Treatment Sentence Context


Table 1. Analysis of context sentence of 3839 absracts clustered as Treatment

Title Gene Context Sentence ePubDate
Recent advances in the detection of respiratory virus infection in humans. Identification of the causative viral pathogens of respiratory tract viral infections is important to select an appropriate treatment, save people’s lives, stop the epidemics, and avoid unnecessary use of antibiotics. 2020-03-19
Coronavirus infections and immune responses. In this review, we provide an update on CoV infections and relevant diseases, particularly the host defense against CoV-induced inflammation of lung tissue, as well as the role of the innate immune system in the pathogenesis and clinical treatment. 2020-03-19
Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. We report the epidemiological, clinical, laboratory, and radiological characteristics and treatment and clinical outcomes of these patients. 2020-03-13
Drug treatment options for the 2019-new coronavirus (2019-nCoV). At present, there is no vaccine or antiviral treatment for human and animal coronavirus, so that identifying the drug treatment options as soon as possible is critical for the response to the 2019-nCoV outbreak. […] Three general methods, which include existing broad-spectrum antiviral drugs using standard assays, screening of a chemical library containing many existing compounds or databases, and the redevelopment of new specific drugs based on the genome and biophysical understanding of individual coronaviruses, are used to discover the potential antiviral treatment of human pathogen coronavirus. […] Lopinavir /Ritonavir, Nucleoside analogues, Neuraminidase inhibitors, Remdesivir, peptide (EK1), abidol, RNA synthesis inhibitors (such as TDF, 3TC), anti-inflammatory drugs (such as hormones and other molecules), Chinese traditional medicine, such ShuFengJieDu Capsules and Lianhuaqingwen Capsule, could be the drug treatment options for 2019-nCoV. 2020-03-18
Measures for diagnosing and treating infections by a novel coronavirus responsible for a pneumonia outbreak originating in Wuhan, China. Here, we focus on advances in research and development of fast diagnosis methods, as well as potential prophylactics and therapeutics to prevent or treat 2019-nCoV infection. 2020-03-18
The Novel Coronavirus: A Bird’s Eye View. Herein, we present on an overview of the currently available information on the pathogenesis, epidemiology, clinical presentation, diagnosis, and treatment of this virus. 2020-04-13
Learning from the Past: Possible Urgent Prevention and Treatment Options for Severe Acute Respiratory Infections Caused by 2019-nCoV. The spike protein used for host cell infection shows key nonsynonymous mutations that might hamper the efficacy of previously developed therapeutics but remains a viable target for the development of biologics and macrocyclic peptides. 2020-03-18
[Diagnosis and clinical management of 2019 novel coronavirus infection: an operational recommendation of Peking Union Medical College Hospital (V2.0)]. To standardize the diagnosis and treatment of this new infectious disease, operational guidelines for the diagnosis and management of 2019-nCoV infection is accomplished by Peking Union Medical College Hospital. 2020-02-05
[2019-nCoV: new challenges from coronavirus]. The outbreak of pneumonia caused by the novel coronavirus 2019-nCoV in Wuhan, Hubei province of China, at the end of 2019 shaped tremendous challenges to China’s public health and clinical treatment. 2020-02-05
[Efficient management of novel coronavirus pneumonia by efficient prevention and control in scientific manner]. Based on current studies, the author summarized the clinical characteristics and evolution of the novel viral pneumonia, and proposed the key points of diagnosis and treatment, the scientific management of both confirmed and suspected cases, and the scientific management of disease prevention and control. 2020-02-05
Diagnosis and treatment recommendations for pediatric respiratory infection caused by the 2019 novel coronavirus. Following the latest National recommendations for diagnosis and treatment of pneumonia caused by 2019-nCoV (the 4th edition) and current status of clinical practice in Zhejiang Province, recommendations for the diagnosis and treatment of respiratory infection caused by 2019-nCoV for children were drafted by the National Clinical Research Center for Child Health, the National Children’s Regional Medical Center, Children’s Hospital, Zhejiang University School of Medicine to further standardize the protocol for diagnosis and treatment of respiratory infection in children caused by 2019-nCoV. 2020-02-06
Initial Public Health Response and Interim Clinical Guidance for the 2019 Novel Coronavirus Outbreak - United States, December 31, 2019-February 4, 2020. Although these measures might not prevent the eventual establishment of ongoing, widespread transmission of the virus in the United States, they are being implemented to 1) slow the spread of illness; 2) provide time to better prepare health care systems and the general public to be ready if widespread transmission with substantial associated illness occurs; and 3) better characterize 2019-nCoV infection to guide public health recommendations and the development of medical countermeasures including diagnostics, therapeutics, and vaccines. 2020-02-07
A rapid advice guideline for the diagnosis and treatment of 2019 novel coronavirus (2019-nCoV) infected pneumonia (standard version). For it is a never been experienced respiratory disease before and with infection ability widely and quickly, it attracted the world’s attention but without treatment and control manual. […] This guideline includes the guideline methodology, epidemiological characteristics, disease screening and population prevention, diagnosis, treatment and control (including traditional Chinese Medicine), nosocomial infection prevention and control, and disease nursing of the 2019-nCoV. […] Moreover, we also provide a whole process of a successful treatment case of the severe 2019-nCoV infected pneumonia and experience and lessons of hospital rescue for 2019-nCoV infections. 2020-03-19
Clinical Characteristics of 138 Hospitalized Patients With 2019 Novel Coronavirus-Infected Pneumonia in Wuhan, China. Epidemiological, demographic, clinical, laboratory, radiological, and treatment data were collected and analyzed. […] Most patients received antiviral therapy (oseltamivir, 124 [89.9%]), and many received antibacterial therapy (moxifloxacin, 89 [64.4%]; ceftriaxone, 34 [24.6%]; azithromycin, 25 [18.1%]) and glucocorticoid therapy (62 [44.9%]). […] Of the 36 cases in the ICU, 4 (11.1%) received high-flow oxygen therapy, 15 (41.7%) received noninvasive ventilation, and 17 (47.2%) received invasive ventilation (4 were switched to extracorporeal membrane oxygenation). 2020-03-13
[Interpretation of “Guidelines for the Diagnosis and Treatment of Novel Coronavirus (2019-nCoV) Infection by the National Health Commission (Trial Version 5)”]. the National Health Commission of the People’s Republic of China publish the guidelines for the diagnosis and treatment of novel coronavirus (2019-nCoV) infection (trial version 5) . 2020-02-08
Diagnosis, treatment, and prevention of 2019 novel coronavirus infection in children: experts’ consensus statement. This statement is based on the Novel Coronavirus Infection Pneumonia Diagnosis and Treatment Standards (the fourth edition) (National Health Committee) and other previous diagnosis and treatment strategies for pediatric virus infections. […] The present consensus statement summarizes current strategies on diagnosis, treatment, and prevention of 2019-nCoV infection in children. 2020-02-08
[Suggestions for disinfection of ophthalmic examination equipment and protection of ophthalmologist against 2019 novel coronavirus infection]. At present, the prevention and treatment of 2019 Novel Coronavirus (2019-nCoV) in China has reached a critical stage. 2020-02-08
Clinical characteristics and therapeutic procedure for four cases with 2019 novel coronavirus pneumonia receiving combined Chinese and Western medicine treatment. No effective antiviral treatment has been verified thus far. […] All the patients were given antiviral treatment including lopinavir/ritonavir (Kaletra®), arbidol, and Shufeng Jiedu Capsule (SFJDC, a traditional Chinese medicine) and other necessary support care. […] After treatment, three patients gained significant improvement in pneumonia associated symptoms, two of whom were confirmed 2019-nCoV negative and discharged, and one of whom was virus negative at the first test. […] Results obtained in the current study may provide clues for treatment of 2019-nCoV pneumonia. […] The efficacy of antiviral treatment including lopinavir/ritonavir, arbidol, and SFJDC warrants further verification in future study. 2020-03-18
Critical care management of adults with community-acquired severe respiratory viral infection. Oseltamivir is the most widely used neuraminidase inhibitor for treatment of influenza; data suggest that early use is associated with reduced mortality in critically ill patients with influenza. […] Limited existing knowledge highlights the need for data regarding supportive care and adjunctive pharmacologic therapy that is specific for critically ill patients with severe RVI. […] There is a need for more pragmatic and efficient designs to test different therapeutics both individually and in combination. 2020-03-18
Clinical characteristics of novel coronavirus cases in tertiary hospitals in Hubei Province. This study aims to investigate its epidemiologic history, and analyze the clinical characteristics, treatment regimens, and prognosis of patients infected with 2019-nCoV during this outbreak. […] Clinical data from 137 2019-nCoV-infected patients admitted to the respiratory departments of the respiratory departments of nine tertiary hospitals in Hubei province from December 30, 2019 to January 24, 2020 were retrospectively collected, including general status, clinical manifestations, laboratory test results, imaging characteristics, and treatment regimens. […] Given the lack of effective drugs, treatment focused on symptomatic and respiratory support. […] Systemic corticosteroid treatment did not show significant benefits. 2020-03-02
Clinical and biochemical indexes from 2019-nCoV infected patients linked to viral loads and lung injury. Our results suggest a number of potential diagnosis biomarkers and angiotensin receptor blocker (ARB) drugs for potential repurposing treatment of 2019-nCoV infection. 2020-03-19
Overview of The 2019 Novel Coronavirus (2019-nCoV): The Pathogen of Severe Specific Contagious Pneumonia (SSCP). Currently, there is no definite treatment for SSCP although some drugs are under investigation. 2020-02-12
[Perinatal and neonatal management plan for prevention and control of 2019 novel coronavirus infection (1st Edition)]. The perinatal-neonatal departments should cooperate closely and take integrated approaches, and the neonatal intensive care unit should prepare the emergency plan for 2019-nCoV infection as far as possible, so as to ensure the optimal management and treatment of potential victims. 2020-02-19
[Emergency response plan for the neonatal intensive care unit during epidemic of 2019 novel coronavirus]. During the epidemic of 2019-nCoV, the emergency response plan for the NICU should be based on the actual situation, including diagnosis, isolation, and treatment, as well as available equipment and staffing, and take into account the psychosocial needs of the families and neonatal care staff. 2020-02-19
[Recommendation for the diagnosis and treatment of novel coronavirus infection in children in Hubei (Trial version 1)]. In order to further standardize and enhance the clinical management of 2019-nCoV infection in children, reduce the incidence, and decrease the number of severe cases, we have formulated this diagnosis and treatment recommendation according to the recent information at home and abroad. 2020-02-19
Potential interventions for novel coronavirus in China: A systematic review. In the absence of treatment for this virus, there is an urgent need to find alternative methods to control the spread of disease. […] Here, we have conducted an online search for all treatment options related to coronavirus infections as well as some RNA-virus infection and we have found that general treatments, coronavirus-specific treatments, and antiviral treatments should be useful in fighting COVID-19. 2020-03-18
Prophylactic and therapeutic remdesivir (GS-5734) treatment in the rhesus macaque model of MERS-CoV infection. Here, we tested the efficacy of prophylactic and therapeutic remdesivir treatment in a nonhuman primate model of MERS-CoV infection, the rhesus macaque. […] Prophylactic remdesivir treatment initiated 24 h prior to inoculation completely prevented MERS-CoV-induced clinical disease, strongly inhibited MERS-CoV replication in respiratory tissues, and prevented the formation of lung lesions. […] Therapeutic remdesivir treatment initiated 12 h postinoculation also provided a clear clinical benefit, with a reduction in clinical signs, reduced virus replication in the lungs, and decreased presence and severity of lung lesions. […] The data presented here support testing of the efficacy of remdesivir treatment in the context of a MERS clinical trial. 2020-04-01
[Pharmacotherapeutics for the New Coronavirus Pneumonia]. We here share the therapeutic experiences of NCP treatment with literature review. 2020-02-14
The First Disease X is Caused by a Highly Transmissible Acute Respiratory Syndrome Coronavirus. With high human-to-human transmission rate (R0), 2019-nCoV has quickly spread in China and other countries, resulting in 34,953 confirmed cases and 725 deaths as of 8 February 2020, thus calling for urgent development of therapeutics and prophylactics. 2020-02-15
[Inhibitors of RAS Might Be a Good Choice for the Therapy of COVID-19 Pneumonia]. At present, there is no definite and effective treatment for COVID-19. 2020-02-15
[Analysis of CT features of 15 Children with 2019 novel coronavirus infection]. After 3 to 5 days of treatment, 2019-nCoV nucleic acid in a second respiratory sample turned negative in 6 cases. 2020-02-16
[The network investigation on knowledge, attitude and practice about Novel coronavirus pneumonia of the residents in Anhui Province]. Residents have a high awareness rate of the main symptoms, transmission routes, using of masks, hand washing and treatment information of NCP, while a low awareness rate of the atypical symptoms. 2020-02-17
[Analysis of the first cluster of cases in a family of novel coronavirus pneumonia in Gansu Province]. Among the 7 patients, 1 case died of (B) aggravation, and the other patients’ condition was effectively controlled after active treatment. 2020-02-17
Potent binding of 2019 novel coronavirus spike protein by a SARS coronavirus-specific human monoclonal antibody. Currently, however, there is no specific antiviral treatment or vaccine. […] These results suggest that CR3022 may have the potential to be developed as candidate therapeutics, alone or in combination with other neutralizing antibodies, for the prevention and treatment of 2019-nCoV infections. 2020-03-16
Can Chinese Medicine Be Used for Prevention of Corona Virus Disease 2019 (COVID-19)? A Review of Historical Classics, Research Evidence and Current Prevention Programs. Historical records on prevention and treatment of infections in CM classics, clinical evidence of CM on the prevention of severe acute respiratory syndrome (SARS) and H1N1 influenza, and CM prevention programs issued by health authorities in China since the COVID-19 outbreak were retrieved from different databases and websites till 12 February, 2020. 2020-04-03
[Health protection guideline of mobile cabin hospitals during Novel Coronavirus Pneumonia (NPC) outbreak]. This guideline is applicable to the health protection requirements of large indoor stadiums which are reconstructed as treatment sites for the Novel Coronavirus Pneumonia (NPC) patients with mild symptoms during the outbreak. 2020-02-19
Breakthrough: Chloroquine phosphate has shown apparent efficacy in treatment of COVID-19 associated pneumonia in clinical studies. The coronavirus disease 2019 (COVID-19) virus is spreading rapidly, and scientists are endeavoring to discover drugs for its efficacious treatment in China. […] Chloroquine phosphate, an old drug for treatment of malaria, is shown to have apparent efficacy and acceptable safety against COVID-19 associated pneumonia in multicenter clinical trials conducted in China. […] The drug is recommended to be included in the next version of the Guidelines for the Prevention, Diagnosis, and Treatment of Pneumonia Caused by COVID-19 issued by the National Health Commission of the People’s Republic of China for treatment of COVID-19 infection in larger populations in the future. 2020-03-18
[Treatment strategy for gastrointestinal tumor under the outbreak of novel coronavirus pneumonia in China]. As surgeons specialized in the treatment of gastrointestinal tumors, we should always be aware of the prevention for NCP and incorporate this awareness into every detail of clinical practice. […] For malignant tumor, multidisciplinary therapy (MDT) is recommended and non-surgical anti-tumor therapy should be selected with higher priority. […] Neoadjuvant therapy is highly recommended for gastrointestinal cancer at advanced stages that meet the indications of NCCN guideline (gastric cancer T stage ≥ 2/rectal cancer T stage ≥ 3/unresectable colon cancer). […] However, emergency operation still must be performed for patients with acute uncontrolled bleeding, obstruction or after other alternative treatment measures fail. 2020-03-12
[Expert consensus on chloroquine phosphate for the treatment of novel coronavirus pneumonia]. Here we found that treating the patients diagnosed as novel coronavirus pneumonia with chloroquine might improve the success rate of treatment, shorten hospital stay and improve patient outcome. […] In order to guide and regulate the use of chloroquine in patients with novel coronavirus pneumonia, the multicenter collaboration group of Department of Science and Technology of Guangdong Province and Health Commission of Guangdong Province for chloroquine in the treatment of novel coronavirus pneumonia developed this expert consensus after extensive discussion. 2020-02-20
[Preliminary Recommendations for Lung Surgery during 2019 Novel Coronavirus Disease (COVID-19) Epidemic Period]. For patients with lung occupying lesions, the whole process of diagnosis and treatment can not be carried out as usual due to the epidemic. […] All thoracic surgeons in China should work together to develop the proper procedures for the diagnosis and treatment in this special situation, and continuously update the recommendations based on epidemic changes and further understanding of COVID-19. 2020-03-16
[Clinical Management of Lung Cancer Patients during the Outbreak of 2019 Novel Coronavirus Disease (COVID-19)]. With the spread of COVID-19, the routine clinical diagnosis and treatment for lung cancer patients has been disturbed. […] During the COVID-19 outbreak period, it should be carefully differentiated for fever and respiratory symptoms for lung cancer patients receiving anti-tumor treatment, in order to evaluate the risk of COVID-19. 2020-03-16
[Preliminary study of the relationship between novel coronavirus pneumonia and liver function damage: a multicenter study]. Clinical classification (mild, moderate, severe, and critical) was carried out according to the diagnosis and treatment program of novel coronavirus pneumonia (Trial Fifth Edition) issued by the National Health Commission. […] ALT, AST, ALB and TBil of the severe or critical subgroups were 60.25 (40.88 ~ 68.90) U/L, 37.00 (20.88 ~ 64.45) U/L, 35.75 (28.68 ~ 42.00) g/L, and 20.50 (11.28 ~ 25.00) mmol/L, respectively. Conclusion: The results of this multicenter retrospective study suggests that novel coronavirus pneumonia combined with liver damage is more likely to be caused by adverse drug reactions and systemic inflammation in severe patients receiving medical treatment. […] Therefore, liver function monitoring and evaluation should be strengthened during the treatment of such patients. 目的: 分析新型冠状病毒肺炎病例的临床特征,初步探讨不同临床分型与肝功能损伤的关系。 2020-02-20
[Expert consensus on preventing nosocomial transmission during respiratory care for critically ill patients infected by 2019 novel coronavirus pneumonia]. As such, we developed this consensus recommendations on all those high-risk treatments, based on the current evidence as well as the resource limitation in some areas, with the aim to reduce the nosocomial transmission and optimize the treatment for the COVID-19 pneumonia patients. […] Those recommendations include: (1) Standard prevention and protection, and patient isolation; (2) Patient wearing mask during HFNC treatment; (3) Using dual limb ventilator with filters placed at the ventilator outlets, or using heat-moisture exchanger (HME) instead of heated humidification in single limb ventilator with HME placed between exhalation port and mask; avoid using mask with exhalation port on the mask; (4) Placing filter between resuscitator and mask or artificial airway; (5) For spontaneous breathing patients, placing mask for patients during bronchoscopy examination; for patients receiving noninvasive ventilation, using the special mask with bronchoscopy port to perform bronchoscopy; (6) Using sedation and paralytics during intubation, cuff pressure should be maintained between 25-30 cmH(2)O; (7) In-line suction catheter is recommended and it can be used for one week; (8) Dual-limb heated wire circuits are recommended and only changed with visible soiled; (9. […] (11) Avoid unnecessary bronchial hygiene therapy; (12) For patients who need aerosol therapy, dry powder inhaler metered dose inhaler with spacer is recommended for spontaneous breathing patients; while vibrating mesh nebulizer is recommended for ventilated patients and additional filter is recommended to be placed at the expiratory port of ventilation during nebulization. 2020-02-20
2019 novel coronavirus of pneumonia in Wuhan, China: emerging attack and management strategies. According to the current status, blocking transmission, isolation, protection, and alternative medication are the urgent management strategies against 2019-nCoV. 2020-03-06
Incubation Period and Other Epidemiological Characteristics of 2019 Novel Coronavirus Infections with Right Truncation: A Statistical Analysis of Publicly Available Case Data. The mean time from illness onset to hospital admission (for treatment and/or isolation) was estimated at 3-4 days without truncation and at 5-9 days when right truncated. 2020-03-20
[Emergency management of prevention and control of novel coronavirus pneumonia in departments of stomatology]. Complying with overall requirements of the government and regulations on public health emergences, as well as the clinical features of diagnosis and treatment of dental illness, this paper refers to previous guidelines and studies on the infection prevention and control in dental diagnosis and treatment in China and foreign countries. 2020-02-21
[Thinking of treatment strategies for colorectal cancer patients in tumor hospitals under the background of coronavirus pneumonia]. By summarizing the research progress and guidelines in recent years in the fields of colorectal cancer disease screening, treatment strategies(including early colorectal cancer, locally advanced colorectal cancer, obstructive colorectal cancer, metastatic colorectal cancer and the treatment of patients after neoadjuvant therapy), the choice of medication and time limit for adjuvant therapy, the protective measures for patients undergoing emergency surgery, the re-examination of postoperative patients and the protection of medical staff, etc., authors improve treatment strategies in order to provide more choices for patients to obtain the best treatment under the severe epidemic situation of new coronavirus pneumonia. […] Meanwhile we hope that it can also provide more timely treatment modeling schemes for colleagues. 2020-02-22
[Standardized diagnosis and treatment of colorectal cancer during the outbreak of novel coronavirus pneumonia in Renji hospital]. Referring to the “Diagnosis and Treatment Scheme for NCP (Trial Version 4 and 5)” and combining the actual practice situation in our hospital with the “Summary of New Coronavirus Files of Shanghai Renji Hospital”, we summarize how to carry out the clinical practice of colorectal surgery under the situation of the prevention and control of the NCP epidemiology, meanwhile under such situation aiming the procedure of diagnose and treatment for emergency patients with colorectal tumor, we share the experiences of the diagnosis of colorectal tumor, the management of patients with colorectal cancer who are scheduled to be admitted for surgery, the protection of wards, the perioperative management. […] The main points are as follows: (1) Multidisciplinary team (MDT) must be run through the diagnosis and treatment of colorectal cancer. 2020-02-22
[Psychological intervention in oral patients in novel coronavirus pneumonia outbreak period]. The outbreak of the novel coronavirus has affected the normal diagnosis and treatment services in oral medical institutions across the country. […] Delay of non-emergency dental service will have a potential impact on the experience, cognition, treatment and rehabilitation of patients with oral diseases. […] At the same time, this paper analyzes the possible psychological stress symptoms of patients with different oral diseases, and puts forward suggestions for remote consultation and emergency treatment of dentists. 2020-02-22
The SARS, MERS and novel coronavirus (COVID-19) epidemics, the newest and biggest global health threats: what lessons have we learned? Utilizing the Centers for Disease Control and Prevention (CDC, USA) website, and a comprehensive review of PubMed literature, we obtained information regarding clinical signs and symptoms, treatment and diagnosis, transmission methods, protection methods and risk factors for Middle East Respiratory Syndrome (MERS), Severe Acute Respiratory Syndrome (SARS) and COVID-19. 2020-02-22
The epidemic of 2019-novel-coronavirus (2019-nCoV) pneumonia and insights for emerging infectious diseases in the future. Herein, we describe the epidemic and etiological characteristics of 2019-nCoV, discuss its essential biological features, including tropism and receptor usage, summarize approaches for disease prevention and treatment, and speculate on the transmission route of 2019-nCoV. 2020-03-18
[The keypoints in treatment of the critical novel coronavirus pneumonia patient]. We will share the treatment experience of severe NCP with the first-line treatment experience. […] In addition, there is up regulation of inflammatory factors in patients with severe NCP, but the effect of renal replacement therapy needs to be further confirmed by clinical research. 2020-02-23
Lessons learned from the 2019-nCoV epidemic on prevention of future infectious diseases. These measures were motivated by the need to provide effective treatment of patients, and involved consultation with three major groups in policy formulation-public health experts, the government, and the general public. 2020-03-18
COVID-19: Real-time dissemination of scientific information to fight a public health emergency of international concern. This issue has rapidly reviewed and published articles describing COVID-19, including the drug treatment options for SARS-CoV-2, its clinical characteristics, and therapies involving a combination of Chinese and Western medicine, the efficacy of chloroquine phosphate in the treatment of COVID-19 associated pneumonia according to clinical studies, and reflections on the system of reserve medical supplies for public health emergencies. 2020-03-18
Characteristics of and Public Health Responses to the Coronavirus Disease 2019 Outbreak in China. Meanwhile, it is also crucial to speed up the development of vaccines and drugs for treatment, which will enable us to defeat COVID-19 as soon as possible. 2020-03-22
[Dynamic changes of chest CT imaging in patients with corona virus disease-19 (COVID-19)]. The chest CT images of patients with COVID-19 have certain characteristics with dynamic changes, which are of value for monitoring disease progress and clinical treatment. 2020-03-16
[Management of corona virus disease-19 (COVID-19): the Zhejiang experience]. Based on the present expert consensus carried out by National Health Commission and National Administration of Traditional Chinese Medicine, our team summarized and established an effective treatment strategy centered on “Four-Anti and Two-Balance” for clinical practice. […] Meanwhile, integrated multidisciplinarypersonalized treatment was recommended to improve therapeutic effect. […] Early antiviral treatment could alleviate disease severity and prevent illness progression, and we found lopinavir/ritonavir combined with abidol showed antiviraleffects in COVID-19. […] The artificial liver blood purification system could rapidly remove inflammatory mediators and block cytokine storm.Moreover, it also favoredthe balance of fluid, electrolyte and acid-base and thus improved treatment efficacy in critical illness. […] Conservative oxygen therapy was preferred and noninvasive ventilation was not recommended. […] We also integrated Chinese medicine in treatment to promote disease rehabilitation through classification methods of traditional Chinese medicine. […] However, since COVID-19 was a newly emerging disease, more work was warranted to improve strategies of prevention, diagnosis and treatment for COVID-19. 2020-03-16
[The treatment proposal for the patients with breast diseases in the central epidemic area of 2019 coronavirus disease]. The characteristics including high contagiousness, herd susceptibility and clinical phenotype diversity, made a serious influence on people’s daily life and rountine therapy for other diseases. […] In the central epidemic area of COVID-19, Hubei province, especially Wuhan, the clinical specialists of breast diseases should consider all of the following factors comprehensively: the prevention of COVID-19, the diagnosis and treatment of breast diseases and the accessibility of medical resources. […] Besides, we should select the appropriate therapy and optimize treatment process so as to prevent the propagation and cross infection of COVID-19 as well as manage the breast diseases without delay. […] Therefore, we carried out some management proposals of the patients with breast diseases in the central epidemic area during the epidemic of COVID-19 on the basis of conventional treatment guidelines and clinical experiences. 2020-02-25
[Surgical treatment strategy for digestive system malignancies during the outbreak of novel coronavirus pneumonia]. After the outbreak of this disease, the overwhelming majority of cities have launched the “first level response” and the regular diagnosis and treatment of cancer patients are greatly affected. […] The epidemic of novel coronavirus pneumonia poses new challenges to diagnosis and treatment of the patients with digestive system malignancies. […] Based on the fully understanding of the characteristics of digestive system tumors, we should change the treatment strategy and adopt more reasonable treatment strategy timely during the epidemic period to minimize the adverse effects of the epidemic of novel coronavirus pneumonia on the treatment. 2020-02-25
Emergence of Novel Coronavirus 2019-nCoV: Need for Rapid Vaccine and Biologics Development. The collaborative efforts of researchers are needed to fill the knowledge gaps about this new virus, to develop the proper diagnostic tools, and effective treatment to combat this infection. 2020-02-26
Systematic Comparison of Two Animal-to-Human Transmitted Human Coronaviruses: SARS-CoV-2 and SARS-CoV. The goal of this work is to systematically review and compare between SARS-CoV and SARS-CoV-2 in the context of their virus incubation, originations, diagnosis and treatment methods, genomic and proteomic sequences, and pathogenic mechanisms. 2020-03-23
[What are the highlights of “Diagnosis and treatment of Disease 2019 novel coronavirus infection suitable for Military support Hubei medical team”]. According to " the Diagnosis and Treatment of New Coronavirus Pneumonia "(6th edition) of the National Health Commission of the People’s Republic of China, a new guideline for the diagnosis and treatment of 2019 novel coronavirus infection suitable for the military (first trial version) was established. […] Some unique opinions and suggestions are put forward in terms of disease name, diagnosis criteria, antiviral treatment, glucocorticoid application, etc. […] This article will make a proper interpretation in order to understand the guideline better and help guide the diagnosis and treatment of diseases. 2020-02-26
2019 Novel Coronavirus (COVID-19) Pneumonia: Serial Computed Tomography Findings. After treatment, the lesions were shown to be almost absorbed leaving the fibrous lesions. 2020-03-24
[Health management of breast cancer patients outside the hospital during the outbreak of 2019 novel coronavirus disease]. In order to prevent cluster outbreaks, the government strengthened the management and control of personnel mobility, which had a great impact on the examination and treatment of breast cancer patients. […] If necessary, after professional discussion and communication between doctors and patients online or offline, the hospital visiting time should be delayed through seeking alternative treatment schemes, and psychological counseling for patients should be paid attention to at the same time. 2020-02-26
[Chemotherapy strategy for colorectal cancer under the outbreak of novel coronavirus pneumonia]. The outbreak of novel coronavirus pneumonia (NCP) makes the medical treatment of colorectal cancers difficult. […] For metastatic colorectal cancer (CRC) patients, maintenance therapy is the optimal choice. […] Adjuvant chemotherapy should reduce the intensity of treatment and shorten the therapy time. 2020-02-26
The 2019 novel coronavirus resource. In this report, we provide comprehensive descriptions on data deposition, management, release and utility in 2019nCoVR, laying important foundations in aid of studies on virus classification and origin, genome variation and evolution, fast detection, drug development and pneumonia precision prevention and therapy. 2020-03-12
The neuroinvasive potential of SARS-CoV2 may play a role in the respiratory failure of COVID-19 patients. Awareness of this may have a guiding significance for the prevention and treatment of the SARS-CoV-2-induced respiratory failure. 2020-03-18
Development and clinical application of a rapid IgM-IgG combined antibody test for SARS-CoV-2 infection diagnosis. There is an urgent need for an accurate and rapid test method to quickly identify a large number of infected patients and asymptomatic carriers to prevent virus transmission and assure timely treatment of patients. 2020-04-13
[Surgical treatment for esophageal cancer during the outbreak of COVID-19]. It has also brought great challenges to the treatment of patients with cancer. […] The selection of surgical procedures and perioperative managements of esophageal cancer require all thoracic surgeons work together to figure out a reasonable system of surgical treatment and emergency response. 2020-02-27
Coronavirus Disease 2019 (COVID-19) and pregnancy: what obstetricians need to know. Principles of management of coronavirus disease 2019 in pregnancy include early isolation, aggressive infection control procedures, oxygen therapy, avoidance of fluid overload, consideration of empiric antibiotics (secondary to bacterial infection risk), laboratory testing for the virus and coinfection, fetal and uterine contraction monitoring, early mechanical ventilation for progressive respiratory failure, individualized delivery planning, and a team-based approach with multispecialty consultations. 2020-04-15
Update: Public Health Response to the Coronavirus Disease 2019 Outbreak - United States, February 24, 2020. Although these measures might not prevent widespread transmission of the virus in the United States, they are being implemented to 1) slow the spread of illness; 2) provide time to better prepare state and local health departments, health care systems, businesses, educational organizations, and the general public in the event that widespread transmission occurs; and 3) better characterize COVID-19 to guide public health recommendations and the development and deployment of medical countermeasures, including diagnostics, therapeutics, and vaccines. 2020-03-02
[Treatment of pancreatic diseases and prevention of infection during outbreak of 2019 coronavirus disease]. Objective: To explorethe proper protective measures for pancreaticdiseases treatment during theoutbreak of 2019 coronavirus disease(COVID-19). Method: Clinical data of four cases of patients that suffered COVID-19from February 2(nd), 2020 to February 9(th), 2020 in pancreatic surgery were reviewed.After the first patientscuffednosocomial infection of COVID-19, the general protective measures in our department wereupdated.Only one patient was admitted to each room alone, with no more than one caregiver.The body temperature of care givers was measuredtwice a day.Primary protections were applied to all staff.The floor was sterilized using disinfectant with an effective chlorine concentration of 1000 mg/L.The protective measures for interventional procedures were as follow.Primary protection was applied to the operators ofcentral venipuncture catheter, percutaneous abdominal/pleural drainage, percutaneous retroperitoneal drainage, percutaneous transhepatic cholangial drainage and other surgical procedures with local anesthesiaand epidural anesthesia.Secondary protection was applied to the operators of endoscopic retrograde cholangiopancreatography and surgical procedures with general anesthesia. Results: During Feb 2(nd), 2020 to Feb 9(th), 2020, four patients in our department were diagnosed with COVID-19, of which one was died of COVID-19, two were cured, and one is still in hospital for COVID-19. 2020-02-28
Clinical characteristics of hospitalized patients with SARS-CoV-2 infection: A single arm meta-analysis. We aim to summarize reliable evidence of evidence-based medicine for the treatment and prevention of the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) by analyzing all the published studies on the clinical characteristics of patients with SARS-CoV-2. 2020-03-18
Clinical trial analysis of 2019-nCoV therapy registered in China. With more and more patients diagnosed, China has carried out more than 100 clinical studies of new coronavirus infection, including antiviral drugs, antimalarial drugs, glucocorticoids, plasma therapy, virus vaccine, and other Western drugs, while Chinese medicine research accounted for half of the studies. […] Although the final results of studies will take a long time to complete, the interim research data may provide some help for the current urgent demand for drug treatment. 2020-03-05
[Treatment strategies of Budd-Chiari syndrome during the epidemic period of 2019 coronavirus disease]. In addition to supporting the frontline actively, medical workers in general surgery spare no efforts in making good diagnosis and treatment of specialized diseases by optimizing treatment process, providing medical advice online, mastering indications of delayed operation and emergency operation reasonably, etc. […] However, instead of continuing the traditional treatment, a new management system should be developed. […] Based on the characteristics of Budd-Chiari syndrome patients in China and our experience, we divide the patients into ordinary and critical cases, and treatment strategies suitable for the epidemic period of COVID-19 are put forward for reference and discussion by physicians. 2020-02-28
[Discussion on diagnosis and treatment of hepatobiliary malignancies during the outbreak of novel coronavirus pneumonia]. During the epidemic period, the routine diagnosis and treatment of tumor patients was affected with varying degrees. […] In this special period, we performed the superiority of the multi-disciplinary team of diagnosis and treatment, achieved accurate diagnosis and treatment of patients with hepatobiliary malignant tumors, provided support for these patients with limited medical resources, and helped them to survive during the epidemic period.On the basis of fully understanding the new coronavirus pneumonia, the treatment strategy should be changed timely during the epidemic, and more appropriate treatment methods should be adopted to minimize the adverse effect of the epidemic on tumor treatment. 2020-02-28
Clinical and computed tomographic imaging features of novel coronavirus pneumonia caused by SARS-CoV-2. A retrospective analysis was performed on the imaging findings of patients confirmed with COVID-19 pneumonia who had chest CT scanning and treatment after disease onset. […] CT scanning provides important bases for early diagnosis and treatment of NCP. 2020-04-06
Potential Rapid Diagnostics, Vaccine and Therapeutics for 2019 Novel Coronavirus (2019-nCoV): A Systematic Review. Rapid diagnostics, vaccines and therapeutics are important interventions for the management of the 2019 novel coronavirus (2019-nCoV) outbreak. […] A number of novel compounds as well as therapeutics licensed for other conditions appear to have in vitro efficacy against the 2019-nCoV. 2020-04-11
[The keypoints in treatment of the critical coronavirus disease 2019 patient]. The treatment of critically ill patients with coronavirus disease 2019(COVID-19) faces compelling challenges. […] In this issue, we’d like to share our first-line treatment experience in treating COVID-19. […] Nutritional support is the basis of treatment. […] It’s important to establish individual therapy regimens and to evaluate, monitor and adjust dynamically. 2020-02-29
[Recommendations for the regulation of medical practices of burn treatment during the outbreak of the coronavirus disease 2019]. China has formally included the 2019-nCoV in the statutory notification and control system for infectious diseases according to the Law of the People’s Republic of China on the Prevention and Treatment of Infectious Diseases. […] According to the guidelines on the diagnosis and treatment of COVID-19 (6(th) trial edition), the latest relative literature at home and abroad, the features of the COVID-19, recommendations for the COVID-19 prevention and control issued by the National Health Commission of China, and management experience of diagnosis and treatment in the related disciplines, we put forward recommendations for the medical practices of burn treatment during the outbreak of the COVID-19 in outpatient and emergency treatment, inpatient treatment, operation and ward management, etc. […] We hope these recommendations could benefit the professionals of the same occupation as us and related hospital managers, improve the treatment of burn during the outbreak of the COVID-19, and avoid or reduce the risk of infection of medical staff . 2020-02-29
[Medical diagnosis and treatment strategies for malignant tumors of the digestive system during the outbreak of novel coronavirus pneumonia]. Since the outbreak of novel coronavirus pneumonia in December 2019, the diagnosis and treatment of patients with cancer have been facing great challenges. […] Although oncologists are not fighting on the front line to against the epidemic, during this special period, we should not only protect patients, their families and medical staff from the infection of novel Coronavirus, but also minimize the impact of the epidemic on the diagnosis and the treatment of patients with cancer. […] Combining the guidelines for diagnosis and treatment of tumors with our clinical experience, in this epidemic period, we discuss the strategies for diagnosis, treatment, and follow-up of malignant tumors of the digestive system in this article. 2020-02-29
Characteristics of COVID-19 infection in Beijing. By Feb 10, 2020, 262 patients were transferred from the hospitals across Beijing to the designated hospitals for special treatment of the COVID-19 infected by Beijing emergency medical service. 2020-04-06
[Pregnant women with new coronavirus infection: a clinical characteristics and placental pathological analysis of three cases]. By the end of February 25, 2020, none of the three patients developed severe 2019-nCoV pneumonia or died(two patients had been cured and discharged, while another one had been transferred to a square cabin hospital for isolation treatment). 2020-03-02
[Advances in the research of cytokine storm mechanism induced by Corona Virus Disease 2019 and the corresponding immunotherapies]. Corona Virus Disease 2019 (COVID-19) has seriously affected the treatment of patients and social stability. […] At present, some therapies such as interleukin-6 antibody blocker, stem cell therapy, and transfusion of convalescent plasma have been applied to counteract the cytokine storm and have made some progress. 2020-03-02
Coronavirus disease (COVID-19) and neonate: What neonatologist need to know. The treatment strategy for children with Coronavirus disease (COVID-19) is based on adult experience. 2020-03-16
Therapeutic strategies in an outbreak scenario to treat the novel coronavirus originating in Wuhan, China. While vaccine research should be pursued intensely, there exists today no therapy to treat 2019-nCoV upon infection, despite an urgent need to find options to help these patients and preclude potential death. […] I consider the options of drug repurposing, developing neutralizing monoclonal antibody therapy, and an oligonucleotide strategy targeting the viral RNA genome, emphasizing the promise and pitfalls of these approaches. […] Finally, I advocate for the fastest strategy to develop a treatment now, which could be resistant to any mutations the virus may have in the future. […] Such a treatment could help infected patients before a protective vaccine is developed and widely available in the coming months to year(s). 2020-03-20
[Clinical analysis of 31 cases of 2019 novel coronavirus infection in children from six provinces (autonomous region) of northern China]. Objective: To analyze the epidemiological history, clinical manifestations, treatment and the short-term prognosis of 31 cases of 2019 novel coronavirus(2019-nCoV) infection in children from six provinces (autonomous region) in northern China. Methods: A retrospective analysis of the epidemiological history, clinical symptoms, signs, laboratory examinations, chest imaging, treatment and the short-term prognosis of 31 cases of 2019-nCoV was conducted. […] After receiving supportive treatment, the viral nucleic acid turned negative in 25 cases within 7-23 days. […] After general treatment, the short-term prognosis is good. 目的: 分析中国北方6省(自治区)儿童2019新型冠状病毒(2019 novel coronavirus, 2019-nCoV)感染者的流行病学史、临床表现、治疗及近期预后。 2020-03-02
[Cause analysis and treatment strategies of “recurrence” with novel coronavirus pneumonia (covid-19) patients after discharge from hospital]. For those patients who can’t completely deoxygenate for a long time after hospitalization, individualized treatment methods and different discharge evaluation criteria should be adopted to ensure the complete cure of patients and prevent recurrencing after discharge from hospital. 2020-03-02
[Diagnostic and therapeutic strategies of lung cancer patients during the outbreak of 2019 novel coronavirus disease (COVID-19)]. The diagnosis and treatment of lung cancer patients have been challenged greatly because of extraordinary public health measures since the lung cancer patients are a high-risk population during the COVID-19 outbreak period. 2020-03-02
Persistence and clearance of viral RNA in 2019 novel coronavirus disease rehabilitation patients. The effects of cluster of differentiation 4 (CD4)+ T lymphocytes, inflammatory indicators, and glucocorticoid treatment on viral nucleic acid clearance were analyzed. […] In the 292 confirmed cases, 66 patients recovered after treatment and were included in our study. […] After in-hospital treatment, patients’ inflammatory indicators decreased with improved clinical condition. […] The duration of viral RNA detection from oropharyngeal swabs and fecal samples in the glucocorticoid treatment group was longer than that in the non-glucocorticoid treatment group (15 days vs. […] 8.0 days, respectively; t = 2.550, P = 0.013) and the duration of viral RNA detection in fecal samples in the glucocorticoid treatment group was longer than that in the non-glucocorticoid treatment group (20 days vs. 11 days, respectively; t = 4.631, P < 0.001). […] Because of the delayed clearance of viral RNA in the glucocorticoid treatment group, glucocorticoids are not recommended in the treatment of COVID-19, especially for mild disease. 2020-03-02
Analysis of factors associated with disease outcomes in hospitalized patients with 2019 novel coronavirus disease. Associated results will be used to evaluate the prognosis and to find the optimal treatment regimens for COVID-19 pneumonia. 2020-03-02
[Clinical characteristics and outcomes of 112 cardiovascular disease patients infected by 2019-nCoV]. There was no significant difference in the proportion of ACEI/ARB medication between the critical group and the general group or between non-survivors and survivors (all P>0.05). Conclusion: COVID-19 patients combined with CVD are associated with a higher risk of mortality. 2020-03-02
Antiviral Action of Tryptanthrin Isolated from Strobilanthes cusia Leaf against Human Coronavirus NL63. Strobilanthes cusia (Nees) Kuntze is a Chinese herbal medicine used in the treatment of respiratory virus infections. 2020-03-03
[Individualized treatment recommendations for lung cancer patients at different stages of treatment during the outbreak of 2019 novel coronavirus disease epidemic]. In order to achieve the overall victory of the 2019 novel coronavirus disease epidemic in this ‘war’, especially to prevent the disease recurrence from rebounding during the resumption of labor, the government has not loosened any control of personnel mobility, which has obviously affected the normal examination and treatment of lung cancer patients under the influence of this epidemic. […] It is necessary to provide more appropriate individualized treatment recommendations for patients with lung cancer based on the epidemic situation of the patient’s location and in combination with the patient’s own condition. […] Through active prevention of infection, timely conversion of treatment strategies, online and offline joint control, and positive psychological counseling, we significantly hope to help patients with lung cancer to survive this difficult period. 2020-03-03
[Expert recommendations on the management of patients with advanced non-small cell lung cancer during epidemic of COVID-19 (Trial version)]. During the epidemic of COVID-19, We recommended that patients with advanced NSCLC should be treated as outpatients as possible at the nearest medical center; Patients who need to be hospitalized for antitumor treatment should be excluded from COVID-19 infection; More intensive attention should be paid to identification of COVID-19-related symptoms and adverse reactions caused by the malignancy or antitumor treatments. […] Stronger personal protection should be made for advanced NSCLC patients; An intentional postponing of antitumor treatment should be considered according to patient performance status. […] Treatment strategies should be made according to different types of advanced NSCLC patients and efficacy and toxicity of drugs. 2020-03-03
Broad Spectrum Antiviral Agent Niclosamide and Its Therapeutic Potential. The recent outbreak of coronavirus disease 2019 (COVID-19) highlights an urgent need for therapeutics. […] In this brief review, we summarize the broad antiviral activity of niclosamide and highlight its potential clinical use in the treatment of COVID-19. 2020-04-09
Epidemiologic Features and Clinical Course of Patients Infected With SARS-CoV-2 in Singapore. Clinical course was summarized, including requirement for supplemental oxygen and intensive care and use of empirical treatment with lopinavir-ritonavir. […] Some patients required supplemental oxygen and had variable clinical outcomes following treatment with an antiretroviral agent. 2020-03-17
Understanding SARS-CoV-2-Mediated Inflammatory Responses: From Mechanisms to Potential Therapeutic Tools. Currently there is no effective antiviral therapy for SARS-CoV-2 infection, which frequently leads to fatal inflammatory responses and acute lung injury. […] In the absence of a proven clinical FcR blocker, the use of intravenous immunoglobulin to block FcR activation may be a viable option for the urgent treatment of pulmonary inflammation to prevent severe lung injury. […] Such treatment may also be combined with systemic anti-inflammatory drugs or corticosteroids. 2020-03-03
Angiotensin receptor blockers as tentative SARS-CoV-2 therapeutics. Therapeutics that may assist to contain its rapid spread and reduce its high mortality rates are urgently needed. […] A tentative suggestion based on existing therapeutics, which would likely be resistant to new coronavirus mutations, is to use available angiotensin receptor 1 (AT1R) blockers, such as losartan, as therapeutics for reducing the aggressiveness and mortality from SARS-CoV-2 virus infections. […] This commentary elaborates on the idea of considering AT1R blockers as tentative treatment for SARS-CoV-2 infections, and proposes a research direction based on datamining of clinical patient records for assessing its feasibility. 2020-03-04
[Comparison of heart failure and 2019 novel coronavirus pneumonia in chest CT features and clinical characteristics]. In heart failure group, the ratio of the expansion of small pulmonary veins was also higher (3/7 vs. 0, P=0.013), and the lung lesions can be significantly improved after effective anti-heart failure treatment. 2020-03-04
Coronavirus Disease 2019 (COVID-19): Role of Chest CT in Diagnosis and Management. These patients were isolated and obtained treatment. 2020-03-04
[Mental health survey of 230 medical staff in a tertiary infectious disease hospital for COVID-19]. From February 7 to 14, 2020, 246 medical staff were investigated who participated in the treatment of COVID-19 using cluster sampling , and received 230 responses, with a recovery rate of 93.5%. Results: The incidence of anxiety in medical staff was 23.04% (53/230), and the score of SAS was (42.91 ± 10.89). 2020-03-04
[Investigation and analysis on characteristics of a cluster of COVID-19 associated with exposure in a department store in Tianjin]. The median of the incubation period of customer cases was 6 days, and the median of the interval between onset and medical treatment of customer cases was 7 days. Conclusion: This was a cluster epidemic of COVID-19, which might be associated with the exposure in the department store. 2020-03-05
[The differential diagnosis of pulmonary infiltrates in cancer patients during the outbreak of the 2019 novel coronavirus disease]. Considering the negative result of nuclear acid testing, this patient was presumptively diagnosed as viral pneumonia and an experiential anti-infection treatment had been prescribed for him. Conclusions: The 2019 novel coronavirus disease (COVID-19) complicates the clinical scenario of pulmonary infiltrates in cancer patients. […] Active anti-infection treatment and surveillance of patient condition should be initiated if infectious disease is considered. 目的: 结合化疗后出现肺内磨玻璃影的淋巴瘤患者的临床特征,分析当前新型冠状病毒肺炎(COVID-19)疫情期间肿瘤患者出现肺内浸润的鉴别诊断和临床处理思路。 2020-03-05
Perspectives on monoclonal antibody therapy as potential therapeutic intervention for Coronavirus disease-19 (COVID-19). Hence, the research advancements on SARS-CoV treatment might help scientific community in quick understanding of this virus pathogenesis and develop effective therapeutic/prophylactic agents to treat and prevent this infection. […] The therapeutic potential of monoclonal antibodies has been well recognized in the treatment of many diseases. 2020-03-24
The outbreak of COVID-19: An overview. Currently, there is no definite treatment for COVID-19 although some drugs are under investigation. 2020-03-18
Emergency management for preventing and controlling nosocomial infection of 2019 novel coronavirus: implications for the dermatology department. Due to the current lack of specific treatment and the risk of transmission during the viral incubation period, infection prevention and control of 2019-nCoV are both urgent and critical to global health. 2020-03-11
The transmission and diagnosis of 2019 novel coronavirus infection disease (COVID-19): A Chinese perspective. The Chinese government has taken emergency measures to control the outbreak and has undertaken initial steps in the diagnosis and treatment of 2019 novel coronavirus infection disease (COVID-19). 2020-03-12
Transmission dynamics of the COVID-19 outbreak and effectiveness of government interventions: A data-driven analysis. Isolation and protective procedures would be less effective as more cases accrue, so the optimization of the treatment plan and the development of specific drugs would be of more importance. […] Evidence from the four-phase stringent measures showed that it was significant to ensure early detection, early isolation, early treatment, adequate medical supplies, patients’ being admitted to designated hospitals, and comprehensive therapeutic strategy. 2020-03-24
SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor. A TMPRSS2 inhibitor approved for clinical use blocked entry and might constitute a treatment option. 2020-04-01
Insights into the Recent 2019 Novel Coronavirus (SARS-CoV-2) in Light of Past Human Coronavirus Outbreaks. The future of human CoV outbreaks will not only depend on how the viruses will evolve, but will also depend on how we develop efficient prevention and treatment strategies to deal with this continuous threat. 2020-03-09
Middle East respiratory syndrome. This Seminar provides an update on the current knowledge and perspectives on MERS epidemiology, virology, mode of transmission, pathogenesis, diagnosis, clinical features, management, infection control, development of new therapeutics and vaccines, and highlights unanswered questions and priorities for research, improved management, and prevention. 2020-04-13
[Analysis of the pregnancy outcomes in pregnant women with COVID-19 in Hubei Province].
  1. In the treatment of uterine contraction fatigue, carbetocin or carboprost tromethamine was used more in cesarean section for pregnant women with COVID-19 (1.3±0.6), compared with Non-COVID-19 group (0.5±0.7), the difference was statistically significant (P=0.001). Conclusions: If there is an indication for obstetric surgery or critical illness of COVID-19 in pregnant women, timely termination of pregnancy will not increase the risk of premature birth and asphyxia of the newborn, but it is beneficial to the treatment and rehabilitation of maternal pneumonia.
2020-03-08
[The preliminary analysis on the characteristics of the cluster for the Corona Virus Disease]. Whatever happens, screening and isolating close contacts remains essential except for clinical treatment during the epidemic. 2020-03-08
[Healing the schism between public health and medicine, promoting the integration of prevention and treatment]. The outbreak of coronavirus disease 2019 (COVID-19) has opened a public class on the treatment, prevention and control of infectious diseases for the Chinese citizens. […] In future, when combating with novel infectious diseases and public health emergencies, the response capacity of public health system and treatment capacity of clinical system will be significantly improved, while the situation on insufficient integration of prevention and treatment is bound to be reversed. 2020-03-08
Of chloroquine and COVID-19. Recent publications have brought attention to the possible benefit of chloroquine, a broadly used antimalarial drug, in the treatment of patients infected by the novel emerged coronavirus (SARS-CoV-2). 2020-04-15
Discovering drugs to treat coronavirus disease 2019 (COVID-19). Several drugs such as chloroquine, arbidol, remdesivir, and favipiravir are currently undergoing clinical studies to test their efficacy and safety in the treatment of coronavirus disease 2019 (COVID-19) in China; some promising results have been achieved thus far. 2020-03-16
Repurposing of clinically approved drugs for treatment of coronavirus disease 2019 in a 2019-novel coronavirus (2019-nCoV) related coronavirus model. Medicines for the treatment of 2019-novel coronavirus (2019-nCoV) infections are urgently needed. […] This study aims to repurpose the clinically approved drugs for the treatment of coronavirus disease 2019 (COVID-19) in a 2019-nCoV related coronavirus model. […] The viral RNA yield in cells treated with 10 μmol/L CEP was 15,393-fold lower than in cells without CEP treatment ([6.48 ± 0.02] × 10vs. […] Our results strongly suggest that CEP is a wide-spectrum inhibitor of pan-betacoronavirus, and clinical trial of CEP for treatment of 2019-nCoV infection is warranted. 2020-03-09
Effectiveness of glucocorticoid therapy in patients with severe novel coronavirus pneumonia: protocol of a randomized controlled trial. The effectiveness of adjunctive glucocorticoid therapy uses in the management of 2019-nCoV infected patients with severe lower respiratory tract infections is not clear, and warrants further investigation. 2020-03-09
Compounds with therapeutic potential against novel respiratory 2019 coronavirus. Therapeutics that target the coronavirus alone might not be able to reverse highly pathogenic infections. 2020-03-10
Topological dynamics of the 2015 South Korea MERS-CoV spread-on-contact networks. We present several distinct features of MERS transmission by employing a comprehensive approach in network research to examine both the traced relationship matrix of infected individuals and their bipartite transmission routes among healthcare facilities visited for treatment. 2020-03-19
[The differential diagnosis for novel coronavirus pneumonia and similar lung diseases in general hospitals]. The National Health Commission, PRC has revised the consensus on diagnosis and treatment seven times in a short period of time, indicating the growing understanding of the disease. […] We were trying to find the similarities and differences among them, and to identify clues to the diagnosis of novel coronavirus pneumonia, so as to ensure accurate diagnosis and treatment. 2020-03-10
[Clinical characteristics and influencing factors of patients with novel coronavirus pneumonia combined with liver injury in Shaanxi region]. The liver function of all patients had recovered within one week after conventional liver protection treatment. Conclusion: COVID-19 combined with liver function injury may be due to the slight elevation of transaminase, mostly around the second week of the disease course. 2020-03-10
Immediate Psychological Responses and Associated Factors during the Initial Stage of the 2019 Coronavirus Disease (COVID-19) Epidemic among the General Population in China. Specific up-to-date and accurate health information (e.g., treatment, local outbreak situation) and particular precautionary measures (e.g., hand hygiene, wearing a mask) were associated with a lower psychological impact of the outbreak and lower levels of stress, anxiety, and depression (p < 0.05). Conclusions: During the initial phase of the COVID-19 outbreak in China, more than half of the respondents rated the psychological impact as moderate-to-severe, and about one-third reported moderate-to-severe anxiety. 2020-03-18
Development of a Laboratory-safe and Low-cost Detection Protocol for SARS-CoV-2 of the Coronavirus Disease 2019 (COVID-19). Our newly developed protocol should be helpful for a first-hand screening of the asymptomatic virus-carriers for further prevention of transmission and early intervention and treatment for the rapidly propagating virus. 2020-03-11
2019 novel coronavirus (2019-nCoV) outbreak: A new challenge. Following the public-health emergency of international concern (PHEIC) declared by the World Health Organization (WHO) on 30 January 2020 and the recent outbreak caused by 2019 novel coronavirus (2019-nCoV) [officially renamed severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)] in China and 29 other countries, we aimed to summarise the clinical aspects of the novelBetacoronavirus disease (COVID-19) and its possible clinical presentations together with suggested therapeutic algorithms for patients who may require antimicrobial treatment. 2020-04-06
Harnessing the immune system via FcγR function in immune therapy: a pathway to next-gen mAbs. The use of mAb therapeutics has also revealed a “scaffolding” role for FcγR which, in different contexts, may either underpin the therapeutic mAb action such as immune agonism or trigger catastrophic adverse effects. 2020-04-14
CT Manifestations of Novel Coronavirus Pneumonia: A Case Report In this case report, we aim to define the chest computed tomography findings of 2019-novel coronavirus associated with pneumonia and its successful resolution after treatment. […] Despite the given treatment, her body temperature rose to 39.2°C and she was referred to our clinic for further evaluation. 2020-04-15
Dysregulation of immune response in patients with COVID-19 in Wuhan, China. Surveillance of NLR and lymphocyte subsets is helpful in the early screening of critical illness, diagnosis and treatment of COVID-19. 2020-04-03
Chest computed tomography in children with COVID-19 respiratory infection. Three of these five had CT abnormality on the first CT scan (at 2 days, 4 days and 9 days, respectively, after onset of symptoms) in the form of patchy ground-glass opacities; all normalised during treatment. 2020-03-12
Rapid Identification of Potential Inhibitors of SARS-CoV-2 Main Protease by Deep Docking of 1.3 Billion Compounds. The recently emerged 2019 Novel Coronavirus (SARS-CoV-2) and associated COVID-19 disease cause serious or even fatal respiratory tract infection and yet no approved therapeutics or effective treatment is currently available to effectively combat the outbreak. […] This urgent situation is pressing the world to respond with the development of novel vaccine or a small molecule therapeutics for SARS-CoV-2. 2020-03-26
A report of clinical diagnosis and treatment of nine cases of coronavirus disease 2019. However, there is no unified standard for the diagnosis and treatment of COVID-19. […] In the retrospective analysis, we report nine cases of COVID-19, describe the history of contact, clinical manifestations, the course of diagnosis and clinical treatment before, during and after treatment. 2020-03-16
COVID-19: An Update on the Epidemiological, Clinical, Preventive and Therapeutic Evidence and Guidelines of Integrative Chinese-Western Medicine for the Management of 2019 Novel Coronavirus Disease. Similar to outbreaks of other newly identified virus, there is no proven regimen from conventional medicine and most reports managed the patients with lopinavir/ritonavir, ribavirin, beta-interferon, glucocorticoid and supportive treatment with remdesivir undergoing clinical trial. […] In China, Chinese medicine is proposed as a treatment option by national and provincial guidelines with substantial utilization. […] We reviewed the latest national and provincial clinical guidelines, retrospective cohort studies, and case series regarding the treatment of COVID-19 by add-on Chinese medicine. 2020-03-13
A Review of Coronavirus Disease-2019 (COVID-19). Treatment is essentially supportive; role of antiviral agents is yet to be established. 2020-03-23
Soluble angiotensin-converting enzyme 2: a potential approach for coronavirus infection therapy? We thought that it is timely to explain the connection between the SARS-CoV, SARS-CoV-2, ACE2 and the rationale for soluble ACE2 as a potential therapy. 2020-03-18
Risk Factors Associated With Acute Respiratory Distress Syndrome and Death in Patients With Coronavirus Disease 2019 Pneumonia in Wuhan, China. Epidemiological, demographic, clinical, laboratory, management, treatment, and outcome data were also collected and analyzed. […] Among patients with ARDS, treatment with methylprednisolone decreased the risk of death (HR, 0.38; 95% CI, 0.20-0.72). […] Moreover, treatment with methylprednisolone may be beneficial for patients who develop ARDS. 2020-03-17
A Diabetic Patient With 2019-nCoV (COVID-19) Infection Who Recovered and Was Discharged From Hospital. The patient showed improvement both clinically and on computed tomography imaging at discharged after 2 weeks’treatment. 2020-04-16
The origin, transmission and clinical therapies on coronavirus disease 2019 (COVID-19) outbreak - an update on the status. In this review, we summarized the latest research progress of the epidemiology, pathogenesis, and clinical characteristics of COVID-19, and discussed the current treatment and scientific advancements to combat the epidemic novel coronavirus. 2020-03-19
COVID-19 spike-host cell receptor GRP78 binding site prediction. These nine residues can be used to develop therapeutics specific against COVID-19. 2020-04-16
Coronavirus disease 2019: What we know? The purpose of this review is primarily to review the pathogen, clinical features, diagnosis, and treatment of COVID-19, but also to comment briefly on the epidemiology and pathology based on the current evidence. 2020-03-29
Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study. Demographic, clinical, treatment, and laboratory data, including serial samples for viral RNA detection, were extracted from electronic medical records and compared between survivors and non-survivors. 2020-04-03
New insights on the antiviral effects of chloroquine against coronavirus: what to expect for COVID-19? In the absence of a known efficient therapy and because of the situation of a public-health emergency, it made sense to investigate the possible effect of chloroquine/hydroxychloroquine against SARS-CoV-2 since this molecule was previously described as a potent inhibitor of most coronaviruses, including SARS-CoV-1. […] Preliminary trials of chloroquine repurposing in the treatment of COVID-19 in China have been encouraging, leading to several new trials. 2020-04-04
Clinical features of COVID-19 in elderly patients: A comparison with young and middle-aged patients. The Lopinavir and Ritonavir Tablets, Chinese medicine, oxygen therapy, and mechanical ventilation were statistically different in the elderly group and the young and middle-aged group, and the P values were all <0.05. 2020-04-01
Clinical progression of patients with COVID-19 in Shanghai, China. Patients who were transferred to intensive care units (ICU) had significantly longer duration of fever as compared to those not in ICU (31 days v.s. 9 days after onset of symptoms, respectively, P <0.0001). […] The clinical progression pattern suggests that early control of viral replication and application of host-directed therapy in later stage is essential to improve the prognosis of CVOID-19. 2020-04-16
Arbidol combined with LPV/r versus LPV/r alone against Corona Virus Disease 2019: A retrospective cohort study. We aimed to compare arbidol and lopinavir/ritonavir(LPV/r) treatment for patients with COVID-19 with LPV/r only. 2020-04-16
Prominent changes in blood coagulation of patients with SARS-CoV-2 infection. Up to now, clinical features and treatment of patients infected with SARS-CoV-2 have been reported in detail. 2020-04-01
Potential preanalytical and analytical vulnerabilities in the laboratory diagnosis of coronavirus disease 2019 (COVID-19). Overall, potential RT-PCR vulnerabilities include general preanalytical issues such as identification problems, inadequate procedures for collection, handling, transport and storage of the swabs, collection of inappropriate or inadequate material (for quality or volume), presence of interfering substances, manual errors, as well as specific aspects such as sample contamination and testing patients receiving antiretroviral therapy. 2020-04-01
Diagnosis and clinical management of severe acute respiratory syndrome Coronavirus 2 (SARS-CoV-2) infection: an operational recommendation of Peking Union Medical College Hospital (V2.0). To standardize the diagnosis and treatment of this new infectious disease, an operational recommendation for the diagnosis and management of SARS-CoV-2 infection is developed by Peking Union Medical College Hospital. 2020-03-17
A systematic review on the efficacy and safety of chloroquine for the treatment of COVID-19. As of this time, there is no known effective pharmaceutical treatment, although it is much needed for patient contracting the severe form of the disease. […] The aim of this systematic review was to summarize the evidence regarding chloroquine for the treatment of COVID-19. 2020-03-16
Asymptomatic carrier state, acute respiratory disease, and pneumonia due to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2): Facts and myths. To date, effective treatment is lacking; however, clinical trials investigating the efficacy of several agents, including remdesivir and chloroquine, are underway in China. 2020-04-09
Patients of COVID-19 may benefit from sustained lopinavir-combined regimen and the increase of eosinophil may predict the outcome of COVID-19 progression. Levels of potassium, albumin, lymphocyte were low, but increased persistently after treatment. 2020-03-16
Clinical characteristics of refractory COVID-19 pneumonia in Wuhan, China. Refractory COVID-19 patients were more likely to receive oxygen, mechanical ventilation, expectorant, and adjunctive treatment including corticosteroid, antiviral drugs and immune enhancer (P<0.05). 2020-03-16
[Management strategies for patients with gynecological malignancies during the outbreak of COVID19]. Objective: To explore the management strategies for patients with gynecological malignant tumors during the outbreak and transmission of COVID19. Methods: We retrospectively analyzed the clinical characteristics, treatment, and disease outcomes of three patients with gynecological malignancies associated with COVID19 in Renmin Hospital of Wuhan University in January 2020, and proposed management strategies for patients with gynecological tumors under risk of COVID19. Results: Three patients were treated COVID19 based on the national diagnosis and treatment protocol as well as research progress. […] Meanwhile, these patients were appropriately adjusted the treatment plan in accordance with the clinical guidelines for gynecological tumors. […] Pneumonia was cured in 2 patients, and one patient died of COVID-19. Conclusions: Patients with gynecological malignant tumors are high-risk groups prone to COVID-19 infection, and gynecological oncologists need to carry out education, prevention, control and treatment according to specific conditions. […] While actively preventing and controlling COVID-19, the diagnosis and treatment of gynecological malignant tumors should be carried out in an orderly and safe manner. 目的: 在新型冠状病毒肺炎(COVID-19)暴发和传播期间,探讨妇科恶性肿瘤患者的管理策略。 2020-03-16
Clinical Features of 69 Cases with Coronavirus Disease 2019 in Wuhan, China. Most patients received antiviral therapy (66 [98.5%] of 67 patients) and antibiotic therapy (66 [98.5%] of 67 patients). […] Arbidol treatment showed tendency to improve the discharging rate and decrease the mortality rate. 2020-03-16
Emerging WuHan (COVID-19) coronavirus: glycan shield and structure prediction of spike glycoprotein and its interaction with human CD26. These findings accentuate the unique features of COVID-19 and assist in the development of new therapeutics. 2020-03-19
COVID-19 and Italy: what next? Intensive care units will then be at maximum capacity; up to 4000 hospital beds will be needed by mid-April, 2020. 2020-04-16
Teicoplanin: an alternative drug for the treatment of COVID-19? This activity is conserved against SARS-Cov-2, thus placing teicoplanin as a potential treatment for patients with this virus. 2020-04-02
Ginkgolic acid inhibits fusion of enveloped viruses. Coronavirus, EBOV, ZIKV, IAV and measles), and also topically for the successful treatment of active lesions (e.g. 2020-03-24
A 55-Day-Old Female Infant infected with COVID 19: presenting with pneumonia, liver injury, and heart damage. We report a 55-day-old case with COVID-19 confirmed in China and describe the identification, diagnosis, clinical course, and treatment of the patient, including the disease progression from day 7 to day 11 of illness. 2020-03-17
Clinical features of pediatric patients with COVID-19: a report of two family cluster cases. We should attach importance to early recognition, early diagnosis, and early treatment of infected children. 2020-03-17
Safety and efficacy of different anesthetic regimens for parturients with COVID-19 undergoing Cesarean delivery: a case series of 17 patients. Three of the parturients are still recovering from their Cesarean delivery and are receiving in-hospital treatment for COVID-19. 2020-04-03
Platelet-to-lymphocyte ratio is associated with prognosis in patients with coronavirus disease-19. In severe novel coronavirus pneumonia cases, the number of platelets, their dynamic changes during the treatment, platelet-to-lymphocyte ratio (PLR) were a concern. […] Demographic, clinical, blood routine results, other laboratory results, and treatment data were collected and analyzed. […] Univariate analysis showed that: age, platelet peaks, and PLR at peak platelet were the influencing factors in severe patients, multivariate analysis showed that the PLR value at peak platelet during treatment was an independent influencing factor in severe patients. […] The average hospitalization day of patients with platelet peaks during treatment was longer than those without platelet peaks (P < .05). […] The average age of patients with platelet peaks during treatment was older than those without platelet peaks (P < .05). […] The patients with significantly elevated platelets during treatment had longer average hospitalization days. […] And the higher PLR of patients during treatment had longer average hospitalization days. […] Single-center case series of the 30 hospitalized patients with confirmed COVID-19 in Huizhou Municipal Central Hospital, presumed that the number of platelets and their dynamic changes during the treatment may have a suggestion on the severity and prognosis of the disease. 2020-03-28
Successful recovery of COVID-19 pneumonia in a renal transplant recipient with long-term immunosuppression. Following a treatment regimen consisting of reduced immunosuppressant use and low dose methylprednisolone-based therapy, the COVID-19 pneumonia in this long-term immunosuppressive patient was successfully recovered. […] This effectively treated case has reference value for the future treatment of other transplant patients with COVID-19 pneumonia. 2020-04-01
Epidemiology, causes, clinical manifestation and diagnosis, prevention and control of coronavirus disease (COVID-19) during the early outbreak period: a scoping review. To date, no specific antiviral treatment has proven effective; hence, infected people primarily rely on symptomatic treatment and supportive care. 2020-03-19
[Challenges and countermeasures on Chinese malaria elimination programme during the coronavirus disease 2019 (COVID-19) outbreak]. If the diagnosis and treatment of malaria cases as well as the investigation and response of the epidemic foci are not carried out timely, it may endanger patients’lives and cause the possible of secondary transmission, which threatens the achievements of malaria elimination in China. […] Due to the extensive spread and high transmission ability of the COVID-19, there is a possibility of virus infections among malaria cases during the medical care-seeking behaviors and among healthcare professionals during clinical diagnosis and treatment, sample collection and testing and epidemiological surveys. 2020-03-19
[Thoughts and practice on the treatment of severe and critical new coronavirus pneumonia]. Close monitoring of oxygenation, reducing patients’ oxygen consumption, active psychological intervention, and rapidly dealing with severe hypoxemia events are the key factors for the successful treatment of NIV. […] In addition, active adjuvant therapy is also important, such as correcting coagulation dysfunction, providing proper nutritional support, accurate volume control, and safe individualized blood glucose monitoring and control. 2020-03-18
Rapidly increasing cumulative incidence of coronavirus disease (COVID-19) in the European Union/European Economic Area and the United Kingdom, 1 January to 15 March 2020. Based on the experience from Italy, countries, hospitals and intensive care units should increase their preparedness for a surge of patients with COVID-19 who will require healthcare, and in particular intensive care. 2020-04-02
Pregnancy and Perinatal Outcomes of Women With Coronavirus Disease (COVID-19) Pneumonia: A Preliminary Analysis. OBJECTIVE. The purpose of this study was to describe the clinical manifestations and CT features of coronavirus disease (COVID-19) pneumonia in 15 pregnant women and to provide some initial evidence that can be used for guiding treatment of pregnant women with COVID-19 pneumonia. MATERIALS AND METHODS. We reviewed the clinical data and CT examinations of 15 consecutive pregnant women with COVID-19 pneumonia in our hospital from January 20, 2020, to February 10, 2020. […] Symptoms and laboratory results were analyzed, treatment experiences were summarized, and clinical outcomes were tracked. RESULTS. Eleven patients had successful delivery (10 cesarean deliveries and one vaginal delivery) during the study period, and four patients were still pregnant (three in the second trimester and one in the third trimester) at the end of the study period. 2020-03-18
COVID-19, an emerging coronavirus infection: advances and prospects in designing and developing vaccines, immunotherapeutics, and therapeutics. However, to date, no licensed antiviral treatment or vaccine exists for MERS and SARS. […] This article highlights ongoing advances in designing vaccines and therapeutics to counter COVID-19 while also focusing on such experiences and advances as made with earlier SARS- and MERS-CoVs, which together could enable efforts to halt this emerging virus infection. 2020-04-01
A Trial of Lopinavir-Ritonavir in Adults Hospitalized with Severe Covid-19. No therapeutics have yet been proven effective for the treatment of severe illness caused by SARS-CoV-2. […] Treatment with lopinavir-ritonavir was not associated with a difference from standard care in the time to clinical improvement (hazard ratio for clinical improvement, 1.24; 95% confidence interval [CI], 0.90 to 1.72). […] Lopinavir-ritonavir treatment was stopped early in 13 patients (13.8%) because of adverse events. […] In hospitalized adult patients with severe Covid-19, no benefit was observed with lopinavir-ritonavir treatment beyond standard care. […] Future trials in patients with severe illness may help to confirm or exclude the possibility of a treatment benefit. 2020-04-12
Insight into COVID-2019 for pediatricians. From the perspective of clinical pediatricians as the first line fighting the epidemic, this paper will discuss the clinical characteristics, prevention and control measures, outcomes, diagnosis, and treatment of pediatric cases. 2020-04-16
CT image of novel coronavirus pneumonia: a case report. Knowledge of CT characteristics of COVID-19 pneumonia might be helpful to the early diagnosis and treatment of patients, and to control the spread of infection. 2020-03-19
SARS-CoV-2 and COVID-19: The most important research questions. Here we highlight nine most important research questions concerning virus transmission, asymptomatic and presymptomatic virus shedding, diagnosis, treatment, vaccine development, origin of virus and viral pathogenesis. 2020-03-22
Alert for non-respiratory symptoms of Coronavirus Disease 2019 (COVID-19) patients in epidemic period: A case report of familial cluster with three asymptomatic COVID-19 patients. Here we reported the screening, clinical feathers, and treatment process of a family cluster involving three COVID-19 patients. 2020-03-19
Evaluation of the Effectiveness of Surveillance and Containment Measures for the First 100 Patients with COVID-19 in Singapore - January 2-February 29, 2020. Singapore adopted a multipronged surveillance strategy that included applying the case definition at medical consults, tracing contacts of patients with laboratory-confirmed COVID-19, enhancing surveillance among different patient groups (all patients with pneumonia, hospitalized patients in intensive care units [ICUs] with possible infectious diseases, primary care patients with influenza-like illness, and deaths from possible infectious etiologies), and allowing clinician discretion (i.e., option to order a test based on clinical suspicion, even if the case definition was not met) to identify COVID-19 patients. 2020-03-20
COVID-19 - what should anaethesiologists and intensivists know about it? Severe forms of the infection, being an indication for treatment in the intensive care unit, comprise acute lung inflammation, ARDS, sepsis and septic shock. […] The article presents basic information about etiology, pathogenesis and diagnostics (with particular emphasis on the importance of tomocomputer imaging), clinical picture, treatment and prevention of the infection. […] Due to the fact that effective causal treatment is not yet available and the number of infections and deaths increases day by day, infection prevention and strict adherence to recommendations of infection control organizations remain the basis for fighting the virus. 2020-03-26
WHO International Health Regulations Emergency Committee for the COVID-19 outbreak. These measures for early detection and screening of cases should be followed by full efforts to produce research-based evidence by thoroughly analyzing epidemiological, clinical and immunological data, which will facilitate the development of vaccines and therapeutics for COVID-19. 2020-04-08
[Treatment strategies for colorectal cancer patients in tumor hospitals under the background of corona virus disease 2019]. By summarizing the research progress and guidelines in recent years in the fields of colorectal cancer disease screening, treatment strategies (including early colorectal cancer, locally advanced colorectal cancer, obstructive colorectal cancer, metastatic colorectal cancer and the treatment of patients after neoadjuvant therapy), the choice of medication and time limit for adjuvant therapy, the protective measures for patients undergoing emergency surgery, the re-examination of postoperative patients and the protection of medical staff, etc., authors improve treatment strategies in order to provide more choices for patients to obtain the best treatment under the severe epidemic situation of new coronavirus pneumonia. […] Meanwhile we hope that it can also provide more timely treatment modeling schemes for colleagues. 2020-03-23
[Standardized diagnosis and treatment of colorectal cancer during the outbreak of corona virus disease 2019 in Renji hospital]. Although colorectal surgery is not a front-line subject in the fight against the epidemic, but in this special situation, it is a difficult task to provide the highest quality medical services and ensure the orderly clinical work, on the premise of maximizing the protection for patients and their families, health of medical staff, and the safety of wards and hospitals, We summarize how to carry out the clinical practice of colorectal surgery under the situation of the prevention and control of the COVID-19 epidemiology, including the procedures of diagnose and treatment for emergency patients with colorectal tumor, and share the experiences of the diagnosis of colorectal tumor, the management of patients with colorectal cancer who are scheduled to be admitted for surgery, the protection of wards, the perioperative management. […] The main points are as follows: (1) Multidisciplinary team (MDT) must be run through the diagnosis and treatment of colorectal cancer. 2020-03-23
[Chemotherapy strategy for colorectal cancer under the outbreak of corona virus disease 2019]. The outbreak of corona virus disease 2019 (COVID-19) makes the medical treatment of colorectal cancers difficult. […] For metastatic colorectal cancer (CRC) patients, maintenance therapy is the optimal choice. […] Adjuvant chemotherapy should reduce the intensity of treatment and shorten the therapy time. 2020-03-23
CT manifestations of coronavirus disease-2019: A retrospective analysis of 73 cases by disease severity. We analyzed the initial and follow-up CT features of patients with disease severity, according to the Guidelines for the Diagnosis and Treatment of New Coronavirus Pneumonia. 2020-04-10
Clinical features of severe pediatric patients with coronavirus disease 2019 in Wuhan: a single center’s observational study. Treatment modalities were focused on symptomatic and respiratory support. […] Up to February 24, 2020, three patients remained under treatment in ICU, the other five recovered and were discharged home. 2020-03-20
First Pediatric Case of Coronavirus Disease 2019 in Korea. In this report, we present mild clinical course of her pneumonia that did not require antiviral treatment and serial viral test results from multiple specimens. 2020-03-23
How Should the Rehabilitation Community Prepare for 2019-nCoV? It is more infectious and fatal than seasonal influenza, and definitive treatment and a vaccine are months away. 2020-04-14
Prediction of the SARS-CoV-2 (2019-nCoV) 3C-like protease (3CL pro) structure: virtual screening reveals velpatasvir, ledipasvir, and other drug repurposing candidates. Among these, the antivirals ledipasvir or velpatasvir are particularly attractive as therapeutics to combat the new coronavirus with minimal side effects, commonly fatigue and headache. 2020-03-24
COVID-19 Infection: Implications for Perioperative and Critical Care Physicians. Here, the authors review COVID-19 pathogenesis, presentation, diagnosis, and potential therapeutics, with a focus on management of COVID-19-associated respiratory failure. […] The authors draw on literature from other viral epidemics, treatment of acute respiratory distress syndrome, and recent publications on COVID-19, as well as guidelines from major health organizations. 2020-04-16
Response of Chinese Anesthesiologists to the COVID-19 Outbreak. So far, actions have been taken including but not limited to nationwide actions and online education regarding special procedures of airway management, oxygen therapy, ventilation support, hemodynamic management, sedation, and analgesia. 2020-04-16
Intubation and Ventilation amid the COVID-19 Outbreak: Wuhan’s Experience. Timely, but not premature, intubation is crucial to counter a progressively enlarging oxygen debt despite high-flow oxygen therapy and bilevel positive airway pressure ventilation. 2020-04-16
PRESCIENT: platform for the rapid evaluation of antibody success using integrated microfluidics enabled technology. Identifying antibodies (Abs) that neutralize infectious agents is the first step for developing therapeutics, vaccines, and diagnostic tools for these infectious agents. 2020-03-20
COVID-19: a recommendation to examine the effect of hydroxychloroquine in preventing infection and progression. There is an urgent need to identify safe and effective drugs for treatment. 2020-03-20
Hypothesis for potential pathogenesis of SARS-CoV-2 infection-a review of immune changes in patients with viral pneumonia. Combined with the published literature, the potential pathogenesis of COVID-19 is inferred, and the treatment recommendations for giving high-doses intravenous immunoglobulin and low-molecular-weight heparin anticoagulant therapy to severe type patients are proposed. 2020-04-07
The clinical characteristics of pneumonia patients coinfected with 2019 novel coronavirus and influenza virus in Wuhan, China. All patients were given antiviral therapy (including oseltamivir), oxygen inhalation, and antibiotics. […] One of the five patients had transient hemostatic medication for hemoptysis. 2020-03-31
Managing Cancer Care During the COVID-19 Pandemic: Agility and Collaboration Toward a Common Goal. This Special Feature highlights the unique circumstances and challenges of cancer treatment amidst this global pandemic, and the importance of organizational structure, preparation, agility, and a shared vision for continuing to provide cancer treatment to patients in the face of uncertainty and rapid change. 2020-04-10
Practical recommendations for the perioperative management of the patient with suspection or serious infection by coronavirus SARS-CoV. There is not specific treatment for SARS-CoV-2, which is why the fundamental aspects are to establish adequate prevention measures and support treatment and management of complications. 2020-04-01
Clinical features and treatment of COVID-19 patients in northeast Chongqing. Epidemiological, clinical features, laboratory findings, radiological characteristics, treatment, and clinical outcomes of 135 patients in northeast Chongqing were collected and analyzed in this study. […] All patients received antiviral therapy (135 [100%]) (Kaletra and interferon were both used), antibacterial therapy (59 [43.7%]), and corticosteroids (36 [26.7%]). […] Kaletra and TCM played an important role in the treatment of the viral pneumonia. […] Further studies are required to explore the role of Kaletra and TCM in the treatment of COVID-19. 2020-04-02
A review of the 2019 Novel Coronavirus (COVID-19) based on current evidence. Based on the current published evidence, we systematically summarizes the epidemiology, clinical characteristics, diagnosis, treatment and prevention of knowledge surrounding COVID-19. 2020-04-16
Lopinavir/ritonavir combination therapy amongst symptomatic coronavirus disease 2019 patients in India: Protocol for restricted public health emergency use. Hospitalized adult patients with laboratory-confirmed SARS-CoV-2 infection with any one of the following criteria will be eligible to receive lopinavir/ritonavir for 14 days after obtaining written informed consent: (i) respiratory distress with respiratory rate ≥22/min or SpO2 of <94 per cent; (ii) lung parenchymal infiltrates on chest X-ray; (iii) hypotension defined as systolic blood pressure <90 mmHg or need for vasopressor/inotropic medication; (iv) new-onset organ dysfunction; and (v) high-risk groups - age >60 yr, diabetes mellitus, renal failure, chronic lung disease and immunocompromised persons. […] Treatment outcomes amongst initial cases would be useful in providing guidance about the clinical management of patients with COVID-19. 2020-03-23
Systematic review of COVID-19 in children shows milder cases and a better prognosis than adults. Suggested treatment included providing oxygen, inhalations, nutritional support and maintaining fluids and electrolyte balances. 2020-04-14
Factors Associated With Mental Health Outcomes Among Health Care Workers Exposed to Coronavirus Disease 2019. Frontline health care workers engaged in direct diagnosis, treatment, and care of patients with COVID-19 were associated with a higher risk of symptoms of depression (OR, 1.52; 95% CI, 1.11-2.09; P = .01), anxiety (OR, 1.57; 95% CI, 1.22-2.02; P < .001), insomnia (OR, 2.97; 95% CI, 1.92-4.60; P < .001), and distress (OR, 1.60; 95% CI, 1.25-2.04; P < .001). […] In this survey of heath care workers in hospitals equipped with fever clinics or wards for patients with COVID-19 in Wuhan and other regions in China, participants reported experiencing psychological burden, especially nurses, women, those in Wuhan, and frontline health care workers directly engaged in the diagnosis, treatment, and care for patients with COVID-19. 2020-04-01
Characterization of the receptor-binding domain (RBD) of 2019 novel coronavirus: implication for development of RBD protein as a viral attachment inhibitor and vaccine. The outbreak of Coronavirus Disease 2019 (COVID-19) has posed a serious threat to global public health, calling for the development of safe and effective prophylactics and therapeutics against infection of its causative agent, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), also known as 2019 novel coronavirus (2019-nCoV). 2020-03-26
Planning and provision of ECMO services for severe ARDS during the COVID-19 pandemic and other outbreaks of emerging infectious diseases. Available evidence from similar patient populations suggests that carefully selected patients with severe ARDS who do not benefit from conventional treatment might be successfully supported with venovenous ECMO. 2020-04-01
The Impact of COVID-19 Epidemic Declaration on Psychological Consequences: A Study on Active Weibo Users. It may provide references for policy makers to plan and fight against COVID-19 effectively by improving stability of popular feelings and urgently prepare clinical practitioners to deliver corresponding therapy foundations for the risk groups and affected people. 2020-04-01
[Standardized management guideline for pediatric wards of hematology and oncology during the epidemic of coronavirus disease 2019]. With the spread of coronavirus disease 2019 (COVID-19) and growing knowledge of its diagnosis and treatment, it has been clear that children are also susceptible to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). 2020-03-26
Consideration of the respiratory support strategy of severe acute respiratory failure caused by SARS-CoV-2 infection in children. At present there is limited clinical information of the SARS-CoV-2 and there is no specific treatment recommended, although technical guidances and suggestions have been developed and will continue to be updated as additional information becomes available. […] Preventive treatment has an important role to control and avoid the spread of severe respiratory disease, but often is difficult to obtain and sometimes cannot be effective to reduce the risk of deterioration of the underlining lung pathology. […] In order to define an effective and safe treatment for SARS-CoV-2-associated disease, we provide considerations on the actual treatments, on how to avoid complications and the undesirable side effects related to them and to select and apply earlier the most appropriate treatment. […] The final outcome is strictly connected with the ability to apply an appropriate treatment early and to reduce all the complications that can arise during the intensive care admission. 2020-03-26
[SARS-CoV-2 infection with gastrointestinal symptoms as the first manifestation in a neonate]. After two weeks of treatment, the patient recovered gradually and was discharged. 2020-03-26
[Twin girls infected with SARS-CoV-2]. This article reports the diagnosis and treatment of twin girls who were diagnosed with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in Hunan Province, China. […] Both recovered after symptomatic treatment. 2020-03-26
[Emergency plan for inter-hospital transfer of newborns with SARS-CoV-2 infection]. Newborns with suspected or confirmed COVID-19 should be transferred to designated hospitals for isolation treatment. 2020-03-26
TH17 responses in cytokine storm of COVID-19: An emerging target of JAK2 inhibitor Fedratinib. Development of effective prevention and treatment is an urgent need. 2020-04-16
COVID-19 infection and rheumatoid arthritis: Faraway, so close! Given the lack of specific anti-viral therapies, the current management of severe acute respiratory syndrome coronaviruses (SARS-CoV-2) is mainly supportive, even though several compounds are now under investigation for the treatment of this life-threatening disease. […] COVID-19 pandemic is certainly conditioning the treatment strategy of a complex disorder as rheumatoid arthritis (RA), whose infectious risk is increased compared to the general population because of an overall impairment of immune system typical of autoimmune diseases combined with the iatrogenic effect generated by corticosteroids and immunosuppressive drugs. […] However, the increasing knowledge about the pathophysiology of SARS-CoV-2 infection is leading to consider some anti-rheumatic drugs as potential treatment options for the management of COVID-19. 2020-04-01
Hydroxychloroquine and azithromycin as a treatment of COVID-19: results of an open-label non-randomized clinical trial. Depending on their clinical presentation, azithromycin was added to the treatment. […] Despite its small sample size our survey shows that hydroxychloroquine treatment is significantly associated with viral load reduction/disappearance in COVID-19 patients and its effect is reinforced by azithromycin. 2020-04-01
Lianhuaqingwen exerts anti-viral and anti-inflammatory activity against novel coronavirus (SARS-CoV-2). Furthermore, LH treatment resulted in abnormal particle morphology of virion in cells. 2020-04-01
Updated approaches against SARS-CoV-2. Scientists are racing towards the development of treatment for COVID-19. 2020-03-24
Clinical Characteristics of Children with Coronavirus Disease 2019 in Hubei, China. However, children less than 3 years old accounted for majority cases and critical cases lied in this age group, which demanded extra attentions during home caring and hospitalization treatment. 2020-03-24
Establishment and validation of a pseudovirus neutralization assay for SARS-CoV-2. Due to its high pathogenicity and infectivity and the lack of effective vaccines and therapeutics, live SARS-CoV-2 has to be handled under biosafety level 3 conditions, which has hindered the development of vaccines and therapeutics. […] When tested against the SARS-CoV-2 pseudovirus, SARS-CoV-2 convalescent patient sera showed high neutralizing potency, which underscore its potential as therapeutics. […] Taken together, we established a robust pseudovirus-based neutralization assay for SARS-CoV-2 and are glad to share pseudoviruses and related protocols with the developers of vaccines or therapeutics to fight against this lethal virus. 2020-03-26
[CT imaging features of patients with different clinical types of coronavirus disease 2019 (COVID-19)]. A total of 67 patients diagnosed as COVID-19 by nucleic acid testing were included and divided into 4 groups according to the clinical staging based on Diagnosis and treatment of novel coronavirus pneumonia (Trial version 6). 2020-03-26
COVID-19: decision making and palliative care. Due to the current development around the COVID-19 pandemic, palliative ch has created a Task Force to provide recommendations for health professionals on the treatment of palliative care patients in the various settings ‒ inpatient and outpatient. 2020-04-02
Clinical observation and management of COVID-19 patients. Furthermore, he observes the significant abnormality of coagulation function and proposes that the early intravenous immunoglobulin and low molecular weight heparin anticoagulation therapy are very important. […] For severe or critically ill patients, in addition to the respiratory supportive treatment, timely multiorgan evaluation and treatment is very crucial. 2020-04-07
Renin-Angiotensin System Blockers and the COVID-19 Pandemic: At Present There Is No Evidence to Abandon Renin-Angiotensin System Blockers. Because the ACE2 (angiotensin-converting enzyme 2) protein is the receptor that facilitates coronavirus entry into cells, the notion has been popularized that treatment with renin-angiotensin system blockers might increase the risk of developing a severe and fatal severe acute respiratory syndrome coronavirus-2 infection. […] In summary, based on the currently available evidence, treatment with renin-angiotensin system blockers should not be discontinued because of concerns with coronavirus infection. 2020-03-26
Clinical characteristics of fatal and recovered cases of coronavirus disease 2019 (COVID-19) in Wuhan, China: a retrospective study. C-reactive protein (CRP) levels were also significantly higher in the death group on admission (109.25 [35.00, 170.28] mg/L vs.3.22 [1.04, 21.80] mg/L, Z = 10.206, P < 0.001) showed no significant improvement after treatment (109.25 [35.0, 170.28] mg/L vs. 2020-03-26
Unrevealing sequence and structural features of novel coronavirus using in silico approaches: The main protease as molecular target. Altogether, the results presented in this work contribute to gain a deep understanding of the molecular pharmacology of SARS-CoV-2 treatment and validate the use of protease inhibitors against SARS-CoV-2. 2020-03-28
Association of Cardiac Injury With Mortality in Hospitalized Patients With COVID-19 in Wuhan, China. Clinical laboratory, radiological, and treatment data were collected and analyzed. 2020-03-28
Analysis of Epidemiological and Clinical features in older patients with Corona Virus Disease 2019 (COVID-19) out of Wuhan. Epidemiological, clinical and treatment data were analyzed between those older (≥60y) and younger (<60y) patients. 2020-03-26
Coronavirus disease 2019: initial chest CT findings. We retrospectively reviewed the initial chest CT data of 62 confirmed coronavirus disease 2019 patients (34 men, 28 women; age range 20-91 years old) who did not receive any antiviral treatment between January 21 and February 4, 2020, in Chongqing, China. 2020-03-30
Optimizing COVID-19 candidate therapeutics: Thinking Without Borders. This commentary seeks to share some key insights relevant to optimizing COVID-19 candidate therapeutics that were learned from attempts to optimize anti-infective posology in settings where quality and timely availability of data is challenging, with particular focus on influenza, including experiences from H5N1 and pH1N1 outbreaks. 2020-03-26
Cancer Care Delivery Challenges Amidst Coronavirus Disease - 19 (COVID-19) Outbreak: Specific Precautions for Cancer Patients and Cancer Care Providers to Prevent Spread. Cancer patients are more susceptible to coronavirus infection than individuals without cancer as they are in an immunosuppressive state because of the malignancy and anticancer treatment. 2020-04-02
Pharmacologic Treatments and Supportive Care for Middle East Respiratory Syndrome. Available animal and cell line models have suggested that specific therapeutics might be effective in treating Middle East respiratory syndrome (MERS). […] We conducted a systematic review of evidence for treatment with pharmacologic and supportive therapies. […] We developed a protocol and searched 5 databases for studies describing treatment of MERS and deaths in MERS patients. […] One study, at moderate RoB, showed reduced mortality rates in severe MERS patients with extracorporeal membrane oxygenation; no other studies showed a significant lifesaving benefit to any treatment. […] Clinical trials are needed to guide treatment decisions. 2020-03-27
Italy in a Time of Emergency and Scarce Resources: The Need for Embedding Ethical Reflection in Social and Clinical Settings. The COVID-19 virus is severely testing the Italian healthcare system, as the requests for intensive treatment are greater than the real capacity of the system to receive patients. 2020-04-02
Expanded Umbilical Cord Mesenchymal Stem Cells (UC-MSCs) as a Therapeutic Strategy in Managing Critically Ill COVID-19 Patients: The Case for Compassionate Use. The World Health Organization (WHO) and multiple agencies led by the CDC in the United States have attempted to organize intensive outbreak investigation programs utilizing appropriate preventive measures, evaluation, and treatment. […] These include vaccines, medications Remdesivir and hydroxychloroquine and potentially combination therapy. […] Thus, at this point, the avoidance of the cytokine storm may be the key for the treatment of HCOV-19 infected patients.In China, where there was limited availability of effective modalities to manage COVID-19 several patients were treated with expanded UC-MSCs. […] In this manuscript, we describe the urgent need for various solutions, pathogenesis of coronavirus and the clinical evidence for treatment of COVID-19 with stem cells. 2020-04-01
Simulation of the clinical and pathological manifestations of Coronavirus Disease 2019 (COVID-19) in golden Syrian hamster model: implications for disease pathogenesis and transmissibility. Besides satisfying the Koch’s postulates, this readily available hamster model is an important tool for studying transmission, pathogenesis, treatment, and vaccination against SARS-CoV-2. 2020-03-27
Structural and biochemical characterization of SADS-CoV papain-like protease 2. These results provide a foundation for understanding the molecular basis of coronaviral PLPs’ catalytic mechanism and for the screening and design of therapeutics to combat infection by SADS coronavirus. 2020-04-06
[Prevention and control of SARS-CoV-2 (Covid-19) coronavirus infection in hemodialysis units]. Additionally, they constitute a closed conglomerate since they come to treatment regularly, spending hours in the treatment places, exposed to a possible acquisition of the infection. […] Finally, going to their treatment regularly prevents them from remaining in home isolation and with potential exposure. 2020-03-27
Managing Oncology Services During a Major Coronavirus Outbreak: Lessons From the Saudi Arabia Experience. Outbreaks of infectious etiology, particularly those caused by a novel virus that has no known treatment or vaccine, may result in the interruption of medical care provided to patients with cancer and put them at risk for undertreatment in addition to the risk of being exposed to infection, a life-threatening event among patients with cancer. […] This article describes the approach used to manage patients with cancer during a large-scale Middle East respiratory syndrome-coronavirus hospital outbreak in Saudi Arabia to ensure continuity of care and minimize harm from treatment interruption or acquiring infection. 2020-04-08
Coronavirus Disease 2019 (COVID-19) Pandemic and Pregnancy. We discuss the latest options in antiviral therapy and vaccine development, including the novel use of chloroquine in the management of COVID-19. 2020-03-28
SARS-CoV-2: a storm is raging. Overall, this study characterized the cytokine storm in severe COVID-19 and provides insights into immune therapeutics and vaccine design. 2020-04-13
Synthesis and Biological Evaluation of Novel (thio)semicarbazone-Based Benzimidazoles as Antiviral Agents against Human Respiratory Viruses. The herein-investigated benzimidazole-based derivatives may represent valuable hit compounds, deserving subsequent structural improvements towards more efficient antiviral agents for the treatment of pathologies caused by these human respiratory viruses. 2020-03-30
Could Intravenous Immunoglobulin Collected from Recovered Coronavirus Patients Protect against COVID-19 and Strengthen the Immune System of New Patients? At the present, there is no single specific vaccine or efficient antiviral therapy against COVID-19. […] Recently, we showed that intravenous immunoglobulin (IVIg) treatment reduces inflammation of intestinal epithelial cells and eliminates overgrowth of the opportunistic human fungal pathogen Candida albicans in the murine gut. […] Different procedures may be used to remove or inactivate any possible pathogens from the plasma of recovered coronavirus patient derived immune IgG, including solvent/detergent, 60 °C heat-treatment, and nanofiltration. […] Overall, immunotherapy with immune IgG antibodies combined with antiviral drugs may be an alternative treatment against COVID-19 until stronger options such as vaccines are available. 2020-04-07
Cardiovascular Implications of Fatal Outcomes of Patients With Coronavirus Disease 2019 (COVID-19). During hospitalization, patients with elevated TnT levels had more frequent malignant arrhythmias, and the use of glucocorticoid therapy (37 [71.2%] vs 69 [51.1%]) and mechanical ventilation (41 [59.6%] vs 14 [10.4%]) were higher compared with patients with normal TnT levels. […] Aggressive treatment may be considered for patients at high risk of myocardial injury. 2020-03-31
Cardiac Involvement in a Patient With Coronavirus Disease 2019 (COVID-19). She was treated with dobutamine, antiviral drugs (lopinavir/ritonavir), steroids, chloroquine, and medical treatment for heart failure, with progressive clinical and instrumental stabilization. 2020-03-28
Treatment of 5 Critically Ill Patients With COVID-19 With Convalescent Plasma. To determine whether convalescent plasma transfusion may be beneficial in the treatment of critically ill patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. […] Case series of 5 critically ill patients with laboratory-confirmed COVID-19 and acute respiratory distress syndrome (ARDS) who met the following criteria: severe pneumonia with rapid progression and continuously high viral load despite antiviral treatment; Pao2/Fio2 <300; and mechanical ventilation. […] All 5 patients (age range, 36-65 years; 2 women) were receiving mechanical ventilation at the time of treatment and all had received antiviral agents and methylprednisolone. […] ARDS resolved in 4 patients at 12 days after transfusion, and 3 patients were weaned from mechanical ventilation within 2 weeks of treatment. […] The limited sample size and study design preclude a definitive statement about the potential effectiveness of this treatment, and these observations require evaluation in clinical trials. 2020-03-31
Experience of Clinical Management for Pregnant Women and Newborns with Novel Coronavirus Pneumonia in Tongji Hospital, China. Based on the New Diagnosis and Treatment Scheme for Novel Coronavirus Infected Pneumonia (Trial Edition 5), combined with our current clinical treatment experience, we recently proposed a revision of the first edition of “Guidance for maternal and fetal management during pneumonia epidemics of novel coronavirus infection in the Wuhan Tongji Hospital”. […] This article focused on the issues of greatest concern of pregnant women including severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection diagnostic criteria, inspection precautions, drug treatment options, indications and methods of termination of pregnancy, postpartum fever, breastfeeding considerations, mode of mother-to-child transmission, neonatal isolation and advice on neonatal nursing, to provide valuable experience for better management of SARS-CoV-2 infection in pregnant women and newborns. 2020-03-28
Development Path and Urgency of further Strengthening Construction of Public Hospitals Based on Novel Coronavirus Pneumonia Treatment. Based on the treatment of severe patients in Wuhan, combined with the treatment practice in Tongji Hospital affiliated to Tongji Medical College, Huazhong University of Science and Technology, this paper puts forward the urgency of further strengthening the construction of public hospitals, discusses the feasible path for promoting the development of public hospitals, so as to meet the growing medical needs of the people, improve the ability to respond to major public health emergencies, and effectively guarantee the safety of people’s lives and the promotion of a healthy China construction. 2020-03-28
[Expert consensus on the management strategy of patients with hereditary ataxia during prevention and control of novel coronavirus pneumonia epidemic]. In view of the seriousness of the COVID-19 epidemic, a series of prevention and control measures adopted by the government have restricted the follow-up, diagnosis and treatment of patients by the hospitals, which has a great impact on their mental and physical health. 2020-04-02
Controversial treatments: An updated understanding of the coronavirus disease 2019. In the absence of specific treatment for this virus, there is an urgent need to learn from the experience and lessons in China. […] To help understand the advantages and limitations of differential treatments, we provide a timely review and discuss the complications and corresponding major treatments, especially controversial ones such as antiviral therapy (remdesivir, ribavirin, and chloroquine), glucocorticoid therapy, extracorporeal support including an artificial liver system, and extracorporeal membrane oxygenation based on available evidence. […] As a result, we suggest that antiviral therapy and organ function support are vital to reduce mortality for mild patients and critical patients, respectively. 2020-04-10
Stability issues of RT-PCR testing of SARS-CoV-2 for hospitalized patients clinically diagnosed with COVID-19. We also found that the RT-PCR results from several tests at different points were variable from the same patients during the course of diagnosis and treatment of these patients. […] Our results indicate that in addition to the emphasis on RT-PCR testing, clinical indicators such as computed tomography images should also be used not only for diagnosis and treatment but also for isolation, recovery/discharge, and transferring for hospitalized patients clinically diagnosed with COVID-19 during the current epidemic. 2020-04-05
Safe Delivery for COVID-19 Infected Pregnancies. Efficient obstetric treatment is required, and is key to optimizing the prognosis for both mother and child. 2020-03-28
Early antiviral treatment contributes to alleviate the severity and improve the prognosis of patients with novel coronavirus disease (COVID-19). Patients in the mild group experienced earlier initiation of antiviral treatment (1.19 ± 0.45 vs 2.65 ± 1.06 days in the severe group, P < 0.001). […] It is recommended that timely antiviral treatment should be initiated to slow the disease progression and improve the prognosis. 2020-03-28
Anticoagulant treatment is associated with decreased mortality in severe coronavirus disease 2019 patients with coagulopathy. Anticoagulant therapy mainly with LMWH appears to be associated with better prognosis in severe COVID-19 patients meeting SIC criteria or with markedly elevated D-dimer. 2020-03-28
[Epidemiology, Treatment, and Epidemic Prevention and Control of the Coronavirus Disease 2019: a Review]. This review summarizes the ongoing researches regarding etiology, epidemiology, transmission dynamics, treatment, and prevention and control strategies of the coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), with comparison to severe acute respiratory syndrome coronavirus (SARS-CoV), Middle East respiratory syndrome coronavirus (MERS-CoV) and pandemic H1N1 virus. […] Meanwhile, rapid detection kit for serological monitoring of the virus in general population is expected so as to achieve early detection, early diagnosis, early isolation and early treatment. 2020-04-02
[Biological Product Development Strategies for Prevention and Treatment of Coronavirus Disease 2019]. As biological products have broadly applied in the prevention and treatment of severe epidemic diseases, they are promising in blocking novel coronavirus infection. […] According to the research advances of severe acute respiratory syndrome (SARS) and Middle East respiratory syndrome (MERS), we reviewed the potential application of biological products such as interferon, convalescent plasma, intestinal micro-ecological regulators, vaccines and therapeutic antibodies, etc. , on prevention and treatment of COVID-19. 2020-04-02
[The Management of Blood Glucose Should be Emphasized in the Treatment of COVID-19]. Based on the higher mortality and the higher proportion of critically ill adults in coronavirus disease 2019 (COVID-19) patients with diabetes, good inpatient glycemic control is particularly important in the comprehensive treatment of COVID-19. […] Individualized blood glucose target goals and treatment strategies should be made according to specific circumstances of COVID-19 inpatients with diabetes. […] For mild patients, a strict glycemic control target (fasting plasma glucose (FPG) 4.4-6.1 mmol/L, 2-hour postprandial plasma glucose (2 h PG) 6.1-7.8 mmol/L) are recommended; a target for the glycemic control of common type patients (FPG 6.1-7.8 mmol/L, 2 h PG 7.8-10.0 mmol/L) and subcutaneous insulin deliver therapy are recommended; a target nonfasting blood glucose range of 10.0 mmol or less per liter for severe-type COVID-19 patients, a relatively Less stringent blood glucose control target (FPG 7.8-10.0 mmol/L, 2 h PG 7.8-13.9 mmol/L) for critically ill patients and intravenous insulin infusion therapy are recommended. […] Due to the rapid changes in the condition of some patients, the risk of diabetic ketoacidosis (DKA) or hyperglycemic hyperosmolar status (HHS) maybe occur during the treatment. 2020-04-02
[Clinical and coagulation characteristics of 7 patients with critical COVID-2019 pneumonia and acro-ischemia]. D-dimer and FDP levels increased progressively when COVID-2019 exacerbated, and 4 patients were diagnosed with definite disseminated intravascular coagulation (DIC). 6 patients received low molecular weight heparin (LMWH) treatment, after which their D-dimer and FDP decreased, but there was no significant improvement in clinical symptoms. 5 patients died finally and the median time from acro-ischemia to death was 12 days. Conclusions: The existence of hypercoagulation status in critical COVID-2019 patients should be monitored closely, and anticoagulation therapy can be considered in selected patients. […] More clinical data is needed to investigate the role of anticoagulation in COVID-2019 treatment. 目的: 总结合并肢端缺血的新型冠状病毒肺炎(COVID-19)患者的临床和凝血参数特征。 2020-03-29
Quantitative Detection and Viral Load Analysis of SARS-CoV-2 in Infected Patients. The widely used reverse transcription PCR (RT-PCR) method has limitations for clinical diagnosis and treatment. 2020-03-29
The Italian coronavirus disease 2019 outbreak: recommendations from clinical practice. In particular, we describe key elements of clinical management, including: safe oxygen therapy; airway management; personal protective equipment; and non-technical aspects of caring for patients diagnosed with coronavirus disease 2019. 2020-04-01
Organ-protective effect of angiotensin-converting enzyme 2 and its effect on the prognosis of COVID-19. Because of these protective effects of ACE2 on chronic underlying diseases and ARDS, the development of spike protein-based vaccine and drugs enhancing ACE2 activity may become one of the most promising approaches for the treatment of COVID-19 in the future. 2020-04-05
Clinical analysis of pregnant women with 2019 novel coronavirus pneumonia. The aim is to evaluate pregnant women infected with coronavirus disease 2019 (COVID-19) and provide help for clinical prevention and treatment. 2020-04-10
[Management of a colon cancer patient infected with corona virus disease 2019]. To explore the feasibility of surgical treatment for cancer patients complicated with corona virus disease 2019 (COVID-19). […] The inflammation indicators and fever of this patient were effectively controlled and the lung lesions remained stable after active anti-viral treatment, then the radical colorectomy was performed after the viral negative conversion for twice. 2020-04-01
The use of anti-inflammatory drugs in the treatment of people with severe coronavirus disease 2019 (COVID-19): The Perspectives of clinical immunologists from China. Here, from the perspective of clinical immunologists, we will discuss the clinical and immunological characteristics of severe patients, and summarize the current evidence and share our experience in anti-inflammation treatment, including glucocorticoids, IL-6 antagonist, JAK inhibitors and choloroquine/hydrocholoroquine, of patients with severe COVID-19 that may have an impaired immune system. 2020-04-16
COVID-19 Infection in a Patient with End-Stage Kidney Disease. COVID-19 patients with ESKD need isolation dialysis, but most of them cannot be handled in time due to limited continuous renal replacement therapy (CRRT) machines. 2020-03-30
Advice on Standardized Diagnosis and Treatment for Spinal Diseases during the Coronavirus Disease 2019 Pandemic. Practical work experience in our spinal outpatient and emergency department during the COVID-19 pandemic is summarized in this article, with combined evidence-based medical evidence to explore a standardized process of diagnosis and treatment for spinal diseases. […] Spine surgeons should collaborate with infection control specialists to avoid cross-infection in hospitals and optimize treatment. 2020-04-07
Surviving Sepsis Campaign: guidelines on the management of critically ill adults with Coronavirus Disease 2019 (COVID-19). The topics were: (1) infection control, (2) laboratory diagnosis and specimens, (3) hemodynamic support, (4) ventilatory support, and (5) COVID-19 therapy. 2020-04-02
Detectable SARS-CoV-2 viral RNA in feces of three children during recovery period of COVID-19 pneumonia. All of these three cases experienced mild illness and recovered soon after the treatment, with the nucleic acid of throat swab turning negative within 14, 11, and 7 days after diagnosis, respectively. 2020-04-15
European Task Force on Atopic Dermatitis (ETFAD) statement on severe acute respiratory syndrome coronavirus 2 (SARS-Cov-2)-infection and atopic dermatitis. This also applies to AD patients on systemic immune-modulating treatment. […] In these days of uncertainty, reallocation of medical resources, curfew, hoarding, and shutdown of normal social life, patients, caregivers and doctors ask questions regarding the continuation of systemic immune-modulating treatment of AD patients. 2020-03-30
Sixty-eight consecutive patients assessed for COVID-19 infection: Experience from a UK Regional infectious diseases Unit. We compared clinical features between patients not requiring admission for clinical reasons or antimicrobials with those assessed as needing either admission or antimicrobial treatment. 2020-04-08
Timely Diagnosis and Treatment Shortens the Time to Resolution of Coronavirus Disease (COVID-19) Pneumonia and Lowers the Highest and Last CT Scores From Sequential Chest CT. OBJECTIVE. This study aims to assess correlations of the time from symptom onset to diagnosis and treatment with the time to disease resolution and CT scores as based on findings from sequential chest CT examinations. MATERIALS AND METHODS. Thirty patients with coronavirus disease (COVID-19) confirmed by reverse transcription-polymerase chain reaction analysis underwent chest CT examinations. […] The time from symptom onset to diagnosis and treatment was recorded for each patient, and on the basis of this information, patients with COVID-19 were divided into group 1 (patients for whom this interval was ≤ 3 days) and group 2 (those for whom this interval was > 3 days). […] The CT scores for each group were fitted using a Lorentzian line-shape curve to show the variation tendency during treatment. […] The differences in age, sex, and last CT scores determined before discharge between the two groups were analyzed, and correlations of the time from symptom onset to diagnosis and treatment with the time to disease resolution as well as with the highest CT score also underwent statistical analysis. RESULTS. A total of 25 subjects were enrolled in the study. […] The time from symptom onset to diagnosis and treatment had a positive correlation with the time to disease resolution (r = 0.93; p = 0.000) as well as with the highest CT score (r = 0.83; p = 0.006). CONCLUSION. Timely diagnosis and treatment are key to providing a better prognosis for patients with COVID-19. 2020-03-31
[Quick community survey on the impact of COVID-19 outbreak for the healthcare of people living with HIV]. Objective: To collect the current status and healthcare needs of people living with HIV (PLHIV) in China during the COVID-19 outbreak to inform quick response from government and communities. Methods: During February 5(th) to 10(th) , 2020, a national anonymous survey was conducted using an online questionnaire among PLHIV at least 18 years of age and had started antiretroviral treatment (ART) to collect the information on COVID-19 prevention, HIV-related health services and the needs on psychosocial support. 2020-03-31
Clinical characteristics of COVID-19-infected cancer patients: A retrospective case study in three hospitals within Wuhan, China. If the last anti-tumour treatment was within 14 days, it significantly increased the risk of developing severe events (HR=4.079, 95%CI 1.086-15.322, P=0.037). 2020-03-31
Surviving Sepsis Campaign: Guidelines on the Management of Critically Ill Adults with Coronavirus Disease 2019 (COVID-19). The topics were: 1) infection control, 2) laboratory diagnosis and specimens, 3) hemodynamic support, 4) ventilatory support, and 5) COVID-19 therapy. 2020-03-31
COVID-19: The outbreak caused by a new coronavirus. Thanks to the collaboration of experts worldwide, more information about this virus and its infection is reported each day, which allows modifying the recommendations for its prevention and treatment, without forgetting that the ultimate goal is to control this epidemic. 2020-04-03
Evaluation of SARS-CoV-2 RNA shedding in clinical specimens and clinical characteristics of 10 patients with COVID-19 in Macau. Four patients required oxygen therapy but none of them needed machinal ventilation. 2020-04-03
Traditional Chinese Medicine in the Treatment of Patients Infected with 2019-New Coronavirus (SARS-CoV-2): A Review and Perspective. No specific anti-virus drugs or vaccines are available for the treatment of this sudden and lethal disease. […] The supportive care and non-specific treatment to ameliorate the symptoms of the patient are the only options currently. […] At the top of these conventional therapies, greater than 85% of SARS-CoV-2 infected patients in China are receiving Traditional Chinese Medicine (TCM) treatment. […] In this article, relevant published literatures are thoroughly reviewed and current applications of TCM in the treatment of COVID-19 patients are analyzed. […] Due to the homology in epidemiology, genomics, and pathogenesis of the SARS-CoV-2 and SARS-CoV, and the widely use of TCM in the treatment of SARS-CoV, the clinical evidence showing the beneficial effect of TCM in the treatment of patients with SARS coronaviral infections are discussed. 2020-04-03
Perspectives on therapeutic neutralizing antibodies against the Novel Coronavirus SARS-CoV-2. Therapeutic neutralizing antibodies (NAbs) against SARS-CoV-2 will be greatly important therapeutic agents for the treatment of coronavirus disease 2019 (COVID-19). 2020-04-03
Targeting the Endocytic Pathway and Autophagy Process as a Novel Therapeutic Strategy in COVID-19. Such knowledge will provide important clues for control of the ongoing epidemic of SARS-CoV-2 infection and treatment of COVID-19. 2020-04-03
COVID-19: what has been learned and to be learned about the novel coronavirus disease. We will cover the basics about the epidemiology, etiology, virology, diagnosis, treatment, prognosis, and prevention of the disease. 2020-04-03
Acetazolamide, Nifedipine and Phosphodiesterase Inhibitors: Rationale for Their Utilization as Adjunctive Countermeasures in the Treatment of Coronavirus Disease 2019 (COVID-19). Following this potential treatment options emerge. […] Other therapeutics to consider that are also directed towards decreased pulmonary pressure include Nifedipine and Phosphodiesterase inhibitors. […] The utilization of medications found to be effective in HAPE, for the treatment of COVID-19, is proposed. 2020-04-02
The ACE2 expression in human heart indicates new potential mechanism of heart injury among patients infected with SARS-CoV-2. The finding of this study explains the high rate of severe cases among COVID-19 patients with basic cardiovascular disease; and these results also perhaps provide important reference to clinical treatment of cardiac injury among severe patients infected by SARS-CoV-2. 2020-03-31
Characteristics of peripheral lymphocyte subset alteration in COVID-19 pneumonia. The levels of peripheral lymphocyte subsets were measured by flow cytometry in 60 hospitalized COVID-19 patients before and after treatment, and their association with clinical characteristics and treatment efficacy was analyzed. […] After treatment, 37 patients (67%) reached clinical response, with an increase of CD8+ T cells and B cells. […] In multivariate analysis, post-treatment decrease of CD8+ T cells and B cells and increase of CD4+/CD8+ ratio were indicated as independent predictors for poor efficacy. […] Peripheral lymphocyte subset alteration was associated with the clinical characteristics and treatment efficacy of COVID-19. […] CD8+ T cells tended to be an independent predictor for COVID-19 severity and treatment efficacy. 2020-03-31
The correlation between viral clearance and biochemical outcomes of 94 COVID-19 infected discharged patients. Information on clinical signs and symptoms, medical treatment, virus clearance, and laboratory parameters including interleukin 6 (IL-6) and C-reactive protein were collected. […] Therapeutic regimens of IFN-α + lopinavir/ritonavir and IFN-α + lopinavir/ritonavir + ribavirin might be beneficial for treatment of COVID-19. […] Serum LDH or CK decline may predict a favorable response to treatment of COVID-19 infection. 2020-03-31
COVID-19 treatment by repurposing drugs until the vaccine is in sight. There is no specific treatment available and management is empirical. 2020-03-31
Novel coronavirus treatment with ribavirin: Groundwork for an evaluation concerning COVID-19. Confronting the challenge of the outbreak of COVID-19 should sharpen our focus on global drug access as a key issue in antiviral therapy testing. […] The apparent COVID-19 pandemic provides an opportunity to follow dosage guidelines for treatment with ribavirin, test new therapeutic concepts, and conduct controlled testing to apply the scientific rigor required to address the controversy around this mainstay of antiviral therapy. 2020-04-10
Migraine Care in the Era of COVID-19: Clinical Pearls and Plea to Insurers. To outline strategies for the treatment of migraine which do not require in-person visits to clinic or the emergency department, and to describe ways that health insurance companies can remove barriers to quality care for migraine. […] We focus on evidence-based treatment where possible, but also describe “real world” strategies which may be tried. 2020-04-13
The possible impact of COVID-19 on colorectal surgery in Italy. The COVID-19 outbreak in Italy is stopping access to elective benign disease treatment and changing the approach to malignant disease as well as the outpatients care of those patients treated for colorectal cancer. 2020-03-31
Covid-19 in Critically Ill Patients in the Seattle Region - Case Series. During the first 3 weeks of the Covid-19 outbreak in the Seattle area, the most common reasons for admission to the ICU were hypoxemic respiratory failure leading to mechanical ventilation, hypotension requiring vasopressor treatment, or both. 2020-04-16
Renin-angiotensin system inhibitors improve the clinical outcomes of COVID-19 patients with hypertension. We observed that patients receiving ACEI or ARB therapy had a lower rate of severe diseases and a trend toward a lower level of IL-6 in peripheral blood. […] In addition, ACEI or ARB therapy increased CD3 and CD8 T cell counts in peripheral blood and decreased the peak viral load compared to other antihypertensive drugs. 2020-04-02
Transcriptomic characteristics of bronchoalveolar lavage fluid and peripheral blood mononuclear cells in COVID-19 patients. The transcriptome dataset of COVID-19 patients would be a valuable resource for clinical guidance on anti-inflammatory medication and understanding the molecular mechansims of host response. 2020-04-02
COVID-19, ACE2, and the cardiovascular consequences. In lieu of the fact that many older patients with hypertension or other CVDs are routinely treated with RAAS blockers and statins, new clinical concerns have developed regarding whether these patients are at greater risk for SARS-CoV-2 infection, whether RAAS and statin therapy should be discontinued, and the potential consequences of RAAS blockade to COVID-19-related pathologies such as acute and chronic respiratory disease. 2020-04-16
Asymptomatic and Human-to-Human Transmission of SARS-CoV-2 in a 2-Family Cluster, Xuzhou, China. These findings might also serve as a practical reference for clinical diagnosis and medical treatment. 2020-04-01
How to reduce the likelihood of coronavirus-19 (CoV-19 or SARS-CoV-2) infection and lung inflammation mediated by IL-1. Therefore, drugs that suppress IL-1 or IL-1R, also used for the treatment of rheumatoid arthritis are to be taken into consideration to treat COVID-19. 2020-04-01
[Exploration of omics mechanism and drug prediction of coronavirus-induced heart failure based on clinical bioinformatics]. Finally, the apparently accurate treatment prediction platform (EpiMed) independently developed by the team was used to predict the therapeutic drug. Results: The GSE59185 coronavirus data set was searched and screened in the GEO database, and divided into wt group, ΔE group, Δ3 group, Δ5 group according to different subtypes, and compared with control group. […] The drugs predicted by EpiMed’s apparent precision treatment prediction platform for disease-drug association analysis are mainly TNF-α inhibitors, resveratrol, ritonavir, paeony, retinoic acid, forsythia, and houttuynia cordata. Conclusions: The abnormal activation of multiple inflammatory pathways may be the cause of heart failure in patients after coronavirus infection. 2020-04-01
Risk-adapted Treatment Strategy For COVID-19 Patients. The objective of this study is to investigate the short-term effect of risk-adapted treatment strategy on patients with COVID-19. […] We divided these patients into mild, moderate and severe groups, and risk-adapted treatment approaches were given according to the illness severity. […] Risk-adapted treatment strategy was associated with significant clinical manifestations alleviation and clinical imaging recovery. 2020-04-01
COVID-19 and chronological aging: senolytics and other anti-aging drugs for the treatment or prevention of corona virus infection? Similarly, two proposed therapeutics for the treatment of COVID-19 infection are Azithromycin and Quercetin, both drugs with significant senolytic activity. […] Therefore, we wish to speculate that the fight against COVID-19 disease should involve testing the hypothesis that senolytics and other anti-aging drugs may have a prominent role in preventing the transmission of the virus, as well as aid in its treatment. […] Thus, we propose that new clinical trials may be warranted, as several senolytic and anti-aging therapeutics are existing FDA-approved drugs, with excellent safety profiles, and would be readily available for drug repurposing efforts. […] As Azithromycin and Doxycycline are both commonly used antibiotics that inhibit viral replication and IL-6 production, we may want to consider this general class of antibiotics that functionally inhibits cellular protein synthesis as a side-effect, for the treatment and prevention of COVID-19 disease. 2020-04-01
Coronavirus Disease 19 Infection Does Not Result in Acute Kidney Injury: An Analysis of 116 Hospitalized Patients from Wuhan, China. The recorded information includes demographic data, medical history, contact history, potential comorbidities, symptoms, signs, laboratory test results, chest computer tomography scans, and treatment measures. […] In addition, 5 patients with CKD who were undergone regular continuous renal replacement therapy (CRRT) before admission were confirmed infection of SARS-CoV-2 and diagnosed as COVID-19. […] In addition to therapy for COVID-19, CRRT was also applied 3 times weekly during hospitalization for these 5 patients with CKD. […] In the course of treatment, the renal function indicators showed stable state in all 5 patients with CKD, without exacerbation of CKD, and pulmonary inflammation was gradually absorbed. 2020-04-01
Virology, Epidemiology, Pathogenesis, and Control of COVID-19. Scientific advancements since the pandemic of severe acute respiratory syndrome (SARS) in 2002~2003 and Middle East respiratory syndrome (MERS) in 2012 have accelerated our understanding of the epidemiology and pathogenesis of SARS-CoV-2 and the development of therapeutics to treat viral infection. […] As no specific therapeutics and vaccines are available for disease control, the epidemic of COVID-19 is posing a great threat for global public health. 2020-04-03
Inhibition of SARS-CoV-2 (previously 2019-nCoV) infection by a highly potent pan-coronavirus fusion inhibitor targeting its spike protein that harbors a high capacity to mediate membrane fusion. To develop specific anti-coronavirus therapeutics and prophylactics, the molecular mechanism that underlies viral infection must first be defined. […] Intranasal application of EK1C4 before or after challenge with HCoV-OC43 protected mice from infection, suggesting that EK1C4 could be used for prevention and treatment of infection by the currently circulating SARS-CoV-2 and other emerging SARSr-CoVs. 2020-04-07
Emerging prophylaxis strategies against COVID-19. WHO has accelerated research in diagnostics, vaccines and therapeutics for this novel coronavirus. 2020-04-02
Potential Treatments for COVID-19; a Narrative Literature Review. There is still no vaccine or definitive treatment for this virus because its pathogenesis and proliferation pathways are still unknown. 2020-04-04
Experience of Diagnosing and Managing Patients in Oral Maxillofacial Surgery during the Prevention and Control Period of the New Coronavirus Pneumonia. As one of the busiest specialised hospitals in the world, the Department of Oral and Maxillofacial Surgery of Peking University School and Hospital of Stomatology summarised the experience with disease prevention and control and clinical recommendations on the examination, diagnosis and treatment processes, clinical management, healthcare personnel protection and disinfection amid the continued spread of the pandemic. 2020-04-02
Safety Recommendations for Evaluation and Surgery of the Head and Neck During the COVID-19 Pandemic. The most common procedures related to the examination and treatment of upper aerodigestive tract diseases were reviewed. 2020-04-01
Balancing Health Privacy, Health Information Exchange and Research in the Context of the COVID-19 Pandemic. This paper discusses proposed changes to privacy regulations such as the Health Insurance Portability and Accountability act (HIPAA) designed to let health information seamlessly and frictionlessly flow between the health entities that need to collaborate on treatment of patients and, also, allow it to flow to researchers trying to understand how to limit its impacts. 2020-04-01
Characteristics of Ocular Findings of Patients With Coronavirus Disease 2019 (COVID-19) in Hubei Province, China. During the period of treatment, the ocular signs and symptoms as well as results of blood tests and reverse transcriptase-polymerase chain reaction (RT-PCR) from nasopharyngeal and conjunctival swabs for SARS-CoV-2 were noted and analyzed. 2020-04-04
The experience of high-flow nasal cannula in hospitalized patients with 2019 novel coronavirus-infected pneumonia in two hospitals of Chongqing, China. Most of the critically ill patients received high-flow nasal cannula (HFNC) oxygen therapy. […] Among them, 27 (8.4%) patients experienced severe acute respiratory failure including 17 patients (63%) treated with HFNC as first-line therapy, 9 patients (33%) treated with noninvasive ventilation (NIV) and one patient (4%) treated with invasive ventilation. […] HFNC failure was defined by the need of NIV or intubation as rescue therapy. […] After initiation of NIV as rescue therapy among the 7 patients with HFNC failure, PaO2/FiO2 significantly improved after 1-2 h of NIV [median 172 (150-208) mmHg vs. […] However, two out of seven (29%) patients with NIV as rescue therapy ultimately received intubation. 2020-04-03
Diabetes is a risk factor for the progression and prognosis of COVID-19. Demographic data, medical history, symptoms and signs, laboratory findings, chest computed tomography (CT) as well the treatment measures were collected and analysed. 2020-04-08
Covid-19 and diabetes mellitus: unveiling the interaction of two pandemics. Targeting the overexpression of Il-6 effects with a monoclonal antibody against IL-6 receptor or using Janus Kinase inhibitors may be particularly helpful for treatment of Covid-19 pneumonia in diabetes. 2020-04-14
Coronavirus pandemic and Colorectal surgery: practical advice based on the Italian experience. It is prudent to stop non-cancer procedures and prioritize urgent cancer treatment. 2020-04-02
Effects of media reporting on mitigating spread of COVID-19 in the early phase of the outbreak. The absence of specific therapeutic treatment or effective vaccine against COVID-19 call for other avenues of the prevention and control measures. 2020-04-09
Effect of delay in diagnosis on transmission of COVID-19. More rigorous prevention measures and better treatment of patients are needed to control its further spread, e.g., increasing available hospital beds, shortening the period from symptom onset to isolation of patients, quarantining and isolating the suspected cases as well as all confirmed patients. 2020-04-09
Network pharmacology-based analysis of the role of traditional Chinese herbal medicines in the treatment of COVID-19. Currently, no effective medical treatment exists to combat this disease. […] Traditional Chinese herbal medicines (CHM) have unique roles in the treatment of viral infections. 2020-04-13
Risk factors associated with disease progression in a cohort of patients infected with the 2019 novel coronavirus. All the patients received standardized treatment. 2020-04-13
Novel coronavirus in a 15-day-old neonate with clinical signs of sepsis, a case report. Antibiotic and antiviral treatment was initiated. 2020-04-16
Implications for Online Management: Two Cases with COVID-19. Satisfactory outcome was observed in one mild case and one severe case of COVID-19 pneumonia after the use of the online/offline multidisciplinary quarantine observation form, online monitoring, and classified diagnosis and treatment, as well as strict compliance with quarantine measures. […] The multidisciplinary self-quarantine model provides early judgment, identification, and treatment of disease, improves compliance with early rehabilitation, increases confidence in recovery, and enhances self-management capabilities. […] The application of this new management model is worthy of being promoted in our specialized treatment facilities and in countries with severe epidemics. 2020-04-02
[An epidemiologic thinking on the diagnosis criteria of COVID-19]. The current etiological test of COVID-19 cost long time, and have high false negative rate, may resulting delay the measures of disease treatment and prevention. 2020-04-02
[Analysis of CT features of 15 children with 2019 novel coronavirus infection]. After 3 to 5 days of treatment, 2019-nCoV nucleic acid in a second respiratory sample turned negative in 6 cases. 2020-04-03
Recent progress in understanding 2019 novel coronavirus (SARS-CoV-2) associated with human respiratory disease: detection, mechanisms and treatment. Here we scrutinise a series of available studies by global scientists on the clinical manifestations, detection methods and treatment options for the disease caused by SARS-CoV-2, named coronavirus disease 2019 (COVID-19), and also propose potential strategies for preventing the infection. 2020-04-15
Coronavirus disease 2019 (COVID-19): current status and future perspectives. Intensive research on the newly emerged SARS-CoV-2 is urgently needed to elucidate the pathogenic mechanisms and epidemiological characteristics and to identify potential drug targets, which will contribute to the development of effective prevention and treatment strategies. 2020-04-11
The cytokine release syndrome (CRS) of severe COVID-19 and Interleukin-6 receptor (IL-6R) antagonist Tocilizumab may be the key to reduce the mortality. Therefore, the treatment of cytokine storm has become an important part of rescuing severe patients. […] If it can block the signal transduction pathway of IL-6, it is expected to become a new method for the treatment of severe patients. 2020-04-09
The epidemiology, diagnosis and treatment of COVID-19. In addition, registered trials investigating treatment options for COVID-19 infection are listed. 2020-04-09
COVID-19 and Paediatric Inflammatory Bowel Diseases: Global Experience and Provisional Guidance (March 2020) from the Paediatric IBD Porto group of ESPGHAN. A third survey collected current practice of PIBD treatment. […] Eight PIBD children had COVID-19 globally, all with mild infection without needing hospitalization despite treatment with immunomodulators and/or biologics. […] No cases have been reported in China and South Korea but biologic treatment has been delayed in 79 children, of whom 17 (22%) had exacerbation of their IBD. […] Among the Porto group members, face-to-face appointments were often replaced by remote consultations but almost all did not change current IBD treatment. 2020-04-08
Novel Coronavirus Infection (COVID-19) in Humans: A Scoping Review and Meta-Analysis. Data on treatment options were limited. 2020-04-02
The First 75 Days of Novel Coronavirus (SARS-CoV-2) Outbreak: Recent Advances, Prevention, and Treatment. Although no vaccines have been discovered yet, a series of containment measures have been implemented by various governments, especially in China, in the effort to prevent further outbreak, whilst various medical treatment approaches have been used to successfully treat infected patients. […] On the basis of current studies, it would appear that the combined antiviral treatment has shown the highest success rate. […] This review aims to critically summarize the most recent advances in understanding the coronavirus, as well as the strategies in prevention and treatment. 2020-04-08
Respiratory physiotherapy in patients with COVID-19 infection in acute setting: a Position Paper of the Italian Association of Respiratory Physiotherapists (ARIR). The entire healthcare system had to respond promptly in a very short time to an exponential growth of the number of subjects affected by COVID-19 (Coronavirus disease 2019) with the need of semi-intensive and intensive care units. 2020-04-02
A new threat from an old enemy: Re‑emergence of coronavirus (Review). In the present review, we address current knowledge on coronaviruses from a short history to epidemiology, pathogenesis, clinical manifestation of the disease, as well as treatment and prevention strategies. 2020-04-02
Why the immune system fails to mount an adaptive immune response to a Covid -19 infection. As yet, effective treatment is unavailable. […] However, the results of preliminary studies and clinical trials are improving our understanding of the pathogenesis and treatment of Covid-19. 2020-04-02
Epidemiological analysis of COVID-19 and practical experience from China. Chinese medical staff have summarized a set of effective strategies and methods in the diagnosis and treatment of this disease that are worthy of reference for their international counterparts. 2020-04-10
Obesity and its Implications for COVID-19 Mortality. Furthermore, the rising prevalence of obesity in the US and prior experience of the impact of obesity on mortality from H1 N1 Influenza should increase the sensitivity of clinicians caring for patients with obesity and COVID-19 to the need for aggressive treatment of such patients. 2020-04-02
An assessment of United States dermatology practices during the COVID-19 outbreak. It is unknown if dermatologists are assisting with the public health officials’ recommendations for social distancing by closing their practice or limiting their practice to the treatment of emergency conditions. 2020-04-15
[From SARS to COVID-19: pathogens, receptor, pathogenesis and principles of the treatment]. Thus, treatment approaches should include antiviral and anti-proinflammatory cytokines, anti-infectious and life support therapies, especially in patients with severe diseases. 2020-04-02
[Coinfection between dengue and covid-19: need for approach in endemic zones.] Thus leading to a delay in the diagnosis of COVID-19 infection and further spread of the virus, since in most cases of Dengue there are no warning signs and treatment is ambulatory. 2020-04-08
Neurologists and Covid-19: A note on courage in a time of uncertainty. Neurologists are used to uncertainty - diagnoses are frequently challenging, too often there are limited treatment options, and unpredictable prognoses are our bread and butter. 2020-04-02
Novel Coronavirus 2019 (2019-nCoV) Infection: Part II - Respiratory Support in the Pediatric Intensive Care Unit in Resource-limited Settings. It is important to recognize the risk factors, categorize severity and provide early treatment. 2020-04-16
Current Status of Epidemiology, Diagnosis, Therapeutics, and Vaccines for Novel Coronavirus Disease 2019 (COVID-19). Currently, various diagnostic kits to test for COVID-19 are available and several repurposing therapeutics for COVID-19 have shown to be clinically effective. […] Here, we review the current status of epidemiology, diagnosis, treatment, and vaccine development for COVID-19. 2020-04-10
Clinical Features and Short-term Outcomes of 102 Patients with Corona Virus Disease 2019 in Wuhan, China. Epidemiological, clinical, radiological characteristics, underlying diseases, laboratory tests treatment, complications and outcomes data were collected. […] There was no difference in drug treatment rates between the survival and non-survival groups. […] There were no differences in mortality among those who did or did not receive antimicrobial or glucocorticoid drug treatment. 2020-04-02
Potential covalent drugs targeting the main protease of the SARS-CoV-2 coronavirus. Since the preclinical or clinical information of these identified drugs is already available, they might be ready for being clinically tested in the treatment of COVID-19. 2020-04-02
The versatile heparin in COVID-19. Coagulopathy in corona virus infection has been shown to be associated with high mortality with high D-dimers being a particularly important marker for the coagulopathy.1 In the latest paper from the same group, the use of anticoagulant therapy with heparin was shown to decrease mortality as well. 2 This is especially so in patients i) who have met the sepsis induced coagulopathy (SIC) criteria ≥4 (40.0% vs 64.2%, P=0.029) compared to those with SIC score <4 (29.0% vs 22.6%, P=0.419).or ii) with markedly elevated D-dimer (greater than six-fold at the upper limit of normal). 2020-04-02
Electronic Personal Protective Equipment: A Strategy to Protect Emergency Department Providers in the Age of COVID-19. Emergent policy changes related to telemedicine and the Emergency Medical Treatment and Labor Act (EMTALA) during the novel coronavirus pandemic (COVID-19) have created opportunities for technology-based clinical evaluation, which serves to conserve personal protective equipment (PPE) and protect emergency providers. 2020-04-02
Coronavirus disease 2019 (COVID-19): a clinical update. Apart from supportive care, no specific treatment has been established for COVID-19. 2020-04-02
How young patients with cancer perceive the Covid-19 (coronavirus) epidemic in Milan, Italy: is there room for other fears? While in our centre we did not change our approach to the treatment of our young cancer patients, we developed a qualitative survey to assess their perception of the risk and level of stress. 2020-04-09
Coronavirus disease 2019 in elderly patients: Characteristics and prognostic factors based on 4-week follow-up. Close monitoring and timely treatment should be performed for the elderly patients at high risk. 2020-04-14
Applying Palliative Care Principles to Communicate with Children about COVID-19. Palliative care teams may consider expanding their communication training and skillsets to help families consider caring ways to communicate with their children and grandchildren about the coronavirus. […] Palliative care teams are wise to encourage families to ground their communication with children on key values: honesty and trust, self-compassion, safety, sensitivity, connection, preparedness, community-building, recognition of death as a part of the lifecycle, and legacy. 2020-04-02
Creating a Palliative Care Inpatient Response Plan for COVID19 - The UW Medicine Experience. Therefore, palliative care is an important part of the response to this pandemic. […] UW Medicine developed a strategy to implement a palliative care response for a multi-hospital healthcare system that incorporates conventional capacity, contingency capacity, and crisis capacity. […] The strategy was developed by our palliative care programs with input from the healthcare system leadership. […] In this publication, we share our multi-faceted strategy to implement high-quality palliative care in the context of the COVID-19 pandemic that incorporates conventional, contingency, and crisis capacity and focuses on the areas of the hospital caring for the most patients: the emergency department, the intensive care units, and the acute care services. […] Strategy planning for delivery of high-quality palliative care in the context of the COVID-19 pandemic represents an important area of need for our healthcare systems. 2020-04-02
Telemedicine in the Time of Coronavirus. Within weeks, COVID-19 has transformed our practice of palliative care and clinical medicine as we know it. […] In this article, we share just-in-time tips to support palliative care clinicians and program leaders in providing the best care possible by telemedicine. 2020-04-02
Diagnostic Value and Key Features of Computed Tomography in Coronavirus Disease 2019. Since most patients with COVID-19 infection share typical imaging features, radiological examinations have an irreplaceable role in screening, diagnosis and monitoring treatment effects in clinical practice. 2020-04-03
Out-of-Hospital Cohort Treatment of Coronavirus Disease 2019 Patients with Mild Symptoms in Korea: an Experience from a Single Community Treatment Center. To allocate medical resources efficiently, Korea implemented a novel institution for the purpose of treating patients with cohort isolation out of hospital, namely the Community Treatment Center (CTC). 2020-04-06
Clinical Course and Outcomes of Patients with Severe Acute Respiratory Syndrome Coronavirus 2 Infection: a Preliminary Report of the First 28 Patients from the Korean Cohort Study on COVID-19. Six patients (21.4%) required supplemental oxygen therapy, but no one needed mechanical ventilation. 2020-04-06
Primary care management of the coronavirus (COVID-19). Mild cases can be managed at home with self-isolation, symptomatic treatment and follow-up if the disease worsens. 2020-04-08
Imaging and clinical features of patients with 2019 novel coronavirus SARS-CoV-2: A systematic review and meta-analysis. We aim to explore reliable evidence for the diagnosis and treatment of the COVID-19 by analyzing all the published studies by Chinese scholars on the clinical and imaging features in novel coronavirus pneumonia caused by SARS-CoV-2. 2020-04-10
Characteristics and Early Prognosis of COVID-19 Infection in Fracture Patients. Analyses of early prognosis were based on clinical outcomes and trends in laboratory results during treatment. […] Surgical treatment should be carried out cautiously or nonoperative care should be chosen for patients with fracture in COVID-19-affected areas, especially older individuals with intertrochanteric fractures. 2020-04-03
A Practical Approach to the Management of Cancer Patients During the Novel Coronavirus Disease 2019 (COVID-19) Pandemic: An International Collaborative Group. Many cancer patients frequently visit the hospital for treatment and disease surveillance. […] They may be immunocompromised due to the underlying malignancy or anticancer therapy and are at higher risk of developing infections. 2020-04-05
A familial cluster, including a kidney transplant recipient, of Coronavirus Disease 2019 (COVID-19) in Wuhan, China. Based on the severity of clinical symptoms, chest computer tomography findings and SARS-Cov-2 RNA test results, we admitted the husband to the respiratory intensive care unit (RICU) and used a treatment consisting of immunosuppressant reduction/cessation and low dose methylprednisolone-based therapy, and his wife to the respiratory isolation ward. 2020-04-03
COVID-19 in post-transplantation patients- report of two cases. Both patients were on immunosuppressant therapy and had stable graft function before COVID-19 infection. 2020-04-03
C-reactive protein levels in the early stage of COVID-19. COVID-19 is a new infectious disease, for which there is currently no treatment. 2020-04-15
Treatment with convalescent plasma for critically ill patients with SARS-CoV-2 infection. Although all the four patients (including a pregnant woman) recovered from SARS-CoV-2 infection eventually, randomized trials are needed to eliminate the effect of other treatments and investigate the safety and efficacy of convalescent plasma therapy. 2020-04-03
SARS-CoV-2, COVID-19 and inherited arrhythmia syndromes. Currently, there is no proven effective therapy against the virus, and the impact on other diseases is also uncertain, especially inherited arrhythmia syndrome. 2020-04-16
SARS-CoV-2 and Coronavirus Disease 2019: What We Know So Far. The scientific community raced to uncover the origin of the virus, understand the pathogenesis of the disease, develop treatment options, define the risk factors, and work on vaccine development. 2020-04-06
Emetine, Ipecac, Ipecac Alkaloids and Analogues as Potential Antiviral Agents for Coronaviruses. The COVID-19 coronavirus is currently spreading around the globe with limited treatment options available. […] This article presents the rationale for potentially using old drugs (emetine, other ipecac alkaloids or analogues) that have been used to treat amoebiasis in the treatment of COVID-19. […] This paper also discusses the known side effects of emetine and related compounds, how those side effects can be managed, and the optimal method of administration for the potential treatment of COVID-19. […] Given the serious and immediate threat that the COVID-19 coronavirus poses, our long history with emetine and the likely ability of emetine to reach therapeutic concentrations within the lungs, ipecac, emetine, and other analogues should be considered as potential treatment options, especially if in vitro studies confirm viral sensitivity. 2020-04-06
Primary stratification and identification of suspected Corona virus disease 2019 (COVID-19) from clinical perspective by a simple scoring proposal. In this Commentary, we would like to comment on the article titled “A rapid advice guideline for the diagnosis and treatment of 2019 novel coronavirus (2019-nCoV) infected pneumonia (standard version)” as a featured article in Military Medical Research. 2020-04-10
Updating the diagnostic criteria of COVID-19 “suspected case” and “confirmed case” is necessary. On 6 February 2020, our team had published a rapid advice guideline for diagnosis and treatment of 2019 novel coronavirus (2019-nCoV) infection, and this guideline provided our experience and make well reference for fighting against this pandemic worldwide. […] However, the coronavirus disease 2019 (COVID-19) is a new disease, our awareness and knowledge are gradually increasing based on the ongoing research findings and clinical practice experience; hence, the strategies of diagnosis and treatment are also continually updated. […] In this letter, we answered one comment on our guideline and provided the newest diagnostic criteria of “suspected case” and “confirmed case” according to the latest Diagnosis and Treatment Guidelines for COVID-19 (seventh version) that issued by the National Health Committee of the People’s Republic of China. 2020-04-10
Traditional Chinese Medicine: an effective treatment for 2019 novel coronavirus pneumonia (NCP). Meanwhile, Traditional Chinese Medicine can provide the more effective and personalized treatment via adjusting the specific medicine for each patient based on the different syndromes. […] In addition, TCM often has different effect on the distinct stages of diseases, contributing to the prevention, treatment and rehabilitation. […] Therefore, it is convinced that Traditional Chinese Medicine is an effective treatment for 2019 novel coronavirus pneumonia. 2020-04-08
Projecting hospital utilization during the COVID-19 outbreaks in the United States. Hospital beds, intensive care units (ICUs), and ventilators are vital for the treatment of patients with severe illness. […] In scenario analyses, we varied the delay from symptom onset to self-isolation, the proportion of symptomatic individuals practicing self-isolation, and the basic reproduction number R0 Without self-isolation, when R0 = 2.5, treatment of critically ill individuals at the outbreak peak would require 3.8 times more ICU beds than exist in the United States. 2020-04-04
How we treat patients with lung cancer during the SARS-CoV-2 pandemic: primum non nocere. To date, no effective treatment has been identified and management for critically ill patients relies on management in intensive care units. […] Therefore, the risk/benefit ratio of systemic anticancer treatment (SACT) has to be considered. […] For each patient, several factors including age and comorbidities, as well as the number of hospital visits for treatment, can influence this risk. […] We hereby propose a tool to support oncologists and physicians in treatment decision for patients with lung cancer. […] There are several variables to consider, including the extent of the epidemic, the local healthcare structure capacity, the risk of infection to the individual, the status of cancer, patients’ comorbidities, age and details of the treatment. 2020-04-10
Health services provision of 48 public tertiary dental hospitals during the COVID-19 epidemic in China. All the 48 public tertiary dental hospitals suspended general non-emergency dental treatment while providing emergency dental services only. 2020-04-04
Difference of coagulation features between severe pneumonia induced by SARS-CoV2 and non-SARS-CoV2. Whether patients with elevated D-dimer could benefit from anticoagulant treatment was evaluated. […] Patients with severe pneumonia induced by SARS-CoV2 had higher platelet count than those induced by non-SARS-CoV2, and only the former with markedly elevated D-dimer may benefit from anticoagulant treatment. 2020-04-04
Dealing with sleep problems during home confinement due to the COVID-19 outbreak: practical recommendations from a task force of the European CBT-I Academy. In this paper we summarize what is known about the stress-sleep link and confinement as well as effective insomnia treatment. […] We suggest adaptions of cognitive behavioral therapy elements that are feasible to implement for those facing changed work schedules and requirements, those with health anxiety and those handling childcare and homeschooling, whilst also recognizing the general limitations imposed on physical exercise and social interaction. 2020-04-04
Favipiravir: pharmacokinetics and concerns about clinical trials for 2019-nCoV infection. No specific antiviral drugs have been approved for the treatment of COVID-2019. 2020-04-04
The COVID-19 Pandemic: New Global Challenges for the Hemophilia Community. Over the past few decades, several blood-borne viruses have targeted hemophilia patients requiring treatment with clotting factors derived from human plasma [1]. 2020-04-04
Insight into 2019 novel coronavirus - an updated intrim review and lessons from SARS-CoV and MERS-CoV. Based on recently published literatures, official documents and selected up-to-date preprint studies, we reviewed the virology and origin, epidemiology, clinical manifestations, pathology and treatment of 2019-nCoV infection, in comparison with severe acute respiratory syndrome coronavirus (SARS-CoV) and middle east respiratory syndrome coronavirus (MERS-CoV) infection. 2020-04-07
Palliative Care Pandemic Pack: a Specialist Palliative Care Service response to planning the COVID-19 pandemic. Specialist Palliative Care services (SPCS) have a vital role to play in the global COVID-19 pandemic. […] SPCS resource capacity is likely to be overwhelmed, and consideration needs to be given to empowering and supporting high-quality primary palliative care in all care locations. […] Our local SPCS have developed a Palliative Care Pandemic Pack to disseminate succinct and specific information, guidance, and resources designed to enable the rapid up-skilling of non-specialist clinicians needing to provide palliative care. 2020-04-04
Recommendations for the surgical management of gynecological cancers during the COVID-19 pandemic - FRANCOGYN group for the CNGOF. For cervical cancer, radiotherapy and concomitant radiochemotherapy could replace surgery as first-line treatment and the value of lymph node staging should be reviewed on a case-by-case basis. 2020-04-13
Chloroquine and hydroxychloroquine in the treatment of COVID-19 with or without diabetes: A systematic search and a narrative review with a special reference to India and other developing countries. Considering minimal risk upon use, a long experience of use in other diseases, cost-effectiveness and easy availability across India, we propose that both these drugs are worthy of fast track clinical trial for treatment, and may be carefully considered for clinical use as experimental drugs. […] Since HCQ has been approved for treatment of diabetes in India, it should be further researched in diabetes and COVID-19, a subgroup where significant mortality has been shown. 2020-04-10
Contentious issues and evolving concepts in the clinical presentation and management of patients with COVID-19 infectionwith reference to use of therapeutic and other drugs used in Co-morbid diseases (Hypertension, diabetes etc). Search terms were, COVID-19, treatment of coronavirus, COVID 19 and following terms; chloroquine, hydroxychloroquine, ibuprofen, ACE-inhibitors or angiotensin receptor blockers, cardiovascular disease, diarrhoea, liver, testis and gastrointestinal disease. […] We discuss evidence regarding role of chloroquine and hydroxychloroquine in treatment and prophylaxis, use of inhibitors of the renin angiotensin system, safety of ibuprofen, unusual clinical features like gastrointestinal symptoms and interpretation of tests for cardiac enzymes and biomarkers. 2020-04-16
Unknown unknowns - COVID-19 and potential global mortality. This paper will attempt to estimate global infection rates and potential resultant mortality in the absence of effective treatment and/or vaccination. 2020-04-05
Remdesivir for severe acute respiratory syndrome coronavirus 2 causing COVID-19: An evaluation of the evidence. The first medication experience of the recovered patients in the US has led remdesivir to be the “specific drug”. […] China has also taken immediate action to put remdesivir into clinical trials with the purpose of applying it into clinical therapeutics for Corona Virus Disease 2019 (COVID-19). 2020-04-14
Use of DAMPs and SAMPs as Therapeutic Targets or Therapeutics: A Note of Caution. This opinion article discusses the increasing attention paid to the role of activating damage-associated molecular patterns (DAMPs) in initiation of inflammatory diseases and suppressing/inhibiting DAMPs (SAMPs) in resolution of inflammatory diseases and, consequently, to the future roles of these novel biomarkers as therapeutic targets and therapeutics. […] For example, we discuss the need to a priori identify and define a context-dependent “homeostatic DAMP:SAMP ratio” in each case and a “homeostatic window” of DAMP and SAMP concentrations to guarantee a safe treatment modality to patients. […] Finally, a few clinical examples of how DAMPs and SAMPs might be used as therapeutic targets or therapeutics in the future are discussed, including inhibition of DAMPs in hyperinflammatory processes (e.g., systemic inflammatory response syndrome, as currently observed in Covid-19), administration of SAMPs in chronic inflammatory diseases, inhibition of SAMPs in hyperresolving processes (e.g., compensatory anti-inflammatory response syndrome), and administration/induction of DAMPs in vaccination procedures and anti-cancer therapy. 2020-04-05
Global interim guidance on coronavirus disease 2019 (COVID-19) during pregnancy and puerperium from FIGO and allied partners: Information for healthcare professionals. We also provide guidance on the medical treatment of pregnant women with COVID-19 infection. 2020-04-05
Critically ill patients with COVID-19 in Hong Kong: a multicentre retrospective observational cohort study Three multidisciplinary intensive care units (ICUs) in Hong Kong. […] Six patients (75%) required mechanical ventilation, six patients (75%) required vasopressors and two (25%) required renal replacement therapy. 2020-04-06
The cardiovascular burden of coronavirus disease 2019 (COVID-19) with a focus on congenital heart disease. Given the novel nature of COVID-19, no established treatment beyond supportive care exists currently, but extensive public-health measures to reduce person-to-person transmission of COVID-19 have been implemented globally to curb the spread of disease, reduce the burden on healthcare systems, and protect vulnerable populations, including the elderly and those with underlying medical comorbidities. 2020-04-09
Neutralizing Antibodies against SARS-CoV-2 and Other Human Coronaviruses. To meet this challenge, this article discusses advances in the research and development of neutralizing antibodies (nAbs) for the prevention and treatment of infection by SARS-CoV-2 and other human CoVs. 2020-04-09
Identification of Kidney Transplant Recipients with Coronavirus Disease 2019. Four patients received a reduced dose of maintenance immunosuppressive therapy during hospitalization. […] Although greater patient numbers and long-term follow-up data are needed, our series demonstrates that mild COVID-19 infection in KTx recipients can be managed using symptomatic support therapy combined with adjusted maintenance immunosuppressive therapy. 2020-04-06
Recommendations and guidance for providing pharmaceutical care services during COVID-19 pandemic: A China perspective. Particularly, the community patient population are at high risk of infection and are facing potential failure of proper medication use during the pandemic. […] Pharmacists shall use various approaches to provide PC services in drug dispensing, consulting and referrals, chronic disease management, safe use of infusions, patient education, home care guidance and psychological support to promote the COVID-19 pandemic control and ensure safe medication use of community patients during the pandemic. […] Community pharmacies shall work as a strong supporter of patient’s medication and protective equipment supply. […] Community pharmacists shall be prepared to provide skilled and effective PC services for community patient population to ensure medication safety and promote the overall COVID-19 pandemic control. 2020-04-09
Macrolide treatment for COVID-19: Will this be the way forward? With no vaccines or drugs approved for prevention and treatment until now, all efforts at drug design and/or clinical trials of already approved drugs are worthy and creditable. […] Very recently, hydroxychloroquine in combination with azithromycin treatment was reported to be effective for COVID-19. 2020-04-06
Influenza and obesity: its odd relationship and the lessons for COVID-19 pandemic. Nonetheless, evidence from previous influenza pandemics suggests the following interventions aimed at improving immune response: (1) lose weight with a mild caloric restriction; (2) include AMPK activators and PPAR gamma activators in the drug treatment for obesity associated with diabetes; and (3) practice mild-to-moderate physical exercise. 2020-04-06
A comparative-descriptive analysis of clinical characteristics in 2019-Coronavirus-infected children and adults. Antiviral therapy was given to all adult patients but to none of the children. 2020-04-06
COVID-19 infection in a paucisymptomatic infant: Raising the index of suspicion in epidemic settings. We present the case of a 32-day-old boy infected by COVID-19 that presented with an upper air way infection which resolved spontaneously and did not require any therapy. 2020-04-06
Will plant-made biopharmaceuticals play a role in the fight against COVID-19? Plant biotechnology offers potential solutions to this pandemic through the development of low-cost vaccines and antibodies useful for therapy, prophylaxis, and diagnosis. 2020-04-16
Potential harmful effects of discontinuing ACE-inhibitors and ARBs in COVID-19 patients. Based on the current clinical evidence treatment with ACE-inhibitors I (ACEis) or angiotensin receptor blockers (ARBs) continues to provide cardiovascular and renal protection in patients diagnosed with COVID-19. 2020-04-15
[Consensus Report from Turkish Society of Cardiology: COVID-19 and Cardiovascular Diseases. What cardiologists should know. (25th March 2020)]. In December 2019, in the city of Wuhan, in the Hubei province of China, treatment-resistant cases of pneumonia emerged and spread rapidly for reasons unknown. 2020-04-10
Baseline Characteristics and Outcomes of 1591 Patients Infected With SARS-CoV-2 Admitted to ICUs of the Lombardy Region, Italy. To characterize patients with coronavirus disease 2019 (COVID-19) requiring treatment in an intensive care unit (ICU) in the Lombardy region of Italy. 2020-04-09
Lung transplantation as therapeutic option in acute respiratory distress syndrome for COVID-19-related pulmonary fibrosis. Lung transplantation (LT) as the sole therapy for end-stage pulmonary fibrosis related to acute respiratory distress syndrome has been considered as the ultimate rescue therapy for these patients. 2020-04-06
Current Drugs with Potential for Treatment of COVID-19: A Literature Review. PubMed, Google Scholar and Science Direct databases were searched Results: A total 22 articles were found eligible. 8 discuss about treatment outcomes from their applied drugs during treatment of COVID-19 patients, 4 report laboratory tests, one report animal trial and other 9 articles discuss recommendations and suggestions based on the treatment process and clinical outcomes of other diseases such as malaria, ebola, severe acute respiratory syndrome (SARS) and Middle East respiratory syndrome (MERS). 2020-04-13
Virtual screening and repurposing of FDA approved drugs against COVID-19 main protease. Ribavirin, telbivudine, vitamin B12 and nicotinamide can be combined and used for COVID treatment. […] This initiative relocates already marketed and approved safe drugs for potential use in COVID-treatment. 2020-04-16
The Role of Cytokines including Interleukin-6 in COVID-19 induced Pneumonia and Macrophage Activation Syndrome-Like Disease. This is distinct from HLH associated with immunodeficiency states termed primary HLH -with radically different therapy strategies in both situations. […] We discuss the potential impact of timing of anti-cytokine therapy on viral clearance and the impact of such therapy on intra-pulmonary macrophage activation and emergent pulmonary vascular disease. 2020-04-10
Structural and molecular modelling studies reveal a new mechanism of action of chloroquine and hydroxychloroquine against SARS-CoV-2 infection. Given the global health emergency, drug repositioning is the most reliable option to design an efficient therapy for infected patients without delay. […] Using a combination of structural and molecular modelling approaches, this study showed that chloroquine (CLQ), one of the drugs currently under investigation for SARS-CoV-2 treatment, binds sialic acids and gangliosides with high affinity. 2020-04-14
Remdesivir, lopinavir, emetine, and homoharringtonine inhibit SARS-CoV-2 replication in vitro. Combinational therapy may help to reduce the effective concentration of compounds below the therapeutic plasma concentrations and provide better clinical benefits. 2020-04-16
Extracorporeal membrane oxygenation (ECMO): does it have a role in the treatment of severe COVID-19? To date, no specific treatment has been proven to be effective for SARS-CoV-2 infection. […] Given to the previous experience, extracorporeal membrane oxygenation (ECMO) has been proven to be an effective therapy in the treatment of respiratory failure or acute respiratory distress syndrome (ARDS). […] On the basis of similar principle, ECMO may be also an effective therapy in the treatment of severe COVID-19. 2020-04-06
The enlightenment from two cases of asymptomatic infection with SARS-CoV-2: is it safe after 14 days of isolation? One patient was discharged within 14 days after treatment. […] Another patient was discharged 25 days after treatment, and his TR-PCR test was still positive on the 15th day. 2020-04-09
Evidence that Vitamin D Supplementation Could Reduce Risk of Influenza and COVID-19 Infections and Deaths. For treatment of people who become infected with COVID-19, higher vitamin D3 doses might be useful. 2020-04-10
Surgical Management of Patients With COVID-19 Infection. Recommendations of the Spanish Association of Surgeons. Due to the current pandemic of respiratory disease known as coronavirus disease 2019 (COVID-19) caused by the SARS-CoV-2 virus, many patients with confirmed or suspected COVID-19 infection will require elective surgery, surgery that cannot be postponed, or emergency surgical treatment. […] This document explains the main principles to consider when managing confirmed or suspected COVID-19 patients during evaluation as well as when surgical treatment is required. 2020-04-10
Recommendations for coronavirus infection in rheumatic diseases treated with biologic therapy. The management includes ventilatory support and broad-spectrum antiviral drugs, empirically utilized, as a targeted therapy and vaccines have not been developed. […] Checkpoints inhibitors such as anti-CD200 and anti-PD1 could have a role in the treatment of CoViD-19. […] Rheumatic disease patients taking immunosuppressive drugs should be recommended to maintain the chronic therapy, prevent infection by avoiding social contacts and pausing immunosuppressants in case of infection. 2020-04-15
Effectiveness of convalescent plasma therapy in severe COVID-19 patients. This study showed CP therapy was well tolerated and could potentially improve the clinical outcomes through neutralizing viremia in severe COVID-19 cases. […] The optimal dose and time point, as well as the clinical benefit of CP therapy, needs further investigation in larger well-controlled trials. 2020-04-07
Flavonoids isolated from loquat (Eriobotrya japonica) leaves inhibit oxidative stress and inflammation induced by cigarette smoke in COPD mice: the role of TRPV1 signaling pathways. Loquat leaves have long been used as an important material for both pharmaceutical and functional applications in the treatment of lung disease in Asia, especially in China and Japan. […] TF treatment significantly inhibited the level of malondialdehyde (MDA) and increased the activity of superoxide dismutase (SOD). […] It suggested that TF derived from loquat leaves could be considered to be an alternative or a new functional material and used for the treatment of CS-induced COPD. 2020-04-07
Tocilizumab treatment in COVID-19: A single center experience. Tocilizumab (TCZ), a monoclonal antibody against interleukin-6 (IL-6), emerged as an alternative treatment for COVID-19 patients with a risk of cytokine storms recently. […] In the present study, we aimed to discuss the treatment response of TCZ therapy in COVID-19 infected patients. […] The demographic, treatment, laboratory parameters of C-reactive protein (CRP) and IL-6 before and after TCZ therapy and clinical outcome in the 15 COVID-19 patients were retrospectively assessed. […] Although TCZ treatment ameliorated the increased CRP in all patients rapidly, for the four critically ill patients who received an only single dose of TCZ, three of them (No. 1, 2, and 3) still dead and the CRP level in the rest one patient (No. 7) failed to return to normal range with a clinical outcome of disease aggravation. […] Serum IL-6 level tended to further spiked firstly and then decreased after TCZ therapy in 10 patients. […] A persistent and dramatic increase of IL-6 was observed in these four patients who failed treatment. […] TCZ appears to be an effective treatment option in COVID-19 patients with a risk of cytokine storms. 2020-04-15
Generalized pustular figurate erythema: A newly delineated severe cutaneous drug reaction linked with hydroxychloroquine. It is distinguishable by its longer incubation period, more varied morphology with initially urticarial and later targetoid and arcuate plaques, recalcitrance to therapy and longer duration. 2020-04-16
Coronavirus COV-19/SARS-CoV-2 affects women less than men: clinical response to viral infection. It is hoped that certain drugs, such as CoV-19 receptor blockers, anti-inflammatories (against rheumatic diseases), monoclonal antibodies, anti-IL-1 and anti-IL-6, the remdesevir drug (analogue adenosine, effective against ebola), hydroxychloroquine (for the treatment of malaria) and vaccines, will open up new strategies and new therapeutic ways to combat this terrible virus. 2020-04-15
[Thoughts on the reform of preventive medicine education in the context of new medicine]. This article analyzes the challenges of medical education in the dilemma of “separation of medical treatment and prevention”, and the new requirements for preventive medical education in the construction of New Medicine under the Healthy China strategy. 2020-04-07
[Consideration of surgeons participating in COVID-19 emergency medical rescue]. As a newly epidemic, COVID-19 with a concentrated outbreak poses a great challenge to medical treatment. […] The surgeon participated in emergency medical rescue could provide professional treatment for the patients combined with surgical diseases, specialized training for the non-surgeon crew, to reduce surgical-related mortality. 2020-04-07
Deployment of convalescent plasma for the prevention and treatment of COVID-19. To date, there are no proven options for prophylaxis for those who have been exposed to SARS-CoV-2, nor therapy for those who develop COVID-19. […] There are numerous examples, where convalescent plasma has been used successfully as post-exposure prophylaxis and/or treatment of infectious diseases, including other outbreaks of coronaviruses (e.g., SARS-1, Middle East Respiratory Syndrome [MERS]). […] Data from rigorously controlled clinical trials of convalescent plasma are also few, underscoring the need to evaluate its use objectively for a range of indications (e.g., prevention vs treatment) and patient populations (e.g., age, comorbid disease). 2020-04-07
Hospitalization and Critical Care of 109 Decedents with COVID-19 Pneumonia in Wuhan, China. Demographic, clinical, laboratory, and treatment data were collected and analyzed, and final date of follow-up was February 24, 2020. 2020-04-07
Towards Optimization of Hydroxychloroquine Dosing in Intensive Care Unit COVID-19 Patients. Hydroxychloroquine (HCQ) appears to be a promising treatment for COVID-19. 2020-04-07
COVID-19 and the use of immunomodulatory and biologic agents for severe cutaneous disease: An Australia/New Zealand consensus statement. In patients with suspected or confirmed COVID-19 disease, all immunomodulators used for skin diseases should be immediately withheld, with the possible exception of systemic corticosteroid therapy, which needs to be weaned. 2020-04-07
Clinical trials on drug repositioning for COVID-19 treatment. More than 80 clinical trials have been launched to test coronavirus treatment, including some drug repurposing or repositioning for COVID-19. 2020-04-09
Associations between immune-suppressive and stimulating drugs and novel COVID-19-a systematic review of current evidence. No conclusive evidence for or against the use of non-steroidal anti-inflammatory drugs (NSAIDs) in the treatment of COVID-19 patients is available, nor is there evidence indicating that TNFα blockade is harmful to patients in the context of COVID-19. […] Although there are potential targets in the JAK-STAT pathway that can be manipulated in treatment for coronaviruses and it is evident that IL-1 is elevated in patients with a coronavirus, there is currently no evidence for a role of these drugs in treatment of COVID-19. […] The COVID-19 pandemic has led to challenging decision-making about treatment of critically unwell patients. 2020-04-09
Transplantation of ACE2- Mesenchymal Stem Cells Improves the Outcome of Patients with COVID-19 Pneumonia. Among them, two common and one severe patient were recovered and discharged in 10 days after treatment. […] After treatment, the peripheral lymphocytes were increased, the C-reactive protein decreased, and the overactivated cytokine-secreting immune cells CXCR3+CD4+ T cells, CXCR3+CD8+ T cells, and CXCR3+ NK cells disappeared in 3-6 days. […] Meanwhile, the level of TNF-α was significantly decreased, while IL-10 increased in MSC treatment group compared to the placebo control group. […] Thus, the intravenous transplantation of MSCs was safe and effective for treatment in patients with COVID-19 pneumonia, especially for the patients in critically severe condition. 2020-04-09
Mesenchymal Stem Cell Infusion Shows Promise for Combating Coronavirus (COVID-19)- Induced Pneumonia. Therefore, MSC therapy inhibiting the overactivation of the immune system and promoting endogenous repair by improving the lung microenvironment after the SARS-CoV-2 infection found in this study is striking. 2020-04-09
High-Dose Intravenous Immunoglobulin as a Therapeutic Option for Deteriorating Patients With Coronavirus Disease 2019. Until now, no definite effective treatment has been identified. 2020-04-09
Current knowledge about the antivirals remdesivir (GS-5734) and GS-441524 as therapeutic options for coronaviruses. In particular, the current coronavirus disease 2019 (COVID-19) pandemic has quickly intensified interest in developing treatment options to mitigate impact on human life. […] Remdesivir (GS-5734™) is a broad-spectrum antiviral drug that is now being tested as a potential treatment for COVID-19 in international, multi-site clinical trials. 2020-04-07
Daily Situation Report on Coronavirus disease (COVID-19) in Iran; March 17, 2020. Where needed, clients are referred to 16-hour treatment clinics, which are specifically set up for the diagnosis and treatment of the disease, to the hospitals, or will be treated at home. 2020-04-09
Metronidazole; a Potential Novel Addition to the COVID-19 Treatment Regimen. Therefore, studies with a large sample size are required to determine the efficacy of metronidazole in the treatment of COVID-19 infection. 2020-04-09
Pain Management Best Practices from Multispecialty Organizations during the COVID-19 Pandemic and Public Health Crises. Access to pain treatment has been called a fundamental human right by numerous organizations. 2020-04-07
Review of Emerging Pharmacotherapy for the Treatment of Coronavirus Disease 2019. As the incidence continues to rise at a rapid pace, critical care teams are faced with challenging treatment decisions. […] Urgent identification of potential treatment strategies is a priority. 2020-04-07
Infection and Rapid Transmission of SARS-CoV-2 in Ferrets. Thus, ferrets represent an infection and transmission animal model of COVID-19 that may facilitate development of SARS-CoV-2 therapeutics and vaccines. 2020-04-10
Urgent need for individual mobile phone and institutional reporting of at home, hospitalized, and intensive care unit cases of SARS-CoV-2 (COVID-19) infection. The only method to understand the clustering and the immediate hospital resource needs is mandatory, uniform, daily reporting of hospital censuses of COVID-19 cases admitted to hospital wards and intensive care units. 2020-04-10
Childhood Rheumatic Diseases and COVID-19 Pandemic: An Intriguing Linkage and a New Horizon Although several comorbidities such as hypertension, diabetes and cardiovascular diseases are defined as a risk factor for developing the acute respiratory syndrome and need for intensive care; immune-compromised situations such as rheumatic disease which require immunosuppressive treatment strikingly are not found to be a risk factor for more severe disease course. 2020-04-08
Current Status of Cell-Based Therapies for Respiratory Virus Infections: Applicability to COVID-19. Limited pre-clinical data suggest that systemic MSC administration can significantly reduce respiratory virus (Influenza strains H5N1 and H9N2)-induced lung injury, however, there are no available data in models of coronavirus respiratory infection.There are a rapidly increasing number of clinical investigations of cell-based therapy approaches for COVID-19. 2020-04-10
Subunit Vaccines Against Emerging Pathogenic Human Coronaviruses. This review was written for the topic of Antivirals for Emerging Viruses: Vaccines and Therapeutics in the Virology section of Frontiers in Microbiology. 2020-04-10
PCR Assays Turned Positive in 25 Discharged COVID-19 Patients. We describe correlations between laboratory parameters and treatment duration (r= -0.637; p=0.002) and time to virus recrudescence (r= 0.52; p=0.008) respectively, suggesting the need for additional measures to confirm illness resolution in COVID-19 patients. 2020-04-08
Renin-Angiotensin System Inhibition in Cardiovascular Patients at the Time of COVID19: Much Ado for Nothing? A Statement of Activity from the Directors of the Board and the Scientific Directors of the Italian Society of Hypertension. Cardiovascular diseases, in particular hypertension, as well as the cardiovascular treatment with Renin-Angiotensin System inhibitors such as Angiotensin Converting Enzyme (ACE) inhibitors and Angiotensin Receptor Blockers (ARBs), are claimed once again as mechanisms of Severe Acute Respiratory Syndrome (SARS) during the COVID-19 outbreak due to Cov-2 epidemics. 2020-04-16
Corticosteroid treatment of patients with coronavirus disease 2019 (COVID-19). To assess the efficacy of corticosteroid treatment of patients with coronavirus disease 2019 (COVID-19). […] Virus clearance time, length of hospital stay, and duration of symptoms, by treatment type (including or not including corticosteroid therapy). […] Eleven of 31 patients with COVID-19 received corticosteroid treatment. […] Cox proportional hazards regression analysis indicated no association between corticosteroid treatment and virus clearance time (hazard ratio [HR], 1.26; 95% CI, 0.58-2.74), hospital length of stay (HR, 0.77; 95% CI, 0.33-1.78), or duration of symptoms (HR, 0.86; 95% CI, 0.40-1.83). […] Corticosteroids are widely used when treating patients with COVID-19, but we found no association between therapy and outcomes in patients without acute respiratory distress syndrome. 2020-04-08
Comment on “Organ-protective Effect of Angiotensin-converting Enzyme 2 and its Effect on the Prognosis of COVID-19”. In addition, we would like to mention that amiloride, which increases the cytosolic pH, can be used in the COVID-19 treatment. 2020-04-08
[Coronavirus and COVID-19 : focus on a galopping pandemic]. In the absence of specific anti-viral molecules, treatment is currently mainly symptomatic. 2020-04-09
Hsa-miR-217 Inhibits the Proliferation, Migration and Invasion in Non-small-cell Lung Cancer Cells Via Targeting SIRT1 and p53/KAI1 Signaling This axis might be a potential target for the treatment of brain metastasis of lung cancer. 2020-04-09
COVID-19: Important Therapy Considerations and Approaches in this Hour of Need. A number of novel and repurposed therapies agents with activity against SARS-CoV-2 have been identified and most institutions have developed clinical pathways to operationalize their use in appropriate COVID-19 patients.1-3 However, optimal drug therapy decisions for those with moderate to severe COVID-19 infections are extremely challenging at this time as evidence is limited. 2020-04-08
Considerations for statin therapy in patients with COVID-19. The main mechanism of ARDS is uncontrolled systemic inflammatory response and cytokine storm following release of proinflammatory cytokines (such as interferons (IFN), interleukines (IL), tumor necrosis factor (TNF)-α) and chemokines.2-3 So, some Chinese researchers proposed or used anti-inflammatory agents in the treatment regimen of patients with COVID-19.3-4. 2020-04-08
Therapeutic Potential for Tetracyclines in the Treatment of COVID-19. Based on the available evidence we believe that tetracyclines may be effective agents in the treatment of COVID-19. 2020-04-08
The Randomized Embedded Multifactorial Adaptive Platform for Community-acquired Pneumonia (REMAP-CAP) Study: Rationale and Design. Here, we present the rationale and design of a large, international trial that combines features of adaptive platform trials with pragmatic point-of-care trials to determine best treatment strategies for patients admitted to an intensive care unit with severe community-acquired pneumonia (CAP). […] The trial randomizes patients to multiple interventions within 4 treatment domains: antibiotics, antiviral therapy for influenza, host immunomodulation with extended macrolide therapy, and alternative corticosteroid regimens, representing 240 treatment regimens. 2020-04-09
Immune responses and pathogenesis of SARS-CoV-2 during an outbreak in Iran: Comparison with SARS and MERS. At present, there is no specific antiviral therapy for COVID-19 and the main treatments are supportive. 2020-04-08
Tissue Plasminogen Activator (tPA) Treatment for COVID-19 Associated Acute Respiratory Distress Syndrome (ARDS): A Case Series. There is evidence in both animals and humans that fibrinolytic therapy in Acute Lung Injury and ARDS improves survival, which also points to fibrin deposition in the pulmonary microvasculature as a contributory cause of ARDS and would be expected to be seen in patients with ARDS and concomitant diagnoses of DIC on their laboratory values such as what is observed in more than 70% of those who die of COVID-19 (8-10). 2020-04-08
Hydroxychloroquine for treatment of SARS-CoV-2 infection? Improving our confidence in a model-based approach to dose selection. Therapeutics are desperately needed to reduce the morbidity and mortality of this pandemic disease. […] It has been reported that hydroxychloroquine (HCQ) is active against SARS-CoV-2 in vitro, and this finding was quickly supported by an open label non-randomized clinical trial that provided the first published clinical evidence HCQ may be a treatment option. 2020-04-11
[Analysis of medication characteristics of traditional Chinese medicine in treating coronavirus disease-19 based on data mining]. To analysis the medication characteristics of the prescriptions issued via open channel by the National and Provincial Health Committee and the State Administration of Traditional Chinese Medicine in treating coronavirus disease 2019 (COVID-19). […] We collected the data of traditional Chinese medicine related to treatment plans published by the National and Provincial Health Committee and the State Administration of Traditional Chinese Medicine from the start of COVID-19 outbreak in Wuhan to February 19, 2020. […] The study collected 4 national and 34 regional prevention and treatment plans, 578 items, 84 traditional Chinese formulations, 60 Chinese patent medicines, and 230 Chinese herbs. […] The main medication characteristics are clearing heat, entilating lung, removing toxicity and removing turbidity. 2020-04-10
[Clinical experience of high-flow nasal cannula oxygen therapy in severe corona virus disease 2019 (COVID-19) patients]. We applied HFNC for oxygen therapy in severe and critical COVID-19 patients and summarized the following experiences. […] Thirdly, to avoid hypoxia or hypoxemia, the treatment goal of HFNC should be maintained the oxygen saturation (SpO2) above 95% for patients without chronic pulmonary disease. […] Finally, patients should wear a surgical mask during HFNC treatment to reduce the risk of virus transmission through droplets or aerosols. 2020-04-10
[Treatment experience of burn patients combined with inhalation injury during epidemic period of Corona Virus Disease 2019]. Objective: To introduce Treatment experience of burn patients combined with inhalation injury during epidemic period of Corona Virus Disease 2019 (COVID-19). Methods: Six burn patients combined with inhalation injury were hospitalized in Department of Burns of Tongren Hospital of Wuhan University& Wuhan Third Hospital from February 1 to March 1 in 2020duringhigh-incidence period of COVID-19, including 4 males and 2 females, aged 21-63 years, hospitalized for 2-4 hours, with total burn areas of 1%-20% TBSA and full-thickness burn areas of 1%-12% TBSA. […] After admission, 6 patients were given routine treatment, the medical staffs paid attention to the protection and screened COVID-19 according to the diagnosis and treatment plan of COVID-19. […] After treatment for 14-32 days, 6 patients were cured and discharged. Conclusions: During the novel coronavirus, burn patients combined with inhalation injury should be treated under condition of good protection for COVID-19 among doctors and nurses. 2020-04-08
In Silico Discovery of Candidate Drugs against Covid-19. Finally, we focused on the genes in the network that are already associated with known drugs and evaluated their role for a potential treatment of Covid-19. […] Among possible interesting drugs for Covid-19 treatment, we found Nimesulide, Fluticasone Propionate, Thiabendazole, Photofrin, Didanosine and Flutamide. 2020-04-13
[Health protection guideline of mobile cabin hospitals during COVID-19 outbreak]. This guideline is applicable to the health protection requirements of large indoor stadiums which are reconstructed as treatment sites for COVID-19 patients with mild symptoms during the outbreak. 2020-04-10
Intubation and mechanical ventilation of patients with COVID-19: what should we tell them? Severe COVID-19 illness is characterised by the development of Acute Respiratory Distress Syndrome (ARDS), for which the mainstay of treatment is represented by mechanical ventilation. 2020-04-10
Traditional Chinese herbal medicine for treating novel coronavirus (COVID-19) pneumonia: protocol for a systematic review and meta-analysis. The virus first appeared in Wuhan, China, in late December 2019, and traditional Chinese herbal medicine is being used for its treatment. […] The use of traditional Chinese herbal medicine for treatment or prevention of these novel viral infections affecting the pneumonia will be investigated. 2020-04-14
Novel Coronavirus Infection in Newborn Babies Under 28 Days in China. Supportive treatment was provided for all 4 newborn babies. 2020-04-11
Upheaval in cancer care during the COVID-19 outbreak. He was undergoing chemotherapy and had just returned to Nigeria following medical treatment in the United Kingdom. 2020-04-11
Anosmia and ageusia are emerging as symptoms in patients with COVID-19: What does the current evidence say? This is of particular interest in oncology since patients receiving some cancer treatments such as chemotherapy or immune therapy often experience similar symptoms as side-effects. […] Whilst more data is currently needed to strengthen our knowledge of the symptoms of COVID-19, oncology patients who are concerned about anosmia or ageusia in the context of their systemic anti-cancer therapy should contact their acute oncology support line for advice. 2020-04-09
A Comprehensive Literature Review on the Clinical Presentation, and Management of the Pandemic Coronavirus Disease 2019 (COVID-19). The penultimate portion of the review aims to explain the involvement of micronutrients such as vitamin C and vitamin D in COVID19 treatment and prophylaxis. 2020-04-11
Acute stroke management pathway during Coronavirus-19 pandemic. We would like to share our experience and send a clear message to keep a high attention on stroke as an emergency condition, because we have observed a decreased number of patients with minor strokes and TIAs, longer onset-to-door and door-to-treatment times for major strokes, and a reduced number of transfers from spokes. 2020-04-11
Coronavirus: Update Related to the Current Outbreak of COVID-19. To date, there is no specific therapy for COVID-19. 2020-04-09
Does recombinant human Erythropoietin administration in critically ill COVID-19 patients have miraculous therapeutic effects? He received antiviral treatment plus recombinant human Erythropoietin(rhEPO) due to his severe anemia. […] After 7 days of treatment, he was discharged with miraculous improvement in his symptoms and hemoglobin level. 2020-04-09
Clinical characteristics of a case series of children with coronavirus disease 2019. Five (50.0%) patients received antiviral treatment. 2020-04-09
Factors associated with prolonged viral RNA shedding in patients with COVID-19. When comparing patients with early (<15 days) and late viral RNA clearance (≥15 days after illness onset), prolonged SARS-CoV-2 RNA shedding was associated with male sex (p=0.009), old age (p=0.033), concomitated with hypertension (p=0.009), delayed admission to hospital after illness onset (p=0.001), severe illness at admission (p=0.049), invasive mechanical ventilation (p=0.006), and corticosteroid treatment (p=0.025). 2020-04-09
Utilizing integrating network pharmacological approaches to investigate the potential mechanism of Ma Xing Shi Gan Decoction in treating COVID-19. Employing combined therapy of modern medicine and traditional Chinese medicine has been proposed, in which Ma Xing Shi Gan Decoction (MXSGD) was recommended as a basic prescription and applied widely in the clinical treatment of COVID-19. 2020-04-15
Successful treatment of COVID-19 using extracorporeal membrane oxygenation, a case report. The treatment of severe COVID-19 patients has been rarely reported. 2020-04-15
Clinical efficacy of lopinavir/ritonavir in the treatment of Coronavirus disease 2019. Both groups achieved good therapeutic effect with the body temperature of patients decreased gradually from admission to the 10th day of treatment. […] The number of days for nCoV-RNA turning negative after treatment was significantly decreased in the test group than that in the control group. […] Compared with the treatment of pneumonia-associated adjuvant drugs alone, the combination treatment with LPV/r and adjuvant drugs has a more evident therapeutic effect in lowering the body temperature and restoring normal physiological mechanisms with no evident toxic and side effects. […] In view of these conclusions, we suggested that the use of LPV/r combined with pneumonia-associated adjuvant drugs in the clinical treatment for patients with COVID-19 should be promoted. 2020-04-15
A classifier prediction model to predict the status of Coronavirus COVID-19 patients in South Korea. The status of the infected cases can be determined basing on the treatment process along with several other factors. 2020-04-15
Clinical characteristics of 161 cases of corona virus disease 2019 (COVID-19) in Changsha. A retrospective analysis was performed on the confirmed cases of COVID-19, who were admitted to the North Hospital of Changsha first Hospital (Changsha Public Health treatment Center) from January 17 to February 7, 2020. 2020-04-15
A primer on viral-associated olfactory loss in the era of COVID-19. Practical suggestions regarding evaluation and treatment will be provided, realizing that there may be constraints on medical resources and the nature of this pandemic remains dynamic. 2020-04-09
COVID19 Prevention & Care; A Cancer Specific Guideline. One of the groups that is considered high risk in this pandemic are cancer patients as they are treated with a variety of immune system suppressor treatment modalities and this puts them in a great risk for infectious disease (including COVID-19). […] This article provides the recommendations and possible actions that should be considered by patients, their caregivers and families, physician, nurses, managers and staff of medical centers involved in cancer diagnosis and treatment. […] We pursued two major goals in our recommendations: first, limiting the exposure of cancer patients to medical environments and second, modifying the treatment modalities in a manner that reduces the probability of myelosuppression such as delaying elective diagnostic and therapeutic services, shortening the treatment course, or prolonging the interval between treatment courses. 2020-04-14
Epidemiology and Clinical Characteristics of COVID-19. Since there is no specific drug for COVID-19, the treatment is mainly symptomatic supportive therapy. […] In addition, it should be pointed out that patients with severe illness need more aggressive treatment and meticulous care. 2020-04-14
Coronavirus membrane fusion mechanism offers as a potential target for antiviral development. The conserved nature of the fusion domain and mechanism across the CoV family make it a valuable target to elucidate and develop pan-CoV therapeutics. 2020-04-09
The possible of immunotherapy for COVID-19: A systematic review. Since the outbreak of COVID-19, international attention has raised to develop treatment and control options such as types of immunotherapies. 2020-04-15
Structure of Mpro from COVID-19 virus and discovery of its inhibitors. Currently there are no targeted therapeutics and effective treatment options remain very limited. 2020-04-09
Lung Involvement Found on Chest CT Scan in a Pre-Symptomatic Person with SARS-CoV-2 Infection: A Case Report. His condition deteriorated initially, but eventually improved with supportive treatment and the compassionate use of antivirals and antimalarials and is now in a stable condition. 2020-04-10
Role of Tissue Engineering in COVID-19 and Future Viral Outbreaks. Impact statement Given the steep mortality caused by the recent novel coronavirus (COVID-19) pandemic, there is clear need for advances in diagnostics and therapeutics for viral outbreaks. 2020-04-15
Hospital pharmacists’ pharmaceutical care for hospitalized patients with COVID-19: Recommendations and guidance from clinical experience. Hospital pharmacists shall support pharmaceutical care services by participating in making evidence-based decisions for medication, monitoring and evaluation of medication safety and efficacy, providing strengthened care for special population and patients with combined underlying diseases, monitoring and management of convalescent plasma therapy, providing emotional counselling and psychological support, and providing scientific information about COVID-19 vaccines. 2020-04-13
Serial Computed Tomography Manifestations in a Child with Coronavirus Disease (COVID-19) Pneumonia. Computed tomography (CT) manifestations and treatment of children with COVID-19 are still unclear. 2020-04-10
Coronavirus Disease (COVID-19) in Children - What We Know So Far and What We Do Not? This review additionally considers COVID-19 in immunosuppressed children, and also suggests a management algorithm for the few children who appear to present with life threatening infection, including the potential use of antiviral and immunomodulatory treatment. 2020-04-10
Characteristics and Mechanism of Liver Injury in 2019 Coronavirus Disease. In this review, we highlight these important issues based on the recent developments in the field, for optimizing the management and treatment of liver injury in Chinese patients with COVID-19. 2020-04-13
COVID-19 and Liver Dysfunction: Current Insights and Emergent Therapeutic Strategies. Based on the current evidence from case reports and case series, this review article focuses on the demographic and clinical characteristics, potential mechanisms, and treatment options for COVID-19-related liver dysfunction. 2020-04-13
Inpatient and outpatient case prioritization for patients with neuro-oncologic disease amid the COVID-19 pandemic: general guidance for neuro-oncology practitioners from the AANS/CNS Tumor Section and Society for Neuro-Oncology. Here, we provide a framework for institutions and governments to help adjudicate treatment allocations to patients with neuro-oncologic disease. 2020-04-13
Corticosteroid Guidance for Pregnancy during COVID-19 Pandemic. Corticosteroid use is a mainstay of therapy for those women delivering prematurely. […] · Corticosteroid use is an important part of prematurity treatment because it provides benefit to the fetus.. 2020-04-10
[SARS CoV-2/COVID-19: Evidence-Based Recommendation on Diagnosis and Therapy]. In about 20% of patients, severe symptoms occur after a mean incubation period of 5 - 6 days; 5% of patients need intensive care therapy. […] Therapy is based on established recommendations issued for patients with acute lung injury (ARDS). […] Lung protective ventilation, prone position, restrictive fluid management and an adequate management of organ failures are the mainstays of therapy. 2020-04-13
[Obstetric Anesthesia During the SARS-CoV-2 Pandemic - a Brief Overview of Published Recommendations for Action by National and International Specialist Societies and Committees]. The general treatment principles in dealing with COVID-19 patients and the recommendations for action in intensive care therapy also apply to pregnant and postpartum patients. 2020-04-13
[Roles of multidisciplinary team (MDT) in diagnosis and treatment of suspected cases of corona virus disease 2019 (COVID-19)]. To analyze the roles of multidisciplinary team (MDT) in the diagnosis and treatment of suspected cases of corona virus disease 2019 (COVID-19). […] With the guidance of MDT, one COVID-19 patient was transferred to designated provincial hospital after effective treatment; one patient complicated with acute cholecystitis underwent gallbladder puncture and drainage; and COVID-19 was excluded in a highly suspected patient after alveolar lavage fluid examination. […] The efficiency of diagnosis and treatment for suspected COVID-19 patients can be improved under MDT mode, particularly for complicated and refractory cases. 2020-04-13
Vademecum for the treatment of people with COVID-19. Edition 2.0, 13 March 2020. However, no specific drug has been previously approved for the COVID-19 treatment. […] The Lombardy Section of the Italian Society of Infectious and Tropical Diseases provided this «vademecum» with the aim to explore the current evidence about the drugs likely to be efficacious in the treatment of COVID-19. […] Lastly, a collaborating group with immunologists and rheumatologists has been built with the aim of providing some guidance about the use of tocilizumab, a promising option for the treatment of the hyperinflammatory state occurring in most patients affected by COVID-19. 2020-04-15
Clinical manifestation, diagnosis, prevention and control of SARS-CoV-2 (COVID-19) during the outbreak period. Radiological and serological methods are the most preferred among the other methods and the radiological method is the most preferred one which can diagnose the infection quickly and accurately with fewer false-negatives, that can be effective in protecting the patient’s life by initiating treatment and preventing the transmission of infection to other people. 2020-04-15
Association of Public Health Interventions With the Epidemiology of the COVID-19 Outbreak in Wuhan, China. Rates of laboratory-confirmed COVID-19 infections (defined as the number of cases per day per million people), across age, sex, and geographic locations were calculated across 5 periods: December 8 to January 9 (no intervention), January 10 to 22 (massive human movement due to the Chinese New Year holiday), January 23 to February 1 (cordons sanitaire, traffic restriction and home quarantine), February 2 to 16 (centralized quarantine and treatment), and February 17 to March 8 (universal symptom survey). 2020-04-14
COVID-19 with Different Severity: A Multi-center Study of Clinical Features. We compared the clinical characteristics, laboratory examinations, CT images and treatment of COVID-19 patients from three different cities in China. 476 patients were recruited from Jan 1 to Feb 15, 2020 at three hospitals in Wuhan, Shanghai and Anhui. […] Patients were divided into four groups according to age and into three groups (moderate, severe, and critical group) according to the fifth version of the guidelines issued by the National Health Commission of China on Diagnosis and Treatment of COVID-19. 2020-04-10
Attitudes of Anesthesiology Specialists and Residents Toward Patients Infected with the Novel Coronavirus (COVID-19): A National Survey Study. Anesthesiology specialists and residents who perform emergency operations on these patients in settings other than intensive care units should follow simple and easy-to-understand algorithms to ensure safety. 2020-04-10
Aerosol and Surface Distribution of Severe Acute Respiratory Syndrome Coronavirus 2 in Hospital Wards, Wuhan, China, 2020. Contamination was greater in intensive care units than general wards. 2020-04-10
ILROG Emergency Guidelines for Radiation Therapy of Hematological Malignancies During the COVID-19 Pandemic. The ILROG guidelines for using radiation therapy in hematological malignancies are widely used in many countries. […] The emergency situation created by the COVID-19 pandemic may result in limitations of treatment resources. […] Furthermore, in recognition of the need to also reduce the exposure of patients and staff to potential infection with COVID-19, the ILROG task force has made recommendations for alternative radiation treatment schemes. 2020-04-10
Plasminogen improves lung lesions and hypoxemia in patients with COVID-19. Levels of their lung lesions, oxygen saturation and heart rates were compared before and after treatment by CT scanning images and patient monitor. 2020-04-10
Management of ovarian cancer during the COVID-19 pandemic. Entire hospitals have been converted into intensive care units, retired anesthesiologists have been called back to work, and specialists in other branches have been assigned to assist COVID-19 patients. 2020-04-10
Telemedicine in Liver Disease and Beyond: Can the COVID-19 Crisis Lead to Action? Telemedicine, defined as the delivery of health care services at a distance using electronic means for diagnosis and treatment, holds tremendous promise to increase access to broadly specialty care. 2020-04-10
Clinical and ethical challenges for emergency departments during communicable disease outbreaks: can lessons from Ebola Virus Disease be applied to the COVID-19 pandemic? The study exposes the tension between a healthcare worker’s right to protection and a duty to provide treatment. 2020-04-10
Compassionate Use of Remdesivir for Patients with Severe Covid-19. Patients received a 10-day course of remdesivir, consisting of 200 mg administered intravenously on day 1, followed by 100 mg daily for the remaining 9 days of treatment. […] Of the 61 patients who received at least one dose of remdesivir, data from 8 could not be analyzed (including 7 patients with no post-treatment data and 1 with a dosing error). […] Measurement of efficacy will require ongoing randomized, placebo-controlled trials of remdesivir therapy. 2020-04-10
Type 1 interferons as a potential treatment against COVID-19. In this review, we discuss preliminary data concerning the potential activity of type 1 interferons on SARS-CoV-2, and the relevance of evaluating these molecules in clinical trials for the treatment of COVID-19. 2020-04-16
Which Melbourne metropolitan areas are vulnerable to COVID-19 based on age, disability and access to health services? Using spatial analysis to identify service gaps and inform delivery. Ageing adults (65+) with disability are especially vulnerable to COVID-19 and upon contracting, are a cohort most likely to require palliative care. […] Therefore, it is very important that health services - particularly health services providing palliative care - are proximately available. […] The geographic dispersion of areas with people vulnerable to COVID-19 with poor access to palliative care and health services are clarified. […] The spatial methodology employed can be implemented in different contexts to support evidence-based COVID-19 and pandemic palliative care service decisions. 2020-04-13
Rapid De-Escalation and Triaging Patients in Community-Based Palliative Care. Palliative care teams who practice in the community setting are faced with a difficult task: How do we actively triage the most urgent visits while keeping our vulnerable patients safe from the pandemic? […] The following are recommendations created by the Palo Alto Medical Foundation Palliative Care and Support Services team to help triage and coordinate for timely, safe, and effective palliative care in the community and outpatient setting during the ongoing COVID-19 pandemic. […] We recommend active triaging, communication, frequent screening for COVID-19 symptoms for palliative care patients been evaluated in the community setting. […] An understanding of infection risk, mutual consent between designated providers, patients, and their families are crucial to maintaining safety while delivering community-based palliative care during the COVID-19 pandemic. 2020-04-12
Crisis Symptom Management and Patient Communication Protocols Are Important Tools for All Clinicians Responding to COVID-19. While palliative care specialists have training in these skills, many front-line clinicians from other specialties do not. 2020-04-13
Individual risk management strategy and potential therapeutic options for the COVID-19 pandemic. While specific treatment is not yet coming soon, individual risk assessment and management strategies are crucial. 2020-04-13
Epigenetic dysregulation of ACE2 and interferon-regulated genes might suggest increased COVID-19 susceptibility and severity in lupus patients. In this report we suggest that patients with systemic lupus erythematous might be especially prone to severe COVID-19 independent of their immunosuppressed state from lupus treatment. […] Epigenetic control of the ACE2 gene might be a target for prevention and therapy in COVID-19. 2020-04-13
Prolonged viral shedding in feces of pediatric patients with coronavirus disease 2019. Epidemiological, clinical, laboratory, and radiological characteristics and treatment data were collected. 2020-04-14
TMPRSS2 and COVID-19: Serendipity or opportunity for intervention? The modulation of its expression by sex steroids could contribute to the male predominance of severe infections and given that TMPRSS2 has no known indispensable functions, and inhibitors are available, it is an appealing target for prevention or treatment of respiratory viral infections. 2020-04-11
Cancer Care Goes Virtual in Response to COVID-19. Amid concerns over the spread of COVID-19, oncology practices have “gone virtual,” with video appointments scheduled for any service that does not require diagnostic testing or treatment. 2020-04-11
Structure of the RNA-dependent RNA polymerase from COVID-19 virus. The structure provides a basis for the design of new antiviral therapeutics targeting viral RdRp. 2020-04-11
Halting coronavirus polymerase. The nucleotide analogue remdesivir is an investigational drug for the treatment of human coronavirus infection. 2020-04-13
Managing Cutaneous Immune-Mediated Diseases During the COVID-19 Pandemic. The outbreak of COVID-19 affects the management of these chronic conditions, not only for those who are already receiving treatment but also for those who are about to start a new treatment to control their disease. 2020-04-11
Rheumatologists’ perspective on coronavirus disease 19 (COVID-19) and potential therapeutic targets. Current international society recommendations suggest that patients with rheumatic diseases on immunosuppressive therapy should not stop glucocorticoids during COVID-19 infection, although minimum possible doses may be used. 2020-04-11
Management of COVID-19 in patients after liver transplantation: Beijing working party for liver transplantation. It is urgent to set up guidelines for the prevention, diagnosis, and treatment of COVID-19 in liver transplant recipients. 2020-04-11
First case of COVID-19 complicated with fulminant myocarditis: a case report and insights. After receiving antiviral therapy and mechanical life support, Trop I was reduced to 0.10 g/L, and interleukin-6 was reduced to 7.63 pg/mL. 2020-04-11
Feto-placental surgeries during the covid-19 pandemic: starting the discussion. This means that, also during this pandemic, fetal anomalies will be detected, and that discussions regarding invasive genetic testing and possibly fetal therapy will need to take place. 2020-04-11
Novel Coronavirus (SARS-CoV-2) Infection in A Renal Transplant Recipient: Case Report. This case states the importance of close monitoring of the concentration of ciclosporin in patients treated with lopinavir/ritonavir, routine treatment of corticosteroid can be continued. […] Further data are needed to achieve better understanding of the impact of immunosuppressive therapy on the clinical presentation, severity and outcome of SARS-CoV-2 infections in solid organ transplant recipients. 2020-04-11
SAA is a biomarker to distinguish the severity and prognosis of Coronavirus Disease 2019 (COVID-19). Monitoring dynamic changes of SAA, combined with CT imaging could be valuable in diagnosis and treatment of COVID-19. 2020-04-14
Diarrhea during COVID-19 infection: pathogenesis, epidemiology, prevention and management. Current treatment is supportive, but several options appear promising and are the subject of investigation. 2020-04-13
The role and response of palliative care and hospice services in epidemics and pandemics: a rapid review to inform practice during the COVID-19 pandemic. This study aimed to synthesise evidence for the role and response of palliative care and hospice teams to viral epi/pandemics, to inform the COVID-19 pandemic response. 2020-04-13
COVID-19: A promising cure for the global panic. Hence, the recent outburst of COVID-19 highlights an urgent need for therapeutics targeting SARS-CoV-2. […] Further, the current treatment options, drugs available, ongoing trials and recent diagnostics for COVID-19 have been discussed. 2020-04-16
In silico studies on therapeutic agents for COVID-19: Drug repurposing approach. Precautionary measures remain the sole obliging tactic to cease the person to person transmissions till any effective method of treatment or vaccine is developed. […] Along with these, Methisazone an inhibitor of protein synthesis, CGP42112A an angiotensin AT2 receptor agonist and ABT450 an inhibitor of the non-structural protein 3-4A might become convenient treatment option as well against COVID-19. […] The drug repurposing approach provide an insight about the therapeutics that might be helpful in treating corona virus disease. 2020-04-12
The Restructuring of Structural Heart Disease Practice During The Covid-19 Pandemic. The aim of these “crisis-driven” recommendations is (1) to ensure appropriate and timely treatment of SHD patients, (2) to minimize the risk of COVID-19 exposure to patients and healthcare workers, and (3) to limit resource utilization under conditions of constraint. 2020-04-12
Medically-Necessary, Time-Sensitive Procedures: A Scoring System to Ethically and Efficiently Manage Resource Scarcity and Provider Risk During the COVID-19 Pandemic. Surgical treatment of non-COVID-19 related disease during this period, however, still remains necessary. 2020-04-16
COVID-19 and diabetes: Knowledge in progress. We searched for articles in PubMed and Google Scholar databases till 02 April 2020, with the following keywords: “SARS-CoV-2”, “COVID-19”, “infection”, “pathogenesis”, “incubation period”, “transmission”, “clinical features”, “diagnosis”, “treatment”, “diabetes”, with interposition of the Boolean operator “AND”. 2020-04-16
Fighting against COVID-19: Innovative strategies for clinical pharmacists. Clinical pharmacists’ routine task is carrying out pharmaceutical care to ensure patients’ safe and reasonable medication use. […] Facing public health emergencies, clinical pharmacists can give full play to their professional expertise, analyze the current situation rationally, formulate telehealth strategies swiftly, and work in a united and efficient manner to provide innovative pharmacy services to ensure medication safety and rational use of medicine. 2020-04-12
Drug repositioning an alternative for the treatment of coronavirus COVID-19. Given the extreme importance of the current pandemic caused by COVID-19, and due to the fact that scientists agree that there is no identified pharmacological treatment where possible therapeutic alternatives are raised through drug repositioning. […] We present a selection of studies involving drugs from different pharmaceutical classes with activity against SARS-CoV-2 and SARS-Cov, with potential use in the treatment of COVID-19 disease. 2020-04-12
Health-Related-Quality of Life in Common Variable Immunodeficiency Italian patients switched to remote assistance during the COVID-19 pandemic. Since the beginning of COVID-19 epidemic, we shifted all PAD patients to home therapy, and activated remote visits. […] Health-Related-Quality of Life was similar in patients forced to shift from hospital-based to home-based immunoglobulin treatment and in patients who continued their usual home-based replacement. 2020-04-12
COVID-19: Initial experience of an international group of hand surgeons. The emergence of the COVID-19 pandemic has severely affected medical treatment protocols throughout the world. 2020-04-12
Morphological anomalies of circulating blood cells in COVID-19. In patients with COIVD-19, in the early aggravation phase before treatment, observation of peripheral blood film shows the presence of pronounced morhological anomalies of the granulocyte series. […] One week after the start of treatment, such anomalies subside, and an increasing proportion of reactive lymphocytes dominates. 2020-04-12
Threatening drug-drug interaction in a kidney transplant patient with Coronavirus Disease 2019 (COVID-19). During the novel coronavirus pandemic, organ transplant recipients represent a frail susceptible category due to long-term immunosuppressive therapy. […] For this reason, clinical manifestations may differ from general population and different treatment approaches may be needed. […] The patient was left with steroid therapy alone. […] We stress the need for guidelines in transplant recipients with COVID-19 infection with particular regard to the management of therapy. 2020-04-12
Predicting commercially available antiviral drugs that may act on the novel coronavirus (SARS-CoV-2) through a drug-target interaction deep learning model. Due to the lack of effective treatment options for SARS-CoV-2, various strategies are being tested in China, including drug repurposing. […] The result showed that atazanavir, an antiretroviral medication used to treat and prevent the human immunodeficiency virus (HIV), is the best chemical compound, showing an inhibitory potency with Kd of 94.94 nM against the SARS-CoV-2 3C-like proteinase, followed by remdesivir (113.13 nM), efavirenz (199.17 nM), ritonavir (204.05 nM), and dolutegravir (336.91 nM). […] In addition, we also found that several antiviral agents, such as Kaletra (lopinavir/ritonavir), could be used for the treatment of SARS-CoV-2. […] Overall, we suggest that the list of antiviral drugs identified by the MT-DTI model should be considered, when establishing effective treatment strategies for SARS-CoV-2. 2020-04-16
Mesenchymal Stem Cell Therapy for COVID-19: Present or Future. However, no standard treatment for this disease has been discovered to date. […] Probably, preventing the severe acute respiratory infection form of COVID-19 as the most dangerous phase of this disease can be helpful for the treatment and reduction of the death rate. […] In this regard, mesenchymal stem cells (MSCs)-based immunomodulation treatment has been proposed as a suitable therapeutic approach and several clinical trials have begun. […] Given the uncertainties in this area, we reviewed reported clinical trials and hypotheses to provide useful information to researchers and those interested in stem cell therapy. […] In this study, we considered this new approach to improve patient’s immunological responses to COVID-19 using MSCs and discussed the aspects of this proposed treatment. […] However, currently, there are no approved MSC-based approaches for the prevention and/or treatment of COVID-19 patients but clinical trials ongoing. 2020-04-13
Delayed Initiation of Remdesivir in a COVID-19 Positive Patient. A case of late initiation of remdesivir antiviral therapy in the successful treatment of a patient with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in a mixed medical ICU of a community teaching hospital is presented. 2020-04-13
Performance of Electrophysiology Procedures at an Academic Medical Center Amidst the 2020 Coronavirus (COVID-19) Pandemic. Aside from the pulmonary manifestations of disease, there are likely to be several electrophysiologic (EP) sequelae of COVID-19 infection and its treatment, due to consequences of myocarditis and the use of QT-prolonging drugs. 2020-04-13
Use of Convalescent Plasma Therapy in Two COVID-19 Patients with Acute Respiratory Distress Syndrome in Korea. Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus-2 not yet has established its treatment, but convalescent plasma has been expected to increase survival rates as in the case with other emerging viral infections. […] To our knowledge, this is the first report of the use of convalescent plasma therapy for COVID-19 in Korea. 2020-04-15
[Rapid establishment of traditional Chinese medicine prevention and treatment of 2019-nCoV based on clinical experience and molecular docking]. Currently, there is no specific drug or vaccine besides symptomatic supportive therapy. […] In view of the high homology between the gene sequences of the novel coronavirus and SARS virus, and the similarities between the two in terms of pathogenic mechanism and clinical manifestations, our team established a rapid screening and optimization model for the prevention and treatment of the novel coronavirus based on clinical experience and molecular docking technology. […] This provides evidence for the scientific and potential efficacy of the TCM prescription from the perspective of treatment target analysis, and also suggests that the TCM prescription has the potential to directly inhibit viral infection in addition to improving clinical symptoms or syndromes. […] Based on this, our team optimized and formed a new anti-coronavirus TCM prescription &quot;Keguan Yihao&quot;, immediately providing the TCM prescription with certain clinical experience and objective evidence support for the prevention and treatment of new emergent infectious diseases in our hospital. […] The TCM prescription was combined with modern medicine symptomatic supportive treatment for clinical treatment, preliminary results showed better effect than symptomatic supportive therapy alone. 2020-04-14
[Study on screening potential traditional Chinese medicines against 2019-nCoV based on Mpro and PLP]. This study established optimization docking models and virtual screening to discovery potential active herbs for the prevention and treatment of the novel coronavirus based on molecular docking technology. […] By combining the diagnosis and treatment scheme of Hunan province’s and angiotensin converting enzyme 2(ACE2) inhibitors screening from literature, present study also discussed the rational application of candidate herbs to this epidemic situation. 2020-04-14
[Study on treatment of “cytokine storm” by anti-2019-nCoV prescriptions based on arachidonic acid metabolic pathway]. In the end, we obtained the potential active prescriptions on &quot;cytokine storm&quot; according to the potential herbs in the &quot;National novel coronavirus pneumonia diagnosis and treatment plan(trial version sixth)&quot;. 2020-04-14
[Analysis on clinical study protocols of traditional Chinese medicine for coronavirus disease 2019]. To analyze the registered clinical trial protocols of traditional Chinese medicine(TCM) for the prevention and treatment of coronavirus disease 2019(COVID-19), in order to provide information for improving the quality of research design. […] There was a quick response of clinical research on the prevention and treatment of COVID-19 with TCM, with the current registered protocols covers the whole process of disease prevention, treatment and rehabilitation. 2020-04-14
[Analysis on pattern of prescriptions and syndromes of traditional Chinese medicine for prevention and treatment of COVID-19]. To investigate the regularity of prescription and clinical syndromes by analyzing the diagnosis and treatment protocols of traditional Chinese medicine(TCM) for coronavirus disease 2019(COVID-19), so as to provide references for syndrome differentiation and relevant researches. […] The diagnosis and treatment protocols of COVID-19 published by national and regional health authorities were searched, and information was extracted in regard to disease stages, type of syndromes, and prescriptions, etc. […] A total of 26 diagnosis and treatment protocols of TCM for COVID-19 were retrieved after screening(including 1 national scheme and 25 regional ones), among which 16 contained aspects of both prevention and treatment, 7 only involved treatment contents and 3 were prevention schemes. […] There were many diagnosis and treatment protocols for COVID-19 have been published, which generally followed the national edition, through with certain personalities in different regional protocols. […] There were common features with respect to the disease stage, syndrome differentiation, therapeutic principles and methods, as well as prescriptions; the treatment were generally carried out against the core pathogenesis and progress of the disease. […] Along with the deepening recognition of COVID-19, the diagnosis and treatment protocols are still need further concretization and standardization. […] We hope researchers and decision-makers can pay more attention to the treatment of Huayu Tongluo in severe and recovery period. 2020-04-14
[Study on medication regularity of traditional Chinese medicine in treatment of COVID-19 based on data mining]. From the medicinal properties to high-frequency drugs and new prescriptions, it could be seen that the overall treatment of COVID-19 by traditional Chinese medicine was to strengthen body resistance, eliminate pathogenic factors, and give attention to Qi and Yin. 2020-04-14
[Analysis of property and efficacy of traditional Chinese medicine in staging revention and treatment of coronavirus disease 2019]. This study collected prevention and treatment approaches of traditional Chinese medicine for COVID-19 released from the National Health Committee of China, 7 provinces and municipal health committees, the Chinese Medicine Administration and Handbook of Traditional Chinese Medicine Diagnosis and Treatment of COVID-19 between January 1 and February 18, 2020, and prescriptions prepared by 3 masters of Chinese medicine and 4 well-known Chinese medicine experts. […] These information were selected according to the inclusion and exclusion criteria, and EpiData 3.0 software was used to establish the &quot;Traditional Chinese Medicine Prescription Library for the Prevention and Treatment of COVID-19&quot; and the &quot;Common Database of Traditional Chinese Medicine for the Prevention and Treatment of COVID-19&quot;. […] Staged medication and local conditions need attention during the identification and treatment of COVID-19 clinical syndromes. 2020-04-14
[Strategy of pharmaceutical care services for clinical Chinese pharmacists in coronavirus disease 2019 (COVID-19)]. Traditional Chinese medicine(TCM) has been recommended for the treatment of COVID-19 in Novel Coronavirus Pneumonia Prevention and Control Strategy, which have made outstanding contributions to the prevention and control of the epidemic. […] The wide application of Chinese medicine asked the pharmacists and doctors, nurses, and medical technicians in Wuhan and around the country to stand on the front line of COVID-19 treatment, and provide pharmaceutical care services, which has effectively guaranteed the safety and rational use of Chinese medicine. […] This article will introduce the TCM cognition of the COVID-19, analyze the clinical application of Chinese medicine and the entry point of pharmaceutical care, and clarify that clinical Chinese pharmacists can participate in making medication therapy plan, medication reconciliation, and prescription review, promoting rational drug use, pharmaceutical monitoring, and drug risk management. […] The participation of clinical Chinese pharmacists in the prevention and treatment of COVID-19 is conducive to improving the level of rational use of TCM, by ensuring the effectiveness, and safety. 2020-04-14
[Research progress of intervention of Chinese herbal medicine and its active components on human coronavirus]. However, there have not been any effective drugs for treatment, with symptomatic treatment and prevention prevailing. […] The treatment plans of severe acute respiratory syndrome(SARS) and Middle East respiratory syndrome(MERS) are often used for reference in clinic. […] The advantages of traditional Chinese medicine(TCM) in treating SARS and MERS are that it can intervene and block the progression of disease in early stage, significantly reduce symptoms, shorten the treatment duration of patients, reduce complications and side effects caused by hormone therapy. […] Chinese patent medicines and prescriptions in medical observation and clinical treatment were recommended in the &quot;pneumonia diagnosis and treatment plan for new coronavirus infection&quot;(trial version fifth) of the National Health Commission of the People’s Republic of China. […] Qingfei Paidu Decotion was recommended for the treatment of COVID-19 by the National Health Commission of the People’s Republic of China and National Administration of Traditional Chinese Medicine. […] TCM shows good clinical efficacy and great potential in the treatment of COVID-19. […] In this paper, we reviewed traditional Chinese medicines and its active ingredients in the hope of bringing novel inspirations to the drug screening and clinical treatment for COVID-19. 2020-04-14
Challenges and cares to promote rational use of chloroquine and hydroxychloroquine in the management of coronavirus disease 2019 (COVID-19) pandemic: a timely review. This study provides information on the main toxicological and epidemiological aspects to be considered for prophylaxis or treatment of COVID-19 using CQ but mainly HCQ, which is a less toxic derivative than CQ, and was shown to produce better results in inhibiting proliferation of SARS-CoV-2 based upon preliminary tests. 2020-04-16
Coronavirus disease 2019: new things to know! " 1 which report the clinical features, diagnosis and treatment of the novel Coronavirus Disease 2019 (COVID-19). 2020-04-13
COVID-19 indirect contact transmission through the oral mucosa must not be ignored. Mucosa exposure and inappropriate treatment of medical and non-medical articles used by the patients all could increase the risks of COVID-19 transmission. 2020-04-13
Existing bitter medicines for fighting 2019-nCoV-associated infectious diseases. Based on the idea of host-directed therapy (HDT), we performed a negative co-expression analysis using big data of 60 000 Affymetrix expression arrays and 5000 TCGA data sets to determine the functions of TAS2R10, which can be activated by numerous bitter substances. […] To quickly guide the clinical treatment of 2019-nCoV, we searched currently available drugs that are agonists of TAS2Rs. 2020-04-13
[Covid-19 in patients on dialysis: infection prevention and control strategies]. However, as Covid-19 is an emerging disease, more work is needed to improve prevention, diagnosis and treatment strategies. […] It is essential to avoid nosocomial spread; in order to control and reduce the rate of infections it is necessary to strengthen the management of medical and nursing personnel through the early diagnosis, isolation and treatment of patients undergoing dialysis treatment. […] We cover here a series of recommendations for the treatment of dialysis patients who are negative to the virus, and of those who are suspected or confirmed positive. 2020-04-16
Pharmacologic Treatments for Coronavirus Disease 2019 (COVID-19): A Review. The pandemic of coronavirus disease 2019 (COVID-19) caused by the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) presents an unprecedented challenge to identify effective drugs for prevention and treatment. […] The most promising therapy is remdesivir. 2020-04-13
Rehabilitation following critical illness in people with COVID-19 infection. Large numbers of people are predicted to become critically ill with acute respiratory distress syndrome (ARDS) and will require management in intensive care units (ICUs). 2020-04-13
Innovation in Response to the COVID-19 Pandemic Crisis. Here he considers the implications of exemplary innovations-virtual care, hospital at home, advances in diagnosis and therapy, virtual learning, and virtual clinical learning-for regulators, academic medical centers, faculty, and students. 2020-04-13
Cardiovascular Considerations in Treating Patients with Coronavirus (COVID-19). No established treatment is currently available; however, several therapies, including remdesivir, hydroxychloroquine and chloroquine, and interleukin (IL)-6 inhibitors, are being used off-label and evaluated in ongoing clinical trials. 2020-04-13
Anesthetic Management of Endovascular Treatment of Acute Ischemic Stroke During COVID-19 Pandemic: Consensus Statement from Society for Neuroscience in Anesthesiology & Critical Care (SNACC)_Endorsed by Society of Vascular & Interventional Neurology (SVIN), Society of NeuroInterventional Surgery (SNIS), Neurocritical Care Society (NCS), and European Society of Minimally Invasive Neurological Therapy (ESMINT). The pandemic of coronavirus disease 2019 (COVID-19) has unique implications for the anesthetic management of endovascular therapy for acute ischemic stroke. […] The Society for Neuroscience in Anesthesiology and Critical Care appointed a task force to provide timely, consensus-based expert recommendations using available evidence for the safe and effective anesthetic management of endovascular therapy for acute ischemic stroke during the COVID-19 pandemic. 2020-04-13
Molecular immune pathogenesis and diagnosis of COVID-19. In this minireview, we provide a brief introduction of the general features of SARS-CoV-2 and discuss current knowledge of molecular immune pathogenesis, diagnosis and treatment of COVID-19 on the base of the present understanding of SARS-CoV and MERS-CoV infections, which may be helpful in offering novel insights and potential therapeutic targets for combating the SARS-CoV-2 infection. 2020-04-16
Latin American healthcare systems in times of pandemic. State-run hospitals and clinics are already overstressed by continuous demand for treatment of vector-borne diseases and community-acquired infections as well as high rates of non-communicable diseases. […] As ethical expertise in Latin America focuses on research ethics, few hospitals in the region have functioning clinical ethics committees or clinical ethics policy, forcing healthcare personnel to make excruciating treatment decisions in an environment dominated by material scarcity and public distrust. 2020-04-14
Clinical characteristics and immunosuppressants management of coronavirus disease 2019 in solid organ transplant recipients. Following a treatment regimen consisting of discontinued immunosuppressant use and low-dose methylprednisolone-based therapy, the patient developed acute rejection but eventually recovered. […] His treatment regimen consisted of reduced immunosuppressant use. 2020-04-13
Immunosuppressive therapy maintenance in a kidney transplant recipient SARS-CoV-2 pneumonia: a case report. We report a case of a 32-year-old KTR who developed SARS-CoV-2 infection and fully recovered in 15 days while maintaining standard immunosuppressive therapy. 2020-04-13
DOACs and ‘newer’ haemophilia therapies in COVID-19. We would like to thank the authors for their insightful thoughts on the consideration of anticoagulants and treatment for haemophilia A and B during the COVID-19 pandemic. 2020-04-13
Remdesivir and SARS-CoV-2: structural requirements at both nsp12 RdRp and nsp14 Exonuclease active-sites. Viral RNA-dependent RNA polymerases (RdRp) play essential roles in viral RNA synthesis, and thus remains the target of choice for the prophylactic or curative treatment of several viral diseases, due to high sequence and structural conservation. […] To date, the most promising broad-spectrum class of viral RdRp inhibitors are nucleoside analogues (NAs), with over 25 approved for the treatment of several medically important viral diseases. 2020-04-16
Arbidol Monotherapy is Superior to Lopinavir/ritonavir in Treating COVID-19. The cycle threshold values of open reading frame 1ab and nucleocapsid genes by RT-PCR assay were monitored during antiviral therapy. 2020-04-13
The effect of corticosteroid treatment on patients with coronavirus infection: a systematic review and meta-analysis. An outbreak of novel coronavirus in 2019 threatens the health of people, and there is no proven pharmacological treatment. […] The result indicated that critical patients were more likely to require corticosteroids therapy (risk ratio [RR]=1.56, 95% confidence interval [CI]=1.28-1.90, P<0.001). […] However, corticosteroid treatment was associated with higher mortality (RR=2.11, 95%CI=1.13-3.94, P=0.019), longer length of stay (weighted mean difference [WMD]=6.31, 95%CI=5.26-7.37, P<0.001), a higher rate of bacterial infection (RR=2.08, 95%CI=1.54-2.81, P<0.001), and hypokalemia (RR=2.21, 95%CI=1.07-4.55, P=0.032) but not hyperglycemia (RR=1.37, 95%CI=0.68-2.76, P=0.376) or hypocalcemia (RR=1.35, 95%CI=0.77-2.37, P=0.302). 2020-04-13
Cytokine Storm in COVID-19 and Treatment. This article reviews the occurrence mechanism and treatment strategies of the COVID-19 virus-induced inflammatory storm in attempt to provide valuable medication guidance for clinical treatment. 2020-04-13
Graft cryopreservation does not impact overall survival allogeneic hematopoietic cell transplantation using post-transplant cyclophosphamide for GVHD prophylaxis. There were somewhat lower rates chronic GVHD (HR=0.78, 0.61-0.99, p=0.04) and DFS (HR for treatment failure=1.19, 95%CI=1.01-1.29, p=0.04) with graft cryopreservation that were of marginal statistical significance after adjusting for multiple comparisons. 2020-04-13
Mortality of a pregnant patient diagnosed with COVID-19: A case report with clinical, radiological, and histopathological findings. The first chest X-ray (faint bilateral patchy opacities) and CT scan (some faint subpleural ground-glass opacities associated with pleural thickening) were not typical for initial COVID-19 pulmonary infection, however, the treatment for COVID-19 was started. 2020-04-16
Rapid Implementation of Inpatient Telepalliative Medicine Consultations during COVID-19 Pandemic. As COVID-19 cases increase throughout the country and healthcare systems grapple with the need to decrease provider exposure and minimize personal protective equipment (PPE) use while maintaining high quality patient care, our specialty is called upon to consider new methods of delivering inpatient palliative care. […] Telepalliative medicine has been used to great effect in outpatient and home-based palliative care, but has had fewer applications in the inpatient setting. […] We describe our rapid and ongoing implementation of telepalliative medicine consultation for our inpatient palliative care teams and discuss lessons learned and recommendations for programs considering similar care models. 2020-04-16
COVID-19 - Considerations for the paediatric rheumatologist. Since severe complications in adults are frequently caused by uncontrolled immune responses and a resulting “cytokine storm” that may be controlled by targeted blockade of cytokines, previously established treatment with immunosuppressive treatments may indeed protect children from complications. 2020-04-16
Clinical Features of COVID-19-Related Liver Damage. We aimed to clarify the features of COVID-19-related liver damage to provide references for clinical treatment. 2020-04-13
Mesenchymal Stromal Cell Secretome for Severe COVID-19 Infections: Premises for the Therapeutic Use. At the moment, there is no specific antiviral treatment recommended for the COVID-19 pandemic and the therapeutic strategies to deal with the infection are only supportive. 2020-04-15
Novel ionophores active against La Crosse virus identified through rapid antiviral screening. In sum, we demonstrate the importance of potassium ions to virus infection, suggesting a potential therapeutic target to disrupt virus replication.Importance No antivirals are approved for the treatment of bunyavirus infection. 2020-04-14
Coronavirus Disease 2019 Treatment: A Review of Early and Emerging Options. On behalf of the Society of Infectious Diseases Pharmacists, we herein summarize the current evidence as of March 18, 2020 to provide guidance on potential COVID-19 treatment options. […] It is important to caution readers that new data emerges daily regarding clinical characteristics, treatment options, and outcomes for COVID-19. […] Optimized supportive care remains the mainstay of therapy, and the clinical efficacy for the subsequent agents is still under investigation. 2020-04-16
Searching therapeutic strategy of new coronavirus pneumonia from angiotensin-converting enzyme 2: the target of COVID-19 and SARS-CoV. This article will summarize the role of ACE2 in multiple organ damage caused by COVID-19 and SARS-CoV, targeted blocking drugs against ACE2, and drugs that inhibit inflammation in order to provide the basis for subsequent related research, diagnosis and treatment, and drug development. 2020-04-14
What Is the Appropriate Use of Laparoscopy over Open Procedures in the Current COVID-19 Climate? Few studies have been performed on viral transmission during surgery, but to date there is no study that demonstrates or can suggest the ability for a virus to be transmitted during surgical treatment whether open or laparoscopic. 2020-04-14
A framework for open tracheostomy in COVID-19 patients. Intensive care units are facing a surge of patients requiring invasive ventilation.It is likely that requests for a tracheostomy in COVID-19 ventilated patients will soon come our way. 2020-04-14
Optimizing hydroxychloroquine dosing for patients with COVID-19: An integrative modeling approach for effective drug repurposing. Hydroxychloroquine (HCQ) is a promising candidate for Coronavirus Disease of 2019 (COVID-19) treatment. […] Our goal was to integrate historic and emerging pharmacological and toxicity data to understand safe and efficacious HCQ dosing strategies for COVID-19 treatment. […] HCQ doses > 400 mg BID for ≥5 days were predicted to rapidly decrease viral loads, reduce the proportion of patients with detectable SARS-CoV-2 infection, and shorten treatment courses, compared to lower dose (≤400 mg daily) regimens. 2020-04-14
Computed Tomography Imaging of an HIV-infected Patient with Coronavirus Disease 2019 (COVID-19). Chest computed tomography (CT) showed different abnormalities from those of conventional COVID-19, and the faster absorption of pulmonary lesions also highlights the importance of antiretroviral therapy in this patient. […] This report provides reference for the diagnosis and treatment of HIV-infected patients with COVID-19. 2020-04-14
COVID-19 challenge for modern medicine. A significant number of patients with pneumonia require passive oxygen therapy. […] Non-invasive ventilation and high-flow nasal oxygen therapy can be applied in mild and moderate non-hypercapnia cases. […] Specific pharmacological treatment for COVID-19 is not currently available. […] The key is a holistic approach to the patient including, primarily, the use of personal protective equipment to reduce the risk of further virus transmission, as well as patient management, which consists in both quarantine and, in the absence of specific pharmacological therapy, symptomatic treatment. 2020-04-14
Novel 2019 coronavirus SARS-CoV-2 (COVID-19): an overview for emergency clinicians. This review analyzes information from worldwide research and experience on the epidemiology, prevention, and treatment of COVID-19, and offers links to the most reliable and trustworthy resources to help equip healthcare professionals in managing this public health challenge. 2020-04-14
Computational Design of ACE2-Based Peptide Inhibitors of SARS-CoV-2. The proposed peptide inhibitors could provide simple and efficient therapeutics against the COVID-19 disease. 2020-04-16
COVID-19 Pandemic: Experiences in China and implications for its prevention and treatment worldwide. This pandemic emphasizes the need to be constantly alert to shifts in both the global dynamics and the contexts of individual countries, making sure that all are aware of which approaches are successful for the prevention, containment and treatment of new diseases, and being flexible enough to adapt the responses accordingly. 2020-04-14
Clinical Characteristics of COVID-19 Patients With Digestive Symptoms in Hubei, China: A Descriptive, Cross-Sectional, Multicenter Study. All patients were confirmed by real-time polymerase chain reaction and were analyzed for clinical characteristics, laboratory data, and treatment. […] Patients with digestive symptoms had higher mean liver enzyme levels, lower monocyte count, longer prothrombin time, and received more antimicrobial treatment than those without digestive symptoms. 2020-04-14
Demand Analysis and Management Suggestion: Sharing Epidemiological Data Among Medical Institutions in Megacities for Epidemic Prevention and Control. Following Law of the People’s Republic of China on Prevention and Treatment of Infectious Diseases and other related regulations, medical institutions have been authorized to collect the detailed information of patients, while it is still a formidable task in megacities because of the significant patient mobility and the existing information sharing barrier. 2020-04-16
Herbal medicine and pattern identification for treating COVID-19: a rapid review of guidelines. We searched 7 data sources for eligible traditional medicine guidelines up to March 6, 2020 and found a total of 28 traditional medicine guidelines that provide treatment measures for COVID-19. […] This review can be used as guidance for the traditional medicine treatment of COVID-19. 2020-04-16
Collaborative Multi-Disciplinary Incident Command at Seattle Children’s Hospital for Rapid Preparatory Pediatric Surgery Countermeasures to the COVID-19 Pandemic. Although the treatment and protective standards are continuously evolving, this commentary shares our thoughts on how an institution, specifically surgical services may develop collaborative process improvement to accommodate for rapid and ongoing change. 2020-04-16
Evidence Based Management Guideline for the COVID-19 Pandemic - Review article. Management is predominantly focused on the provision of supportive care, with oxygen therapy representing the major treatment intervention. […] Medical therapy involving corticosteroids and antivirals have also been encouraged as part of critical management schemes. […] However, there is at present no specific antiviral recommended for the treatment of COVID-19, and no vaccine is currently available. 2020-04-16
Clinical and microbiological effect of a combination of hydroxychloroquine and azithromycin in 80 COVID-19 patients with at least a six-day follow up: A pilot observational study. We need an effective treatment to cure COVID-19 patients and to decrease virus carriage duration. […] Furthermore, the cost of treatment is negligible. 2020-04-16
Epidemiological and clinical features of 125 Hospitalized Patients with COVID-19 in Fuyang, Anhui, China. All patients were given antiviral therapy. 2020-04-16
A Rational Use of Clozapine Based on Adverse Drug Reactions, Pharmacokinetics, and Clinical Pharmacopsychology. Using Richardson and Davidson’s model and the sciences of pharmacokinetics and clinical pharmacopsychology, this article reviewed the: (1) poor life expectancy associated with treatment-resistant schizophrenia (TRS), which may be improved in patients who adhere to clozapine; (2) findings that clozapine is the best treatment for TRS (according to efficacy, effectiveness and well-being); and (3) potential for clozapine to cause vulnerabilities, including potentially lethal adverse drug reactions such as agranulocytosis, pneumonia, and myocarditis. 2020-04-14
A Review of SARS-CoV-2 and the Ongoing Clinical Trials. Although our understanding of coronaviruses has undergone a huge leap after two precedents, the effective approaches to treatment and epidemiological control are still lacking. 2020-04-16
Experience summary of a COVID-19 designated community hospital and its operation model. To summarize the administration model of a COVID-19 designated hospital transformed from a community hospital to improve the emergency capacity of community hospitals and the efficiency of diagnosis and treatment of medical staff in the COVID-19 pandemic. […] Analyze the surrounding environment, ward layout, area management, treatment process, medical staff and patient management of the designated community hospital. […] Its diagnosis and treatment model has completed the treatment of COVID- 19 patients successfully. […] After adjustment, this community hospital can shoulder the critical task of being a designated hospital for COVID-19, which includes admission, isolation, and therapy of suspected and mild COVID-19 patients, reducing the medical burden of superior hospitals. 2020-04-15
Do checkpoint inhibitors compromise the cancer patients’ immunity and increase the vulnerability to COVID-19 infection? Cancer patients represent a vulnerable population due to the acquired immunodeficiency associated with anti-cancer therapy. 2020-04-15
Why tocilizumab could be an effective treatment for severe COVID-19? Moreover, Tocilizumab treatment that blocking IL-6 receptors showed inspiring clinical results including temperature returned to normal quickly and respiratory function improved. […] Therefore, we suggest that Tocilizumab is an effective treatment in severe patients of COVID-19 to calm the inflammatory storm and reduce mortality. 2020-04-16
EZH2-mediated H3K27me3 inhibits ACE2 expression. Our discovery provides clues for pathogenesis and targeted drug therapy towards ACE2 expression for prevention and adjuvant therapy of COVID-19. 2020-04-15
Ongoing Clinical Trials for the Management of the COVID-19 Pandemic. Here, we review currently registered interventional clinical trials for the treatment and prevention of COVID-19 to provide an overall summary and insight into the global response. 2020-04-15
German recommendations for critically ill patients with COVID‑19. However, about 5% become critically ill and require intensive care treatment. […] To date there is no specific treatment available-the main goal of supportive therapy is to ascertain adequate oxygenation. 2020-04-15
Outcomes in Patients with COVID-19 Infection Taking ACEI/ARB. This editorial presents the available evidence to guide treatment practices during this pandemic. 2020-04-16
The epidemiology and clinical information about COVID-19. In this review, we summarized the epidemiological characteristics, clinical features, diagnosis, treatment, and prognosis of COVID-19. 2020-04-15
Reply to the comment. Thus they suggested the anticoagulant treatment in patients with coronavirus disease 2019 (COVID-19). 2020-04-15
Recommendations of individualized medical treatment and common adverse events management for lung cancer patients during the outbreak of COVID-19 epidemic. Patients with cancer are more likely than the general population to contract COVID-19 because of the systemic immunosuppressive status caused by malignant diseases or anticancer treatment. […] Most patients with lung cancer are smokers with poor underlying lung conditions and low immunity, thus it is vital to protect them from epidemic diseases during cancer treatment. […] It is necessary to provide individualized medical treatment and management of treatment-related adverse events for patients with lung cancer based on patients’ conditions and regional epidemic patterns. 2020-04-15
[Application of tracheotomy in the treatment of severe cases of COVID-19]. Objective: Todiscuss the the effects, indications and protective measures of tracheotomy for severe cases of 2019 novel corona virus disease(COVID-19)patients. Methods: A retrospectively analyze was conducted to explore the clinical data of ofCOVID-19 patients who received tracheotomy in February to March 2020,descriptive statistics were used to analyze the indication of tracheotomy, particularity of intraoperative treatment and protective measures. Results: A total of 4 cases were included in this article, 3 cases were successfully operated, 1 case of postoperative incision continuous bleeding, there were not other complications and nosocomial infection among the medical staff.the patient’s condition was relieved in different degrees after the operation, who remain hospitalized. Conclusion: Tracheotomy for severe cases of COVID-19 can achieve certain curative effect, but the occurrence of tracheotomy related complicationsand nosocomial infection should be effectively controlled, and the risk benefit ratio of tracheotomy should be carefully weighed before surgery. 目的: 探讨新型冠状病毒肺炎危重型患者施行气管切开术的指征、术中处理的特殊性及防护措施。 2020-04-15
Stem cell-based therapy for coronavirus disease 2019. In this commentary, we offer an alternative promising therapy for COVID-19, that is, mesenchymal stem cells (MSCs) transplantation. 2020-04-15
[Distributions of time, place, and population of novel coronavirus disease 2019 (COVID-19) from January 20 to February 10, 2020, in China]. The COVID-19 epidemic should be considered a global threat and the steps for control include early diagnosis and treatment, as well as isolation. 2020-04-15
Guidelines for dental care provision during the COVID-19 pandemic. Several dental care facilities in affected countries have been completely closed or have been only providing minimal treatment for emergency cases. […] However, several facilities in some affected countries are still providing regular dental treatment. 2020-04-15
CT Scans of Patients with 2019 Novel Coronavirus (COVID-19) Pneumonia. Three kinds of responses to clinical treatment were defined and evaluated: 1) good, symptoms continually improved; 2) fair, symptoms not improved or relapsed; 3) poor, symptoms aggravated. […] The progression in abnormal imaging findings indicate a poor/fair response, whereas the alleviated symptoms seen from CT suggest a good response. Conclusion: Most cases are no-emergency type and have a favorable response to clinical treatment. […] Follow-up CT changes during the treatment can help evaluate the treatment response of patients with NCP. 2020-04-16
Highlights of traditional Chinese medicine frontline expert advice in the China national guideline for COVID-19. As the epicentre of the initial outbreak, China has been updating the National COVID-19 Diagnostic and Treatment Guideline with up-to-date information about the disease. 2020-04-15
Mutated COVID-19, May Foretells Mankind in a Great Risk in the Future. Our study aimed to present an overview of the virus in terms of structure, epidemiology, symptoms, treatment, and prevention. 2020-04-15
Clinical study of mesenchymal stem cell treating acute respiratory distress syndrome induced by epidemic Influenza A (H7N9) infection, a hint for COVID-19 treatment. Collectively, these results suggest that MSCs significantly improve survival rate of H7N9 induced ARDS and provide a theoretical basis for the treatment of H7N9 induced ARDS in both preclinical research and clinical studies. […] Because H7N9 and the corona virus disease 2019 (COVID-19) share similar complications (such as ARDS and lung failure) and corresponding multi-organ dysfunction, MSC-based therapy could be a possible alternative for treating COVID-19. 2020-04-15
Emergency management of nursing human resources and supplies to respond to coronavirus disease 2019 epidemic. By taking these strategies, the hospital effectively improved the coping capacity of the nursing team and played a positive role in the prevention and treatment of COVID-19. 2020-04-15
Holistic care for patients with severe coronavirus disease 2019: An expert consensus. This consensus included nursing assessment, nursing priorities, nursing goals, and thirteen key points of nursing procedures such as nursing of oxygen therapy and respiratory nursing. 2020-04-15
Contingency management strategies of the Nursing Department in centralized rescue of patients with coronavirus disease 2019. This article aims to summarize a series of contingency management strategies of the Nursing Department in the centralized treatment of patients with coronavirus disease 2019(COVID-19). […] The strategies of the Nursing Department included early warning for prevention and control, taking functions of vertically commanding and horizontally coordinating, and reasonably allocating nursing workforce, to facilitate centralized treatment work in the in-hospital fever clinic, isolation wards and ICU, and referral and admission of critical patients. […] Through the implementation of these strategies, safe and efficient centralized treatment was ensured timely, orderly and sustainably. 2020-04-15
Coronavirus: Update Related to the Current Outbreak of COVID-19. To date, there is no specific therapy for COVID-19. 2020-04-15
Determining the spatial effects of COVID-19 using the spatial panel data model. Using spatial panel models, we analyse the relationship between confirmed cases of COVID-19, deaths thereof, and recovered cases due to treatment. 2020-04-15
Adapting palliative radiation therapy for bone metastases during the Covid-19 pandemic: GEMO position paper. The current health crisis caused by COVID-19 is a challenge for oncology treatment, especially when it comes to radiotherapy. […] In order to treat patients safely while protecting medical teams, the entire health care system must optimize the way it approaches prevention and treatment at a time when social distancing is key to stemming this pandemic. […] All indications and treatment modalities must be re-discussed. […] In this short piece, the members of the GEMO (the European Study Group of Bone Metastases) offer a number of recommendations to achieve the above objectives, both in general and in relation to five of the most common situations on radiation therapy for bone metastases. 2020-04-15
Chinese herbal Huo-Gu Formula for treatment of steroid-associated osteonecrosis of femoral head: a 14-years follow-up of convalescent SARS patients. Osteonecrosis of the femoral head (ONFH) is a common disabling complication among convalescent SARS patients who received corticosteroid therapy. […] In China, a considerable number of convalescent SARS patients with steroid-associated ONFH had undergone conservative treatment by Traditional Chinese Medicine (TCM), and this study aims to evaluate the long-term results of a spleen-invigorating Huo-Gu Formula (HGF) therapy in these patients. and methods: A total of 33 convalescent SARS patients (nine males and 24 females) with bilateral steroid-associated ONFH (66 hips) were enrolled in this study. […] All patients received oral HGF therapy for six months when they were confirmed the diagnosis of steroid-associated ONFH. […] Based on average 14 years of follow-up of HGF therapy (ranging from six to 16 years), 38 hips (57%) among the 66 hips developed definite osteoarthritis, and 14 hips (26%) in 53 pre-collapse hips (ARCO stage I or II) progressed to femoral head collapse(ARCO stage III or IV). […] Chinese herbal HGF therapy demonstrates beneficial effects on preventing femoral head collapse, delaying total hip arthroplasty (THA)surgery, and maintaining physical function in the treatment of steroid-associated ONFH. […] HGF therapy might be therefore a good alternative for the treatment of steroid-associated ONFH secondary to rheumatologic and infection diseases. 2020-04-15
Emergence of deadly severe acute respiratory syndrome coronavirus-2 during 2019-2020. In addition we have also provided information about transmission dynamics, prevention measures and treatment options that are available at the present. […] Joint efforts of global scientific community are needed at this hour in terms of enhancement of research on development of accurate diagnostics, antiviral therapeutics and finally into formation of an effective vaccine against the emerging novel coronavirus. 2020-04-15
Data on the stability of darunavir/cobicistat suspension after tablet manipulation. Unfortunately, for most of them, the drug products available on the market are not designed to be administered by a nasogastric tube to inpatients of intensive care units. 2020-04-15
Coalition: Advocacy for prospective clinical trials to test the post-exposure potential of hydroxychloroquine against COVID-19. We have studied its use as an antimalarial, an antiviral, and an immunomodulating drug and concluded that the use of HCQ at does matching that of the standard treatment of Systemic Lupus erythematous, which has proven safety and efficacy in terms of HCQ blood and tissue concentration adapted to bodyweight (2,3), at 6 mg/kg/day 1 (loading dose) followed by 5 mg/kg/day, with a maximum limit of 600 mg/day in all cases should swiftly be clinically evaluated as a post-exposure drug for exposed people. 2020-04-15
A living systematic review protocol for COVID-19 clinical trial registrations. While there is no intervention for the prevention or treatment of COVID-19 with proven clinical efficacy to date, tools to distil the current research landscape by intervention, level of evidence and those studies likely powered to address future research questions is essential. 2020-04-15
Prostate Cancer Radiotherapy Recommendations in Response to COVID-19. During a global pandemic the benefit of routine visits and treatment of cancer patients must be weighed against the risks to patients, staff, and society. […] Treatment can be avoided or delayed until safe for very low, low, and favorable intermediate-risk disease. […] Unfavorable intermediate-risk, high-risk, clinical node positive, recurrence post-surgery, oligometastatic, and low-volume M1 disease can receive neoadjuvant hormone therapy for 4-6 months as necessary. 2020-04-15
The Heart in COVID19: Primary Target or Secondary Bystander? Dealing with the immense challenge of COVID-19 disease, confronted with severely ill patients in dire straits with virtually no rigorous evidence base to guide our therapy, we must call upon our clinical skills and judgment. […] Lacking a robust evidence base, pathophysiologic reasoning can help guide our choices of therapy for individual clinical scenarios. 2020-04-15
COVID-19 for the Cardiologist: A Current Review of the Virology, Clinical Epidemiology, Cardiac and Other Clinical Manifestations and Potential Therapeutic Strategies. We review the most current data with a focus on our basic understanding of the mechanism(s) of disease and translation to the clinical syndrome and potential therapeutics. 2020-04-15
Management Of Patients On Dialysis And With Kidney Transplant During SARS-COV-2 (COVID-19) Pandemic In Brescia, Italy. During the first phase of the disease (from onset of the symptoms up to 7-10 days) viral-induced effects are prominent with the opportunity to institute antiviral therapy. 2020-04-15
Coronavirus Disease 2019 (COVID-19) Pneumonia in a Hemodialysis Patient. The diagnosis, infection control, and treatment of COVID-19 in hemodialysis patients are discussed in this report, and we conclude with recommendations for how a dialysis facility can respond to COVID-19 based on our experiences. 2020-04-15
Target Virus or Target Ourselves for COVID-19 Drugs Discovery?-Lessons learned from anti-influenzas virus therapies. For this emergency, the FDA has approved Remdesivir and Hydroxychloroquine for treatment of COVID-19 as Emergency Use Authorization. 2020-04-15
Exploring Personal Protection During High-Risk PCI in a COVID-19 Patient: Impella CP Mechanical Support During ULMCA Bifurcation Stenting. We describe the percutaneous treatment of an unprotected left main coronary artery in a patient who is positive for coronavirus disease 2019 with unstable angina, dyspnea and fever. 2020-04-15
Hypertension, the renin-angiotensin system, and` the risk of lower respiratory tract infections and lung injury: implications for COVID-19. This raised multiple questions regarding a more severe course of COVID-19 in relation to hypertension itself as well as its treatment with renin-angiotensin system (RAS) blockers, e.g. angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin receptor blockers (ARBs). […] We also review in detail the molecular mechanisms linking the RAS to lung damage and the potential clinical impact of treatment with RAS blockers in patients with COVID-19 and a high cardiovascular and renal risk. 2020-04-15
[Palliation in patients with severe COVID-19]. Symptomatic (palliative) treatment is of fundamental importance both in conjuncture with life-sustaining interventions and in end of life care. […] Based on the evidence to date, there are several treatment options to consider for the relief of fever (acetaminophen, NSAID, oral glucocorticoids), cough (morphine), breathlessness (morphine, oxygen, fan), anxiety (benzodiazepines) and pain (NSAID, morphine). […] Top priorities include precautions to protect staff and people at-risk from infection and planning how to provide adequate treatment for each individual depending on setting, including palliative care. 2020-04-16
Rapid Detection of COVID-19 Causative Virus (SARS-CoV-2) in Human Nasopharyngeal Swab Specimens Using Field-Effect Transistor-Based Biosensor. Thus, we have successfully fabricated a promising FET biosensor for SARS-CoV-2; our device is a highly sensitive immunological diagnostic method for COVID-19 that requires no sample pretreatment or labeling. 2020-04-15
Treatment with convalescent plasma for COVID-19 patients in Wuhan, China. In order to evaluate the efficacy of convalescent plasma therapy in COVID-19 patients, we did this timely descriptive study. 6 laboratory confirmed COVID-19 patients were enrolled and received the transfusion of ABO-compatible convalescent plasma. […] No obvious adverse effect observed during the treatment. […] In patient #1 and #5 who presented with SARS-CoV-2 in throat swab, convalescent plasma therapy elicited an elimination of virus. […] This study indicates that convalescent plasma therapy is effective and specific for COVID-19. […] This intervention has a special significance for eliminating SARS-CoV-2 and is believed to be a promising state-of-art therapy during COVID-19 pandemic crisis. 2020-04-15
Concomitant neurological symptoms observed in a patient diagnosed with coronavirus disease 2019. The patient recovered after treatment and was discharged. 2020-04-15
Global guidance for surgical care during the COVID-19 pandemic. A backlog of procedures after the end of the COVID-19 pandemic is inevitable, and hospitals should plan how to address this effectively to ensure that patients having elective treatment have the best possible outcomes. 2020-04-15
Systematic review of the efficacy and safety of antiretroviral drugs against SARS, MERS or COVID-19: initial assessment. Several antiretroviral drugs are being considered for the treatment of COVID-19, the disease caused by a newly identified coronavirus, (SARS-CoV-2). […] We systematically reviewed the clinical outcomes of using antiretroviral drugs for the prevention and treatment of coronaviruses and planned clinical trials. […] From an initial screen of 433 titles, two randomized trials and 24 observational studies provided clinical outcome data on the use of antiretroviral drugs; most studies reported outcomes using LPV/r as treatment. […] Of the 21 observational studies reporting treatment outcomes, there were three studies among patients with SARS, six studies among patients with MERS and 12 studies among patients with COVID-19. 2020-04-16
Critically-ill COVID-19 patient. The precautions to be taken against this virus, where our knowledge is extremely small, intensive care units take an indispensable place in pandemic planning. 2020-04-16
ANTIVIRAL TREATMENT OF COVID-19. Currently, there is not any specific effective anti-viral treatment for COVID-19. […] Optimized supportive care remains the mainstay of therapy. […] Despite the urgent need to find an effective antiviral treatment for COVID-19 through randomized controlled studies, certain agents are being used all over the world based on either in-vitro or extrapolated evidence or observational studies. […] Nitazoxanide and ivermectin were also included in this review as they have recently been reported to have an activity against SARS-CoV-2 in-vitro and are licensed for the treatment of some other human infections. 2020-04-15
COVID-19: Prevention and control measures in community. Unfortunately, there is no medication that has been approved by the FDA, gone through controlled studies and demonstrated an effect on the virus for this global pandemic. 2020-04-15
The Science Underlying COVID-19: Implications for the Cardiovascular System. Appropriate treatment for heart failure, arrhythmias, acute coronary syndrome and thrombosis remain important. […] Specific evidence based treatment strategies for COVID-19 will emerge with ongoing global collaboration on multiple approaches being evaluated. 2020-04-15
Coronavirus infections and type 2 diabetes-shared pathways with therapeutic implications. Here we review the basic and clinical science spanning the intersections of diabetes, coronavirus infections, ACE2, and DPP4 biology, highlighting clinical relevance and evolving areas of uncertainty underlying the pathophysiology and treatment of T2D in the context of coronavirus infection. 2020-04-15
Venous thromboembolism in COVID-19 patients. In this retrospective analysis, conducted at the Tongji Hospital of Wuhan, China, it is reported that heparin treatment reduces mortality in subjects affected by severe COVID-19 who have “sepsis-induced coagulopathy”. 2020-04-15
Risk factors for severity and mortality in adult COVID-19 inpatients in Wuhan. The severity on admission, complications, treatment, and outcomes of COVID-19 patients were evaluated. 2020-04-15
A search for medications to treat COVID-19 via in silico molecular docking models of the SARS-CoV-2 spike glycoprotein and 3CL protease. Several antiviral medications: Zanamivir, Indinavir, Saquinavir, and Remdesivir show potential as and 3CLPRO main proteinase inhibitors and as a treatment of COVID-19. […] It is also exciting to uncover that Flavin Adenine Dinucleotide (FAD) Adeflavin, B2 Deficiency medicine, and Coenzyme A, a coenzyme, may also be potentially used for the treatment of SARS-CoV-2 infections. […] The use of these off-label medications may be beneficial in the treatment of the COVID-19. 2020-04-15
[Responsibilities of Weaning Centers during the COVID-19 Pandemic Outbreak - Recommendations for the Assignment of ICU Capacities in COVID-19 Patients as shown by the Berlin-Brandenburg POST-SAVE-Model]. The transfer of the patients after acute care treatment is needed urgently to facilitate the weaning process. […] In a next step we developed a triage algorithm to identify patients at SAVE intensive care units with potential to wean and transfer to weaning institutions - we called POST SAVE. […] This manuscript highlights the algorithms including the use of a standardised digital evaluation tool, the use of trained navigators to facilitate the communication between SAVE intensive care units and weaning institutions and the establishment of a prospective data registry for patient assignment and reevaluation of the weaning potential in the future. 2020-04-15
Hydroxychloroquine use during the COVID-19 pandemic 2020. At present, there are no studies demonstrating the clinical efficacy of hydroxychloroquine for the prophylaxis or treatment of COVID-19 infection. 2020-04-15
[The keypoints in treatment of the critical coronavirus disease 2019 patient(2)]. The treatment of critically ill patients with coronavirus disease 2019(COVID-19) faces compelling challenges. […] In this issue, we’d like to share our first-line treatment experience in treating COVID-19. […] Nutritional support is the basis of treatment. […] It’s important to establish individual therapy regimens and to evaluate, monitor and adjust dynamically. 2020-04-17
[Expert consensus on preventing nosocomial transmission during respiratory care for critically ill patients infected by 2019 novel coronavirus pneumonia]. As such, we developed this consensus recommendations on all those high-risk treatments, based on the current evidence as well as the resource limitation in some areas, with the aim to reduce the nosocomial transmission and optimize the treatment for the COVID-19 pneumonia patients. […] Those recommendations include: (1)Standard prevention and protection, and patient isolation; (2)Patient wearing mask during HFNC treatment; (3)Using dual limb ventilator with filters placed at the ventilator outlets, or using heat-moisture exchanger (HME) instead of heated humidification in single limb ventilator with HME placed between exhalation port and mask; avoid using mask with exhalation port on the mask; (4)Placing filter between resuscitator and mask or artificial airway; (5)For spontaneous breathing patients, placing mask for patients during bronchoscopy examination; for patients receiving noninvasive ventilation, using the special mask with bronchoscopy port to perform bronchoscopy; (6)Using sedation and paralytics during intubation, cuff pressure should be maintained between 25-30 cmH(2)O(1 cmH(2)O=0.098 kPa); (7)In-line suction catheter is recommended and it can be used for one week; (8)Dual-limb heated wire circuits are recommended and only changed with visible soiled; (9)For patients who need breathing support during transportation, placing an HME between ventilator and patient; (10)PSV is recommended for implementing spontaneous breathing trial (SBT), avoid using T-piece to do SBT. […] (11)Avoid unnecessary bronchial hygiene therapy; (12) For patients who need aerosol therapy, dry powder inhaler metered dose inhaler with spacer is recommended for spontaneous breathing patients; while vibrating mesh nebulizer is recommended for ventilated patients and additional filter is recommended to be placed at the expiratory port of ventilation during nebulization. 2020-04-17
[Bronchoalveolar lavage fluid was used to diagnose two cases of 2019-nCoV infection]. The results showed that the positive rate of bronchoalveolar lavage for detection of new coronavirus nucleic acid was high, and bronchoalveolar lavage for suspected or confirmed new coronavirus pneumonia patients with negative detection of nucleic acid in pharynx swabs but still residual lung lesions was helpful for early diagnosis, treatment and prognosis. 2020-04-17
[What we learned from SARS may provide important insights into understanding and management of coronavirus disease 2019]. But the pathogenesis and treatment of the disease are not clear yet. 2020-04-17
[Clinical analysis of 150 cases of 2019 novel coronavirus infection in Nanyang City, Henan Province]. Objective: To analyze the epidemiological characteristics and clinical features of the patients with 2019-nCoV infection in Nanyang City, so as to provide evidence for clinical diagnosis and treatment. Methods: The epidemiology, clinical symptoms, atory and radiologic data of 150 patients with 2019-nCoV infection admitted to the designated hospitals in Nanyang City from January 24,2020 to February 16, 2020 were retrospectively analyzed. Results: The 150 patients with 2019 nCov infection consisted of 67 men and 83 women, and the median age was 45±16 years; 69 of them were the first generation case,60 of them were the second generation case, 6 of them were the third generation case,the median incubation period of the first generation case was 5.4±2.2 days, and the second generation case was 6.7±3.1 days, and the first-generation cases are the majority in severe patients (69%) . […] After active treatment, 45% of patients were discharged according to discharge standards. 33% of sever and critically ill patients were discharged, 49% of them were degraded hospitalization.The average length of hospitalization was 12±4 days. Conclusion: A history of epidemiological exposure, fever, chest CT with signs of pneumonia, normal or decreased WBC, and lymphocytopenia, eosinophilia are the clinical basis for the diagnosis of this disease, and most of the sever patients were the first generation cases. 2020-04-16
[Expert consensus on sleep study and non-invasive positive airway pressure therapy during the epidemic of coronavirus disease 2019]. Sleep study and non-invasive positive airway pressure (NIPAP) therapy can increase the risk of exposure and transmission of new coronaviruses to medical staff and patients. […] Based on the characteristics of sleep-disordered breathing, this consensus elaborates on the recommendations from the following four aspects that include patient and medical staff education, optimization of diagnostic and treatment protocols, sterilization of medical devices and the environment, and control of hospital-acquired infection. 2020-04-16
Shelter Hospital: Glimmers of Hope in Treating Coronavirus 2019. In this comment, we report the unexpected beneficial effect of a deployable rapid-assembly shelter hospital on the prevention and treatment of COVID-19. […] We describe the shelter hospital maintenance, treatment mode and primary treatment methods, which will provide a valuable experience in dealing with public health emergencies, such as COVID-19, for other countries and areas. 2020-04-30
Convalescent plasma: A possible treatment of COVID-19 in India. One postexposure prophylaxis, convalescent (immune) plasma (CP), has shown some success in China and previously in the cure and therapy of other coronaviruses, SARS-1 and Middle East respiratory syndrome. 2020-05-31
Prudently conduct the engineering and synthesis of the SARS-CoV-2 virus. In response to the outbreak of COVID-19 that has been sweeping the world, scientists reconstructed the SARS-CoV-2 rapidly using a synthetic genomics platform, in order to accelerate therapeutics and vaccine development. 2020-05-13
Importance of inclusion of pregnant and breastfeeding women in COVID-19 therapeutic trials. The few trials which allow their inclusion focus on post-exposure prophylaxis or outpatient treatment of milder disease, limiting the options available to pregnant women with severe COVID-19 to compassionate use of remdesivir, or off-label drug use of hydroxychloroquine or other therapies. […] In this Viewpoint, we call attention to the need and urgency to engage pregnant women in COVID-19 treatment trials now in order to develop data-driven recommendations regarding the risks and benefits of therapies in this unique but not uncommon population. 2020-04-30
A Tool to Early Predict Severe Corona Virus Disease 2019 (COVID-19) : A Multicenter Study using the Risk Nomogram in Wuhan and Guangdong, China. Our nomogram could help clinicians to early identify patients who will exacerbate to severe COVID-19, which will enable better centralized management and early treatment of severe patients. 2020-04-30
[Urology in the corona-virus pandemic-a guideline 4/20]. For urology, the expansion of the health-care structures for the treatment of patients suffering from COVID-19 should be supported as best as possible. […] For this, patients must be prioritized individually, alternative therapy concepts must be considered and regional and supraregional cooperation must be used. […] Outpatient departments are of great importance in the care, examination and coordination of urological emergencies and urgent treatment. 2020-04-20
Mechanism of thrombocytopenia in COVID-19 patients. We propose several mechanisms by which coronavirus disease 2019 causes thrombocytopenia to better understand this disease and provide more clinical treatment options. 2020-05-22
Switch from oral anticoagulants to parenteral heparin in SARS-CoV-2 hospitalized patients. The development of COVID-19 syndrome in anticoagulated patients, and especially their admission to intensive-care units with acute severe respiratory syndrome (SARS-CoV-2), expose them to specific problems related to their therapy, in addition to those associated with the acute viral infection. […] Patients on DOAC are exposed to under/over treatment caused by significant pharmacological interferences. […] In consideration of the pharmacological characteristics of oral anticoagulant drugs, the multiple pharmacological interactions due to the treatment of acute disease and the possible necessity of mechanical ventilation with hospitalization in intensive-care units, we suggest replacing oral anticoagulant therapies (VKA and DOAC) with parenteral heparin to avoid the risk of over/under treatment. 2020-05-10
SARS-CoV-2: Recent Reports on Antiviral Therapies Based on Lopinavir/Ritonavir, Darunavir/Umifenovir, Hydroxychloroquine, Remdesivir, Favipiravir and Other Drugs for the Treatment of the NewCoronavirus Here we report on the most recent updates on experimental drugs successfully em-ployed in the treatment of the disease caused by SARS-CoV-2 coronavirus, also referred to asCOVID-19 (COronaVIrus Disease 19). […] Since the recoveries/deathsratio in the last weeks significantly increased, especially in China, it is clear that the experi-mental antiviral therapy, together with the availability of intensive care unit beds in hospitalsand rigorous government control measures, all play an important role in dealing with this vi-rus. 2020-04-21
Relationships among lymphocyte subsets, cytokines, and the pulmonary inflammation index in coronavirus (COVID-19) infected patients. After ‘five-in-one’ treatment, all patients were discharged with the exception of the four who died. 2020-04-30
COVID-2019: update on epidemiology, disease spread and management. At present, treatment of COVID-2019 is mostly based on the knowledge gained from the SARS and MERS outbreaks. […] Remdesivir, originally develop as a treatment for Ebola virus disease and Marburg virus infections, is being studied for it effectiveness against 2019-nCoV infection. 2020-04-20
Calculated Decisions: Brescia-COVID Respiratory Severity Scale (BCRSS)/Algorithm. The BCRSS uses patient examination features along with the need for escalating levels of respiratory support (NIV, intubation, proning) to suggest treatment recommendations. 2020-04-20
Oligonucleotides and the COVID-19 Pandemic: A Perspective. With few safe and effective drugs available to combat this threat to humanity and the normal functioning of our society, the oligonucleotide research community is uniquely positioned to apply its technology and expertise to help alleviate the crisis, thanks to its capacity for rational drug design, swift development cycles, and pursuing targets undruggable by conventional treatment strategies. 2020-05-29
Evaluation of Antiviral Therapies for Coronavirus Disease 2019 (COVID-19) Pneumonia in Shanghai, China. Patients confirmed with COVID-19 pneumonia were enrolled and divided into 7 groups according to the treatment option. […] The chest CT imaging obtained at admission and after a 5-d treatment cycle were assessed. […] No significant differences were found among the groups in terms of the proportion of patients with pneumonia resolution (P=0.151) after treatment or the length of hospital stay (P=0.116). […] According to the results, the inclusion of antiviral drugs in therapeutic regimens based on symptomatic treatment had no significant additional impact on the improvement in COVID-19 patients. 2020-04-16
Off-label Use of Tocilizumab in Patients with SARS-CoV-2 Infection. Particularly, no approved therapy has demonstrated to have an impact in treating patients who develop severe respiratory insufficiency so far. 2020-04-16
Virological and clinical cure in COVID-19 patients treated with hydroxychloroquine: A systematic review and meta-analysis. Treatment with HCQ resulted in less number of cases showing the radiological progression of lung disease (odds ratio [OR], 0.31, 95% confidence interval [CI], 0.11-0.9). […] No difference was observed in virological cure (OR, 2.37, 95% CI, 0.13-44.53), death or clinical worsening of disease (OR, 1.37, 95% CI, 1.37-21.97), and safety (OR, 2.19, 95% CI, 0.59-8.18), when compared with the control/conventional treatment. […] HCQ seems to be promising in terms of less number of cases with radiological progression with a comparable safety profile to control/conventional treatment. 2020-05-03
How to Guarantee the Best of Care to Patients with Cancer During the COVID-19 Epidemic: The Italian Experience. Patients who need to be hospitalized for cancer treatment were protected from potential SARS-CoV-2 infection by creating a dedicated diagnostic and therapeutic internal pathway for cancer treatment. […] Because of the extreme burden created by COVID-19, antitumor treatment was initiated only after considering patient performance status, comorbidities, biology of disease, and the likely impact of treatment on outcome. […] Treatment strategies were discussed in the context of a multidisciplinary tumor board. […] Treatment decision making balanced risk and benefits of treatment in the context of the specific pandemic level, on a case-by-case basis. 2020-04-27
Framework for prioritizing head and neck surgery during the COVID-19 pandemic. Unique considerations for the head and neck patient are examined including risk to the oncology patient, outcomes following delay in head and neck cancer therapy, and risk of transmission during otolaryngologic surgery. 2020-05-29
Geospatial Hotspots Need Point-of-Care Strategies to Stop Highly Infectious Outbreaks: Ebola and Coronavirus. Outbreaks generate geospatial “hotspots.” POC strategies help control hotspots, detect spread, and speed treatment of highly infectious diseases. Objectives. To stop outbreaks, accelerate detection, facilitate emergency response for epidemics, mobilize public health practitioners, enhance community resilience, and improve crisis standards of care. Data Sources. PubMed, WWW, newsprint, others were searched until COVID-19 was declared a pandemic, the US, a national emergency, and Europe, the epicenter. 2020-04-16
The Application of Mobile Telehealth System to Facilitate Patient Information Presentation and Case Discussion. However, out-of-hospital professionals cannot access patient information, which has greatly reduced the efficiency of treatment; it is inconvenient for health care professionals to issue a case discussion with professionals from other wards. 2020-04-16
Timing of Community Mitigation and Changes in Reported COVID-19 and Community Mobility - Four U.S. Metropolitan Areas, February 26-April 1, 2020. Actions such as social distancing are especially critical when medical countermeasures such as vaccines or therapeutics are not available. 2020-04-17
Management of infantile hemangiomas during the COVID pandemic. Infantile hemangiomas (IH) can require urgent evaluation and risk stratification to determine which infants need treatment and which can be managed with continued observation. […] For those requiring treatment, prompt initiation decreases morbidity and improves long-term outcomes. […] FDA/EMA-approved monitoring guidelines, clinical practice guidelines, and relevant, up-to-date publications regarding initiation and monitoring of beta-blocker therapy were used to inform the recommendations. […] Clinical decision-making guidelines about when telehealth is an appropriate alternative to in-office visits, including medication initiation, dosage changes, and ongoing evaluation, are included. […] The importance of communication with caregivers in the context of telemedicine is discussed, and online resources for both hemangioma education and propranolol therapy are provided. 2020-05-16
Successful treatment of plasma exchange followed by intravenous immunogloblin in a critically ill patient with 2019 novel coronavirus infection. The patient avoided mechanical ventilation and acquired an immediate clinical and radiological improvement, after treatment of intensive plasma exchange (PE) followed by intravenous immunogloblin (IVIG). […] Successful therapeutic strategies in our case suggest timely initiating PE treatment followed by IVIG in critically ill patients with COVID-19 may prevent the disease from worsening and help to reduce the requirements for mechanical ventilation and intensive supportive care. 2020-05-05
Grief During the COVID-19 Pandemic: Considerations for Palliative Care Providers. We provide resources for health care providers, in addition to calling on palliative care providers to consider their own role as a resource to other specialties during this public health emergency. 2020-04-27
Are we facing a crashing wave of neuropsychiatric sequelae of COVID-19? Neuropsychiatric symptoms and potential immunologic mechanisms. Fear of illness and uncertainty about the future precipitate anxiety- and stress-related disorders, and several groups have rightfully called for the creation and dissemination of robust mental health screening and treatment programs for the general public and front-line healthcare workers. 2020-04-24
Chimeric Antigen Receptor T Cell Therapy During the COVID-19 Pandemic. The SARS-CoV-2 coronavirus (COVID-19) pandemic has significantly impacted the delivery of cellular therapeutics, including chimeric antigen receptor (CAR) T cells. […] Based on the collective experience of the CAR T-cell Consortium investigators, we review and address several questions and concerns regarding cellular therapy administration in the setting of COVID-19 and make general recommendations to address these issues. […] Specifically, we address (1) necessary resources for safe administration of cell therapies; (2) determinants of cell therapy utilization; (3) selection among patients with B cell non-Hodgkin lymphomas and B cell acute lymphoblastic leukemia; (4) supportive measures during cell therapy administration; (5) use and prioritization of tocilizumab; and (6) collaborative care with referring physicians. […] These recommendations were carefully formulated with the understanding that resource allocation is of the utmost importance, and that the decision to proceed with CAR T cell therapy will require extensive discussion of potential risks and benefits. […] Although these recommendations are fluid, at this time it is our opinion that the COVID-19 pandemic should not serve as reason to defer CAR T cell therapy for patients truly in need of a potentially curative therapy. 2020-05-05
Diabetes in COVID-19: Prevalence, pathophysiology, prognosis and practical considerations. PubMed database and Google Scholar were searched using the key terms ‘COVID-19’, ‘SARS-CoV-2’, ‘diabetes’, ‘antidiabetic therapy’ up to April 2, 2020. 2020-05-27
Linear Regression Analysis to predict the number of deaths in India due to SARS-CoV-2 at 6 weeks from day 0 (100 cases - March 14th 2020). and Aims: No valid treatment or preventative strategy has evolved till date to counter the SARS CoV 2 (Novel Coronavirus) epidemic that originated in China in late 2019 and have since wrought havoc on millions across the world with illness, socioeconomic recession and death. 2020-05-29
COVID-19, immune system response, hyperinflammation and repurposing antirheumatic drugs Regretfully, the exact pathophysiology and treatment, especially for the severe COVID-19, is still uncertain. […] The results of preliminary studies have shown that immune-modulatory or immune-suppressive treatments such as hydroxychloroquine, interleukin (IL)-6 and IL-1 antagonists, commonly used in rheumatology, might be considered as treatment choices for COVID-19, particularly in severe disease. 2020-04-22
Understanding dynamics of pandemics The case definition, finding out cases and first case cluster, proper treatment, sufficient stockpiles of medicine and population cooperation with the containment strategy should be considered for reduction of burden of pandemic. 2020-04-22
Guidance on Minimizing Risk of Drug-Induced Ventricular Arrhythmia During Treatment of COVID-19: A Statement from the Canadian Heart Rhythm Society. If baseline electrocardiographic testing reveals a moderately prolonged QTc, optimization of medications and electrolytes may permit therapy. 2020-05-18
Novel Coronavirus Disease (COVID-19) and Biologic Therapy in Psoriasis: Infection Risk and Patient Counseling in Uncertain Times. Ultimately, treatment decisions should be made on the basis of dialogue between patient and provider, considering each patient’s individualized situation. 2020-05-16
Genomic characterization of a novel SARS-CoV-2. Information on the variation of viruses is of considerable medical and biological impacts on the prevention, diagnosis, and therapy of infectious diseases. 2020-04-21
A geroscience perspective on COVID-19 mortality. These similarities are explored here, and underscore the need to consider the role of basic biological mechanisms of aging on potential treatment and outcomes of COVID-19. 2020-04-30
Clinical characteristics of COVID-19 in children compared with adults in Shandong Province, China. We reported on the epidemiological, clinical, laboratory, and radiological characteristics of children cases to help health workers better understand and provide timely diagnosis and treatment. 2020-05-29
Case report: A kidney transplant patient with mild COVID-19. Here, we report the clinical features and our treatment approach for a kidney transplant patient with a diagnosis of COVID-19. 2020-05-22
Smell dysfunction: a biomarker for COVID-19. Quantitative smell testing demonstrates that decreased smell function, but not always anosmia, is a major marker for SARS-CoV-2 infection and suggests the possibility that smell testing may help, in some cases, to identify COVID-19 patients in need of early treatment or quarantine. 2020-04-17
Walk-Through Screening Center for COVID-19: an Accessible and Efficient Screening System in a Pandemic Situation. However, there is a risk of cross-infection at each stage of screening treatment, including the booths, and adverse reactions with disinfection of the booths. 2020-04-20
A review of initial data on pregnancy during the COVID-19 outbreak: implications for assisted reproductive treatments. However, considering the initial data and lack of comprehensive knowledge on the pathogenesis of SARS-CoV-2 during pregnancy, human reproduction societies have recommended postponing the embryo transfers and do not initiate new treatment cycles. 2020-04-28
Neuroanesthesia Practice During the COVID-19 Pandemic: Recommendations from Society for Neuroscience in Anesthesiology & Critical Care (SNACC). The pandemic of coronavirus disease 2019 (COVID-19) has several implications relevant to neuroanesthesiologists, including neurologic manifestations of the disease, impact of anesthesia provision for specific neurosurgical procedures and electroconvulsive therapy, and healthcare provider wellness. […] This consensus statement provides information on the neurological manifestations of COVID-19, advice for neuroanesthesia clinical practice during emergent neurosurgery, interventional radiology (excluding endovascular treatment of acute ischemic stroke), transnasal neurosurgery, awake craniotomy and electroconvulsive therapy, as well as information about healthcare provider wellness. 2020-05-22
Cardiovascular Pharmacology in the Time of COVID-19: A Focus on Angiotensin Converting Enzyme 2. We review current knowledge of the role of ACE2 in cardiovascular physiology and SARS-CoV-2 virology as well as clinical data to inform the management of patients with or at risk for COVID-19 who require renin-angiotensin-aldosterone system inhibitor therapy. 2020-05-16
Detectable serum SARS-CoV-2 viral load (RNAaemia) is closely correlated with drastically elevated interleukin 6 (IL-6) level in critically ill COVID-19 patients. The patients were divided into three groups according to the “Diagnosis and Treatment of New Coronavirus Pneumonia (6th edition)” issued by the National Health Commission of China. 2020-04-30
Laboratory testing of SARS-CoV, MERS-CoV, and SARS-CoV-2 (2019-nCoV): Current status, challenges, and countermeasures. Rapid and accurate laboratory testing of SARS-CoV-2 is essential for early discovery, early reporting, early quarantine, early treatment, and cutting off epidemic transmission. 2020-05-19
COVID-19 Transmission in Dental Practice: Brief Review of Preventive Measures in Italy. Finally, recommendations based on the Italian experience in terms of patient triage, patients’ entrance into the practice, dental treatment, and after-treatment management are reported and discussed. 2020-04-17
Brief Summary of Potential SARS-CoV-2 Prophylactic and Treatment Drugs in the Emergency Department. The National Institutes of Health is conducting a Phase 1 clinical trial to evaluate for a potential vaccine and the recipients have started to receive the investigational vaccine.2 We present a brief overview of the potential prophylactic and treatment agents under investigation, some which could be initiated in the ED if proven effective. 2020-05-21
Clinical Pharmacology Perspectives on the Antiviral Activity of Azithromycin and Use in COVID-19. It is primarily used for the treatment of respiratory, enteric, and genitourinary bacterial infections. […] AZ is not approved for the treatment of viral infections, and there is no well-controlled, prospective, randomized clinical evidence to support AZ therapy in coronavirus disease 2019 (COVID-19). […] Nevertheless, there are anecdotal reports that some hospitals have begun to include AZ in combination with hydroxychloroquine or chloroquine (CQ) for treatment of COVID-19. […] It is essential that the clinical pharmacology (CP) characteristics of AZ be considered in planning and conducting clinical trials of AZ alone or in combination with other agents, to ensure safe study conduct and to increase the probability of achieving definitive answers regarding efficacy of AZ in the treatment of COVID-19. 2020-05-12
Phototherapeutic approach to dermatological patients during the 2019 Coronavirus pandemic: Real-life Data from the Italian Red Zone. Although COVID-19 does not have epidermotropism, cutaneous manifestations in Cov-19 positive patients have been reported [3] and departments of dermatology are considered at high risk [4] and were ordered to admit only patients needing urgent treatments or undergoing chronic immunosuppressive therapy in order to minimize nosocomial virus spread. 2020-04-17
Hypercoagulability of COVID-19 patients in Intensive Care Unit. A Report of Thromboelastography Findings and other Parameters of Hemostasis. These findings may explain the events of venous thromboembolism observed in some of these patients and support antithrombotic prophylaxis/treatment. 2020-04-17
The procoagulant pattern of patients with COVID-19 acute respiratory distress syndrome. Further studies are needed to assess the best prophylaxis and treatment of this condition. 2020-05-06
ISTH interim guidance on recognition and management of coagulopathy in COVID-19: A Comment. While we agree that this interim guidance addresses important considerations for monitoring the disease process, we believe that the proposed treatment strategy of prophylactic low molecular weight heparin (LMWH) to treat severe COVID-19 coagulopathy is an unconvincing strategy. 2020-04-17
Practice Recommendations for Risk-Adapted Head and Neck Cancer Radiation Therapy During the COVID-19 Pandemic: An ASTRO-ESTRO Consensus Statement. Two pandemic scenarios, early (risk mitigation) and late (severely reduced radiation therapy resources), were evaluated. […] The panel developed treatment recommendations for 5 HNC cases. […] There was agreement or strong agreement across a number of practice areas, including treatment prioritization, whether to delay initiation or interrupt radiation therapy for intercurrent SARS-CoV-2 infection, approaches to treatment (radiation dose-fractionation schedules and use of chemotherapy in each pandemic scenario), management of surgical cases in event of operating room closures, and recommended adjustments to outpatient clinic appointments and supportive care. 2020-05-27
When health professionals look death in the eye: the mental health of professionals who deal daily with the 2019 coronavirus outbreak. It has been associated with anxiety including multiple clinical activities, depression in the face of the coexistence of countless deaths, long work shifts with the most diverse unknowns and demands in the treatment with patients with COVID-19. 2020-05-19
Epidemiological characteristics and clinical features of 32 critical and 67 noncritical cases of COVID-19 in Chengdu. Early detection and identification of critically ill patients is necessary to facilitate scientific classification and treatment. […] We collected and analyzed epidemiological, demographic, clinical, laboratory, radiological, and treatment data. 2020-05-27
Health Communication Through News Media During the Early Stage of the COVID-19 Outbreak in China: Digital Topic Modeling Approach. The top three most popular themes were prevention and control procedures, medical treatment and research, and global or local social and economic influences, accounting for 32.57% (n=2538), 16.08% (n=1258), and 11.79% (n=919) of the collected reports, respectively. 2020-05-04
Considerations for Obstetric Care during the COVID-19 Pandemic. Because no treatment, no vaccine and no herd immunity exist, social distancing is the best mechanism available to protect patients and health care workers from infection. 2020-04-17
Two known therapies could be useful as adjuvant therapy in critical patients infected by COVID-19. In this document we review two simple adjuvant therapies to administer, without side effects, and low cost that could be useful for the treatment of acute severe coronavirus infection associated with acute respiratory syndrome (SARS-CoV-2). […] VitaminC, a potent antioxidant, has emerged as a relevant therapy due to its potential benefits when administered intravenous. […] Another potential effective therapy is ozone: it has been extensively studied and used for many years and its effectiveness has been demonstrated so far in multiples studies. 2020-05-21
Approaches to the management of patients in oral and maxillofacial surgery during COVID-19 pandemic. Specialties with overlap in therapies should have well defined arrangements among each other concerning the treatment spectra in order to avoid redundancy and loss of resources. 2020-05-12
French consensus on management of head and neck cancer surgery during COVID-19 pandemic. In the context of the current pandemic, there is a need for specific advice concerning treatment of patients with Head and Neck cancers. 2020-05-22
Chloroquine and COVID-19 - a potential game changer? One potential treatment is chloroquine and its derivatives, including hydroxychloroquine, which have both antiviral and anti-inflammatory effects. 2020-04-18
Harnessing CAR T-cell Insights to Develop Treatments for Hyperinflammatory Responses in Patients with COVID-19. We discuss approaches to decrease the morbidity and mortality in patients with COVID-19 by repurposing existing drugs previously developed for cancer therapy. 2020-05-02
British Society of Gastroenterology guidance for management of inflammatory bowel disease during the COVID-19 pandemic. Further considerations are given to service provision, medical and surgical therapy, endoscopy, imaging and clinical trials. 2020-05-13
Covid-19 and immunomodulation in IBD. Moreover, the potential implications of these new insights for immunomodulation and biological therapy in IBD are discussed. 2020-05-14
COVID-19 tsunami: the first case of a spinal cord injury patient in Italy. His general practitioner suspected a urinary tract infection and prescribed him antibiotic therapy. […] After 2 days of antibiotic therapy the fever still persisted, so the individual was admitted to the local hospital and treated with broad-spectrum antibiotics. […] Considering the worsening of the chest X-ray and fever despite 48 h of broad-spectrum antibiotic therapy, we strongly suspected viral pneumonia. […] SARS-CoV-2 was detected and antiviral therapy with Lopinavir/Ritonavir, associated with hydroxychloroquine, was promptly started. […] Fever ceased after 2 days of therapy. […] Moreover, routine testing of patients who have to participate in therapy in common gym areas may be warranted. 2020-04-24
[A cross sectional study on patients with inflammatory rheumatic diseases in terms of their compliance to their immunsuppressive medication during COVID-19 pandemic]. In the recommendations of the German Society for Rheumatology (www.dgrh.de), it is recommended that our patients continue the antirheumatic therapy to maintain remission or low state of activity despite the pandemic. […] In this study, patients with inflammatory rheumatic disease were asked in the first weeks of the pandemic on their opinion of their immunomodulating therapy. […] The result shows that over 90% of the patients followed the recommendation of the rheumatologist to continue the antirheumatic therapy, and only a small percentage of the patients terminated the therapy on their own. […] This result was independent of the individual anti-rheumatic therapy. 2020-05-08
Summary of 20 tracheal intubation by anesthesiologists for patients with severe COVID-19 pneumonia: retrospective case series. All meet the indication for tracheal intubation announced by treatment expert group. 2020-05-08
The Burden of COVID-19 in People Living with HIV: A Syndemic Perspective. These burdens can affect the physical, emotional, and social well-being of PLWH and interfere with the delivery of effective healthcare and access to HIV treatment. 2020-05-25
Novel coronavirus disease (COVID-19) in children The epidemiological and clinical patterns of COVID-19 and treatment approaches in pediatric patients still remain unclear although many pediatric reports are published. […] This review aims to summarize the current epidemics, clinical presentations, diagnosis, and treatment of COVID-19 in pediatric patients. 2020-04-22
COVID-19 outbreak control, example of ministry of health of Turkey “COVID-19 Risk Assessment”, “COVID-19 Guideline” and “Case Report Form”, regulations of personal protective equipment along with need-based guidelines, treatment algorithms, brochures and related documents have been released. 2020-04-22
The impact of coronavirus infectious disease 19 (COVID-19) on oral health. Urgent joined research efforts regarding the SARS-COV-2 rapid tests, accurate diagnosis, especially early recognition, and effective treatment of life-threatening complications would be highly desirable for humanity and medical workforce all over the world that try to combat a current global pandemic threat. […] Due to indirect complex effect, intensified COVID-19 therapies and multi-drug treatment, it is believed that some oral conditions could be aggravated by COVID-19 disease, particularly those with autoimmune aetiology, linked to compromised immune system or long-term pharmacotherapy. 2020-05-06
Contributory Role of Positron Emission Tomography in a Left Ventricular Assist Device Recipient at the Time of COVID-19 Pandemic. Thus, extreme caution and thoughtful approaches should be taken for a timely detection in delicate LVAD populations, especially if patients are living in a high-density COVID-19-infected area, and the potential intention for LVAD treatment is bridge to transplantation. 2020-05-30
First successful treatment of COVID-19 induced refractory cardiogenic plus vasoplegic shock by combination of pVAD and ECMO - a case report. Complications on the intensive care units include acute respiratory distress syndrome, acute cardiac- and kidney injury as well as shock.Here, we present the first case report of a successful treatment of a COVID-19 patient presenting with ARDS plus refractory combined cardiogenic and vasoplegic shock, which could be successfully stabilized after implantation of a percutaneous ventricular assist device (pVAD) plus an extracorporeal membrane oxygenation (ECMO). […] While such intense treatment might not be feasible in case of a health care disaster as described for the hot spots of the COVID-19 pandemic, it might encourage treatment of younger patients on intensive care units not overcrowded by critically ill patients. 2020-05-15
COVID-19 Respiratory Failure: Targeting Inflammation on VV-ECMO Support. The outbreak of novel coronavirus (SARS-CoV-2) that causes the respiratory illness COVID-19 has led to unprecedented efforts at containment due to its rapid community spread, associated mortality, and lack of immunization and treatment. […] Through treatment targeting hyperinflammation, he recovered from critical COVID-19 respiratory failure and required only 160 hours of VV-ECMO support. 2020-05-30
The performance of chest CT in evaluating the clinical severity of COVID-19 pneumonia: identifying critical cases based on CT characteristics. In our critical cases, eight patients with relative volume of normal lung density smaller than 40% received mechanical ventilation for supportive treatment, and two of them had died. 2020-04-23
The Impact of the COVID-19 Pandemic on Cancer Patients. Currently, there is no specific treatment or approved vaccine against COVID-19 and many clinical trials are currently investigating potential medications to treat COVID-19. […] The immunosuppressed status of some cancer patients (whether caused by the disease itself or the treatment) increases their risk of infection compared with the general population. 2020-05-29
Thromboembolic risk and anticoagulant therapy in COVID-19 patients: emerging evidence and call for action. The incidence of venous thromboembolism among COVID-19 patients in intensive care units appears to be somewhat higher compared to that reported in other studies including such patients with other disease conditions. […] Preliminary data show that in patients with severe COVID-19, anticoagulant therapy appears to be associated with lower mortality in the subpopulation meeting sepsis-induced coagulopathy criteria or with markedly elevated d-dimer. 2020-05-04
Coronavirus Outbreak: Is Radiology Ready? Mass Casualty Incident Planning. A significant increase is expected in the number of imaging studies ordered for the initial diagnosis and treatment follow-up of cases of COVID-19. 2020-05-01
Angiotensin receptor blockers and COVID-19. For these reasons ARB therapy must be continued for patients affected by hypertension, diabetes and renal disease, comorbidities of the current COVID-19 pandemic. […] Controlled clinical studies should be conducted to determine whether ARBs may be included as additional therapy for COVID-19 patients. 2020-05-20
Risk Factors of Fatal Outcome in Hospitalized Subjects With Coronavirus Disease 2019 From a Nationwide Analysis in China. Earlier identification, more intensive surveillance, and appropriate therapy should be considered in patients at high risk. 2020-05-28
COVID-19: Four Paediatric Cases in Malaysia. None required antiviral therapy. 2020-05-20
Challenges and solutions for addressing critical shortage of supply chain for personal and protective equipment (PPE) arising from Coronavirus disease (COVID19) pandemic - Case study from the Republic of Ireland. Reprocessing PPE must consider material composition, functionality post treatment, along with appropriate disinfection. 2020-05-27
Epidemiological and initial clinical characteristics of patients with family aggregation of COVID-19. Epidemiological data and laboratory and imaging results were collected on the first day of admission, and analyzed based on the Diagnosis and Treatment Guideline for COVID-19 (5th edition, China). 2020-05-27
ESPEN expert statements and practical guidance for nutritional management of individuals with SARS-CoV-2 infection. Prevention, diagnosis and treatment of malnutrition should therefore be routinely included in the management of COVID-19 patients. 2020-05-31
American Society for Transplantation and Cellular Therapy Pharmacy Special Interest Group Position Statement on Pharmacy Practice Management and Clinical Management for COVID-19 in Hematopoietic Cell Transplantation and Cellular Therapy Patients in the United States. The coronavirus-19 (COVID-19) pandemic poses a significant risk to patients undergoing hematopoietic stem cell transplantation (HCT) or cellular therapy. […] The American Society for Transplantation and Cellular Therapy Pharmacy Special Interest Group Steering Committee aims to provide pharmacy practice management recommendations for how to transition clinical HCT or cellular therapy pharmacy services using telemedicine capabilities in the inpatient and outpatient settings to maintain an equivalent level of clinical practice while minimizing viral spread in a high-risk, immunocompromised population. […] In addition, the Steering Committee offers clinical management recommendations for COVID-19 in HCT and cellular therapy recipients based on the rapidly developing literature. 2020-05-29
Clinical Implications of SARS-Cov2 Interaction with Renin Angiotensin System. Based on the anti-inflammatory benefits of the upregulation of the ACE2/Ang1-7/Mas axis and previously demonstrated benefits of lung function improvement in SARS-CoV infections, we hypothesize that the benefits of treatment with renin-angiotensin system inhibitors in SARS-COV2 may outweigh the risks and at the very least should not be withheld. 2020-04-21
Practical diagnosis and treatment of suspected venous thromboembolism during COVID-19 pandemic. In the present report, we have summarized a broad institutional consensus focusing on evaluation and recommended empirical therapy for COVID-19-positive patients. 2020-05-16
Can post-exposure prophylaxis for COVID-19 be considered as an outbreak response strategy in long-term care hospitals? Although several drugs have been proposed as treatment options, there are no data on the effectiveness and safety of post-exposure prophylaxis (PEP) for COVID-19. 2020-04-29
Combating Devastating COVID -19 by Drug Repurposing. The article emphases the possible drug candidates in the treatment of COVID-19 infection. 2020-04-24
Flash survey on severe acute respiratory syndrome coronavirus-2 infections in paediatric patients on anticancer treatment. Comorbidities, in particular, diabetes and hypertension, clearly associated with age, besides obesity and smoke, are strongly associated with the need for intensive treatment and a dismal outcome. […] We made a flash survey on COVID-19 incidence and severity among children on anticancer treatment. […] We also discuss preventive measures that are in place or should be taken and treatment options in immunocompromised children with COVID-19. […] While we should not underestimate the risk of developing a more severe course of COVID-19 than that observed here, the intensity of preventive measures should not cause delays or obstructions in oncological treatment. 2020-05-29
Multiple Myeloma in the Time of COVID-19. We do not recommend therapy for smoldering myeloma patients (standard or high risk). […] Screening for COVID-19 should be done in all patients before therapy. […] Patients on current maintenance should continue their therapy. 2020-05-16
[Analysis of special ehealth service for corona virus disease 2019 (COVID-19) pneumonia]. The application of “Internet+medical treatment” in community medical institutions and synergy among various institutions should be promoted. 2020-04-22
COVID-19 in otolaryngologist practice: a review of current knowledge. This study provides a brief and precise review of the current knowledge regarding COVID-19, including disease transmission, clinical characteristics, diagnosis, and potential treatment. 2020-04-30
Surge capacity of intensive care units in case of acute increase in demand caused by COVID-19 in Australia. To assess the capacity of intensive care units (ICUs) in Australia to respond to the expected increase in demand associated with COVID-19. 2020-05-31
Cardiac involvement in COVID-19 patients: Risk factors, predictors, and complications: A review. While some information is available, further studies are imperative for a more cohesive understanding of the cardiac pathophysiology in COVID-19 patients to promote more informed treatment and, ultimately, better clinical outcomes. 2020-04-19
Successful guselkumab treatment in a psoriatic patient affected with Cornelia de Lange syndrome, and prosecution during the COVID-19 pandemic. Eventually, she adhered to guselkumab treatment. […] The compliance was excellent, significant improvements were observed after only 3 months of treatment, without adverse effects. […] In agreement with current Italian recommendations, risk and benefits profile was discussed with the patient’s legal tutor and the decision to continue the treatment was taken. 2020-04-29
[Clinical features and outcome of treatment for novel coronavirus pneumonia: a meta-analysis]. Objective: To investigate the clinical features and outcome of treatment for novel coronavirus pneumonia. Methods: Literature on novel coronavirus pneumonia was retrieved from PubMed and EMBASE databases. […] Mechanical ventilation (13.4%), extracorporeal membrane oxygenation (1.9%), and continuous renal replacement therapy (3.8%) were used in severe cases. 2020-04-20
Chinese expert consensus on diagnosis and treatment of coagulation dysfunction in COVID-19. Therefore, the People’s Liberation Army Professional Committee of Critical Care Medicine and Chinese Society on Thrombosis and Hemostasis grouped experts from the frontline of the Wuhan epidemic to come together and develop an expert consensus on diagnosis and treatment of coagulation dysfunction associated with a severe COVID-19 infection. […] This consensus includes an overview of COVID-19-related coagulation dysfunction, tests for coagulation, anticoagulation therapy, replacement therapy, supportive therapy and prevention. 2020-04-23
Clinical Consensus Recommendations Regarding Non-Invasive Respiratory Support in the Adult Patient with Acute Respiratory Failure Secondary to SARS-CoV-2 infection. The document provides clinical recommendations for the noninvasive respiratory support (noninvasive ventilation, high flow oxygen therapy with nasal cannula) in any patient with suspected or confirmed presentation of COVID-19 with acute respiratory failure. 2020-05-21
Assessing the Burden of Nondeferrable Major Uro-oncologic Surgery to Guide Prioritisation Strategies During the COVID-19 Pandemic: Insights from Three Italian High-volume Referral Centres. We found that approximately two-thirds of elective major uro-oncologic surgeries can be safely postponed or changed to another treatment modality when the availability of health care resources is reduced. 2020-04-22
Treatment options for COVID-19: The reality and challenges. Despite the worsening trends of COVID-19, no drugs are validated to have significant efficacy in clinical treatment of COVID-19 patients in large-scale studies. […] The roles of teicoplanin (which inhibits the viral genome exposure in cytoplasm) and monoclonal and polyclonal antibodies in the treatment of SARS-CoV-2 are under investigation. 2020-05-02
Severe cerebral involvement in adult-onset hemophagocytic lymphohistiocytosis. Timely diagnosis and treatment may be lifesaving. […] OBJECTIVE: To raise awareness about the importance of early diagnosis and treatment of HLH with neurological involvement to prevent serious complications and demise. 2020-04-23
[Practical update of total dose compensation in case of temporary interruption of external radiotherapy in the COVID-19 pandemic context]. Overall treatment time is an important factor of local recurrence and indirectly of distant evolution, namely in case of protracted treatments. […] The models used to compensate the total dose in case of temporary treatment interruption are well known but it is of importance in that pandemic context to update and homogenize clinical practice in order to improve local control without increasing normal tissue complications. 2020-04-26
Medication management and adherence during the COVID-19 pandemic: Perspectives and experiences from low-and middle-income countries. The contribution of community pharmacists in these facilities to manage chronic conditions and promote medication adherence during this COVID-19 pandemic will be essential in easing the burden on already strained health systems. 2020-04-23
Psychological support in times of COVID-19: the Essen community-based CoPE concept. Little is known about treatment options to combat the novel virus, but the same applies to the effects of COVID-19 on people’s mental health. 2020-04-30
Down-regulated gene expression spectrum and immune responses changed during the disease progression in COVID-19 patients. Here, we investigated the clinical, cytokine levels, T cell proportion and related gene expression occurring in COVID-19 patients on admission and after intial treatment. 11 patients diagnosed as COVID-19 with similar initial treatment regimen were enrolled in the hospital. […] IL-10 level was significantly varied with disease progression and treatment. […] The decreased T cell proportions were observed in COVID-19 patients especially in severe cases, and all elevated to normal in mild patiens after initial treatment but only CD4+T cells return to normal in severe cases. […] The number of DEGs increased with the disease progress, and decreased after initial treatment. […] Our findings show a decreased T cell proportion with down-regulated gene expression related to T cell activation and differentiation were occurred in COVID-19 severe patients, which may help to provide effective treatment strategies for COVID-19 . 2020-04-30
Therapeutic strategies for critically ill patients with COVID-19. In the present article, we have summarized the promising drugs, adjunctive agents, respiratory supportive strategies, as well as circulation management, multiple organ function monitoring and appropriate nutritional strategies for the treatment of COVID-19 in the ICU based on the previous experience of treating other viral infections and influenza. 2020-04-23
CD147 as a Target for COVID-19 Treatment: Suggested Effects of Azithromycin and Stem Cell Engagement. The expressive number of deaths and confirmed cases of SARS-CoV-2 call for an urgent demand of effective and available drugs for COVID-19 treatment. 2020-05-29
COVID-19 and spinal cord injuries: The viewpoint from an emergency department resident with quadriplegia. The same disruptions can affect management of this vulnerable patient group, perhaps warranting early aggressive treatment. 2020-04-29
[COVID-19, THE KIDNEY AND HYPERTENSION]. However, hemodialysis patients represent a unique group of patients, mostly elderly and immunocompromised, for whom dialysis is a life-saving treatment which cannot be stopped. 2020-04-21
CoViD-19 Immunopathology and Immunotherapy. The relevance of these interventions for the prevention and treatment of CoViD-19 is discussed. 2020-04-23
Epidemiologic and Clinical Characteristics of 26 Cases of COVID-19 Arising from Patient-to-Patient Transmission in Liaocheng, China. The patients received the following treatments: antiviral therapy (100%), Chinese medicine (76.92%), antibiotics (50%), gastric mucosal protection (19.23%), immunotherapy (7.69%), and glucocorticoids (3.85%). […] Most patients (25/26) required ≥1 treatment. 2020-04-23
Treatment efficacy analysis of traditional Chinese medicine for novel coronavirus pneumonia (COVID-19): an empirical study from Wuhan, Hubei Province, China. Compound quercetin, luteolin, kaempferol, acacetin etc., were all involved in the treatment of various disease stages on the compound level both in generality and individuality. […] The CMs of ISRD improved patients’ recovery, suggesting the importance of regulating intestinal function and keeping microenvironmental balance in TCM treatment of NCP. 2020-04-23
COVID-19 Clinical Trials: A Primer for the Cardiovascular and Cardio-Oncology Communities. Here we have provided a foundation for cardiovascular and cardio-oncology physicians who are on the frontline providing care to COVID-19 patients, so that they can better understand the emerging cardiovascular epidemiology of COVID-19, as well as the biological rationale for the clinical trials that are ongoing for the treatment of COVID-19 patients. 2020-05-31
Antiviral therapy in management of COVID-19: a systematic review on current evidence. The purpose of the current systematic review is to evaluate the efficacy of antiviral therapies in treatment of COVID-19. […] In addition, clinical trials on the efficacy of antiviral therapies in the management of Severe Acute Respiratory Syndrome coronavirus (SARS-Cov) or Middle East Respiratory Syndrome coronavirus (MERS-CoV) have also been reviewed, in order to identify potential treatment options for COVID-19. […] Only one clinical trial on the efficacy of antiviral therapy in management of COVID-19 was found. […] The results depicted that adding Lopinavir-Ritonavir to the standard treatment regimen of patients with severe COVID-19 has no benefits. […] The current evidence impede researchers from proposing an appropriate antiviral therapy against COVID-19, making the current situation a serious concern for international organizations such as World Health Organization (WHO). 2020-04-23
Prone Position in Management of COVID-19 Patients; a Commentary. Among the introduced treatment methods for management of ARDS patients, prone position can be used as an adjuvant therapy for improving ventilation in these patients. 2020-04-23
Coronavirus drugs: Using plasma from recovered patients as a treatment for COVID-19. No antiviral therapies or vaccines are available for their treatment or prevention. 2020-05-27
Coronavirus Infections in Children Including COVID-19: An Overview of the Epidemiology, Clinical Features, Diagnosis, Treatment and Prevention Options in Children. In this review, we summarize epidemiologic, clinical and diagnostic findings, as well as treatment and prevention options for common circulating and novel CoVs infections in humans with a focus on infections in children. 2020-04-24
[The role of multimodality imaging in COVID-19 patients: from diagnosis to clinical monitoring and prognosis]. The integrated clinical, laboratory and ultrasound approach is essential for the diagnosis, monitoring and evaluation of the patient’s therapy in COVID-19 pneumonia. 2020-04-22
[Being a cardiologist at the time of SARS-COVID-19: is it time to reconsider our way of working?] If this, on one hand, results in reducing improper access to the ER and hospital, on the other hand it substantiates the risk of underestimating problems not connected to COVID-19, such as an increased delay in the diagnosis and treatment of acute myocardial infarction and other cardiovascular emergencies. 2020-04-22
Management challenges for chronic dysimmune neuropathies during the COVID-19 pandemic. Therapeutic decisions need, more than ever before, to be considered in the best interests of both patients, and society, while not denying function-preserving/restoring treatment. […] Immunoglobulin therapy and plasma exchange, for those treated outside of the home, expose patients to the hazards of hospital or outpatient infusion centers. […] Steroid therapy initiation and continuation pose increased infectious risk. […] Immunosuppressant therapy similarly becomes highly problematic, with the risks of treatment continuation enhanced by uncertainties regarding duration of the pandemic. 2020-04-24
Description of COVID-19 cases along with the measures taken on prevention and control in Zhejiang, China. The government should take emergent and effective measures to prevent and treatment of the pandemic disease. 2020-05-22
Detection and analysis of nucleic acid in various biological samples of COVID-19 patients. COVID-19 diagnostic criteria: according to China’s ⟪pneumonia diagnosis and treatment Program of novel coronavirus infection (trial version 7) ⟫, in accordance with the relevant epidemiological and clinical manifestations, nasopharyngeal swabs real-time fluorescence RT-PCR detection of 2019-nCoV nucleic acid positive, COVID-19 cases were divided into mild, ordinary, severe and severe [1]. […] RESULTS: | 132 the results of 2019-nCoV nucleic acid test of various biological samples during the treatment of confirmed COVID-19 cases are as follows: the positive rate of 2019-nCoV nucleic acid test of nasopharyngeal swab is 38.13% (180/472 times), the positive rate of 2019-nCoV nucleic acid test of sputum is 48.68% (148/304 times), the positive rate of blood 2019-nCoV nucleic acid test is 3.03% (4/132 times), and the positive rate of 2019-nCoV nucleic acid test of feces is 9.83% (24/244 times). […] Simple detection of nasopharyngeal swab 2019-nCoV nucleic acid detection positive rate is not high, multi-sample 2019-nCoV nucleic acid detection can improve the accuracy, reduce the false negative rate, better guide clinical treatment and evaluate the therapeutic effect. 2020-05-13
COVID-19 and Thrombotic or Thromboembolic Disease: Implications for Prevention, Antithrombotic Therapy, and Follow-up. In addition, many patients receiving antithrombotic therapy for thrombotic disease may develop COVID-19, which can have implications for choice, dosing, and laboratory monitoring of antithrombotic therapy. 2020-04-23
Reorganisation of medical oncology departments during the novel coronavirus disease-19 pandemic: a nationwide Italian survey. Oncologists need to preserve the continuum of care of patients, as the benefit of ensuring a well-delivered anti-cancer treatment plan outweighs the risk of COVID-19 infection. 2020-05-29
SARS-Cov-2 infection: Response of human immune system and possible implications for the rapid test and treatment. Indeed, this test represents an important immunological tool aimed at identifying the precise phase of the infection in order to undertake a more appropriate pharmacological treatment. 2020-05-28
Inactivation of severe acute respiratory syndrome coronavirus 2 in plasma and platelet products using a riboflavin and ultraviolet light-based photochemical treatment. In both experiments, the measured titre of SARS-CoV-2 was below the limit of detection following treatment with riboflavin and UV light. 2020-05-14
COVID-19 and the clinical hematology laboratory. In addition to its central role in the diagnosis of COVID-19 infection, the clinical laboratory provides critical information to clinicians regarding prognosis, disease course, and response to therapy. 2020-04-20
Thromboembolic events and apparent heparin resistance in patients infected with SARS-CoV-2. A large number of these patients end up in the intensive care units (ICU) with critical illness requiring mechanical ventilation. 2020-04-20
Variable computed tomography appearances of COVID-19. Computed tomography (CT) has been described as a diagnostic modality in the COVID-19 diagnosis and treatment plan. 2020-04-21
Coronavirus disease 2019 (COVID-19): two case reports from a family cluster. Here, we report a family cluster case of a father and a son diagnosed as COVID-19 at our hospital, and described the clinical manifestations, laboratory results, CT changes, diagnosis and treatment strategy of these two patients. […] Focus on the value of these two methods in the diagnosis and treatment of diseases, as well as their respective deficiencies. […] For patient 1 (father), the efficacy of RT-PCR is not satisfactory either in terms of diagnosis or follow-up, which may cause misdiagnosis and delay treatment. 2020-04-21
Impact of the COVID-19 Pandemic on the Management of Head and Neck Malignancies. The medical complexity of head and neck cancer management may lead to prolonged delays that worsen treatment outcomes. 2020-04-21
Salvage use of tissue plasminogen activator (tPA) in the setting of acute respiratory distress syndrome (ARDS) due to COVID-19 in the USA: a Markov decision analysis. Two patient groups were simulated (50,000 patients in each group); (1) Patients received tPA immediately upon diagnosis of ARDS and (2) patients received standard therapy for ARDS. 2020-04-23
[Clinical features of children with SARS-CoV-2 infection: an analysis of 115 cases]. Among the 115 children, 3 were critically ill, among whom 1 had been cured and the other 2 were under continuous treatment. 2020-04-22
[Research advances in cardiovascular system damage caused by SARS-CoV-2 in children]. Based on a literature review, this article discusses the possible cardiovascular system damage caused by SARS-CoV-2 in children and related mechanisms, in order to provide help for the timely treatment and prevention of cardiovascular system damage caused by SARS-CoV-2 in children. 2020-04-22
Advice Regarding Systemic Therapy in Patients with Urological Cancers During the COVID-19 Pandemic. We provide treatment advice as a pragmatic perspective on the risk/benefit ratio in specific clinical scenarios. 2020-05-28
[Ensuring mental health care during the SARS-CoV-2 epidemic in France: A narrative review]. We could also face major issues in referring patients with acute mental disorders to intensive care units. 2020-05-08
Experience and suggestion of medical practices for burns during the outbreak of COVID-19. The Chinese government has formally set COVID-19 in the statutory notification and control system for infectious diseases according to the Law of the People’s Republic of China on the Prevention and Treatment of Infectious Diseases. […] Based on our own experience and the guidelines on the diagnosis and treatment of COVID-19 (7th Version) with other regulations and literature, we describe our experience with suggestions for medical practices for burn units during the COVID-19 outbreak. 2020-04-23
Clinical consensus recommendations regarding non-invasive respiratory support in the adult patient with acute respiratory failure secondary to SARS-CoV-2 infection. The document provides clinical recommendations for the noninvasive respiratory support (noninvasive ventilation, high flow oxygen therapy with nasal cannula) in any patient with suspected or confirmed presentation of COVID-19 with acute respiratory failure. 2020-04-21
Adapting to a Pandemic - Conducting Oncology Trials during the SARS-CoV-2 Pandemic. For patients already enrolled however, there are challenges in continuing treatment on trial. 2020-05-21
Guidelines for the management of surgical departments in non-uniform hospitals during the COVID-19 pandemic. Therefore, determining the algorithm becomes crucial for qualifying patients for surgical treatment, but also to stratify the risk of personnel being infected during surgery and to adequately protect staff. 2020-04-22
2019 novel coronavirus: an emerging global threat. Treatment is largely supportive, with regimens including antiviral therapy. 2020-04-23
A short review on antibody therapy for COVID-19. To date, the anti-malaria drug hydroxychloroquine found to be a treatment option for SARS-CoV-2. […] In addition to supportive treatment, such as oxygen supply in moderate cases and extracorporeal membrane oxygenation in critically ill patients, unique medications for this condition are also under investigation. […] Here we reviewed the antibody therapy might be an immediate strategy for emergency prophylaxis and SARS-CoV-2 therapy. 2020-05-31
Veno-venous extracorporeal membrane oxygenation for severe pneumonia: COVID-19 case in Japan. Lopinavir/ritonavir was given; continuous renal replacement therapy was also introduced. […] Treatment of severe pneumonia in COVID-19 by ECMO should recognize lung plasticity considering time to ECMO introduction and interstitial biomarkers. 2020-04-23
Optimization of the intravenous infusion workflow in the isolation ward for patients with coronavirus disease 2019. The infusion management group optimized the intravenous infusion workflow based on Hamer’s Process Reengineering Theory and applied it to the treatment of patients with coronavirus disease 2019. 2020-04-23
One month of the novel coronavirus 2019 outbreak: Is it still a threat? Presently, there is no specific treatment or vaccine but physicians are battling with the use of antibiotics, steroid, anti-viral and anti-HIV drugs and some of the infected cases are testified improved. 2020-04-23
Coronavirus as silent killer: recent advancement to pathogenesis, therapeutic strategy and future perspectives. No Food and Drug Administration approved treatment is available till date. […] In this review, we are tried to explore the epidemiology, pathogenesis and current treatment of CoVs infection. […] The promising therapeutics molecules against CoVs and future prospective have been also discussed which will be helpful for researchers to find out the new molecules for the treatment of CoVs disease. 2020-04-23
PAK1-blockers: Potential Therapeutics against COVID-19. Since Louis Pateur who developed a vaccine against rabies in 1885, in general a series of “specific” vaccines have been used for treatment of viral infection, mainly because antibiotics in general are ineffective for treatment of viral infection. […] Thus, as alternative potentially more direct “broad-spectrum” COVID-19 therapeutics, several natural and synthetic PAK1-blockers such as propolis, melatonin, ciclesonide, hydroxy chloroquine (HQ), ivermection, and ketorolac, which are readily available in the market, are introduced here. 2020-04-23
Inhaled biguanides and mTOR inhibition for influenza and coronavirus (Review). In one human study, it was found that the treatment of severe H1N1 influenza‑related pneumonia with rapamycin and steroids improved the outcome. […] The inhalation of buformin or phenformin for influenza may be an effective novel treatment strategy that would limit the risk of systemic side-effects associated with biguanides due to the low inhaled dose. 2020-05-01
COVID-19 Clinical Trials: A Primer for the Cardiovascular and Cardio-Oncology Communities. Here we have provided a foundation for cardiovascular and cardio-oncology physicians who are on the frontline providing care to COVID-19 patients, so that they can better understand the emerging cardiovascular epidemiology of COVID-19, as well as the biological rationale for the clinical trials that are ongoing for the treatment of COVID-19 patients. 2020-05-22
Coronavirus Disease 19 (COVID-19) complicated with pneumonia in a patient with rheumatoid arthritis receiving conventional disease-modifying antirheumatic drugs. The patient was treated with antiviral agents (lopinavir/ritonavir), and treatment with cDMARDs was discontinued except hydroxychloroquine. 2020-05-04
Sustainable practice of ophthalmology during COVID-19: challenges and solutions. With no proven vaccination or treatment, infection control measures are paramount. 2020-04-30
Pharmacologic Therapy for COVID-19 Infection. I submit that attention to COVID-19 pharmacologic therapy needs similar emphasis, including identifying any existing medications that can be repurposed to treat COVID-19 patients. 2020-05-01
Challenges of COVID-19 pandemic for dermatology. COVID-19 is a challenge for the treatment of dermatologic patients, either with severe inflammatory disorders or with skin cancer. […] The consequences for systemic treatment are obvious but it will be most important to collect the clinical data for a better decision process. 2020-05-22
COVID-19 and psoriasis: Should we fear for patients treated with biologics? One of question is if psoriasis patients treated with immunomodulating and immunosuppressive drugs have to discontinue their treatment in the midst of fears for the infection and its consequences. 2020-05-22
Case Report: Hepatotoxicity Associated with the Use of Hydroxychloroquine in a Patient with Novel Coronavirus Disease (COVID-19). Hydroxychloroquine (HCQ) has been used for the treatment of novel coronavirus disease (COVID-19) cases. […] Considering the significantly increased use of HCQ during the COVID-19 pandemic, this case alerts us to the potential for HCQ to be associated with hepatotoxicity and the need to monitor liver function during HCQ therapy. 2020-04-21
Letter to the Editor: Acute hypertriglyceridemia in patients with COVID-19 receiving tocilizumab. Tocilizumab is an interleukin-6 (IL-6) receptor antibody and is progressing as a viable and promising treatment option in patients with severe coronavirus disease 2019 (COVID-19). 2020-05-12
Melatonin: Roles in influenza, Covid-19, and other viral infections. Focussing on immune regulators has treatment implications for covid-19 and other viral infections. 2020-05-19
Opioid use disorder and the COVID 19 pandemic: A call to sustain regulatory easements and further expand access to treatment. We highlight the critical roles that pharmacists have related to sustaining and advancing the changes being made in the face of the current COVID-19 pandemic to ensure that patients have more seamless and less complex access to treatment. 2020-04-24
Fast Identification of Possible Drug Treatment of Coronavirus Disease-19 (COVID-19) through Computational Drug Repurposing Study. The recent outbreak of novel coronavirus disease-19 (COVID-19) calls for and welcomes possible treatment strategies using drugs on the market. 2020-05-07
Atypical presentation of COVID-19 in a frail older person. He was given antibiotics for infection of unknown source, subsequently refined to treatment for community-acquired pneumonia. […] Despite active treatment, he deteriorated with oxygen desaturation and tachypnoea. 2020-04-30
Clinical and Autoimmune Characteristics of Severe and Critical Cases of COVID-19. Autoimmune phenomena exist in COVID-19 subjects, and the present results provide the rationale for a strategy of preventing immune dysfunction and optimal immunosuppressive therapy. 2020-05-14
Laboratory data analysis of novel coronavirus (COVID-19) screening in 2510 patients. Novel coronavirus (COVID-19) is highly infectious and requires early detection, isolation, and treatment. 2020-05-30
Current epidemiological and clinical features of COVID-19; a global perspective from China. Additionally, the origin of COVID-19 has not been determined and no specific antiviral treatment or vaccine is currently available. 2020-05-16
Suppressed T cell-mediated immunity in patients with COVID-19: A clinical retrospective study in Wuhan, China. Our findings may shed light on early warning of high risks of mortality and help early intervention and treatment of COVID-19. 2020-04-26
Prevalence and severity of corona virus disease 2019 (COVID-19): A systematic review and meta-analysis. ARDS and ACI may be the main obstacles for patients to treatment recovery. 2020-05-27
Lessons learned from 9/11: Mental health perspectives on the COVID-19 pandemic. Drawing on the 9/11 experience, we highlight effective prevention measures, likely short and long-term treatment needs, vulnerable subgroups, and important points of divergence between 9/11 and the COVID-19 pandemic. […] Mental health monitoring, early identification of at-risk individuals, and treatment irrespective of financial barriers are essential for minimizing chronic distress. 2020-05-19
Case report of chloroquine therapy and hypoglycaemia in type 1 diabetes: What should we have in mind during the COVID-19 pandemic? A type 1 diabetes patient experienced remission associated with chloroquine therapy while travelling to a malaria-endemic area. 2020-05-27
COVID-19 in a MS patient treated with ocrelizumab: does immunosuppression have a protective role? However, it has been speculated that overactive immune response could drive clinical deterioration and, based on this hypothesis, several immunosuppressants are currently being tested as potential treatment for COVID-19. […] This report supports the putative role of immunosuppressive therapy in COVID-19 affected patients. 2020-05-26
Prevention and Treatment of Venous Thromboembolism Associated with Coronavirus Disease 2019 Infection: A Consensus Statement before Guidelines. Concomitant venous thromboembolism (VTE), a potential cause of unexplained deaths, has been frequently reported in COVID-19 cases, but its management is still challenging due to the complexity between antithrombotic therapy and coagulation disorders. 2020-05-06
Geographical Accessibility to Glucose-6-Phosphate Dioxygenase Deficiency Point-of-Care Testing for Antenatal Care in Ghana. Glucose-6-Phosphate Dehydrogenase (G6PD) deficiency screening test is essential for malaria treatment, control, and elimination programs. […] G6PD deficient individuals are at high risk of severe hemolysis when given anti-malarial drugs such as primaquine, quinine, other sulphonamide-containing medicines, and chloroquine, which has recently been shown to be potent for the treatment of coronavirus disease (COVID-19). […] Given the challenges associated with G6PD deficiency, it would be essential to improve access to G6PD deficiency POC testing to facilitate administration of sulphadoxine-pyrimethamine to pregnant women, full implementation of the malaria control program in Ghana, and treatment of COVID-19 patients with chloroquine in malaria-endemic countries. 2020-05-29
Novel Coronavirus: Current Understanding of Clinical Features, Diagnosis, Pathogenesis, and Treatment Options. The purpose of this review is to provide a comprehensive update on the pathogenesis, clinical aspects, diagnosis, challenges and treatment of SARS-CoV-2 infections. 2020-05-29
[Explore the Optimal Resolvent of Medical Needs and Mental Health for Patients with Lung Cancer during Epidemic Novel Coronavirus Pneumonia]. The aims were to investigate medical needs of lung cancer patients and their mental health status during the epidemic periods, so as to provide rational recommendations for subsequent diagnosis and treatment. […] Of the 368 patients, 18 patients were excluded as they didn’t receive anti-tumor treatment, and 350 patients were included in the final analysis. 229 cases were treated with oral targeted drugs, and 121 cases were treated with chemotherapy or immunotherapy. […] 41.3% of patients treated with intravenous chemotherapy or immunotherapy experienced treatment discontinuation, and the proportion of treatment discontinuation in chemotherapy or immunotherapy was higher than those treated with oral targeted drugs (21.0%). […] 26.6%-28.9% of patients have changed their treatment plans through online consultation. 2020-05-16
Systematic rapid “living” review on rehabilitation needs due to covid-19: update to march 31st 2020. A systematic search on PubMed, Pedro and Google Scholar was performed using the search terms: “Covid-19”, “Coronavirus”, “severe acute respiratory syndrome coronavirus 2”, “rehabilitation”, “physical therapy modalities”, “exercise”, “occupational therapy”, and “late complications”. 2020-04-22
Coronavirus disease 2019: reassembly attack of coronavirus. There is currently no effective treatment or approved vaccine, so isolating the source of infection and blocking the routes of transmission is important. 2020-04-22
COVID-19: Facts, Cultural Considerations, and Risk of Stigmatization. Timely and appropriate public health interventions addressing cultural impact and risk for stigmatization along with proper screening, treatment, and follow up for affected individuals and close contacts can reduce the number of infections, serious illness, and deaths. 2020-05-27
Drugs supply and pharmaceutical care management practices at a designated hospital during the COVID-19 epidemic. Drugs are the main treatment of COVID-19 patients. […] According to COVID-19 prevention and control policy and requirements, combined with series of diagnosis and treatment plans, pharmacists in the first provincial-level COVID-19 diagnosis and treatment unit in Jilin Province in Northeast China have established the management practices of drug supply and pharmaceutical care from four aspects: personnel, drugs supply management, off-label drug use management and pharmaceutical care. […] So far, no nosocomial infections and medication errors have occurred, which has stabilized the mood of the staff and boosted the pharmacists’ confidence in fighting the epidemic. […] For the treatment of COVID-19, pharmacists conducted adverse reaction monitoring and participated in the multidisciplinary consultation of COVID-19. 2020-04-24
Coronavirus Disease 2019 Pneumonia in Immunosuppressed Renal Transplant Recipients: A Summary of 10 Confirmed Cases in Wuhan, China. Immunosuppressant reduction and low-dose methylprednisolone therapy. […] After a longer time of virus shedding (28.4 ± 9.3 vs 12.2 ± 4.6 d in the control group) and a longer course of illness (35.3 ± 8.3 vs 18.8 ± 10.5 d in the control group), nine of the 10 transplant patients recovered successfully after treatment. […] Findings from this small group of cases may have important implications for the treatment of COVID-19 pneumonia in immunosuppressed populations. […] Immunosuppressed transplant recipients with coronavirus disease 2019 infection had more severe pneumonia, but most of them still achieved a good prognosis after appropriate treatment. 2020-05-28
Areas of academic research with the impact of COVID-19. Hence, there is an urgent requirement for conducting academic research on several aspects of this highly contagious disease, to find effective means of containment and treatment of the disease, for now, and in future. 2020-04-24
Clinical features and multidisciplinary treatment outcome of COVID-19 pneumonia: A report of three cases. In the current paper, we describe our successful treatment of three COVID-19 pneumonia patients cases including severe cases and cases with mortality risk factors. 2020-04-24
The anti-viral facet of anti-rheumatic drugs: Lessons from COVID-19. Several efforts are currently made to find a treatment for COVID-19 patients. […] The anti-viral aspect of immunosuppressants towards a variety of viruses has been known since long time and it is herein discussed in the view of searching for a potential treatment for SARS-CoV-2 infection. 2020-04-24
A sporadic COVID-19 pneumonia treated with extracorporeal membrane oxygenation in Tokyo, Japan: A case report. He was successfully treated in the intensive care unit with mechanical ventilation and extracorporeal membrane oxygenation for respiratory support; and antiretroviral treatment with lopinavir/ritonavir. 2020-04-24
Viral load dynamics and disease severity in patients infected with SARS-CoV-2 in Zhejiang province, China, January-March 2020: retrospective cohort study. Epidemiological, clinical, and laboratory characteristics and treatment and outcomes data were obtained through data collection forms from electronic medical records, and the relation between clinical data and disease severity was analysed. 3497 respiratory, stool, serum, and urine samples were collected from patients after admission and evaluated for SARS-CoV-2 RNA viral load. 2020-04-24
Early Description of Coronavirus 2019 Disease in Kidney Transplant Recipients in New York. Our current treatment protocol appears to be associated with favorable outcomes, but longer follow-up of a larger cohort of patients is needed. 2020-05-30
Perspectives for repurposing drugs for the coronavirus disease 2019. In the absence of approved marketed drugs against coronaviruses, the treatment and management of this novel CoV disease (COVID-19) worldwide is a challenge. 2020-05-06
Extracorporeal Membrane Oxygenation in the Treatment of Severe Pulmonary and Cardiac Compromise in COVID-19: Experience with 32 patients. As COVID-19 cases surge worldwide, an urgent need exists to enhance our understanding of the role of extracorporeal membrane oxygenation (ECMO) in the management of severely ill patients with COVID-19 who develop acute respiratory and cardiac compromise refractory to conventional therapy. […] Adjunctive medication in the surviving patients while on ECMO was as follows: 4 of 5 survivors received intravenous steroids, 3 of 5 survivors received antiviral medications (Remdesivir), 2 of 5 survivors were treated with anti-interleukin-6-receptor monoclonal antibodies (Tocilizumab or Sarilumab), and 1 of 5 survivors received hydroxychloroquine.An analysis of 32 COVID-19 patients with severe pulmonary compromise supported with ECMO suggests that ECMO may play a useful role in salvaging select critically ill patients with COVID-19. 2020-05-15
The suspected SARS-Cov-2 infection in a Charcot-Marie-Tooth patient undergoing postsurgical rehabilitation: the value of telerehabilitation for evaluation and continuing treatment. The diagnosis was established through a remote interaction with the patient after early discharge from outpatient therapy due to upcoming traveling restrictions. 2020-05-26
[COVID-19 in hospitalized children and adolescents]. The clinical knowledge about the course, complications and treatment of COVID-19 in children and adolescents is so far limited. 2020-04-24
Understanding SARS-CoV-2: Genetic Diversity, Transmission and Cure in Human. It will help in designing a probiotic-based diet for modulation of the gut microbiome, and that could be another plausible prophylactic treatment option. […] Hence, the experiences from the clinical intervention for that region should be considered in control and treatment strategies. 2020-04-24
Depriving Iron Supply to the Virus Represents a Promising Adjuvant Therapeutic Against Viral Survival. For example, treatment with iron chelator deferiprone has been shown to prolong the survival of acquired immunodeficiency syndrome (AIDS) patients. 2020-04-24
The clinical data from 19 critically ill patients with coronavirus disease 2019: a single-centered, retrospective, observational study. The objectives of this study were to analyze the clinical features of coronavirus disease 2019 (COVID-19) and evaluate the diagnosis and treatment. 2020-04-24
Age-related rhesus macaque models of COVID-19. Rhesus macaque models infected with SARS-CoV-2 provided insight into the pathogenic mechanism and facilitated the development of vaccines and therapeutics against SARS-CoV-2 infection. 2020-05-19
Multicenter initial guidance on use of antivirals for children with COVID-19/SARS-CoV-2. The panel suggests a decision-making framework for antiviral therapy that weighs risks and benefits based on disease severity as indicated by respiratory support needs, with consideration on a case-by-case basis of potential pediatric risk factors for disease progression. […] Antiviral therapy for COVID-19 is not necessary for the great majority of pediatric patients. 2020-05-14
Knowledge, Perceptions, and Attitude of Egyptians Towards the Novel Coronavirus Disease (COVID-19). If a vaccine or a treatment is approved, we recommend a government control over its use to preserve the rights of the vulnerable and needy groups. 2020-05-01
Managing childhood allergies and immunodeficiencies during respiratory virus epidemics - the 2020 COVID-19 pandemic. While the world is facing an unprecedented pandemic with COVID-19, patients with chronic diseases need special attention and if warranted adaptation of their regular treatment plan. […] Optimal disease control of allergic, asthmatic and immunodeficient children should be sought according to usual treatment guidelines. 2020-05-20
A Case of SARS-CoV-2-pneumonia with successful antiviral therapy in a 77-year-old male with heart transplant. In this report, we present a 77-year old patient with a heart transplant under relevant immunosuppressive therapy who was tested positive for SARS-CoV-2 after several days of dyspnoea, dry cough and light general symptoms. […] The patient received an antiviral therapy with hydroxychloroquine showing no further deterioration of the clinical state. 2020-04-22
Respiratory Support in Novel Coronavirus Disease (COVID-19) Patients, with a Focus on Resource-Limited Settings. Key messages include that supplemental oxygen is a first essential step for the treatment of severe COVID-19 patients with hypoxemia and should be a primary focus in resource-limited settings where capacity for invasive ventilation is limited. 2020-04-22
[The choices in CoViD-19’s time.] In the case of CoViD-19, we must rely on professionals: it is not the time for the anticipated treatment plan, for self-determination. 2020-04-24
[Ethical, deontologic and legal considerations about SIAARTI Document “Clinical ethics recommendations for the allocation of intensive care treatments, in exceptional, resource-limited circumstances”.] The document, which aims to propose treatment decision-making criteria in the face of exceptional imbalances between health needs and available resources, has produced strong reactions, within the medical-scientific community, in the academic world, and in the media. 2020-04-24
[Between intensive care and palliative care at the time of CoViD-19.] The shortage of intensive care units (ICU) beds and ventilators for the treatment of patients with severe respiratory failure produced angst in the clinicians/intensivists who have to decide which patients admit to ICU and in which patients to implement palliative care. […] The patients not admitted to ICU due to clinical reasons and advanced stage diseases should receive a high quality palliative care, to obtain a good symptoms control (mainly dyspnea, anxiety and delirium) and to implement palliative sedation at the end of life. 2020-04-24
[Vitamin D and coronavirus: a new field of use?] At the end of the bibliographic survey there is the current absence of evidence of efficacy in favor of vitamin D in the treatment of coronavirus infection in its various expressions. 2020-04-27
Anosmia as a prominent symptom of COVID-19 infection. Due to the lack of current effective treatment and vaccine for COVID-19, screening, rapid diagnosis and isolation of the patients are essential (1, 2). 2020-04-22
Presenting Characteristics, Comorbidities, and Outcomes Among 5700 Patients Hospitalized With COVID-19 in the New York City Area. Clinical outcomes during hospitalization, such as invasive mechanical ventilation, kidney replacement therapy, and death. […] During hospitalization, 373 patients (14.2%) (median age, 68 years [IQR, 56-78]; 33.5% female) were treated in the intensive care unit care, 320 (12.2%) received invasive mechanical ventilation, 81 (3.2%) were treated with kidney replacement therapy, and 553 (21%) died. 2020-05-01
The emergence of a novel coronavirus (SARS-CoV-2) disease and their neuroinvasive propensity may affect in COVID-19 patients. All these indicate that more detailed criteria are needed for the treatment and the prevention of SARS-CoV-2 infected patients. 2020-04-29
The Prevalence, Characteristics, and Prevention Status of Skin Injury Caused by Personal Protective Equipment Among Medical Staff in Fighting COVID-19: A Multicenter, Cross-Sectional Study. Only 17.7% of respondents took prevention and 45.0% of skin injuries were treated. Innovation: This is the first cross-sectional survey to understand skin injuries in medical staff caused by PPE, which is expected to be a benchmark. Conclusion: The skin injuries among medical staff are serious, with insufficient prevention and treatment. 2020-05-01
Logic in the time of coronavirus. Emerging infectious diseases by their nature, pose new challenges to the diagnostic-treatment-control nexus, and push our concepts of causality beyond the limits of the conventional Koch-Henle approach to aetiology. 2020-05-29
Knowledge and Perceptions of COVID-19 Among Health Care Workers: Cross-Sectional Study. A poor understanding of the disease among health care workers (HCWs) may result in delayed treatment and result in the rapid spread of the infection. 2020-05-06
Anti-SARS-CoV-2 virus antibody levels in convalescent plasma of six donors who have recovered from COVID-19. CP was also utilized for the treatment of one severe COVID-19 patient. 2020-05-06
Chloroquine Dosing Recommendations for Pediatric COVID-19 Supported by Modeling and Simulation. As chloroquine (CHQ) is part of the Dutch Centre for Infectious Disease Control coronavirus disease 2019 (COVID-19) experimental treatment guideline, pediatric dosing guidelines are needed. 2020-05-21
Risks of ACE Inhibitor and ARB Usage in COVID-19: Evaluating the Evidence. The findings in animals are inconsistent with respect to an increase in ACE2 expression in response to treatment with ACEIs or ARBs. 2020-05-11
Systemic immunosuppressive therapy for inflammatory skin diseases in children: Expert consensus-based guidance for clinical decision-making during the COVID-19 pandemic. A survey was distributed to an expert panel of 37 pediatric dermatologists on the PDCRTF to assess expert opinion and current practice related to three primary domains of systemic therapy: initiation, continuation, and laboratory monitoring. […] In asymptomatic patients, continuing therapy was the most popular choice across all medications queried. […] The ultimate decision regarding initiation, continuation, and laboratory monitoring of immunosuppressive therapy during the pandemic requires careful deliberation, consideration of the little evidence available, and discussion with families. […] Consideration of an individual’s adherence to COVID-19 preventive measures, risk of exposure, and the potential severity if infected must be weighed against the dermatological disease, medication, and risks to the patient of tapering or discontinuing therapies. 2020-05-16
Early Self-Proning in Awake, Non-intubated Patients in the Emergency Department: A Single ED’s Experience During the COVID-19 Pandemic. Proning has become a standard treatment in the management of patients with ARDS who have difficulty achieving adequate oxygen saturation. 2020-05-15
Scientific research progress of COVID-19/SARS-CoV-2 in the first five months. Here, we summarized the current known knowledge regarding epidemiological, pathogenesis, pathology, clinical features, comorbidities and treatment of COVID-19/ SARS-CoV-2 as reference for the prevention and control COVID-19. 2020-05-07
High incidence of venous thromboembolic events in anticoagulated severe COVID-19 patients. We performed a retrospective study in 2 French intensive care units (ICU) where CDU is performed as a standard of care. 2020-05-27
Complex Immune Dysregulation in COVID-19 Patients with Severe Respiratory Failure. SARS-CoV-2 patient plasma inhibited HLA-DR expression, and this was partially restored by the IL-6 blocker Tocilizumab; off-label Tocilizumab treatment of patients was accompanied by increase in circulating lymphocytes. 2020-04-24
Recent progress and challenges in drug development against COVID-19 coronavirus (SARS-CoV-2) - an update on the status. Currently, no specific medication is recommended to treat COVID-19 patients. […] In the current review, we summarize the existing state of knowledge about COVID-19, available medications, and treatment options. […] Favilavir is an antiviral drug that is approved in Japan for common influenza treatment and is now approved to treat symptoms of COVID-19 in China. […] Moreover, Chloroquine and hydroxychloroquine, drugs used to treat malaria and arthritis, respectively, were recommended by the National Health Commission of the People’s Republic of China for treatment of COVID-19. […] Presently, chloroquine and hydroxychloroquine are under investigation by the US Food and Drug Administration (FDA) as a treatment for COVID-19. 2020-05-26
COVID-19 Diagnostic and Management Protocol for Pediatric Patients. Guidelines developed by experts can help all practitioners standardize their attitudes and improve the treatment of COVID-19. 2020-04-27
Challenges and Priorities in Responding to COVID-19 in Inpatient Psychiatry. Nuanced considerations of five contingency planning strategies in response to COVID-19 are described, including COVID-19-specific precautions, visitor restrictions, physician workforce considerations, operational adjustments, and group therapy changes. 2020-04-23
Emerging SARS-CoV-2 mutation hot spots include a novel RNA-dependent-RNA polymerase variant. To date, several drugs targeting RdRp enzymes are being employed for SARS-CoV-2 infection treatment. 2020-04-27
The unsynchronized changes of CT image and nucleic acid detection in COVID-19: reports the two cases from Gansu, China. The CT image is used to assess the disease progress, whereas the continued two times of negative results from SARS-CoV-2 nucleic acid detection had been considered as a criterion for ending antiviral treatment. […] We compared the two COVID-19 cases with similar backgrounds and CT image repeated intervals under treatment. 2020-04-24
Is GSK3β a molecular target of chloroquine treatment against COVID-19? The recent clinical trial reports pertaining to the efficacy of chloroquine and hydroxychloroquine against COVID-19 albeit yet to be validated with larger clinical trials, have sparked much interest globally to evaluate whether this anti-malarial drug can be repurposed for the treatment of COVID-19. […] Based on our data obtained from an animal infection model of melioidosis (a disease caused by the bacteria Burkholderia pseudomallei), treatment with chloroquine can result in the phosphorylation and consequent inhibition of glycogen synthase kinase-3β (GSK3β). 2020-05-08
Neuropsychiatric adverse events of chloroquine: a real-world pharmacovigilance study using the FDA Adverse Event Reporting System (FAERS) database. In late March and early April 2020, the antimalarial drug, chloroquine, has been approved as an emergency treatment for the coronavirus disease 2019 (COVID-19) in the United States and in Europe. […] Although infrequent, neuropsychiatric symptoms have been reported in patients who received chloroquine for the treatment of malaria or autoimmune diseases. […] Current pharmacovigilance study results did not suggest any potential link between the use of chloroquine and an increased risk of suicide, psychosis, confusion, and agitation, which would be informative during the emergency use of chloroquine for the treatment of COVID-19. 2020-05-22
Prevalence of malnutrition and analysis of related factors in elderly patients with COVID-19 in Wuhan, China. The prevalence of malnutrition in elderly patients with COVID-19 was high, and nutritional support should be strengthened during treatment, especially for those with diabetes mellitus, low calf circumference, or low albumin. 2020-04-29
Epidemiology, genome, and clinical features of the pandemic SARS-CoV-2: a recent view. Although much is still unknown about SARS-CoV-2, the scientific research is moving at an unprecedented pace towards understanding the nature, effective control, prevention and treatment of SARS-CoV-2. […] Unfortunately, no effective treatment or therapeutic drug is available for the disease; only supportive treatment and classical intervention measures are available for confronting the SARS-CoV-2 pandemic. 2020-04-26
Review on the global epidemiological situation and the efficacy of chloroquine and hydroxychloroquine for the treatment of COVID-19. Covid-19 is so new that there is currently no specific vaccine or treatment. […] In vitro tests are also being conducted to assess the efficacy of chloroquine and hydroxychloroquine for the treatment of this epidemic, which is considered a pandemic by the WHO. 2020-04-26
Efficacy of glutathione therapy in relieving dyspnea associated with COVID-19 pneumonia: A report of 2 cases. No published treatment to date has been shown to adequately control the inflammation and respiratory symptoms associated with COVID-19, apart from oxygen therapy and assisted ventilation. […] We evaluated the effects of using high dose oral and/or IV glutathione in the treatment of 2 patients with dyspnea secondary to COVID-19 pneumonia. […] Oral and IV glutathione, glutathione precursors (N-acetyl-cysteine) and alpha lipoic acid may represent a novel treatment approach for blocking NFKappaB and addressing “cytokine storm syndrome” and respiratory distress in patients with COVID-19 pneumonia. 2020-04-25
Management of Locally Advanced Rectal Cancer During The COVID-19 Pandemic: A Necessary Paradigm Change at Memorial Sloan Kettering Cancer Center. Previous to the pandemic we commonly utilized total neoadjuvant therapy (TNT) with a strong preference for long course chemoradiation (LCCRT). […] In the setting of the ongoing pandemic we now mandate short course radiation therapy (SCRT). 2020-04-26
[Handling of COVID-19 in the emergency department : Field report of the emergency ward of the University Hospital Münster]. The general and special emergency management was optimized for the efficient treatment of COVID-19-positive patients and the staff were trained in the use of protective equipment. 2020-04-25
[Renin-Angiotensin-System (RAS) and COVID-19 - On The Prescription of RAS Blockers]. In this context, it was suspected that therapy with RAS blockers might promote transmission and complications of COVID-19 by upregulation of ACE2 expression. 2020-05-22
[Position Paper for the State of the Art Application of Respiratory Support in Patients with COVID-19 - German Respiratory Society]. Against the background of the pandemic caused by infection with the SARS-CoV-2, the German Society for Pneumology and Respiratory Medicine (DGP e.V.), in cooperation with other associations, has designated a team of experts in order to answer the currently pressing questions about therapy strategies in dealing with COVID-19 patients suffering from acute respiratory insufficiency (ARI). […] Supply continuum for the treatment of ARIKey points have been highlighted as core statements and significant observations. […] This distinction can be taken into consideration in the differential instrumentation in the therapy of ARI.The assessment of the extent of ARI should be carried out by an arterial or capillary blood gas analysis under room air conditions and must include the calculation of the oxygen supply (measured from the variables of oxygen saturation, the Hb value, the corrected values of the Hüfner number and the cardiac output). […] If the specifications for protective equipment (eye protection, FFP2 or FFP-3 mask, gown) are adhered to, inhalation therapy, nasal high-flow (NHF) therapy, CPAP therapy or NIV can be carried out according to the current state of knowledge without increased risk of infection to the staff. […] In this situation, CPAP/NIV therapy can be administered under use of a mouth and nose mask or a respiratory helmet as therapy escalation, as long as the criteria for endotracheal intubation are not fulfilled.In acute hypoxemic respiratory insufficiency, NIV should be performed in an intensive care unit or in a comparable unit by personnel with appropriate expertise. 2020-04-23
Solid organ transplantation programs facing lack of empiric evidence in the COVID-19 pandemic: A By-proxy Society Recommendation Consensus approach. Solid organ transplantation represents a field with a high demand on staff, intensive care units, and follow-up facilities. 2020-05-10
Chloroquine and Hydroxychloroquine for the Prevention or Treatment of Novel Coronavirus Disease (COVID-19) in Africa: Caution for Inappropriate Off-Label Use in Healthcare Settings. Hydroxychloroquine is mainly used as a therapy for autoimmune diseases. […] However, the efficacy and safety of CQ/HCQ for the treatment of COVID-19 remains to be defined. […] Indiscriminate promotion and widespread use of CQ/HCQ have led to extensive shortages, self-treatment, and fatal overdoses. 2020-04-23
Rapid and Sensitive Detection of anti-SARS-CoV-2 IgG, Using Lanthanide-Doped Nanoparticles-Based Lateral Flow Immunoassay. Thus, this assay can achieve rapid and sensitive detection of anti-SARS-CoV-2 IgG in human serum and allow positive identification in suspicious cases; it can also be useful for monitoring the progression COVID-19 and evaluating patients’ response to treatment. 2020-05-21
Diagnosis, Prevention, and Treatment of Thromboembolic Complications in COVID-19: Report of the National Institute for Public Health of the Netherlands. The National Institute for Public Health of the Netherlands asked a group of Radiology and Vascular Medicine experts to provide guidance for the imaging workup and treatment of these important complications. 2020-04-23
Association of Renin-Angiotensin System Inhibitors With Severity or Risk of Death in Patients With Hypertension Hospitalized for Coronavirus Disease 2019 (COVID-19) Infection in Wuhan, China. COVID-19 was confirmed by real-time reverse transcription-polymerase chain reaction and epidemiologic, clinical, radiologic, laboratory, and drug therapy data were analyzed in all patients. 2020-04-30
[Medication and comedication in COVID-19 patients]. This paper discusses the possible effects of comedication on COVID-19 and the current treatment options for this infection. […] Currently, chloroquine and remdesivir are possible treatment options. […] There is no sound evidence for either treatment. […] The treatment should be reconsidered in the event of side effects and when inferior medication for comorbidity must be prescribed because of possible interactions. […] Supportive care is at present the mainstay of the treatment. 2020-04-28
Challenges of intensive care and anesthesiology related to COVID-19 pandemic. Practical considerations These challenges are the most critical in the field of intensive treatment and anesthesiology. […] One of the most important prerequisites of effective critical care treatment is preserving the involved healthcare workers from the infection, by providing them with detailed practical advices on the preventive measures and treatment strategies. 2020-04-27
Diagnostic consideration and bedside estimation of the prognosis in COVID-19 patients In addition to the epidemiologic interventions aiming the deceleration of the outbreak, the early identification and the correct hospital treatment remain key issues since these may influence mortality. 2020-04-27
Pharmacological options in treating SASR-CoV-2 infection/COVID-19 There is currently no proven effective therapy for COVID-19. […] Here we discuss the drugs most investigated for the treatment of the disease. […] However, due to the severe healthcare effects of the pandemic and the potentially fatal outcome of COVID-19 patients treated in the intensive care units, their off-label use should none-the-less be considered. 2020-04-27
Practical aspects of anesthetic and perioperative care for COVID-19 patients The purpose of this summary is to present the practical aspects of anesthetic and perioperative care for patients requiring surgical treatment. 2020-04-27
Airway management of coronavirus-infected patients The best treatment is early endotracheal intubation and invasive mechanical ventilation. 2020-05-04
Organ replacement therapy and life-supporting treatment modalities in critically ill COVID-19 patients In recent years, CytoSorb-haemoperfusion to remove cytokines has shown promising results in the treatment of septic shock. 2020-04-27
Prevention and therapy of COVID-19 via exogenous estrogen treatment for both male and female patients. In animal experiments, estrogen treatment silences the inflammatory reactions and decreases virus titers leading to improved survival rate; it seems to be an ideal prevention and therapy against COVID-19. […] We should overcome the widespread reluctance to estrogen therapy as we have a unique estrogen formula; conjugated estrogens, or conjugated equine estrogens available under the brand name of Premarin deriving from natural sources. 2020-04-28
Incidence of Adverse Drug Reactions in COVID-19 Patients in China: An Active Monitoring Study by Hospital Pharmacovigilance System. Together, the incidence of ADRs was significantly high during the treatment period. […] Moreover, the active monitoring of the CHPS system reflected ADRs during COVID-19 treatment in the real world, which provided reference for safe medication in the clinic. 2020-05-26
Drug Development and Medicinal Chemistry Efforts toward SARS-Coronavirus and Covid-19 Therapeutics. There is no effective vaccine or approved drug treatment against COVID-19 and other pathogenic coronaviruses. 2020-05-07
Role of duties related to COVID-19 suspected, probable and confirmed fatality cases In this article, besides providing a summary of literature, we would also like to make practical recommendations which may increase the safety of healthcare providers participating in the treatment or pathological duties with COVID-19 suspected, probable and confirmed cases. 2020-04-27
COVID-19 in cardiac arrest and infection risk to rescuers: A systematic review. There may be a risk of COVID-19 transmission to rescuers delivering treatment for cardiac arrest. […] The aim of this review was to identify the potential risk of transmission associated with key interventions (chest compressions, defibrillation, cardiopulmonary resuscitation) to inform international treatment recommendations. […] Data from manikin studies indicates that donning of personal protective equipment delays treatment delivery. 2020-05-20
Vaporization, bioactive formulations and a marine natural product: different perspectives on antivirals. This article examines three aspects of antivirals, such as hydroxychloroquine, chloroquine, and remdesvir, as they might relate to the treatment of a viral infection such as COVID-19: (i) the use of vaporization for the delivery of antivirals, with the bulk constituents having mild antiviral efficacy; (ii) the application of a marine natural product extract as opposed to a single molecule as an antiviral agent; and (iii) a counter intuitive approach to formulation that is, in part, based on delivering multiple species that fall into three categories: building blocks for the virus to accelerate replication; an energy source for the infected cell to boost its immune response; and the species that antagonize or provide toxicity to the virus. 2020-04-28
Characteristics, Symptom Management, and Outcomes of 101 Patients With COVID-19 Referred for Hospital Palliative Care. Hospital palliative care is an essential part of the COVID-19 response but data are lacking. […] We identified symptom burden, management, response to treatment, and outcomes for a case series of 101 inpatients with confirmed COVID-19 referred to hospital palliative care. […] Patients spent a median [IQR] of 2 [1-4] days under the palliative care team, who made 3 [2-5] contacts across patient, family, and clinicians. […] At March 30, 2020, 75 patients had died; 13 been discharged back to team, home, or hospice; and 13 continued to receive inpatient palliative care. […] Palliative care is an essential component to the COVID-19 response, and teams must rapidly adapt with new ways of working. […] An international minimum data set for palliative care would accelerate finding answers to new questions as the COVID-19 pandemic develops. 2020-05-11
COVID-19 pathophysiology: A review. Lack of targeted therapy continues to be a problem. 2020-05-31
COVID-19 Drug Discovery Using Intensive Approaches. While novel vaccines and drugs that target SARS-CoV-2 are under development, this review provides information on therapeutics which are under clinical trials or are proposed to antagonize SARS-CoV-2. 2020-04-27
Fear and Practice Modifications among Dentists to Combat Novel Coronavirus Disease (COVID-19) Outbreak. A large number of dentists (90%) were aware of recent changes in the treatment protocols. […] However, execution of amended treatment protocol was recorded as 61%. […] A number of dental practices have either modified their services according to the recommended guidelines to emergency treatment only or closed down practices for an uncertain period. 2020-04-29
Can Nanotechnology and Materials Science Help the Fight against SARS-CoV-2? While great resources are understandably being dedicated to treatment and diagnosis, more efforts could be dedicated to limit the virus spread. 2020-05-23
COVID-19: A Recommendation to Examine the Effect of Mouthrinses with β-Cyclodextrin Combined with Citrox in Preventing Infection and Progression. If chlorhexidine, a usual component of mouth rinse, is not efficient to kill SARS-CoV-2, the use of a mouth rinses and/or with local nasal applications that contain β-cyclodextrins combined with flavonoids agents, such as Citrox, could provide valuable adjunctive treatment to reduce the viral load of saliva and nasopharyngeal microbiota, including potential SARS-CoV-2 carriage. 2020-05-23
From Donor to Patient: Collection, Preparation and Cryopreservation of Fecal Samples for Fecal Microbiota Transplantation. Technical and logistical issues arise when establishing such a non-standardized treatment into clinical practice with safety and proper governance. 2020-04-24
Pharmacological Therapeutics Targeting RNA-Dependent RNA Polymerase, Proteinase and Spike Protein: From Mechanistic Studies to Clinical Trials for COVID-19. This constant transmission of a novel coronavirus and its ability to spread from human to human have prompted scientists to develop new approaches for treatment of COVID-19. […] Here, we systemically discuss the pharmacological therapeutics targeting RNA-dependent RNA polymerase (RdRp), proteinase and S protein for treatment of SARS-CoV-2 infection. […] In addition, we will discuss the viability and challenges in targeting RdRp and proteinase, and application of natural product quinoline and its analog chloroquine for treatment of coronavirus infection. 2020-05-23
Management of Traumatic Spinal Fracture in the Coronavirus Disease 2019 Situation. This article aims to propose a treatment algorithm for the management of traumatic spine fracture during the COVID-19 pandemic. 2020-04-24
Early chest computed tomography to diagnose COVID-19 from suspected patients: A multicenter retrospective study. The combinations with GGOs could be useful in the identification and differential diagnosis of COVID-19, alerting clinicians to isolate patients for prompt treatment and repeat RT-PCR tests until the end of incubation. 2020-04-27
Oleoylethanolamide, A Bioactive Lipid Amide, as A Promising Treatment Strategy for Coronavirus/COVID-19. With the emergence of the COVID-19 virus and considering the lack of effective pharmaceutical treatment for it, there is an urgent need to identify safe and effective drugs or potential adjuvant therapy in this regard. 2020-04-26
Point of care and intensive care lung ultrasound: A reference guide for practitioners during COVID-19. Ultrasound, although not used in the diagnosis of COVID-19 may be utilised by practitioners at the point of care (POC) or on the intensive care units (ITUs) where rapid assessment of the lung condition may be required. 2020-04-27
Safety signals for QT prolongation or Torsades de Pointes associated with azithromycin with or without chloroquine or hydroxychloroquine. Risks of treatment include QT segment prolongation, Torsades de Pointes (TdP), and death. 2020-04-27
Keeping people with epilepsy safe during the Covid-19 pandemic. The recommendations focus on administration of as much care as possible at home to keep people with epilepsy out of health care facilities, where they are likely to encounter COVID-19 (including strategies for rescue therapy), as well as minimization of risk of seizure exacerbation through adherence, and through ensuring a regular supply of medication. 2020-04-24
Translating IL-6 biology into effective treatments. To mark the tenth anniversary of anti-IL-6 receptor therapy worldwide, we discuss the history of research into IL-6 biology and the development of therapies that target IL-6 signalling, including the successes and challenges and with an emphasis on rheumatic diseases. 2020-05-29
[Recommendations on antithrombotic treatment during the COVID-19 pandemic. Position statement of the Working Group on Cardiovascular Thrombosis of the Spanish Society of Cardiology]. However, there is very scarce information on the management of thrombotic risk, coagulation disorders, and anticoagulant therapy. […] This article by the Working Group on Cardiovascular Thrombosis of the Spanish Society of Cardiology aims to summarize the available information and to provide a practical approach to the management of antithrombotic therapy. 2020-04-24
SARS-COV-2 infection (coronavirus disease 2019) for the gastrointestinal consultant. Many of the medications used for treatment of COVID-19 can also be associated with GI symptoms or liver injury and can be included in the differential diagnosis in these patients. 2020-04-27
[Treatment of primary and metastatic peritoneal tumors in the Covid-19 pandemic Proposals for prioritization from the RENAPE and BIG-RENAPE groups]. This is particularly so for peritoneal neoplastic diseases, for which curative treatment mobilizes substantial personnel, operating room and intensive care resources. […] It is desirable to prioritize disease conditions for which cytoreduction surgery with or without associated hyperthermic intraoperative peritoneal chemotherapy (HIPEC) is the gold-standard treatment, and for which systemic chemotherapy cannot be a temporary or long-term alternative: pseudomyxoma peritonei, resectable malignant peritoneal mesotheliomas, peritoneal metastases of colorectal origin if they are resectable and unresponsive to systemic chemotherapy after up to 12 courses, first-line ovarian carcinomatosis if resectable or in interval surgery after at most six courses of systemic chemotherapy. 2020-04-24
Coronavirus (COVID-19): A Review of Clinical Features, Diagnosis, and Treatment. This review will introduce a general overview of coronavirus and describe the clinical features, evaluation, and treatment of COVID-19 patients. 2020-04-27
A Bibliometric Analysis of COVID-19 Research Activity: A Call for Increased Output. Observational studies and therapeutic trials pertaining to COVID-19 are essential for assessing pathogenic characteristics and developing novel treatment options. 2020-04-27
Dental care during the coronavirus disease 2019 (COVID-19) outbreak: operatory considerations and clinical aspects. The protocol is designed for a hospital setting and includes considerations related to dental treatment in both healthy subjects and those suspected or diagnosed with COVID-19. 2020-04-27
Guidance for anti-VEGF intravitreal injections during the COVID-19 pandemic. Other important measures include triaging of patients to identify those at the greatest risk of irreversible vision loss and prioritization of treatment visits over monitoring visits where possible. […] In order to limit patient exposure, ophthalmologists should refrain from using treatment regimens that require frequent monitoring. 2020-05-21
Analysis of the susceptibility to COVID-19 in pregnancy and recommendations on potential drug screening. When it comes to treatment, specific drugs for COVID-19 have not been found at present, and taking old drugs for new use in treating COVID-19 has become an emergency method for the pandemic. 2020-05-01
[EMCAM (Multiple Sclerosis Autonomous Community of Madrid) document for the management of patients with multiple sclerosis during the SARS-CoV-2 pandemic]. This evidence, together with the experience of the authors in the management of patients with multiple sclerosis during the pandemic, will make it possible to offer some proposals for the treatment and follow-up of patients in this epidemiological context. […] After the literature search and our experience in the management of patients, a number of proposals for treatment are established for each drug, which must necessarily be individualised for each patient, since, in these exceptional circumstances, their peculiarities can affect the prognosis. 2020-04-28
Direct oral anticoagulant plasma levels’ striking increase in severe COVID-19 respiratory syndrome patients treated with antiviral agents: The Cremona experience. A series of patients managed in the Cremona Thrombosis Center were admitted at Cremona Hospital for SARS-CoV-2 and started antiviral drugs without stopping DOAC therapy. […] Plasma samples for DOAC measurement were collected 2to 4 days after starting antiviral treatment, at 12 hours from the last dose intake in patients on dabigatran and apixaban, and at 24 hours in those on rivaroxaban and edoxaban. […] Of the 1039 patients hospitalized between February 22 and March 15, 2020 with COVID-19 pneumonia and candidates for antiviral therapy, 32 were on treatment with a DOAC. 2020-05-06
Fibrinolytic abnormalities in acute respiratory distress syndrome (ARDS) and versatility of thrombolytic drugs to treat COVID-19. Prophylaxis treatment of COVID-19 patients with low molecular weight heparin (LMWH) is important to limit coagulopathy. […] In this review, we discuss the repurposing of fibrinolytic drugs, namely tissue-type plasminogen activator (tPA), to treat COVID-19 associated ARDS. tPA is an approved intravenous thrombolytic treatment, and the nebulizer form has been shown to be effective in plastic bronchitis and is currently in Phase II clinical trial. 2020-04-24
[An analysis of global research on SARS-CoV-2]. All articles were categorized into epidemiology, clinical diagnosis and treatment, basic research, pregnant women and children, mental health, epidemic prevention & control, and others. 2020-04-27
[Spike protein in the detection and treatment of novel coronavirus]. In this review we introduce these research works related to spike proteins, hoping it will provide reasonable ideas for the control of the current pandemic, as well as for the diagnosis and treatment of COVID-19. 2020-04-27
Pharmacy’s Call for Authorities to Aggressively Enforce Laws Addressing Price Gouging. Early reports of potential treatment for coronavirus disease (COVID-19) have raised concerns related to pharmaceutical distribution. 2020-04-24
Andrographolide as a potential inhibitor of SARS-CoV-2 main protease: an in silico approach. The lack of availability of approved treatment for this disease calls forth the scientific community to find novel compounds with the ability to treat it. 2020-05-14
Current pharmacological treatments for COVID-19: What’s next? No specific therapies/vaccines are yet available for the treatment of COVID-19. 2020-05-16
Coronavirus disease 2019 and prevalence of chronic liver disease: A meta-analysis. Further studies are needed to better investigate the causes of liver injury in patients with COVID-19 disease and the effect of treatment for COVID-19 on the liver. 2020-05-31
Role of Telehealth in the Management of COVID-19: Lessons Learned from Previous SARS, MERS, and Ebola Outbreaks. Concerns about the prevention and management of COVID-19 are on the rise, as it is crucial in contagious epidemics that travel and transfer of the patients be minimal for diagnosis, treatment, and follow-ups. 2020-04-24
SARS-CoV-2 causing pneumonia-associated respiratory disorder (COVID-19): diagnostic and proposed therapeutic options. Additionally, we have discussed various therapeutic strategies for COVID-19 under different categories, like the possible treatment plans with drug (antiviral drugs and anti-cytokines) therapy for disease prevention. […] Collectively, the review provides an overview of the SARS-CoV-2 infection outbreak along with the recent advancements and strategies for diagnosis and therapy of COVID-19. 2020-04-30
An alternative approach to minimize the risk of coronavirus (Covid-19) and similar infections. However, the current treatment options include hydroxychloroquine, tocilizumab, remdesivir, lopinavir-ritonavir (Kaletra®), and nitazoxanide. 2020-04-30
Eculizumab treatment in patients with COVID-19: preliminary results from real life ASL Napoli 2 Nord experience. In this case series, we aimed to report preliminary data obtained with anti-complement C5 therapy with eculizumab in COVID-19 patients admitted to intensive care unit (ICU) of ASL Napoli 2 Nord. […] Patients were also treated with anticoagulant therapy with Enoxaparin 4000 IU/day via subcutaneous injection, antiviral therapy with Lopinavir 800 mg/day + Ritonavir 200 mg/day, hydroxychloroquine 400 mg/day, ceftriaxone 2 g/day IV, vitamine C 6 g/day for 4 days, and were on Non-Invasive Ventilation (NIV). […] All patients successfully recovered after treatment with eculizumab. […] Eculizumab has the potential to be a key player in treatment of severe cases of COVID-19. […] Our results support eculizumab use as an off-label treatment of COVID-19, pending confirmation from the ongoing SOLID-C19 trial. 2020-04-29
The care of patients with Duchenne, Becker, and other muscular dystrophies in the COVID-19 pandemic. We highlight the importance of collaborative treatment decisions between the patient, family, and health-care provider, considering any geographic or institution-specific policies and precautions for COVID-19. 2020-05-05
Spinal muscular atrophy care in the COVID-19 pandemic era. We emphasize the importance of collaborative treatment decisions between the patient, family, and healthcare provider, considering any geographic- or institution-specific policies and precautions for COVID-19. 2020-05-06
Potential impact of the COVID-19 pandemic on financial toxicity in cancer survivors. In the context of COVID-19, cancer survivors represent a particularly vulnerable population that may be “doubly hit” by both costs of cancer treatment and financial strain imposed by the pandemic. 2020-05-29
Handling of allergen immunotherapy in the COVID-19 pandemic: An ARIA-EAACI statement. Allergen-specific immunotherapy (AIT) is one of the most important treatment options for IgE-mediated allergies and is based on immunological effects on the diseased patient. 2020-04-24
Should we wait or not? The preferable option for patients with stage IV oral cancer in COVID-19 pandemic. Patients with oral cancer are susceptible often immunosuppressed due to the disease and/or the treatment received. […] Stage IV patients with oral cancer who did not receive treatment had progression of disease and an increased mortality rate compared to patients who receive treatment but did not contract COVID-19. […] The patients who received treatment and got affected with COVID-19 had a far worse impact and higher mortality rate than all other groups. […] Isolation and deferring treatment for stage IV patients with oral cancer, so as to avoid hospital visits and contraction of COVID-19, is an advisable strategy based on this model. 2020-05-29
Transition to a virtual multidisciplinary tumor board during the COVID-19 pandemic: University of Pittsburgh experience. Multidisciplinary conferences (MDC) are an important component of head and neck oncologic care including diagnosis, treatment, and survivorship. 2020-05-29
COVID-19 Lung Injury and High Altitude Pulmonary Edema: A False Equation with Dangerous Implications. While of high utility in the management of HAPE and acute mountain sickness, systemically delivered pulmonary vasodilators and acetazolamide should not be used in the treatment of COVID-19, as they carry the risk of multiple adverse consequences including worsened ventilation-perfusion matching, impaired carbon dioxide transport, systemic hypotension and increased work of breathing. 2020-04-24
Leveraging open hardware to alleviate the burden of COVID-19 on global health systems. With the current rapid spread of COVID-19, global health systems are increasingly overburdened by the sheer number of people that need diagnosis, isolation and treatment. […] Here, we summarise community-driven approaches based on Free and Open Source scientific and medical Hardware (FOSH) as well as personal protective equipment (PPE) currently being developed and deployed to support the global response for COVID-19 prevention, patient treatment and diagnostics. 2020-04-29
Machine learning using intrinsic genomic signatures for rapid classification of novel pathogens: COVID-19 case study. Such major viral outbreaks demand early elucidation of taxonomic classification and origin of the virus genomic sequence, for strategic planning, containment, and treatment. 2020-04-29
Effect of High vs Low Doses of Chloroquine Diphosphate as Adjunctive Therapy for Patients Hospitalized With Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infection: A Randomized Clinical Trial. There is no specific antiviral therapy recommended for coronavirus disease 2019 (COVID-19). […] Data presented here refer primarily to safety and lethality outcomes during treatment on day 13. 2020-04-29
Protecting vulnerable patients with inherited anaemias from unnecessary death during the COVID-19 pandemic. With the developing COVID-19 pandemic, patients with inherited anaemias require specific advice regarding isolation and changes to usual treatment schedules. […] Cascading of accurate information for clinicians and patients is paramount to preventing adverse outcomes, such as patients who are at increased risk of fulminant bacterial infection due to their condition or its treatment erroneously self-isolating if their fever is mistakenly attributed to a viral cause, delaying potentially life-saving antibiotic therapy. 2020-05-19
Persistent viral RNA positivity during recovery period of a patient with SARS-CoV-2 infection. This patient had recovered from the pneumonia after treatment. 2020-04-24
Characteristics of patients with coronavirus disease (COVID-19) confirmed using an IgM-IgG antibody test. A combination of nucleic acid and IgM-IgG testing is a more sensitive and accurate approach for diagnosis and early treatment of COVID-19. 2020-05-08
Asymptomatic COVID-19 infection in late pregnancy indicated no vertical transmission. The puerpera returned to normal after the operation and two times of throat swab COVID-19 nucleic acid test were all negative after antiviral therapy. 2020-04-30
COVID-19 coronavirus research has overall low methodological quality thus far: case in point for chloroquine/hydroxychloroquine. Presently, no approved treatment or prophylaxis is available for COVID-19. 2020-05-08
Clinical presentation and initial management critically ill patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in Brescia, Italy. Bedside clinicians abstracted daily patient data on history, treatment, and short-term course. […] We describe management and a proposed severity scale for treatment used in this hospital. 44 patients were enrolled; with incomplete information on 11. […] Patients also received lopinivir/ritonavir (82%), hydroxychloroquine (79%), and tocilizumab (12%) according to this treatment algorithm. 2020-05-19
Head and neck oncology during the COVID-19 pandemic: Reconsidering traditional treatment paradigms in light of new surgical and other multilevel risks. The COVID-19 pandemic demands reassessment of head and neck oncology treatment paradigms. […] Additionally, novel, COVID-19-specific multilevel risks to HNC patients, HCWs and institutions, and society include: use of immunosuppressive therapy, nosocomial COVID-19 transmission, institutional COVID-19 outbreaks, and, at some locations, societal resource deficiencies requiring health care rationing. […] Until these risks are managed, we temporarily favor nonsurgical therapy over surgery for most mucosal squamous cell carcinomas, wherein surgery and nonsurgical therapy are both first-line options. 2020-05-20
Successful Treatment of Preterm Labor in Association with Acute COVID-19 Infection. This case report describes successful treatment of preterm labor during acute COVID-19 infection. […] Standard treatment for preterm labor may allow patients with acute COVID-19 infection to recover without the need for preterm delivery. […] · Standard treatment for preterm labor such as intravenous magnesium sulfate, antepartum steroid therapy and antibiotic prophylaxis for group B streptococcus infection were effective in this patient.. 2020-04-24
Helmet CPAP to Treat Acute Hypoxemic Respiratory Failure in Patients with COVID-19: A Management Strategy Proposal. Here, we discuss the rationale and some important considerations about timing, criteria, and monitoring requirements for patients with COVID-19 respiratory failure requiring a CPAP treatment. 2020-05-23
Origin, Potential Therapeutic Targets and Treatment for Coronavirus Disease (COVID-19). In this context, the present review article provides a cumulative account of the recent information regarding the viral characteristics, potential therapeutic targets, treatment options, and prospective research questions. 2020-05-29
Sex-Specific SARS-CoV-2 Mortality: Among Hormone-Modulated ACE2 Expression, Risk of Venous Thromboembolism and Hypovitaminosis D. In addition to this first aspect, the recent evidence of an increased frequency of venous thromboembolism in patients with COVID-19 (a clinical element associated with a worse prognosis) calls the attention on the safety of treatment with testosterone, in particular in hypogonadal men with greater genetic predisposition. 2020-04-28
18F-FDG PET/CT and Serial Chest CT Findings in a COVID-19 Patient With Dynamic Clinical Characteristics in Different Period. We illustrate the symptoms initiation, the laboratory test results, the imaging examination, and the treatment strategy in the duration of COVID-19 with a timeline chart. 2020-05-06
Neutralization of SARS-CoV-2 spike pseudotyped virus by recombinant ACE2-Ig. As these fusion proteins exhibit cross-reactivity against coronaviruses, they have potential applications in the diagnosis, prophylaxis, and treatment of SARS-CoV-2. 2020-04-28
Social and behavioral health responses to COVID-19: lessons learned from four decades of an HIV pandemic. We focus on multiple levels of intervention including intrapersonal, interpersonal, community, and social factors, each of which provide a reference point for understanding and elaborating on social/behavioral lessons learned from HIV prevention and treatment research. […] The investments in HIV prevention and treatment research far outweigh any infectious disease in the history of public health, that is, until now with the emergence of COVID-19. 2020-05-26
Lymphopenia that may develop in patients treated with temozolomide and immune control check-point inhibitor may be a high risk for mortality during the COVID-19 outbreak. As we know more about the clinical and laboratory features of COVID-19, which is now accepted as a pandemic, many questions have been raised about how to manage and monitor the treatment of cancer patients. […] This article was written for a hypothetical approach in cancer patients diagnosed with COVID-19 in order to be an idea of collecting data for treatment with anti-cancer drugs that cause lymphopenia. 2020-04-28
Updated diagnosis, treatment and prevention of COVID-19 in children: experts’ consensus statement (condensed version of the second edition). In the early February, 2020, we called up an experts’ committee with more than 30 Chinese experts from 11 national medical academic organizations to formulate the first edition of consensus statement on diagnosis, treatment and prevention of coronavirus disease 2019 (COVID-19) in children, which has been published in this journal. […] With accumulated experiences in the diagnosis and treatment of COVID-19 in children, we have updated the consensus statement and released the second edition recently. […] The current version in English is a condensed version of the second edition of consensus statement on diagnosis, treatment and prevention of COVID-19 in children. […] This version of experts consensus will be valuable for better prevention, diagnosis and treatment of COVID-19 in children worldwide. 2020-05-01
Recommendations for prioritization, treatment, and triage of breast cancer patients during the COVID-19 pandemic. the COVID-19 pandemic breast cancer consortium. As hospital resources and staff become more limited during the COVID-19 pandemic, it becomes critically important to define which BC patients require more urgent care and which patients can wait for treatment until the pandemic is over. […] Additionally, we provide treatment recommendations for each of these patient scenarios. […] Priority A patients have conditions that are immediately life threatening or symptomatic requiring urgent treatment. […] Priority B patients have conditions that do not require immediate treatment but should start treatment before the pandemic is over. […] Physicians should use these recommendations to prioritize care for their BC patients and adapt treatment recommendations to the local context at their hospital. 2020-05-18
Racial Variations in COVID-19 Deaths May Be Due to Androgen Receptor Genetic Variants Associated with Prostate Cancer and Androgenetic Alopecia. Are Anti-Androgens a Potential Treatment for COVID-19? Nevertheless, genetic factors in different ethnic groups often contribute to disease severity and treatment response. […] Finally, if a link to genetic variations in the androgen receptor and COVID-19 disease severity can be established, it would suggest new treatment options. 2020-04-25
Recommendations for Deep Brain Stimulation Device Management During a Pandemic. Movement disorder (Parkinson’s disease, essential tremor, dystonia), neuropsychiatric disorder (obsessive compulsive disorder, Tourette syndrome, depression), and epilepsy patients can develop varying degrees of symptom worsening from interruption of therapy due to neurostimulator battery reaching end of life, device malfunction or infection. […] Similarly, patients with generalized dystonia can develop status dystonicus, patients with obsessive compulsive disorder can become suicidal, and epilepsy patients can experience potentially life-threatening worsening of seizures as a result of therapy cessation. […] The decision for replacement of the implantable pulse generator to prevent interruption of DBS therapy should be made on a case-by-case basis taking into consideration battery status and a patient’s tolerance to potential therapy disruption. 2020-04-25
Expression of SARS-CoV-2 Entry Molecules ACE2 and TMPRSS2 in the Gut of Patients With IBD. We further hypothesized that their expression could be affected by inflammation or medication usage. […] Patients with IBD do not have higher expression during inflammation; medical therapy is associated with lower levels of ACE2. 2020-05-14
Expert recommendations for the management of autoimmune bullous diseases during the COVID-19 pandemic. Corticosteroids and non-steroid immunomodulatory agents are the mainstays of treatment. […] Treatment can be challenging particularly in pemphigus, mucous membrane pemphigoid, and epidermolysis bullosa acquisita which may require more intense immunosuppressive approaches. 2020-04-25
Practical Considerations for the Diagnosis and Treatment of Fibrotic Interstitial Lung Disease During the COVID-19 Pandemic. Major issues for patients with ILD will include restricted access to key components of the diagnostic process, new uncertainties in the use of common ILD pharmacotherapies, limited ability to monitor both disease severity and the presence of medication adverse effects, and significantly curtailed research activities. 2020-05-10
Current status of potential therapeutic candidates for the COVID-19 crisis. There is currently no specific treatment available for patients with COVID-19 infection. […] Numerous potential therapies, including supportive intervention, immunomodulatory agents, antiviral therapy, and convalescent plasma transfusion, have been tentatively applied in clinical settings. 2020-04-29
Impact of weather on COVID-19 pandemic in Turkey. The present day is dominated by studies on determining the factors that affect, taking preventive actions, and trying to find an effective treatment on top priority. 2020-05-19
Overview of Covid-19; its prevention and management in the light of Unani medicine. Unani is a traditional system of medicine developed during the middle ages, which employs natural drugs of herbal, animal and mineral origin for treatment. 2020-05-19
How to improve adherence with quarantine: rapid review of the evidence. To improve this, public health officials should provide a timely, clear rationale for quarantine and information about protocols; emphasise social norms to encourage this altruistic behaviour; increase the perceived benefit that engaging in quarantine will have on public health; and ensure that sufficient supplies of food, medication and other essentials are provided. 2020-05-29
The Mechanistic Target of Rapamycin (mTOR): Novel Considerations as an Antiviral Treatment To date, no definitive treatment orvaccine application exists for COVID-19. […] Although new investigations seek to repurpose existingantiviral treatments for COVID-19, innovative treatment strategies not normally considered tohave antiviral capabilities may be critical to address this global concern. […] One such avenue that mayprove to be exceedingly fruitful and offer exciting potential as new antiviral therapy involves themechanistic target of rapamycin (mTOR) and its associated pathways of mTOR Complex 1(mTORC1), mTOR Complex 2 (mTORC2), and AMP activated protein kinase (AMPK). […] Yet, important considerationsfor the development of safe and effective antiviral therapy with mTOR pathways exist. 2020-05-04
Headache medication and the COVID-19 pandemic. We here discuss this concern in relation to headache treatment and conclude that, based on current evidence, there is no reason to abandon treatment of headache patients with RAS inhibitors or ibuprofen. 2020-04-28
Surgery during the COVID-19 pandemic: A comprehensive overview and perioperative care. As the global incidence of COVID-19 disease is increasing dramatically, health systems worldwide started to suffer in terms of its capability to manage affected people and the ability to provide standard treatment for critically ill patients in a safe environment. 2020-04-29
[Management of a radiotherapy center during the COVID-19 outbreak: The experience of the Mulhouse hospital centre (France)]. In the radiotherapy department of Mulhouse hospital (France), we pointed five points out: protection of medical and paramedical staff, protection of patients undergoing treatment, detection of patients suspected of being infected by SARS-CoV-2 and their management, reorganization of the patient circuit and measures regarding the quality management. 2020-04-28
SARS-CoV-2 and DPP4 inhibition: Is it time to pray for Janus Bifrons? It has been hypothesized that DPP4 inhibition, a therapy currently available for type 2 diabetes, might represent a target for decreasing the risk of the acute respiratory complications of the COVID-19 infection but (1) lack of demonstration of SARS-CoV2 binding to DPP4 (2) possible protective role of sDPP4 in Middle East respiratory Syndrome (MERS-CoV) (3) demonstrated inhibition and downregulation of DPP4 by HIV1 and MERS-CoV and (4) not exclusive role of the receptor binding in tropism of the Coronavirus family, support that DPP4 inhibition at present doesn’t represent a plausible approach to mitigate COVID-19. 2020-05-11
Pharmacological perspective: glycyrrhizin may be an efficacious therapeutic agent for COVID-19. This brief article discusses the therapeutic potential of glycyrrhizin for the treatment of COVID-19 from the perspective of its pharmacological action, including binding angiotensin-converting enzyme II (ACE2), downregulating proinflammatory cytokines, inhibiting the accumulation of intracellular reactive oxygen species (ROS), inhibiting thrombin, inhibiting the hyperproduction of airway exudates, and inducing endogenous interferon. 2020-05-03
Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2): An overview of viral structure and host response. We further explain the therapeutic approaches that can be taken in the treatment and prevention of this viral infection. 2020-05-27
Factors associated with negative conversion of viral RNA in patients hospitalized with COVID-19. These predictors would provide a new perspective on early identification of patients with prolonged viral shedding and facilitate optimal isolation protocols and treatment strategies. 2020-05-19
Imaging of coronavirus disease 2019: A Chinese expert consensus statement. Early detection, isolation, diagnosis, and treatment are the most effective means of prevention and control. […] The current gold standard for the diagnosis of COVID-19 is the detection of coronavirus nucleic acids, but imaging has an important role in the detection of lung lesions, stratification, evaluation of treatment strategies, and differentiation of mixed infections. 2020-05-15
Update on treatment of COVID-19: ongoing studies between promising and disappointing results. Through PubMed, we explored the relevant articles published on treatment of COVID-19 and on trials ongoing up to April 15, 2020. 2020-04-28
The Coronavirus Pandemic: What Does the Evidence Show? There is no proven antiviral agent against SARS-CoV-2 so the treatment for COVID-19 is symptomatic, aiming for the management of the symptoms and prevention of the complications. […] Numerous antiviral compounds used to treat other infections are being clinically researched to find possible treatment. 2020-04-28
The impact of respiratory protective equipment on difficult airway management: a randomised, crossover, simulation study. Treatment times and wearer comfort were determined and compared. […] All anaesthetists accomplished the treatment objectives of all study arms without adverse events. 2020-05-29
What should a cardiologist know about coronavirus disease 2019? Early recognition and treatment is crucial in these cases. […] Thus, it is important to know typical COVID‑19 symptoms, possible clinical manifestations, complications, and recommended treatment. 2020-04-30
Urologic Surgery and COVID-19: How the Pandemic Is Changing the Way We Operate. Recommendations should be adapted to the local environment and will continue to evolve as more data become available, the shortage of testing and PPE is resolved, and a vaccine and therapeutics for COVID-19 are developed. 2020-05-25
COVID-19: an update on diagnostic and therapeutic approaches. This pandemic situation has forced scientists to rework strategies to combat infectious diseases through drugs, treatment, and control measures. […] COVID-19 treatment requires both limiting viral multiplication and neutralizing tissue damage induced by an inappropriate immune reaction. […] Currently, various diagnostic kits to test for COVID-19 are available, and repurposing therapeutics for COVID-19 has shown to be clinically effective. […] As the global demand for diagnostics and therapeutics continues to rise, it is essential to rapidly develop various algorithms to successfully identify and contain the virus. 2020-04-29
Clinical Consensus Recommendations Regarding Non-Invasive Respiratory Support in the Adult Patient with Acute Respiratory Failure Secondary to SARS-CoV-2 infection. The document provides clinical recommendations for the noninvasive respiratory support (noninvasive ventilation, high flow oxygen therapy with nasal cannula) in any patient with suspected or confirmed presentation of COVID-19 with acute respiratory failure. 2020-04-27
SEPAR-AEER Consensus Recommendations on the Usefulness of the Thoracic Ultrasound in the Management of the Patient with Suspected or Confirmed Infection with COVID-19. These findings will facilitate the decision making regarding the patient management, both when deciding the place of admission of the patient and the type of treatment to be prescribed. 2020-04-29
Pharmacotherapy in COVID-19; A narrative review for emergency providers. The COVID-19 pandemic has been particularly challenging due to a lack of established therapies and treatment guidelines. […] Several antivirals, antimalarials, and biologics are being considered for treatment at this time. […] The purpose of this literature review is to synthesize the available information regarding treatment options for COVID-19 and serve as a resource for health care professionals. […] This narrative review was conducted to summarize the effectiveness of current therapy options for COVID-19 and address the controversial use of non-steroidal anti-inflammatory drugs (NSAIDs), angiotensin converting enzyme (ACE) inhibitors, and angiotensin receptor blockers (ARBs). […] PubMed and SCOPUS were queried using a combination of the keywords “COVID 19,” “SARS-CoV-2,” and “treatment.” All types of studies were evaluated including systematic reviews, case-studies, and clinical guidelines. […] Current guidelines recommend combination treatment with hydroxychloroquine/azithromycin or chloroquine, if hydroxychloroquine is unavailable, in patients with moderate disease, although these recommendations are based on limited evidence. […] Until the results of these trials become available, we must use the best available evidence for the prevention and treatment of COVID-19. 2020-05-03
COVID-19 outbreak: An elusive enemy. Since containment of the outbreak may have partially failed due to asymptomatic transmission, it is imperative to accelerate the development of rapid point-of-care diagnostic tests, vaccines, and therapeutics for the COVID-19 epidemic. 2020-04-30
Pharmacy administration and pharmaceutical care practice in a module hospital during the COVID-19 epidemic. Pharmacists have successfully completed the tasks of purchase, storage, and free distribution of drugs worth ¥1.03 million (approximately $146,000), reviewed about 20,000 electronic orders, provided one-on-one online medication consultation for 484 patients, and held 5 lectures on rational drug use knowledge, which could help reduce irrational drug use and minimize the risk involved. […] They not only ensured the timely supply of the drugs but also reduced the incidence of drug-induced risks through medication review and guidance, thereby improving patient compliance and helping the patients rebuild their confidence in overcoming the disease. 2020-04-30
Treatment of SARS-CoV-2: How far have we reached? Currently, no treatment for SARS-CoV-2 are approved because of lack of evidence, but a number of clinical trials are in process and we are expecting fruitful results very soon. […] This review focuses on various approaches of treatment and few of the most recent clinical trials carried out in this field. 2020-05-08
Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2): Emergence, History, Basic and Clinical Aspects. This review article summarizes the developing situation surrounding the SARS-CoV-2 pandemic with respect to its epidemiology, unique genomic structure, possible origins, transmission, pathogenesis, comparison with other deadly species of Coronaviruses (CoV) and emerging treatment strategies built on informed literature. 2020-05-22
SARS-CoV-2 (COVID-19) and intravascular volume management strategies in the critically ill. Due to lack of data on treatment strategies specific to this subset of patients, currently available evidence on management of the critically ill needs to be extrapolated and customized to their clinical needs. 2020-05-06
Brief Review on COVID-19: The 2020 Pandemic Caused by SARS-CoV-2. In this study, we will provide a brief review of viral origin, identification, symptoms, transmission, diagnosis, and potential treatment strategies for the newly identified SARS-CoV-2 strain. 2020-04-30
Searching an Effective Therapy for the Coronavirus Pandemic: Do We See Light at the End of the Tunnel? Recent findings of an open-label study that investigated the use of hydroxychloroquine and azithromycin in COVID-19 patients in Marseille, France, has garnered some optimism in scientific quarters and the general public alike in terms of finding a treatment regimen to control the rampant rise of COVID-19. […] We will discuss the potential off-label therapy and studies as it pertains to COVID-19. 2020-04-30
Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2): An Update. Since there is no specific therapeutic intervention nor a vaccine available against the virus, supportive management and treatment with non-specific therapeutic agents (repurposed drugs) may provide relief to the patients. 2020-04-30
Corona Virus Disease 2019 (COVID-19) Presenting as Acute ST Elevation Myocardial Infarction. We need more research in Covid-19 patients with cardiovascular involvement for early diagnosis, prevention of exposure to health care workers and effective treatment. 2020-04-30
COVID-19 Tragic Pandemic: Concerns over Unintentional “Directed Accelerated Evolution” of Novel Coronavirus (SARS-CoV-2) and Introducing a Modified Treatment Method for ARDS. Here, we introduce a modified treatment method for COVID-19-associated pneumonia. 2020-04-30
Atypical presentation of SARS-CoV-2 infection: A case report. Careful acquisition of an epidemiological history is necessary to make a correct diagnosis and strategize a treatment plan. 2020-04-30
Coronaviruses: A patent dataset report for research and development (R&D) analysis. This work shows a patent database for Coronaviruses that provides an overview of the patenting activity and trends in focused antiviral therapy with the use of triazole based compounds, glycoprotein, and protease inhibitors as possible treatment. […] The patent data was obtained from Orbit Intelligence Software using a patent family structure to get a big database that could be used for built patent landscape report (PLR), market analysis, technical and competitive intelligence, and monitoring and survey of a new ideas for the treatment of coronavirus diseases. 2020-04-30
Practice considerations for proton beam radiotherapy of uveal melanoma during the COVID-19 pandemic: PTCOG Ocular experience. In light of the COVID-19 pandemic, hospitals and proton eye therapy facilities must analyze several factors to ensure appropriate treatment protocols for patients and provider teams. […] Practice considerations to limit COVID-19 transmission in the proton ocular treatment setting for UM are necessary. […] The Particle Therapy Co-Operative Group (PTCOG) is the largest international community of particle/proton therapy providers. 2020-04-30
Rational Use of Tocilizumab in the Treatment of Novel Coronavirus Pneumonia. Tocilizumab, which is the IL-6 receptor antagonist, has been approved by the US FDA for the treatment of cytokine release syndrome (CRS), is expected to treat cytokine storm caused by COVID-19 and is now in clinical trials. […] In this paper, we will elaborate the role of cytokine storm in COVID-19, the mechanism of tocilizumab on cytokine storm and the key points of pharmaceutical care based on the actual clinical application for COVID-19 in our hospital, the latest research reports, clinical trial progress of tocilizumab, drug instruction from the US FDA, and “Diagnosis and Treatment Plan of Novel Coronavirus Pneumonia (seventh trial edition)” in China, so as to provide reference for the treatment of COVID-19. 2020-05-28
Noscapine, a possible drug candidate for attenuation of cytokine release associated with SARS-CoV-2. Successful treatment of viral infections has proven to be huge challenge for modern medicine with the most effective approach being prior vaccination. […] Therefore, any treatment which can decrease the severe symptoms due to lung damage may help attenuate mortality rates. […] Noscapine, a medication used for the treatment of cough, has been shown to inhibit bradykinin enhanced cough response in man. 2020-04-27
Severe COVID-19 in a renal transplant recipient: A focus on pharmacokinetics. The clinical course was complicated by extreme overexposure to the mammalian target of rapamycin inhibitor everolimus, following coadministration of chloroquine and lopinavir/ritonavir therapy. […] The case is illustrative for dilemmas that transplant professionals may face in the absence of evidence-based COVID-19 therapy and concurrent pressure for exploration of experimental pharmacological treatment options. […] However, the risk-benefit balance of experimental or off-label therapy may be weighed differently in organ transplant recipients than in otherwise healthy COVID-19 patients, owing to their immunocompromised status and potential drug interactions with immunosuppressive therapy. […] With this case report, we aimed to achieve increased awareness and improved management of drug-drug interactions associated with the various treatment options for COVID-19 in renal transplant patients. 2020-05-13
Rheumotologitsts’ view on the use of hydroxychloroquine to treat COVID-19. Anti-malarial medicine chloroquine (CQ) and particularly its chemical analogue hydroxychloroquine (HCQ) have been recommended as promising candidate therapeutics that are now under either compassionate off-label use or clinical trials for the treatment of COVID-19 patients. […] Given the fact that for decades HCQ has been approved as an immunomodulatory drug for the long term treatment of chronic rheumatic diseases, as experienced rheumatologists, we would like to share our thoughts in this regard and trigger a brainstorm among clinical care providers for exchanging their diverse opinions on this urgent topic. 2020-05-05
SARS-CoV-2 RNA dependent RNA polymerase (RdRp) targeting: an in silico perspective. New treatment against SARS-CoV-2 now is a must. […] The compounds 2 and 3 may tightly bind to the SARS-CoV-2 RdRp and so may be successful in the treatment of COVID-19. 2020-05-16
Focus on Receptors for Coronaviruses with Special Reference to Angiotensin-converting Enzyme 2 as a Potential Drug Target - A Perspective. In this framework, Gurwitz [40] proposed to use AT1R blockers, such as losartan, as a potential treatment of COVID-19 infection. […] In fact, losartan as well as olmesartan, used for treating hypertension in patients, were able to increase ACE2 expression after 28 days treatment of rats with myocardial infarction [41]. […] Then, Gurwitz suggests to evaluate severity of symptoms in COVID-19 infected patients under previous chronic treatment with AT1R blockers in comparison to COVID-19 infected patients who did not take AT1R blockers [40]. 2020-04-27
The After Diagnosis Head and Neck cancer-specific Patient Concerns Inventory (HaNC-AD) as a pre-treatment preparation aid during the COVID-19 pandemic. At present, HNC patients may be anxious and due to logistical issues, may not be adequately prepared for their treatment. […] To ensure that patients have a thorough understanding of their treatment and expected outcome during the current COVID-19 crisis there may be merit in the use of the HaNC-AD PCI. 2020-05-08
Infectious Diseases Society of America Guidelines on the Treatment and Management of Patients with COVID-19. There are many pharmacologic therapies that are being used or considered for treatment of COVID-19. […] Develop evidence-based rapid guidelines intended to support patients, clinicians and other health-care professionals in their decisions about treatment and management of patients with COVID-19. […] The IDSA guideline panel agreed on 7 treatment recommendations and provided narrative summaries of other treatments undergoing evaluations. 2020-05-06
Major head and neck reconstruction during the COVID-19 pandemic: The University of Pittsburgh approach. The 2019 novel coronavirus (COVID-19) pandemic has created significant challenges to the delivery of care for patients with advanced head and neck cancer requiring multimodality therapy. 2020-05-29
Navigating the impact of COVID-19 on palliative care for head and neck cancer. In a palliative care clinic, this apprehension gets exemplified, as these patients have limited life expectancy. 2020-05-29
Why Fibrinolytic Therapy for STEMI in The COVID-19 Pandemic is Not Your New Best Friend. As directors of two major academic cardiac catheterization laboratories in the city, we both have had to operationalize logistical planning of physician and staff redeployments as well as modification of our respective hospital units including conversion of large portions of the catheterization laboratory into COVID-19 intensive care units in order to deal with the surge of COVID-19 patients within the hospital. 2020-04-27
A Quantitative Framework for Modeling COVID-19 Risk During Adjuvant Therapy Using Published Randomized Trials of Glioblastoma in the Elderly. During the ongoing COVID-19 pandemic, contact with the healthcare system for cancer treatment can increase risk of infection and associated mortality. […] Treatment recommendations must consider this risk for elderly and vulnerable cancer patients. […] We extracted individual patient-level data (IPLD) for 1,321 patients from Kaplan-Meier curves from five randomized trials on treatment of elderly GBM patients including available subanalyses based on MGMT methylation status. […] Our simulations reveal how COVID-19-associated risks affect survival under different treatment regimens. […] In patients with methylated MGMT receiving single modality treatment, TMZ-alone treatment approaches may be an option in settings with high COVID-19-associated risk. […] Our quantitative framework can serve as a model for assessing COVID-19 risk associated with treatment across neuro-oncology. 2020-05-06
Effect of High vs Low Doses of Chloroquine Diphosphate as Adjunctive Therapy for Patients Hospitalized With Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infection: A Randomized Clinical Trial. There is no specific antiviral therapy recommended for coronavirus disease 2019 (COVID-19). […] Data presented here refer primarily to safety and lethality outcomes during treatment on day 13. 2020-04-30
A potential ex vivo infection model of human induced pluripotent stem cell-3D organoids beyond coronavirus disease 2019. This approach will provide much needed insight into the underlying molecular dynamics of COVID-19 for the development of novel treatment and prevention strategies. 2020-04-27
Patient blood management during the COVID-19 pandemic: a narrative review. We discuss how preventative and control measures implemented during the COVID-19 crisis could affect the prevalence of anaemia, and highlight issues regarding the diagnosis and treatment of anaemia in patients requiring elective or emergency surgery. 2020-05-06
Managing COVID-19 in Renal Transplant Recipients: A Review of Recent Literature and Case Supporting Corticosteroid-sparing Immunosuppression. Treatment for other viral infections in renal transplant recipients often includes a reduction in immunosuppression; however, no current guidelines are available recommending the optimal approach to managing immunosuppression in the patients who are infected with SARS-CoV-2. […] It is currently advised to avoid corticosteroids in the treatment of SARS-CoV-2 outside of critically ill patients. […] Recently published cases describing inpatient care of COVID-19 in renal transplant recipients differ widely in disease severity, time from transplantation, baseline immunosuppressive therapy, and the modifications made to immunosuppression during COVID-19 treatment. 2020-05-26
Changes in emergency service access after spread of COVID19 across Italy. At the time of writing, our Government has passed emergency laws (March 11, 2020), with a view to preventing widespread viral infection among the population, which may well lead to an increase in the number of people requiring intensive care unit (ICU) hospital treatment. 2020-04-27
Vaginal delivery in SARS-CoV-2-infected pregnant women in Northern Italy: a retrospective analysis. Data were collected from the clinical records using a standardised questionnaire on maternal general characteristics, any medical or obstetric co-morbidity, course of pregnancy, clinical signs and symptoms, treatment of COVID 19 infection, mode of delivery, neonatal data and breastfeeding. 2020-05-29
Measuring weight with e-scales in clinical and research settings during the COVID-19 pandemic. With the COVID-19 pandemic, clinicians and researchers have been suddenly confronted with the difficulty of treatment provision and continuation of clinical trials without face-to-face contact. 2020-04-27
Coronavirus Disease 2019 in a Hemodialysis Patient. The difficulties in diagnosis, infection control, and treatment of COVID-19 in maintenance HD patients are discussed in this report. 2020-04-27
[The SARS-CoV-2 Pandemic and an Attempted Suicide of a Patient with Delusional Disorder]. Building a therapeutic relationship and integrating her into an outpatient clinic was possible despite her lack of insight into the illness and her rejection of medical treatment. 2020-04-29
[Discussion on early warning, prevention and control of emerging infectious diseases from a macroscopic perspective based on big data and effective distance model: enlightenment of COVID-19 epidemic data in China]. Objective: To provide a system for warning, preventing and controlling emerging infectious diseases from a macroscopic perspective, using the COVID-19 epidemic data and effective distance model. Methods: The dates of hospitalization/isolation treatment of the first confirmed cases of COVID-19 and the cumulative numbers of confirmed cases in different provinces in China reported as of 23 February, 2020 were collected. 2020-04-28
[Epidemic characteristics and trend analysis of the COVID-19 in Hubei province]. Objective: By describing and analyzing the epidemic characteristics and trends of the attack rate, the crude mortality and relevant indexes in Hubei province during the pandemic of COVID-19 to provide comprehensive evaluations of the epidemic trends and the effects of intervention measures. Methods: Based on the case data reported in Hubei province during the COVID-19 epidemic, combined with the important time of major interventions and event, the cumulative attack rate, the sequential increase rate of new cases, baseline increase rate of new cases, the observation- confirmed case conversion rate, the cumulative crude mortality, the daily severe case rate, and the ratio of death to severe were used to describe and analyze the epidemic characteristics in different phases of the COVID-19 epidemic. Results: The epidemic experienced an outbreak phase from January 10 to February 3 with large amount of case reported, a peak phase from February 4 to February 19 with continuous increasing number of new cases and deaths, a platform phase from February 20 to March 3 with balanced diagnosis and treatment number, and a descending phase from March 4 to March 18 with decreased diagnosis and increased treatment number. 2020-04-28
[Suggestions on reforming and improving the prevention and treatment system for major epidemic diseases in China]. Based on systematic review of the role of clinical treatment, disease control and scientific research, and combining with the problems exposed by the COVID-19 epidemic, suggestions were proposed to reform and improve the prevention and treatment system for major epidemics diseases in China. […] In clinical treatment, it is necessary to enhance clinical staff’s awareness of law-based reporting, capabilities of syndromic surveillance, the use of infectious diseases reporting systems, and to improve national or local monitoring platforms for emerging infectious diseases detection. […] As for scientific research in major epidemic response, it is essential to strengthen research projects guided by national requests, build research institutions that can “make a final decision”, establish national and regional key laboratories, and strengthen strategic technical reserve for emergency disease control and treatment. 2020-04-28
[Clinical outcomes of COVID-19 cases and influencing factors in Guangdong province]. In the epidemic period, classified management of COVID-19 cases should be promoted according to needs for control and prevention of isolation and treatment for the purpose of rational allocation of medical resources. 目的: 分析广东省新型冠状病毒肺炎(COVID-19)病例的临床转归及其影响因素,为优化医疗救治及疫情防控的策略提供参考依据。 2020-04-28
[Preliminary clinical study of direct renin inhibitor aliskiren in the treatment of severe COVID-19 patients with hypertension]. Objective: To explore the feasibility of direct renin inhibitor aliskiren for the treatment of severe patients of COVID-19 with hypertension. Methods: A retrospective case analysis of effectiveness and safety of aliskiren treatment to lower blood pressure in three severe and one critically ill patients of COVID-19 with hypertension. Results: Four patients, two males and two females, with an average age of 78 years (66-87 years), were referred to hospital mainly because of respiratory symptoms. […] On the basis of comprehensive therapy combined with antiviral and oxygenation treatment, aliskiren antihypertensive treatment was taken for three to four weeks. […] The condition improved, and all patients had reached the discharge standard and were discharged. Conclusion: Our preliminary clinical data shows that aliskiren’s antihypertensive therapy is effective and safe for severe COVID-19 patients complicated with hypertension. […] Further clinical aliskiren therapy study is required with more COVID-19 patients.. 目的: 探索直接肾素抑制剂阿利吉伦用于重型新型冠状病毒肺炎(COVID-19)合并高血压患者治疗的可行性。 2020-04-28
[Comparison of epidemiological and clinical characteristics of SARS, pandemic (H1N1) 2009 and COVID-19, and consideration on prevention and control strategies of COVID-19]. Recognizing the characteristics of three diseases, especially COVID-19, and improving the disease awareness of COVID-19 will help better implement the guidelines of “scientific prevention and treatment, precise implementation” and prevent and control COVID-19. 2020-04-28
Shedding Light on the Effect of Natural Anti-Herpesvirus Alkaloids on SARS-CoV-2: A Treatment Option for COVID-19. Thus, this special focus is an attempt to hunt down various treatment options to combat COVID-19 based on repurposing drugs that are known to have multiple antiviral properties, including against herpesvirus. 2020-04-29
Putative Inhibitors of SARS-CoV-2 Main Protease from A Library of Marine Natural Products: A Virtual Screening and Molecular Modeling Study. Currently, some HIV protease inhibitors (i.e., Lopinavir) are proposed for the treatment of COVID-19, although their effectiveness has not yet been assessed. 2020-04-29
Increasing the Signal-to-Noise Ratio: COVID-19 Clinical Synopsis for Outpatient Providers. This review article aims to bridge this gap by briefly reviewing the key points of the evaluation and treatment of patients with COVID-19 in the ambulatory clinic environment. 2020-04-30
Laryngeal Evaluation during the COVID-19 Pandemic: Transcervical Laryngeal Ultrasonography. When possible, alternative diagnostic and treatment strategies should be pursued. 2020-04-28
Evidence-Based Guidelines for Management of Head and Neck Mucosal Malignancies during the COVID-19 Pandemic. The purpose of this review is to evaluate the current evidence surrounding the treatment of these patients during this pandemic and to provide evidence-based recommendations with attention to increased risk in this setting. […] Patients with head and neck mucosal malignancy require continued treatment despite the current pandemic state. […] Care must be taken at all stages of treatment to minimize the risk to patients and health care workers while maintaining focus on minimizing use of limited resources. 2020-04-28
Best Practice Recommendations for Pediatric Otolaryngology during the COVID-19 Pandemic. Although the full repercussions of this disease have yet to be realized, the outlined recommendations will guide otolaryngologists in the treatment of pediatric patients in the face of an unprecedented global health crisis. 2020-04-28
On the Pharmacy Radar: COViD-19 and Older People. Presented here is a range of information arising from related areas that have impact upon the safety and efficacy of drug therapy in the context of COVID-19. […] Issues include pharmacy practice, clinical therapeutics, and possible new treatments for the virus. 2020-04-30
Can You Catch It? Lessons Learned and Modification of ED Triage Symptom- and Travel-Screening Strategy. Although highly hazardous communicable diseases like Ebola virus disease and MERS are of concern due to their mortality rates and limited treatment options, these same concepts may be applied to the early identification and isolation of patients suspected of having more common communicable diseases like measles and influenza, emphasizing the importance of protocol-based screening in the healthcare environment. 2020-04-30
Inappropriate Antibiotic Consumption as a Possible Cause of Inflammatory Storm and Septic Shock in Patients Diagnosed with Coronavirus Disease 2019 (COVID-19). So far, no successful specific treatment has been found for this disease. […] Altogether, we highly recommend clinicians to look after those antibiotics with anti-inflammatory activity for both empiric antibiotic therapy and reducing the inflammation to prevent septic shock in patients with diagnosed COVID-19. 2020-04-30
Coronavirus disease 2019 (COVID-19): A literature review. In this literature review, the causative agent, pathogenesis and immune responses, epidemiology, diagnosis, treatment and management of the disease, control and preventions strategies are all reviewed. 2020-05-05
Nutritional status and COVID-19: an opportunity for lasting change? Despite international efforts to identify a specific treatment, therapy remains supportive and is principally focused on optimising respiratory function. 2020-04-28
Evaluation of the QIAstat-Dx Respiratory SARS-CoV-2 Panel, the first rapid multiplex PCR commercial assay for SARS-CoV-2 detection. Compatibility of sample pre-treatment for viral neutralisation or viscous samples with the QIAstat-SARS system were also tested.The QIAstat-Dx Respiratory SARS-CoV-2 Panel demonstrated a comparable sensitivity to the WHO recommended assay with a limit of detection at 1000 copies/mL. 2020-04-28
Interactions of coronaviruses with ACE2, angiotensin II, and RAS inhibitors-lessons from available evidence and insights into COVID-19. Until further data are available, it is recommended that ARB and ACEI medications be continued for the treatment of patients with cardiovascular disease and hypertension, especially those at high risk, according to guideline-directed medical therapy based on the currently available evidence. 2020-04-30
Tackling Corona Virus Disease 2019 (COVID 19) in Workplaces. Currently no vaccine is available and treatment is mainly supportive. 2020-04-30
Prediction of numbers of the accumulative confirmed patients (NACP) and the plateau phase of 2019-nCoV in China. But for Hubei Province, the subjects of Wuhan City and Hubei Province were included from the time of admission to the Huoshenshan Hospital to present day in order to ensure that all or the majority of the confirmed and suspected patients were collected for diagnosis and treatment. 2020-05-16
[Nosocomial infection with SARS-Cov-2 within Departments of Digestive Surgery]. The reasons for hospitalization were: surgical treatment of cancer (n = 5), complex emergencies (n = 5), treatment of complications linked to cancer or its treatment (n = 3), gastroplasty (n = 1), and stoma closure (n = 1). 2020-04-28
SARS-CoV-2 infection in a patient on chronic hydroxychloroquine therapy: Implications for prophylaxis. Hydroxychloroquine and chloroquine have been used as treatment and are being considered as prophylaxis. […] Our patient developed COVID-19 while on hydroxychloroquine and although more work is needed, this calls into question the role of these medications as preventive therapy. 2020-05-06
A guide for urogynecologic patient care utilizing telemedicine during the COVID-19 pandemic: review of existing evidence. We grouped FPMRS conditions into those in which virtual management differs from direct in-person visits and conditions in which treatment would emphasize behavioral and conservative counseling but not deviate from current management paradigms. 2020-05-01
[Current guidance of the German Society of Rheumatology for the care of patients with rheumatic diseases during the SARS-CoV-2/Covid 19 pandemic]. In the current SARS-CoV-2 pandemic there are many questions regarding the safe treatment of patients with inflammatory rheumatic diseases. 2020-05-08
FDG-PET/CT findings highly suspicious for COVID-19 in an Italian case series of asymptomatic patients. In view of the PET/CT findings, home isolation, symptom surveillance, and treatment (in 3/5 patients) were indicated. 2020-05-28
Clinical characteristics of 145 patients with corona virus disease 2019 (COVID-19) in Taizhou, Zhejiang, China. Of the 43 severely ill patients, 6 (14%) received high-flow nasal cannula oxygen therapy, and 1 (2.3%) received invasive mechanical ventilation. 2020-05-07
Head and neck surgical oncology in the time of a pandemic: Subsite-specific triage guidelines during the COVID-19 pandemic. The MD Anderson Head and Neck Surgery Treatment Guidelines Consortium devised the following to provide guidance on triaging head and neck cancer (HNC) surgeries based on multidisciplinary consensus. […] Options for alternative treatment modalities are provided if surgical treatment needs to be deferred. 2020-05-29
The Use of Non-invasive Vagus Nerve Stimulation to Treat Respiratory Symptoms Associated With COVID-19: A Theoretical Hypothesis and Early Clinical Experience. Both patients reported clinically meaningful benefits from nVNS therapy. 2020-05-13
Interim Guidelines on Antiviral Therapy for COVID-19. As COVID-19 has such varied clinical manifestations and case fatality rates, no standard antiviral therapy regimen has been established other than supportive therapy. 2020-04-28
Severe Thrombocytopenia in a Patient with COVID-19. Since clinical feature of COVID-19 has not been fully evaluated yet, empirical antibacterial agents are frequently combined for the treatment of COVID-19 in addition to antiviral agents, concerning co-existing bacterial pathogens. 2020-04-28
Practice recommendations for lung cancer radiotherapy during the COVID-19 pandemic: An ESTRO-ASTRO consensus statement. In that same scenario, postponement or interruption of radiotherapy treatment of COVID-19 positive patients is generally recommended to avoid exposure of cancer patients and staff to an increased risk of COVID-19 infection. […] Case-specific consensus recommendations regarding multimodality treatment strategies and fractionation of radiotherapy are provided. 2020-05-29
Radiotherapy workflow and protection procedures during the Coronavirus Disease 2019 (COVID-19) outbreak: Experience of the Hubei Cancer Hospital in Wuhan, China. Under its lead, the following measures were implemented in the radiation oncology department: the radiotherapy clinic was divided into different infection control zones with varying levels of protection; special staff and patient infection control training sessions were conducted and appropriate measures deployed; daily symptom testing criteria were implemented for patients undergoing treatment; special rotating schedules and infection control methods were implemented for various staff members such as medical physicists/dosimetrists and radiation therapists; modified radiotherapy workflow and specialized treatment area cleaning and disinfection policies and procedures were designed and executed; and special medical waste disposal methods were implemented. […] We began treating patients using this new COVID-19 radiotherapy treatment workflow and infection control measures on January 30, 2020. 2020-05-27
A rapid review of evidence and recommendations from the SIOPE radiation oncology working group to help mitigate for reduced paediatric radiotherapy capacity during the COVID-19 pandemic or other crises. We have undertaken a rapid review of published literature on the role of radiotherapy in the multimodality treatment of paediatric cancers governing the European practise of paediatric radiotherapy. […] This review provides evidence-based treatment recommendations during unexpected shortage of paediatric radiotherapy facilities. 2020-05-27
Recommendations for the use of radiation therapy in managing patients with gastrointestinal malignancies in the era of COVID-19. We performed a review of the literature, as well as national and international treatment guidelines, seeking data in support of the RADS principle (Remote visits, Avoid radiation, Defer radiation, Shorten radiation) [3] as it applies to gastrointestinal cancers. 2020-05-27
Respiratory and pulmonary complications in head and neck cancer patients: Evidence-based review for the COVID-19 era. Treatment toxicities from radiation or chemoradiation therapy significantly increase these risks. 2020-05-29
Pandemic Uncertainty: Considerations for Nephrology Nurses. As nurses in dialysis providing a life-sustaining therapy, we are required to provide an essential service during pandemics and need to thrive in the uncertainty. 2020-04-30
Guidance for management of cancer surgery during the COVID-19 pandemic. This article provides general guidance on supporting curative surgical treatment where appropriate and with available resources. 2020-04-30
The impact of the novel coronavirus on trauma and orthopaedics in the UK. Orthopaedic surgeons are not generally considered front-line staff in terms of the treatment of the disease that the novel coronavirus causes compared with anaesthetic and medical colleagues. 2020-04-29
COVID-19 in Tuberculosis patients: a report of three cases. The clinical features and treatment of pulmonary tuberculosis patients with COVID-19 is unclear and understudied. […] We provide information and experience with treatment of pulmonary tuberculosis cases with confirmed COVID-19 infection. 2020-04-28
The application of Temporary Ark Hospitals in controlling COVID-19 spread: the experiences of one Temporary Ark Hospital, Wuhan, China. Over the period of operation, a total of 1,124 patients were admitted for treatment. 2020-04-28
A Novel Plan to Deal with SARS-CoV-2 and COVID-19 Disease. While this makes financial sense, from a medical perspective our population will be left defenseless in the absence of a viable treatment strategy for SARS-CoV-2. 2020-04-28
Three Taiwan’s domestic family cluster infections of coronavirus disease 2019. Third, when the second and third clusters could not find infectious sources, CECC’s press conference let the public know immediately the epidemic situation, so that people could raise their awareness and seek medical treatment or quarantine. 2020-05-11
Special considerations for elderly patients with head and neck cancer during the COVID-19 pandemic. Elderly patients with head and neck cancer are at increased risk of adverse outcomes during and after treatment of head and neck cancer. […] In many cases, prudent treatment plan modification may allow for overall best outcomes. […] Furthermore, recruitment of social services and, when appropriate, palliative care, may allow for optimal management of these patients. 2020-05-29
Salivary gland disease in the era of COVID-19 pandemic. These changes raise a lot of questions regarding patient triage and treatment decisions in clinical situations when it is unclear if the workup and management can be postponed. 2020-05-29
Medication for COVID-19-an Overview of Approaches Currently Under Study. These include virustatic agents that have already been approved for the treatment of other types of viral infection, as well as drugs that are currently used for entirely different purposes. […] Because the virus enters human cells by way of the membrane-associated angiotensin converting enzyme 2 (ACE2), keeping the virus from docking to this receptor is a conceivable treatment approach. […] There is not yet any recommendation for the therapeutic use of any particular agent beyond standard supportive treatment. 2020-05-01
Sex-specific clinical characteristics and prognosis of coronavirus disease-19 infection in Wuhan, China: A retrospective study of 168 severe patients. Sex is an important biological variable that should be considered in the prevention and treatment of COVID-19. 2020-05-13
Use of Tocilizumab for COVID-19-Induced Cytokine Release Syndrome: A Cautionary Case Report. Anti-cytokine therapy such as tocilizumab, an IL-6 receptor antagonist, is a potential treatment for COVID-19; however, data regarding the efficacy of this anti-IL-6 therapy are currently lacking. […] Both patients progressed to sHLH despite treatment with tocilizumab, and one developed viral myocarditis, challenging the safety and clinical usefulness of tocilizumab in the treatment of COVID-19-induced CRS. 2020-05-06
Mild versus severe COVID-19: Laboratory markers. Treatment in intensive care units (ICU) has become a major challenge; therefore, early recognition of severe forms is absolutely essential for timely triaging of patients. 2020-05-29
Eosinophil responses during COVID-19 infections and coronavirus vaccination. Eosinophil levels vary dramatically in a number of clinical settings, especially following eosinophil-targeted therapy, which is now available to selectively deplete these cells. 2020-05-24
COVID-19 pandemic-a focused review for clinicians. Here we provide an update for clinicians on the recent developments in the virology, diagnostics, clinical presentation, viral shedding, and treatment options for COVID-19 based on current literature. […] We describe the virological characteristics of SARS-CoV-2 and the clinical course of COVID-19 with an emphasis on diagnostic challenges, duration of viral shedding, severity markers and current treatment options. […] For improved management of cases, there is a need to understand test probability of serology, qRT-PCR and radiological testing, and the efficacy of available treatment options that could be used in severe cases with a high risk of mortality. 2020-05-22
Impact of immune enhancement on Covid-19 polyclonal hyperimmune globulin therapy and vaccine development. Vaccines that prevent SARS-CoV-2 infection and therapeutics that reduces the risk of severe Covid-19 are thus urgently needed. […] A rapid method to derive antiviral treatment for Covid-19 is the use of convalescent plasma derived hyperimmune globulin. 2020-05-29
COVID-19: Disease, management, treatment, and social impact. Despite great efforts, there is no treatment of this disease. […] This article describes SARS-CoV-2, disease, prevention and management, treatment and social impact on society. […] However, Unani therapy may be useful along with allopathic treatment. 2020-05-19
May patients receiving 5-alpha-reductase inhibitors be in higher risk of COVID-19 complications? Based on this observation, our proposed hypothesis is that 5-alpha-reductase inhibitors, that are commonly used for BPH treatment, may be one of the factors contributing to poorer prognosis in males. 2020-05-18
Respiratory conditions in coronavirus disease 2019 (COVID-19): Important considerations regarding novel treatment strategies to reduce mortality. Alternate treatment strategies utilizing clinically available treatments such as hyperbaric oxygen therapy (HBOT), packed red blood cell (pRBC) transfusions, or erthropoiesis-stimulating agent (ESA) therapy were hypothesized to increase oxygenation of tissues by alternative means than standard respiratory and ventilator treatments. […] It was also revealed that alternative treatments currently being considered for COVID-19 such as chloroquine and hydroxychloroquine by increasing hemoglobin production and increasing hemoglobin availability for oxygen binding and acetazolamine (for the treatment of altitude sickness) by causing hyperventilation with associated increasing levels of oxygen and decreasing levels of carbon dioxide in the blood may significantly ameliorate COVID-19 respiratory symptoms. […] In conclusion, is recommend, given HBOT, pRBC, and ESA therapies are currently available and routinely utilized in the treatment of other conditions, that such therapies be tried among COVID-19 patients with serious respiratory conditions and that future controlled-clinical trials explore the potential usefulness of such treatments among COVID-19 patients with respiratory conditions. 2020-05-18
Can pioglitazone be potentially useful therapeutically in treating patients with COVID-19? Despite the immense and ongoing global effort, no efficacious drugs to fight this plague have been identified and patients admitted to the intensive care units (ICU), for respiratory distress, are managed mostly by means of supportive care based on oxygen maintenance. […] TZD were widely used for type-2 diabetes in the first decade of this century and although concerns have been raised for possible side effects associated with long-term treatment, their use has been recently revaluated for their anti-inflammatory properties in numerous medical conditions. 2020-05-18
The clinical course and its correlated immune status in COVID-19 pneumonia. The dynamic levels of T lymphocyte in severe group were significantly lower from disease onset, but in the improved subgroup the value of T lymphocyte began to increase after about 15-day treatment and finally returned to the normal level. 2020-05-27
Impact of COVID-19 on Nuclear Medicine in Germany, Austria and Switzerland: An International Survey in April 2020. Questions were addressing the following issues: impact on nuclear medicine diagnostics and therapy, use of recommendations, personal protective equipment, and organizational adaptations. 2020-04-28
[COVID-19-Response - Strategies of the Task-Force Coronavirus and experiences upon implementation in the management of 115 cases at the University Medical Center Freiburg]. We also report on experiences with implementation of these approaches and treatment outcomes in the first 115 COVID patients. […] A multidisciplinary Task-force Coronavirus initiated measures concerning outpatient testing and counseling, reorganisation and separation of patient flow processes alongside with substantial escalation of inpatient capacities on regular wards and intensive care units. 2020-05-22
General Guidelines in the Management of an Obstetrical Patient on the Labor and Delivery Unit during the COVID-19 Pandemic. As such, clinical protocols and practice on labor and delivery units must adapt to optimize the safety of patients and health care workers and to better conserve health care resources. 2020-04-28
[The COVID-19 Pandemia and its consequences for plastic surgery and hand surgery]. For both, plastic and hand surgeons it is crucial to act responsible, minimize the transmission of the virus and aid in reasonable and adequate allocation of resources for the treatment of affected patients during this pandemia. 2020-04-28
Finding the dose for hydroxychloroquine prophylaxis for COVID-19; the desperate search for effectiveness. Hydroxychloroquine is an antimalarial drug being tested as a potential treatment for the novel coronavirus disease 2019 (COVID-19) pandemic caused by the severe acute respiratory syndrome coronavirus 2( (SARS-CoV-2. 2020-04-28
Neuraxial anaesthesia and peripheral nerve blocks during the COVID-19 pandemic: a literature review and practice recommendations. These recommendations focus on seven specific domains including: planning of resources and staffing; modifying the clinical environment; preparing equipment, supplies and drugs; selecting appropriate personal protective equipment; providing adequate oxygen therapy; assessing for and safely performing regional anaesthesia procedures; and monitoring during the conduct of anaesthesia and post-anaesthetic care. 2020-05-14
DIC in COVID-19: Implications for Prognosis and Treatment? So far, no causative therapy nor protective vaccines are available. […] In this situation, useful prognostic parameters and targeted supportive treatment are urgently needed. 2020-04-28
COVID-19 and RAS: Unravelling an Unclear Relationship. Previous evidence suggests that RAS may represent an important target for the treatment of lung pathologies, especially for acute respiratory distress syndrome and chronic fibrotic disease. 2020-05-01
A Novel Combination of Vitamin C, Curcumin and Glycyrrhizic Acid Potentially Regulates Immune and Inflammatory Response Associated with Coronavirus Infections: A Perspective from System Biology Analysis. Since no specific therapy for these CoVs is available, any beneficial approach (including nutritional and dietary approach) is worth investigation. 2020-05-29
Clinical characteristics of patients with 2019 coronavirus disease in a non-Wuhan area of Hubei Province, China: a retrospective study. We retrospectively analyzed the clinical characteristics and treatment progress of 91 patients diagnosed with COVID-19 in Jingzhou Central Hospital. 2020-04-30
COVID-19: Key Concepts for the Surgeon. In view of the current pandemic by SARS-CoV-2 it deems essential to understand the key concepts about the infection: its epidemiological origin, presentation, clinical course, diagnosis and treatment (still experimental in many cases). 2020-05-01
Treatment for emerging viruses: Convalescent plasma and COVID-19. This convalescent plasma therapy is of particular interest when a vaccine or specific therapy is not yet available for emerging viruses, such as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which causes COVID-19. […] It also includes recommendations for establishing a convalescent plasma program, enhancement considerations for convalescent plasma, and considerations around pathogen reduction treatment of convalescent plasma. […] The immediate use of convalescent plasma provides prompt availability of a promising treatment while specific vaccines and treatments are evaluated and brought to scale. […] Further development of improved convalescent plasma, vaccines and other therapeutics depends on quick generation of additional data on pathogenesis and immune response. 2020-05-05
Treatment of Proximal Femoral Fragility Fractures in Patients with COVID-19 During the SARS-CoV-2 Outbreak in Northern Italy. Unprepared for this emergency, hospitals have quickly reformulated paths of assistance in an effort to guarantee treatment for infected patients. […] Orthopaedic departments have been focused on elderly traumatology, especially the treatment of femoral neck fractures in patients with coronavirus disease-2019 (COVID-19). […] The purpose of the present study was to evaluate the orthopaedic management strategy for femoral fragility fractures in COVID-19-positive patients with the hypothesis that operative treatment may contribute to the overall stability of the patient. […] Four patients who underwent surgical treatment died of respiratory failure on the first day after surgery (1 patient), the third day after surgery (2 patients), or the seventh day after surgery (1 patient). […] We noted a stabilization of respiratory parameters in 12 COVID-19-positive patients who underwent surgery treatment of proximal femoral fractures. 2020-05-16
Cancer care in the time of COVID-19-a perspective from Pakistan. This paper discusses the impact of coronavirus infection on cancer diagnosis and treatment in two leading cancer centres in Pakistan. […] There is an urgent need to evaluate the effect of delays in diagnosis and treatment on cancer stage and treatment, and to decide how to minimise these during likely future cycles of lockdown over the coming months and years. 2020-05-01
Additional challenges faced by cancer patients in Gaza due to COVID-19. Cancer patients in conflict settings experience significant barriers in accessing chemotherapy and radiotherapy as well as palliative care and psychosocial support. 2020-05-01
Experimental Treatment with Favipiravir for COVID-19: An Open-Label Control Study. No specific treatment has been reported. […] Herein, we examine the effects of Favipiravir (FPV) versus Lopinavir (LPV)/ritonavir (RTV) for the treatment of COVID-19. […] In this open-label nonrandomized control study, FPV showed significantly better treatment effects on COVID-19 in terms of disease progression and viral clearance; if causal, these results should be important information for establishing standard treatment guidelines to combat the SARS-CoV-2 infection. 2020-05-01
Expert recommendations on blood purification treatment protocol for patients with severe COVID-19: Recommendation and consensus. The second step is to prescribe a blood purification treatment for patients with COVID-19. 2020-05-01
Clinical and imaging features of COVID-19. This paper reviews the published literature, guidelines and consensus, and summarizes the clinical and imaging characteristics of COVID-19, in order to provide a reliable basis for early diagnosis and treatment. 2020-05-11
Implementation of a Novel Remote Physician SBRT Coverage Process during the Coronavirus Pandemic. We implemented a novel remote RO SBRT coverage practice, requiring it to be reliable, of high audio and visual quality, timely, and the same level of specialty care as our current in-person treatment coverage practice. […] The time from CBCT to treatment was calculated before and after implementation to determine timeliness of remote coverage. […] Comfort levels with audio/visual communication as well as overall comfort in comparison to in-person RO coverage was evaluated using Likert scale surveys after treatment. […] Remote RO SBRT coverage was successfully implemented in 14/15 fractions with 3 observed process failures that were all corrected before treatment. […] Average times of pre-treatment coverage before and after implementation were 8.74 and 8.51min, respectively. 2020-05-01
Epidemiological and clinical features of asymptomatic patients with SARS-CoV-2 infection. The demographic characteristics, clinical data, treatment, and outcomes of SARS-CoV-2 infected patients without any symptoms were analyzed. 2020-05-13
[Diagnosis, treatment, control and prevention of SARS-CoV-2 and coronavirus disease 2019: back to the future]. Since SARS-CoV-2 and SARS-CoV are closely related, previous findings on SARS-CoV are highly relevant to a better understanding as well as diagnosis, treatment, prevention and control of SARS-CoV-2. […] In this review, we highlight recent progresses in the field; compare the biological characteristics of SARS-CoV and SARS-CoV-2; summarize the urgently-needed diagnostic, treatment, prevention and control options; and provide future perspectives for the outcome of the outbreak and research questions to be answered, including some of the difficulties in vaccine development. 2020-05-01
Clinical characteristics of coronavirus disease (COVID-19) early findings from a teaching hospital in Pavia, North Italy, 21 to 28 February 2020. Predictors of lower odds of discharge were age > 65 years, antiviral treatment and for severe disease, lactate dehydrogenase > 300 mg/dL. 2020-05-04
Redesigning a Department of Surgery during the COVID-19 Pandemic. The department of surgery played a leading role in establishing clinical protocols, guidelines, and policies in preparation for a surge of COVID-19 patients. 2020-05-05
The Effect of Chloroquine, Hydroxychloroquine and Azithromycin on the Corrected QT Interval in Patients with SARS-CoV-2 Infection. Small studies have shown a potential benefit of chloroquine/hydroxychloroquine ± azithromycin for the treatment of COVID-19. […] The maximum QTc during treatment was significantly longer in the combination group vs the monotherapy group (470.4 ± 45.0 ms vs. […] Although use of these medications resulted in QT prolongation, clinicians seldomly needed to discontinue therapy. 2020-04-29
Ethical aspects of the COVID-19 crisis: How to deal with an overwhelming shortage of acute beds. The current outbreak of SARS-CoV-2 has and continues to put huge pressure on intensive care units (ICUs) worldwide. 2020-05-29
The danger of neglecting melanoma during the COVID-19 pandemic. For the dermatology community, this interruption to the healthcare system can lead to delays in the diagnosis and treatment of melanoma. 2020-05-13
National Response to COVID-19 in the Republic of Korea and Lessons Learned for Other Countries. Identified strategies included early recognition of the threat and rapid activation of national response protocols led by national leadership; rapid establishment of diagnostic capacity; scale-up of measures for preventing community transmission; and redesigning the triage and treatment systems, mobilizing the necessary resources for clinical care. 2020-05-04
The experience of treating patients with acute myocardial infarction under the COVID-19 epidemic. Worldwide Coronavirus Disease 2019 (COVID-19) epidemic makes the management of acute myocardial infarction (AMI) more complicated, effective treatment without further dissemination is thus quite challenging. 2020-05-01
Skull base surgery during the Covid-19 pandemic: The Italian skull base society recommendations. Furthermore, elective clinics and operations have been reduced in order to mobilize manpower to the acute specialties combatting the outbreak; appropriate differentiation between patients who require immediate care and those who can receive telephone consultation or whose treatment might viably be postponed is therefore crucial. 2020-04-29
[SARS-CoV-2 infection and solid organ transplantation]. Furthermore, treatment options against COVID-19 disease and adequate adjustment of immunosuppression in at risk patients remain a concern. 2020-05-01
[Oncology: navigating the COVID-19 Pandemic and Steer the Course]. Proper mitigation strategies in the clinic and use of less resource-heavy but equivalent treatment alternatives often allow optimal cancer care. 2020-05-01
[Hematology in the time of COVID-19]. Thrombocytopenia and procoagulant state are associated with severe courses of COVID-19, requiring an individualized therapy. 2020-05-01
[Rheumatology and COVID-19]. Patients under immunosuppressive treatment are considered at high risk of severe outcome and are protected accordingly by the Swiss authorities. […] However, current, scarce scientific evidence suggests that patients under immunosuppressive therapy do not necessarily develop severe COVID-19 presentations. […] Therefore, the current guidelines recommend pursuing the treatment throughout the pandemic. 2020-05-01
[COVID-19 : Intensive care management]. Up to 5 % of COVID-19 infected patients develop severe acute hypoxemic respiratory failure requiring invasive mechanical ventilation as supportive treatment. […] Apart from early antiviral and anti-inflammatory treatment, the management of COVID-19 patients is mainly applying protective mechanical ventilation, to support the injured lungs. 2020-05-01
[Organizational Impacts and Clinical Challenges of the COVID-19 Pandemic on a Swiss Tertiary Internal Medicine Department]. Alongside organizational challenges, clinical issues such as rapid respiratory distress, clinical suspicions with negative PCR and treatment uncertainties in the absence of sufficient evidence were overcome. 2020-05-01
Effects Of ARBs And ACEIs On Virus Infection, Inflammatory Status And Clinical Outcomes In COVID-19 Patients With Hypertension: A Single Center Retrospective Study. With the capability of inducing elevated expression of ACE2, the cellular receptor for SARS-CoV-2, angiotensin II receptor blockers or angiotensin-converting enzyme inhibitors (ARBs/ACEIs) treatment may have a controversial role in both facilitating virus infection and reducing pathogenic inflammation. […] 126 COVID-19 patients with preexisting hypertension at Hubei Provincial Hospital of Traditional Chinese Medicine (HPHTCM) in Wuhan from January 5 to February 22, 2020 were retrospectively allocated to ARBs/ACEIs group (n=43) and non-ARBs/ACEIs group (n=83) according to their antihypertensive medication. 125 age- and sex-matched COVID-19 patients without hypertension were randomly selected as non-hypertension controls. […] In addition, the medication history of 1942 hypertension patients that were admitted to HPHTCM from November 1 to December 31, 2019 before COVID-19 outbreak were also reviewed for external comparison. 2020-04-29
A Patient with COVID-19 Disease in a Referral Hospital in Iran: A Typical Case. O2 saturation was 87% (without O2 therapy). 2020-04-29
Pulmonary Embolism and Increased Levels of d-Dimer in Patients with Coronavirus Disease. We report 3 patients with coronavirus disease who had a decline in respiratory status during their hospital course that responded well to intravenous steroids and interleukin-6 receptor antagonist therapy. 2020-04-29
Effect of Convalescent Plasma Therapy on Viral Shedding and Survival in COVID-19 Patients. Currently, the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) disease 2019 (COVID-19) has been reported in almost all countries globally, and no effective therapy has been documented for COVID-19 and the role of convalescent plasma therapy is unknown. […] In conclusion, convalescent plasma treatment can discontinue SARS-CoV-2 shedding but cannot reduce mortality in critically end-stage COVID-19 patients, and treatment should be initiated earlier. 2020-05-06
Global reporting of cases of COVID-19 in psoriasis and atopic dermatitis: an opportunity to inform care during a pandemic. We wish to bring your attention to the PsoPROTECT (Psoriasis Patient Registry for Outcomes, Therapy and Epidemiology of Covid-19 infecTion) and SECURE-AD (Surveillance Epidemiology of Coronavirus Under Research Exclusion-Atopic Dermatitis) registries; two urgent global initiatives that address an unmet need for delineating the determinants of COVID-19 outcomes in the common cutaneous immune-mediated inflammatory diseases (IMIDs) psoriasis and atopic dermatitis. 2020-04-29
Ultrasound on the Frontlines of COVID-19: Report from an International Webinar. Imaging modalities such as chest radiography, thoracic and cardiovascular ultrasound, and computed tomography have roles in the diagnosis, prognosis, monitoring, and therapy of COVID-19. 2020-04-29
COVID-19 diagnosis and management: a comprehensive review. Here, we provide an overview of the known clinical features and treatment options for COVID-19. […] To date, there is no evidence of any effective treatment for COVID-19. […] The main therapies being used to treat the disease are antiviral drugs, chloroquine/hydroxychloroquine and respiratory therapy. […] Specifically designed randomized clinical trials are needed to determine the most appropriate evidence-based treatment modality. 2020-05-13
Review article: prevention, diagnosis and management of COVID-19 in the IBD patient. IBD medication adherence should be encouraged to prevent disease flare but where possible high-dose systemic corticosteroids should be avoided. […] The primary focus should remain on keeping bowel inflammation controlled and encouraging medication adherence. 2020-05-26
COVID-19 Related Genes in Sputum Cells in Asthma: Relationship to Demographic Features and Corticosteroids. Use of inhaled corticosteroids (ICS) was associated with lower expression of ACE2 and TMPRSS2, but treatment with triamcinolone acetonide (TA) did not decrease expression of either gene. 2020-05-22
Response and role of palliative care during the COVID-19 pandemic: A national telephone survey of hospices in Italy. Palliative care is an important component of health care in pandemics, contributing to symptom control, psychological support, and supporting triage and complex decision making. […] Concerns included scarcity of personal protective equipment, a lack of hospice-specific guidance on COVID-19, anxiety about needing to care for children and other relatives, and poor integration of palliative care in the acute planning response. […] Governments must urgently recognise the essential contribution of hospice and palliative care to the COVID-19 pandemic and ensure these services are integrated into the health care system response. 2020-05-15
Use of Radiographic Features in COVID-19 Diagnosis: Challenges and Perspectives. Radiographic technologies and tools, including Computed tomography (CT) and Chest X-ray (CXR), were applied for initial screening and follow-up, from which provides detail diagnosis with specific pathologic features for staging and treatment arrangement. 2020-04-29
Protection by Exclusion: Another Missed Opportunity to Include Pregnant Women in Research During the Coronavirus Disease 2019 (COVID-19) Pandemic. With limited ability to contain the virus and relatively high transmissibility and case fatality rates, governmental institutions and pharmaceutical companies are racing to find therapeutics and vaccines that target this novel coronavirus. […] This is another missed opportunity to obtain pregnancy-specific safety and efficacy data, because therapeutics developed for men and nonpregnant women may not be generalizable to pregnant women. 2020-05-26
Chloroquine and Hydroxychloroquine Retinal Toxicity Consideration in the Treatment of COVID-19. The proposed doses of chloroquine (CQ) and hydroxychloroquine (HCQ) for treatment of COVID-19 (1000 mg/day for 10 days, CQ; 800 mg first day then 400 mg/day for 5 days, HCQ) in many guidelines worldwide, are considerably higher than the maximum recommended daily safe doses of both agents (≤2.3 mg/kg/day, CQ; ≤5.0 mg/kg/day, HCQ) for development of retinal toxicity. 2020-05-01
Hypercoagulation and Antithrombotic Treatment in Coronavirus 2019: A New Challenge. The novel coronavirus 2019 (COVID-19) is clinically characterized by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which is responsible for a high number of patients needing mechanical ventilation or intensive care units treatment and for the elevated mortality risk. […] Furthermore, we discussed the biologic plausibility of the thrombotic risk in SARS-CoV-2 and the potential use of an antithrombotic treatment. 2020-04-29
Becoming a Faithful Defender: Traditional Chinese Medicine against Coronavirus Disease 2019 (COVID-19). So far, there is no specific anti-coronavirus therapy approved for the treatment of COVID-19. […] For a better popularization of TCM, governments have made several advances in regulations and policies for treatment and measures of novel coronavirus pneumonia (NCP). […] Therefore, on the basis of epidemiology and virology information, we reviewed relevant meta-analysis and clinical studies of anti-coronavirus therapeutics by TCM, in the aspect of mortality, symptom improvement, duration and dosage of corticosteroid, incidence of complications and the like. 2020-04-30
Toward a consensus view in the management of acute facial injuries during the Covid-19 pandemic. In these unprecedented times, OMFS surgeons are faced with dilemmas over the priority of treatment, safety of staff, safety of patients and the most appropriate use of available resources. 2020-05-02
Systemic sclerosis and the COVID-19 pandemic: World Scleroderma Foundation preliminary advice for patient management. Due to the frequent presence of interstitial lung disease and widespread use of immunosuppressive treatment, systemic sclerosis (SSc) patients may be considered at risk for a more severe disease course and higher mortality when they develop Severe Acute Respiratory Syndrome - Coronavirus - 2 (SARS-CoV-2) virus infection. 2020-05-22
Effective treatment of severe COVID-19 patients with tocilizumab. The patients diagnosed as severe or critical COVID-19 in The First Affiliated Hospital of University of Science and Technology of China (Anhui Provincial Hospital) and Anhui Fuyang Second People’s Hospital were given tocilizumab in addition to routine therapy between 5 and 14 February 2020. […] Within 5 d after tocilizumab, 15 of the 20 patients (75.0%) had lowered their oxygen intake, and 1 patient needed no oxygen therapy. […] The percentage of lymphocytes in peripheral blood, which decreased in 85.0% of patients (17/20) before treatment (mean, 15.52 ± 8.89%), returned to normal in 52.6% of patients (10/19) on the fifth day after treatment. […] Preliminary data show that tocilizumab, which improved the clinical outcome immediately in severe and critical COVID-19 patients, is an effective treatment to reduce mortality. 2020-05-22
[COVID-19 pandemic: structured expansion of ventilation capacities using home respirators]. Due to their limited technical features, home respirators are not suitable for the treatment of severely affected patients but can be used for weaning after respiratory improvement, which means that intensive care respirators are available again more quickly. 2020-05-11
Epidemiologic characteristics of traumatic fractures in elderly patients during the outbreak of coronavirus disease 2019 in China. The collected data included patients’ demographics (age and gender), injury-related (injury type, fracture location, injury mechanism, places where fracture occurred), and treatment modality. 2020-05-07
Anti COVID-19 Drugs: Need for More Clinical Evidence and Global Action. According to the WHO, Centers for Disease Control and Prevention (CDC), and the US Food and Drug Administration (FDA), currently there are no medicines or vaccines that have been claimed to be useful in the prevention or treatment of COVID-19. […] According to the CDC and Chinese treatment guidelines for COVID-19, chloroquine, hydroxychloroquine, lopinavir/ritonavir, and one of the investigational agents (remdesivir) are recommended in critically ill older patients. […] The use of other potential drugs reported in different studies may be considered if treatment with first-line drugs is ineffective. […] There are currently no complete data available from large randomized clinical trials (RCTs) to provide clinical guidance on the use, dosing, or duration to validate the effective role, safety profile, and adverse effects of all of the trial drugs for prophylaxis or treatment of COVID-19. 2020-05-29
Characterizing the Impact of COVID-19 on Men Who Have Sex with Men Across the United States in April, 2020. Some reported challenges in accessing HIV testing, prevention and treatment services. 2020-05-09
Use of CT and artificial intelligence in suspected or COVID-19 positive patients: statement of the Italian Society of Medical and Interventional Radiology. In this emergency situation, several expectations have been raised by the scientific community about the role that artificial intelligence can have in improving the diagnosis and treatment of coronavirus infection, and SIRM wishes to deliver clear statements to the radiological community, on the usefulness of artificial intelligence as a radiological decision support system in COVID-19 positive patients. 2020-05-13
It’s not over until it’s over: the chameleonic behavior of COVID-19 over a six-day period. The current global outbreak of COVID-19 represents a major challenge in terms of epidemiology, contagiousness, treatment, as well as clinical and radiological behavior of this disease. 2020-05-13
Chloroquine-induced QTc prolongation in COVID-19 patients. In the battle against the SARS-CoV‑2 pandemic, chloroquine has emerged as a new potential therapeutic option for the treatment of infected patients. […] A baseline electrocardiogram (ECG) and ECGs recorded during chloroquine treatment were retrospectively collected in patients suspected of having COVID-19. […] A total of 95 patients had a baseline ECG recording and at least one ECG recording during chloroquine therapy. […] Chloroquine treatment resulted in a mean QTc prolongation of 35 ms (95% CI 28-43 ms) using computerised interpretation and 34 ms (95% CI 25-43 ms) using manual interpretation. […] No torsade de pointes was observed during chloroquine treatment. […] After manual review, 22 patients (23%) had a QTc interval exceeding 500 ms during chloroquine treatment. […] None of these patients had a prolonged QTc interval prior to the initiation of chloroquine treatment. 2020-05-25
Immediate and long-term impact of the COVID-19 pandemic on delivery of surgical services. No major stakeholder seems to have considered how a pandemic deprives patients with a surgical condition of resources, with patients disproportionally affected owing to the nature of treatment (use of anaesthesia, operating rooms, protective equipment, physical invasion and need for perioperative care). 2020-05-06
COVID-19: a defining moment for clinical pharmacology? COVID-19 may also be such a defining moment for clinical pharmacology in terms of its role in drug development and therapy. 2020-04-30
Rethinking the role of hydroxychloroquine in the treatment of COVID-19. In addition, the known and potent immunomodulatory effects of these agents which support their use in the treatment of auto-immune conditions, and provided a component in the original rationale for their use in patients with COVID-19, may, in fact, undermine their utility in the context of the treatment of this respiratory viral infection. […] Given these facts and the growing uncertainty about these agents for the treatment of COVID-19, it is clear that at the very least thoughtful planning and data collection from randomized clinical trials are needed to understand what if any role these agents may have in this disease. […] In this article, we review the datasets that support or detract from the use of these agents for the treatment of COVID-19 and render a data informed opinion that they should only be used with caution and in the context of carefully thought out clinical trials, or on a case-by-case basis after rigorous consideration of the risks and benefits of this therapeutic approach. 2020-05-06
Evidence for Use or Disuse of Renin-Angiotensin System Modulators in Patients Having COVID-19 With an Underlying Cardiorenal Disorder. This raises the question whether the use of RAS inhibitors, the backbone of treatment of cardiovascular, neurovascular, and kidney diseases could increase the susceptibility for coronavirus infection or unfortunate outcomes of COVID-19. 2020-05-25
Initial experiences from patients with COVID-19 on ventilatory support in Denmark. COVID-19 patients have characteristic reproducible laboratory findings and present a major challenge due to their illness severity and required treatment length. none. not relevant. 2020-05-01
A Coronavirus Disease 2019 (COVID-19) Patient with Multifocal Pneumonia Treated with Hydroxychloroquine. Hydroxychloroquine therapy was started, and the patient responded favorably with improvement of symptoms. 2020-05-05
Will the antimalarial drug take over to combat COVID-19? To systematically review and evaluate the pattern of COVID-19 and the treatment plans. […] The current research taking place to overcome this complex disease and the urgent need to develop improved therapeutics are also discussed. […] Herein, we present an epidemiological overview of the currently available information on the treatment claimed to have helped to bring the situation under control. 2020-05-05
Infection Control for CT Equipment and Radiographers’ Personal Protection During the Coronavirus Disease (COVID-19) Outbreak in China. OBJECTIVE. Because CT plays an important role in diagnosis, isolation, treatment, and effective evaluation of coronavirus disease (COVID-19), infection prevention and control management of CT examination rooms is important. CONCLUSION. We describe modifications to the CT examination process, strict disinfection of examination rooms, arrangement of waiting areas, and efforts to increase radiographers’ awareness of personal protection made at our institution during the COVID-19 outbreak. 2020-04-30
Clinical features, laboratory characteristics, and outcomes of patients hospitalized with coronavirus disease 2019 (COVID-19): Early report from the United States. Presenting signs and symptoms, laboratory and imaging findings, treatment, and complications were recorded from electronic medical records (EMRs). 2020-05-05
Insights for increased risk of failed fibrinolytic therapy and stent thrombosis associated with COVID-19 in ST-segment elevation myocardial infarction patients. Due to extended transportation delays to a cathlab, he received intravenous fibrinolytic therapy, which failed. […] Reperfusion was achieved with rescue coronary angioplasty, but the patient experienced two episodes of acute stent thrombosis at 2- and 36-hr following admission and despite optimal medical therapy. 2020-04-30
Association of Obesity with Disease Severity among Patients with COVID-19. Increased vigilance and aggressive treatment of patients with obesity and COVID-19 are warranted. 2020-04-30
[Options for controlling new Corona virus infection - 2019-nCoV]. Interferon-alpha (5 million U twice daily by inhalation), lopinavir/ritonavir (400/100 mg twice daily orally), as well as chloroquine (500 mg twice daily orally for 10 days) and azithromycin (500 mg twice per day) cause a milder course of the disease and reduce the duration of treatment. 2020-05-04
MANAGEMENT OF PERSISTENT PNEUMOTHORAX WITH THORACOSCOPY AND BLEBS RESECTION IN COVID-19 PATIENTS. Chest drain represent the first line treatment. 2020-05-02
COVID-19 and Nigeria: putting the realities in context. Nigeria’s current national health systems cannot effectively respond to the growing needs of already infected patients requiring admission into intensive care units for acute respiratory diseases and severe acute respiratory syndrome (SARS COV-2) pneumonia. 2020-05-29
Severe Acute Respiratory Syndrome-Coronavirus-2 Infection and Patients With Lung Cancer: The Potential Role of Interleukin-17 Target Therapy. To our knowledge, this is the first reported investigation of a possible role of interleukin-17 target therapy in patients with lung cancer and concomitant severe acute respiratory syndrome-coronavirus-2 infection. 2020-05-16
Serum albumin-mediated strategy for the effective targeting of SARS-CoV-2. We are suggesting here a strategy for the COVID-19 treatment that could be effective in curing the patients in the current scenario when no efficient medicine or Vaccine is currently available, and Clinicians solely depend upon the performing trials with drugs with known antiviral activities. 2020-05-18
Occupational exposure to SARS-CoV-2 in burns treatment during the COVID-19 epidemic: Specific diagnosis and treatment protocol. Burns are an acute-care condition, and burn treatment needs to be initiated before COVID-19 infection status can be excluded. […] The key step to infection prevention is to identify risk points of infection exposure, strengthen the protection against those risk points, and formulate an appropriate diagnosis and treatment protocol. […] Following an in-depth study of the latest literature on COVID-19 diagnosis and treatment, we reviewed the protocols surrounding hospitalization of patients with extensive burns (area≥50 %) in our hospital from February 2009 to February 2019 and, in accordance with the epidemiological characteristics of COVID-19, developed an algorithm for protection during diagnosis and treatment of burns. […] Therefore, the aspects of medical protection and the diagnosis and treatment of burns appear to be particularly important during the prevention and control of the COVID-19. […] This algorithm was followed for 4 patients who received emergency treatment in February 2020 and were hospitalized. […] During the COVID-19 epidemic, the early stages of emergency treatment for patients with extensive burns requiring the establishment of venous access for rehydration, endotracheal intubation or tracheostomy, wound treatment, and surgery are the risk points for exposure to infection. […] The implementation of effective, appropriate-grade protection and formulation of practical treatment protocols can increase protection of healthcare worke and reduce the risk of COVID-19 infection exposure. 2020-05-21
The many faces of the anti-COVID immune response. Furthermore, treatment options for COVID-19 infection are currently limited. 2020-05-08
Functional Role of Dietary Intervention to Improve the Outcome of COVID-19: A Hypothesis of Work. Taking into consideration the mortality rate of COVID-19, about 5-7%, and the percentage of positive patients admitted to intensive care units being 9-11%, it should be mandatory to consider and take all necessary measures to contain the COVID-19 infection. […] Moreover, given the recent evidence in different hospitals suggesting IL-6 and TNF-α inhibitor drugs as a possible therapy for COVID-19, we aimed to highlight that a dietary intervention could be useful to prevent the infection and/or to ameliorate the outcomes during therapy. 2020-05-05
Twenty-Year Span of Global Coronavirus Research Trends: A Bibliometric Analysis. More research on prevention and treatment is needed according to an analysis of term density. 2020-05-06
The novel coronavirus (COVID-19) pneumonia with negative detection of viral ribonucleic acid from nasopharyngeal swabs: a case report. The patient received combination of interferonalfa-1b and ribavirin, lopinavir and ritonavir for antiviral treatment at different stages. […] Other medication was also given to him in combination for anti-inflammation, intestinal microbial regulation, phlegm elimination, liver protection and pulmonary fibrosis prevention purposes. […] We provided oxygen supply to him using BIPAP ventilator and high-flow humidification oxygen therapy instrument to facilitate respiration. […] This case report described an effective supportive medication scheme to treat SARS-COV-2 infected patient and emphasized the necessity of detection of the viral genome using BALF samples and its significance in the diagnosis and prognosis of the disease. 2020-05-04
Abdominal Wall Surgery After SARS-CoV-2: Time to Reestablish Postponed Non-essential Procedures? The hospital network of our public health system has provided most of the resources for the treatment of patients affected by the infection. 2020-05-03
A single center observational study of the clinical characteristics and short-term outcome of 20 kidney transplant patients admitted for SARS-CoV2 pneumonia. At admission, all had immunosuppression withdrawn and were started on methylprednisolone 16 mg/day, all but one was commenced on antiviral therapy and hydroxychloroquine with doses adjusted for kidney function. […] During a median follow-up of seven days, 87% experienced a radiological progression and among those 73% required escalation of oxygen therapy. 2020-05-27
COVID-19 infection in kidney transplant recipients. Overall, two were managed on an out-patient basis, but the remaining five required hospital admission, four in intensive care units. […] Most patients had their immunosuppression reduced and were treated with supportive therapy. 2020-05-28
Palliative care in the context of a pandemic: similar but different. Palliative care is an important component of the medical response to pandemics and other health emergencies. […] The principles of palliative care do not change, but the practice of palliative care has to change as a result of factors such as greater demand and infection control measures. […] This article makes suggestions for palliative care provision during a pandemic (in developed countries), based on a limited review of the literature and personal experience of the ongoing pandemic (COVID-19 infection). 2020-05-01
Acute myocardial injury is common in patients with covid-19 and impairs their prognosis. We prospectively assessed the medical records, laboratory results, chest CT images and use of medication in a cohort of patients presenting to two designated covid-19 treatment centres in Sichuan, China. […] Outcomes of interest included death, admission to an intensive care unit (ICU), need for mechanical ventilation, treatment with vasoactive agents and classification of disease severity. […] Patients with acute myocardial injury were older, with a higher prevalence of pre-existing cardiovascular disease and more likely to require ICU admission (62.5% vs 24.7%, p=0.003), mechanical ventilation (43.5% vs 4.7%, p<0.001) and treatment with vasoactive agents (31.2% vs 0%, p<0.001). 2020-05-01
Cardiovascular manifestations and treatment considerations in covid-19. Specific cardiovascular considerations are also necessary in supportive treatment with anticoagulation, the continued use of renin-angiotensin-aldosterone system inhibitors, arrhythmia monitoring, immunosuppression or modulation, and mechanical circulatory support. 2020-05-14
Outcomes of COVID-19 in 79 patients with IBD in Italy: an IG-IBD study. Patients with IBD are at increased risk of infection, especially when they have active disease and are taking immunosuppressive therapy. […] Data regarding age, sex, IBD (type, treatments and clinical activity), other comorbidities (Charlson Comorbidity Index (CCI)), signs and symptoms of COVID-19 and therapies were compared with COVID-19 outcomes (pneumonia, hospitalisation, respiratory therapy and death). […] Thirty-six patients had COVID-19-related pneumonia (46%), 22 (28%) were hospitalised, 7 (9%) required non-mechanical ventilation, 9 (11%) required continuous positive airway pressure therapy, 2 (3%) had endotracheal intubation and 6 (8%) died. 2020-05-28
Considerations for STI Clinics during the COVID-19 pandemic. It is important to balance the need for access to healthcare services, including testing and treatment for sexually transmitted infections (STIs). 2020-05-01
A quasi-experiment on using guided mobile learning interventions in ESL classrooms: Time use and academic performance. These data were compared to the results of the tests conducted pre- and post-treatment. […] However, treatment group students who spent more time using mobile devices to learn the language did not display better performance compared to those who spent minimal time. 2020-05-01
[Antibiotics alone as an alternative to appendectomy for uncomplicated acute appendicitis in adults: changes in treatment modalities related to the COVID-19 health crisis]. Indeed, while the currently recommended treatment for uncomplicated acute appendicitis is surgical appendectomy, the non-surgical alternative of medical management by antibiotic therapy alone has been widely evaluated by high-quality studies in the literature. […] Insofar as the main limitation of exclusively medical treatment of uncomplicated acute appendicitis is the risk of recurrent appendicitis, this treatment option represents an alternative of choice to reduce the intra-hospital overload in this context of health crisis.The aim of this work is therefore to provide physicians and surgeons with a practical guide based on a review of the literature on the medical treatment of uncomplicated acute appendicitis in adults, to offer this alternative treatment to the right patients and under good conditions, especially when access to the operating room is limited or impossible. 2020-05-01
Consideration of dornase alfa for the treatment of severe COVID-19 acute respiratory distress syndrome. Dornase alfa should be considered for clinical trials in treatment of severe COVID-19. 2020-05-21
What Does the COVID-19 Pandemic Mean for Rheumatology Patients? They are concerned about their risk of developing COVID-19 as many are immune suppressed from their disease and/or treatment, whether they should stop their advanced therapies, if they will have a worse outcome if/when infected due to their underlying medication condition(s) and if they will have drug availability, especially with press (without much data) coverage suggesting hydroxychloroquine may be used in COVID-19 infection causing diversion of medication supply. […] The long term effects of the pandemic in patients with rheumatic diseases will not be known until much later and likely include stressors flaring disease (fear, illness, job loss, social isolation), post-traumatic stress, flaring due to stopping medications, less physician visits with subsequent under-treatment, and increases in chronic concomitant fatigue, pain, fibromyalgia. 2020-05-01
Comprehensive update on current outbreak of novel coronavirus infection (2019-nCoV). Unfortunately, like the previous Coronavirus outbreaks, there is no definite antiviral therapy for the treatment of confirmed cases and hence preventing ourselves from contracting 2019-nCoV is the best way to prevent it from becoming pandemic. […] Herein, we aim to discuss the latest updates on the origin, genomic characteristics, diagnosis, treatment options and current efforts being made by international health organizations with regards to the 2019-nCoV outbreak. 2020-05-05
COVID-19: Therapeutics and Their Toxicities. These two medications may precipitate ventricular dysrhythmias, necessitating cardiac and electrolyte monitoring, and in severe cases, treatment with epinephrine and high-doses of diazepam. […] Recombinant protein therapeutics may cause serum sickness or immune complex deposition. […] Here, we review the use, mechanism of action, and toxicity of proposed COVID-19 therapeutics. 2020-05-08
[Public Mental Health as One of the Key Factors in Dealing with COVID-19]. Past outbreaks of infectious diseases (Ebola and Zika virus) have shown that maladaptive behavior, related to increased psychological stress and anxiety, can interfere with the implementation of treatment strategies and actions and can contribute to a further spread. 2020-05-29
Cardiovascular Disease, Drug Therapy, and Mortality in Covid-19. Using an observational database from 169 hospitals in Asia, Europe, and North America, we evaluated the relationship of cardiovascular disease and drug therapy with in-hospital death among hospitalized patients with Covid-19 who were admitted between December 20, 2019, and March 15, 2020, and were recorded in the Surgical Outcomes Collaborative registry as having either died in the hospital or survived to discharge as of March 28, 2020. 2020-05-09
Renin-Angiotensin-Aldosterone System Inhibitors and Risk of Covid-19. We assessed the relation between previous treatment with ACE inhibitors, angiotensin-receptor blockers, beta-blockers, calcium-channel blockers, or thiazide diuretics and the likelihood of a positive or negative result on Covid-19 testing as well as the likelihood of severe illness (defined as intensive care, mechanical ventilation, or death) among patients who tested positive. […] Using Bayesian methods, we compared outcomes in patients who had been treated with these medications and in untreated patients, overall and in those with hypertension, after propensity-score matching for receipt of each medication class. […] There was no association between any single medication class and an increased likelihood of a positive test. 2020-05-16
The role of imaging in the detection and management of COVID-19: a review. Lung infection or pneumonia is the common complication of COVID-19, and imaging techniques, especially computed tomography (CT), have played an important role in diagnosis and treatment assessment of the disease. […] CT, positron emission tomography - CT (PET/CT), lung ultrasound, and magnetic resonance imaging (MRI) have been used for detection, treatment, and follow-up. 2020-05-01
Risk of QT Interval Prolongation Associated With Use of Hydroxychloroquine With or Without Concomitant Azithromycin Among Hospitalized Patients Testing Positive for Coronavirus Disease 2019 (COVID-19). Administration of hydroxychloroquine with or without azithromycin for the treatment of coronavirus disease 2019 (COVID-19)-associated pneumonia carries increased risk of corrected QT (QTc) prolongation and cardiac arrhythmias. […] In this cohort study, patients who received hydroxychloroquine for the treatment of pneumonia associated with COVID-19 were at high risk of QTc prolongation, and concurrent treatment with azithromycin was associated with greater changes in QTc. […] Clinicians should carefully weigh risks and benefits if considering hydroxychloroquine and azithromycin, with close monitoring of QTc and concomitant medication usage. 2020-05-06
Mathematical modeling of interaction between innate and adaptive immune responses in COVID-19 and implications for viral pathogenesis. Based on our analysis, delaying the onset of adaptive immune responses during the early phase of infections may be a potential treatment option for high-risk COVID-19 patients. 2020-05-13
Convalescent plasma transfusion for the treatment of COVID-19: Systematic review. This review was conducted to evaluate the effectiveness of CPT therapy in COVID-19 patients based on the publications reported till date. […] The main findings from available data are as follows: (a) Convalescent plasma may reduce mortality in critically ill patients, (b) Increase in neutralizing antibody titers and disappearance of SARS-CoV-2 RNA was observed in almost all the patients after CPT therapy, and (c) Beneficial effect on clinical symptoms after administration of convalescent plasma. […] Based on the limited scientific data, CPT therapy in COVID-19 patients appears safe, clinically effective, and reduces mortality. 2020-05-13
Clinical Pathway for Management of Suspected or Positive Novel Coronavirus-19 Patients With ST-Segment Elevation Myocardial Infarction. In the setting of anticipated resource scarcity in the future, we are forced to reconsider fibrinolytic therapy in our management algorithms. 2020-05-15
CLINICAL CHARACTERISTICS OF 28 PATIENTS WITH DIABETES AND COVID-19 IN WUHAN, CHINA. Epidemiologic, demographic, clinical, laboratory, treatment, and outcome data were analyzed. Results: The average age of the 28 patients was 68.6 ± 9.0 years. 2020-05-01
Advanced Pulmonary and Cardiac Support of COVID-19 Patients: Emerging Recommendations From ASAIO-a Living Working Document. Although extracorporeal membrane oxygenation and other modalities of mechanical cardiopulmonary support are increasingly being utilized in the treatment of respiratory and circulatory failure refractory to conventional management, their role and efficacy as support modalities in the present pandemic are unclear. […] We review the rapidly changing epidemiology, pathophysiology, emerging therapy, and clinical outcomes of coronavirus disease 2019; and based on these data and previous experience with artificial cardiopulmonary support strategies, particularly in the setting of infectious diseases, provide consensus recommendations from American Society for Artificial Internal Organs. 2020-05-05
Status and strategies for the management of head and neck cancer during COVID-19 pandemic: Indian scenario. Being semi-emergent in nature, treatment for these patients is currently on hold or delayed in most centers across the country. 2020-05-13
SARS-CoV-2 pandemic and repercussions for male infertility patients: A proposal for the individualized provision of andrological services. These groups include infertility patients (eg, azoospermic and cryptozoospermic) undergoing medical or surgical treatment to improve sperm quantity and quality, as well as males of reproductive age affected by inflammatory and systemic auto-immune diseases who are about to start treatment with gonadotoxic drugs or who are under remission. 2020-05-23
Changes in Head and Neck Oncologic Practice During the COVID-19 Pandemic. A questionnaire was distributed to head and neck surgeons assessing opinions related to treatment and concerns for the safety of patients, self, family, and staff. […] Surgeons continued to recommend primary surgical treatment for oral cavity cancers. […] Respondents were more likely to consider non-surgical therapy for patients with early glottic cancers and HPV-mediated oropharynx cancer. 2020-05-01
COVID-19 Deaths: Are We Sure It Is Pneumonia? Please, Autopsy, Autopsy, Autopsy! Due to the scientific community’s efforts, there is an increasing body of published studies describing the virus’ biology, its transmission and diagnosis, its clinical features, its radiological findings, and the development of candidate therapeutics and vaccines. […] Only by working with a complete set of histological samples obtained through autopsy can one ascertain the exact cause(s) of death, optimize clinical management, and assist clinicians in pointing out a timely and effective treatment to reduce mortality. […] Death can teach us not only about the disease, it might also help with its prevention and, above all, treatment. 2020-05-04
Repurposing Antiviral Protease Inhibitors Using Extracellular Vesicles for Potential Therapy of COVID-19. Current treatment plans are still under investigation due to a lack of understanding of COVID-19. […] Hence, repurposing these drugs with a proper formulation is needed to improve the safety and efficacy for COVID-19 treatment. 2020-05-05
COVID-19: A Geriatric Emergency. There is an urgent need to share expertise and clinical management skills with geriatricians as well as the need for early diagnosis to start treatment at the earliest convenience in the community, with the aim to avoid the collapse of intensive care units. 2020-05-04
Early intervention likely improves mortality in COVID-19 infection. Given this sense of randomness, and in the absence of a definitive treatment, medical professionals can feel helpless. 2020-05-02
Case Fatality Rate of Cancer Patients with COVID-19 in a New York Hospital System. Cancer patients are presumed to be at increased risk from COVID-19 infection fatality due to underlying malignancy, treatment-related immunosuppression, or increased comorbidities. 2020-05-06
PLASTIC SURGERY AND THE COVID-19 PANDEMIC: A REVIEW OF CLINICAL GUIDELINES. Specific recommendations were made for surgical treatment of cancer, trauma and semi-urgent reconstructive procedures based on available data and literature. 2020-05-15
Advanced Pulmonary and Cardiac Support of COVID-19 Patients: Emerging Recommendations From ASAIO-A “Living Working Document”. Although extracorporeal membrane oxygenation and other modalities of mechanical cardiopulmonary support are increasingly being utilized in the treatment of respiratory and circulatory failure refractory to conventional management, their role and efficacy as support modalities in the present pandemic are unclear. […] We review the rapidly changing epidemiology, pathophysiology, emerging therapy, and clinical outcomes of COVID-19; and based on these data and previous experience with artificial cardiopulmonary support strategies, particularly in the setting of infectious diseases, provide consensus recommendations from ASAIO. 2020-05-30
The American College of Nuclear Medicine Guidance on Operating Procedures for a Nuclear Medicine Facility During COVID-19 Pandemic. The threat of COVID-19 is particularly serious as there is no vaccine and no specific antiviral therapy. 2020-05-14
COVID-19 with cystic features on computed tomography: A case report. The patients continued to be given oxygen by mask and received antitussive, phlegm-dispelling treatment. 2020-05-06
Frequently asked questions regarding SARS-CoV-2 in cancer patients-recommendations for clinicians caring for patients with malignant diseases. Patients with malignant diseases are assumed to be at increased risk for a worse outcome of SARS-CoV-2 infection, and therefore, guidance regarding prevention and management of the infection as well as safe administration of cancer-therapy is required. 2020-05-07
COVID-19 outbreak in Italy: experimental chest X-ray scoring system for quantifying and monitoring disease progression. Although chest X-ray (CXR) is considered not sensitive for the detection of pulmonary involvement in the early stage of the disease, we believe that, in the current emergency setting, CXR can be a useful diagnostic tool for monitoring the rapid progression of lung abnormalities in infected patients, particularly in intensive care units. 2020-05-13
Radiographic severity index in COVID-19 pneumonia: relationship to age and sex in 783 Italian patients. Our results may help to identify the highest-risk patients and those who require specific treatment strategies. 2020-05-13
SARS-CoV-2 infection in a psoriatic patient treated with IL-17 inhibitor. Whilst the authors reported an infection that occurred during therapy with an IL-23 inhibitor, we would like to briefly report one that occurred during therapy with an IL-17 inhibitor. 2020-05-12
A rational roadmap for SARS-CoV-2/COVID-19 pharmacotherapeutic research and development. IUPHAR Review 29. In this review, we identify opportunities for drug discovery in the treatment of COVID-19 and in so doing, provide a rational roadmap whereby pharmacology and pharmacologists can mitigate against the global pandemic. 2020-05-08
Head and neck survivorship care in the times of the SARS-CoV-2 pandemic. There are three proposed major strategies to address care for patients with cancer in this SARS-CoV-2 pandemic with postponing treatment for those with stable cancer, increasing personal protection provisions for patients with cancer, and increasing monitoring if a patient becomes infected with SARS-CoV-2. 2020-05-02
Cutaneous sıde-effects of the potential COVID-19 drugs. A variety of repurposed drugs and investigational drugs such as remdesivir, chloroquine, hydroxychloroquine, ritonavir, lopinavir, interferon-beta, and other potential drugs have been studied for COVID19 treatment. 2020-05-22
Bacterial and fungal co-infection in individuals with coronavirus: A rapid review to support COVID-19 antimicrobial prescribing. On secondary analysis, 1450/2010 (72%) of patients reported received antimicrobial therapy. 2020-05-06
Longitudinal Change of SARS-Cov2 Antibodies in Patients with COVID-19. However, no significant difference in level of IgM and IgG antibody between positive and negative patients of nucleic acid test after treatment was found. 2020-05-06
Pilot prospective open, single-arm multicentre study on off-label use of tocilizumab in patients with severe COVID-19. No agent has yet been proven to be effective for the treatment of patients with severe COVID-19. […] Future controlled trials in patients with severe illness are urgently needed to confirm the definite benefit with IL-6 target therapy. 2020-05-29
Occurrence of SARS-CoV-2 during mycophenolate mofetil treatment for pemphigus. we read with great interest the article entitled "Should SARS-CoV-2 influence immunosuppressive therapy for autoimmune blistering diseases? […] This is the first report of COronaVIrus DIsease 2019 (COVID-19) in a patient affected by autoimmune blistering disease (ABD) during immunosuppressive treatment (i.e. azathioprine). […] The authors conclude that it is crucial to learn of more cases of ABD patients under immunosuppressive treatment who have developed COVID-19, in order to better quantify the risk of infection under immunosuppressive therapy. 2020-05-02
The first, holistic immunological model of COVID-19: implications for prevention, diagnosis, and public health measures. The delayed and strong adaptive immune response (high affinity IgM and IgG antibodies) that follows, causes severe inflammation and triggers mediator cascades (complement, coagulation, and cytokine storm) leading to complications often requiring intensive therapy and being, in some patients, fatal. […] This “quantitative and time-sequence dependent” model has several implications for prevention, diagnosis, and therapy of COVID-19 at all ages. 2020-05-02
A Rapid Systematic Review of Clinical Trials Utilizing Chloroquine and Hydroxychloroquine as a Treatment for COVID-19. With supportive care as the current mainstay of treatment, the fatality rate of COVID-19 is 6.9%. […] There are currently several trials assessing the efficacy of different antivirals as treatment. […] In this study, the literature currently available on CQ and HCQ as treatment of COVID-19 was surveyed using EMBASE, PubMed, Cochrane Library, MedRxiv, and one clinical trial registry. 2020-05-29
2019 Novel Coronavirus Disease (COVID-19) in patients with Inflammatory Bowel Diseases. Seven patients (58%) were on maintenance treatment with immunomodulators/biologics, of these 4 with combined therapy (33%). 2020-05-02
Urgent Guidance for Navigating and Circumventing the QTc-Prolonging and Torsadogenic Potential of Possible Pharmacotherapies for Coronavirus Disease 19 (COVID-19). With the possibility that a considerable proportion of the world’s population soon could receive COVID-19 pharmacotherapies with torsadogenic potential for therapy or postexposure prophylaxis, this document serves to help health care professionals mitigate the risk of drug-induced ventricular arrhythmias while minimizing risk of COVID-19 exposure to personnel and conserving the limited supply of personal protective equipment. 2020-05-06
Convalescent Plasma: Therapeutic Hope or Hopeless Strategy in the SARS-CoV-2 Pandemic. Specifically, it has been used in the treatment of many viral infections with varying degrees of clinical efficacy. 2020-05-05
Managing the COVID-19 Pandemic as a National Radiation Oncology Centre in Singapore. At the same time, delaying treatment such as radiotherapy in cancer patients can be detrimental. 2020-05-03
COVID-19 impact on timing of brachytherapy treatment and strategies for risk mitigation. The purpose of this study was to highlight the importance of timely brachytherapy treatment for patients with gynecologic, breast, and prostate malignancies, and provide a framework for brachytherapy clinical practice and management in response to the COVID-19 pandemic. […] There may be a significant negative impact on oncologic outcomes for patients with gynecologic malignancies who have a delay in the timely completion of therapy. […] Delay of prostate or breast cancer treatment may also impact oncologic outcomes. […] If a treatment delay is expected, endocrine therapy may be an appropriate temporizing measure before delivery of radiation therapy. […] Brachytherapy remains a critical treatment for patients and may shorten treatment time and exposure for some. […] Every effort should be made to ensure timely brachytherapy delivery for patients with gynecologic malignancies, and endocrine therapy may help temporize treatment delays for breast and prostate cancer patients. 2020-05-06
Characteristics of Endodontic Emergencies during Coronavirus Disease 2019 Outbreak in Wuhan. During this time, several patients requiring assessment and treatment of endodontic emergencies were directed to the School and Hospital of Stomatology at Wuhan University, Wuhan, China. […] Of the total patient visits during this period, 50.26% of visits were for endodontic treatment. […] Vital pulp therapy can advantageously reduce treatment time, resulting in a reduced risk of infection for vital pulp cases. 2020-05-26
Screening for active COVID-19 infection and immunization status prior to biologic therapy in IBD patients at the time of the pandemic outbreak. It is unclear whether a more aggressive clinical course might develop in asymptomatic COVID-19 infected subjects during biological therapy and current evidence does not support treatment suspension. […] However, during pandemic, the start of treatment with immunosuppressive drugs and biologics should be postponed whenever possible and based on an individual risk assessment. […] When clinical conditions and the disease activity do not allow a treatment delay, before starting a biological therapy, screening of IBD patients for COVID-19 active infection by RT-PCR should be advisable, even in absence of clinical suspicion. 2020-05-06
Antiviral activities of type I interferons to SARS-CoV-2 infection. Treatment with IFN-α or IFN-β at a concentration of 50 international units (IU) per milliliter reduces viral titers by 3.4 log or over 4 log, respectively, in Vero cells. […] The EC50 of IFN-α and IFN-β treatment is 1.35 IU/ml and 0.76 IU/ml, respectively, in Vero cells. […] Overall, our results demonstrate the potential efficacy of human Type I IFN in suppressing SARS-CoV-2 infection, a finding which could inform future treatment options for COVID-19. 2020-05-29
Arbidol: A potential antiviral drug for the treatment of SARS-CoV-2 by blocking trimerization of the spike glycoprotein. The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) pandemic is a global public health emergency, and new therapeutics are needed. […] It is hoped that knowledge of the potential drug target and mechanism of action of Arbidol will help in the development of new therapeutics for SARS-CoV-2. 2020-05-17
The Impact of Sociocultural Influences on the COVID-19 Measures-Reflections From Singapore. Palliative care providers play an important role in supporting their patients and family members in these difficult times. 2020-05-17
Cytokine storm intervention in the early stages of COVID-19 pneumonia. Guidelines for the diagnosis and treatment of SARS-CoV-2 infected pneumonia were first published January 30th, 2020; these guidelines recommended for the first time that cytokine monitoring should be applied in severely ill patients to reduce pneumonia related mortality. […] In view of the severe morbidity and mortality of COVID-19 pneumonia, we review the current understanding of treatment of human coronavirus infections from the perspective of a dysregulated cytokine and immune response. 2020-05-13
Acute Thrombosis of an Aortic Prosthetic Graft in a Patient with Severe COVID-19-Related Pneumonia. Antiretroviral therapy and prophylactic low molecular weight heparin treatment were initiated. […] In COVID-19 patients with prosthetic graft, an aggressive antithrombotic treatment could be considered to prevent such an event. 2020-05-16
COVID-19 presenting as stroke. Timely assessment and hyperacute treatment is the key to minimize mortality and morbidity of patients with acute stroke. 2020-05-06
2019 Novel coronavirus disease (COVID-19) in hemodialysis patients: A report of two cases. To analyze the diagnosis and treatment of patients with chronic renal failure complicated with novel coronavirus pneumonia, and to evaluate the effect of blood purification technology on the treatment and prognosis of such patients. […] Two patients received continuous venovenous hemodiafiltration (CVVHDF) every other day for 4-6 h everytime, in addition to the standard treatment. 2020-05-11
Epidemiological and clinical characteristics analysis of COVID-19 in the surrounding areas of Wuhan, Hubei Province in 2020. According to the Shiyan experience, early diagnosis with multiple swaps of the Q-PCR test and timely treatment can reduce the death rate. 2020-05-30
NSAIDs in patients with viral infections, including Covid-19: Victims or perpetrators? Since nowadays no scientific evidence establishes a correlation between NSAIDS and worsening of COVID-19, patients should be advice against any NSAIDs self-medication when COVID-19 like symptoms are present. 2020-05-30
Clinical and transmission dynamics characteristics of 406 children with coronavirus disease 2019 in China: A review. Collecting their data and forming a large sample for analysis is more conducive to the recognition, prevention and treatment of coronavirus disease 2019 in children. 2020-05-07
Alternative Multidisciplinary Management Options for Locally Advanced NSCLC During the Coronavirus Disease 2019 Global Pandemic. Patients with locally advanced NSCLC (LA-NSCLC) may require treatment in locations where resources are limited, and the prevalence of infection is high. […] Although guiding data is scarce, we present an expert thoracic oncology multidisciplinary (radiation oncology, medical oncology, surgical oncology) consensus of alternative strategies for the treatment of LA-NSCLC during a pandemic. […] The overarching goals of these approaches are the following: (1) reduce the number of visits to a health care facility, (2) reduce the risk of exposure to severe acute respiratory syndrome-coronavirus-2, (3) attenuate the immunocompromising effects of lung cancer therapies, and (4) provide effective oncologic therapy. […] Nonoperative options include chemotherapy, chemoimmunotherapy, and radiation therapy with sequential schedules that may or may not affect long-term outcomes in an era in which immunotherapy is available. […] Whenever radiation therapy is delivered without concurrent chemotherapy, hypofractionated schedules are appropriate. […] The risk of severe treatment-related morbidity and mortality is increased for patients undergoing treatment for LA-NSCLC during the COVID-19 pandemic. […] Adapting alternative treatment strategies as quickly as possible may save lives and should be implemented through communication with the multidisciplinary cancer team. 2020-05-19
Liu Shen capsule shows antiviral and anti-inflammatory abilities against novel coronavirus SARS-CoV-2 via suppression of NF-κB signaling pathway. At present, there is no specific antiviral treatment recommended for SARS-CoV-2 infection. […] The number of virions of SARS-CoV-2 was observed under transmission electron microscope after treatment with LS. […] These findings indicate that LS could inhibit SARS-CoV-2 virus infection via downregulating the expression of inflammatory cytokines induced virus and regulating the activity of NF-κB/MAPK signaling pathway in vitro, making its promising candidate treatment for controlling COVID-19 disease. 2020-05-31
Efficacy and safety of current therapeutic options for COVID-19 - lessons to be learnt from SARS and MERS epidemic: A systematic review and meta-analysis. This meta-analysis aimed at evaluating the efficacy and safety of current option of therapies for severe acute respiratory syndrome (SARS), Middle Eastern respiratory syndrome (MERS) besides COVID-19, in an attempt to identify promising therapy for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infected patients. […] We searched PubMed, EMBASE, Cochrane Library, China National Knowledge Infrastructure (CNKI), China Science and Technology Journal Database (VIP), and WANFANG DATA for randomized controlled trials (RCTs), prospective cohort, and retrospective cohort studies that evaluated therapies (hydroxychloroquine, lopinavir/ritonavir-based therapy, and ribavirin-based therapy, etc.) for SARS, MERS, and COVID-19. […] Compared with control treatment, anti-coronary virus interventions significantly reduced mortality (RR 0.65, 95% CI 0.44-0.96; I2 = 81.3%), remarkably ameliorate clinical improvement (RR 1.52, 95% CI 1.05-2.19) and radiographical improvement (RR 1.62, 95% CI 1.11-2.36, I2 = 11.0 %), without manifesting clear effect on virological eradication, incidence of ARDS, intubation, and AEs. 2020-05-30
Current targeted therapeutics against COVID-19: Based on first-line experience in China. Although many clinical trials are already underway and the majority of patients have received antiviral therapy based on medication experience with severe acute respiratory syndrome (SARS) and Middle East respiratory syndrome (MERS), and preliminary results from some clinical trials, there are no antiviral drugs proven to be effective currently. […] We summarize the current therapeutic medicines used in the clinic, hope to be able to provide some implications for clinical medication. 2020-05-30
Forecasting the timeframe of 2019-nCoV and human cells interaction with reverse engineering. Currently, no vaccine or approved medical treatment is available. 2020-05-19
Acute limb ischemia in patients with COVID-19 pneumonia. The data from all patients who had tested positive for COVID-19 and had presented with ALI requiring urgent operative treatment were collected in a prospectively maintained database. […] Operative treatment was performed in 17 patients (85%). […] The use of prolonged systemic heparin might improve surgical treatment efficacy, limb salvage, and overall survival. 2020-05-15
SARS-CoV-2 receptor ACE2-dependent implications on the cardiovascular system: From basic science to clinical implications. COVID-19 requires the collaboration of nearly 200 countries to curb the spread of SARS-CoV-2 while gaining time to explore and improve treatment options especially for cardiovascular disease (CVD) and immunocompromised patients, who appear to be at high-risk to die from cardiopulmonary failure. […] Thus, RAAS inhibitors, which may increase the expression levels of ACE2, are commonly used for the treatment of hypertension and CVD. […] We aim to provide a list of potential treatment options and a better understanding of why CVD is a high risk factor for COVID-19 susceptibility and further discuss the acute as well as long-term cardiac consequences. 2020-05-31
New understanding of the damage of SARS-CoV-2 infection outside the respiratory system. In this paper, we will systematically review the pathogenic features, transmission routes, and infection mechanisms of SARS-CoV-2, as well as any adverse effects on the digestive system, urogenital system, central nervous system, and circulatory system, in order to provide a theoretical and clinical basis for the diagnosis, classification, treatment, and prognosis assessment of SARS-CoV-2 infection. 2020-05-21
COVID-19 in Vietnam: A lesson of pre-preparation. At 213 confirmed cases under treatment and isolation, a range of interventions were enforced including intensive and expansive contact, mass testing, isolation, and sterilization. 2020-05-27
Predictive factors for disease progression in hospitalized patients with coronavirus disease 2019 in Wuhan, China. Clinical, laboratory, and treatment data were collected and analyzed from 111 hospitalized patients with laboratory-confirmed COVID-19 in Union Hospital. 2020-05-27
A cross-sectional study on mental health among health care workers during the outbreak of Corona Virus Disease 2019. The results showed that people without public health emergency treatment experience showed worse performance in mental health, resilience and social support, and tended to suffer from psychological abnormality on interpersonal sensitivity and photic anxiety. 2020-05-29
COVID-19 Rapid Guideline in Kidney Transplant Recipients. in the reports presented about COVID-19, patients receiving kidney transplantation have not been specifically studied and based on national flowchart, this population is classified as highrisk group, thus it is necessary to be aware of the step-by-step treatment approach of these patients. […] Suspicious cases included patients with a history of dry cough, chills or sore throat accompanying by shortness of breath with or without fever, patients with upper/lower respiratory symptoms with radiological manifestations as single or double-sided multilobular infiltrations on CT scan or plain chest radiography, any one that has a history of close contact with a definite COVID-19 case within the last 14 days, any one with a history of presence in COVID-19 epidemic regions within the last 14 days and patient with pneumonia that despite of proper treatment has an inappropriate clinical response and clinical condition becomes more severe in an unusual way or unexpectedly. 2020-05-06
Newly Diagnosed Glomerulonephritis During COVID-19 Infection Undergoing Immunosuppression Therapy, a Case Report. He was discharged healthy without development of new pulmonary symptoms despite immunosuppressive treatment. 2020-05-06
Clinical trials and the COVID-19 pandemic. For his experiment Galen used the random allocation of treatment, today’s prospective randomised clinical trial, implemented in the evaluation of novel therapies, widely used internationally, particularly in cancer research! […] COVID-19, caused by the SARS-CoV-2 new corona virus, brought to the fore the randomised trial, as well as, the ethical dilemmas that surround the allocation of treatment at random, in the face of a devastating pandemic. […] Is it his/her right to request the active treatment that a fellow patient is receiving in the next bed? […] Although the Declaration of Helsinki allows the option of no treatment or even placebo, where no known treatment is available for a certain condition, such as COVID-19, it also emphasizes that “while the primary purpose of medical research is to generate new knowledge, this goal can never take precedence over the rights and interests of individual research subjects”. […] In this brief instance of medical history, the equipoise, the scientific imperative, all arguments and other justifications for providing treatment at random, were thrown out of the window in favour of the human factor! […] Because-it is presumed-the process of randomising subjects, protects the study from the selective inclusion of patients with favourable characteristics, thus inadvertently allowing or facilitating a falsely favourable result for the drug or treatment under investigation. […] Since the middle of the 20th century a generation of physicians have been trained to dismiss, or are incapable of evaluating the validity of a treatment beyond the established etiquette of the randomised study. 2020-05-05
Risk Factors Associated with Clinical Outcomes in 323 COVID-19 Hospitalized Patients in Wuhan, China. Hypnotics may be an effective ancillary treatment for COVID-19. 2020-05-06
Development and validation of a UHPLC-MS/MS method for quantification of the prodrug remdesivir and its metabolite GS-441524: a tool for clinical pharmacokinetics of SARS-CoV-2/COVID-19 and Ebola virus disease. Remdesivir has received significant attention for its potential application in the treatment of COVID-19, caused by SARS-CoV-2. […] Remdesivir has already been tested for Ebola virus disease treatment and found to have activity against SARS and MERS coronaviruses. 2020-05-06
COVID-19, superinfections and antimicrobial development: What can we expect? Broad-spectrum antimicrobial use is likely to be widespread among hospitalized patients, both as directed and empiric therapy. […] Prospective studies on COVID-19 superinfections are needed, data from which can inform rational antimicrobial treatment and stewardship strategies, and models for market reform and sustainable drug development. 2020-05-06
Disruption of joint arthroplasty services in Europe during the COVID-19 pandemic: an online survey within the European Hip Society (EHS) and the European Knee Associates (EKA). Only life-threatening pathologies like periprosthetic fractures and acute septic TJA are currently undergoing surgical treatment. 2020-05-29
Correspondence: Importance of the validated serum biochemistry and hemogram parameters for rapid diagnosis and to prevent false negative results during COVID-19 pandemic. Rapid and effective diagnoses are vital for the isolation of infected people and starting treatment immediately to stop the spread of COVID-19 virus. 2020-05-21
Dupilumab and COVID-19: What should we expect? Therefore, the current data seem to suggest that treatment with dupilumab should not be stopped during COVID-19 pandemic. 2020-05-21
A PATH TO RESUME AESTHETIC CARE EXECUTIVE SUMMARY OF PROJECT AesCert™ GUIDANCE SUPPLEMENT: PRACTICAL CONSIDERATIONS FOR AESTHETIC MEDICINE PROFESSIONALS SUPPORTING CLINIC PREPAREDNESS IN RESPONSE TO THE SARS-CoV-2 OUTBREAK. Aesthetic providers will face new and unique challenges as government stay-at-home orders and related commercial limitations are eased, and the U.S. economy reopens and healthcare systems transition from providing only urgent and other essential treatment to resuming routine care and elective procedures and services. […] In a number of areas, this Guidance Supplement exceeds traditional aesthetic office safety precautions, recognizing reduced tolerance in an elective treatment environment for any risk associated with COVID-19’s highly variable presentation and unpredictable course. 2020-05-04
Quadruple therapy for asymptomatic COVID-19 infection patients. Whether asymptomatic patients are contagious or not and whether they need medication are the arguments among clinical experts.Areas covered: This paper reports a special asymptomatic couple with COVID-19, of which the male patient is an intercity bus driver but has not induced confirmed infection of his 188 passengers. […] Their clinical characteristics and medication were summarized and analyzed.Expert opinion: The two asymptomatic patients far away from Wuhan did not seem to be highly contagious. […] They improved obviously, after treatment with the quadruple therapy, but the effective drug is still unknown. 2020-05-14
Understanding the binding affinity of noscapines with protease of SARS-CoV-2 for COVID-19 using MD simulations at different temperatures. Our research group has established that noscapine is a chemotherapeutic agent for the treatment of drug resistant cancers; however, noscapine was also being used as anti-malarial, anti-stroke and cough-suppressant. 2020-05-14
An investigation into the identification of potential inhibitors of SARS-CoV-2 main protease using molecular docking study. Currently, several clinical trials are underway to identify specific drugs for the treatment of this novel virus. 2020-05-20
The role of triage in the prevention and control of COVID-19. The diagnosis of COVID-19 was based on positive COVID-19 nucleic acid testing according to the unified triage standards of the Guidelines for the Diagnosis and Treatment of Novel Coronavirus Pneumonia (Trial version 4),4 issued by the National Health Commission of the People’s Republic of China. 2020-05-20
Safe and informed prescribing of psychotropic medication during the COVID-19 pandemic. Treatment with psychotropic medication may sometimes be jeopardised because of the COVID-19 pandemic. 2020-05-28
Association Between Clinical Manifestations and Prognosis in Patients with COVID-19. Clinical, laboratory, and radiologic results, as well as treatment outcome data, were obtained. […] A total of 70 patients underwent CT imaging repeatedly after treatment. […] High body mass index (OR, 1.285; p = 0.017) and tobacco smoking (OR, 16.13; p = 0.032) were independent risk factors associated with disease exacerbation after treatment. 2020-05-06
Antibiotics alone as an alternative to appendectomy for uncomplicated acute appendicitis in adults: Changes in treatment modalities related to the COVID-19 health crisis. Indeed, while the currently recommended treatment for uncomplicated acute appendicitis is surgical appendectomy, the non-surgical alternative of medical management by antibiotic therapy alone has been widely evaluated by high-quality studies in the literature. […] Insofar as the main limitation of exclusively medical treatment of uncomplicated acute appendicitis is the risk of recurrent appendicitis, this treatment option represents an alternative of choice to reduce the intra-hospital overload in this context of health crisis. […] The aim of this work is therefore to provide physicians and surgeons with a practical guide based on a review of the literature on the medical treatment of uncomplicated acute appendicitis in adults, to offer this alternative treatment to the right patients and under good conditions, especially when access to the operating room is limited or impossible. 2020-05-06
Epidemiologic and clinical characteristics of heart transplant recipients during the 2019 coronavirus outbreak in Wuhan, China: A descriptive survey report. All cases were mild and successfully recovered after proper treatment. 2020-05-07
Therapeutic potential of ciclesonide inahalation for COVID-19 pneumonia: Report of three cases. No specific and effective anti-viral treatment has been approved for COVID-19 so far. […] Systemic corticosteroid has been sometimes administered to severe infectious diseases combined with the specific treatment. […] However, as lack of the specific anti-SARS-CoV-2 drug, systemic steroid treatment has not been recommended for COVID-19. […] Rationale of the treatment is to mitigate the local inflammation with inhaled steroid that stays in the lung and to inhibit proliferation of the virus by antiviral activity. 2020-05-20
Lopinavir/ritonavir combination therapy amongst symptomatic coronavirus disease 2019 patients in India: Protocol for restricted public health emergency use. Hospitalized adult patients with laboratory-confirmed SARS-CoV-2 infection with any one of the following criteria will be eligible to receive lopinavir/ritonavir for 14 days after obtaining written informed consent: (i) respiratory distress with respiratory rate ≥22/min or SpO2of <94 per cent; (ii) lung parenchymal infiltrates on chest X-ray; (iii) hypotension defined as systolic blood pressure <90 mmHg or need for vasopressor/inotropic medication; (iv) new-onset organ dysfunction; and (v) high-risk groups - age >60 yr, diabetes mellitus, renal failure, chronic lung disease and immunocompromised persons. […] Treatment outcomes amongst initial cases would be useful in providing guidance about the clinical management of patients with COVID-19. 2020-05-06
Insights into the inhibitory potential of selective phytochemicals against Mpro of 2019-nCoV: a computer-aided study. Until now there is no effective treatment or drug present to control its life-threatening effects in the humans. 2020-05-07
COVID-19, Modern Pandemic: A Systematic Review From Front-Line Health Care Providers’ Perspective. The main aim of this systematic review is to provide a comprehensive clinical summary of all the available data from high-quality research articles relevant to the epidemiology, demographics, trends in hospitalization and outcomes, clinical signs and symptoms, diagnostic methods and treatment methods of COVID-19, thus increasing awareness in health care providers. 2020-05-07
Recommended prophylactic and management strategies for severe acute respiratory syndrome coronavirus 2 infection in transplant recipients. Based on the current epidemic situation, this study reviewed publications on this virus and coronavirus disease 2019 (COVID-19), analyzed common features of respiratory viral pneumonias, and presented the currently reported clinical characteristics of COVID-19 in transplant recipients to improve strategies regarding the diagnosis and treatment of COVID-19 in this special population. 2020-05-07
The Inadequacy of Regulatory Frameworks in Time of Crisis and in Low-Resource Settings: Personal Protective Equipment and COVID-19. This generated a remarkable race to find solutions for the prevention, treatment and management of this disease which is involving a large amount of people. 2020-05-07
Crystal structure of SARS-CoV-2 nucleocapsid protein RNA binding domain reveals potential unique drug targeting sites. Currently, there is no specific viral protein-targeted therapeutics. 2020-05-14
Chloroquine: Can it be a Novel Drug for COVID-19. The United States Food and Drug Administration has not approved any drug or vaccine for the treatment of COVID-19; however, reports have emerged from different parts of the world about the potential therapeutic benefits of existing drugs. 2020-05-07
Review: Hydroxychloroquine and Chloroquine for Treatment of SARS-CoV-2 (COVID-19). We call for additional randomized controlled trial evidence prior to the widespread incorporation of hydroxychloroquine and chloroquine into national and international treatment guidelines. 2020-05-04
Binding site analysis of potential protease inhibitors of COVID-19 using AutoDock. Re-purposing the available protease inhibitor drugs for immediate use in treatment in SARS-CoV-2 infections could improve the currently available clinical management. 2020-05-07
An overview of coronaviruses including the SARS-2 coronavirus - Molecular biology, epidemiology and clinical implications. A cluster of patients were admitted with unusual pneumonia not responding to treatment in various hospitals. 2020-05-07
The clinical and immunological features of pediatric COVID-19 patients in China. The clinical features and treatment outcomes of twelve paediatric patients confirmed as COVID-19 were analyzed. […] All patients received antiviral and symptomatic treatment and the symptom relieved in 3-4 days after admitted to hospital. 2020-05-07
Cardiovascular Collapse in COVID-19 Infection: The Role of Veno-Arterial Extracorporeal Membrane Oxygenation (VA-ECMO). We reviewed existing literature surrounding the role of VA-ECMO in the treatment of coronavirus-related cardiovascular collapse. […] The decision to initiate this therapy should take into consideration availability of resources, perceived benefit as well as risks of transmitting disease. 2020-05-07
Medical treatment options for COVID-19. Here, we discuss the potential of these therapies for the treatment of coronavirus disease 2019. 2020-05-29
Mucous membrane pemphigoid and COVID-19 treated with high-dose intravenous immunoglobulins: a case report. This is a report of a case with mucous membrane pemphigoid (MMP) with severe eye involvement and concurrent COVID-19 treated successfully using simultaneous high dose intravenous immunoglobulin (IVIg) and anti-viral treatment as hydroxychloroquine, lopinavir/ritonavir, and ribavirin. 2020-05-15
FDA-approved thiol-reacting drugs that potentially bind into the SARS-CoV-2 main protease, essential for viral replication. Given the absence of a current vaccine or specific antiviral treatment, it is urgent to search for FDA-approved drugs that can potentially inhibit essential viral enzymes. […] Although, captopril is shown to be a potential ligand of 3CLpro, it is not recommended anti-COVID-19 therapy, due to the fact that it can induce the expression of the viral cellular receptor such as, angiotensin-converting enzyme ACE-2, and thus, making the patient potentially more susceptible to infection. 2020-05-20
Response of a comprehensive cancer center to the COVID-19 pandemic: the experience of the Fondazione IRCCS-Istituto Nazionale dei Tumori di Milano. While healthcare systems need to cope with the need to treat a large number of people with different degrees of respiratory failure, actions to preserve aliquots of the healthcare system to guarantee treatment to patients are mandatory. […] Of these, 47 were hospitalized, 53 needed a differential diagnosis to continue with their cancer treatment, and 201 were about to undergo surgery. 2020-05-04
Using integrated computational approaches to identify safe and rapid treatment for SARS-CoV-2. So far, however, there no effective treatment has been found to stop this new generation of coronavirus but discovering of the crystal structure of SARS-CoV-2 main protease (SARS-CoV-2 Mpro) may facilitate searching for new therapies for SARS-COV-2. […] The current study provides a powerful in silico results, means for rapid screening of drugs as anti-protease medications and recommend that the above-mentioned drugs can be used in the treatment of SARS-CoV-2 in combined or sole therapy.Communicated by Ramaswamy H. 2020-05-20
The BMA COVID-19 ethical guidance: a legal analysis. The paper considers the recently published British Medical Association Guidance on ethical issues arising in relation to rationing of treatment during the COVID-19 Pandemic. […] It considers whether it is lawful to create policies for the rationing and withdrawal of treatment, and goes on to consider how such policies might apply in practice. […] Legal analysis is undertaken of certain aspects of the Guidance which appear to misunderstand the law in respect of withdrawing treatment. 2020-05-18
Impact of SARS-CoV-2 infection on neurodegenerative and neuropsychiatric diseases: a delayed pandemic? Research is currently focused on understanding the acute infection and developing effective treatment strategies. 2020-05-10
Immune environment modulation in pneumonia patients caused by coronavirus: SARS-CoV, MERS-CoV and SARS-CoV-2. Thus, taking control of changes in immune factors could be critical in the treatment of COVID-19. 2020-05-26
COVID-19 pneumonia in kidney transplant recipients-Where we are? A liver and kidney transplant patient with SARS-CoV-2 pneumonia without respiratory failure was treated in a clinical multimodal strategy consisting of symptomatic support therapy, immunosuppression reduction, use of anti-coronavirus drugs and heparin leading to a progressive improvement of patient symptoms till discharge. 2020-05-26
[Potential harms associated with 4-aminoquinoline treatment]. Hydroxychloroquine and chloroquine are currently being evaluated as treatment against COVID-19. 2020-05-07
Caution regarding potential changes in AVR practices during the COVID-19 pandemic. For patients with severe aortic stenosis, efforts to bring treatment to symptomatic patients amid this pandemic might lead to favored use of catheter based management using minimalist techniques that do not require these elements. 2020-05-04
The Human Coronavirus Disease COVID-19: Its Origin, Characteristics, and Insights into Potential Drugs and Its Mechanisms. Given the lack of registered clinical therapies or vaccines, many physicians and scientists are investigating previously used clinical drugs for COVID-19 treatment. […] Besides, we summarize the recently investigated drugs that constitute an option for COVID-19 treatment. 2020-05-05
Pharmacological (or Synthetic) and Nutritional Agonists of PPAR-γ as Candidates for Cytokine Storm Modulation in COVID-19 Disease. Thus, an immunomodulatory approach targeting the over-production of cytokines could be proposed for viral aggressive pulmonary disease treatment. 2020-05-07
COVID-19 Surface Persistence: A Recent Data Summary and Its Importance for Medical and Dental Settings. As this was a current study, there are still not many sources in the literature, and scientific strategies are moving towards therapy and diagnosis, rather than knowing the characteristics of the virus. 2020-05-08
Codon Usage and Phenotypic Divergences of SARS-CoV-2 Genes. Overall, our results suggest that the higher divergence observed for the latter three genes could represent a significant barrier in the development of antiviral therapeutics against SARS-CoV-2. 2020-05-07
COVID-19: Present and Future Challenges for Dental Practice. Realizing the severity of outcomes associated with this disease and its high rate of transmission, dentists were instructed by regulatory authorities, such as the American Dental Association, to stop providing treatment to dental patients except those who have emergency complaints. […] Dentists at all times should competently follow cross-infection control protocols, but particularly during this critical time, they should do their best to decide on the emergency cases that are indicated for dental treatment. […] This overview will address several issues concerned with the COVID-19 pandemic that directly relate to dental practice in terms of prevention, treatment, and orofacial clinical manifestations. 2020-05-08
Clinical Recommendations for Epistaxis Management During the COVID-19 Pandemic. Epistaxis is a common complaint in the general population, and its treatment is a common procedure in emergency departments. 2020-05-05
Defining Essential Services for Deaf and Hard of Hearing Children during the COVID-19 Pandemic. With no vaccine or definitive treatment, public health authorities have recommended a strategy of “social distancing,” reducing individual interaction, canceling elective procedures, and limiting nonessential services. […] Health care providers must determine what procedures are considered “elective,” balancing risk of treatment delays with that of coronavirus exposure to patient, family, and providers. 2020-05-05
Mesenchymal stem cells as a potential therapy for COVID-19. The number of severe cases has increased dramatically worldwide, while specific treatment options are scarce. […] In this commentary, we summarize the clinical trials of MSCs treatments on ALI/ARDS and raise MSCs as a hopefully alternative therapy for severe or critical COVID-19. 2020-05-07
COVID-19 and Avoiding Ibuprofen. How Good Is the Evidence? Ibuprofen is an over-the-counter medication that is used widely for the treatment of pain and fever during COVID-19 pandemic. 2020-05-23
Guidance for the management of adult patients with coronavirus disease 2019. This article summarized the understanding of the etiology, pathogenesis, epidemiology, clinical characteristics, diagnosis, treatment, rehabilitation, and prevention and control measures of COVID-19 based on the available data and anti-epidemic experience in China. 2020-05-05
A human monoclonal antibody blocking SARS-CoV-2 infection. Vaccines and targeted therapeutics for treatment of this disease are currently lacking. […] This cross-neutralizing antibody targets a communal epitope on these viruses and may offer potential for prevention and treatment of COVID-19. 2020-05-06
High risk of thrombosis in patients with severe SARS-CoV-2 infection: a multicenter prospective cohort study. All patients referred to 4 intensive care units (ICUs) from two centers of a French tertiary hospital for acute respiratory distress syndrome (ARDS) due to COVID-19 between March 3rd and 31st 2020 were included. […] Sixty-four clinically relevant thrombotic complications were diagnosed in 150 patients, mainly pulmonary embolisms (16.7%). 28/29 patients (96.6%) receiving continuous renal replacement therapy experienced circuit clotting. 2020-05-13
SARS-CoV-2 can induce brain and spine demyelinating lesions. High-dose steroid treatment allowed neurological and respiratory recovery. […] Prompt invasive treatment should be adopted to avoid hypoxic neurotoxicity and prevent CNS injuries. 2020-05-08
Impact of coronavirus disease 2019 (COVID-19) outbreak on outcome of myocardial infarction in Hong Kong, China. Apart from being an infectious disease, it may affect human behavior and healthcare resource allocation which potentially cause treatment delay in MI. 2020-05-05
[First case of COVID-19 treated with tocilizumab in Iceland]. He developed respiratory failure and was transferred to the intensive care unit where he received further treatment, including tocilizumab (IL-6 receptor inhibitor). 2020-05-06
Nasopharyngeal wash in preventing and treating upper respiratory tract infections: Could it prevent COVID-19? In rapid systematic review, we found studies showing some improvement in prevention and treatment of upper respiratory tract infections. 2020-05-05
Severe acute respiratory syndrome-coronavirus 2 and novel coronavirus disease 2019: An extraordinary pandemic. Currently, no effective therapy or vaccine is available to manage this illness. 2020-05-05
COVID-19 Dynamic Computed Tomography (CT) Performance and Observation of Some Laboratory Indicators. CONCLUSIONS The dynamic changes of CT images of lungs of COVID-19 patients, combined with the clinical manifestations and laboratory indicators of patients, can help guide clinical diagnosis and treatment. 2020-05-06
Neoadjuvant endocrine therapy for luminal breast cancer treatment: a first-choice alternative in times of crisis such as the COVID-19 pandemic. In this scenario, neoadjuvant endocrine treatment could be an appropriate alternative treatment for hormone receptor positive breast cancer (luminal-like tumours) in order to minimise hospital admissions and to delay elective surgeries. 2020-05-08
Quantifying the Impact of COVID-19 on Cancer Patients: A Technical Report of Patient Experience During the COVID-19 Pandemic at a High-volume Radiation Oncology Proton Center in New York City. Radiation therapy is another essential clinical service that cannot afford to suffer prolonged delays without compromising patient outcomes. […] Early action and guidance are therefore critical to minimize transmission events and ensure safe and timely delivery of radiation therapy. […] The purpose of this report is to describe the institutional patient experience and quantify the impact of treatment delays and interruptions over the first month of the COVID-19 outbreak. 2020-05-08
Pulmonary contusion mimicking COVID-19: A case report. On day 9 after conservative treatment, her condition was alleviated. 2020-05-08
The Indian perspective of COVID-19 outbreak. The present study review is on the general continent, virology, pathogenesis, global epidemiology, clinical presentation, diagnosis, treatment and control of COVID-19 with the reference to India. 2020-05-07
Are Clinicians Contributing to Excess African American COVID-19 Deaths? Unbeknownst to Them, They May Be. To address this racial disparity, we must apply a health equity lens and disaggregate data explicitly for African Americans, as well as other populations at risk for biased treatment in the health-care system. 2020-05-07
Guide for Nuclear Medicine Applications During the COVID-19 Outbreak. There is no publication involving protection measures for diagnostic and therapeutic procedures in nuclear medicine (NM) (appointment, patient acceptance, imaging and treatment procedures, disinfection etc). […] In cancer cases requiring urgent treatment, radionuclide treatment (RNT) should be planned according to the COVID-19 test result. 2020-05-14
Management of COVID-19: the risks associated with treatment are clear, but the benefits remain uncertain. The management of mild cases of confirmed infection is another point of controversy, as drugs which may be repurposed for COVID-19 treatment have significant, potentially irreversible toxic effects and their use in mild cases of a viral illness which is typically self-limited may be harmful. 2020-05-07
Can N95 Respirators Be Reused after Disinfection? How Many Times? At 85 °C, 30% RH, we were able to perform 50 cycles of heat treatment without significant changes in the filtration efficiency. […] At low humidity or dry conditions, temperatures up to 100 °C were not found to alter the filtration efficiency significantly within 20 cycles of treatment. […] Ultraviolet (UV) irradiation was a secondary choice, which was able to withstand 10 cycles of treatment and showed small degradation by 20 cycles. 2020-05-29
Considerations for Postacute Rehabilitation for Survivors of COVID-19. Third, guidelines for rehabilitation (physiotherapy, occupational therapy, speech-language pathology) following COVID-19 have been proposed with respect to recovery of the respiratory system as well as recovery of mobility and function. […] A thorough assessment and an individualized, progressive treatment plan which focuses on function, disability, and return to participation in society will help each patient to maximize their function and quality of life. 2020-05-21
Association of Use of Angiotensin-Converting Enzyme Inhibitors and Angiotensin II Receptor Blockers With Testing Positive for Coronavirus Disease 2019 (COVID-19). There have been recommendations to discontinue these medications, which are essential in the treatment of several chronic disease conditions, while, in the absence of clinical evidence, professional societies have advocated their continued use. […] However, further study in larger numbers of hospitalized patients receiving ACEI and ARB therapy is needed to determine the association with clinical measures of COVID-19 severity. 2020-05-14
Tocilizumab for the treatment of severe coronavirus disease 2019. However, it is not possible to ascertain which adverse events were directly related to tocilizumab therapy. 2020-05-11
Experiencing Community in a Covid Surge. The reasons for the consults are mostly familiar-surrogate decision-making, informed refusal of treatment, goals of care, defining futility. 2020-05-05
Individualized prediction nomograms for disease progression in mild COVID-19. A total of 344 patients with mild COVID-19 were included in the final analysis, 45 of whom progressed and needed high-flow oxygen therapy or mechanical ventilation after admission. 2020-05-18
Clinical Features of Patients with Coronavirus Disease 2019 (COVID-19) from a Designated Hospital in Beijing, China. On the basis of antiviral drugs, antibiotics treatment, appropriate dosage of corticosteroid and gamma globulin therapy significantly improve patients’ outcomes. […] Early identification and timely medical treatment are important to reduce the severity of patients with COVID-19. 2020-05-05
The management of coronavirus disease 2019 (COVID-19). The management of COVID-19 patients includes epidemiological risk and patient isolation; treatment entails general supportive care, respiratory support, symptomatic treatment, nutritional support, psychological intervention, etc. 2020-05-23
The Prevalence of Olfactory and Gustatory Dysfunction in COVID-19 Patients: A Systematic Review and Meta-analysis. Increased awareness of this fact may encourage earlier diagnosis and treatment, as well as heighten vigilance for viral transmission. 2020-05-05
Otolaryngologists’ Role in Redeployment During the COVID-19 Pandemic: A Commentary. With our skill set, otolaryngologists are poised to support various aspects of hospital wards, intensive care units, emergency departments, and beyond. 2020-05-05
“We’re Not Ready, But I Don’t Think You’re Ever Ready.” Clinician Perspectives on Implementation of Crisis Standards of Care. Respiratory therapists, intensivists, nursing leadership and the palliative care interdisciplinary team participated in focus groups. […] Key informant interviews were conducted with emergency management, respiratory therapy and emergency medicine. 2020-05-05
Neuro-oncology Management During the COVID-19 Pandemic With a Focus on WHO Grade III and IV Gliomas. In this consensus statement, an international group of experts present mitigation strategies and treatment guidance for patients suffering from high grade gliomas (HGG) during the coronavirus disease 2019 (COVID-19) pandemic. 16 international experts in the treatment of HGG contributed to this consensus-based practice recommendation including neuro-oncologists, neurosurgeons, radiation -oncologists and a medical physicist. […] Generally, treatment of neuro-oncological patients cannot be significantly delayed and initiating therapy should not be outweighed by COVID-19. […] We present detailed interdisciplinary treatment strategies for molecular subgroups in two pandemic scenarios, a scale-up phase and a crisis phase. […] This practice recommendation presents a pragmatic framework and consensus-based mitigation strategies for the treatment of HGG patients during the SARS-CoV-2 pandemic. 2020-05-29
COVID-19 Hangover: A Rising Tide of Alcohol Use Disorder and Alcohol-Associated Liver Disease. Liver transplantation (LT) centers should adapt to the pandemic by considering leniency to some LT candidates with ALD who cannot access appropriate alcohol treatment due to the current situation. 2020-05-09
Multi-tiered screening and diagnosis strategy for COVID-19: a model for sustainable testing capacity in response to pandemic. Without the ability to efficiently screen patients, hospitals are overwhelmed, potentially delaying treatment for other emergencies. […] Early screening and triage is achievable from the outset of a pandemic with point-of-care host immune response testing which will improve response time to clinical and public health actions.Key messagesDelayed testing deployment has led to uncertainty surrounding overall disease burden and community spread, severely hampering public health containment and healthcare system preparation efforts.A multi-tiered testing strategy incorporating rapid, host immune point-of-care tests can be used now and for future pandemic planning by effectively identifying patients at risk of disease thereby facilitating quarantine earlier in the progression of the outbreak during the weeks and months it can take for pathogen specific confirmatory tests to be developed, validated and manufactured in sufficient quantities.The ability to triage patients at the point of care and support the guidance of medical and therapeutic decisions, for viral isolation or confirmatory testing or for appropriate treatment of COVID-19 and/or bacterial infections, is a critical component to our national pandemic response and there is an urgent need to implement the proposed strategy to combat the current outbreak. 2020-05-21
SARS-CoV-2 RNA polymerase as target for antiviral therapy. An accurate evaluation of RdRps from different viruses may guide the development of new drugs or the repositioning of already approved antiviral drugs as treatment of SARS-CoV-2. 2020-05-11
Role of adjunctive treatment strategies in COVID-19 and a review of international and national clinical guidelines. To date, there is no specific anti-COVID-19 treatment. 2020-05-07
[Evolution of electro-convulsive therapy activity in France since the beginning of the COVID-19 pandemic]. We conducted a national online survey to assess the evolution of electroconvulsive therapy (ECT) in the different centres practicing this treatment. 65 responses from all over France were analysed. 2020-05-08
Ensuring mental health care during the SARS-CoV-2 epidemic in France: A narrative review. There are also major issues when referring patients with acute mental disorders to intensive care units. 2020-05-08
[Health professionals facing the coronavirus disease 2019 (COVID-19) pandemic: What are the mental health risks?] In France, this large-scale health crisis urgently triggered the restructuring and reorganization of health service delivery to support emergency services, medical intensive care units and continuing care units. 2020-05-08
Renin-angiotensin-aldosterone system and COVID-19 infection. Since the ACE2 (angiotensin-converting enzyme 2) enzyme is the receptor that allows SARS COV2 entry into cells, the fear was that pre-existing treatment with ACEi or ARB might increase the risk of developing severe or fatal severe acute respiratory syndrome in case of COVID-19 infection. 2020-05-08
International Liaison Committee on Resuscitation: COVID-19 consensus on science, treatment recommendations and task force insights. Consensus on Science and Treatment recommendations aim to balance the benefits of early resuscitation with the potential for harm to care providers during the COVID-19 pandemic. 2020-05-20
Family cluster of three recovered cases of pneumonia due to severe acute respiratory syndrome coronavirus 2 infection. Following treatment with oseltamivir and short-term methylprednisolone combined with symptomatic management, all three patients recovered within 3 weeks, as evidenced by the disappearance of their symptoms, clearance of pulmonary infiltrates and consecutive negative molecular diagnostic test findings. […] Our observations suggest the importance of preventing family transmission and the efficacy of current integrated treatment for mild/moderate pneumonia in COVID-19 cases. 2020-05-07
Cytokine Storm Drugs Move from CAR T to COVID-19. Early reports suggest that tocilizumab, an IL6 receptor-blocking antibody used to manage toxicities associated with chimeric antigen receptor T-cell therapy, may help control cytokine storms in people infected with COVID-19. 2020-05-06
Utility of extracorporeal membrane oxygenation in COVID-19. ECMO is a resource-intensive therapy that can be considered in highly selected patients. […] Expert centers should employ an evidence-based ARDS treatment algorithm and a multidisciplinary approach to recommending ECMO upon failure of conventional therapy. 2020-05-06
SARS-CoV-2 and myocardial injury: Few answers, many questions. The mechanism of SARS-CoV-2 and associated myocardial injury, whether SARS-CoV-2 patients with myocardial injury are a distinct population, and possible treatment options for myocardial injury associated with SARS-CoV-2 are unknown. 2020-05-06
Hydroxychloroquine use in the COVID-19 patient. Data on HCQ for treatment of coronavirus disease 2019 (COVID-19) are rapidly evolving. […] To date there is no evidence from randomized controlled trials that any single therapy improves outcomes in patients infected with COVID-19. […] There are also no clinical trial data supporting prophylactic HCQ therapy in COVID-19. […] Hydroxychloroquine (HCQ) use in patients with COVID-19 is being investigated examining prophylaxis, postexposure prophylaxis, and treatment regimens. 2020-05-06
PAP therapy increases the risk of transmission of COVID-19. Positive airway pressure (PAP) therapy is an open system that can generate contact, droplet, and airborne COVID-19 thereby increasing the risk of transmission of COVID-19 like other procedures such as tracheal intubation, noninvasive ventilation, and cardiopulmonary resuscitation. […] Medically prudent recommendations have been established for home use of PAP therapy in asymptomatic patients and patients with suspected or confirmed COVID-19. 2020-05-06
Keep cystic fibrosis patients out of the hospital. Based on expert opinion, strategies for outpatient management include use of elexacaftor-tezacaftor-ivacaftor to reduce pulmonary exacerbations, telemedicine, adherence to prescribed regimens, prompt and aggressive treatment of CF exacerbations, and communication about COVID-19 with patients with CF. 2020-05-06
Asthma increases risk of severity of COVID-19. During this pandemic, it is recommended that patients with asthma continue taking all controller inhalers and other asthma medication as prescribed to prevent exacerbations and limit outpatient clinic and emergency room exposure. 2020-05-06
The War on COVID-19 Pandemic: Role of Rehabilitation Professionals and Hospitals. The complications from COVID-19 can be reduced by (1) delivering interdisciplinary rehabilitation that is initiated early and continued throughout the acute hospital stay, (2) providing patient/family education for self-care after discharge from inpatient rehabilitation at either acute or subacute settings, and (3) continuing rehabilitation care in the outpatient setting, and at home through ongoing therapy either in-person or via telehealth. 2020-05-06
Encountering COVID-19 as Endocrinologists. As the global prevalence of diabetes continues to increase, patients with endocrine diseases such as diabetes mellitus and those who are on long-term corticosteroid therapy due to adrenal insufficiency or hypopituitarism are at risk for a poor prognosis of COVID-19. 2020-05-06
Cardiac safety of off-label COVID-19 drug therapy: a review and proposed monitoring protocol. More than 2,000,000 individuals worldwide have had coronavirus 2019 disease infection (COVID-19), yet there is no effective medical therapy. […] Multiple off-label and investigational drugs, such as chloroquine and hydroxychloroquine, have gained broad interest due to positive pre-clinical data and are currently used for treatment of COVID-19. […] Many antibiotics commonly used for the treatment of patients with COVID-19, for instance azithromycin, can also prolong QT interval. […] This review summarizes evidenced-based data regarding potential cardiac adverse effects due to off-label and investigational drugs including chloroquine and hydroxychloroquine, antiviral therapy, monoclonal antibodies, as well as common antibiotics used for the treatment of COVID-19. 2020-05-29
Crisis hits end-of-life care. The covid-19 pandemic has encouraged more people to make advance treatment decisions relating to CPR and ventilation, reports Clare Wilson. 2020-05-06
Chloroquine and hydroxychloroquine in the context of COVID-19. Chloroquine and closely related structural analogs, employed initially for the treatment of malaria, are now gaining worldwide attention due to the rapidly spreading pandemic caused by severe acute respiratory syndrome-coronavirus-2, named coronavirus disease (COVID) of 2019 (COVID-19). […] This review aims to present the available in vitro and clinical data for the role of chloroquine/hydroxychloroquine in COVID-19 and attempts to put them into perspective, especially in relation to the different risks/benefits particular to each patient who may require treatment. 2020-05-20
An Environmental and Health Perspective for COVID-19 Outbreak: Meteorology and Air Quality Influence, Sewage Epidemiology Indicator, Hospitals Disinfection, Drug Therapies and Recommendations. The current Opinion Paper is one of the first attempts, to my understanding, to summarize and integrate environmental and human health aspects related to the monitoring, fate and treatment solutions for COVID-19. 2020-05-08
Low dose lung radiotherapy for COVID-19 pneumonia. The rationale for a cost-effective anti-inflammatory treatment. Low dose radiotherapy (0,5 Gy), is an evidence-based anti-inflammatory treatment, that could modify the immune landscape in the lung affected of SARS-CoV-2 pneumonia, through macrophages polarization to alternatively activated Macrophages (M2 phenotype). […] LDRT is a cost-effective non-toxic treatment already available in most general hospitals. 2020-05-08
MSCs transplantation may be a potential therapeutic strategy for COVID-19 treatment. SARS-Cov-2 has a strong infection, and the mortality rate of severe patients after infection is high, but there is no effective treatment. […] In this short report, combined with the progress of preclinical and clinical research, we comment the efficacy of MSCs in the treatment of COVID-19. 2020-05-08
Efficacy of chloroquine and hydroxychloroquine in the treatment of COVID-19. The aim of this study was to indirectly investigate the efficacy of chloroquine and hydroxychloroquine for the treatment of COVID-19 by determining the prevalence of COVID-19 in malaria pandemic and non-pandemic nations. […] We sought evidence to support or refute the hypothesis that these drugs could show efficacy in the treatment of COVID-19. […] The studies on "COVID-19 and its allied treatment were found from World Health Organization (WHO), ISI-Web of Science, PubMed, EMBASE, Scopus, Google Scholar, and clinical trial registries. […] The search was based on keywords: antiviral drugs, chloroquine, hydroxychloroquine, COVID-19, COVID-19 treatment modalities, and coronavirus. […] The findings support the hypothesis that these drugs have efficacy in the treatment of COVID-19. 2020-05-08
Outbreak of COVID-19 infection in children: fear and serenity. There are currently no effective antiviral drugs treatment for the affected children. […] No sufficient results have been reached by the use of interferon (IFN), lopinavir/ritonavir, orbidol, and oseltamivir in the treatment of the coronaviruses infection. 2020-05-08
The viral, epidemiologic, clinical characteristics and potential therapy options for COVID-19: a review. Meanwhile, we analyzed the epidemiologic and clinical characteristics of COVID-19, in order to provide recommendations for present clinical treatments and inspirations for potential therapy options. 2020-05-08
Coronavirus disease 2019: a clinical review. Current researches on potentially effective treatment alternatives are discussed. 2020-05-08
An update on the status of COVID-19: a comprehensive review. Due to the high mortality rate and the lack of optimum therapeutics, it is crucial to understand the biological characteristics of the virus and its possible pathogenesis to respond to the SARS-CoV-2. […] Rapid diagnostics and effective therapeutics are also important interventions for the management of infection control. […] However, the rapid evolution of SARS-CoV-2 exerted tremendous challenges on its diagnostics and therapeutics. […] In this review, we focus on our current understanding of epidemiology, pathogenesis, diagnostics and therapeutics of coronavirus disease 2019 (COVID-19). 2020-05-08
Clinical display, diagnostics and genetic implication of novel Coronavirus (COVID-19) epidemic. We highlighted the role of HLA haplotype in virus infection as HLA typing will provide susceptibility information for personalized prevention, diagnosis, and treatment in future studies. 2020-05-08
Current practice and potential strategy in diagnosing COVID-19. Chinese Clinical Guidance for COVID-19 Pneumonia Diagnosis and Treatment (7th edition) by National Health Commission is recommended to follow as it provides detailed diagnostic procedures using currently available tools. 2020-05-08
Practical guidance for the management of adults with Immune Thrombocytopenia during the COVID-19 pandemic. Nor is there sufficient evidence base to conclude that alternative approaches to treatment are incorrect. 2020-05-06
Potential anti-SARS-CoV-2 drug candidates identified through virtual screening of the ChEMBL database for compounds that target the main coronavirus protease. The main protease (Mpro , also called 3-chymotrypsin-like protease) of SARS-CoV-2 is a potential target for treatment of COVID-19. 2020-05-29
Delivering Benefits at Speed Through Real-World Repurposing of Off-Patent Drugs: The COVID-19 Pandemic as a Case in Point. These examples also reveal the unlimited opportunity to future-proof our health care systems by proactively mining, synthesizing, cataloging, and evaluating the off-label treatment opportunities of thousands of safe, well-established, and affordable generic drugs. 2020-05-26
AGS Position Statement: Resource Allocation Strategies and Age-Related Considerations in the COVID-19 Era and Beyond. Members of the AGS Ethics Committee collaborated with interprofessional experts in ethics, law, nursing, and medicine (including geriatrics, palliative care, emergency medicine, and pulmonology/critical care) to conduct a structured literature review and examine relevant reports. 2020-05-14
Natural antiviral compound silvestrol modulates human monocyte-derived macrophages and dendritic cells. Outbreaks of infections with viruses like Sars-CoV-2, Ebola virus and Zika virus lead to major global health and economic problems because of limited treatment options. 2020-05-06
[Emergency department : COVID-19 crisis and organizational aspects]. Diagnosis is based on PCR from a nasopharyngeal swab and emergency treatment rely on oxygen therapy. 2020-05-08
[Diabetes and COVID-19 infection]. Antidiabetic therapy may need adjustments following usual sick day rules. […] Insulin therapy should be considered to treat any persistent hyperglycemia in patients hospitalized for an acute infection. 2020-05-08
Stress, anxiety, and depression levels in the initial stage of the COVID-19 outbreak in a population sample in the northern Spain. The authors propose psychological interventions for prevention and treatment in order to mitigate the pandemic’s psychological impacts. 2020-05-11
COVID-2019 associated overexpressed Prevotella proteins mediated host-pathogen interactions and their role in coronavirus outbreak. Prevotella may have role in COVID-2019 outbreak and should be given importance for understanding disease mechanisms and improving treatment outcomes. 2020-05-06
Exergames as Coping Strategies for Anxiety Disorders During the COVID-19 Quarantine Period. This article critically appraises the opportunities and challenges exergames present for the prevention and treatment of anxiety disorders in a home-based environment during the COVID-19 quarantine period. 2020-05-06
Structural Basis for Potent Neutralization of Betacoronaviruses by Single-Domain Camelid Antibodies. Because of the vital role that these S proteins play, they represent a vulnerable target for the development of therapeutics. […] These data provide a molecular basis for the neutralization of pathogenic betacoronaviruses by VHHs and suggest that these molecules may serve as useful therapeutics during coronavirus outbreaks. 2020-05-29
Pathophysiological characteristics and therapeutic approaches for pulmonary injury and cardiovascular complications of coronavirus disease 2019. Diverse clinical manifestations and laboratory abnormalities occur in patients with cardiovascular injury in COVID-19, characterizing the development of this complication, as well as providing clues to diagnosis and treatment. 2020-05-08
Fetal Diagnosis and Therapy during the COVID-19 Pandemic: Guidance on Behalf of the International Fetal Medicine and Surgery Society. The COVID-19 pandemic has stressed patients and healthcare givers alike and challenged our practice of antenatal care, including fetal diagnosis and therapy. 2020-05-06
Pneumomediastinum following intubation in COVID-19 patients: a case series. Here we present a series of five cases of severe pneumomediastinum requiring decompression therapy over a 7-day period in the current COVID-19 outbreak. 2020-05-06
Coronavirus Pandemic-Therapy and Vaccines. In this context, novel approaches in both gene therapy and vaccine development are essential. 2020-05-07
[Individualized treatment recommendations for lung cancer patients at different stages of treatment during the outbreak of 2019 novel coronavirus disease]. In order to achieve the overall victory over 2019 novel coronavirus disease epidemic, especially to prevent the disease recurrence from rebounding during the resumption of labor, the government has not loosened any control of personnel mobility, which has obviously affected the normal examination and treatment of lung cancer patients under the influence of this epidemic. […] It is necessary to provide more appropriate individualized treatment recommendations for patients with lung cancer based on the epidemic situation of the patient’s location and in combination with the patient’s own condition. […] Through active prevention of infection, timely conversion of treatment strategies, online and offline joint control, and positive psychological counseling, we do our best to help patients with lung cancer to survive this difficult period. 2020-05-11
Covid-19: implications for prehospital, emergency and hospital care in patients with acute coronary syndromes. This paper describes, besides general measures in times of a pandemic, also the necessary changes in the invasive diagnosis and treatment of patients presenting with different entities of acute coronary syndromes including structural adaptations (networks, spokes and hub centres) and therapeutic adjustments. 2020-05-29
Respiratory management in severe acute respiratory syndrome coronavirus 2 infection. There has been increasing sharing experience regarding the patient’s clinical features over the last weeks which has underlined the need for general guidance on treatment strategies. 2020-05-29
Human needs in COVID-19 isolation. The only resource is people themselves using self-help, self-medication and self-care. 2020-05-07
Repurposing of chloroquine and some clinically approved antiviral drugs as effective therapeutics to prevent cellular entry and replication of coronavirus. The reemergence of coronavirus prompts the need for the development of effective therapeutics to prevent the cellular entry and replication of coronavirus. 2020-05-20
Acute respiratory failure in COVID-19: is it “typical” ARDS? Thus, fully understanding the characteristics of COVID-19-related ARDS is conducive to early identification and precise treatment. 2020-05-11
Challenges in maintaining treatment services for people who use drugs during the COVID-19 pandemic. The impact of COVID-19 across health services, including treatment services for people who use drugs, is emerging but likely to have a high impact. […] Treatment services for people who use drugs provide essential treatment services including opiate agonist treatment and needle syringe programmes alongside other important treatment programmes across all substance types including withdrawal and counselling services. […] Ensuring ongoing supply of opiate treatment during these periods will require significant changes to how treatment is provided. […] Ensuring people who use drugs have access to drug treatment as well as access to screening and testing for SARS-CoV2 where this is indicated is important. 2020-05-11
[Informations on psychotropics and their adaptations for patients suffering from mental disorders in France during the SARS-CoV-2 epidemic]. If there is no curative treatment for infection to SARS-CoV-2, the interactions of the various molecules currently tested with several classes of psychotropic drugs (antidepressants, antipsychotics) are important to consider because of the risk of changes in cardiac conduction. 2020-05-09
Angiotensin-Converting Enzyme 2 and Antihypertensives (Angiotensin Receptor Blockers and Angiotensin-Converting Enzyme Inhibitors) in Coronavirus Disease 2019. Given their equal efficacy but fewer adverse events, ARBs could potentially be a more favorable treatment option in patients with COVID-19 at higher risk for severe forms of disease. 2020-05-09
Resource Reallocation during the COVID-19 Pandemic in a Suburban Hospital System: Implications for Outpatient Hip and Knee Arthroplasty. The rapid surge of patients presenting over a small period for emergent clinical care, admission to the hospital, and intensive care units with many requiring mechanically assisted ventilators for respiratory support demonstrated the potential to overwhelm health care workers, hospitals, and health care systems. 2020-05-09
Palliative Care in the Time of COVID-19. Family members of patients admitted to the acute palliative care unit and hospice were screened for a period of two weeks. 2020-05-22
An In-hospital Pathway for Acute Coronary Syndrome Patients During the COVID-19 Outbreak: Initial Experience Under Real-World Suboptimal Conditions. For this reason, the Government of Lombardy decided to centralize the treatment of ACS patients in a limited number of centers, including our university cardiology institute, which in the past 4 weeks became a cardiovascular emergency referral center in a regional hub-and-spoke system. 2020-05-09
Immunomodulatory therapy for the management of severe COVID-19. Beyond the anti-viral therapy: A comprehensive review. Furthermore, we must keep in mind that currently, no specific antiviral treatment is available for SARS-CoV-2. […] While moderate-severe forms need in-hospital surveillance plus antivirals and/or hydroxychloroquine; in severe and life-threating subsets a high intensity anti-inflammatory and immunomodulatory therapy could be a therapeutic option. 2020-05-29
Seven recommendations to rescue the patients and reduce the mortality from COVID-19 infection: An immunological point of view. Severe patients are hospitalized and the treatment is done, though they have not been established yet. […] Currently, however, no treatment is provided for those who are isolated at home or shelter until they get severe symptoms, which will increase the harms to the patients. 2020-05-30
Transcriptional landscape of SARS-CoV-2 infection dismantles pathogenic pathways activated by the virus, proposes unique sex-specific differences and predicts tailored therapeutic strategies. As no specific therapeutics are yet available to control disease evolution, more in-depth understanding of the pathogenic mechanisms induced by SARS-CoV-2 will help to characterize new targets for the management of COVID-19. 2020-05-29
[Management and prevention of common skin problems during epidemic prevention and control of COVID-19]. It is therefore essential to provide timely treatment opinions and prevention methods for common skin problems. 2020-05-08
[Consensus of Chinese experts on diagnosis and treatment processes of acute myocardial infarction in the context of prevention and control of COVID-19 (first edition)]. The control measures to contain the epidemic also produced influences on the transport and treatment process of patients with acute myocardial infarction (AMI), and adjustments in the management of the patients need to be made at this particular time. […] AMI is characterized by an acute onset with potentially fatal consequence, a short optimal treatment window, and frequent complications including respiratory infections and respiratory and circulatory failure, for which active on-site treatment is essential. […] To standardize the management and facilitate the diagnosis and treatment, we formulated the guidelines for the procedures and strategies for the diagnosis and treatment of AMI, which highlight 5 Key Principles, namely Nearby treatment, Safety protection, Priority of thrombolysis, Transport to designated hospitals, and Remote consultation. […] For AMI patients, different treatment strategies are selected based on the screening results of SARS-CoV-2, the time window of STEMI onset, and the vital signs of the patients. […] In the transport and treatment of AMI patients, the physicians should strictly observe the indications for patient transport with appropriate protective measurements of the medical staff. 2020-05-08
[Laboratory testing techniques for SARS-CoV-2]. The selection of appropriate detection techniques and methods for accurate and rapid identification of pathogens therefore plays a key role in improving the diagnosis and treatment of the patients and containing the outbreak. 2020-05-08
[Correlation between clinical classification of COVID-19 and imaging characteristics of MSCT volume scanning of the lungs]. According to the Fifth Edition of the Diagnosis and Treatment Guidelines by the National Health Commission, the patients were divided into common type, severe type and critical type. […] MSCT volume scanning not only allows early diagnosis of COVID-19 but also provides evidence for evaluating the severity of COVID-19 to assist in the clinical treatment of the patients. 2020-05-11
[Diagnosis and treatment of an elderly patient with secondary cerebral infarction caused by COVID-19]. We review the experience with the diagnosis and treatment of secondary cerebral infarction in an elderly patient with coronavirus disease 2019 (COVID-19). […] Early anti-infection therapy, immune regulation and appropriate anticoagulation intervention may help improve the prognosis of the patients. 2020-05-11
[Conducting clinical studies during the epidemics of communicable diseases: perspectives of methodology and health economics]. RCTs provides the gold standard for evaluating the effectiveness of a given treatment for the patients from the outbreaks. 2020-05-11
[Supporting the battle against COVID-19 in E’zhou, Hubei Province: the experience of Guizhou medical team]. Under the instructions by the E’zhou Medical Team Front Command, the staff made quick responses to the surging number of patients with COVID-19 and rapidly formulated treatment plans based on the local conditions. 2020-05-11
[Tracheal intubation in patients with severe and critical COVID-19: analysis of 18 cases]. Twelve patients were still on endotracheal mechanical ventilation in the intensive care unit, and one of them received ECMO treatment due to poor oxygenation. […] For patients with severe and critical COVID-19 and indications of tracheal intubation, we recommend early intubation with invasive respiratory support to improve the treatment efficacy and reduce the mortality. 2020-05-11
Design of potent membrane fusion inhibitors against SARS-CoV-2, an emerging coronavirus with high fusogenic activity. The coronavirus disease COVID-19, caused by emerging SARS-CoV-2, has posed serious threats to global public health, economic and social stabilities, calling for the prompt development of therapeutics and prophylactics. 2020-05-07
Gene of the month: the 2019-nCoV/SARS-CoV-2 novel coronavirus spike protein. The fundamental role of the spike protein in infectivity suggests that it is an important target for vaccine development, blocking therapy with antibodies and diagnostic antigen-based tests. 2020-05-07
Management of Pancreatic Cancer During COVID-19 Pandemic: To Treat or Not to Treat? Pancreatic cancer is a very aggressive disease and survival remains dismal even with treatment. […] Although we have general strategies available from experience in Italy, we need more treatment specific strategies to help mitigate risks of complications and toxicities from chemotherapy in order to protect our patients from COVID-19 as much as possible. 2020-05-13
Immune cell profiling of COVID-19 patients in the recovery stage by single-cell sequencing. Identification of novel BCR signaling may lead to the development of vaccines and antibodies for the treatment of COVID-19. 2020-05-09
First Case of an Infant with COVID-19 in the Middle East. Her RT-PCR test was negative after five days of treatment, suggesting that children can clear the virus faster than adults. […] These findings serve as a practical reference for the clinical diagnosis and medical treatment of children with COVID-19. 2020-05-09
How Essential Is to Focus on Physician’s Health and Burnout in Coronavirus (COVID-19) Pandemic? Although the chief focus is on minimizing transmission through prevention, combating infection, and saving lives by ramping up the development of treatment and vaccines, very little attention is on the critical issue of physician burnout, resident burnout, and the psychological well-being of HCW. 2020-05-09
COVID-19: Review of Epidemiology and Potential Treatments Against 2019 Novel Coronavirus. An expert US committee developed the US NIH guidelines for COVID-19 treatment, which was just released and will be regularly updated. 2020-05-09
Experiencing the Surge: Report from a Large New York Radiation Oncology Department During the COVID-19 Pandemic. This study reviews the impact of COVID-19 on a hospital system in New York on aspects of medicine, nursing, radiation therapy, and administration.Materials/Methods: A retrospective review was conducted of the department of radiation oncology in a single health system in New York from 3/1/20 to 4/1/20. […] Collaboration was obtained from physicians, nursing, radiation therapy, and administration to recall their policies and impact on specific duties. […] Numbers were obtained for patients on treatment, treatments breaks, and COVID-19 infections amongst staff and patients. […] Radiation Oncology made aggressive efforts to reduce patients on treatment to protect patients and staff as well reallocate staff and space for more acute clinical needs. 2020-05-07
Comorbid Chronic Diseases and Acute Organ Injuries Are Strongly Correlated with Disease Severity and Mortality among COVID-19 Patients: A Systemic Review and Meta-Analysis. Moreover, additional clinical data are needed in order to determine whether a supportive therapy can help mitigate the development of severe, potentially fatal complications, and further studies are needed to identify the pathophysiology and the mechanism underlying this novel coronavirus-associated infectious disease. 2020-05-09
COVID-19 in Older People: A Rapid Clinical Review. We searched PubMed and bioRxiv/medRxiv to identify English language papers describing the testing, treatment and prognosis of COVID-19. […] Screening of over 1100 peer-reviewed and pre-print papers yielded n = 22 on COVID-19 testing, n = 15 on treatment and n = 13 on prognosis. 2020-05-29
Early experience of COVID-19 in 2 heart transplant recipients: Case reports and review of treatment options. Despite reduction in immunosuppression and treatment with tocilizumab, intravenous immunoglobulin, hydroxychloroquine, lopinavir/ritonavir, and broad-spectrum antibiotics, she ultimately died from multiorgan failure. 2020-05-22
Application of nanomaterials in treatment, anti-infection and detection of coronaviruses. Application of nanobiotechnology could represent a new avenue for the treatment or disinfection of viruses. 2020-05-07
Animal models for emerging coronavirus: progress and new insights. Current clinical treatment at hand is inadequate to suppress viral replication and inflammation, and reverse organ failure. […] Intensive research efforts have focused on increasing our understanding of viral biology of SARS-CoV-2, improving antiviral therapy and vaccination strategies. […] We will discuss the benefits and caveats of these animal models and present critical findings that might guide the fundamental studies and urgent treatment of SARS-CoV-2-caused diseases. 2020-05-15
Treat 2019 novel coronavirus (COVID-19) with IL-6 inhibitor: Are we already that far? Interleukin 6 (IL-6) inhibitor (tocilizumab) had been suggested for the treatment of acute respiratory distress syndrome (ARDS) patients based on the concept of “cytokine storm” in COVID-19. […] The efficacy of IL-6 monoclonal antibody-directed therapy remains to be fully evaluated. 2020-05-08
COVID-19 - Toward a comprehensive understanding of the disease. More importantly, a compre-hensive understanding of pathological mechanisms of COVID-19 will increase the efficacy of therapy and decrease mortality. 2020-05-29
The Approved Dose of Ivermectin Alone is not the Ideal Dose for the Treatment of COVID-19. Combination therapy should be evaluated in vitro. […] Re-purposing drugs for use in COVID-19 treatment is an ideal strategy but is only feasible when product safety has been established and experiments of re-purposed drugs are conducted at clinically relevant concentrations. 2020-05-07
Comprehensive overview of COVID-19 based on current evidence. In this article, we compared SARS-CoV-2 with SARS-CoV and influenza virus, discussed current researching progress of COVID-19, including clinical characteristics, pathological changes, treatment measures, and so on. 2020-05-22
COVID-19 and toxicity from potential treatments: Panacea or poison. There have already been examples of self-medication and overdose. 2020-05-13
COVID-19: Symptoms, course of illness and use of clinical scoring systems for the first 42 patients admitted to a Norwegian local hospital. A total of nine patients (21 %) had a critical course of illness with treatment in the Intensive Care Department and/or death during their stay in hospital. 2020-05-12
Loss of smell or taste as the only symptom of COVID-19. Together, these findings may inform future research, diagnosis, prevention and treatment of COVID-19. 2020-05-12
Modified management mode for colorectal cancer during COVID-19 outbreak - a single-center experience. We prefer a simple and convenient treatment regimen, which may also be postponed appropriately. […] In total, adequate doctor-patient communication is also recommended throughout the treatment. 2020-05-26
Preventive strategy for the clinical treatment of hip fractures in the elderly during the COVID-19 outbreak: Wuhan’s experience. During this period, our infection and orthopedic treatment unit in the center of the epidemic area effectively treated 82 elderly patients with hip fracture, and no cross-infection occurred. […] Therefore, our experience in prevention and treatment is worth recommending to frontline anti-epidemic personnel. 2020-05-26
Characteristics and Early Prognosis of COVID-19 Infection in Fracture Patients. Analyses of early prognosis were based on clinical outcomes and trends in laboratory results during treatment. […] Surgical treatment should be carried out cautiously or nonoperative care should be chosen for patients with fracture in COVID-19-affected areas, especially older individuals with intertrochanteric fractures. 2020-05-20
A Typical Case of Critically Ill Infant of Coronavirus Disease 2019 With Persistent Reduction of T Lymphocytes. However, our understanding of the clinical characteristics and treatment of critically ill pediatric patients and their ability of transmitting the coronavirus that causes COVID-19 still remains inadequate because only a handful pediatric cases of COVID-19 have been reported. […] Epidemiology, clinical characteristics, treatment, laboratory data and follow-up information and the treatment of critically ill infant were recorded. 2020-05-08
ACE2 Activators for the Treatment of Covid 19 Patients. In the present comment the treatment of COVID19 patients with ACE2 activators, such as diminazene aceturate (DIZE), which are currently used as antiparasitic drugs, is proposed. 2020-05-18
Herbal medicine for treatment of children diagnosed with COVID-19: A review of guidelines. This review aimed to summarize and analyze the pattern identification (PI), herbal formulae, and composition of herbs provided by recent guidelines for the treatment of pediatric COVID-19. […] This review serves as a reference for the use of traditional medicine in the treatment of pediatric COVID-19. 2020-05-11
Effects of progressive muscle relaxation on anxiety and sleep quality in patients with COVID-19. Patients with Coronavirus Disease 2019(COVID-19) will experience high levels of anxiety and low sleep quality due to isolation treatment. […] During this period, the control group received only routine care and treatment. 2020-05-11
Traditional Chinese Medicine treatment of COVID-19. No effective treatment for this disease was verified, so the morbidity and mortality rate were supposed higher than flu. 2020-05-11
Rapid Implementation of an Adult Coronavirus Disease 2019 Unit in a Children’s Hospital. Instead of redeploying pediatric providers to work with internist-led teams throughout a medical center, pediatric physicians and nurses organized and staffed a 40-bed adult COVID-19 treatment unit within a children’s hospital. 2020-05-23
The clinical benefits of Chinese patent medicines against COVID-19 based on current evidence. The outbreak of emerging infectious pneumonia caused by 2019 Novel Coronavirus (2019-nCoV) has posed an enormous threat to public health, and traditional Chinese medicine (TCM) have made vast contribution to the prevention, treatment and rehabilitation of coronavirus disease 19 (COVID-19) among Chinese population. […] Given this, based on the Guideline on Diagnosis and Treatment of Coronavirus Disease 2019 in China, the present review summarized the basic information, clinical evidence and published literatures of recommended CPMs against COVID-19. […] The details were thoroughly introduced involving compositions, therapeutic effects, clinical indications, medication history of CPMs and the profiles of corresponding research. 2020-05-30
In Silico Design of Antiviral Peptides Targeting the Spike Protein of SARS-CoV-2. The antiviral peptides can prevent SARS-CoV-2 membrane fusion and can potentially be used for the prevention and treatment of infections. 2020-05-09
The impacts of viral inactivating methods on quantitative RT-PCR for COVID-19. For the N gene and ORF1ab gene, the CT values of 4 inactivated and Non-inactivated treatment were correlated (P<0.001). […] The results of the four treatment methods and specimens without inactivated treatment have shown good consistency. […] The treatment of nasopharyngeal swab specimens using mentioned four inactivated methods had no significant effect on the subsequent detection of the new COVID-19 nucleic acid test. 2020-05-31
Continuous hydroxychloroquine or colchicine therapy does not prevent infection with SARS-CoV-2: Insights from a large healthcare database analysis. A comparison was conducted between subjects tested positive for SARS-CoV-2 and those found negative in terms of rate of administration of hydroxychloroquine/colchicine therapy. 2020-05-23
What dentists need to know about COVID-19. There has so far been no evidence from randomized controlled trials to prescribe any particular anti-nCoV treatment or vaccine, and COVID-19 management has been widely supportive. 2020-05-20
Endocrinology in the time of COVID-19: Management of Hyponatraemia and Diabetes Insipidus. • The main complication of desmopressin treatment in DI is dilutional hyponatraemia. 2020-05-08
Endocrinology in the time of COVID-19: Management of Cushing’s syndrome. • Clinical evaluation should guide those needing investigation • Strict adherence to COVID-19 protection measures is necessary • Alternative ways of consultations (telephone, video) should be used • Early discussion with regional/national experts about investigation and management of potential and existing patients is strongly encouraged • Patients with moderate and severe clinical features need urgent investigation and management • Patients with active Cushing’s syndrome, especially when severe, are immunocompromised and social shielding is recommended • In patients with mild features or in whom a diagnosis is less likely, clinical re-evaluation should be repeated at three and six months or deferred until the prevalence of SARS-CoV-2 has significantly decreased • Diagnostic pathways may need to be very different from usual recommendations in order to reduce investigations • When extensive differential diagnostic testing is not feasible, it should be deferred, and medical treatment should be initiated • Transsphenoidal pituitary surgery may be avoided during high SARS-CoV-2 viral prevalence • Medical management rather than surgery will be the used for most patients since the short- to mid-term prognosis depends in most cases on hypercortisolism rather than its cause; it should be initiated promptly to minimize the risk of infection in these immunosuppressed patients. 2020-05-08
The pathogenicity of SARS-CoV-2 in hACE2 transgenic mice. The mouse model with SARS-CoV-2 infection will be valuable for evaluating antiviral therapeutics and vaccines as well as understanding the pathogenesis of COVID-19. 2020-05-07
Effects of the COVID-19 Outbreak on Elder Mistreatment and Response in New York City: Initial Lessons. We explore here the impact of this unique crisis on victims of elder mistreatment and people at risk of victimization. […] The COVID-19 outbreak has also had a profound impact on the organizations from many sectors that typically respond to protect and serve victims of elder mistreatment. 2020-05-23
Lack of cross-neutralization by SARS patient sera towards SARS-CoV-2. These findings will be of significant use in guiding the development of serologic tests, formulating convalescent plasma therapy strategies, and assessing the longevity of protective immunity for SARS-related coronaviruses in general as well as vaccine efficacy. 2020-05-11
Exosomes Derived from Bone Marrow Mesenchymal Stem Cells as Treatment for Severe COVID-19. This prospective nonrandomized open-label cohort study addresses the safety and efficacy of exosomes (ExoFlo™) derived from allogeneic bone marrow mesenchymal stem cells as treatment for severe COVID-19. […] Patients received a single 15 mL intravenous dose of ExoFlo and were evaluated for both safety and efficacy from days 1 to 14 post-treatment. […] In total, 17 of 24 (71%) patients recovered, 3 of 24 (13%) patients remained critically ill though stable, and 4 of 24 (16%) patients expired for reasons unrelated to the treatment. […] Overall, after one treatment, patients’ clinical status and oxygenation improved with an average pressure of arterial oxygen to fraction of inspired oxygen ratio (PaO2/FiO2) increase of 192% (P < 0.001). 2020-05-23
A child with household transmitted COVID-19. The chest computed tomography (CT) revealed scattered ground glass opacities in the right lower lobe close to the pleura and resorption after the treatment. 2020-05-12
Confirmation of the high cumulative incidence of thrombotic complications in critically ill ICU patients with COVID-19: An updated analysis. We recently reported a high cumulative incidence of thrombotic complications in critically ill patients with COVID-19 admitted to the intensive care units (ICUs) of three Dutch hospitals. […] In the competing risk model, chronic anticoagulation therapy at admission was associated with a lower risk of the composite outcome (Hazard Ratio [HR] 0.29, 95%CI 0.091-0.92). 2020-05-11
Nosocomial infection with SARS-Cov-2 within Departments of Digestive Surgery. The reasons for hospitalization were: surgical treatment of cancer (n=5), complex emergencies (n=5), treatment of complications linked to cancer or its treatment (n=3), gastroplasty (n=1), and stoma closure (n=1). 2020-05-11
Structural basis for the inhibition of SARS-CoV-2 main protease by antineoplastic drug carmofur. Carmofur inhibits viral replication in cells (EC50 = 24.30 μM) and is a promising lead compound to develop new antiviral treatment for COVID-19. 2020-05-08
Covid-19 and drug therapy, what we learned. Currently, there is still no licensed specific antiviral treatment for the human coronavirus disease and a vaccine will not be ready soon. […] However, based on experience from the use of other antiviral agents to treat similar virusses, some treatment options have been tried with some efficacy. 2020-05-11
COVID-19: a novel coronavirus and a novel challenge for oral healthcare. For the treatment of emergency patients aside from routine epidemic prevention measures, some special measures for oral treatment need to be added. […] From January 23, 2020, to March 2, 2020, a total of 3035 patients received oral therapy during the COVID-19 epidemic in our hospital. […] To our knowledge, no oral health worker or patient has been infected with COVID-19 due to oral treatment, and no patients have complained about the suspension of treatment by complaints hotline. 2020-05-30
Post-exposure prophylaxis or pre-emptive therapy for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2): study protocol for a pragmatic randomized-controlled trial. We describe the design of a clinical trial of hydroxychloroquine for post-exposure prophylaxis (PEP) and pre-emptive therapy (PET) for COVID-19. 2020-05-11
A comparison study of SARS-CoV-2 IgG antibody between male and female COVID-19 patients: A possible reason underlying different outcome between sex. The convalescent plasma containing a high level of SARS-CoV-2 immunoglobulin G (IgG) antibody has been used in clinical therapy and achieved good effects in China. 2020-05-23
Cutaneous manifestations of the Coronavirus Disease 2019 (COVID-19): A brief review. Associated symptoms, latency time, treatment, and prognosis were also carefully summarized. 2020-05-22
Spontaneous coronary artery dissection of the left anterior descending artery in a patient with COVID-19 infection. The patient was subsequently discharged on medical therapy but returned 3 days later due to worsening chest pain. 2020-05-08
Case Report: Right Bundle Brunch Block and QTc Prolongation in a Patient with Novel Coronavirus Disease (COVID-19) Treated with Hydroxychloroquine. Currently, there is no available treatment proven to be effective against COVID-19, but multiple medications, including hydroxychloroquine (HCQ), are used off label. […] We report the case of a 60-year-old woman without any cardiac history who developed right bundle brunch block and critically prolonged corrected electrocardiographic QT interval (QTc 631 ms) after treatment for 3 days with HCQ, which resolved on discontinuation of the medication. 2020-05-08
Cognitive-behavioral therapy in the time of coronavirus: Clinician tips for working with eating disorders via telehealth when face-to-face meetings are not possible. However, many clinicians feel ill equipped to deliver therapy via telehealth, while adhering to evidence-based interventions. […] Seventy clinical colleagues of the authors were emailed and invited to share their concerns online about how to deliver cognitive-behavioral therapy for eating disorders (CBT-ED) via telehealth, and how to adapt clinical practice to deal with the problems that they and others had encountered. 2020-05-08
Controversial Relationship between Renin-Angiotensin System Inhibitors and Severity of COVID-19: Announcing a Large Multicentre Case-Control Study in Italy. The hypothesis has been proposed that patients COVID-19 positive, under anti-hypertensive treatment with angiotensin enzyme inhibitors or angiotensin receptor-blockers, might have a worse or a better clinical prognosis. 2020-05-08
Systems Barriers to Assessment and Treatment of COVID-19 Positive Patients at the End of Life. The Novel Coronavirus SARS-CoV-2 (COVID-19) pandemic is changing how we deliver expert palliative care. […] Isolation of patients, limitation of visitors and interdisciplinary support, and changes in nursing and provider assessment have all had their impact on how we deliver palliative care. 2020-05-08
Prognostic Value of Leukocytosis and Lymphopenia for Coronavirus Disease Severity. Using these markers for early identification of patients with severe disease may help healthcare providers prioritize the need to obtain therapy. 2020-05-08
In-hospital management of persons with haemophilia and COVID-19: practical guidance. Rapid identification of the haemophilia status, undelayed and regular liaison with the haemophilia team, proper therapy with factor concentrates or alternative treatments appear instrumental to prevent haemophilia-related complications in this setting. 2020-05-08
COVID-19 ventilatory phenotypes and obesity: is there a relationship? Although data are scarce at this stage, there is also an unexplained increased prevalence of obesity in patients infected with SARS-CoV-2 admitted to the intensive care units (ICU) (2). 2020-05-08
Novel coronavirus 2019 (COVID-19): A case report and review of treatments. While several companies have already begun vaccine trials and healthcare facilities have been using a wide-range of medications to treat the virus and symptoms, there is not yet an approved medication regimen for COVID-19 infections. 2020-05-13
Potential Cytoprotective Activity of Ozone Therapy in SARS-CoV-2/COVID-19. Systemic ozone therapy (OT) could be potentially useful in the clinical management of several complications secondary to SARS-CoV-2. 2020-05-11
COVID-19 and ECMO: the interplay between coagulation and inflammation-a narrative review. Veno-venous extracorporeal membrane oxygenation (V-V ECMO) may serve as life-saving rescue therapy for refractory respiratory failure in the setting of acute respiratory compromise such as that induced by SARS-CoV-2. 2020-05-13
Consensus for prevention and management of coronavirus disease 2019 (COVID-19) for neurologists. Therefore, patients with nervous system involvement as the presenting symptoms in the early stage of infection may easily be misdiagnosed and their treatment delayed. 2020-05-14
Training in neurology: Flexibility and adaptability of a neurology training program at the epicenter of COVID-19. Many of these changes unfolded over days, including removing residents from outpatient services, minimizing the number of residents on inpatient services, deploying residents to medicine services and medical intensive care units, converting continuity clinic patient visits to virtual options, transforming didactics to online platforms only, and maintaining connectedness in an era of social distancing. 2020-05-29
Current State of Knowledge About SARS-CoV-2 and COVID-19 Disease in Pregnant Women. With regard to the management of pregnant COVID-19 patients, in addition to the treatment of the infection itself, which is not that different from generally accepted principles, it is interesting to consider which obstetric procedures should be used to minimize the adverse effects on mother and child. 2020-05-12
What will be the new normal for the dental industry? To facilitate any move towards the resumption of widespread dental treatment, possibly without mass vaccination or the widespread use of antibody testing, the aerosol issue will need to be addressed and solved. 2020-05-13
Systematic review of the prevalence of current smoking among hospitalized COVID-19 patients in China: could nicotine be a therapeutic option? Although the generalized advice to quit smoking as a measure to reduce health risk remains valid, the findings, together with the well-established immunomodulatory effects of nicotine, suggest that pharmaceutical nicotine should be considered as a potential treatment option in COVID-19. 2020-05-14
COVID-19 and Cancer: a Comprehensive Review. In this comprehensive review, we discuss the impact of COVID-19 on health and the immune system of those affected, reviewing the latest treatment approaches and ongoing clinical trials. 2020-05-12
Inflammation resolution: a dual-pronged approach to averting cytokine storms in COVID-19? SPMs also promote anti-viral B cell antibodies and lymphocyte activity, highlighting their potential use in the treatment of COVID-19. 2020-05-14
COVID-19 and off label use of drugs: an ethical viewpoint. There is no proven medication for its treatment, so, all of the medications used for treatment are considered to be off-label. 2020-05-14
COVID-19 pulmonary infection in erythrodermic psoriatic patient with oligodendroglioma: safety and compatibility of apremilast with critical intensive care management. Psoriasis treatment relies on immunosuppression, and although most experts agree that the benefit-to risk-ratio is in favor of maintaining selective biologic therapies, and small molecules such as apremilast, they recommend dismission if severe COVID-19 symptoms occur. 2020-05-09
Systemic Immunobiological, Immunosuppressant and Oncologic Agents for the Treatment of Dermatologic Diseases during the SARS-Cov-2 (COVID19) Pandemic Emergency: a Quick Review for a Quick Consultation. In this quick review we have analyzed the mechanisms of action and related infective risk of drugs used for the treatment of immune-mediated and oncologic skin conditions during the daily clinical practice. […] In the case of a COVID19 patient with complication (such as pneumonia, respiratory failure), treatment suspension should always be considered after taking into account the general condition of the patient, the risk-benefit ratio and the pathophysiology of COVID19 infection. […] The COVID19 emergency pandemic does not imply an under-treatment of existing skin conditions, which together with the SARS-Cov2 infection may jeopardize the patient’s life. 2020-05-09
[Materialism and dialectics of epidemic prevention and control: only by respecting science can we do more with less]. Many phenomena and problems in the work of epidemic prevention, control and treatment are worthy of our deep reflection. 2020-05-12
[Chinese experts’ consensus on diagnosis and treatment of severe and critical coronavirus disease 2019 (revised edition)]. The outbreak of coronavirus disease 2019 (COVID-19) is serious and there is no effective treatment to date. […] In order to reduce the mortality of severe and critical COVID-19, experts from the first-line in related fields in China were organized to analyze, discuss and summarize the diagnosis and treatment of severe and critical COVID-19 patients in Wuhan and other severe epidemic areas, and formulate the expert consensus. 2020-05-12
[Visualization analysis on treatment of coronavirus based on knowledge graph]. To discuss the research progress in the field of coronavirus (CoVs) treatment based on the visualization analysis of knowledge graph. […] The related literatures in the field of CoVs treatment were retrieved from the establishment of Web of Science core collection database to February 15th, 2020, and the literature analysis tool of Web of Science database was used to count the annual trend of published literatures. […] In terms of literature volume, the literatures on CoVs therapy rose after 2003 and 2012, and the number of published literatures had remained high since 2014. […] In terms of countries, the main countries that carried out the research on the treatment of CoVs were the United States (n = 613), China (n = 582), Germany (n = 122), Canada (n = 99), etc., and the cooperation among countries was close. […] In terms of institutions, the number of papers issued by Chinese Academy of Sciences in the field of CoVs treatment ranked first (n = 82), followed by University of Hong Kong of China (n = 74) and Chinese University of Hong Kong of China (n = 58), followed by National Institute of Allergy and Infectious Diseases (n = 37), and the cooperation among various institutions was close. […] The treatment hot spots focused on preventing virus adsorption, inhibiting the virus gene nucleic acid replication, transcription and translation. […] Through the visualization analysis of knowledge graph, the development trend and hot spots of CoVs therapy research could be well observed. […] In this study, the degree of attention in the field of CoVs treatment showed periodic changes, related to the outbreak of new CoVs, and the country, institutions and the author were closely related. […] The treatment hot spots focused on preventing virus adsorption, inhibiting the virus gene nucleic acid replication, transcription and translation in order to develop new targets of drug. 2020-05-12
Imaging examination, diagnosis, and control and prevention of nosocomial infection for coronavirus disease 2019: Expert consensus of Hunan radiologist. There is no specific treatment so far. 2020-05-13
Chest CT findings and clinical features of coronavirus disease 2019 in children. All patients had absorbed lesions on follow-up CT images after treatment. 2020-05-13
Multistage CT features of coronavirus disease 2019. To determine imaging features of coronavirus disease 2019 (COVID-19) in different stages, and to provide foundations for early diagnosis and treatment. 2020-05-13
Value of CT application in the screening,diagnosis,and treatment of COVID-19. Early screening, early diagnosis, early isolation, and early treatment remain the most effective prevention and control measures. […] Computed tomography (CT) plays a vital role in the screening, diagnosis, treatment, and follow-up of COVID-19, especially in the early screening, with a higher sensitivity than that of real-time fluorescence RT-PCR. 2020-05-13
Unprecedented action has been taken to contain the epidemic of coronavirus disease 2019 in China. Significant improvement regarding the pathogenesis, epidemiology, and diagnosis and therapy for the COVID-19 has been achieved to stop the spread of the epidemics. 2020-05-13
Capturing patient-reported outcomes during the COVID-19 pandemic: Development of the COVID-19 Global Rheumatology Alliance Patient Experience Survey. The C19-GRA launched an international, secure, de-identified physician registry of patients with rheumatic diseases infected with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) to provide insights into the management and treatment of COVID-19 in this population. 2020-05-09
SARS-CoV-2 asymptomatic infection in a patient under treatment with dupilumab. We have read with great interest the letter of the European Task Force on Atopic Dermatitis (ETFAD) on SARS-CoV-2-infection and atopic dermatitis published in JEADV (March 2020)1 in which the authors state: “Targeted treatment selectively interfering with type-2 inflammation such as dupilumab is not considered to increase the risk for viral infections and might thus be preferred …in a situation such as COVID-19 pandemic”.1. 2020-05-09
Pregnant and postpartum women with SARS-CoV-2 infection in intensive care in Sweden. The Public Health Agency of Sweden has analysed how many pregnant and postpartum women with SARS-CoV-2 infection have been treated in intensive care units (ICU) in Sweden between the March 19 and April 20, 2020, compared with non-pregnant women of similar age. 2020-05-09
Acute Generalized Exanthematous Pustulosis with Erythema Multiforme-Like lesions in a COVID-19 woman. The antimalarials, Chloroquine and Hydroxychloroquine (HCQ), and the antivirals Lopinavir/Ritonavir have been recently recorded as having anti-severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) effects.1 In particular, regarding Italy, one of the countries most affected by the pandemic, the Italian Society of Infectious and Tropical disease (Lombardy section) has recommended the use of HCQ for treatment of coronavirus disease 2019 (COVID-19). 2020-05-09
Chilblains in children in the setting of COVID-19 pandemic. It is a mildly symptomatic condition with an excellent prognosis, usually requiring no therapy. 2020-05-23
Interventions for treatment of COVID-19: a protocol for a living systematic review with network meta-analysis including individual patient data (The LIVING Project). No intervention has yet been proven effective for the treatment of COVID-19. […] We will include randomized clinical trials comparing any intervention for the treatment of COVID-19 (e.g., pharmacological interventions, fluid therapy, invasive or noninvasive ventilation, or similar interventions) with any comparator (e.g., an “active” comparator, standard care, placebo, no intervention, or “active placebo”) for participants in all age groups with a diagnosis of COVID-19. […] Secondary outcomes will be admission to intensive care, mechanical ventilation, renal replacement therapy, quality of life, and non-serious adverse events. […] This review will continuously inform best practice in treatment and clinical research of this highly prevalent disease. 2020-05-13
Bariatric and metabolic surgery during and after the COVID-19 pandemic: DSS recommendations for management of surgical candidates and postoperative patients and prioritisation of access to surgery. Hence, surgical candidates face prolonged delays of beneficial treatment. 2020-05-29
Surgeons, plague, and leadership: A historical mantle to carry forward. We as a surgical community should herald their examples and re-focus our efforts to pioneer investigations into the coronavirus, helping elucidate the biology, understand its social effects, and provide effective treatment regimens for the disease. 2020-05-14
Impact of COVID-19 related healthcare crisis on treatments for patients with lysosomal storage disorders, the first Italian experience. The direct and indirect effects of Coronavirus Disease-19 (COVID-19) pandemic, on Italian patients with lysosomal storage disorders receiving therapy, were analyzed by a phone questionnaire. […] Forty-nine% of patients receiving enzyme replacement therapy in hospitals experienced disruptions, versus 6% of those home-treated. 2020-05-14
Managing Cancer Care during the COVID-19 Pandemic and Beyond. Cancer therapy is complex, and outcomes are centered on timing. 2020-05-14
Anti-cancer therapy and clinical trial considerations for gynecologic oncology patients during the COVID-19 pandemic crisis. Highly immunosuppressive chemotherapy regimens and possible exposure to COVID-19 during treatment may put patients at additional risk. […] An expert panel convened to develop initial consensus guidelines regarding anti-neoplastic therapy during the COVID-19 pandemic with respect to gynecologic cancer care and clinical trials. 2020-05-14
[Repurposing of chlorpromazine in COVID-19 treatment: the reCoVery study]. Chlorpromazine (CPZ) is a phenothiazine derivative widely used in clinical routine in the treatment of acute and chronic psychoses. […] This first antipsychotic medication has been discovered in 1952 by Jean Delay and Pierre Deniker at Sainte-Anne hospital. […] The main objective is to demonstrate a shorter time to response (TTR) to treatment in the CPZ+standard-of-care (CPZ+SOC) group, compared to the SOC group. […] Response to treatment is defined by a reduction of at least one level of severity on the WHO-Ordinal Scale for Clinical Improvement (WHO-OSCI). […] CRP and lymphopenia); (D) a greater decrease in parenchymal involvement (chest CT) on the seventh day post-randomization; (E) to define the optimal dosage of CPZ and its tolerance; (F) to evaluate the biological parameters of response to treatment, in particular the involvement of inflammatory cytokines. […] This CPZ repositioning strategy also avoids numerous developmental and experimental steps and can save precious time to rapidly establish an anti-COVID-19 therapy with well-known, limited and easy to manage side effects. […] The broad spectrum of CPZ treatment - including antipsychotic, anxiolytic, antiemetic, antiviral, immunomodulatory effects along with inhibition of clathrin-mediated endocytosis and modulation of blood-brain barrier - is in line with the historical French commercial name for CPZ, i.e. 2020-05-14
Sofosbuvir as Repurposed Antiviral Drug Against COVID-19: Why Were We Convinced to Evaluate the Drug in a Registered/Approved Clinical Trial? Sofosbuvir active metabolite, however, shows an extremely high intracellular stability So, it is hypothesized that SARS-CoV-2 infection could also be susceptible to sofosbuvir and we were convinced to design and run a clinical trial to evaluate the effect of sofosbuvir 400 mg (in combination with velpatasvir 100 mg, as add-on treatment, in addition to standard of care) on the COVID-19. 2020-05-17
COVID-19 and Moral Imperialism in Multinational Clinical Research. This case highlights a problematic ethical double standard in multinational clinical research: trials that would be considered unethical in high income countries (e.g., placebo-controlled where there is an existing treatment) are nonetheless justified in low-and-middle-income countries because the existing standards of care are less (i.e., no access to a treatment). 2020-05-14
Treatment of primary and metastatic peritoneal tumors in the Covid-19 pandemic. Proposals for prioritization from the RENAPE and BIG-RENAPE groups. This is particularly so for peritoneal neoplastic diseases, for which curative treatment mobilizes substantial personnel, operating room and intensive care resources. […] It is desirable to prioritize disease conditions for which cytoreduction surgery with or without associated hyperthermic intraoperative peritoneal chemotherapy (HIPEC) is the gold-standard treatment, and for which systemic chemotherapy cannot be a temporary or long-term alternative: pseudomyxoma peritonei, resectable malignant peritoneal mesotheliomas, peritoneal metastases of colorectal origin if they are resectable and unresponsive to systemic chemotherapy after up to 12 courses, first-line ovarian carcinomatosis if resectable or in interval surgery after at most six courses of systemic chemotherapy. 2020-05-22
COVID-19 and acute lymphoblastic leukemias of children and adolescents: First recommendations of the Leukemia committee of the French Society for the fight against Cancers and Leukemias in children and adolescents (SFCE). However, the very nature of acute lymphoblastic leukemias and their treatment in children and adolescents led the Leukemia Committee of the French Society for the fight against cancers and leukemias in children and adolescents (SFCE) to propose more specific recommendations, even if data for this population are still scarce. 2020-05-24
A Dual-Center Observational Review of Hospital-Based Palliative Care in Patients Dying With COVID-19. The current coronavirus disease 2019 (COVID-19) pandemic has put significant strain on all aspects of health care delivery, including palliative care services. 2020-05-26
When fear and misinformation go viral: Pharmacists’ role in deterring medication misinformation during the ‘infodemic’ surrounding COVID-19. Amid the growing burden of the pandemic, there are parallel emergencies that need to be simultaneously tackled: the proliferation of fake medicines, fake news and medication misinformation surrounding COVID-19. […] Primarily, they can be a relevant source of accurate and reliable information to the public or other fellow health professionals thereby reducing the spread of COVID-19 medication misinformation. 2020-05-29
Recognizing COVID-19-related myocarditis: the possible pathophysiology and proposed guideline for diagnosis and management. Where the diagnosis remains uncertain, an endomyocardial biopsy may help identify active cardiac infection through viral genome amplification and possibly refine the treatment risks of systemic immunosuppression. 2020-05-14
ENHANCED ECG MONITORING OF COVID-19 PATIENTS. Many of the drugs being used in the treatment of the ongoing pandemic coronavirus disease 2019 (COVID-19) are associated with QT prolongation. 2020-05-14
The CoV-2 outbreak: how hematologists could help to fight Covid-19. A possible combined treatment algorithm for COVID-19 is here proposed. 2020-05-30
Tocilizumab therapy reduced intensive care unit admissions and/or mortality in COVID-19 patients. No therapy has yet proven effective in COVID-19. […] Tocilizumab (TCZ) in patients with severe COVID-19 could be an effective treatment. […] Patients with TCZ (n=20) had a higher Charlson comorbidity index (5.3 [±2.4] vs 3.4 [±2.6], P=0.014), presented with more severe forms (higher level of oxygen therapy at 13L/min vs 6L/min, P<0.001), and had poorer biological findings (severe lymphopenia: 676/mm3 vs 914/mm3, P=0.037 and higher CRP level: 158mg/L vs 105mg/L, P=0.017) than patients without TCZ (n=25). 2020-05-17
Current development of COVID-19 diagnostics, vaccines and therapeutics. In this review, we describe some currently applied diagnostic approaches, as well as therapeutics and vaccines, to prevent, treat and control further outbreaks of SARS-CoV-2 infection. 2020-05-16
Early treatment of COVID-19 patients with hydroxychloroquine and azithromycin: A retrospective analysis of 1061 cases in Marseille, France. In France, the combination hydroxychloroquine (HCQ) and azithromycin (AZ) is used in the treatment of COVID-19. 2020-05-16
Androgen-deprivation therapies for prostate cancer and risk of infection by SARS-CoV-2: a population-based study (n=4532). The parameters used for each COVID-19 positive patient were gender, hospitalization, admission to intensive care unit (ICU), death, tumor diagnosis, prostate cancer diagnosis, and androgen-deprivation therapy (ADT). 2020-05-14
Caring for Bereaved Family Members During the COVID-19 Pandemic: Before and After the Death of a Patient. Bereavement care is considered an integral component of quality end-of-life care endorsed by the palliative care movement. […] In this article, drawing on the palliative care and bereavement literature, we offer suggestions about how to incorporate palliative care tools and psychological strategies into bereavement care for families during this pandemic. 2020-05-30
Availability of Internationally Controlled Essential Medicines in the COVID-19 Pandemic. These medicines, essential to palliative care, are regulated under the international drug control conventions overseen by United Nations (UN) specialized agencies and treaty bodies and under national drug control laws. […] This paper describes the issues related to the lack of availability and limited access to ICEMs during the COVID-19 pandemic in both intensive and palliative care patients in countries of all income levels and makes recommendations for improving access. 2020-05-14
Therapeutic use of chloroquine and hydroxychloroquine in COVID-19 and other viral infections: A narrative review. While approved specific antiviral drugs against SARS-CoV-2 are still lacking, a large number of existing drugs are being explored as a possible treatment for COVID-19 infected patients. […] In an attempt to explore the evidence that supports their use in COVID-19 patients, we comprehensively reviewed the previous studies which used CQ or HCQ as an antiviral treatment. […] Given the current uncertainty, it is worth being mindful of the potential risks and strictly rationalise the use of these drugs in COVID-19 patients until further high quality randomized clinical trials are available to clarify their role in the treatment or prevention of COVID-19. 2020-05-22
First confirmed detection of SARS-CoV-2 in untreated wastewater in Australia: A proof of concept for the wastewater surveillance of COVID-19 in the community. In the current work, SARS-CoV-2 RNA was concentrated from wastewater in a catchment in Australia and viral RNA copies were enumerated using reverse transcriptase quantitative polymerase chain reaction (RT-qPCR) resulting in two positive detections within a six day period from the same wastewater treatment plant (WWTP). 2020-05-19
Interactions between antihyperglycemic drugs and the renin-angiotensin system: Putative roles in COVID-19. A mini-review. Early insulin therapy seems very promising in alleviating lung injury. 2020-05-27
COVID-19 and diabetes mellitus: An unholy interaction of two pandemics. On the contrary, direct β-cell damage, cytokine-induced insulin resistance, hypokalemia and drugs used in the treatment of COVID-19 (like corticosteroids, lopinavir/ritonavir) can contribute to worsening of glucose control in people with diabetes mellitus. 2020-05-27
Internet of things (IoT) applications to fight against COVID-19 pandemic. IoT implementation impacts on reducing healthcare cost and improve treatment outcome of the infected patient. […] IoT is helpful for an infected patient of COVID-19 to identify symptoms and provides better treatment rapidly. 2020-05-27
COVID-19 occurring during Natalizumab treatment: a case report in a patient with extended interval dosing approach. Development of PML or other serious opportunistic infections during treatment with natalizumab forces to consider whether de-risking strategies are needed in this particular context and how to manage a high-efficacy treatment. […] This case supports the opportunity to avoid discontinuing or delaying the retreatment over 8 weeks in patients recovered from a recent COVID-19. 2020-05-27
Adamantanes might be protective from COVID-19 in patients with neurological diseases: multiple sclerosis, parkinsonism and cognitive impairment. They were receiving treatment with either amantadine (n=15) or memantine (n=7) in stable registered doses. 2020-05-26
Light as a potential treatment for pandemic coronavirus infections: A perspective. The evidence shows that violet/blue (400-470 nm) light is antimicrobial against numerous bacteria, and that it accounts for Niels Ryberg Finsen’s Nobel-winning treatment of tuberculosis. 2020-05-27
Low-dose radiation therapy for COVID-19 pneumopathy: what is the evidence? Due to the current lack of effective pharmacological concepts, this situation has caused interest in (re)considering historical reports on the treatment of patients with low-dose radiation therapy for pneumonia. […] Although these historical reports are of low-level evidence per se, hampering recommendations for decision-making in the clinical setting, they indicate effectiveness in the dose range between 0.3 and 1 Gy, similar to more recent dose concepts in the treatment of acute and chronic inflammatory/degenerative benign diseases with, e.g., a single dose per fraction of 0.5 Gy. […] This concise review aims to critically review the evidence for low-dose radiation treatment of COVID-19 pneumopathy and discuss whether it is worth investigating in the present clinical situation. 2020-05-14
Guillain-Barré syndrome during SARS-CoV-2 pandemic: A case report and review of recent literature. The neurological symptoms improved significantly during treatment with immunoglobulins. 2020-05-26
[Real-world efficacy and safety of lopinavir/ritonavir and arbidol in treating with COVID-19 : an observational cohort study]. Objective: To evaluate the efficacy and safety of lopinavir/ritonavir (LPV/r) and arbidol in the treatment of COVID-19 in the real world. Methods: The clinical data of 178 patients diagnosed with COVID-19 admitted to Guangzhou Eighth People’s Hospital were retrospectively analyzed from January 21 to February 9, 2020. […] According to the patient’s antiviral treatment regimen, 178 patients were divided into 4 groups including LPV/r group (59 patients), arbidol group (36 patients), combination therapy with LPV/r plus arbidol group (25 patients) and the conventional treatment group without any antiviral drugs (58 patients). […] The main observation end points of the study was the negative conversion time of nucleic acid of the novel coronavirus (2019-nCoV) in pharyngeal swab. Results: The baseline of 4 groups before treatment was consistent and comparable. […] The negative conversion time of nucleic acid of the 2019-nCoV in pharyngeal swab was (10.20 ± 3.49), (10.11 ± 4.68), (10.86 ± 4.74), (8.44 ± 3.51) days separately in the LPV/r group, the arbidol group, the combination therapy group, and the conventional treatment group without significant difference (F = 2.556, P = 0.058). […] However, a statistically significant difference was found in the proportion of deterioration changing from mild/moderate to severe/critical type at day 7 (χ(2) = 9.311, P = 0.017) as follows: the combination therapy group (24.0%, 6/25), the arbidol group ( 16.7%, 6/36), LPV/r group (5.4%, 3/56) and conventional treatment group (5.2%, 3/58). […] Moreover, the frequency of adverse reactions in the three groups receiving antiviral drugs was significantly higher than that in the conventional treatment group (χ(2) = 14.875, P = 0.002). Conclusions: No evidences could prove that LPV/r and arbidol could shorten the negative conversion time of novel coronavirus nucleic acid in pharyngeal swab nor improve the symptoms of patients. […] Noteworthy, the adverse reactions of the antiviral drugs should be paid careful attention during the treatment. 目的: 评价真实世界中洛匹那韦/利托那韦(LPV/r)及阿比多尔治疗新型冠状病毒肺炎(COVID-19)的疗效和安全性。 2020-05-10
[Analysis of the first cluster of cases in a family of COVID-19 in Gansu Province]. Among the 7 patients, 1 case died of (B) aggravation, and the other patients’ condition was effectively controlled after active treatment. 2020-05-12
Emergency Authorization of Chloroquine and Hydroxychloroquine for Treatment of COVID-19. Because of its higher potency and better safety profile, hydroxychloroquine may be the more reasonable treatment option if treatment is initiated. 2020-05-21
Clinical Guidance for the Management of Patients with Urothelial Cancers During the COVID-19 Pandemic - Rapid Review. In addition, staff illness and restructuring of services to deal with the crisis will inevitably place treatment capacities under significant strain. 2020-05-13
[Recommendations of the Urolithiasis Committee of the French Urology Association for the management and the treatment of the stone formers patients during the COVID-19 pandemic crisis]. For the first time, faced with a crisis with an exceptional magnitude due to the COVID-19 pandemic responsible for saturation of emergency services and intensive care units, the urolithiasis committee of the French Urology Association designed the recommendations for care and treatment of stone-forming patients and their treatment during crisis. 2020-05-14
SARS-CoV-2 infection in patients on renal replacement therapy. Report of the COVID-19 Registry of the Spanish Society of Nephrology (SEN). Patients on renal replacement therapy (RRT) have not been unaware of this situation and due to their characteristics they are especially vulnerable. […] A very high percentage (85%) required hospital admission, 8% in intensive care units. 2020-05-14
Surgical tracheostomies in COVID-19 patients: A multidisciplinary approach and lessons learned. Surgical tracheostomies have a role in the weaning process of COVID-19 patients treated in intensive care units. 2020-05-15
An infant with a mild SARS-CoV-2 infection detected only by anal swabs: a case report. She was given atomization inhalation therapy with recombinant human interferon alfa-1b for 10 days. 2020-05-17
Pharmacy Emergency Preparedness and Response (PEPR): a proposed framework for expanding pharmacy professionals’ roles and contributions to emergency preparedness and response during the COVID-19 pandemic and beyond. Pharmacists have long been involved in public health and emergency preparedness and response (EP&R), including through preventive measures such as screening, vaccinations, testing, medical and pharmaceutical countermeasures, as well as ensuring medication safety and access during natural disasters and pandemics. 2020-05-15
JAACAP’s Role in Advancing the Science of Pediatric Mental Health and Promoting the Care of Youth and Families During the COVID-19 Pandemic. The pandemic is exposing, with terrible clarity, the disparities in human society-racism,6 poverty,7,8 domestic violence,9,10 and child maltreatment and neglect11-and tragically will likely amplify the negative impacts that each has on child development and mental health. 2020-05-30
Plasmapheresis treatment in COVID-19-related autoimmune meningoencephalitis: Case series. In this paper, we report the results of plasmapheresis treatment in a series of severely ill patients with COVID-19-related autoimmune meningoencephalitis in the Intensive Care Unit (ICU). 2020-05-18
Advocacy to provide good quality oncology services during the COVID-19 pandemic - Actions at 3-levels. In addition to making practice changes to cope with the adverse realities, oncologists should also work together to raise pragmatic suggestions to policy makers and be strong advocates to protect our patients from the detrimental effect of delay or compromised treatment. 2020-05-31
Brief recommendations on the management of adult patients with familial hypercholesterolemia during the COVID-19 pandemic. We discuss the implications of COVID-19 infections for FH patients, the importance of continuing lipid-lowering therapy where possible, issues relating to safety monitoring and service delivery. 2020-05-31
An international comparison analysis of reserve and supply system for emergency medical supplies between China, the United States, Australia, and Canada. With the explosive growth of confirmed cases, emergency medical supplies are facing global shortage, which restricts the treatment of seriously ill patients and protection of medical staff. 2020-05-11
Clinical Features and Outcomes of 98 Patients Hospitalized with SARS-CoV-2 Infection in Daegu, South Korea: A Brief Descriptive Study. All patients received antibiotic therapy, and most (97/98 patients; 99.0%) received antiviral therapy (lopinavir/ritonavir). […] Hydroxychloroquine was used in 79 patients (80.6%), and glucocorticoid therapy was used in 18 patients (18.4%). 2020-05-12
The Current and Future State of Vaccines, Antivirals and Gene Therapies Against Emerging Coronaviruses. We will discuss the potential of AAV-based gene therapy technology for in vivo therapeutic antibody delivery to combat SARS-CoV-2 outbreak and the future emergence of severe CoVs. 2020-05-15
Is the use of RAS inhibitors safe in the current era of COVID-19 pandemic? During infection and its complication such as sepsis, hypotension could be exacerbated by antihypertensive drugs because homeostasis mechanisms such as sodium balance, renin angiotensin aldosterone system and/or sympathetic nervous system can be mitigated by antihypertensive drug therapy. 2020-05-15
A Hemodialysis Patient with Severe COVID-19 Pneumonia. We describe the clinical presentation of this patient, the diagnostic process, the laboratory and imaging investigations, as well as the course of treatment. 2020-05-15
A Precision Medicine Approach to SARS-CoV-2 Pandemic Management. Precision medicine (PM) represents a new paradigm in disease diagnosis, prevention, and treatment. […] Better understanding of pathogenic pathways together with an accurate phenotype classification of patients presented with SARS-CoV-2 infection and symptoms might contribute to a more accurate definition of biomarkers and other diagnostic tools, which may lead to more precise mitigation strategies, personalized pharmacologic options, as well as new biological therapy developments. 2020-05-15
Results of Multilevel Containment Measures to Better Protect Lung Cancer Patients From COVID-19: The IEO Model. In this historical moment, medical oncologists are required to consider the possibility to delay active treatment administration based on a case-by-case risk/benefit evaluation. […] Potential risks associated with COVID-19 infection should be considered, considering tumor histology and natural course, disease setting, clinical conditions, and disease burden, together with the expected benefit, toxicities (e.g., myelosuppression or interstitial lung disease), and response obtained from the planned or ongoing treatment. […] Proactive management and containment measures, applied in a structured and daily way, has significantly aided the identification of advance patients with suspected symptoms related to COVID-19, limiting their admission to our cancer center; we have thus been more able to protect other patients from possible contamination and at the same time guarantee to the suspected patients the immediate treatment and evaluation in referral hospitals for COVID-19. 2020-05-15
COVID-19 Trend Estimation in the Elderly Italian Region of Sardinia. Furthermore, given that a relevant proportion of infected people need hospitalization in Intensive Care Units, this may be a crucial issue for National Healthcare System’s capacity. 2020-05-15
Use of Corticosteroids in Coronavirus Disease 2019 Pneumonia: A Systematic Review of the Literature. The aim was to investigate the effectiveness of glucocorticoid therapy in patients with COVID-19. 2020-05-15
Clinical course of severe and critical COVID-19 in hospitalized pregnancies: a US cohort study. Treatment and neonatal outcomes are also reported. 2020-05-11
[Diagnosis and treatment recommendation for pediatric COVID-19 (the second edition)]. Early identification, early isolation, early diagnosis and early treatment are important for clinical management. […] The treatment of mild or moderate type of child COVID-19 is mainly symptomatic. […] For severe and critical ill cases, the oxygen therapy, antiviral drugs, antibacterial drugs, glucocorticoids, mechanical ventilation or even extracorporeal membrane oxygenation (ECMO) may be adopted, and the treatment plan should be adjusted timely through multi-disciplinary cooperation. 2020-05-12
[Management of COVID-19: the Zhejiang experience]. Based on the present expert consensus carried out by National Health Commission and National Administration of Traditional Chinese Medicine, our team summarized and established an effective treatment strategy centered on “Four-Anti and Two-Balance” for clinical practice. […] Meanwhile, integrated multidisciplinary personalized treatment was recommended to improve therapeutic effect. […] Early antiviral treatment could alleviate disease severity and prevent illness progression, and we found lopinavir/ritonavir combined with abidol showed antiviral effects in COVID-19. […] The artificial liver blood purification system could rapidly remove inflammatory mediators and block cytokine storm.Moreover, it also favored the balance of fluid, electrolyte and acid-base and thus improved treatment efficacy in critical illness. […] Conservative oxygen therapy was preferred and noninvasive ventilation was not recommended. […] We also integrated Chinese medicine in treatment to promote disease rehabilitation through classification methods of traditional Chinese medicine. […] However, since COVID-19 was a newly emerging disease, more work was warranted to improve strategies of prevention, diagnosis and treatment for COVID-19. 2020-05-12
[Pharmaceutical care for severe and critically ill patients with COVID-19]. Severe and critically ill patients with coronavirus disease 2019 (COVID-19) were usually with underlying diseases, which led to the problems of complicated drug use, potential drug-drug interactions and medication errors in special patients. […] Based on Diagnosis and treatment of novel coronavirus pneumonia (trial version 6), and Management of COVID-19: the Zhejiang experience, we summarized the experience in the use of antiviral drugs, corticosteroids, vascular active drugs, antibacterial, probiotics, nutrition support schemes in severe and critically ill COVID-19 patients. […] It is also suggested to focus on medication management for evaluation of drug efficacy and duration of treatment, prevention and treatment of adverse drug reactions, identification of potential drug-drug interactions, individualized medication monitoring based on biosafety protection, and medication administration for special patients. 2020-05-12
[Study on the epidemic development of COVID-19 in Hubei province by a modified SEIR model]. By using Euler integral algorithm to solve the modified SEIR dynamics model, the epidemic situation in Hubei province was analyzed, and the impact of prevention and control measures such as quarantine and centralized treatment on the epidemic development was discussed. […] Theoretical analysis showed that prevention and control quarantine and medical follow-up quarantine played an important inhibitory effect on the outbreak of the epidemic.The centralized treatment played a key role in the rapid decline in the number of infected people. 2020-05-12
[Dynamic changes of chest CT imaging in patients with COVID-19]. The chest CT images of patients with COVID-19 have certain characteristics with dynamic changes, which are of value for monitoring disease progress and clinical treatment. 2020-05-12
[CT imaging features of patients with different clinical types of COVID-19]. A total of 67 patients diagnosed as COVID-19 by nucleic acid testing were collected and divided into 4 groups according to the clinical stages based on Diagnosis and treatment of novel coronavirus pneumonia (trial version 6). 2020-05-12
[Clinical analysis of suspected COVID-19 patients with anxiety and depression]. During the isolation treatment of suspected COVID-19 patients, early psychological intervention should be carried out for the female patients with known contact history of epidemic area and personnel in epidemic area, and drug treatment should be given in advance if necessary. 2020-05-12
[Roles of multidisciplinary team in diagnosis and treatment of suspected cases of COVID-19]. To analyze the roles of multidisciplinary team (MDT) in the diagnosis and treatment of suspected cases of coronavirus disease 2019 (COVID-19). […] With the guidance of MDT, one COVID-19 patient was transferred to designated provincial hospital after effective treatment; one patient complicated with acute cholecystitis underwent gallbladder puncture and drainage; and COVID-19 was excluded in a highly suspected patient after alveolar lavage fluid examination. […] The efficiency of diagnosis and treatment for suspected COVID-19 patients can be improved with MDT, particularly for complicated cases. 2020-05-12
[A pilot study of hydroxychloroquine in treatment of patients with moderate COVID-19]. To evaluate the efficacy and safety of hydroxychloroquine (HCQ) in the treatment of patients with moderate coronavirus disease 2019 (COVID-19). […] We prospectively enrolled 30 treatment-naïve patients with confirmed COVID-19 after informed consent at Shanghai Public Health Clinical Center. […] Patients in HCQ group were given HCQ 400 mg per day for 5 days plus conventional treatments, while those in the control group were given conventional treatment only. […] One patient in HCQ group developed to severe during the treatment. […] Larger sample size study are needed to investigate the effects of HCQ in the treatment of COVID-19. 2020-05-12
[Dynamic inflammatory response in a critically ill COVID-19 patient treated with corticosteroids]. To investigate the effect of corticosteroids therapy on the inflammatory response in a critically ill coronavirus disease 2019 (COVID-19) patient. […] Thereafter, the dose was adjusted in a timely manner and the therapy lasted for 13 days. 2020-05-12
[Clinical observation of 6 severe COVID-19 patients treated with plasma exchange or tocilizumab]. To observe the clinical effect of plasma exchange and tocilizumab in treatment of patients with severe coronavirus disease 2019 (COVID-19). […] The C-reactive protein (CRP) and IL-6 levels were significantly decreased and the lymphocyte and prothrombin time were improved in 3 patients after treatment with plasma exchange; while inflammation level was not significantly decreased, and lymphocyte and prothrombin time did not improve in 3 patients treated with tocilizumab. 2020-05-12
[Clinical experience of high-flow nasal cannula oxygen therapy in severe COVID-19 patients]. We applied HFNC for oxygen therapy in severe and critical ill COVID-19 patients and summarized the following experiences. […] Thirdly, to avoid hypoxia or hypoxemia, the treatment goal of HFNC should be maintained the oxygen saturation (SpO2) above 95% for patients without chronic pulmonary disease. […] Finally, patients should wear a surgical mask during HFNC treatment to reduce the risk of virus transmission through droplets or aerosols. 2020-05-12
[Pregnant women complicated with COVID-19: a clinical analysis of 3 cases]. The report shows that COVID-19 in pregnancy women could be cured with active treatment, and the maternal and fetal outcomes can be satisfactory. 2020-05-12
[Management of a colon cancer patient complicated with COVID-19]. The inflammation indicators and fever of this patient were effectively controlled and the lung lesions remained stable after active anti-viral treatment, then the radical colorectomy was performed after the viral negative conversion for twice. 2020-05-12
[Analysis of medication characteristics of traditional Chinese medicine in treating COVID-19 based on data mining]. To analysis the medication characteristics of the prescriptions issued via open channel by the National and Provincial Health Committee and the State Administration of Traditional Chinese Medicine in treating coronavirus disease 2019 (COVID-19). […] We collected the data of traditional Chinese medicine related to treatment plans published by the National and Provincial Health Committee and the State Administration of Traditional Chinese Medicine from the start of COVID-19 outbreak to February 19, 2020. […] The study collected 4 national and 34 regional prevention and treatment plans, 578 items, 84 traditional Chinese formulations, 60 Chinese patent medicines, and 230 Chinese herbs. […] The main medication characteristics are clearing heat, entilating lung, removing toxicity and removing turbidity. 2020-05-12
CT Scans Obtained for Nonpulmonary Indications: Associated Respiratory Findings of COVID-19. Overall, the most common CT findings were ground glass opacity (114/119, 96%) and consolidation (47/119,40%). 29/119 (24%) patients required major interventions (vasopressor medication or intubation) and 27/119 (23%) died. 2020-05-11
Characteristics and clinical significance of myocardial injury in patients with severe coronavirus disease 2019. Clinical, laboratory, and treatment data were collected and compared between patients who died and survivors. 2020-05-29
[Chloroquine as a possible treatment for COVID-19]. Since the outbreak of COVID-19, chloroquine has been mentioned as a possible treatment. […] Recently, the Dutch National Institute for Public Health and the Environment published treatment options for antiviral treatment for COVID-19 where chloroquine was suggested as first choice for off-label treatment, beside remdesivir en lopinavir/ritonavir. 2020-05-20
[Respiratory complaints in the time of COVID-19]. The current guidelines for diagnosis and treatment of primary respiratory infections are still useful during the COVID-19 epidemic.Telephone triage of patients with respiratory complaints aims to identify patients with complications or an increased risk of complications.There are no indications to test for SARS-CoV-2 virus in general practice.During this COVID-19 epidemic, protective clothing is recommended in all physical contacts with patients with respiratory complaints.There is no reason to be cautious about using NSAIDs in patients suspected of COVID-19. […] Amoxicillin is first choice treatment for respiratory infections during the COVID-19 epidemic; there is lack of evidence to support azithromycin as a first choice.Respiratory rate > 24 / min or saturation <92-94% indicate imminent respiratory decompensation and may be reasons for referral. 2020-05-20
Association of Treatment With Hydroxychloroquine or Azithromycin With In-Hospital Mortality in Patients With COVID-19 in New York State. Among patients hospitalized in metropolitan New York with COVID-19, treatment with hydroxychloroquine, azithromycin, or both, compared with neither treatment, was not significantly associated with differences in in-hospital mortality. 2020-05-20
Characteristics and Outcomes of Children With Coronavirus Disease 2019 (COVID-19) Infection Admitted to US and Canadian Pediatric Intensive Care Units. While there is evidence that the burden of COVID-19 infection in hospitalized children is lesser than in their adult counterparts, to date, there are only limited reports describing COVID-19 in pediatric intensive care units (PICUs). 2020-05-11
The SARS-CoV-2 epidemic in Zimbabwe: Quo vadis? A breakdown of treatment and prevention services for these conditions may even overshadow the projected morbidity and mortality from COVID-19. 2020-05-29
The Challenges of COVID-19 for People Living With Diabetes: Considerations for Digital Health. Diabetes-related factors of glycemic control, medication pharmacodynamics, and insulin access can impact the severity of a COVID-19 infection. 2020-05-18
Treating Leukemia in the Time of COVID-19. The biology of each leukemia and its corresponding treatment with conventional intensive chemotherapy, with or without targeted therapies (venetoclax, FLT3 inhibitors, IDH1/2 inhibitors, Bruton’s tyrosine kinase inhibitors), introduce additional layers of complexity during COVID-19 high-risk periods. 2020-05-11
JAK Inhibition as a New Treatment Strategy for Patients with COVID-19. However, more studies are needed to clarify the efficacy of these therapeutics. […] In addition to antiviral therapy, potential ACE2- and AT1-R-inhibiting strategies, and other supportive care, we suggest other potential JAKinibs and novel anti-inflammatory combination therapies that affect the JAK-STAT pathway in patients with COVID-19. 2020-05-11
Israel Ad Hoc COVID-19 Committee: Guidelines for Care of Older Persons During a Pandemic. A group was formed, comprising three senior geriatricians, a former dean, a palliative care specialist, and a lawyer/ethicist. […] Recommendations included the approach to older persons both in the community and in long-term care institutions, a triage instrument, and palliative care. […] The guideline emphasized that no matter what, in the spirit of beneficence, anyone who fell ill must receive active palliative care throughout the course of a COVD-19 infection but especially at the end of life. 2020-05-23
Clotting Factors in COVID-19: Epidemiological Association and Prognostic Values in Different Clinical Presentations in an Italian Cohort. Fibrinogen seems to increase early in COVID-19 patients and may be used as a risk stratification marker for the early detection of a subgroup of COVID-19 patient at increased risk to develop SARS, who might benefit from a different and thorough clinical surveillance and treatment. 2020-05-12
SARS-CoV-2 Infection with Different Radiological Insights. This is an important issue to be identified in order to provide more specific therapy earlier, including both antiviral and anti-inflammatory drugs associated with anti anticoagulant therapy. 2020-05-12
Preparing your intensive care unit for the COVID-19 pandemic: practical considerations and strategies. Preparing intensive care units (ICU) is an integral part of any pandemic response. 2020-05-13
Perceived infection transmission routes, infection control practices, psychosocial changes, and management of COVID-19 infected healthcare workers in a tertiary acute care hospital in Wuhan: a cross-sectional survey. Perceived causes of infection, infection prevention, control knowledge and behaviour, psychological changes, symptoms and treatment were measured. 2020-05-14
‘Scientific Strabismus’ or Two Related Pandemics: COVID-19 & Vitamin D Deficiency. Given its rare side effects and relatively wide safety, prophylactic vitamin D supplementation and/or food fortification might reasonably serve as a very convenient adjuvant therapy for these two worldwide public health problems alike. 2020-05-12
Intelligent classification of platelet aggregates by agonist type. The method is a powerful tool for studying the underlying mechanism of platelet aggregation and is expected to open a window on an entirely new class of clinical diagnostics, pharmacometrics, and therapeutics. […] Blood clots have also been linked to harmful inflammation and the spread of cancer, and there are now preliminary reports of remarkably high rates of clotting in COVID-19 patients in intensive care units. […] This could help them choose whether aspirin or another anti-platelet drug would be the best treatment. 2020-05-14
Non-communicable disease management in vulnerable patients during Covid-19. Temporary closure of outpatient health facilities in some secondary and tertiary care hospitals have deprived millions of NCD patients of their regular medication and diagnostic health needs. 2020-05-14
The ICMR bulletin on targeted hydroxychloroquine prophylaxis for Covid-19: Need to interpret with caution. The WHO and the FDA have not found adequate evidence to recommend any specific medication for the treatment of Covid-19. 2020-05-14
Management of patients with COPD during the COVID-19 pandemic. Management of COPD with COVID-19 warrants standard-of-care treatment with antimicrobial agents and corticosteroids, though limiting the dose and duration of steroids use may be warranted due to the risk of increased viral shedding. 2020-05-12
Keeping lupus patients on hydroxychloroquine during the COVID-19 pandemic. HCQ is the only SLE treatment shown to increase survival and any change in the HCQ regimen is potentially dangerous. […] Providers need to make thoughtful, informed decisions in this time of medication shortage. 2020-05-12
Hydroxychloroquine in Patients with Rheumatic Disease Complicated by COVID-19: Clarifying Target Exposures and the Need for Clinical Trials. We found that the average patient receiving treatment with hydroxychloroquine for rheumatic diseases, including children and non-pregnant/pregnant adults, are unlikely to achieve total serum or plasma concentrations shown to inhibit SARS-CoV-2 in-vitro. 2020-05-12
Therapeutic targets and signaling mechanisms of vitamin C activity against sepsis: a bioinformatics study. Evidence of the benefits of vitamin C (VC) for the treatment of sepsis is accumulating. 2020-05-12
A cloth mask for under-resourced healthcare settings in the COVID19 pandemic. Prevention and risk reduction strategies are paramount in the current absence of effective treatment or a vaccine. 2020-05-15
Sudden death due to acute pulmonary embolism in a young woman with COVID-19. Rarely, pulmonary embolism may be encountered in patients with severe COVID-19 infection, especially in intensive care units. 2020-05-15
End-of-life care in patients with a highly transmissible respiratory virus: implications for COVID-19. The current coronavirus disease (COVID-19) pandemic has caused significant mortality over a short time and has necessitated an increase in provision of both critical care and palliative care. 2020-05-15
COVID-19 in people living with human immunodeficiency virus: a case series of 33 patients. All patients were on antiretroviral treatment, of them 22 on tenofovir-containing regimen and 4 on the protease inhibitor darunavir. 2020-05-15
Recommendations for Trauma and Emergency General Surgery Practice During COVID-19 Pandemic. On the other hand, patients, who need emergency healthcare, should also be provided with appropriate treatment. […] Healthcare professionals should choose a treatment method appropriately in the circumstances to protect themselves and their patients as much as possible. 2020-05-13
A global treatments for coronaviruses including COVID-19. Neuraminidase inhibitors such as oseltamivir, peramivir, and zanamivir are invalid for 2019-nCoV and are not recommended for treatment but protease inhibitors such as lopinavir/ritonavir (LPV/r) inhibit the progression of MERS-CoV disease and can be useful for patients of COVID-19 and, in combination with Arbidol, has a direct antiviral effect on early replication of SARS-CoV. […] Favipiravir increases clinical recovery and reduces respiratory problems and has a stronger antiviral effect than LPV/r. currently, appropriate treatment for patients with COVID-19 is an ACE2 inhibitor and a clinical problem reducing agent such as favipiravir in addition to hydroxychloroquine and corticosteroids. 2020-05-12
Genesis of an emergency public drug information website by the French Society of Pharmacology and Therapeutics during the COVID-19 pandemic. On March 16, 2020, the French Society of Pharmacology and Therapeutics put online a national Question and Answer (Q&A) website, https://sfpt-fr.org/covid19 on the proper use of drugs during the COVID-19 pandemic. 2020-05-12
COVID-19 and comorbidities: A role for dipeptidyl peptidase 4 (DPP4) in disease severity? The importance of DPP4 for the medical community has been highlighted by the approval of DPP4 inhibitors, or gliptins, for the treatment of type 2 diabetes mellitus. 2020-05-27
To Do or Not to Do?-A Review of Cancer Surgery Triage Guidelines in COVID-19 Pandemic. Due to overall rising cancer incidence and specific concerns, a cohort of cancer patients forms a distinct subset of the population in whom a correct and timely treatment has a huge impact on the outcome. 2020-05-15
Successful COVID-19 rescue therapy by extra-corporeal membrane oxygenation (ECMO) for respiratory failure: a case report. The value of extracorporeal membrane oxygenation (ECMO) for patients suffering from novel coronavirus disease 2019 (COVID-19) as a rescue therapy for respiratory failure remains controversial and associated with high mortality rates of 50 to 82% in early reports from Wuhan, China. […] We hypothesized that patient outcomes would be improved at our tertiary cardiothoracic surgery referral center with a protocolized team-approach for ECMO treatment of patients with severe COVID-19 disease. […] Her respiratory status continued to deteriorate despite maximized critical care, including prone positioning ventilation and nitric oxide inhalation therapy. […] Veno-venous ECMO was initiated on hospital day 7 in conjunction with a 10-day course of compassionate use antiviral treatment with remdesivir. […] This case report demonstrates a positive outcome in a young patient with COVID-19 treated by the judicious application of ECMO in conjunction with compassionate use antiviral treatment (remdesivir). 2020-05-15
COVID-19: a look into the modern age pandemic. More research is required, especially in the treatment and prevention of the disease, so that we may progress towards finding a cure as well as creating a vaccine for the COVID-19. 2020-05-15
An Update on Current Therapeutic Drugs Treating COVID-19. In this review, we will update and summarize the most common and plausible drugs for the treatment of COVID-19 patients. 2020-05-15
Hot Topic Commentary on COVID-19. In this special Theme issue, we would like to discuss the latest treatment modalities available around the world in tackling this dreadful disease. 2020-05-15
The effect of RAS blockers on the clinical characteristics of COVID-19 patients with hypertension. Previous experimental data revealed ACE2 level was increased following treatment with ACE inhibitors (ACEIs) and angiotensin receptor blockers (ARBs). 2020-05-15
The challenges in colorectal cancer management during COVID-19 epidemic. Also, treatment principles may various for CRC patients with or without severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, as well as patients with or without an emergency presentation. 2020-05-15
2019 novel coronavirus pneumonia with onset of dizziness: a case report. At last, the prognosis was good after active treatment. […] After antiviral and anti-infective treatment, the symptoms recovered. 2020-05-15
Molecular docking and dynamic simulations for antiviral compounds against SARS-CoV-2: A computational study. The strategy in virtual screening of antiviral databases for possible therapeutic effect would be to identify promising drug molecules, as there is currently no vaccine or treatment approved against COVID-19. 2020-05-27
Guidelines to Reduce Hospitalization Rates for Patients Receiving Curative-Intent Radiation Therapy During the COVID-19 Pandemic: Report from a Multicenter New York Area Institution. As the COVID-19 pandemic spreads around the globe, access to radiation therapy remains critical for cancer patients. […] The priority for all radiation oncology departments is to protect the staff and to maintain operations in providing access to those patients requiring radiation therapy services. […] Patients with tumors of the aerodigestive tract and pelvis amongst others often experience toxicity during treatment, and there is a baseline risk that adverse effects may require hospital-based management. […] Routine care during weekly visits is important to guide patients through treatment and to mitigate against the need for hospitalization. […] Recognizing the need to provide access to treatment and the anticipated toxicity of such treatment, we have developed and implemented guidelines for clinical care management with the hope of avoiding added risk to our patients. 2020-05-15
Assessing the validity of the Australian Treatment Outcomes Profile for telephone administration in drug health treatment populations. The Australian Treatment Outcomes Profile (ATOP) is a brief clinical tool measuring recent substance use, health and wellbeing among clients attending alcohol and other drug (AOD) treatment services. […] We recruited a sample of 107 AOD clients across public sector specialist AOD treatment services in New South Wales, Australia between 2016 and 2018. […] Among 107 participants, 59% were attending for alcohol treatment and 41% for opioid treatment. 2020-05-12
Endocrinology in the time of COVID-19: Management of calcium disorders and osteoporosis. Patients established on denosumab and teriparatide should continue planned therapy. 2020-05-12
Clinical and laboratory findings from patients with COVID-19 pneumonia in Babol North of Iran: a retrospective cohort study. Therefore, it is best to be regularly assessed these markers during treatment of COVID-19 patients. 2020-05-12
Development and Validation of a Clinical Risk Score to Predict the Occurrence of Critical Illness in Hospitalized Patients With COVID-19. Early identification of patients with novel corona virus disease 2019 (COVID-19) who may develop critical illness is of great importance and may aid in delivering proper treatment and optimizing use of resources. 2020-05-20
Myth Busters: Dietary Supplements and COVID-19. News and social media platforms have implicated dietary supplements in the treatment and prevention of coronavirus disease 2019 (COVID-19). […] Rather, reference to evidence-based guidelines should guide treatment decisions. 2020-05-12
Managing Diabetes in Pregnancy Before, During, and After COVID-19. Case histories describe the remote initiation of insulin pump therapy and automated insulin delivery in T1D pregnancy. Results: Initial feedback suggests that video consultations are well received and that the patient experiences for women requiring face-to-face visits are greatly improved. 2020-05-19
Approaching Otolaryngology Patients During the COVID-19 Pandemic. Data on demographics, comorbidities, COVID-19 symptoms and severity, consult reason, treatment, and personal protective equipment (PPE) use were collected and analyzed. […] Otolaryngologists play an indispensable role in the treatment of COVID-19 patients but, due to their work, are at high risk of exposure. 2020-05-15
Otologic and Audiologic Considerations for COVID-19. Here we present considerations in regard to treatment with quinine-derived drugs and the influence of masks on communication. 2020-05-12
Elective Tracheostomy During Mechanical Ventilation in Patients Affected by COVID-19: Preliminary Case Series From Lombardy, Italy. The COVID-19 outbreak poses continued struggles due to the unprecedented number of patients admitted to intensive care units and the overwhelming need for mechanical ventilation. 2020-05-12
Clinical orthodontic management during the COVID-19 pandemic. To provide a comprehensive summary of the implications of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and coronavirus disease 2019 (COVID-19) on orthodontic treatment, contingency management, and provision of emergency orthodontic treatment, using currently available data and literature. […] During the spread of the COVID-19 pandemic, elective orthodontic treatment should be suspended and resumed only when permitted by federal, provincial, and local health regulatory authorities. […] Emergency orthodontic treatment can be provided by following a contingency plan founded on effective communication and triage. […] Treatment advice should be delivered remotely first when possible, and where necessary, in-person treatment can be performed in a well-prepared operatory following the necessary precautions and infection prevention and control (IPAC) protocol. 2020-05-12
The SARS-CoV-2/COVID-19 pandemic and challenges in stroke care in India. Stroke care in India has evolved rapidly in the last decade with a focus on stroke awareness, prevention, rapid triage, treatment, and rehabilitation. […] There is a need for public health systems in both developed and developing countries to improve awareness, implement proper strategies of triage, acute treatment, well-defined rehabilitation plans, telemedicine services, and virtual check-ins. 2020-05-12
Remdesivir in the treatment of coronavirus disease 2019 (COVID-19): a simplified summary. Remdesivir has been recently a strong candidate for the treatment of Covid-19. […] Therefore, future disposal of agents such as remdesivir might be crucial for ensuring an efficient treatment, decrease mortality and allow early discharge.Communicated by Ramaswamy H. 2020-05-30
Truncated human angiotensin converting enzyme 2; a potential inhibitor of SARS-CoV-2 spike glycoprotein and potent COVID-19 therapeutic agent. Furthermore, prediction of tACE2 soluble expression in E. coli makes it a suitable candidate to be targeted for Covid-19 therapeutics. 2020-05-30
Venous Thromboembolism Complicated with COVID-19: What Do We Know So Far? Presently, the incidence of VTE is estimated at around 25% of patients hospitalized in the intensive care unit for COVID-19 even under anticoagulant treatment at prophylactic doses. […] In this review, we discuss present knowledge of the topic, the unique challenges of diagnosis and treatment of VTE, as well as some of the potential mechanisms of increased risk for VTE during the illness. […] Understanding the true impact of VTE on patients with COVID-19 will potentially improve our ability to reach a timely diagnosis and initiate proper treatment, mitigating the risk for this susceptible population during a complicated disease. 2020-05-12
Risk of COVID-19 in young kidney transplant recipients. Results from a single-center observational study. Children/young adults seem to have a less severe clinical manifestation of COVID-19 (2), but data on disease susceptibility in pediatric transplant recipients on chronic immunosuppressive therapy are limited (3, 4). […] This poses major uncertainties regarding pediatric transplant activity and management of anti-rejection therapy. 2020-05-12
Immune response to SARS-CoV-2 and mechanisms of immunopathological changes in COVID-19. There is a pressing need to improve our understanding of the immunology of this disease to contain the pandemic by developing vaccines and medicines for the prevention and treatment of patients. 2020-05-12
The role of telemedicine in the delivery of healthcare in the COVID-19 Pandemic. Accordingly, such measures have led to concerns over how to maintain access to haemophilia treatment products and to the specialized integrated care medical follow up within the haemophilia treatment centers (HTCs). 2020-05-12
Cytokine Release Syndrome in COVID-19 Patients, A New Scenario for an Old Concern: The Fragile Balance between Infections and Autoimmunity. Indeed, treatment of CRS involves the use of both antivirals to control the underlying infection and immunosuppressive agents to dampen the aberrant pro-inflammatory response of the host. […] Autoimmune patients receiving immunosuppressants could be prone to SARS-CoV-2 infections; however, suspension of the ongoing therapy is contraindicated to avoid disease flares and a consequent increase in the infection risk. 2020-05-14
Tocilizumab for Treatment of Severe COVID-19 Patients: Preliminary Results from SMAtteo COvid19 REgistry (SMACORE). Objective: This study aimed to assess the role of Tocilizumab therapy (TCZ) in terms of ICU admission and mortality rate of critically ill patients with severe COVID-19 pneumonia. Design: Patients with COVID-19 pneumonia were prospectively enrolled in SMAtteo COvid19 REgistry (SMACORE). […] This study found that treatment with TCZ did not significantly affect ICU admission (OR 0.11; 95% CI between 0.00 and 3.38; p = 0.22) or 7-day mortality rate (OR 0.78; 95% CI between 0.06 and 9.34; p = 0.84) when compared with SOC. […] Analysis of laboratory measures showed significant interactions between time and treatment regarding C-Reactive Protein (CRP), alanine aminotransferase (ALT), platelets and international normalized ratio (INR) levels. […] Variation in lymphocytes count was observed over time, irrespective of treatment. Conclusions: TCZ administration did not reduce ICU admission or mortality rate in a cohort of 21 patients. 2020-05-13
SARS-CoV-2 Inflammatory Syndrome. Clinical Features and Rationale for Immunological Treatment. The current pandemic coronavirus, SARS-CoV-2, is a global health emergency because of its highly contagious nature, the great number of patients requiring intensive care therapy, and the high fatality rate. […] In the absence of specific antiviral drugs, passive prophylaxis, or a vaccine, the treatment aim in these patients is to prevent the potent virus-induced inflammatory stimuli from leading to the acute respiratory distress syndrome (ARDS), which has a severe prognosis. 2020-05-14
SARS-CoV-2/COVID-19: Viral Genomics, Epidemiology, Vaccines, and Therapeutic Interventions. Moreover, we provide an extensive list of resources that will help the scientific community access numerous types of databases related to SARS-CoV-2 OMICs and approaches to therapeutics related to COVID-19 treatment. 2020-05-19
Identification of bioactive molecules from tea plant as SARS-CoV-2 main protease inhibitors. The lack of targeted therapeutics and limited treatment options have triggered the scientific community to develop new vaccines or small molecule therapeutics against various targets of SARS-CoV-2. 2020-05-30
Drug repurposing against COVID-19: focus on anticancer agents. Drug repurposing/repositioning, a strategy effectively employed in cancer treatment, can represent a valid alternative. […] Most drugs considered for repurposing/repositioning in the therapy of the COVID-19 outbreak are commercially available and their dosage and toxicity in humans is well known, due to years (or even decades) of clinical use. […] Several drugs being re-considered for COVID-19 therapy are or have been used in cancer therapy. […] We present here a comprehensive analysis of available information on potential candidate cancer drugs that can be repurposed for the treatment of COIVD-19. 2020-05-14
Impact of PD-1 blockade on severity of COVID-19 in patients with lung cancers. It is currently unknown whether PD-1 blockade therapy impacts severity of illness from COVID-19 in patients with cancer. 2020-05-13
Lung ultrasound in the monitoring of COVID-19 infection. The patient’s condition improved after adjustment of therapy at home. […] We emphasise the utility and the opportunity that LUS presents in some clinical scenarios, like this COVID-19 pandemic, and how it may serve as a monitoring and therapy guide. 2020-05-13
Should azithromycin be used to treat COVID-19? A rapid review. While novel drugs are being developed, azithromycin has been identified as a candidate treatment in the interim. […] In vivo and in vitro studies were included assessing the safety and effectiveness of azithromycin for treatment of COVID-19, and/or the activity of azithromycin against SARS-CoV-2. […] There is no evidence to support the use of azithromycin for the treatment of COVID-19 outside of the context of clinical trials, unless it is used to treat bacterial super-infection. 2020-05-13
Recommendations of the Main Board of the Polish Society of Otorhinolaryngologists, Head and Neck Surgeons for providing services during the COVID-19 pandemic for outpatient and hospital practices. We provide the rationale for launching medical activities and indicate optimal practices until the consolidation of SARS COV-2 prevention and treatment methods. 2020-05-14
COVID-19 in Children, Pregnancy and Neonates: A Review of Epidemiologic and Clinical Features. Children rarely needed admission to intensive care units (3%), and to date, only a small number of deaths have been reported in children globally. 2020-05-18
Reorganizing the treatment of cardiovascular disease in response to coronavirus disease 2019; time for the polypill? Combination therapy is well established in hypertension. […] Many guidelines recommend dual antihypertensive therapy as the initial treatment step as this results in faster blood pressure control, albeit with limited evidence of improved outcomes. […] Control of CVD risk factors through multiclass combination therapy (the polypill) was proposed many years ago. 2020-05-13
A serological assay to detect SARS-CoV-2 seroconversion in humans. Serological assays are of critical importance to help define previous exposure to SARS-CoV-2 in populations, identify highly reactive human donors for convalescent plasma therapy and investigate correlates of protection. 2020-05-13
In the midst of the perfect storm: swift public health actions needed in order to increase societal safety during the COVID-19 pandemic. The limited biomedical and epidemiological understanding of COVID-19 along with the lack of vaccines and therapeutics have led to the reception of draconian measures from the societal safety domain, limiting human interaction through social distancing. 2020-05-28
Characterize health and economic vulnerabilities of workers to control the emergence of COVID-19 in an industrial zone in Vietnam. Self-treatment (without medication) was the most used method when having health problems (by 28.2% to 51% of participants), followed by visiting commune health centers (24%) and self-medication (20.3%). 2020-05-16
Deep Vein Thrombosis and Pulmonary Embolism: Two Complications of COVID-19 Pneumonia? Anticoagulant treatment is associated with decreased mortality in severe COVID-19 pneumonia. 2020-05-16
Co-infection with Influenza A and COVID-19. COVID-19 can co-occur with other viral infections.Some of these co-infections have active treatments, while supportive treatment is the mainstay of treatment for others. 2020-05-16
Tocilizumab in Severe COVID-19 Pneumonia and Concomitant Cytokine Release Syndrome. There is no proven antiviral therapy for COVID-19 so far, but profound immunosuppression has recently been suggested as a treatment for COVID-19-associated CRS. […] We present a case of life-threatening CRS caused by COVID-19 infection with a favourable response to immunosuppressive therapy with tocilizumab (TCZ). […] The rapid clinical and biochemical improvement following TCZ administration suggests that treatment with immunotherapy can be life-saving in selected patients with COVID-19-induced CRS. […] Cytokine release syndrome may cause sudden and potentially life-threatening clinical deterioration in COVID-19 pneumonia, particularly in younger patients.Immunosuppressive therapy may provide important additional therapeutic benefit in these patients.Tocilizumab, a specific IL-6 inhibitor, led to dramatic clinical improvement in a young patient with severe COVID-19-associated cytokine release syndrome. 2020-05-16
Cerebral Venous Sinus Thrombosis as a Presentation of COVID-19. These thrombotic events include stroke, venous thromboembolism, pulmonary embolism and cardiac complications.Clinicians should carefully consider the risk of thrombosis in patients positive for COVID-19, including prophylaxis and treatment beyond discharge. 2020-05-16
Computed tomography findings in a case of coronavirus disease 2019. The preferred imaging modality is chest computed tomography (CT) which plays an important role in early diagnosis, quarantine, and treatment as well as in the evaluation of therapeutic efficacy. 2020-05-13
Novel coronavirus disease 2019 (COVID-19): relationship between chest CT scores and laboratory parameters. Median chest CT scores peaked at 4 days after the beginning of treatment and then declined. 2020-05-16
Involvement of the Nervous System in SARS-CoV-2 Infection. CNS symptoms could be a potential indicator of poor prognosis; therefore, the prevention and treatment of CNS symptoms are also crucial for the recovery of COVID-19 patients. 2020-05-29
Is COVID-19 a New Hematologic Disease? Hematologic consequences of this new infection allowed medical community to start new treatment approaches concerning infection going from targeted anti-inflammatory drugs to anticoagulation or stem cell therapies. […] A better understanding of Covid-19 pathophysiology, in particular hematological disorders, will help to choose appropriate treatment strategies. 2020-05-16
Ethical considerations for allocation of scarce resources and alterations in surgical care during a pandemic. The allocation of hospital beds and ventilators, personal protective equipment, investigational therapeutics, and other scarce resources has required difficult decisions. 2020-05-16
Impact of the Covid-19 outbreak on acute stroke pathways - Insights from the Alsace region in France. To date, no study attempted to quantify the impact of the Covid-19 outbreak on incidence and treatment of acute stroke. 2020-05-13
Invasive strategy for COVID patients presenting with acute coronary syndrome: The first multicenter Italian experience. The rapid diffusion of the SARS-CoV-2 together with the need for isolation for infected patients might be responsible for a suboptimal treatment for SARS-CoV-2 ACS patients. 2020-05-13
COVID-19 pneumonia in lung transplant recipients: report of two cases. The first patient always maintained excellent oxygen saturation throughout hospitalization with no need for additional oxygen therapy. 2020-05-13
SARS-CoV-2 infection in two patients following recent lung transplantation. Both patients were on triple immunosuppressive therapy and had no signs of allograft dysfunction. […] Immunosuppressive therapy was unchanged and no experimental treatment was initiated. 2020-05-13
[Lack of clinical evidence for the use of hydroxychloroquine to treat SARS-CoV-2 infection]. This review aims to elucidate potential mechanisms, which make HCQ treatment interesting in the fight against SARS-CoV-2 infection, as well as the current evidence for clinical use of HCQ to treat COVID-19. 2020-05-18
Cognitive Processing Therapy for Posttraumatic Stress Disorder via Telehealth: Practical Considerations During the COVID-19 Pandemic. Cognitive processing therapy (CPT) is a trauma-focused, evidence-based treatment for posttraumatic stress disorder that is effective when delivered in-person or via telehealth. […] Given current limitations on the provision of in-person mental health treatment during the COVID-19 pandemic, this article presents guidelines and treatment considerations when implementing CPT via telehealth. […] Based on lessons learned from prior studies and clinical delivery of CPT via telehealth, recommendations are made with regard to overall strategies for adapting CPT to a telehealth format, including how to conduct routine assessments and ensure treatment fidelity. 2020-05-13
The COVID-19 pandemic: A rapid global response for children with cancer from SIOP, COG, SIOP-E, SIOP-PODC, IPSO, PROS, CCI, and St Jude Global. The COVID-19 pandemic is one of the most serious global challenges to delivering affordable and equitable treatment to children with cancer we have witnessed in the last few decades. […] We provide some practical advice for adapting diagnostic and treatment protocols for children with cancer during the pandemic, the measures taken to contain it (e.g., extreme social distancing), and how to prepare for the anticipated recovery period. 2020-05-29
Coronavirus disease 2019 and transplantation: The combination of lopinavir/ritonavir and hydroxychloroquine is responsible for excessive tacrolimus trough level and unfavorable outcome. These drugs may be used tentatively for general population with COVID-19, but for solid organ transplant (SOT) recipients with long-term immunosuppressive therapy and drug-related metabolic diseases, antiviral drugs should be chosen with particular care. 2020-05-13
CRISPR-cas systems based molecular diagnostic tool for infectious diseases and emerging 2019 novel coronavirus (COVID-19) pneumonia. The current outbreak of pneumonia caused by 2019 novel coronavirus (COVID-19) illustrated difficulties in lack of effective drugs for treatment. […] Accurate and rapid diagnostic tools are essential for early recognition and treatment of infectious diseases, allowing timely implementation of infection control, improved clinical care and other public health measures to stop the spread of the disease. 2020-05-26
Recovery from COVID-19 in two patients with coexisted HIV infection. One patient with prior HIV-infection continued anti-HIV treatment when diagnosed with COVID-19. […] The other patient was newly diagnosed with HIV-infection when diagnosed with COVID-19 and had not begun anti-HIV treatment. […] Both patients were treated with anti-viral, antibiotics, oxygen treatment and supportive care and recovered from severe pneumonia. 2020-05-13
Managing haematology and oncology patients during the COVID-19 pandemic: interim consensus guidance. Patients with cancer may have compromised immunity due to their malignancy and/or treatment, and may be at elevated risk of severe COVID-19. […] During the COVID-19 pandemic: In patients with cancer with fever and/or respiratory symptoms, consider causes in addition to COVID-19, including other infections and therapy-related pneumonitis. […] For suspected or confirmed COVID-19, discuss temporary cessation of cancer therapy with a relevant specialist. […] Communicate treatment modifications, and review once health service capacity allows. […] Discuss and document goals of care, and involve palliative care services in contingency planning. […] Australasian Leukaemia and Lymphoma Group; Australasian Lung Cancer Trials Group; Australian and New Zealand Children’s Haematology/Oncology Group; Australia and New Zealand Society of Palliative Medicine; Australasian Society for Infectious Diseases; Bone Marrow Transplantation Society of Australia and New Zealand; Cancer Council Australia; Cancer Nurses Society of Australia; Cancer Society of New Zealand; Clinical Oncology Society of Australia; Haematology Society of Australia and New Zealand; National Centre for Infections in Cancer; New Zealand Cancer Control Agency; New Zealand Society for Oncology; and Palliative Care Australia. 2020-05-31
Clinical Characteristics of Re-hospitalized Patients with COVID-19 in China. 3 People’s Hospital of Jianghan University for a second treatment in March 2020. 2020-05-13
Protecting dental manpower from COVID 19 infection. Covid-19 currently has no known treatment or a vaccine. 2020-05-13
Antihyperglycemic properties of hydroxychloroquine in patients with diabetes: ri