currently undergoing clinical studies to test their efficacy and safety in the treatment of coronavirus disease 2019 (COVID-19) in China; some promising results have been achieved thus far. 2020-03-16
32149769 Medicines for the treatment of 2019-novel coronavirus (2019-nCoV) infections are urgently needed. […] This study aims to repurpose the clinically approved drugs for the treatment of coronavirus disease 2019 (COVID-19) in a 2019-nCoV related coronavirus model. […] The viral RNA yield in cells treated with 10 μmol/L CEP was 15,393-fold lower than in cells without CEP treatment ([6.48 ± 0.02] × 10vs. […] Our results strongly suggest that CEP is a wide-spectrum inhibitor of pan-betacoronavirus, and clinical trial of CEP for treatment of 2019-nCoV infection is warranted. 2020-03-09
32149773 The effectiveness of adjunctive glucocorticoid therapy uses in the management of 2019-nCoV infected patients with severe lower respiratory tract infections is not clear, and warrants further investigation. 2020-03-09
32152082 Therapeutics that target the coronavirus alone might not be able to reverse highly pathogenic infections. 2020-03-10
32152361 We present several distinct features of MERS transmission by employing a comprehensive approach in network research to examine both the traced relationship matrix of infected individuals and their bipartite transmission routes among healthcare facilities visited for treatment. 2020-03-19
32153167 The National Health Commission, PRC has revised the consensus on diagnosis and treatment seven times in a short period of time, indicating the growing understanding of the disease. […] We were trying to find the similarities and differences among them, and to identify clues to the diagnosis of novel coronavirus pneumonia, so as to ensure accurate diagnosis and treatment. 2020-03-10
32153170 The liver function of all patients had recovered within one week after conventional liver protection treatment. Conclusion: COVID-19 combined with liver function injury may be due to the slight elevation of transaminase, mostly around the second week of the disease course. 2020-03-10
32155789 Specific up-to-date and accurate health information (e.g., treatment, local outbreak situation) and particular precautionary measures (e.g., hand hygiene, wearing a mask) were associated with a lower psychological impact of the outbreak and lower levels of stress, anxiety, and depression (p < 0.05). Conclusions: During the initial phase of the COVID-19 outbreak in China, more than half of the respondents rated the psychological impact as moderate-to-severe, and about one-third reported moderate-to-severe anxiety. 2020-03-18
32156101 Our newly developed protocol should be helpful for a first-hand screening of the asymptomatic virus-carriers for further prevention of transmission and early intervention and treatment for the rapidly propagating virus. 2020-03-11
32156648 Following the public-health emergency of international concern (PHEIC) declared by the World Health Organization (WHO) on 30 January 2020 and the recent outbreak caused by 2019 novel coronavirus (2019-nCoV) [officially renamed severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)] in China and 29 other countries, we aimed to summarise the clinical aspects of the novelBetacoronavirus disease (COVID-19) and its possible clinical presentations together with suggested therapeutic algorithms for patients who may require antimicrobial treatment. 2020-04-06
32157264 The KRD regimen was able to convert the chimerism after bone marrow transplant from partial to complete after the first 2 cycles of treatment, showing some activity in this disease. 2020-03-12
32157732 The use of mAb therapeutics has also revealed a “scaffolding” role for FcγR which, in different contexts, may either underpin the therapeutic mAb action such as immune agonism or trigger catastrophic adverse effects. 2020-04-14
32157862 In this case report, we aim to define the chest computed tomography findings of 2019-novel coronavirus associated with pneumonia and its successful resolution after treatment. […] Despite the given treatment, her body temperature rose to 39.2°C and she was referred to our clinic for further evaluation. 2020-04-15
32161940 Surveillance of NLR and lymphocyte subsets is helpful in the early screening of critical illness, diagnosis and treatment of COVID-19. 2020-04-03
32162081 Three of these five had CT abnormality on the first CT scan (at 2 days, 4 days and 9 days, respectively, after onset of symptoms) in the form of patchy ground-glass opacities; all normalised during treatment. 2020-03-12
32162456 The recently emerged 2019 Novel Coronavirus (SARS-CoV-2) and associated COVID-19 disease cause serious or even fatal respiratory tract infection and yet no approved therapeutics or effective treatment is currently available to effectively combat the outbreak. […] This urgent situation is pressing the world to respond with the development of novel vaccine or a small molecule therapeutics for SARS-CoV-2. 2020-03-26
32162699 However, there is no unified standard for the diagnosis and treatment of COVID-19. […] In the retrospective analysis, we report nine cases of COVID-19, describe the history of contact, clinical manifestations, the course of diagnosis and clinical treatment before, during and after treatment. 2020-03-16
32164078 Based on current studies, the author summarized the clinical characteristics and evolution of the novel viral pneumonia, and proposed the key points of diagnosis and treatment, the scientific management of both confirmed and suspected cases, and the scientific management of disease prevention and control. 2020-03-13
32164081 We here share the therapeutic experiences of NCP treatment with literature review. 2020-03-13
32164085 Here we found that treating the patients diagnosed as novel coronavirus pneumonia with chloroquine might improve the success rate of treatment, shorten hospital stay and improve patient outcome. […] In order to guide and regulate the use of chloroquine in patients with novel coronavirus pneumonia, the multicenter collaboration group of Department of Science and Technology of Guangdong Province and Health Commission of Guangdong Province for chloroquine in the treatment of novel coronavirus pneumonia developed this expert consensus after extensive discussion. 2020-03-13
32164086 Respiratory support is the most important therapy for SARI patients with respiratory failure. 2020-03-13
32164092 At present, there is no definite and effective treatment for COVID-19. 2020-03-13
32164424 Similar to outbreaks of other newly identified virus, there is no proven regimen from conventional medicine and most reports managed the patients with lopinavir/ritonavir, ribavirin, beta-interferon, glucocorticoid and supportive treatment with remdesivir undergoing clinical trial. […] In China, Chinese medicine is proposed as a treatment option by national and provincial guidelines with substantial utilization. […] We reviewed the latest national and provincial clinical guidelines, retrospective cohort studies, and case series regarding the treatment of COVID-19 by add-on Chinese medicine. 2020-03-13
32166607 Treatment is essentially supportive; role of antiviral agents is yet to be established. 2020-03-23
32167153 We thought that it is timely to explain the connection between the SARS-CoV, SARS-CoV-2, ACE2 and the rationale for soluble ACE2 as a potential therapy. 2020-03-18
32167524 Epidemiological, demographic, clinical, laboratory, management, treatment, and outcome data were also collected and analyzed. […] Among patients with ARDS, treatment with methylprednisolone decreased the risk of death (HR, 0.38; 95% CI, 0.20-0.72). […] Moreover, treatment with methylprednisolone may be beneficial for patients who develop ARDS. 2020-03-17
32168162 The patient showed improvement both clinically and on computed tomography imaging at discharged after 2 weeks’treatment. 2020-04-16
32169119 In this review, we summarized the latest research progress of the epidemiology, pathogenesis, and clinical characteristics of COVID-19, and discussed the current treatment and scientific advancements to combat the epidemic novel coronavirus. 2020-03-19
32169481 These nine residues can be used to develop therapeutics specific against COVID-19. 2020-04-16
32170865 The purpose of this review is primarily to review the pathogen, clinical features, diagnosis, and treatment of COVID-19, but also to comment briefly on the epidemiology and pathology based on the current evidence. 2020-03-29
32171076 Demographic, clinical, treatment, and laboratory data, including serial samples for viral RNA detection, were extracted from electronic medical records and compared between survivors and non-survivors. 2020-04-03
32171740 In the absence of a known efficient therapy and because of the situation of a public-health emergency, it made sense to investigate the possible effect of chloroquine/hydroxychloroquine against SARS-CoV-2 since this molecule was previously described as a potent inhibitor of most coronaviruses, including SARS-CoV-1. […] Preliminary trials of chloroquine repurposing in the treatment of COVID-19 in China have been encouraging, leading to several new trials. 2020-04-04
32171866 The Lopinavir and Ritonavir Tablets, Chinese medicine, oxygen therapy, and mechanical ventilation were statistically different in the elderly group and the young and middle-aged group, and the P values were all <0.05. 2020-04-01
32171869 Patients who were transferred to intensive care units (ICU) had significantly longer duration of fever as compared to those not in ICU (31 days v.s. 9 days after onset of symptoms, respectively, P <0.0001). […] The clinical progression pattern suggests that early control of viral replication and application of host-directed therapy in later stage is essential to improve the prognosis of CVOID-19. 2020-04-16
32171872 We aimed to compare arbidol and lopinavir/ritonavir(LPV/r) treatment for patients with COVID-19 with LPV/r only. 2020-04-16
32172226 Up to now, clinical features and treatment of patients infected with SARS-CoV-2 have been reported in detail. 2020-04-01
32172228 Overall, potential RT-PCR vulnerabilities include general preanalytical issues such as identification problems, inadequate procedures for collection, handling, transport and storage of the swabs, collection of inappropriate or inadequate material (for quality or volume), presence of interfering substances, manual errors, as well as specific aspects such as sample contamination and testing patients receiving antiretroviral therapy. 2020-04-01
32172669 To standardize the diagnosis and treatment of this new infectious disease, an operational recommendation for the diagnosis and management of SARS-CoV-2 infection is developed by Peking Union Medical College Hospital. 2020-03-17
32173110 As of this time, there is no known effective pharmaceutical treatment, although it is much needed for patient contracting the severe form of the disease. […] The aim of this systematic review was to summarize the evidence regarding chloroquine for the treatment of COVID-19. 2020-03-16
32173241 To date, effective treatment is lacking; however, clinical trials investigating the efficacy of several agents, including remdesivir and chloroquine, are underway in China. 2020-04-09
32173576 Levels of potassium, albumin, lymphocyte were low, but increased persistently after treatment. 2020-03-16
32173725 Refractory COVID-19 patients were more likely to receive oxygen, mechanical ventilation, expectorant, and adjunctive treatment including corticosteroid, antiviral drugs and immune enhancer (P<0.05). 2020-03-16
32174096 Objective: To explore the management strategies for patients with gynecological malignant tumors during the outbreak and transmission of COVID19. Methods: We retrospectively analyzed the clinical characteristics, treatment, and disease outcomes of three patients with gynecological malignancies associated with COVID19 in Renmin Hospital of Wuhan University in January 2020, and proposed management strategies for patients with gynecological tumors under risk of COVID19. Results: Three patients were treated COVID19 based on the national diagnosis and treatment protocol as well as research progress. […] Meanwhile, these patients were appropriately adjusted the treatment plan in accordance with the clinical guidelines for gynecological tumors. […] Pneumonia was cured in 2 patients, and one patient died of COVID-19. Conclusions: Patients with gynecological malignant tumors are high-risk groups prone to COVID-19 infection, and gynecological oncologists need to carry out education, prevention, control and treatment according to specific conditions. […] While actively preventing and controlling COVID-19, the diagnosis and treatment of gynecological malignant tumors should be carried out in an orderly and safe manner. 目的: 在新型冠状病毒肺炎(COVID-19)暴发和传播期间,探讨妇科恶性肿瘤患者的管理策略。 2020-03-16
32176772 Most patients received antiviral therapy (66 [98.5%] of 67 patients) and antibiotic therapy (66 [98.5%] of 67 patients). […] Arbidol treatment showed tendency to improve the discharging rate and decrease the mortality rate. 2020-03-16
32178593 These findings accentuate the unique features of COVID-19 and assist in the development of new therapeutics. 2020-03-19
32178769 Intensive care units will then be at maximum capacity; up to 4000 hospital beds will be needed by mid-April, 2020. 2020-04-16
32179150 This activity is conserved against SARS-Cov-2, thus placing teicoplanin as a potential treatment for patients with this virus. 2020-04-02
32179788 Coronavirus, EBOV, ZIKV, IAV and measles), and also topically for the successful treatment of active lesions (e.g.  2020-03-24
32179908 We report a 55-day-old case with COVID-19 confirmed in China and describe the identification, diagnosis, clinical course, and treatment of the patient, including the disease progression from day 7 to day 11 of illness. 2020-03-17
32180140 We should attach importance to early recognition, early diagnosis, and early treatment of infected children. 2020-03-17
32180175 Three of the parturients are still recovering from their Cesarean delivery and are receiving in-hospital treatment for COVID-19. 2020-04-03
32181903 In severe novel coronavirus pneumonia cases, the number of platelets, their dynamic changes during the treatment, platelet-to-lymphocyte ratio (PLR) were a concern. […] Demographic, clinical, blood routine results, other laboratory results, and treatment data were collected and analyzed. […] Univariate analysis showed that: age, platelet peaks, and PLR at peak platelet were the influencing factors in severe patients, multivariate analysis showed that the PLR value at peak platelet during treatment was an independent influencing factor in severe patients. […] The average hospitalization day of patients with platelet peaks during treatment was longer than those without platelet peaks (P < .05). […] The average age of patients with platelet peaks during treatment was older than those without platelet peaks (P < .05). […] The patients with significantly elevated platelets during treatment had longer average hospitalization days. […] And the higher PLR of patients during treatment had longer average hospitalization days. […] Single-center case series of the 30 hospitalized patients with confirmed COVID-19 in Huizhou Municipal Central Hospital, presumed that the number of platelets and their dynamic changes during the treatment may have a suggestion on the severity and prognosis of the disease. 2020-03-28
32181990 Following a treatment regimen consisting of reduced immunosuppressant use and low dose methylprednisolone-based therapy, the COVID-19 pneumonia in this long-term immunosuppressive patient was successfully recovered. […] This effectively treated case has reference value for the future treatment of other transplant patients with COVID-19 pneumonia. 2020-04-01
32183901 To date, no specific antiviral treatment has proven effective; hence, infected people primarily rely on symptomatic treatment and supportive care. 2020-03-19
32185921 If the diagnosis and treatment of malaria cases as well as the investigation and response of the epidemic foci are not carried out timely, it may endanger patients’lives and cause the possible of secondary transmission, which threatens the achievements of malaria elimination in China. […] Due to the extensive spread and high transmission ability of the COVID-19, there is a possibility of virus infections among malaria cases during the medical care-seeking behaviors and among healthcare professionals during clinical diagnosis and treatment, sample collection and testing and epidemiological surveys. 2020-03-19
32186172 Close monitoring of oxygenation, reducing patients’ oxygen consumption, active psychological intervention, and rapidly dealing with severe hypoxemia events are the key factors for the successful treatment of NIV. […] In addition, active adjuvant therapy is also important, such as correcting coagulation dysfunction, providing proper nutritional support, accurate volume control, and safe individualized blood glucose monitoring and control. 2020-03-18
32186277 Based on the experience from Italy, countries, hospitals and intensive care units should increase their preparedness for a surge of patients with COVID-19 who will require healthcare, and in particular intensive care. 2020-04-02
32186894 OBJECTIVE. The purpose of this study was to describe the clinical manifestations and CT features of coronavirus disease (COVID-19) pneumonia in 15 pregnant women and to provide some initial evidence that can be used for guiding treatment of pregnant women with COVID-19 pneumonia. MATERIALS AND METHODS. We reviewed the clinical data and CT examinations of 15 consecutive pregnant women with COVID-19 pneumonia in our hospital from January 20, 2020, to February 10, 2020. […] Symptoms and laboratory results were analyzed, treatment experiences were summarized, and clinical outcomes were tracked. RESULTS. Eleven patients had successful delivery (10 cesarean deliveries and one vaginal delivery) during the study period, and four patients were still pregnant (three in the second trimester and one in the third trimester) at the end of the study period. 2020-03-18
32186952 However, to date, no licensed antiviral treatment or vaccine exists for MERS and SARS. […] This article highlights ongoing advances in designing vaccines and therapeutics to counter COVID-19 while also focusing on such experiences and advances as made with earlier SARS- and MERS-CoVs, which together could enable efforts to halt this emerging virus infection. 2020-04-01
32187464 No therapeutics have yet been proven effective for the treatment of severe illness caused by SARS-CoV-2. […] Treatment with lopinavir-ritonavir was not associated with a difference from standard care in the time to clinical improvement (hazard ratio for clinical improvement, 1.24; 95% confidence interval [CI], 0.90 to 1.72). […] Lopinavir-ritonavir treatment was stopped early in 13 patients (13.8%) because of adverse events. […] In hospitalized adult patients with severe Covid-19, no benefit was observed with lopinavir-ritonavir treatment beyond standard care. […] Future trials in patients with severe illness may help to confirm or exclude the possibility of a treatment benefit. 2020-04-12
32187887 From the perspective of clinical pediatricians as the first line fighting the epidemic, this paper will discuss the clinical characteristics, prevention and control measures, outcomes, diagnosis, and treatment of pediatric cases. 2020-04-16
32187929 The outbreak of pneumonia caused by the novel coronavirus (2019-nCoV) in Wuhan, Hubei province of China, at the end of 2019 shaped tremendous challenges to China’s public health and clinical treatment. 2020-03-19
32189175 Knowledge of CT characteristics of COVID-19 pneumonia might be helpful to the early diagnosis and treatment of patients, and to control the spread of infection. 2020-03-19
32190290 Here we highlight nine most important research questions concerning virus transmission, asymptomatic and presymptomatic virus shedding, diagnosis, treatment, vaccine development, origin of virus and viral pathogenesis. 2020-03-22
32190904 Here we reported the screening, clinical feathers, and treatment process of a family cluster involving three COVID-19 patients. 2020-03-19
32191691 Singapore adopted a multipronged surveillance strategy that included applying the case definition at medical consults, tracing contacts of patients with laboratory-confirmed COVID-19, enhancing surveillance among different patient groups (all patients with pneumonia, hospitalized patients in intensive care units [ICUs] with possible infectious diseases, primary care patients with influenza-like illness, and deaths from possible infectious etiologies), and allowing clinician discretion (i.e., option to order a test based on clinical suspicion, even if the case definition was not met) to identify COVID-19 patients. 2020-03-20
32191830 Severe forms of the infection, being an indication for treatment in the intensive care unit, comprise acute lung inflammation, ARDS, sepsis and septic shock. […] The article presents basic information about etiology, pathogenesis and diagnostics (with particular emphasis on the importance of tomocomputer imaging), clinical picture, treatment and prevention of the infection. […] Due to the fact that effective causal treatment is not yet available and the number of infections and deaths increases day by day, infection prevention and strict adherence to recommendations of infection control organizations remain the basis for fighting the virus. 2020-03-26
32192278 These measures for early detection and screening of cases should be followed by full efforts to produce research-based evidence by thoroughly analyzing epidemiological, clinical and immunological data, which will facilitate the development of vaccines and therapeutics for COVID-19. 2020-04-08
32192294 By summarizing the research progress and guidelines in recent years in the fields of colorectal cancer disease screening, treatment strategies (including early colorectal cancer, locally advanced colorectal cancer, obstructive colorectal cancer, metastatic colorectal cancer and the treatment of patients after neoadjuvant therapy), the choice of medication and time limit for adjuvant therapy, the protective measures for patients undergoing emergency surgery, the re-examination of postoperative patients and the protection of medical staff, etc., authors improve treatment strategies in order to provide more choices for patients to obtain the best treatment under the severe epidemic situation of new coronavirus pneumonia. […] Meanwhile we hope that it can also provide more timely treatment modeling schemes for colleagues. 2020-03-23
32192296 Although colorectal surgery is not a front-line subject in the fight against the epidemic, but in this special situation, it is a difficult task to provide the highest quality medical services and ensure the orderly clinical work, on the premise of maximizing the protection for patients and their families, health of medical staff, and the safety of wards and hospitals, We summarize how to carry out the clinical practice of colorectal surgery under the situation of the prevention and control of the COVID-19 epidemiology, including the procedures of diagnose and treatment for emergency patients with colorectal tumor, and share the experiences of the diagnosis of colorectal tumor, the management of patients with colorectal cancer who are scheduled to be admitted for surgery, the protection of wards, the perioperative management. […] The main points are as follows: (1) Multidisciplinary team (MDT) must be run through the diagnosis and treatment of colorectal cancer. 2020-03-23
32192297 The outbreak of corona virus disease 2019 (COVID-19) makes the medical treatment of colorectal cancers difficult. […] For metastatic colorectal cancer (CRC) patients, maintenance therapy is the optimal choice. […] Adjuvant chemotherapy should reduce the intensity of treatment and shorten the therapy time. 2020-03-23
32193037 We analyzed the initial and follow-up CT features of patients with disease severity, according to the Guidelines for the Diagnosis and Treatment of New Coronavirus Pneumonia. 2020-04-10
32193831 Treatment modalities were focused on symptomatic and respiratory support. […] Up to February 24, 2020, three patients remained under treatment in ICU, the other five recovered and were discharged home. 2020-03-20
32193905 In this report, we present mild clinical course of her pneumonia that did not require antiviral treatment and serial viral test results from multiple specimens. 2020-03-23
32194034 It is more infectious and fatal than seasonal influenza, and definitive treatment and a vaccine are months away. 2020-04-14
32194944 Among these, the antivirals ledipasvir or velpatasvir are particularly attractive as therapeutics to combat the new coronavirus with minimal side effects, commonly fatigue and headache. 2020-03-24
32195698 Here, the authors review COVID-19 pathogenesis, presentation, diagnosis, and potential therapeutics, with a focus on management of COVID-19-associated respiratory failure. […] The authors draw on literature from other viral epidemics, treatment of acute respiratory distress syndrome, and recent publications on COVID-19, as well as guidelines from major health organizations. 2020-04-16
32195704 So far, actions have been taken including but not limited to nationwide actions and online education regarding special procedures of airway management, oxygen therapy, ventilation support, hemodynamic management, sedation, and analgesia. 2020-04-16
32195705 Timely, but not premature, intubation is crucial to counter a progressively enlarging oxygen debt despite high-flow oxygen therapy and bilevel positive airway pressure ventilation. 2020-04-16
32196032 Identifying antibodies (Abs) that neutralize infectious agents is the first step for developing therapeutics, vaccines, and diagnostic tools for these infectious agents. 2020-03-20
32196083 There is an urgent need to identify safe and effective drugs for treatment. 2020-03-20
32196410 Combined with the published literature, the potential pathogenesis of COVID-19 is inferred, and the treatment recommendations for giving high-doses intravenous immunoglobulin and low-molecular-weight heparin anticoagulant therapy to severe type patients are proposed. 2020-04-07
32196707 All patients were given antiviral therapy (including oseltamivir), oxygen inhalation, and antibiotics. […] One of the five patients had transient hemostatic medication for hemoptysis. 2020-03-31
32197238 This Special Feature highlights the unique circumstances and challenges of cancer treatment amidst this global pandemic, and the importance of organizational structure, preparation, agility, and a shared vision for continuing to provide cancer treatment to patients in the face of uncertainty and rapid change. 2020-04-10
32197787 There is not specific treatment for SARS-CoV-2, which is why the fundamental aspects are to establish adequate prevention measures and support treatment and management of complications. 2020-04-01
32198776 Epidemiological, clinical features, laboratory findings, radiological characteristics, treatment, and clinical outcomes of 135 patients in northeast Chongqing were collected and analyzed in this study. […] All patients received antiviral therapy (135 [100%]) (Kaletra and interferon were both used), antibacterial therapy (59 [43.7%]), and corticosteroids (36 [26.7%]). […] Kaletra and TCM played an important role in the treatment of the viral pneumonia. […] Further studies are required to explore the role of Kaletra and TCM in the treatment of COVID-19. 2020-04-02
32201353 Based on the current published evidence, we systematically summarizes the epidemiology, clinical characteristics, diagnosis, treatment and prevention of knowledge surrounding COVID-19. 2020-04-16
32202256 Hospitalized adult patients with laboratory-confirmed SARS-CoV-2 infection with any one of the following criteria will be eligible to receive lopinavir/ritonavir for 14 days after obtaining written informed consent: (i) respiratory distress with respiratory rate ≥22/min or SpO2 of <94 per cent; (ii) lung parenchymal infiltrates on chest X-ray; (iii) hypotension defined as systolic blood pressure <90 mmHg or need for vasopressor/inotropic medication; (iv) new-onset organ dysfunction; and (v) high-risk groups - age >60 yr, diabetes mellitus, renal failure, chronic lung disease and immunocompromised persons. […] Treatment outcomes amongst initial cases would be useful in providing guidance about the clinical management of patients with COVID-19. 2020-03-23
32202343 Suggested treatment included providing oxygen, inhalations, nutritional support and maintaining fluids and electrolyte balances. 2020-04-14
32202646 Frontline health care workers engaged in direct diagnosis, treatment, and care of patients with COVID-19 were associated with a higher risk of symptoms of depression (OR, 1.52; 95% CI, 1.11-2.09; P = .01), anxiety (OR, 1.57; 95% CI, 1.22-2.02; P < .001), insomnia (OR, 2.97; 95% CI, 1.92-4.60; P < .001), and distress (OR, 1.60; 95% CI, 1.25-2.04; P < .001). […] In this survey of heath care workers in hospitals equipped with fever clinics or wards for patients with COVID-19 in Wuhan and other regions in China, participants reported experiencing psychological burden, especially nurses, women, those in Wuhan, and frontline health care workers directly engaged in the diagnosis, treatment, and care for patients with COVID-19. 2020-04-01
32203189 The outbreak of Coronavirus Disease 2019 (COVID-19) has posed a serious threat to global public health, calling for the development of safe and effective prophylactics and therapeutics against infection of its causative agent, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), also known as 2019 novel coronavirus (2019-nCoV). 2020-03-26
32203711 Available evidence from similar patient populations suggests that carefully selected patients with severe ARDS who do not benefit from conventional treatment might be successfully supported with venovenous ECMO. 2020-04-01
32204411 It may provide references for policy makers to plan and fight against COVID-19 effectively by improving stability of popular feelings and urgently prepare clinical practitioners to deliver corresponding therapy foundations for the risk groups and affected people. 2020-04-01
32204750 With the spread of coronavirus disease 2019 (COVID-19) and growing knowledge of its diagnosis and treatment, it has been clear that children are also susceptible to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). 2020-03-26
32204751 At present there is limited clinical information of the SARS-CoV-2 and there is no specific treatment recommended, although technical guidances and suggestions have been developed and will continue to be updated as additional information becomes available. […] Preventive treatment has an important role to control and avoid the spread of severe respiratory disease, but often is difficult to obtain and sometimes cannot be effective to reduce the risk of deterioration of the underlining lung pathology. […] In order to define an effective and safe treatment for SARS-CoV-2-associated disease, we provide considerations on the actual treatments, on how to avoid complications and the undesirable side effects related to them and to select and apply earlier the most appropriate treatment. […] The final outcome is strictly connected with the ability to apply an appropriate treatment early and to reduce all the complications that can arise during the intensive care admission. 2020-03-26
32204755 After two weeks of treatment, the patient recovered gradually and was discharged. 2020-03-26
32204757 This article reports the diagnosis and treatment of twin girls who were diagnosed with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in Hunan Province, China. […] Both recovered after symptomatic treatment. 2020-03-26
32204758 Newborns with suspected or confirmed COVID-19 should be transferred to designated hospitals for isolation treatment. 2020-03-26
32205092 Development of effective prevention and treatment is an urgent need. 2020-04-16
32205186 Given the lack of specific anti-viral therapies, the current management of severe acute respiratory syndrome coronaviruses (SARS-CoV-2) is mainly supportive, even though several compounds are now under investigation for the treatment of this life-threatening disease. […] COVID-19 pandemic is certainly conditioning the treatment strategy of a complex disorder as rheumatoid arthritis (RA), whose infectious risk is increased compared to the general population because of an overall impairment of immune system typical of autoimmune diseases combined with the iatrogenic effect generated by corticosteroids and immunosuppressive drugs. […] However, the increasing knowledge about the pathophysiology of SARS-CoV-2 infection is leading to consider some anti-rheumatic drugs as potential treatment options for the management of COVID-19. 2020-04-01
32205204 Depending on their clinical presentation, azithromycin was added to the treatment. […] Despite its small sample size our survey shows that hydroxychloroquine treatment is significantly associated with viral load reduction/disappearance in COVID-19 patients and its effect is reinforced by azithromycin. 2020-04-01
32205232 Furthermore, LH treatment resulted in abnormal particle morphology of virion in cells. 2020-04-01
32205349 Scientists are racing towards the development of treatment for COVID-19. 2020-03-24
32207032 However, children less than 3 years old accounted for majority cases and critical cases lied in this age group, which demanded extra attentions during home caring and hospitalization treatment. 2020-03-24
32207377 Due to its high pathogenicity and infectivity and the lack of effective vaccines and therapeutics, live SARS-CoV-2 has to be handled under biosafety level 3 conditions, which has hindered the development of vaccines and therapeutics. […] When tested against the SARS-CoV-2 pseudovirus, SARS-CoV-2 convalescent patient sera showed high neutralizing potency, which underscore its potential as therapeutics. […] Taken together, we established a robust pseudovirus-based neutralization assay for SARS-CoV-2 and are glad to share pseudoviruses and related protocols with the developers of vaccines or therapeutics to fight against this lethal virus. 2020-03-26
32207591 A total of 67 patients diagnosed as COVID-19 by nucleic acid testing were included and divided into 4 groups according to the clinical staging based on Diagnosis and treatment of novel coronavirus pneumonia (Trial version 6). 2020-03-26
32208494 Due to the current development around the COVID-19 pandemic, palliative ch has created a Task Force to provide recommendations for health professionals on the treatment of palliative care patients in the various settings ‒ inpatient and outpatient. 2020-04-02
32208840 Furthermore, he observes the significant abnormality of coagulation function and proposes that the early intravenous immunoglobulin and low molecular weight heparin anticoagulation therapy are very important. […] For severe or critically ill patients, in addition to the respiratory supportive treatment, timely multiorgan evaluation and treatment is very crucial. 2020-04-07
32208987 Because the ACE2 (angiotensin-converting enzyme 2) protein is the receptor that facilitates coronavirus entry into cells, the notion has been popularized that treatment with renin-angiotensin system blockers might increase the risk of developing a severe and fatal severe acute respiratory syndrome coronavirus-2 infection. […] In summary, based on the currently available evidence, treatment with renin-angiotensin system blockers should not be discontinued because of concerns with coronavirus infection. 2020-03-26
32209890 C-reactive protein (CRP) levels were also significantly higher in the death group on admission (109.25 [35.00, 170.28] mg/L vs.3.22 [1.04, 21.80] mg/L, Z = 10.206, P < 0.001) showed no significant improvement after treatment (109.25 [35.0, 170.28] mg/L vs.  2020-03-26
32210741 Altogether, the results presented in this work contribute to gain a deep understanding of the molecular pharmacology of SARS-CoV-2 treatment and validate the use of protease inhibitors against SARS-CoV-2. 2020-03-28
32211816 Clinical laboratory, radiological, and treatment data were collected and analyzed. 2020-03-28
32211844 Epidemiological, clinical and treatment data were analyzed between those older (≥60y) and younger (<60y) patients. 2020-03-26
32211963 We retrospectively reviewed the initial chest CT data of 62 confirmed coronavirus disease 2019 patients (34 men, 28 women; age range 20-91 years old) who did not receive any antiviral treatment between January 21 and February 4, 2020, in Chongqing, China. 2020-03-30
32212378 This commentary seeks to share some key insights relevant to optimizing COVID-19 candidate therapeutics that were learned from attempts to optimize anti-infective posology in settings where quality and timely availability of data is challenging, with particular focus on influenza, including experiences from H5N1 and pH1N1 outbreaks. 2020-03-26
32212779 Cancer patients are more susceptible to coronavirus infection than individuals without cancer as they are in an immunosuppressive state because of the malignancy and anticancer treatment. 2020-04-02
32213260 Available animal and cell line models have suggested that specific therapeutics might be effective in treating Middle East respiratory syndrome (MERS). […] We conducted a systematic review of evidence for treatment with pharmacologic and supportive therapies. […] We developed a protocol and searched 5 databases for studies describing treatment of MERS and deaths in MERS patients. […] One study, at moderate RoB, showed reduced mortality rates in severe MERS patients with extracorporeal membrane oxygenation; no other studies showed a significant lifesaving benefit to any treatment. […] Clinical trials are needed to guide treatment decisions. 2020-03-27
32213700 The COVID-19 virus is severely testing the Italian healthcare system, as the requests for intensive treatment are greater than the real capacity of the system to receive patients. 2020-04-02
32214286 The World Health Organization (WHO) and multiple agencies led by the CDC in the United States have attempted to organize intensive outbreak investigation programs utilizing appropriate preventive measures, evaluation, and treatment. […] These include vaccines, medications Remdesivir and hydroxychloroquine and potentially combination therapy. […] Thus, at this point, the avoidance of the cytokine storm may be the key for the treatment of HCOV-19 infected patients.In China, where there was limited availability of effective modalities to manage COVID-19 several patients were treated with expanded UC-MSCs. […] In this manuscript, we describe the urgent need for various solutions, pathogenesis of coronavirus and the clinical evidence for treatment of COVID-19 with stem cells. 2020-04-01
32215622 Besides satisfying the Koch’s postulates, this readily available hamster model is an important tool for studying transmission, pathogenesis, treatment, and vaccination against SARS-CoV-2. 2020-03-27
32216114 These results provide a foundation for understanding the molecular basis of coronaviral PLPs’ catalytic mechanism and for the screening and design of therapeutics to combat infection by SADS coronavirus. 2020-04-06
32216248 Additionally, they constitute a closed conglomerate since they come to treatment regularly, spending hours in the treatment places, exposed to a possible acquisition of the infection. […] Finally, going to their treatment regularly prevents them from remaining in home isolation and with potential exposure. 2020-03-27
32216653 Outbreaks of infectious etiology, particularly those caused by a novel virus that has no known treatment or vaccine, may result in the interruption of medical care provided to patients with cancer and put them at risk for undertreatment in addition to the risk of being exposed to infection, a life-threatening event among patients with cancer. […] This article describes the approach used to manage patients with cancer during a large-scale Middle East respiratory syndrome-coronavirus hospital outbreak in Saudi Arabia to ensure continuity of care and minimize harm from treatment interruption or acquiring infection. 2020-04-08
32217113 We discuss the latest options in antiviral therapy and vaccine development, including the novel use of chloroquine in the management of COVID-19. 2020-03-28
32217834 Overall, this study characterized the cytokine storm in severe COVID-19 and provides insights into immune therapeutics and vaccine design. 2020-04-13
32218301 The herein-investigated benzimidazole-based derivatives may represent valuable hit compounds, deserving subsequent structural improvements towards more efficient antiviral agents for the treatment of pathologies caused by these human respiratory viruses. 2020-03-30
32218340 At the present, there is no single specific vaccine or efficient antiviral therapy against COVID-19. […] Recently, we showed that intravenous immunoglobulin (IVIg) treatment reduces inflammation of intestinal epithelial cells and eliminates overgrowth of the opportunistic human fungal pathogen Candida albicans in the murine gut. […] Different procedures may be used to remove or inactivate any possible pathogens from the plasma of recovered coronavirus patient derived immune IgG, including solvent/detergent, 60 °C heat-treatment, and nanofiltration. […] Overall, immunotherapy with immune IgG antibodies combined with antiviral drugs may be an alternative treatment against COVID-19 until stronger options such as vaccines are available. 2020-04-07
32219356 During hospitalization, patients with elevated TnT levels had more frequent malignant arrhythmias, and the use of glucocorticoid therapy (37 [71.2%] vs 69 [51.1%]) and mechanical ventilation (41 [59.6%] vs 14 [10.4%]) were higher compared with patients with normal TnT levels. […] Aggressive treatment may be considered for patients at high risk of myocardial injury. 2020-03-31
32219357 She was treated with dobutamine, antiviral drugs (lopinavir/ritonavir), steroids, chloroquine, and medical treatment for heart failure, with progressive clinical and instrumental stabilization. 2020-03-28
32219428 To determine whether convalescent plasma transfusion may be beneficial in the treatment of critically ill patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. […] Case series of 5 critically ill patients with laboratory-confirmed COVID-19 and acute respiratory distress syndrome (ARDS) who met the following criteria: severe pneumonia with rapid progression and continuously high viral load despite antiviral treatment; Pao2/Fio2 <300; and mechanical ventilation. […] All 5 patients (age range, 36-65 years; 2 women) were receiving mechanical ventilation at the time of treatment and all had received antiviral agents and methylprednisolone. […] ARDS resolved in 4 patients at 12 days after transfusion, and 3 patients were weaned from mechanical ventilation within 2 weeks of treatment. […] The limited sample size and study design preclude a definitive statement about the potential effectiveness of this treatment, and these observations require evaluation in clinical trials. 2020-03-31
32219626 Based on the New Diagnosis and Treatment Scheme for Novel Coronavirus Infected Pneumonia (Trial Edition 5), combined with our current clinical treatment experience, we recently proposed a revision of the first edition of “Guidance for maternal and fetal management during pneumonia epidemics of novel coronavirus infection in the Wuhan Tongji Hospital”. […] This article focused on the issues of greatest concern of pregnant women including severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection diagnostic criteria, inspection precautions, drug treatment options, indications and methods of termination of pregnancy, postpartum fever, breastfeeding considerations, mode of mother-to-child transmission, neonatal isolation and advice on neonatal nursing, to provide valuable experience for better management of SARS-CoV-2 infection in pregnant women and newborns. 2020-03-28
32219627 Based on the treatment of severe patients in Wuhan, combined with the treatment practice in Tongji Hospital affiliated to Tongji Medical College, Huazhong University of Science and Technology, this paper puts forward the urgency of further strengthening the construction of public hospitals, discusses the feasible path for promoting the development of public hospitals, so as to meet the growing medical needs of the people, improve the ability to respond to major public health emergencies, and effectively guarantee the safety of people’s lives and the promotion of a healthy China construction. 2020-03-28
32219814 In view of the seriousness of the COVID-19 epidemic, a series of prevention and control measures adopted by the government have restricted the follow-up, diagnosis and treatment of patients by the hospitals, which has a great impact on their mental and physical health. 2020-04-02
32219882 In the absence of specific treatment for this virus, there is an urgent need to learn from the experience and lessons in China. […] To help understand the advantages and limitations of differential treatments, we provide a timely review and discuss the complications and corresponding major treatments, especially controversial ones such as antiviral therapy (remdesivir, ribavirin, and chloroquine), glucocorticoid therapy, extracorporeal support including an artificial liver system, and extracorporeal membrane oxygenation based on available evidence. […] As a result, we suggest that antiviral therapy and organ function support are vital to reduce mortality for mild patients and critical patients, respectively. 2020-04-10
32219885 We also found that the RT-PCR results from several tests at different points were variable from the same patients during the course of diagnosis and treatment of these patients. […] Our results indicate that in addition to the emphasis on RT-PCR testing, clinical indicators such as computed tomography images should also be used not only for diagnosis and treatment but also for isolation, recovery/discharge, and transferring for hospitalized patients clinically diagnosed with COVID-19 during the current epidemic. 2020-04-05
32219995 Efficient obstetric treatment is required, and is key to optimizing the prognosis for both mother and child. 2020-03-28
32220033 Patients in the mild group experienced earlier initiation of antiviral treatment (1.19 ± 0.45 vs 2.65 ± 1.06 days in the severe group, P < 0.001). […] It is recommended that timely antiviral treatment should be initiated to slow the disease progression and improve the prognosis. 2020-03-28
32220112 Anticoagulant therapy mainly with LMWH appears to be associated with better prognosis in severe COVID-19 patients meeting SIC criteria or with markedly elevated D-dimer. 2020-03-28
32220177 This review summarizes the ongoing researches regarding etiology, epidemiology, transmission dynamics, treatment, and prevention and control strategies of the coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), with comparison to severe acute respiratory syndrome coronavirus (SARS-CoV), Middle East respiratory syndrome coronavirus (MERS-CoV) and pandemic H1N1 virus. […] Meanwhile, rapid detection kit for serological monitoring of the virus in general population is expected so as to achieve early detection, early diagnosis, early isolation and early treatment. 2020-04-02
32220178 As biological products have broadly applied in the prevention and treatment of severe epidemic diseases, they are promising in blocking novel coronavirus infection. […] According to the research advances of severe acute respiratory syndrome (SARS) and Middle East respiratory syndrome (MERS), we reviewed the potential application of biological products such as interferon, convalescent plasma, intestinal micro-ecological regulators, vaccines and therapeutic antibodies, etc. , on prevention and treatment of COVID-19. 2020-04-02
32220179 Based on the higher mortality and the higher proportion of critically ill adults in coronavirus disease 2019 (COVID-19) patients with diabetes, good inpatient glycemic control is particularly important in the comprehensive treatment of COVID-19. […] Individualized blood glucose target goals and treatment strategies should be made according to specific circumstances of COVID-19 inpatients with diabetes. […] For mild patients, a strict glycemic control target (fasting plasma glucose (FPG) 4.4-6.1 mmol/L, 2-hour postprandial plasma glucose (2 h PG) 6.1-7.8 mmol/L) are recommended; a target for the glycemic control of common type patients (FPG 6.1-7.8 mmol/L, 2 h PG 7.8-10.0 mmol/L) and subcutaneous insulin deliver therapy are recommended; a target nonfasting blood glucose range of 10.0 mmol or less per liter for severe-type COVID-19 patients, a relatively Less stringent blood glucose control target (FPG 7.8-10.0 mmol/L, 2 h PG 7.8-13.9 mmol/L) for critically ill patients and intravenous insulin infusion therapy are recommended. […] Due to the rapid changes in the condition of some patients, the risk of diabetic ketoacidosis (DKA) or hyperglycemic hyperosmolar status (HHS) maybe occur during the treatment. 2020-04-02
32220276 D-dimer and FDP levels increased progressively when COVID-2019 exacerbated, and 4 patients were diagnosed with definite disseminated intravascular coagulation (DIC). 6 patients received low molecular weight heparin (LMWH) treatment, after which their D-dimer and FDP decreased, but there was no significant improvement in clinical symptoms. 5 patients died finally and the median time from acro-ischemia to death was 12 days. Conclusions: The existence of hypercoagulation status in critical COVID-2019 patients should be monitored closely, and anticoagulation therapy can be considered in selected patients. […] More clinical data is needed to investigate the role of anticoagulation in COVID-2019 treatment. 目的: 总结合并肢端缺血的新型冠状病毒肺炎(COVID-19)患者的临床和凝血参数特征。 2020-03-29
32221523 The widely used reverse transcription PCR (RT-PCR) method has limitations for clinical diagnosis and treatment. 2020-03-29
32221973 In particular, we describe key elements of clinical management, including: safe oxygen therapy; airway management; personal protective equipment; and non-technical aspects of caring for patients diagnosed with coronavirus disease 2019. 2020-04-01
32221983 Because of these protective effects of ACE2 on chronic underlying diseases and ARDS, the development of spike protein-based vaccine and drugs enhancing ACE2 activity may become one of the most promising approaches for the treatment of COVID-19 in the future. 2020-04-05
32222119 The aim is to evaluate pregnant women infected with coronavirus disease 2019 (COVID-19) and provide help for clinical prevention and treatment. 2020-04-10
32222121 To explore the feasibility of surgical treatment for cancer patients complicated with corona virus disease 2019 (COVID-19). […] The inflammation indicators and fever of this patient were effectively controlled and the lung lesions remained stable after active anti-viral treatment, then the radical colorectomy was performed after the viral negative conversion for twice. 2020-04-01
32222466 Here, from the perspective of clinical immunologists, we will discuss the clinical and immunological characteristics of severe patients, and summarize the current evidence and share our experience in anti-inflammation treatment, including glucocorticoids, IL-6 antagonist, JAK inhibitors and choloroquine/hydrocholoroquine, of patients with severe COVID-19 that may have an impaired immune system. 2020-04-16
32222703 COVID-19 patients with ESKD need isolation dialysis, but most of them cannot be handled in time due to limited continuous renal replacement therapy (CRRT) machines. 2020-03-30
32222720 Practical work experience in our spinal outpatient and emergency department during the COVID-19 pandemic is summarized in this article, with combined evidence-based medical evidence to explore a standardized process of diagnosis and treatment for spinal diseases. […] Spine surgeons should collaborate with infection control specialists to avoid cross-infection in hospitals and optimize treatment. 2020-04-07
32222812 The topics were: (1) infection control, (2) laboratory diagnosis and specimens, (3) hemodynamic support, (4) ventilatory support, and (5) COVID-19 therapy. 2020-04-02
32222992 All of these three cases experienced mild illness and recovered soon after the treatment, with the nucleic acid of throat swab turning negative within 14, 11, and 7 days after diagnosis, respectively. 2020-04-15
32223003 This also applies to AD patients on systemic immune-modulating treatment. […] In these days of uncertainty, reallocation of medical resources, curfew, hoarding, and shutdown of normal social life, patients, caregivers and doctors ask questions regarding the continuation of systemic immune-modulating treatment of AD patients. 2020-03-30
32223012 We compared clinical features between patients not requiring admission for clinical reasons or antimicrobials with those assessed as needing either admission or antimicrobial treatment. 2020-04-08
32223665 OBJECTIVE. This study aims to assess correlations of the time from symptom onset to diagnosis and treatment with the time to disease resolution and CT scores as based on findings from sequential chest CT examinations. MATERIALS AND METHODS. Thirty patients with coronavirus disease (COVID-19) confirmed by reverse transcription-polymerase chain reaction analysis underwent chest CT examinations. […] The time from symptom onset to diagnosis and treatment was recorded for each patient, and on the basis of this information, patients with COVID-19 were divided into group 1 (patients for whom this interval was ≤ 3 days) and group 2 (those for whom this interval was > 3 days). […] The CT scores for each group were fitted using a Lorentzian line-shape curve to show the variation tendency during treatment. […] The differences in age, sex, and last CT scores determined before discharge between the two groups were analyzed, and correlations of the time from symptom onset to diagnosis and treatment with the time to disease resolution as well as with the highest CT score also underwent statistical analysis. RESULTS. A total of 25 subjects were enrolled in the study. […] The time from symptom onset to diagnosis and treatment had a positive correlation with the time to disease resolution (r = 0.93; p = 0.000) as well as with the highest CT score (r = 0.83; p = 0.006). CONCLUSION. Timely diagnosis and treatment are key to providing a better prognosis for patients with COVID-19. 2020-03-31
32223840 Objective: To collect the current status and healthcare needs of people living with HIV (PLHIV) in China during the COVID-19 outbreak to inform quick response from government and communities. Methods: During February 5(th) to 10(th) , 2020, a national anonymous survey was conducted using an online questionnaire among PLHIV at least 18 years of age and had started antiretroviral treatment (ART) to collect the information on COVID-19 prevention, HIV-related health services and the needs on psychosocial support. 2020-03-31
32224151 If the last anti-tumour treatment was within 14 days, it significantly increased the risk of developing severe events (HR=4.079, 95%CI 1.086-15.322, P=0.037). 2020-03-31
32224769 The topics were: 1) infection control, 2) laboratory diagnosis and specimens, 3) hemodynamic support, 4) ventilatory support, and 5) COVID-19 therapy. 2020-03-31
32226003 Thanks to the collaboration of experts worldwide, more information about this virus and its infection is reported each day, which allows modifying the recommendations for its prevention and treatment, without forgetting that the ultimate goal is to control this epidemic. 2020-04-03
32226287 Four patients required oxygen therapy but none of them needed machinal ventilation. 2020-04-03
32226288 No specific anti-virus drugs or vaccines are available for the treatment of this sudden and lethal disease. […] The supportive care and non-specific treatment to ameliorate the symptoms of the patient are the only options currently. […] At the top of these conventional therapies, greater than 85% of SARS-CoV-2 infected patients in China are receiving Traditional Chinese Medicine (TCM) treatment. […] In this article, relevant published literatures are thoroughly reviewed and current applications of TCM in the treatment of COVID-19 patients are analyzed. […] Due to the homology in epidemiology, genomics, and pathogenesis of the SARS-CoV-2 and SARS-CoV, and the widely use of TCM in the treatment of SARS-CoV, the clinical evidence showing the beneficial effect of TCM in the treatment of patients with SARS coronaviral infections are discussed. 2020-04-03
32226289 Therapeutic neutralizing antibodies (NAbs) against SARS-CoV-2 will be greatly important therapeutic agents for the treatment of coronavirus disease 2019 (COVID-19). 2020-04-03
32226290 Such knowledge will provide important clues for control of the ongoing epidemic of SARS-CoV-2 infection and treatment of COVID-19. 2020-04-03
32226295 We will cover the basics about the epidemiology, etiology, virology, diagnosis, treatment, prognosis, and prevention of the disease. 2020-04-03
32226695 Following this potential treatment options emerge. […] Other therapeutics to consider that are also directed towards decreased pulmonary pressure include Nifedipine and Phosphodiesterase inhibitors. […] The utilization of medications found to be effective in HAPE, for the treatment of COVID-19, is proposed. 2020-04-02
32227090 The finding of this study explains the high rate of severe cases among COVID-19 patients with basic cardiovascular disease; and these results also perhaps provide important reference to clinical treatment of cardiac injury among severe patients infected by SARS-CoV-2. 2020-03-31
32227123 The levels of peripheral lymphocyte subsets were measured by flow cytometry in 60 hospitalized COVID-19 patients before and after treatment, and their association with clinical characteristics and treatment efficacy was analyzed. […] After treatment, 37 patients (67%) reached clinical response, with an increase of CD8+ T cells and B cells. […] In multivariate analysis, post-treatment decrease of CD8+ T cells and B cells and increase of CD4+/CD8+ ratio were indicated as independent predictors for poor efficacy. […] Peripheral lymphocyte subset alteration was associated with the clinical characteristics and treatment efficacy of COVID-19. […] CD8+ T cells tended to be an independent predictor for COVID-19 severity and treatment efficacy. 2020-03-31
32227197 While influencing national health policies for revising screening criteria, this case also highlighted significant knowledge gaps in diagnosis and treatment and a desperate need for early, widespread, fast and cheap testing for COVID-19. 2020-04-01
32227274 Information on clinical signs and symptoms, medical treatment, virus clearance, and laboratory parameters including interleukin 6 (IL-6) and C-reactive protein were collected. […] Therapeutic regimens of IFN-α + lopinavir/ritonavir and IFN-α + lopinavir/ritonavir + ribavirin might be beneficial for treatment of COVID-19. […] Serum LDH or CK decline may predict a favorable response to treatment of COVID-19 infection. 2020-03-31
32227357 There is no specific treatment available and management is empirical. 2020-03-31
32227493 Confronting the challenge of the outbreak of COVID-19 should sharpen our focus on global drug access as a key issue in antiviral therapy testing. […] The apparent COVID-19 pandemic provides an opportunity to follow dosage guidelines for treatment with ribavirin, test new therapeutic concepts, and conduct controlled testing to apply the scientific rigor required to address the controversy around this mainstay of antiviral therapy. 2020-04-10
32227596 To outline strategies for the treatment of migraine which do not require in-person visits to clinic or the emergency department, and to describe ways that health insurance companies can remove barriers to quality care for migraine. […] We focus on evidence-based treatment where possible, but also describe “real world” strategies which may be tried. 2020-04-13
32227609 The COVID-19 outbreak in Italy is stopping access to elective benign disease treatment and changing the approach to malignant disease as well as the outpatients care of those patients treated for colorectal cancer. 2020-03-31
32227758 During the first 3 weeks of the Covid-19 outbreak in the Seattle area, the most common reasons for admission to the ICU were hypoxemic respiratory failure leading to mechanical ventilation, hypotension requiring vasopressor treatment, or both. 2020-04-16
32228222 We observed that patients receiving ACEI or ARB therapy had a lower rate of severe diseases and a trend toward a lower level of IL-6 in peripheral blood. […] In addition, ACEI or ARB therapy increased CD3 and CD8 T cell counts in peripheral blood and decreased the peak viral load compared to other antihypertensive drugs. 2020-04-02
32228226 The transcriptome dataset of COVID-19 patients would be a valuable resource for clinical guidance on anti-inflammatory medication and understanding the molecular mechansims of host response. 2020-04-02
32228252 In lieu of the fact that many older patients with hypertension or other CVDs are routinely treated with RAAS blockers and statins, new clinical concerns have developed regarding whether these patients are at greater risk for SARS-CoV-2 infection, whether RAAS and statin therapy should be discontinued, and the potential consequences of RAAS blockade to COVID-19-related pathologies such as acute and chronic respiratory disease. 2020-04-16
32228809 These findings might also serve as a practical reference for clinical diagnosis and medical treatment. 2020-04-01
32228825 Therefore, drugs that suppress IL-1 or IL-1R, also used for the treatment of rheumatoid arthritis are to be taken into consideration to treat COVID-19. 2020-04-01
32228827 Finally, the apparently accurate treatment prediction platform (EpiMed) independently developed by the team was used to predict the therapeutic drug. Results: The GSE59185 coronavirus data set was searched and screened in the GEO database, and divided into wt group, ΔE group, Δ3 group, Δ5 group according to different subtypes, and compared with control group. […] The drugs predicted by EpiMed’s apparent precision treatment prediction platform for disease-drug association analysis are mainly TNF-α inhibitors, resveratrol, ritonavir, paeony, retinoic acid, forsythia, and houttuynia cordata. Conclusions: The abnormal activation of multiple inflammatory pathways may be the cause of heart failure in patients after coronavirus infection. 2020-04-01
32229257 The objective of this study is to investigate the short-term effect of risk-adapted treatment strategy on patients with COVID-19. […] We divided these patients into mild, moderate and severe groups, and risk-adapted treatment approaches were given according to the illness severity. […] Risk-adapted treatment strategy was associated with significant clinical manifestations alleviation and clinical imaging recovery. 2020-04-01
32229706 Similarly, two proposed therapeutics for the treatment of COVID-19 infection are Azithromycin and Quercetin, both drugs with significant senolytic activity. […] Therefore, we wish to speculate that the fight against COVID-19 disease should involve testing the hypothesis that senolytics and other anti-aging drugs may have a prominent role in preventing the transmission of the virus, as well as aid in its treatment. […] Thus, we propose that new clinical trials may be warranted, as several senolytic and anti-aging therapeutics are existing FDA-approved drugs, with excellent safety profiles, and would be readily available for drug repurposing efforts. […] As Azithromycin and Doxycycline are both commonly used antibiotics that inhibit viral replication and IL-6 production, we may want to consider this general class of antibiotics that functionally inhibits cellular protein synthesis as a side-effect, for the treatment and prevention of COVID-19 disease. 2020-04-01
32229732 The recorded information includes demographic data, medical history, contact history, potential comorbidities, symptoms, signs, laboratory test results, chest computer tomography scans, and treatment measures. […] In addition, 5 patients with CKD who were undergone regular continuous renal replacement therapy (CRRT) before admission were confirmed infection of SARS-CoV-2 and diagnosed as COVID-19. […] In addition to therapy for COVID-19, CRRT was also applied 3 times weekly during hospitalization for these 5 patients with CKD. […] In the course of treatment, the renal function indicators showed stable state in all 5 patients with CKD, without exacerbation of CKD, and pulmonary inflammation was gradually absorbed. 2020-04-01
32230900 Scientific advancements since the pandemic of severe acute respiratory syndrome (SARS) in 2002~2003 and Middle East respiratory syndrome (MERS) in 2012 have accelerated our understanding of the epidemiology and pathogenesis of SARS-CoV-2 and the development of therapeutics to treat viral infection. […] As no specific therapeutics and vaccines are available for disease control, the epidemic of COVID-19 is posing a great threat for global public health. 2020-04-03
32231345 To develop specific anti-coronavirus therapeutics and prophylactics, the molecular mechanism that underlies viral infection must first be defined. […] Intranasal application of EK1C4 before or after challenge with HCoV-OC43 protected mice from infection, suggesting that EK1C4 could be used for prevention and treatment of infection by the currently circulating SARS-CoV-2 and other emerging SARSr-CoVs. 2020-04-07
32231348 WHO has accelerated research in diagnostics, vaccines and therapeutics for this novel coronavirus. 2020-04-02
32232214 There is still no vaccine or definitive treatment for this virus because its pathogenesis and proliferation pathways are still unknown. 2020-04-04
32232230 As one of the busiest specialised hospitals in the world, the Department of Oral and Maxillofacial Surgery of Peking University School and Hospital of Stomatology summarised the experience with disease prevention and control and clinical recommendations on the examination, diagnosis and treatment processes, clinical management, healthcare personnel protection and disinfection amid the continued spread of the pandemic. 2020-04-02
32232423 The most common procedures related to the examination and treatment of upper aerodigestive tract diseases were reviewed. 2020-04-01
32232432 This paper discusses proposed changes to privacy regulations such as the Health Insurance Portability and Accountability act (HIPAA) designed to let health information seamlessly and frictionlessly flow between the health entities that need to collaborate on treatment of patients and, also, allow it to flow to researchers trying to understand how to limit its impacts. 2020-04-01
32232433 During the period of treatment, the ocular signs and symptoms as well as results of blood tests and reverse transcriptase-polymerase chain reaction (RT-PCR) from nasopharyngeal and conjunctival swabs for SARS-CoV-2 were noted and analyzed. 2020-04-04
32232685 Most of the critically ill patients received high-flow nasal cannula (HFNC) oxygen therapy. […] Among them, 27 (8.4%) patients experienced severe acute respiratory failure including 17 patients (63%) treated with HFNC as first-line therapy, 9 patients (33%) treated with noninvasive ventilation (NIV) and one patient (4%) treated with invasive ventilation. […] HFNC failure was defined by the need of NIV or intubation as rescue therapy. […] After initiation of NIV as rescue therapy among the 7 patients with HFNC failure, PaO2/FiO2 significantly improved after 1-2 h of NIV [median 172 (150-208) mmHg vs. […] However, two out of seven (29%) patients with NIV as rescue therapy ultimately received intubation. 2020-04-03
32233013 Demographic data, medical history, symptoms and signs, laboratory findings, chest computed tomography (CT) as well the treatment measures were collected and analysed. 2020-04-08
32233018 Targeting the overexpression of Il-6 effects with a monoclonal antibody against IL-6 receptor or using Janus Kinase inhibitors may be particularly helpful for treatment of Covid-19 pneumonia in diabetes. 2020-04-14
32233064 It is prudent to stop non-cancer procedures and prioritize urgent cancer treatment. 2020-04-02
32233561 The absence of specific therapeutic treatment or effective vaccine against COVID-19 call for other avenues of the prevention and control measures. 2020-04-09
32233563 More rigorous prevention measures and better treatment of patients are needed to control its further spread, e.g., increasing available hospital beds, shortening the period from symptom onset to isolation of patients, quarantining and isolating the suspected cases as well as all confirmed patients. 2020-04-09
32233641 Currently, no effective medical treatment exists to combat this disease. […] Traditional Chinese herbal medicines (CHM) have unique roles in the treatment of viral infections. 2020-04-13
32233642 All the patients received standardized treatment. 2020-04-13
32233816 Antibiotic and antiviral treatment was initiated. 2020-04-16
32233973 Satisfactory outcome was observed in one mild case and one severe case of COVID-19 pneumonia after the use of the online/offline multidisciplinary quarantine observation form, online monitoring, and classified diagnosis and treatment, as well as strict compliance with quarantine measures. […] The multidisciplinary self-quarantine model provides early judgment, identification, and treatment of disease, improves compliance with early rehabilitation, increases confidence in recovery, and enhances self-management capabilities. […] The application of this new management model is worthy of being promoted in our specialized treatment facilities and in countries with severe epidemics. 2020-04-02
32234126 The current etiological test of COVID-19 cost long time, and have high false negative rate, may resulting delay the measures of disease treatment and prevention. 2020-04-02
32234131 After 3 to 5 days of treatment, 2019-nCoV nucleic acid in a second respiratory sample turned negative in 6 cases. 2020-04-03
32234465 Here we scrutinise a series of available studies by global scientists on the clinical manifestations, detection methods and treatment options for the disease caused by SARS-CoV-2, named coronavirus disease 2019 (COVID-19), and also propose potential strategies for preventing the infection. 2020-04-15
32234466 Intensive research on the newly emerged SARS-CoV-2 is urgently needed to elucidate the pathogenic mechanisms and epidemiological characteristics and to identify potential drug targets, which will contribute to the development of effective prevention and treatment strategies. 2020-04-11
32234467 Therefore, the treatment of cytokine storm has become an important part of rescuing severe patients. […] If it can block the signal transduction pathway of IL-6, it is expected to become a new method for the treatment of severe patients. 2020-04-09
32234468 In addition, registered trials investigating treatment options for COVID-19 infection are listed. 2020-04-09
32235161 A third survey collected current practice of PIBD treatment. […] Eight PIBD children had COVID-19 globally, all with mild infection without needing hospitalization despite treatment with immunomodulators and/or biologics. […] No cases have been reported in China and South Korea but biologic treatment has been delayed in 79 children, of whom 17 (22%) had exacerbation of their IBD. […] Among the Porto group members, face-to-face appointments were often replaced by remote consultations but almost all did not change current IBD treatment. 2020-04-08
32235486 Data on treatment options were limited. 2020-04-02
32235575 Although no vaccines have been discovered yet, a series of containment measures have been implemented by various governments, especially in China, in the effort to prevent further outbreak, whilst various medical treatment approaches have been used to successfully treat infected patients. […] On the basis of current studies, it would appear that the combined antiviral treatment has shown the highest success rate. […] This review aims to critically summarize the most recent advances in understanding the coronavirus, as well as the strategies in prevention and treatment. 2020-04-08
32236089 The entire healthcare system had to respond promptly in a very short time to an exponential growth of the number of subjects affected by COVID-19 (Coronavirus disease 2019) with the need of semi-intensive and intensive care units. 2020-04-02
32236624 In the present review, we address current knowledge on coronaviruses from a short history to epidemiology, pathogenesis, clinical manifestation of the disease, as well as treatment and prevention strategies. 2020-04-02
32236983 As yet, effective treatment is unavailable. […] However, the results of preliminary studies and clinical trials are improving our understanding of the pathogenesis and treatment of Covid-19. 2020-04-02
32237160 Chinese medical staff have summarized a set of effective strategies and methods in the diagnosis and treatment of this disease that are worthy of reference for their international counterparts. 2020-04-10
32237206 Furthermore, the rising prevalence of obesity in the US and prior experience of the impact of obesity on mortality from H1 N1 Influenza should increase the sensitivity of clinicians caring for patients with obesity and COVID-19 to the need for aggressive treatment of such patients. 2020-04-02
32237998 It is unknown if dermatologists are assisting with the public health officials’ recommendations for social distancing by closing their practice or limiting their practice to the treatment of emergency conditions. 2020-04-15
32238232 Thus, treatment approaches should include antiviral and anti-proinflammatory cytokines, anti-infectious and life support therapies, especially in patients with severe diseases. 2020-04-02
32238260 Thus leading to a delay in the diagnosis of COVID-19 infection and further spread of the virus, since in most cases of Dengue there are no warning signs and treatment is ambulatory. 2020-04-08
32238504 Neurologists are used to uncertainty - diagnoses are frequently challenging, too often there are limited treatment options, and unpredictable prognoses are our bread and butter. 2020-04-02
32238613 It is important to recognize the risk factors, categorize severity and provide early treatment. 2020-04-16
32238757 Currently, various diagnostic kits to test for COVID-19 are available and several repurposing therapeutics for COVID-19 have shown to be clinically effective. […] Here, we review the current status of epidemiology, diagnosis, treatment, and vaccine development for COVID-19. 2020-04-10
32239127 Epidemiological, clinical, radiological characteristics, underlying diseases, laboratory tests treatment, complications and outcomes data were collected. […] There was no difference in drug treatment rates between the survival and non-survival groups. […] There were no differences in mortality among those who did or did not receive antimicrobial or glucocorticoid drug treatment. 2020-04-02
32239142 Since the preclinical or clinical information of these identified drugs is already available, they might be ready for being clinically tested in the treatment of COVID-19. 2020-04-02
32239799 Coagulopathy in corona virus infection has been shown to be associated with high mortality with high D-dimers being a particularly important marker for the coagulopathy.1 In the latest paper from the same group, the use of anticoagulant therapy with heparin was shown to decrease mortality as well. 2 This is especially so in patients i) who have met the sepsis induced coagulopathy (SIC) criteria ≥4 (40.0% vs 64.2%, P=0.029) compared to those with SIC score <4 (29.0% vs 22.6%, P=0.419).or ii) with markedly elevated D-dimer (greater than six-fold at the upper limit of normal). 2020-04-02
32240303 Emergent policy changes related to telemedicine and the Emergency Medical Treatment and Labor Act (EMTALA) during the novel coronavirus pandemic (COVID-19) have created opportunities for technology-based clinical evaluation, which serves to conserve personal protective equipment (PPE) and protect emergency providers. 2020-04-02
32240462 Apart from supportive care, no specific treatment has been established for COVID-19. 2020-04-02
32240567 While in our centre we did not change our approach to the treatment of our young cancer patients, we developed a qualitative survey to assess their perception of the risk and level of stress. 2020-04-09
32240670 Close monitoring and timely treatment should be performed for the elderly patients at high risk. 2020-04-14
32240751 Palliative care teams may consider expanding their communication training and skillsets to help families consider caring ways to communicate with their children and grandchildren about the coronavirus. […] Palliative care teams are wise to encourage families to ground their communication with children on key values: honesty and trust, self-compassion, safety, sensitivity, connection, preparedness, community-building, recognition of death as a part of the lifecycle, and legacy. 2020-04-02
32240752 We propose that the palliative care team response will occur in two ways: first, communication and second, symptom management. […] We also propose a framework for proactively mobilizing the palliative care workforce to aggressively address goals of care in all patients, with the aim of reducing the need for rationing of resources. 2020-04-03
32240754 Therefore, palliative care is an important part of the response to this pandemic. […] UW Medicine developed a strategy to implement a palliative care response for a multi-hospital healthcare system that incorporates conventional capacity, contingency capacity, and crisis capacity. […] The strategy was developed by our palliative care programs with input from the healthcare system leadership. […] In this publication, we share our multi-faceted strategy to implement high-quality palliative care in the context of the COVID-19 pandemic that incorporates conventional, contingency, and crisis capacity and focuses on the areas of the hospital caring for the most patients: the emergency department, the intensive care units, and the acute care services. […] Strategy planning for delivery of high-quality palliative care in the context of the COVID-19 pandemic represents an important area of need for our healthcare systems. 2020-04-02
32240756 Within weeks, COVID-19 has transformed our practice of palliative care and clinical medicine as we know it. […] In this article, we share just-in-time tips to support palliative care clinicians and program leaders in providing the best care possible by telemedicine. 2020-04-02
32241056 Finally, some suggestions for thoracic surgery clinical practice in non-epidemic area during and after the epidemic of COVID-19 were provided, to help all the thoracic surgery patients receive active and effective treatment. 2020-04-03
32241244 Since most patients with COVID-19 infection share typical imaging features, radiological examinations have an irreplaceable role in screening, diagnosis and monitoring treatment effects in clinical practice. 2020-04-03
32242347 To allocate medical resources efficiently, Korea implemented a novel institution for the purpose of treating patients with cohort isolation out of hospital, namely the Community Treatment Center (CTC). 2020-04-06
32242348 Six patients (21.4%) required supplemental oxygen therapy, but no one needed mechanical ventilation. 2020-04-06
32242438 Mild cases can be managed at home with self-isolation, symptomatic treatment and follow-up if the disease worsens. 2020-04-08
32242947 We aim to explore reliable evidence for the diagnosis and treatment of the COVID-19 by analyzing all the published studies by Chinese scholars on the clinical and imaging features in novel coronavirus pneumonia caused by SARS-CoV-2. 2020-04-10
32243304 Analyses of early prognosis were based on clinical outcomes and trends in laboratory results during treatment. […] Surgical treatment should be carried out cautiously or nonoperative care should be chosen for patients with fracture in COVID-19-affected areas, especially older individuals with intertrochanteric fractures. 2020-04-03
32243668 Many cancer patients frequently visit the hospital for treatment and disease surveillance. […] They may be immunocompromised due to the underlying malignancy or anticancer therapy and are at higher risk of developing infections. 2020-04-05
32243690 Based on the severity of clinical symptoms, chest computer tomography findings and SARS-Cov-2 RNA test results, we admitted the husband to the respiratory intensive care unit (RICU) and used a treatment consisting of immunosuppressant reduction/cessation and low dose methylprednisolone-based therapy, and his wife to the respiratory isolation ward. 2020-04-03
32243697 Both patients were on immunosuppressant therapy and had stable graft function before COVID-19 infection. 2020-04-03
32243911 COVID-19 is a new infectious disease, for which there is currently no treatment. 2020-04-15
32243945 Although all the four patients (including a pregnant woman) recovered from SARS-CoV-2 infection eventually, randomized trials are needed to eliminate the effect of other treatments and investigate the safety and efficacy of convalescent plasma therapy. 2020-04-03
32244059 Currently, there is no proven effective therapy against the virus, and the impact on other diseases is also uncertain, especially inherited arrhythmia syndrome. 2020-04-16
32245083 The scientific community raced to uncover the origin of the virus, understand the pathogenesis of the disease, develop treatment options, define the risk factors, and work on vaccine development. 2020-04-06
32245264 The COVID-19 coronavirus is currently spreading around the globe with limited treatment options available. […] This article presents the rationale for potentially using old drugs (emetine, other ipecac alkaloids or analogues) that have been used to treat amoebiasis in the treatment of COVID-19. […] This paper also discusses the known side effects of emetine and related compounds, how those side effects can be managed, and the optimal method of administration for the potential treatment of COVID-19. […] Given the serious and immediate threat that the COVID-19 coronavirus poses, our long history with emetine and the likely ability of emetine to reach therapeutic concentrations within the lungs, ipecac, emetine, and other analogues should be considered as potential treatment options, especially if in vitro studies confirm viral sensitivity. 2020-04-06
32245395 In this Commentary, we would like to comment on the article titled “A rapid advice guideline for the diagnosis and treatment of 2019 novel coronavirus (2019-nCoV) infected pneumonia (standard version)” as a featured article in Military Medical Research. 2020-04-10
32245396 On 6 February 2020, our team had published a rapid advice guideline for diagnosis and treatment of 2019 novel coronavirus (2019-nCoV) infection, and this guideline provided our experience and make well reference for fighting against this pandemic worldwide. […] However, the coronavirus disease 2019 (COVID-19) is a new disease, our awareness and knowledge are gradually increasing based on the ongoing research findings and clinical practice experience; hence, the strategies of diagnosis and treatment are also continually updated. […] In this letter, we answered one comment on our guideline and provided the newest diagnostic criteria of “suspected case” and “confirmed case” according to the latest Diagnosis and Treatment Guidelines for COVID-19 (seventh version) that issued by the National Health Committee of the People’s Republic of China. 2020-04-10
32245590 Meanwhile, Traditional Chinese Medicine can provide the more effective and personalized treatment via adjusting the specific medicine for each patient based on the different syndromes. […] In addition, TCM often has different effect on the distinct stages of diseases, contributing to the prevention, treatment and rehabilitation. […] Therefore, it is convinced that Traditional Chinese Medicine is an effective treatment for 2019 novel coronavirus pneumonia. 2020-04-08
32245814 Hospital beds, intensive care units (ICUs), and ventilators are vital for the treatment of patients with severe illness. […] In scenario analyses, we varied the delay from symptom onset to self-isolation, the proportion of symptomatic individuals practicing self-isolation, and the basic reproduction number R0 Without self-isolation, when R0 = 2.5, treatment of critically ill individuals at the outbreak peak would require 3.8 times more ICU beds than exist in the United States. 2020-04-04
32245904 To date, no effective treatment has been identified and management for critically ill patients relies on management in intensive care units. […] Therefore, the risk/benefit ratio of systemic anticancer treatment (SACT) has to be considered. […] For each patient, several factors including age and comorbidities, as well as the number of hospital visits for treatment, can influence this risk. […] We hereby propose a tool to support oncologists and physicians in treatment decision for patients with lung cancer. […] There are several variables to consider, including the extent of the epidemic, the local healthcare structure capacity, the risk of infection to the individual, the status of cancer, patients’ comorbidities, age and details of the treatment. 2020-04-10
32246280 All the 48 public tertiary dental hospitals suspended general non-emergency dental treatment while providing emergency dental services only. 2020-04-04
32246317 Whether patients with elevated D-dimer could benefit from anticoagulant treatment was evaluated. […] Patients with severe pneumonia induced by SARS-CoV2 had higher platelet count than those induced by non-SARS-CoV2, and only the former with markedly elevated D-dimer may benefit from anticoagulant treatment. 2020-04-04
32246787 In this paper we summarize what is known about the stress-sleep link and confinement as well as effective insomnia treatment. […] We suggest adaptions of cognitive behavioral therapy elements that are feasible to implement for those facing changed work schedules and requirements, those with health anxiety and those handling childcare and homeschooling, whilst also recognizing the general limitations imposed on physical exercise and social interaction. 2020-04-04
32246834 No specific antiviral drugs have been approved for the treatment of COVID-2019. 2020-04-04
32246879 Over the past few decades, several blood-borne viruses have targeted hemophilia patients requiring treatment with clotting factors derived from human plasma [1]. 2020-04-04
32247050 Based on recently published literatures, official documents and selected up-to-date preprint studies, we reviewed the virology and origin, epidemiology, clinical manifestations, pathology and treatment of 2019-nCoV infection, in comparison with severe acute respiratory syndrome coronavirus (SARS-CoV) and middle east respiratory syndrome coronavirus (MERS-CoV) infection. 2020-04-07
32247056 Specialist Palliative Care services (SPCS) have a vital role to play in the global COVID-19 pandemic. […] SPCS resource capacity is likely to be overwhelmed, and consideration needs to be given to empowering and supporting high-quality primary palliative care in all care locations. […] Our local SPCS have developed a Palliative Care Pandemic Pack to disseminate succinct and specific information, guidance, and resources designed to enable the rapid up-skilling of non-specialist clinicians needing to provide palliative care. 2020-04-04
32247066 For cervical cancer, radiotherapy and concomitant radiochemotherapy could replace surgery as first-line treatment and the value of lymph node staging should be reviewed on a case-by-case basis. 2020-04-13
32247211 Considering minimal risk upon use, a long experience of use in other diseases, cost-effectiveness and easy availability across India, we propose that both these drugs are worthy of fast track clinical trial for treatment, and may be carefully considered for clinical use as experimental drugs. […] Since HCQ has been approved for treatment of diabetes in India, it should be further researched in diabetes and COVID-19, a subgroup where significant mortality has been shown. 2020-04-10
32247213 Search terms were, COVID-19, treatment of coronavirus, COVID 19 and following terms; chloroquine, hydroxychloroquine, ibuprofen, ACE-inhibitors or angiotensin receptor blockers, cardiovascular disease, diarrhoea, liver, testis and gastrointestinal disease. […] We discuss evidence regarding role of chloroquine and hydroxychloroquine in treatment and prophylaxis, use of inhibitors of the renin angiotensin system, safety of ibuprofen, unusual clinical features like gastrointestinal symptoms and interpretation of tests for cardiac enzymes and biomarkers. 2020-04-16
32247898 This paper will attempt to estimate global infection rates and potential resultant mortality in the absence of effective treatment and/or vaccination. 2020-04-05
32247927 The first medication experience of the recovered patients in the US has led remdesivir to be the “specific drug”. […] China has also taken immediate action to put remdesivir into clinical trials with the purpose of applying it into clinical therapeutics for Corona Virus Disease 2019 (COVID-19). 2020-04-14
32248387 This opinion article discusses the increasing attention paid to the role of activating damage-associated molecular patterns (DAMPs) in initiation of inflammatory diseases and suppressing/inhibiting DAMPs (SAMPs) in resolution of inflammatory diseases and, consequently, to the future roles of these novel biomarkers as therapeutic targets and therapeutics. […] For example, we discuss the need to a priori identify and define a context-dependent “homeostatic DAMP:SAMP ratio” in each case and a “homeostatic window” of DAMP and SAMP concentrations to guarantee a safe treatment modality to patients. […] Finally, a few clinical examples of how DAMPs and SAMPs might be used as therapeutic targets or therapeutics in the future are discussed, including inhibition of DAMPs in hyperinflammatory processes (e.g., systemic inflammatory response syndrome, as currently observed in Covid-19), administration of SAMPs in chronic inflammatory diseases, inhibition of SAMPs in hyperresolving processes (e.g., compensatory anti-inflammatory response syndrome), and administration/induction of DAMPs in vaccination procedures and anti-cancer therapy. 2020-04-05
32248521 We also provide guidance on the medical treatment of pregnant women with COVID-19 infection. 2020-04-05
32248675 Three multidisciplinary intensive care units (ICUs) in Hong Kong. […] Six patients (75%) required mechanical ventilation, six patients (75%) required vasopressors and two (25%) required renal replacement therapy. 2020-04-06
32248966 Given the novel nature of COVID-19, no established treatment beyond supportive care exists currently, but extensive public-health measures to reduce person-to-person transmission of COVID-19 have been implemented globally to curb the spread of disease, reduce the burden on healthcare systems, and protect vulnerable populations, including the elderly and those with underlying medical comorbidities. 2020-04-09
32249063 To meet this challenge, this article discusses advances in the research and development of neutralizing antibodies (nAbs) for the prevention and treatment of infection by SARS-CoV-2 and other human CoVs. 2020-04-09
32249089 Four patients received a reduced dose of maintenance immunosuppressive therapy during hospitalization. […] Although greater patient numbers and long-term follow-up data are needed, our series demonstrates that mild COVID-19 infection in KTx recipients can be managed using symptomatic support therapy combined with adjusted maintenance immunosuppressive therapy. 2020-04-06
32249102 Particularly, the community patient population are at high risk of infection and are facing potential failure of proper medication use during the pandemic. […] Pharmacists shall use various approaches to provide PC services in drug dispensing, consulting and referrals, chronic disease management, safe use of infusions, patient education, home care guidance and psychological support to promote the COVID-19 pandemic control and ensure safe medication use of community patients during the pandemic. […] Community pharmacies shall work as a strong supporter of patient’s medication and protective equipment supply. […] Community pharmacists shall be prepared to provide skilled and effective PC services for community patient population to ensure medication safety and promote the overall COVID-19 pandemic control. 2020-04-09
32249257 With no vaccines or drugs approved for prevention and treatment until now, all efforts at drug design and/or clinical trials of already approved drugs are worthy and creditable. […] Very recently, hydroxychloroquine in combination with azithromycin treatment was reported to be effective for COVID-19. 2020-04-06
32249357 Nonetheless, evidence from previous influenza pandemics suggests the following interventions aimed at improving immune response: (1) lose weight with a mild caloric restriction; (2) include AMPK activators and PPAR gamma activators in the drug treatment for obesity associated with diabetes; and (3) practice mild-to-moderate physical exercise. 2020-04-06
32249943 Antiviral therapy was given to all adult patients but to none of the children. 2020-04-06
32250049 We present the case of a 32-day-old boy infected by COVID-19 that presented with an upper air way infection which resolved spontaneously and did not require any therapy. 2020-04-06
32250170 Plant biotechnology offers potential solutions to this pandemic through the development of low-cost vaccines and antibodies useful for therapy, prophylaxis, and diagnosis. 2020-04-16
32250244 Based on the current clinical evidence treatment with ACE-inhibitors I (ACEis) or angiotensin receptor blockers (ARBs) continues to provide cardiovascular and renal protection in patients diagnosed with COVID-19. 2020-04-15
32250347 In December 2019, in the city of Wuhan, in the Hubei province of China, treatment-resistant cases of pneumonia emerged and spread rapidly for reasons unknown. 2020-04-10
32250385 To characterize patients with coronavirus disease 2019 (COVID-19) requiring treatment in an intensive care unit (ICU) in the Lombardy region of Italy. 2020-04-09
32251003 Lung transplantation (LT) as the sole therapy for end-stage pulmonary fibrosis related to acute respiratory distress syndrome has been considered as the ultimate rescue therapy for these patients. 2020-04-06
32251618 PubMed, Google Scholar and Science Direct databases were searched Results: A total 22 articles were found eligible. 8 discuss about treatment outcomes from their applied drugs during treatment of COVID-19 patients, 4 report laboratory tests, one report animal trial and other 9 articles discuss recommendations and suggestions based on the treatment process and clinical outcomes of other diseases such as malaria, ebola, severe acute respiratory syndrome (SARS) and Middle East respiratory syndrome (MERS). 2020-04-13
32251634 Ribavirin, telbivudine, vitamin B12 and nicotinamide can be combined and used for COVID treatment. […] This initiative relocates already marketed and approved safe drugs for potential use in COVID-treatment. 2020-04-16
32251717 This is distinct from HLH associated with immunodeficiency states termed primary HLH -with radically different therapy strategies in both situations. […] We discuss the potential impact of timing of anti-cytokine therapy on viral clearance and the impact of such therapy on intra-pulmonary macrophage activation and emergent pulmonary vascular disease. 2020-04-10
32251731 Given the global health emergency, drug repositioning is the most reliable option to design an efficient therapy for infected patients without delay. […] Using a combination of structural and molecular modelling approaches, this study showed that chloroquine (CLQ), one of the drugs currently under investigation for SARS-CoV-2 treatment, binds sialic acids and gangliosides with high affinity. 2020-04-14
32251767 Combinational therapy may help to reduce the effective concentration of compounds below the therapeutic plasma concentrations and provide better clinical benefits. 2020-04-16
32251794 To date, no specific treatment has been proven to be effective for SARS-CoV-2 infection. […] Given to the previous experience, extracorporeal membrane oxygenation (ECMO) has been proven to be an effective therapy in the treatment of respiratory failure or acute respiratory distress syndrome (ARDS). […] On the basis of similar principle, ECMO may be also an effective therapy in the treatment of severe COVID-19. 2020-04-06
32251796 One patient was discharged within 14 days after treatment. […] Another patient was discharged 25 days after treatment, and his TR-PCR test was still positive on the 15th day. 2020-04-09
32252338 For treatment of people who become infected with COVID-19, higher vitamin D3 doses might be useful. 2020-04-10
32252979 Due to the current pandemic of respiratory disease known as coronavirus disease 2019 (COVID-19) caused by the SARS-CoV-2 virus, many patients with confirmed or suspected COVID-19 infection will require elective surgery, surgery that cannot be postponed, or emergency surgical treatment. […] This document explains the main principles to consider when managing confirmed or suspected COVID-19 patients during evaluation as well as when surgical treatment is required. 2020-04-10
32253068 The management includes ventilatory support and broad-spectrum antiviral drugs, empirically utilized, as a targeted therapy and vaccines have not been developed. […] Checkpoints inhibitors such as anti-CD200 and anti-PD1 could have a role in the treatment of CoViD-19. […] Rheumatic disease patients taking immunosuppressive drugs should be recommended to maintain the chronic therapy, prevent infection by avoiding social contacts and pausing immunosuppressants in case of infection. 2020-04-15
32253318 This study showed CP therapy was well tolerated and could potentially improve the clinical outcomes through neutralizing viremia in severe COVID-19 cases. […] The optimal dose and time point, as well as the clinical benefit of CP therapy, needs further investigation in larger well-controlled trials. 2020-04-07
32253400 Loquat leaves have long been used as an important material for both pharmaceutical and functional applications in the treatment of lung disease in Asia, especially in China and Japan. […] TF treatment significantly inhibited the level of malondialdehyde (MDA) and increased the activity of superoxide dismutase (SOD). […] It suggested that TF derived from loquat leaves could be considered to be an alternative or a new functional material and used for the treatment of CS-induced COPD. 2020-04-07
32253759 Tocilizumab (TCZ), a monoclonal antibody against interleukin-6 (IL-6), emerged as an alternative treatment for COVID-19 patients with a risk of cytokine storms recently. […] In the present study, we aimed to discuss the treatment response of TCZ therapy in COVID-19 infected patients. […] The demographic, treatment, laboratory parameters of C-reactive protein (CRP) and IL-6 before and after TCZ therapy and clinical outcome in the 15 COVID-19 patients were retrospectively assessed. […] Although TCZ treatment ameliorated the increased CRP in all patients rapidly, for the four critically ill patients who received an only single dose of TCZ, three of them (No. 1, 2, and 3) still dead and the CRP level in the rest one patient (No. 7) failed to return to normal range with a clinical outcome of disease aggravation. […] Serum IL-6 level tended to further spiked firstly and then decreased after TCZ therapy in 10 patients. […] A persistent and dramatic increase of IL-6 was observed in these four patients who failed treatment. […] TCZ appears to be an effective treatment option in COVID-19 patients with a risk of cytokine storms. 2020-04-15
32253799 It is distinguishable by its longer incubation period, more varied morphology with initially urticarial and later targetoid and arcuate plaques, recalcitrance to therapy and longer duration. 2020-04-16
32253888 It is hoped that certain drugs, such as CoV-19 receptor blockers, anti-inflammatories (against rheumatic diseases), monoclonal antibodies, anti-IL-1 and anti-IL-6, the remdesevir drug (analogue adenosine, effective against ebola), hydroxychloroquine (for the treatment of malaria) and vaccines, will open up new strategies and new therapeutic ways to combat this terrible virus. 2020-04-15
32253890 This article analyzes the challenges of medical education in the dilemma of “separation of medical treatment and prevention”, and the new requirements for preventive medical education in the construction of New Medicine under the Healthy China strategy. 2020-04-07
32253891 As a newly epidemic, COVID-19 with a concentrated outbreak poses a great challenge to medical treatment. […] The surgeon participated in emergency medical rescue could provide professional treatment for the patients combined with surgical diseases, specialized training for the non-surgeon crew, to reduce surgical-related mortality. 2020-04-07
32254064 To date, there are no proven options for prophylaxis for those who have been exposed to SARS-CoV-2, nor therapy for those who develop COVID-19. […] There are numerous examples, where convalescent plasma has been used successfully as post-exposure prophylaxis and/or treatment of infectious diseases, including other outbreaks of coronaviruses (e.g., SARS-1, Middle East Respiratory Syndrome [MERS]). […] Data from rigorously controlled clinical trials of convalescent plasma are also few, underscoring the need to evaluate its use objectively for a range of indications (e.g., prevention vs treatment) and patient populations (e.g., age, comorbid disease). 2020-04-07
32255382 Demographic, clinical, laboratory, and treatment data were collected and analyzed, and final date of follow-up was February 24, 2020. 2020-04-07
32255489 Hydroxychloroquine (HCQ) appears to be a promising treatment for COVID-19. 2020-04-07
32255510 In patients with suspected or confirmed COVID-19 disease, all immunomodulators used for skin diseases should be immediately withheld, with the possible exception of systemic corticosteroid therapy, which needs to be weaned. 2020-04-07
32256547 More than 80 clinical trials have been launched to test coronavirus treatment, including some drug repurposing or repositioning for COVID-19. 2020-04-09
32256705 No conclusive evidence for or against the use of non-steroidal anti-inflammatory drugs (NSAIDs) in the treatment of COVID-19 patients is available, nor is there evidence indicating that TNFα blockade is harmful to patients in the context of COVID-19. […] Although there are potential targets in the JAK-STAT pathway that can be manipulated in treatment for coronaviruses and it is evident that IL-1 is elevated in patients with a coronavirus, there is currently no evidence for a role of these drugs in treatment of COVID-19. […] The COVID-19 pandemic has led to challenging decision-making about treatment of critically unwell patients. 2020-04-09
32257537 Among them, two common and one severe patient were recovered and discharged in 10 days after treatment. […] After treatment, the peripheral lymphocytes were increased, the C-reactive protein decreased, and the overactivated cytokine-secreting immune cells CXCR3+CD4+ T cells, CXCR3+CD8+ T cells, and CXCR3+ NK cells disappeared in 3-6 days. […] Meanwhile, the level of TNF-α was significantly decreased, while IL-10 increased in MSC treatment group compared to the placebo control group. […] Thus, the intravenous transplantation of MSCs was safe and effective for treatment in patients with COVID-19 pneumonia, especially for the patients in critically severe condition. 2020-04-09
32257554 Therefore, MSC therapy inhibiting the overactivation of the immune system and promoting endogenous repair by improving the lung microenvironment after the SARS-CoV-2 infection found in this study is striking. 2020-04-09
32258207 Until now, no definite effective treatment has been identified. 2020-04-09
32258351 In particular, the current coronavirus disease 2019 (COVID-19) pandemic has quickly intensified interest in developing treatment options to mitigate impact on human life. […] Remdesivir (GS-5734™) is a broad-spectrum antiviral drug that is now being tested as a potential treatment for COVID-19 in international, multi-site clinical trials. 2020-04-07
32259123 Where needed, clients are referred to 16-hour treatment clinics, which are specifically set up for the diagnosis and treatment of the disease, to the hospitals, or will be treated at home. 2020-04-09
32259129 Therefore, studies with a large sample size are required to determine the efficacy of metronidazole in the treatment of COVID-19 infection. 2020-04-09
32259247 Access to pain treatment has been called a fundamental human right by numerous organizations. 2020-04-07
32259313 As the incidence continues to rise at a rapid pace, critical care teams are faced with challenging treatment decisions. […] Urgent identification of potential treatment strategies is a priority. 2020-04-07
32259477 Thus, ferrets represent an infection and transmission animal model of COVID-19 that may facilitate development of SARS-CoV-2 therapeutics and vaccines. 2020-04-10
32259899 The only method to understand the clustering and the immediate hospital resource needs is mandatory, uniform, daily reporting of hospital censuses of COVID-19 cases admitted to hospital wards and intensive care units. 2020-04-10
32264666 Although several comorbidities such as hypertension, diabetes and cardiovascular diseases are defined as a risk factor for developing the acute respiratory syndrome and need for intensive care; immune-compromised situations such as rheumatic disease which require immunosuppressive treatment strikingly are not found to be a risk factor for more severe disease course. 2020-04-08
32265310 Limited pre-clinical data suggest that systemic MSC administration can significantly reduce respiratory virus (Influenza strains H5N1 and H9N2)-induced lung injury, however, there are no available data in models of coronavirus respiratory infection.There are a rapidly increasing number of clinical investigations of cell-based therapy approaches for COVID-19. 2020-04-10
32265848 This review was written for the topic of Antivirals for Emerging Viruses: Vaccines and Therapeutics in the Virology section of Frontiers in Microbiology. 2020-04-10
32266381 We describe correlations between laboratory parameters and treatment duration (r= -0.637; p=0.002) and time to virus recrudescence (r= 0.52; p=0.008) respectively, suggesting the need for additional measures to confirm illness resolution in COVID-19 patients. 2020-04-08
32266708 Cardiovascular diseases, in particular hypertension, as well as the cardiovascular treatment with Renin-Angiotensin System inhibitors such as Angiotensin Converting Enzyme (ACE) inhibitors and Angiotensin Receptor Blockers (ARBs), are claimed once again as mechanisms of Severe Acute Respiratory Syndrome (SARS) during the COVID-19 outbreak due to Cov-2 epidemics. 2020-04-16
32266987 To assess the efficacy of corticosteroid treatment of patients with coronavirus disease 2019 (COVID-19). […] Virus clearance time, length of hospital stay, and duration of symptoms, by treatment type (including or not including corticosteroid therapy). […] Eleven of 31 patients with COVID-19 received corticosteroid treatment. […] Cox proportional hazards regression analysis indicated no association between corticosteroid treatment and virus clearance time (hazard ratio [HR], 1.26; 95% CI, 0.58-2.74), hospital length of stay (HR, 0.77; 95% CI, 0.33-1.78), or duration of symptoms (HR, 0.86; 95% CI, 0.40-1.83). […] Corticosteroids are widely used when treating patients with COVID-19, but we found no association between therapy and outcomes in patients without acute respiratory distress syndrome. 2020-04-08
32266994 In addition, we would like to mention that amiloride, which increases the cytosolic pH, can be used in the COVID-19 treatment. 2020-04-08
32267072 Anakinra, a recombinant IL-1 receptor antagonist, has been used subcutaneously and intravenously in pediatric patients and is considered a first-line treatment for MAS and secondary HLH (sHLH) among many pediatric rheumatologists. […] Previous reports of anakinra used in adults for treatment of MAS or sHLH are limited to subcutaneous administration. 2020-04-09
32267109 In the absence of specific anti-viral molecules, treatment is currently mainly symptomatic. 2020-04-09
32267139 This axis might be a potential target for the treatment of brain metastasis of lung cancer. 2020-04-09
32267556 A number of novel and repurposed therapies agents with activity against SARS-CoV-2 have been identified and most institutions have developed clinical pathways to operationalize their use in appropriate COVID-19 patients.1-3 However, optimal drug therapy decisions for those with moderate to severe COVID-19 infections are extremely challenging at this time as evidence is limited. 2020-04-08
32267560 The main mechanism of ARDS is uncontrolled systemic inflammatory response and cytokine storm following release of proinflammatory cytokines (such as interferons (IFN), interleukines (IL), tumor necrosis factor (TNF)-α) and chemokines.2-3 So, some Chinese researchers proposed or used anti-inflammatory agents in the treatment regimen of patients with COVID-19.3-4. 2020-04-08
32267566 Based on the available evidence we believe that tetracyclines may be effective agents in the treatment of COVID-19. 2020-04-08
32267771 Here, we present the rationale and design of a large, international trial that combines features of adaptive platform trials with pragmatic point-of-care trials to determine best treatment strategies for patients admitted to an intensive care unit with severe community-acquired pneumonia (CAP). […] The trial randomizes patients to multiple interventions within 4 treatment domains: antibiotics, antiviral therapy for influenza, host immunomodulation with extended macrolide therapy, and alternative corticosteroid regimens, representing 240 treatment regimens. 2020-04-09
32267987 At present, there is no specific antiviral therapy for COVID-19 and the main treatments are supportive. 2020-04-08
32267998 There is evidence in both animals and humans that fibrinolytic therapy in Acute Lung Injury and ARDS improves survival, which also points to fibrin deposition in the pulmonary microvasculature as a contributory cause of ARDS and would be expected to be seen in patients with ARDS and concomitant diagnoses of DIC on their laboratory values such as what is observed in more than 70% of those who die of COVID-19 (8-10). 2020-04-08
32268005 Therapeutics are desperately needed to reduce the morbidity and mortality of this pandemic disease. […] It has been reported that hydroxychloroquine (HCQ) is active against SARS-CoV-2 in vitro, and this finding was quickly supported by an open label non-randomized clinical trial that provided the first published clinical evidence HCQ may be a treatment option. 2020-04-11
32268018 To analysis the medication characteristics of the prescriptions issued via open channel by the National and Provincial Health Committee and the State Administration of Traditional Chinese Medicine in treating coronavirus disease 2019 (COVID-19). […] We collected the data of traditional Chinese medicine related to treatment plans published by the National and Provincial Health Committee and the State Administration of Traditional Chinese Medicine from the start of COVID-19 outbreak in Wuhan to February 19, 2020. […] The study collected 4 national and 34 regional prevention and treatment plans, 578 items, 84 traditional Chinese formulations, 60 Chinese patent medicines, and 230 Chinese herbs. […] The main medication characteristics are clearing heat, entilating lung, removing toxicity and removing turbidity. 2020-04-10
32268019 We applied HFNC for oxygen therapy in severe and critical COVID-19 patients and summarized the following experiences. […] Thirdly, to avoid hypoxia or hypoxemia, the treatment goal of HFNC should be maintained the oxygen saturation (SpO2) above 95% for patients without chronic pulmonary disease. […] Finally, patients should wear a surgical mask during HFNC treatment to reduce the risk of virus transmission through droplets or aerosols. 2020-04-10
32268454 Objective: To introduce Treatment experience of burn patients combined with inhalation injury during epidemic period of Corona Virus Disease 2019 (COVID-19). Methods: Six burn patients combined with inhalation injury were hospitalized in Department of Burns of Tongren Hospital of Wuhan University& Wuhan Third Hospital from February 1 to March 1 in 2020duringhigh-incidence period of COVID-19, including 4 males and 2 females, aged 21-63 years, hospitalized for 2-4 hours, with total burn areas of 1%-20% TBSA and full-thickness burn areas of 1%-12% TBSA. […] After admission, 6 patients were given routine treatment, the medical staffs paid attention to the protection and screened COVID-19 according to the diagnosis and treatment plan of COVID-19. […] After treatment for 14-32 days, 6 patients were cured and discharged. Conclusions: During the novel coronavirus, burn patients combined with inhalation injury should be treated under condition of good protection for COVID-19 among doctors and nurses. 2020-04-08
32268515 Finally, we focused on the genes in the network that are already associated with known drugs and evaluated their role for a potential treatment of Covid-19. […] Among possible interesting drugs for Covid-19 treatment, we found Nimesulide, Fluticasone Propionate, Thiabendazole, Photofrin, Didanosine and Flutamide. 2020-04-13
32268641 This guideline is applicable to the health protection requirements of large indoor stadiums which are reconstructed as treatment sites for COVID-19 patients with mild symptoms during the outbreak. 2020-04-10
32268719 Severe COVID-19 illness is characterised by the development of Acute Respiratory Distress Syndrome (ARDS), for which the mainstay of treatment is represented by mechanical ventilation. 2020-04-10
32268923 The virus first appeared in Wuhan, China, in late December 2019, and traditional Chinese herbal medicine is being used for its treatment. […] The use of traditional Chinese herbal medicine for treatment or prevention of these novel viral infections affecting the pneumonia will be investigated. 2020-04-14
32269087 Supportive treatment was provided for all 4 newborn babies. 2020-04-11
32269597 He was undergoing chemotherapy and had just returned to Nigeria following medical treatment in the United Kingdom. 2020-04-11
32269598 This is of particular interest in oncology since patients receiving some cancer treatments such as chemotherapy or immune therapy often experience similar symptoms as side-effects. […] Whilst more data is currently needed to strengthen our knowledge of the symptoms of COVID-19, oncology patients who are concerned about anosmia or ageusia in the context of their systemic anti-cancer therapy should contact their acute oncology support line for advice. 2020-04-09
32269893 The penultimate portion of the review aims to explain the involvement of micronutrients such as vitamin C and vitamin D in COVID19 treatment and prophylaxis. 2020-04-11
32270359 We would like to share our experience and send a clear message to keep a high attention on stroke as an emergency condition, because we have observed a decreased number of patients with minor strokes and TIAs, longer onset-to-door and door-to-treatment times for major strokes, and a reduced number of transfers from spokes. 2020-04-11
32270371 To date, there is no specific therapy for COVID-19. 2020-04-09
32270515 He received antiviral treatment plus recombinant human Erythropoietin(rhEPO) due to his severe anemia. […] After 7 days of treatment, he was discharged with miraculous improvement in his symptoms and hemoglobin level. 2020-04-09
32270592 Five (50.0%) patients received antiviral treatment. 2020-04-09
32271376 When comparing patients with early (<15 days) and late viral RNA clearance (≥15 days after illness onset), prolonged SARS-CoV-2 RNA shedding was associated with male sex (p=0.009), old age (p=0.033), concomitated with hypertension (p=0.009), delayed admission to hospital after illness onset (p=0.001), severe illness at admission (p=0.049), invasive mechanical ventilation (p=0.006), and corticosteroid treatment (p=0.025). 2020-04-09
32271454 Employing combined therapy of modern medicine and traditional Chinese medicine has been proposed, in which Ma Xing Shi Gan Decoction (MXSGD) was recommended as a basic prescription and applied widely in the clinical treatment of COVID-19. 2020-04-15
32271455 The treatment of severe COVID-19 patients has been rarely reported. 2020-04-15
32271456 Both groups achieved good therapeutic effect with the body temperature of patients decreased gradually from admission to the 10th day of treatment. […] The number of days for nCoV-RNA turning negative after treatment was significantly decreased in the test group than that in the control group. […] Compared with the treatment of pneumonia-associated adjuvant drugs alone, the combination treatment with LPV/r and adjuvant drugs has a more evident therapeutic effect in lowering the body temperature and restoring normal physiological mechanisms with no evident toxic and side effects. […] In view of these conclusions, we suggested that the use of LPV/r combined with pneumonia-associated adjuvant drugs in the clinical treatment for patients with COVID-19 should be promoted. 2020-04-15
32271458 The status of the infected cases can be determined basing on the treatment process along with several other factors. 2020-04-15
32271459 A retrospective analysis was performed on the confirmed cases of COVID-19, who were admitted to the North Hospital of Changsha first Hospital (Changsha Public Health treatment Center) from January 17 to February 7, 2020. 2020-04-15
32271490 Practical suggestions regarding evaluation and treatment will be provided, realizing that there may be constraints on medical resources and the nature of this pandemic remains dynamic. 2020-04-09
32271599 One of the groups that is considered high risk in this pandemic are cancer patients as they are treated with a variety of immune system suppressor treatment modalities and this puts them in a great risk for infectious disease (including COVID-19). […] This article provides the recommendations and possible actions that should be considered by patients, their caregivers and families, physician, nurses, managers and staff of medical centers involved in cancer diagnosis and treatment. […] We pursued two major goals in our recommendations: first, limiting the exposure of cancer patients to medical environments and second, modifying the treatment modalities in a manner that reduces the probability of myelosuppression such as delaying elective diagnostic and therapeutic services, shortening the treatment course, or prolonging the interval between treatment courses. 2020-04-14
32271601 Since there is no specific drug for COVID-19, the treatment is mainly symptomatic supportive therapy. […] In addition, it should be pointed out that patients with severe illness need more aggressive treatment and meticulous care. 2020-04-14
32272173 The conserved nature of the fusion domain and mechanism across the CoV family make it a valuable target to elucidate and develop pan-CoV therapeutics. 2020-04-09
32272396 Since the outbreak of COVID-19, international attention has raised to develop treatment and control options such as types of immunotherapies. 2020-04-15
32272481 Currently there are no targeted therapeutics and effective treatment options remain very limited. 2020-04-09
32272630 His condition deteriorated initially, but eventually improved with supportive treatment and the compassionate use of antivirals and antimalarials and is now in a stable condition. 2020-04-10
32272857 Impact statement Given the steep mortality caused by the recent novel coronavirus (COVID-19) pandemic, there is clear need for advances in diagnostics and therapeutics for viral outbreaks. 2020-04-15
32273253 Hospital pharmacists shall support pharmaceutical care services by participating in making evidence-based decisions for medication, monitoring and evaluation of medication safety and efficacy, providing strengthened care for special population and patients with combined underlying diseases, monitoring and management of convalescent plasma therapy, providing emotional counselling and psychological support, and providing scientific information about COVID-19 vaccines. 2020-04-13
32273489 Computed tomography (CT) manifestations and treatment of children with COVID-19 are still unclear. 2020-04-10
32273490 This review additionally considers COVID-19 in immunosuppressed children, and also suggests a management algorithm for the few children who appear to present with life threatening infection, including the potential use of antiviral and immunomodulatory treatment. 2020-04-10
32274341 In this review, we highlight these important issues based on the recent developments in the field, for optimizing the management and treatment of liver injury in Chinese patients with COVID-19. 2020-04-13
32274342 Based on the current evidence from case reports and case series, this review article focuses on the demographic and clinical characteristics, potential mechanisms, and treatment options for COVID-19-related liver dysfunction. 2020-04-13
32274630 Here, we provide a framework for institutions and governments to help adjudicate treatment allocations to patients with neuro-oncologic disease. 2020-04-13
32274772 Corticosteroid use is a mainstay of therapy for those women delivering prematurely. […] · Corticosteroid use is an important part of prematurity treatment because it provides benefit to the fetus.. 2020-04-10
32274773 In about 20% of patients, severe symptoms occur after a mean incubation period of 5 - 6 days; 5% of patients need intensive care therapy. […] Therapy is based on established recommendations issued for patients with acute lung injury (ARDS). […] Lung protective ventilation, prone position, restrictive fluid management and an adequate management of organ failures are the mainstays of therapy. 2020-04-13
32274774 The general treatment principles in dealing with COVID-19 patients and the recommendations for action in intensive care therapy also apply to pregnant and postpartum patients. 2020-04-13
32275128 To analyze the roles of multidisciplinary team (MDT) in the diagnosis and treatment of suspected cases of corona virus disease 2019 (COVID-19). […] With the guidance of MDT, one COVID-19 patient was transferred to designated provincial hospital after effective treatment; one patient complicated with acute cholecystitis underwent gallbladder puncture and drainage; and COVID-19 was excluded in a highly suspected patient after alveolar lavage fluid examination. […] The efficiency of diagnosis and treatment for suspected COVID-19 patients can be improved under MDT mode, particularly for complicated and refractory cases. 2020-04-13
32275256 However, no specific drug has been previously approved for the COVID-19 treatment. […] The Lombardy Section of the Italian Society of Infectious and Tropical Diseases provided this «vademecum» with the aim to explore the current evidence about the drugs likely to be efficacious in the treatment of COVID-19. […] Lastly, a collaborating group with immunologists and rheumatologists has been built with the aim of providing some guidance about the use of tocilizumab, a promising option for the treatment of the hyperinflammatory state occurring in most patients affected by COVID-19. 2020-04-15
32275257 Radiological and serological methods are the most preferred among the other methods and the radiological method is the most preferred one which can diagnose the infection quickly and accurately with fewer false-negatives, that can be effective in protecting the patient’s life by initiating treatment and preventing the transmission of infection to other people. 2020-04-15
32275295 Rates of laboratory-confirmed COVID-19 infections (defined as the number of cases per day per million people), across age, sex, and geographic locations were calculated across 5 periods: December 8 to January 9 (no intervention), January 10 to 22 (massive human movement due to the Chinese New Year holiday), January 23 to February 1 (cordons sanitaire, traffic restriction and home quarantine), February 2 to 16 (centralized quarantine and treatment), and February 17 to March 8 (universal symptom survey). 2020-04-14
32275452 We compared the clinical characteristics, laboratory examinations, CT images and treatment of COVID-19 patients from three different cities in China. 476 patients were recruited from Jan 1 to Feb 15, 2020 at three hospitals in Wuhan, Shanghai and Anhui. […] Patients were divided into four groups according to age and into three groups (moderate, severe, and critical group) according to the fifth version of the guidelines issued by the National Health Commission of China on Diagnosis and Treatment of COVID-19. 2020-04-10
32275463 Anesthesiology specialists and residents who perform emergency operations on these patients in settings other than intensive care units should follow simple and easy-to-understand algorithms to ensure safety. 2020-04-10
32275497 Contamination was greater in intensive care units than general wards. 2020-04-10
32275740 The ILROG guidelines for using radiation therapy in hematological malignancies are widely used in many countries. […] The emergency situation created by the COVID-19 pandemic may result in limitations of treatment resources. […] Furthermore, in recognition of the need to also reduce the exposure of patients and staff to potential infection with COVID-19, the ILROG task force has made recommendations for alternative radiation treatment schemes. 2020-04-10
32275753 Levels of their lung lesions, oxygen saturation and heart rates were compared before and after treatment by CT scanning images and patient monitor. 2020-04-10
32275775 Entire hospitals have been converted into intensive care units, retired anesthesiologists have been called back to work, and specialists in other branches have been assigned to assist COVID-19 patients. 2020-04-10
32275784 Telemedicine, defined as the delivery of health care services at a distance using electronic means for diagnosis and treatment, holds tremendous promise to increase access to broadly specialty care. 2020-04-10
32275805 The study exposes the tension between a healthcare worker’s right to protection and a duty to provide treatment. 2020-04-10
32275812 Patients received a 10-day course of remdesivir, consisting of 200 mg administered intravenously on day 1, followed by 100 mg daily for the remaining 9 days of treatment. […] Of the 61 patients who received at least one dose of remdesivir, data from 8 could not be analyzed (including 7 patients with no post-treatment data and 1 with a dosing error). […] Measurement of efficacy will require ongoing randomized, placebo-controlled trials of remdesivir therapy. 2020-04-10
32275914 In this review, we discuss preliminary data concerning the potential activity of type 1 interferons on SARS-CoV-2, and the relevance of evaluating these molecules in clinical trials for the treatment of COVID-19. 2020-04-16
32276097 Ageing adults (65+) with disability are especially vulnerable to COVID-19 and upon contracting, are a cohort most likely to require palliative care. […] Therefore, it is very important that health services - particularly health services providing palliative care - are proximately available. […] The geographic dispersion of areas with people vulnerable to COVID-19 with poor access to palliative care and health services are clarified. […] The spatial methodology employed can be implemented in different contexts to support evidence-based COVID-19 and pandemic palliative care service decisions. 2020-04-13
32276099 Palliative care teams who practice in the community setting are faced with a difficult task: How do we actively triage the most urgent visits while keeping our vulnerable patients safe from the pandemic? […] The following are recommendations created by the Palo Alto Medical Foundation Palliative Care and Support Services team to help triage and coordinate for timely, safe, and effective palliative care in the community and outpatient setting during the ongoing COVID-19 pandemic. […] We recommend active triaging, communication, frequent screening for COVID-19 symptoms for palliative care patients been evaluated in the community setting. […] An understanding of infection risk, mutual consent between designated providers, patients, and their families are crucial to maintaining safety while delivering community-based palliative care during the COVID-19 pandemic. 2020-04-12
32276102 While palliative care specialists have training in these skills, many front-line clinicians from other specialties do not. 2020-04-13
32276137 While specific treatment is not yet coming soon, individual risk assessment and management strategies are crucial. 2020-04-13
32276140 In this report we suggest that patients with systemic lupus erythematous might be especially prone to severe COVID-19 independent of their immunosuppressed state from lupus treatment. […] Epigenetic control of the ACE2 gene might be a target for prevention and therapy in COVID-19. 2020-04-13
32276848 Epidemiological, clinical, laboratory, and radiological characteristics and treatment data were collected. 2020-04-14
32276929 The modulation of its expression by sex steroids could contribute to the male predominance of severe infections and given that TMPRSS2 has no known indispensable functions, and inhibitors are available, it is an appealing target for prevention or treatment of respiratory viral infections. 2020-04-11
32276930 Amid concerns over the spread of COVID-19, oncology practices have “gone virtual,” with video appointments scheduled for any service that does not require diagnostic testing or treatment. 2020-04-11
32277040 The structure provides a basis for the design of new antiviral therapeutics targeting viral RdRp. 2020-04-11
32277065 The nucleotide analogue remdesivir is an investigational drug for the treatment of human coronavirus infection. 2020-04-13
32277351 The outbreak of COVID-19 affects the management of these chronic conditions, not only for those who are already receiving treatment but also for those who are about to start a new treatment to control their disease. 2020-04-11
32277367 Current international society recommendations suggest that patients with rheumatic diseases on immunosuppressive therapy should not stop glucocorticoids during COVID-19 infection, although minimum possible doses may be used. 2020-04-11
32277387 It is urgent to set up guidelines for the prevention, diagnosis, and treatment of COVID-19 in liver transplant recipients. 2020-04-11
32277408 After receiving antiviral therapy and mechanical life support, Trop I was reduced to 0.10 g/L, and interleukin-6 was reduced to 7.63 pg/mL. 2020-04-11
32277490 This means that, also during this pandemic, fetal anomalies will be detected, and that discussions regarding invasive genetic testing and possibly fetal therapy will need to take place. 2020-04-11
32277555 This case states the importance of close monitoring of the concentration of ciclosporin in patients treated with lopinavir/ritonavir, routine treatment of corticosteroid can be continued. […] Further data are needed to achieve better understanding of the impact of immunosuppressive therapy on the clinical presentation, severity and outcome of SARS-CoV-2 infections in solid organ transplant recipients. 2020-04-11
32277967 Monitoring dynamic changes of SAA, combined with CT imaging could be valuable in diagnosis and treatment of COVID-19. 2020-04-14
32278065 Current treatment is supportive, but several options appear promising and are the subject of investigation. 2020-04-13
32278097 This study aimed to synthesise evidence for the role and response of palliative care and hospice teams to viral epi/pandemics, to inform the COVID-19 pandemic response. 2020-04-13
32278175 Hence, the recent outburst of COVID-19 highlights an urgent need for therapeutics targeting SARS-CoV-2. […] Further, the current treatment options, drugs available, ongoing trials and recent diagnostics for COVID-19 have been discussed. 2020-04-16
32278693 Precautionary measures remain the sole obliging tactic to cease the person to person transmissions till any effective method of treatment or vaccine is developed. […] Along with these, Methisazone an inhibitor of protein synthesis, CGP42112A an angiotensin AT2 receptor agonist and ABT450 an inhibitor of the non-structural protein 3-4A might become convenient treatment option as well against COVID-19. […] The drug repurposing approach provide an insight about the therapeutics that might be helpful in treating corona virus disease. 2020-04-12
32278716 The aim of these “crisis-driven” recommendations is (1) to ensure appropriate and timely treatment of SHD patients, (2) to minimize the risk of COVID-19 exposure to patients and healthcare workers, and (3) to limit resource utilization under conditions of constraint. 2020-04-12
32278725 Surgical treatment of non-COVID-19 related disease during this period, however, still remains necessary. 2020-04-16
32278764 We searched for articles in PubMed and Google Scholar databases till 02 April 2020, with the following keywords: “SARS-CoV-2”, “COVID-19”, “infection”, “pathogenesis”, “incubation period”, “transmission”, “clinical features”, “diagnosis”, “treatment”, “diabetes”, with interposition of the Boolean operator “AND”. 2020-04-16
32278766 Clinical pharmacists’ routine task is carrying out pharmaceutical care to ensure patients’ safe and reasonable medication use. […] Facing public health emergencies, clinical pharmacists can give full play to their professional expertise, analyze the current situation rationally, formulate telehealth strategies swiftly, and work in a united and efficient manner to provide innovative pharmacy services to ensure medication safety and rational use of medicine. 2020-04-12
32278811 Given the extreme importance of the current pandemic caused by COVID-19, and due to the fact that scientists agree that there is no identified pharmacological treatment where possible therapeutic alternatives are raised through drug repositioning. […] We present a selection of studies involving drugs from different pharmaceutical classes with activity against SARS-CoV-2 and SARS-Cov, with potential use in the treatment of COVID-19 disease. 2020-04-12
32278865 Since the beginning of COVID-19 epidemic, we shifted all PAD patients to home therapy, and activated remote visits. […] Health-Related-Quality of Life was similar in patients forced to shift from hospital-based to home-based immunoglobulin treatment and in patients who continued their usual home-based replacement. 2020-04-12
32278932 The emergence of the COVID-19 pandemic has severely affected medical treatment protocols throughout the world. 2020-04-12
32279346 In patients with COIVD-19, in the early aggravation phase before treatment, observation of peripheral blood film shows the presence of pronounced morhological anomalies of the granulocyte series. […] One week after the start of treatment, such anomalies subside, and an increasing proportion of reactive lymphocytes dominates. 2020-04-12
32279418 During the novel coronavirus pandemic, organ transplant recipients represent a frail susceptible category due to long-term immunosuppressive therapy. […] For this reason, clinical manifestations may differ from general population and different treatment approaches may be needed. […] The patient was left with steroid therapy alone. […] We stress the need for guidelines in transplant recipients with COVID-19 infection with particular regard to the management of therapy. 2020-04-12
32279469 There is currently no robust evidence to support prescribing hydroxychloroquine as a treatment or prophylaxis for COVID-19. 2020-04-13
32280433 Due to the lack of effective treatment options for SARS-CoV-2, various strategies are being tested in China, including drug repurposing. […] The result showed that atazanavir, an antiretroviral medication used to treat and prevent the human immunodeficiency virus (HIV), is the best chemical compound, showing an inhibitory potency with Kd of 94.94 nM against the SARS-CoV-2 3C-like proteinase, followed by remdesivir (113.13 nM), efavirenz (199.17 nM), ritonavir (204.05 nM), and dolutegravir (336.91 nM). […] In addition, we also found that several antiviral agents, such as Kaletra (lopinavir/ritonavir), could be used for the treatment of SARS-CoV-2. […] Overall, we suggest that the list of antiviral drugs identified by the MT-DTI model should be considered, when establishing effective treatment strategies for SARS-CoV-2. 2020-04-16
32281052 However, no standard treatment for this disease has been discovered to date. […] Probably, preventing the severe acute respiratory infection form of COVID-19 as the most dangerous phase of this disease can be helpful for the treatment and reduction of the death rate. […] In this regard, mesenchymal stem cells (MSCs)-based immunomodulation treatment has been proposed as a suitable therapeutic approach and several clinical trials have begun. […] Given the uncertainties in this area, we reviewed reported clinical trials and hypotheses to provide useful information to researchers and those interested in stem cell therapy. […] In this study, we considered this new approach to improve patient’s immunological responses to COVID-19 using MSCs and discussed the aspects of this proposed treatment. […] However, currently, there are no approved MSC-based approaches for the prevention and/or treatment of COVID-19 patients but clinical trials ongoing. 2020-04-13
32281114 A case of late initiation of remdesivir antiviral therapy in the successful treatment of a patient with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in a mixed medical ICU of a community teaching hospital is presented. 2020-04-13
32281214 Aside from the pulmonary manifestations of disease, there are likely to be several electrophysiologic (EP) sequelae of COVID-19 infection and its treatment, due to consequences of myocarditis and the use of QT-prolonging drugs. 2020-04-13
32281317 Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus-2 not yet has established its treatment, but convalescent plasma has been expected to increase survival rates as in the case with other emerging viral infections. […] To our knowledge, this is the first report of the use of convalescent plasma therapy for COVID-19 in Korea. 2020-04-15
32281327 Currently, there is no specific drug or vaccine besides symptomatic supportive therapy. […] In view of the high homology between the gene sequences of the novel coronavirus and SARS virus, and the similarities between the two in terms of pathogenic mechanism and clinical manifestations, our team established a rapid screening and optimization model for the prevention and treatment of the novel coronavirus based on clinical experience and molecular docking technology. […] This provides evidence for the scientific and potential efficacy of the TCM prescription from the perspective of treatment target analysis, and also suggests that the TCM prescription has the potential to directly inhibit viral infection in addition to improving clinical symptoms or syndromes. […] Based on this, our team optimized and formed a new anti-coronavirus TCM prescription &quot;Keguan Yihao&quot;, immediately providing the TCM prescription with certain clinical experience and objective evidence support for the prevention and treatment of new emergent infectious diseases in our hospital. […] The TCM prescription was combined with modern medicine symptomatic supportive treatment for clinical treatment, preliminary results showed better effect than symptomatic supportive therapy alone. 2020-04-14
32281328 This study established optimization docking models and virtual screening to discovery potential active herbs for the prevention and treatment of the novel coronavirus based on molecular docking technology. […] By combining the diagnosis and treatment scheme of Hunan province’s and angiotensin converting enzyme 2(ACE2) inhibitors screening from literature, present study also discussed the rational application of candidate herbs to this epidemic situation. 2020-04-14
32281329 In the end, we obtained the potential active prescriptions on &quot;cytokine storm&quot; according to the potential herbs in the &quot;National novel coronavirus pneumonia diagnosis and treatment plan(trial version sixth)&quot;. 2020-04-14
32281330 To analyze the registered clinical trial protocols of traditional Chinese medicine(TCM) for the prevention and treatment of coronavirus disease 2019(COVID-19), in order to provide information for improving the quality of research design. […] There was a quick response of clinical research on the prevention and treatment of COVID-19 with TCM, with the current registered protocols covers the whole process of disease prevention, treatment and rehabilitation. 2020-04-14
32281331 To investigate the regularity of prescription and clinical syndromes by analyzing the diagnosis and treatment protocols of traditional Chinese medicine(TCM) for coronavirus disease 2019(COVID-19), so as to provide references for syndrome differentiation and relevant researches. […] The diagnosis and treatment protocols of COVID-19 published by national and regional health authorities were searched, and information was extracted in regard to disease stages, type of syndromes, and prescriptions, etc. […] A total of 26 diagnosis and treatment protocols of TCM for COVID-19 were retrieved after screening(including 1 national scheme and 25 regional ones), among which 16 contained aspects of both prevention and treatment, 7 only involved treatment contents and 3 were prevention schemes. […] There were many diagnosis and treatment protocols for COVID-19 have been published, which generally followed the national edition, through with certain personalities in different regional protocols. […] There were common features with respect to the disease stage, syndrome differentiation, therapeutic principles and methods, as well as prescriptions; the treatment were generally carried out against the core pathogenesis and progress of the disease. […] Along with the deepening recognition of COVID-19, the diagnosis and treatment protocols are still need further concretization and standardization. […] We hope researchers and decision-makers can pay more attention to the treatment of Huayu Tongluo in severe and recovery period. 2020-04-14
32281332 From the medicinal properties to high-frequency drugs and new prescriptions, it could be seen that the overall treatment of COVID-19 by traditional Chinese medicine was to strengthen body resistance, eliminate pathogenic factors, and give attention to Qi and Yin. 2020-04-14
32281333 This study collected prevention and treatment approaches of traditional Chinese medicine for COVID-19 released from the National Health Committee of China, 7 provinces and municipal health committees, the Chinese Medicine Administration and Handbook of Traditional Chinese Medicine Diagnosis and Treatment of COVID-19 between January 1 and February 18, 2020, and prescriptions prepared by 3 masters of Chinese medicine and 4 well-known Chinese medicine experts. […] These information were selected according to the inclusion and exclusion criteria, and EpiData 3.0 software was used to establish the &quot;Traditional Chinese Medicine Prescription Library for the Prevention and Treatment of COVID-19&quot; and the &quot;Common Database of Traditional Chinese Medicine for the Prevention and Treatment of COVID-19&quot;. […] Staged medication and local conditions need attention during the identification and treatment of COVID-19 clinical syndromes. 2020-04-14
32281334 Traditional Chinese medicine(TCM) has been recommended for the treatment of COVID-19 in Novel Coronavirus Pneumonia Prevention and Control Strategy, which have made outstanding contributions to the prevention and control of the epidemic. […] The wide application of Chinese medicine asked the pharmacists and doctors, nurses, and medical technicians in Wuhan and around the country to stand on the front line of COVID-19 treatment, and provide pharmaceutical care services, which has effectively guaranteed the safety and rational use of Chinese medicine. […] This article will introduce the TCM cognition of the COVID-19, analyze the clinical application of Chinese medicine and the entry point of pharmaceutical care, and clarify that clinical Chinese pharmacists can participate in making medication therapy plan, medication reconciliation, and prescription review, promoting rational drug use, pharmaceutical monitoring, and drug risk management. […] The participation of clinical Chinese pharmacists in the prevention and treatment of COVID-19 is conducive to improving the level of rational use of TCM, by ensuring the effectiveness, and safety. 2020-04-14
32281335 However, there have not been any effective drugs for treatment, with symptomatic treatment and prevention prevailing. […] The treatment plans of severe acute respiratory syndrome(SARS) and Middle East respiratory syndrome(MERS) are often used for reference in clinic. […] The advantages of traditional Chinese medicine(TCM) in treating SARS and MERS are that it can intervene and block the progression of disease in early stage, significantly reduce symptoms, shorten the treatment duration of patients, reduce complications and side effects caused by hormone therapy. […] Chinese patent medicines and prescriptions in medical observation and clinical treatment were recommended in the &quot;pneumonia diagnosis and treatment plan for new coronavirus infection&quot;(trial version fifth) of the National Health Commission of the People’s Republic of China. […] Qingfei Paidu Decotion was recommended for the treatment of COVID-19 by the National Health Commission of the People’s Republic of China and National Administration of Traditional Chinese Medicine. […] TCM shows good clinical efficacy and great potential in the treatment of COVID-19. […] In this paper, we reviewed traditional Chinese medicines and its active ingredients in the hope of bringing novel inspirations to the drug screening and clinical treatment for COVID-19. 2020-04-14
32281481 This study provides information on the main toxicological and epidemiological aspects to be considered for prophylaxis or treatment of COVID-19 using CQ but mainly HCQ, which is a less toxic derivative than CQ, and was shown to produce better results in inhibiting proliferation of SARS-CoV-2 based upon preliminary tests. 2020-04-16
32281667 " 1 which report the clinical features, diagnosis and treatment of the novel Coronavirus Disease 2019 (COVID-19). 2020-04-13
32281674 Mucosa exposure and inappropriate treatment of medical and non-medical articles used by the patients all could increase the risks of COVID-19 transmission. 2020-04-13
32281695 Based on the idea of host-directed therapy (HDT), we performed a negative co-expression analysis using big data of 60 000 Affymetrix expression arrays and 5000 TCGA data sets to determine the functions of TAS2R10, which can be activated by numerous bitter substances. […] To quickly guide the clinical treatment of 2019-nCoV, we searched currently available drugs that are agonists of TAS2Rs. 2020-04-13
32281757 However, as Covid-19 is an emerging disease, more work is needed to improve prevention, diagnosis and treatment strategies. […] It is essential to avoid nosocomial spread; in order to control and reduce the rate of infections it is necessary to strengthen the management of medical and nursing personnel through the early diagnosis, isolation and treatment of patients undergoing dialysis treatment. […] We cover here a series of recommendations for the treatment of dialysis patients who are negative to the virus, and of those who are suspected or confirmed positive. 2020-04-16
32282022 The pandemic of coronavirus disease 2019 (COVID-19) caused by the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) presents an unprecedented challenge to identify effective drugs for prevention and treatment. […] The most promising therapy is remdesivir. 2020-04-13
32282359 Large numbers of people are predicted to become critically ill with acute respiratory distress syndrome (ARDS) and will require management in intensive care units (ICUs). 2020-04-13
32282372 Here he considers the implications of exemplary innovations-virtual care, hospital at home, advances in diagnosis and therapy, virtual learning, and virtual clinical learning-for regulators, academic medical centers, faculty, and students. 2020-04-13
32282502 No established treatment is currently available; however, several therapies, including remdesivir, hydroxychloroquine and chloroquine, and interleukin (IL)-6 inhibitors, are being used off-label and evaluated in ongoing clinical trials. 2020-04-13
32282614 The pandemic of coronavirus disease 2019 (COVID-19) has unique implications for the anesthetic management of endovascular therapy for acute ischemic stroke. […] The Society for Neuroscience in Anesthesiology and Critical Care appointed a task force to provide timely, consensus-based expert recommendations using available evidence for the safe and effective anesthetic management of endovascular therapy for acute ischemic stroke during the COVID-19 pandemic. 2020-04-13
32282863 In this minireview, we provide a brief introduction of the general features of SARS-CoV-2 and discuss current knowledge of molecular immune pathogenesis, diagnosis and treatment of COVID-19 on the base of the present understanding of SARS-CoV and MERS-CoV infections, which may be helpful in offering novel insights and potential therapeutic targets for combating the SARS-CoV-2 infection. 2020-04-16
32282974 State-run hospitals and clinics are already overstressed by continuous demand for treatment of vector-borne diseases and community-acquired infections as well as high rates of non-communicable diseases. […] As ethical expertise in Latin America focuses on research ethics, few hospitals in the region have functioning clinical ethics committees or clinical ethics policy, forcing healthcare personnel to make excruciating treatment decisions in an environment dominated by material scarcity and public distrust. 2020-04-14
32282986 Following a treatment regimen consisting of discontinued immunosuppressant use and low-dose methylprednisolone-based therapy, the patient developed acute rejection but eventually recovered. […] His treatment regimen consisted of reduced immunosuppressant use. 2020-04-13
32282991 We report a case of a 32-year-old KTR who developed SARS-CoV-2 infection and fully recovered in 15 days while maintaining standard immunosuppressive therapy. 2020-04-13
32282993 We would like to thank the authors for their insightful thoughts on the consideration of anticoagulants and treatment for haemophilia A and B during the COVID-19 pandemic. 2020-04-13
32283108 Viral RNA-dependent RNA polymerases (RdRp) play essential roles in viral RNA synthesis, and thus remains the target of choice for the prophylactic or curative treatment of several viral diseases, due to high sequence and structural conservation. […] To date, the most promising broad-spectrum class of viral RdRp inhibitors are nucleoside analogues (NAs), with over 25 approved for the treatment of several medically important viral diseases. 2020-04-16
32283143 The cycle threshold values of open reading frame 1ab and nucleocapsid genes by RT-PCR assay were monitored during antiviral therapy. 2020-04-13
32283144 An outbreak of novel coronavirus in 2019 threatens the health of people, and there is no proven pharmacological treatment. […] The result indicated that critical patients were more likely to require corticosteroids therapy (risk ratio [RR]=1.56, 95% confidence interval [CI]=1.28-1.90, P<0.001). […] However, corticosteroid treatment was associated with higher mortality (RR=2.11, 95%CI=1.13-3.94, P=0.019), longer length of stay (weighted mean difference [WMD]=6.31, 95%CI=5.26-7.37, P<0.001), a higher rate of bacterial infection (RR=2.08, 95%CI=1.54-2.81, P<0.001), and hypokalemia (RR=2.21, 95%CI=1.07-4.55, P=0.032) but not hyperglycemia (RR=1.37, 95%CI=0.68-2.76, P=0.376) or hypocalcemia (RR=1.35, 95%CI=0.77-2.37, P=0.302). 2020-04-13
32283152 This article reviews the occurrence mechanism and treatment strategies of the COVID-19 virus-induced inflammatory storm in attempt to provide valuable medication guidance for clinical treatment. 2020-04-13
32283185 There were somewhat lower rates chronic GVHD (HR=0.78, 0.61-0.99, p=0.04) and DFS (HR for treatment failure=1.19, 95%CI=1.01-1.29, p=0.04) with graft cryopreservation that were of marginal statistical significance after adjusting for multiple comparisons. 2020-04-13
32283217 The first chest X-ray (faint bilateral patchy opacities) and CT scan (some faint subpleural ground-glass opacities associated with pleural thickening) were not typical for initial COVID-19 pulmonary infection, however, the treatment for COVID-19 was started. 2020-04-16
32283219 As COVID-19 cases increase throughout the country and healthcare systems grapple with the need to decrease provider exposure and minimize personal protective equipment (PPE) use while maintaining high quality patient care, our specialty is called upon to consider new methods of delivering inpatient palliative care. […] Telepalliative medicine has been used to great effect in outpatient and home-based palliative care, but has had fewer applications in the inpatient setting. […] We describe our rapid and ongoing implementation of telepalliative medicine consultation for our inpatient palliative care teams and discuss lessons learned and recommendations for programs considering similar care models. 2020-04-16
32283220 As palliative care and other health care providers become overwhelmed with patients critically ill with COVID-19, and routine care becomes delayed, we have a charge to recognize and work with family caregivers. 2020-04-14
32283324 Since severe complications in adults are frequently caused by uncontrolled immune responses and a resulting “cytokine storm” that may be controlled by targeted blockade of cytokines, previously established treatment with immunosuppressive treatments may indeed protect children from complications. 2020-04-16
32283325 We aimed to clarify the features of COVID-19-related liver damage to provide references for clinical treatment. 2020-04-13
32283815 At the moment, there is no specific antiviral treatment recommended for the COVID-19 pandemic and the therapeutic strategies to deal with the infection are only supportive. 2020-04-15
32284379 In sum, we demonstrate the importance of potassium ions to virus infection, suggesting a potential therapeutic target to disrupt virus replication.Importance No antivirals are approved for the treatment of bunyavirus infection. 2020-04-14
32284951 On behalf of the Society of Infectious Diseases Pharmacists, we herein summarize the current evidence as of March 18, 2020 to provide guidance on potential COVID-19 treatment options. […] It is important to caution readers that new data emerges daily regarding clinical characteristics, treatment options, and outcomes for COVID-19. […] Optimized supportive care remains the mainstay of therapy, and the clinical efficacy for the subsequent agents is still under investigation. 2020-04-16
32285293 This article will summarize the role of ACE2 in multiple organ damage caused by COVID-19 and SARS-CoV, targeted blocking drugs against ACE2, and drugs that inhibit inflammation in order to provide the basis for subsequent related research, diagnosis and treatment, and drug development. 2020-04-14
32285338 Few studies have been performed on viral transmission during surgery, but to date there is no study that demonstrates or can suggest the ability for a virus to be transmitted during surgical treatment whether open or laparoscopic. 2020-04-14
32285555 Intensive care units are facing a surge of patients requiring invasive ventilation.It is likely that requests for a tracheostomy in COVID-19 ventilated patients will soon come our way. 2020-04-14
32285930 Hydroxychloroquine (HCQ) is a promising candidate for Coronavirus Disease of 2019 (COVID-19) treatment. […] Our goal was to integrate historic and emerging pharmacological and toxicity data to understand safe and efficacious HCQ dosing strategies for COVID-19 treatment. […] HCQ doses > 400 mg BID for ≥5 days were predicted to rapidly decrease viral loads, reduce the proportion of patients with detectable SARS-CoV-2 infection, and shorten treatment courses, compared to lower dose (≤400 mg daily) regimens. 2020-04-14
32285949 Chest computed tomography (CT) showed different abnormalities from those of conventional COVID-19, and the faster absorption of pulmonary lesions also highlights the importance of antiretroviral therapy in this patient. […] This report provides reference for the diagnosis and treatment of HIV-infected patients with COVID-19. 2020-04-14
32286679 A significant number of patients with pneumonia require passive oxygen therapy. […] Non-invasive ventilation and high-flow nasal oxygen therapy can be applied in mild and moderate non-hypercapnia cases. […] Specific pharmacological treatment for COVID-19 is not currently available. […] The key is a holistic approach to the patient including, primarily, the use of personal protective equipment to reduce the risk of further virus transmission, as well as patient management, which consists in both quarantine and, in the absence of specific pharmacological therapy, symptomatic treatment. 2020-04-14
32286766 This review analyzes information from worldwide research and experience on the epidemiology, prevention, and treatment of COVID-19, and offers links to the most reliable and trustworthy resources to help equip healthcare professionals in managing this public health challenge. 2020-04-14
32286790 The proposed peptide inhibitors could provide simple and efficient therapeutics against the COVID-19 disease. 2020-04-16
32286947 This pandemic emphasizes the need to be constantly alert to shifts in both the global dynamics and the contexts of individual countries, making sure that all are aware of which approaches are successful for the prevention, containment and treatment of new diseases, and being flexible enough to adapt the responses accordingly. 2020-04-14
32287140 All patients were confirmed by real-time polymerase chain reaction and were analyzed for clinical characteristics, laboratory data, and treatment. […] Patients with digestive symptoms had higher mean liver enzyme levels, lower monocyte count, longer prothrombin time, and received more antimicrobial treatment than those without digestive symptoms. 2020-04-14
32288414 Following Law of the People’s Republic of China on Prevention and Treatment of Infectious Diseases and other related regulations, medical institutions have been authorized to collect the detailed information of patients, while it is still a formidable task in megacities because of the significant patient mobility and the existing information sharing barrier. 2020-04-16
32289016 We searched 7 data sources for eligible traditional medicine guidelines up to March 6, 2020 and found a total of 28 traditional medicine guidelines that provide treatment measures for COVID-19. […] This review can be used as guidance for the traditional medicine treatment of COVID-19. 2020-04-16
32289376 Although the treatment and protective standards are continuously evolving, this commentary shares our thoughts on how an institution, specifically surgical services may develop collaborative process improvement to accommodate for rapid and ongoing change. 2020-04-16
32289472 Management is predominantly focused on the provision of supportive care, with oxygen therapy representing the major treatment intervention. […] Medical therapy involving corticosteroids and antivirals have also been encouraged as part of critical management schemes. […] However, there is at present no specific antiviral recommended for the treatment of COVID-19, and no vaccine is currently available. 2020-04-16
32289548 We need an effective treatment to cure COVID-19 patients and to decrease virus carriage duration. […] Furthermore, the cost of treatment is negligible. 2020-04-16
32289565 All patients were given antiviral therapy. 2020-04-16
32289791 Using Richardson and Davidson’s model and the sciences of pharmacokinetics and clinical pharmacopsychology, this article reviewed the: (1) poor life expectancy associated with treatment-resistant schizophrenia (TRS), which may be improved in patients who adhere to clozapine; (2) findings that clozapine is the best treatment for TRS (according to efficacy, effectiveness and well-being); and (3) potential for clozapine to cause vulnerabilities, including potentially lethal adverse drug reactions such as agranulocytosis, pneumonia, and myocarditis. 2020-04-14
32290293 Although our understanding of coronaviruses has undergone a huge leap after two precedents, the effective approaches to treatment and epidemiological control are still lacking. 2020-04-16
32290643 To summarize the administration model of a COVID-19 designated hospital transformed from a community hospital to improve the emergency capacity of community hospitals and the efficiency of diagnosis and treatment of medical staff in the COVID-19 pandemic. […] Analyze the surrounding environment, ward layout, area management, treatment process, medical staff and patient management of the designated community hospital. […] Its diagnosis and treatment model has completed the treatment of COVID- 19 patients successfully. […] After adjustment, this community hospital can shoulder the critical task of being a designated hospital for COVID-19, which includes admission, isolation, and therapy of suspected and mild COVID-19 patients, reducing the medical burden of superior hospitals. 2020-04-15
32290754 Cancer patients represent a vulnerable population due to the acquired immunodeficiency associated with anti-cancer therapy. 2020-04-15
32290839 Moreover, Tocilizumab treatment that blocking IL-6 receptors showed inspiring clinical results including temperature returned to normal quickly and respiratory function improved. […] Therefore, we suggest that Tocilizumab is an effective treatment in severe patients of COVID-19 to calm the inflammatory storm and reduce mortality. 2020-04-16
32291076 Our discovery provides clues for pathogenesis and targeted drug therapy towards ACE2 expression for prevention and adjuvant therapy of COVID-19. 2020-04-15
32291112 Here, we review currently registered interventional clinical trials for the treatment and prevention of COVID-19 to provide an overall summary and insight into the global response. 2020-04-15
32291505 However, about 5% become critically ill and require intensive care treatment. […] To date there is no specific treatment available-the main goal of supportive therapy is to ascertain adequate oxygenation. 2020-04-15
32291526 This editorial presents the available evidence to guide treatment practices during this pandemic. 2020-04-16
32291542 In this review, we summarized the epidemiological characteristics, clinical features, diagnosis, treatment, and prognosis of COVID-19. 2020-04-15
32291906 Thus they suggested the anticoagulant treatment in patients with coronavirus disease 2019 (COVID-19). 2020-04-15
32291968 Patients with cancer are more likely than the general population to contract COVID-19 because of the systemic immunosuppressive status caused by malignant diseases or anticancer treatment. […] Most patients with lung cancer are smokers with poor underlying lung conditions and low immunity, thus it is vital to protect them from epidemic diseases during cancer treatment. […] It is necessary to provide individualized medical treatment and management of treatment-related adverse events for patients with lung cancer based on patients’ conditions and regional epidemic patterns. 2020-04-15
32292012 Objective: Todiscuss the the effects, indications and protective measures of tracheotomy for severe cases of 2019 novel corona virus disease(COVID-19)patients. Methods: A retrospectively analyze was conducted to explore the clinical data of ofCOVID-19 patients who received tracheotomy in February to March 2020,descriptive statistics were used to analyze the indication of tracheotomy, particularity of intraoperative treatment and protective measures. Results: A total of 4 cases were included in this article, 3 cases were successfully operated, 1 case of postoperative incision continuous bleeding, there were not other complications and nosocomial infection among the medical staff.the patient’s condition was relieved in different degrees after the operation, who remain hospitalized. Conclusion: Tracheotomy for severe cases of COVID-19 can achieve certain curative effect, but the occurrence of tracheotomy related complicationsand nosocomial infection should be effectively controlled, and the risk benefit ratio of tracheotomy should be carefully weighed before surgery. 目的: 探讨新型冠状病毒肺炎危重型患者施行气管切开术的指征、术中处理的特殊性及防护措施。 2020-04-15
32292113 In this commentary, we offer an alternative promising therapy for COVID-19, that is, mesenchymal stem cells (MSCs) transplantation. 2020-04-15
32292205 The COVID-19 epidemic should be considered a global threat and the steps for control include early diagnosis and treatment, as well as isolation. 2020-04-15
32292260 Several dental care facilities in affected countries have been completely closed or have been only providing minimal treatment for emergency cases. […] However, several facilities in some affected countries are still providing regular dental treatment. 2020-04-15
32292517 Three kinds of responses to clinical treatment were defined and evaluated: 1) good, symptoms continually improved; 2) fair, symptoms not improved or relapsed; 3) poor, symptoms aggravated. […] The progression in abnormal imaging findings indicate a poor/fair response, whereas the alleviated symptoms seen from CT suggest a good response. Conclusion: Most cases are no-emergency type and have a favorable response to clinical treatment. […] Follow-up CT changes during the treatment can help evaluate the treatment response of patients with NCP. 2020-04-16
32292529 As the epicentre of the initial outbreak, China has been updating the National COVID-19 Diagnostic and Treatment Guideline with up-to-date information about the disease. 2020-04-15
32292587 Our study aimed to present an overview of the virus in terms of structure, epidemiology, symptoms, treatment, and prevention. 2020-04-15
32292627 Collectively, these results suggest that MSCs significantly improve survival rate of H7N9 induced ARDS and provide a theoretical basis for the treatment of H7N9 induced ARDS in both preclinical research and clinical studies. […] Because H7N9 and the corona virus disease 2019 (COVID-19) share similar complications (such as ARDS and lung failure) and corresponding multi-organ dysfunction, MSC-based therapy could be a possible alternative for treating COVID-19. 2020-04-15
32292632 By taking these strategies, the hospital effectively improved the coping capacity of the nursing team and played a positive role in the prevention and treatment of COVID-19. 2020-04-15
32292634 This consensus included nursing assessment, nursing priorities, nursing goals, and thirteen key points of nursing procedures such as nursing of oxygen therapy and respiratory nursing. 2020-04-15
32292636 This article aims to summarize a series of contingency management strategies of the Nursing Department in the centralized treatment of patients with coronavirus disease 2019(COVID-19). […] The strategies of the Nursing Department included early warning for prevention and control, taking functions of vertically commanding and horizontally coordinating, and reasonably allocating nursing workforce, to facilitate centralized treatment work in the in-hospital fever clinic, isolation wards and ICU, and referral and admission of critical patients. […] Through the implementation of these strategies, safe and efficient centralized treatment was ensured timely, orderly and sustainably. 2020-04-15
32292686 To date, there is no specific therapy for COVID-19. 2020-04-15
32292691 Using spatial panel models, we analyse the relationship between confirmed cases of COVID-19, deaths thereof, and recovered cases due to treatment. 2020-04-15
32292693 The current health crisis caused by COVID-19 is a challenge for oncology treatment, especially when it comes to radiotherapy. […] In order to treat patients safely while protecting medical teams, the entire health care system must optimize the way it approaches prevention and treatment at a time when social distancing is key to stemming this pandemic. […] All indications and treatment modalities must be re-discussed. […] In this short piece, the members of the GEMO (the European Study Group of Bone Metastases) offer a number of recommendations to achieve the above objectives, both in general and in relation to five of the most common situations on radiation therapy for bone metastases. 2020-04-15
32292697 Osteonecrosis of the femoral head (ONFH) is a common disabling complication among convalescent SARS patients who received corticosteroid therapy. […] In China, a considerable number of convalescent SARS patients with steroid-associated ONFH had undergone conservative treatment by Traditional Chinese Medicine (TCM), and this study aims to evaluate the long-term results of a spleen-invigorating Huo-Gu Formula (HGF) therapy in these patients. and methods: A total of 33 convalescent SARS patients (nine males and 24 females) with bilateral steroid-associated ONFH (66 hips) were enrolled in this study. […] All patients received oral HGF therapy for six months when they were confirmed the diagnosis of steroid-associated ONFH. […] Based on average 14 years of follow-up of HGF therapy (ranging from six to 16 years), 38 hips (57%) among the 66 hips developed definite osteoarthritis, and 14 hips (26%) in 53 pre-collapse hips (ARCO stage I or II) progressed to femoral head collapse(ARCO stage III or IV). […] Chinese herbal HGF therapy demonstrates beneficial effects on preventing femoral head collapse, delaying total hip arthroplasty (THA)surgery, and maintaining physical function in the treatment of steroid-associated ONFH. […] HGF therapy might be therefore a good alternative for the treatment of steroid-associated ONFH secondary to rheumatologic and infection diseases. 2020-04-15
32292802 In addition we have also provided information about transmission dynamics, prevention measures and treatment options that are available at the present. […] Joint efforts of global scientific community are needed at this hour in terms of enhancement of research on development of accurate diagnostics, antiviral therapeutics and finally into formation of an effective vaccine against the emerging novel coronavirus. 2020-04-15
32292805 Unfortunately, for most of them, the drug products available on the market are not designed to be administered by a nasogastric tube to inpatients of intensive care units. 2020-04-15
32292817 We have studied its use as an antimalarial, an antiviral, and an immunomodulating drug and concluded that the use of HCQ at does matching that of the standard treatment of Systemic Lupus erythematous, which has proven safety and efficacy in terms of HCQ blood and tissue concentration adapted to bodyweight (2,3), at 6 mg/kg/day 1 (loading dose) followed by 5 mg/kg/day, with a maximum limit of 600 mg/day in all cases should swiftly be clinically evaluated as a post-exposure drug for exposed people. 2020-04-15
32292826 While there is no intervention for the prevention or treatment of COVID-19 with proven clinical efficacy to date, tools to distil the current research landscape by intervention, level of evidence and those studies likely powered to address future research questions is essential. 2020-04-15
32292839 During a global pandemic the benefit of routine visits and treatment of cancer patients must be weighed against the risks to patients, staff, and society. […] Treatment can be avoided or delayed until safe for very low, low, and favorable intermediate-risk disease. […] Unfavorable intermediate-risk, high-risk, clinical node positive, recurrence post-surgery, oligometastatic, and low-volume M1 disease can receive neoadjuvant hormone therapy for 4-6 months as necessary. 2020-04-15
32292847 Dealing with the immense challenge of COVID-19 disease, confronted with severely ill patients in dire straits with virtually no rigorous evidence base to guide our therapy, we must call upon our clinical skills and judgment. […] Lacking a robust evidence base, pathophysiologic reasoning can help guide our choices of therapy for individual clinical scenarios. 2020-04-15
32292848 We review the most current data with a focus on our basic understanding of the mechanism(s) of disease and translation to the clinical syndrome and potential therapeutics. 2020-04-15
32292866 During the first phase of the disease (from onset of the symptoms up to 7-10 days) viral-induced effects are prominent with the opportunity to institute antiviral therapy. 2020-04-15
32292904 The diagnosis, infection control, and treatment of COVID-19 in hemodialysis patients are discussed in this report, and we conclude with recommendations for how a dialysis facility can respond to COVID-19 based on our experiences. 2020-04-15
32292909 For this emergency, the FDA has approved Remdesivir and Hydroxychloroquine for treatment of COVID-19 as Emergency Use Authorization. 2020-04-15
32292917 We describe the percutaneous treatment of an unprotected left main coronary artery in a patient who is positive for coronavirus disease 2019 with unstable angina, dyspnea and fever. 2020-04-15
32293003 This raised multiple questions regarding a more severe course of COVID-19 in relation to hypertension itself as well as its treatment with renin-angiotensin system (RAS) blockers, e.g. angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin receptor blockers (ARBs). […] We also review in detail the molecular mechanisms linking the RAS to lung damage and the potential clinical impact of treatment with RAS blockers in patients with COVID-19 and a high cardiovascular and renal risk. 2020-04-15
32293020 Symptomatic (palliative) treatment is of fundamental importance both in conjuncture with life-sustaining interventions and in end of life care. […] Based on the evidence to date, there are several treatment options to consider for the relief of fever (acetaminophen, NSAID, oral glucocorticoids), cough (morphine), breathlessness (morphine, oxygen, fan), anxiety (benzodiazepines) and pain (NSAID, morphine). […] Top priorities include precautions to protect staff and people at-risk from infection and planning how to provide adequate treatment for each individual depending on setting, including palliative care. 2020-04-16
32293168 Thus, we have successfully fabricated a promising FET biosensor for SARS-CoV-2; our device is a highly sensitive immunological diagnostic method for COVID-19 that requires no sample pretreatment or labeling. 2020-04-15
32293713 In order to evaluate the efficacy of convalescent plasma therapy in COVID-19 patients, we did this timely descriptive study. 6 laboratory confirmed COVID-19 patients were enrolled and received the transfusion of ABO-compatible convalescent plasma. […] No obvious adverse effect observed during the treatment. […] In patient #1 and #5 who presented with SARS-CoV-2 in throat swab, convalescent plasma therapy elicited an elimination of virus. […] This study indicates that convalescent plasma therapy is effective and specific for COVID-19. […] This intervention has a special significance for eliminating SARS-CoV-2 and is believed to be a promising state-of-art therapy during COVID-19 pandemic crisis. 2020-04-15
32293714 The patient recovered after treatment and was discharged. 2020-04-15
32293715 A backlog of procedures after the end of the COVID-19 pandemic is inevitable, and hospitals should plan how to address this effectively to ensure that patients having elective treatment have the best possible outcomes. 2020-04-15
32293807 Several antiretroviral drugs are being considered for the treatment of COVID-19, the disease caused by a newly identified coronavirus, (SARS-CoV-2). […] We systematically reviewed the clinical outcomes of using antiretroviral drugs for the prevention and treatment of coronaviruses and planned clinical trials. […] From an initial screen of 433 titles, two randomized trials and 24 observational studies provided clinical outcome data on the use of antiretroviral drugs; most studies reported outcomes using LPV/r as treatment. […] Of the 21 observational studies reporting treatment outcomes, there were three studies among patients with SARS, six studies among patients with MERS and 12 studies among patients with COVID-19. 2020-04-16
32293831 The precautions to be taken against this virus, where our knowledge is extremely small, intensive care units take an indispensable place in pandemic planning. 2020-04-16
32293834 Currently, there is not any specific effective anti-viral treatment for COVID-19. […] Optimized supportive care remains the mainstay of therapy. […] Despite the urgent need to find an effective antiviral treatment for COVID-19 through randomized controlled studies, certain agents are being used all over the world based on either in-vitro or extrapolated evidence or observational studies. […] Nitazoxanide and ivermectin were also included in this review as they have recently been reported to have an activity against SARS-CoV-2 in-vitro and are licensed for the treatment of some other human infections. 2020-04-15
32293835 Unfortunately, there is no medication that has been approved by the FDA, gone through controlled studies and demonstrated an effect on the virus for this global pandemic. 2020-04-15
32293910 Appropriate treatment for heart failure, arrhythmias, acute coronary syndrome and thrombosis remain important. […] Specific evidence based treatment strategies for COVID-19 will emerge with ongoing global collaboration on multiple approaches being evaluated. 2020-04-15
32294179 Here we review the basic and clinical science spanning the intersections of diabetes, coronavirus infections, ACE2, and DPP4 biology, highlighting clinical relevance and evolving areas of uncertainty underlying the pathophysiology and treatment of T2D in the context of coronavirus infection. 2020-04-15
32294289 In this retrospective analysis, conducted at the Tongji Hospital of Wuhan, China, it is reported that heparin treatment reduces mortality in subjects affected by severe COVID-19 who have “sepsis-induced coagulopathy”. 2020-04-15
32294485 The severity on admission, complications, treatment, and outcomes of COVID-19 patients were evaluated. 2020-04-15
32294562 Several antiviral medications: Zanamivir, Indinavir, Saquinavir, and Remdesivir show potential as and 3CLPRO main proteinase inhibitors and as a treatment of COVID-19. […] It is also exciting to uncover that Flavin Adenine Dinucleotide (FAD) Adeflavin, B2 Deficiency medicine, and Coenzyme A, a coenzyme, may also be potentially used for the treatment of SARS-CoV-2 infections. […] The use of these off-label medications may be beneficial in the treatment of the COVID-19. 2020-04-15
32294763 The transfer of the patients after acute care treatment is needed urgently to facilitate the weaning process. […] In a next step we developed a triage algorithm to identify patients at SAVE intensive care units with potential to wean and transfer to weaning institutions - we called POST SAVE. […] This manuscript highlights the algorithms including the use of a standardised digital evaluation tool, the use of trained navigators to facilitate the communication between SAVE intensive care units and weaning institutions and the establishment of a prospective data registry for patient assignment and reevaluation of the weaning potential in the future. 2020-04-15
32294807 At present, there are no studies demonstrating the clinical efficacy of hydroxychloroquine for the prophylaxis or treatment of COVID-19 infection. 2020-04-15
32294811 The treatment of critically ill patients with coronavirus disease 2019(COVID-19) faces compelling challenges. […] In this issue, we’d like to share our first-line treatment experience in treating COVID-19. […] Nutritional support is the basis of treatment. […] It’s important to establish individual therapy regimens and to evaluate, monitor and adjust dynamically. 2020-04-17
32294813 As such, we developed this consensus recommendations on all those high-risk treatments, based on the current evidence as well as the resource limitation in some areas, with the aim to reduce the nosocomial transmission and optimize the treatment for the COVID-19 pneumonia patients. […] Those recommendations include: (1)Standard prevention and protection, and patient isolation; (2)Patient wearing mask during HFNC treatment; (3)Using dual limb ventilator with filters placed at the ventilator outlets, or using heat-moisture exchanger (HME) instead of heated humidification in single limb ventilator with HME placed between exhalation port and mask; avoid using mask with exhalation port on the mask; (4)Placing filter between resuscitator and mask or artificial airway; (5)For spontaneous breathing patients, placing mask for patients during bronchoscopy examination; for patients receiving noninvasive ventilation, using the special mask with bronchoscopy port to perform bronchoscopy; (6)Using sedation and paralytics during intubation, cuff pressure should be maintained between 25-30 cmH(2)O(1 cmH(2)O=0.098 kPa); (7)In-line suction catheter is recommended and it can be used for one week; (8)Dual-limb heated wire circuits are recommended and only changed with visible soiled; (9)For patients who need breathing support during transportation, placing an HME between ventilator and patient; (10)PSV is recommended for implementing spontaneous breathing trial (SBT), avoid using T-piece to do SBT. […] (11)Avoid unnecessary bronchial hygiene therapy; (12) For patients who need aerosol therapy, dry powder inhaler metered dose inhaler with spacer is recommended for spontaneous breathing patients; while vibrating mesh nebulizer is recommended for ventilated patients and additional filter is recommended to be placed at the expiratory port of ventilation during nebulization. 2020-04-17
32294816 The results showed that the positive rate of bronchoalveolar lavage for detection of new coronavirus nucleic acid was high, and bronchoalveolar lavage for suspected or confirmed new coronavirus pneumonia patients with negative detection of nucleic acid in pharynx swabs but still residual lung lesions was helpful for early diagnosis, treatment and prognosis. 2020-04-17
32294817 But the pathogenesis and treatment of the disease are not clear yet. 2020-04-17
32295300 To date, protease inhibitor drugs, especially HIV-1 protease inhibitors, have been available for human clinical use in the treatment of coronaviruses. 2020-04-17
32295322 Objective: To analyze the epidemiological characteristics and clinical features of the patients with 2019-nCoV infection in Nanyang City, so as to provide evidence for clinical diagnosis and treatment. Methods: The epidemiology, clinical symptoms, atory and radiologic data of 150 patients with 2019-nCoV infection admitted to the designated hospitals in Nanyang City from January 24,2020 to February 16, 2020 were retrospectively analyzed. Results: The 150 patients with 2019 nCov infection consisted of 67 men and 83 women, and the median age was 45±16 years; 69 of them were the first generation case,60 of them were the second generation case, 6 of them were the third generation case,the median incubation period of the first generation case was 5.4±2.2 days, and the second generation case was 6.7±3.1 days, and the first-generation cases are the majority in severe patients (69%) . […] After active treatment, 45% of patients were discharged according to discharge standards. 33% of sever and critically ill patients were discharged, 49% of them were degraded hospitalization.The average length of hospitalization was 12±4 days. Conclusion: A history of epidemiological exposure, fever, chest CT with signs of pneumonia, normal or decreased WBC, and lymphocytopenia, eosinophilia are the clinical basis for the diagnosis of this disease, and most of the sever patients were the first generation cases. 2020-04-16
32295323 Sleep study and non-invasive positive airway pressure (NIPAP) therapy can increase the risk of exposure and transmission of new coronaviruses to medical staff and patients. […] Based on the characteristics of sleep-disordered breathing, this consensus elaborates on the recommendations from the following four aspects that include patient and medical staff education, optimization of diagnostic and treatment protocols, sterilization of medical devices and the environment, and control of hospital-acquired infection. 2020-04-16
32295658 In this comment, we report the unexpected beneficial effect of a deployable rapid-assembly shelter hospital on the prevention and treatment of COVID-19. […] We describe the shelter hospital maintenance, treatment mode and primary treatment methods, which will provide a valuable experience in dealing with public health emergencies, such as COVID-19, for other countries and areas. 2020-04-30
32296259 One postexposure prophylaxis, convalescent (immune) plasma (CP), has shown some success in China and previously in the cure and therapy of other coronaviruses, SARS-1 and Middle East respiratory syndrome. 2020-05-31
32296735 In response to the outbreak of COVID-19 that has been sweeping the world, scientists reconstructed the SARS-CoV-2 rapidly using a synthetic genomics platform, in order to accelerate therapeutics and vaccine development. 2020-05-13
32296817 The few trials which allow their inclusion focus on post-exposure prophylaxis or outpatient treatment of milder disease, limiting the options available to pregnant women with severe COVID-19 to compassionate use of remdesivir, or off-label drug use of hydroxychloroquine or other therapies. […] In this Viewpoint, we call attention to the need and urgency to engage pregnant women in COVID-19 treatment trials now in order to develop data-driven recommendations regarding the risks and benefits of therapies in this unique but not uncommon population. 2020-04-30
32296824 Our nomogram could help clinicians to early identify patients who will exacerbate to severe COVID-19, which will enable better centralized management and early treatment of severe patients. 2020-04-30
32296888 For urology, the expansion of the health-care structures for the treatment of patients suffering from COVID-19 should be supported as best as possible. […] For this, patients must be prioritized individually, alternative therapy concepts must be considered and regional and supraregional cooperation must be used. […] Outpatient departments are of great importance in the care, examination and coordination of urological emergencies and urgent treatment. 2020-04-20
32296910 We propose several mechanisms by which coronavirus disease 2019 causes thrombocytopenia to better understand this disease and provide more clinical treatment options. 2020-05-22
32297089 The development of COVID-19 syndrome in anticoagulated patients, and especially their admission to intensive-care units with acute severe respiratory syndrome (SARS-CoV-2), expose them to specific problems related to their therapy, in addition to those associated with the acute viral infection. […] Patients on DOAC are exposed to under/over treatment caused by significant pharmacological interferences. […] In consideration of the pharmacological characteristics of oral anticoagulant drugs, the multiple pharmacological interactions due to the treatment of acute disease and the possible necessity of mechanical ventilation with hospitalization in intensive-care units, we suggest replacing oral anticoagulant therapies (VKA and DOAC) with parenteral heparin to avoid the risk of over/under treatment. 2020-05-10
32297571 Here we report on the most recent updates on experimental drugs successfully em-ployed in the treatment of the disease caused by SARS-CoV-2 coronavirus, also referred to asCOVID-19 (COronaVIrus Disease 19). […] Since the recoveries/deathsratio in the last weeks significantly increased, especially in China, it is clear that the experi-mental antiviral therapy, together with the availability of intensive care unit beds in hospitalsand rigorous government control measures, all play an important role in dealing with this vi-rus. 2020-04-21
32297671 After ‘five-in-one’ treatment, all patients were discharged with the exception of the four who died. 2020-04-30
32297723 At present, treatment of COVID-2019 is mostly based on the knowledge gained from the SARS and MERS outbreaks. […] Remdesivir, originally develop as a treatment for Ebola virus disease and Marburg virus infections, is being studied for it effectiveness against 2019-nCoV infection. 2020-04-20
32297727 The BCRSS uses patient examination features along with the need for escalating levels of respiratory support (NIV, intubation, proning) to suggest treatment recommendations. 2020-04-20
32297843 With few safe and effective drugs available to combat this threat to humanity and the normal functioning of our society, the oligonucleotide research community is uniquely positioned to apply its technology and expertise to help alleviate the crisis, thanks to its capacity for rational drug design, swift development cycles, and pursuing targets undruggable by conventional treatment strategies. 2020-05-29
32297985 Patients confirmed with COVID-19 pneumonia were enrolled and divided into 7 groups according to the treatment option. […] The chest CT imaging obtained at admission and after a 5-d treatment cycle were assessed. […] No significant differences were found among the groups in terms of the proportion of patients with pneumonia resolution (P=0.151) after treatment or the length of hospital stay (P=0.116). […] According to the results, the inclusion of antiviral drugs in therapeutic regimens based on symptomatic treatment had no significant additional impact on the improvement in COVID-19 patients. 2020-04-16
32297987 Particularly, no approved therapy has demonstrated to have an impact in treating patients who develop severe respiratory insufficiency so far. 2020-04-16
32297988 Treatment with HCQ resulted in less number of cases showing the radiological progression of lung disease (odds ratio [OR], 0.31, 95% confidence interval [CI], 0.11-0.9). […] No difference was observed in virological cure (OR, 2.37, 95% CI, 0.13-44.53), death or clinical worsening of disease (OR, 1.37, 95% CI, 1.37-21.97), and safety (OR, 2.19, 95% CI, 0.59-8.18), when compared with the control/conventional treatment. […] HCQ seems to be promising in terms of less number of cases with radiological progression with a comparable safety profile to control/conventional treatment. 2020-05-03
32298029 Patients who need to be hospitalized for cancer treatment were protected from potential SARS-CoV-2 infection by creating a dedicated diagnostic and therapeutic internal pathway for cancer treatment. […] Because of the extreme burden created by COVID-19, antitumor treatment was initiated only after considering patient performance status, comorbidities, biology of disease, and the likely impact of treatment on outcome. […] Treatment strategies were discussed in the context of a multidisciplinary tumor board. […] Treatment decision making balanced risk and benefits of treatment in the context of the specific pandemic level, on a case-by-case basis. 2020-04-27
32298036 Unique considerations for the head and neck patient are examined including risk to the oncology patient, outcomes following delay in head and neck cancer therapy, and risk of transmission during otolaryngologic surgery. 2020-05-29
32298139 Outbreaks generate geospatial “hotspots.” POC strategies help control hotspots, detect spread, and speed treatment of highly infectious diseases. Objectives. To stop outbreaks, accelerate detection, facilitate emergency response for epidemics, mobilize public health practitioners, enhance community resilience, and improve crisis standards of care. Data Sources. PubMed, WWW, newsprint, others were searched until COVID-19 was declared a pandemic, the US, a national emergency, and Europe, the epicenter. 2020-04-16
32298208 However, out-of-hospital professionals cannot access patient information, which has greatly reduced the efficiency of treatment; it is inconvenient for health care professionals to issue a case discussion with professionals from other wards. 2020-04-16
32298245 Actions such as social distancing are especially critical when medical countermeasures such as vaccines or therapeutics are not available. 2020-04-17
32298480 Infantile hemangiomas (IH) can require urgent evaluation and risk stratification to determine which infants need treatment and which can be managed with continued observation. […] For those requiring treatment, prompt initiation decreases morbidity and improves long-term outcomes. […] FDA/EMA-approved monitoring guidelines, clinical practice guidelines, and relevant, up-to-date publications regarding initiation and monitoring of beta-blocker therapy were used to inform the recommendations. […] Clinical decision-making guidelines about when telehealth is an appropriate alternative to in-office visits, including medication initiation, dosage changes, and ongoing evaluation, are included. […] The importance of communication with caregivers in the context of telemedicine is discussed, and online resources for both hemangioma education and propranolol therapy are provided. 2020-05-16
32298745 The patient avoided mechanical ventilation and acquired an immediate clinical and radiological improvement, after treatment of intensive plasma exchange (PE) followed by intravenous immunogloblin (IVIG). […] Successful therapeutic strategies in our case suggest timely initiating PE treatment followed by IVIG in critically ill patients with COVID-19 may prevent the disease from worsening and help to reduce the requirements for mechanical ventilation and intensive supportive care. 2020-05-05
32298748 We provide resources for health care providers, in addition to calling on palliative care providers to consider their own role as a resource to other specialties during this public health emergency. 2020-04-27
32298803 Fear of illness and uncertainty about the future precipitate anxiety- and stress-related disorders, and several groups have rightfully called for the creation and dissemination of robust mental health screening and treatment programs for the general public and front-line healthcare workers. 2020-04-24
32298807 The SARS-CoV-2 coronavirus (COVID-19) pandemic has significantly impacted the delivery of cellular therapeutics, including chimeric antigen receptor (CAR) T cells. […] Based on the collective experience of the CAR T-cell Consortium investigators, we review and address several questions and concerns regarding cellular therapy administration in the setting of COVID-19 and make general recommendations to address these issues. […] Specifically, we address (1) necessary resources for safe administration of cell therapies; (2) determinants of cell therapy utilization; (3) selection among patients with B cell non-Hodgkin lymphomas and B cell acute lymphoblastic leukemia; (4) supportive measures during cell therapy administration; (5) use and prioritization of tocilizumab; and (6) collaborative care with referring physicians. […] These recommendations were carefully formulated with the understanding that resource allocation is of the utmost importance, and that the decision to proceed with CAR T cell therapy will require extensive discussion of potential risks and benefits. […] Although these recommendations are fluid, at this time it is our opinion that the COVID-19 pandemic should not serve as reason to defer CAR T cell therapy for patients truly in need of a potentially curative therapy. 2020-05-05
32298981 PubMed database and Google Scholar were searched using the key terms ‘COVID-19’, ‘SARS-CoV-2’, ‘diabetes’, ‘antidiabetic therapy’ up to April 2, 2020. 2020-05-27
32298982 and Aims: No valid treatment or preventative strategy has evolved till date to counter the SARS CoV 2 (Novel Coronavirus) epidemic that originated in China in late 2019 and have since wrought havoc on millions across the world with illness, socioeconomic recession and death. 2020-05-29
32299202 Regretfully, the exact pathophysiology and treatment, especially for the severe COVID-19, is still uncertain. […] The results of preliminary studies have shown that immune-modulatory or immune-suppressive treatments such as hydroxychloroquine, interleukin (IL)-6 and IL-1 antagonists, commonly used in rheumatology, might be considered as treatment choices for COVID-19, particularly in severe disease. 2020-04-22
32299204 The case definition, finding out cases and first case cluster, proper treatment, sufficient stockpiles of medicine and population cooperation with the containment strategy should be considered for reduction of burden of pandemic. 2020-04-22
32299753 If baseline electrocardiographic testing reveals a moderately prolonged QTc, optimization of medications and electrolytes may permit therapy. 2020-05-18
32300516 Ultimately, treatment decisions should be made on the basis of dialogue between patient and provider, considering each patient’s individualized situation. 2020-05-16
32300673 Information on the variation of viruses is of considerable medical and biological impacts on the prevention, diagnosis, and therapy of infectious diseases. 2020-04-21
32300796 These similarities are explored here, and underscore the need to consider the role of basic biological mechanisms of aging on potential treatment and outcomes of COVID-19. 2020-04-30
32301099 We reported on the epidemiological, clinical, laboratory, and radiological characteristics of children cases to help health workers better understand and provide timely diagnosis and treatment. 2020-05-29
32301198 Here, we report the clinical features and our treatment approach for a kidney transplant patient with a diagnosis of COVID-19. 2020-05-22
32301284 Quantitative smell testing demonstrates that decreased smell function, but not always anosmia, is a major marker for SARS-CoV-2 infection and suggests the possibility that smell testing may help, in some cases, to identify COVID-19 patients in need of early treatment or quarantine. 2020-04-17
32301300 However, there is a risk of cross-infection at each stage of screening treatment, including the booths, and adverse reactions with disinfection of the booths. 2020-04-20
32301600 However, considering the initial data and lack of comprehensive knowledge on the pathogenesis of SARS-CoV-2 during pregnancy, human reproduction societies have recommended postponing the embryo transfers and do not initiate new treatment cycles. 2020-04-28
32301764 The pandemic of coronavirus disease 2019 (COVID-19) has several implications relevant to neuroanesthesiologists, including neurologic manifestations of the disease, impact of anesthesia provision for specific neurosurgical procedures and electroconvulsive therapy, and healthcare provider wellness. […] This consensus statement provides information on the neurological manifestations of COVID-19, advice for neuroanesthesia clinical practice during emergent neurosurgery, interventional radiology (excluding endovascular treatment of acute ischemic stroke), transnasal neurosurgery, awake craniotomy and electroconvulsive therapy, as well as information about healthcare provider wellness. 2020-05-22
32301766 We review current knowledge of the role of ACE2 in cardiovascular physiology and SARS-CoV-2 virology as well as clinical data to inform the management of patients with or at risk for COVID-19 who require renin-angiotensin-aldosterone system inhibitor therapy. 2020-05-16
32301817 For patients with developmental or chronic orthopaedic conditions, it may be possible to delay treatment for 2 to 4 months without substantial detrimental long-term impact. 2020-04-18
32301997 The patients were divided into three groups according to the “Diagnosis and Treatment of New Coronavirus Pneumonia (6th edition)” issued by the National Health Commission of China. 2020-04-30
32302058 Rapid and accurate laboratory testing of SARS-CoV-2 is essential for early discovery, early reporting, early quarantine, early treatment, and cutting off epidemic transmission. 2020-05-19
32302257 Finally, recommendations based on the Italian experience in terms of patient triage, patients’ entrance into the practice, dental treatment, and after-treatment management are reported and discussed. 2020-04-17
32302280 The National Institutes of Health is conducting a Phase 1 clinical trial to evaluate for a potential vaccine and the recipients have started to receive the investigational vaccine.2 We present a brief overview of the potential prophylactic and treatment agents under investigation, some which could be initiated in the ED if proven effective. 2020-05-21
32302411 It is primarily used for the treatment of respiratory, enteric, and genitourinary bacterial infections. […] AZ is not approved for the treatment of viral infections, and there is no well-controlled, prospective, randomized clinical evidence to support AZ therapy in coronavirus disease 2019 (COVID-19). […] Nevertheless, there are anecdotal reports that some hospitals have begun to include AZ in combination with hydroxychloroquine or chloroquine (CQ) for treatment of COVID-19. […] It is essential that the clinical pharmacology (CP) characteristics of AZ be considered in planning and conducting clinical trials of AZ alone or in combination with other agents, to ensure safe study conduct and to increase the probability of achieving definitive answers regarding efficacy of AZ in the treatment of COVID-19. 2020-05-12
32302419 Although COVID-19 does not have epidermotropism, cutaneous manifestations in Cov-19 positive patients have been reported [3] and departments of dermatology are considered at high risk [4] and were ordered to admit only patients needing urgent treatments or undergoing chronic immunosuppressive therapy in order to minimize nosocomial virus spread. 2020-04-17
32302438 These findings may explain the events of venous thromboembolism observed in some of these patients and support antithrombotic prophylaxis/treatment. 2020-04-17
32302448 Further studies are needed to assess the best prophylaxis and treatment of this condition. 2020-05-06
32302462 While we agree that this interim guidance addresses important considerations for monitoring the disease process, we believe that the proposed treatment strategy of prophylactic low molecular weight heparin (LMWH) to treat severe COVID-19 coagulopathy is an unconvincing strategy. 2020-04-17
32302681 Two pandemic scenarios, early (risk mitigation) and late (severely reduced radiation therapy resources), were evaluated. […] The panel developed treatment recommendations for 5 HNC cases. […] There was agreement or strong agreement across a number of practice areas, including treatment prioritization, whether to delay initiation or interrupt radiation therapy for intercurrent SARS-CoV-2 infection, approaches to treatment (radiation dose-fractionation schedules and use of chemotherapy in each pandemic scenario), management of surgical cases in event of operating room closures, and recommended adjustments to outpatient clinic appointments and supportive care. 2020-05-27
32302817 It has been associated with anxiety including multiple clinical activities, depression in the face of the coexistence of countless deaths, long work shifts with the most diverse unknowns and demands in the treatment with patients with COVID-19. 2020-05-19
32302954 Early detection and identification of critically ill patients is necessary to facilitate scientific classification and treatment. […] We collected and analyzed epidemiological, demographic, clinical, laboratory, radiological, and treatment data. 2020-05-27
32302966 The top three most popular themes were prevention and control procedures, medical treatment and research, and global or local social and economic influences, accounting for 32.57% (n=2538), 16.08% (n=1258), and 11.79% (n=919) of the collected reports, respectively. 2020-05-04
32303077 Because no treatment, no vaccine and no herd immunity exist, social distancing is the best mechanism available to protect patients and health care workers from infection. 2020-04-17
32303365 In this document we review two simple adjuvant therapies to administer, without side effects, and low cost that could be useful for the treatment of acute severe coronavirus infection associated with acute respiratory syndrome (SARS-CoV-2). […] VitaminC, a potent antioxidant, has emerged as a relevant therapy due to its potential benefits when administered intravenous. […] Another potential effective therapy is ozone: it has been extensively studied and used for many years and its effectiveness has been demonstrated so far in multiples studies. 2020-05-21
32303420 Specialties with overlap in therapies should have well defined arrangements among each other concerning the treatment spectra in order to avoid redundancy and loss of resources. 2020-05-12
32303485 In the context of the current pandemic, there is a need for specific advice concerning treatment of patients with Head and Neck cancers. 2020-05-22
32303497 One potential treatment is chloroquine and its derivatives, including hydroxychloroquine, which have both antiviral and anti-inflammatory effects. 2020-04-18
32303509 We discuss approaches to decrease the morbidity and mortality in patients with COVID-19 by repurposing existing drugs previously developed for cancer therapy. 2020-05-02
32303607 Further considerations are given to service provision, medical and surgical therapy, endoscopy, imaging and clinical trials. 2020-05-13
32303609 Moreover, the potential implications of these new insights for immunomodulation and biological therapy in IBD are discussed. 2020-05-14
32303672 His general practitioner suspected a urinary tract infection and prescribed him antibiotic therapy. […] After 2 days of antibiotic therapy the fever still persisted, so the individual was admitted to the local hospital and treated with broad-spectrum antibiotics. […] Considering the worsening of the chest X-ray and fever despite 48 h of broad-spectrum antibiotic therapy, we strongly suspected viral pneumonia. […] SARS-CoV-2 was detected and antiviral therapy with Lopinavir/Ritonavir, associated with hydroxychloroquine, was promptly started. […] Fever ceased after 2 days of therapy. […] Moreover, routine testing of patients who have to participate in therapy in common gym areas may be warranted. 2020-04-24
32303821 In the recommendations of the German Society for Rheumatology (, it is recommended that our patients continue the antirheumatic therapy to maintain remission or low state of activity despite the pandemic. […] In this study, patients with inflammatory rheumatic disease were asked in the first weeks of the pandemic on their opinion of their immunomodulating therapy. […] The result shows that over 90% of the patients followed the recommendation of the rheumatologist to continue the antirheumatic therapy, and only a small percentage of the patients terminated the therapy on their own. […] This result was independent of the individual anti-rheumatic therapy. 2020-05-08
32303885 All meet the indication for tracheal intubation announced by treatment expert group. 2020-05-08
32303925 These burdens can affect the physical, emotional, and social well-being of PLWH and interfere with the delivery of effective healthcare and access to HIV treatment. 2020-05-25
32304191 The epidemiological and clinical patterns of COVID-19 and treatment approaches in pediatric patients still remain unclear although many pediatric reports are published. […] This review aims to summarize the current epidemics, clinical presentations, diagnosis, and treatment of COVID-19 in pediatric patients. 2020-04-22
32304192 “COVID-19 Risk Assessment”, “COVID-19 Guideline” and “Case Report Form”, regulations of personal protective equipment along with need-based guidelines, treatment algorithms, brochures and related documents have been released. 2020-04-22
32304276 Urgent joined research efforts regarding the SARS-COV-2 rapid tests, accurate diagnosis, especially early recognition, and effective treatment of life-threatening complications would be highly desirable for humanity and medical workforce all over the world that try to combat a current global pandemic threat. […] Due to indirect complex effect, intensified COVID-19 therapies and multi-drug treatment, it is believed that some oral conditions could be aggravated by COVID-19 disease, particularly those with autoimmune aetiology, linked to compromised immune system or long-term pharmacotherapy. 2020-05-06
32304393 Thus, extreme caution and thoughtful approaches should be taken for a timely detection in delicate LVAD populations, especially if patients are living in a high-density COVID-19-infected area, and the potential intention for LVAD treatment is bridge to transplantation. 2020-05-30
32304394 Complications on the intensive care units include acute respiratory distress syndrome, acute cardiac- and kidney injury as well as shock.Here, we present the first case report of a successful treatment of a COVID-19 patient presenting with ARDS plus refractory combined cardiogenic and vasoplegic shock, which could be successfully stabilized after implantation of a percutaneous ventricular assist device (pVAD) plus an extracorporeal membrane oxygenation (ECMO). […] While such intense treatment might not be feasible in case of a health care disaster as described for the hot spots of the COVID-19 pandemic, it might encourage treatment of younger patients on intensive care units not overcrowded by critically ill patients. 2020-05-15
32304395 The outbreak of novel coronavirus (SARS-CoV-2) that causes the respiratory illness COVID-19 has led to unprecedented efforts at containment due to its rapid community spread, associated mortality, and lack of immunization and treatment. […] Through treatment targeting hyperinflammation, he recovered from critical COVID-19 respiratory failure and required only 160 hours of VV-ECMO support. 2020-05-30
32304402 In our critical cases, eight patients with relative volume of normal lung density smaller than 40% received mechanical ventilation for supportive treatment, and two of them had died. 2020-04-23
32304435 Currently, there is no specific treatment or approved vaccine against COVID-19 and many clinical trials are currently investigating potential medications to treat COVID-19. […] The immunosuppressed status of some cancer patients (whether caused by the disease itself or the treatment) increases their risk of infection compared with the general population. 2020-05-29
32304577 The incidence of venous thromboembolism among COVID-19 patients in intensive care units appears to be somewhat higher compared to that reported in other studies including such patients with other disease conditions. […] Preliminary data show that in patients with severe COVID-19, anticoagulant therapy appears to be associated with lower mortality in the subpopulation meeting sepsis-induced coagulopathy criteria or with markedly elevated d-dimer. 2020-05-04
32304643 A significant increase is expected in the number of imaging studies ordered for the initial diagnosis and treatment follow-up of cases of COVID-19. 2020-05-01
32304747 For these reasons ARB therapy must be continued for patients affected by hypertension, diabetes and renal disease, comorbidities of the current COVID-19 pandemic. […] Controlled clinical studies should be conducted to determine whether ARBs may be included as additional therapy for COVID-19 patients. 2020-05-20
32304772 Earlier identification, more intensive surveillance, and appropriate therapy should be considered in patients at high risk. 2020-05-28
32304822 None required antiviral therapy. 2020-05-20
32304970 Reprocessing PPE must consider material composition, functionality post treatment, along with appropriate disinfection. 2020-05-27
32305025 Epidemiological data and laboratory and imaging results were collected on the first day of admission, and analyzed based on the Diagnosis and Treatment Guideline for COVID-19 (5th edition, China). 2020-05-27
32305181 Prevention, diagnosis and treatment of malnutrition should therefore be routinely included in the management of COVID-19 patients. 2020-05-31
32305359 The coronavirus-19 (COVID-19) pandemic poses a significant risk to patients undergoing hematopoietic stem cell transplantation (HCT) or cellular therapy. […] The American Society for Transplantation and Cellular Therapy Pharmacy Special Interest Group Steering Committee aims to provide pharmacy practice management recommendations for how to transition clinical HCT or cellular therapy pharmacy services using telemedicine capabilities in the inpatient and outpatient settings to maintain an equivalent level of clinical practice while minimizing viral spread in a high-risk, immunocompromised population. […] In addition, the Steering Committee offers clinical management recommendations for COVID-19 in HCT and cellular therapy recipients based on the rapidly developing literature. 2020-05-29
32305401 Based on the anti-inflammatory benefits of the upregulation of the ACE2/Ang1-7/Mas axis and previously demonstrated benefits of lung function improvement in SARS-CoV infections, we hypothesize that the benefits of treatment with renin-angiotensin system inhibitors in SARS-COV2 may outweigh the risks and at the very least should not be withheld. 2020-04-21
32305585 In the present report, we have summarized a broad institutional consensus focusing on evaluation and recommended empirical therapy for COVID-19-positive patients. 2020-05-16
32305587 Although several drugs have been proposed as treatment options, there are no data on the effectiveness and safety of post-exposure prophylaxis (PEP) for COVID-19. 2020-04-29
32305589 The article emphases the possible drug candidates in the treatment of COVID-19 infection. 2020-04-24
32305831 Comorbidities, in particular, diabetes and hypertension, clearly associated with age, besides obesity and smoke, are strongly associated with the need for intensive treatment and a dismal outcome. […] We made a flash survey on COVID-19 incidence and severity among children on anticancer treatment. […] We also discuss preventive measures that are in place or should be taken and treatment options in immunocompromised children with COVID-19. […] While we should not underestimate the risk of developing a more severe course of COVID-19 than that observed here, the intensity of preventive measures should not cause delays or obstructions in oncological treatment. 2020-05-29
32305989 We do not recommend therapy for smoldering myeloma patients (standard or high risk). […] Screening for COVID-19 should be done in all patients before therapy. […] Patients on current maintenance should continue their therapy. 2020-05-16
32306015 The application of “Internet+medical treatment” in community medical institutions and synergy among various institutions should be promoted. 2020-04-22
32306118 This study provides a brief and precise review of the current knowledge regarding COVID-19, including disease transmission, clinical characteristics, diagnosis, and potential treatment. 2020-04-30
32306408 To assess the capacity of intensive care units (ICUs) in Australia to respond to the expected increase in demand associated with COVID-19. 2020-05-31
32306491 While some information is available, further studies are imperative for a more cohesive understanding of the cardiac pathophysiology in COVID-19 patients to promote more informed treatment and, ultimately, better clinical outcomes. 2020-04-19
32306513 Eventually, she adhered to guselkumab treatment. […] The compliance was excellent, significant improvements were observed after only 3 months of treatment, without adverse effects. […] In agreement with current Italian recommendations, risk and benefits profile was discussed with the patient’s legal tutor and the decision to continue the treatment was taken. 2020-04-29
32306597 Provided strict adherence to the epidemic prevention standards formulated by the state and professional societies, it is necessary to carry out clinical diagnosis and treatment as soon as possible. 2020-04-20
32306616 The prevention and treatment of coronavirus disease 2019 (COVID-2019) has reached the critical stage in China. 2020-04-20
32306657 Objective: To investigate the clinical features and outcome of treatment for novel coronavirus pneumonia. Methods: Literature on novel coronavirus pneumonia was retrieved from PubMed and EMBASE databases. […] Mechanical ventilation (13.4%), extracorporeal membrane oxygenation (1.9%), and continuous renal replacement therapy (3.8%) were used in severe cases. 2020-04-20
32307014 Therefore, the People’s Liberation Army Professional Committee of Critical Care Medicine and Chinese Society on Thrombosis and Hemostasis grouped experts from the frontline of the Wuhan epidemic to come together and develop an expert consensus on diagnosis and treatment of coagulation dysfunction associated with a severe COVID-19 infection. […] This consensus includes an overview of COVID-19-related coagulation dysfunction, tests for coagulation, anticoagulation therapy, replacement therapy, supportive therapy and prevention. 2020-04-23
32307151 The document provides clinical recommendations for the noninvasive respiratory support (noninvasive ventilation, high flow oxygen therapy with nasal cannula) in any patient with suspected or confirmed presentation of COVID-19 with acute respiratory failure. 2020-05-21
32307215 We found that approximately two-thirds of elective major uro-oncologic surgeries can be safely postponed or changed to another treatment modality when the availability of health care resources is reduced. 2020-04-22
32307245 Despite the worsening trends of COVID-19, no drugs are validated to have significant efficacy in clinical treatment of COVID-19 patients in large-scale studies. […] The roles of teicoplanin (which inhibits the viral genome exposure in cytoplasm) and monoclonal and polyclonal antibodies in the treatment of SARS-CoV-2 are under investigation. 2020-05-02
32307298 Timely diagnosis and treatment may be lifesaving. […] OBJECTIVE: To raise awareness about the importance of early diagnosis and treatment of HLH with neurological involvement to prevent serious complications and demise. 2020-04-23
32307313 Overall treatment time is an important factor of local recurrence and indirectly of distant evolution, namely in case of protracted treatments. […] The models used to compensate the total dose in case of temporary treatment interruption are well known but it is of importance in that pandemic context to update and homogenize clinical practice in order to improve local control without increasing normal tissue complications. 2020-04-26
32307319 The contribution of community pharmacists in these facilities to manage chronic conditions and promote medication adherence during this COVID-19 pandemic will be essential in easing the burden on already strained health systems. 2020-04-23
32307516 Little is known about treatment options to combat the novel virus, but the same applies to the effects of COVID-19 on people’s mental health. 2020-04-30
32307550 Here, we investigated the clinical, cytokine levels, T cell proportion and related gene expression occurring in COVID-19 patients on admission and after intial treatment. 11 patients diagnosed as COVID-19 with similar initial treatment regimen were enrolled in the hospital. […] IL-10 level was significantly varied with disease progression and treatment. […] The decreased T cell proportions were observed in COVID-19 patients especially in severe cases, and all elevated to normal in mild patiens after initial treatment but only CD4+T cells return to normal in severe cases. […] The number of DEGs increased with the disease progress, and decreased after initial treatment. […] Our findings show a decreased T cell proportion with down-regulated gene expression related to T cell activation and differentiation were occurred in COVID-19 severe patients, which may help to provide effective treatment strategies for COVID-19 . 2020-04-30
32307593 In the present article, we have summarized the promising drugs, adjunctive agents, respiratory supportive strategies, as well as circulation management, multiple organ function monitoring and appropriate nutritional strategies for the treatment of COVID-19 in the ICU based on the previous experience of treating other viral infections and influenza. 2020-04-23
32307653 The expressive number of deaths and confirmed cases of SARS-CoV-2 call for an urgent demand of effective and available drugs for COVID-19 treatment. 2020-05-29
32307905 The same disruptions can affect management of this vulnerable patient group, perhaps warranting early aggressive treatment. 2020-04-29
32307955 However, hemodialysis patients represent a unique group of patients, mostly elderly and immunocompromised, for whom dialysis is a life-saving treatment which cannot be stopped. 2020-04-21
32308263 The relevance of these interventions for the prevention and treatment of CoViD-19 is discussed. 2020-04-23
32308494 The patients received the following treatments: antiviral therapy (100%), Chinese medicine (76.92%), antibiotics (50%), gastric mucosal protection (19.23%), immunotherapy (7.69%), and glucocorticoids (3.85%). […] Most patients (25/26) required ≥1 treatment. 2020-04-23
32308732 Compound quercetin, luteolin, kaempferol, acacetin etc., were all involved in the treatment of various disease stages on the compound level both in generality and individuality. […] The CMs of ISRD improved patients’ recovery, suggesting the importance of regulating intestinal function and keeping microenvironmental balance in TCM treatment of NCP. 2020-04-23
32309679 Here we have provided a foundation for cardiovascular and cardio-oncology physicians who are on the frontline providing care to COVID-19 patients, so that they can better understand the emerging cardiovascular epidemiology of COVID-19, as well as the biological rationale for the clinical trials that are ongoing for the treatment of COVID-19 patients. 2020-05-31
32309809 The purpose of the current systematic review is to evaluate the efficacy of antiviral therapies in treatment of COVID-19. […] In addition, clinical trials on the efficacy of antiviral therapies in the management of Severe Acute Respiratory Syndrome coronavirus (SARS-Cov) or Middle East Respiratory Syndrome coronavirus (MERS-CoV) have also been reviewed, in order to identify potential treatment options for COVID-19. […] Only one clinical trial on the efficacy of antiviral therapy in management of COVID-19 was found. […] The results depicted that adding Lopinavir-Ritonavir to the standard treatment regimen of patients with severe COVID-19 has no benefits. […] The current evidence impede researchers from proposing an appropriate antiviral therapy against COVID-19, making the current situation a serious concern for international organizations such as World Health Organization (WHO). 2020-04-23
32309812 Among the introduced treatment methods for management of ARDS patients, prone position can be used as an adjuvant therapy for improving ventilation in these patients. 2020-04-23
32310190 No antiviral therapies or vaccines are available for their treatment or prevention. 2020-05-27
32310621 In this review, we summarize epidemiologic, clinical and diagnostic findings, as well as treatment and prevention options for common circulating and novel CoVs infections in humans with a focus on infections in children. 2020-04-24
32310920 The integrated clinical, laboratory and ultrasound approach is essential for the diagnosis, monitoring and evaluation of the patient’s therapy in COVID-19 pneumonia. 2020-04-22
32310921 If this, on one hand, results in reducing improper access to the ER and hospital, on the other hand it substantiates the risk of underestimating problems not connected to COVID-19, such as an increased delay in the diagnosis and treatment of acute myocardial infarction and other cardiovascular emergencies. 2020-04-22
32311114 Therapeutic decisions need, more than ever before, to be considered in the best interests of both patients, and society, while not denying function-preserving/restoring treatment. […] Immunoglobulin therapy and plasma exchange, for those treated outside of the home, expose patients to the hazards of hospital or outpatient infusion centers. […] Steroid therapy initiation and continuation pose increased infectious risk. […] Immunosuppressant therapy similarly becomes highly problematic, with the risks of treatment continuation enhanced by uncertainties regarding duration of the pandemic. 2020-04-24
32311151 The government should take emergent and effective measures to prevent and treatment of the pandemic disease. 2020-05-22
32311437 COVID-19 diagnostic criteria: according to China’s ⟪pneumonia diagnosis and treatment Program of novel coronavirus infection (trial version 7) ⟫, in accordance with the relevant epidemiological and clinical manifestations, nasopharyngeal swabs real-time fluorescence RT-PCR detection of 2019-nCoV nucleic acid positive, COVID-19 cases were divided into mild, ordinary, severe and severe [1]. […] RESULTS: | 132 the results of 2019-nCoV nucleic acid test of various biological samples during the treatment of confirmed COVID-19 cases are as follows: the positive rate of 2019-nCoV nucleic acid test of nasopharyngeal swab is 38.13% (180/472 times), the positive rate of 2019-nCoV nucleic acid test of sputum is 48.68% (148/304 times), the positive rate of blood 2019-nCoV nucleic acid test is 3.03% (4/132 times), and the positive rate of 2019-nCoV nucleic acid test of feces is 9.83% (24/244 times). […] Simple detection of nasopharyngeal swab 2019-nCoV nucleic acid detection positive rate is not high, multi-sample 2019-nCoV nucleic acid detection can improve the accuracy, reduce the false negative rate, better guide clinical treatment and evaluate the therapeutic effect. 2020-05-13
32311448 In addition, many patients receiving antithrombotic therapy for thrombotic disease may develop COVID-19, which can have implications for choice, dosing, and laboratory monitoring of antithrombotic therapy. 2020-04-23
32311643 Oncologists need to preserve the continuum of care of patients, as the benefit of ensuring a well-delivered anti-cancer treatment plan outweighs the risk of COVID-19 infection. 2020-05-29
32311668 Indeed, this test represents an important immunological tool aimed at identifying the precise phase of the infection in order to undertake a more appropriate pharmacological treatment. 2020-05-28
32311760 In both experiments, the measured titre of SARS-CoV-2 was below the limit of detection following treatment with riboflavin and UV light. 2020-05-14
32311826 In addition to its central role in the diagnosis of COVID-19 infection, the clinical laboratory provides critical information to clinicians regarding prognosis, disease course, and response to therapy. 2020-04-20
32311843 A large number of these patients end up in the intensive care units (ICU) with critical illness requiring mechanical ventilation. 2020-04-20
32312025 Computed tomography (CT) has been described as a diagnostic modality in the COVID-19 diagnosis and treatment plan. 2020-04-21
32312064 Here, we report a family cluster case of a father and a son diagnosed as COVID-19 at our hospital, and described the clinical manifestations, laboratory results, CT changes, diagnosis and treatment strategy of these two patients. […] Focus on the value of these two methods in the diagnosis and treatment of diseases, as well as their respective deficiencies. […] For patient 1 (father), the efficacy of RT-PCR is not satisfactory either in terms of diagnosis or follow-up, which may cause misdiagnosis and delay treatment. 2020-04-21
32312163 The medical complexity of head and neck cancer management may lead to prolonged delays that worsen treatment outcomes. 2020-04-21
32312290 Two patient groups were simulated (50,000 patients in each group); (1) Patients received tPA immediately upon diagnosis of ARDS and (2) patients received standard therapy for ARDS. 2020-04-23
32312363 Among the 115 children, 3 were critically ill, among whom 1 had been cured and the other 2 were under continuous treatment. 2020-04-22
32312365 Based on a literature review, this article discusses the possible cardiovascular system damage caused by SARS-CoV-2 in children and related mechanisms, in order to provide help for the timely treatment and prevention of cardiovascular system damage caused by SARS-CoV-2 in children. 2020-04-22
32312544 We provide treatment advice as a pragmatic perspective on the risk/benefit ratio in specific clinical scenarios. 2020-05-28
32312567 We could also face major issues in referring patients with acute mental disorders to intensive care units. 2020-05-08
32312568 The Chinese government has formally set COVID-19 in the statutory notification and control system for infectious diseases according to the Law of the People’s Republic of China on the Prevention and Treatment of Infectious Diseases. […] Based on our own experience and the guidelines on the diagnosis and treatment of COVID-19 (7th Version) with other regulations and literature, we describe our experience with suggestions for medical practices for burn units during the COVID-19 outbreak. 2020-04-23
32312600 The document provides clinical recommendations for the noninvasive respiratory support (noninvasive ventilation, high flow oxygen therapy with nasal cannula) in any patient with suspected or confirmed presentation of COVID-19 with acute respiratory failure. 2020-04-21
32312892 For patients already enrolled however, there are challenges in continuing treatment on trial. 2020-05-21
32312919 Therefore, determining the algorithm becomes crucial for qualifying patients for surgical treatment, but also to stratify the risk of personnel being infected during surgery and to adequately protect staff. 2020-04-22
32313463 Treatment is largely supportive, with regimens including antiviral therapy. 2020-04-23
32313660 To date, the anti-malaria drug hydroxychloroquine found to be a treatment option for SARS-CoV-2. […] In addition to supportive treatment, such as oxygen supply in moderate cases and extracorporeal membrane oxygenation in critically ill patients, unique medications for this condition are also under investigation. […] Here we reviewed the antibody therapy might be an immediate strategy for emergency prophylaxis and SARS-CoV-2 therapy. 2020-05-31
32313662 Lopinavir/ritonavir was given; continuous renal replacement therapy was also introduced. […] Treatment of severe pneumonia in COVID-19 by ECMO should recognize lung plasticity considering time to ECMO introduction and interstitial biomarkers. 2020-04-23
32313713 The infusion management group optimized the intravenous infusion workflow based on Hamer’s Process Reengineering Theory and applied it to the treatment of patients with coronavirus disease 2019. 2020-04-23
32313823 Presently, there is no specific treatment or vaccine but physicians are battling with the use of antibiotics, steroid, anti-viral and anti-HIV drugs and some of the infected cases are testified improved. 2020-04-23
32313824 No Food and Drug Administration approved treatment is available till date. […] In this review, we are tried to explore the epidemiology, pathogenesis and current treatment of CoVs infection. […] The promising therapeutics molecules against CoVs and future prospective have been also discussed which will be helpful for researchers to find out the new molecules for the treatment of CoVs disease. 2020-04-23
32313880 Since Louis Pateur who developed a vaccine against rabies in 1885, in general a series of “specific” vaccines have been used for treatment of viral infection, mainly because antibiotics in general are ineffective for treatment of viral infection. […] Thus, as alternative potentially more direct “broad-spectrum” COVID-19 therapeutics, several natural and synthetic PAK1-blockers such as propolis, melatonin, ciclesonide, hydroxy chloroquine (HQ), ivermection, and ketorolac, which are readily available in the market, are introduced here. 2020-04-23
32313883 In one human study, it was found that the treatment of severe H1N1 influenza‑related pneumonia with rapamycin and steroids improved the outcome. […] The inhalation of buformin or phenformin for influenza may be an effective novel treatment strategy that would limit the risk of systemic side-effects associated with biguanides due to the low inhaled dose. 2020-05-01
32313885 Here we have provided a foundation for cardiovascular and cardio-oncology physicians who are on the frontline providing care to COVID-19 patients, so that they can better understand the emerging cardiovascular epidemiology of COVID-19, as well as the biological rationale for the clinical trials that are ongoing for the treatment of COVID-19 patients. 2020-05-22
32314010 The patient was treated with antiviral agents (lopinavir/ritonavir), and treatment with cDMARDs was discontinued except hydroxychloroquine. 2020-05-04
32314034 With no proven vaccination or treatment, infection control measures are paramount. 2020-04-30
32314081 I submit that attention to COVID-19 pharmacologic therapy needs similar emphasis, including identifying any existing medications that can be repurposed to treat COVID-19 patients. 2020-05-01
32314460 COVID-19 is a challenge for the treatment of dermatologic patients, either with severe inflammatory disorders or with skin cancer. […] The consequences for systemic treatment are obvious but it will be most important to collect the clinical data for a better decision process. 2020-05-22
32314483 One of question is if psoriasis patients treated with immunomodulating and immunosuppressive drugs have to discontinue their treatment in the midst of fears for the infection and its consequences. 2020-05-22
32314698 Hydroxychloroquine (HCQ) has been used for the treatment of novel coronavirus disease (COVID-19) cases. […] Considering the significantly increased use of HCQ during the COVID-19 pandemic, this case alerts us to the potential for HCQ to be associated with hepatotoxicity and the need to monitor liver function during HCQ therapy. 2020-04-21
32314799 Tocilizumab is an interleukin-6 (IL-6) receptor antibody and is progressing as a viable and promising treatment option in patients with severe coronavirus disease 2019 (COVID-19). 2020-05-12
32314850 Focussing on immune regulators has treatment implications for covid-19 and other viral infections. 2020-05-19
32314951 We highlight the critical roles that pharmacists have related to sustaining and advancing the changes being made in the face of the current COVID-19 pandemic to ensure that patients have more seamless and less complex access to treatment. 2020-04-24
32315171 The recent outbreak of novel coronavirus disease-19 (COVID-19) calls for and welcomes possible treatment strategies using drugs on the market. 2020-05-07
32315386 He was given antibiotics for infection of unknown source, subsequently refined to treatment for community-acquired pneumonia. […] Despite active treatment, he deteriorated with oxygen desaturation and tachypnoea. 2020-04-30
32315487 Autoimmune phenomena exist in COVID-19 subjects, and the present results provide the rationale for a strategy of preventing immune dysfunction and optimal immunosuppressive therapy. 2020-05-14
32315614 Novel coronavirus (COVID-19) is highly infectious and requires early detection, isolation, and treatment. 2020-05-30
32315723 Additionally, the origin of COVID-19 has not been determined and no specific antiviral treatment or vaccine is currently available. 2020-05-16
32315725 Our findings may shed light on early warning of high risks of mortality and help early intervention and treatment of COVID-19. 2020-04-26
32315817 ARDS and ACI may be the main obstacles for patients to treatment recovery. 2020-05-27
32315874 Drawing on the 9/11 experience, we highlight effective prevention measures, likely short and long-term treatment needs, vulnerable subgroups, and important points of divergence between 9/11 and the COVID-19 pandemic. […] Mental health monitoring, early identification of at-risk individuals, and treatment irrespective of financial barriers are essential for minimizing chronic distress. 2020-05-19
32315948 A type 1 diabetes patient experienced remission associated with chloroquine therapy while travelling to a malaria-endemic area. 2020-05-27
32315980 However, it has been speculated that overactive immune response could drive clinical deterioration and, based on this hypothesis, several immunosuppressants are currently being tested as potential treatment for COVID-19. […] This report supports the putative role of immunosuppressive therapy in COVID-19 affected patients. 2020-05-26
32316065 Concomitant venous thromboembolism (VTE), a potential cause of unexplained deaths, has been frequently reported in COVID-19 cases, but its management is still challenging due to the complexity between antithrombotic therapy and coagulation disorders. 2020-05-06
32316233 Glucose-6-Phosphate Dehydrogenase (G6PD) deficiency screening test is essential for malaria treatment, control, and elimination programs. […] G6PD deficient individuals are at high risk of severe hemolysis when given anti-malarial drugs such as primaquine, quinine, other sulphonamide-containing medicines, and chloroquine, which has recently been shown to be potent for the treatment of coronavirus disease (COVID-19). […] Given the challenges associated with G6PD deficiency, it would be essential to improve access to G6PD deficiency POC testing to facilitate administration of sulphadoxine-pyrimethamine to pregnant women, full implementation of the malaria control program in Ghana, and treatment of COVID-19 patients with chloroquine in malaria-endemic countries. 2020-05-29
32316618 The purpose of this review is to provide a comprehensive update on the pathogenesis, clinical aspects, diagnosis, challenges and treatment of SARS-CoV-2 infections. 2020-05-29
32316712 The aims were to investigate medical needs of lung cancer patients and their mental health status during the epidemic periods, so as to provide rational recommendations for subsequent diagnosis and treatment. […] Of the 368 patients, 18 patients were excluded as they didn’t receive anti-tumor treatment, and 350 patients were included in the final analysis. 229 cases were treated with oral targeted drugs, and 121 cases were treated with chemotherapy or immunotherapy. […] 41.3% of patients treated with intravenous chemotherapy or immunotherapy experienced treatment discontinuation, and the proportion of treatment discontinuation in chemotherapy or immunotherapy was higher than those treated with oral targeted drugs (21.0%). […] 26.6%-28.9% of patients have changed their treatment plans through online consultation. 2020-05-16
32316718 A systematic search on PubMed, Pedro and Google Scholar was performed using the search terms: “Covid-19”, “Coronavirus”, “severe acute respiratory syndrome coronavirus 2”, “rehabilitation”, “physical therapy modalities”, “exercise”, “occupational therapy”, and “late complications”. 2020-04-22
32316751 There is currently no effective treatment or approved vaccine, so isolating the source of infection and blocking the routes of transmission is important. 2020-04-22
32316872 Timely and appropriate public health interventions addressing cultural impact and risk for stigmatization along with proper screening, treatment, and follow up for affected individuals and close contacts can reduce the number of infections, serious illness, and deaths. 2020-05-27
32317153 Drugs are the main treatment of COVID-19 patients. […] According to COVID-19 prevention and control policy and requirements, combined with series of diagnosis and treatment plans, pharmacists in the first provincial-level COVID-19 diagnosis and treatment unit in Jilin Province in Northeast China have established the management practices of drug supply and pharmaceutical care from four aspects: personnel, drugs supply management, off-label drug use management and pharmaceutical care. […] So far, no nosocomial infections and medication errors have occurred, which has stabilized the mood of the staff and boosted the pharmacists’ confidence in fighting the epidemic. […] For the treatment of COVID-19, pharmacists conducted adverse reaction monitoring and participated in the multidisciplinary consultation of COVID-19. 2020-04-24
32317180 Immunosuppressant reduction and low-dose methylprednisolone therapy. […] After a longer time of virus shedding (28.4 ± 9.3 vs 12.2 ± 4.6 d in the control group) and a longer course of illness (35.3 ± 8.3 vs 18.8 ± 10.5 d in the control group), nine of the 10 transplant patients recovered successfully after treatment. […] Findings from this small group of cases may have important implications for the treatment of COVID-19 pneumonia in immunosuppressed populations. […] Immunosuppressed transplant recipients with coronavirus disease 2019 infection had more severe pneumonia, but most of them still achieved a good prognosis after appropriate treatment. 2020-05-28
32317202 Hence, there is an urgent requirement for conducting academic research on several aspects of this highly contagious disease, to find effective means of containment and treatment of the disease, for now, and in future. 2020-04-24
32317205 In the current paper, we describe our successful treatment of three COVID-19 pneumonia patients cases including severe cases and cases with mortality risk factors. 2020-04-24
32317220 Several efforts are currently made to find a treatment for COVID-19 patients. […] The anti-viral aspect of immunosuppressants towards a variety of viruses has been known since long time and it is herein discussed in the view of searching for a potential treatment for SARS-CoV-2 infection. 2020-04-24
32317225 He was successfully treated in the intensive care unit with mechanical ventilation and extracorporeal membrane oxygenation for respiratory support; and antiretroviral treatment with lopinavir/ritonavir. 2020-04-24
32317267 Epidemiological, clinical, and laboratory characteristics and treatment and outcomes data were obtained through data collection forms from electronic medical records, and the relation between clinical data and disease severity was analysed. 3497 respiratory, stool, serum, and urine samples were collected from patients after admission and evaluated for SARS-CoV-2 RNA viral load. 2020-04-24
32317402 Our current treatment protocol appears to be associated with favorable outcomes, but longer follow-up of a larger cohort of patients is needed. 2020-05-30
32317408 In the absence of approved marketed drugs against coronaviruses, the treatment and management of this novel CoV disease (COVID-19) worldwide is a challenge. 2020-05-06
32317557 As COVID-19 cases surge worldwide, an urgent need exists to enhance our understanding of the role of extracorporeal membrane oxygenation (ECMO) in the management of severely ill patients with COVID-19 who develop acute respiratory and cardiac compromise refractory to conventional therapy. […] Adjunctive medication in the surviving patients while on ECMO was as follows: 4 of 5 survivors received intravenous steroids, 3 of 5 survivors received antiviral medications (Remdesivir), 2 of 5 survivors were treated with anti-interleukin-6-receptor monoclonal antibodies (Tocilizumab or Sarilumab), and 1 of 5 survivors received hydroxychloroquine.An analysis of 32 COVID-19 patients with severe pulmonary compromise supported with ECMO suggests that ECMO may play a useful role in salvaging select critically ill patients with COVID-19. 2020-05-15
32317558 The diagnosis was established through a remote interaction with the patient after early discharge from outpatient therapy due to upcoming traveling restrictions. 2020-05-26
32317808 The clinical knowledge about the course, complications and treatment of COVID-19 in children and adolescents is so far limited. 2020-04-24
32317810 It will help in designing a probiotic-based diet for modulation of the gut microbiome, and that could be another plausible prophylactic treatment option. […] Hence, the experiences from the clinical intervention for that region should be considered in control and treatment strategies. 2020-04-24
32318324 For example, treatment with iron chelator deferiprone has been shown to prolong the survival of acquired immunodeficiency syndrome (AIDS) patients. 2020-04-24
32318325 The objectives of this study were to analyze the clinical features of coronavirus disease 2019 (COVID-19) and evaluate the diagnosis and treatment. 2020-04-24
32318665 Rhesus macaque models infected with SARS-CoV-2 provided insight into the pathogenic mechanism and facilitated the development of vaccines and therapeutics against SARS-CoV-2 infection. 2020-05-19
32318706 The panel suggests a decision-making framework for antiviral therapy that weighs risks and benefits based on disease severity as indicated by respiratory support needs, with consideration on a case-by-case basis of potential pediatric risk factors for disease progression. […] Antiviral therapy for COVID-19 is not necessary for the great majority of pediatric patients. 2020-05-14
32318986 If a vaccine or a treatment is approved, we recommend a government control over its use to preserve the rights of the vulnerable and needy groups. 2020-05-01
32319129 While the world is facing an unprecedented pandemic with COVID-19, patients with chronic diseases need special attention and if warranted adaptation of their regular treatment plan. […] Optimal disease control of allergic, asthmatic and immunodeficient children should be sought according to usual treatment guidelines. 2020-05-20
32319218 In this report, we present a 77-year old patient with a heart transplant under relevant immunosuppressive therapy who was tested positive for SARS-CoV-2 after several days of dyspnoea, dry cough and light general symptoms. […] The patient received an antiviral therapy with hydroxychloroquine showing no further deterioration of the clinical state. 2020-04-22
32319424 Key messages include that supplemental oxygen is a first essential step for the treatment of severe COVID-19 patients with hypoxemia and should be a primary focus in resource-limited settings where capacity for invasive ventilation is limited. 2020-04-22
32319436 In the case of CoViD-19, we must rely on professionals: it is not the time for the anticipated treatment plan, for self-determination. 2020-04-24
32319443 The document, which aims to propose treatment decision-making criteria in the face of exceptional imbalances between health needs and available resources, has produced strong reactions, within the medical-scientific community, in the academic world, and in the media. 2020-04-24
32319444 The shortage of intensive care units (ICU) beds and ventilators for the treatment of patients with severe respiratory failure produced angst in the clinicians/intensivists who have to decide which patients admit to ICU and in which patients to implement palliative care. […] The patients not admitted to ICU due to clinical reasons and advanced stage diseases should receive a high quality palliative care, to obtain a good symptoms control (mainly dyspnea, anxiety and delirium) and to implement palliative sedation at the end of life. 2020-04-24
32319447 At the end of the bibliographic survey there is the current absence of evidence of efficacy in favor of vitamin D in the treatment of coronavirus infection in its various expressions. 2020-04-27
32319971 Due to the lack of current effective treatment and vaccine for COVID-19, screening, rapid diagnosis and isolation of the patients are essential (1, 2). 2020-04-22
32320003 Clinical outcomes during hospitalization, such as invasive mechanical ventilation, kidney replacement therapy, and death. […] During hospitalization, 373 patients (14.2%) (median age, 68 years [IQR, 56-78]; 33.5% female) were treated in the intensive care unit care, 320 (12.2%) received invasive mechanical ventilation, 81 (3.2%) were treated with kidney replacement therapy, and 553 (21%) died. 2020-05-01
32320066 All these indicate that more detailed criteria are needed for the treatment and the prevention of SARS-CoV-2 infected patients. 2020-04-29
32320359 Only 17.7% of respondents took prevention and 45.0% of skin injuries were treated. Innovation: This is the first cross-sectional survey to understand skin injuries in medical staff caused by PPE, which is expected to be a benchmark. Conclusion: The skin injuries among medical staff are serious, with insufficient prevention and treatment. 2020-05-01
32320375 Emerging infectious diseases by their nature, pose new challenges to the diagnostic-treatment-control nexus, and push our concepts of causality beyond the limits of the conventional Koch-Henle approach to aetiology. 2020-05-29
32320381 A poor understanding of the disease among health care workers (HCWs) may result in delayed treatment and result in the rapid spread of the infection. 2020-05-06
32320384 CP was also utilized for the treatment of one severe COVID-19 patient. 2020-05-06
32320477 As chloroquine (CHQ) is part of the Dutch Centre for Infectious Disease Control coronavirus disease 2019 (COVID-19) experimental treatment guideline, pediatric dosing guidelines are needed. 2020-05-21
32320478 The findings in animals are inconsistent with respect to an increase in ACE2 expression in response to treatment with ACEIs or ARBs. 2020-05-11
32320494 A survey was distributed to an expert panel of 37 pediatric dermatologists on the PDCRTF to assess expert opinion and current practice related to three primary domains of systemic therapy: initiation, continuation, and laboratory monitoring. […] In asymptomatic patients, continuing therapy was the most popular choice across all medications queried. […] The ultimate decision regarding initiation, continuation, and laboratory monitoring of immunosuppressive therapy during the pandemic requires careful deliberation, consideration of the little evidence available, and discussion with families. […] Consideration of an individual’s adherence to COVID-19 preventive measures, risk of exposure, and the potential severity if infected must be weighed against the dermatological disease, medication, and risks to the patient of tapering or discontinuing therapies. 2020-05-16
32320506 Proning has become a standard treatment in the management of patients with ARDS who have difficulty achieving adequate oxygen saturation. 2020-05-15
32320516 Here, we summarized the current known knowledge regarding epidemiological, pathogenesis, pathology, clinical features, comorbidities and treatment of COVID-19/ SARS-CoV-2 as reference for the prevention and control COVID-19. 2020-05-07
32320517 We performed a retrospective study in 2 French intensive care units (ICU) where CDU is performed as a standard of care. 2020-05-27
32320677 SARS-CoV-2 patient plasma inhibited HLA-DR expression, and this was partially restored by the IL-6 blocker Tocilizumab; off-label Tocilizumab treatment of patients was accompanied by increase in circulating lymphocytes. 2020-04-24
32320825 Currently, no specific medication is recommended to treat COVID-19 patients. […] In the current review, we summarize the existing state of knowledge about COVID-19, available medications, and treatment options. […] Favilavir is an antiviral drug that is approved in Japan for common influenza treatment and is now approved to treat symptoms of COVID-19 in China. […] Moreover, Chloroquine and hydroxychloroquine, drugs used to treat malaria and arthritis, respectively, were recommended by the National Health Commission of the People’s Republic of China for treatment of COVID-19. […] Presently, chloroquine and hydroxychloroquine are under investigation by the US Food and Drug Administration (FDA) as a treatment for COVID-19. 2020-05-26
32321116 Guidelines developed by experts can help all practitioners standardize their attitudes and improve the treatment of COVID-19. 2020-04-27
32321388 Nuanced considerations of five contingency planning strategies in response to COVID-19 are described, including COVID-19-specific precautions, visitor restrictions, physician workforce considerations, operational adjustments, and group therapy changes. 2020-04-23
32321524 To date, several drugs targeting RdRp enzymes are being employed for SARS-CoV-2 infection treatment. 2020-04-27
32321530 The CT image is used to assess the disease progress, whereas the continued two times of negative results from SARS-CoV-2 nucleic acid detection had been considered as a criterion for ending antiviral treatment. […] We compared the two COVID-19 cases with similar backgrounds and CT image repeated intervals under treatment. 2020-04-24
32321878 The recent clinical trial reports pertaining to the efficacy of chloroquine and hydroxychloroquine against COVID-19 albeit yet to be validated with larger clinical trials, have sparked much interest globally to evaluate whether this anti-malarial drug can be repurposed for the treatment of COVID-19. […] Based on our data obtained from an animal infection model of melioidosis (a disease caused by the bacteria Burkholderia pseudomallei), treatment with chloroquine can result in the phosphorylation and consequent inhibition of glycogen synthase kinase-3β (GSK3β). 2020-05-08
32321905 In late March and early April 2020, the antimalarial drug, chloroquine, has been approved as an emergency treatment for the coronavirus disease 2019 (COVID-19) in the United States and in Europe. […] Although infrequent, neuropsychiatric symptoms have been reported in patients who received chloroquine for the treatment of malaria or autoimmune diseases. […] Current pharmacovigilance study results did not suggest any potential link between the use of chloroquine and an increased risk of suicide, psychosis, confusion, and agitation, which would be informative during the emergency use of chloroquine for the treatment of COVID-19. 2020-05-22
32322046 The prevalence of malnutrition in elderly patients with COVID-19 was high, and nutritional support should be strengthened during treatment, especially for those with diabetes mellitus, low calf circumference, or low albumin. 2020-04-29
32322400 Although much is still unknown about SARS-CoV-2, the scientific research is moving at an unprecedented pace towards understanding the nature, effective control, prevention and treatment of SARS-CoV-2. […] Unfortunately, no effective treatment or therapeutic drug is available for the disease; only supportive treatment and classical intervention measures are available for confronting the SARS-CoV-2 pandemic. 2020-04-26
32322402 Covid-19 is so new that there is currently no specific vaccine or treatment. […] In vitro tests are also being conducted to assess the efficacy of chloroquine and hydroxychloroquine for the treatment of this epidemic, which is considered a pandemic by the WHO. 2020-04-26
32322478 No published treatment to date has been shown to adequately control the inflammation and respiratory symptoms associated with COVID-19, apart from oxygen therapy and assisted ventilation. […] We evaluated the effects of using high dose oral and/or IV glutathione in the treatment of 2 patients with dyspnea secondary to COVID-19 pneumonia. […] Oral and IV glutathione, glutathione precursors (N-acetyl-cysteine) and alpha lipoic acid may represent a novel treatment approach for blocking NFKappaB and addressing “cytokine storm syndrome” and respiratory distress in patients with COVID-19 pneumonia. 2020-04-25
32322758 Previous to the pandemic we commonly utilized total neoadjuvant therapy (TNT) with a strong preference for long course chemoradiation (LCCRT). […] In the setting of the ongoing pandemic we now mandate short course radiation therapy (SCRT). 2020-04-26
32322988 The general and special emergency management was optimized for the efficient treatment of COVID-19-positive patients and the staff were trained in the use of protective equipment. 2020-04-25
32323279 In this context, it was suspected that therapy with RAS blockers might promote transmission and complications of COVID-19 by upregulation of ACE2 expression. 2020-05-22
32323287 Against the background of the pandemic caused by infection with the SARS-CoV-2, the German Society for Pneumology and Respiratory Medicine (DGP e.V.), in cooperation with other associations, has designated a team of experts in order to answer the currently pressing questions about therapy strategies in dealing with COVID-19 patients suffering from acute respiratory insufficiency (ARI). […] Supply continuum for the treatment of ARIKey points have been highlighted as core statements and significant observations. […] This distinction can be taken into consideration in the differential instrumentation in the therapy of ARI.The assessment of the extent of ARI should be carried out by an arterial or capillary blood gas analysis under room air conditions and must include the calculation of the oxygen supply (measured from the variables of oxygen saturation, the Hb value, the corrected values of the Hüfner number and the cardiac output). […] If the specifications for protective equipment (eye protection, FFP2 or FFP-3 mask, gown) are adhered to, inhalation therapy, nasal high-flow (NHF) therapy, CPAP therapy or NIV can be carried out according to the current state of knowledge without increased risk of infection to the staff. […] In this situation, CPAP/NIV therapy can be administered under use of a mouth and nose mask or a respiratory helmet as therapy escalation, as long as the criteria for endotracheal intubation are not fulfilled.In acute hypoxemic respiratory insufficiency, NIV should be performed in an intensive care unit or in a comparable unit by personnel with appropriate expertise. 2020-04-23
32323460 Solid organ transplantation represents a field with a high demand on staff, intensive care units, and follow-up facilities. 2020-05-10
32323646 Hydroxychloroquine is mainly used as a therapy for autoimmune diseases. […] However, the efficacy and safety of CQ/HCQ for the treatment of COVID-19 remains to be defined. […] Indiscriminate promotion and widespread use of CQ/HCQ have led to extensive shortages, self-treatment, and fatal overdoses. 2020-04-23
32323974 Thus, this assay can achieve rapid and sensitive detection of anti-SARS-CoV-2 IgG in human serum and allow positive identification in suspicious cases; it can also be useful for monitoring the progression COVID-19 and evaluating patients’ response to treatment. 2020-05-21
32324101 The National Institute for Public Health of the Netherlands asked a group of Radiology and Vascular Medicine experts to provide guidance for the imaging workup and treatment of these important complications. 2020-04-23
32324209 COVID-19 was confirmed by real-time reverse transcription-polymerase chain reaction and epidemiologic, clinical, radiologic, laboratory, and drug therapy data were analyzed in all patients. 2020-04-30
32324352 This paper discusses the possible effects of comedication on COVID-19 and the current treatment options for this infection. […] Currently, chloroquine and remdesivir are possible treatment options. […] There is no sound evidence for either treatment. […] The treatment should be reconsidered in the event of side effects and when inferior medication for comorbidity must be prescribed because of possible interactions. […] Supportive care is at present the mainstay of the treatment. 2020-04-28
32324357 These challenges are the most critical in the field of intensive treatment and anesthesiology. […] One of the most important prerequisites of effective critical care treatment is preserving the involved healthcare workers from the infection, by providing them with detailed practical advices on the preventive measures and treatment strategies. 2020-04-27
32324359 In addition to the epidemiologic interventions aiming the deceleration of the outbreak, the early identification and the correct hospital treatment remain key issues since these may influence mortality. 2020-04-27
32324361 There is currently no proven effective therapy for COVID-19. […] Here we discuss the drugs most investigated for the treatment of the disease. […] However, due to the severe healthcare effects of the pandemic and the potentially fatal outcome of COVID-19 patients treated in the intensive care units, their off-label use should none-the-less be considered. 2020-04-27
32324364 The purpose of this summary is to present the practical aspects of anesthetic and perioperative care for patients requiring surgical treatment. 2020-04-27
32324365 The best treatment is early endotracheal intubation and invasive mechanical ventilation. 2020-05-04
32324366 In recent years, CytoSorb-haemoperfusion to remove cytokines has shown promising results in the treatment of septic shock. 2020-04-27
32324533 In animal experiments, estrogen treatment silences the inflammatory reactions and decreases virus titers leading to improved survival rate; it seems to be an ideal prevention and therapy against COVID-19. […] We should overcome the widespread reluctance to estrogen therapy as we have a unique estrogen formula; conjugated estrogens, or conjugated equine estrogens available under the brand name of Premarin deriving from natural sources. 2020-04-28
32324898 Together, the incidence of ADRs was significantly high during the treatment period. […] Moreover, the active monitoring of the CHPS system reflected ADRs during COVID-19 treatment in the real world, which provided reference for safe medication in the clinic. 2020-05-26
32324951 There is no effective vaccine or approved drug treatment against COVID-19 and other pathogenic coronaviruses. 2020-05-07
32324985 In this article, besides providing a summary of literature, we would also like to make practical recommendations which may increase the safety of healthcare providers participating in the treatment or pathological duties with COVID-19 suspected, probable and confirmed cases. 2020-04-27
32325096 There may be a risk of COVID-19 transmission to rescuers delivering treatment for cardiac arrest. […] The aim of this review was to identify the potential risk of transmission associated with key interventions (chest compressions, defibrillation, cardiopulmonary resuscitation) to inform international treatment recommendations. […] Data from manikin studies indicates that donning of personal protective equipment delays treatment delivery. 2020-05-20
32325124 This article examines three aspects of antivirals, such as hydroxychloroquine, chloroquine, and remdesvir, as they might relate to the treatment of a viral infection such as COVID-19: (i) the use of vaporization for the delivery of antivirals, with the bulk constituents having mild antiviral efficacy; (ii) the application of a marine natural product extract as opposed to a single molecule as an antiviral agent; and (iii) a counter intuitive approach to formulation that is, in part, based on delivering multiple species that fall into three categories: building blocks for the virus to accelerate replication; an energy source for the infected cell to boost its immune response; and the species that antagonize or provide toxicity to the virus. 2020-04-28
32325167 Hospital palliative care is an essential part of the COVID-19 response but data are lacking. […] We identified symptom burden, management, response to treatment, and outcomes for a case series of 101 inpatients with confirmed COVID-19 referred to hospital palliative care. […] Patients spent a median [IQR] of 2 [1-4] days under the palliative care team, who made 3 [2-5] contacts across patient, family, and clinicians. […] At March 30, 2020, 75 patients had died; 13 been discharged back to team, home, or hospice; and 13 continued to receive inpatient palliative care. […] Palliative care is an essential component to the COVID-19 response, and teams must rapidly adapt with new ways of working. […] An international minimum data set for palliative care would accelerate finding answers to new questions as the COVID-19 pandemic develops. 2020-05-11
32325252 Lack of targeted therapy continues to be a problem. 2020-05-31
32325767 While novel vaccines and drugs that target SARS-CoV-2 are under development, this review provides information on therapeutics which are under clinical trials or are proposed to antagonize SARS-CoV-2. 2020-04-27
32325888 A large number of dentists (90%) were aware of recent changes in the treatment protocols. […] However, execution of amended treatment protocol was recorded as 61%. […] A number of dental practices have either modified their services according to the recommended guidelines to emergency treatment only or closed down practices for an uncertain period. 2020-04-29
32326343 While great resources are understandably being dedicated to treatment and diagnosis, more efforts could be dedicated to limit the virus spread. 2020-05-23
32326426 If chlorhexidine, a usual component of mouth rinse, is not efficient to kill SARS-CoV-2, the use of a mouth rinses and/or with local nasal applications that contain β-cyclodextrins combined with flavonoids agents, such as Citrox, could provide valuable adjunctive treatment to reduce the viral load of saliva and nasopharyngeal microbiota, including potential SARS-CoV-2 carriage. 2020-05-23
32326509 Technical and logistical issues arise when establishing such a non-standardized treatment into clinical practice with safety and proper governance. 2020-04-24
32326602 This constant transmission of a novel coronavirus and its ability to spread from human to human have prompted scientists to develop new approaches for treatment of COVID-19. […] Here, we systemically discuss the pharmacological therapeutics targeting RNA-dependent RNA polymerase (RdRp), proteinase and S protein for treatment of SARS-CoV-2 infection. […] In addition, we will discuss the viability and challenges in targeting RdRp and proteinase, and application of natural product quinoline and its analog chloroquine for treatment of coronavirus infection. 2020-05-23
32326671 This article aims to propose a treatment algorithm for the management of traumatic spine fracture during the COVID-19 pandemic. 2020-04-24
32327245 The combinations with GGOs could be useful in the identification and differential diagnosis of COVID-19, alerting clinicians to isolate patients for prompt treatment and repeat RT-PCR tests until the end of incubation. 2020-04-27
32327293 With the emergence of the COVID-19 virus and considering the lack of effective pharmaceutical treatment for it, there is an urgent need to identify safe and effective drugs or potential adjuvant therapy in this regard. 2020-04-26
32327383 Ultrasound, although not used in the diagnosis of COVID-19 may be utilised by practitioners at the point of care (POC) or on the intensive care units (ITUs) where rapid assessment of the lung condition may be required. 2020-04-27
32327397 Risks of treatment include QT segment prolongation, Torsades de Pointes (TdP), and death. 2020-04-27
32327490 The recommendations focus on administration of as much care as possible at home to keep people with epilepsy out of health care facilities, where they are likely to encounter COVID-19 (including strategies for rescue therapy), as well as minimization of risk of seizure exacerbation through adherence, and through ensuring a regular supply of medication. 2020-04-24
32327746 To mark the tenth anniversary of anti-IL-6 receptor therapy worldwide, we discuss the history of research into IL-6 biology and the development of therapies that target IL-6 signalling, including the successes and challenges and with an emphasis on rheumatic diseases. 2020-05-29
32327870 However, there is very scarce information on the management of thrombotic risk, coagulation disorders, and anticoagulant therapy. […] This article by the Working Group on Cardiovascular Thrombosis of the Spanish Society of Cardiology aims to summarize the available information and to provide a practical approach to the management of antithrombotic therapy. 2020-04-24
32327904 Many of the medications used for treatment of COVID-19 can also be associated with GI symptoms or liver injury and can be included in the differential diagnosis in these patients. 2020-04-27
32328206 This is particularly so for peritoneal neoplastic diseases, for which curative treatment mobilizes substantial personnel, operating room and intensive care resources. […] It is desirable to prioritize disease conditions for which cytoreduction surgery with or without associated hyperthermic intraoperative peritoneal chemotherapy (HIPEC) is the gold-standard treatment, and for which systemic chemotherapy cannot be a temporary or long-term alternative: pseudomyxoma peritonei, resectable malignant peritoneal mesotheliomas, peritoneal metastases of colorectal origin if they are resectable and unresponsive to systemic chemotherapy after up to 12 courses, first-line ovarian carcinomatosis if resectable or in interval surgery after at most six courses of systemic chemotherapy. 2020-04-24
32328367 This review will introduce a general overview of coronavirus and describe the clinical features, evaluation, and treatment of COVID-19 patients. 2020-04-27
32328369 Observational studies and therapeutic trials pertaining to COVID-19 are essential for assessing pathogenic characteristics and developing novel treatment options. 2020-04-27
32328595 The protocol is designed for a hospital setting and includes considerations related to dental treatment in both healthy subjects and those suspected or diagnosed with COVID-19. 2020-04-27
32328757 Other important measures include triaging of patients to identify those at the greatest risk of irreversible vision loss and prioritization of treatment visits over monitoring visits where possible. […] In order to limit patient exposure, ophthalmologists should refrain from using treatment regimens that require frequent monitoring. 2020-05-21
32328850 When it comes to treatment, specific drugs for COVID-19 have not been found at present, and taking old drugs for new use in treating COVID-19 has become an emergency method for the pandemic. 2020-05-01
32329046 This evidence, together with the experience of the authors in the management of patients with multiple sclerosis during the pandemic, will make it possible to offer some proposals for the treatment and follow-up of patients in this epidemiological context. […] After the literature search and our experience in the management of patients, a number of proposals for treatment are established for each drug, which must necessarily be individualised for each patient, since, in these exceptional circumstances, their peculiarities can affect the prognosis. 2020-04-28
32329231 A series of patients managed in the Cremona Thrombosis Center were admitted at Cremona Hospital for SARS-CoV-2 and started antiviral drugs without stopping DOAC therapy. […] Plasma samples for DOAC measurement were collected 2to 4 days after starting antiviral treatment, at 12 hours from the last dose intake in patients on dabigatran and apixaban, and at 24 hours in those on rivaroxaban and edoxaban. […] Of the 1039 patients hospitalized between February 22 and March 15, 2020 with COVID-19 pneumonia and candidates for antiviral therapy, 32 were on treatment with a DOAC. 2020-05-06
32329246 Prophylaxis treatment of COVID-19 patients with low molecular weight heparin (LMWH) is important to limit coagulopathy. […] In this review, we discuss the repurposing of fibrinolytic drugs, namely tissue-type plasminogen activator (tPA), to treat COVID-19 associated ARDS. tPA is an approved intravenous thrombolytic treatment, and the nebulizer form has been shown to be effective in plastic bronchitis and is currently in Phase II clinical trial. 2020-04-24
32329275 All articles were categorized into epidemiology, clinical diagnosis and treatment, basic research, pregnant women and children, mental health, epidemic prevention & control, and others. 2020-04-27
32329276 In this review we introduce these research works related to spike proteins, hoping it will provide reasonable ideas for the control of the current pandemic, as well as for the diagnosis and treatment of COVID-19. 2020-04-27
32329404 Early reports of potential treatment for coronavirus disease (COVID-19) have raised concerns related to pharmaceutical distribution. 2020-04-24
32329419 The lack of availability of approved treatment for this disease calls forth the scientific community to find novel compounds with the ability to treat it. 2020-05-14
32329520 No specific therapies/vaccines are yet available for the treatment of COVID-19. 2020-05-16
32329563 Further studies are needed to better investigate the causes of liver injury in patients with COVID-19 disease and the effect of treatment for COVID-19 on the liver. 2020-05-31
32329659 Concerns about the prevention and management of COVID-19 are on the rise, as it is crucial in contagious epidemics that travel and transfer of the patients be minimal for diagnosis, treatment, and follow-ups. 2020-04-24
32329877 Additionally, we have discussed various therapeutic strategies for COVID-19 under different categories, like the possible treatment plans with drug (antiviral drugs and anti-cytokines) therapy for disease prevention. […] Collectively, the review provides an overview of the SARS-CoV-2 infection outbreak along with the recent advancements and strategies for diagnosis and therapy of COVID-19. 2020-04-30
32329879 However, the current treatment options include hydroxychloroquine, tocilizumab, remdesivir, lopinavir-ritonavir (Kaletra®), and nitazoxanide. 2020-04-30
32329881 In this case series, we aimed to report preliminary data obtained with anti-complement C5 therapy with eculizumab in COVID-19 patients admitted to intensive care unit (ICU) of ASL Napoli 2 Nord. […] Patients were also treated with anticoagulant therapy with Enoxaparin 4000 IU/day via subcutaneous injection, antiviral therapy with Lopinavir 800 mg/day + Ritonavir 200 mg/day, hydroxychloroquine 400 mg/day, ceftriaxone 2 g/day IV, vitamine C 6 g/day for 4 days, and were on Non-Invasive Ventilation (NIV). […] All patients successfully recovered after treatment with eculizumab. […] Eculizumab has the potential to be a key player in treatment of severe cases of COVID-19. […] Our results support eculizumab use as an off-label treatment of COVID-19, pending confirmation from the ongoing SOLID-C19 trial. 2020-04-29
32329920 We highlight the importance of collaborative treatment decisions between the patient, family, and health-care provider, considering any geographic or institution-specific policies and precautions for COVID-19. 2020-05-05
32329921 We emphasize the importance of collaborative treatment decisions between the patient, family, and healthcare provider, considering any geographic- or institution-specific policies and precautions for COVID-19. 2020-05-06
32329924 In the context of COVID-19, cancer survivors represent a particularly vulnerable population that may be “doubly hit” by both costs of cancer treatment and financial strain imposed by the pandemic. 2020-05-29
32329930 Allergen-specific immunotherapy (AIT) is one of the most important treatment options for IgE-mediated allergies and is based on immunological effects on the diseased patient. 2020-04-24
32329953 Patients with oral cancer are susceptible often immunosuppressed due to the disease and/or the treatment received. […] Stage IV patients with oral cancer who did not receive treatment had progression of disease and an increased mortality rate compared to patients who receive treatment but did not contract COVID-19. […] The patients who received treatment and got affected with COVID-19 had a far worse impact and higher mortality rate than all other groups. […] Isolation and deferring treatment for stage IV patients with oral cancer, so as to avoid hospital visits and contraction of COVID-19, is an advisable strategy based on this model. 2020-05-29
32329958 Multidisciplinary conferences (MDC) are an important component of head and neck oncologic care including diagnosis, treatment, and survivorship. 2020-05-29
32330073 While of high utility in the management of HAPE and acute mountain sickness, systemically delivered pulmonary vasodilators and acetazolamide should not be used in the treatment of COVID-19, as they carry the risk of multiple adverse consequences including worsened ventilation-perfusion matching, impaired carbon dioxide transport, systemic hypotension and increased work of breathing. 2020-04-24
32330124 With the current rapid spread of COVID-19, global health systems are increasingly overburdened by the sheer number of people that need diagnosis, isolation and treatment. […] Here, we summarise community-driven approaches based on Free and Open Source scientific and medical Hardware (FOSH) as well as personal protective equipment (PPE) currently being developed and deployed to support the global response for COVID-19 prevention, patient treatment and diagnostics. 2020-04-29
32330208 Such major viral outbreaks demand early elucidation of taxonomic classification and origin of the virus genomic sequence, for strategic planning, containment, and treatment. 2020-04-29
32330277 There is no specific antiviral therapy recommended for coronavirus disease 2019 (COVID-19). […] Data presented here refer primarily to safety and lethality outcomes during treatment on day 13. 2020-04-29
32330288 With the developing COVID-19 pandemic, patients with inherited anaemias require specific advice regarding isolation and changes to usual treatment schedules. […] Cascading of accurate information for clinicians and patients is paramount to preventing adverse outcomes, such as patients who are at increased risk of fulminant bacterial infection due to their condition or its treatment erroneously self-isolating if their fever is mistakenly attributed to a viral cause, delaying potentially life-saving antibiotic therapy. 2020-05-19
32330293 This patient had recovered from the pneumonia after treatment. 2020-04-24
32330303 A combination of nucleic acid and IgM-IgG testing is a more sensitive and accurate approach for diagnosis and early treatment of COVID-19. 2020-05-08
32330313 The puerpera returned to normal after the operation and two times of throat swab COVID-19 nucleic acid test were all negative after antiviral therapy. 2020-04-30
32330521 Presently, no approved treatment or prophylaxis is available for COVID-19. 2020-05-08
32330817 Bedside clinicians abstracted daily patient data on history, treatment, and short-term course. […] We describe management and a proposed severity scale for treatment used in this hospital. 44 patients were enrolled; with incomplete information on 11. […] Patients also received lopinivir/ritonavir (82%), hydroxychloroquine (79%), and tocilizumab (12%) according to this treatment algorithm. 2020-05-19
32330858 The COVID-19 pandemic demands reassessment of head and neck oncology treatment paradigms. […] Additionally, novel, COVID-19-specific multilevel risks to HNC patients, HCWs and institutions, and society include: use of immunosuppressive therapy, nosocomial COVID-19 transmission, institutional COVID-19 outbreaks, and, at some locations, societal resource deficiencies requiring health care rationing. […] Until these risks are managed, we temporarily favor nonsurgical therapy over surgery for most mucosal squamous cell carcinomas, wherein surgery and nonsurgical therapy are both first-line options. 2020-05-20
32330970 This case report describes successful treatment of preterm labor during acute COVID-19 infection. […] Standard treatment for preterm labor may allow patients with acute COVID-19 infection to recover without the need for preterm delivery. […] · Standard treatment for preterm labor such as intravenous magnesium sulfate, antepartum steroid therapy and antibiotic prophylaxis for group B streptococcus infection were effective in this patient.. 2020-04-24
32331217 Here, we discuss the rationale and some important considerations about timing, criteria, and monitoring requirements for patients with COVID-19 respiratory failure requiring a CPAP treatment. 2020-05-23
32331255 In this context, the present review article provides a cumulative account of the recent information regarding the viral characteristics, potential therapeutic targets, treatment options, and prospective research questions. 2020-05-29
32331343 In addition to this first aspect, the recent evidence of an increased frequency of venous thromboembolism in patients with COVID-19 (a clinical element associated with a worse prognosis) calls the attention on the safety of treatment with testosterone, in particular in hypogonadal men with greater genetic predisposition. 2020-04-28
32332319 We illustrate the symptoms initiation, the laboratory test results, the imaging examination, and the treatment strategy in the duration of COVID-19 with a timeline chart. 2020-05-06
32332765 As these fusion proteins exhibit cross-reactivity against coronaviruses, they have potential applications in the diagnosis, prophylaxis, and treatment of SARS-CoV-2. 2020-04-28
32333185 We focus on multiple levels of intervention including intrapersonal, interpersonal, community, and social factors, each of which provide a reference point for understanding and elaborating on social/behavioral lessons learned from HIV prevention and treatment research. […] The investments in HIV prevention and treatment research far outweigh any infectious disease in the history of public health, that is, until now with the emergence of COVID-19. 2020-05-26
32333196 As we know more about the clinical and laboratory features of COVID-19, which is now accepted as a pandemic, many questions have been raised about how to manage and monitor the treatment of cancer patients. […] This article was written for a hypothetical approach in cancer patients diagnosed with COVID-19 in order to be an idea of collecting data for treatment with anti-cancer drugs that cause lymphopenia. 2020-04-28
32333248 In the early February, 2020, we called up an experts’ committee with more than 30 Chinese experts from 11 national medical academic organizations to formulate the first edition of consensus statement on diagnosis, treatment and prevention of coronavirus disease 2019 (COVID-19) in children, which has been published in this journal. […] With accumulated experiences in the diagnosis and treatment of COVID-19 in children, we have updated the consensus statement and released the second edition recently. […] The current version in English is a condensed version of the second edition of consensus statement on diagnosis, treatment and prevention of COVID-19 in children. […] This version of experts consensus will be valuable for better prevention, diagnosis and treatment of COVID-19 in children worldwide. 2020-05-01
32333293 As hospital resources and staff become more limited during the COVID-19 pandemic, it becomes critically important to define which BC patients require more urgent care and which patients can wait for treatment until the pandemic is over. […] Additionally, we provide treatment recommendations for each of these patient scenarios. […] Priority A patients have conditions that are immediately life threatening or symptomatic requiring urgent treatment. […] Priority B patients have conditions that do not require immediate treatment but should start treatment before the pandemic is over. […] Physicians should use these recommendations to prioritize care for their BC patients and adapt treatment recommendations to the local context at their hospital. 2020-05-18
32333494 Nevertheless, genetic factors in different ethnic groups often contribute to disease severity and treatment response. […] Finally, if a link to genetic variations in the androgen receptor and COVID-19 disease severity can be established, it would suggest new treatment options. 2020-04-25
32333552 Movement disorder (Parkinson’s disease, essential tremor, dystonia), neuropsychiatric disorder (obsessive compulsive disorder, Tourette syndrome, depression), and epilepsy patients can develop varying degrees of symptom worsening from interruption of therapy due to neurostimulator battery reaching end of life, device malfunction or infection. […] Similarly, patients with generalized dystonia can develop status dystonicus, patients with obsessive compulsive disorder can become suicidal, and epilepsy patients can experience potentially life-threatening worsening of seizures as a result of therapy cessation. […] The decision for replacement of the implantable pulse generator to prevent interruption of DBS therapy should be made on a case-by-case basis taking into consideration battery status and a patient’s tolerance to potential therapy disruption. 2020-04-25
32333601 We further hypothesized that their expression could be affected by inflammation or medication usage. […] Patients with IBD do not have higher expression during inflammation; medical therapy is associated with lower levels of ACE2. 2020-05-14
32333823 Corticosteroids and non-steroid immunomodulatory agents are the mainstays of treatment. […] Treatment can be challenging particularly in pemphigus, mucous membrane pemphigoid, and epidermolysis bullosa acquisita which may require more intense immunosuppressive approaches. 2020-04-25
32333929 Major issues for patients with ILD will include restricted access to key components of the diagnostic process, new uncertainties in the use of common ILD pharmacotherapies, limited ability to monitor both disease severity and the presence of medication adverse effects, and significantly curtailed research activities. 2020-05-10
32334062 There is currently no specific treatment available for patients with COVID-19 infection. […] Numerous potential therapies, including supportive intervention, immunomodulatory agents, antiviral therapy, and convalescent plasma transfusion, have been tentatively applied in clinical settings. 2020-04-29
32334158 The present day is dominated by studies on determining the factors that affect, taking preventive actions, and trying to find an effective treatment on top priority. 2020-05-19
32334163 Unani is a traditional system of medicine developed during the middle ages, which employs natural drugs of herbal, animal and mineral origin for treatment. 2020-05-19
32334182 To improve this, public health officials should provide a timely, clear rationale for quarantine and information about protocols; emphasise social norms to encourage this altruistic behaviour; increase the perceived benefit that engaging in quarantine will have on public health; and ensure that sufficient supplies of food, medication and other essentials are provided. 2020-05-29
32334502 To date, no definitive treatment orvaccine application exists for COVID-19. […] Although new investigations seek to repurpose existingantiviral treatments for COVID-19, innovative treatment strategies not normally considered tohave antiviral capabilities may be critical to address this global concern. […] One such avenue that mayprove to be exceedingly fruitful and offer exciting potential as new antiviral therapy involves themechanistic target of rapamycin (mTOR) and its associated pathways of mTOR Complex 1(mTORC1), mTOR Complex 2 (mTORC2), and AMP activated protein kinase (AMPK). […] Yet, important considerationsfor the development of safe and effective antiviral therapy with mTOR pathways exist. 2020-05-04
32334535 We here discuss this concern in relation to headache treatment and conclude that, based on current evidence, there is no reason to abandon treatment of headache patients with RAS inhibitors or ibuprofen. 2020-04-28
32334800 As the global incidence of COVID-19 disease is increasing dramatically, health systems worldwide started to suffer in terms of its capability to manage affected people and the ability to provide standard treatment for critically ill patients in a safe environment. 2020-04-29
32334905 In the radiotherapy department of Mulhouse hospital (France), we pointed five points out: protection of medical and paramedical staff, protection of patients undergoing treatment, detection of patients suspected of being infected by SARS-CoV-2 and their management, reorganization of the patient circuit and measures regarding the quality management. 2020-04-28
32335097 It has been hypothesized that DPP4 inhibition, a therapy currently available for type 2 diabetes, might represent a target for decreasing the risk of the acute respiratory complications of the COVID-19 infection but (1) lack of demonstration of SARS-CoV2 binding to DPP4 (2) possible protective role of sDPP4 in Middle East respiratory Syndrome (MERS-CoV) (3) demonstrated inhibition and downregulation of DPP4 by HIV1 and MERS-CoV and (4) not exclusive role of the receptor binding in tropism of the Coronavirus family, support that DPP4 inhibition at present doesn’t represent a plausible approach to mitigate COVID-19. 2020-05-11
32335281 This brief article discusses the therapeutic potential of glycyrrhizin for the treatment of COVID-19 from the perspective of its pharmacological action, including binding angiotensin-converting enzyme II (ACE2), downregulating proinflammatory cytokines, inhibiting the accumulation of intracellular reactive oxygen species (ROS), inhibiting thrombin, inhibiting the hyperproduction of airway exudates, and inducing endogenous interferon. 2020-05-03
32335367 We further explain the therapeutic approaches that can be taken in the treatment and prevention of this viral infection. 2020-05-27
32335406 These predictors would provide a new perspective on early identification of patients with prolonged viral shedding and facilitate optimal isolation protocols and treatment strategies. 2020-05-19
32335426 Early detection, isolation, diagnosis, and treatment are the most effective means of prevention and control. […] The current gold standard for the diagnosis of COVID-19 is the detection of coronavirus nucleic acids, but imaging has an important role in the detection of lung lesions, stratification, evaluation of treatment strategies, and differentiation of mixed infections. 2020-05-15
32335561 Through PubMed, we explored the relevant articles published on treatment of COVID-19 and on trials ongoing up to April 15, 2020. 2020-04-28
32335585 There is no proven antiviral agent against SARS-CoV-2 so the treatment for COVID-19 is symptomatic, aiming for the management of the symptoms and prevention of the complications. […] Numerous antiviral compounds used to treat other infections are being clinically researched to find possible treatment. 2020-04-28
32335900 Treatment times and wearer comfort were determined and compared. […] All anaesthetists accomplished the treatment objectives of all study arms without adverse events. 2020-05-29
32336069 Early recognition and treatment is crucial in these cases. […] Thus, it is important to know typical COVID‑19 symptoms, possible clinical manifestations, complications, and recommended treatment. 2020-04-30
32336150 Recommendations should be adapted to the local environment and will continue to evolve as more data become available, the shortage of testing and PPE is resolved, and a vaccine and therapeutics for COVID-19 are developed. 2020-05-25
32336317 This pandemic situation has forced scientists to rework strategies to combat infectious diseases through drugs, treatment, and control measures. […] COVID-19 treatment requires both limiting viral multiplication and neutralizing tissue damage induced by an inappropriate immune reaction. […] Currently, various diagnostic kits to test for COVID-19 are available, and repurposing therapeutics for COVID-19 has shown to be clinically effective. […] As the global demand for diagnostics and therapeutics continues to rise, it is essential to rapidly develop various algorithms to successfully identify and contain the virus. 2020-04-29
32336563 The document provides clinical recommendations for the noninvasive respiratory support (noninvasive ventilation, high flow oxygen therapy with nasal cannula) in any patient with suspected or confirmed presentation of COVID-19 with acute respiratory failure. 2020-04-27
32336564 These findings will facilitate the decision making regarding the patient management, both when deciding the place of admission of the patient and the type of treatment to be prescribed. 2020-04-29
32336586 The COVID-19 pandemic has been particularly challenging due to a lack of established therapies and treatment guidelines. […] Several antivirals, antimalarials, and biologics are being considered for treatment at this time. […] The purpose of this literature review is to synthesize the available information regarding treatment options for COVID-19 and serve as a resource for health care professionals. […] This narrative review was conducted to summarize the effectiveness of current therapy options for COVID-19 and address the controversial use of non-steroidal anti-inflammatory drugs (NSAIDs), angiotensin converting enzyme (ACE) inhibitors, and angiotensin receptor blockers (ARBs). […] PubMed and SCOPUS were queried using a combination of the keywords “COVID 19,” “SARS-CoV-2,” and “treatment.” All types of studies were evaluated including systematic reviews, case-studies, and clinical guidelines. […] Current guidelines recommend combination treatment with hydroxychloroquine/azithromycin or chloroquine, if hydroxychloroquine is unavailable, in patients with moderate disease, although these recommendations are based on limited evidence. […] Until the results of these trials become available, we must use the best available evidence for the prevention and treatment of COVID-19. 2020-05-03
32336594 Since containment of the outbreak may have partially failed due to asymptomatic transmission, it is imperative to accelerate the development of rapid point-of-care diagnostic tests, vaccines, and therapeutics for the COVID-19 epidemic. 2020-04-30
32336673 Pharmacists have successfully completed the tasks of purchase, storage, and free distribution of drugs worth ¥1.03 million (approximately $146,000), reviewed about 20,000 electronic orders, provided one-on-one online medication consultation for 484 patients, and held 5 lectures on rational drug use knowledge, which could help reduce irrational drug use and minimize the risk involved. […] They not only ensured the timely supply of the drugs but also reduced the incidence of drug-induced risks through medication review and guidance, thereby improving patient compliance and helping the patients rebuild their confidence in overcoming the disease. 2020-04-30
32336723 Currently, no treatment for SARS-CoV-2 are approved because of lack of evidence, but a number of clinical trials are in process and we are expecting fruitful results very soon. […] This review focuses on various approaches of treatment and few of the most recent clinical trials carried out in this field. 2020-05-08
32336927 This review article summarizes the developing situation surrounding the SARS-CoV-2 pandemic with respect to its epidemiology, unique genomic structure, possible origins, transmission, pathogenesis, comparison with other deadly species of Coronaviruses (CoV) and emerging treatment strategies built on informed literature. 2020-05-22
32336959 Due to lack of data on treatment strategies specific to this subset of patients, currently available evidence on management of the critically ill needs to be extrapolated and customized to their clinical needs. 2020-05-06
32337113 In this study, we will provide a brief review of viral origin, identification, symptoms, transmission, diagnosis, and potential treatment strategies for the newly identified SARS-CoV-2 strain. 2020-04-30
32337139 Recent findings of an open-label study that investigated the use of hydroxychloroquine and azithromycin in COVID-19 patients in Marseille, France, has garnered some optimism in scientific quarters and the general public alike in terms of finding a treatment regimen to control the rampant rise of COVID-19. […] We will discuss the potential off-label therapy and studies as it pertains to COVID-19. 2020-04-30
32337143 Since there is no specific therapeutic intervention nor a vaccine available against the virus, supportive management and treatment with non-specific therapeutic agents (repurposed drugs) may provide relief to the patients. 2020-04-30
32337148 We need more research in Covid-19 patients with cardiovascular involvement for early diagnosis, prevention of exposure to health care workers and effective treatment. 2020-04-30
32337192 Here, we introduce a modified treatment method for COVID-19-associated pneumonia. 2020-04-30
32337201 Careful acquisition of an epidemiological history is necessary to make a correct diagnosis and strategize a treatment plan. 2020-04-30
32337328 This work shows a patent database for Coronaviruses that provides an overview of the patenting activity and trends in focused antiviral therapy with the use of triazole based compounds, glycoprotein, and protease inhibitors as possible treatment. […] The patent data was obtained from Orbit Intelligence Software using a patent family structure to get a big database that could be used for built patent landscape report (PLR), market analysis, technical and competitive intelligence, and monitoring and survey of a new ideas for the treatment of coronavirus diseases. 2020-04-30
32337386 In light of the COVID-19 pandemic, hospitals and proton eye therapy facilities must analyze several factors to ensure appropriate treatment protocols for patients and provider teams. […] Practice considerations to limit COVID-19 transmission in the proton ocular treatment setting for UM are necessary. […] The Particle Therapy Co-Operative Group (PTCOG) is the largest international community of particle/proton therapy providers. 2020-04-30
32337664 Tocilizumab, which is the IL-6 receptor antagonist, has been approved by the US FDA for the treatment of cytokine release syndrome (CRS), is expected to treat cytokine storm caused by COVID-19 and is now in clinical trials. […] In this paper, we will elaborate the role of cytokine storm in COVID-19, the mechanism of tocilizumab on cytokine storm and the key points of pharmaceutical care based on the actual clinical application for COVID-19 in our hospital, the latest research reports, clinical trial progress of tocilizumab, drug instruction from the US FDA, and “Diagnosis and Treatment Plan of Novel Coronavirus Pneumonia (seventh trial edition)” in China, so as to provide reference for the treatment of COVID-19. 2020-05-28
32337769 Successful treatment of viral infections has proven to be huge challenge for modern medicine with the most effective approach being prior vaccination. […] Therefore, any treatment which can decrease the severe symptoms due to lung damage may help attenuate mortality rates. […] Noscapine, a medication used for the treatment of cough, has been shown to inhibit bradykinin enhanced cough response in man. 2020-04-27
32337790 The clinical course was complicated by extreme overexposure to the mammalian target of rapamycin inhibitor everolimus, following coadministration of chloroquine and lopinavir/ritonavir therapy. […] The case is illustrative for dilemmas that transplant professionals may face in the absence of evidence-based COVID-19 therapy and concurrent pressure for exploration of experimental pharmacological treatment options. […] However, the risk-benefit balance of experimental or off-label therapy may be weighed differently in organ transplant recipients than in otherwise healthy COVID-19 patients, owing to their immunocompromised status and potential drug interactions with immunosuppressive therapy. […] With this case report, we aimed to achieve increased awareness and improved management of drug-drug interactions associated with the various treatment options for COVID-19 in renal transplant patients. 2020-05-13
32338155 Anti-malarial medicine chloroquine (CQ) and particularly its chemical analogue hydroxychloroquine (HCQ) have been recommended as promising candidate therapeutics that are now under either compassionate off-label use or clinical trials for the treatment of COVID-19 patients. […] Given the fact that for decades HCQ has been approved as an immunomodulatory drug for the long term treatment of chronic rheumatic diseases, as experienced rheumatologists, we would like to share our thoughts in this regard and trigger a brainstorm among clinical care providers for exchanging their diverse opinions on this urgent topic. 2020-05-05
32338164 New treatment against SARS-CoV-2 now is a must. […] The compounds 2 and 3 may tightly bind to the SARS-CoV-2 RdRp and so may be successful in the treatment of COVID-19. 2020-05-16
32338224 In this framework, Gurwitz [40] proposed to use AT1R blockers, such as losartan, as a potential treatment of COVID-19 infection. […] In fact, losartan as well as olmesartan, used for treating hypertension in patients, were able to increase ACE2 expression after 28 days treatment of rats with myocardial infarction [41]. […] Then, Gurwitz suggests to evaluate severity of symptoms in COVID-19 infected patients under previous chronic treatment with AT1R blockers in comparison to COVID-19 infected patients who did not take AT1R blockers [40]. 2020-04-27
32338298 At present, HNC patients may be anxious and due to logistical issues, may not be adequately prepared for their treatment. […] To ensure that patients have a thorough understanding of their treatment and expected outcome during the current COVID-19 crisis there may be merit in the use of the HaNC-AD PCI. 2020-05-08
32338708 There are many pharmacologic therapies that are being used or considered for treatment of COVID-19. […] Develop evidence-based rapid guidelines intended to support patients, clinicians and other health-care professionals in their decisions about treatment and management of patients with COVID-19. […] The IDSA guideline panel agreed on 7 treatment recommendations and provided narrative summaries of other treatments undergoing evaluations. 2020-05-06
32338790 The 2019 novel coronavirus (COVID-19) pandemic has created significant challenges to the delivery of care for patients with advanced head and neck cancer requiring multimodality therapy. 2020-05-29
32338809 In a palliative care clinic, this apprehension gets exemplified, as these patients have limited life expectancy. 2020-05-29
32339025 As directors of two major academic cardiac catheterization laboratories in the city, we both have had to operationalize logistical planning of physician and staff redeployments as well as modification of our respective hospital units including conversion of large portions of the catheterization laboratory into COVID-19 intensive care units in order to deal with the surge of COVID-19 patients within the hospital. 2020-04-27
32339235 During the ongoing COVID-19 pandemic, contact with the healthcare system for cancer treatment can increase risk of infection and associated mortality. […] Treatment recommendations must consider this risk for elderly and vulnerable cancer patients. […] We extracted individual patient-level data (IPLD) for 1,321 patients from Kaplan-Meier curves from five randomized trials on treatment of elderly GBM patients including available subanalyses based on MGMT methylation status. […] Our simulations reveal how COVID-19-associated risks affect survival under different treatment regimens. […] In patients with methylated MGMT receiving single modality treatment, TMZ-alone treatment approaches may be an option in settings with high COVID-19-associated risk. […] Our quantitative framework can serve as a model for assessing COVID-19 risk associated with treatment across neuro-oncology. 2020-05-06
32339248 There is no specific antiviral therapy recommended for coronavirus disease 2019 (COVID-19). […] Data presented here refer primarily to safety and lethality outcomes during treatment on day 13. 2020-04-30
32339250 This approach will provide much needed insight into the underlying molecular dynamics of COVID-19 for the development of novel treatment and prevention strategies. 2020-04-27
32339260 We discuss how preventative and control measures implemented during the COVID-19 crisis could affect the prevalence of anaemia, and highlight issues regarding the diagnosis and treatment of anaemia in patients requiring elective or emergency surgery. 2020-05-06
32339304 Treatment for other viral infections in renal transplant recipients often includes a reduction in immunosuppression; however, no current guidelines are available recommending the optimal approach to managing immunosuppression in the patients who are infected with SARS-CoV-2. […] It is currently advised to avoid corticosteroids in the treatment of SARS-CoV-2 outside of critically ill patients. […] Recently published cases describing inpatient care of COVID-19 in renal transplant recipients differ widely in disease severity, time from transplantation, baseline immunosuppressive therapy, and the modifications made to immunosuppression during COVID-19 treatment. 2020-05-26
32339340 At the time of writing, our Government has passed emergency laws (March 11, 2020), with a view to preventing widespread viral infection among the population, which may well lead to an increase in the number of people requiring intensive care unit (ICU) hospital treatment. 2020-04-27
32339382 Data were collected from the clinical records using a standardised questionnaire on maternal general characteristics, any medical or obstetric co-morbidity, course of pregnancy, clinical signs and symptoms, treatment of COVID 19 infection, mode of delivery, neonatal data and breastfeeding. 2020-05-29
32339394 With the COVID-19 pandemic, clinicians and researchers have been suddenly confronted with the difficulty of treatment provision and continuation of clinical trials without face-to-face contact. 2020-04-27
32340018 The difficulties in diagnosis, infection control, and treatment of COVID-19 in maintenance HD patients are discussed in this report. 2020-04-27
32340051 Building a therapeutic relationship and integrating her into an outpatient clinic was possible despite her lack of insight into the illness and her rejection of medical treatment. 2020-04-29
32340090 Objective: To provide a system for warning, preventing and controlling emerging infectious diseases from a macroscopic perspective, using the COVID-19 epidemic data and effective distance model. Methods: The dates of hospitalization/isolation treatment of the first confirmed cases of COVID-19 and the cumulative numbers of confirmed cases in different provinces in China reported as of 23 February, 2020 were collected. 2020-04-28
32340091 Objective: By describing and analyzing the epidemic characteristics and trends of the attack rate, the crude mortality and relevant indexes in Hubei province during the pandemic of COVID-19 to provide comprehensive evaluations of the epidemic trends and the effects of intervention measures. Methods: Based on the case data reported in Hubei province during the COVID-19 epidemic, combined with the important time of major interventions and event, the cumulative attack rate, the sequential increase rate of new cases, baseline increase rate of new cases, the observation- confirmed case conversion rate, the cumulative crude mortality, the daily severe case rate, and the ratio of death to severe were used to describe and analyze the epidemic characteristics in different phases of the COVID-19 epidemic. Results: The epidemic experienced an outbreak phase from January 10 to February 3 with large amount of case reported, a peak phase from February 4 to February 19 with continuous increasing number of new cases and deaths, a platform phase from February 20 to March 3 with balanced diagnosis and treatment number, and a descending phase from March 4 to March 18 with decreased diagnosis and increased treatment number. 2020-04-28
32340092 Based on systematic review of the role of clinical treatment, disease control and scientific research, and combining with the problems exposed by the COVID-19 epidemic, suggestions were proposed to reform and improve the prevention and treatment system for major epidemics diseases in China. […] In clinical treatment, it is necessary to enhance clinical staff’s awareness of law-based reporting, capabilities of syndromic surveillance, the use of infectious diseases reporting systems, and to improve national or local monitoring platforms for emerging infectious diseases detection. […] As for scientific research in major epidemic response, it is essential to strengthen research projects guided by national requests, build research institutions that can “make a final decision”, establish national and regional key laboratories, and strengthen strategic technical reserve for emergency disease control and treatment. 2020-04-28
32340095 In the epidemic period, classified management of COVID-19 cases should be promoted according to needs for control and prevention of isolation and treatment for the purpose of rational allocation of medical resources. 目的: 分析广东省新型冠状病毒肺炎(COVID-19)病例的临床转归及其影响因素,为优化医疗救治及疫情防控的策略提供参考依据。 2020-04-28
32340096 Objective: To explore the feasibility of direct renin inhibitor aliskiren for the treatment of severe patients of COVID-19 with hypertension. Methods: A retrospective case analysis of effectiveness and safety of aliskiren treatment to lower blood pressure in three severe and one critically ill patients of COVID-19 with hypertension. Results: Four patients, two males and two females, with an average age of 78 years (66-87 years), were referred to hospital mainly because of respiratory symptoms. […] On the basis of comprehensive therapy combined with antiviral and oxygenation treatment, aliskiren antihypertensive treatment was taken for three to four weeks. […] The condition improved, and all patients had reached the discharge standard and were discharged. Conclusion: Our preliminary clinical data shows that aliskiren’s antihypertensive therapy is effective and safe for severe COVID-19 patients complicated with hypertension. […] Further clinical aliskiren therapy study is required with more COVID-19 patients.. 目的: 探索直接肾素抑制剂阿利吉伦用于重型新型冠状病毒肺炎(COVID-19)合并高血压患者治疗的可行性。 2020-04-28
32340097 Recognizing the characteristics of three diseases, especially COVID-19, and improving the disease awareness of COVID-19 will help better implement the guidelines of “scientific prevention and treatment, precise implementation” and prevent and control COVID-19. 2020-04-28
32340120 Thus, this special focus is an attempt to hunt down various treatment options to combat COVID-19 based on repurposing drugs that are known to have multiple antiviral properties, including against herpesvirus. 2020-04-29
32340389 Currently, some HIV protease inhibitors (i.e., Lopinavir) are proposed for the treatment of COVID-19, although their effectiveness has not yet been assessed. 2020-04-29
32340531 This review article aims to bridge this gap by briefly reviewing the key points of the evaluation and treatment of patients with COVID-19 in the ambulatory clinic environment. 2020-04-30
32340541 When possible, alternative diagnostic and treatment strategies should be pursued. 2020-04-28
32340549 The purpose of this review is to evaluate the current evidence surrounding the treatment of these patients during this pandemic and to provide evidence-based recommendations with attention to increased risk in this setting. […] Patients with head and neck mucosal malignancy require continued treatment despite the current pandemic state. […] Care must be taken at all stages of treatment to minimize the risk to patients and health care workers while maintaining focus on minimizing use of limited resources. 2020-04-28
32340588 Although the full repercussions of this disease have yet to be realized, the outlined recommendations will guide otolaryngologists in the treatment of pediatric patients in the face of an unprecedented global health crisis. 2020-04-28
32340654 Presented here is a range of information arising from related areas that have impact upon the safety and efficacy of drug therapy in the context of COVID-19. […] Issues include pharmacy practice, clinical therapeutics, and possible new treatments for the virus. 2020-04-30
32340737 Although highly hazardous communicable diseases like Ebola virus disease and MERS are of concern due to their mortality rates and limited treatment options, these same concepts may be applied to the early identification and isolation of patients suspected of having more common communicable diseases like measles and influenza, emphasizing the importance of protocol-based screening in the healthcare environment. 2020-04-30
32340759 So far, no successful specific treatment has been found for this disease. […] Altogether, we highly recommend clinicians to look after those antibiotics with anti-inflammatory activity for both empiric antibiotic therapy and reducing the inflammation to prevent septic shock in patients with diagnosed COVID-19. 2020-04-30
32340833 In this literature review, the causative agent, pathogenesis and immune responses, epidemiology, diagnosis, treatment and management of the disease, control and preventions strategies are all reviewed. 2020-05-05
32341077 Despite international efforts to identify a specific treatment, therapy remains supportive and is principally focused on optimising respiratory function. 2020-04-28
32341142 Compatibility of sample pre-treatment for viral neutralisation or viscous samples with the QIAstat-SARS system were also tested.The QIAstat-Dx Respiratory SARS-CoV-2 Panel demonstrated a comparable sensitivity to the WHO recommended assay with a limit of detection at 1000 copies/mL. 2020-04-28
32341442 Until further data are available, it is recommended that ARB and ACEI medications be continued for the treatment of patients with cardiovascular disease and hypertension, especially those at high risk, according to guideline-directed medical therapy based on the currently available evidence. 2020-04-30
32341630 Currently no vaccine is available and treatment is mainly supportive. 2020-04-30
32341718 But for Hubei Province, the subjects of Wuhan City and Hubei Province were included from the time of admission to the Huoshenshan Hospital to present day in order to ensure that all or the majority of the confirmed and suspected patients were collected for diagnosis and treatment. 2020-05-16
32341721 The reasons for hospitalization were: surgical treatment of cancer (n = 5), complex emergencies (n = 5), treatment of complications linked to cancer or its treatment (n = 3), gastroplasty (n = 1), and stoma closure (n = 1). 2020-04-28
32341910 Hydroxychloroquine and chloroquine have been used as treatment and are being considered as prophylaxis. […] Our patient developed COVID-19 while on hydroxychloroquine and although more work is needed, this calls into question the role of these medications as preventive therapy. 2020-05-06
32342112 We grouped FPMRS conditions into those in which virtual management differs from direct in-person visits and conditions in which treatment would emphasize behavioral and conservative counseling but not deviate from current management paradigms. 2020-05-01
32342184 In the current SARS-CoV-2 pandemic there are many questions regarding the safe treatment of patients with inflammatory rheumatic diseases. 2020-05-08
32342191 In view of the PET/CT findings, home isolation, symptom surveillance, and treatment (in 3/5 patients) were indicated. 2020-05-28
32342479 Of the 43 severely ill patients, 6 (14%) received high-flow nasal cannula oxygen therapy, and 1 (2.3%) received invasive mechanical ventilation. 2020-05-07
32342541 The MD Anderson Head and Neck Surgery Treatment Guidelines Consortium devised the following to provide guidance on triaging head and neck cancer (HNC) surgeries based on multidisciplinary consensus. […] Options for alternative treatment modalities are provided if surgical treatment needs to be deferred. 2020-05-29
32342609 Both patients reported clinically meaningful benefits from nVNS therapy. 2020-05-13
32342676 As COVID-19 has such varied clinical manifestations and case fatality rates, no standard antiviral therapy regimen has been established other than supportive therapy. 2020-04-28
32342677 Since clinical feature of COVID-19 has not been fully evaluated yet, empirical antibacterial agents are frequently combined for the treatment of COVID-19 in addition to antiviral agents, concerning co-existing bacterial pathogens. 2020-04-28
32342863 In that same scenario, postponement or interruption of radiotherapy treatment of COVID-19 positive patients is generally recommended to avoid exposure of cancer patients and staff to an increased risk of COVID-19 infection. […] Case-specific consensus recommendations regarding multimodality treatment strategies and fractionation of radiotherapy are provided. 2020-05-29
32342870 Under its lead, the following measures were implemented in the radiation oncology department: the radiotherapy clinic was divided into different infection control zones with varying levels of protection; special staff and patient infection control training sessions were conducted and appropriate measures deployed; daily symptom testing criteria were implemented for patients undergoing treatment; special rotating schedules and infection control methods were implemented for various staff members such as medical physicists/dosimetrists and radiation therapists; modified radiotherapy workflow and specialized treatment area cleaning and disinfection policies and procedures were designed and executed; and special medical waste disposal methods were implemented. […] We began treating patients using this new COVID-19 radiotherapy treatment workflow and infection control measures on January 30, 2020. 2020-05-27
32342872 We have undertaken a rapid review of published literature on the role of radiotherapy in the multimodality treatment of paediatric cancers governing the European practise of paediatric radiotherapy. […] This review provides evidence-based treatment recommendations during unexpected shortage of paediatric radiotherapy facilities. 2020-05-27
32342878 We performed a review of the literature, as well as national and international treatment guidelines, seeking data in support of the RADS principle (Remote visits, Avoid radiation, Defer radiation, Shorten radiation) [3] as it applies to gastrointestinal cancers. 2020-05-27
32343013 Treatment toxicities from radiation or chemoradiation therapy significantly increase these risks. 2020-05-29
32343086 As nurses in dialysis providing a life-sustaining therapy, we are required to provide an essential service during pandemics and need to thrive in the uncertainty. 2020-04-30
32343118 This article provides general guidance on supporting curative surgical treatment where appropriate and with available resources. 2020-04-30
32343187 Orthopaedic surgeons are not generally considered front-line staff in terms of the treatment of the disease that the novel coronavirus causes compared with anaesthetic and medical colleagues. 2020-04-29
32343410 The clinical features and treatment of pulmonary tuberculosis patients with COVID-19 is unclear and understudied. […] We provide information and experience with treatment of pulmonary tuberculosis cases with confirmed COVID-19 infection. 2020-04-28
32343419 Over the period of operation, a total of 1,124 patients were admitted for treatment. 2020-04-28
32343423 While this makes financial sense, from a medical perspective our population will be left defenseless in the absence of a viable treatment strategy for SARS-CoV-2. 2020-04-28
32343428 Third, when the second and third clusters could not find infectious sources, CECC’s press conference let the public know immediately the epidemic situation, so that people could raise their awareness and seek medical treatment or quarantine. 2020-05-11
32343444 Elderly patients with head and neck cancer are at increased risk of adverse outcomes during and after treatment of head and neck cancer. […] In many cases, prudent treatment plan modification may allow for overall best outcomes. […] Furthermore, recruitment of social services and, when appropriate, palliative care, may allow for optimal management of these patients. 2020-05-29
32343454 These changes raise a lot of questions regarding patient triage and treatment decisions in clinical situations when it is unclear if the workup and management can be postponed. 2020-05-29
32343658 These include virustatic agents that have already been approved for the treatment of other types of viral infection, as well as drugs that are currently used for entirely different purposes. […] Because the virus enters human cells by way of the membrane-associated angiotensin converting enzyme 2 (ACE2), keeping the virus from docking to this receptor is a conceivable treatment approach. […] There is not yet any recommendation for the therapeutic use of any particular agent beyond standard supportive treatment. 2020-05-01
32343745 Sex is an important biological variable that should be considered in the prevention and treatment of COVID-19. 2020-05-13
32343968 Anti-cytokine therapy such as tocilizumab, an IL-6 receptor antagonist, is a potential treatment for COVID-19; however, data regarding the efficacy of this anti-IL-6 therapy are currently lacking. […] Both patients progressed to sHLH despite treatment with tocilizumab, and one developed viral myocarditis, challenging the safety and clinical usefulness of tocilizumab in the treatment of COVID-19-induced CRS. 2020-05-06
32344011 Treatment in intensive care units (ICU) has become a major challenge; therefore, early recognition of severe forms is absolutely essential for timely triaging of patients. 2020-05-29
32344056 Eosinophil levels vary dramatically in a number of clinical settings, especially following eosinophil-targeted therapy, which is now available to selectively deplete these cells. 2020-05-24
32344166 Here we provide an update for clinicians on the recent developments in the virology, diagnostics, clinical presentation, viral shedding, and treatment options for COVID-19 based on current literature. […] We describe the virological characteristics of SARS-CoV-2 and the clinical course of COVID-19 with an emphasis on diagnostic challenges, duration of viral shedding, severity markers and current treatment options. […] For improved management of cases, there is a need to understand test probability of serology, qRT-PCR and radiological testing, and the efficacy of available treatment options that could be used in severe cases with a high risk of mortality. 2020-05-22
32344202 Vaccines that prevent SARS-CoV-2 infection and therapeutics that reduces the risk of severe Covid-19 are thus urgently needed. […] A rapid method to derive antiviral treatment for Covid-19 is the use of convalescent plasma derived hyperimmune globulin. 2020-05-29
32344226 Despite great efforts, there is no treatment of this disease. […] This article describes SARS-CoV-2, disease, prevention and management, treatment and social impact on society. […] However, Unani therapy may be useful along with allopathic treatment. 2020-05-19
32344304 Based on this observation, our proposed hypothesis is that 5-alpha-reductase inhibitors, that are commonly used for BPH treatment, may be one of the factors contributing to poorer prognosis in males. 2020-05-18
32344310 Alternate treatment strategies utilizing clinically available treatments such as hyperbaric oxygen therapy (HBOT), packed red blood cell (pRBC) transfusions, or erthropoiesis-stimulating agent (ESA) therapy were hypothesized to increase oxygenation of tissues by alternative means than standard respiratory and ventilator treatments. […] It was also revealed that alternative treatments currently being considered for COVID-19 such as chloroquine and hydroxychloroquine by increasing hemoglobin production and increasing hemoglobin availability for oxygen binding and acetazolamine (for the treatment of altitude sickness) by causing hyperventilation with associated increasing levels of oxygen and decreasing levels of carbon dioxide in the blood may significantly ameliorate COVID-19 respiratory symptoms. […] In conclusion, is recommend, given HBOT, pRBC, and ESA therapies are currently available and routinely utilized in the treatment of other conditions, that such therapies be tried among COVID-19 patients with serious respiratory conditions and that future controlled-clinical trials explore the potential usefulness of such treatments among COVID-19 patients with respiratory conditions. 2020-05-18
32344313 Despite the immense and ongoing global effort, no efficacious drugs to fight this plague have been identified and patients admitted to the intensive care units (ICU), for respiratory distress, are managed mostly by means of supportive care based on oxygen maintenance. […] TZD were widely used for type-2 diabetes in the first decade of this century and although concerns have been raised for possible side effects associated with long-term treatment, their use has been recently revaluated for their anti-inflammatory properties in numerous medical conditions. 2020-05-18
32344320 The dynamic levels of T lymphocyte in severe group were significantly lower from disease onset, but in the improved subgroup the value of T lymphocyte began to increase after about 15-day treatment and finally returned to the normal level. 2020-05-27
32344438 Questions were addressing the following issues: impact on nuclear medicine diagnostics and therapy, use of recommendations, personal protective equipment, and organizational adaptations. 2020-04-28
32344439 We also report on experiences with implementation of these approaches and treatment outcomes in the first 115 COVID patients. […] A multidisciplinary Task-force Coronavirus initiated measures concerning outpatient testing and counseling, reorganisation and separation of patient flow processes alongside with substantial escalation of inpatient capacities on regular wards and intensive care units. 2020-05-22
32344441 As such, clinical protocols and practice on labor and delivery units must adapt to optimize the safety of patients and health care workers and to better conserve health care resources. 2020-04-28
32344444 For both, plastic and hand surgeons it is crucial to act responsible, minimize the transmission of the virus and aid in reasonable and adequate allocation of resources for the treatment of affected patients during this pandemia. 2020-04-28
32344449 Hydroxychloroquine is an antimalarial drug being tested as a potential treatment for the novel coronavirus disease 2019 (COVID-19) pandemic caused by the severe acute respiratory syndrome coronavirus 2( (SARS-CoV-2. 2020-04-28
32344456 These recommendations focus on seven specific domains including: planning of resources and staffing; modifying the clinical environment; preparing equipment, supplies and drugs; selecting appropriate personal protective equipment; providing adequate oxygen therapy; assessing for and safely performing regional anaesthesia procedures; and monitoring during the conduct of anaesthesia and post-anaesthetic care. 2020-05-14
32344469 So far, no causative therapy nor protective vaccines are available. […] In this situation, useful prognostic parameters and targeted supportive treatment are urgently needed. 2020-04-28
32344526 Previous evidence suggests that RAS may represent an important target for the treatment of lung pathologies, especially for acute respiratory distress syndrome and chronic fibrotic disease. 2020-05-01
32344708 Since no specific therapy for these CoVs is available, any beneficial approach (including nutritional and dietary approach) is worth investigation. 2020-05-29
32345226 We retrospectively analyzed the clinical characteristics and treatment progress of 91 patients diagnosed with COVID-19 in Jingzhou Central Hospital. 2020-04-30
32345443 In view of the current pandemic by SARS-CoV-2 it deems essential to understand the key concepts about the infection: its epidemiological origin, presentation, clinical course, diagnosis and treatment (still experimental in many cases). 2020-05-01
32345485 This convalescent plasma therapy is of particular interest when a vaccine or specific therapy is not yet available for emerging viruses, such as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which causes COVID-19. […] It also includes recommendations for establishing a convalescent plasma program, enhancement considerations for convalescent plasma, and considerations around pathogen reduction treatment of convalescent plasma. […] The immediate use of convalescent plasma provides prompt availability of a promising treatment while specific vaccines and treatments are evaluated and brought to scale. […] Further development of improved convalescent plasma, vaccines and other therapeutics depends on quick generation of additional data on pathogenesis and immune response. 2020-05-05
32345864 Unprepared for this emergency, hospitals have quickly reformulated paths of assistance in an effort to guarantee treatment for infected patients. […] Orthopaedic departments have been focused on elderly traumatology, especially the treatment of femoral neck fractures in patients with coronavirus disease-2019 (COVID-19). […] The purpose of the present study was to evaluate the orthopaedic management strategy for femoral fragility fractures in COVID-19-positive patients with the hypothesis that operative treatment may contribute to the overall stability of the patient. […] Four patients who underwent surgical treatment died of respiratory failure on the first day after surgery (1 patient), the third day after surgery (2 patients), or the seventh day after surgery (1 patient). […] We noted a stabilization of respiratory parameters in 12 COVID-19-positive patients who underwent surgery treatment of proximal femoral fractures. 2020-05-16
32346392 This paper discusses the impact of coronavirus infection on cancer diagnosis and treatment in two leading cancer centres in Pakistan. […] There is an urgent need to evaluate the effect of delays in diagnosis and treatment on cancer stage and treatment, and to decide how to minimise these during likely future cycles of lockdown over the coming months and years. 2020-05-01
32346394 Cancer patients in conflict settings experience significant barriers in accessing chemotherapy and radiotherapy as well as palliative care and psychosocial support. 2020-05-01
32346491 No specific treatment has been reported. […] Herein, we examine the effects of Favipiravir (FPV) versus Lopinavir (LPV)/ritonavir (RTV) for the treatment of COVID-19. […] In this open-label nonrandomized control study, FPV showed significantly better treatment effects on COVID-19 in terms of disease progression and viral clearance; if causal, these results should be important information for establishing standard treatment guidelines to combat the SARS-CoV-2 infection. 2020-05-01
32346492 The second step is to prescribe a blood purification treatment for patients with COVID-19. 2020-05-01
32346593 This paper reviews the published literature, guidelines and consensus, and summarizes the clinical and imaging characteristics of COVID-19, in order to provide a reliable basis for early diagnosis and treatment. 2020-05-11
32346656 We implemented a novel remote RO SBRT coverage practice, requiring it to be reliable, of high audio and visual quality, timely, and the same level of specialty care as our current in-person treatment coverage practice. […] The time from CBCT to treatment was calculated before and after implementation to determine timeliness of remote coverage. […] Comfort levels with audio/visual communication as well as overall comfort in comparison to in-person RO coverage was evaluated using Likert scale surveys after treatment. […] Remote RO SBRT coverage was successfully implemented in 14/15 fractions with 3 observed process failures that were all corrected before treatment. […] Average times of pre-treatment coverage before and after implementation were 8.74 and 8.51min, respectively. 2020-05-01
32346873 The demographic characteristics, clinical data, treatment, and outcomes of SARS-CoV-2 infected patients without any symptoms were analyzed. 2020-05-13
32347053 Since SARS-CoV-2 and SARS-CoV are closely related, previous findings on SARS-CoV are highly relevant to a better understanding as well as diagnosis, treatment, prevention and control of SARS-CoV-2. […] In this review, we highlight recent progresses in the field; compare the biological characteristics of SARS-CoV and SARS-CoV-2; summarize the urgently-needed diagnostic, treatment, prevention and control options; and provide future perspectives for the outcome of the outbreak and research questions to be answered, including some of the difficulties in vaccine development. 2020-05-01
32347201 Predictors of lower odds of discharge were age > 65 years, antiviral treatment and for severe disease, lactate dehydrogenase > 300 mg/dL. 2020-05-04
32347453 The department of surgery played a leading role in establishing clinical protocols, guidelines, and policies in preparation for a surge of COVID-19 patients. 2020-05-05
32347743 Small studies have shown a potential benefit of chloroquine/hydroxychloroquine ± azithromycin for the treatment of COVID-19. […] The maximum QTc during treatment was significantly longer in the combination group vs the monotherapy group (470.4 ± 45.0 ms vs. […] Although use of these medications resulted in QT prolongation, clinicians seldomly needed to discontinue therapy. 2020-04-29
32347745 The current outbreak of SARS-CoV-2 has and continues to put huge pressure on intensive care units (ICUs) worldwide. 2020-05-29
32347761 For the dermatology community, this interruption to the healthcare system can lead to delays in the diagnosis and treatment of melanoma. 2020-05-13
32347772 Identified strategies included early recognition of the threat and rapid activation of national response protocols led by national leadership; rapid establishment of diagnostic capacity; scale-up of measures for preventing community transmission; and redesigning the triage and treatment systems, mobilizing the necessary resources for clinical care. 2020-05-04
32348003 Worldwide Coronavirus Disease 2019 (COVID-19) epidemic makes the management of acute myocardial infarction (AMI) more complicated, effective treatment without further dissemination is thus quite challenging. 2020-05-01
32348025 Furthermore, elective clinics and operations have been reduced in order to mobilize manpower to the acute specialties combatting the outbreak; appropriate differentiation between patients who require immediate care and those who can receive telephone consultation or whose treatment might viably be postponed is therefore crucial. 2020-04-29
32348042 Furthermore, treatment options against COVID-19 disease and adequate adjustment of immunosuppression in at risk patients remain a concern. 2020-05-01
32348043 Proper mitigation strategies in the clinic and use of less resource-heavy but equivalent treatment alternatives often allow optimal cancer care. 2020-05-01
32348044 Thrombocytopenia and procoagulant state are associated with severe courses of COVID-19, requiring an individualized therapy. 2020-05-01
32348046 Patients under immunosuppressive treatment are considered at high risk of severe outcome and are protected accordingly by the Swiss authorities. […] However, current, scarce scientific evidence suggests that patients under immunosuppressive therapy do not necessarily develop severe COVID-19 presentations. […] Therefore, the current guidelines recommend pursuing the treatment throughout the pandemic. 2020-05-01
32348055 Up to 5 % of COVID-19 infected patients develop severe acute hypoxemic respiratory failure requiring invasive mechanical ventilation as supportive treatment. […] Apart from early antiviral and anti-inflammatory treatment, the management of COVID-19 patients is mainly applying protective mechanical ventilation, to support the injured lungs. 2020-05-01
32348056 Alongside organizational challenges, clinical issues such as rapid respiratory distress, clinical suspicions with negative PCR and treatment uncertainties in the absence of sufficient evidence were overcome. 2020-05-01
32348166 With the capability of inducing elevated expression of ACE2, the cellular receptor for SARS-CoV-2, angiotensin II receptor blockers or angiotensin-converting enzyme inhibitors (ARBs/ACEIs) treatment may have a controversial role in both facilitating virus infection and reducing pathogenic inflammation. […] 126 COVID-19 patients with preexisting hypertension at Hubei Provincial Hospital of Traditional Chinese Medicine (HPHTCM) in Wuhan from January 5 to February 22, 2020 were retrospectively allocated to ARBs/ACEIs group (n=43) and non-ARBs/ACEIs group (n=83) according to their antihypertensive medication. 125 age- and sex-matched COVID-19 patients without hypertension were randomly selected as non-hypertension controls. […] In addition, the medication history of 1942 hypertension patients that were admitted to HPHTCM from November 1 to December 31, 2019 before COVID-19 outbreak were also reviewed for external comparison. 2020-04-29
32348232 O2 saturation was 87% (without O2 therapy). 2020-04-29
32348233 We report 3 patients with coronavirus disease who had a decline in respiratory status during their hospital course that responded well to intravenous steroids and interleukin-6 receptor antagonist therapy. 2020-04-29
32348485 Currently, the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) disease 2019 (COVID-19) has been reported in almost all countries globally, and no effective therapy has been documented for COVID-19 and the role of convalescent plasma therapy is unknown. […] In conclusion, convalescent plasma treatment can discontinue SARS-CoV-2 shedding but cannot reduce mortality in critically end-stage COVID-19 patients, and treatment should be initiated earlier. 2020-05-06
32348554 We wish to bring your attention to the PsoPROTECT (Psoriasis Patient Registry for Outcomes, Therapy and Epidemiology of Covid-19 infecTion) and SECURE-AD (Surveillance Epidemiology of Coronavirus Under Research Exclusion-Atopic Dermatitis) registries; two urgent global initiatives that address an unmet need for delineating the determinants of COVID-19 outcomes in the common cutaneous immune-mediated inflammatory diseases (IMIDs) psoriasis and atopic dermatitis. 2020-04-29
32348585 Imaging modalities such as chest radiography, thoracic and cardiovascular ultrasound, and computed tomography have roles in the diagnosis, prognosis, monitoring, and therapy of COVID-19. 2020-04-29
32348588 Here, we provide an overview of the known clinical features and treatment options for COVID-19. […] To date, there is no evidence of any effective treatment for COVID-19. […] The main therapies being used to treat the disease are antiviral drugs, chloroquine/hydroxychloroquine and respiratory therapy. […] Specifically designed randomized clinical trials are needed to determine the most appropriate evidence-based treatment modality. 2020-05-13
32348598 IBD medication adherence should be encouraged to prevent disease flare but where possible high-dose systemic corticosteroids should be avoided. […] The primary focus should remain on keeping bowel inflammation controlled and encouraging medication adherence. 2020-05-26
32348692 Use of inhaled corticosteroids (ICS) was associated with lower expression of ACE2 and TMPRSS2, but treatment with triamcinolone acetonide (TA) did not decrease expression of either gene. 2020-05-22
32348711 Palliative care is an important component of health care in pandemics, contributing to symptom control, psychological support, and supporting triage and complex decision making. […] Concerns included scarcity of personal protective equipment, a lack of hospice-specific guidance on COVID-19, anxiety about needing to care for children and other relatives, and poor integration of palliative care in the acute planning response. […] Governments must urgently recognise the essential contribution of hospice and palliative care to the COVID-19 pandemic and ensure these services are integrated into the health care system response. 2020-05-15
32349032 Radiographic technologies and tools, including Computed tomography (CT) and Chest X-ray (CXR), were applied for initial screening and follow-up, from which provides detail diagnosis with specific pathologic features for staging and treatment arrangement. 2020-04-29
32349053 With limited ability to contain the virus and relatively high transmissibility and case fatality rates, governmental institutions and pharmaceutical companies are racing to find therapeutics and vaccines that target this novel coronavirus. […] This is another missed opportunity to obtain pregnancy-specific safety and efficacy data, because therapeutics developed for men and nonpregnant women may not be generalizable to pregnant women. 2020-05-26
32349115 The proposed doses of chloroquine (CQ) and hydroxychloroquine (HCQ) for treatment of COVID-19 (1000 mg/day for 10 days, CQ; 800 mg first day then 400 mg/day for 5 days, HCQ) in many guidelines worldwide, are considerably higher than the maximum recommended daily safe doses of both agents (≤2.3 mg/kg/day, CQ; ≤5.0 mg/kg/day, HCQ) for development of retinal toxicity. 2020-05-01
32349133 The novel coronavirus 2019 (COVID-19) is clinically characterized by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which is responsible for a high number of patients needing mechanical ventilation or intensive care units treatment and for the elevated mortality risk. […] Furthermore, we discussed the biologic plausibility of the thrombotic risk in SARS-CoV-2 and the potential use of an antithrombotic treatment. 2020-04-29
32349517 So far, there is no specific anti-coronavirus therapy approved for the treatment of COVID-19. […] For a better popularization of TCM, governments have made several advances in regulations and policies for treatment and measures of novel coronavirus pneumonia (NCP). […] Therefore, on the basis of epidemiology and virology information, we reviewed relevant meta-analysis and clinical studies of anti-coronavirus therapeutics by TCM, in the aspect of mortality, symptom improvement, duration and dosage of corticosteroid, incidence of complications and the like. 2020-04-30
32349902 In these unprecedented times, OMFS surgeons are faced with dilemmas over the priority of treatment, safety of staff, safety of patients and the most appropriate use of available resources. 2020-05-02
32349982 Due to the frequent presence of interstitial lung disease and widespread use of immunosuppressive treatment, systemic sclerosis (SSc) patients may be considered at risk for a more severe disease course and higher mortality when they develop Severe Acute Respiratory Syndrome - Coronavirus - 2 (SARS-CoV-2) virus infection. 2020-05-22
32350134 The patients diagnosed as severe or critical COVID-19 in The First Affiliated Hospital of University of Science and Technology of China (Anhui Provincial Hospital) and Anhui Fuyang Second People’s Hospital were given tocilizumab in addition to routine therapy between 5 and 14 February 2020. […] Within 5 d after tocilizumab, 15 of the 20 patients (75.0%) had lowered their oxygen intake, and 1 patient needed no oxygen therapy. […] The percentage of lymphocytes in peripheral blood, which decreased in 85.0% of patients (17/20) before treatment (mean, 15.52 ± 8.89%), returned to normal in 52.6% of patients (10/19) on the fifth day after treatment. […] Preliminary data show that tocilizumab, which improved the clinical outcome immediately in severe and critical COVID-19 patients, is an effective treatment to reduce mortality. 2020-05-22
32350543 Due to their limited technical features, home respirators are not suitable for the treatment of severely affected patients but can be used for weaning after respiratory improvement, which means that intensive care respirators are available again more quickly. 2020-05-11
32350584 The collected data included patients’ demographics (age and gender), injury-related (injury type, fracture location, injury mechanism, places where fracture occurred), and treatment modality. 2020-05-07
32350686 According to the WHO, Centers for Disease Control and Prevention (CDC), and the US Food and Drug Administration (FDA), currently there are no medicines or vaccines that have been claimed to be useful in the prevention or treatment of COVID-19. […] According to the CDC and Chinese treatment guidelines for COVID-19, chloroquine, hydroxychloroquine, lopinavir/ritonavir, and one of the investigational agents (remdesivir) are recommended in critically ill older patients. […] The use of other potential drugs reported in different studies may be considered if treatment with first-line drugs is ineffective. […] There are currently no complete data available from large randomized clinical trials (RCTs) to provide clinical guidance on the use, dosing, or duration to validate the effective role, safety profile, and adverse effects of all of the trial drugs for prophylaxis or treatment of COVID-19. 2020-05-29
32350773 Some reported challenges in accessing HIV testing, prevention and treatment services. 2020-05-09
32350794 In this emergency situation, several expectations have been raised by the scientific community about the role that artificial intelligence can have in improving the diagnosis and treatment of coronavirus infection, and SIRM wishes to deliver clear statements to the radiological community, on the usefulness of artificial intelligence as a radiological decision support system in COVID-19 positive patients. 2020-05-13
32350796 The current global outbreak of COVID-19 represents a major challenge in terms of epidemiology, contagiousness, treatment, as well as clinical and radiological behavior of this disease. 2020-05-13
32350818 In the battle against the SARS-CoV‑2 pandemic, chloroquine has emerged as a new potential therapeutic option for the treatment of infected patients. […] A baseline electrocardiogram (ECG) and ECGs recorded during chloroquine treatment were retrospectively collected in patients suspected of having COVID-19. […] A total of 95 patients had a baseline ECG recording and at least one ECG recording during chloroquine therapy. […] Chloroquine treatment resulted in a mean QTc prolongation of 35 ms (95% CI 28-43 ms) using computerised interpretation and 34 ms (95% CI 25-43 ms) using manual interpretation. […] No torsade de pointes was observed during chloroquine treatment. […] After manual review, 22 patients (23%) had a QTc interval exceeding 500 ms during chloroquine treatment. […] None of these patients had a prolonged QTc interval prior to the initiation of chloroquine treatment. 2020-05-25
32350857 No major stakeholder seems to have considered how a pandemic deprives patients with a surgical condition of resources, with patients disproportionally affected owing to the nature of treatment (use of anaesthesia, operating rooms, protective equipment, physical invasion and need for perioperative care). 2020-05-06
32350861 COVID-19 may also be such a defining moment for clinical pharmacology in terms of its role in drug development and therapy. 2020-04-30
32350928 In addition, the known and potent immunomodulatory effects of these agents which support their use in the treatment of auto-immune conditions, and provided a component in the original rationale for their use in patients with COVID-19, may, in fact, undermine their utility in the context of the treatment of this respiratory viral infection. […] Given these facts and the growing uncertainty about these agents for the treatment of COVID-19, it is clear that at the very least thoughtful planning and data collection from randomized clinical trials are needed to understand what if any role these agents may have in this disease. […] In this article, we review the datasets that support or detract from the use of these agents for the treatment of COVID-19 and render a data informed opinion that they should only be used with caution and in the context of carefully thought out clinical trials, or on a case-by-case basis after rigorous consideration of the risks and benefits of this therapeutic approach. 2020-05-06
32351121 This raises the question whether the use of RAS inhibitors, the backbone of treatment of cardiovascular, neurovascular, and kidney diseases could increase the susceptibility for coronavirus infection or unfortunate outcomes of COVID-19. 2020-05-25
32351196 COVID-19 patients have characteristic reproducible laboratory findings and present a major challenge due to their illness severity and required treatment length. none. not relevant. 2020-05-01
32351851 Hydroxychloroquine therapy was started, and the patient responded favorably with improvement of symptoms. 2020-05-05
32351873 To systematically review and evaluate the pattern of COVID-19 and the treatment plans. […] The current research taking place to overcome this complex disease and the urgent need to develop improved therapeutics are also discussed. […] Herein, we present an epidemiological overview of the currently available information on the treatment claimed to have helped to bring the situation under control. 2020-05-05
32352309 OBJECTIVE. Because CT plays an important role in diagnosis, isolation, treatment, and effective evaluation of coronavirus disease (COVID-19), infection prevention and control management of CT examination rooms is important. CONCLUSION. We describe modifications to the CT examination process, strict disinfection of examination rooms, arrangement of waiting areas, and efforts to increase radiographers’ awareness of personal protection made at our institution during the COVID-19 outbreak. 2020-04-30
32352401 Presenting signs and symptoms, laboratory and imaging findings, treatment, and complications were recorded from electronic medical records (EMRs). 2020-05-05
32352633 Due to extended transportation delays to a cathlab, he received intravenous fibrinolytic therapy, which failed. […] Reperfusion was achieved with rescue coronary angioplasty, but the patient experienced two episodes of acute stent thrombosis at 2- and 36-hr following admission and despite optimal medical therapy. 2020-04-30
32352637 Increased vigilance and aggressive treatment of patients with obesity and COVID-19 are warranted. 2020-04-30
32352944 Interferon-alpha (5 million U twice daily by inhalation), lopinavir/ritonavir (400/100 mg twice daily orally), as well as chloroquine (500 mg twice daily orally for 10 days) and azithromycin (500 mg twice per day) cause a milder course of the disease and reduce the duration of treatment. 2020-05-04
32353441 Chest drain represent the first line treatment. 2020-05-02
32353547 Nigeria’s current national health systems cannot effectively respond to the growing needs of already infected patients requiring admission into intensive care units for acute respiratory diseases and severe acute respiratory syndrome (SARS COV-2) pneumonia. 2020-05-29
32353597 To our knowledge, this is the first reported investigation of a possible role of interleukin-17 target therapy in patients with lung cancer and concomitant severe acute respiratory syndrome-coronavirus-2 infection. 2020-05-16
32353740 We are suggesting here a strategy for the COVID-19 treatment that could be effective in curing the patients in the current scenario when no efficient medicine or Vaccine is currently available, and Clinicians solely depend upon the performing trials with drugs with known antiviral activities. 2020-05-18
32353825 Burns are an acute-care condition, and burn treatment needs to be initiated before COVID-19 infection status can be excluded. […] The key step to infection prevention is to identify risk points of infection exposure, strengthen the protection against those risk points, and formulate an appropriate diagnosis and treatment protocol. […] Following an in-depth study of the latest literature on COVID-19 diagnosis and treatment, we reviewed the protocols surrounding hospitalization of patients with extensive burns (area≥50 %) in our hospital from February 2009 to February 2019 and, in accordance with the epidemiological characteristics of COVID-19, developed an algorithm for protection during diagnosis and treatment of burns. […] Therefore, the aspects of medical protection and the diagnosis and treatment of burns appear to be particularly important during the prevention and control of the COVID-19. […] This algorithm was followed for 4 patients who received emergency treatment in February 2020 and were hospitalized. […] During the COVID-19 epidemic, the early stages of emergency treatment for patients with extensive burns requiring the establishment of venous access for rehydration, endotracheal intubation or tracheostomy, wound treatment, and surgery are the risk points for exposure to infection. […] The implementation of effective, appropriate-grade protection and formulation of practical treatment protocols can increase protection of healthcare worke and reduce the risk of COVID-19 infection exposure. 2020-05-21
32353870 Furthermore, treatment options for COVID-19 infection are currently limited. 2020-05-08
32354030 Taking into consideration the mortality rate of COVID-19, about 5-7%, and the percentage of positive patients admitted to intensive care units being 9-11%, it should be mandatory to consider and take all necessary measures to contain the COVID-19 infection. […] Moreover, given the recent evidence in different hospitals suggesting IL-6 and TNF-α inhibitor drugs as a possible therapy for COVID-19, we aimed to highlight that a dietary intervention could be useful to prevent the infection and/or to ameliorate the outcomes during therapy. 2020-05-05
32354181 More research on prevention and treatment is needed according to an analysis of term density. 2020-05-06
32354369 The patient received combination of interferonalfa-1b and ribavirin, lopinavir and ritonavir for antiviral treatment at different stages. […] Other medication was also given to him in combination for anti-inflammation, intestinal microbial regulation, phlegm elimination, liver protection and pulmonary fibrosis prevention purposes. […] We provided oxygen supply to him using BIPAP ventilator and high-flow humidification oxygen therapy instrument to facilitate respiration. […] This case report described an effective supportive medication scheme to treat SARS-COV-2 infected patient and emphasized the necessity of detection of the viral genome using BALF samples and its significance in the diagnosis and prognosis of the disease. 2020-05-04
32354491 The hospital network of our public health system has provided most of the resources for the treatment of patients affected by the infection. 2020-05-03
32354634 At admission, all had immunosuppression withdrawn and were started on methylprednisolone 16 mg/day, all but one was commenced on antiviral therapy and hydroxychloroquine with doses adjusted for kidney function. […] During a median follow-up of seven days, 87% experienced a radiological progression and among those 73% required escalation of oxygen therapy. 2020-05-27
32354637 Overall, two were managed on an out-patient basis, but the remaining five required hospital admission, four in intensive care units. […] Most patients had their immunosuppression reduced and were treated with supportive therapy. 2020-05-28
32354734 Palliative care is an important component of the medical response to pandemics and other health emergencies. […] The principles of palliative care do not change, but the practice of palliative care has to change as a result of factors such as greater demand and infection control measures. […] This article makes suggestions for palliative care provision during a pandemic (in developed countries), based on a limited review of the literature and personal experience of the ongoing pandemic (COVID-19 infection). 2020-05-01
32354798 We prospectively assessed the medical records, laboratory results, chest CT images and use of medication in a cohort of patients presenting to two designated covid-19 treatment centres in Sichuan, China. […] Outcomes of interest included death, admission to an intensive care unit (ICU), need for mechanical ventilation, treatment with vasoactive agents and classification of disease severity. […] Patients with acute myocardial injury were older, with a higher prevalence of pre-existing cardiovascular disease and more likely to require ICU admission (62.5% vs 24.7%, p=0.003), mechanical ventilation (43.5% vs 4.7%, p<0.001) and treatment with vasoactive agents (31.2% vs 0%, p<0.001). 2020-05-01
32354800 Specific cardiovascular considerations are also necessary in supportive treatment with anticoagulation, the continued use of renin-angiotensin-aldosterone system inhibitors, arrhythmia monitoring, immunosuppression or modulation, and mechanical circulatory support. 2020-05-14
32354990 Patients with IBD are at increased risk of infection, especially when they have active disease and are taking immunosuppressive therapy. […] Data regarding age, sex, IBD (type, treatments and clinical activity), other comorbidities (Charlson Comorbidity Index (CCI)), signs and symptoms of COVID-19 and therapies were compared with COVID-19 outcomes (pneumonia, hospitalisation, respiratory therapy and death). […] Thirty-six patients had COVID-19-related pneumonia (46%), 22 (28%) were hospitalised, 7 (9%) required non-mechanical ventilation, 9 (11%) required continuous positive airway pressure therapy, 2 (3%) had endotracheal intubation and 6 (8%) died. 2020-05-28
32355107 It is important to balance the need for access to healthcare services, including testing and treatment for sexually transmitted infections (STIs). 2020-05-01
32355450 These data were compared to the results of the tests conducted pre- and post-treatment. […] However, treatment group students who spent more time using mobile devices to learn the language did not display better performance compared to those who spent minimal time. 2020-05-01
32355509 Indeed, while the currently recommended treatment for uncomplicated acute appendicitis is surgical appendectomy, the non-surgical alternative of medical management by antibiotic therapy alone has been widely evaluated by high-quality studies in the literature. […] Insofar as the main limitation of exclusively medical treatment of uncomplicated acute appendicitis is the risk of recurrent appendicitis, this treatment option represents an alternative of choice to reduce the intra-hospital overload in this context of health crisis.The aim of this work is therefore to provide physicians and surgeons with a practical guide based on a review of the literature on the medical treatment of uncomplicated acute appendicitis in adults, to offer this alternative treatment to the right patients and under good conditions, especially when access to the operating room is limited or impossible. 2020-05-01
32355564 Dornase alfa should be considered for clinical trials in treatment of severe COVID-19. 2020-05-21
32355607 They are concerned about their risk of developing COVID-19 as many are immune suppressed from their disease and/or treatment, whether they should stop their advanced therapies, if they will have a worse outcome if/when infected due to their underlying medication condition(s) and if they will have drug availability, especially with press (without much data) coverage suggesting hydroxychloroquine may be used in COVID-19 infection causing diversion of medication supply. […] The long term effects of the pandemic in patients with rheumatic diseases will not be known until much later and likely include stressors flaring disease (fear, illness, job loss, social isolation), post-traumatic stress, flaring due to stopping medications, less physician visits with subsequent under-treatment, and increases in chronic concomitant fatigue, pain, fibromyalgia. 2020-05-01
32355837 Unfortunately, like the previous Coronavirus outbreaks, there is no definite antiviral therapy for the treatment of confirmed cases and hence preventing ourselves from contracting 2019-nCoV is the best way to prevent it from becoming pandemic. […] Herein, we aim to discuss the latest updates on the origin, genomic characteristics, diagnosis, treatment options and current efforts being made by international health organizations with regards to the 2019-nCoV outbreak. 2020-05-05
32356252 These two medications may precipitate ventricular dysrhythmias, necessitating cardiac and electrolyte monitoring, and in severe cases, treatment with epinephrine and high-doses of diazepam. […] Recombinant protein therapeutics may cause serum sickness or immune complex deposition. […] Here, we review the use, mechanism of action, and toxicity of proposed COVID-19 therapeutics. 2020-05-08
32356301 Past outbreaks of infectious diseases (Ebola and Zika virus) have shown that maladaptive behavior, related to increased psychological stress and anxiety, can interfere with the implementation of treatment strategies and actions and can contribute to a further spread. 2020-05-29
32356626 Using an observational database from 169 hospitals in Asia, Europe, and North America, we evaluated the relationship of cardiovascular disease and drug therapy with in-hospital death among hospitalized patients with Covid-19 who were admitted between December 20, 2019, and March 15, 2020, and were recorded in the Surgical Outcomes Collaborative registry as having either died in the hospital or survived to discharge as of March 28, 2020. 2020-05-09
32356628 We assessed the relation between previous treatment with ACE inhibitors, angiotensin-receptor blockers, beta-blockers, calcium-channel blockers, or thiazide diuretics and the likelihood of a positive or negative result on Covid-19 testing as well as the likelihood of severe illness (defined as intensive care, mechanical ventilation, or death) among patients who tested positive. […] Using Bayesian methods, we compared outcomes in patients who had been treated with these medications and in untreated patients, overall and in those with hypertension, after propensity-score matching for receipt of each medication class. […] There was no association between any single medication class and an increased likelihood of a positive test. 2020-05-16
32356760 Lung infection or pneumonia is the common complication of COVID-19, and imaging techniques, especially computed tomography (CT), have played an important role in diagnosis and treatment assessment of the disease. […] CT, positron emission tomography - CT (PET/CT), lung ultrasound, and magnetic resonance imaging (MRI) have been used for detection, treatment, and follow-up. 2020-05-01
32356863 Administration of hydroxychloroquine with or without azithromycin for the treatment of coronavirus disease 2019 (COVID-19)-associated pneumonia carries increased risk of corrected QT (QTc) prolongation and cardiac arrhythmias. […] In this cohort study, patients who received hydroxychloroquine for the treatment of pneumonia associated with COVID-19 were at high risk of QTc prolongation, and concurrent treatment with azithromycin was associated with greater changes in QTc. […] Clinicians should carefully weigh risks and benefits if considering hydroxychloroquine and azithromycin, with close monitoring of QTc and concomitant medication usage. 2020-05-06
32356908 Based on our analysis, delaying the onset of adaptive immune responses during the early phase of infections may be a potential treatment option for high-risk COVID-19 patients. 2020-05-13
32356910 This review was conducted to evaluate the effectiveness of CPT therapy in COVID-19 patients based on the publications reported till date. […] The main findings from available data are as follows: (a) Convalescent plasma may reduce mortality in critically ill patients, (b) Increase in neutralizing antibody titers and disappearance of SARS-CoV-2 RNA was observed in almost all the patients after CPT therapy, and (c) Beneficial effect on clinical symptoms after administration of convalescent plasma. […] Based on the limited scientific data, CPT therapy in COVID-19 patients appears safe, clinically effective, and reduces mortality. 2020-05-13
32356955 In the setting of anticipated resource scarcity in the future, we are forced to reconsider fibrinolytic therapy in our management algorithms. 2020-05-15
32357072 Epidemiologic, demographic, clinical, laboratory, treatment, and outcome data were analyzed. Results: The average age of the 28 patients was 68.6 ± 9.0 years. 2020-05-01
32357074 Although extracorporeal membrane oxygenation and other modalities of mechanical cardiopulmonary support are increasingly being utilized in the treatment of respiratory and circulatory failure refractory to conventional management, their role and efficacy as support modalities in the present pandemic are unclear. […] We review the rapidly changing epidemiology, pathophysiology, emerging therapy, and clinical outcomes of coronavirus disease 2019; and based on these data and previous experience with artificial cardiopulmonary support strategies, particularly in the setting of infectious diseases, provide consensus recommendations from American Society for Artificial Internal Organs. 2020-05-05
32357281 Being semi-emergent in nature, treatment for these patients is currently on hold or delayed in most centers across the country. 2020-05-13
32357288 These groups include infertility patients (eg, azoospermic and cryptozoospermic) undergoing medical or surgical treatment to improve sperm quantity and quality, as well as males of reproductive age affected by inflammatory and systemic auto-immune diseases who are about to start treatment with gonadotoxic drugs or who are under remission. 2020-05-23
32357380 A questionnaire was distributed to head and neck surgeons assessing opinions related to treatment and concerns for the safety of patients, self, family, and staff. […] Surgeons continued to recommend primary surgical treatment for oral cavity cancers. […] Respondents were more likely to consider non-surgical therapy for patients with early glottic cancers and HPV-mediated oropharynx cancer. 2020-05-01
32357503 Due to the scientific community’s efforts, there is an increasing body of published studies describing the virus’ biology, its transmission and diagnosis, its clinical features, its radiological findings, and the development of candidate therapeutics and vaccines. […] Only by working with a complete set of histological samples obtained through autopsy can one ascertain the exact cause(s) of death, optimize clinical management, and assist clinicians in pointing out a timely and effective treatment to reduce mortality. […] Death can teach us not only about the disease, it might also help with its prevention and, above all, treatment. 2020-05-04
32357553 Current treatment plans are still under investigation due to a lack of understanding of COVID-19. […] Hence, repurposing these drugs with a proper formulation is needed to improve the safety and efficacy for COVID-19 treatment. 2020-05-05
32357575 There is an urgent need to share expertise and clinical management skills with geriatricians as well as the need for early diagnosis to start treatment at the earliest convenience in the community, with the aim to avoid the collapse of intensive care units. 2020-05-04
32357975 Given this sense of randomness, and in the absence of a definitive treatment, medical professionals can feel helpless. 2020-05-02
32357994 Cancer patients are presumed to be at increased risk from COVID-19 infection fatality due to underlying malignancy, treatment-related immunosuppression, or increased comorbidities. 2020-05-06
32358230 Specific recommendations were made for surgical treatment of cancer, trauma and semi-urgent reconstructive procedures based on available data and literature. 2020-05-15
32358232 Although extracorporeal membrane oxygenation and other modalities of mechanical cardiopulmonary support are increasingly being utilized in the treatment of respiratory and circulatory failure refractory to conventional management, their role and efficacy as support modalities in the present pandemic are unclear. […] We review the rapidly changing epidemiology, pathophysiology, emerging therapy, and clinical outcomes of COVID-19; and based on these data and previous experience with artificial cardiopulmonary support strategies, particularly in the setting of infectious diseases, provide consensus recommendations from ASAIO. 2020-05-30
32358234 The threat of COVID-19 is particularly serious as there is no vaccine and no specific antiviral therapy. 2020-05-14
32358406 The patients continued to be given oxygen by mask and received antitussive, phlegm-dispelling treatment. 2020-05-06
32358568 Patients with malignant diseases are assumed to be at increased risk for a worse outcome of SARS-CoV-2 infection, and therefore, guidance regarding prevention and management of the infection as well as safe administration of cancer-therapy is required. 2020-05-07
32358689 Although chest X-ray (CXR) is considered not sensitive for the detection of pulmonary involvement in the early stage of the disease, we believe that, in the current emergency setting, CXR can be a useful diagnostic tool for monitoring the rapid progression of lung abnormalities in infected patients, particularly in intensive care units. 2020-05-13
32358691 Our results may help to identify the highest-risk patients and those who require specific treatment strategies. 2020-05-13
32358791 Whilst the authors reported an infection that occurred during therapy with an IL-23 inhibitor, we would like to briefly report one that occurred during therapy with an IL-17 inhibitor. 2020-05-12
32358833 In this review, we identify opportunities for drug discovery in the treatment of COVID-19 and in so doing, provide a rational roadmap whereby pharmacology and pharmacologists can mitigate against the global pandemic. 2020-05-08
32358880 There are three proposed major strategies to address care for patients with cancer in this SARS-CoV-2 pandemic with postponing treatment for those with stable cancer, increasing personal protection provisions for patients with cancer, and increasing monitoring if a patient becomes infected with SARS-CoV-2. 2020-05-02
32358890 A variety of repurposed drugs and investigational drugs such as remdesivir, chloroquine, hydroxychloroquine, ritonavir, lopinavir, interferon-beta, and other potential drugs have been studied for COVID19 treatment. 2020-05-22
32358954 On secondary analysis, 1450/2010 (72%) of patients reported received antimicrobial therapy. 2020-05-06
32358956 However, no significant difference in level of IgM and IgG antibody between positive and negative patients of nucleic acid test after treatment was found. 2020-05-06
32359035 No agent has yet been proven to be effective for the treatment of patients with severe COVID-19. […] Future controlled trials in patients with severe illness are urgently needed to confirm the definite benefit with IL-6 target therapy. 2020-05-29
32359182 we read with great interest the article entitled "Should SARS-CoV-2 influence immunosuppressive therapy for autoimmune blistering diseases? […] This is the first report of COronaVIrus DIsease 2019 (COVID-19) in a patient affected by autoimmune blistering disease (ABD) during immunosuppressive treatment (i.e. azathioprine). […] The authors conclude that it is crucial to learn of more cases of ABD patients under immunosuppressive treatment who have developed COVID-19, in order to better quantify the risk of infection under immunosuppressive therapy. 2020-05-02
32359201 The delayed and strong adaptive immune response (high affinity IgM and IgG antibodies) that follows, causes severe inflammation and triggers mediator cascades (complement, coagulation, and cytokine storm) leading to complications often requiring intensive therapy and being, in some patients, fatal. […] This “quantitative and time-sequence dependent” model has several implications for prevention, diagnosis, and therapy of COVID-19 at all ages. 2020-05-02
32359203 With supportive care as the current mainstay of treatment, the fatality rate of COVID-19 is 6.9%. […] There are currently several trials assessing the efficacy of different antivirals as treatment. […] In this study, the literature currently available on CQ and HCQ as treatment of COVID-19 was surveyed using EMBASE, PubMed, Cochrane Library, MedRxiv, and one clinical trial registry. 2020-05-29
32359205 Seven patients (58%) were on maintenance treatment with immunomodulators/biologics, of these 4 with combined therapy (33%). 2020-05-02
32359771 With the possibility that a considerable proportion of the world’s population soon could receive COVID-19 pharmacotherapies with torsadogenic potential for therapy or postexposure prophylaxis, this document serves to help health care professionals mitigate the risk of drug-induced ventricular arrhythmias while minimizing risk of COVID-19 exposure to personnel and conserving the limited supply of personal protective equipment. 2020-05-06
32359788 Specifically, it has been used in the treatment of many viral infections with varying degrees of clinical efficacy. 2020-05-05
32359846 At the same time, delaying treatment such as radiotherapy in cancer patients can be detrimental. 2020-05-03
32359937 The purpose of this study was to highlight the importance of timely brachytherapy treatment for patients with gynecologic, breast, and prostate malignancies, and provide a framework for brachytherapy clinical practice and management in response to the COVID-19 pandemic. […] There may be a significant negative impact on oncologic outcomes for patients with gynecologic malignancies who have a delay in the timely completion of therapy. […] Delay of prostate or breast cancer treatment may also impact oncologic outcomes. […] If a treatment delay is expected, endocrine therapy may be an appropriate temporizing measure before delivery of radiation therapy. […] Brachytherapy remains a critical treatment for patients and may shorten treatment time and exposure for some. […] Every effort should be made to ensure timely brachytherapy delivery for patients with gynecologic malignancies, and endocrine therapy may help temporize treatment delays for breast and prostate cancer patients. 2020-05-06
32360053 During this time, several patients requiring assessment and treatment of endodontic emergencies were directed to the School and Hospital of Stomatology at Wuhan University, Wuhan, China. […] Of the total patient visits during this period, 50.26% of visits were for endodontic treatment. […] Vital pulp therapy can advantageously reduce treatment time, resulting in a reduced risk of infection for vital pulp cases. 2020-05-26
32360133 It is unclear whether a more aggressive clinical course might develop in asymptomatic COVID-19 infected subjects during biological therapy and current evidence does not support treatment suspension. […] However, during pandemic, the start of treatment with immunosuppressive drugs and biologics should be postponed whenever possible and based on an individual risk assessment. […] When clinical conditions and the disease activity do not allow a treatment delay, before starting a biological therapy, screening of IBD patients for COVID-19 active infection by RT-PCR should be advisable, even in absence of clinical suspicion. 2020-05-06
32360182 Treatment with IFN-α or IFN-β at a concentration of 50 international units (IU) per milliliter reduces viral titers by 3.4 log or over 4 log, respectively, in Vero cells. […] The EC50 of IFN-α and IFN-β treatment is 1.35 IU/ml and 0.76 IU/ml, respectively, in Vero cells. […] Overall, our results demonstrate the potential efficacy of human Type I IFN in suppressing SARS-CoV-2 infection, a finding which could inform future treatment options for COVID-19. 2020-05-29
32360231 The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) pandemic is a global public health emergency, and new therapeutics are needed. […] It is hoped that knowledge of the potential drug target and mechanism of action of Arbidol will help in the development of new therapeutics for SARS-CoV-2. 2020-05-17
32360238 Palliative care providers play an important role in supporting their patients and family members in these difficult times. 2020-05-17
32360420 Guidelines for the diagnosis and treatment of SARS-CoV-2 infected pneumonia were first published January 30th, 2020; these guidelines recommended for the first time that cytokine monitoring should be applied in severely ill patients to reduce pneumonia related mortality. […] In view of the severe morbidity and mortality of COVID-19 pneumonia, we review the current understanding of treatment of human coronavirus infections from the perspective of a dysregulated cytokine and immune response. 2020-05-13
32360432 Antiretroviral therapy and prophylactic low molecular weight heparin treatment were initiated. […] In COVID-19 patients with prosthetic graft, an aggressive antithrombotic treatment could be considered to prevent such an event. 2020-05-16
32360439 Timely assessment and hyperacute treatment is the key to minimize mortality and morbidity of patients with acute stroke. 2020-05-06
32360479 To analyze the diagnosis and treatment of patients with chronic renal failure complicated with novel coronavirus pneumonia, and to evaluate the effect of blood purification technology on the treatment and prognosis of such patients. […] Two patients received continuous venovenous hemodiafiltration (CVVHDF) every other day for 4-6 h everytime, in addition to the standard treatment. 2020-05-11
32360481 According to the Shiyan experience, early diagnosis with multiple swaps of the Q-PCR test and timely treatment can reduce the death rate. 2020-05-30
32360482 Since nowadays no scientific evidence establishes a correlation between NSAIDS and worsening of COVID-19, patients should be advice against any NSAIDs self-medication when COVID-19 like symptoms are present. 2020-05-30
32360500 Collecting their data and forming a large sample for analysis is more conducive to the recognition, prevention and treatment of coronavirus disease 2019 in children. 2020-05-07
32360578 Patients with locally advanced NSCLC (LA-NSCLC) may require treatment in locations where resources are limited, and the prevalence of infection is high. […] Although guiding data is scarce, we present an expert thoracic oncology multidisciplinary (radiation oncology, medical oncology, surgical oncology) consensus of alternative strategies for the treatment of LA-NSCLC during a pandemic. […] The overarching goals of these approaches are the following: (1) reduce the number of visits to a health care facility, (2) reduce the risk of exposure to severe acute respiratory syndrome-coronavirus-2, (3) attenuate the immunocompromising effects of lung cancer therapies, and (4) provide effective oncologic therapy. […] Nonoperative options include chemotherapy, chemoimmunotherapy, and radiation therapy with sequential schedules that may or may not affect long-term outcomes in an era in which immunotherapy is available. […] Whenever radiation therapy is delivered without concurrent chemotherapy, hypofractionated schedules are appropriate. […] The risk of severe treatment-related morbidity and mortality is increased for patients undergoing treatment for LA-NSCLC during the COVID-19 pandemic. […] Adapting alternative treatment strategies as quickly as possible may save lives and should be implemented through communication with the multidisciplinary cancer team. 2020-05-19
32360580 At present, there is no specific antiviral treatment recommended for SARS-CoV-2 infection. […] The number of virions of SARS-CoV-2 was observed under transmission electron microscope after treatment with LS. […] These findings indicate that LS could inhibit SARS-CoV-2 virus infection via downregulating the expression of inflammatory cytokines induced virus and regulating the activity of NF-κB/MAPK signaling pathway in vitro, making its promising candidate treatment for controlling COVID-19 disease. 2020-05-31
32360583 This meta-analysis aimed at evaluating the efficacy and safety of current option of therapies for severe acute respiratory syndrome (SARS), Middle Eastern respiratory syndrome (MERS) besides COVID-19, in an attempt to identify promising therapy for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infected patients. […] We searched PubMed, EMBASE, Cochrane Library, China National Knowledge Infrastructure (CNKI), China Science and Technology Journal Database (VIP), and WANFANG DATA for randomized controlled trials (RCTs), prospective cohort, and retrospective cohort studies that evaluated therapies (hydroxychloroquine, lopinavir/ritonavir-based therapy, and ribavirin-based therapy, etc.) for SARS, MERS, and COVID-19. […] Compared with control treatment, anti-coronary virus interventions significantly reduced mortality (RR 0.65, 95% CI 0.44-0.96; I2 = 81.3%), remarkably ameliorate clinical improvement (RR 1.52, 95% CI 1.05-2.19) and radiographical improvement (RR 1.62, 95% CI 1.11-2.36, I2 = 11.0 %), without manifesting clear effect on virological eradication, incidence of ARDS, intubation, and AEs. 2020-05-30
32360585 Although many clinical trials are already underway and the majority of patients have received antiviral therapy based on medication experience with severe acute respiratory syndrome (SARS) and Middle East respiratory syndrome (MERS), and preliminary results from some clinical trials, there are no antiviral drugs proven to be effective currently. […] We summarize the current therapeutic medicines used in the clinic, hope to be able to provide some implications for clinical medication. 2020-05-30
32360608 Currently, no vaccine or approved medical treatment is available. 2020-05-19
32360679 The data from all patients who had tested positive for COVID-19 and had presented with ALI requiring urgent operative treatment were collected in a prospectively maintained database. […] Operative treatment was performed in 17 patients (85%). […] The use of prolonged systemic heparin might improve surgical treatment efficacy, limb salvage, and overall survival. 2020-05-15
32360703 COVID-19 requires the collaboration of nearly 200 countries to curb the spread of SARS-CoV-2 while gaining time to explore and improve treatment options especially for cardiovascular disease (CVD) and immunocompromised patients, who appear to be at high-risk to die from cardiopulmonary failure. […] Thus, RAAS inhibitors, which may increase the expression levels of ACE2, are commonly used for the treatment of hypertension and CVD. […] We aim to provide a list of potential treatment options and a better understanding of why CVD is a high risk factor for COVID-19 susceptibility and further discuss the acute as well as long-term cardiac consequences. 2020-05-31
32361161 In this paper, we will systematically review the pathogenic features, transmission routes, and infection mechanisms of SARS-CoV-2, as well as any adverse effects on the digestive system, urogenital system, central nervous system, and circulatory system, in order to provide a theoretical and clinical basis for the diagnosis, classification, treatment, and prognosis assessment of SARS-CoV-2 infection. 2020-05-21
32361325 At 213 confirmed cases under treatment and isolation, a range of interventions were enforced including intensive and expansive contact, mass testing, isolation, and sterilization. 2020-05-27
32361327 Clinical, laboratory, and treatment data were collected and analyzed from 111 hospitalized patients with laboratory-confirmed COVID-19 in Union Hospital. 2020-05-27
32361388 The results showed that people without public health emergency treatment experience showed worse performance in mental health, resilience and social support, and tended to suffer from psychological abnormality on interpersonal sensitivity and photic anxiety. 2020-05-29
32361701 in the reports presented about COVID-19, patients receiving kidney transplantation have not been specifically studied and based on national flowchart, this population is classified as highrisk group, thus it is necessary to be aware of the step-by-step treatment approach of these patients. […] Suspicious cases included patients with a history of dry cough, chills or sore throat accompanying by shortness of breath with or without fever, patients with upper/lower respiratory symptoms with radiological manifestations as single or double-sided multilobular infiltrations on CT scan or plain chest radiography, any one that has a history of close contact with a definite COVID-19 case within the last 14 days, any one with a history of presence in COVID-19 epidemic regions within the last 14 days and patient with pneumonia that despite of proper treatment has an inappropriate clinical response and clinical condition becomes more severe in an unusual way or unexpectedly. 2020-05-06
32361703 He was discharged healthy without development of new pulmonary symptoms despite immunosuppressive treatment. 2020-05-06
32361715 For his experiment Galen used the random allocation of treatment, today’s prospective randomised clinical trial, implemented in the evaluation of novel therapies, widely used internationally, particularly in cancer research! […] COVID-19, caused by the SARS-CoV-2 new corona virus, brought to the fore the randomised trial, as well as, the ethical dilemmas that surround the allocation of treatment at random, in the face of a devastating pandemic. […] Is it his/her right to request the active treatment that a fellow patient is receiving in the next bed? […] Although the Declaration of Helsinki allows the option of no treatment or even placebo, where no known treatment is available for a certain condition, such as COVID-19, it also emphasizes that “while the primary purpose of medical research is to generate new knowledge, this goal can never take precedence over the rights and interests of individual research subjects”. […] In this brief instance of medical history, the equipoise, the scientific imperative, all arguments and other justifications for providing treatment at random, were thrown out of the window in favour of the human factor! […] Because-it is presumed-the process of randomising subjects, protects the study from the selective inclusion of patients with favourable characteristics, thus inadvertently allowing or facilitating a falsely favourable result for the drug or treatment under investigation. […] Since the middle of the 20th century a generation of physicians have been trained to dismiss, or are incapable of evaluating the validity of a treatment beyond the established etiquette of the randomised study. 2020-05-05
32361738 Hypnotics may be an effective ancillary treatment for COVID-19. 2020-05-06
32361744 Remdesivir has received significant attention for its potential application in the treatment of COVID-19, caused by SARS-CoV-2. […] Remdesivir has already been tested for Ebola virus disease treatment and found to have activity against SARS and MERS coronaviruses. 2020-05-06
32361747 Broad-spectrum antimicrobial use is likely to be widespread among hospitalized patients, both as directed and empiric therapy. […] Prospective studies on COVID-19 superinfections are needed, data from which can inform rational antimicrobial treatment and stewardship strategies, and models for market reform and sustainable drug development. 2020-05-06
32361927 Only life-threatening pathologies like periprosthetic fractures and acute septic TJA are currently undergoing surgical treatment. 2020-05-29
32362005 Rapid and effective diagnoses are vital for the isolation of infected people and starting treatment immediately to stop the spread of COVID-19 virus. 2020-05-21
32362061 Therefore, the current data seem to suggest that treatment with dupilumab should not be stopped during COVID-19 pandemic. 2020-05-21
32362134 Aesthetic providers will face new and unique challenges as government stay-at-home orders and related commercial limitations are eased, and the U.S. economy reopens and healthcare systems transition from providing only urgent and other essential treatment to resuming routine care and elective procedures and services. […] In a number of areas, this Guidance Supplement exceeds traditional aesthetic office safety precautions, recognizing reduced tolerance in an elective treatment environment for any risk associated with COVID-19’s highly variable presentation and unpredictable course. 2020-05-04
32362193 Whether asymptomatic patients are contagious or not and whether they need medication are the arguments among clinical experts.Areas covered: This paper reports a special asymptomatic couple with COVID-19, of which the male patient is an intercity bus driver but has not induced confirmed infection of his 188 passengers. […] Their clinical characteristics and medication were summarized and analyzed.Expert opinion: The two asymptomatic patients far away from Wuhan did not seem to be highly contagious. […] They improved obviously, after treatment with the quadruple therapy, but the effective drug is still unknown. 2020-05-14
32362235 Our research group has established that noscapine is a chemotherapeutic agent for the treatment of drug resistant cancers; however, noscapine was also being used as anti-malarial, anti-stroke and cough-suppressant. 2020-05-14
32362245 Currently, several clinical trials are underway to identify specific drugs for the treatment of this novel virus. 2020-05-20
32362296 The diagnosis of COVID-19 was based on positive COVID-19 nucleic acid testing according to the unified triage standards of the Guidelines for the Diagnosis and Treatment of Novel Coronavirus Pneumonia (Trial version 4),4 issued by the National Health Commission of the People’s Republic of China. 2020-05-20
32362299 Treatment with psychotropic medication may sometimes be jeopardised because of the COVID-19 pandemic. 2020-05-28
32362344 Clinical, laboratory, and radiologic results, as well as treatment outcome data, were obtained. […] A total of 70 patients underwent CT imaging repeatedly after treatment. […] High body mass index (OR, 1.285; p = 0.017) and tobacco smoking (OR, 16.13; p = 0.032) were independent risk factors associated with disease exacerbation after treatment. 2020-05-06
32362368 Indeed, while the currently recommended treatment for uncomplicated acute appendicitis is surgical appendectomy, the non-surgical alternative of medical management by antibiotic therapy alone has been widely evaluated by high-quality studies in the literature. […] Insofar as the main limitation of exclusively medical treatment of uncomplicated acute appendicitis is the risk of recurrent appendicitis, this treatment option represents an alternative of choice to reduce the intra-hospital overload in this context of health crisis. […] The aim of this work is therefore to provide physicians and surgeons with a practical guide based on a review of the literature on the medical treatment of uncomplicated acute appendicitis in adults, to offer this alternative treatment to the right patients and under good conditions, especially when access to the operating room is limited or impossible. 2020-05-06
32362392 All cases were mild and successfully recovered after proper treatment. 2020-05-07
32362440 No specific and effective anti-viral treatment has been approved for COVID-19 so far. […] Systemic corticosteroid has been sometimes administered to severe infectious diseases combined with the specific treatment. […] However, as lack of the specific anti-SARS-CoV-2 drug, systemic steroid treatment has not been recommended for COVID-19. […] Rationale of the treatment is to mitigate the local inflammation with inhaled steroid that stays in the lung and to inhibit proliferation of the virus by antiviral activity. 2020-05-20
32362644 Hospitalized adult patients with laboratory-confirmed SARS-CoV-2 infection with any one of the following criteria will be eligible to receive lopinavir/ritonavir for 14 days after obtaining written informed consent: (i) respiratory distress with respiratory rate ≥22/min or SpO2of <94 per cent; (ii) lung parenchymal infiltrates on chest X-ray; (iii) hypotension defined as systolic blood pressure <90 mmHg or need for vasopressor/inotropic medication; (iv) new-onset organ dysfunction; and (v) high-risk groups - age >60 yr, diabetes mellitus, renal failure, chronic lung disease and immunocompromised persons. […] Treatment outcomes amongst initial cases would be useful in providing guidance about the clinical management of patients with COVID-19. 2020-05-06
32362735 Until now there is no effective treatment or drug present to control its life-threatening effects in the humans. 2020-05-07
32362969 The main aim of this systematic review is to provide a comprehensive clinical summary of all the available data from high-quality research articles relevant to the epidemiology, demographics, trends in hospitalization and outcomes, clinical signs and symptoms, diagnostic methods and treatment methods of COVID-19, thus increasing awareness in health care providers. 2020-05-07
32363045 Based on the current epidemic situation, this study reviewed publications on this virus and coronavirus disease 2019 (COVID-19), analyzed common features of respiratory viral pneumonias, and presented the currently reported clinical characteristics of COVID-19 in transplant recipients to improve strategies regarding the diagnosis and treatment of COVID-19 in this special population. 2020-05-07
32363133 This generated a remarkable race to find solutions for the prevention, treatment and management of this disease which is involving a large amount of people. 2020-05-07
32363136 Currently, there is no specific viral protein-targeted therapeutics. 2020-05-14
32363157 The United States Food and Drug Administration has not approved any drug or vaccine for the treatment of COVID-19; however, reports have emerged from different parts of the world about the potential therapeutic benefits of existing drugs. 2020-05-07
32363212 We call for additional randomized controlled trial evidence prior to the widespread incorporation of hydroxychloroquine and chloroquine into national and international treatment guidelines. 2020-05-04
32363219 Re-purposing the available protease inhibitor drugs for immediate use in treatment in SARS-CoV-2 infections could improve the currently available clinical management. 2020-05-07
32363221 A cluster of patients were admitted with unusual pneumonia not responding to treatment in various hospitals. 2020-05-07
32363222 The clinical features and treatment outcomes of twelve paediatric patients confirmed as COVID-19 were analyzed. […] All patients received antiviral and symptomatic treatment and the symptom relieved in 3-4 days after admitted to hospital. 2020-05-07
32363334 We reviewed existing literature surrounding the role of VA-ECMO in the treatment of coronavirus-related cardiovascular collapse. […] The decision to initiate this therapy should take into consideration availability of resources, perceived benefit as well as risks of transmitting disease. 2020-05-07
32363880 Here, we discuss the potential of these therapies for the treatment of coronavirus disease 2019. 2020-05-29
32363963 This is a report of a case with mucous membrane pemphigoid (MMP) with severe eye involvement and concurrent COVID-19 treated successfully using simultaneous high dose intravenous immunoglobulin (IVIg) and anti-viral treatment as hydroxychloroquine, lopinavir/ritonavir, and ribavirin. 2020-05-15
32364011 Given the absence of a current vaccine or specific antiviral treatment, it is urgent to search for FDA-approved drugs that can potentially inhibit essential viral enzymes. […] Although, captopril is shown to be a potential ligand of 3CLpro, it is not recommended anti-COVID-19 therapy, due to the fact that it can induce the expression of the viral cellular receptor such as, angiotensin-converting enzyme ACE-2, and thus, making the patient potentially more susceptible to infection. 2020-05-20
32364028 While healthcare systems need to cope with the need to treat a large number of people with different degrees of respiratory failure, actions to preserve aliquots of the healthcare system to guarantee treatment to patients are mandatory. […] Of these, 47 were hospitalized, 53 needed a differential diagnosis to continue with their cancer treatment, and 201 were about to undergo surgery. 2020-05-04
32364041 So far, however, there no effective treatment has been found to stop this new generation of coronavirus but discovering of the crystal structure of SARS-CoV-2 main protease (SARS-CoV-2 Mpro) may facilitate searching for new therapies for SARS-COV-2. […] The current study provides a powerful in silico results, means for rapid screening of drugs as anti-protease medications and recommend that the above-mentioned drugs can be used in the treatment of SARS-CoV-2 in combined or sole therapy.Communicated by Ramaswamy H. 2020-05-20
32364048 The paper considers the recently published British Medical Association Guidance on ethical issues arising in relation to rationing of treatment during the COVID-19 Pandemic. […] It considers whether it is lawful to create policies for the rationing and withdrawal of treatment, and goes on to consider how such policies might apply in practice. […] Legal analysis is undertaken of certain aspects of the Guidance which appear to misunderstand the law in respect of withdrawing treatment. 2020-05-18
32364119 Research is currently focused on understanding the acute infection and developing effective treatment strategies. 2020-05-10
32364527 Thus, taking control of changes in immune factors could be critical in the treatment of COVID-19. 2020-05-26
32364677 A liver and kidney transplant patient with SARS-CoV-2 pneumonia without respiratory failure was treated in a clinical multimodal strategy consisting of symptomatic support therapy, immunosuppression reduction, use of anti-coronavirus drugs and heparin leading to a progressive improvement of patient symptoms till discharge. 2020-05-26
32365215 Hydroxychloroquine and chloroquine are currently being evaluated as treatment against COVID-19. 2020-05-07
32365415 For patients with severe aortic stenosis, efforts to bring treatment to symptomatic patients amid this pandemic might lead to favored use of catheter based management using minimalist techniques that do not require these elements. 2020-05-04
32365466 Given the lack of registered clinical therapies or vaccines, many physicians and scientists are investigating previously used clinical drugs for COVID-19 treatment. […] Besides, we summarize the recently investigated drugs that constitute an option for COVID-19 treatment. 2020-05-05
32365556 Thus, an immunomodulatory approach targeting the over-production of cytokines could be proposed for viral aggressive pulmonary disease treatment. 2020-05-07
32365891 As this was a current study, there are still not many sources in the literature, and scientific strategies are moving towards therapy and diagnosis, rather than knowing the characteristics of the virus. 2020-05-08
32366025 Overall, our results suggest that the higher divergence observed for the latter three genes could represent a significant barrier in the development of antiviral therapeutics against SARS-CoV-2. 2020-05-07
32366034 Realizing the severity of outcomes associated with this disease and its high rate of transmission, dentists were instructed by regulatory authorities, such as the American Dental Association, to stop providing treatment to dental patients except those who have emergency complaints. […] Dentists at all times should competently follow cross-infection control protocols, but particularly during this critical time, they should do their best to decide on the emergency cases that are indicated for dental treatment. […] This overview will address several issues concerned with the COVID-19 pandemic that directly relate to dental practice in terms of prevention, treatment, and orofacial clinical manifestations. 2020-05-08
32366173 Epistaxis is a common complaint in the general population, and its treatment is a common procedure in emergency departments. 2020-05-05
32366178 With no vaccine or definitive treatment, public health authorities have recommended a strategy of “social distancing,” reducing individual interaction, canceling elective procedures, and limiting nonessential services. […] Health care providers must determine what procedures are considered “elective,” balancing risk of treatment delays with that of coronavirus exposure to patient, family, and providers. 2020-05-05
32366290 The number of severe cases has increased dramatically worldwide, while specific treatment options are scarce. […] In this commentary, we summarize the clinical trials of MSCs treatments on ALI/ARDS and raise MSCs as a hopefully alternative therapy for severe or critical COVID-19. 2020-05-07
32366740 Ibuprofen is an over-the-counter medication that is used widely for the treatment of pain and fever during COVID-19 pandemic. 2020-05-23
32366746 This article summarized the understanding of the etiology, pathogenesis, epidemiology, clinical characteristics, diagnosis, treatment, rehabilitation, and prevention and control measures of COVID-19 based on the available data and anti-epidemic experience in China. 2020-05-05
32366817 Vaccines and targeted therapeutics for treatment of this disease are currently lacking. […] This cross-neutralizing antibody targets a communal epitope on these viruses and may offer potential for prevention and treatment of COVID-19. 2020-05-06
32367170 All patients referred to 4 intensive care units (ICUs) from two centers of a French tertiary hospital for acute respiratory distress syndrome (ARDS) due to COVID-19 between March 3rd and 31st 2020 were included. […] Sixty-four clinically relevant thrombotic complications were diagnosed in 150 patients, mainly pulmonary embolisms (16.7%). 28/29 patients (96.6%) receiving continuous renal replacement therapy experienced circuit clotting. 2020-05-13
32367205 High-dose steroid treatment allowed neurological and respiratory recovery. […] Prompt invasive treatment should be adopted to avoid hypoxic neurotoxicity and prevent CNS injuries. 2020-05-08
32367683 Apart from being an infectious disease, it may affect human behavior and healthcare resource allocation which potentially cause treatment delay in MI. 2020-05-05
32367812 He developed respiratory failure and was transferred to the intensive care unit where he received further treatment, including tocilizumab (IL-6 receptor inhibitor). 2020-05-06
32367847 In rapid systematic review, we found studies showing some improvement in prevention and treatment of upper respiratory tract infections. 2020-05-05
32367852 Currently, no effective therapy or vaccine is available to manage this illness. 2020-05-05
32367888 CONCLUSIONS The dynamic changes of CT images of lungs of COVID-19 patients, combined with the clinical manifestations and laboratory indicators of patients, can help guide clinical diagnosis and treatment. 2020-05-06
32368252 In this scenario, neoadjuvant endocrine treatment could be an appropriate alternative treatment for hormone receptor positive breast cancer (luminal-like tumours) in order to minimise hospital admissions and to delay elective surgeries. 2020-05-08
32368429 Radiation therapy is another essential clinical service that cannot afford to suffer prolonged delays without compromising patient outcomes. […] Early action and guidance are therefore critical to minimize transmission events and ensure safe and timely delivery of radiation therapy. […] The purpose of this report is to describe the institutional patient experience and quantify the impact of treatment delays and interruptions over the first month of the COVID-19 outbreak. 2020-05-08
32368550 On day 9 after conservative treatment, her condition was alleviated. 2020-05-08
32368570 The present study review is on the general continent, virology, pathogenesis, global epidemiology, clinical presentation, diagnosis, treatment and control of COVID-19 with the reference to India. 2020-05-07
32368712 To address this racial disparity, we must apply a health equity lens and disaggregate data explicitly for African Americans, as well as other populations at risk for biased treatment in the health-care system. 2020-05-07
32368875 There is no publication involving protection measures for diagnostic and therapeutic procedures in nuclear medicine (NM) (appointment, patient acceptance, imaging and treatment procedures, disinfection etc). […] In cancer cases requiring urgent treatment, radionuclide treatment (RNT) should be planned according to the COVID-19 test result. 2020-05-14
32368884 The management of mild cases of confirmed infection is another point of controversy, as drugs which may be repurposed for COVID-19 treatment have significant, potentially irreversible toxic effects and their use in mild cases of a viral illness which is typically self-limited may be harmful. 2020-05-07
32368894 At 85 °C, 30% RH, we were able to perform 50 cycles of heat treatment without significant changes in the filtration efficiency. […] At low humidity or dry conditions, temperatures up to 100 °C were not found to alter the filtration efficiency significantly within 20 cycles of treatment. […] Ultraviolet (UV) irradiation was a secondary choice, which was able to withstand 10 cycles of treatment and showed small degradation by 20 cycles. 2020-05-29
32369030 Third, guidelines for rehabilitation (physiotherapy, occupational therapy, speech-language pathology) following COVID-19 have been proposed with respect to recovery of the respiratory system as well as recovery of mobility and function. […] A thorough assessment and an individualized, progressive treatment plan which focuses on function, disability, and return to participation in society will help each patient to maximize their function and quality of life. 2020-05-21
32369097 There have been recommendations to discontinue these medications, which are essential in the treatment of several chronic disease conditions, while, in the absence of clinical evidence, professional societies have advocated their continued use. […] However, further study in larger numbers of hospitalized patients receiving ACEI and ARB therapy is needed to determine the association with clinical measures of COVID-19 severity. 2020-05-14
32369191 However, it is not possible to ascertain which adverse events were directly related to tocilizumab therapy. 2020-05-11
32369192 The reasons for the consults are mostly familiar-surrogate decision-making, informed refusal of treatment, goals of care, defining futility. 2020-05-05
32369205 A total of 344 patients with mild COVID-19 were included in the final analysis, 45 of whom progressed and needed high-flow oxygen therapy or mechanical ventilation after admission. 2020-05-18
32369208 On the basis of antiviral drugs, antibiotics treatment, appropriate dosage of corticosteroid and gamma globulin therapy significantly improve patients’ outcomes. […] Early identification and timely medical treatment are important to reduce the severity of patients with COVID-19. 2020-05-05
32369222 The management of COVID-19 patients includes epidemiological risk and patient isolation; treatment entails general supportive care, respiratory support, symptomatic treatment, nutritional support, psychological intervention, etc. 2020-05-23
32369429 Increased awareness of this fact may encourage earlier diagnosis and treatment, as well as heighten vigilance for viral transmission. 2020-05-05
32369431 With our skill set, otolaryngologists are poised to support various aspects of hospital wards, intensive care units, emergency departments, and beyond. 2020-05-05
32369433 Respiratory therapists, intensivists, nursing leadership and the palliative care interdisciplinary team participated in focus groups. […] Key informant interviews were conducted with emergency management, respiratory therapy and emergency medicine. 2020-05-05
32369601 In this consensus statement, an international group of experts present mitigation strategies and treatment guidance for patients suffering from high grade gliomas (HGG) during the coronavirus disease 2019 (COVID-19) pandemic. 16 international experts in the treatment of HGG contributed to this consensus-based practice recommendation including neuro-oncologists, neurosurgeons, radiation -oncologists and a medical physicist. […] Generally, treatment of neuro-oncological patients cannot be significantly delayed and initiating therapy should not be outweighed by COVID-19. […] We present detailed interdisciplinary treatment strategies for molecular subgroups in two pandemic scenarios, a scale-up phase and a crisis phase. […] This practice recommendation presents a pragmatic framework and consensus-based mitigation strategies for the treatment of HGG patients during the SARS-CoV-2 pandemic. 2020-05-29
32369624 Liver transplantation (LT) centers should adapt to the pandemic by considering leniency to some LT candidates with ALD who cannot access appropriate alcohol treatment due to the current situation. 2020-05-09
32370561 Without the ability to efficiently screen patients, hospitals are overwhelmed, potentially delaying treatment for other emergencies. […] Early screening and triage is achievable from the outset of a pandemic with point-of-care host immune response testing which will improve response time to clinical and public health actions.Key messagesDelayed testing deployment has led to uncertainty surrounding overall disease burden and community spread, severely hampering public health containment and healthcare system preparation efforts.A multi-tiered testing strategy incorporating rapid, host immune point-of-care tests can be used now and for future pandemic planning by effectively identifying patients at risk of disease thereby facilitating quarantine earlier in the progression of the outbreak during the weeks and months it can take for pathogen specific confirmatory tests to be developed, validated and manufactured in sufficient quantities.The ability to triage patients at the point of care and support the guidance of medical and therapeutic decisions, for viral isolation or confirmatory testing or for appropriate treatment of COVID-19 and/or bacterial infections, is a critical component to our national pandemic response and there is an urgent need to implement the proposed strategy to combat the current outbreak. 2020-05-21
32370758 An accurate evaluation of RdRps from different viruses may guide the development of new drugs or the repositioning of already approved antiviral drugs as treatment of SARS-CoV-2. 2020-05-11
32370766 To date, there is no specific anti-COVID-19 treatment. 2020-05-07
32370981 We conducted a national online survey to assess the evolution of electroconvulsive therapy (ECT) in the different centres practicing this treatment. 65 responses from all over France were analysed. 2020-05-08
32370982 There are also major issues when referring patients with acute mental disorders to intensive care units. 2020-05-08
32370984 In France, this large-scale health crisis urgently triggered the restructuring and reorganization of health service delivery to support emergency services, medical intensive care units and continuing care units. 2020-05-08
32370986 Since the ACE2 (angiotensin-converting enzyme 2) enzyme is the receptor that allows SARS COV2 entry into cells, the fear was that pre-existing treatment with ACEi or ARB might increase the risk of developing severe or fatal severe acute respiratory syndrome in case of COVID-19 infection. 2020-05-08
32371027 Consensus on Science and Treatment recommendations aim to balance the benefits of early resuscitation with the potential for harm to care providers during the COVID-19 pandemic. 2020-05-20
32371416 Following treatment with oseltamivir and short-term methylprednisolone combined with symptomatic management, all three patients recovered within 3 weeks, as evidenced by the disappearance of their symptoms, clearance of pulmonary infiltrates and consecutive negative molecular diagnostic test findings. […] Our observations suggest the importance of preventing family transmission and the efficacy of current integrated treatment for mild/moderate pneumonia in COVID-19 cases. 2020-05-07
32371479 Early reports suggest that tocilizumab, an IL6 receptor-blocking antibody used to manage toxicities associated with chimeric antigen receptor T-cell therapy, may help control cytokine storms in people infected with COVID-19. 2020-05-06
32371555 ECMO is a resource-intensive therapy that can be considered in highly selected patients. […] Expert centers should employ an evidence-based ARDS treatment algorithm and a multidisciplinary approach to recommending ECMO upon failure of conventional therapy. 2020-05-06
32371557 The mechanism of SARS-CoV-2 and associated myocardial injury, whether SARS-CoV-2 patients with myocardial injury are a distinct population, and possible treatment options for myocardial injury associated with SARS-CoV-2 are unknown. 2020-05-06
32371558 Data on HCQ for treatment of coronavirus disease 2019 (COVID-19) are rapidly evolving. […] To date there is no evidence from randomized controlled trials that any single therapy improves outcomes in patients infected with COVID-19. […] There are also no clinical trial data supporting prophylactic HCQ therapy in COVID-19. […] Hydroxychloroquine (HCQ) use in patients with COVID-19 is being investigated examining prophylaxis, postexposure prophylaxis, and treatment regimens. 2020-05-06
32371560 Positive airway pressure (PAP) therapy is an open system that can generate contact, droplet, and airborne COVID-19 thereby increasing the risk of transmission of COVID-19 like other procedures such as tracheal intubation, noninvasive ventilation, and cardiopulmonary resuscitation. […] Medically prudent recommendations have been established for home use of PAP therapy in asymptomatic patients and patients with suspected or confirmed COVID-19. 2020-05-06
32371562 Based on expert opinion, strategies for outpatient management include use of elexacaftor-tezacaftor-ivacaftor to reduce pulmonary exacerbations, telemedicine, adherence to prescribed regimens, prompt and aggressive treatment of CF exacerbations, and communication about COVID-19 with patients with CF. 2020-05-06
32371563 During this pandemic, it is recommended that patients with asthma continue taking all controller inhalers and other asthma medication as prescribed to prevent exacerbations and limit outpatient clinic and emergency room exposure. 2020-05-06
32371624 The complications from COVID-19 can be reduced by (1) delivering interdisciplinary rehabilitation that is initiated early and continued throughout the acute hospital stay, (2) providing patient/family education for self-care after discharge from inpatient rehabilitation at either acute or subacute settings, and (3) continuing rehabilitation care in the outpatient setting, and at home through ongoing therapy either in-person or via telehealth. 2020-05-06
32372573 As the global prevalence of diabetes continues to increase, patients with endocrine diseases such as diabetes mellitus and those who are on long-term corticosteroid therapy due to adrenal insufficiency or hypopituitarism are at risk for a poor prognosis of COVID-19. 2020-05-06
32372695 More than 2,000,000 individuals worldwide have had coronavirus 2019 disease infection (COVID-19), yet there is no effective medical therapy. […] Multiple off-label and investigational drugs, such as chloroquine and hydroxychloroquine, have gained broad interest due to positive pre-clinical data and are currently used for treatment of COVID-19. […] Many antibiotics commonly used for the treatment of patients with COVID-19, for instance azithromycin, can also prolong QT interval. […] This review summarizes evidenced-based data regarding potential cardiac adverse effects due to off-label and investigational drugs including chloroquine and hydroxychloroquine, antiviral therapy, monoclonal antibodies, as well as common antibiotics used for the treatment of COVID-19. 2020-05-29
32372821 The covid-19 pandemic has encouraged more people to make advance treatment decisions relating to CPR and ventilation, reports Clare Wilson. 2020-05-06
32373183 Chloroquine and closely related structural analogs, employed initially for the treatment of malaria, are now gaining worldwide attention due to the rapidly spreading pandemic caused by severe acute respiratory syndrome-coronavirus-2, named coronavirus disease (COVID) of 2019 (COVID-19). […] This review aims to present the available in vitro and clinical data for the role of chloroquine/hydroxychloroquine in COVID-19 and attempts to put them into perspective, especially in relation to the different risks/benefits particular to each patient who may require treatment. 2020-05-20
32373461 The current Opinion Paper is one of the first attempts, to my understanding, to summarize and integrate environmental and human health aspects related to the monitoring, fate and treatment solutions for COVID-19. 2020-05-08
32373721 Low dose radiotherapy (0,5 Gy), is an evidence-based anti-inflammatory treatment, that could modify the immune landscape in the lung affected of SARS-CoV-2 pneumonia, through macrophages polarization to alternatively activated Macrophages (M2 phenotype). […] LDRT is a cost-effective non-toxic treatment already available in most general hospitals. 2020-05-08
32373992 SARS-Cov-2 has a strong infection, and the mortality rate of severe patients after infection is high, but there is no effective treatment. […] In this short report, combined with the progress of preclinical and clinical research, we comment the efficacy of MSCs in the treatment of COVID-19. 2020-05-08
32373993 The aim of this study was to indirectly investigate the efficacy of chloroquine and hydroxychloroquine for the treatment of COVID-19 by determining the prevalence of COVID-19 in malaria pandemic and non-pandemic nations. […] We sought evidence to support or refute the hypothesis that these drugs could show efficacy in the treatment of COVID-19. […] The studies on "COVID-19 and its allied treatment were found from World Health Organization (WHO), ISI-Web of Science, PubMed, EMBASE, Scopus, Google Scholar, and clinical trial registries. […] The search was based on keywords: antiviral drugs, chloroquine, hydroxychloroquine, COVID-19, COVID-19 treatment modalities, and coronavirus. […] The findings support the hypothesis that these drugs have efficacy in the treatment of COVID-19. 2020-05-08
32373997 There are currently no effective antiviral drugs treatment for the affected children. […] No sufficient results have been reached by the use of interferon (IFN), lopinavir/ritonavir, orbidol, and oseltamivir in the treatment of the coronaviruses infection. 2020-05-08
32373998 Meanwhile, we analyzed the epidemiologic and clinical characteristics of COVID-19, in order to provide recommendations for present clinical treatments and inspirations for potential therapy options. 2020-05-08
32373999 Current researches on potentially effective treatment alternatives are discussed. 2020-05-08
32374000 Due to the high mortality rate and the lack of optimum therapeutics, it is crucial to understand the biological characteristics of the virus and its possible pathogenesis to respond to the SARS-CoV-2. […] Rapid diagnostics and effective therapeutics are also important interventions for the management of infection control. […] However, the rapid evolution of SARS-CoV-2 exerted tremendous challenges on its diagnostics and therapeutics. […] In this review, we focus on our current understanding of epidemiology, pathogenesis, diagnostics and therapeutics of coronavirus disease 2019 (COVID-19). 2020-05-08
32374001 We highlighted the role of HLA haplotype in virus infection as HLA typing will provide susceptibility information for personalized prevention, diagnosis, and treatment in future studies. 2020-05-08
32374007 Chinese Clinical Guidance for COVID-19 Pneumonia Diagnosis and Treatment (7th edition) by National Health Commission is recommended to follow as it provides detailed diagnostic procedures using currently available tools. 2020-05-08
32374026 Nor is there sufficient evidence base to conclude that alternative approaches to treatment are incorrect. 2020-05-06
32374074 The main protease (Mpro , also called 3-chymotrypsin-like protease) of SARS-CoV-2 is a potential target for treatment of COVID-19. 2020-05-29
32374264 These examples also reveal the unlimited opportunity to future-proof our health care systems by proactively mining, synthesizing, cataloging, and evaluating the off-label treatment opportunities of thousands of safe, well-established, and affordable generic drugs. 2020-05-26
32374440 Members of the AGS Ethics Committee collaborated with interprofessional experts in ethics, law, nursing, and medicine (including geriatrics, palliative care, emergency medicine, and pulmonology/critical care) to conduct a structured literature review and examine relevant reports. 2020-05-14
32374474 Outbreaks of infections with viruses like Sars-CoV-2, Ebola virus and Zika virus lead to major global health and economic problems because of limited treatment options. 2020-05-06
32374538 Diagnosis is based on PCR from a nasopharyngeal swab and emergency treatment rely on oxygen therapy. 2020-05-08
32374541 Antidiabetic therapy may need adjustments following usual sick day rules. […] Insulin therapy should be considered to treat any persistent hyperglycemia in patients hospitalized for an acute infection. 2020-05-08
32374806 The authors propose psychological interventions for prevention and treatment in order to mitigate the pandemic’s psychological impacts. 2020-05-11
32374823 Prevotella may have role in COVID-2019 outbreak and should be given importance for understanding disease mechanisms and improving treatment outcomes. 2020-05-06
32375011 This article critically appraises the opportunities and challenges exergames present for the prevention and treatment of anxiety disorders in a home-based environment during the COVID-19 quarantine period. 2020-05-06
32375025 Because of the vital role that these S proteins play, they represent a vulnerable target for the development of therapeutics. […] These data provide a molecular basis for the neutralization of pathogenic betacoronaviruses by VHHs and suggest that these molecules may serve as useful therapeutics during coronavirus outbreaks. 2020-05-29
32375085 Diverse clinical manifestations and laboratory abnormalities occur in patients with cardiovascular injury in COVID-19, characterizing the development of this complication, as well as providing clues to diagnosis and treatment. 2020-05-08
32375144 The COVID-19 pandemic has stressed patients and healthcare givers alike and challenged our practice of antenatal care, including fetal diagnosis and therapy. 2020-05-06
32375200 Here we present a series of five cases of severe pneumomediastinum requiring decompression therapy over a 7-day period in the current COVID-19 outbreak. 2020-05-06
32375268 In this context, novel approaches in both gene therapy and vaccine development are essential. 2020-05-07
32375446 In order to achieve the overall victory over 2019 novel coronavirus disease epidemic, especially to prevent the disease recurrence from rebounding during the resumption of labor, the government has not loosened any control of personnel mobility, which has obviously affected the normal examination and treatment of lung cancer patients under the influence of this epidemic. […] It is necessary to provide more appropriate individualized treatment recommendations for patients with lung cancer based on the epidemic situation of the patient’s location and in combination with the patient’s own condition. […] Through active prevention of infection, timely conversion of treatment strategies, online and offline joint control, and positive psychological counseling, we do our best to help patients with lung cancer to survive this difficult period. 2020-05-11
32375487 This paper describes, besides general measures in times of a pandemic, also the necessary changes in the invasive diagnosis and treatment of patients presenting with different entities of acute coronary syndromes including structural adaptations (networks, spokes and hub centres) and therapeutic adjustments. 2020-05-29
32375488 There has been increasing sharing experience regarding the patient’s clinical features over the last weeks which has underlined the need for general guidance on treatment strategies. 2020-05-29
32375564 The only resource is people themselves using self-help, self-medication and self-care. 2020-05-07
32375574 The reemergence of coronavirus prompts the need for the development of effective therapeutics to prevent the cellular entry and replication of coronavirus. 2020-05-20
32375845 Thus, fully understanding the characteristics of COVID-19-related ARDS is conducive to early identification and precise treatment. 2020-05-11
32375887 The impact of COVID-19 across health services, including treatment services for people who use drugs, is emerging but likely to have a high impact. […] Treatment services for people who use drugs provide essential treatment services including opiate agonist treatment and needle syringe programmes alongside other important treatment programmes across all substance types including withdrawal and counselling services. […] Ensuring ongoing supply of opiate treatment during these periods will require significant changes to how treatment is provided. […] Ensuring people who use drugs have access to drug treatment as well as access to screening and testing for SARS-CoV2 where this is indicated is important. 2020-05-11
32376004 If there is no curative treatment for infection to SARS-CoV-2, the interactions of the various molecules currently tested with several classes of psychotropic drugs (antidepressants, antipsychotics) are important to consider because of the risk of changes in cardiac conduction. 2020-05-09
32376099 Given their equal efficacy but fewer adverse events, ARBs could potentially be a more favorable treatment option in patients with COVID-19 at higher risk for severe forms of disease. 2020-05-09
32376170 The rapid surge of patients presenting over a small period for emergent clinical care, admission to the hospital, and intensive care units with many requiring mechanically assisted ventilators for respiratory support demonstrated the potential to overwhelm health care workers, hospitals, and health care systems. 2020-05-09
32376263 Family members of patients admitted to the acute palliative care unit and hospice were screened for a period of two weeks. 2020-05-22
32376346 For this reason, the Government of Lombardy decided to centralize the treatment of ACS patients in a limited number of centers, including our university cardiology institute, which in the past 4 weeks became a cardiovascular emergency referral center in a regional hub-and-spoke system. 2020-05-09
32376394 Furthermore, we must keep in mind that currently, no specific antiviral treatment is available for SARS-CoV-2. […] While moderate-severe forms need in-hospital surveillance plus antivirals and/or hydroxychloroquine; in severe and life-threating subsets a high intensity anti-inflammatory and immunomodulatory therapy could be a therapeutic option. 2020-05-29
32376397 Severe patients are hospitalized and the treatment is done, though they have not been established yet. […] Currently, however, no treatment is provided for those who are isolated at home or shelter until they get severe symptoms, which will increase the harms to the patients. 2020-05-30
32376402 As no specific therapeutics are yet available to control disease evolution, more in-depth understanding of the pathogenic mechanisms induced by SARS-CoV-2 will help to characterize new targets for the management of COVID-19. 2020-05-29
32376531 It is therefore essential to provide timely treatment opinions and prevention methods for common skin problems. 2020-05-08
32376532 The control measures to contain the epidemic also produced influences on the transport and treatment process of patients with acute myocardial infarction (AMI), and adjustments in the management of the patients need to be made at this particular time. […] AMI is characterized by an acute onset with potentially fatal consequence, a short optimal treatment window, and frequent complications including respiratory infections and respiratory and circulatory failure, for which active on-site treatment is essential. […] To standardize the management and facilitate the diagnosis and treatment, we formulated the guidelines for the procedures and strategies for the diagnosis and treatment of AMI, which highlight 5 Key Principles, namely Nearby treatment, Safety protection, Priority of thrombolysis, Transport to designated hospitals, and Remote consultation. […] For AMI patients, different treatment strategies are selected based on the screening results of SARS-CoV-2, the time window of STEMI onset, and the vital signs of the patients. […] In the transport and treatment of AMI patients, the physicians should strictly observe the indications for patient transport with appropriate protective measurements of the medical staff. 2020-05-08
32376546 The selection of appropriate detection techniques and methods for accurate and rapid identification of pathogens therefore plays a key role in improving the diagnosis and treatment of the patients and containing the outbreak. 2020-05-08
32376573 According to the Fifth Edition of the Diagnosis and Treatment Guidelines by the National Health Commission, the patients were divided into common type, severe type and critical type. […] MSCT volume scanning not only allows early diagnosis of COVID-19 but also provides evidence for evaluating the severity of COVID-19 to assist in the clinical treatment of the patients. 2020-05-11
32376583 We review the experience with the diagnosis and treatment of secondary cerebral infarction in an elderly patient with coronavirus disease 2019 (COVID-19). […] Early anti-infection therapy, immune regulation and appropriate anticoagulation intervention may help improve the prognosis of the patients. 2020-05-11
32376587 RCTs provides the gold standard for evaluating the effectiveness of a given treatment for the patients from the outbreaks. 2020-05-11
32376588 Under the instructions by the E’zhou Medical Team Front Command, the staff made quick responses to the surging number of patients with COVID-19 and rapidly formulated treatment plans based on the local conditions. 2020-05-11
32376592 Twelve patients were still on endotracheal mechanical ventilation in the intensive care unit, and one of them received ECMO treatment due to poor oxygenation. […] For patients with severe and critical COVID-19 and indications of tracheal intubation, we recommend early intubation with invasive respiratory support to improve the treatment efficacy and reduce the mortality. 2020-05-11
32376627 The coronavirus disease COVID-19, caused by emerging SARS-CoV-2, has posed serious threats to global public health, economic and social stabilities, calling for the prompt development of therapeutics and prophylactics. 2020-05-07
32376714 The fundamental role of the spike protein in infectivity suggests that it is an important target for vaccine development, blocking therapy with antibodies and diagnostic antigen-based tests. 2020-05-07
32377176 Pancreatic cancer is a very aggressive disease and survival remains dismal even with treatment. […] Although we have general strategies available from experience in Italy, we need more treatment specific strategies to help mitigate risks of complications and toxicities from chemotherapy in order to protect our patients from COVID-19 as much as possible. 2020-05-13
32377375 Identification of novel BCR signaling may lead to the development of vaccines and antibodies for the treatment of COVID-19. 2020-05-09
32377468 Her RT-PCR test was negative after five days of treatment, suggesting that children can clear the virus faster than adults. […] These findings serve as a practical reference for the clinical diagnosis and medical treatment of children with COVID-19. 2020-05-09
32377486 Although the chief focus is on minimizing transmission through prevention, combating infection, and saving lives by ramping up the development of treatment and vaccines, very little attention is on the critical issue of physician burnout, resident burnout, and the psychological well-being of HCW. 2020-05-09
32377559 An expert US committee developed the US NIH guidelines for COVID-19 treatment, which was just released and will be regularly updated. 2020-05-09
32377596 This study reviews the impact of COVID-19 on a hospital system in New York on aspects of medicine, nursing, radiation therapy, and administration.Materials/Methods: A retrospective review was conducted of the department of radiation oncology in a single health system in New York from 3/1/20 to 4/1/20. […] Collaboration was obtained from physicians, nursing, radiation therapy, and administration to recall their policies and impact on specific duties. […] Numbers were obtained for patients on treatment, treatments breaks, and COVID-19 infections amongst staff and patients. […] Radiation Oncology made aggressive efforts to reduce patients on treatment to protect patients and staff as well reallocate staff and space for more acute clinical needs. 2020-05-07
32377638 Moreover, additional clinical data are needed in order to determine whether a supportive therapy can help mitigate the development of severe, potentially fatal complications, and further studies are needed to identify the pathophysiology and the mechanism underlying this novel coronavirus-associated infectious disease. 2020-05-09
32377677 We searched PubMed and bioRxiv/medRxiv to identify English language papers describing the testing, treatment and prognosis of COVID-19. […] Screening of over 1100 peer-reviewed and pre-print papers yielded n = 22 on COVID-19 testing, n = 15 on treatment and n = 13 on prognosis. 2020-05-29
32378314 Despite reduction in immunosuppression and treatment with tocilizumab, intravenous immunoglobulin, hydroxychloroquine, lopinavir/ritonavir, and broad-spectrum antibiotics, she ultimately died from multiorgan failure. 2020-05-22
32378459 Application of nanobiotechnology could represent a new avenue for the treatment or disinfection of viruses. 2020-05-07
32378471 Current clinical treatment at hand is inadequate to suppress viral replication and inflammation, and reverse organ failure. […] Intensive research efforts have focused on increasing our understanding of viral biology of SARS-CoV-2, improving antiviral therapy and vaccination strategies. […] We will discuss the benefits and caveats of these animal models and present critical findings that might guide the fundamental studies and urgent treatment of SARS-CoV-2-caused diseases. 2020-05-15
32378647 Interleukin 6 (IL-6) inhibitor (tocilizumab) had been suggested for the treatment of acute respiratory distress syndrome (ARDS) patients based on the concept of “cytokine storm” in COVID-19. […] The efficacy of IL-6 monoclonal antibody-directed therapy remains to be fully evaluated. 2020-05-08
32378729 More importantly, a compre-hensive understanding of pathological mechanisms of COVID-19 will increase the efficacy of therapy and decrease mortality. 2020-05-29
32378737 Combination therapy should be evaluated in vitro. […] Re-purposing drugs for use in COVID-19 treatment is an ideal strategy but is only feasible when product safety has been established and experiments of re-purposed drugs are conducted at clinically relevant concentrations. 2020-05-07
32378801 In this article, we compared SARS-CoV-2 with SARS-CoV and influenza virus, discussed current researching progress of COVID-19, including clinical characteristics, pathological changes, treatment measures, and so on. 2020-05-22
32378805 There have already been examples of self-medication and overdose. 2020-05-13
32378844 A total of nine patients (21 %) had a critical course of illness with treatment in the Intensive Care Department and/or death during their stay in hospital. 2020-05-12
32378854 Together, these findings may inform future research, diagnosis, prevention and treatment of COVID-19. 2020-05-12
32379056 We prefer a simple and convenient treatment regimen, which may also be postponed appropriately. […] In total, adequate doctor-patient communication is also recommended throughout the treatment. 2020-05-26
32379057 During this period, our infection and orthopedic treatment unit in the center of the epidemic area effectively treated 82 elderly patients with hip fracture, and no cross-infection occurred. […] Therefore, our experience in prevention and treatment is worth recommending to frontline anti-epidemic personnel. 2020-05-26
32379114 Analyses of early prognosis were based on clinical outcomes and trends in laboratory results during treatment. […] Surgical treatment should be carried out cautiously or nonoperative care should be chosen for patients with fracture in COVID-19-affected areas, especially older individuals with intertrochanteric fractures. 2020-05-20
32379199 However, our understanding of the clinical characteristics and treatment of critically ill pediatric patients and their ability of transmitting the coronavirus that causes COVID-19 still remains inadequate because only a handful pediatric cases of COVID-19 have been reported. […] Epidemiology, clinical characteristics, treatment, laboratory data and follow-up information and the treatment of critically ill infant were recorded. 2020-05-08
32379346 In the present comment the treatment of COVID19 patients with ACE2 activators, such as diminazene aceturate (DIZE), which are currently used as antiparasitic drugs, is proposed. 2020-05-18
32379639 This review aimed to summarize and analyze the pattern identification (PI), herbal formulae, and composition of herbs provided by recent guidelines for the treatment of pediatric COVID-19. […] This review serves as a reference for the use of traditional medicine in the treatment of pediatric COVID-19. 2020-05-11
32379667 Patients with Coronavirus Disease 2019(COVID-19) will experience high levels of anxiety and low sleep quality due to isolation treatment. […] During this period, the control group received only routine care and treatment. 2020-05-11
32379692 No effective treatment for this disease was verified, so the morbidity and mortality rate were supposed higher than flu. 2020-05-11
32380026 Instead of redeploying pediatric providers to work with internist-led teams throughout a medical center, pediatric physicians and nurses organized and staffed a 40-bed adult COVID-19 treatment unit within a children’s hospital. 2020-05-23
32380051 The outbreak of emerging infectious pneumonia caused by 2019 Novel Coronavirus (2019-nCoV) has posed an enormous threat to public health, and traditional Chinese medicine (TCM) have made vast contribution to the prevention, treatment and rehabilitation of coronavirus disease 19 (COVID-19) among Chinese population. […] Given this, based on the Guideline on Diagnosis and Treatment of Coronavirus Disease 2019 in China, the present review summarized the basic information, clinical evidence and published literatures of recommended CPMs against COVID-19. […] The details were thoroughly introduced involving compositions, therapeutic effects, clinical indications, medication history of CPMs and the profiles of corresponding research. 2020-05-30
32380200 The antiviral peptides can prevent SARS-CoV-2 membrane fusion and can potentially be used for the prevention and treatment of infections. 2020-05-09
32380210 For the N gene and ORF1ab gene, the CT values of 4 inactivated and Non-inactivated treatment were correlated (P<0.001). […] The results of the four treatment methods and specimens without inactivated treatment have shown good consistency. […] The treatment of nasopharyngeal swab specimens using mentioned four inactivated methods had no significant effect on the subsequent detection of the new COVID-19 nucleic acid test. 2020-05-31
32380315 A comparison was conducted between subjects tested positive for SARS-CoV-2 and those found negative in terms of rate of administration of hydroxychloroquine/colchicine therapy. 2020-05-23
32380453 There has so far been no evidence from randomized controlled trials to prescribe any particular anti-nCoV treatment or vaccine, and COVID-19 management has been widely supportive. 2020-05-20
32380474 • The main complication of desmopressin treatment in DI is dilutional hyponatraemia. 2020-05-08
32380475 • Clinical evaluation should guide those needing investigation • Strict adherence to COVID-19 protection measures is necessary • Alternative ways of consultations (telephone, video) should be used • Early discussion with regional/national experts about investigation and management of potential and existing patients is strongly encouraged • Patients with moderate and severe clinical features need urgent investigation and management • Patients with active Cushing’s syndrome, especially when severe, are immunocompromised and social shielding is recommended • In patients with mild features or in whom a diagnosis is less likely, clinical re-evaluation should be repeated at three and six months or deferred until the prevalence of SARS-CoV-2 has significantly decreased • Diagnostic pathways may need to be very different from usual recommendations in order to reduce investigations • When extensive differential diagnostic testing is not feasible, it should be deferred, and medical treatment should be initiated • Transsphenoidal pituitary surgery may be avoided during high SARS-CoV-2 viral prevalence • Medical management rather than surgery will be the used for most patients since the short- to mid-term prognosis depends in most cases on hypercortisolism rather than its cause; it should be initiated promptly to minimize the risk of infection in these immunosuppressed patients. 2020-05-08
32380511 The mouse model with SARS-CoV-2 infection will be valuable for evaluating antiviral therapeutics and vaccines as well as understanding the pathogenesis of COVID-19. 2020-05-07
32380582 The actual sanitary crisis led to a massive mobilization of the sanitary system toward intensive care units and management of coronavirus disease 2019 (COVID-19) patients. 2020-05-08
32380891 We explore here the impact of this unique crisis on victims of elder mistreatment and people at risk of victimization. […] The COVID-19 outbreak has also had a profound impact on the organizations from many sectors that typically respond to protect and serve victims of elder mistreatment. 2020-05-23
32380903 These findings will be of significant use in guiding the development of serologic tests, formulating convalescent plasma therapy strategies, and assessing the longevity of protective immunity for SARS-related coronaviruses in general as well as vaccine efficacy. 2020-05-11
32380908 This prospective nonrandomized open-label cohort study addresses the safety and efficacy of exosomes (ExoFlo™) derived from allogeneic bone marrow mesenchymal stem cells as treatment for severe COVID-19. […] Patients received a single 15 mL intravenous dose of ExoFlo and were evaluated for both safety and efficacy from days 1 to 14 post-treatment. […] In total, 17 of 24 (71%) patients recovered, 3 of 24 (13%) patients remained critically ill though stable, and 4 of 24 (16%) patients expired for reasons unrelated to the treatment. […] Overall, after one treatment, patients’ clinical status and oxygenation improved with an average pressure of arterial oxygen to fraction of inspired oxygen ratio (PaO2/FiO2) increase of 192% (P < 0.001). 2020-05-23
32381073 The chest computed tomography (CT) revealed scattered ground glass opacities in the right lower lobe close to the pleura and resorption after the treatment. 2020-05-12
32381264 We recently reported a high cumulative incidence of thrombotic complications in critically ill patients with COVID-19 admitted to the intensive care units (ICUs) of three Dutch hospitals. […] In the competing risk model, chronic anticoagulation therapy at admission was associated with a lower risk of the composite outcome (Hazard Ratio [HR] 0.29, 95%CI 0.091-0.92). 2020-05-11
32381426 The reasons for hospitalization were: surgical treatment of cancer (n=5), complex emergencies (n=5), treatment of complications linked to cancer or its treatment (n=3), gastroplasty (n=1), and stoma closure (n=1). 2020-05-11
32382072 Carmofur inhibits viral replication in cells (EC50 = 24.30 μM) and is a promising lead compound to develop new antiviral treatment for COVID-19. 2020-05-08
32382873 Currently, there is still no licensed specific antiviral treatment for the human coronavirus disease and a vaccine will not be ready soon. […] However, based on experience from the use of other antiviral agents to treat similar virusses, some treatment options have been tried with some efficacy. 2020-05-11
32382932 For the treatment of emergency patients aside from routine epidemic prevention measures, some special measures for oral treatment need to be added. […] From January 23, 2020, to March 2, 2020, a total of 3035 patients received oral therapy during the COVID-19 epidemic in our hospital. […] To our knowledge, no oral health worker or patient has been infected with COVID-19 due to oral treatment, and no patients have complained about the suspension of treatment by complaints hotline. 2020-05-30
32383125 We describe the design of a clinical trial of hydroxychloroquine for post-exposure prophylaxis (PEP) and pre-emptive therapy (PET) for COVID-19. 2020-05-11
32383183 The convalescent plasma containing a high level of SARS-CoV-2 immunoglobulin G (IgG) antibody has been used in clinical therapy and achieved good effects in China. 2020-05-23
32383234 Associated symptoms, latency time, treatment, and prognosis were also carefully summarized. 2020-05-22
32383284 The patient was subsequently discharged on medical therapy but returned 3 days later due to worsening chest pain. 2020-05-08
32383430 Currently, there is no available treatment proven to be effective against COVID-19, but multiple medications, including hydroxychloroquine (HCQ), are used off label. […] We report the case of a 60-year-old woman without any cardiac history who developed right bundle brunch block and critically prolonged corrected electrocardiographic QT interval (QTc 631 ms) after treatment for 3 days with HCQ, which resolved on discontinuation of the medication. 2020-05-08
32383530 However, many clinicians feel ill equipped to deliver therapy via telehealth, while adhering to evidence-based interventions. […] Seventy clinical colleagues of the authors were emailed and invited to share their concerns online about how to deliver cognitive-behavioral therapy for eating disorders (CBT-ED) via telehealth, and how to adapt clinical practice to deal with the problems that they and others had encountered. 2020-05-08
32383624 The hypothesis has been proposed that patients COVID-19 positive, under anti-hypertensive treatment with angiotensin enzyme inhibitors or angiotensin receptor-blockers, might have a worse or a better clinical prognosis. 2020-05-08
32384004 The Novel Coronavirus SARS-CoV-2 (COVID-19) pandemic is changing how we deliver expert palliative care. […] Isolation of patients, limitation of visitors and interdisciplinary support, and changes in nursing and provider assessment have all had their impact on how we deliver palliative care. 2020-05-08
32384045 Using these markers for early identification of patients with severe disease may help healthcare providers prioritize the need to obtain therapy. 2020-05-08
32384183 Rapid identification of the haemophilia status, undelayed and regular liaison with the haemophilia team, proper therapy with factor concentrates or alternative treatments appear instrumental to prevent haemophilia-related complications in this setting. 2020-05-08
32384227 Although data are scarce at this stage, there is also an unexplained increased prevalence of obesity in patients infected with SARS-CoV-2 admitted to the intensive care units (ICU) (2). 2020-05-08
32384516 While several companies have already begun vaccine trials and healthcare facilities have been using a wide-range of medications to treat the virus and symptoms, there is not yet an approved medication regimen for COVID-19 infections. 2020-05-13
32384798 Systemic ozone therapy (OT) could be potentially useful in the clinical management of several complications secondary to SARS-CoV-2. 2020-05-11
32384917 Veno-venous extracorporeal membrane oxygenation (V-V ECMO) may serve as life-saving rescue therapy for refractory respiratory failure in the setting of acute respiratory compromise such as that induced by SARS-CoV-2. 2020-05-13
32385132 Therefore, patients with nervous system involvement as the presenting symptoms in the early stage of infection may easily be misdiagnosed and their treatment delayed. 2020-05-14
32385187 Many of these changes unfolded over days, including removing residents from outpatient services, minimizing the number of residents on inpatient services, deploying residents to medicine services and medical intensive care units, converting continuity clinic patient visits to virtual options, transforming didactics to online platforms only, and maintaining connectedness in an era of social distancing. 2020-05-29
32385225 With regard to the management of pregnant COVID-19 patients, in addition to the treatment of the infection itself, which is not that different from generally accepted principles, it is interesting to consider which obstetric procedures should be used to minimize the adverse effects on mother and child. 2020-05-12
32385458 To facilitate any move towards the resumption of widespread dental treatment, possibly without mass vaccination or the widespread use of antibody testing, the aerosol issue will need to be addressed and solved. 2020-05-13
32385628 Although the generalized advice to quit smoking as a measure to reduce health risk remains valid, the findings, together with the well-established immunomodulatory effects of nicotine, suggest that pharmaceutical nicotine should be considered as a potential treatment option in COVID-19. 2020-05-14
32385672 In this comprehensive review, we discuss the impact of COVID-19 on health and the immune system of those affected, reviewing the latest treatment approaches and ongoing clinical trials. 2020-05-12
32385712 SPMs also promote anti-viral B cell antibodies and lymphocyte activity, highlighting their potential use in the treatment of COVID-19. 2020-05-14
32385829 There is no proven medication for its treatment, so, all of the medications used for treatment are considered to be off-label. 2020-05-14
32385859 Psoriasis treatment relies on immunosuppression, and although most experts agree that the benefit-to risk-ratio is in favor of maintaining selective biologic therapies, and small molecules such as apremilast, they recommend dismission if severe COVID-19 symptoms occur. 2020-05-09
32385891 In this quick review we have analyzed the mechanisms of action and related infective risk of drugs used for the treatment of immune-mediated and oncologic skin conditions during the daily clinical practice. […] In the case of a COVID19 patient with complication (such as pneumonia, respiratory failure), treatment suspension should always be considered after taking into account the general condition of the patient, the risk-benefit ratio and the pathophysiology of COVID19 infection. […] The COVID19 emergency pandemic does not imply an under-treatment of existing skin conditions, which together with the SARS-Cov2 infection may jeopardize the patient’s life. 2020-05-09
32385982 Many phenomena and problems in the work of epidemic prevention, control and treatment are worthy of our deep reflection. 2020-05-12
32385985 The outbreak of coronavirus disease 2019 (COVID-19) is serious and there is no effective treatment to date. […] In order to reduce the mortality of severe and critical COVID-19, experts from the first-line in related fields in China were organized to analyze, discuss and summarize the diagnosis and treatment of severe and critical COVID-19 patients in Wuhan and other severe epidemic areas, and formulate the expert consensus. 2020-05-12
32385990 To discuss the research progress in the field of coronavirus (CoVs) treatment based on the visualization analysis of knowledge graph. […] The related literatures in the field of CoVs treatment were retrieved from the establishment of Web of Science core collection database to February 15th, 2020, and the literature analysis tool of Web of Science database was used to count the annual trend of published literatures. […] In terms of literature volume, the literatures on CoVs therapy rose after 2003 and 2012, and the number of published literatures had remained high since 2014. […] In terms of countries, the main countries that carried out the research on the treatment of CoVs were the United States (n = 613), China (n = 582), Germany (n = 122), Canada (n = 99), etc., and the cooperation among countries was close. […] In terms of institutions, the number of papers issued by Chinese Academy of Sciences in the field of CoVs treatment ranked first (n = 82), followed by University of Hong Kong of China (n = 74) and Chinese University of Hong Kong of China (n = 58), followed by National Institute of Allergy and Infectious Diseases (n = 37), and the cooperation among various institutions was close. […] The treatment hot spots focused on preventing virus adsorption, inhibiting the virus gene nucleic acid replication, transcription and translation. […] Through the visualization analysis of knowledge graph, the development trend and hot spots of CoVs therapy research could be well observed. […] In this study, the degree of attention in the field of CoVs treatment showed periodic changes, related to the outbreak of new CoVs, and the country, institutions and the author were closely related. […] The treatment hot spots focused on preventing virus adsorption, inhibiting the virus gene nucleic acid replication, transcription and translation in order to develop new targets of drug. 2020-05-12
32386011 There is no specific treatment so far. 2020-05-13
32386013 All patients had absorbed lesions on follow-up CT images after treatment. 2020-05-13
32386015 To determine imaging features of coronavirus disease 2019 (COVID-19) in different stages, and to provide foundations for early diagnosis and treatment. 2020-05-13
32386018 Early screening, early diagnosis, early isolation, and early treatment remain the most effective prevention and control measures. […] Computed tomography (CT) plays a vital role in the screening, diagnosis, treatment, and follow-up of COVID-19, especially in the early screening, with a higher sensitivity than that of real-time fluorescence RT-PCR. 2020-05-13
32386027 Significant improvement regarding the pathogenesis, epidemiology, and diagnosis and therapy for the COVID-19 has been achieved to stop the spread of the epidemics. 2020-05-13
32386125 The C19-GRA launched an international, secure, de-identified physician registry of patients with rheumatic diseases infected with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) to provide insights into the management and treatment of COVID-19 in this population. 2020-05-09
32386431 We have read with great interest the letter of the European Task Force on Atopic Dermatitis (ETFAD) on SARS-CoV-2-infection and atopic dermatitis published in JEADV (March 2020)1 in which the authors state: “Targeted treatment selectively interfering with type-2 inflammation such as dupilumab is not considered to increase the risk for viral infections and might thus be preferred …in a situation such as COVID-19 pandemic”.1. 2020-05-09
32386441 The Public Health Agency of Sweden has analysed how many pregnant and postpartum women with SARS-CoV-2 infection have been treated in intensive care units (ICU) in Sweden between the March 19 and April 20, 2020, compared with non-pregnant women of similar age. 2020-05-09
32386448 The antimalarials, Chloroquine and Hydroxychloroquine (HCQ), and the antivirals Lopinavir/Ritonavir have been recently recorded as having anti-severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) effects.1 In particular, regarding Italy, one of the countries most affected by the pandemic, the Italian Society of Infectious and Tropical disease (Lombardy section) has recommended the use of HCQ for treatment of coronavirus disease 2019 (COVID-19). 2020-05-09
32386460 It is a mildly symptomatic condition with an excellent prognosis, usually requiring no therapy. 2020-05-23
32386514 No intervention has yet been proven effective for the treatment of COVID-19. […] We will include randomized clinical trials comparing any intervention for the treatment of COVID-19 (e.g., pharmacological interventions, fluid therapy, invasive or noninvasive ventilation, or similar interventions) with any comparator (e.g., an “active” comparator, standard care, placebo, no intervention, or “active placebo”) for participants in all age groups with a diagnosis of COVID-19. […] Secondary outcomes will be admission to intensive care, mechanical ventilation, renal replacement therapy, quality of life, and non-serious adverse events. […] This review will continuously inform best practice in treatment and clinical research of this highly prevalent disease. 2020-05-13
32386567 Hence, surgical candidates face prolonged delays of beneficial treatment. 2020-05-29
32386712 We as a surgical community should herald their examples and re-focus our efforts to pioneer investigations into the coronavirus, helping elucidate the biology, understand its social effects, and provide effective treatment regimens for the disease. 2020-05-14
32386848 The direct and indirect effects of Coronavirus Disease-19 (COVID-19) pandemic, on Italian patients with lysosomal storage disorders receiving therapy, were analyzed by a phone questionnaire. […] Forty-nine% of patients receiving enzyme replacement therapy in hospitals experienced disruptions, versus 6% of those home-treated. 2020-05-14
32386875 Cancer therapy is complex, and outcomes are centered on timing. 2020-05-14
32386911 Highly immunosuppressive chemotherapy regimens and possible exposure to COVID-19 during treatment may put patients at additional risk. […] An expert panel convened to develop initial consensus guidelines regarding anti-neoplastic therapy during the COVID-19 pandemic with respect to gynecologic cancer care and clinical trials. 2020-05-14
32387014 Chlorpromazine (CPZ) is a phenothiazine derivative widely used in clinical routine in the treatment of acute and chronic psychoses. […] This first antipsychotic medication has been discovered in 1952 by Jean Delay and Pierre Deniker at Sainte-Anne hospital. […] The main objective is to demonstrate a shorter time to response (TTR) to treatment in the CPZ+standard-of-care (CPZ+SOC) group, compared to the SOC group. […] Response to treatment is defined by a reduction of at least one level of severity on the WHO-Ordinal Scale for Clinical Improvement (WHO-OSCI). […] CRP and lymphopenia); (D) a greater decrease in parenchymal involvement (chest CT) on the seventh day post-randomization; (E) to define the optimal dosage of CPZ and its tolerance; (F) to evaluate the biological parameters of response to treatment, in particular the involvement of inflammatory cytokines. […] This CPZ repositioning strategy also avoids numerous developmental and experimental steps and can save precious time to rapidly establish an anti-COVID-19 therapy with well-known, limited and easy to manage side effects. […] The broad spectrum of CPZ treatment - including antipsychotic, anxiolytic, antiemetic, antiviral, immunomodulatory effects along with inhibition of clathrin-mediated endocytosis and modulation of blood-brain barrier - is in line with the historical French commercial name for CPZ, i.e.  2020-05-14
32387040 Sofosbuvir active metabolite, however, shows an extremely high intracellular stability So, it is hypothesized that SARS-CoV-2 infection could also be susceptible to sofosbuvir and we were convinced to design and run a clinical trial to evaluate the effect of sofosbuvir 400 mg (in combination with velpatasvir 100 mg, as add-on treatment, in addition to standard of care) on the COVID-19. 2020-05-17
32387041 This case highlights a problematic ethical double standard in multinational clinical research: trials that would be considered unethical in high income countries (e.g., placebo-controlled where there is an existing treatment) are nonetheless justified in low-and-middle-income countries because the existing standards of care are less (i.e., no access to a treatment). 2020-05-14
32387058 This is particularly so for peritoneal neoplastic diseases, for which curative treatment mobilizes substantial personnel, operating room and intensive care resources. […] It is desirable to prioritize disease conditions for which cytoreduction surgery with or without associated hyperthermic intraoperative peritoneal chemotherapy (HIPEC) is the gold-standard treatment, and for which systemic chemotherapy cannot be a temporary or long-term alternative: pseudomyxoma peritonei, resectable malignant peritoneal mesotheliomas, peritoneal metastases of colorectal origin if they are resectable and unresponsive to systemic chemotherapy after up to 12 courses, first-line ovarian carcinomatosis if resectable or in interval surgery after at most six courses of systemic chemotherapy. 2020-05-22
32387061 However, the very nature of acute lymphoblastic leukemias and their treatment in children and adolescents led the Leukemia Committee of the French Society for the fight against cancers and leukemias in children and adolescents (SFCE) to propose more specific recommendations, even if data for this population are still scarce. 2020-05-24
32387139 The current coronavirus disease 2019 (COVID-19) pandemic has put significant strain on all aspects of health care delivery, including palliative care services. 2020-05-26
32387230 Amid the growing burden of the pandemic, there are parallel emergencies that need to be simultaneously tackled: the proliferation of fake medicines, fake news and medication misinformation surrounding COVID-19. […] Primarily, they can be a relevant source of accurate and reliable information to the public or other fellow health professionals thereby reducing the spread of COVID-19 medication misinformation. 2020-05-29
32387246 Where the diagnosis remains uncertain, an endomyocardial biopsy may help identify active cardiac infection through viral genome amplification and possibly refine the treatment risks of systemic immunosuppression. 2020-05-14
32387247 Many of the drugs being used in the treatment of the ongoing pandemic coronavirus disease 2019 (COVID-19) are associated with QT prolongation. 2020-05-14
32387301 A possible combined treatment algorithm for COVID-19 is here proposed. 2020-05-30
32387320 No therapy has yet proven effective in COVID-19. […] Tocilizumab (TCZ) in patients with severe COVID-19 could be an effective treatment. […] Patients with TCZ (n=20) had a higher Charlson comorbidity index (5.3 [±2.4] vs 3.4 [±2.6], P=0.014), presented with more severe forms (higher level of oxygen therapy at 13L/min vs 6L/min, P<0.001), and had poorer biological findings (severe lymphopenia: 676/mm3 vs 914/mm3, P=0.037 and higher CRP level: 158mg/L vs 105mg/L, P=0.017) than patients without TCZ (n=25). 2020-05-17
32387332 In this review, we describe some currently applied diagnostic approaches, as well as therapeutics and vaccines, to prevent, treat and control further outbreaks of SARS-CoV-2 infection. 2020-05-16
32387409 In France, the combination hydroxychloroquine (HCQ) and azithromycin (AZ) is used in the treatment of COVID-19. 2020-05-16
32387456 The parameters used for each COVID-19 positive patient were gender, hospitalization, admission to intensive care unit (ICU), death, tumor diagnosis, prostate cancer diagnosis, and androgen-deprivation therapy (ADT). 2020-05-14
32387574 Bereavement care is considered an integral component of quality end-of-life care endorsed by the palliative care movement. […] In this article, drawing on the palliative care and bereavement literature, we offer suggestions about how to incorporate palliative care tools and psychological strategies into bereavement care for families during this pandemic. 2020-05-30
32387575 These medicines, essential to palliative care, are regulated under the international drug control conventions overseen by United Nations (UN) specialized agencies and treaty bodies and under national drug control laws. […] This paper describes the issues related to the lack of availability and limited access to ICEMs during the COVID-19 pandemic in both intensive and palliative care patients in countries of all income levels and makes recommendations for improving access. 2020-05-14
32387694 While approved specific antiviral drugs against SARS-CoV-2 are still lacking, a large number of existing drugs are being explored as a possible treatment for COVID-19 infected patients. […] In an attempt to explore the evidence that supports their use in COVID-19 patients, we comprehensively reviewed the previous studies which used CQ or HCQ as an antiviral treatment. […] Given the current uncertainty, it is worth being mindful of the potential risks and strictly rationalise the use of these drugs in COVID-19 patients until further high quality randomized clinical trials are available to clarify their role in the treatment or prevention of COVID-19. 2020-05-22
32387778 In the current work, SARS-CoV-2 RNA was concentrated from wastewater in a catchment in Australia and viral RNA copies were enumerated using reverse transcriptase quantitative polymerase chain reaction (RT-qPCR) resulting in two positive detections within a six day period from the same wastewater treatment plant (WWTP). 2020-05-19
32388330 Early insulin therapy seems very promising in alleviating lung injury. 2020-05-27
32388331 On the contrary, direct β-cell damage, cytokine-induced insulin resistance, hypokalemia and drugs used in the treatment of COVID-19 (like corticosteroids, lopinavir/ritonavir) can contribute to worsening of glucose control in people with diabetes mellitus. 2020-05-27
32388333 IoT implementation impacts on reducing healthcare cost and improve treatment outcome of the infected patient. […] IoT is helpful for an infected patient of COVID-19 to identify symptoms and provides better treatment rapidly. 2020-05-27
32388451 Development of PML or other serious opportunistic infections during treatment with natalizumab forces to consider whether de-risking strategies are needed in this particular context and how to manage a high-efficacy treatment. […] This case supports the opportunity to avoid discontinuing or delaying the retreatment over 8 weeks in patients recovered from a recent COVID-19. 2020-05-27
32388458 They were receiving treatment with either amantadine (n=15) or memantine (n=7) in stable registered doses. 2020-05-26
32388486 The evidence shows that violet/blue (400-470 nm) light is antimicrobial against numerous bacteria, and that it accounts for Niels Ryberg Finsen’s Nobel-winning treatment of tuberculosis. 2020-05-27
32388805 Due to the current lack of effective pharmacological concepts, this situation has caused interest in (re)considering historical reports on the treatment of patients with low-dose radiation therapy for pneumonia. […] Although these historical reports are of low-level evidence per se, hampering recommendations for decision-making in the clinical setting, they indicate effectiveness in the dose range between 0.3 and 1 Gy, similar to more recent dose concepts in the treatment of acute and chronic inflammatory/degenerative benign diseases with, e.g., a single dose per fraction of 0.5 Gy. […] This concise review aims to critically review the evidence for low-dose radiation treatment of COVID-19 pneumopathy and discuss whether it is worth investigating in the present clinical situation. 2020-05-14
32388880 The neurological symptoms improved significantly during treatment with immunoglobulins. 2020-05-26
32388937 Objective: To evaluate the efficacy and safety of lopinavir/ritonavir (LPV/r) and arbidol in the treatment of COVID-19 in the real world. Methods: The clinical data of 178 patients diagnosed with COVID-19 admitted to Guangzhou Eighth People’s Hospital were retrospectively analyzed from January 21 to February 9, 2020. […] According to the patient’s antiviral treatment regimen, 178 patients were divided into 4 groups including LPV/r group (59 patients), arbidol group (36 patients), combination therapy with LPV/r plus arbidol group (25 patients) and the conventional treatment group without any antiviral drugs (58 patients). […] The main observation end points of the study was the negative conversion time of nucleic acid of the novel coronavirus (2019-nCoV) in pharyngeal swab. Results: The baseline of 4 groups before treatment was consistent and comparable. […] The negative conversion time of nucleic acid of the 2019-nCoV in pharyngeal swab was (10.20 ± 3.49), (10.11 ± 4.68), (10.86 ± 4.74), (8.44 ± 3.51) days separately in the LPV/r group, the arbidol group, the combination therapy group, and the conventional treatment group without significant difference (F = 2.556, P = 0.058). […] However, a statistically significant difference was found in the proportion of deterioration changing from mild/moderate to severe/critical type at day 7 (χ(2) = 9.311, P = 0.017) as follows: the combination therapy group (24.0%, 6/25), the arbidol group ( 16.7%, 6/36), LPV/r group (5.4%, 3/56) and conventional treatment group (5.2%, 3/58). […] Moreover, the frequency of adverse reactions in the three groups receiving antiviral drugs was significantly higher than that in the conventional treatment group (χ(2) = 14.875, P = 0.002). Conclusions: No evidences could prove that LPV/r and arbidol could shorten the negative conversion time of novel coronavirus nucleic acid in pharyngeal swab nor improve the symptoms of patients. […] Noteworthy, the adverse reactions of the antiviral drugs should be paid careful attention during the treatment. 目的: 评价真实世界中洛匹那韦/利托那韦(LPV/r)及阿比多尔治疗新型冠状病毒肺炎(COVID-19)的疗效和安全性。 2020-05-10
32388947 Among the 7 patients, 1 case died of (B) aggravation, and the other patients’ condition was effectively controlled after active treatment. 2020-05-12
32389025 Because of its higher potency and better safety profile, hydroxychloroquine may be the more reasonable treatment option if treatment is initiated. 2020-05-21
32389318 In addition, staff illness and restructuring of services to deal with the crisis will inevitably place treatment capacities under significant strain. 2020-05-13
32389492 For the first time, faced with a crisis with an exceptional magnitude due to the COVID-19 pandemic responsible for saturation of emergency services and intensive care units, the urolithiasis committee of the French Urology Association designed the recommendations for care and treatment of stone-forming patients and their treatment during crisis. 2020-05-14
32389518 Patients on renal replacement therapy (RRT) have not been unaware of this situation and due to their characteristics they are especially vulnerable. […] A very high percentage (85%) required hospital admission, 8% in intensive care units. 2020-05-14
32389538 Surgical tracheostomies have a role in the weaning process of COVID-19 patients treated in intensive care units. 2020-05-15
32389618 She was given atomization inhalation therapy with recombinant human interferon alfa-1b for 10 days. 2020-05-17
32389631 Pharmacists have long been involved in public health and emergency preparedness and response (EP&R), including through preventive measures such as screening, vaccinations, testing, medical and pharmaceutical countermeasures, as well as ensuring medication safety and access during natural disasters and pandemics. 2020-05-15
32389695 The pandemic is exposing, with terrible clarity, the disparities in human society-racism,6 poverty,7,8 domestic violence,9,10 and child maltreatment and neglect11-and tragically will likely amplify the negative impacts that each has on child development and mental health. 2020-05-30
32389697 In this paper, we report the results of plasmapheresis treatment in a series of severely ill patients with COVID-19-related autoimmune meningoencephalitis in the Intensive Care Unit (ICU). 2020-05-18
32389755 In addition to making practice changes to cope with the adverse realities, oncologists should also work together to raise pragmatic suggestions to policy makers and be strong advocates to protect our patients from the detrimental effect of delay or compromised treatment. 2020-05-31
32389859 We discuss the implications of COVID-19 infections for FH patients, the importance of continuing lipid-lowering therapy where possible, issues relating to safety monitoring and service delivery. 2020-05-31
32389940 With the explosive growth of confirmed cases, emergency medical supplies are facing global shortage, which restricts the treatment of seriously ill patients and protection of medical staff. 2020-05-11
32390367 All patients received antibiotic therapy, and most (97/98 patients; 99.0%) received antiviral therapy (lopinavir/ritonavir). […] Hydroxychloroquine was used in 79 patients (80.6%), and glucocorticoid therapy was used in 18 patients (18.4%). 2020-05-12
32390971 We will discuss the potential of AAV-based gene therapy technology for in vivo therapeutic antibody delivery to combat SARS-CoV-2 outbreak and the future emergence of severe CoVs. 2020-05-15
32391169 During infection and its complication such as sepsis, hypotension could be exacerbated by antihypertensive drugs because homeostasis mechanisms such as sodium balance, renin angiotensin aldosterone system and/or sympathetic nervous system can be mitigated by antihypertensive drug therapy. 2020-05-15
32391234 We describe the clinical presentation of this patient, the diagnostic process, the laboratory and imaging investigations, as well as the course of treatment. 2020-05-15
32391242 Precision medicine (PM) represents a new paradigm in disease diagnosis, prevention, and treatment. […] Better understanding of pathogenic pathways together with an accurate phenotype classification of patients presented with SARS-CoV-2 infection and symptoms might contribute to a more accurate definition of biomarkers and other diagnostic tools, which may lead to more precise mitigation strategies, personalized pharmacologic options, as well as new biological therapy developments. 2020-05-15
32391282 In this historical moment, medical oncologists are required to consider the possibility to delay active treatment administration based on a case-by-case risk/benefit evaluation. […] Potential risks associated with COVID-19 infection should be considered, considering tumor histology and natural course, disease setting, clinical conditions, and disease burden, together with the expected benefit, toxicities (e.g., myelosuppression or interstitial lung disease), and response obtained from the planned or ongoing treatment. […] Proactive management and containment measures, applied in a structured and daily way, has significantly aided the identification of advance patients with suspected symptoms related to COVID-19, limiting their admission to our cancer center; we have thus been more able to protect other patients from possible contamination and at the same time guarantee to the suspected patients the immediate treatment and evaluation in referral hospitals for COVID-19. 2020-05-15
32391308 Furthermore, given that a relevant proportion of infected people need hospitalization in Intensive Care Units, this may be a crucial issue for National Healthcare System’s capacity. 2020-05-15
32391369 The aim was to investigate the effectiveness of glucocorticoid therapy in patients with COVID-19. 2020-05-15
32391519 Treatment and neonatal outcomes are also reported. 2020-05-11
32391657 Early identification, early isolation, early diagnosis and early treatment are important for clinical management. […] The treatment of mild or moderate type of child COVID-19 is mainly symptomatic. […] For severe and critical ill cases, the oxygen therapy, antiviral drugs, antibacterial drugs, glucocorticoids, mechanical ventilation or even extracorporeal membrane oxygenation (ECMO) may be adopted, and the treatment plan should be adjusted timely through multi-disciplinary cooperation. 2020-05-12
32391658 Based on the present expert consensus carried out by National Health Commission and National Administration of Traditional Chinese Medicine, our team summarized and established an effective treatment strategy centered on “Four-Anti and Two-Balance” for clinical practice. […] Meanwhile, integrated multidisciplinary personalized treatment was recommended to improve therapeutic effect. […] Early antiviral treatment could alleviate disease severity and prevent illness progression, and we found lopinavir/ritonavir combined with abidol showed antiviral effects in COVID-19. […] The artificial liver blood purification system could rapidly remove inflammatory mediators and block cytokine storm.Moreover, it also favored the balance of fluid, electrolyte and acid-base and thus improved treatment efficacy in critical illness. […] Conservative oxygen therapy was preferred and noninvasive ventilation was not recommended. […] We also integrated Chinese medicine in treatment to promote disease rehabilitation through classification methods of traditional Chinese medicine. […] However, since COVID-19 was a newly emerging disease, more work was warranted to improve strategies of prevention, diagnosis and treatment for COVID-19. 2020-05-12
32391659 Severe and critically ill patients with coronavirus disease 2019 (COVID-19) were usually with underlying diseases, which led to the problems of complicated drug use, potential drug-drug interactions and medication errors in special patients. […] Based on Diagnosis and treatment of novel coronavirus pneumonia (trial version 6), and Management of COVID-19: the Zhejiang experience, we summarized the experience in the use of antiviral drugs, corticosteroids, vascular active drugs, antibacterial, probiotics, nutrition support schemes in severe and critically ill COVID-19 patients. […] It is also suggested to focus on medication management for evaluation of drug efficacy and duration of treatment, prevention and treatment of adverse drug reactions, identification of potential drug-drug interactions, individualized medication monitoring based on biosafety protection, and medication administration for special patients. 2020-05-12
32391661 By using Euler integral algorithm to solve the modified SEIR dynamics model, the epidemic situation in Hubei province was analyzed, and the impact of prevention and control measures such as quarantine and centralized treatment on the epidemic development was discussed. […] Theoretical analysis showed that prevention and control quarantine and medical follow-up quarantine played an important inhibitory effect on the outbreak of the epidemic.The centralized treatment played a key role in the rapid decline in the number of infected people. 2020-05-12
32391663 The chest CT images of patients with COVID-19 have certain characteristics with dynamic changes, which are of value for monitoring disease progress and clinical treatment. 2020-05-12
32391664 A total of 67 patients diagnosed as COVID-19 by nucleic acid testing were collected and divided into 4 groups according to the clinical stages based on Diagnosis and treatment of novel coronavirus pneumonia (trial version 6). 2020-05-12
32391665 During the isolation treatment of suspected COVID-19 patients, early psychological intervention should be carried out for the female patients with known contact history of epidemic area and personnel in epidemic area, and drug treatment should be given in advance if necessary. 2020-05-12
32391666 To analyze the roles of multidisciplinary team (MDT) in the diagnosis and treatment of suspected cases of coronavirus disease 2019 (COVID-19). […] With the guidance of MDT, one COVID-19 patient was transferred to designated provincial hospital after effective treatment; one patient complicated with acute cholecystitis underwent gallbladder puncture and drainage; and COVID-19 was excluded in a highly suspected patient after alveolar lavage fluid examination. […] The efficiency of diagnosis and treatment for suspected COVID-19 patients can be improved with MDT, particularly for complicated cases. 2020-05-12
32391667 To evaluate the efficacy and safety of hydroxychloroquine (HCQ) in the treatment of patients with moderate coronavirus disease 2019 (COVID-19). […] We prospectively enrolled 30 treatment-naïve patients with confirmed COVID-19 after informed consent at Shanghai Public Health Clinical Center. […] Patients in HCQ group were given HCQ 400 mg per day for 5 days plus conventional treatments, while those in the control group were given conventional treatment only. […] One patient in HCQ group developed to severe during the treatment. […] Larger sample size study are needed to investigate the effects of HCQ in the treatment of COVID-19. 2020-05-12
32391668 To investigate the effect of corticosteroids therapy on the inflammatory response in a critically ill coronavirus disease 2019 (COVID-19) patient. […] Thereafter, the dose was adjusted in a timely manner and the therapy lasted for 13 days. 2020-05-12
32391669 To observe the clinical effect of plasma exchange and tocilizumab in treatment of patients with severe coronavirus disease 2019 (COVID-19). […] The C-reactive protein (CRP) and IL-6 levels were significantly decreased and the lymphocyte and prothrombin time were improved in 3 patients after treatment with plasma exchange; while inflammation level was not significantly decreased, and lymphocyte and prothrombin time did not improve in 3 patients treated with tocilizumab. 2020-05-12
32391670 We applied HFNC for oxygen therapy in severe and critical ill COVID-19 patients and summarized the following experiences. […] Thirdly, to avoid hypoxia or hypoxemia, the treatment goal of HFNC should be maintained the oxygen saturation (SpO2) above 95% for patients without chronic pulmonary disease. […] Finally, patients should wear a surgical mask during HFNC treatment to reduce the risk of virus transmission through droplets or aerosols. 2020-05-12
32391671 The report shows that COVID-19 in pregnancy women could be cured with active treatment, and the maternal and fetal outcomes can be satisfactory. 2020-05-12
32391672 The inflammation indicators and fever of this patient were effectively controlled and the lung lesions remained stable after active anti-viral treatment, then the radical colorectomy was performed after the viral negative conversion for twice. 2020-05-12
32391675 To analysis the medication characteristics of the prescriptions issued via open channel by the National and Provincial Health Committee and the State Administration of Traditional Chinese Medicine in treating coronavirus disease 2019 (COVID-19). […] We collected the data of traditional Chinese medicine related to treatment plans published by the National and Provincial Health Committee and the State Administration of Traditional Chinese Medicine from the start of COVID-19 outbreak to February 19, 2020. […] The study collected 4 national and 34 regional prevention and treatment plans, 578 items, 84 traditional Chinese formulations, 60 Chinese patent medicines, and 230 Chinese herbs. […] The main medication characteristics are clearing heat, entilating lung, removing toxicity and removing turbidity. 2020-05-12
32391741 Overall, the most common CT findings were ground glass opacity (114/119, 96%) and consolidation (47/119,40%). 29/119 (24%) patients required major interventions (vasopressor medication or intubation) and 27/119 (23%) died. 2020-05-11
32391877 Clinical, laboratory, and treatment data were collected and compared between patients who died and survivors. 2020-05-29
32391999 Since the outbreak of COVID-19, chloroquine has been mentioned as a possible treatment. […] Recently, the Dutch National Institute for Public Health and the Environment published treatment options for antiviral treatment for COVID-19 where chloroquine was suggested as first choice for off-label treatment, beside remdesivir en lopinavir/ritonavir. 2020-05-20
32392007 The current guidelines for diagnosis and treatment of primary respiratory infections are still useful during the COVID-19 epidemic.Telephone triage of patients with respiratory complaints aims to identify patients with complications or an increased risk of complications.There are no indications to test for SARS-CoV-2 virus in general practice.During this COVID-19 epidemic, protective clothing is recommended in all physical contacts with patients with respiratory complaints.There is no reason to be cautious about using NSAIDs in patients suspected of COVID-19. […] Amoxicillin is first choice treatment for respiratory infections during the COVID-19 epidemic; there is lack of evidence to support azithromycin as a first choice.Respiratory rate > 24 / min or saturation <92-94% indicate imminent respiratory decompensation and may be reasons for referral. 2020-05-20
32392282 Among patients hospitalized in metropolitan New York with COVID-19, treatment with hydroxychloroquine, azithromycin, or both, compared with neither treatment, was not significantly associated with differences in in-hospital mortality. 2020-05-20
32392288 While there is evidence that the burden of COVID-19 infection in hospitalized children is lesser than in their adult counterparts, to date, there are only limited reports describing COVID-19 in pediatric intensive care units (PICUs). 2020-05-11
32392333 A breakdown of treatment and prevention services for these conditions may even overshadow the projected morbidity and mortality from COVID-19. 2020-05-29
32392473 Diabetes-related factors of glycemic control, medication pharmacodynamics, and insulin access can impact the severity of a COVID-19 infection. 2020-05-18
32392559 The biology of each leukemia and its corresponding treatment with conventional intensive chemotherapy, with or without targeted therapies (venetoclax, FLT3 inhibitors, IDH1/2 inhibitors, Bruton’s tyrosine kinase inhibitors), introduce additional layers of complexity during COVID-19 high-risk periods. 2020-05-11
32392562 However, more studies are needed to clarify the efficacy of these therapeutics. […] In addition to antiviral therapy, potential ACE2- and AT1-R-inhibiting strategies, and other supportive care, we suggest other potential JAKinibs and novel anti-inflammatory combination therapies that affect the JAK-STAT pathway in patients with COVID-19. 2020-05-11
32392624 A group was formed, comprising three senior geriatricians, a former dean, a palliative care specialist, and a lawyer/ethicist. […] Recommendations included the approach to older persons both in the community and in long-term care institutions, a triage instrument, and palliative care. […] The guideline emphasized that no matter what, in the spirit of beneficence, anyone who fell ill must receive active palliative care throughout the course of a COVD-19 infection but especially at the end of life. 2020-05-23
32392741 Fibrinogen seems to increase early in COVID-19 patients and may be used as a risk stratification marker for the early detection of a subgroup of COVID-19 patient at increased risk to develop SARS, who might benefit from a different and thorough clinical surveillance and treatment. 2020-05-12
32392859 This is an important issue to be identified in order to provide more specific therapy earlier, including both antiviral and anti-inflammatory drugs associated with anti anticoagulant therapy. 2020-05-12
32393325 Preparing intensive care units (ICU) is an integral part of any pandemic response. 2020-05-13
32393381 Perceived causes of infection, infection prevention, control knowledge and behaviour, psychological changes, symptoms and treatment were measured. 2020-05-14
32393401 Given its rare side effects and relatively wide safety, prophylactic vitamin D supplementation and/or food fortification might reasonably serve as a very convenient adjuvant therapy for these two worldwide public health problems alike. 2020-05-12
32393438 The method is a powerful tool for studying the underlying mechanism of platelet aggregation and is expected to open a window on an entirely new class of clinical diagnostics, pharmacometrics, and therapeutics. […] Blood clots have also been linked to harmful inflammation and the spread of cancer, and there are now preliminary reports of remarkably high rates of clotting in COVID-19 patients in intensive care units. […] This could help them choose whether aspirin or another anti-platelet drug would be the best treatment. 2020-05-14
32393447 Temporary closure of outpatient health facilities in some secondary and tertiary care hospitals have deprived millions of NCD patients of their regular medication and diagnostic health needs. 2020-05-14
32393448 The WHO and the FDA have not found adequate evidence to recommend any specific medication for the treatment of Covid-19. 2020-05-14
32393594 Management of COPD with COVID-19 warrants standard-of-care treatment with antimicrobial agents and corticosteroids, though limiting the dose and duration of steroids use may be warranted due to the risk of increased viral shedding. 2020-05-12
32393597 HCQ is the only SLE treatment shown to increase survival and any change in the HCQ regimen is potentially dangerous. […] Providers need to make thoughtful, informed decisions in this time of medication shortage. 2020-05-12
32393664 We found that the average patient receiving treatment with hydroxychloroquine for rheumatic diseases, including children and non-pregnant/pregnant adults, are unlikely to achieve total serum or plasma concentrations shown to inhibit SARS-CoV-2 in-vitro. 2020-05-12
32393985 Evidence of the benefits of vitamin C (VC) for the treatment of sepsis is accumulating. 2020-05-12
32394153 Prevention and risk reduction strategies are paramount in the current absence of effective treatment or a vaccine. 2020-05-15
32394237 Rarely, pulmonary embolism may be encountered in patients with severe COVID-19 infection, especially in intensive care units. 2020-05-15
32394338 The current coronavirus disease (COVID-19) pandemic has caused significant mortality over a short time and has necessitated an increase in provision of both critical care and palliative care. 2020-05-15
32394344 All patients were on antiretroviral treatment, of them 22 on tenofovir-containing regimen and 4 on the protease inhibitor darunavir. 2020-05-15
32394416 On the other hand, patients, who need emergency healthcare, should also be provided with appropriate treatment. […] Healthcare professionals should choose a treatment method appropriately in the circumstances to protect themselves and their patients as much as possible. 2020-05-13
32394467 Neuraminidase inhibitors such as oseltamivir, peramivir, and zanamivir are invalid for 2019-nCoV and are not recommended for treatment but protease inhibitors such as lopinavir/ritonavir (LPV/r) inhibit the progression of MERS-CoV disease and can be useful for patients of COVID-19 and, in combination with Arbidol, has a direct antiviral effect on early replication of SARS-CoV. […] Favipiravir increases clinical recovery and reduces respiratory problems and has a stronger antiviral effect than LPV/r. currently, appropriate treatment for patients with COVID-19 is an ACE2 inhibitor and a clinical problem reducing agent such as favipiravir in addition to hydroxychloroquine and corticosteroids. 2020-05-12
32394481 On March 16, 2020, the French Society of Pharmacology and Therapeutics put online a national Question and Answer (Q&A) website, on the proper use of drugs during the COVID-19 pandemic. 2020-05-12
32394639 The importance of DPP4 for the medical community has been highlighted by the approval of DPP4 inhibitors, or gliptins, for the treatment of type 2 diabetes mellitus. 2020-05-27
32395064 Due to overall rising cancer incidence and specific concerns, a cohort of cancer patients forms a distinct subset of the population in whom a correct and timely treatment has a huge impact on the outcome. 2020-05-15
32395179 The value of extracorporeal membrane oxygenation (ECMO) for patients suffering from novel coronavirus disease 2019 (COVID-19) as a rescue therapy for respiratory failure remains controversial and associated with high mortality rates of 50 to 82% in early reports from Wuhan, China. […] We hypothesized that patient outcomes would be improved at our tertiary cardiothoracic surgery referral center with a protocolized team-approach for ECMO treatment of patients with severe COVID-19 disease. […] Her respiratory status continued to deteriorate despite maximized critical care, including prone positioning ventilation and nitric oxide inhalation therapy. […] Veno-venous ECMO was initiated on hospital day 7 in conjunction with a 10-day course of compassionate use antiviral treatment with remdesivir. […] This case report demonstrates a positive outcome in a young patient with COVID-19 treated by the judicious application of ECMO in conjunction with compassionate use antiviral treatment (remdesivir). 2020-05-15
32395417 More research is required, especially in the treatment and prevention of the disease, so that we may progress towards finding a cure as well as creating a vaccine for the COVID-19. 2020-05-15
32395418 In this review, we will update and summarize the most common and plausible drugs for the treatment of COVID-19 patients. 2020-05-15
32395419 In this special Theme issue, we would like to discuss the latest treatment modalities available around the world in tackling this dreadful disease. 2020-05-15
32395474 Previous experimental data revealed ACE2 level was increased following treatment with ACE inhibitors (ACEIs) and angiotensin receptor blockers (ARBs). 2020-05-15
32395542 Also, treatment principles may various for CRC patients with or without severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, as well as patients with or without an emergency presentation. 2020-05-15
32395550 At last, the prognosis was good after active treatment. […] After antiviral and anti-infective treatment, the symptoms recovered. 2020-05-15
32395606 The strategy in virtual screening of antiviral databases for possible therapeutic effect would be to identify promising drug molecules, as there is currently no vaccine or treatment approved against COVID-19. 2020-05-27
32395672 As the COVID-19 pandemic spreads around the globe, access to radiation therapy remains critical for cancer patients. […] The priority for all radiation oncology departments is to protect the staff and to maintain operations in providing access to those patients requiring radiation therapy services. […] Patients with tumors of the aerodigestive tract and pelvis amongst others often experience toxicity during treatment, and there is a baseline risk that adverse effects may require hospital-based management. […] Routine care during weekly visits is important to guide patients through treatment and to mitigate against the need for hospitalization. […] Recognizing the need to provide access to treatment and the anticipated toxicity of such treatment, we have developed and implemented guidelines for clinical care management with the hope of avoiding added risk to our patients. 2020-05-15
32395850 The Australian Treatment Outcomes Profile (ATOP) is a brief clinical tool measuring recent substance use, health and wellbeing among clients attending alcohol and other drug (AOD) treatment services. […] We recruited a sample of 107 AOD clients across public sector specialist AOD treatment services in New South Wales, Australia between 2016 and 2018. […] Among 107 participants, 59% were attending for alcohol treatment and 41% for opioid treatment. 2020-05-12
32396134 Patients established on denosumab and teriparatide should continue planned therapy. 2020-05-12
32396143 Therefore, it is best to be regularly assessed these markers during treatment of COVID-19 patients. 2020-05-12
32396163 Early identification of patients with novel corona virus disease 2019 (COVID-19) who may develop critical illness is of great importance and may aid in delivering proper treatment and optimizing use of resources. 2020-05-20
32396382 News and social media platforms have implicated dietary supplements in the treatment and prevention of coronavirus disease 2019 (COVID-19). […] Rather, reference to evidence-based guidelines should guide treatment decisions. 2020-05-12
32396397 Case histories describe the remote initiation of insulin pump therapy and automated insulin delivery in T1D pregnancy. Results: Initial feedback suggests that video consultations are well received and that the patient experiences for women requiring face-to-face visits are greatly improved. 2020-05-19
32396445 Data on demographics, comorbidities, COVID-19 symptoms and severity, consult reason, treatment, and personal protective equipment (PPE) use were collected and analyzed. […] Otolaryngologists play an indispensable role in the treatment of COVID-19 patients but, due to their work, are at high risk of exposure. 2020-05-15
32396446 Here we present considerations in regard to treatment with quinine-derived drugs and the influence of masks on communication. 2020-05-12
32396455 The COVID-19 outbreak poses continued struggles due to the unprecedented number of patients admitted to intensive care units and the overwhelming need for mechanical ventilation. 2020-05-12
32396601 To provide a comprehensive summary of the implications of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and coronavirus disease 2019 (COVID-19) on orthodontic treatment, contingency management, and provision of emergency orthodontic treatment, using currently available data and literature. […] During the spread of the COVID-19 pandemic, elective orthodontic treatment should be suspended and resumed only when permitted by federal, provincial, and local health regulatory authorities. […] Emergency orthodontic treatment can be provided by following a contingency plan founded on effective communication and triage. […] Treatment advice should be delivered remotely first when possible, and where necessary, in-person treatment can be performed in a well-prepared operatory following the necessary precautions and infection prevention and control (IPAC) protocol. 2020-05-12
32396683 Stroke care in India has evolved rapidly in the last decade with a focus on stroke awareness, prevention, rapid triage, treatment, and rehabilitation. […] There is a need for public health systems in both developed and developing countries to improve awareness, implement proper strategies of triage, acute treatment, well-defined rehabilitation plans, telemedicine services, and virtual check-ins. 2020-05-12
32396771 Remdesivir has been recently a strong candidate for the treatment of Covid-19. […] Therefore, future disposal of agents such as remdesivir might be crucial for ensuring an efficient treatment, decrease mortality and allow early discharge.Communicated by Ramaswamy H. 2020-05-30
32396773 Furthermore, prediction of tACE2 soluble expression in E. coli makes it a suitable candidate to be targeted for Covid-19 therapeutics. 2020-05-30
32396903 Presently, the incidence of VTE is estimated at around 25% of patients hospitalized in the intensive care unit for COVID-19 even under anticoagulant treatment at prophylactic doses. […] In this review, we discuss present knowledge of the topic, the unique challenges of diagnosis and treatment of VTE, as well as some of the potential mechanisms of increased risk for VTE during the illness. […] Understanding the true impact of VTE on patients with COVID-19 will potentially improve our ability to reach a timely diagnosis and initiate proper treatment, mitigating the risk for this susceptible population during a complicated disease. 2020-05-12
32396985 Children/young adults seem to have a less severe clinical manifestation of COVID-19 (2), but data on disease susceptibility in pediatric transplant recipients on chronic immunosuppressive therapy are limited (3, 4). […] This poses major uncertainties regarding pediatric transplant activity and management of anti-rejection therapy. 2020-05-12
32396996 There is a pressing need to improve our understanding of the immunology of this disease to contain the pandemic by developing vaccines and medicines for the prevention and treatment of patients. 2020-05-12
32397000 Accordingly, such measures have led to concerns over how to maintain access to haemophilia treatment products and to the specialized integrated care medical follow up within the haemophilia treatment centers (HTCs). 2020-05-12
32397174 Indeed, treatment of CRS involves the use of both antivirals to control the underlying infection and immunosuppressive agents to dampen the aberrant pro-inflammatory response of the host. […] Autoimmune patients receiving immunosuppressants could be prone to SARS-CoV-2 infections; however, suspension of the ongoing therapy is contraindicated to avoid disease flares and a consequent increase in the infection risk. 2020-05-14
32397399 Objective: This study aimed to assess the role of Tocilizumab therapy (TCZ) in terms of ICU admission and mortality rate of critically ill patients with severe COVID-19 pneumonia. Design: Patients with COVID-19 pneumonia were prospectively enrolled in SMAtteo COvid19 REgistry (SMACORE). […] This study found that treatment with TCZ did not significantly affect ICU admission (OR 0.11; 95% CI between 0.00 and 3.38; p = 0.22) or 7-day mortality rate (OR 0.78; 95% CI between 0.06 and 9.34; p = 0.84) when compared with SOC. […] Analysis of laboratory measures showed significant interactions between time and treatment regarding C-Reactive Protein (CRP), alanine aminotransferase (ALT), platelets and international normalized ratio (INR) levels. […] Variation in lymphocytes count was observed over time, irrespective of treatment. Conclusions: TCZ administration did not reduce ICU admission or mortality rate in a cohort of 21 patients. 2020-05-13
32397684 The current pandemic coronavirus, SARS-CoV-2, is a global health emergency because of its highly contagious nature, the great number of patients requiring intensive care therapy, and the high fatality rate. […] In the absence of specific antiviral drugs, passive prophylaxis, or a vaccine, the treatment aim in these patients is to prevent the potent virus-induced inflammatory stimuli from leading to the acute respiratory distress syndrome (ARDS), which has a severe prognosis. 2020-05-14
32397688 Moreover, we provide an extensive list of resources that will help the scientific community access numerous types of databases related to SARS-CoV-2 OMICs and approaches to therapeutics related to COVID-19 treatment. 2020-05-19
32397940 The lack of targeted therapeutics and limited treatment options have triggered the scientific community to develop new vaccines or small molecule therapeutics against various targets of SARS-CoV-2. 2020-05-30
32398164 Drug repurposing/repositioning, a strategy effectively employed in cancer treatment, can represent a valid alternative. […] Most drugs considered for repurposing/repositioning in the therapy of the COVID-19 outbreak are commercially available and their dosage and toxicity in humans is well known, due to years (or even decades) of clinical use. […] Several drugs being re-considered for COVID-19 therapy are or have been used in cancer therapy. […] We present here a comprehensive analysis of available information on potential candidate cancer drugs that can be repurposed for the treatment of COIVD-19. 2020-05-14
32398243 It is currently unknown whether PD-1 blockade therapy impacts severity of illness from COVID-19 in patients with cancer. 2020-05-13
32398268 The patient’s condition improved after adjustment of therapy at home. […] We emphasise the utility and the opportunity that LUS presents in some clinical scenarios, like this COVID-19 pandemic, and how it may serve as a monitoring and therapy guide. 2020-05-13
32398343 While novel drugs are being developed, azithromycin has been identified as a candidate treatment in the interim. […] In vivo and in vitro studies were included assessing the safety and effectiveness of azithromycin for treatment of COVID-19, and/or the activity of azithromycin against SARS-CoV-2. […] There is no evidence to support the use of azithromycin for the treatment of COVID-19 outside of the context of clinical trials, unless it is used to treat bacterial super-infection. 2020-05-13
32398383 We provide the rationale for launching medical activities and indicate optimal practices until the consolidation of SARS COV-2 prevention and treatment methods. 2020-05-14
32398569 Children rarely needed admission to intensive care units (3%), and to date, only a small number of deaths have been reported in children globally. 2020-05-18
32398607 Combination therapy is well established in hypertension. […] Many guidelines recommend dual antihypertensive therapy as the initial treatment step as this results in faster blood pressure control, albeit with limited evidence of improved outcomes. […] Control of CVD risk factors through multiclass combination therapy (the polypill) was proposed many years ago. 2020-05-13
32398876 Serological assays are of critical importance to help define previous exposure to SARS-CoV-2 in populations, identify highly reactive human donors for convalescent plasma therapy and investigate correlates of protection. 2020-05-13
32398901 The limited biomedical and epidemiological understanding of COVID-19 along with the lack of vaccines and therapeutics have led to the reception of draconian measures from the societal safety domain, limiting human interaction through social distancing. 2020-05-28
32398902 Self-treatment (without medication) was the most used method when having health problems (by 28.2% to 51% of participants), followed by visiting commune health centers (24%) and self-medication (20.3%). 2020-05-16
32399449 Anticoagulant treatment is associated with decreased mortality in severe COVID-19 pneumonia. 2020-05-16
32399452 COVID-19 can co-occur with other viral infections.Some of these co-infections have active treatments, while supportive treatment is the mainstay of treatment for others. 2020-05-16
32399455 There is no proven antiviral therapy for COVID-19 so far, but profound immunosuppression has recently been suggested as a treatment for COVID-19-associated CRS. […] We present a case of life-threatening CRS caused by COVID-19 infection with a favourable response to immunosuppressive therapy with tocilizumab (TCZ). […] The rapid clinical and biochemical improvement following TCZ administration suggests that treatment with immunotherapy can be life-saving in selected patients with COVID-19-induced CRS. […] Cytokine release syndrome may cause sudden and potentially life-threatening clinical deterioration in COVID-19 pneumonia, particularly in younger patients.Immunosuppressive therapy may provide important additional therapeutic benefit in these patients.Tocilizumab, a specific IL-6 inhibitor, led to dramatic clinical improvement in a young patient with severe COVID-19-associated cytokine release syndrome. 2020-05-16
32399457 These thrombotic events include stroke, venous thromboembolism, pulmonary embolism and cardiac complications.Clinicians should carefully consider the risk of thrombosis in patients positive for COVID-19, including prophylaxis and treatment beyond discharge. 2020-05-16
32399481 The preferred imaging modality is chest computed tomography (CT) which plays an important role in early diagnosis, quarantine, and treatment as well as in the evaluation of therapeutic efficacy. 2020-05-13
32399620 Median chest CT scores peaked at 4 days after the beginning of treatment and then declined. 2020-05-16
32399719 CNS symptoms could be a potential indicator of poor prognosis; therefore, the prevention and treatment of CNS symptoms are also crucial for the recovery of COVID-19 patients. 2020-05-29
32399806 Hematologic consequences of this new infection allowed medical community to start new treatment approaches concerning infection going from targeted anti-inflammatory drugs to anticoagulation or stem cell therapies. […] A better understanding of Covid-19 pathophysiology, in particular hematological disorders, will help to choose appropriate treatment strategies. 2020-05-16
32399942 The allocation of hospital beds and ventilators, personal protective equipment, investigational therapeutics, and other scarce resources has required difficult decisions. 2020-05-16
32399995 To date, no study attempted to quantify the impact of the Covid-19 outbreak on incidence and treatment of acute stroke. 2020-05-13
32400049 The rapid diffusion of the SARS-CoV-2 together with the need for isolation for infected patients might be responsible for a suboptimal treatment for SARS-CoV-2 ACS patients. 2020-05-13
32400074 The first patient always maintained excellent oxygen saturation throughout hospitalization with no need for additional oxygen therapy. 2020-05-13
32400084 Both patients were on triple immunosuppressive therapy and had no signs of allograft dysfunction. […] Immunosuppressive therapy was unchanged and no experimental treatment was initiated. 2020-05-13
32400380 This review aims to elucidate potential mechanisms, which make HCQ treatment interesting in the fight against SARS-CoV-2 infection, as well as the current evidence for clinical use of HCQ to treat COVID-19. 2020-05-18
32400911 Cognitive processing therapy (CPT) is a trauma-focused, evidence-based treatment for posttraumatic stress disorder that is effective when delivered in-person or via telehealth. […] Given current limitations on the provision of in-person mental health treatment during the COVID-19 pandemic, this article presents guidelines and treatment considerations when implementing CPT via telehealth. […] Based on lessons learned from prior studies and clinical delivery of CPT via telehealth, recommendations are made with regard to overall strategies for adapting CPT to a telehealth format, including how to conduct routine assessments and ensure treatment fidelity. 2020-05-13
32400924 The COVID-19 pandemic is one of the most serious global challenges to delivering affordable and equitable treatment to children with cancer we have witnessed in the last few decades. […] We provide some practical advice for adapting diagnostic and treatment protocols for children with cancer during the pandemic, the measures taken to contain it (e.g., extreme social distancing), and how to prepare for the anticipated recovery period. 2020-05-29
32400965 These drugs may be used tentatively for general population with COVID-19, but for solid organ transplant (SOT) recipients with long-term immunosuppressive therapy and drug-related metabolic diseases, antiviral drugs should be chosen with particular care. 2020-05-13
32401064 The current outbreak of pneumonia caused by 2019 novel coronavirus (COVID-19) illustrated difficulties in lack of effective drugs for treatment. […] Accurate and rapid diagnostic tools are essential for early recognition and treatment of infectious diseases, allowing timely implementation of infection control, improved clinical care and other public health measures to stop the spread of the disease. 2020-05-26
32401359 One patient with prior HIV-infection continued anti-HIV treatment when diagnosed with COVID-19. […] The other patient was newly diagnosed with HIV-infection when diagnosed with COVID-19 and had not begun anti-HIV treatment. […] Both patients were treated with anti-viral, antibiotics, oxygen treatment and supportive care and recovered from severe pneumonia. 2020-05-13
32401360 Patients with cancer may have compromised immunity due to their malignancy and/or treatment, and may be at elevated risk of severe COVID-19. […] During the COVID-19 pandemic: In patients with cancer with fever and/or respiratory symptoms, consider causes in addition to COVID-19, including other infections and therapy-related pneumonitis. […] For suspected or confirmed COVID-19, discuss temporary cessation of cancer therapy with a relevant specialist. […] Communicate treatment modifications, and review once health service capacity allows. […] Discuss and document goals of care, and involve palliative care services in contingency planning. […] Australasian Leukaemia and Lymphoma Group; Australasian Lung Cancer Trials Group; Australian and New Zealand Children’s Haematology/Oncology Group; Australia and New Zealand Society of Palliative Medicine; Australasian Society for Infectious Diseases; Bone Marrow Transplantation Society of Australia and New Zealand; Cancer Council Australia; Cancer Nurses Society of Australia; Cancer Society of New Zealand; Clinical Oncology Society of Australia; Haematology Society of Australia and New Zealand; National Centre for Infections in Cancer; New Zealand Cancer Control Agency; New Zealand Society for Oncology; and Palliative Care Australia. 2020-05-31
32401361 3 People’s Hospital of Jianghan University for a second treatment in March 2020. 2020-05-13
32401373 Covid-19 currently has no known treatment or a vaccine. 2020-05-13
32401405 The antimalarial drug hydroxychloroquine (HCQ) has long been used as a disease-modifying antirheumatic drug for the treatment of several inflammatory rheumatic diseases. 2020-05-13
32401442 The actual consensus is to continue the treatment with RAAS inhibitors, abrupt withdrawal, especially in patients with cardiac or renal conditions, being hazardous in terms of cardiovascular outcomes, except in patients hospitalized in intensive care with hemodynamic instability. 2020-05-18
32401611 The designed strategy represents a potential treatment to reduce the overall viral load in the lungs and to help the immune system to successfully stave off the infection. 2020-05-20
32401686 In the context of broad principles, issues including risks of treatment, principles of prioritizing resources, treatment of elderly patients, and psychosocial impact are discussed. […] Detailed treatment advice and options are given at a tumor stream level. […] We must maintain care for patients with cancer as best we can and recognize that COVID-19 poses a significant competing risk for death that changes conventional treatment paradigms. 2020-05-13
32401715 Effective antiviral therapy is important for tackling the coronavirus disease 2019 (COVID-19) pandemic. […] The median number of days from symptom onset to start of study treatment was 5 days (IQR 3-7). […] The combination group had a significantly shorter median time from start of study treatment to negative nasopharyngeal swab (7 days [IQR 5-11]) than the control group (12 days [8-15]; hazard ratio 4·37 [95% CI 1·86-10·24], p=0·0010). […] Early triple antiviral therapy was safe and superior to lopinavir-ritonavir alone in alleviating symptoms and shortening the duration of viral shedding and hospital stay in patients with mild to moderate COVID-19. […] Future clinical study of a double antiviral therapy with interferon beta-1b as a backbone is warranted. 2020-05-31
32401931 Besides, we briefly describe promising treatment strategies recognized until this moment. […] Currently, there is no effective treatment and fast diagnosis is still a challenge. 2020-05-19
32402056 To describe the characteristics, treatment, and outcomes of recipients of HT with COVID-19. […] Secondary measures included patient characteristics, laboratory analyses, changes to immunosuppression, and treatment administered for COVID-19. […] Twenty-two participants (79%) were admitted for treatment, and 7 (25%) required mechanical ventilation. […] Treatment of COVID-19 included hydroxychloroquine (18 patients [78%]), high-dose corticosteroids (8 patients [47%]), and interleukin 6 receptor antagonists (6 patients [26%]). 2020-05-20
32402088 Finally, we discuss measures to implement augmented care in care homes, including treatment with oxygen and subcutaneous fluids, and the frameworks which will be required if these are to be sustainable. 2020-05-29
32402090 Further research is needed focusing on the effect of existing liver-related comorbidities on treatment and outcome of COVID-19. 2020-05-13
32402130 Remdesivir has emerged as a promising treatment for SARS-Co-V-2 infection yet published clinical pharmacology and drug interaction studies are limited. 2020-05-13
32402532 In this context, the allocation of resources or the prioritization of treatment become crucial elements, and it is important to have an ethical reference framework to be able to make the necessary clinical decisions. […] For this, a process of narrative review of the evidence has been carried out, followed by a unsystematic consensus of experts, which has resulted in both the publication of a position paper and recommendations from SEMICYUC itself, and the consensus between 18 scientific societies and 5 institutes/chairs of bioethics and palliative care of a framework document of reference for general ethical recommendations in this context of crisis. 2020-05-16
32402766 What is urgently needed is an efficient pharmacological treatment for the treatment of severe cases. […] Theoretically, CQ and HCQ could thus be effectively used in the treatment of SARS-CoV pneumonia. […] From a pharmacological standpoint, however, the major problems of oral treatment with these drugs are possible severe side effects and toxicity. […] Empirical data on self-medication with a one-week aerosol application by two of the authors is presented. 2020-05-26
32402856 Despite previous outbreaks of SARS-CoV and the related MERS-CoV in recent years, neither a vaccine nor any other medication for an effective treatment are currently available. […] Endo-lysosomal two-pore cation channels have now emerged as potential novel targets for SARS-CoV treatment. 2020-05-19
32403153 The patient complained of prolonged fever and coughs for 7 days which had not improved after oral treatment with sultamicillin for 5 days, prescribed by the patient’s general practitioner. […] Suspecting a possible secondary bacterial infection at the beginning, intravenous antibiotic treatment with ampicillin/sulbactam was initiated. […] Due to clinical recovery antiviral therapy was not performed after confirming the diagnosis. 2020-05-13
32403202 Emergency rooms are inundated, and intensive care units are besieged with COVID-19 patients. 2020-05-13
32403242 With intensive care units operating at maximum capacity and such staggering mortality rates reported, it is imperative during this time-sensitive COVID-19 outbreak to identify patients with an increased risk of adverse outcomes and/or myocardial injury. 2020-05-19
32403255 The mechanism of liver injury is poorly understood and may result as a consequence of viral hepatitis, systemic inflammatory response, gut barrier and microbiome alterations, intensive care treatment or drug toxicity. 2020-05-14
32403895 Although the prevention and treatment of COVID 19 has become the priority for the majority of the population, most medical professionals are facing the challenge of balancing the management of this pandemic and treating patients with other diseases. 2020-05-14
32403946 Outcome from the infection were compared with infected noncancer patients. Results: Twenty patients (80%) were treated with antiviral therapy and hydroxychloroquine and five (20%) received hydroxychloroquine alone. 2020-05-16
32403995 Most recently SARS-CoV-2 virus (causing COVID-19) has led to a pandemic with no successful therapeutics. 2020-05-22
32404126 This study aims to assess the effectiveness of delivering Solution Focused Brief Therapy (SFBT) through telecommunication with a group of adolescents who present anxiety symptoms during the COVID-19 outbreak. […] We hypothesize that participants who are randomly assigned to receive 2-4 sessions of Solution Focused Brief Therapy would have better clinical outcomes than participants who are in the waitlist group. 2020-05-15
32404189 So far, there is no effective vaccine protection or proven therapy available against the SARS-CoV-2 virus. 2020-05-15
32404205 However, a subset of the chiropractic profession has claimed that spinal manipulative therapy (SMT) is clinically effective in improving one’s immunity, despite the lack of supporting scientific evidence. 2020-05-16
32404219 As in other European countries, the current Covid-19 pandemic has not only massively restricted normal life in Germany, it is also having a significant effect on medical treatment, particularly in the areas of child and adolescent psychiatric care, as well as on university teaching. 2020-05-14
32404232 Restrictions on usual activities are likely to induce mental stress especially among those who are autistic leading to an escalation in challenging behaviours, risk of placement breakdown, and increased the use of psychotropic medication. 2020-05-14
32404302 The infection can be life threatening and require intensive care treatment. […] Modified diagnostic and treatment algorithms are proposed to adapt evidence-based protocols for this unprecedented challenge. 2020-05-14
32404451 No specific therapy is available and supportive care with rest, fluids, and antipyretics for children is the recommended approach. […] Antiviral and immunomodulatory treatment is not recommended at this time for otherwise healthy children, and corticosteroids should also not be used. 2020-05-15
32404473 Accurate diagnoses of cases is key in managing the pandemic by identification, isolation and treatment of patients and defining the epidemiology of the virus. 2020-05-14
32404477 Our results highlight the promise of antibody-based therapeutics and provide a structural basis for rational vaccine design. 2020-05-22
32404514 Here, we highlight (i) the lessons that have been learnt so far and how they will benefit reducing the impact of COVID-19 disease and (ii) an update on the status of drug treatment and vaccine development to prevent COVID-19 and potential future related pandemics. […] Drugs are urgently needed for both prophylaxis and the treatment of severely ill patients; however, no proven effective therapies for SARS-CoV-2 currently exist. […] A number of drugs that have been approved for other diseases are being tested for the treatment of COVID-19 patients, but there is an absence of data from appropriately designed clinical trials showing that these drugs, either alone or in combination, will prove effective. […] This review summarizes the lessons learnt so far from the COVID-19 pandemic, examines the evidence regarding the drugs that are being tested for the treatment of COVID19, and describes the progress made in efforts to develop an effective vaccine. 2020-05-20
32404651 : The COVID19 crisis has created many additional challenges for patients with opioid use disorder, including those seeking treatment with medications for OUD. […] Some of these challenges include closure of substance use treatment clinics, focus of emergency departments on COVID-19 patients, social distancing and shelter in place orders affecting mental health, bystander overdose rescue, threats to income and supply of substances for people who use drugs. 2020-05-22
32404652 : During the COVID-19 pandemic, many addiction treatment and harm reduction organizations have had to reduce their hours and services for people with substance use disorders, placing these individuals at increased risk of death. […] In order to address restricted treatment access during COVID-19, guidance from the Substance Abuse Mental Health Services Administration, the US Drug Enforcement Administration, and the US Department of Health and Human Services has allowed for use of audio-only telehealth encounters for buprenorphine induction without requiring an in-person evaluation or video interface. […] In this new regulatory environment, we established the Rhode Island Buprenorphine Hotline, a phone hotline which functions as a “tele-bridge” clinic where people with moderate to severe opioid use disorder can be linked with a DATA 2000 waivered provider who can provide an initial assessment and, if appropriate, prescribe buprenorphine for unobserved induction and linkage to outpatient treatment. […] In this correspondence we briefly share our experience developing this common sense approach to addressing the complex problem of access to treatment only now permissible due to regulatory changes during COVID-19. 2020-05-22
32404780 It is necessary to extend isolation time, increase the number of nucleic acid detections and conduct early symptomatic treatment for children with both COVID-19 and additional health problems. 2020-05-14
32404786 All 25 children with laboratory-confirmed 2019-nCoV infection by real-time reverse transcription-PCR (RNA-PCR) were admitted from the 4 designated treatment hospitals of 2019-nCoV in Chongqing from January 19 to March 12, 2020. […] There was no significant difference of RNA turning negative between the groups of interferon, interferon plus ribavirin and interferon plus lopinavir or ritonavir treatment. 2020-05-14
32404975 This pandemic poses unprecedented stress on the health care system including programs performing allogeneic and autologous hematopoietic cell transplantation (HCT) and cellular therapy such as with CAR T cells. 2020-05-16
32405058 The current COVID-19 pandemic challenges oncologists to profoundly re-organize oncological care in order to dramatically reduce hospital visits and admissions and therapy-induced immune-related complications without compromising cancer outcomes. 2020-05-18
32405071 Eligible patients using renin-angiotensin system blockers (ACEI/ARBs) with a confirmed diagnosis of COVID-19 will be randomized to a strategy of continued ACEI/ARB treatment versus temporary discontinuation for 30 days. […] BRACE CORONA will evaluate whether the strategy of continued ACEI/ARB therapy compared with temporary discontinuation of these drugs impacts clinical outcomes among patients with COVID-19. 2020-05-16
32405079 Novel coronavirus infectious disease (COVID-19) has been spreading worldwide, and tracking laboratory indexes during the diagnosis and treatment of patients with severe COVID-19 can provide a reference for patients in other countries and regions. […] We closely tracked the epidemiological history, diagnosis and treatment process, as well as dynamic changes in routine blood indicators, of a severe COVID-19 patient who was hospitalized for 26 days. […] Dynamic changes in routine blood parameters might be helpful for the prognosis of COVID-19 patients and evaluation of the treatment effect. 2020-05-31
32405080 Monitoring T cell changes has important implications for the diagnosis and treatment of severe patients who may become critically ill.  2020-05-31
32405088 Guideline directed drug therapy including ACEI/ARB/ARNI is to be continued in patients with pre-existing HF. 2020-05-16
32405101 In this prospective study consecutive patients hospitalized in non-intensive care units with diagnosis of COVID-19 pneumonia and D-dimer > 1000 ng/ml were screened for asymptomatic DVT with complete compression doppler ultrasound (CCUS). 2020-05-29
32405115 The COVID-19 pandemic has brought major challenges to healthcare systems and public health policies globally, as it requires novel treatment and prevention strategies to adapt for the impact of the pandemic. […] Moreover, social and economic changes caused by the pandemic, along with the traditional difficulties regarding treatment access and adherence - will certainly worsen during this period, therefore aggravate their condition. […] In that sense, specific strategies for prevention and treatment must be discussed. health care professionals dealing with SUD must be aware of the risks and challenges they will meet during and after the COVID-19 outbreak. 2020-05-22
32405117 SARS-CoV-2-caused COVID-19 cases are growing globally, calling for developing effective therapeutics to control the current pandemic. 2020-05-23
32405152 Compliance with highest level of personal protection and restriction of treatment to emergency cases is recommended during the outbreak. 2020-05-14
32405156 Hydroxychloroquine (CLQ-OH)/azithromycin (ATM) combination therapy is currently being tested for the treatment of COVID-19, with promising results. […] This molecular mechanism may explain the beneficial effects of CLQ-OH/ATM combination therapy in patients with COVID-19. 2020-05-22
32405160 Patients admitted before March 13th (n=23) were prescribed the standard therapy (hydroxychloroquine, lopinavir and ritonavir) and were considered controls. 2020-05-16
32405164 Yet, the World Health Organization officially announced that there is still at present no recommended anti-nCoV vaccine for subject at-risk, nor treatment for patients with suspected or confirmed nCoV, let alone 2019-nCov. […] It is therefore timely and critical to propose new possible and practical approaches for preventive interventions for subjects at-risk, and for treatment of patients afflicted with 2019-nCov-induced disease (Corona Virus Disease 2019; COVID-19) before the present situation explodes into a worldwide pandemic. 2020-05-16
32405226 It has been used for centuries for the treatment of fever and chills, and has been recently approved for the treatment of malaria due to its endoperoxidase properties. […] In this review, we aim to provide a comprehensive update of the current knowledge of the effects of artemisinins in relation to respiratory diseases to identify gaps that need to be filled in the course of repurposing artemisinins for the treatment of respiratory diseases. […] In addition, we postulate whether artemisinins can also be repurposed for the treatment of COVID-19 given its anti-viral and anti-inflammatory properties. 2020-05-23
32405229 The evaluation of the treatment of these comorbidities at baseline and during COVID-19 is scarce and the results are conflicting. […] The aim of this review article was to summarize the prevalence of hypertension and CVD in patients with COVID-19, their influence on the outcome and the effect of treatment of hypertension and CVD in COVID-19 patients. 2020-05-23
32405236 This is a discussion and comparison of the virus structures, transmission characteristics, clinical symptoms, diagnosis, pathological changes, treatment and prevention of the two kinds of viruses, CoVs and IAVs. 2020-05-23
32405418 None of the infected nurses were hospitalized and all of them preferred to be quarantine at home and receive the necessary care and treatment (Oseltamivir, Azithromycin and Kaletra. […] This study also reported that receiving the necessary care and treatment at home was a good experience for nurses that can be used in some cases. 2020-05-14
32405421 Repurposing broad-spectrum antivirals is an immediate treatment opportunity for 2019 coronavirus disease (COVID-19). […] Favipiravir is an antiviral previously indicated for influenza and Ebola, which has shown some promise in early trials for treatment of COVID-19. […] Favipiravir may be safe and tolerable in short-term use, but more evidence is needed to assess the longer-term effects of treatment. 2020-05-16
32405422 There were no teratogenic concerns, but the evidence base was very limited.Based on a weighted-mean cost of US $61/kg, a 14-day course of treatment with nitazoxanide 500 mg BD would cost $1.41. […] We estimate that it would be possible to manufacture nitazoxanide as generic for $1.41 for a 14-day treatment course at 500 mg BD, up to $4.08 at 1100 mg TDS. […] If efficacy against SARS-CoV-2 is demonstrated in clinical studies, nitazoxanide may represent a safe and affordable treatment in the ongoing pandemic. 2020-05-16
32405423 Costs of production ranged between $0.30 and $31 per treatment course (10-28 days). […] Estimations for the minimum production costs can strengthen price negotiations and help ensure affordable access to vital treatment for COVID-19 at low prices globally. 2020-05-16
32405454 The patient referred to treatment clinic for COVID-19 in Imam Reza hospital of Tabriz (Iran) after having flu-like symptoms. […] Lopinavir/ritonavir (200mg/50mg) two tablet tow times, Ribavirin 200mg every six hours, and Oseltamivir 75mg tow times were given for the treatment of COVID-19. […] The medications used for treatment of pneumonia were Meropenem, Ciprofloxacin, Vancomycin. 2020-05-30
32405509 We discuss the current knowledge gaps driven by questions around the quality and consistency of clinical trial results, patient selection, diagnostic methodologies, use of suppressive antibiotic therapy, and methods for adverse event reporting. […] We provide specific recommendations for future trial designs of FMT to provide improved quality of the clinical evidence to better inform treatment guidelines. 2020-05-14
32405620 Since the World has been facing the COVID-19 pandemic, special attention has been taken concerning cancer patients; related to their immunosuppression status, adding risk for more aggressive COVID-19 and mortality, but also concerns about the access and the quality of care in cancer therapy. […] In essence, they are immunosuppressed in different intensities during their treatment. […] Most of them are elderly and all of them require long-term therapy, with prolonged contact with the health care system, possibly including a stem cell transplant during the treatment. 2020-05-16
32405622 This potential utilization of DPP4 as a binding target for SARS-CoV-2 may offer novel insight into the viral pathogenesis and help the surveillance and therapeutics strategy for meeting the challenge of COVID-19. 2020-05-29
32405641 The infection can be life threatening and require intensive care treatment. […] Modified diagnostic and treatment algorithms are proposed to adapt evidence-based protocols for this unprecedented challenge. 2020-05-20
32405780 With the continuous spread of the new coronavirus pneumonia epidemic in even the world, prevention and treatment of the disease have become urgent tasks. […] In addition to being controlled through effective isolation, we need a rapid response from the healthcare and biotechnology industries to accelerate drug treatment research. […] By reviewing the currently available literature published at home and abroad, we summarize the current research progress of drug treatment during the epidemic period. […] At present, the drugs that can be used for treatment mainly include antiviral drugs, antimalarials, glucocorticoids, plasma therapy, biological agents, and traditional Chinese medicine. […] The effectiveness and safety of drug therapy need to be confirmed by more clinical studies. 2020-05-19
32405783 The management of mild disease is supportive, while very many immunomodulatory and antiviral therapies are being investigated for the treatment of severe disease. 2020-05-16
32405877 At present, anti-IL-6, antiviral therapy, convalescent plasma, hydroxychloroquine, and azithromycin among others are being investigated as potential treatments for COVID-19. […] As the disease etiology and precise therapeutic interventions are still not definitively defined, we wanted to review the roles that complement and the contact system may have in either the treatment or pathogenesis of the disease. 2020-05-25
32405882 During the current viral outbreak, physicians should not neglect the possibility of other diseases that represent neurological emergencies and require immediate recognition and treatment. 2020-05-16
32405955 Older patients with CA and those with immune-mediated ataxias on immunosuppressive medication are potentially at high risk of developing serious complications of the infection, although it is also possible that immunosuppressive agents may provide a defense against cytokine storm. […] As the disruption of social patterns and healthcare delivery in response to the crisis continues, interruption of rehabilitation, speech and language therapy, and face-to-face consultations threatens to have a negative impact on the course and well-being of CA patients. 2020-05-16
32405974 Currently, the number of severe cases worldwide has increased rapidly, but the experience in the treatment of infected patients is still limited. […] Given the lack of specific antiviral drugs, multi-organ function support treatment is important for patients with COVID-19. […] This paper provides a clinical reference and a new strategy for the optimal treatment of COVID-19 worldwide. 2020-05-15
32406115 And, although not all of the microbially relevant infrastructure will be within reach of schools, there is usually access to a market, local food store, wastewater treatment plant, farm, surface water body, etc., all of which can provide opportunities to explore microbiology in action. 2020-05-16
32406317 It is noteworthy that Viomycin showed higher -CDocker energy as compared to the drugs currently under clinical trial for SARS-CoV-2 treatment viz. Ritonavir and Lopinavir. 2020-05-25
32406348 Introducing a mindfulness and meditation practice during this pandemic has the potential to complement treatment and is a low cost beneficial method of providing support with anxiety for all. 2020-05-14
32406369 It is extremely important to understand this phenomenon, as individuals with intermittent virus shedding could be falsely identified as reinfected and may benefit from ongoing antiviral treatment. 2020-05-14
32406381 The timely and accurate diagnosis of infection with severe acute respiratory syndrome (SARS) coronavirus 2 (SARS-CoV-2), the cause of coronavirus disease 2019 (COVID-19), remains the cornerstone of efforts to provide appropriated treatment for patients, to limit further spread of the virus and ultimately to eliminate the virus from the human society. […] We focus this article on (a) developments for improvement of diagnosis of specific SARS-CoV-2 virus, (b) laboratory changes in the immunologic and coagulation system, (c) therapeutic options for anticoagulant treatment of seriously affected patients and (d) on the perspectives through improvement of diagnostic and therapeutic medical procedures. 2020-05-14
32406395 As there is no vaccination and proper medicine for treatment, the recent pandemic caused by COVID-19 has drawn attention to the strategies of quarantine and other governmental measures, like lockdown, media coverage on social isolation, and improvement of public hygiene, etc to control the disease. 2020-05-16
32406512 Patients on these medications should not stop their medication prophylactically. 2020-05-29
32406687 Currently, the new coronavirus disease 2019 (COVID-19) is a global pandemic without any well-calibrated treatment. 2020-05-23
32406853 An important group who will be confronted with the treatment of COVID19 positive patients are HCP during (semi) acute surgery. 2020-05-14
32406873 In December 2019, in the city of Wuhan, in the Hubei province of China, treatment-resistant cases of pneumonia emerged and spread rapidly for reasons unknown. 2020-05-19
32406927 Convalescent plasma and hyperimmune immunoglobulin may reduce mortality in patients with respiratory virus diseases, and are currently being investigated in trials as a potential therapy for coronavirus disease 2019 (COVID-19). […] OBJECTIVES: To assess whether convalescent plasma or hyperimmune immunoglobulin transfusion is effective and safe in the treatment of people with COVID-19. […] Effectiveness of convalescent plasma for people with COVID-19 The following reported outcomes could all be related to the underlying natural history of the disease or other concomitant treatment, rather than convalescent plasma. […] We do not know whether convalescent plasma therapy affects mortality (very low-certainty evidence). […] Time to discharge from hospital Six studies reported time to discharge from hospital for at least some participants, which ranged from four to 35 days after convalescent plasma therapy. […] We are very uncertain whether or not convalescent plasma therapy affects the risk of moderate to severe adverse events (very low-certainty evidence). […] We are very uncertain whether or not convalescent plasma therapy affects the risk of serious adverse events (very low-certainty evidence). […] We identified very low-certainty evidence on the effectiveness and safety of convalescent plasma therapy for people with COVID-19; all studies were at high risk of bias and reporting quality was low. 2020-05-19
32406985 Herein, we report a case of successful treatment of SARS-CoV-2 induced inflammatory syndrome by utilization of the interleukin-6 receptor antagonist (IL-6Ra) tocilizumab. 2020-05-14
32407051 However, the efficacy of hyper-immune/convalescent plasma treatment for severe infectious diseases is still controversial. […] The optimal dose and time point, as well as the clinical benefit of hyper- immune/convalescent plasma therapy, needs further investigation in larger well-controlled trials. 2020-05-14
32407142 Bad advice can lead to tragedy, such as death from taking an unproven medication.1 Now, more than ever, public health policies should be based on the best available evidence. 2020-05-14
32407178 The challenge of social distancing, providing care for those infected by COVID-19, continuing appropriate treatment of time-sensitive diseases, and the looming threat of health care worker infections required swift planning and restructuring of training programs. 2020-05-14
32407289 It is also recommended to increase and expand resources of intensive care units including respirators, increase the capacity and the number of trained health staff in the area of public health and epidemiology, ensure continued provision of essential public health programs and mobilize the resources of non-governmental sector and donors to provide services for refugees and vulnerable populations. 2020-05-14
32407459 We conducted a systematic review and meta-analysis of all published studies up to March 15, 2020 which reported COVID-19 clinical features and/or treatment outcomes. 45 studies reporting 4203 patients were included. […] Treatment with lopinavir-ritonavir showed no significant benefit in mortality and ARDS rates. 2020-05-29
32407539 Many small stand-alone trials and observational studies of single-agent interventions are currently running or in planning; many of these will likely not deliver robust results that could support regulatory and patient-level treatment decisions. […] We here discuss actions that all stakeholders in the clinical trial ecosystem need to take to ensure that the window of opportunity during this pandemic will not shut, both for patients in need of treatment and for researchers to conduct decision-relevant clinical trials. 2020-05-14
32407543 COVID-19 pandemic is an emerging new human disease, where no vaccines, or monoclonal antibodies (mAbs), or drugs are currently available for therapy. 2020-05-14
32407609 The patient with older age and higher comorbidities failed to recover from the viral illness that has no definitive treatment. 2020-05-14
32407719 One patient died after withdrawal of life-sustaining therapy because of metastatic cancer. 2020-05-30
32407772 Transparent and clear communication is crucial, coupled with dedication to provide the best possible care to patients, including palliative care. 2020-05-16
32407884 There is no known effective therapy for patients with COVID-19. […] We reviewed ECG tracings from baseline and until 3 days after completion of therapy to determine the progression of QTc and incidence of arrhythmia and mortality. […] Seven patients required premature termination of therapy. […] This risk mandates careful consideration of HY/AZ therapy in lights of its unproven efficacy. 2020-05-16
32407959 SARS-CoV-2 is causing an increasing number of deaths worldwide because no effective treatment is currently available. […] Remdesivir has shown in vitro activity against coronaviruses and is a possible antiviral treatment for SARS-CoV-2 infection. 2020-05-31
32408070 Currently, drug repurposing is an alternative to novel drug development for the treatment of COVID-19 patients. 2020-05-26
32408155 Fingolimod is used for immune therapy in patients with multiple sclerosis. […] Long-term treatment is associated with a small increase in the risk of herpes virus reactivation and respiratory tract infections. […] Patients with coronavirus disease 2019 (COVID-19) under Fingolimod treatment have not been described. […] We report a 57-year old female patient with a relapsing remitting multiple sclerosis under fingolimod treatment who experienced a severe COVID-19 infection in March 2020 (Extended Disability Status Scale: 2.0). […] Having peripheral lymphopenia typical for fingolimod treatment (total lymphocytes 0.39/nL [reference range 1.22-3.56]), the patient developed bilateral interstitial pneumonia with multiple ground-glass opacities on chest CT. […] Fingolimod medication was stopped. 2020-05-26
32408156 These results will provide a helpful reference for diagnosis and clinical treatment of COVID-19 patients. 2020-05-29
32408336 However, treatment options and a cellular understanding of SARS-CoV-2 infection are lacking. […] Furthermore, our findings provide insight for the development of therapy options for COVID-19. 2020-05-14
32408338 A suitable small animal model is needed to support vaccine and therapy development. 2020-05-14
32408391 A recent paper by Tang et al. [2] in this journal reported that heparin treatment reduced mortality of COVID-19 patients with elevated D-dimer; similar preliminary results have been reported elsewhere [3]. 2020-05-14
32408508 COVID-19 patients management requires availability of sufficiently large number of Intensive Care Units (ICUs) beds. 2020-05-19
32408730 Patients receiving hemodialysis are more vulnerable to viral transmission because their immune functions are impaired and they receive treatment within a narrow space. […] Calling on previous experience with Middle East Respiratory Syndrome during the 2015 outbreak, the joint committee of the Korean Society of Nephrology and the Korean Society of Dialysis Therapy quickly formed a COVID-19 task force team to develop a manual before the first index case was diagnosed in the hemodialysis unit. […] The areas of infection control covered by these guidelines include standard precautions, performing dialysis therapy for confirmed or suspected cases, performing cohort isolation for contact patients, and disease monitoring and contact surveillance. 2020-05-15
32408842 Care for patients with cancer is particularly important given increased infection rates and worse outcomes from COVID-19 in this patient population, as well as potential adverse outcomes if treatment pathways need to be compromised. […] Specifically, we highlight challenges related to safe handling of hazardous drugs and maintaining high-quality medication safety standards that have impacted various stakeholders. 2020-05-15
32409150 Chloroquine or hydroxychloroquine (chloroquine) plus azithromycin is considered as therapy for COVID-19. […] We included autoimmune disease patients aged ≥18 years initiating azithromycin or amoxicillin for ≥5 days during chloroquine treatment. […] Covariates were adjusted using stabilized inverse probability treatment weighting. 2020-05-18
32409298 The COVID-19 pandemic has created major insecurities regarding whether we can and should maintain the current standards of diagnosis and treatment and access to care for patients with cancer. […] More than ever, it seems to be mandatory to adhere to evidence-based medicine and not to prescribe potentially toxic, notably immunsuppresssive systemic therapy where evidence for efficacy is low. 2020-05-16
32409433 Antivirals with evidence of clinical activity must be studied as treatment and prophylaxis for those at high risk for severe COVID-19. 2020-05-16
32409434 At this time, there is no clinical evidence to suggest that treatment with RAS inhibitors should be discontinued in stable patients with COVID-19. 2020-05-28
32409436 Treatment of COVID-19 for patients with underlying ILD or sarcoidosis may include hospital admission, possible drug treatment, caution with steroids, and avoidance of mechanical ventilation in acute exacerbation of ILD. 2020-05-15
32409438 At present, there are no firm guidelines for the treatment of COVID-19-related emotional distress. 2020-05-28
32409439 Anti-IL-6 drugs are being widely used experimentally and as off-label therapy for patients with COVID-19 who are sick and deteriorating but have a reasonable chance of recovering, but they are still unproven and unapproved for this use. 2020-05-15
32409440 Cardiac imaging should only be ordered if its benefits outweigh its risks, with anticipated changes in acute treatment and outcomes, and no suitable alternative of sufficient adequacy is available. 2020-05-15
32409486 Hydroxychloroquine at a dose of 600 mg/day within 48 hours of admission to hospital (treatment group) versus standard care without hydroxychloroquine (control group). […] Analyses were adjusted for confounding factors by inverse probability of treatment weighting. […] In the main analysis, 84 patients who received hydroxychloroquine within 48 hours of admission to hospital (treatment group) were compared with 89 patients who did not receive hydroxychloroquine (control group). […] In the weighted analyses, the survival rate without transfer to the intensive care unit at day 21 was 76% in the treatment group and 75% in the control group (weighted hazard ratio 0.9, 95% confidence interval 0.4 to 2.1). […] Overall survival at day 21 was 89% in the treatment group and 91% in the control group (1.2, 0.4 to 3.3). […] Survival without acute respiratory distress syndrome at day 21 was 69% in the treatment group compared with 74% in the control group (1.3, 0.7 to 2.6). […] At day 21, 82% of patients in the treatment group had been weaned from oxygen compared with 76% in the control group (weighted risk ratio 1.1, 95% confidence interval 0.9 to 1.3). […] Eight patients in the treatment group (10%) experienced electrocardiographic modifications that required discontinuation of treatment. […] Hydroxychloroquine has received worldwide attention as a potential treatment for covid-19 because of positive results from small studies. 2020-05-19
32409501 Patients in the intensive care unit requiring therapy for glycemic control should be handled solely by intravenous insulin using exact dosing with a perfusion device. 2020-05-16
32409502 Compared with normal weight patients, those who were overweight had 1.84-fold odds of developing severe COVID-19 (odds ratio [OR] 1.84, 95% CI 0.99-3.43, P = 0.05), while those who were obese were at 3.40-fold odds of developing severe disease (OR 3.40, 95% CI 1.40-2.86, P = 0.007), after adjusting for age, sex, epidemiological characteristics, days from disease onset to hospitalization, presence of hypertension, diabetes, cardiovascular disease, chronic obstructive pulmonary disease, liver disease and cancer, and drug used for treatment. […] As the severe acute respiratory syndrome coronavirus 2 may continue to spread worldwide, clinicians should pay close attention to obese patients, who should be carefully managed with prompt and aggressive treatment. 2020-05-15
32409561 Multicentre, open label, randomised controlled trial. 16 government designated covid-19 treatment centres in China, 11 to 29 February 2020. 150 patients admitted to hospital with laboratory confirmed covid-19 were included in the intention to treat analysis (75 patients assigned to hydroxychloroquine plus standard of care, 75 to standard of care alone). […] Hydroxychloroquine administrated at a loading dose of 1200 mg daily for three days followed by a maintenance dose of 800 mg daily (total treatment duration: two or three weeks for patients with mild to moderate or severe disease, respectively). 2020-05-19
32409680 Early identification of possible hyperinflammation could be fundamental and should guide decision making regarding hospitalization, early respiratory support, and therapy with immunosuppression to improve mortality. 2020-05-16
32409832 This Viewpoint summarizes the strong scientific arguments supporting the use of alisporivir, a non-immunosuppressive analogue of cyclosporine A with potent cyclophilin inhibition properties that has reached Phase 3 clinical development, for the treatment of COVID-19. 2020-05-29
32410003 Insights in pathophysiological mechanisms of less severity in children could be important for devising therapeutics for high-risk adults and elderly. 2020-05-25
32410206 The following data were obtained from electronic medical records: demographics, medical history, exposure history, underlying comorbidities, symptoms, signs, laboratory findings, computer tomography scans, and treatment measures. […] The outcome of treatment indicated that in patients with the common-type COVID-19, interferon-α2b, but not novaferon, had some benefits, antibiotics treatment was not needed, and corticosteroids should be used cautiously. […] We observed some treatment benefits with interferon-α2b and corticosteroid therapies but not with novaferon and antibiotic treatment in our study population. 2020-05-25
32410245 After treatment, two patients met the standard and were discharged. 2020-05-15
32410319 We also call for guidelines for management and treatment as well as research to understand the epidemiology of coinfection This article is protected by copyright. 2020-05-15
32410413 To identify predictors of pulmonary fibrosis development by combining follow-up thin-section CT findings and clinical features in patients discharged after treatment for COVID-19. […] 10.0 days, p = 0.001), pulsed steroid therapy (11.0 days vs. […] 5.0 days, p < 0.001), and antiviral therapy (12.0 days vs.  2020-05-20
32410714 Of all the studied patients, 85 (37.6%) received invasive mechanical ventilation, including 14 (6.2%) treated with extracorporeal membrane oxygenation (ECMO) at the same time, 20 (8.8%) received noninvasive mechanical ventilation, and 24 (10.6%) received continuous renal replacement therapy. 2020-05-18
32410760 The two groups differed in disease incidence (group 1 vs group 2, 0·3 vs ten per month), mean age (3·0 vs 7·5 years), cardiac involvement (two of 19 vs six of ten), KDSS (zero of 19 vs five of ten), MAS (zero of 19 vs five of ten), and need for adjunctive steroid treatment (three of 19 vs eight of ten; all p<0·01). 2020-05-18
32410772 Vaccines for this deadly virus are currently under development and many drugs used for other indications have been repurposed and investigated for prophylaxis and treatment of COVID 19. […] As per SOLIDARITY trial by WHO, some of the most promising candidates include chloroquine phosphate and hydroxychloroquine which are anti-malarial medications, Remdesivir, Lopinavir-Ritonavir combination with or without interferon which are anti-HIV drugs and convalescent plasma therapy. […] The situation is still evolving and hence there is yet no definitive therapy but to conclude the use of repurposed medications can be a boon till a definitive therapy and vaccines are developed. 2020-05-26
32410912 Brachytherapy is one of the important treatment modalities for some subsites of cancers. […] Brachytherapy provides an opportunity for the patients and the physicians during the COVID-19 outbreak; it can retain the patient’s chance for treatment while limiting the chance of exposure and transmission of infection. 2020-05-16
32410913 The aim of this article is to provide basic consolidated guidance and checklists to clinicians in the neonatal intensive care units in key aspects of preparation needed to counter exposure or infection with COVID-19. 2020-05-18
32411313 Here, we report on the treatment of eight severe COVID-19 pneumonia patients– seven hospitalized in intensive care units (ICUs) in Greece and one non-ICU patient in the Netherlands– with the interleukin-1 receptor antagonist Anakinra. […] At the end-of-treatment, ICU patients had less need for vasopressors, significantly improved respiratory function and lower HScore. 2020-05-28
32411315 Current emergency unit asthma guidelines recommend bronchodilators be administered by metered dose inhaler (MDI) and spacer for mild-moderate asthma and include it as a choice even in severe asthma, but many emergency units continue to prefer nebulised therapy for patients who urgently require beta-agonists. […] The utilization of nebulised therapy potentially increases the risk of aerosolization of the coronavirus. […] Since nosocomial transmission of respiratory pathogens is a major threat in the context of the SARS-CoV-2 pandemic, use of nebulised therapy is of even greater concern due to the potential increased risk of infection spread to nearby patients and health-care workers. […] We propose a risk stratification plan that aims to avoid nebulised therapy, when possible, by providing an algorithm to help better delineate those who require nebulised therapy. […] Furthermore, expedient treatment of patients with high dose MDI therapy augmented with more rapid initiation of systemic therapy may help ensure patients are less likely to deteriorate to the stage where nebulisers are required. 2020-05-15
32411566 Yet, they have also been utilized in the treatment of various pulmonary disorders with vasoconstriction. […] Patients treated with a CCB were significantly more likely to survive than those not treated with a CCB: 12 (50%) survived and 12 expired in the CCB group vs. six (14.6%) that survived and 35 (85.4%) that expired in the No-CCB treatment group (P<.01; p=0.0036). […] Only one patient (4.2%) was intubated in the CCB group whereas 16 (39.0%) were intubated in the No-CCB treatment group (P<.01; p=0.0026). […] Including either nifedipine or amlodipine in medication regimens for elderly patients with hypertension hospitalized for COVID-19 may be considered. 2020-05-18
32411619 The availability of pathogen-specific treatment options for respiratory tract infections (RTIs) increased the need for rapid diagnostic tests. […] In this review, we summarize recently published characteristics of POCTs and discuss their implications for the treatment of RTIs. 2020-05-19
32411770 Here, we attempt to describe the clinical characteristics and treatment experiences of discharged cases from Taizhou, China. […] All patients received combined antiviral treatment on admission, including β-interferon, lopinavir/tonavir, Abidol and oseltamivir. […] All patients with severe conditions received gamma globulin and hormone therapy. […] Early therapy and comprehensive therapy are key to the outcome for patients with COVID-19-infected pneumonia, especially for those with severe pneumonia. 2020-05-18
32411941 We propose several suggestions related to treatment of COVID-19 pneumonia with chloroquine/hydroxychloroquine that we think must be taken into consideration to fit the evolving situation of the pandemic in Greece. 2020-05-16
32412159 We performed a multicenter nationwide observational study within the Swiss Transplant Cohort Study (STCS) to describe the epidemiology, clinical presentation, treatment and outcomes of the first microbiologically documented SARS-CoV-2 infection among SOT recipients. 2020-05-15
32412310 Prostate cancer is one of the most common cancers among men and raises particular interest during the pandemic as recent reports show that the TMPRSS2 (and other serine proteases), which facilitate the entry, replication and budding of the virion from a cell, can be inhibited using androgen deprivation therapy. 2020-05-15
32412509 To date, there is no specific therapy for SARS-CoV-2 infection. 2020-05-26
32412515 Non-invasive mechanical ventilation and high-flow oxygen therapy are not recommended due to the generation of aerosol (associated with risk of viral spread among health personnel), and neither is extracorporeal membrane oxygenation or the use of steroids. […] So far, there is no specific antiviral treatment for patients with COVID-19, and neither are there results of controlled trials supporting the use of any. 2020-05-15
32412811 This descriptive investigation was undertaken at three oncology units to report queries, needs, and fears related to severe acute respiratory syndrome coronavirus 2 (COVID-19) of patients with cancer and to avoid uncontrolled treatment delays or withdrawal, behavioral mistakes, and panic. 2020-05-22
32412891 A number of pharmacologic regimens, including hydroxychloroquine-azithromycin, antiviral therapy (eg, remdesevir), and anti-IL-6 agents (e.g., toclizumab), have been highlighted by investigators over the course of the pandemic, based on the therapy’s potential to interrupt the viral life-cycle of SARS-CoV-2 or preventing cytokine storm. […] At present, there have been no conclusive series of reproducible randomised clinical trials demonstrating the efficacy of any one drug or therapy for COVID-19. […] COVID-19 positive patients (n=5) at a single institution received hyperbaric oxygen therapy (HBOT) between 13 and 20 April 2020. […] Larger studies are likely to define the role of HBOT in the treatment of this novel disease. 2020-05-16
32412918 The undistinguishable similarity of the genomic sequences of Severe Respiratory Syndrome (SARS)-CoV, Middle East Respiratory Syndrome (MERS)-CoV, and Bat SARS-CoV-bat-SL-CoVZC45 and bat-SL-CoVZXC21-to nCoV-2019 has facilitated the process of identifying primary treatment measures. 2020-05-15
32412931 In the setting of COVID-19, opioid use disorder treatment paradigms are being disrupted, including the fact that methadone clinics are scrambling to give “take-home” doses where they would typically not. […] The rapid transition away from in-person examination, dosing and group therapy in an era of social isolation calls for adjustments to clinical practice, including emphasizing patient-provider communication, favoring new inductees on buprenorphine and leveraging technology to optimize safety of medication treatment. 2020-05-20
32413276 The worldwide spread of COVID-19 highlights the need for an efficient approach to rapidly develop therapeutics and prophylactics against SARS-CoV-2. 2020-05-18
32413300 Therapeutics including antivirals, immunomodulators, and vaccines are in development. 2020-05-19
32413527 Information technologies, treatment prioritization and implementation of hypofractionation and protection procedures allowed balancing between cancer patient care and patient/healthcare workers safety. 2020-05-31
32413554 The COVID-19 pandemic has broadly disrupted biomedical treatment and research including non-invasive brain stimulation (NIBS). 2020-05-29
32413608 Therefore, this study investigated the impact of the current pandemic situation on HIV care and continuity of antiretroviral treatment (ART) supplies in CEE countries. 2020-05-31
32413619 Our findings demonstrate significant physicochemical differences between Lentinan extracts, which produce differential in vitro immunomodulatory and pulmonary cytoprotective effects that may also have positive relevance to candidate COVID-19 therapeutics targeting cytokine storm. 2020-05-31
32413736 Essential elements that process SARS-CoV2 cell entry and specific characteristics that allow SARS-CoV2 to escape the immune system have the potential as targets for COVID-19 therapy. 2020-05-28
32414384 By plotting the number of patients receiving treatment against day, it is clear that implementing “pairing assistance” is a turning point in China’s fight against epidemics. 2020-05-20
32414390 To regulate the emergency treatment of trauma patients during the outbreak, we drafted this paper from a trauma surgeon perspective according to practical experience in Wuhan. 2020-05-20
32414626 The coronavirus disease 2019 (COVID-19) pandemic is leading to delays in the treatment of many urologic cancers. […] To provide a contemporary picture of the risks from delayed treatment for urologic cancers to assist with triage. […] Treatment of most patients with intermediate- and high-risk PCa can be deferred 3-6 mo without change in outcomes. […] With radiotherapy, neoadjuvant androgen deprivation therapy (ADT) is the standard of care. […] Patients with metastatic renal cancer may consider vascular endothelial growth factor targeted therapy over immunotherapy. […] Risks for delay in the treatment of upper tract urothelial cancer depend on grade and stage. […] Expert guidance recommends expedient local treatment of testis cancer. […] The coronavirus disease 2019 pandemic has led to delays in the treatment of patients with urologic malignancies. […] Based on a review of the literature, patients with high-grade urothelial carcinoma, advanced kidney cancer, testicular cancer, and penile cancer should be prioritized for treatment during these challenging times. 2020-05-19
32414757 First, it is a firm principle of medical ethics that an effective treatment or vaccine should not be withheld from patients if their life may depend on it. 2020-05-28
32414996 The long incubation period, high infectious rate, varied manifestation, and absence of effective treatment make it difficult to manage the disease transmission. […] Every patient presenting for treatment should be treated as a potential asymptomatic infected case. […] Patients should be categorized based upon the priority as acute (require immediate treatment/surgery within 24 h), sub-acute (requiring treatment within a maximum of 7-10 days), or chronic (requiring treatment within a month). 2020-05-20
32415305 Consequently, specific adjustments for their treatment need to be made to cope with this situation. […] Therefore, it is of significance to summarize the relevant experience of China in the prevention and control of COVID-19 infection and treatment of patients with cancer during the epidemic. 2020-05-29
32415348 Senior otologic surgeons from six teaching hospitals from various countries affected by the COVID-19 from around the world met remotely to make recommendations on reorganizing schedules for the treatment of cholesteatoma which has a risk of severe morbidity and mortality. 2020-05-19
32415419 Hydroxychloroquine (HCQ) is an old medication for malaria. 2020-05-19
32415426 Growing concerns about anxiety associated with COVID-19 have led to recommendations for effective self-care, and greater availability of mental health treatment. 2020-05-19
32415472 To evaluate stereotactic body radiotherapy (SBRT) in low-risk Prostate Cancer patients as preferred treatment option in emergency health conditions. 2020-05-19
32415494 In view of the inconsistent and limited evidence and after weighing up the benefits and risks, we would not currently recommend discontinuing or switching an effective treatment with RAS blockers. 2020-05-19
32415658 The treatment of patients with rectal cancer requires both a multidisciplinary approach and a significant amount of resources. […] It is therefore imperative to rethink how rectal cancer treatment can be aligned with the current COVID-19 pandemic paradigms. 2020-05-19
32415690 Resurgence in the use of chloroquine as a putative treatment for COVID-19 has seen recent cases of fatal toxicity due to unintentional overdoses. 2020-05-16
32415723 This statement also provides recommendations where appropriate in assessing indications for therapy, reducing therapy-associated immunosuppression and reducing healthcare utilisation in patients with specific haematological malignancies during the COVID-19 pandemic. […] Specific decisions regarding therapy of haematological malignancies will need to be individualised, based on disease risk, risks of immunosuppression, rates of community transmission of COVID-19 and available local healthcare resources. 2020-05-16
32415727 We aimed to assess health literacy, disease knowledge, treatment dissatisfaction and biologics attitudes toward COVID-19. […] Despite only 8.1% thought that biologics may increase the risk of COVID-19, 18.4% and 21.4% of the patients were evaluating the possibility to discontinue or modify the dosage of the current biologic therapy, respectively. […] Patients with lower DLQI (P = .006), longer disease duration (P = .051) and lower scholarity (P = .007) have thought to discontinue/modify autonomously their biologic therapy. 2020-05-28
32415767 In this expert opinion, conceived by the task force involving the Working Groups on Valvular Heart Diseases and Cardiac Surgery as well as the Association of Cardiovascular Intervention of the Polish Cardiac Society, modification of diagnostic pathways, principles of healthcare personnel protection, and treatment guidelines regarding triage and prioritization are suggested. […] Heart Teams responsible for the treatment of valvular heart disease should continue their work using telemedicine and digital technology. […] The treatment of aortic stenosis and mitral regurgitation has to be offered particularly due to urgent indications and in patients with advanced disease and poor prognosis. […] Importantly, as soon as the local epidemic situation improves, efforts must be made to restore standard opportunities for elective treatment of valvular heart disease and occluder‑based therapies according to existing guidelines, thus rebuilding the state ‑of ‑the ‑art cardiovascular services. 2020-05-29
32415882 We provide recommendations for preoperative tests, indications for immediate care vs possible delayed treatment, and warnings relating to dural resection and intracranial dissection, given the potential neurotropism of SARS-CoV2 and practical suggestions for managing cancer care in a period of limited resources. […] We also postulate some thoughts on the promising role of telemedicine in multidisciplinary case discussions and posttreatment surveillance. 2020-05-16
32415905 Both cases were discharged following a treatment regimen including discontinued immunosuppressant and low-dose methylprednisolone-based therapy. […] There were no signs of rejection during the treatment. 2020-05-16
32416116 Of these, 14.3% required renal replacement therapy (RRT). 2020-05-30
32416121 Their demographic data, medical history, signs and symptoms of COVID-19, laboratory test results, and final outcomes of COVID-19 treatment were collected and analyzed. 2020-05-31
32416259 A promising target for both diagnosis and therapeutics treatments of the new disease named COVID-19 is the coronavirus (CoV) spike (S) glycoprotein. 2020-05-31
32416289 We included patients hospitalized at the University Hospital of Rome Tor Vergata, medical center dedicated to the treatment of patients with COVID-19 diagnosis, who underwent an anamnestic interview about sNS consisting of 13 items, each related to a specific symptom, requiring a dichotomized answer. 2020-05-22
32416330 Treatment decisions in patients with multiple sclerosis (MS) during the coronavirus disease 2019 (COVID-19) pandemic are challenging. […] Case report RESULTS: We report a fingolimod-treated MS patient who developed severe COVID-19 but recovered after treatment with tocilizumab. […] This report suggests that a brief course of tocilizumab for the treatment of severe COVID-19 may be effective while not aggravating pre-existing MS. 2020-05-26
32416370 Similar ‘symptoms alert-to-admission’ and ‘door-to-treatment’ times were observed. 2020-05-29
32416415 Mortality is principally due to severe Acute Respiratory Distress Syndrome (ARDS) which relays only on supportive treatment. […] These observations prompt to consider this cytotoxic therapy in HLH associated to moderately severe to severe forms of COVID-19. 2020-05-26
32416527 SMBG needs to be practiced on regular basis, especially among the patients with diabetes on insulin therapy. 2020-05-27
32416535 This proposed model is premised on transmission of SARS-CoV-2 from human feces through municipal waste water treatment plants into the natural aquatic environment where potential wildlife hosts become infected. 2020-05-29
32416769 Kidney involvement is frequent, with clinical presentation ranging from mild proteinuria to progressive acute kidney injury (AKI) necessitating renal replacement therapy (RRT). […] As no specific treatment options exist for AKI secondary to COVID-19, intensive care is largely supportive. 2020-05-29
32416785 RAAS inhibitors do not increase the risk of COVID-19 requiring admission to hospital, including fatal cases and those admitted to intensive care units, and should not be discontinued to prevent a severe case of COVID-19. 2020-05-31
32417070 Availability of personal protective equipment (PPE) and medication was better than alcohol (70% conc.). […] Government and policymakers strive to mitigate the shortage of PPE and medication. 2020-05-20
32417123 This targeted strategy consists of using fully recovered COVID 19 Heroes, that is, brave volunteers, as the source of antibodies in plasma collected by plasmapheresis or affinity column- derived antibodies, both are sterilised and pathogen inactivated for substitution therapy for use in those populations in need of antibody. 2020-05-19
32417136 A patient with severe CRSwNP, asthma, and NSAIDS received dupilumab treatment. […] Three weeks after therapy onset, the patient was diagnosed with Covid-19, had a mild course of the disease, and fully recovered from the infection. 2020-05-30
32417164 The treatment of sleep disorders has been strongly impacted by the COVID-19 pandemic. […] In this document, the French Association of Otorhinolaryngology and Sleep disorders (AFSORL) and the French Society of Otorhinolaryngology (SFORL) put forward a summary of the measures for continuing the treatment of sleep apnoea syndrome in these new practice conditions. […] Emphasis is placed on teleconsultation, methods of nocturnal sleep studies, the conditions for treatment by continuous positive airway pressure (CPAP) ventilation, and the postponement of more invasive treatments. 2020-05-20
32417210 Compared with patients in discharged group, the patients in un-discharged/died group suffered from decreased counts of total T lymphocytes, CD4 + T lymphocytes, CD8 + T lymphocytes, as well as NK cells at 2 weeks after treatment. […] Lymphopenia and eosinopenia may serve as predictors of disease severity and disease progression in COVID-19 patients, and enhancing the cellular immunity may contribute to COVID-19 treatment. […] Thus, PBICs might become a sentinel of COVID-19, and it deserves attention during COVID-19 treatment. 2020-05-31
32417380 Demographic, clinical, laboratory, radiologic, treatment, and mortality data were collected and analyzed. 2020-05-26
32417555 This will allow to reveal true scale of Covid-19 outbreak associated with population link to a specific wastewater treatment plant. 2020-05-28
32417708 The role of hydroxychloroquine (HCQ) in the treatment of COVID-19 is not fully known. 2020-05-27
32417709 This is a narrative mini-review with Pubmed search until April 23, 2020 using the keywords COVID-19, SARS-CoV-2, treatment of coronavirus and following terms: diabetes mellitus, obesity, arterial hypertension, ACE-inhibitors, cytokine storm, immune response and vitamin D. […] Currently, since there is no proven and effective antiviral therapy for SARS-CoV-2, the efforts should focus on controlling inflammatory response and reduce the risks of associated complications. 2020-05-27
32417870 Treatment of the infected requires decisions in resource constraint situation particularly ICU beds and ventilators. 2020-05-21
32418028 These observations warrant further well-designed studies, yet we believe it is time for a global consideration of sampling all asymptomatic patients before surgical treatment. 2020-05-20
32418114 All 550 patients received comparable basic treatments including antiviral drugs and antibiotics, and 48 of them were treated with oral HCQ treatment (200 mg twice a day for 7-10 days) in addition to the basic treatments. […] The levels of inflammatory cytokine IL-6 were significantly reduced from 22.2 (8.3-118.9) pg mL-1 at the beginning of the treatment to 5.2 (3.0-23.4) pg mL-1 (P<0.05) at the end of the treatment in the HCQ group but there is no change in the NHCQ group. […] Therefore, HCQ should be prescribed as a part of treatment for critically ill COVID-19 patients, with possible outcome of saving lives. hydroxychloroquine, IL-6, mortalities, COVID-19. 2020-05-20
32418146 Main themes encompassed testing strategies and results (n = 4), changes in use of current therapeutics (n = 3), preventive measurements of transmission and management of COVID-19 (n = 3), and changes in standard clinical care (n = 3). 2020-05-20
32418181 COVID-19 infection has shown rapid growth worldwide, and different therapies have been proposed for treatment, in particular, the combination of immune response modulating drugs such as chloroquine and hydroxychloroquine (antimalarials) alone or in combination with azithromycin. 2020-05-20
32418190 At present, there is no definitive antiviral treatment for coronavirus disease 2019 (COVID-19). […] Nasal swab SARS-CoV-2 RNA became negative in three of four patients after 3 days of therapy. 2020-05-20
32418199 Many factors have been associated with both altered ACE2 expression and COVID-19 severity and progression, including age, sex, ethnicity, medication and several co-morbidities, such as cardiovascular disease and metabolic syndrome. […] Identifying pathologic changes caused by SARS-CoV-2 infection is crucially important as it has major implications for understanding COVID-19 pathophysiology and the development of evidence-based treatment strategies. […] Finally, we highlight a selection of potential treatment modalities for COVID-19. 2020-05-21
32418288 A progressive clinical improvement along with a reduction of CSF parameters was observed after high-dose steroid treatment, thus arguing for an inflammatory-mediated brain involvement related to Covid-19. 2020-05-17
32418377 However, attention should be paid to acute kidney injury of the elderly patients in the diagnosis and treatment of COVID-19. 目的: 分析新型冠状病毒肺炎(COVID-19)与肾损伤的关系。 2020-05-17
32418446 We report a series of febrile pediatric patients with acute heart failure potentially associated with SARS-CoV-2 infection and the multisystem inflammatory syndrome in children (MIS-C) as defined by the US Centers for Disease Control. Methods: Over a two-month period contemporary with the SARS-CoV-2 pandemic in France and Switzerland, we retrospectively collected clinical, biological, therapeutic, and early outcomes data in children who were admitted to pediatric intensive care units in 14 centers for cardiogenic shock, left ventricular dysfunction and severe inflammatory state. Results: Thirty-five children were identified and included in the study. […] All patients received intravenous immune globulin, with adjunctive steroid therapy used in one third. […] Treatment with immune globulin appears to be associated with recovery of left ventricular systolic function. 2020-05-18
32418460 Due to its highly contagious nature and unprecedented global spread, its aggressive clinical presentation and the lack of effective treatment, SARS-CoV-2 infection is causing the losses of thousands of lives and imparting unparalleled strains on healthcare systems around the world. 2020-05-18
32418463 Medicine and public health have traditionally separated the prevention and treatment of communicable and non-communicable diseases. 2020-05-18
32418532 The track for a possible COVID-19 treatment would be to target RAS using specific candidate chemotherapeutic drugs. 2020-05-18
32418728 Non-steroidal anti-inflammatory drugs (NSAIDs) have an optional prescription status that has resulted in frequent use, in particular for the symptomatic treatment of fever and non-rheumatic pain. […] First, the clinical observations of the French Pharmacovigilance Network showed that severe bacterial infections can occur even after a short NSAID treatment, and even if the NSAID is associated with an antibiotic. […] Therefore, in case of infection, symptomatic treatment with NSAIDs for non-severe symptoms (fever, pain, or myalgia) is not to be recommended, given a range of clinical and scientific arguments supporting an increased risk of severe bacterial complication. 2020-05-20
32418773 A proposal to adapt treatment strategies was made for the main GI oncology situations. […] Healthcare teams need to consider adapting treatment sequences when feasible and according to the epidemic situation. 2020-05-29
32418885 Currently, no specific prophylactic and therapeutic treatment is available. […] No evidence from randomized clinical trials (RCTs) that a treatment may ameliorate the clinical outcome of patients with COVID-19 exists with the only exception of preliminary evidence from remdesivir trials. […] Here, we present evidence from the literature and a compelling hypothesis on the potential immunomodulatory, iron chelating and anti-oxidant effects of iron chelators in the treatment of COVID-19 and its complications. […] Both retrospective analyses of data in electronic health records, as well as proof of concept studies in humans and large RCTs are needed to fully elucidate the efficacy and safety of iron chelating agents in the therapeutic armamentarium of COVID-19, probably as an adjunctive treatment. 2020-05-28
32418894 Recent global outbreak of the pandemic caused by coronavirus (COVID-19) emphasizes the urgent need for novel antiviral therapeutics. […] The review elaborates the mechanism of action, safety (side effects, adverse effects, toxicity) and details of clinical trials for chloroquine and hydroxychloroquine to benefit the clinicians, medicinal chemist, pharmacologist actively involved in controlling the pandemic and to provide therapeutics for the treatment of COVID-19 infection. 2020-05-29
32418917 Presently, few treatment options exist and the availability of effective vaccines is at least one year away. […] There is an urgent need to find currently available, effective therapies in the treatment of patients with COVID-19 infection. […] In this review, we compare and contrast the use of intravenous immunoglobulin and hyperimmune globulin in the treatment of COVID-19 infection. 2020-05-29
32419272 In Taiwan, a COVID-19 Open Science Platform adheres to the spirit of open science: sharing sources, data, and methods to promote progress in academic research while corroborating findings from various disciplines has established in mid-February 2020, for collaborative research in support of the development of detection methods, therapeutics, and a vaccine for COVID-19. […] Research priorities include infection control, epidemiology, clinical characterization and management, detection methods (including viral RNA detection, viral antigen detection, and serum antibody detection), therapeutics (neutralizing antibody and small molecule drugs), vaccines, and SARS-CoV-2 pathogenesis. 2020-05-18
32419401 In future outbreaks of emerging infectious diseases, efforts should be focused toward the provision of continued ED treatment with the implementation of revised triage and surveillance protocols. 2020-05-19
32419524 However, apart from supportive care by respirators, no standard medical therapy is validated.Areas covered: This paper presents old drugs with potential in vitro efficacy against SARS-CoV-2. […] The in vitro database, adverse effects, and potential toxicities of these drugs are reviewed regarding their feasibility of clinical prescription for the treatment of patients with COVID-19. […] To obtain convincing recommendations, we referred to opinions from the US National Institute of Health regarding drugs repurposed for COVID-19 therapy.Expert opinion: Although strong evidence of well-designed randomized controlled studies regarding COVID-19 therapy is presently lacking, remdesivir, teicoplanin, hydroxychloroquine (not in combination with azithromycin), and ivermectin might be effective antiviral drugs and are deemed promising candidates for controlling SARS-CoV-2. […] In addition, tocilizumab might be considered as the supplementary treatment for COVID-19 patients with cytokine release syndrome. […] In future, clinical trials regarding a combination of potentially effective drugs against SARS-CoV-2 need to be conducted to establish the optimal regimen for the treatment of patients with moderate-to-severe COVID-19. 2020-05-18
32419544 Since there is no approved treatment or drug for this disease, prevention of infection and breaking the chain of transmission plays a crucial role. 2020-05-18
32419705 COVID-19 pandemic caused not only many deaths around the world but also made evident technical limitations of hospital and intensive care units (ICU). 2020-05-18
32419715 The Spanish Working Group on Crohn’s Disease and Ulcerative Colitis (GETECCU) and the Spanish Nurses Working Group on Inflammatory Bowel Disease (GETEII) have prepared this document as a practical response to some common questions about the treatment of these patients. 2020-05-18
32419749 Timely treatment of acute stroke is critical to prevent disability. 2020-05-22
32419750 Additionally, lockdown and social distancing may pose hurdles in the provision of optimum medical therapy, particularly if patients experience motor and non-motor deteriorations due to diverse reasons. 2020-05-22
32419752 Hence physicians should be made aware of the new rules of the game in treating migraines during this time of the pandemic so that these patients get optimum treatment and care and don’t feel left out. 2020-05-22
32419767 Thus, timely treatment of diabetic foot ulcers is extremely important. […] However, timely patient treatment during the COVID-19 pandemic is particularly challenging, because of the higher volume of patients and the need to ensure safety of medical personnel. […] This article describes a proposed strategy for diagnosis and treatment of diabetic foot ulcers, based on experiences with infection and control strategies during the COVID-19 pandemic in China. 2020-05-18
32419838 A knowledge-based analysis strongly suggests a possible repositioning of the anti-HCV direct antiviral agent (DAA) Sofosbuvir as treatment for SARS-CoV-2. 2020-05-22
32419840 Another main threat is an increased risk for parental mental illness, domestic violence and child maltreatment. […] To maintain regular and emergency child and adolescent psychiatric treatment during the pandemic is a major challenge but is necessary for limiting long-term consequences for the mental health of children and adolescents. […] Urgent research questions comprise understanding the mental health effects of social distancing and economic pressure, identifying risk and resilience factors, and preventing long-term consequences, including-but not restricted to-child maltreatment. 2020-05-22
32419926 Actin protein was also suggested as a host factor that participates in cell entry and pathogenesis of SARS-CoV-2; therefore, drugs modulating biological activity of this protein (e.g. ibuprofen) were suggested as potential candidates for treatment of this viral infection. 2020-05-26
32419998 The goal of this work is to use our experience at a large, academic medical center as a lens for interpreting the many looming issues specific to radiosurgery and its role in the treatment of brain and spine disorders. 2020-05-22
32420049 Mesenchymal stem cell therapy offers a promising approach towards mitigating the delirious effects of the infection in the COVID-19 patients. […] This therapy has shown to reduce the expression of pro-inflammatory cytokines as well as repair of damaged tissues in COVID-19 patients. […] This review has been organized to put forward the positive aruments and implications in support of mesenchymal stem cell therapy as a necessary approach for treating COVID-19 patients. 2020-05-22
32420073 At last, more attention to the protection of cancer patients and give priority to the treatment of infected cancer patients. 2020-05-22
32420305 Following treatment with early non-invasive ventilation and a bundle pharmacotherapy, she recovered with a good outcome. […] Early non-invasive ventilation with a bundle pharmacotherapy may be an effective treatment regimen for the broader population of patients with COVID-19. 2020-05-22
32420607 The severity of COVID-19 disease has a wide range and varies from asymptomatic to critical severe, clinical researches reported that 10-15% of the patients were in the severe situation and required a great deal of attention of treatment and nursing (WHO-China-Joint-Mission 2020). 2020-05-18
  1. Patients with haematological malignancies are expected to be at increased risk of adverse outcomes from this viral infection, due being immunosuppressed as a consequence of the underlying cancer, and from the effects of therapy.
32420631 The application of evidence-based approaches to the identification and management of treatment and tumor-related toxicities has embraced the use of validated patient-reported outcomes instruments, health promotion, and care coordination. […] In this manuscript, we describe how our multidisciplinary team of survivorship providers has accommodated to the need to provide patients with social distancing while acknowledging the importance of continued care during treatment and through the spectrum of survivorship. 2020-05-18
32420637 Over thousand clinical trials with COVID-19 patients are already listed in, some of them for assessing the utility of therapeutics approved for other conditions. […] A much faster and by far more efficient method for rapidly identifying approved therapeutics that can be repurposed for treating COVID-19 patients is data mining their past and current electronic health and prescription records for identifying drugs that may protect infected individuals from severe COVID-19 symptoms. 2020-05-19
32420691 Over the last several decades, as technology has developed to purify and manufacture plasma-derived immunoglobulin (IG) as a drug therapy, hyperimmune globulin (H-IG) formulations have been used as the second line of passive immunotherapies against these diseases. 2020-05-18
32420705 However, there is no one-size-fits-all approach for monitoring, treatment and referral decisions. 2020-05-20
32420710 We retrospectively assessed 169 consecutive patients with laboratory‑ confirmed COVID‑ 19 with regard to their clinical manifestations, radiological findings, treatment, complications, and outcomes. 2020-05-29
32420751 Since the outbreak of Corona Virus Disease 2019 (COVID-19) in Hubei province, the epidemic scale has increased rapidly, and no effective antiviral drug therapy has been identified yet. […] This study aimed to evaluate the adjuvant efficacy of Natural Herbal Medicine (NHM) combined with Western medicine in the treatment of COVID-19. […] A total of 22 of the 36 confirmed patients were included in this study, split into two groups of 11: the NHM group (NHM combined standard Western medicine treatment) and control group (standard Western medicine treatment alone). […] Our results suggest that NHM could improve the clinical symptoms of COVID-19 patients and may be effective in treating COVID-19; thus, a larger, prospective, randomized, controlled clinical trial should be conducted to further evaluate the adjuvant efficacy of NHM in the treatment of COVID-19. 2020-05-18
32420777 Introduction: With the emergence of novel coronavirus disease 2019 (COVID-19) in many countries, medical resources currently focus on the treatment of confirmed patients and screening of suspected cases. […] She was given antiviral and symptomatic supportive treatment. 2020-05-18
32420788 With the spread of the novel coronavirus, the outpatient lines of hospitals have mostly shut down, which means that routine clinical diagnosis and treatment for autoimmune bullous diseases patients have been disturbed. […] Clinicians should strengthen their communication with patients, pay attention to changes in patients’ conditions, and carefully adjust the treatment strategy, while protecting against the novel coronavirus infection, to ensure the continuity, safety, and effectiveness of autoimmune bullous diseases treatment. 2020-05-18
32420913 We offer to the forensic odontologists’ community a short summary of some old and new hints on the treatment of dead bodies in the autopsy room during this pandemic emergency time. 2020-05-20
32420927 From the preliminary data of this study, it appears that the Bari Polyclinic has adopted the same therapeutic strategies started in China in the previous months, believing early diagnosis and treatment to be a strength in the battle against COVID-19. 2020-05-26
32420936 Along with extensive public health measures, an unprecedented global effort in identifying effective drugs for the treatment is being implemented. 2020-05-26
32420939 This narrative review starts from diagnostic evaluation, continues with adapted pharmacologic treatment and ends with the recovery phase targeting the nutrition and physical exercise. […] We finally considered timing and selection of treatment, which depend on the disease phase, co-administration of other drugs and require the monitoring of renal, liver and cardiac function. 2020-05-26
32420944 MicroRNAs (miRNA9) systems are potent post-transcriptional gene expression regulators that are important modulators of viral infections, and could play an important role in the treatment of viral infections. 2020-05-22
32420958 Sofosbuvir may be a potential option in the treatment of COVID-19 based on the similarity between the replication mechanisms of the HCV and the coronavirus. […] Efficacy and safety of sofosbuvir in treatment of COVID-19 may be considered in future clinical studies. 2020-05-22
32421258 Information on demographic characteristics, exposure history, ocular symptoms, eye drop medication, eye protections, chronic eye diseases, systemic concomitant symptoms, radiologic findings and SARS-CoV-2 detection in nasopharyngeal swabs by real-time PCR was collected from questionnaires and electronic medical records. 2020-05-18
32421292 The race to minimize the damage caused by COVID-19 requires that we obtain knowledge about the disease and its treatment or prevention, how to best safeguard public health and avoid overwhelming the health care system, and how to minimize the societal damage caused by substantial disruption of the economy. 2020-05-29
32421381 Background: To investigate deep vein thrombosis (DVT) in hospitalized patients with coronavirus disease 2019 (COVID-19), we performed a single institutional study to evaluate its prevalence, risk factors, prognosis, and potential thromboprophylaxis strategies in a large referral and treatment center. Methods: We studied a total of 143 patients with COVID-19 from January 29 to February 29, 2020. 2020-05-18
32421539 Chest CT has a higher sensitivity and can play an essential role in the diagnosis and treatment of the disease. 2020-05-22
32421541 Although aerosol therapy is a mainstay procedure used to treat pulmonary diseases at home and healthcare settings, it has a potential for fugitive emissions during therapy due to the generation of aerosols and droplets as a source of respiratory pathogens. […] This has been a real concern for caregivers and healthcare professionals who are susceptible to unintended inhalation of fugitive emissions during therapy. […] Due to a scarcity of information in this area of clinical practice, the purpose of this paper is to explain how to deliver aerosolized medications to mild-, sub-intensive, and intensive-care patients with COVID-19 and how to protect staff from exposure to exhaled droplets during aerosol therapy. 2020-05-22
32421627 As a matter of fact, testing accelerates life-saving decisions on treatment and isolation of COVID-19 patients in an early stage, and thereby, decelerating or even preventing the spread of such emerging infectious diseases. 2020-05-29
32422062 The role of angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin-receptor blockers (ARBs) in COVID-19 disease susceptibility, severity, and treatment is unclear. […] To evaluate, on an ongoing basis, whether use of ACEIs or ARBs either increases risk for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection or is associated with worse COVID-19 disease outcomes, and to assess the efficacy of these medications for COVID-19 treatment. […] Fourteen observational studies, involving a total of 23 565 adults with COVID-19, showed consistent evidence that neither medication was associated with more severe COVID-19 illness (high-certainty evidence). […] Four registered randomized trials plan to evaluate ACEIs and ARBs for treatment of COVID-19. […] Whether these medications increase the risk for mild or asymptomatic disease or are beneficial in COVID-19 treatment remains uncertain. 2020-05-20
32422076 Ten of the 11 patients received prophylactic anticoagulant therapy; venous thromboembolism was not clinically suspected antemortem in any of the patients. […] Studies are needed to further understand the thrombotic complications of COVID-19, together with the roles for strict thrombosis prophylaxis, laboratory, and imaging studies and early anticoagulant therapy for suspected pulmonary arterial thrombosis or thromboembolism. 2020-05-20
32422146 We determined effects of IL-13 treatment on ACE2 and TMPRSS2 expression ex vivo in primary airway epithelial cells from participants with and without type 2 asthma obtained by bronchoscopy. 2020-05-20
32422178 However, the role of antifibrotic therapy in patients with IPF who contract SARS-CoV-2 infection, and the scientific rationale for their continuation or cessation, is poorly defined. 2020-05-22
32422287 We herein report a rare case of the ruptured popliteal artery aneurysm in an 89-year-old man, whose recovery after surgical treatment was complicated with acute respiratory distress syndrome secondary to confirmed infection with SARS-CoV-2. 2020-05-30
32422288 Endovascular treatment and early anticoagulation are the key for success for vascular emergencies in COVID-19 patients, despite the risk of late endoleak. 2020-05-22
32422305 Until now, there is not a specific and definitive treatment for this pathology that worries the world population, especially the older adults who constitute the main risk group. 2020-05-29
32422331 In a few hospitals, existing neurosurgical and medical intensive care units have been converted to isolation intensive care units. 2020-05-29
32422349 Further clinical trials are required to ascertain the need for early therapeutic anticoagulation or fibrinolytic therapy to address this state of fibrinolysis shutdown. 2020-05-22
32422364 A major consideration in the delivery of cancer care during the pandemic is to balance the risk of patient exposure and infection with the need to provide effective cancer treatment. […] Infection at any level for patients or providers can cause considerable disruption to even the most effective treatment plans. […] The purpose of this manuscript is to present a practical multidisciplinary and international overview to assist in treatment for lung cancer patients during this pandemic, with the caveat that evidence is lacking in many areas. 2020-05-31
32422376 We report the first successful treatment with the IL-1 receptor antagonist anakinra, in association with the most promising and available antiviral therapy, of a severe case of novel coronavirus disease 2019 (COVID-19). […] We describe the diagnosis, clinical course, and management of the case, including the respiratory failure at presentation, the progression to a scenario characterized by profound inflammatory dysregulation similar to that observed during macrophage activation syndrome, and the clinical improvement after treatment with the IL-1 receptor antagonist anakinra. […] This case highlights the high tolerability and the interesting immunomodulatory profile of the IL-1 receptor antagonist anakinra in the setting of severe COVID-19 associated with remdesivir therapy. […] Further studies are needed to confirm the safety and efficacy of this combination strategy in the treatment of this emerging infection. 2020-05-20
32422384 Furthermore, we present an overview of diagnostic approaches and treatment of this disease according to available findings. 2020-05-22
32422426 Psychiatrists, neurologists and physicians in general should be aware of this symptom presentation in order to avoid mistreatment, given that persistent olfactory dysfunction might increase the risks of nutritional deficit and lead to development of adjustment disorders. 2020-05-26
32422645 These results pave the way for using S309- and S309-containing antibody cocktails for prophylaxis in individuals at high risk of exposure or as a post-exposure therapy to limit or treat severe disease. 2020-05-18
32422662 Especially, in preparation for expected mass casualty inc