Clinical, signs & Symptoms Sentence Context

Table 1. Analysis of context sentence of 47204 absracts clustered as Clinical, signs & Symptoms.

Title Gene Context Sentence ePubDate
Recent advances in the detection of respiratory virus infection in humans. Conventional diagnostic tests, such as the assays for rapid detection of antiviral antibodies or viral antigens, are widely used in many clinical laboratories. 2020-03-19
[Jungle yellow fever with positive serology for leptospira in a young peruvian male]. Despite the severity of the clinical condition, he evolved favorably. 2020-01-23
Coronavirus infections and immune responses. In this review, we provide an update on CoV infections and relevant diseases, particularly the host defense against CoV-induced inflammation of lung tissue, as well as the role of the innate immune system in the pathogenesis and clinical treatment. 2020-03-19
A familial cluster of pneumonia associated with the 2019 novel coronavirus indicating person-to-person transmission: a study of a family cluster. In this study, we report the epidemiological, clinical, laboratory, radiological, and microbiological findings of five patients in a family cluster who presented with unexplained pneumonia after returning to Shenzhen, Guangdong province, China, after a visit to Wuhan, and an additional family member who did not travel to Wuhan. […] Five family members (aged 36-66 years) presented with fever, upper or lower respiratory tract symptoms, or diarrhoea, or a combination of these 3-6 days after exposure. […] Older patients (aged >60 years) had more systemic symptoms, extensive radiological ground-glass lung changes, lymphopenia, thrombocytopenia, and increased C-reactive protein and lactate dehydrogenase levels. 2020-03-13
Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. We report the epidemiological, clinical, laboratory, and radiological characteristics and treatment and clinical outcomes of these patients. […] Common symptoms at onset of illness were fever (40 [98%] of 41 patients), cough (31 [76%]), and myalgia or fatigue (18 [44%]); less common symptoms were sputum production (11 [28%] of 39), headache (three [8%] of 38), haemoptysis (two [5%] of 39), and diarrhoea (one [3%] of 38). […] Major gaps in our knowledge of the origin, epidemiology, duration of human transmission, and clinical spectrum of disease need fulfilment by future studies. 2020-03-13
Detection of 2019 novel coronavirus (2019-nCoV) by real-time RT-PCR. Through coordination between academic and public laboratories, we confirmed assay exclusivity based on 297 original clinical specimens containing a full spectrum of human respiratory viruses. 2020-02-19
Updated understanding of the outbreak of 2019 novel coronavirus (2019-nCoV) in Wuhan, China. Fever (64.7%) and cough (52.9%) were the most common first symptoms among those who died. 2020-03-19
Receptor Recognition by the Novel Coronavirus from Wuhan: an Analysis Based on Decade-Long Structural Studies of SARS Coronavirus. Recently, a novel coronavirus (2019-nCoV) has emerged from Wuhan, China, causing symptoms in humans similar to those caused by severe acute respiratory syndrome coronavirus (SARS-CoV). 2020-03-23
Drug treatment options for the 2019-new coronavirus (2019-nCoV). However, the efficacy and safety of these drugs for 2019- nCoV still need to be further confirmed by clinical experiments. 2020-03-18
Identification of a novel coronavirus causing severe pneumonia in human: a descriptive study. We collected clinical data and bronchoalveolar lavage (BAL) specimens from five patients with severe pneumonia from Jin Yin-tan Hospital of Wuhan, Hubei province, China. 2020-02-12
First Case of 2019 Novel Coronavirus in the United States. We report the first case of 2019-nCoV infection confirmed in the United States and describe the identification, diagnosis, clinical course, and management of the case, including the patient’s initial mild symptoms at presentation with progression to pneumonia on day 9 of illness. […] This case highlights the importance of close coordination between clinicians and public health authorities at the local, state, and federal levels, as well as the need for rapid dissemination of clinical information related to the care of patients with this emerging infection. 2020-03-16
Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study. We aimed to further clarify the epidemiological and clinical characteristics of 2019-nCoV pneumonia. […] Cases were confirmed by real-time RT-PCR and were analysed for epidemiological, demographic, clinical, and radiological features and laboratory data. […] Patients had clinical manifestations of fever (82 [83%] patients), cough (81 [82%] patients), shortness of breath (31 [31%] patients), muscle ache (11 [11%] patients), confusion (nine [9%] patients), headache (eight [8%] patients), sore throat (five [5%] patients), rhinorrhoea (four [4%] patients), chest pain (two [2%] patients), diarrhoea (two [2%] patients), and nausea and vomiting (one [1%] patient). 2020-03-13
Novel coronavirus: From discovery to clinical diagnostics. We have described the discovery, emergence, genomic characteristics, and clinical diagnostics of 2019-nCoV. 2020-03-18
RNA based mNGS approach identifies a novel human coronavirus from two individual pneumonia cases in 2019 Wuhan outbreak. The two patients shared common clinical features including fever, cough, and multiple ground-glass opacities in the bilateral lung field with patchy infiltration. 2020-03-16
The Novel Coronavirus: A Bird’s Eye View. Herein, we present on an overview of the currently available information on the pathogenesis, epidemiology, clinical presentation, diagnosis, and treatment of this virus. 2020-04-13
[Diagnosis and clinical management of 2019 novel coronavirus infection: an operational recommendation of Peking Union Medical College Hospital (V2.0)]. The clinical features include fever, coughing, shortness of breath, and inflammatory pulmonary infiltration revealed by X ray. 2020-02-05
[2019-nCoV: new challenges from coronavirus]. The outbreak of pneumonia caused by the novel coronavirus 2019-nCoV in Wuhan, Hubei province of China, at the end of 2019 shaped tremendous challenges to China’s public health and clinical treatment. […] The virus belongs to the β genus Coronavirus in the family Corornaviridae, and is closely related to SARS-CoV and MERS-CoV, causing severe symptoms of pneumonia. […] After the outbreak of this disease, Chinese scientists invested a lot of energy to carry out research by developing rapid diagnostic reagents, identifying the characters of the pathogen, screening out clinical drugs that may inhibit the virus, and are rapidly developing vaccines. 2020-02-05
[Efficient management of novel coronavirus pneumonia by efficient prevention and control in scientific manner]. Based on current studies, the author summarized the clinical characteristics and evolution of the novel viral pneumonia, and proposed the key points of diagnosis and treatment, the scientific management of both confirmed and suspected cases, and the scientific management of disease prevention and control. 2020-02-05
[Potential antiviral therapeutics for 2019 Novel Coronavirus]. Antiviral drugs commonly used in clinical practice, including neuraminidase inhibitors (oseltamivir, paramivir, zanamivir, etc.), ganciclovir, acyclovir and ribavirin, are invalid for 2019-nCoV and not recommended. […] But the efficacy and safety of these drugs for 2019-nCoV pneumonia patients need to be assessed by further clinical trials. 2020-02-05
[Early detection and disease assessment of patients with novel coronavirus pneumonia]. The novel coronavirus has the characteristics of rapid transmission, atypical clinical symptoms, and easy to affect both lungs, leading to missed diagnosis and misdiagnosis, as well as difficult to detection and assessment at early stage. 2020-02-05
Diagnosis and treatment recommendations for pediatric respiratory infection caused by the 2019 novel coronavirus. Following the latest National recommendations for diagnosis and treatment of pneumonia caused by 2019-nCoV (the 4th edition) and current status of clinical practice in Zhejiang Province, recommendations for the diagnosis and treatment of respiratory infection caused by 2019-nCoV for children were drafted by the National Clinical Research Center for Child Health, the National Children’s Regional Medical Center, Children’s Hospital, Zhejiang University School of Medicine to further standardize the protocol for diagnosis and treatment of respiratory infection in children caused by 2019-nCoV. 2020-02-06
[Analysis of clinical features of 29 patients with 2019 novel coronavirus pneumonia]. Objective: To analyze the clinical characteristics of 2019 novel coronavirus (2019-nCoV) pneumonia and to investigate the correlation between serum inflammatory cytokines and severity of the disease. Methods: 29 patients with 2019-ncov admitted to the isolation ward of Tongji hospital affiliated to Tongji medical college of Huazhong University of Science and Technology in January 2020 were selected as the study subjects. […] Clinical data were collected and the general information, clinical symptoms, blood test and CT imaging characteristics were analyzed. […] The expression levels of inflammatory cytokines and other markers in the serum of each group were detected, and the changes of these indicators of the three groups were compared and analyzed, as well as their relationship with the clinical classification of the disease. Results: (1) The main symptoms of 2019-nCoV pneumonia was fever (28/29) with or without respiratory and other systemic symptoms. […] However, there were no statistically significant differences in serum levels of tumor necrosis factor-alpha (TNF-α), IL-1, IL-8, IL-10, hs-CRP, lymphocyte count and LDH among the three groups (P>0.05). Conclusion: The clinical characteristics of 2019-nCoV pneumonia are similar to those of common viral pneumonia. 2020-02-06
Emerging 2019 Novel Coronavirus (2019-nCoV) Pneumonia. BackgroundThe chest CT findings of patients with 2019 Novel Coronavirus (2019-nCoV) pneumonia have not previously been described in detail.PurposeTo investigate the clinical, laboratory, and imaging findings of emerging 2019-nCoV pneumonia in humans.Materials and MethodsFifty-one patients (25 men and 26 women; age range 16-76 years) with laboratory-confirmed 2019-nCoV infection by using real-time reverse transcription polymerase chain reaction underwent thin-section CT. […] The imaging findings, clinical data, and laboratory data were evaluated.ResultsFifty of 51 patients (98%) had a history of contact with individuals from the endemic center in Wuhan, China. […] Fever (49 of 51, 96%) and cough (24 of 51, 47%) were the most common symptoms. 2020-03-20
The First Case of 2019 Novel Coronavirus Pneumonia Imported into Korea from Wuhan, China: Implication for Infection Prevention and Control Measures. We report the epidemiological and clinical features of the first patient with 2019-nCoV pneumonia imported into Korea from Wuhan. 2020-03-16
Clinical Characteristics of 138 Hospitalized Patients With 2019 Novel Coronavirus-Infected Pneumonia in Wuhan, China. The number of cases has increased rapidly but information on the clinical characteristics of affected patients is limited. […] To describe the epidemiological and clinical characteristics of NCIP. […] Epidemiological, demographic, clinical, laboratory, radiological, and treatment data were collected and analyzed. […] Common symptoms included fever (136 [98.6%]), fatigue (96 [69.6%]), and dry cough (82 [59.4%]). 2020-03-13
The Rate of Underascertainment of Novel Coronavirus (2019-nCoV) Infection: Estimation Using Japanese Passengers Data on Evacuation Flights. All passengers were screened upon arrival in Japan for symptoms consistent with novel coronavirus (2019-nCoV) infection and tested for presence of the virus. 2020-03-20
[Suggestions for disinfection of ophthalmic examination equipment and protection of ophthalmologist against 2019 novel coronavirus infection]. It is extremely important to disinfect ophthalmic examination instruments and protect ophthalmic medical care during the epidemic period to reduce cross-infection in clinical practice and reduce the infection risk of ophthalmic medical staff. (Chin J Ophthalmol, 2020, 56: 0001). 2020-02-08
[Recommendations on extracorporeal life support for critically ill patients with novel coronavirus pneumonia]. Based on the clinical data of novel coronavirus pneumonia (NCP), as well as the dada from previous clinical studies and the recommendations from the Extracorporeal Life Support Organization (ELSO), the committee board of the Chinese Society of Extracorporeal Life Support (CSECLS) made this recommendations to guide clinical ECMO application in the patients with NCP. 2020-02-09
Clinical characteristics and therapeutic procedure for four cases with 2019 novel coronavirus pneumonia receiving combined Chinese and Western medicine treatment. We report here the clinical characteristics and therapeutic procedure for four patients with mild or severe 2019-nCoV pneumonia admitted to Shanghai Public Health Clinical Center. […] After treatment, three patients gained significant improvement in pneumonia associated symptoms, two of whom were confirmed 2019-nCoV negative and discharged, and one of whom was virus negative at the first test. 2020-03-18
Clinical characteristics of novel coronavirus cases in tertiary hospitals in Hubei Province. This study aims to investigate its epidemiologic history, and analyze the clinical characteristics, treatment regimens, and prognosis of patients infected with 2019-nCoV during this outbreak. […] Clinical data from 137 2019-nCoV-infected patients admitted to the respiratory departments of the respiratory departments of nine tertiary hospitals in Hubei province from December 30, 2019 to January 24, 2020 were retrospectively collected, including general status, clinical manifestations, laboratory test results, imaging characteristics, and treatment regimens. […] Major initial symptoms included fever (112/137, 81.8%), coughing (66/137, 48.2%), and muscle pain or fatigue (44/137, 32.1%), with other, less typical initial symptoms observed at low frequency, including heart palpitations, diarrhea, and headache. […] The risk of death was primarily associated with age, underlying chronic diseases, and median interval from the appearance of initial symptoms to dyspnea. 2020-03-02
Estimation of the Transmission Risk of the 2019-nCoV and Its Implication for Public Health Interventions. A deterministic compartmental model was devised based on the clinical progression of the disease, epidemiological status of the individuals, and intervention measures. 2020-03-20
Clinical and biochemical indexes from 2019-nCoV infected patients linked to viral loads and lung injury. Here we report the epidemiological, clinical, laboratory, and radiological characteristics, as well as potential biomarkers for predicting disease severity in 2019-nCoV-infected patients in Shenzhen, China. 2020-03-19
Preliminary prediction of the basic reproduction number of the Wuhan novel coronavirus 2019-nCoV. Based on the susceptible-exposed-infected-removed (SEIR) compartment model and the assumption that the infectious cases with symptoms occurred before 26 January, 2020 are resulted from free propagation without intervention, we estimate the basic reproduction number of 2019-nCoV according to the reported confirmed cases and suspected cases, as well as the theoretical estimated number of infected cases by other research teams, together with some epidemiological determinants learned from the severe acute respiratory syndrome (SARS). 2020-03-16
Chest CT for Typical 2019-nCoV Pneumonia: Relationship to Negative RT-PCR Testing. A combination of repeated swab tests and CT scanning may be helpful when for individuals with high clinical suspicion of nCoV infection but negative RT-PCR screening. 2020-02-12
Overview of The 2019 Novel Coronavirus (2019-nCoV): The Pathogen of Severe Specific Contagious Pneumonia (SSCP). To promptly identify patients and prevent further spreading, physicians should be aware of travel or contact history for patients with compatible symptoms. 2020-02-12
Potential Maternal and Infant Outcomes from (Wuhan) Coronavirus 2019-nCoV Infecting Pregnant Women: Lessons from SARS, MERS, and Other Human Coronavirus Infections. In order to assess the potential of the Wuhan 2019-nCoV to cause maternal, fetal and neonatal morbidity and other poor obstetrical outcomes, this communication reviews the published data addressing the epidemiological and clinical effects of SARS, MERS, and other coronavirus infections on pregnant women and their infants. […] Recommendations are also made for the consideration of pregnant women in the design, clinical trials, and implementation of future 2019-nCoV vaccines. 2020-03-23
[Recommendation for the diagnosis and treatment of novel coronavirus infection in children in Hubei (Trial version 1)]. In order to further standardize and enhance the clinical management of 2019-nCoV infection in children, reduce the incidence, and decrease the number of severe cases, we have formulated this diagnosis and treatment recommendation according to the recent information at home and abroad. 2020-02-19
Time Course of Lung Changes On Chest CT During Recovery From 2019 Novel Coronavirus (COVID-19) Pneumonia. Maximum lung involved peaked at approximately 10 days (with the calculated total CT score of 6) from the onset of initial symptoms (R2=0.25), p<0.001). […] Conclusion In patients recovering from COVID-19 pneumonia (without severe respiratory distress during the disease course), lung abnormalities on chest CT showed greatest severity approximately 10 days after initial onset of symptoms. 2020-02-13
Persons Evaluated for 2019 Novel Coronavirus - United States, January 2020. As of January 31, 2020, CDC had responded to clinical inquiries from public health officials and health care providers to assist in evaluating approximately 650 persons thought to be at risk for 2019-nCoV infection. 2020-02-18
Prophylactic and therapeutic remdesivir (GS-5734) treatment in the rhesus macaque model of MERS-CoV infection. Prophylactic remdesivir treatment initiated 24 h prior to inoculation completely prevented MERS-CoV-induced clinical disease, strongly inhibited MERS-CoV replication in respiratory tissues, and prevented the formation of lung lesions. […] Therapeutic remdesivir treatment initiated 12 h postinoculation also provided a clear clinical benefit, with a reduction in clinical signs, reduced virus replication in the lungs, and decreased presence and severity of lung lesions. […] The data presented here support testing of the efficacy of remdesivir treatment in the context of a MERS clinical trial. 2020-04-01
Case of the Index Patient Who Caused Tertiary Transmission of COVID-19 Infection in Korea: the Application of Lopinavir/Ritonavir for the Treatment of COVID-19 Infected Pneumonia Monitored by Quantitative RT-PCR. He is a worker for a clothing business and had mild respiratory symptoms and intermittent fever in the beginning of hospitalization, and pneumonia symptoms on chest computerized tomography scan on day 6 of admission. […] Hereby, we report the clinical findings of the index patient who was the first to cause tertiary transmission outside China. 2020-03-16
[Recommendations for general surgery clinical practice in novel coronavirus pneumonia situation]. Novel coronavirus pneumonia (NCP) is a highly infectious disease, has a long incubation period and a variety of clinical manifestations, which has a significant impact on public health and life. […] In order to implement the central government’s decision-making deployment and defeat the NCP as soon as possible, we had focused on the key points in the clinical work of general surgery according to latest relevant guidelines, literature and experience in epidemic prevention. 2020-02-14
Recombinant infectious bronchitis coronavirus H120 with the spike protein S1 gene of the nephropathogenic IBYZ strain remains attenuated but induces protective immunity. Like the rH120-infected group and in contrast to the rIBYZ-infected group, no mortality, clinical signs, or lesions were observed in the lungs or kidneys of young chickens inoculated with rH120-S1/YZ. 2020-02-15
[Clinical features of 2019 novel coronavirus pneumonia in the early stage from a fever clinic in Beijing]. Objective: To summarize and analyze the clinical and imaging characteristics of patients with 2019 novel coronavirus pneumonia in the early stage in Beijing. Methods: A retrospective analysis of clinical and imaging data of 9 patients with 2019 novel coronavirus infection diagnosed in one fever clinicic in Beijing from January 18, 2020 to February 3, 2020. Results: 5 male and 4 female was included in those 9 patients, whose median age was 36 years, and the age range from 15 to 49 years. 8 of these patients had no underlying disease and one suffered from diabetes. 7 patients had a history of travel to Wuhan City or Hubei Province, and one patient was a medical staff. […] The clinical manifestations were fever in 8 cases (8/9) , dry cough in 5 cases (5/9) , pharyngalgia in 4 cases (4/9) , fatigue in 4 cases (4/9) , body soreness in 4 cases (4/9) , and blocked or watery nose in 1 case (1/9) . […] The clinical manifestations are fever and cough. 2020-02-15
[Inhibitors of RAS Might Be a Good Choice for the Therapy of COVID-19 Pneumonia]. Animal studies have shown that RAS inhibitors could effectively relieve symptoms of acute severe pneumonia and respiratory failure. 2020-02-15
[Analysis of CT features of 15 Children with 2019 novel coronavirus infection]. Objective: To explore imaging characteristics of children with 2019 novel coronavirus (2019-nCoV) infection. Methods: A retrospective analysis was performed on clinical data and chest CT images of 15 children diagnosed with 2019-nCoV. […] The clinical symptoms of children with 2019-nCoV infection are nonspecific. 2020-02-16
[Retracted: Clinical and epidemiological characteristics of 34 children with 2019 novel coronavirus infection in Shenzhen]. Objective: To describe the characteristics of clinical manifestations and epidemiology of children with 2019 novel coronavirus (2019-nCoV) infection. Methods: All 34 children with laboratory-confirmed 2019-nCoV infection by quantitative real-time reverse transcription-PCR through nasopharyngeal swab specimens were admitted to the Third People’s Hospital of Shenzhen from January 19 to Febuary 7, 2020. […] Clinical data and epidemiological history of these patients were retrospectively collected and analyzed. Results: Among the 34 cases, 14 were males, and 20 were females. […] These patients could be categorized into different clinical types, including 22 (65%) common cases, 9 (26%) mild cases and 3 (8.8%) asymptomatic cases. […] The most common symptoms were fever (17 cases, 50%) and cough (13 cases, 38% ). […] Further following up was need. Conclusions: The clinical manifestations in children with 2019-nCoV infection are non-specific and are milder than that in adults. 2020-02-26
[Clinical characteristics of 30 medical workers infected with new coronavirus pneumonia]. Objective: To investigate the clinical characteristics of medical staff with novel coronavirus pneumonia(NCP). Methods: 30 patients infected with novel coronavirus referred to jianghan university hospital between January 11, 2020 and January 3, 2020 were studied. […] The data reviewed included those of clinical manifestations, laboratory investigation and Radiographic features. Results: The patients consisted of 10 men and 20 women, including 22 doctors and 8 nurses,aged 21~59 years(mean 35±8 years). […] The average contact times were 12 (7,16) and the average cumulative contact time was 2 (1.5,2.7) h.Clinical symptoms of these patients were fever in 23 patients (76.67%) , headache in 16 petients (53.33%) , fatigue or myalgia in 21patients (70%) , nausea, vomiting or diarrhea in 9 petients (30%) , cough in 25 petients (83.33%) , and dyspnea in 14 petients (46.67%) . 2020-02-17
[The epidemiological characteristics of an outbreak of 2019 novel coronavirus diseases (COVID-19) in China]. Analyses included: 1) summary of patient characteristics; 2) examination of age distributions and sex ratios; 3) calculation of case fatality and mortality rates; 4) geo-temporal analysis of viral spread; 5) epidemiological curve construction; and 6) subgroup analysis. Results: A total of 72 314 patient records-44 672 (61.8%) confirmed cases, 16 186 (22.4%) suspected cases, 10567 (14.6%) clinical diagnosed cases (Hubei only), and 889 asymptomatic cases (1.2%)-contributed data for the analysis. […] The epidemic curve of onset of symptoms peaked in January 23-26, then began to decline leading up to February 11. 2020-02-17
[The network investigation on knowledge, attitude and practice about Novel coronavirus pneumonia of the residents in Anhui Province]. Residents have a high awareness rate of the main symptoms, transmission routes, using of masks, hand washing and treatment information of NCP, while a low awareness rate of the atypical symptoms. 2020-02-17
[Analysis of the first cluster of cases in a family of novel coronavirus pneumonia in Gansu Province]. The epidemiological history and clinical characteristics of 7 cases of COVID-19 and 1 case of close contact in the first family aggregation epidemic of COVID-19 in Gansu Province were analyzed. 2020-02-17
Can Chinese Medicine Be Used for Prevention of Corona Virus Disease 2019 (COVID-19)? A Review of Historical Classics, Research Evidence and Current Prevention Programs. Historical records on prevention and treatment of infections in CM classics, clinical evidence of CM on the prevention of severe acute respiratory syndrome (SARS) and H1N1 influenza, and CM prevention programs issued by health authorities in China since the COVID-19 outbreak were retrieved from different databases and websites till 12 February, 2020. […] Research evidence included data from clinical trials, cohort or other population studies using CM for preventing contagious respiratory virus diseases. 2020-04-03
A familial cluster of infection associated with the 2019 novel coronavirus indicating potential person-to-person transmission during the incubation period. We report the epidemiological features of a familial cluster of four patients in Shanghai, of which one was 88 years old man with moving difficulties and was only exposed to his asymptomatic family members who developed symptoms later. 2020-04-03
2019 Novel coronavirus: where we are and what we know. This paper aggregates and consolidates the virology, epidemiology, clinical management strategies from both English and Chinese literature, official news channels, and other official government documents. 2020-04-02
[Health protection guideline of mobile cabin hospitals during Novel Coronavirus Pneumonia (NPC) outbreak]. This guideline is applicable to the health protection requirements of large indoor stadiums which are reconstructed as treatment sites for the Novel Coronavirus Pneumonia (NPC) patients with mild symptoms during the outbreak. 2020-02-19
Breakthrough: Chloroquine phosphate has shown apparent efficacy in treatment of COVID-19 associated pneumonia in clinical studies. Chloroquine phosphate, an old drug for treatment of malaria, is shown to have apparent efficacy and acceptable safety against COVID-19 associated pneumonia in multicenter clinical trials conducted in China. 2020-03-18
[Treatment strategy for gastrointestinal tumor under the outbreak of novel coronavirus pneumonia in China]. As surgeons specialized in the treatment of gastrointestinal tumors, we should always be aware of the prevention for NCP and incorporate this awareness into every detail of clinical practice. […] Gastric or esophagogastricjunction (EGJ) malignant tumor with obstruction can be managed with gastric tube decompression or stent placement to relieve the symptoms. 2020-03-12
[Novel coronavirus pneumonia related liver injury: etiological analysis and treatment strategy]. Here we analyzed the clinical features, susceptible population, potential causes and therapeutic strategies of NCP related liver injury. 2020-02-20
Clinical findings in a group of patients infected with the 2019 novel coronavirus (SARS-Cov-2) outside of Wuhan, China: retrospective case series. To study the clinical characteristics of patients in Zhejiang province, China, infected with the 2019 severe acute respiratory syndrome coronavirus 2 (SARS-Cov-2) responsible for coronavirus disease 2019 (covid-2019). […] Clinical data, collected using a standardised case report form, such as temperature, history of exposure, incubation period. […] The most common symptoms at onset of illness were fever in 48 (77%) patients, cough in 50 (81%), expectoration in 35 (56%), headache in 21 (34%), myalgia or fatigue in 32 (52%), diarrhoea in 3 (8%), and haemoptysis in 2 (3%). […] The median time from exposure to onset of illness was 4 days (interquartile range 3-5 days), and from onset of symptoms to first hospital admission was 2 (1-4) days. […] As of early February 2020, compared with patients initially infected with SARS-Cov-2 in Wuhan, the symptoms of patients in Zhejiang province are relatively mild. 2020-02-28
Clinical characteristics of 140 patients infected with SARS-CoV-2 in Wuhan, China. We aim to investigate the clinical characteristic and allergy status of patients infected with SARS-CoV-2. […] Electronic medical records including demographics, clinical manifestation, comorbidities, laboratory data, and radiological materials of 140 hospitalized COVID-19 patients, with confirmed result of SARS-CoV-2 viral infection, were extracted and analyzed. […] Fever (91.7%), cough (75.0%), fatigue (75.0%), and gastrointestinal symptoms (39.6%) were the most common clinical manifestations, whereas hypertension (30.0%) and diabetes mellitus (12.1%) were the most common comorbidities. […] Detailed clinical investigation of 140 hospitalized COVID-19 cases suggests eosinopenia together with lymphopenia may be a potential indicator for diagnosis. 2020-02-27
[Clinical Management of Lung Cancer Patients during the Outbreak of 2019 Novel Coronavirus Disease (COVID-19)]. With the spread of COVID-19, the routine clinical diagnosis and treatment for lung cancer patients has been disturbed. […] During the COVID-19 outbreak period, it should be carefully differentiated for fever and respiratory symptoms for lung cancer patients receiving anti-tumor treatment, in order to evaluate the risk of COVID-19. […] Moreover, it is necessary to carry out meticulous and individualized clinical management for lung cancer patients to effectively protect the patients from COVID-19. 2020-03-16
[Preliminary study of the relationship between novel coronavirus pneumonia and liver function damage: a multicenter study]. Objective: To analyze the clinical characteristics of cases of novel coronavirus pneumonia and a preliminary study to explore the relationship between different clinical classification and liver damage. Methods: Consecutively confirmed novel coronavirus infection cases admitted to seven designated hospitals during January 23, 2020 to February 8, 2020 were included. […] Clinical classification (mild, moderate, severe, and critical) was carried out according to the diagnosis and treatment program of novel coronavirus pneumonia (Trial Fifth Edition) issued by the National Health Commission. 2020-02-20
[Management strategy of Novel coronavirus pneumonia in burn and wound care ward]. In this paper, combining with the key clinical problems of prevention and control in hospital during the epidemic period of NCP infection, medical evidence, and clinical and management experience, the author formulates prevention and control management strategy of the author’s unit in order to provide reference for prevention and control of burn and wound care ward. 2020-02-20
Chest CT Findings in Coronavirus Disease-19 (COVID-19): Relationship to Duration of Infection. With a longer time after the onset of symptoms, CT findings were more frequent, including consolidation, bilateral and peripheral disease, greater total lung involvement, linear opacities, “crazy-paving” pattern and the “reverse halo” sign. 2020-02-20
2019 novel coronavirus of pneumonia in Wuhan, China: emerging attack and management strategies. More comprehensive information is required to understand 2019-nCoV feature, the epidemiology of origin and spreading, and the clinical phenomina. 2020-03-06
Viral Load Kinetics of SARS-CoV-2 Infection in First Two Patients in Korea. With the numbers of confirmed cases are increasing, information on the epidemiologic investigation and clinical manifestation have been accumulated. 2020-03-16
[Emergency management of prevention and control of novel coronavirus pneumonia in departments of stomatology]. Complying with overall requirements of the government and regulations on public health emergences, as well as the clinical features of diagnosis and treatment of dental illness, this paper refers to previous guidelines and studies on the infection prevention and control in dental diagnosis and treatment in China and foreign countries. 2020-02-21
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and coronavirus disease-2019 (COVID-19): The epidemic and the challenges. The one case of SARS-CoV-2 pneumonia in the USA is responding well to remdesivir, which is now undergoing a clinical trial in China. 2020-03-25
COVID-2019: The role of the nsp2 and nsp3 in its pathogenesis. The positive selective pressure could account for some clinical features of this virus compared with severe acute respiratory syndrome (SARS) and Bat SARS-like CoV. 2020-02-28
Coronavirus Disease 2019 (COVID-19): A Perspective from China. To date, CT findings have been recommended as major evidence for clinical diagnosis of COVID-19 in Hubei, China. […] This review focuses on the etiology, epidemiology, and clinical symptoms of COVID-19, while highlighting the role of chest CT in prevention and disease control. A full translation of this article in Chinese is available. 2020-02-21
[Standardized diagnosis and treatment of colorectal cancer during the outbreak of novel coronavirus pneumonia in Renji hospital]. Although colorectal surgery is not a front-line subject in the fight against the epidemic, but in this special situation, now it is a difficult task that with the premise of how to maximize the protection for patients and their families, health of medical staff, and the safety of wards and hospitals, we can provide the highest quality medical services to ensure the orderly development of previous clinical work. […] Referring to the “Diagnosis and Treatment Scheme for NCP (Trial Version 4 and 5)” and combining the actual practice situation in our hospital with the “Summary of New Coronavirus Files of Shanghai Renji Hospital”, we summarize how to carry out the clinical practice of colorectal surgery under the situation of the prevention and control of the NCP epidemiology, meanwhile under such situation aiming the procedure of diagnose and treatment for emergency patients with colorectal tumor, we share the experiences of the diagnosis of colorectal tumor, the management of patients with colorectal cancer who are scheduled to be admitted for surgery, the protection of wards, the perioperative management. 2020-02-22
[Psychological intervention in oral patients in novel coronavirus pneumonia outbreak period]. At the same time, this paper analyzes the possible psychological stress symptoms of patients with different oral diseases, and puts forward suggestions for remote consultation and emergency treatment of dentists. 2020-02-22
The SARS, MERS and novel coronavirus (COVID-19) epidemics, the newest and biggest global health threats: what lessons have we learned? Utilizing the Centers for Disease Control and Prevention (CDC, USA) website, and a comprehensive review of PubMed literature, we obtained information regarding clinical signs and symptoms, treatment and diagnosis, transmission methods, protection methods and risk factors for Middle East Respiratory Syndrome (MERS), Severe Acute Respiratory Syndrome (SARS) and COVID-19. 2020-02-22
[The keypoints in treatment of the critical novel coronavirus pneumonia patient]. In addition, there is up regulation of inflammatory factors in patients with severe NCP, but the effect of renal replacement therapy needs to be further confirmed by clinical research. 2020-02-23
[Comparison of the clinical characteristics between RNA positive and negative patients clinically diagnosed with 2019 novel coronavirus pneumonia]. Objective: To raise awareness about 2019 novel coronavirus pneumonia (NCP) and reduce missed diagnosis rate and misdiagnosis rate by comparing the clinical characteristics between RNA positive and negative patients clinically diagnosed with NCP. Methods: From January 2020 to February 2020, 54 patients who were newly diagnosed with NCP in Wuhan Fourth Hospital were included in this study. […] The patients were divided into RNA positive and negative group, and the differences of clinical, laboratory, and radiological characteristics were compared. Results: There were 31 RNA of 2019-nCov positive cases, and 23 negative cases. […] Common clinical symptoms of two groups were fever (80.64% vs. 86.96%) , chills (61.29% vs.52.17%) , cough (80.64% vs.95.65%) , fatigue (61.30% vs.56.52%) , chest distress (77.42% vs.73.91%) . […] Some other symptoms were headache, myalgia, dyspnea, diarrhea, nausea and vomiting. […] There was no statistically significant difference in other clinical characteristics except for dyspnea between two groups. Conclusions: RNA positive and negative NCP patients shared similar clinical symptoms, while RNA positive NCP patients tended to have dyspnea. 2020-02-23
2019-nCoV (Wuhan virus), a novel Coronavirus: human-to-human transmission, travel-related cases, and vaccine readiness. The first patients began experiencing symptoms of illness in mid-December 2019. […] Clinical isolates were found to contain a novel coronavirus with similarity to bat coronaviruses. […] There are several critical clinical questions that need to be resolved, including how efficient is human-to-human transmission? 2020-03-18
18F-FDG PET/CT findings of COVID-19: a series of four highly suspected cases. We describe the 18F-FDG PET/CT results from four patients who were admitted to the hospital with respiratory symptoms and fever between January 13 and January 20, 2020, when the COVID-19 outbreak was still unrecognized and the virus infectivity was unknown. […] A retrospective review of the patients’ medical history, clinical and laboratory data, as well as imaging findings strongly suggested a diagnosis of COVID-19. […] Although 18F-FDG PET/CT cannot be routinely used in an emergency setting and is generally not recommended for infectious diseases, our pilot data shed light on the potential clinical utility of this imaging technique in the differential diagnosis of complex cases. 2020-04-03
Estimated effectiveness of symptom and risk screening to prevent the spread of COVID-19. Breaking down the factors leading to screening successes and failures, we find that most cases missed by screening are fundamentally undetectable, because they have not yet developed symptoms and are unaware they were exposed. 2020-03-18
Chest CT Findings in Patients With Coronavirus Disease 2019 and Its Relationship With Clinical Features. The aim of this study was to investigate the chest computed tomography (CT) findings in patients with confirmed coronavirus disease 2019 (COVID-19) and to evaluate its relationship with clinical features. […] The chest CT images and clinical data were reviewed, and the relationship between them was analyzed. […] With regards to the clinical manifestations, 58 (73%) of the 80 patients had cough, and 61 (76%) of the 80 patients had high temperature levels. […] There are significant correlations between the degree of pulmonary inflammation and the main clinical symptoms and laboratory results. 2020-04-14
COVID-19: Real-time dissemination of scientific information to fight a public health emergency of international concern. This issue has rapidly reviewed and published articles describing COVID-19, including the drug treatment options for SARS-CoV-2, its clinical characteristics, and therapies involving a combination of Chinese and Western medicine, the efficacy of chloroquine phosphate in the treatment of COVID-19 associated pneumonia according to clinical studies, and reflections on the system of reserve medical supplies for public health emergencies. […] As an academic journal, we will continue to quickly and transparently share data with frontline healthcare workers who need to know the epidemiological and clinical features of COVID-19. 2020-03-18
High expression of ACE2 receptor of 2019-nCoV on the epithelial cells of oral mucosa. Preliminarily, those findings have explained the basic mechanism that the oral cavity is a potentially high risk for 2019-nCoV infectious susceptibility and provided a piece of evidence for the future prevention strategy in dental clinical practice as well as daily life. 2020-03-18
[Dynamic changes of chest CT imaging in patients with corona virus disease-19 (COVID-19)]. The chest CT images of patients with COVID-19 have certain characteristics with dynamic changes, which are of value for monitoring disease progress and clinical treatment. 2020-03-16
[Management of corona virus disease-19 (COVID-19): the Zhejiang experience]. As the National Clinical Research Center for Infectious Diseases, the First Affiliated Hospital of Zhejiang University School of Medicine is the primary medical care center for COVID-19 inZhejiang Province. […] Based on the present expert consensus carried out by National Health Commission and National Administration of Traditional Chinese Medicine, our team summarized and established an effective treatment strategy centered on “Four-Anti and Two-Balance” for clinical practice. […] The importance of early viralogical detection, dynamic monitoring of inflammatory indexes and chest radiograph was emphasized in clinical decision-making. 2020-03-16
[The treatment proposal for the patients with breast diseases in the central epidemic area of 2019 coronavirus disease]. The characteristics including high contagiousness, herd susceptibility and clinical phenotype diversity, made a serious influence on people’s daily life and rountine therapy for other diseases. […] Breast dieases are clinical common diseases. […] In the central epidemic area of COVID-19, Hubei province, especially Wuhan, the clinical specialists of breast diseases should consider all of the following factors comprehensively: the prevention of COVID-19, the diagnosis and treatment of breast diseases and the accessibility of medical resources. […] Therefore, we carried out some management proposals of the patients with breast diseases in the central epidemic area during the epidemic of COVID-19 on the basis of conventional treatment guidelines and clinical experiences. 2020-02-25
Systematic Comparison of Two Animal-to-Human Transmitted Human Coronaviruses: SARS-CoV-2 and SARS-CoV. After the outbreak of the severe acute respiratory syndrome (SARS) in the world in 2003, human coronaviruses (HCoVs) have been reported as pathogens that cause severe symptoms in respiratory tract infections. […] This virus causes acute lung symptoms, leading to a condition that has been named as “coronavirus disease 2019” (COVID-19). […] There are some similarities and differences in the epidemiology and clinical features between these two viruses and diseases that are caused by these viruses. 2020-03-23
An updated estimation of the risk of transmission of the novel coronavirus (2019-nCov). Due to significant variations in the control strategies, which have been changing over time, and thanks to the introduction of detection technologies that have been rapidly improved, enabling to shorten the time from infection/symptoms onset to diagnosis, leading to faster confirmation of the new coronavirus cases, our previous estimations on the transmission risk of the 2019-nCoV need to be revised. 2020-04-01
2019 Novel Coronavirus (COVID-19) Pneumonia: Serial Computed Tomography Findings. In this study, we present serial CT findings in a 40-year-old female patient with COVID-19 pneumonia who presented with the symptoms of fever, chest tightness, and fatigue. 2020-03-24
[Airway management of COVID-19 patients with severe pneumonia]. Noninvasive or invasive positive pressure ventilation will be important means for those patients, which will help to improve the clinical cure rate and reduce the mortality. 2020-02-26
[Chemotherapy strategy for colorectal cancer under the outbreak of novel coronavirus pneumonia]. Clinicians should make individual clinical decisions based on the specifics of each patient durding epidemic situation. 2020-02-26
Detectable 2019-nCoV viral RNA in blood is a strong indicator for the further clinical severity. The novel coronavirus (2019-nCoV) infection caused pneumonia. we retrospectively analyzed the virus presence in the pharyngeal swab, blood, and the anal swab detected by real-time PCR in the clinical lab. […] Meanwhile, 8 of the 11 patients with annal swab virus-positive was in severe clinical stage. 2020-03-19
Expert Recommendations for Tracheal Intubation in Critically ill Patients with Noval Coronavirus Disease 2019. Most of the infected patients have mild symptoms including fever, fatigue and cough. 2020-02-27
The neuroinvasive potential of SARS-CoV2 may play a role in the respiratory failure of COVID-19 patients. This virus shares highly homological sequence with SARS-CoV, and causes acute, highly lethal pneumonia coronavirus disease 2019 (COVID-19) with clinical symptoms similar to those reported for SARS-CoV and MERS-CoV. 2020-03-18
Development and clinical application of a rapid IgM-IgG combined antibody test for SARS-CoV-2 infection diagnosis. With this test kit, we carried out clinical studies to validate its clinical efficacy uses. […] The clinical detection sensitivity and specificity of this test were measured using blood samples collected from 397 PCR confirmed COVID-19 patients and 128 negative patients at eight different clinical sites. […] In addition, we evaluated clinical diagnosis results obtained from different types of venous and fingerstick blood samples. 2020-04-13
Immune responses in COVID-19 and potential vaccines: Lessons learned from SARS and MERS epidemic. As the world is witnessing the epidemic of COVID-19, a disease caused by a novel coronavirus, SARS-CoV-2, emerging genetics and clinical evidences suggest a similar path to those of SARS and MERS. 2020-03-24
Clinical course and outcomes of critically ill patients with SARS-CoV-2 pneumonia in Wuhan, China: a single-centered, retrospective, observational study. We aimed to describe the clinical course and outcomes of critically ill patients with SARS-CoV-2 pneumonia. […] Demographic data, symptoms, laboratory values, comorbidities, treatments, and clinical outcomes were all collected. 2020-04-01
Radiological findings from 81 patients with COVID-19 pneumonia in Wuhan, China: a descriptive study. Patients were grouped on the basis of the interval between symptom onset and the first CT scan: group 1 (subclinical patients; scans done before symptom onset), group 2 (scans done ≤1 week after symptom onset), group 3 (>1 week to 2 weeks), and group 4 (>2 weeks to 3 weeks). […] Combining assessment of imaging features with clinical and laboratory findings could facilitate early diagnosis of COVID-19 pneumonia. 2020-04-08
Coronavirus Disease 2019 (COVID-19) and pregnancy: what obstetricians need to know. In 2 reports describing 18 pregnancies with coronavirus disease 2019, all were infected in the third trimester, and clinical findings were similar to those in nonpregnant adults. 2020-04-15
Imaging and clinical features of patients with 2019 novel coronavirus SARS-CoV-2. We aimed to report the imaging and clinical characteristics of these patients infected with SARS-CoV-2 in Guangzhou, China. […] We analyzed the clinical characteristics of the patients, as well as the distribution characteristics, pattern, morphology, and accompanying manifestations of lung lesions. […] SARS-CoV-2 infection can be confirmed based on the patient’s history, clinical manifestations, imaging characteristics, and laboratory tests. 2020-04-03
[Treatment of pancreatic diseases and prevention of infection during outbreak of 2019 coronavirus disease]. Objective: To explorethe proper protective measures for pancreaticdiseases treatment during theoutbreak of 2019 coronavirus disease(COVID-19). Method: Clinical data of four cases of patients that suffered COVID-19from February 2(nd), 2020 to February 9(th), 2020 in pancreatic surgery were reviewed.After the first patientscuffednosocomial infection of COVID-19, the general protective measures in our department wereupdated.Only one patient was admitted to each room alone, with no more than one caregiver.The body temperature of care givers was measuredtwice a day.Primary protections were applied to all staff.The floor was sterilized using disinfectant with an effective chlorine concentration of 1000 mg/L.The protective measures for interventional procedures were as follow.Primary protection was applied to the operators ofcentral venipuncture catheter, percutaneous abdominal/pleural drainage, percutaneous retroperitoneal drainage, percutaneous transhepatic cholangial drainage and other surgical procedures with local anesthesiaand epidural anesthesia.Secondary protection was applied to the operators of endoscopic retrograde cholangiopancreatography and surgical procedures with general anesthesia. Results: During Feb 2(nd), 2020 to Feb 9(th), 2020, four patients in our department were diagnosed with COVID-19, of which one was died of COVID-19, two were cured, and one is still in hospital for COVID-19. 2020-02-28
Clinical characteristics of hospitalized patients with SARS-CoV-2 infection: A single arm meta-analysis. We aim to summarize reliable evidence of evidence-based medicine for the treatment and prevention of the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) by analyzing all the published studies on the clinical characteristics of patients with SARS-CoV-2. […] Several studies on the clinical characteristics of SARS-CoV-2 infection were collected for meta-analysis. […] Fever and cough are the most common symptoms in patients with SARS-CoV-2 infection, and most of these patients have abnormal chest CT examination. […] Diarrhea, hemoptysis, headache, sore throat, shock, and other symptoms are rare. 2020-03-18
Clinical trial analysis of 2019-nCoV therapy registered in China. With more and more patients diagnosed, China has carried out more than 100 clinical studies of new coronavirus infection, including antiviral drugs, antimalarial drugs, glucocorticoids, plasma therapy, virus vaccine, and other Western drugs, while Chinese medicine research accounted for half of the studies. […] Compared with that of during SARS period in 2003, China has the stronger capability to carry out clinical trials of new drugs in emergency period. 2020-03-05
Clinical Characteristics of Coronavirus Disease 2019 in China. Since December 2019, when coronavirus disease 2019 (Covid-19) emerged in Wuhan city and rapidly spread throughout China, data have been needed on the clinical characteristics of the affected patients. […] The most common symptoms were fever (43.8% on admission and 88.7% during hospitalization) and cough (67.8%). 2020-04-07
Clinical Characteristics of Imported Cases of COVID-19 in Jiangsu Province: A Multicenter Descriptive Study. We aimed to report the clinical characteristics of imported coronavirus disease-19 (COVID-19) in Jiangsu Province. […] We retrospectively investigated the clinical, imaging, and laboratory characteristics of confirmed cases of COVID-19 with WHO interim guidance in three Grade ⅢA hospitals of Jiangsu from Jan 22 to Feb 14, 2020. […] Except for 3 severe patients, the rest of the 77 patients exhibited mild or moderate symptoms. 9 patients were unconfirmed until a third-time nucleic acid test. 38 cases had a history of chronic diseases. […] The main clinical manifestations of the patients were fever and cough, which accounted for 63 cases (78.75%) and 51 cases (-63.75%) respectively. […] Compared with the cases in Wuhan, the cases in Jiangsu exhibited mild or moderate symptoms and no obvious gender susceptivity. 2020-04-03
Clinical and computed tomographic imaging features of novel coronavirus pneumonia caused by SARS-CoV-2. To investigate the clinical and imaging characteristics of computed tomography (CT) in novel coronavirus pneumonia (NCP) caused by SARS-CoV-2. […] The clinical and imaging data were analyzed. 2020-04-06
Coronavirus 2019-nCoV: A brief perspective from the front line. Therefore, it is critical to understand the nature of the virus and its clinical characteristics, in order to respond to the 2019-nCoV outbreak. 2020-04-06
Potential Rapid Diagnostics, Vaccine and Therapeutics for 2019 Novel Coronavirus (2019-nCoV): A Systematic Review. Some are being tested in clinical trials against MERS-CoV and SARS-CoV, while others have been listed for clinical trials against 2019-nCoV. 2020-04-11
2019 novel coronavirus disease (COVID-19) in Taiwan: Reports of two cases from Wuhan, China. The reported cases highlight non-specific clinical presentations of 2019 novel coronavirus disease (COVID-19) as well as the importance of rapid laboratory-based diagnosis. 2020-04-01
[Medical diagnosis and treatment strategies for malignant tumors of the digestive system during the outbreak of novel coronavirus pneumonia]. Combining the guidelines for diagnosis and treatment of tumors with our clinical experience, in this epidemic period, we discuss the strategies for diagnosis, treatment, and follow-up of malignant tumors of the digestive system in this article. 2020-02-29
The psychological impact of quarantine and how to reduce it: rapid review of the evidence. Most reviewed studies reported negative psychological effects including post-traumatic stress symptoms, confusion, and anger. 2020-03-26
Clinical characteristics and imaging manifestations of the 2019 novel coronavirus disease (COVID-19):A multi-center study in Wenzhou city, Zhejiang, China. The aim of this paper was to describe the clinical characteristics and imaging manifestations of hospitalized patients with confirmed COVID-19 infection in Wenzhou, Zhejiang, China. […] Fever, cough and expectoration were the most common symptoms, 14 patients had decreased oxygen saturation, 33 had leukopenia, 53 had lymphopenia, and 82 had elevated C-reactive protein. 2020-04-06
Characteristics of COVID-19 infection in Beijing. We analyzed the data of 262 confirmed cases to determine the clinical and epidemiological characteristics of COVID-19 in Beijing. […] The information on demographic, epidemiological, clinical, laboratory test for the COVID-19 virus, diagnostic classification, cluster case and outcome were obtained. […] The most common symptoms at the onset of illness were fever (82.1%), cough (45.8%), fatigue (26.3%), dyspnea (6.9%) and headache (6.5%). 2020-04-06
[Fitting and forecasting the trend of COVID-19 by SEIR(+ CAQ) dynamic model]. Regardless of the cases diagnosed by clinical examines, the numbers of daily emerging cases of China (Hubei province not included), Hubei Province (Wuhan city not included) and Wuhan city reached the peak in the early February. 2020-03-01
The epidemiology and pathogenesis of coronavirus disease (COVID-19) outbreak. In this review, we highlights the symptoms, epidemiology, transmission, pathogenesis, phylogenetic analysis and future directions to control the spread of this fatal disease. 2020-04-15
Pulmonary Pathology of Early-Phase 2019 Novel Coronavirus (COVID-19) Pneumonia in Two Patients With Lung Cancer. Because both patients did not exhibit symptoms of pneumonia at the time of operation, these changes likely represent an early phase of the lung pathology of COVID-19 pneumonia. 2020-04-09
Comparison of different samples for 2019 novel coronavirus detection by nucleic acid amplification tests. Here we report the epidemiological, clinical, laboratory and radiological characteristics of 19 suspect cases. 2020-04-13
[Pregnant women with new coronavirus infection: a clinical characteristics and placental pathological analysis of three cases]. Objective: To investigate the clinical characteristics and placental pathology of 2019-nCoV infection in pregnancy, and to evaluate intrauterine vertical transmission potential of 2019-nCoV infection. Methods: The placentas delivered from pregnant women with confirmed 2019-nCoV infection which were received in the Department of Pathology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology collected by February 4th, 2020 and retrospectively studied. […] Their clinical material including placental tissue and lung CT, and laboratory results were collected, meanwhile, nucleic acid detection of 2019-nCoV of the placentas were performed by RT-PCR. Results: Three placentas delivered from pregnant women with confirmed 2019-nCoV infection, who were all in their third trimester with emergency caesarean section. […] All samples from three placentas were negative for the nucleic acid of 2019-nCoV. Conclusions: The clinical characteristics of pregnant women with 2019-nCoV infection in late pregnancy are similar to those of non-pregnant patients, and no severe adverse pregnancy outcome is found in the 3 cases of our observation. 2020-03-02
A Chinese Case of COVID-19 Did Not Show Infectivity During the Incubation Period: Based on an Epidemiological Survey. Controversy remains over whether the novel coronavirus 2019 (COVID-19) virus may have infectivity during the incubation period before the onset of symptoms. 2020-04-14
Therapeutic strategies in an outbreak scenario to treat the novel coronavirus originating in Wuhan, China. The sequence of the ACE2-Fc protein is provided to investigators, allowing its possible use in recombinant protein expression systems to start producing drug today to treat patients under compassionate use, while formal clinical trials are later undertaken. 2020-03-20
[Clinical analysis of 31 cases of 2019 novel coronavirus infection in children from six provinces (autonomous region) of northern China]. Objective: To analyze the epidemiological history, clinical manifestations, treatment and the short-term prognosis of 31 cases of 2019 novel coronavirus(2019-nCoV) infection in children from six provinces (autonomous region) in northern China. Methods: A retrospective analysis of the epidemiological history, clinical symptoms, signs, laboratory examinations, chest imaging, treatment and the short-term prognosis of 31 cases of 2019-nCoV was conducted. […] The clinical types were asymptomatic type in 4 cases (13%), mild type in 13 cases (42%), and common type in 14 cases (45%). […] Other symptoms included cough (n=14, 45%), fatigue (n=3, 10%) and diarrhea (n=3, 9%). […] Clinical types are asymptomatic, mild and common types. […] Clinical manifestations and laboratory examination results are nonspecific. 2020-03-02
[Epidemiological characteristics of novel coronavirus pneumonia in Henan]. Among 605 patients, the symptoms were fever (553 cases, 91.4%) , debilitation (44 cases, 7.3%) , cough (110 cases, 18.2%) , expectoration (19 cases, 3.1%) , chills (6 cases, 1.0%) , shiver (7 cases, 1.2%) , running nose (21 cases, 3.5%) , stuffy noses (8 cases, 1.3%) , throat dryness and sore (24 cases, 4.0%) , headache (21 cases, 3.5%) , chest pain (6 cases, 1.0%) , anhelation (18 cases, 3.0%) , and gastrointestinal symptom (21 cases, 3.5%) . 2020-03-02
[Cause analysis and treatment strategies of “recurrence” with novel coronavirus pneumonia (covid-19) patients after discharge from hospital]. This might be due to the biological characteristics of 2019-nCoV, and might also be related to the basic disease, clinical status, glucocorticoid using, sample sampling, processing and detecting of patients, and some even related to the re-infection or secondary bacterial virus infection. 2020-03-02
[Diagnostic and therapeutic strategies of lung cancer patients during the outbreak of 2019 novel coronavirus disease (COVID-19)]. Lung cancer patients are difficult to differentiate from patients with COVID-19 in terms of clinical symptoms, which will bring great trouble to the clinical work and physical and mental health of lung cancer patients. 2020-03-02
COVID-19 in 2 Persons with Mild Upper Respiratory Symptoms on a Cruise Ship, Japan. We describe 2 cases of COVID-19 in patients with mild upper respiratory symptoms. […] One patient had persistent, low-grade upper respiratory tract symptoms without fever. 2020-03-02
The Clinical and Chest CT Features Associated with Severe and Critical COVID-19 Pneumonia. To investigate the clinical and CT features associated with severe and critical Corona Virus Disease 2019 (COVID-19) pneumonia. […] The chest CT images and clinical data of them were reviewed and compared. […] The clinical factors of age > 50 years old, comorbidities, dyspnea, chest pain, cough, expectoration, decreased lymphocytes and increased inflammation indicators were risk factors for severe/critical COVID-19 pneumonia. […] There are significant differences in clinical symptoms, laboratory examinations and CT manifestations between the ordinary patients and the severe/critical patients. 2020-03-02
Persistence and clearance of viral RNA in 2019 novel coronavirus disease rehabilitation patients. The clinical data and laboratory test results of convalescent patients with COVID-19 who were admitted to from January 20, 2020 to February 10, 2020 were collected retrospectively. […] Convalescent patients refer to recovered non-febrile patients without respiratory symptoms who had two successive (minimum 24 h sampling interval) negative RT-PCR results for viral RNA from oropharyngeal swabs. […] After in-hospital treatment, patients’ inflammatory indicators decreased with improved clinical condition. […] The median time from the onset of symptoms to first negative RT-PCR results for oropharyngeal swabs in convalescent patients was 9.5 (6.0-11.0) days. 2020-03-02
Analysis of factors associated with disease outcomes in hospitalized patients with 2019 novel coronavirus disease. Individual data, laboratory indices, imaging characteristics, and clinical data were collected, and statistical analysis was performed. […] Based on clinical typing results, the patients were divided into a progression group or an improvement/stabilization group. 2020-03-02
Feasibility of controlling COVID-19 outbreaks by isolation of cases and contacts. We considered scenarios that varied in the number of initial cases, the basic reproduction number (R0), the delay from symptom onset to isolation, the probability that contacts were traced, the proportion of transmission that occurred before symptom onset, and the proportion of subclinical infections. […] The probability of control decreases with long delays from symptom onset to isolation, fewer cases ascertained by contact tracing, and increasing transmission before symptoms. 2020-03-26
Asymptomatic novel coronavirus pneumonia patient outside Wuhan: The value of CT images in the course of the disease. The purpose of this case report is to describe the imaging and associated clinical features of an asymptomatic novel coronavirus pneumonia (COVID-19) patient outside Wuhan, China. […] The principle findings are that in this patient with laboratory-confirmed COVID-19, CT findings preceded symptoms and included bilateral pleural effusions, previously not reported in association with COVID-19. 2020-04-09
[Clinical characteristics and outcomes of 112 cardiovascular disease patients infected by 2019-nCoV]. Objective: To explore the clinical characteristics and prognosis of the new coronavirus 2019-nCoV patients combined with cardiovascular disease (CVD). Methods: A retrospective analysis was performed on 112 COVID-19 patients with CVD admitted to the western district of Union Hospital in Wuhan, from January 20, 2020 to February 15, 2020. […] They were divided into critical group (ICU, n=16) and general group (n=96) according to the severity of the disease and patients were followed up to the clinical endpoint. 2020-03-02
Stepping up infection control measures in ophthalmology during the novel coronavirus outbreak: an experience from Hong Kong. In order to minimise cross-infection of COVID-19, a triage system was set up to identify patients with fever, respiratory symptoms, acute conjunctivitis or recent travel to outbreak areas and to encourage these individuals to postpone their appointments for at least 14 days. […] All elective clinical services were suspended. […] Infection control training was provided to all clinical staff. […] All staff were advised to measure their own body temperatures before work and promptly report any symptoms of upper respiratory tract infection, vomiting or diarrhoea. […] In order to minimise transmission of COVID-19, ophthalmologists should work closely with local infection control teams to implement infection control measures that are appropriate for their own clinical settings. 2020-03-03
Fecal specimen diagnosis 2019 novel coronavirus-infected pneumonia. And we found that patients with a positive stool test did not experience gastrointestinal symptoms and had nothing to do with the severity of the lung infection. […] These results may help to understand the clinical diagnosis and the changes in clinical parameters of COVID-19. 2020-03-12
[Recommendations for respiratory rehabilitation of COVID-19 in adult]. COVID-19 is a highly infectious respiratory infection disease, which leads to dysfunction of respiratory, physical, and psychological of the patients. pulmonary rehabilitation is an important intervention for clinical patients as well as cure patients. […] With the deeper cognition of COVID-19 and accumulation of clinical experience, we proposed the recommendations for pulmonary rehabilitation of COVID-19 in adults based on the opinions of front-line clinical experts involved in the management of this epidemic and a review of the relevant literature and evidences: 1. for the inpatients with COVID-19, pulmonary rehabilitation would relieve the symptoms of dyspnea, anxiety, and depression; eventually improve physical function and the quality of life; 2. […] These recommendations can serve as a clinical practice guidence and basis for pulmonary rehabilitation of COVID-19. 2020-03-03
[Analysis on the epidemic factors for the Corona Virus Disease]. This puts a lot of pressure on clinical resources and care. […] These put a lot of pressure on clinical resources and care. 2020-03-03
[Expert recommendations on the management of patients with advanced non-small cell lung cancer during epidemic of COVID-19 (Trial version)]. During epidemic of COVID-19, a guideline for the optimal management of patients with advanced lung cancer urgently needs to be proposed to distinguish the symptoms of COVID-19 and the side effects of antitumor drugs. […] This network questionnaire survey was conducted on the lung cancer group of the Chinese Thoracic Society, Chinese Medical Association; the lung cancer group of the Chinese Society of Clinical Oncology Youth Committee; and the Chinese Respiratory Oncology Collaboration. 321 valid questionnaires were received. […] During the epidemic of COVID-19, We recommended that patients with advanced NSCLC should be treated as outpatients as possible at the nearest medical center; Patients who need to be hospitalized for antitumor treatment should be excluded from COVID-19 infection; More intensive attention should be paid to identification of COVID-19-related symptoms and adverse reactions caused by the malignancy or antitumor treatments. 2020-03-03
Broad Spectrum Antiviral Agent Niclosamide and Its Therapeutic Potential. In this brief review, we summarize the broad antiviral activity of niclosamide and highlight its potential clinical use in the treatment of COVID-19. 2020-04-09
Epidemiologic Features and Clinical Course of Patients Infected With SARS-CoV-2 in Singapore. To report the initial experience in Singapore with the epidemiologic investigation of this outbreak, clinical features, and management. […] Clinical, laboratory, and radiologic data were collected, including PCR cycle threshold values from nasopharyngeal swabs and viral shedding in blood, urine, and stool. […] Clinical course was summarized, including requirement for supplemental oxygen and intensive care and use of empirical treatment with lopinavir-ritonavir. […] Among the 18 hospitalized patients with PCR-confirmed SARS-CoV-2 infection (median age, 47 years; 9 [50%] women), clinical presentation was an upper respiratory tract infection in 12 (67%), and viral shedding from the nasopharynx was prolonged for 7 days or longer among 15 (83%). […] Among the first 18 patients diagnosed with SARS-CoV-2 infection in Singapore, clinical presentation was frequently a mild respiratory tract infection. […] Some patients required supplemental oxygen and had variable clinical outcomes following treatment with an antiretroviral agent. 2020-03-17
Understanding SARS-CoV-2-Mediated Inflammatory Responses: From Mechanisms to Potential Therapeutic Tools. In the absence of a proven clinical FcR blocker, the use of intravenous immunoglobulin to block FcR activation may be a viable option for the urgent treatment of pulmonary inflammation to prevent severe lung injury. 2020-03-03
Relation Between Chest CT Findings and Clinical Conditions of Coronavirus Disease (COVID-19) Pneumonia: A Multicenter Study. The purpose of this study was to investigate the relation between chest CT findings and the clinical conditions of COVID-19 pneumonia. MATERIALS AND METHODS. Data on 101 cases of COVID-19 pneumonia were retrospectively collected from four institutions in Hunan, China. […] Basic clinical characteristics and detailed imaging features were evaluated and compared between two groups on the basis of clinical status: nonemergency (mild or common disease) and emergency (severe or fatal disease). RESULTS. Patients 21-50 years old accounted for most (70.2%) of the cohort, and five (5.0%) patients had disease associated with a family outbreak. 2020-03-04
Differential diagnosis of illness in patients under investigation for the novel coronavirus (SARS-CoV-2), Italy, February 2020. Since the symptoms are similar to other respiratory infections, differential diagnosis in travellers arriving from countries with wide-spread COVID-19 must include other more common infections such as influenza and other respiratory tract diseases. 2020-03-18
Angiotensin receptor blockers as tentative SARS-CoV-2 therapeutics. This commentary elaborates on the idea of considering AT1R blockers as tentative treatment for SARS-CoV-2 infections, and proposes a research direction based on datamining of clinical patient records for assessing its feasibility. 2020-03-04
[Comparison of heart failure and 2019 novel coronavirus pneumonia in chest CT features and clinical characteristics]. Objective: To identify the characteristics including clinical features and pulmonary computed tomography (CT) features of heart failure and novel coronavirus pneumonia(COVID-19). Methods: This study was a retrospective study. […] The baseline clinical and imaging features of the two groups were statistically analyzed. Results: There was no significant difference in age and sex between the two groups, but the incidence of epidemiological contact history, fever or respiratory symptoms in the COVID-19 group was significantly higher than that in the heart failure group (12/12 vs. 2/7, P=0.001; 12/12 vs. 4/7, P<0.001). […] 2/7, P=0.048) . Conclusions: More patients with COVID-19 have epidemiological history and fever or respiratory symptoms. 2020-03-04
Genomic diversity of SARS-CoV-2 in Coronavirus Disease 2019 patients. Although how the intra-host variant spreads in the population is still elusive, it is necessary to strengthen the surveillance of the viral evolution in the population and associated clinical changes. 2020-04-03
Coronavirus Disease 2019 (COVID-19): Role of Chest CT in Diagnosis and Management. We reviewed the clinical information, CT images, and corresponding image reports of these 53 patients. 2020-03-04
[Mental health survey of 230 medical staff in a tertiary infectious disease hospital for COVID-19]. Objective: To investigate the mental health of clinical first-line medical staff in COVID-19 epidemic and provide theoretical basis for psychological intervention. Method: The mental health status of the first-line medical staff was investigated by Self-rating Anxiety Acale (SAS) and Post-Traumatic Stress Disorder Self-rating Scale(PTSD-SS). 2020-03-04
Improved molecular diagnosis of COVID-19 by the novel, highly sensitive and specific COVID-19-RdRp/Hel real-time reverse transcription-polymerase chain reaction assay validated in vitro and with clinical specimens. The COVID-19-RdRp/Hel assay did not cross-react with other human-pathogenic coronaviruses and respiratory pathogens in cell culture and clinical specimens, whereas the RdRp-P2 assay cross-reacted with SARS-CoV in cell culture. 2020-04-01
Review of the Clinical Characteristics of Coronavirus Disease 2019 (COVID-19). Previous studies have reported epidemiological and clinical characteristics of coronavirus disease 2019 (COVID-19). […] The purpose of this brief review is to summarize those published studies as of late February 2020 on the clinical features, symptoms, complications, and treatments of COVID-19 and help provide guidance for frontline medical staff in the clinical management of this outbreak. 2020-03-05
[Analysis of bronchoscope-guided tracheal intubation in 12 cases with COVID-19 under the personal protective equipment with positive pressure protective hood]. The detection of oropharyngeal swab virus nucleic acid were negative in all 9 healthcare workers, none of them had fever or any respiratory symptoms. 2020-03-05
[Investigation and analysis on characteristics of a cluster of COVID-19 associated with exposure in a department store in Tianjin]. Objective: To describe the epidemiological characteristics of a cluster of COVID-19 cases reported in Baodi district of Tianjin as of 18 February, 2020, which might be associated with the exposure in a local department store, and provide suggestions for prevention and control strategy development. Methods: The basic characteristics, time and area distributions, clinical manifestations, epidemiological history and transmission mode of the COVID-19 cases associated with the department store exposure were analyzed. Results: A total of 40 COVID-19 cases were associated with the department store exposure, accounting for 75.47% of the total confirmed cases (53 cases) reported in Baodi district. […] The main clinical manifestations included fever (95.00%), cough (35.00%), and diarrhea (15.00%). 2020-03-05
[The differential diagnosis of pulmonary infiltrates in cancer patients during the outbreak of the 2019 novel coronavirus disease]. Information of clinical manifestations, history of epidemiology, lab tests and chest CT scan images of visiting patients from February 13 to February 28 were collected. […] This patient denied any contact with confirmed/suspected cases of 2019-nCoV infection and without fever and other respiratory symptoms. […] Considering the negative result of nuclear acid testing, this patient was presumptively diagnosed as viral pneumonia and an experiential anti-infection treatment had been prescribed for him. Conclusions: The 2019 novel coronavirus disease (COVID-19) complicates the clinical scenario of pulmonary infiltrates in cancer patients. […] The epidemic history, clinical manifestation, CT scan image and lab test should be combined consideration. 2020-03-05
Unique epidemiological and clinical features of the emerging 2019 novel coronavirus pneumonia (COVID-19) implicate special control measures. Limited epidemiological and clinical data suggest that the disease spectrum of COVID-19 may differ from SARS or MERS. […] We summarize latest literatures on genetic, epidemiological, and clinical features of COVID-19 in comparison to SARS and MERS and emphasize special measures on diagnosis and potential interventions. 2020-03-31
Clinical and CT features in pediatric patients with COVID-19 infection: Different points from adults. To discuss the different characteristics of clinical, laboratory, and chest computed tomography (CT) in pediatric patients from adults with 2019 novel coronavirus (COVID-19) infection. […] The clinical, laboratory, and chest CT features of 20 pediatric inpatients with COVID-19 infection confirmed by pharyngeal swab COVID-19 nucleic acid test were retrospectively analyzed during 23 January and 8 February 2020. […] The clinical and laboratory information was obtained from inpatient records. […] Fever (12/20, 60%) and cough (13/20, 65%) were the most common symptoms. 2020-04-16
Perspectives on monoclonal antibody therapy as potential therapeutic intervention for Coronavirus disease-19 (COVID-19). Several clinical, genetic and epidemiological features of COVID-19 resemble SARS-CoV infection. 2020-03-24
CT Features of Coronavirus Disease 2019 (COVID-19) Pneumonia in 62 Patients in Wuhan, China. CT images and clinical data were reviewed. […] Compared with early-phase disease (≤ 7 days after the onset of symptoms), advanced-phase disease (8-14 days after the onset of symptoms) was characterized by significantly increased frequencies of GGO plus a reticular pattern, vacuolar sign, fibrotic streaks, a subpleural line, a subpleural transparent line, air bronchogram, bronchus distortion, and pleural effusion; however, GGO significantly decreased in advanced-phase disease. CONCLUSION. CT examination of patients with COVID-19 pneumonia showed a mixed and diverse pattern with both lung parenchyma and the interstitium involved. 2020-03-05
Clinical and High-Resolution CT Features of the COVID-19 Infection: Comparison of the Initial and Follow-up Changes. We aimed to quantify severity of COVID-19 infection on High-Resolution CT and to determine its relationship with clinical parameters. […] From Jan 11, 2020, to Feb 5, 2020, the clinical, laboratory and HRCT features of 42 patients (26-75 years, 25 males) with COVID-19 were analyzed. […] Correlations among clinical parameters, initial CT features and progression of opacifications were evaluated with Spearman correlation and linear regression analysis. […] Patients with the COVID-19 infection usually presented with typical ground-grass opacities and other CT features, which showed significant correlations with some clinical and laboratory measurements. 2020-03-06
The outbreak of COVID-19: An overview. To promptly identify patients and prevent further spreading, physicians should be aware of the travel or contact history of the patient with compatible symptoms. 2020-03-18
The 2019 Novel Coronavirus Outbreak - A Global Threat. There is a spectrum of clinical features from mild to severe life threatening disease with major complications like severe pneumonia, ARDS, acute cardiac injury and septic shock. […] Presence of bilateral ground glass opacity and consolidation on imaging in appropriate clinical background should raise a suspicion about COVID 19. 2020-03-10
What we know so far: COVID-19 current clinical knowledge and research. This article will review the new knowledge of SARS-CoV-2 COVID-19 acute respiratory disease, and summarise its clinical features. 2020-03-23
[Advances on presymptomatic or asymptomatic carrier transmission of COVID-19]. However, such sources of infection cannot be effectively identified due to the symptoms absent. 2020-03-06
[Analysis of myocardial injury in patients with COVID-19 and association between concomitant cardiovascular diseases and severity of COVID-19]. The past medical history of CHD and increased level of cTnI are two independent determinants of clinical disease status in patients with COVID-19. 目的: 分析新型冠状病毒肺炎(COVID-19)危重症患者心肌损伤及患有心血管基础疾病的情况。 2020-03-06
COVID-19 (Novel Coronavirus 2019) - recent trends. COVID-19 is similar to Severe Acute Respiratory Syndrome coronavirus (SARS-CoV) virus in its pathogenicity, clinical spectrum, and epidemiology. […] COVID-19 causes COVID-19 disease that has similar symptoms as SARS-CoV. 2020-03-18
Novel coronavirus 2019-nCoV: prevalence, biological and clinical characteristics comparison with SARS-CoV and MERS-CoV. This study aimed at investigating the global prevalence, biological and clinical characteristics of novel coronavirus, Wuhan China (2019-nCoV), Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV), and Middle East Respiratory Syndrome Coronavirus (MERS-CoV) infection outbreaks. […] We also recorded the information from research documents published in global scientific journals indexed in ISI Web of Science and research centers on the prevalence, biological and clinical characteristics of 2019-nCoV, SARS-CoV, and MERS-CoV. […] The major clinical manifestations in coronavirus infections 2019-nCoV, MERS-CoV, and SARS CoV are fever, chills, cough, shortness of breath, generalized myalgia, malaise, drowsy, diarrhea, confusion, dyspnea, and pneumonia. 2020-03-18
SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor. A TMPRSS2 inhibitor approved for clinical use blocked entry and might constitute a treatment option. 2020-04-01
The deadly coronaviruses: The 2003 SARS pandemic and the 2020 novel coronavirus epidemic in China. While human strains of Coronavirus are associated with about 15% of cases of the common cold, the SARS-CoV-2 may present with varying degrees of severity, from flu-like symptoms to death. 2020-04-15
The Novel Coronavirus - A Snapshot of Current Knowledge. This minireview summarizes the research literature on the virological, clinical and epidemiological aspects of this epidemic published until end of February 2020. 2020-04-08
Middle East respiratory syndrome. This Seminar provides an update on the current knowledge and perspectives on MERS epidemiology, virology, mode of transmission, pathogenesis, diagnosis, clinical features, management, infection control, development of new therapeutics and vaccines, and highlights unanswered questions and priorities for research, improved management, and prevention. 2020-04-13
[The preliminary analysis on the characteristics of the cluster for the Corona Virus Disease]. Whatever happens, screening and isolating close contacts remains essential except for clinical treatment during the epidemic. 2020-03-08
[Healing the schism between public health and medicine, promoting the integration of prevention and treatment]. Since then, although scholars have appealed to incorporating public health and clinical medicine education, and breaking down separations between public health and clinical workforce in China, the effect is yet not so obvious. […] Consequently, the Chinese people have higher expectations on the modernization of public health governance, and the social atmosphere of incorporating preventive medicine and clinical medical education is establishing. […] In future, when combating with novel infectious diseases and public health emergencies, the response capacity of public health system and treatment capacity of clinical system will be significantly improved, while the situation on insufficient integration of prevention and treatment is bound to be reversed. 2020-03-08
[Screening and management of asymptomatic infection of corona virus disease 2019 (COVID-19)]. Few days ago, we conducted a study on the epidemiological and clinical characteristics of asymptomatic infections of COVID-19, and found them might be the infection source. 2020-03-08
Can we contain the COVID-19 outbreak with the same measures as for SARS? COVID-19 differs from SARS in terms of infectious period, transmissibility, clinical severity, and extent of community spread. 2020-04-01
Clinical characteristics of 24 asymptomatic infections with COVID-19 screened among close contacts in Nanjing, China. Previous studies have showed clinical characteristics of patients with the 2019 novel coronavirus disease (COVID-19) and the evidence of person-to-person transmission. […] This study aims to present the clinical characteristics of 24 cases with asymptomatic infection screened from close contacts and to show the transmission potential of asymptomatic COVID-19 virus carriers. […] Their clinical records, laboratory assessments, and chest CT scans were reviewed. […] As a result, none of the 24 asymptomatic cases presented any obvious symptoms while nucleic acid screening. […] Five cases (20.8%) developed symptoms (fever, cough, fatigue, etc.) during hospitalization. […] The remaining 7 (29.2%) cases showed normal CT image and had no symptoms during hospitalization. 2020-03-08
Discovering drugs to treat coronavirus disease 2019 (COVID-19). Several drugs such as chloroquine, arbidol, remdesivir, and favipiravir are currently undergoing clinical studies to test their efficacy and safety in the treatment of coronavirus disease 2019 (COVID-19) in China; some promising results have been achieved thus far. 2020-03-16
Early Epidemiological and Clinical Characteristics of 28 Cases of Coronavirus Disease in South Korea. The epidemiological and clinical characteristics of all 28 cases were analyzed in response to this disease. […] The epidemiological characteristics and early clinical features of the 28 patients from Korea with confirmed COVID-19 were analyzed using COVID-19 reporting and surveillance data and the epidemiological investigation reports prepared by the rapid response team. […] The early symptoms were fever, sore throat, cough or sputum production, chills, and muscle ache. […] The initial symptoms were mostly minor, but the disease was infectious at this stage, resulting from close contact, particularly at home. 2020-03-20
[Epidemiological investigation of a family clustering of COVID-19]. Besides respiratory symptoms, there were also gastrointestinal symptoms, of which diarrhea was the most common one. Conclusion: Family clustering had been an important part for COVID-19 cases. 目的: 通过对1起家庭聚集性新型冠状病毒肺炎8例病例的流行病学调查分析,探讨流行病学特征,为新型冠状病毒肺炎的防控提供依据。 2020-03-09
Repurposing of clinically approved drugs for treatment of coronavirus disease 2019 in a 2019-novel coronavirus (2019-nCoV) related coronavirus model. Our results strongly suggest that CEP is a wide-spectrum inhibitor of pan-betacoronavirus, and clinical trial of CEP for treatment of 2019-nCoV infection is warranted. 2020-03-09
Effectiveness of glucocorticoid therapy in patients with severe novel coronavirus pneumonia: protocol of a randomized controlled trial. Patients who become infected with 2019-nCoV may initially develop mild upper respiratory tract symptoms. […] We will use the clinical improvement rate as our primary endpoint. […] Secondary endpoints include the timing of clinical improvement after intervention, duration of mechanical ventilation, duration of hospitalization, overall incidence of adverse events, as well as rate of adverse events at each visit, and mortality at 2 and 4 weeks. […] Oral and parenteral glucocorticoids have been used in the management of severe respiratory symptoms in coronavirus-infected patients in the past. 2020-03-09
The Incubation Period of Coronavirus Disease 2019 (COVID-19) From Publicly Reported Confirmed Cases: Estimation and Application. There is limited support for many of its key epidemiologic features, including the incubation period for clinical disease (coronavirus disease 2019 [COVID-19]), which has important implications for surveillance and control activities. […] The median incubation period was estimated to be 5.1 days (95% CI, 4.5 to 5.8 days), and 97.5% of those who develop symptoms will do so within 11.5 days (CI, 8.2 to 15.6 days) of infection. […] These estimates imply that, under conservative assumptions, 101 out of every 10 000 cases (99th percentile, 482) will develop symptoms after 14 days of active monitoring or quarantine. 2020-03-22
Clinical characteristics and intrauterine vertical transmission potential of COVID-19 infection in nine pregnant women: a retrospective review of medical records. This study aimed to evaluate the clinical characteristics of COVID-19 in pregnancy and the intrauterine vertical transmission potential of COVID-19 infection. […] Clinical records, laboratory results, and chest CT scans were retrospectively reviewed for nine pregnant women with laboratory-confirmed COVID-19 pneumonia (ie, with maternal throat swab samples that were positive for severe acute respiratory syndrome coronavirus 2 [SARS-CoV-2]) who were admitted to Zhongnan Hospital of Wuhan University, Wuhan, China, from Jan 20 to Jan 31, 2020. […] Other symptoms, including cough (in four of nine patients), myalgia (in three), sore throat (in two), and malaise (in two), were also observed. […] The clinical characteristics of COVID-19 pneumonia in pregnant women were similar to those reported for non-pregnant adult patients who developed COVID-19 pneumonia. 2020-03-18
Compounds with therapeutic potential against novel respiratory 2019 coronavirus. The most promising compound is remdesivir (GS-5734), a nucleotide analog prodrug currently in clinical trials for treating Ebola virus infections. […] LPV/RTV-INFb also improved clinical parameters in marmosets and mice infected with MERS-CoV. 2020-03-10
[The differential diagnosis for novel coronavirus pneumonia and similar lung diseases in general hospitals]. Patients with novel coronavirus pneumonia usually had history of travelling or living in the epidemic area including Wuhan within 14 days before onset, or have been exposed to patients who had fever or respiratory symptoms from the epidemic area, or had clustering diseases. […] In this article, the clinical and chest imaging features of the novel coronavirus pneumonia were reviewed and compared with other infections and non-infectious diffuse pulmonary diseases. 2020-03-10
[Clinical characteristics and influencing factors of patients with novel coronavirus pneumonia combined with liver injury in Shaanxi region]. Objective: To understand the clinical characteristics, change of liver function, influencing factors and prognosis in hospitalized patients with coronavirus disease-19 (COVID-19) combined with liver injury. Methods: The general conditions, biochemical indicators of liver, blood clotting mechanism, routine blood test, UGT1A1 * 28 gene polymorphism and other data of 40 cases with COVID-19 admitted to the isolation ward of Tangdu Hospital were retrospectively analyzed. […] The clinical characteristics, influencing factors and prognosis of liver injury in patients with liver injury group and those with normal liver function group were compared. 2020-03-10
Clinical analysis of 10 neonates born to mothers with 2019-nCoV pneumonia. However, the clinical features of these cases have not been reported, and there is no sufficient evidence for the proper prevention and control of 2019-nCoV infections in neonates. […] The clinical features and outcomes of 10 neonates (including 2 twins) born to 9 mothers with confirmed 2019-nCoV infection in 5 hospitals from January 20 to February 5, 2020 were retrospectively analyzed. […] Among these 9 pregnant women with confirmed 2019-nCoV infection, onset of clinical symptoms occurred before delivery in 4 cases, on the day of delivery in 2 cases, and after delivery in 3 cases. […] In most cases, fever and a cough were the first symptoms experienced, and 1 patient also had diarrhea. […] Clinically, the first symptom in the neonates was shortness of breath (n=6), but other initial symptoms such as fever (n=2), thrombocytopenia accompanied by abnormal liver function (n=2), rapid heart rate (n=1), vomiting (n=1), and pneumothorax (n=1) were observed. 2020-03-13
Immediate Psychological Responses and Associated Factors during the Initial Stage of the 2019 Coronavirus Disease (COVID-19) Epidemic among the General Population in China. Research data are needed to develop evidence-driven strategies to reduce adverse psychological impacts and psychiatric symptoms during the epidemic. […] The online survey collected information on demographic data, physical symptoms in the past 14 days, contact history with COVID-19, knowledge and concerns about COVID-19, precautionary measures against COVID-19, and additional information required with respect to COVID-19. […] In total, 53.8% of respondents rated the psychological impact of the outbreak as moderate or severe; 16.5% reported moderate to severe depressive symptoms; 28.8% reported moderate to severe anxiety symptoms; and 8.1% reported moderate to severe stress levels. […] Female gender, student status, specific physical symptoms (e.g., myalgia, dizziness, coryza), and poor self-rated health status were significantly associated with a greater psychological impact of the outbreak and higher levels of stress, anxiety, and depression (p < 0.05). 2020-03-18
Development of a Laboratory-safe and Low-cost Detection Protocol for SARS-CoV-2 of the Coronavirus Disease 2019 (COVID-19). More critically, there have been reports about the possibility of this virus to transmit even before a virus-carrying person to show symptoms. 2020-03-11
Evaluation of a quantitative RT-PCR assay for the detection of the emerging coronavirus SARS-CoV-2 using a high throughput system. We observed good analytical performance in clinical specimens. 2020-03-17
Positive rate of RT-PCR detection of SARS-CoV-2 infection in 4880 cases from one hospital in Wuhan, China, from Jan to Feb 2020. The RT-PCR detection of viral nucleic acid test (NAT) was one of the most quickly established laboratory diagnosis method in a novel viral pandemic, just as in this COVID-19 outbreak. 4880 cases that had respiratory infection symptoms or close contact with COVID-19 patients in hospital in Wuhan, China, were tested for SARS-CoV-2 infection by use of quantitative RT-PCR (qRT-PCR) on samples from the respiratory tract. 2020-04-14
2019 novel coronavirus (2019-nCoV) outbreak: A new challenge. Following the public-health emergency of international concern (PHEIC) declared by the World Health Organization (WHO) on 30 January 2020 and the recent outbreak caused by 2019 novel coronavirus (2019-nCoV) [officially renamed severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)] in China and 29 other countries, we aimed to summarise the clinical aspects of the novelBetacoronavirus disease (COVID-19) and its possible clinical presentations together with suggested therapeutic algorithms for patients who may require antimicrobial treatment. 2020-04-06
Harnessing the immune system via FcγR function in immune therapy: a pathway to next-gen mAbs. More than 100 therapeutic monoclonal antibodies (mAbs) are approved or in late stage clinical trials, many of which harness the potent FcγR-mediated effector systems to varying degrees. 2020-04-14
[Construction and evaluation of a novel diagnosis process for 2019-Corona Virus Disease]. Take epidemiological history, fever, and the blood lymphocytes decline as clinical indicators, used CT to evaluate the possibility of COVID-19 and range of lung involvement. […] The Xiangya process was constructed according to multi-index, compared with clinical indicators, CT results and national standards, the efficiency of detecting confirmed cases were verified in the test and verification library. Results: A continuous cohort of 382 adults who screened COVID-19 was included in which 261 cases were in the test library and 121 cases were in the verification library. […] Compared with clinical indicators, the sensitivity and specificity of CT were 0.950 and 0.704, respectively. 2020-03-11
CT Manifestations of Novel Coronavirus Pneumonia: A Case Report Three days later, levofloxacin was started because the patient’s symptoms did not improve. 2020-04-15
[Comparison of epidemic characteristics between SARS in2003 and COVID-19 in 2020 in Guangzhou]. Objective: By analyzing the epidemic characteristics and related indicators of SARS (2003) and COVID-19(2020), to explore the reasons for the similarities and differences of the two epidemics, so as to provide reference for epidemic prevention and control. Methods: The general situation, clinical classification, activity history, contact history, family members’ contact and incidence of the two infectious diseases in Guangzhou were collected and used to analyze the time characteristics, occupational characteristics, age characteristics and other key indicators of the two diseases, including the number of cases, composition ratio (%), mean, median, crude mortality, etc. Results: A total of 1 072 cases of SARS (2003) were included in the study. 353 of which were severe cases with the incidence of 30.13%. 43 cases of death were reported with a mortality rate of 4.01%. 2020-03-11
The emergence of a novel coronavirus (SARS-CoV-2), their biology and therapeutic options. Furthermore, we discuss the clinical features and potential therapeutic options that may be effective against SARS-CoV-2. 2020-03-12
Dysregulation of immune response in patients with COVID-19 in Wuhan, China. Demographic and clinical data of all confirmed cases with COVID-19 on admission at Tongji Hospital from January 10 to February 12, 2020, were collected and analyzed. […] The most common symptoms were fever, shortness of breath, expectoration, fatigue, dry cough and myalgia. 2020-04-03
A comparative study on the clinical features of COVID-19 pneumonia to other pneumonias. Its impacts on public health make it paramount to clarify the clinical features with other pneumonias. […] We analyzed the demographic, epidemiological, clinical, and radiological features from those patients, and compared the difference between NCOVID-19 and NON-NCOVID-19. […] The clinical symptoms were similar between NCOVID-19 and NON-NCOVID-19. […] The most common symptoms were fever and cough. 2020-04-03
Chest computed tomography in children with COVID-19 respiratory infection. We recorded findings at any chest CT performed in the included children, along with core clinical observations. […] Three of these five had CT abnormality on the first CT scan (at 2 days, 4 days and 9 days, respectively, after onset of symptoms) in the form of patchy ground-glass opacities; all normalised during treatment. 2020-03-12
Preparing for a COVID-19 pandemic: a review of operating room outbreak response measures in a large tertiary hospital in Singapore. These include engineering controls such as identification and preparation of an isolation operating room, administrative measures such as modification of workflow and processes, introduction of personal protective equipment for staff, and formulation of clinical guidelines for anesthetic management. 2020-04-04
A report of clinical diagnosis and treatment of nine cases of coronavirus disease 2019. The main clinical manifestations were respiratory symptoms and occasional gastrointestinal symptoms. […] In the retrospective analysis, we report nine cases of COVID-19, describe the history of contact, clinical manifestations, the course of diagnosis and clinical treatment before, during and after treatment. 2020-03-16
COVID-19 patients’ clinical characteristics, discharge rate, and fatality rate of meta-analysis. The aim of this study was to analyze the clinical data, discharge rate, and fatality rate of COVID-19 patients for clinical help. […] The clinical data of COVID-19 patients from December 2019 to February 2020 were retrieved from four databases. […] We statistically analyzed the clinical symptoms and laboratory results of COVID-19 patients and explained the discharge rate and fatality rate with a single-arm meta-analysis. […] The main clinical symptoms of COVID-19 patients were fever (88.5%), cough (68.6%), myalgia or fatigue (35.8%), expectoration (28.2%), and dyspnea (21.9%). […] Minor symptoms include headache or dizziness (12.1%), diarrhea (4.8%), nausea and vomiting (3.9%). 2020-04-10
[Efficient management of novel coronavirus pneumonia by efficient prevention and control in scientific manner]. Based on current studies, the author summarized the clinical characteristics and evolution of the novel viral pneumonia, and proposed the key points of diagnosis and treatment, the scientific management of both confirmed and suspected cases, and the scientific management of disease prevention and control. 2020-03-13
[Early detection and disease assessment of patients with novel coronavirus pneumonia]. The novel coronavirus has the characteristics of rapid transmission, atypical clinical symptoms, and easy to affect both lungs, leading to missed diagnosis and misdiagnosis, as well as difficult to detection and assessment at early stage. 2020-03-13
[Potential antiviral therapeutics for 2019 Novel Coronavirus]. Antiviral drugs commonly used in clinical practice, including neuraminidase inhibitors (oseltamivir, paramivir, zanamivir, etc.), ganciclovir, acyclovir and ribavirin, are invalid for 2019-nCoV and not recommended. […] But the efficacy and safety of these drugs for 2019-nCoV pneumonia patients need to be assessed by further clinical trials. 2020-03-13
[Recommendations on extracorporeal life support for critically ill patients with novel coronavirus pneumonia]. Based on the clinical data of novel coronavirus pneumonia (NCP), as well as the dada from previous clinical studies and the recommendations from the Extracorporeal Life Support Organization (ELSO), the committee board of the Chinese Society of Extracorporeal Life Support (CSECLS) made this recommendations to guide clinical ECMO application in the patients with NCP. 2020-03-13
[Analysis of clinical features of 29 patients with 2019 novel coronavirus pneumonia]. Objective: To analyze the clinical characteristics of 2019 novel coronavirus (2019-nCoV) pneumonia and to investigate the correlation between serum inflammatory cytokines and severity of the disease. […] Clinical data were collected and the general information, clinical symptoms, blood test and CT imaging characteristics were analyzed. […] The expression levels of inflammatory cytokines and other markers in the serum of each group were detected, and the changes of these indicators of the three groups were compared and analyzed, as well as their relationship with the clinical classification of the disease. […] Results: (1) The main symptoms of 2019-nCoV pneumonia was fever (28/29) with or without respiratory and other systemic symptoms. […] Conclusion: The clinical characteristics of 2019-nCoV pneumonia are similar to those of common viral pneumonia. 2020-03-13
[Clinical characteristics of 30 medical workers infected with new coronavirus pneumonia]. Objective: To investigate the clinical characteristics of medical staff with novel coronavirus pneumonia(NCP). […] The data reviewed included those of clinical manifestations, laboratory investigation and Radiographic features. […] The average contact times were 12 (7,16) and the average cumulative contact time was 2 (1.5,2.7) h.Clinical symptoms of these patients were fever in 23 patients (76.67%) , headache in 16 petients (53.33%) , fatigue or myalgia in 21patients (70%) , nausea, vomiting or diarrhea in 9 petients (30%) , cough in 25 petients (83.33%) , and dyspnea in 14 petients (46.67%) . 2020-03-13
[Clinical features of 2019 novel coronavirus pneumonia in the early stage from a fever clinic in Beijing]. Objective: To summarize and analyze the clinical and imaging characteristics of patients with 2019 novel coronavirus pneumonia in the early stage in Beijing. […] Methods: A retrospective analysis of clinical and imaging data of 9 patients with 2019 novel coronavirus infection diagnosed in one fever clinicic in Beijing from January 18, 2020 to February 3, 2020. […] The clinical manifestations were fever in 8 cases (8/9) , dry cough in 5 cases (5/9) , pharyngalgia in 4 cases (4/9) , fatigue in 4 cases (4/9) , body soreness in 4 cases (4/9) , and blocked or watery nose in 1 case (1/9) . […] The clinical manifestations are fever and cough. 2020-03-13
[Inhibitors of RAS Might Be a Good Choice for the Therapy of COVID-19 Pneumonia]. Animal studies have shown that RAS inhibitors could effectively relieve symptoms of acute severe pneumonia and respiratory failure. 2020-03-13
[Epidemiological characteristics of confirmed COVID-19 cases in Tianjin]. Objective: To investigate the clinical and epidemiological characteristics of 135 confirmed cases of COVID-19 in Tianjin. Methods: The clinical and epidemiological data of 135 cases of COVID-19 in Tianjin were collected, and the data were analyzed with descriptive method. 2020-03-13
COVID-19: An Update on the Epidemiological, Clinical, Preventive and Therapeutic Evidence and Guidelines of Integrative Chinese-Western Medicine for the Management of 2019 Novel Coronavirus Disease. Similar to outbreaks of other newly identified virus, there is no proven regimen from conventional medicine and most reports managed the patients with lopinavir/ritonavir, ribavirin, beta-interferon, glucocorticoid and supportive treatment with remdesivir undergoing clinical trial. […] We reviewed the latest national and provincial clinical guidelines, retrospective cohort studies, and case series regarding the treatment of COVID-19 by add-on Chinese medicine. […] We have also reviewed the clinical evidence generated from SARS and H1N1 management with hypothesized mechanisms and latest in silico findings to identify candidate Chinese medicines for the consideration of possible trials and management. 2020-03-13
Coronavirus disease-2019: is fever an adequate screening for the returning travelers? However, the recent report on asymptomatic contact transmission of COVID-19 and travelers who passed the symptoms-based screening and tested positive for COVID-19 using reverse transcription polymerase chain reaction (RT-PCR) challenges this approach as body temperature screening may miss travelers incubating the disease or travelers concealing fever during travel. 2020-03-28
A Review of Coronavirus Disease-2019 (COVID-19). The symptoms are usually fever, cough, sore throat, breathlessness, fatigue, malaise among others. […] The computerized tomographic chest scan is usually abnormal even in those with no symptoms or mild disease. 2020-03-23
An exclusive 42 amino acid signature in pp1ab protein provides insights into the evolutive history of the 2019 novel human-pathogenic coronavirus (SARS-CoV-2). The analysis showed that the viral pp1ab has not changed in most isolates throughout the outbreak time, but interestingly a deletion of 8 aa in the virulence factor nonstructural protein 1 was found in a virus isolated from a Japanese patient that did not display critical symptoms. 2020-03-20
The establishment of reference sequence for SARS-CoV-2 and variation analysis. At present, the sensitivity of clinical nucleic acid detection is limited, and it is still unclear whether it is related to genetic variation. […] Establishment of the reference sequence for SARS-CoV-2 could benefit not only biological study of this virus but also diagnosis, clinical monitoring and intervention of SARS-CoV-2 infection in the future. 2020-03-20
Initial clinical features of suspected coronavirus disease 2019 in two emergency departments outside of Hubei, China. Therefore, it is of crucial importance to study the initial clinical features of patients, to better differentiate between infected and uninfected patients outside Hubei. […] The initial clinical data of these patients, such as epidemiological features, symptoms, laboratory results, and chest computed tomography (CT) findings were collected using a standard case report form on admission. 2020-03-24
Risk Factors Associated With Acute Respiratory Distress Syndrome and Death in Patients With Coronavirus Disease 2019 Pneumonia in Wuhan, China. Risk factors for the clinical outcomes of COVID-19 pneumonia have not yet been well delineated. […] To describe the clinical characteristics and outcomes in patients with COVID-19 pneumonia who developed acute respiratory distress syndrome (ARDS) or died. […] Epidemiological, demographic, clinical, laboratory, management, treatment, and outcome data were also collected and analyzed. 2020-03-17
The origin, transmission and clinical therapies on coronavirus disease 2019 (COVID-19) outbreak - an update on the status. The clinical symptoms of COVID-19 patients include fever, cough, fatigue and a small population of patients appeared gastrointestinal infection symptoms. […] In this review, we summarized the latest research progress of the epidemiology, pathogenesis, and clinical characteristics of COVID-19, and discussed the current treatment and scientific advancements to combat the epidemic novel coronavirus. 2020-03-19
Combination of western medicine and Chinese traditional patent medicine in treating a family case of COVID-19 in Wuhan. This report describes the identification, diagnosis, clinical course, and management of three cases from a family, suggests the expected therapeutic effects of SHL on COVID-19, and warrants further clinical trials. 2020-03-14
Single-cell RNA-seq data analysis on the receptor ACE2 expression reveals the potential risk of different human organs vulnerable to 2019-nCoV infection. However, some patients also exhibit non-respiratory symptoms, such as kidney failure, implying that 2019-nCoV could also invade other organs. 2020-03-14
Coronavirus disease 2019: What we know? The purpose of this review is primarily to review the pathogen, clinical features, diagnosis, and treatment of COVID-19, but also to comment briefly on the epidemiology and pathology based on the current evidence. 2020-03-29
Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study. Epidemiological and clinical characteristics of patients with COVID-19 have been reported but risk factors for mortality and a detailed clinical course of illness, including viral shedding, have not been well described. […] Demographic, clinical, treatment, and laboratory data, including serial samples for viral RNA detection, were extracted from electronic medical records and compared between survivors and non-survivors. 2020-04-03
[Consideration and prevention of the aerosol transmission of 2019 novel coronavirus]. Based on the clinical observation, the possibility of aerosol transmission of 2019 novel coronavirus has aroused much attention. 2020-03-15
[Impact of complicated myocardial injury on the clinical outcome of severe or critically ill COVID-19 patients]. Objective: To analyze the clinical characteristics of the severe or critically ill patients with novel coronavirus pneumonia (COVID-19), and evaluate the impact of complicated myocardial injury on the prognosis of these patients. […] The clinical characteristics and hospital mortality rate were analyzed and compared between the patients with or without myocardial injury, which was defined with 3 times higher serum cardiac troponin value. 2020-03-15
[Epidemiological characteristics of 2019 novel coronavirus family clustering in Zhejiang Province]. Descriptive analysis was used to analyze the clinical symptoms and the serial interval between the subsequent cases and the index cases. […] The clinical symptoms between family index cases and subsequent cases are similar, fever is the most common symptoms in the two groups 114 (77.03%) and 92 (48.68%) respectively, the cases with diarrhea symptoms accounted for the least proportion, which were 7 (4.73%) and 5 (2.65%). 2020-03-15
Clinical and CT imaging features of the COVID-19 pneumonia: Focus on pregnant women and children. We aimed to investigate the clinical and CT features in the pregnant women and children with this disease, which have not been well reported. […] Clinical and CT data of 59 patients with COVID-19 from January 27 to February 14, 2020 were retrospectively reviewed, including 14 laboratory-confirmed non-pregnant adults, 16 laboratory-confirmed and 25 clinically-diagnosed pregnant women, and 4 laboratory-confirmed children. […] The clinical and CT features were analyzed and compared. […] Atypical clinical findings of pregnant women with COVID-19 could increase the difficulty in initial identification. […] CT was the modality of choice for early detection, severity assessment, and timely therapeutic effects evaluation for the cases with epidemic and clinical features of COVID-19 with or without laboratory confirmation. […] The exposure history and clinical symptoms were more helpful for screening in children versus chest CT. 2020-04-16
Clinical features of COVID-19 in elderly patients: A comparison with young and middle-aged patients. Due to the general susceptibility of new coronaviruses, the clinical characteristics and outcomes of elderly and young patients may be different. […] To analyze the clinical characteristics of elderly patients with 2019 new-type coronavirus pneumonia (COVID-19). […] Compare the clinical characteristics of elderly with Young and Middle-aged patients. […] The most common symptoms in both groups were fever, followed by cough and sputum. 2020-04-01
Clinical characteristics of severe acute respiratory syndrome coronavirus 2 reactivation. This study aimed to evaluate the clinical characteristics of the SARS-CoV-2 reactivation. […] Clinical records, laboratory results, and chest CT scans were retrospectively reviewed for 55 patients with laboratory-confirmed COVID-19 pneumonia (i.e., with throat swab samples that were positive for SARS-CoV-2) who were admitted to Zhongnan Hospital of Wuhan University, Wuhan, China, from Jan. 8 to Feb. […] Among the 5 reactivated patients, other symptoms were also observed, including fever, cough, sore throat, and fatigue. […] Findings from this small group of cases suggested that there was currently evidence for reactivation of SARS-CoV-2 and there might be no specific clinical characteristics to distinguish them. 2020-04-16
Clinical progression of patients with COVID-19 in Shanghai, China. Studies on the 2019 novel coronavirus disease (COVID-19) have generally been limited to the description of the epidemiology and initial clinical characteristics. […] The duration from onset of symptoms to hospitalization was 4(2-7) days in symptomatic patients. […] The estimated median duration of fever in all the patients with fever was 10 days (95 confidential intervals [CIs]: 8-11 days) after onset of symptoms. […] Patients who were transferred to intensive care units (ICU) had significantly longer duration of fever as compared to those not in ICU (31 days v.s. 9 days after onset of symptoms, respectively, P <0.0001). […] Radiological aggravation of initial image was observed in 163 (65.7%) patients on day 7 after onset of symptoms. […] The clinical progression pattern suggests that early control of viral replication and application of host-directed therapy in later stage is essential to improve the prognosis of CVOID-19. 2020-04-16
Arbidol combined with LPV/r versus LPV/r alone against Corona Virus Disease 2019: A retrospective cohort study. Baseline clinical, laboratory, and chest CT characteristics were similar between groups. […] In patients with COVID-19, the apparent favorable clinical response with arbidol and LPV/r supports further LPV/r only. 2020-04-16
The SARS-CoV-2 outbreak: what we know. This paper aggregates and consolidates the epidemiology, clinical manifestations, diagnosis, treatments and preventions of this new type of coronavirus. 2020-04-01
Prominent changes in blood coagulation of patients with SARS-CoV-2 infection. Up to now, clinical features and treatment of patients infected with SARS-CoV-2 have been reported in detail. 2020-04-01
Potential preanalytical and analytical vulnerabilities in the laboratory diagnosis of coronavirus disease 2019 (COVID-19). Some practical indications can hence be identified for minimizing the risk of diagnostic errors, encompassing the improvement of diagnostic accuracy by combining clinical evidence with results of chest computed tomography (CT) and RT-PCR, interpretation of RT-PCR results according to epidemiologic, clinical and radiological factors, recollection and testing of upper (or lower) respiratory specimens in patients with negative RT-PCR test results and high suspicion or probability of infection, dissemination of clear instructions for specimen (especially swab) collection, management and storage, together with refinement of molecular target(s) and thorough compliance with analytical procedures, including quality assurance. 2020-04-01
[A pathological report of three COVID-19 cases by minimally invasive autopsies]. Objective: To investigate the pathological characteristics and the clinical significance of novel coronavirus (2019-nCoV)-infected pneumonia (termed by WHO as corona virus disease 2019, COVID-19). Methods: Minimally invasive autopsies from lung, heart, kidney, spleen, bone marrow, liver, pancreas, stomach, intestine, thyroid and skin were performed on three patients died of novel coronavirus pneumonia in Chongqing, China. 2020-03-15
Diagnosis and clinical management of severe acute respiratory syndrome Coronavirus 2 (SARS-CoV-2) infection: an operational recommendation of Peking Union Medical College Hospital (V2.0). The clinical features include fever, coughing, shortness of breath, and inflammatory lung infiltration. 2020-03-17
A tug-of-war between severe acute respiratory syndrome coronavirus 2 and host antiviral defence: lessons from other pathogenic viruses. Human infection with SARS-CoV-2 leads to a wide range of clinical manifestations ranging from asymptomatic, mild, moderate to severe. 2020-03-17
A systematic review on the efficacy and safety of chloroquine for the treatment of COVID-19. We included six articles (one narrative letter, one in-vitro study, one editorial, expert consensus paper, two national guideline documents) and 23 ongoing clinical trials in China. […] There is rationale, pre-clinical evidence of effectiveness and evidence of safety from long-time clinical use for other indications to justify clinical research on chloroquine in patients with COVID-19. […] However, clinical use should either adhere to the Monitored Emergency Use of Unregistered Interventions (MEURI) framework or be ethically approved as a trial as stated by the World Health Organization. […] Safety data and data from high-quality clinical trials are urgently needed. 2020-03-16
[Recommendations on the clinical management of the COVID-19 infection by the «new coronavirus» SARS-CoV2. Spanish Paediatric Association working group]. On 31 December 2019, the Wuhan Municipal Committee of Health and Healthcare (Hubei Province, China) reported that there were 27 cases of pneumonia of unknown origin with symptoms starting on the 8 December. […] The Ministry of Health summoned the Specialties Societies to prepare a clinical protocol for the management of COVID-19. 2020-04-04
Asymptomatic carrier state, acute respiratory disease, and pneumonia due to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2): Facts and myths. To date, effective treatment is lacking; however, clinical trials investigating the efficacy of several agents, including remdesivir and chloroquine, are underway in China. 2020-04-09
Prevalence of comorbidities in the novel Wuhan coronavirus (COVID-19) infection: a systematic review and meta-analysis. The result showed the most prevalent clinical symptom was fever ( 91 ± 3, 95% CI 86-97% ), followed by cough (67 ± 7, 95% CI 59-76%), fatigue ( 51 ± 0, 95% CI 34-68% ) and dyspnea ( 30 ± 4, 95% CI 21-40%). 2020-03-16
Patients of COVID-19 may benefit from sustained lopinavir-combined regimen and the increase of eosinophil may predict the outcome of COVID-19 progression. To explore the epidemiological information, clinical characteristics, therapeutic outcomes and temporal progression of laboratory findings in 2019-coronavirus disease (COVID-19) patients exposed to lopinavir. […] Mainly initial symptoms were cough and low fever (37.3-38.0 ℃). 2020-03-16
Clinical characteristics of refractory COVID-19 pneumonia in Wuhan, China. The cases were divided into general and refractory COVID-19 groups according to the clinical efficacy after hospitalization, and the difference between groups were compared. […] Nearly 50% COVID-19 patients could not reach obvious clinical and radiological remission within 10 days after hospitalization. 2020-03-16
False-Negative Results of Real-Time Reverse-Transcriptase Polymerase Chain Reaction for Severe Acute Respiratory Syndrome Coronavirus 2: Role of Deep-Learning-Based CT Diagnosis and Insights from Two Cases. Here, we report two representative false-negative cases and discuss the supplementary role of clinical data with rRT-PCR, including laboratory examination results and computed tomography features. 2020-03-24
[Advances in the research of mechanism of pulmonary fibrosis induced by Corona Virus Disease 2019 and the corresponding therapeutic measures]. Extensive epidemiological, viral immunological, and current clinical evidences support the possibility that pulmonary fibrosis may be one of the major complications in COVID-19 patients. 2020-03-16
[Management strategies for patients with gynecological malignancies during the outbreak of COVID19]. Objective: To explore the management strategies for patients with gynecological malignant tumors during the outbreak and transmission of COVID19. Methods: We retrospectively analyzed the clinical characteristics, treatment, and disease outcomes of three patients with gynecological malignancies associated with COVID19 in Renmin Hospital of Wuhan University in January 2020, and proposed management strategies for patients with gynecological tumors under risk of COVID19. Results: Three patients were treated COVID19 based on the national diagnosis and treatment protocol as well as research progress. […] Meanwhile, these patients were appropriately adjusted the treatment plan in accordance with the clinical guidelines for gynecological tumors. 2020-03-16
Clinical Features and Chest CT Manifestations of Coronavirus Disease 2019 (COVID-19) in a Single-Center Study in Shanghai, China. The purpose of this study was to assess the clinical features and CT manifestations of COVID-19 by comparing patients with COVID-19 pneumonia with patients with non-COVID-19 pneumonia who presented at a fever observation department in Shanghai, China. MATERIALS AND METHODS. Patients were retrospectively enrolled in the study from January 19 through February 6, 2020. […] No statistical difference in clinical features was observed (p > 0.05), with the exception of leukocyte and platelet counts (p < 0.05). […] The mean (± SD) interval between onset of symptoms and admission to the fever observation department was 4.40 ± 2.00 and 5.52 ± 4.00 days for patients with positive and negative RT-PCR test results, respectively. 2020-03-16
Coronavirus Disease 2019 (COVID-19): A Systematic Review of Imaging Findings in 919 Patients. Imaging patterns corresponding to clinical improvement usually occur after week 2 of the disease and include gradual resolution of consolidative opacities and decrease in the number of lesions and involved lobes. CONCLUSION. This systematic review of current literature on COVID-19 provides insight into the initial and follow-up CT characteristics of the disease. 2020-03-16
Clinical features of deaths in the novel coronavirus epidemic in China. Clinical data of fatal cases published by the Chinese Government were studied. […] As of 2 February 2020, the clinical data of 46 fatal cases were identified. 2020-03-16
Can the Coronavirus Disease 2019 (COVID-19) Affect the Eyes? A Review of Coronaviruses and Ocular Implications in Humans and Animals. Clinical entities such as conjunctivitis, anterior uveitis, retinitis, and optic neuritis have been documented in feline and murine models. 2020-04-13
Clinical Features of 69 Cases with Coronavirus Disease 2019 in Wuhan, China. Related clinical features are needed. […] The most common symptoms were fever (60[87%]), cough (38[55%]), and fatigue (29[42%]). 2020-03-16
Anesthetic Management of Patients with COVID 19 Infections during Emergency Procedures. The aim of the present study was to prevent cross-infection in the operating room during emergency procedures for patients with confirmed or suspected 2019 novel coronavirus (2019-nCoV) by following anesthesia management protocols, and to document clinical- and anesthesia-related characteristics of these patients. […] This was a retrospective, multicenter clinical study. 2020-04-08
Thrombocytopenia is associated with severe coronavirus disease 2019 (COVID-19) infections: A meta-analysis. Low platelet count is associated with increased risk of severe disease and mortality in patients with COVID-19, and thus should serve as clinical indicator of worsening illness during hospitalization. 2020-04-14
Clinical, laboratory and imaging features of COVID-19: A systematic review and meta-analysis. Clinical, laboratory, and imaging features have been partially characterized in some observational studies. […] We performed a systematic literature review with meta-analysis, using three databases to assess clinical, laboratory, imaging features, and outcomes of COVID-19 confirmed cases. 2020-04-01
Clinical features and dynamics of viral load in imported and non-imported patients with COVID-19. To compare the clinical characteristics and the dynamics of viral load between the imported and non-imported patients with COVID-19. […] COVID-19 can present as pneumonia with less onset of symptoms, and the infectivity of SARS-CoV2 may gradually decrease in the tertiary patients. 2020-03-17
Epidemiology of COVID-19 Among Children in China. Although clinical manifestations of children’s COVID-19 cases were generally less severe than those of adult patients, young children, particularly infants, were vulnerable to infection. 2020-04-09
A 55-Day-Old Female Infant infected with COVID 19: presenting with pneumonia, liver injury, and heart damage. We report a 55-day-old case with COVID-19 confirmed in China and describe the identification, diagnosis, clinical course, and treatment of the patient, including the disease progression from day 7 to day 11 of illness. […] When managing such patients, frequent and careful clinical monitoring is essential. 2020-03-17
Clinical outcome of 55 asymptomatic cases at the time of hospital admission infected with SARS-Coronavirus-2 in Shenzhen, China. We study epidemiological and clinical outcome of 55 asymptomatic carriers who were laboratory-confirmed positive for the SARS-Coronavirus-2 by testing the nucleic acid of the pharyngeal swab samples. 2020-03-17
Clinical features of pediatric patients with COVID-19: a report of two family cluster cases. Both clinical features and laboratory examination results of the children and their family members were described. […] The two confirmed children only presented with mild respiratory or gastrointestinal symptoms. […] Infected children have relatively milder clinical symptoms than infected adults. 2020-03-17
Safety and efficacy of different anesthetic regimens for parturients with COVID-19 undergoing Cesarean delivery: a case series of 17 patients. We also recorded the patients’ demographic and clinical characteristics, anesthesia and surgery-related data, maternal and neonatal complications, as well as the health status of the involved medical staff. […] The clinical characteristics of 17 pregnant women infected with SARS-CoV-2 were similar to those previously reported in non-pregnant adult patients. 2020-04-03
An Analysis of 38 Pregnant Women with COVID-19, Their Newborn Infants, and Maternal-Fetal Transmission of SARS-CoV-2: Maternal Coronavirus Infections and Pregnancy Outcomes. In addition, it analyzes literature describing 38 pregnant women with COVID-19 and their newborns in China to assess the effects of SARS-CoV-2 on the mothers and infants including clinical, laboratory and virologic data, and the transmissibility of the virus from mother to fetus. 2020-03-17
Early Clinical and CT Manifestations of Coronavirus Disease 2019 (COVID-19) Pneumonia. OBJECTIVE. The purpose of this study was to investigate early clinical and CT manifestations of coronavirus disease (COVID-19) pneumonia. MATERIALS AND METHODS. Patients with COVID-19 pneumonia confirmed by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) nucleic acid test (reverse transcription-polymerase chain reaction) were enrolled in this retrospective study. […] The clinical manifestations, laboratory results, and CT findings were evaluated. RESULTS. One hundred eight patients (38 men, 70 women; age range, 21-90 years) were included in the study. […] The clinical manifestations were fever in 94 of 108 (87%) patients, dry cough in 65 (60%), and fatigue in 42 (39%). […] Vascular thickening (86 patients [80%]), crazy paving pattern (43 patients [40%]), air bronchogram sign (52 patients [48%]), and halo sign (69 [64%]) were also observed in this study. CONCLUSION. The early clinical and laboratory findings of COVID-19 pneumonia are low to midgrade fever, dry cough, and fatigue with normal WBC count, reduced lymphocyte count, and elevated high-sensitivity C-reactive protein level. 2020-03-17
Epidemiologic and Clinical Characteristics of 91 Hospitalized Patients with COVID-19 in Zhejiang, China: A retrospective, multi-centre case series. Recent studies have focused initial clinical and Epidemiologic characteristics on the COVID-19, mainly revealing situation in Wuhan, Hubei. […] To reveal more data on the epidemiologic and clinical characteristics of COVID-19 patients outside of Wuhan, in Zhejiang, China. […] Retrospective case series. 88 cases of laboratory-confirmed and 3 cases of clinical-confirmed COVID-19 were admitted to five hospitals in Zhejiang province, China. […] Of all 91 patients, 88 (96.70%) were laboratory-confirmed COVID-19 with throat swab samples that tested positive for SARS-Cov-2 while 3 (3.30%) were clinical-diagnosed COVID-19 cases. […] The most common symptoms were fever (71.43%), cough (60.44%) and fatigue (43.96%). 2020-03-17
Platelet-to-lymphocyte ratio is associated with prognosis in patients with coronavirus disease-19. Demographic, clinical, blood routine results, other laboratory results, and treatment data were collected and analyzed. 2020-03-28
Diagnostic utility of clinical laboratory data determinations for patients with the severe COVID-19. The role of clinical laboratory data in the differential diagnosis of the severe forms of COVID-19 has not been definitely established. […] IL-6 and d-D were closely related to the occurrence of severe COVID-19 in the adult patients, and their combined detection had the highest specificity and sensitivity for early prediction of the severity of COVID-19 patients, which has important clinical value. 2020-04-10
Successful recovery of COVID-19 pneumonia in a renal transplant recipient with long-term immunosuppression. We report here the clinical features and therapeutic course of the first reported renal transplant recipient with confirmed COVID-19 pneumonia. […] His overall clinical characteristics (symptoms, laboratory examinations, and chest CT) were similar to those of non-transplanted COVID-19 patients. 2020-04-01
Epidemiology, causes, clinical manifestation and diagnosis, prevention and control of coronavirus disease (COVID-19) during the early outbreak period: a scoping review. In this scoping review, 65 research articles published before 31 January 2020 were analyzed and discussed to better understand the epidemiology, causes, clinical diagnosis, prevention and control of this virus. […] Reported symptoms include fever, cough, fatigue, pneumonia, headache, diarrhea, hemoptysis, and dyspnea. […] During this early period, published research primarily explored the epidemiology, causes, clinical manifestation and diagnosis, as well as prevention and control of the novel coronavirus. 2020-03-19
Post-discharge surveillance and positive virus detection in two medical staff recovered from coronavirus disease 2019 (COVID-19), China, January to February 2020. During the post-discharge surveillance after clinical recovery, swabs were positive in two asymptomatic cases (3.23%). […] Case 1 had presented typical clinical and radiological manifestations on admission, while manifestation in Case 2 was very mild. 2020-03-23
[Challenges and countermeasures on Chinese malaria elimination programme during the coronavirus disease 2019 (COVID-19) outbreak]. Due to the extensive spread and high transmission ability of the COVID-19, there is a possibility of virus infections among malaria cases during the medical care-seeking behaviors and among healthcare professionals during clinical diagnosis and treatment, sample collection and testing and epidemiological surveys. 2020-03-19
[Using the big data ofinternet to understand coronavirus disease 2019’s symptom characteristics: a big data study]. Objective: Analyzing the symptom characteristics of Coronavirus Disease 2019(COVID-19) to improve its prevention. Methods: Using Baidu Index Platform ( and the website of Chinese Center for Disease Control and Prevention as data resources to obtain the search volume (SV) of keywords for symptoms associated with COVID-19 from January 1 to February 20 in each year from 2017 to 2020, in Hubei province and other top 10 impacted provinces in China and the epidemic data. […] The differences and characteristics of the SV of COVID-19-related symptoms, and the correlation between the SV of COVID-19 and new confirmed or suspected cases were analyzed and the hysteresis effects were discussed. Results: Compared the data from January 1 to February 20, 2020, with the SV for the same period of previous three years, Hubei’s SV for cough, fever, diarrhea, chest tightness, dyspnea and other symptoms were significantly increased. […] The total SV of lower respiratory symptoms was significantly higher than that of upper respiratory symptoms (P<0.001). […] The results of the distributed lag model suggested that the patients who retrieved relevant symptoms on the Internet may begin to see a doctor in 2-3 days later and be diagnosed in 3-4 days later. Conclusions: The total SV of lower respiratory symptoms is higher than that of upper respiratory symptoms, and the SV of diarrhea also increased significantly. […] It warns us to pay attention to not only the symptoms of lower respiratory tract, but also the gastrointestinal symptoms, especially diarrhea in patients with COVID-19. 2020-03-18
Pregnancy and Perinatal Outcomes of Women With Coronavirus Disease (COVID-19) Pneumonia: A Preliminary Analysis. OBJECTIVE. The purpose of this study was to describe the clinical manifestations and CT features of coronavirus disease (COVID-19) pneumonia in 15 pregnant women and to provide some initial evidence that can be used for guiding treatment of pregnant women with COVID-19 pneumonia. MATERIALS AND METHODS. We reviewed the clinical data and CT examinations of 15 consecutive pregnant women with COVID-19 pneumonia in our hospital from January 20, 2020, to February 10, 2020. […] Symptoms and laboratory results were analyzed, treatment experiences were summarized, and clinical outcomes were tracked. RESULTS. Eleven patients had successful delivery (10 cesarean deliveries and one vaginal delivery) during the study period, and four patients were still pregnant (three in the second trimester and one in the third trimester) at the end of the study period. […] The most common onset symptoms of COVID-19 pneumonia in pregnant women were fever (13/15 patients) and cough (9/15 patients). […] The four patients who were still pregnant at the end of the study period were not treated with antiviral drugs but had achieved good recovery. CONCLUSION. Pregnancy and childbirth did not aggravate the course of symptoms or CT features of COVID-19 pneumonia. 2020-03-18
A Trial of Lopinavir-Ritonavir in Adults Hospitalized with Severe Covid-19. The primary end point was the time to clinical improvement, defined as the time from randomization to either an improvement of two points on a seven-category ordinal scale or discharge from the hospital, whichever came first. […] Treatment with lopinavir-ritonavir was not associated with a difference from standard care in the time to clinical improvement (hazard ratio for clinical improvement, 1.24; 95% confidence interval [CI], 0.90 to 1.72). […] In a modified intention-to-treat analysis, lopinavir-ritonavir led to a median time to clinical improvement that was shorter by 1 day than that observed with standard care (hazard ratio, 1.39; 95% CI, 1.00 to 1.91). […] (Funded by Major Projects of National Science and Technology on New Drug Creation and Development and others; Chinese Clinical Trial Register number, ChiCTR2000029308.). 2020-04-12
Insight into COVID-2019 for pediatricians. From the perspective of clinical pediatricians as the first line fighting the epidemic, this paper will discuss the clinical characteristics, prevention and control measures, outcomes, diagnosis, and treatment of pediatric cases. 2020-04-16
[Recommendations for general surgery clinical practice in 2019 coronavirus disease situation]. The 2019 coronavirus disease(COVID-19) is a highly infectious disease, has a long incubation period and a variety of clinical manifestations, which has a significant impact on public health and life. […] In order to implement the central government’s decision-making deployment and defeat the COVID-19 as soon as possible, we had focused on the key points in the clinical work of general surgery according to latest relevant guidelines, literature and experience in epidemic prevention. 2020-03-19
[2019-nCoV: new challenges from coronavirus]. The outbreak of pneumonia caused by the novel coronavirus (2019-nCoV) in Wuhan, Hubei province of China, at the end of 2019 shaped tremendous challenges to China’s public health and clinical treatment. […] The virus belongs to the β genus Coronavirus in the family Corornaviridae, and is closely related to SARS-CoV and MERS-CoV, causing severe symptoms of pneumonia. […] After the outbreak of this disease, Chinese scientists invested a lot of energy to carry out research by developing rapid diagnostic reagents, identifying the characters of the pathogen, screening out clinical drugs that may inhibit the virus, and are rapidly developing vaccines. 2020-03-19
[Coronavirus disease 2019 (COVID-19): update for anesthesiologists and intensivists March 2020]. Unlike other acute infectious diseases progressing to sepsis, the severe courses of COVID19 seemingly show prolonged progression from onset of first symptoms to life-threatening deterioration of (primarily) lung function. 2020-04-10
AI-Driven Tools for Coronavirus Outbreak: Need of Active Learning and Cross-Population Train/Test Models on Multitudinal/Multimodal Data. Beside clinical procedures and treatments, since Artificial Intelligence (AI) promises a new paradigm for healthcare, several different AI tools that are built upon Machine Learning (ML) algorithms are employed for analyzing data and decision-making processes. 2020-03-20
Is nicotine exposure linked to cardiopulmonary vulnerability to COVID-19 in the general population? While approximately 80% of infected individuals have minimal symptoms, around 15-20% need to be hospitalized, greatly stressing global healthcare systems. 2020-03-30
Alert for non-respiratory symptoms of Coronavirus Disease 2019 (COVID-19) patients in epidemic period: A case report of familial cluster with three asymptomatic COVID-19 patients. Here we reported the screening, clinical feathers, and treatment process of a family cluster involving three COVID-19 patients. 2020-03-19
A doubt of multiple introduction of SARS-CoV-2 in Italy: A preliminary overview. To better understand its dynamics in Italy, we analyzed complete genomes of SARS-CoV-2 isolates, obtained directly from clinical samples. 2020-03-28
2019-nCoV: The Identify-Isolate-Inform (3I) Tool Applied to a Novel Emerging Coronavirus. After initial assessment for symptoms and epidemiological risk factors, including travel to affected areas and exposure to confirmed 2019-nCoV patients within 14 days, patients are classified in a risk-stratified system. 2020-03-23
The critical role of laboratory medicine during coronavirus disease 2019 (COVID-19) and other viral outbreaks. Despite there being evidence that laboratory tests are vital throughout many clinical pathways, there are at least three major areas where in vitro diagnostics can also provide essential contributions to diagnostic reasoning and managed care of patients with suspected or confirmed SARS-CoV-2 infection. […] Some proactive and reactive strategies may hence be identified to confront this serious healthcare challenge, which entail major investments on conventional laboratory resources, reinforcement of regional networks of clinical laboratories, installation of mobile laboratories, as well as being proactive in establishing laboratory emergency plans. 2020-04-01
Evaluation of the Effectiveness of Surveillance and Containment Measures for the First 100 Patients with COVID-19 in Singapore - January 2-February 29, 2020. Singapore adopted a multipronged surveillance strategy that included applying the case definition at medical consults, tracing contacts of patients with laboratory-confirmed COVID-19, enhancing surveillance among different patient groups (all patients with pneumonia, hospitalized patients in intensive care units [ICUs] with possible infectious diseases, primary care patients with influenza-like illness, and deaths from possible infectious etiologies), and allowing clinician discretion (i.e., option to order a test based on clinical suspicion, even if the case definition was not met) to identify COVID-19 patients. […] Application of the case definition and contact tracing identified 73 patients, 16 were detected by enhanced surveillance, and 11 were identified by laboratory testing based on providers’ clinical discretion. 2020-03-20
Association of radiologic findings with mortality of patients infected with 2019 novel coronavirus in Wuhan, China. We retrospective studied 27 consecutive patients who were confirmed NCIP, the clinical characteristics and CT image findings were collected, and the association of radiologic findings with mortality of patients was evaluated. 27 patients included 12 men and 15 women, with median age of 60 years (IQR 47-69). 17 patients discharged in recovered condition and 10 patients died in hospital. 2020-03-25
COVID-19 epidemic in Switzerland: on the importance of testing, contact tracing and isolation. There are likely many people with undetected SARS-CoV-2 infection because testing efforts are currently not detecting all infected people, including some with clinical disease compatible with COVID-19. 2020-03-25
COVID-19 - what should anaethesiologists and intensivists know about it? Spreading mainly through the droplet route, the virus causes mild symptoms in the majority of cases, the most common being: fever (80%), dry cough (56%), fatigue (22%) and muscle pain (7%); less common symptoms include a sore throat, a runny nose, diarrhea, hemoptysis and chills. […] The article presents basic information about etiology, pathogenesis and diagnostics (with particular emphasis on the importance of tomocomputer imaging), clinical picture, treatment and prevention of the infection. 2020-03-26
WHO International Health Regulations Emergency Committee for the COVID-19 outbreak. These measures for early detection and screening of cases should be followed by full efforts to produce research-based evidence by thoroughly analyzing epidemiological, clinical and immunological data, which will facilitate the development of vaccines and therapeutics for COVID-19. 2020-04-08
[Standardized diagnosis and treatment of colorectal cancer during the outbreak of corona virus disease 2019 in Renji hospital]. Although colorectal surgery is not a front-line subject in the fight against the epidemic, but in this special situation, it is a difficult task to provide the highest quality medical services and ensure the orderly clinical work, on the premise of maximizing the protection for patients and their families, health of medical staff, and the safety of wards and hospitals, We summarize how to carry out the clinical practice of colorectal surgery under the situation of the prevention and control of the COVID-19 epidemiology, including the procedures of diagnose and treatment for emergency patients with colorectal tumor, and share the experiences of the diagnosis of colorectal tumor, the management of patients with colorectal cancer who are scheduled to be admitted for surgery, the protection of wards, the perioperative management. 2020-03-23
[Chemotherapy strategy for colorectal cancer under the outbreak of corona virus disease 2019]. Clinicians should make individual clinical decisions based on the specifics of each patient during epidemic situation. 2020-03-23
Investigation of three clusters of COVID-19 in Singapore: implications for surveillance and response measures. We gathered epidemiological and clinical data from individuals with confirmed COVID-19, via interviews and inpatient medical records, and we did field investigations to assess interactions and possible modes of transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). 2020-04-03
CT manifestations of coronavirus disease-2019: A retrospective analysis of 73 cases by disease severity. The CT manifestations and clinical data of 73 patients with COVID-19 were retrospectively collected in 6 hospitals from Jan 21 to Feb 3, 2020. 2020-04-10
Clinical features of severe pediatric patients with coronavirus disease 2019 in Wuhan: a single center’s observational study. We aimed to describe the clinical features of severe pediatric patients with COVID-19. […] We collected information including demographic data, symptoms, imaging data, laboratory findings, treatments and clinical outcomes of the patients with severe COVID-19. […] The most common symptoms were polypnea (8/8), followed by fever (6/8) and cough (6/8). 2020-03-20
First Pediatric Case of Coronavirus Disease 2019 in Korea. In this report, we present mild clinical course of her pneumonia that did not require antiviral treatment and serial viral test results from multiple specimens. 2020-03-23
Molecular basis of COVID-19 relationships in different species: a one health perspective. Elseways, the recurrent virus exposure over a short time-lapse might result in the Antibody Dependent Enhancement, triggering the violent immune reaction responsible for the severe clinical outcomes observed in the Hubei province. 2020-04-01
Computed Tomography Manifestations of 5 Cases of the Novel Coronavirus Disease 2019 (COVID-19) Pneumonia From Patients Outside Wuhan. Clinical, laboratory, and computed tomography (CT) findings of 5 cases of the novel Coronavirus Disease 2019 (COVID-19) pneumonia from patients outside of Wuhan were reviewed. […] With a history of exposure or travelling, symptoms of fever and cough, and the typical CT manifestation such as ground-glass opacity with a peripheral distribution, we should also think of the possibility of the COVID-19 pneumonia in patients outside of Wuhan. 2020-03-20
COVID-19: a recommendation to examine the effect of hydroxychloroquine in preventing infection and progression. The transition from first symptoms to acute respiratory distress syndrome (ARDS) is highly likely to be due to uncontrolled cytokine release. […] However, the clinical use of CQ can cause severe side effects. […] It has a safer clinical profile and is suitable for those who are pregnant. […] We herein strongly urge that clinical trials are performed to assess the preventive effects of HCQ in both disease infection and progression. 2020-03-20
Hypothesis for potential pathogenesis of SARS-CoV-2 infection-a review of immune changes in patients with viral pneumonia. Although most patients have mild symptoms and good prognosis after infection, some patients developed severe and die from multiple organ complications. 2020-04-07
Expert consensus for managing pregnant women and neonates born to mothers with suspected or confirmed novel coronavirus (COVID-19) infection. To provide clinical management guidelines for novel coronavirus (COVID-19) in pregnancy. 2020-04-13
Eleven faces of coronavirus disease 2019. We aim to describe here the various clinical presentations of this disease by examining eleven cases. […] Electronic medical records of 11 patients with COVID-19 were collected, and demographics, clinical manifestations, outcomes, key laboratory results, and radiological images are discussed. […] The clinical course of the eleven cases demonstrated the complexity of the COVID-19 profile with different clinical presentations. […] Clinical manifestations range from asymptomatic cases to patients with mild and severe symptoms, with or without pneumonia. […] Patients with common allergic diseases did not develop distinct symptoms and severe courses. […] All different clinical characteristics of COVID-19 should be taken into consideration to identify patients that need to be in strict quarantine for the efficient containment of the pandemic. 2020-04-06
The clinical characteristics of pneumonia patients coinfected with 2019 novel coronavirus and influenza virus in Wuhan, China. In this study, we describe the clinical characteristics of those patients who got infected with COVID-19 as well as influenza virus. […] Common symptoms at onset of illness included fever (five [100%] patients), cough (five [100%] patients), shortness of breath (five [100%] patients), nasal tampon (three [60%] patients), pharyngalgia (three [60%] patients), myalgia (two [40%] patients), fatigue (two [40%] patients), headache (two [40%] patients), and expectoration (two [40%] patients). […] In conclusion, those patients with both COVID-19 and influenza virus infection did not appear to show a more severe condition because based on the laboratory findings, imaging studies, and patient prognosis, they showed similar clinical characteristics as those patients with COVID-19 infection only. […] However, it is worth noting that the symptoms of nasal tampon and pharyngalgia may be more prone to appear for those coinfection patients. 2020-03-31
Rhabdomyolysis as Potential Late Complication Associated with COVID-19. Rapid clinical recognition of rhabdomyolysis symptoms in patients with severe acute respiratory syndrome coronavirus 2 infection can be lifesaving. 2020-03-20
Practical recommendations for the perioperative management of the patient with suspection or serious infection by coronavirus SARS-CoV. Infections in humans cause a broad clinical spectrum ranging from mild upper respiratory tract infection, to severe acute respiratory distress syndrome and sepsis. 2020-04-01
Hiding in Plain Sight: an Approach to Treating Patients with Severe COVID-19 Infection. Clinical trials are needed to determine whether this drug combination might be used to treat patients with severe COVID-19 infection. 2020-03-25
Profiling Early Humoral Response to Diagnose Novel Coronavirus Disease (COVID-19). Humoral response to SARS-CoV-2 can aid to the diagnosis of COVID-19, including subclinical cases. 2020-03-21
Clinical features and treatment of COVID-19 patients in northeast Chongqing. Epidemiological, clinical features, laboratory findings, radiological characteristics, treatment, and clinical outcomes of 135 patients in northeast Chongqing were collected and analyzed in this study. […] Common symptoms included fever (120 [88.9%]), cough (102 [76.5%]), and fatigue (44 [32.5%]). 2020-04-02
Case report of COVID-19 in a kidney transplant recipient: Does immunosuppression alter the clinical presentation? COVID-19 is novel infectious disease with an evolving understanding of its epidemiology and clinical manifestations. […] Herein we report a case of a COVID-19 infection in a solid organ transplant recipient, in which the first clinical symptoms were of gastrointestinal viral disease and fever, which further progressed to respiratory symptoms in 48 hours. 2020-04-10
[When COVID-19 encounters interstitial lung disease: challenges and management]. Clinicians need to comprehensively analyze the epidemic history, disease onset characteristics, clinical manifestations, image characteristics, serological andpathogenic microorganism test results to confirm diagnosis. 2020-03-21
Guide to the Forensic Pathology Practice on Death Cases Related to Corona Virus Disease 2019 (COVID-19) (Trial Draft. Based on related laws and regulations, such as the Law of the People’s Republic of China on Prevention and Control of Infectious Diseases, the clinical manifestations and epidemiological characteristics of COVID-19, and the related guidelines on the prevention and control of the outbreak, combined with the practical work of forensic pathology examination, the Guide to the Forensic Pathology Practice on Death Cases Related to Corona Virus Disease 2019 (COVID-19) (Trial Draft) has been developed. 2020-04-08
The characteristics and clinical value of chest CT images of novel coronavirus pneumonia. To investigate the characteristics and clinical value of chest computed tomography (CT) images of novel coronavirus pneumonia (NCP). […] Clinical data and CT images of 80 cases of NCP were collected. […] The clinical manifestations and laboratory test results of the patients were analysed. […] The main clinical manifestations were fever, dry cough, fatigue, a little white sputum, or diarrhoea. 2020-04-16
[SARS-CoV-2 infection during pregnancy. Information and proposal of management care. CNGOF]. Most often at the origin of a mild infectious syndrome, associating mild symptoms (fever, cough, myalgia, headache and possible digestive disorders) to different degrees, SARS-Covid-2 can cause serious pulmonary pathologies and sometimes death. […] The first Chinese data published seem to show that the symptoms in pregnant women are the same as those of the general population. […] Pregnancy is known as a period at higher risk for the consequences of respiratory infections, as for influenza, so it seems important to screen for Covid-19 in the presence of symptoms and to monitor closely pregnant women. 2020-04-08
Rapid Progression to Acute Respiratory Distress Syndrome: Review of Current Understanding of Critical Illness from COVID-19 Infection. As the clinical spectrum of COVID-19 ranges widely from mild illness to ARDS with a high risk of mortality, there is a need for more research to identify early markers of disease severity. 2020-03-24
COVID-19: gastrointestinal symptoms and potential sources of 2019-nCoV transmission. Infections with the Coronaviridae virus family in a small percentage of patients, especially in those over 60 years of age with a positive clinical history, lead to severe acute respiratory syndrome [2]. 2020-03-23
A review of the 2019 Novel Coronavirus (COVID-19) based on current evidence. Based on the current published evidence, we systematically summarizes the epidemiology, clinical characteristics, diagnosis, treatment and prevention of knowledge surrounding COVID-19. 2020-04-16
COVID-19, cytokines and immunosuppression: what can we learn from severe acute respiratory syndrome? The two previously reported coronavirus epidemics (severe acute respiratory syndrome [SARS] and Middle East respiratory syndrome [MERS]) share similar pathogenetic, epidemiological and clinical features as COVID-19. 2020-04-03
Lopinavir/ritonavir combination therapy amongst symptomatic coronavirus disease 2019 patients in India: Protocol for restricted public health emergency use. Patients will be monitored to document clinical (hospital length of stay and mortality at 14, 28 and 90 days), laboratory (presence of viral RNA in serial throat swab samples) and safety (adverse events and serious adverse events) outcomes. […] Treatment outcomes amongst initial cases would be useful in providing guidance about the clinical management of patients with COVID-19. 2020-03-23
Prudent public health intervention strategies to control the coronavirus disease 2019 transmission in India: A mathematical model-based approach. While there remained important uncertainties in the natural history of COVID-19, using hypothetical epidemic curves, some key findings were illustrated that appeared insensitive to model assumptions, as well as highlighting critical data gaps. :It was assumed that symptomatic quarantine would identify and quarantine 50 per cent of symptomatic individuals within three days of developing symptoms. […] In the pessimistic scenario of R0=4, and asymptomatic infections being half as infectious as symptomatic, this projected impact falls to two per cent. :Port-of-entry-based entry screening of travellers with suggestive clinical features and from COVID-19-affected countries, would achieve modest delays in the introduction of the virus into the community. 2020-03-23
Systematic review of COVID-19 in children shows milder cases and a better prognosis than adults. Data on symptoms and prognosis in children are rare. […] Diagnostic findings have been similar to adults, with fever and respiratory symptoms being prevalent, but fewer children seem to have developed severe pneumonia. 2020-04-14
Urology practice during COVID-19 pandemic. This document could be a valid tool to be used in routine clinical practice and, possibly, a cornerstone for further discussion on the topic also considering the further evolution of the COVID-19 pandemic. 2020-03-23
Factors Associated With Mental Health Outcomes Among Health Care Workers Exposed to Coronavirus Disease 2019. The degree of symptoms of depression, anxiety, insomnia, and distress was assessed by the Chinese versions of the 9-item Patient Health Questionnaire, the 7-item Generalized Anxiety Disorder scale, the 7-item Insomnia Severity Index, and the 22-item Impact of Event Scale-Revised, respectively. […] A considerable proportion of participants reported symptoms of depression (634 [50.4%]), anxiety (560 [44.6%]), insomnia (427 [34.0%]), and distress (899 [71.5%]). […] Nurses, women, frontline health care workers, and those working in Wuhan, China, reported more severe degrees of all measurements of mental health symptoms than other health care workers (eg, median [IQR] Patient Health Questionnaire scores among physicians vs nurses: 4.0 [1.0-7.0] vs 5.0 [2.0-8.0]; P = .007; median [interquartile range {IQR}] Generalized Anxiety Disorder scale scores among men vs women: 2.0 [0-6.0] vs 4.0 [1.0-7.0]; P < .001; median [IQR] Insomnia Severity Index scores among frontline vs second-line workers: 6.0 [2.0-11.0] vs 4.0 [1.0-8.0]; P < .001; median [IQR] Impact of Event Scale-Revised scores among those in Wuhan vs those in Hubei outside Wuhan and those outside Hubei: 21.0 [8.5-34.5] vs 18.0 [6.0-28.0] in Hubei outside Wuhan and 15.0 [4.0-26.0] outside Hubei; P < .001). […] Multivariable logistic regression analysis showed participants from outside Hubei province were associated with lower risk of experiencing symptoms of distress compared with those in Wuhan (odds ratio [OR], 0.62; 95% CI, 0.43-0.88; P = .008). […] Frontline health care workers engaged in direct diagnosis, treatment, and care of patients with COVID-19 were associated with a higher risk of symptoms of depression (OR, 1.52; 95% CI, 1.11-2.09; P = .01), anxiety (OR, 1.57; 95% CI, 1.22-2.02; P < .001), insomnia (OR, 2.97; 95% CI, 1.92-4.60; P < .001), and distress (OR, 1.60; 95% CI, 1.25-2.04; P < .001). 2020-04-01
Should COVID-19 Concern Nephrologists? Why and to What Extent? The Emerging Impasse of Angiotensin Blockade. Lastly, we discuss the clinical management of COVID-19 patients with existing chronic renal disorders, particularly those in dialysis and with kidney transplants. 2020-03-23
The Impact of COVID-19 Epidemic Declaration on Psychological Consequences: A Study on Active Weibo Users. The aim of this study is to explore the impacts of COVID-19 on people’s mental health, to assist policy makers to develop actionable policies, and help clinical practitioners (e.g., social workers, psychiatrists, and psychologists) provide timely services to affected populations. […] It may provide references for policy makers to plan and fight against COVID-19 effectively by improving stability of popular feelings and urgently prepare clinical practitioners to deliver corresponding therapy foundations for the risk groups and affected people. 2020-04-01
Consideration of the respiratory support strategy of severe acute respiratory failure caused by SARS-CoV-2 infection in children. At present there is limited clinical information of the SARS-CoV-2 and there is no specific treatment recommended, although technical guidances and suggestions have been developed and will continue to be updated as additional information becomes available. 2020-03-26
[Perinatal and neonatal management plan for prevention and control of SARS-CoV-2 infection (2nd Edition)]. This plan has been verified by clinical practice for 3 weeks. […] With the further understanding of SARS-CoV-2 infection, especially the emergence of SARS-CoV-2 infection cases in pregnant women and neonates, it is necessary to update the first edition of the management plan so as to offer a better guide on clinical practice. 2020-03-26
[Response plan in the neonatal intensive care unit during epidemic of SARS-CoV-2 infection (2nd Edition)]. Based on the further knowledge and experience on SARS-CoV-2 infection, the neonatologists updated the plan according to the current evidence, so as to provide a better guide for clinical medical staff to deal with the SARS-CoV-2 infection in the NICU. 2020-03-26
[SARS-CoV-2 infection with gastrointestinal symptoms as the first manifestation in a neonate]. Most children with SARS-CoV-2 infection present mainly with respiratory symptoms, but less commonly with gastrointestinal symptoms, and tend to have mild clinical symptoms. 2020-03-26
[Clinical features and chest CT findings of coronavirus disease 2019 in infants and young children]. To study the clinical features and chest CT findings of coronavirus disease 2019 (COVID-19) in infants and young children. […] A retrospective analysis was performed for the clinical data and chest CT images of 9 children, aged 0 to 3 years, who were diagnosed with COVID-19 by nucleic acid detection between January 20 and February 10, 2020. […] Among the 9 children with COVID-19, 5 had no symptoms, 4 had fever, 2 had cough, and 1 had rhinorrhea. […] There were only symptoms of the respiratory system. […] Infants and young children with COVID-19 tend to have mild clinical symptoms and imaging findings not as typical as those of adults, and therefore, the diagnosis of COVID-19 should be made based on imaging findings along with epidemiological history and nucleic acid detection. 2020-03-26
[Twin girls infected with SARS-CoV-2]. The two girls had mild symptoms and rapid recovery, suggesting that children with SARS-CoV-2 infection may be mild and have a good prognosis. […] There were differences in the clinical symptoms and imaging findings between the twin girls, suggesting that SARS-CoV-2 infection has diverse clinical features in children. 2020-03-26
Hydroxychloroquine and azithromycin as a treatment of COVID-19: results of an open-label non-randomized clinical trial. Depending on their clinical presentation, azithromycin was added to the treatment. […] Six patients were asymptomatic, 22 had upper respiratory tract infection symptoms and eight had lower respiratory tract infection symptoms. 2020-04-01
Epidemiological, clinical characteristics of cases of SARS-CoV-2 infection with abnormal imaging findings. To investigate the epidemiological, clinical characteristics of COVID-19 patients with abnormal imaging findings. […] Epidemiological, clinical data were analyzed between those with abnormal or normal imaging findings. […] Patients with abnormal images have more obvious clinical manifestations and laboratory changes. […] Combing clinical features and radiograph score can effectively predict severe/critical type. 2020-03-24
Updated approaches against SARS-CoV-2. There is a growing understanding of SARS-CoV-2 in the virology, epidemiology and clinical management strategies. […] Recent studies have revealed many attractive threptic options, even if some of them remain to be further confirmed in rigorous preclinical models and clinical trials. 2020-03-24
Clinical Characteristics of Children with Coronavirus Disease 2019 in Hubei, China. Despite the rapidly increasing number of cases in subsequent weeks, the clinical characteristics of pediatric cases are rarely described. […] The demographic data, epidemiological history, underlying diseases, clinical manifestations, laboratory and radiological data, treatments, and outcomes were analyzed. […] The most common symptoms at onset of illness were fever (13 [52%]), and dry cough (11 [44%]). […] Clinical diagnoses included upper respiratory tract infection (n=8), mild pneumonia (n=15), and critical cases (n=2). […] The symptoms in 24 (96%) of 25 patients were alleviated and one patient had been discharged. […] It was concluded that children were susceptible to COVID-19 like adults, while the clinical presentations and outcomes were more favorable in children. 2020-03-24
How to perform lung ultrasound in pregnant women with suspected COVID-19 infection. Under specific circumstances, such as during the current COVID-19 outbreak, pregnant women can be a target for respiratory infection, and lung examination may be required as part of their clinical evaluation, ideally avoiding exposure to radiation. 2020-03-24
Action at a Distance: Geriatric Research during a Pandemic. “Action at a distance” may be the new norm for clinical researchers in the context of the COVID-19 pandemic that may require social distancing for the next 18 months. […] Clinical researchers have an obligation to help, and we can. […] Recommendations for clinical researchers working with older adults during the COVID-19 pandemic are discussed. […] Mobilize research platforms for patient needs: Leverage our relationships with participants and rapidly deploy novel clinical engagement techniques such as digital tools to intervene remotely and reduce the negative effects of social isolation on our participants. […] Above all, clinical researchers need to continue working, to help as many people as possible through the crisis. 2020-04-03
[CT imaging features of patients with different clinical types of coronavirus disease 2019 (COVID-19)]. To analyze the CT findings of patients with different clinical types of coronavirus disease 2019 (COVID-19). […] A total of 67 patients diagnosed as COVID-19 by nucleic acid testing were included and divided into 4 groups according to the clinical staging based on Diagnosis and treatment of novel coronavirus pneumonia (Trial version 6). […] The CT imaging characteristics were analyzed among patients with different clinical types. […] CT images in patients with different clinical types of COVID-19 have characteristic manifestations, and solid shadow may predict severe and critical illness. 2020-03-26
The Battle Against Coronavirus Disease 2019 (COVID-19): Emergency Management and Infection Control in a Radiology Department. The team formulated various measures: reconfiguration of the radiology department, personal protection and training of staff, examination procedures for patients suspected of or confirmed with COVID-19 as well as patients without an exposure history or symptoms. 2020-04-13
Rapid Response to COVID-19: Health Informatics Support for Outbreak Management in an Academic Health System. To describe the implementation of technological support important for optimizing clinical management of the COVID-19 pandemic. […] An Incident Command Center was established early in the crisis and helped identify electronic health record (EHR) based tools to support clinical care. […] We outline the design and implementation of EHR based rapid screening processes, laboratory testing, clinical decision support, reporting tools, and patient-facing technology related to COVID-19. […] The EHR is an essential tool in supporting the clinical needs of a health system managing the COVID-19 pandemic. 2020-03-25
Clinical observation and management of COVID-19 patients. He depicts the clinical course of SARS-CoV-2 infection. […] Professor Hongzhou Lu, a leader in China to try various anti-viral drugs, expresses concern on the quality of the ongoing clinical trials as most trials are small in scale and repetitive in nature, and emphasizes the importance of the quick publication of clinical trial results. […] Professor Wenhong Zhang is responsible for Shanghai’s overall clinical management of the COVID-19 cases. 2020-04-07
The different clinical characteristics of corona virus disease cases between children and their families in China - the character of children with COVID-19. This study aims to analyze the different clinical characteristics between children and their families infected with severe acute respiratory syndrome coronavirus 2. […] Clinical data from nine children and their 14 families were collected, including general status, clinical, laboratory test, and imaging characteristics. […] Three children had fever (22.2%) or cough (11.2%) symptoms and six (66.7%) children had no symptom. […] Among the 14 adult patients, the major symptoms included fever (57.1%), cough (35.7%), chest tightness/pain (21.4%), fatigue (21.4%) and sore throat (7.1%). […] COVID-19 in children is mainly caused by family transmission, and their symptoms are mild and prognosis is better than adult. […] Because of the mild or asymptomatic clinical process, it is difficult to recognize early for pediatrician and public health staff. 2020-04-07
Serological and molecular findings during SARS-CoV-2 infection: the first case study in Finland, January to February 2020. We describe the clinical picture and laboratory findings 3-23 days since the first symptoms. 2020-04-02
Clinical characteristics of fatal and recovered cases of coronavirus disease 2019 (COVID-19) in Wuhan, China: a retrospective study. This study is performed to analyze the clinical characteristics of patients who succumbed to and who recovered from 2019 novel coronavirus disease (COVID-19). […] Clinical data were collected from two tertiary hospitals in Wuhan. […] A retrospective investigation was conducted to analyze the clinical characteristics of fatal cases of COVID-19 (death group) and compare them with recovered patients (recovered group). […] On admission, the proportion of patients with symptoms of dyspnea (70.6% vs. 2020-03-26
Epidemiological data from the COVID-19 outbreak, real-time case information. All data are geo-coded and, where available, include symptoms, key dates (date of onset, admission, and confirmation), and travel history. 2020-04-01
Epidemiological and Clinical Predictors of COVID-19. Rapid identification of COVID-19 cases, which is crucial to outbreak containment efforts, is challenging due to the lack of pathognomonic symptoms and in settings with limited capacity for specialized nucleic acid-based reverse transcription polymerase chain reaction (PCR) testing. […] Demographic, clinical, laboratory and exposure-risk variables ascertainable at presentation were analyzed to develop an algorithm for estimating the risk of COVID-19. […] Using leave-out-one cross validation, all the models incorporating clinical tests (Models 1, 2 and 3) performed well with areas under the receiver operating characteristics curve (AUC) of 0.91, 0.88 and 0.88 respectively. […] Rapidly ascertainable clinical and laboratory data could identify individuals at high risk of COVID-19 and enable prioritization of PCR-testing and containment efforts. 2020-03-26
Inflammatory bowel disease care in the COVID-19 pandemic era: the Humanitas, Milan experience. Fever, chills, cough, shortness of breath, generalized myalgia, malaise, drowsy, diarrhoea, confusion, dyspnoea, and bilateral interstitial pneumonia are the common symptoms. 2020-03-26
Association of Cardiac Injury With Mortality in Hospitalized Patients With COVID-19 in Wuhan, China. Clinical laboratory, radiological, and treatment data were collected and analyzed. […] Common symptoms included fever (334 patients [80.3%]), cough (144 [34.6%]), and shortness of breath (117 [28.1%]). 2020-03-28
Analysis of Epidemiological and Clinical features in older patients with Corona Virus Disease 2019 (COVID-19) out of Wuhan. This study aimed to investigate the epidemiological and clinical characteristics of older patients with COVID-19 out of Wuhan. […] A retrospective study was performed, with collecting data from medical records of confirmed COVID-19 patients in Zhejiang province from Jan 17 to Feb 12, 2020. […] Epidemiological, clinical and treatment data were analyzed between those older (≥60y) and younger (<60y) patients. […] The specific epidemiological and clinical features of older COVID-19 patients included significantly higher female gender, body temperature, co-existing of basic diseases and rate of severe and critical type. 2020-03-26
Coronavirus disease 2019 (COVID-19): update for anesthesiologists and intensivists March 2020. Unlike other acute infectious diseases progressing to sepsis, the severe courses of COVID19 seemingly show prolonged progression from onset of first symptoms to life-threatening deterioration of (primarily) lung function. 2020-03-26
Coronavirus disease 2019: initial chest CT findings. Patients were assigned to the early-stage group (onset of symptoms within 4 days) or progressive-stage group (onset of symptoms within 4-7 days) for analysis. 2020-03-30
COVID-19 containment: China provides important lessons for global response. We summarized the effective intervention and prevention measures in the fields of public health response, clinical management, and research development in China, which may provide vital lessons for the global response. 2020-03-26
Ethics of Conducting Clinical Research in an Outbreak Setting. The conduct of clinical trials during the West Africa Ebola outbreak in 2014 highlighted many ethical challenges. […] How these challenges were addressed, what clinical studies were conducted during that outbreak, and the lessons learned for dealing with future outbreaks were the subject of a National Academy of Medicine committee report titled Integrating Clinical Research into Epidemic Response: The Ebola Experience. […] We also discuss the current Ebola outbreak in the Democratic Republic of the Congo and highlight how the dialogue has changed and how successful clinical trials have been implemented. 2020-03-28
Pharmacologic Treatments and Supportive Care for Middle East Respiratory Syndrome. Clinical trials are needed to guide treatment decisions. 2020-03-27
Epidemiological, clinical and virological characteristics of 74 cases of coronavirus-infected disease 2019 (COVID-19) with gastrointestinal symptoms. Previous studies mainly focused on Wuhan and typical symptoms. […] We analysed 74 confirmed COVID-19 cases with GI symptoms in the Zhejiang province to determine epidemiological, clinical and virological characteristics. […] Epidemiological, demographic, clinical, laboratory, management and outcome data of patients with GI symptoms were analysed using multivariate analysis for risk of severe/critical type. […] Of patients with COVID-19 with GI symptoms, 17 (22.97%) and 23 (31.08%) had severe/critical types and family clustering, respectively, significantly higher than those without GI symptoms, 47 (8.14%) and 118 (20.45%). […] Of patients with COVID-19 with GI symptoms, 29 (39.19%), 23 (31.08%), 8 (10.81%) and 16 (21.62%) had significantly higher rates of fever >38.5°C, fatigue, shortness of breath and headache, respectively. […] We report COVID-19 cases with GI symptoms with novel features outside Wuhan. […] Attention to patients with COVID-19 with non-classic symptoms should increase to protect health providers. 2020-04-08
The effect of human mobility and control measures on the COVID-19 epidemic in China. Major behavioral, clinical, and state interventions have been undertaken to mitigate the epidemic and prevent the persistence of the virus in human populations in China and worldwide. 2020-03-27
Italy in a Time of Emergency and Scarce Resources: The Need for Embedding Ethical Reflection in Social and Clinical Settings. This brief contribution aims to offer a reflection on the public and clinical role of the bioethicist: a figure able to promote dialogue between the world of medicine and the community, and to face ethical dilemmas even in emergent clinical settings. 2020-04-02
Coronavirus Disease 2019 (COVID-19) and Pregnancy: Responding to a Rapidly Evolving Situation. Prenatal clinics should ensure all pregnant women and their visitors are screened for fever and respiratory symptoms, and symptomatic women should be isolated from well women and required to wear a mask. 2020-04-16
Expanded Umbilical Cord Mesenchymal Stem Cells (UC-MSCs) as a Therapeutic Strategy in Managing Critically Ill COVID-19 Patients: The Case for Compassionate Use. The clinical spectrum of COVID-19 varies from asymptomatic forms to conditions encompassing multiorgan and systemic manifestations in terms of septic shock, and multiple organ dysfunction (MOD) syndromes. […] In this manuscript, we describe the urgent need for various solutions, pathogenesis of coronavirus and the clinical evidence for treatment of COVID-19 with stem cells. 2020-04-01
Is There an Association Between COVID-19 Mortality and the Renin-Angiotensin System-a Call for Epidemiologic Investigations. With conflicting mechanistic evidence, we propose key clinical research priorities necessary to clarify the role of RAS inhibition in COVID-19 mortality that could be rapidly addressed by the international research community. 2020-04-14
Simulation of the clinical and pathological manifestations of Coronavirus Disease 2019 (COVID-19) in golden Syrian hamster model: implications for disease pathogenesis and transmissibility. Maximal clinical signs of rapid breathing, weight loss, histopathological changes from the initial exudative phase of diffuse alveolar damage with extensive apoptosis to the later proliferative phase of tissue repair, airway and intestinal involvement with virus nucleocapsid protein expression, high lung viral load, and spleen and lymphoid atrophy associated with marked cytokine activation were observed within the first week of virus challenge. 2020-03-27
CT image visual quantitative evaluation and clinical classification of coronavirus disease (COVID-19). To explore the relationship between the imaging manifestations and clinical classification of COVID-19. […] Patients were divided into 3 types based on Chinese guideline: mild (patients with minimal symptoms and negative CT findings), common, and severe-critical (patients with positive CT findings and different extent of clinical manifestations). […] The TSS was compared with the clinical classification. […] The proportion of clinical mild-type patients with COVID-19 was relatively high; CT was not suitable for independent screening tool. […] The CT visual quantitative analysis has high consistency and can reflect the clinical classification of COVID-19. 2020-03-30
Tilorone: a Broad-Spectrum Antiviral Invented in the USA and Commercialized in Russia and beyond. Over the years there have been numerous clinical and non-clinical reports of its broad spectrum of antiviral activity. 2020-04-01
[The Covid-19 pandemic and otolaryngology: What it comes down to?] We discuss the clinical management of all ENT patients, but especially of COVID-19 patients from the ENT perspective. 2020-03-27
Covid-19 and the Digestive System. While patients typically present with fever and a respiratory illness, some patients also report gastrointestinal symptoms such as diarrhoea, vomiting and abdominal pain. […] This has important implications to the disease management, transmission, and infection control. 2020-03-27
Novel coronavirus and central nervous system. Clinical characteristics of 2019-nCoV that respiratory symptoms, such as cough, are the most common.[ 2020-03-27
Elevated Plasmin(ogen) as a Common Risk Factor for COVID-19 Susceptibility. Patients with hypertension, diabetes, coronary heart disease, cerebrovascular illness, chronic obstructive pulmonary disease, and kidney dysfunction have worse clinical outcomes when infected with SARS-CoV-2, for unknown reasons. 2020-04-10
Analysis of clinical characteristics and laboratory findings of 95 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a retrospective analysis. We sought to analyse the clinical characteristics and laboratory findings of some cases with 2019 novel coronavirus pneumonia . 2020-04-01
Imaging manifestations and diagnostic value of chest CT of coronavirus disease 2019 (COVID-19) in the Xiaogan area. To report the epidemiological, clinical, and radiological characteristics of patients with COVID-19 in Xiaogan, Hubei, China. […] The complete clinical and imaging data of 114 confirmed COVID-19 patients treated in Xiaogan Hospital were analysed retrospectively. 2020-04-10
Coronavirus Disease 2019 (COVID-19) Pandemic and Pregnancy. The SARS-CoV-2 virus has been isolated from asymptomatic individuals, and affected patients continue to be infectious two weeks after cessation of symptoms. […] Our clinical service model is built around the principles of workplace segregation, responsible social distancing, containment of cross-infection to healthcare providers, judicious use of personal protective equipment and telemedicine. 2020-03-28
COVID-19: Melatonin as a potential adjuvant treatment. Based on clinical features, pathology, the pathogenesis of acute respiratory disorder induced by either highly homogenous coronaviruses or other pathogens, the evidence suggests that excessive inflammation, oxidation, and an exaggerated immune response very likely contribute to COVID-19 pathology. […] Melatonin is effective in critical care patients by reducing vessel permeability, anxiety, sedation use, and improving sleeping quality, which might also be beneficial for better clinical outcomes for COVID-19 patients. […] Additional experiments and clinical studies are required to confirm this speculation. 2020-04-16
Clinical characteristics of 113 deceased patients with coronavirus disease 2019: retrospective study. To delineate the clinical characteristics of patients with coronavirus disease 2019 (covid-19) who died. […] Clinical characteristics and laboratory findings were obtained from electronic medical records with data collection forms. 2020-04-06
Comorbidity and its impact on 1590 patients with Covid-19 in China: A Nationwide Analysis. Among laboratory-confirmed cases of Covid-19, patients with any comorbidity yielded poorer clinical outcomes than those without. […] A greater number of comorbidities also correlated with poorer clinical outcomes. 2020-03-31
SARS-CoV-2: a storm is raging. In this issue of the JCI, Chen and colleagues compared the clinical and immunological characteristics between moderate and severe COVID-19. 2020-04-13
Clinical and immunological features of severe and moderate coronavirus disease 2019. METHODSIn this retrospective study, the clinical and immunological characteristics of 21 patients (17 male and 4 female) with COVID-19 were analyzed. […] Common clinical manifestations included fever, cough, and fatigue. 2020-04-13
High-Resolution Computed Tomography Manifestations of 5 Pediatric Patients With 2019 Novel Coronavirus. We present clinical and chest computed tomography (CT) features of 5 cases of pediatric patients with 2019 novel coronavirus. 2020-03-28
National Institute for the Infectious Diseases “L. Spallanzani”, IRCCS. Recommendations for COVID-19 clinical management. Hereby, we show our recommendations for the management of COVID-19 patients, based on very limited clinical evidences; they should be considered as expert opinions, which may be modified according to newly produced literature data. 2020-03-31
Modeling the epidemic dynamics and control of COVID-19 outbreak in China. The confirmation rate of Wuhan estimated by our model is 0.0643, substantially lower than that of Hubei excluding Wuhan (0.1914), and that of China excluding Hubei (0.2189), but it jumps to 0.3229 after February 12 when clinical evidence was adopted in new diagnosis guidelines. 2020-03-31
Cardiac Involvement in a Patient With Coronavirus Disease 2019 (COVID-19). To describe the presentation of acute myocardial inflammation in a patient with coronavirus disease 2019 (COVID-19) who recovered from the influenzalike syndrome and developed fatigue and signs and symptoms of heart failure a week after upper respiratory tract symptoms. […] The patient did not show any respiratory involvement during the clinical course. […] She was treated with dobutamine, antiviral drugs (lopinavir/ritonavir), steroids, chloroquine, and medical treatment for heart failure, with progressive clinical and instrumental stabilization. […] This case highlights cardiac involvement as a complication associated with COVID-19, even without symptoms and signs of interstitial pneumonia. 2020-03-28
Treatment of 5 Critically Ill Patients With COVID-19 With Convalescent Plasma. Clinical outcomes were compared before and after convalescent plasma transfusion. […] In this preliminary uncontrolled case series of 5 critically ill patients with COVID-19 and ARDS, administration of convalescent plasma containing neutralizing antibody was followed by improvement in their clinical status. […] The limited sample size and study design preclude a definitive statement about the potential effectiveness of this treatment, and these observations require evaluation in clinical trials. 2020-03-31
Experience of Clinical Management for Pregnant Women and Newborns with Novel Coronavirus Pneumonia in Tongji Hospital, China. Based on the New Diagnosis and Treatment Scheme for Novel Coronavirus Infected Pneumonia (Trial Edition 5), combined with our current clinical treatment experience, we recently proposed a revision of the first edition of “Guidance for maternal and fetal management during pneumonia epidemics of novel coronavirus infection in the Wuhan Tongji Hospital”. 2020-03-28
[Expert consensus on the management strategy of patients with hereditary ataxia during prevention and control of novel coronavirus pneumonia epidemic]. Patients with central nervous system involvement may show a series of neurological symptoms, which is easy to be misdiagnosed and neglected, thereby increasing the risk of SARS-CoV-2 transmission. […] Hereditary ataxia is a large group of neurodegenerative diseases with great clinical and genetic heterogeneity and high mortality and disability. 2020-04-02
Stability issues of RT-PCR testing of SARS-CoV-2 for hospitalized patients clinically diagnosed with COVID-19. Our results indicate that in addition to the emphasis on RT-PCR testing, clinical indicators such as computed tomography images should also be used not only for diagnosis and treatment but also for isolation, recovery/discharge, and transferring for hospitalized patients clinically diagnosed with COVID-19 during the current epidemic. 2020-04-05
Early antiviral treatment contributes to alleviate the severity and improve the prognosis of patients with novel coronavirus disease (COVID-19). To assess the factors associated with severity and prognosis of patients infected with SARS-CoV-2, we retrospectively investigated the clinical, imaging, and laboratory characteristics of confirmed 280 cases of novel coronavirus disease (COVID-19) from January 20 to February 20, 2020. 2020-03-28
[Epidemiology, Treatment, and Epidemic Prevention and Control of the Coronavirus Disease 2019: a Review]. The main clinical symptoms of the patients are fever and cough, accompanied with leukocytopenia and lymphocytopenia. 2020-04-02
[Oral Health Management of Children during the Epidemic Period of Coronavirus Disease 2019]. If non-emergency oral situation occur, parents could assist their child to take home based care such as rinsing to relieve the symptoms. 2020-04-02
[Clinical Study and CT Findings of a Familial Cluster of Pneumonia with Coronavirus Disease 2019 (COVID-19)]. We studied the epidemiological and clinical data collected from a family with 5 people, in which there were 3 family member diagnosed as coronavirus disease 2019 (COVID-19). […] The most common symptoms were fever, cough and weakness. […] The epidemiological and clinical features could provide quicker diagnosis and better management for the COVID-19 infected patients. 2020-04-02
Epidemiology of Covid-19 in a Long-Term Care Facility in King County, Washington. Most cases among residents included respiratory illness consistent with Covid-19; however, in 7 residents no symptoms were documented. 2020-04-07
[Clinical and coagulation characteristics of 7 patients with critical COVID-2019 pneumonia and acro-ischemia]. Objective: To investigate the clinical and coagulation characteristics of the critical Coronavirus disease 2019 (COVID-19) patients with acro-ischemia in the intensive care unit (ICU). Methods: The retrospective study included 7 critical COVID-19 patients with acro-ischemia in a single center in Wuhan, from Feb 4 to Feb 15, 2020. […] The clinical and laboratory data before and during the ICU stay were analyzed. Results: The median age of 7 patients was 59 years and 4 of them were men. 3 of them were associated with underlying comorbidities. […] Fever, cough, dyspnea and diarrhea were common clinical symptoms. […] D-dimer and FDP levels increased progressively when COVID-2019 exacerbated, and 4 patients were diagnosed with definite disseminated intravascular coagulation (DIC). 6 patients received low molecular weight heparin (LMWH) treatment, after which their D-dimer and FDP decreased, but there was no significant improvement in clinical symptoms. 5 patients died finally and the median time from acro-ischemia to death was 12 days. Conclusions: The existence of hypercoagulation status in critical COVID-2019 patients should be monitored closely, and anticoagulation therapy can be considered in selected patients. […] More clinical data is needed to investigate the role of anticoagulation in COVID-2019 treatment. 目的: 总结合并肢端缺血的新型冠状病毒肺炎(COVID-19)患者的临床和凝血参数特征。 2020-03-29
Clinical features and obstetric and neonatal outcomes of pregnant patients with COVID-19 in Wuhan, China: a retrospective, single-centre, descriptive study. The number of affected pregnant women is increasing, but scarce information is available about the clinical features of COVID-19 in pregnancy. […] This study aimed to clarify the clinical features and obstetric and neonatal outcomes of pregnant patients with COVID-19. […] Clinical features, treatments, and maternal and fetal outcomes were assessed. […] Clinical manifestations were fever (six [86%] patients), cough (one [14%] patient), shortness of breath (one [14%] patient), and diarrhoea (one [14%] patient). […] All the patients had caesarean section within 3 days of clinical presentation with an average gestational age of 39 weeks plus 2 days. […] The clinical characteristics of these patients with COVID-19 during pregnancy were similar to those of non-pregnant adults with COVID-19 that have been reported in the literature. 2020-04-16
Anesthetic Management of Patients Undergoing Aortic Dissection Repair With Suspected Severe Acute Respiratory Syndrome Coronavirus-2 Infection. The purpose of the present report is to summarize current knowledge and experiences on anesthetic management in this patient population and to provide clinical practice guidelines on anesthetic management and infection prevention and control in these critically ill patients. 2020-04-01
Featuring COVID-19 cases via screening symptomatic patients with epidemiologic link during flu season in a medical center of central Taiwan. We retrospectively analyzed the clinical presentations, laboratory data, radiologic findings, and travel and exposure contact histories, of the COVID-19 patients in comparison to those with other respiratory infections. […] Since all patients shared similar clinical and laboratory findings, expanded surveillance of detailed exposure history for suspected patients and application of rapid detection tools are highly recommended. 2020-04-01
Clinical and epidemiological features of 36 children with coronavirus disease 2019 (COVID-19) in Zhejiang, China: an observational cohort study. Little is known about the epidemiological and clinical features of paediatric patients with COVID-19. […] We retrospectively retrieved data for paediatric patients (aged 0-16 years) with confirmed COVID-19 from electronic medical records in three hospitals in Zhejiang, China. […] We recorded patients’ epidemiological and clinical features. […] The route of transmission was by close contact with family members (32 [89%]) or a history of exposure to the epidemic area (12 [33%]); eight (22%) patients had both exposures. 19 (53%) patients had moderate clinical type with pneumonia; 17 (47%) had mild clinical type and either were asymptomatic (ten [28%]) or had acute upper respiratory symptoms (seven [19%]). […] Common symptoms on admission were fever (13 [36%]) and dry cough (seven [19%]). […] Ningbo Clinical Research Center for Children’s Health and Diseases, Ningbo Reproductive Medicine Centre, and Key Scientific and Technological Innovation Projects of Wenzhou. 2020-04-16
Antibody responses to SARS-CoV-2 in patients of novel coronavirus disease 2019. The antibody response in infected patient remains largely unknown, and the clinical values of antibody testing have not been fully demonstrated. […] Moreover, a higher titer of Ab was independently associated with a worse clinical classification (p=0.006). […] The antibody detection offers vital clinical information during the course of SARS-CoV-2 infection. 2020-03-29
Quantitative Detection and Viral Load Analysis of SARS-CoV-2 in Infected Patients. The widely used reverse transcription PCR (RT-PCR) method has limitations for clinical diagnosis and treatment. […] Clinical and imaging data were obtained for clinical staging. 2020-03-29
Use of in situ simulation to evaluate the operational readiness of a high-consequence infectious disease intensive care unit. We recommend that staff working in clinical areas expected to receive patients with COVID-19 conduct in-situ simulation in order to detect their own unique risks and aid in the creation of local guidelines of management of patients with COVID-19. 2020-03-31
The Italian coronavirus disease 2019 outbreak: recommendations from clinical practice. Clinical data from the Chinese outbreak have been reported, but experiences and recommendations from clinical practice during the Italian outbreak have not. […] We also report on recommendations based on clinical experiences of managing patients throughout Italy. […] In particular, we describe key elements of clinical management, including: safe oxygen therapy; airway management; personal protective equipment; and non-technical aspects of caring for patients diagnosed with coronavirus disease 2019. 2020-04-01
Organ-protective effect of angiotensin-converting enzyme 2 and its effect on the prognosis of COVID-19. Acute respiratory distress syndrome (ARDS) is a clinical high-mortality disease, and ACE2 has a protective effect on this type of acute lung injury. 2020-04-05
Clinical analysis of pregnant women with 2019 novel coronavirus pneumonia. The aim is to evaluate pregnant women infected with coronavirus disease 2019 (COVID-19) and provide help for clinical prevention and treatment. […] Their primary initial manifestations were merely low-grade postpartum fever or mild respiratory symptoms. 2020-04-10
[Management of a colon cancer patient infected with corona virus disease 2019]. The management and clinical outcome of a sigmoid cancer patient with COVID-19 were analyzed. 2020-04-01
[Follow-up testing of viral nucleic acid in discharged patients with moderate type of 2019 coronavirus disease (COVID-19)]. To investigate the clinical outcome of patients with moderate type of corona virus disease 2019 (COVID-19) after discharge by retesting viral nucleic acid. […] During the three weeks of quarantined period, the symptoms and signs were documented; and sputum or nasal swab and feces samples were collected to test SARS-COV-2 nucleic acid by RT-PCR method. […] There were no symptoms and signs during the quarantine period in all 7 patients. 2020-04-01
The use of anti-inflammatory drugs in the treatment of people with severe coronavirus disease 2019 (COVID-19): The Perspectives of clinical immunologists from China. In the past two months, we clinical immunologists participated in multi-rounds of MDT (multidiscipline team) discussion on the anti-inflammation management of critical COVID-19 patients, with our colleagues dispatched from Chinese leading PUMC Hospital to Wuhan to admit and treat the most severe patients. […] Here, from the perspective of clinical immunologists, we will discuss the clinical and immunological characteristics of severe patients, and summarize the current evidence and share our experience in anti-inflammation treatment, including glucocorticoids, IL-6 antagonist, JAK inhibitors and choloroquine/hydrocholoroquine, of patients with severe COVID-19 that may have an impaired immune system. 2020-04-16
COVID-19 Infection in a Patient with End-Stage Kidney Disease. With the control of uremia and fluid status, this patient ended up with an uneventful post-CRRT course, absence of clinical symptoms, and negative PCR tests. 2020-03-30
A Case of Novel Coronavirus Disease 19 in a Chronic Hemodialysis Patient Presenting with Gastroenteritis and Developing Severe Pulmonary Disease. During this interval, he reported nausea, vomiting, diarrhea, and low-grade fevers but was not suspected of COVID-19 infection until he developed respiratory symptoms and was admitted to the hospital. 2020-03-30
Advice on Standardized Diagnosis and Treatment for Spinal Diseases during the Coronavirus Disease 2019 Pandemic. Coronavirus disease 2019 (COVID-19) outbreak started in December 2019 that caused difficulties for clinical work. 2020-04-07
Providing pharmacy services during the coronavirus pandemic. Chinese pharmacists have acted swiftly in the public health response in China, such as drafting professional service guidance to pharmacists and pharmacies, establishing emergency drug formularies, monitoring and resolving drug shortages, establishing remote pharmacy services to prevent human-to-human infections, providing event-driven pharmaceutical care, educating the public on infection prevention and disease management, and participating in clinical trials and drug evaluation. 2020-04-02
Clinical characteristics of 54 medical staff with COVID-19: A retrospective study in a single center in Wuhan, China. Clinical and epidemiological characteristics were compared between different groups by statistical method. […] Most of them were from other clinical departments (72.2%) rather than emergency department (3.7%) or medical technology departments (18.5%). […] However, there was no statistical difference in terms of gender distribution and the first symptoms between theses two groups. 2020-04-07
Review article: gastrointestinal features in COVID-19 and the possibility of faecal transmission. We have reviewed gastrointestinal features of, and faecal test results in, COVID-19 from case reports and retrospective clinical studies relating to the digestive system published since the outbreak. […] With an incidence of 3% (1/41)-79% (159/201), gastrointestinal symptoms of COVID-19 included anorexia 39.9% (55/138)-50.2% (101/201), diarrhoea 2% (2/99)-49.5% (146/295), vomiting 3.6% (5/138)-66.7% (4/6), nausea 1% (1/99)-29.4% (59/201), abdominal pain 2.2% (3/138)-6.0% (12/201) and gastrointestinal bleeding 4% (2/52)-13.7% (10/73). […] Adult and children patients can present with digestive symptoms in the absence of respiratory symptoms. […] The incidence of digestive manifestations was higher in the later than in the early stage of the epidemic, but no differences in digestive symptoms among different regions were found. […] Among the group of patients with a higher proportion of severe cases, the proportion of gastrointestinal symptoms in severe patients was higher than that in nonsevere patients (anorexia 66.7% vs 30.4%; abdominal pain 8.3% vs 0%); while in the group of patients with a lower severe rate, the proportion with gastrointestinal symptoms was similar in severe and nonsevere cases (nausea and vomiting 6.9% vs 4.6%; diarrhoea 5.8% vs 3.5%). […] Gastrointestinal symptoms are common in patients with COVID-19, and had an increased prevalence in the later stage of the recent epidemic in China. 2020-04-16
Sixty-eight consecutive patients assessed for COVID-19 infection: Experience from a UK Regional infectious diseases Unit. Between 29 January 2020 and 24 February 2020, demographic, clinical, epidemiological and laboratory data were collected. […] We compared clinical features between patients not requiring admission for clinical reasons or antimicrobials with those assessed as needing either admission or antimicrobial treatment. […] Peaks of clinical assessments coincided with updates to the case definition for suspected COVID-19. […] Patients requiring admission on clinical grounds or antimicrobials (14/68) were more likely to have fever or raised respiratory rate compared to those not requiring admission or antimicrobials. […] The majority of patients had mild illness, which did not require clinical intervention. 2020-04-08
Preliminary Results of Initial Testing for Coronavirus (COVID-19) in the Emergency Department. Data collected from patients who were tested included demographics, clinical characteristics, and test qualifying criteria. […] Symptoms-based criteria most associated with COVID-19 were the most common criteria identified for testing (90.6%). 2020-04-01
Comparison of Hospitalized Patients With ARDS Caused by COVID-19 and H1N1. The aim of this study was to explore the different clinical presentations between COVID-19 and influenza A (H1N1) pneumonia in patients with ARDS. […] Their clinical manifestations, imaging characteristics, treatments, and prognosis were analyzed and compared. […] Patients with COVID-19 exhibited higher proportions of nonproductive coughs, fatigue, and GI symptoms than those of patients with H1N1 (P < .05). […] There were many differences in clinical presentations between patients with ARDS infected with either COVID-19 or H1N1. 2020-04-14
How to link patients with suspicious COVID-19 to health system from the community pharmacies? A route proposal. In the route have been considered three possible entrances depending on the needs of the users: anti-flu drugs, symptoms related to COVID-19 infection or the request for items for hygiene and prevention of transmission such as alcohol and face masks. 2020-04-16
Clinical characteristics of COVID-19-infected cancer patients: A retrospective case study in three hospitals within Wuhan, China. To date, the clinical characteristics of COVID-19-infected cancer patients are largely unknown. […] The clinical data were collected from medical records from Jan 13, 2020, to Feb 26, 2020. […] The following clinical features were shown in our cohort: fever (23, 82.1%), dry cough (22, 81%) and dyspnoea (14, 50.0%), along with lymphopaenia (23, 82.1%), high level of high-sensitivity C-reactive protein (23, 82.1%), anaemia (21, 75.0%) and hypoproteinaemia (25, 89.3%). 2020-03-31
Clinical and virological data of the first cases of COVID-19 in Europe: a case series. We assessed patterns of clinical disease and viral load from different samples (nasopharyngeal and blood, urine, and stool samples), which were obtained once daily for 3 days from hospital admission, and once every 2 or 3 days until patient discharge. […] Three different clinical evolutions are described: (1) two paucisymptomatic women diagnosed within a day of exhibiting symptoms, with high nasopharyngeal titres of SARS-CoV-2 within the first 24 h of the illness onset (5·2 and 7·4 log10 copies per 1000 cells, respectively) and viral RNA detection in stools; (2) a two-step disease progression in two young men, with a secondary worsening around 10 days after disease onset despite a decreasing viral load in nasopharyngeal samples; and (3) an 80-year-old man with a rapid evolution towards multiple organ failure and a persistent high viral load in lower and upper respiratory tract with systemic virus dissemination and virus detection in plasma. […] We illustrated three different clinical and biological types of evolution in five patients infected with SARS-CoV-2 with detailed and comprehensive viral sampling strategy. 2020-04-16
Pathways for urology patients during the COVID-19 pandemic. The public health emergency caused by the Coronavirus Disease 2019 (COVID-19) pandemic has resulted in a significant reallocation of health resources with a consequent reorganization of the clinical activities also in several urological centers. […] In absence of strict uniform regulations that impose the implementation of nasopharyngeal swabs, we recommend that an accurate triage for possible COVID-19 symptoms be performed both by telephone at home before hospitalization and at the time of hospitalization. 2020-03-31
SARS-CoV-2: an Emerging Coronavirus that Causes a Global Threat. In this review, we summarize the key events occurred during the early stage of SARS-CoV-2 outbreak, the basic characteristics of the pathogen, the signs and symptoms of the infected patients as well as the possible transmission pathways of the virus. 2020-04-03
Evaluation of SARS-CoV-2 RNA shedding in clinical specimens and clinical characteristics of 10 patients with COVID-19 in Macau. In this study, we report clinical and microbiological features of ten COVID-19 patients enrolled in the Centro Hospitalar Conde de São Januário (CHCSJ) between January 21 to February 16, 2020. […] Clinical samples from all patients including nasopharyngeal swab (NPS)/sputum, urine, and feces were collected for serial virus RNA testing by standard qRT-PCR assay. […] The most common symptoms were fever (80%) and diarrhea (80%). 2020-04-03
Traditional Chinese Medicine in the Treatment of Patients Infected with 2019-New Coronavirus (SARS-CoV-2): A Review and Perspective. The supportive care and non-specific treatment to ameliorate the symptoms of the patient are the only options currently. […] Due to the homology in epidemiology, genomics, and pathogenesis of the SARS-CoV-2 and SARS-CoV, and the widely use of TCM in the treatment of SARS-CoV, the clinical evidence showing the beneficial effect of TCM in the treatment of patients with SARS coronaviral infections are discussed. 2020-04-03
Perspectives on therapeutic neutralizing antibodies against the Novel Coronavirus SARS-CoV-2. Herein, the host immune responses against SARS-CoV discussed in this review provide implications for developing NAbs and understanding clinical interventions against SARS-CoV-2. 2020-04-03
Knowledge, attitudes, and practices towards COVID-19 among Chinese residents during the rapid rise period of the COVID-19 outbreak: a quick online cross-sectional survey. The knowledge questionnaire consisted of 12 questions regarding the clinical characteristics and prevention of COVID-19. 2020-04-03
COVID-19: what has been learned and to be learned about the novel coronavirus disease. Similar to its homologous virus, SARS-CoV, which caused SARS in thousands of people in 2003, SARS-CoV-2 might also be transmitted from the bats and causes similar symptoms through a similar mechanism. 2020-04-03
The Fear of COVID-19 Scale: Development and Initial Validation. The present study developed the Fear of COVID-19 Scale (FCV-19S) to complement the clinical efforts in preventing the spread and treating of COVID-19 cases. 2020-04-02
Acetazolamide, Nifedipine and Phosphodiesterase Inhibitors: Rationale for Their Utilization as Adjunctive Countermeasures in the Treatment of Coronavirus Disease 2019 (COVID-19). The aim of this article is to outline a perspective on the pathophysiology of COVID-19 in the context of the currently available clinical data published in the literature. […] This article appreciates clinical data published on COVID-19 in the context of another respiratory illness - high altitude pulmonary edema (HAPE). 2020-04-02
COVID-19 in a Patient Presenting with Syncope and a Normal Chest X-ray. While fever and respiratory symptoms have been commonly used to identify COVID-19 suspects, we present an elderly female who arrived to the hospital after a syncopal episode. 2020-04-01
The ACE2 expression in human heart indicates new potential mechanism of heart injury among patients infected with SARS-CoV-2. The finding of this study explains the high rate of severe cases among COVID-19 patients with basic cardiovascular disease; and these results also perhaps provide important reference to clinical treatment of cardiac injury among severe patients infected by SARS-CoV-2. 2020-03-31
Novel Coronavirus Pneumonia (COVID-19) Progression Course in 17 Discharged Patients: Comparison of Clinical and Thin-Section CT Features During Recovery. To retrospectively analyze the evolution of clinical features and thin-section CT imaging of novel coronavirus pneumonia (COVID-19) in 17 discharged patients. […] Longitudinal changes of clinical parameters and CT pattern were documented in all patients during 4 weeks since admission. […] The progression course of CT pattern was later than the clinical parameters within the first two weeks since admission; however, there was a synchronized improvement in both clinical and radiologic features in the 4th week. 2020-03-31
Characteristics of peripheral lymphocyte subset alteration in COVID-19 pneumonia. We aimed to clarify the characteristics and clinical significance of peripheral lymphocyte subset alteration in COVID-19. […] The levels of peripheral lymphocyte subsets were measured by flow cytometry in 60 hospitalized COVID-19 patients before and after treatment, and their association with clinical characteristics and treatment efficacy was analyzed. […] After treatment, 37 patients (67%) reached clinical response, with an increase of CD8+ T cells and B cells. […] Peripheral lymphocyte subset alteration was associated with the clinical characteristics and treatment efficacy of COVID-19. 2020-03-31
The correlation between viral clearance and biochemical outcomes of 94 COVID-19 infected discharged patients. The clinical and laboratory findings were extracted from the electronic medical records of the patients. […] Information on clinical signs and symptoms, medical treatment, virus clearance, and laboratory parameters including interleukin 6 (IL-6) and C-reactive protein were collected. 2020-03-31
COVID-19 treatment by repurposing drugs until the vaccine is in sight. Clinical trials should also be undertaken to use statins, which are lipid-lowering drugs but have anti-inflammatory and immunomodulatory properties to prevent acute lung injury in COVID-19 infection. 2020-03-31
Covid-19 in Critically Ill Patients in the Seattle Region - Case Series. Clinical data were obtained through review of medical records. […] The mean (±SD) age of the patients was 64±18 years, 63% were men, and symptoms began 7±4 days before admission. […] The most common symptoms were cough and shortness of breath; 50% of patients had fever on admission, and 58% had diabetes mellitus. 2020-04-16
Fast reshaping of intensive care unit facilities in a large metropolitan hospital in Milan, Italy: facing the COVID-19 pandemic emergency Furthermore, besides clinical activities, continuously important research projects were carried out in order to find new strategies and more effective therapies to better face an unprecedented health emergency in Italy. 2020-04-01
Renin-angiotensin system inhibitors improve the clinical outcomes of COVID-19 patients with hypertension. The dysfunction of the renin-angiotensin system (RAS) has been observed in coronavirus infection disease (COVID-19) patients, but whether RAS inhibitors, such as angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin II type 1 receptor blockers (ARBs), are associated with clinical outcomes remains unknown. […] This evidence supports the benefit of using ACEIs or ARBs to potentially contribute to the improvement of clinical outcomes of COVID-19 patients with hypertension. 2020-04-02
Transcriptomic characteristics of bronchoalveolar lavage fluid and peripheral blood mononuclear cells in COVID-19 patients. The transcriptome dataset of COVID-19 patients would be a valuable resource for clinical guidance on anti-inflammatory medication and understanding the molecular mechansims of host response. 2020-04-02
COVID-19, ACE2, and the cardiovascular consequences. In lieu of the fact that many older patients with hypertension or other CVDs are routinely treated with RAAS blockers and statins, new clinical concerns have developed regarding whether these patients are at greater risk for SARS-CoV-2 infection, whether RAAS and statin therapy should be discontinued, and the potential consequences of RAAS blockade to COVID-19-related pathologies such as acute and chronic respiratory disease. 2020-04-16
Epidemiological Characteristics on the Clustering Nature of COVID-19 in Qingdao City, 2020: A Descriptive Analysis. The epidemiological characteristics and clinical manifestations were analyzed. 2020-04-16
Asymptomatic and Human-to-Human Transmission of SARS-CoV-2 in a 2-Family Cluster, Xuzhou, China. We report epidemiologic, laboratory, and clinical findings for 7 patients with 2019 novel coronavirus disease in a 2-family cluster. […] These findings might also serve as a practical reference for clinical diagnosis and medical treatment. 2020-04-01
How to reduce the likelihood of coronavirus-19 (CoV-19 or SARS-CoV-2) infection and lung inflammation mediated by IL-1. The severity of the disease depends on the efficiency of the immune system which, if it is weak, cannot stem the infection and its symptoms. 2020-04-01
[Exploration of omics mechanism and drug prediction of coronavirus-induced heart failure based on clinical bioinformatics]. Future basic and clinical research is warranted to validate present results and hypothesis. 目的: 探讨冠状病毒感染所致心力衰竭(心衰)的机制,并预测对其可能有疗效的药物。 2020-04-01
Dynamic change process of target genes by RT-PCR testing of SARS-Cov-2 during the course of a Coronavirus Disease 2019 patient. We report the dynamic change process of target genes by RT-PCR testing of SARS-Cov-2 during the course of a COVID-19 patient: from successive negative results to successive single positive nucleocapsid gene, to two positive target genes (orf1ab and nucleocapsid) by RT-PCR testing of SARS-Cov-2, and describe the diagnosis, clinical course, and management of the case. […] In this case, negative results of RT-PCR testing was not excluded to diagnose a suspected COVID-19 patient, clinical signs and symptoms, other laboratory findings, and chest CT images should be taken into account for the absence of enough positive evidence. 2020-04-16
Risk-adapted Treatment Strategy For COVID-19 Patients. We collected the medical records of 55 COVID-19 patients for analysis. […] At the end of the first two weeks after admission, clinical manifestations had completely despeared in 31(91.2%)patients in non-severe group, and 18(85.7%) patients in severe group (p=0.85). […] There were 45 cases were discharged from the hospital, and no patients died at the time of this clinical analysis. […] Risk-adapted treatment strategy was associated with significant clinical manifestations alleviation and clinical imaging recovery. 2020-04-01
Diagnosis of the Coronavirus disease (COVID-19): rRT-PCR or CT? For patients with a final confirmed diagnosis, clinical and laboratory data, in addition to CT imaging findings were evaluated. 2020-04-16
The psychological impact of the COVID-19 epidemic on college students in China. Results of correlation analysis indicated that economic effects, and effects on daily life, as well as delays in academic activities, were positively associated with anxiety symptoms (P < .001). 2020-04-10
Geroprotective and senoremediative strategies to reduce the comorbidity, infection rates, severity, and lethality in gerophilic and gerolavic infections. This article also highlights a need for rigorous clinical validation of deep aging clocks as surrogate markers of biological age. […] This article does not represent medical advice and the medications described are not yet licensed or recommended as immune system boosters, as they have not undergone clinical evaluation for this purpose. 2020-04-01
COVID-19 and chronological aging: senolytics and other anti-aging drugs for the treatment or prevention of corona virus infection? Thus, we propose that new clinical trials may be warranted, as several senolytic and anti-aging therapeutics are existing FDA-approved drugs, with excellent safety profiles, and would be readily available for drug repurposing efforts. 2020-04-01
Coronavirus Disease 19 Infection Does Not Result in Acute Kidney Injury: An Analysis of 116 Hospitalized Patients from Wuhan, China. Whether the patients with coronavirus disease 19 (COVID-19) infected by severe acute respiratory syndrome (SARS)-CoV-2 would commonly develop acute kidney injury (AKI) is an important issue worthy of clinical attention. […] This study aimed to explore the effects of SARS-CoV-2 infection on renal function through analyzing the clinical data of 116 hospitalized COVID-19-confirmed patients. […] The recorded information includes demographic data, medical history, contact history, potential comorbidities, symptoms, signs, laboratory test results, chest computer tomography scans, and treatment measures. 2020-04-01
Hypertension and its severity or mortality in Coronavirus Disease 2019 (COVID-19): a pooled analysis. As the coronavirus disease 2019 (COVID-19) outbreak, identification of clinical predictors of severe or fatal disease are necessary to enable risk stratification and optimize allocation of limited resources. 2020-04-01
Risks of Novel Coronavirus Disease (COVID-19) in Pregnancy; a Narrative Review. There has been no report of vertical transmission in pregnancy, and it has been found that clinical symptoms of COVID-19 in pregnant women are not different from those of non-pregnant women. 2020-04-04
Prevalence of Underlying Diseases in Hospitalized Patients with COVID-19: a Systematic Review and Meta-Analysis. All relevant articles that reported clinical characteristics and epidemiological information of hospitalized COVID-19 patients were included in the analysis. 2020-04-04
Experience of Diagnosing and Managing Patients in Oral Maxillofacial Surgery during the Prevention and Control Period of the New Coronavirus Pneumonia. As one of the busiest specialised hospitals in the world, the Department of Oral and Maxillofacial Surgery of Peking University School and Hospital of Stomatology summarised the experience with disease prevention and control and clinical recommendations on the examination, diagnosis and treatment processes, clinical management, healthcare personnel protection and disinfection amid the continued spread of the pandemic. 2020-04-02
Balancing Health Privacy, Health Information Exchange and Research in the Context of the COVID-19 Pandemic. However, our current regulations on the flows of information for clinical care and research are antiquated and often conflict at the state and federal level. 2020-04-01
Characteristics of Ocular Findings of Patients With Coronavirus Disease 2019 (COVID-19) in Hubei Province, China. During the period of treatment, the ocular signs and symptoms as well as results of blood tests and reverse transcriptase-polymerase chain reaction (RT-PCR) from nasopharyngeal and conjunctival swabs for SARS-CoV-2 were noted and analyzed. […] Ocular signs and symptoms as well as results of blood tests and RT-PCR for SARS-CoV-2. […] By univariate analysis, patients with ocular symptoms were more likely to have higher white blood cell and neutrophil counts and higher levels of procalcitonin, C-reactive protein, and lactate dehydrogenase than patients without ocular symptoms. 2020-04-04
Diagnostic performance of chest CT to differentiate COVID-19 pneumonia in non-high-epidemic area in Japan. Chest CT would play a supplemental role to differentiate COVID-19 pneumonia from other respiratory diseases presenting with similar symptoms in a clinical setting. 2020-04-01
Clinical and Transmission Characteristics of Covid-19 - A Retrospective Study of 25 Cases from a Single Thoracic Surgery Department. In this study, we analyzed clinical and transmission features of 25 cases of Covid-19 from a single thoracic department, including 13 patients and 12 health care staff. 2020-04-01
Response to “Comments on ‘Zhang et al.: Clinical trial analysis of 2019-nCoV therapy registered in China’”. With the purpose of letting the public know the overall situation of the clinical trials of new coronary pneumonia in China as soon as possible, we completed the data collection and brief analysis in a very short time. 2020-04-01
Diabetes is a risk factor for the progression and prognosis of COVID-19. Demographic data, medical history, symptoms and signs, laboratory findings, chest computed tomography (CT) as well the treatment measures were collected and analysed. 2020-04-08
Overview of guidance for endoscopy during the coronavirus disease 2019 (COVID-19) pandemic. Clinical departments that perform endoscopy are faced with daunting challenges during this pandemic. 2020-04-01
Network pharmacology-based analysis of the role of traditional Chinese herbal medicines in the treatment of COVID-19. However, further clinical studies with large sample sizes are required to verify their effectiveness. 2020-04-13
Risk factors associated with disease progression in a cohort of patients infected with the 2019 novel coronavirus. The clinical, radiologic, and laboratory characteristics were retrospectively analyzed, and the factors associated with the disease progression were screened by binary logistic regression analysis. […] Fever (11/64.7%) and cough (8/47.1%) were the most common symptoms, whereas dyspnea (2/11.8%) and fatigue (3/17.6%) were rare, and there was no patient with diarrhea symptoms. […] There were no significant differences between the 2 groups with respect to their clinical characteristics. 2020-04-13
The outbreak of COVID-19 coronavirus and its impact on global mental health. This outbreak is leading to additional health problems such as stress, anxiety, depressive symptoms, insomnia, denial, anger and fear globally. 2020-04-02
Novel coronavirus in a 15-day-old neonate with clinical signs of sepsis, a case report. The clinical course of the disease in children and infants is milder than in adults. […] It should be noted that, although typical symptoms may be present in children, non-specific symptoms could be noted in the neonate. […] His mother had symptoms of Novel coronavirus. […] Eventually, the baby was discharged in good general condition.Conclusion: When a newborn presents with non-specific symptoms of infection with an added history of COVID-19 in his/her parents, it indicates the need for PCR testing for Novel coronavirus. 2020-04-16
The Role of Emergency Radiology in COVID-19: From Preparedness to Diagnosis. We review the symptoms, epidemiology, and testing for this disease. 2020-04-02
Protected Code Stroke: Hyperacute Stroke Management During the Coronavirus Disease 2019 (COVID-19) Pandemic. Background and Purpose- Hyperacute assessment and management of patients with stroke, termed code stroke, is a time-sensitive and high-stakes clinical scenario. […] In the context of the current Coronavirus Disease 2019 (COVID-19) pandemic caused by the SARS-CoV-2 virus, the ability to deliver timely and efficacious care must be balanced with the risk of infectious exposure to the clinical team. […] Furthermore, rapid and effective stroke care remains paramount to achieve maximal functional recovery for those needing admission and to triage care appropriately for those who may be presenting with neurological symptoms but have an alternative diagnosis. […] Methods- Available resources, COVID-19-specific infection prevention and control recommendations, and expert consensus were used to identify clinical screening criteria for patients and provide the required nuanced considerations for the healthcare team, thereby modifying the conventional code stroke processes to achieve a protected designation. […] Features specific to prenotification and clinical status of the patient were used to define precode screening. […] These include primary infectious symptoms, clinical, and examination features. 2020-04-02
[An epidemiologic thinking on the diagnosis criteria of COVID-19]. We suggested that COVID-19 should be diagnosed as 3 types: suspected case, clinical diagnosed case, and definite diagnosed case. 2020-04-02
[Epidemiological characteristics of COVID-19 in Gansu province]. Objective: To understand the epidemiological characteristics of COVID-19 cases in different epidemic stages in Gansu province. Methods: Epidemiological investigation was conducted to collect the information of confirmed COVID-19 cases, including demographic, epidemiological and clinical information. Results: As of 25 February 2020, a total of 91 confirmed COVID-19 cases had been reported in Gansu. […] The initial symptoms included fever (54.95%, 50/91), cough (52.75%, 48/91), or fatigue (28.57%, 26/91), the proportion of each symptom showed a decreasing trend along with the three epidemic stages, but only the differences in proportions of fever (trend χ2=2.20, P<0.05) and fatigue (trend χ2=3.18, P<0.05) among the three epidemic stages were statistically significant. […] The cases with critical severe symptoms accounted for 42.85% (6/14), 23.73% (14/59) and 16.67% (3/18), respectively, in three epidemic stages, showed a decreasing trend (H=6.45, P<0.05). 2020-04-02
[Progress and challenge of vaccine development against 2019 novel coronavirus (2019-nCoV)]. As of March 2020, two 2019-nCoV vaccines have entered phase I clinical trials. 2020-04-02
[Analysis of CT features of 15 children with 2019 novel coronavirus infection]. Objective: To explore imaging characteristics of children with 2019 novel coronavirus (2019-nCoV) infection. Methods: A retrospective analysis was performed on clinical data and chest CT images of 15 children diagnosed with 2019-nCoV infection. […] The clinical symptoms of children with 2019-nCoV infection are nonspecific. 2020-04-03
Spinal anaesthesia for patients with coronavirus disease 2019 and possible transmission rates in anaesthetists: retrospective, single-centre, observational cohort study. Here, we report the clinical characteristics and outcomes for both patients with COVID-19 and the anaesthetists who provided their spinal anaesthesia. […] Clinical characteristics and perioperative outcomes were recorded. […] For anaesthesiologists exposed to patients with COVID-19 by providing spinal anaesthesia, the level of personal protective equipment (PPE) used, clinical outcomes (pulmonary CT scans), and confirmed COVID-19 transmission rates (polymerase chain reaction [PCR]) were reviewed. 2020-04-02
COVID-19, SARS and MERS: are they closely related? Although related to the Severe Acute Respiratory Syndrome (SARS) and the Middle East Respiratory Syndrome (MERS), COVID-19 shows some peculiar pathogenetic, epidemiological and clinical features which have not been completely understood to date. […] We provide a review of the differences in terms of pathogenesis, epidemiology and clinical features between COVID-19, SARS and MERS. […] COVID-19 seems not to be very different from SARS regarding its clinical features. […] It cannot be excluded that because of the COVID-19 less severe clinical picture it can spread in the community more easily than MERS and SARS. 2020-04-02
Recent progress in understanding 2019 novel coronavirus (SARS-CoV-2) associated with human respiratory disease: detection, mechanisms and treatment. Here we scrutinise a series of available studies by global scientists on the clinical manifestations, detection methods and treatment options for the disease caused by SARS-CoV-2, named coronavirus disease 2019 (COVID-19), and also propose potential strategies for preventing the infection. 2020-04-15
The cytokine release syndrome (CRS) of severe COVID-19 and Interleukin-6 receptor (IL-6R) antagonist Tocilizumab may be the key to reduce the mortality. With the collation and publication of more and more clinical data, a large number of data suggest that there are mild or severe cytokine storms in severe patients, which is also an important cause of death. 2020-04-09
EMA advice on the use of NSAIDs for Covid-19. Every month, DTB scans sources of information on treatments, disease management and other healthcare topics for key items to bring to our readers’ attention and help them keep up to date. 2020-04-02
Progress and Prospects on Vaccine Development against SARS-CoV-2. While most of the vaccines are under design and preparation, there are some that have entered efficacy evaluation in animals and initial clinical trials. 2020-04-02
Novel Coronavirus Infection (COVID-19) in Humans: A Scoping Review and Meta-Analysis. We performed a scoping review of currently available clinical, epidemiological, laboratory, and chest imaging data related to the SARS-CoV-2 infection. […] Qualitative synthesis and meta-analysis were conducted using the clinical and laboratory data, and random-effects models were applied to estimate pooled results. […] The most common disease-related symptoms were fever (82%, 95% confidence interval (CI) 56%-99%; n = 4410), cough (61%, 95% CI 39%-81%; n = 3985), muscle aches and/or fatigue (36%, 95% CI 18%-55%; n = 3778), dyspnea (26%, 95% CI 12%-41%; n = 3700), headache in 12% (95% CI 4%-23%, n = 3598 patients), sore throat in 10% (95% CI 5%-17%, n = 1387) and gastrointestinal symptoms in 9% (95% CI 3%-17%, n = 1744). […] The majority of reported clinical symptoms and laboratory findings related to SARS-CoV-2 infection are non-specific. […] Clinical suspicion, accompanied by a relevant epidemiological history, should be followed by early imaging and virological assay. 2020-04-02
Virological assessment of hospitalized patients with COVID-2019. By causing an early onset of severe symptoms, this same receptor tropism is thought to have determined pathogenicity, but also aided the control, of severe acute respiratory syndrome (SARS) in 20035. […] However, there are reports of COVID-19 cases with mild upper respiratory tract symptoms, suggesting the potential for pre- or oligosymptomatic transmission6-8. […] Pharyngeal virus shedding was very high during the first week of symptoms (peak at 7.11 × 108 RNA copies per throat swab, day 4). […] Shedding of viral RNA from sputum outlasted the end of symptoms. 2020-04-02
The surgeons and the COVID-19 pandemic. In this regard, the high number of scientific publications, encompassing in vitro, case studies, observational and randomized clinical studies, and even systematic reviews add up to the uncertainty. 2020-04-06
A new threat from an old enemy: Re‑emergence of coronavirus (Review). In the present review, we address current knowledge on coronaviruses from a short history to epidemiology, pathogenesis, clinical manifestation of the disease, as well as treatment and prevention strategies. 2020-04-02
Why the immune system fails to mount an adaptive immune response to a Covid -19 infection. The range of clinical presentations varies from asymptomatic and mild clinical symptoms to acute respiratory-distress syndrome (ARDS) and death. […] However, the results of preliminary studies and clinical trials are improving our understanding of the pathogenesis and treatment of Covid-19. 2020-04-02
Is Pakistan prepared for the COVID-19 epidemic? A questionnaire-based survey. Knowledge about origin, symptoms, and spread of viral infection was assessed. 2020-04-10
Quarantined. Beginning of March, I worked in the emergency department and treated a patient with viral symptoms without a travel history who was admitted to the hospital. 2020-04-02
Isolation and rapid sharing of the 2019 novel coronavirus (SARS-CoV-2) from the first patient diagnosed with COVID-19 in Australia. Clinical course and laboratory features of the first reported case of COVID-19 (the illness caused by SARS-CoV-2) in Australia; isolation, whole genome sequencing, imaging, and rapid sharing of virus from the patient. 2020-04-05
Guidelines for Laboratory Diagnosis of Coronavirus Disease 2019 (COVID-19) in Korea. Korean Society for Laboratory Medicine and the Korea Centers for Disease Prevention and Control propose guidelines for diagnosing COVID-19 in clinical laboratories in Korea. 2020-04-02
A case of imported COVID-19 diagnosed by PCR-positive lower respiratory specimen but with PCR-negative throat swabs. A 35-year-old woman presented with fever and mild diarrhoea without any respiratory symptoms 9 days after travelling to Japan from Wuhan, China. […] A lower respiratory tract specimen should be obtained for better diagnosis of corona virus disease 2019, even in the absence of respiratory symptoms for patients with significant travel or exposure history. 2020-04-16
Case Report: Walking Pneumonia in Novel Coronavirus Disease (COVID-19): Mild Symptoms with Marked Abnormalities on Chest Imaging. She presented to the hospital because of her concern, but she was without fever or any respiratory symptoms. 2020-04-02
[From SARS to COVID-19: pathogens, receptor, pathogenesis and principles of the treatment]. Among the biological nature of the pathogens, viral receptor distribution on the human cells, and the pathological findings in the targeted organs and clinical features of the patients with the diseases, found similarities and differences between the two diseases. 2020-04-02
Clinical Research Slows as COVID-19 Surges. As the COVID-19 pandemic worsens, the clinical cancer community is grappling with how to continue providing access to experimental but potentially lifesaving therapies while keeping immunocompromised patients safe. […] To that end, cancer centers are making changes to their clinical trial programs, while pharmaceutical companies are deciding how-or whether-trials should continue. 2020-04-02
INCIDENTAL FINDINGS SUGGESTIVE OF COVID-19 IN ASYMPTOMATIC PATIENTS UNDERGOING NUCLEAR MEDICINE PROCEDURES IN A HIGH PREVALENCE REGION. Infection with the novel coronavirus SARS-CoV-2 may remain asymptomatic, leading to under-recognition of the related disease, COVID-19, and to incidental findings in nuclear imaging procedures performed for standard clinical indications. […] Presence, radiological features and metabolic activity of interstitial pneumonia were identified, correlated with subsequent short-term clinical course and described in a case series. Results: Six of 65 patients (9%) that underwent PET/CT for various malignancies showed unexpected signs of interstitial pneumonia on CT and elevated regional FDG-avidity. 2020-04-02
Does COVID19 infect the brain? If so, smokers might be at a higher risk. Infected individuals report a range of symptoms from headaches to shortness of breath to taste and smell loss. 2020-04-02
Novel Coronavirus 2019 (2019-nCoV) Infection: Part I - Preparedness and Management in the Pediatric Intensive Care Unit in Resource-limited Settings. Diagnosis involves a combination of clinical and epidemiological features with laboratory confirmation. 2020-04-16
Novel Coronavirus 2019 (2019-nCoV) Infection: Part II - Respiratory Support in the Pediatric Intensive Care Unit in Resource-limited Settings. The 2019-novel coronavirus predominantly affects the respiratory system with manifestations ranging from upper respiratory symptoms to full blown acute respiratory distress syndrome (ARDS). 2020-04-16
Perinatal-Neonatal Management of COVID-19 Infection - Guidelines of the Federation of Obstetric and Gynecological Societies of India (FOGSI), National Neonatology Forum of India (NNF), and Indian Academy of Pediatrics (IAP). Perinatal period poses unique challenges and care of the mother-baby dyads requires special resources for prevention of transmission, diagnosis of infection and providing clinical care during labor, resuscitation and postnatal period. […] Existing guidelines, systematic reviews, clinical trials, narrative reviews and other descriptive reports were reviewed. […] To provide recommendations for prevention of transmission, diagnosis of infection and providing clinical care during labor, resuscitation and postnatal period. […] A set of twenty recommendations are provided under the following broad headings: 1) pregnant women with travel history, clinical suspicion or confirmed COVID-19 infection; 2) neonatal care; 3) prevention and infection control; 4) diagnosis; 5) general questions. 2020-04-02
[Remdesivir, the antiviral hope against SARS-CoV-2]. However, studies and clinical trials in humans are required to know the result of their application in them. 2020-04-04
Clinical Features and Short-term Outcomes of 102 Patients with Corona Virus Disease 2019 in Wuhan, China. In this study, we investigate clinical and laboratory features and short-term outcomes of patients with Corona Virus Disease 2019(COVID-19). […] Epidemiological, clinical, radiological characteristics, underlying diseases, laboratory tests treatment, complications and outcomes data were collected. 2020-04-02
Potential covalent drugs targeting the main protease of the SARS-CoV-2 coronavirus. Clinical drugs targeting SARS-CoV-2 are urgently needed to decrease the high fatality rate of confirmed COVID-19 patients. […] Since the preclinical or clinical information of these identified drugs is already available, they might be ready for being clinically tested in the treatment of COVID-19. 2020-04-02
Radiologic chest CT findings from COVID-19 in Orleans Parish, Louisiana. Orleans Parish in Louisiana is in the midst of an exponentially increasing number of patient admissions with COVID-19 and respiratory symptoms. […] Patients have been described having CT findings most consistent with an early-stage (<7 days from symptoms onset) or an advanced stage (8-14 days from symptoms onset). 2020-04-13
Our Italian experience using lung ultrasound for identification, grading and serial follow-up of severity of lung involvement for management of patients with COVID-19. Use of LU has helped us in clinical decision making and reduced the use of both chest x-rays and computed tomography (CT). 2020-04-15
Clinical characteristics of non-ICU hospitalized patients with coronavirus disease 2019 and liver injury: A retrospective study. The clinical characteristics of patients with liver injury and without liver injury were compared. […] There were no significant differences in age, previous medical history and symptoms between the two groups. 2020-04-13
COVID-19 in a Designated Infectious Diseases Hospital Outside Hubei Province, China. The clinical characteristics of novel coronavirus disease (COVID-2019) patients outside the epicenter of Hubei province are less understood. […] We analyzed the epidemiological and clinical features of all COVID-2019 cases in the only referral hospital in Shenzhen city, China from January 11, 2020 to February 6, 2020 and followed until March 6, 2020. 2020-04-02
Liver impairment in COVID-19 patients: a retrospective analysis of 115 cases from a single center in Wuhan city, China. The aim of our study was to investigate the changes of liver function and its clinical significance in COVID-19 patients. […] However, the clinical significance of the elevation is unremarkable. […] Although abnormalities of liver function indexes are common in COVID-19 patients, the impairment of liver function is not a prominent feature of COVID-19, and also may not have serious clinical consequences. 2020-04-02
Severe Acute Respiratory Syndrome Coronavirus 2 Shedding by Travelers, Vietnam, 2020. One asymptomatic patient demonstrated virus shedding, indicating potential virus transmission in the absence of clinical signs and symptoms. 2020-04-02
Use of Rapid Online Surveys to Assess People’s Perceptions During Infectious Disease Outbreaks: A Cross-sectional Survey on COVID-19. Participants generally had good knowledge of the main mode of disease transmission and common symptoms of COVID-19. 2020-04-09
Emergence of a Novel Coronavirus (COVID-19): Protocol for Extending Surveillance Used by the Royal College of General Practitioners Research and Surveillance Centre and Public Health England. This extended surveillance comprises of five components: (1) Recording in medical records of anyone suspected to have or who has been exposed to COVID-19. […] Computerized medical records suppliers have within a week of request created new codes to support this. […] General practice clinical system providers have introduced an emergency new set of clinical codes to support COVID-19 surveillance. 2020-04-09
Asymptomatic and Presymptomatic SARS-CoV-2 Infections in Residents of a Long-Term Care Skilled Nursing Facility - King County, Washington, March 2020. Residents were categorized as asymptomatic or symptomatic at the time of testing, based on the absence or presence of fever, cough, shortness of breath, or other symptoms on the day of testing or during the preceding 14 days. […] Among 23 (30%) residents with positive test results, 10 (43%) had symptoms on the date of testing, and 13 (57%) were asymptomatic. […] Seven days after testing, 10 of these 13 previously asymptomatic residents had developed symptoms and were recategorized as presymptomatic at the time of testing. […] The reverse transcription-polymerase chain reaction (RT-PCR) testing cycle threshold (Ct) values indicated large quantities of viral RNA in asymptomatic, presymptomatic, and symptomatic residents, suggesting the potential for transmission regardless of symptoms. 2020-04-06
Isolated sudden onset anosmia in COVID-19 infection. A novel syndrome? A patient presenting with ISOA who went on to test positive for infection with COVID-19 and did not develop any further symptoms as well as a case series of similar patients although limited by the lack of reliable testing at the moment. 2020-04-02
Electronic Personal Protective Equipment: A Strategy to Protect Emergency Department Providers in the Age of COVID-19. Emergent policy changes related to telemedicine and the Emergency Medical Treatment and Labor Act (EMTALA) during the novel coronavirus pandemic (COVID-19) have created opportunities for technology-based clinical evaluation, which serves to conserve personal protective equipment (PPE) and protect emergency providers. 2020-04-02
Coronavirus disease 2019 (COVID-19): a clinical update. The efficacy of some promising antivirals, convalescent plasma transfusion, and tocilizumab needs to be investigated by ongoing clinical trials. 2020-04-02
Collecting and evaluating convalescent plasma for COVID-19 treatment: why and how. Careful clinical evaluation should allow to quickly establish whether such passive immunotherapy, administered at early phases of the disease in patients at high risk of deleterious evolution may reduce the frequency of patient deterioration, and thereby COVID-19 mortality. 2020-04-02
How young patients with cancer perceive the Covid-19 (coronavirus) epidemic in Milan, Italy: is there room for other fears? We believe that we need to adequately inform our patients, focusing on hygienic measures and personal protection and prompt reporting of any suspicious symptoms. 2020-04-09
Estimates of the severity of coronavirus disease 2019: a model-based analysis. These individual-case data were used to estimate the time between onset of symptoms and outcome (death or discharge from hospital). […] Using data on 24 deaths that occurred in mainland China and 165 recoveries outside of China, we estimated the mean duration from onset of symptoms to death to be 17·8 days (95% credible interval [CrI] 16·9-19·2) and to hospital discharge to be 24·7 days (22·9-28·1). 2020-04-16
Coronavirus disease 2019 in elderly patients: Characteristics and prognostic factors based on 4-week follow-up. Data of demographics, clinical features, comorbidities, laboratory tests and complications were collected and compared for different outcomes. […] Common symptoms included fever (92.0%), cough (53.0%), dyspnea (40.8%) and fatigue (39.9%). […] Symptoms of dyspnea (HR 2.35, P = 0.001), comorbidities including cardiovascular disease (HR 1.86, P = 0.031) and chronic obstructive pulmonary disease (HR 2.24, P = 0.023), and acute respiratory distress syndrome (HR 29.33, P < 0.001) were strong predictors of death. 2020-04-14
COVID-19 in Hemodialysis Patients: A Report of 5 Cases. In this Case Report, we describe the clinical and epidemiological features of COVID-19 in 201 maintenance hemodialysis patients in Zhongnan Hospital of Wuhan university, including 5 maintenance hemodialysis patients who contracted COVID-19 disease. […] Diarrhea (80%), fever (60%), and fatigue (60%) were the most common symptoms. 2020-04-04
Creating a Palliative Care Inpatient Response Plan for COVID19 - The UW Medicine Experience. The strategy focuses on key content areas including identifying and addressing goals of care, addressing moderate and severe symptoms, and supporting family members. 2020-04-02
Telemedicine in the Time of Coronavirus. Within weeks, COVID-19 has transformed our practice of palliative care and clinical medicine as we know it. 2020-04-02
Prevalence and predictors of PTSS during COVID-19 outbreak in China hardest-hit areas: Gender differences matter. Our objective was to investigate the prevalence and predictors of posttraumatic stress symptoms (PTSS) in China hardest-hit areas during COVID-19 outbreak, especially exploring the gender difference existing in PTSS. 2020-04-10
SARS-CoV-2 is not detectable in the vaginal fluid of women with severe COVID-19 infection. Clinical records, laboratory results, and computer tomography(CT)-scan examination were retrospectively reviewed. […] The clinical characteristics of these ten women were similar to those reported severe COVID-19 patients. 2020-04-02
[Suggestions for thoracic surgery clinical practice in non-epidemic area of 2019 coronavirus disease]. Secondly, the clinical features, CT imaging, short-term and long-term pulmonary function damage of the 2019 coronavirus disease (COVID-19) was analyzed. […] Finally, some suggestions for thoracic surgery clinical practice in non-epidemic area during and after the epidemic of COVID-19 were provided, to help all the thoracic surgery patients receive active and effective treatment. 2020-04-03
[Comparison of clinical and pathological features between severe acute respiratory syndrome and coronavirus disease 2019]. Severe acute respiratory syndrome (SARS) and coronavirus disease 2019 (COVID-19) shared similar pathogenetic, clinical and pathological features. […] Fever and cough were the most common symptoms of both diseases, while myalgia and diarrhea were less common in patients with COVID-19. 2020-04-03
Diagnostic Value and Key Features of Computed Tomography in Coronavirus Disease 2019. To date, computed tomography (CT) findings have been recommended as major evidence for the clinical diagnosis of COVID-19 in Hubei, China. […] Since most patients with COVID-19 infection share typical imaging features, radiological examinations have an irreplaceable role in screening, diagnosis and monitoring treatment effects in clinical practice. 2020-04-03
Case Report on Early Diagnosis of COVID-19. Based on the analysis of the cases of 4 patients, this article finds that early diagnosis requires a combination of epidemiology, clinical manifestations, imaging, and etiology, with particular emphasis on epidemiology history and chest CT manifestations. 2020-04-03
Gastrointestinal symptoms of 95 cases with SARS-CoV-2 infection. To study the GI symptoms in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infected patients. […] We analysed epidemiological, demographic, clinical and laboratory data of 95 cases with SARS-CoV-2 caused coronavirus disease 2019. […] Among the 95 patients, 58 cases exhibited GI symptoms of which 11 (11.6%) occurred on admission and 47 (49.5%) developed during hospitalisation. […] Diarrhoea (24.2%), anorexia (17.9%) and nausea (17.9%) were the main symptoms with five (5.3%), five (5.3%) and three (3.2%) cases occurred on the illness onset, respectively. […] Faecal samples of 65 hospitalised patients were tested for the presence of SARS-CoV-2, including 42 with and 23 without GI symptoms, of which 22 (52.4%) and 9 (39.1%) were positive, respectively. […] Six patients with GI symptoms were subjected to endoscopy, revealing oesophageal bleeding with erosions and ulcers in one severe patient. 2020-04-03
A consensus statement on the use of angiotensin receptor blockers and angiotensin converting enzyme inhibitors in relation to COVID-19 (corona virus disease 2019). We recommend that patients on such medications should continue on them unless there is a clinical indication to stop their use. 2020-04-09
Clinical Course and Outcomes of Patients with Severe Acute Respiratory Syndrome Coronavirus 2 Infection: a Preliminary Report of the First 28 Patients from the Korean Cohort Study on COVID-19. In this retrospective multicenter study, we investigated the clinical course and outcomes of novel coronavirus disease 2019 (COVID-19) from early cases in Republic of Korea. […] Clinical data were collected and analyzed for changes in clinical severity including laboratory, radiological, and virologic dynamics during the progression of illness. […] The most common symptoms were cough (28.6%) and sore throat (28.6%), followed by fever (25.0%). […] Two patients had no symptoms. […] The prodromal symptoms of COVID-19 were mild and most patients did not have limitations of daily activity. 2020-04-06
Primary care management of the coronavirus (COVID-19). The most common symptoms are fever, cough and shortness of breath. 2020-04-08
Clinical Features of 85 Fatal Cases of COVID-19 from Wuhan: A Retrospective Observational Study. To report the clinical features of 85 fatal cases with COVID-19 in two hospitals in Wuhan. […] Medical records of 85 fatal cases of COVID-19 between January 9 and February 15, 2020 were collected. […] Information recorded included medical history, exposure history, comorbidities, symptoms, laboratory findings, CT scans and clinical management. […] Common symptoms were fever (78 [91.8%]), shortness of breath (50 [58.8%]), fatigue (50 [58.8%]), dyspnea (60 [70.6%]). 2020-04-03
Laboratory diagnostics within a modular hospital at the time of Coronavirus disease 2019 (COVID-19) in Wuhan. As patients need to be treated and tested, it is important to develop a clinical laboratory in the modular hospital and ensure biosafety. […] The construction of a clinical laboratory in the modular hospital is faced with problems such as time pressure, limited site selection, high level of biosafety, lack of experience and so forth. […] This paper mainly discusses how to construct the clinical laboratory in the modular hospital quickly and safely and put it into use to provide testing service for patients under various limited conditions. 2020-04-03
Imaging and clinical features of patients with 2019 novel coronavirus SARS-CoV-2: A systematic review and meta-analysis. We aim to explore reliable evidence for the diagnosis and treatment of the COVID-19 by analyzing all the published studies by Chinese scholars on the clinical and imaging features in novel coronavirus pneumonia caused by SARS-CoV-2. […] A random-effects model was designed, and the imaging and clinical data from all studies were collected for meta-analysis. […] The results of meta-analysis showed that the most common clinical manifestations were fever (87.3%; 0.838-0.909), cough (58.1%; 0.502-0.660), dyspnea (38.3%; 0.246-0.520), muscle soreness or fatigue (35.5%; 0.253-0.456), and chest distress (31.2%; -0.024 to 0.648). […] COVID-19 is a new clinical infectious disease that mainly causes bilateral pneumonia and lung function deteriorates rapidly. 2020-04-10
Breastfeeding and Coronavirus Disease-2019. Ad interim indications of the Italian Society of Neonatology endorsed by the Union of European Neonatal & Perinatal Societies. We recognize that this guidance might be subject to change in the future when further knowledge will be acquired about the COVID-19 pandemic, the perinatal transmission of SARS-CoV-2 and clinical characteristics of cases of neonatal COVID-19. 2020-04-03
Chest CT Features of COVID-19 in Rome, Italy. Methods In this prospective study from March 4, 2020, until March 19, 2020, consecutive patients with suspected COVID-19 infection and respiratory symptoms were enrolled. 2020-04-03
Extracorporeal Membrane Oxygenation for Coronavirus Disease 2019 in Shanghai, China. In conclusion, ensuring effective, timely, and safe ECMO support in COVID-19 is key to improving clinical outcomes. 2020-04-06
Gastrointestinal and Liver Manifestations in Patients with COVID-19. Besides typical respiratory symptoms and signs of COVID-19, digestive symptoms and liver injury have been frequently reported during the course of the disease. […] Digestive symptoms, including anorexia, nausea, vomiting and diarrhea, are not uncommon in patients with COVID-19, and in some cases digestive symptoms may occur in the absence of any respiratory symptoms. 2020-04-03
Potential therapeutic agents against COVID-19: What we know so far. More clinical trials are being conducted for further confirmation of the efficacy and safety of these agents in treating COVID-19. 2020-04-03
Characteristics and Early Prognosis of COVID-19 Infection in Fracture Patients. Studies of the novel coronavirus-induced disease COVID-19 in Wuhan, China, have elucidated the epidemiological and clinical characteristics of this disease in the general population. […] The present investigation summarizes the clinical characteristics and early prognosis of COVID-19 infection in a cohort of patients with fractures. […] Analyses of early prognosis were based on clinical outcomes and trends in laboratory results during treatment. […] The clinical outcomes for the surviving patients are not yet determined. […] The clinical characteristics and early prognosis of COVID-19 in patients with fracture tended to be more severe than those reported for adult patients with COVID-19 without fracture. […] This finding may be related to the duration between the development of symptoms and presentation. 2020-04-03
The effectiveness of the quarantine of Wuhan city against the Corona Virus Disease 2019 (COVID-19): well-mixed SEIR model analysis. A well-mixed “susceptible exposed infectious recovered” (SEIR) compartmental model was employed to describe the dynamics of the COVID-19 epidemic based on epidemiological characteristics of individuals, clinical progression of COVID-19, and quarantine intervention measures of the authority. 2020-04-03
The Presence of SARS-CoV-2 RNA in Feces of COVID-19 Patients. Electronical medical records, including demographics, clinical characteristics, laboratory and radiological findings, of enrolled patients were extracted and analyzed. […] Viral shedding at multiple time points in specimens was recorded, and analyzed its correlation with clinical manifestations and the severity of illness. […] A total of 42 laboratory-confirmed patients were enrolled, 8 (19.05%) of whom had gastrointestinal symptoms. […] 28 (66.67%) patients tested positive for SARS-CoV-2 RNA in stool specimens, which was not associated with the presence of gastrointestinal symptoms and the severity of illness. […] The demographics, clinical characteristics, laboratory and radiologic findings did no differ between patients tested positive and negative for SARS-CoV-2 RNA in feces. 2020-04-03
A Practical Approach to the Management of Cancer Patients During the Novel Coronavirus Disease 2019 (COVID-19) Pandemic: An International Collaborative Group. This include changes to resource allocation, clinical care, and the consent process during a pandemic. 2020-04-05
SARS Cov2 infection in a renal transplanted patients. A case report. The clinical manifestation of COVID-19 can vary from an asymptomatic course to ARDS requiring invasive mechanical ventilation and extracorporeal membrane oxygenation. 2020-04-03
Successful Treatment of Severe COVID-19 Pneumonia in a Liver Transplant Recipient. Clinical data on COVID-19 infection in transplant population is very limited. […] Herein we presented the clinical course and outcome of a 50-year-old male post liver transplantation who contracted COVID-19, with subsequent infection of his wife. 2020-04-03
A familial cluster, including a kidney transplant recipient, of Coronavirus Disease 2019 (COVID-19) in Wuhan, China. The initial clinical symptoms of COVID-19 in these three patients were the same, but their progression was different. […] Based on the severity of clinical symptoms, chest computer tomography findings and SARS-Cov-2 RNA test results, we admitted the husband to the respiratory intensive care unit (RICU) and used a treatment consisting of immunosuppressant reduction/cessation and low dose methylprednisolone-based therapy, and his wife to the respiratory isolation ward. 2020-04-03
Why are pregnant women susceptible to COVID-19? An immunological viewpoint. Clinical manifestation of COVID-19 can be characterized by mild upper respiratory tract infection, lower respiratory tract infection involving non-life threatening pneumonia, and life-threatening pneumonia with acute respiratory distress syndrome. 2020-04-16
People with Suspected COVID-19 Symptoms Were More Likely Depressed and Had Lower Health-Related Quality of Life: The Potential Benefit of Health Literacy. The coronavirus disease 2019 (COVID-19) epidemic affects people’s health and health-related quality of life (HRQoL), especially in those who have suspected COVID-19 symptoms (S-COVID-19-S). […] The interviews were conducted using printed questionnaires including participants’ characteristics, clinical parameters, health behaviors, HL, depression, and HRQoL. 2020-04-06
SARS-CoV-2 and Coronavirus Disease 2019: What We Know So Far. Based on clinical criteria and available serological and molecular information, the new disease was called coronavirus disease of 2019 (COVID-19), and the novel coronavirus was called SARS Coronavirus-2 (SARS-CoV-2), emphasizing its close relationship to the 2002 SARS virus (SARS-CoV). 2020-04-06
Primary stratification and identification of suspected Corona virus disease 2019 (COVID-19) from clinical perspective by a simple scoring proposal. In the guideline, except for “confirmed cases”, “suspected cases”, “close contact” and “suspicious exposure” were defined by clinical perspective based on epidemiological risk, clinical symptoms and auxiliary examination. 2020-04-10
Updating the diagnostic criteria of COVID-19 “suspected case” and “confirmed case” is necessary. However, the coronavirus disease 2019 (COVID-19) is a new disease, our awareness and knowledge are gradually increasing based on the ongoing research findings and clinical practice experience; hence, the strategies of diagnosis and treatment are also continually updated. 2020-04-10
The Laboratory Diagnosis of COVID-19 Infection: Current Issues and Challenges. The COVID-19 outbreak has had a major impact on clinical microbiology laboratories in the past several months. 2020-04-04
Difference of coagulation features between severe pneumonia induced by SARS-CoV2 and non-SARS-CoV2. Coagulation results and clinical features of consecutive patients with severe pneumonia induced by SARS-CoV2 (COVID group) and non-SARS-CoV2 (non-COVID group) in Tongji hospital were retrospectively analyzed and compared. 2020-04-04
Respiratory failure alone does not suggest central nervous system invasion by SARS-CoV-2. The published clinical features of COVID-19 do not suggest that involvement of the CNS is common. 2020-04-04
Response to Commentary on “The neuroinvasive potential of SARS-CoV-2 may play a role in the respiratory failure of COVID-19 patients”. In a recent review, we have suggested a neuroinvasive potential of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and its possible role in the causation of acute respiratory failure of coronavirus disease 2019 (COVID-19) patients (J Med Viol doi: 10.1002/jmv.25728), based upon the clinical and experimental data available on the past SARS-CoV-1 and the recent SARS-CoV-2 pandemic. 2020-04-10
Pulmonary High-Resolution Computed Tomography (HRCT) Findings of Patients with Early-Stage Coronavirus Disease 2019 (COVID-19) in Hangzhou, China. All patients underwent thoracic high-resolution computed tomography (HRCT) within 2 days after the onset of symptoms, and their images were viewed by 2 radiologists who were blind to their clinical records. […] Thus, suspected cases need to be closely monitored, and epidemiological history and clinical laboratory examination should also be considered during diagnosis. 2020-04-09
Favipiravir: pharmacokinetics and concerns about clinical trials for 2019-nCoV infection. In addition to the recommended antiviral drugs such as interferon-ɑ, lopinavir/ritonavir, ribavirin, and chloroquine phosphate, some clinical trials focusing on virus RNA dependent RNA polymerase (RdRp) inhibitors have been registered and initiated. […] Favipiravir, a purine nucleic acid analog and potent RdRp inhibitor approved for use in influenza, is also considered in several clinical trials. […] We hope this will be helpful for the design of clinical trials for favipiravir in COVID-2019, as data regarding in vitro virus inhibition and efficacy in preclinical animal studies are still not available. 2020-04-04
Medical Masks vs N95 Respirators for Preventing COVID-19 in Health Care Workers A Systematic Review and Meta-Analysis of Randomized Trials. Compared to N95 respirators; the use of medical masks did not increase laboratory confirmed viral (including coronaviruses) respiratory infection (OR 1.06; 95% CI 0.90-1.25; I2 =0%; low certainty in the evidence) or clinical respiratory illness (OR 1.49; 95%CI 0.98-2.28; I2 =78%; very low certainty in the evidence). 2020-04-04
Insight into 2019 novel coronavirus - an updated intrim review and lessons from SARS-CoV and MERS-CoV. Based on recently published literatures, official documents and selected up-to-date preprint studies, we reviewed the virology and origin, epidemiology, clinical manifestations, pathology and treatment of 2019-nCoV infection, in comparison with severe acute respiratory syndrome coronavirus (SARS-CoV) and middle east respiratory syndrome coronavirus (MERS-CoV) infection. […] Clinical presentation and pathology of COVID-19 greatly resembled SARS and MERS, with less upper respiratory and gastrointestinal symptoms, and more exudative lesions in post-mortems. 2020-04-07
Chloroquine and hydroxychloroquine in the treatment of COVID-19 with or without diabetes: A systematic search and a narrative review with a special reference to India and other developing countries. Considering minimal risk upon use, a long experience of use in other diseases, cost-effectiveness and easy availability across India, we propose that both these drugs are worthy of fast track clinical trial for treatment, and may be carefully considered for clinical use as experimental drugs. 2020-04-10
Cardiovascular disease and COVID-19. Respiratory illness is the dominant clinical manifestation of COVID-19; CV involvement occurs much less commonly. […] Given the enormous burden posed by this illness and the significant adverse prognostic impact of cardiac involvement, further research is required to understand the incidence, mechanisms, clinical presentation and outcomes of various CV manifestations in COVID-19 patients. 2020-04-16
Contentious issues and evolving concepts in the clinical presentation and management of patients with COVID-19 infectionwith reference to use of therapeutic and other drugs used in Co-morbid diseases (Hypertension, diabetes etc). We discuss evidence regarding role of chloroquine and hydroxychloroquine in treatment and prophylaxis, use of inhibitors of the renin angiotensin system, safety of ibuprofen, unusual clinical features like gastrointestinal symptoms and interpretation of tests for cardiac enzymes and biomarkers. 2020-04-16
Evolving epidemiology and transmission dynamics of coronavirus disease 2019 outside Hubei province, China: a descriptive and modelling study. Our estimates of the incubation period and serial interval were similar, suggesting an early peak of infectiousness, with possible transmission before the onset of symptoms. 2020-04-05
Delivery of infection from asymptomatic carriers of COVID-19 in a familial cluster. We collected epidemiological and clinical characteristics, laboratory outcomes from electronic medical records, and also affirmed them with the patients and their families. […] Case 2 presented no clinical or radiographic abnormalities. 2020-04-09
Precautions for Operating Room Team Members during the COVID-19 Pandemic. This algorithm is based on urgency of operation, anticipated viral burden at the surgical site, opportunity for a procedure to aerosolize virus, and likelihood a patient could be infected based on symptoms and testing. 2020-04-05
Clinical features of the first cases and a cluster of Coronavirus Disease 2019 (COVID-19) in Bolivia imported from Italy and Spain. Here, we report the main clinical findings, and epidemiological features of the first series of cases, and a cluster, confirmed in Bolivia. […] Nine patients presented fever, and cough, five sore throat, and myalgia, among other symptoms. 2020-04-11
Remdesivir for severe acute respiratory syndrome coronavirus 2 causing COVID-19: An evaluation of the evidence. China has also taken immediate action to put remdesivir into clinical trials with the purpose of applying it into clinical therapeutics for Corona Virus Disease 2019 (COVID-19). 2020-04-14
Use of DAMPs and SAMPs as Therapeutic Targets or Therapeutics: A Note of Caution. Finally, a few clinical examples of how DAMPs and SAMPs might be used as therapeutic targets or therapeutics in the future are discussed, including inhibition of DAMPs in hyperinflammatory processes (e.g., systemic inflammatory response syndrome, as currently observed in Covid-19), administration of SAMPs in chronic inflammatory diseases, inhibition of SAMPs in hyperresolving processes (e.g., compensatory anti-inflammatory response syndrome), and administration/induction of DAMPs in vaccination procedures and anti-cancer therapy. 2020-04-05
Critically ill patients with COVID-19 in Hong Kong: a multicentre retrospective observational cohort study Lower rather than upper respiratory tract viral burden correlates with clinical severity of illness. 2020-04-06
The cardiovascular burden of coronavirus disease 2019 (COVID-19) with a focus on congenital heart disease. Coronavirus disease 2019 (COVID-19), caused by a novel betacoronavirus severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), was first described in a cluster of patients presenting with pneumonia symptoms in Wuhan, China, in December of 2019. […] COVID-19 results in mild symptoms in the majority of infected patients, but can cause severe lung injury, cardiac injury, and death. 2020-04-09
Identification of Kidney Transplant Recipients with Coronavirus Disease 2019. To present the epidemiological, clinical, and therapeutic characteristics of KTx recipients infected with COVID-19, we report on a case series of five patients who were confirmed as having COVID-19 through nucleic acid testing (NAT) from January 1, 2020 to February 28, 2020. […] The most common symptoms on admission to hospital were fever (five patients, 100%), cough (five patients, 100%), myalgia or fatigue (three patients, 60%), and sputum production (three patients, 60%); serum creatinine or urea nitrogen levels were slightly higher than those before symptom onset. 2020-04-06
Recommendations and guidance for providing pharmaceutical care services during COVID-19 pandemic: A China perspective. Pharmacists shall use various approaches to provide PC services in drug dispensing, consulting and referrals, chronic disease management, safe use of infusions, patient education, home care guidance and psychological support to promote the COVID-19 pandemic control and ensure safe medication use of community patients during the pandemic. 2020-04-09
Microneedle array delivered recombinant coronavirus vaccines: Immunogenicity and rapid translational development. We comprehensively tested the pre-clinical immunogenicity of MERS-CoV vaccines in mice when delivered subcutaneously by traditional needle injection, or intracutaneously by dissolving microneedle arrays (MNAs) by evaluating virus specific IgG antibodies in the serum of vaccinated mice by ELISA and using virus neutralization assays. […] Driven by the urgent need for COVID-19 vaccines, we utilized this strategy to rapidly develop MNA SARS-CoV-2 subunit vaccines and tested their pre-clinical immunogenicity in vivo by exploiting our substantial experience with MNA MERS-CoV vaccines. […] Here we describe the development of MNA delivered MERS-CoV vaccines and their pre-clinical immunogenicity. […] Building on our ongoing efforts to develop MERS-CoV vaccines, promising immunogenicity of MNA-delivered MERS-CoV vaccines, and our experience with MNA fabrication and delivery, including clinical trials, we rapidly designed and produced clinically-translatable MNA SARS-CoV-2 subunit vaccines within 4 weeks of the identification of the SARS-CoV-2 S1 sequence. […] Collectively, our results support the clinical development of MNA delivered recombinant protein subunit vaccines against SARS, MERS, COVID-19, and other emerging infectious diseases. 2020-04-16
Macrolide treatment for COVID-19: Will this be the way forward? With no vaccines or drugs approved for prevention and treatment until now, all efforts at drug design and/or clinical trials of already approved drugs are worthy and creditable. 2020-04-06
Maternal and neonatal outcomes of pregnant women with COVID-19 pneumonia: a case-control study. We conducted a case-control study to compare clinical characteristics, maternal and neonatal outcomes of pregnant women with and without COVID-19 pneumonia. […] Few patients presented respiratory symptoms (fever and cough) on admission, but most had typical chest CT images of COVID-19 pneumonia. […] Mild respiratory symptoms of pregnant women with COVID-19 pneumonia highlight the need of effective screening on admission. 2020-04-06
A comparative-descriptive analysis of clinical characteristics in 2019-Coronavirus-infected children and adults. Children and adults show a different clinical course. […] The purpose of the current study is to comparatively analyze the clinical characteristics of 2019-nCoV infection in children and adults and to explore the possible causes for the discrepancies present. […] The medical records of 25 adults and 7 children confirmed cases of 2019-nCoV ARD were reviewed retrospectively. […] In summary, knowledge of these differences between children and adults will not only be helpful for the clinical diagnosis of 2019 novel coronavirus disease (COVID-19), but also for a future discussion on age-specific coronavirus infection. 2020-04-06
COVID-19 infection in a paucisymptomatic infant: Raising the index of suspicion in epidemic settings. Few children have been reported to have been affected by novel coronavirus disease 2019 (COVID-19); it is unclear whether children are less likely to be infected or rather display fewer symptoms. […] We argue that in epidemic settings children presenting with any mild symptom potentially attributable to COVID-19 should be considered contagious until proven otherwise, and that management must be guided by clinical conditions. 2020-04-06
Will plant-made biopharmaceuticals play a role in the fight against COVID-19? The technology to produce plant-made biopharmaceuticals is already established; two examples of these are: a therapeutic enzyme that has entered the market and the influenza vaccines that are currently under clinical trials with encouraging results. […] In particular, plant-made antibodies might be timely produced and approved for human use in the short term, while the development of vaccines will take longer time (clinical evaluations could be concluded by the end of 2021); nonetheless, the candidates obtained will be valuable tools for future outbreaks. 2020-04-16
Potential harmful effects of discontinuing ACE-inhibitors and ARBs in COVID-19 patients. Based on the current clinical evidence treatment with ACE-inhibitors I (ACEis) or angiotensin receptor blockers (ARBs) continues to provide cardiovascular and renal protection in patients diagnosed with COVID-19. 2020-04-15
Conducting Clinical Research During the COVID-19 Pandemic: Investigator and Participant Perspectives. As the medical landscape changes daily with the coronavirus disease (COVID-19) pandemic, clinical researchers are caught off-guard and are forced to make decisions on research visits in their ongoing clinical trials. 2020-04-14
Baseline Characteristics and Outcomes of 1591 Patients Infected With SARS-CoV-2 Admitted to ICUs of the Lombardy Region, Italy. Information about the clinical characteristics of infected patients who require intensive care is limited. […] Demographic and clinical data were collected, including data on clinical management, respiratory failure, and patient mortality. 2020-04-09
Coronavirus disease (COVID-19): Characteristics in children and considerations for dentists providing their care. The COVID-19 epidemiological and clinical characteristics are still being collated but children’s symptoms seem to be milder than those that adults experience. 2020-04-16
A Mobile Health Platform to Disseminate Validated Institutional Measurements During the COVID-19 Outbreak: Utilization-Focused Evaluation Study. On a 10-point Likert scale, the ability of the app to reassure staff in clinical practice was rated as 7.6 (SD 2.1), time-saving ability was rated as 8.5 (SD 2.1), and the need to look for information from other sources was rated as 5.9 (SD 3.3). […] More research should be done on the clinical impact and outcomes of the integration of mHealth solutions as a communication channel of validated information within health institutions. 2020-04-16
Dentists’ Awareness, Perception, and Attitude Regarding COVID-19 and Infection Control: Cross-Sectional Study Among Jordanian Dentists. The questionnaire was comprised of a series of questions about dentists’ demographic characteristics; their awareness of the incubation period, the symptoms of the disease, mode of transmission of COVID-19 and infection control measures for preventing COVID-19; and their attitude toward treating patients with COVID-19. […] The majority of dentists were aware of COVID-19 symptoms and ways of identifying patients at risk of having COVID-19, were able to correctly report known modes of transmission, and were aware of measures for preventing COVID-19 transmission in dental clinics. […] Jordanian dentists were aware of COVID-19 symptoms, mode of transmission, and infection controls and measures in dental clinics. […] National and international guidelines should be sent by the regional and national dental associations to all registered dentists during a crisis, including the COVID-19 pandemic, to make sure that dentists are well informed and aware of best practices and recommended disease management approaches. 2020-04-14
Internet Hospitals Help Prevent and Control the Epidemic of COVID-19 in China: Multicenter User Profiling Study. Symptoms were recorded and compared with reported patients with COVID-19. […] A total of 94.20% (n=4628) of counselees had epidemic-related symptoms with a distribution similar to those of COVID-19. […] Adult counselees (odds ratio [OR]=1.816, P<.001) with epidemiological exposure (OR 7.568, P<.001), shortness of breath (OR 1.440, P=.001), diarrhea (OR 1.272, P=.04), and unrelated symptoms (OR 1.509, P<.001) were more likely to have hypochondriacal suspicion. 2020-04-16
Recommendations for respiratory rehabilitation in adults with COVID-19. Respiratory rehabilitation is an important intervention as well as cure for clinical patients. […] With increased understanding of COVID-19 and the accumulation of clinical experience, we proposed recommendations for respiratory rehabilitation in adults with COVID-19 based on the opinions of frontline clinical experts involved in the management of this epidemic and a review of the relevant literature and evidence. […] Our recommendations are as follows: 1. for inpatients with COVID-19, respiratory rehabilitation would relieve the symptoms of dyspnea, anxiety, and depression and eventually improve physical functions and the quality of life; 2. for severe/critical inpatients, early respiratory rehabilitation is not suggested; 3. for patients in isolation, respiratory rehabilitation guidance should be conducted through educational videos, instruction manuals, or remote consultation; 4. assessment and monitoring should be performed throughout the respiratory rehabilitation process; 5. proper grade protection should be used following the present guidelines. […] These recommendations can guide clinical practice and form the basis for respiratory rehabilitation in COVID-19 patients. 2020-04-13
Lung transplantation as therapeutic option in acute respiratory distress syndrome for COVID-19-related pulmonary fibrosis. The pathological results of the explanted lungs were concordant with the critical clinical manifestation, and provided insight towards better understanding of the disease. 2020-04-06
Current Drugs with Potential for Treatment of COVID-19: A Literature Review. PubMed, Google Scholar and Science Direct databases were searched Results: A total 22 articles were found eligible. 8 discuss about treatment outcomes from their applied drugs during treatment of COVID-19 patients, 4 report laboratory tests, one report animal trial and other 9 articles discuss recommendations and suggestions based on the treatment process and clinical outcomes of other diseases such as malaria, ebola, severe acute respiratory syndrome (SARS) and Middle East respiratory syndrome (MERS). […] All examined treatments, although potentiality effective against COVID-19, need either appropriate drug development or clinical trial to be suitable for clinical use. 2020-04-13
Gastrointestinal Manifestations of SARS-CoV-2 Infection and Virus Load in Fecal Samples from the Hong Kong Cohort and Systematic Review and Meta-analysis. Infection with SARS-CoV-2 causes COVID-19, which has been characterized by fever, respiratory, and gastrointestinal symptoms as well as shedding of virus RNA into feces. […] We performed a systematic review and meta-analysis of published gastrointestinal symptoms and detection of virus in stool, and also summarized data from a cohort of patients with COVID-19 in Hong Kong. […] We analyzed pooled data on the prevalence of overall and individual gastrointestinal symptoms (anorexia, nausea, vomiting, diarrhea, and abdominal pain or discomfort) using a random effects model. […] Among the 59 patients with COVID-19 in Hong Kong, 15 patients (25.4%) had gastrointestinal symptoms and 9 patients (15.3%) had stool that tested positive for virus RNA. […] In a meta-analysis of 60 studies, comprising 4243 patients, the pooled prevalence of all gastrointestinal symptoms was 17.6% (95% CI, 12.3%-24.5%); 11.8% of patients with non-severe COVID-19 had gastrointestinal symptoms (95% CI, 4.1%-29.1%) and 17.1% of patients with severe COVID-19 had gastrointestinal symptoms (95% CI, 6.9%-36.7%). […] In an analysis of data from the Hong Kong cohort of patients with COVID-19 and a meta-analysis of findings from publications, we found that 17.6% of patients with COVID-19 had gastrointestinal symptoms. 2020-04-06
The GReek study in the Effects of Colchicine in COvid-19 complications prevention (GRECCO-19 study): rationale and study design. Colchicine has been utilized safely in a variety of cardiovascular clinical conditions. […] Among its potential mechanisms of action is the non-selective inhibition of NLRP3 inflammasome which is thought to be a major pathophysiologic component in the clinical course of patients with COVID-19. […] Patients with laboratory confirmed SARS-CoV-2 infection (under RT PCR) and clinical picture that involves temperature >37.5 oC and at least two out of the: i. sustained coughing, ii. sustained throat pain, iii. […] GRECCO-19 trial aims to identify whether colchicine may positively intervene in the clinical course of COVID-19. 2020-04-06
Structural and molecular modelling studies reveal a new mechanism of action of chloroquine and hydroxychloroquine against SARS-CoV-2 infection. This domain (111-158), which is fully conserved among clinical isolates worldwide, may improve attachment of the virus to lipid rafts and facilitate contact with the ACE-2 receptor. […] The in-silico approaches used in this study might also be used to assess the efficiency of a broad range of repositioned and/or innovative drug candidates before clinical evaluation. 2020-04-14
Remdesivir, lopinavir, emetine, and homoharringtonine inhibit SARS-CoV-2 replication in vitro. We evaluated the in vitro antiviral effect of compounds that were previously reported to inhibit coronavirus replication and compounds that are currently under evaluation in clinical trials for SARS-CoV-2 patients. […] Ribavirin or favipiravir that are currently evaluated under clinical trials showed no inhibition at 100 μM. […] Combinational therapy may help to reduce the effective concentration of compounds below the therapeutic plasma concentrations and provide better clinical benefits. 2020-04-16
The FDA-approved Drug Ivermectin inhibits the replication of SARS-CoV-2 in vitro. Although several clinical trials are now underway to test possible therapies, the worldwide response to the COVID-19 outbreak has been largely limited to monitoring/containment. 2020-04-09
Severe Acute Respiratory Syndrome (SARS) and Coronavirus disease-2019 (COVID-19): From Causes to Preventions in Hong Kong. To prevent further outbreak of COVID-19, this article discusses the current understanding of COVID-19 and compares with the outbreak of SARS-CoV-2 in 2003 of Hong Kong from the causes, transmission, symptoms, diagnosis, treatments and preventions to study for an applicable measurement to control COVID-19. 2020-04-06
A first Case of Meningitis/Encephalitis associated with SARS-Coronavirus-2. This case warns the physicians of patients who have CNS symptoms. 2020-04-06
Extracorporeal membrane oxygenation (ECMO): does it have a role in the treatment of severe COVID-19? In this study, we described and discussed the clinical outcomes of ECMO for ARDS patients, ECMO use for severe COVID-19 in China, the indications of ECMO use, and some important issues associated with ECMO. 2020-04-06
Clinical characteristics of 25 death cases with COVID-19: a retrospective review of medical records in a single medical center, Wuhan, China. This study aims to summarize the clinical characteristics of death cases with COVID-19 and to identify critically ill patients of COVID-19 early and reduce their mortality. […] The clinical records, laboratory findings and radiological assessments included chest X-ray or computed tomography were extracted from electronic medical records of 25 died patients with COVID-19 in Renmin Hospital of Wuhan University from Jan 14 to Feb 13, 2020. […] The clinical characteristics of 25 death cases with COVID-19 we summarized, which would be helpful to identify critically ill patients of COVID-19 early and reduce their mortality. 2020-04-09
Clinical characteristics of non-critically ill patients with novel coronavirus infection (COVID-19) in a Fangcang Hospital. Describe the clinical characteristics of patients in Fangcang Hospital. […] Non-critically ill patients with positive SARS-CoV-2 RT-PCR tests admitted to Dongxihu ‘Fangcang’ Hospital between February 7th and 12th were included, which was promptly constructed because of the rapid, exponential increase in COVID-19 patients in Wuhan, China; clinical course through February 22nd was recorded. 1012 non-critically ill patients with positive SARS-CoV-2 RT-PCR tests were included in the study. 30 (of 1012, 3.0%) patients were asymptomatic on admission. […] During hospitalization, 16 of 30 (53.3%) asymptomatic patients suffered from different symptoms. […] Fever (761 of 1012, 75.2%) and cough (531 of 1012, 52.4%) were the most common symptoms. […] Non-critically ill patients had different clinical characteristics than critically ill patients. 2020-04-06
Interpreting COVID-19 and Virtual Care Trends: Cohort Study. The aim of this study was to explore the trends in confirmed COVID-19 cases in North Carolina, and to understand patterns in virtual visits related to symptoms of COVID-19. […] Of the total visits, 257 (35.1%) were related to COVID-19-like symptoms. 2020-04-16
Epidemiology, virology, and clinical features of severe acute respiratory syndrome -coronavirus-2 (SARS-CoV-2; Coronavirus Disease-19). The purpose of this review is to summarize known-to-date information about SARS-CoV-2, transmission of SARS-CoV-2, and clinical features. 2020-04-17
Evidence that Vitamin D Supplementation Could Reduce Risk of Influenza and COVID-19 Infections and Deaths. Several observational studies and clinical trials reported that vitamin D supplementation reduced the risk of influenza, whereas others did not. 2020-04-10
COVID-19 and the Heart. Infection with the novel coronavirus, SARS-CoV-2, produces a clinical syndrome known as COVID-19. 2020-04-15
CT imaging changes of corona virus disease 2019(COVID-19): a multi-center study in Southwest China. Their common clinical manifestations, as well as characteristics and evolvement features of chest CT images, were analyzed. […] The clinical manifestations of COVID-19 included cough, fever. 2020-04-10
Adaptation of the National Plan for the Prevention and Fight Against Pandemic Influenza to the 2020 COVID-19 epidemic in France. This extreme measure never seen before during peace time was the result of adapting not only the French Pandemic Influenza Plan (PIP) being applied to the national context but also real-time clinical, epidemiological and scientific information about the evolution of COVID-19 infection in the country. 2020-04-07
Recommendations for coronavirus infection in rheumatic diseases treated with biologic therapy. SARS-CoV2 spread from China where the first infections were described in December 2019 and is responsible for the respiratory symptoms that can lead to acute respiratory distress syndrome. 2020-04-15
Hepatic and gastrointestinal involvement in coronavirus disease 2019 (COVID-19): What do we know till now? This involvement may have important implications to the disease management, transmission, and prognosis, especially in patients with pre-existing hepatic or digestive co-morbidities. 2020-04-07
Effectiveness of convalescent plasma therapy in severe COVID-19 patients. The second endpoints were the improvement of clinical symptoms and laboratory parameters within 3 d after CP transfusion. […] The clinical symptoms were significantly improved along with increase of oxyhemoglobin saturation within 3 d. […] This study showed CP therapy was well tolerated and could potentially improve the clinical outcomes through neutralizing viremia in severe COVID-19 cases. […] The optimal dose and time point, as well as the clinical benefit of CP therapy, needs further investigation in larger well-controlled trials. 2020-04-07
Impact of the COVID-19 pandemic on urology residency training in Italy. To provide insights on this issue, a 25-items online Survey was sent to all Italian residents one month after the first case of COVID-19 in Italy, to evaluate their routine involvement in “clinical” (on-call duty, outpatient visits, diagnostic procedures) and “surgical” (endoscopic, open and minimally invasive surgery) training activities before and during the COVID-19 period. […] Before the COVID-19 pandemic, the proportion of residents routinely involved in “clinical” and “surgical” activities ranged from 79.8% to 87.2% and from 49.3% to 73.5%, respectively. […] In the COVID-19 period, the proportion of residents experiencing a severe reduction (>40%) or complete suppression (>80%) of training exposure ranged between 41.1% and 81.2% for “clinical” activities while between 44.2% and 62.1% for “surgical” activities. 2020-04-07
Correction to: Clinical predictors of mortality due to COVID-19 based on an analysis of data of 150 patients from Wuhan, China. Clinical predictors of mortality due to COVID-19 based on an analysis of data of 150 patients from Wuhan, China. 2020-04-09
Olfactory and gustatory dysfunctions as a clinical presentation of mild-to-moderate forms of the coronavirus disease (COVID-19): a multicenter European study. The following epidemiological and clinical outcomes have been studied: age, sex, ethnicity, comorbidities, and general and otolaryngological symptoms. […] The most prevalent general symptoms consisted of cough, myalgia, and loss of appetite. […] Face pain and nasal obstruction were the most disease-related otolaryngological symptoms. […] Olfactory dysfunction (OD) appeared before the other symptoms in 11.8% of cases. […] Olfactory and gustatory disorders are prevalent symptoms in European COVID-19 patients, who may not have nasal symptoms. […] The sudden anosmia or ageusia need to be recognized by the international scientific community as important symptoms of the COVID-19 infection. 2020-04-07
Tocilizumab treatment in COVID-19: A single center experience. The demographic, treatment, laboratory parameters of C-reactive protein (CRP) and IL-6 before and after TCZ therapy and clinical outcome in the 15 COVID-19 patients were retrospectively assessed. […] Although TCZ treatment ameliorated the increased CRP in all patients rapidly, for the four critically ill patients who received an only single dose of TCZ, three of them (No. 1, 2, and 3) still dead and the CRP level in the rest one patient (No. 7) failed to return to normal range with a clinical outcome of disease aggravation. 2020-04-15
Daily medical education for confined students during COVID-19 pandemic: a simple videoconference solution. This video conference method can be applied to clinical as well as anatomy lessons. 2020-04-07
[Thoughts on the reform of preventive medicine education in the context of new medicine]. A series of specific suggestions are put forward including the establishment of a full-chain closed-loop research system to support the cultivation of top-notch innovative public health talents, strengthening the assessment of core public health capabilities for clinical medical professional admission, formulating a “medical and preventive integration” training program for primary health personnel, and implementing “combination of peace and war” public health personnel reserve system, with the purpose of providing reference for the reform and development of preventive medical education in China. 2020-04-07
Deployment of convalescent plasma for the prevention and treatment of COVID-19. Convalescent plasma has also been used in the COVID-19 pandemic; limited data from China suggest clinical benefit, including radiological resolution, reduction in viral loads and improved survival. […] Data from rigorously controlled clinical trials of convalescent plasma are also few, underscoring the need to evaluate its use objectively for a range of indications (e.g., prevention vs treatment) and patient populations (e.g., age, comorbid disease). […] We provide an overview of convalescent plasma, from evidence of benefit, regulatory considerations, logistical work flow and proposed clinical trials, as scale up is brought underway to mobilize this critical resource. . 2020-04-07
Hospitalization and Critical Care of 109 Decedents with COVID-19 Pneumonia in Wuhan, China. Demographic, clinical, laboratory, and treatment data were collected and analyzed, and final date of follow-up was February 24, 2020. […] Our findings should aid in the recognition and clinical management of such infections, especially ICU resource allocation. 2020-04-07
The Role of Chest Imaging in Patient Management during the COVID-19 Pandemic: A Multinational Consensus Statement from the Fleischner Society. Fourteen key questions, corresponding to 11 decision points within the three scenarios and three additional clinical situations, were rated by the panel based upon the anticipated value of the information that thoracic imaging would be expected to provide. 2020-04-08
Radiographic and Clinical Features of Children with 2019 Novel Coronavirus (COVID-19) Pneumonia. The chest CT images and clinical data were reviewed. […] The most prevalent presenting symptoms were fever (64%) and cough (59%), and a mildly elevated mean (SD) C-reactive protein (CRP) level of 11.22(11.06) and erythrocyte sedimentation rate of 18.8 (15.17) were detected. […] Children with COVID-19 had relatively milder symptoms and less severe lung inflammation than adults. 2020-04-07
Towards Optimization of Hydroxychloroquine Dosing in Intensive Care Unit COVID-19 Patients. However, all ongoing clinical trials with HCQ use different dosing regimens, resulting on various concentrations PK studies are therefore needed to define the optimal dosing regimen. 2020-04-07
COVID-19 and the use of immunomodulatory and biologic agents for severe cutaneous disease: An Australia/New Zealand consensus statement. In patients who develop symptoms or signs of an upper respiratory tract infection, but COVID-19 is not yet confirmed, consider dose reduction or temporarily cessation for 1-2 weeks. 2020-04-07
Informing Emergency Care for COVID-19 patients: The COVID-19 Emergency Department (COVED) Quality Improvement Project Protocol. The COVID-19 Emergency Department (COVED) Quality Improvement Project has commenced and will provide flexible and responsive clinical tools to determine the predictors of key ED-relevant clinical outcomes. […] Regression methodology will be used to generate clinical prediction tools. 2020-04-07
A Community Letter Regarding Sharing Bimolecular Simulation Data for COVID-19. Sharing of data for COVID-19 applications will help connect scientists across the global biomolecular simulation community, and also improve connection and communication between simulation and experimental and clinical data and investigators. 2020-04-07
Clinical trials on drug repositioning for COVID-19 treatment. More than 80 clinical trials have been launched to test coronavirus treatment, including some drug repurposing or repositioning for COVID-19. […] The eligibility criteria for the retrieved studies were: contain a base identifier number; describe the number of participants and the period for the study; describe the participants’ clinical conditions; and utilize interventions with medicines already studied or approved for any other disease in patients infected with the novel coronavirus SARS-CoV-2 (2019-nCoV). […] We identified 24 clinical trials, involving more than 20 medicines, such as human immunoglobulin, interferons, chloroquine, hydroxychloroquine, arbidol, remdesivir, favipiravir, lopinavir, ritonavir, oseltamivir, methylprednisolone, bevacizumab, and traditional Chinese medicines (TCM). […] Although drug repurposing has some limitations, repositioning clinical trials may represent an attractive strategy because they facilitate the discovery of new classes of medicines; they have lower costs and take less time to reach the market; and there are existing pharmaceutical supply chains for formulation and distribution. 2020-04-09
Associations between immune-suppressive and stimulating drugs and novel COVID-19-a systematic review of current evidence. The mycophenolate mofetil picture is less clear, with conflicting data from pre-clinical studies. 2020-04-09
COVID-19 and treatment with NSAIDs and corticosteroids: should we be limiting their use in the clinical setting? There have been a number of reports stating that non-steroidal anti-inflammatory drugs (NSAIDs) and corticosteroids may exacerbate symptoms in COVID-19 patients. 2020-04-09
An evidence-based framework for priority clinical research questions for COVID-19. Outbreaks of novel agents represent opportunities for clinical research to inform real-time public health action. […] Here, we review information available on COVID-19 and provide an evidenced-based framework for priority clinical research in the current outbreak. […] Three bibliographic databases were searched to identify clinical studies published on SARS-CoV and MERS-CoV in the outbreak setting. […] Studies were grouped thematically according to clinical research questions addressed. […] From the research objectives for SARS-CoV and MERS-CoV, ten themes in the literature were identified: Clinical characterisation, prognosis, diagnosis, clinical management, viral pathogenesis, epidemiological characterisation, infection prevention and control/transmission, susceptibility, psychosocial, and aetiology. […] For COVID19, some information on clinical presentation, diagnostic testing, and aetiology is available but many clinical research gaps have yet to be filled. […] Based on a systematic review of other severe coronaviruses, we summarise the state of clinical research for COVID-19, highlight the research gaps, and provide recommendations for the implementation of standardised protocols. […] Data based on internationally standardised protocols will inform clinical practice real-time. 2020-04-15
COVID-19 infection: Origin, transmission, and characteristics of human coronaviruses. However, few broad-spectrum antiviral drugs have been evaluated against COVID-19 in clinical trials, resulted in clinical recovery. 2020-04-09
Transplantation of ACE2- Mesenchymal Stem Cells Improves the Outcome of Patients with COVID-19 Pneumonia. The clinical outcomes, as well as changes of inflammatory and immune function levels and adverse effects of 7 enrolled patients were assessed for 14 days after MSC injection. […] The pulmonary function and symptoms of these seven patients were significantly improved in 2 days after MSC transplantation. 2020-04-09
Mesenchymal Stem Cell Infusion Shows Promise for Combating Coronavirus (COVID-19)- Induced Pneumonia. A new study published by the journal Aging & Disease reported that intravenous administration of clinical-grade human mesenchymal stem cells (MSCs) into patients with coronavirus disease 2019 (COVID-19) resulted in improved functional outcomes (Leng et al., Aging Dis, 11:216-228, 2020). 2020-04-09
Coronavirus Disease (COVID-19) and Pediatric Patients: A Review of Epidemiology, Symptomatology, Laboratory and Imaging Results to Guide the Development of a Management Algorithm. This article looks to review specific epidemiological factors, symptomatology, laboratory and imaging workup, and other relevant metrics derived from the limited published literature that are specific to the pediatric population, to provide a review for the pediatric practitioner and guide, in part, the creation of a clinical algorithm for the management of COVID-19 in the pediatric population that can be utilized by pediatric institutions. 2020-04-09
Current knowledge about the antivirals remdesivir (GS-5734) and GS-441524 as therapeutic options for coronaviruses. Remdesivir (GS-5734™) is a broad-spectrum antiviral drug that is now being tested as a potential treatment for COVID-19 in international, multi-site clinical trials. […] As the pandemic progresses, information from human compassionate use cases will continue to accumulate before the clinical trials are concluded. 2020-04-07
Epidemiological and Clinical Aspects of COVID-19; a Narrative Review. There are significant misconceptions and many obstacles in the way of illuminating the epidemiological and clinical aspects of COVID-19 as a new emerging epidemic. […] However, misinterpreting or ignoring strong evidence in clinical practice and public health probably results in less effective and somehow more harmful decisions for individuals as well as subgroups in general populations of countries in the initial stages of this epidemic. […] Accordingly, our narrative review appraised epidemiological and clinical aspects of the disease including genetic diversity of coronavirus genus, mode of transmission, incubation period, infectivity, pathogenicity, virulence, immunogenicity, diagnosis, surveillance, clinical case management and also successful measures for preventing its spread in some communities. 2020-04-09
Locally Informed Simulation to Predict Hospital Capacity Needs During the COVID-19 Pandemic. The coronavirus disease 2019 (COVID-19) pandemic challenges hospital leaders to make time-sensitive, critical decisions about clinical operations and resource allocations. […] To estimate the timing of surges in clinical demand and the best- and worst-case scenarios of local COVID-19-induced strain on hospital capacity, and thus inform clinical operations and staffing demands and identify when hospital capacity would be saturated. 2020-04-15
Pain Management Best Practices from Multispecialty Organizations during the COVID-19 Pandemic and Public Health Crises. Although this document provides a framework for pain management services, systems-wide and individual decisions must take into account clinical considerations, regional health conditions, government and hospital directives, resource availability, the welfare of health care providers. 2020-04-07
Maternal and Perinatal Outcomes with COVID-19: a systematic review of 108 pregnancies. The objective of this study was to summarize the clinical manifestations and maternal and perinatal outcomes of COVID-19 during pregnancy. […] Multiple terms and combinations were used including COVID-19, pregnancy, maternal mortality, maternal morbidity, complications, clinical manifestations, neonatal morbidity, intrauterine fetal death, neonatal mortality and SARS-CoV-2. […] Data on clinical manifestations, maternal and perinatal outcomes including vertical transmission were extracted and analyzed. 2020-04-07
Review of Emerging Pharmacotherapy for the Treatment of Coronavirus Disease 2019. Therapies include novel agents available in clinical trials or through compassionate use, and other drugs, repurposed antiviral and immune modulating therapies. […] The purpose of this review is to summarize practical considerations for pharmacotherapy in patients with COVID-19, with the intent of serving as a resource for health care providers at the forefront of clinical care during this pandemic. 2020-04-07
Clinical Characteristics of COVID-19 After Gynecologic Oncology Surgery in Three Women: A Retrospective Review of Medical Records. From a large medical center in Wuhan, the epicenter of the 2019 novel coronavirus disease (COVID-19), we report clinical features and prognosis for three women diagnosed with COVID-19 after gynecologic oncology surgery and hospitalized in January 2020. […] By February 20, 2020, only two of the three patients had met the clinical discharge criteria. 2020-04-13
Novel coronavirus infection in children outside of Wuhan, China. Epidemiological and clinical data of these children were collected and analyzed. […] The initial symptoms of the nine children were mild, including fever (3/9), diarrhea (2/9), cough (1/9), and sore throat (1/9), two had no symptoms. […] The clinical symptoms of the new coronavirus infection in children were not typical and showed a less aggressive clinical course than teenage and adult patients. 2020-04-07
Calculated decisions: COVID-19 calculators during extreme resource-limited situations. Clinical decision scores may support the clinician’s decision-making, especially if properly adapted for this unique pandemic and for the patient being treated. […] This review discusses the use of clinical prediction scores for pneumonia severity at 3 main decision points to examine which scores may provide value in this unique situation. […] Initial data from a cohort of over 44,000 COVID-19 patients in China, including risk factors for mortality, were compared with data from cohorts used to study the clinical scores, in order to estimate the potential appropriateness of each score and determine how to best adjust results at the bedside. 2020-04-09
Risk of nosocomial transmission of coronavirus disease 2019: an experience in a general ward setting in Hong Kong. Respiratory specimens were collected from contacts who developed fever, and/or respiratory symptoms during the surveillance period and were tested for SARS-CoV-2. 2020-04-09
Nuclear medicine in SARS-CoV-2 pandemia: 18F-FDG-PET/CT to visualize COVID-19. Diagnosis relies on clinical presentation, exposure history, PCR using specimens from the respiratory tract together with computed tomography (CT) imaging. 2020-04-07
Urgent need for individual mobile phone and institutional reporting of at home, hospitalized, and intensive care unit cases of SARS-CoV-2 (COVID-19) infection. It is known that many test-positive individuals may not develop symptoms or have a mild self-limited viral syndrome consisting of fever, malaise, dry cough, and constitutional symptoms. 2020-04-10
Wearable Cardiorespiratory Monitoring Employing a Multimodal Digital Patch Stethoscope: Estimation of ECG, PEP, LVETand Respiration Using a 55 mm Single-Lead ECG and Phonocardiogram. In the clinical routine, prolonged postanesthetic respiratory instability worsens the patient outcome. 2020-04-10
In Vitro Diagnostic Assays for COVID-19: Recent Advances and Emerging Trends. However, the performance of IVD assays needs to be critically evaluated before they are employed for the clinical diagnosis of COVID-19. 2020-04-08
Childhood Rheumatic Diseases and COVID-19 Pandemic: An Intriguing Linkage and a New Horizon The clinical features were on a large scale that varies from being an asymptomatic carrier to acute respiratory distress syndrome and multiorgan dysfunction. […] Fever, dry cough and fatigue are the most common symptoms. 2020-04-08
Angiotensin Converting Enzyme 2: SARS-CoV-2 Receptor and Regulator of the Renin-Angiotensin System. Recombinant human ACE2 has completed clinical trials and efficiently lowered or increased plasma angiotensin II and angiotensin 1-7 levels, respectively. 2020-04-08
Surgery in COVID-19 patients: operational directives. We aim to describe recommended clinical pathways for COVID-19-positive patients requiring acute non-deferrable surgical care. 2020-04-10
Coronavirus Disease (COVID-19): A primer for emergency physicians. Symptoms of COVID-19 are similar to other viral upper respiratory illnesses. […] Three major trajectories include mild disease with upper respiratory symptoms, non-severe pneumonia, and severe pneumonia complicated by acute respiratory distress syndrome (ARDS). […] Disposition depends on patient symptoms, hemodynamic status, and patient ability to self-quarantine. 2020-04-10
Should chloroquine and hydroxychloroquine be used to treat COVID-19? A rapid review. A number of in vivo clinical trials are underway. […] High quality, adequately powered randomised clinical trials in primary and secondary care settings are urgently required to guide policymakers and clinicians. 2020-04-08
Ocular manifestations of a hospitalised patient with confirmed 2019 novel coronavirus disease. Precautionary measures are recommended when examining infected patients throughout the clinical course of the infection. 2020-04-08
Prediction models for diagnosis and prognosis of covid-19 infection: systematic review and critical appraisal. The most reported predictors of presence of covid-19 in patients with suspected disease included age, body temperature, and signs and symptoms. […] Methodological guidance should be followed because unreliable predictions could cause more harm than benefit in guiding clinical decisions. 2020-04-10
Current Status of Cell-Based Therapies for Respiratory Virus Infections: Applicability to COVID-19. Limited pre-clinical data suggest that systemic MSC administration can significantly reduce respiratory virus (Influenza strains H5N1 and H9N2)-induced lung injury, however, there are no available data in models of coronavirus respiratory infection.There are a rapidly increasing number of clinical investigations of cell-based therapy approaches for COVID-19. […] To provide a rationale strategy to maximise potential therapeutic use, it is critically important to understand the relevant pre-clinical studies and postulated mechanisms of MSC actions in respiratory virus-induced lung injuries. […] These are presented along with consideration of current clinical investigations. 2020-04-10
Obstetric Anesthesia During the COVID-19 Pandemic. The goal of this review is to provide evidence-based recommendations, or expert opinion when evidence is limited, for anesthesiologists caring for pregnant women during the COVID 19 pandemic, with a focus on preparedness and best clinical obstetric anesthesia practice. 2020-04-08
Coronavirus Disease 2019 in Critically Ill Children: A Narrative Review of the Literature. In the 3 months since its emergence, we have learned a great deal about its clinical management and its relevance to the pediatric critical care provider. […] In this article, we review the available literature and provide valuable insight into the clinical management of this disease, as well as information on preparedness activities that every PICU should perform. 2020-04-08
Infants Born to Mothers With a New Coronavirus (COVID-19). None of the infants developed serious clinical symptoms such as fever, cough, diarrhea, or abnormal radiologic or hematologic evidence, and all four infants were alive at the time of hospital discharge. […] This case report describes the clinical course of four live born infants, born to pregnant women with the COVID-19 infection. 2020-04-10
Corticosteroid treatment of patients with coronavirus disease 2019 (COVID-19). Virus clearance time, length of hospital stay, and duration of symptoms, by treatment type (including or not including corticosteroid therapy). […] Cox proportional hazards regression analysis indicated no association between corticosteroid treatment and virus clearance time (hazard ratio [HR], 1.26; 95% CI, 0.58-2.74), hospital length of stay (HR, 0.77; 95% CI, 0.33-1.78), or duration of symptoms (HR, 0.86; 95% CI, 0.40-1.83). 2020-04-08
Special considerations for the management of COVID-19 pediatric patients in the operating room and pediatric intensive care unit in a tertiary hospital in Singapore. The pediatric population has been found to be less susceptible to the disease with the majority of children having milder symptoms and only one pediatric death being reported globally so far. 2020-04-08
Continuous Intravenous Anakinra Infusion to Calm the Cytokine Storm in Macrophage Activation Syndrome. Demographic, clinical, laboratory characteristics and outcomes were recorded. […] Continuous IV anakinra infusions up to 2400 mg/day resulted in rapid serologic, then clinical response in 4/5 severely ill patients who were refractory to all other therapies including subcutaneous anakinra. […] Continuous infusion of IV anakinra may result in rapid serologic and subsequent clinical improvement in adult patients with MAS. 2020-04-08
Digestive system involvement of novel coronavirus infection: prevention and control infection from a gastroenterology perspective. As the natural history and variety of clinical presentations of this disease unfolds, the extrapulmonary symptoms of the disease have emerged, especially the symptoms related to the digestive system. […] While the respiratory mode of transmission is well-known and likely the principal mode of transmission of this disease, the possibility of the fecal-oral route of transmission has also emerged in various case series and clinical scenario. 2020-04-08
[COVID-19 andcardiovascular diseases]. Also, due to the growing number of infected cases, it is clear that, in addition to the typical respiratory symptoms caused by the infection, some patients suffer from cardiovascular damage. 2020-04-09
COVID-19 Obstetrics Task Force, Lombardy, Italy: executive management summary and short report of outcome. The vision of this strict organization was to centralize patients in high-risk maternity centers in order to concentrate human resources and personal protective equipment (PPE), dedicate protected areas of these major hospitals, and centralize clinical multidisciplinary experience with this disease. […] The clinical presentation was interstitial pneumonia in 20 women. 2020-04-08
COVID-19: Important Therapy Considerations and Approaches in this Hour of Need. A number of novel and repurposed therapies agents with activity against SARS-CoV-2 have been identified and most institutions have developed clinical pathways to operationalize their use in appropriate COVID-19 patients.1-3 However, optimal drug therapy decisions for those with moderate to severe COVID-19 infections are extremely challenging at this time as evidence is limited. 2020-04-08
Research disruptions and recovery. As a consequence, many of us who undertake clinical research have seen our work suspended. 2020-04-08
The Randomized Embedded Multifactorial Adaptive Platform for Community-acquired Pneumonia (REMAP-CAP) Study: Rationale and Design. Clinical trial registered with (NCT02735707). 2020-04-09
Infection control in non-clinical areas during COVID-19 pandemic. Therefore, we believe non-clinical areas are potentially high-risk for transmission between healthcare workers, and often neglected by infection prevention and control protocols. […] To alert others to this risk and how it may be reduced, we describe our non-clinical workplace infection prevention and control measures that have been modified from those originally developed during the 2003 severe acute respiratory syndrome epidemic [5]. 2020-04-08
COVID-19: The Uninvited Guest in the Intensive Care Unit (ICU) Implications for Pharmacotherapy. Initially, the estimate for severe cases was approximated at 5% based on experience from China.1, 2 However, the World Health Organization’s (WHO) estimate from China for severe and critical cases is near 20% (Table).3 The primary clinical feature of COVID-19 is pneumonia, the severity of which directs the clinical course; it has been estimated that, of patients admitted to the ICU, up to half may require either invasive or non-invasive ventilatory support.4 This has created an unprecedented situation for emergency and critical care medicine. 2020-04-08
Immune responses and pathogenesis of SARS-CoV-2 during an outbreak in Iran: Comparison with SARS and MERS. Fever, cough, and fatigue were the most common symptoms of this virus. […] Laboratory evidence of clinical patients showed that a specific T-cell response against SARS-CoV-2 is important for the recognition and killing of infected cells, particularly in the lungs of infected individuals. 2020-04-08
Hydroxychloroquine for treatment of SARS-CoV-2 infection? Improving our confidence in a model-based approach to dose selection. It has been reported that hydroxychloroquine (HCQ) is active against SARS-CoV-2 in vitro, and this finding was quickly supported by an open label non-randomized clinical trial that provided the first published clinical evidence HCQ may be a treatment option. 2020-04-11
Responding to COVID-19: The UW Medicine Information Technology Services Experience. Here we describe the rapid rollout of capabilities by UW Medicine Information Technology Services (ITS) to support our clinical response to the COVID-19 pandemic and provide recommendations for health systems to urgently consider, as they plan their own response to this and potentially other future pandemics. […] We look at how we managed expedited change control processes to quickly update electronic health records (EHR) with new COVID-19 laboratory and clinical workflows. […] The COVID-19 response requires new and expedited ways of approaching ITS support to clinical needs. […] UW Medicine ITS leadership hope that by quickly sharing our nimble response to clinical and operational requests, we can help other systems prepare to respond to this public health emergency. 2020-04-13
[Work flow of clinical microbiology laboratory under the outbreak of the novel coronavirus disease 2019]. The burn microbiology laboratory of the author’s unit is a second-level biosafety laboratory, which is mainly responsible for handling clinical microbial samples from our department and other departments in the hospital. […] The specific work flow is summarized as follows to provide reference for the safety protection of peer in clinical microbiology laboratory. 2020-04-08
[Clinical application effect of modified nasopharyngeal swab sampling for 2019 novel coronavirus nucleic acid detection]. Objective: To study the clinical application effect of modified nasopharyngeal swab sampling for 2019 novel coronavirus nucleic acid detection. Methods: This study covered the period from January 14 to March 1, 2020. 2020-04-08
[Health protection guideline of mobile cabin hospitals during COVID-19 outbreak]. This guideline is applicable to the health protection requirements of large indoor stadiums which are reconstructed as treatment sites for COVID-19 patients with mild symptoms during the outbreak. 2020-04-10
[The network investigation on knowledge, attitude and practice about COVID-19 of the residents in Anhui Province]. Residents had higher awareness rate of cough (99.5%,n=3 997) and fever (96.0%, n=3 857) symptoms, the transmission by droplets (99.5%, n=3 995), aerosol transmission (81.1%, n=3 258), and contact transmission (92.3%, n=3 708), but lower awareness of symptoms os muscle pain or fatigue (62.7%, n=2 518). 2020-04-10
Chinese Society of Anesthesiology Expert Consensus on Anesthetic Management of Cardiac Surgical Patients With Suspected or Confirmed Coronavirus Disease 2019. Based on the current understanding of COVID-19 and the clinical characteristics of cardiovascular surgical patients, the authors provide anesthesia management guidelines for cardiovascular surgery along with the prevention and control of COVID-19. 2020-04-11
Clinical characteristics and outcomes of hospitalised patients with COVID-19 treated in Hubei (epicenter) and outside Hubei (non-epicenter): A Nationwide Analysis of China. We sought to compare the clinical characteristics and outcomes of patients being treated inside and outside Hubei province, and explore the factors underlying these differences. […] Clinical characteristics, the rate of severe events and deaths, and the time to critical illness (invasive ventilation or intensive care unit admission or death) were compared between patients in and outside of Hubei. 2020-04-11
Novel Coronavirus Infection in Newborn Babies Under 28 Days in China. Previous studies described the clinical features of Covid-19 in adults and infants under 1 year of age. […] All 4 mothers were infected by SARS-CoV-2, 3 showing symptoms before and 1 after delivery. […] The symptoms in newborn babies were milder and outcomes were less severe as compared to adults. 2020-04-11
Predictors of Mortality for Patients with COVID-19 Pneumonia Caused by SARS-CoV-2: A Prospective Cohort Study. All clinical and laboratory parameters were collected prospectively from a cohort of patients with COVID-19 pneumonia who were hospitalised to Wuhan Pulmonary Hospital, Wuhan City, Hubei Province, China, between December 25, 2019 and February 7, 2020. 2020-04-11
Comparative Performance of SARS-CoV-2 Detection Assays using Seven Different Primer/Probe Sets and One Assay Kit. In the course of optimizing SARS-CoV-2 testing performed by the University of Washington Clinical Virology Lab (UW Virology Lab), we evaluated assays using seven different primer/probe sets and one assay kit. […] These results will provide valuable information to other clinical laboratories who are actively developing SARS-CoV-2 testing protocols at a time when increased testing capacity is urgently needed worldwide. 2020-04-09
Resource Allocation and Decision Making for Pediatric and Congenital Cardiac Catheterization During the Novel Coronavirus SARS-CoV-2 (COVID-19) Pandemic: A U.S. Multi-Institutional Perspective. Currently, only a small fraction of operators has been reassigned to provide clinical services outside their scope of practice. 2020-04-09
Anosmia and ageusia are emerging as symptoms in patients with COVID-19: What does the current evidence say? There have been several reports noting anosmia and ageusia as possible symptoms of COVID-19. […] This is of particular interest in oncology since patients receiving some cancer treatments such as chemotherapy or immune therapy often experience similar symptoms as side-effects. […] The purpose of this report was to summarise the evidence on the existence of anosmia and ageusia an emerging COVID-19 symptoms in order to better inform both oncology patients and clinicians. […] Currently, there is no published evidence or case reports noting anosmia or ageusia as symptoms of COVID-19. […] Nevertheless, experts in rhinology have suggested that the onset of such symptoms could either act as a trigger for testing for the disease where possible, or could be a new criterion to self-isolate. […] Whilst more data is currently needed to strengthen our knowledge of the symptoms of COVID-19, oncology patients who are concerned about anosmia or ageusia in the context of their systemic anti-cancer therapy should contact their acute oncology support line for advice. 2020-04-09
A Comprehensive Literature Review on the Clinical Presentation, and Management of the Pandemic Coronavirus Disease 2019 (COVID-19). There are multiple parameters of the clinical course and management of the COVID-19 that need optimization. […] This literature review aims to presents accredited and the most current studies pertaining to the basic sciences of SARS-CoV-2, clinical presentation and disease course of COVID-19, public health interventions, and current epidemiological developments. […] The review on basic sciences aims to clarify the jargon in virology, describe the virion structure of SARS-CoV-2 and present pertinent details relevant to clinical practice. […] Additionally, the clinical and epidemiological differences between COVID-19 and other infections causing outbreaks (SARS, MERS, H1N1) are elucidated. […] Emphasis is placed on evidence-based medicine to evaluate the frequency of presentation of various symptoms to create a stratification system of the most important epidemiological risk factors for COVID-19. […] Furthermore, the limitations and statistical strength of the diagnostic tools currently in clinical practice are evaluated. […] Furthermore, the biochemistry of the major candidates for novel therapies is briefly reviewed and a summary of their current status in the clinical trials is presented. 2020-04-11
Comparative replication and immune activation profiles of SARS-CoV-2 and SARS-CoV in human lungs: an ex vivo study with implications for the pathogenesis of COVID-19. Although SARS-CoV-2 and SARS-CoV share a number of common clinical manifestations, SARS-CoV-2 appears to be highly efficient in person-to-person transmission and frequently cause asymptomatic infections. 2020-04-09
Acute stroke management pathway during Coronavirus-19 pandemic. However, to remain at home with stroke symptoms does not mean to “stay safe at home”. 2020-04-11
Coronavirus: Update Related to the Current Outbreak of COVID-19. Along with severe acute respiratory syndrome (SARS) and Middle Eastern respiratory syndrome (MERS), COVID-19 appears to cause a severe clinical picture in humans, ranging from mild malaise to death by sepsis/acute respiratory distress syndrome. 2020-04-09
A family cluster of severe acute respiratory syndrome coronavirus 2 infections. Clinical and epidemiological knowledge of 2019 novel coronavirus disease (COVID-19) is limited. […] This family comprised three laboratory confirmed cases with clinical symptoms. 2020-04-09
Expert consensus from the Italian Society for Colposcopy and Cervico-Vaginal Pathology (SICPCV) for colposcopy and outpatient surgery of the lower genital tract during the COVID-19 pandemic. In the context of the COVID-19 pandemic, patients need to be evaluated within 2-4 weeks in the following cases: cytology result of “squamous cell carcinoma,” “atypical glandular cells, favor neoplastic,” “endocervical adenocarcinoma in situ,” or “adenocarcinoma”; histopathological diagnosis of suspected invasion from cervical/vaginal biopsy, or invasive disease after a cervical excision procedure, vaginal excision, or vulvar biopsy/excision; sudden onset of strongly suggestive symptoms for malignancy. 2020-04-09
Radiological findings and clinical characteristics of pregnant women with COVID-19 pneumonia. To study chest CT images and clinical characteristics of COVID-19 pneumonia in pregnant patients to examine any correlation. […] Clinical presentations were collected retrospectively from records, including laboratory testing, chest CT imaging, and symptoms. […] Descriptive analysis and correlation of patients’ clinical and CT characteristics were performed. […] Radiological findings and clinical characteristics in pregnant women with COVID-19 were similar to those of non-pregnant women with COVID-19. 2020-04-09
Does recombinant human Erythropoietin administration in critically ill COVID-19 patients have miraculous therapeutic effects? After 7 days of treatment, he was discharged with miraculous improvement in his symptoms and hemoglobin level. 2020-04-09
Cardiac and arrhythmic complications in patients with COVID-19. Although coronavirus disease (COVID-19) clinical manifestations are mainly respiratory, major cardiac complications are being reported. 2020-04-13
Impact of Coronavirus (COVID-19) on Otolaryngologic Surgery: A Brief Commentary. Recommendations regarding clinical practice during the Severe Acute Respiratory Syndrome (SARS) and Middle East Respiratory Syndrome (MERS) outbreaks were also reviewed. […] Elective procedures should be postponed indefinitely, and clinical practice should be limited to patients with urgent or emergent needs. […] We summarize current best-practice recommendations for Otolaryngologists to ensure safety for themselves, their clinical staff, and their patients. 2020-04-09
COVID-19 pandemic: Effects and evidence-based recommendations for otolaryngology and head and neck surgery practice. A large number of patients do not have overt signs and symptoms (fever/respiratory), yet pose a real risk to surgeons (who should know this fact and must therefore apply respiratory protective strategies for all patients they encounter). […] Health workers who are: pregnant, over 55 to 65 years of age, with a history of chronic diseases (uncontrolled hypertension, diabetes mellitus, chronic obstructive pulmonary diseases, and all clinical scenarios where immunosuppression is feasible, including that induced to treat chronic inflammatory conditions and organ transplants) should avoid the clinical attention of a potentially infected patient. […] For those who are working with COVID-19 infected patients’ isolation is compulsory in the following settings: (a) unprotected close contact with COVID-19 pneumonia patients; (b) onset of fever, cough, shortness of breath, and other symptoms (gastrointestinal complaints, anosmia, and dysgeusia have been reported in a minority of cases). 2020-04-15
Clinical characteristics of a case series of children with coronavirus disease 2019. We reported the clinical characteristics of a case series of 10 patients with coronavirus disease 2019 (COVID-19) aged from 1 year to 18 years. […] Fever (4 [40.0%]) and cough (3 [30.0%]) were the most common symptoms. […] Our study indicated that COVID-19 children present less severe symptoms and have better outcomes. 2020-04-09
[Analysis of baseline liver biochemical parameters in 324 cases with novel coronavirus pneumonia in Shanghai area]. Objective: To summarize the clinical characteristics and liver biochemical parameters of 324 cases admitted with novel coronavirus pneumonia in Shanghai area. Methods: Clinical data and baseline liver biochemical parameters of 324 cases with novel coronavirus pneumonia admitted to the Shanghai Public Health Clinical Center from January 20, 2020 to February 24, 2020 were retrospectively analyzed. […] The differences in clinical data and baseline liver biochemical parameters of the two groups were described and compared. 2020-04-09
Stand Together and Deliver: Challenges and Opportunities for Rheumatology Education During the COVID19 Pandemic. In a matter of weeks, the COVID19 crisis has totally upended clinical medicine and the practice of rheumatology. 2020-04-09
[Covid-19 diagnosis : clinical recommendations and performance of nasopharyngeal swab-PCR]. This finding suggests the need for strict auto-isolation of patients until the resolution of their symptoms. […] For patients that present with typical symptoms, who have a presumed Covid-19 prevalence of -40-50 %, a negative test should be interpreted with caution and a repeat test may be needed. 2020-04-13
Traumatic stress in the age of COVID-19: A call to close critical gaps and adapt to new realities. However, we propose that these efforts may be limited, in part, by ongoing gaps that exist within our research and clinical care. […] In particular, we suggest that COVID-19 requires us to prioritize and mobilize as a research and clinical community around several key areas: (a) diagnostics, (b) prevention, (c) public outreach and communication, (d) working with medical staff and mainstreaming into nonmental health services, and (e) COVID-19-specific trauma research. 2020-04-14
Survey of COVID-19 Disease Among Orthopaedic Surgeons in Wuhan, People’s Republic of China. A self-administered questionnaire was distributed to collect information such as social demographic variables, clinical manifestations, exposure history, awareness of the outbreak, infection control training provided by hospitals, and individual protection practices. […] The onset of symptoms was from January 13 to February 5, 2020, and peaked on January 23, 8 days prior to the peak of the public epidemic. 2020-04-09
Prediction for Progression Risk in Patients with COVID-19 Pneumonia: the CALL Score. All the consecutive patients with COVID-19 admitted to Fuyang second people’s hospital or the fifth medical center of Chinese PLA general hospital between January 20 and February 22, 2020, were enrolled and their clinical data were retrospectively collected. 2020-04-09
Utilizing integrating network pharmacological approaches to investigate the potential mechanism of Ma Xing Shi Gan Decoction in treating COVID-19. Employing combined therapy of modern medicine and traditional Chinese medicine has been proposed, in which Ma Xing Shi Gan Decoction (MXSGD) was recommended as a basic prescription and applied widely in the clinical treatment of COVID-19. 2020-04-15
Clinical efficacy of lopinavir/ritonavir in the treatment of Coronavirus disease 2019. In view of these conclusions, we suggested that the use of LPV/r combined with pneumonia-associated adjuvant drugs in the clinical treatment for patients with COVID-19 should be promoted. 2020-04-15
Clinical characteristics of 161 cases of corona virus disease 2019 (COVID-19) in Changsha. The purpose of this study was to investigate the clinical features of coronavirus disease 2019 (COVID-19). 2020-04-15
Coronavirus disease 2019: a bibliometric analysis and review. 68 (37.2%) epidemiology, 49 (26.8%) virology and 26 (14.2%) clinical features. 2020-04-15
A primer on viral-associated olfactory loss in the era of COVID-19. In most cases, these episodes of smell loss are self-limiting and coincide with resolution of URI symptoms. 2020-04-09
Co-infection of Coronavirus Disease 2019 and Influenza A: A Report from Iran. We present four patients in this study, selected from among patients who presented with pneumonia symptoms and were suspicious for COVID-19. 2020-04-14
Epidemiology and Clinical Characteristics of COVID-19. The development of highly sensitive RT-PCR has facilitated epidemiological studies that provide insight into the prevalence, seasonality, clinical manifestations and course of COVID-19 infection. 2020-04-14
Improved Early Recognition of Coronavirus Disease-2019 (COVID-19): Single-Center Data from a Shanghai Screening Hospital. To explain the epidemiological characteristics, clinical features, imaging manifestations and to judge diagnostic value of COVID-19 by analyzing the clinical data of COVID-19 suspected and confirmed patients in a non-outbreak, Shanghai, China. […] To clarify the early epidemiology and clinical characteristics about COVID-19. […] Epidemiology, demography, clinical, laboratory and chest CTs were collected and analyzed. […] No significant differences were found in clinical symptoms including fever, cough, dyspnea, sore throat, and fatigue (P > 0.05). […] The early clinical manifestations and imaging findings of COVID-19 are not characteristic in non-outbreak areas. 2020-04-14
The Distance Teaching Practice of Combined Mode of Massive Open Online Course Micro-Video for Interns in Emergency Department During the COVID-19 Epidemic Period. At the time of the COVID-19 outbreak in Wuhan, they were divided into two groups: (1) the experimental group (combined mode of MOOC micro-video) and (2) the control group (traditional theory teaching combined with clinical practice teaching). 2020-04-09
Presymptomatic Transmission of SARS-CoV-2 - Singapore, January 23-March 16, 2020. Clinical and epidemiologic findings of all COVID-19 cases in Singapore through March 16 were reviewed to determine whether presymptomatic transmission might have occurred. […] Presymptomatic transmission was defined as the transmission of SARS-CoV-2 from an infected person (source patient) to a secondary patient before the source patient developed symptoms, as ascertained by exposure and symptom onset dates, with no evidence that the secondary patient had been exposed to anyone else with COVID-19. 2020-04-10
Rapid Sentinel Surveillance for COVID-19 - Santa Clara County, California, March 2020. At the time the investigation began, testing guidance recommended focusing on persons with clinical findings of lower respiratory illness and travel to an affected area or an epidemiologic link to a laboratory-confirmed COVID-19 case, or on persons hospitalized for severe respiratory disease and no alternative diagnosis (1). […] For this investigation, county residents evaluated for respiratory symptoms (e.g., fever, cough, or shortness of breath) who had no known risk for COVID-19 were identified at participating urgent care centers. 2020-04-10
Detection of SARS-CoV-2 Among Residents and Staff Members of an Independent and Assisted Living Community for Older Adults - Seattle, Washington, 2020. On March 10, all residents and staff members at facility 1 were tested for SARS-CoV-2, the virus that causes COVID-19, and asked to complete a questionnaire about their symptoms; all residents were tested again 7 days later. […] The three residents had no symptoms at the time of testing, although one reported an earlier cough that had resolved. 2020-04-10
Coronavirus Disease 2019 in Children - United States, February 12-April 2, 2020. Data from China suggest that pediatric COVID-19 cases might be less severe than cases in adults and that children might experience different symptoms than do adults (4,5); however, disease characteristics among pediatric patients in the United States have not been described. […] Data were available for a small proportion of patients on many important variables, including symptoms (9.4%), underlying conditions (13%), and hospitalization status (33%). […] Among those with available information, 73% of pediatric patients had symptoms of fever, cough, or shortness of breath compared with 93% of adults aged 18-64 years during the same period; 5.7% of all pediatric patients, or 20% of those for whom hospitalization status was known, were hospitalized, lower than the percentages hospitalized among all adults aged 18-64 years (10%) or those with known hospitalization status (33%). […] Social distancing and everyday preventive behaviors remain important for all age groups as patients with less serious illness and those without symptoms likely play an important role in disease transmission (6,7). 2020-04-10
Awareness, Attitudes, and Actions Related to COVID-19 Among Adults With Chronic Conditions at the Onset of the U.S. Outbreak: A Cross-sectional Survey. Cross-sectional survey linked to 3 active clinical trials and 1 cohort study. 5 academic internal medicine practices and 2 federally qualified health centers. 630 adults aged 23 to 88 years living with 1 or more chronic conditions. […] Nearly a third could not correctly identify symptoms (28.3%) or ways to prevent infection (30.2%). 2020-04-14
Delivery in pregnant women infected with SARS-CoV-2: A fast review. Few case reports and clinical series exist on pregnant women infected with SARS-CoV-2 who delivered. […] The following was extracted: author; country; number of women; study design; gestational age at delivery; selected clinical maternal data; mode of delivery; selected neonatal outcomes. 2020-04-09
High prevalence of obesity in severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) requiring invasive mechanical ventilation. In this retrospective cohort study we analyzed the relationship between clinical characteristics, including body mass index (BMI), and the requirement for invasive mechanical ventilation (IMV) in 124 consecutive patients admitted in intensive care for SARS-CoV-2, in a single French center. 2020-04-10
Intensive care management of coronavirus disease 2019 (COVID-19): challenges and recommendations. Streamlining of workflows for rapid diagnosis and isolation, clinical management, and infection prevention will matter not only to patients with COVID-19, but also to health-care workers and other patients who are at risk from nosocomial transmission. 2020-04-09
Coronavirus membrane fusion mechanism offers as a potential target for antiviral development. We also provide a supplemental file containing background information on the biology, epidemiology, and clinical features of all human-infecting coronaviruses, along with a phylogenetic tree of these coronaviruses. 2020-04-09
High-resolution Chest CT Features and Clinical Characteristics of Patients Infected with COVID-19 in Jiangsu, China. Detailed clinical data, chest HRCT basic performances and certain signs were recorded, and ground-glass opacity (GGO), consolidation, fibrosis and air trapping were quantified. […] Both clinical types and CT stages were evaluated. […] Fever and cough were main symptoms. […] Clinical performances of patients with COVID-19, mostly with epidemiologic history and typical symptoms, were critical valuable in the diagnosis of the COVID-19. 2020-04-11
Mental Health and Psychosocial Problems of Medical Health Workers during the COVID-19 Epidemic in China. 0.4%; p < 0.01), and obsessive-compulsive symptoms (5.3 vs. […] They also had higher total scores of ISI, GAD-2, PHQ-2, and SCL-90-R obsessive-compulsive symptoms (p ≤ 0.01). […] Among medical health workers, having organic disease was an independent factor for insomnia, anxiety, depression, somatization, and obsessive-compulsive symptoms (p < 0.05 or 0.01). […] Living in rural areas, being female, and being at risk of contact with COVID-19 patients were the most common risk factors for insomnia, anxiety, obsessive-compulsive symptoms, and depression (p < 0.01 or 0.05). […] Among nonmedical health workers, having organic disease was a risk factor for insomnia, depression, and obsessive-compulsive symptoms (p < 0.01 or 0.05). 2020-04-09
Structure of Mpro from COVID-19 virus and discovery of its inhibitors. In order to rapidly discover lead compounds for clinical use, we initiated a program of combined structure-assisted drug design, virtual drug screening and high-throughput screening to identify new drug leads that target the COVID-19 virus main protease (Mpro). […] Next, through a combination of structure-based virtual and high-throughput screening, we assayed over 10,000 compounds including approved drugs, drug candidates in clinical trials, and other pharmacologically active compounds as inhibitors of Mpro. […] Our results demonstrate the efficacy of this screening strategy, which can lead to the rapid discovery of drug leads with clinical potential in response to new infectious diseases for which no specific drugs or vaccines are available. 2020-04-09
Role of Tissue Engineering in COVID-19 and Future Viral Outbreaks. Tissue engineering has the potential for critical impact on clinical outcomes in viral outbreaks. 2020-04-15
Coronavirus Disease 19 (COVID-19): Implications for Clinical Dental Care. Thus, the aim of this article is to provide a brief overview of the epidemiology, symptoms, and routes of transmission of this novel infection. 2020-04-14
The COVID-19 pandemic: Important considerations for contact lens practitioners. Where the availability of local clinical care is restricted, practitioners could consider advising patients to reduce or eliminate sleeping in their CL (where patients have the appropriate knowledge about correct daily care and access to suitable lens-care products) or consider the option of moving patients to daily disposable lenses (where patients have appropriate lens supplies available). […] Patients should also avoid touching their face, including their eyes, nose and mouth, with unwashed hands and avoid CL wear altogether if unwell (particularly with any cold or flu-like symptoms). 2020-04-13
Hospital pharmacists’ pharmaceutical care for hospitalized patients with COVID-19: Recommendations and guidance from clinical experience. Based on the method of evidence-based pharmacy, clinical evidence of therapeutical drugs for COVID-19 were retrieved and summarized. […] Based on clinical experience Chinese hospital pharmacists gained from providing pharmaceutical care services during COVID-19 pandemic, taking COVID-19 hospitalized patients’ needs into consideration, the methods and strategies hospital pharmacists shall use to provide pharmaceutical care were analyzed and summarized. 2020-04-13
Coronavirus Disease (COVID-19) in Children - What We Know So Far and What We Do Not? Clinical features of COVID-19 in children include fever and cough, but a large proportion of infected children appears to be asymptomatic and may contribute to transmission. 2020-04-10
Characteristics and Mechanism of Liver Injury in 2019 Coronavirus Disease. The clinical features and outcomes of Chinese patients with COVID-19 have been widely reported. […] The clinical, pathological and laboratory characteristics as well as underlying pathophysiology and etiology of liver injury in COVID-19 remain largely unclear. 2020-04-13
COVID-19 and Liver Dysfunction: Current Insights and Emergent Therapeutic Strategies. Based on the current evidence from case reports and case series, this review article focuses on the demographic and clinical characteristics, potential mechanisms, and treatment options for COVID-19-related liver dysfunction. 2020-04-13
SARS-CoV-2 and COVID-19 in older adults: what we may expect regarding pathogenesis, immune responses, and outcomes. Here, we briefly review the virus, its structure and evolution, epidemiology and pathogenesis, immunogenicity and immune, and clinical response in older adults, using available knowledge on SARS-CoV-2 and its highly pathogenic relatives MERS-CoV and SARS-CoV-1. […] We conclude by discussing clinical and basic science approaches to protect older adults against this disease. 2020-04-10
Operating Room Guide for Confirmed or Suspected COVID-19 Pregnant Patients Requiring Cesarean Delivery. We sought to provide a clinical practice protocol for our labor and delivery (L&D) unit, to care for confirmed or suspected COVID-19 patients requiring cesarean delivery. 2020-04-10
[SARS CoV-2/COVID-19: Evidence-Based Recommendation on Diagnosis and Therapy]. In about 20% of patients, severe symptoms occur after a mean incubation period of 5 - 6 days; 5% of patients need intensive care therapy. 2020-04-13
[Obstetric Anesthesia During the SARS-CoV-2 Pandemic - a Brief Overview of Published Recommendations for Action by National and International Specialist Societies and Committees]. In the meantime, the clinical course and outcome of some COVID-19 patients with an existing pregnancy or peripartum courses have been reported. 2020-04-13
[COVID-19 Crisis: Early Observations on a Pandemic’s Psychiatric Problems]. We have recently observed several clusters of psychiatric symptoms in the context of COVID-19: (1) increased anxiety in psychiatric in- and outpatients with different diagnoses; (2) more cases of domestic violence often associated with increased drug- or alcohol-consumption in offenders and victims; (3) a nihilistic “apocalyptic” syndrome of elderly patients cut-off from their families; (4) visual and acoustic hallucinoses due to pneumonia and sepsis-related confusional states. 2020-04-10
Slowdown of urology residents’ learning curve during COVID-19 emergency. The urology residents do not have the opportunity to carry out clinical activities nor to be tutored, as the senior physicians are engaged in the emergency’s management. 2020-04-10
The clinical feature of silent infections of novel coronavirus infection (COVID-19) in Wenzhou. Here were reported clinical features of silent infected COVID-19 patients. 2020-04-10
Handling and Processing of Blood Specimens from Patients with COVID-19 for Safe Studies on Cell Phenotype and Cytokine Storm. Working in a clinical laboratory is posing several safety challenges. 2020-04-13
[Roles of multidisciplinary team (MDT) in diagnosis and treatment of suspected cases of corona virus disease 2019 (COVID-19)]. The clinical data of 48 patients with suspected COVID-19 admitted in Jinhua Central Hospital from January 21, 2020 to March 20, 2020 were retrospectively analyzed. 2020-04-13
Clinical manifestation, diagnosis, prevention and control of SARS-CoV-2 (COVID-19) during the outbreak period. The novel coronavirus SARS-CoV-2 (Covid-19), spreading from Wuhan, China, is one of the causes of respiratory infections that can spread to other people through respiratory particles, and can cause symptoms such as fever, dry cough, shortness of breath, anorexia, fatigue and sore throat in infected patients. 2020-04-15
Exploring the genetics, ecology of SARS-COV-2 and climatic factors as possible control strategies against COVID-19 Early available clinical data have indicated that geriatric persons cum those with comorbidity such as cardiovascular, metabolic and immunological disorders suffered severe form of COVID-19. 2020-04-15
SARS-CoV-2, SARS-CoV, and MERS-COV: A comparative overview So, this review aims at understanding the new scenario of SARS-CoV-2 outbreak and compares the epidemiology, clinical presentations, and the genetics of these coronaviruses. 2020-04-15
Neurologic Manifestations of Hospitalized Patients With Coronavirus Disease 2019 in Wuhan, China. Several studies have described typical clinical manifestations including fever, cough, diarrhea, and fatigue. […] Clinical data were extracted from electronic medical records, and data of all neurologic symptoms were checked by 2 trained neurologists. […] Compared with patients with nonsevere infection, patients with severe infection were older, had more underlying disorders, especially hypertension, and showed fewer typical symptoms of COVID-19, such as fever and cough. 2020-04-14
Myocardial localization of coronavirus in COVID-19 cardiogenic shock. We describe the first case of acute cardiac injury directly linked to myocardial localization of severe acute respiratory syndrome coronavirus (SARS-CoV-2) in a 69-year-old patient with flu-like symptoms rapidly degenerating into respiratory distress, hypotension, and cardiogenic shock. 2020-04-11
COVID-19 with Different Severity: A Multi-center Study of Clinical Features. We compared the clinical characteristics, laboratory examinations, CT images and treatment of COVID-19 patients from three different cities in China. 476 patients were recruited from Jan 1 to Feb 15, 2020 at three hospitals in Wuhan, Shanghai and Anhui. 2020-04-10
ILROG Emergency Guidelines for Radiation Therapy of Hematological Malignancies During the COVID-19 Pandemic. The emphasis is on maintaining clinical efficacy and safety by increasing the dose per fraction while reducing the number of daily treatments. […] The guidance is informed by adhering to acceptable radiobiological parameters and clinical tolerability. 2020-04-10
Point-of-care lung ultrasound in patients with COVID-19 - a narrative review. This narrative review provides a summary of evidence and clinical guidance for the use and interpretation of lung ultrasound for patients with moderate, severe and critical COVID-19 associated lung injury. […] Mechanisms by which the potential lung ultrasound workforce can be deployed are explored, including a pragmatic approach to training, governance, imaging, interpretation of images and implementation of lung ultrasound into routine clinical practice. 2020-04-10
Telemedicine in Liver Disease and Beyond: Can the COVID-19 Crisis Lead to Action? Evidence strongly supports that access to specialty gastroenterology or hepatology care in cirrhosis is associated with higher adherence to guideline-recommended care and improves clinical outcomes. […] Telemedicine, defined as the delivery of health care services at a distance using electronic means for diagnosis and treatment, holds tremendous promise to increase access to broadly specialty care. 2020-04-10
Global challenges to urology practice during COVID-19 pandemic. The common symptoms include a dry continuous cough, fever and shortness of breath; severe cases involve pneumonia which may require ventilatory support. 2020-04-10
Clinical and ethical challenges for emergency departments during communicable disease outbreaks: can lessons from Ebola Virus Disease be applied to the COVID-19 pandemic? This perspective article draws on qualitative data from a longitudinal, ethnographic study of an Australian tertiary ED to illustrate the clinical and ethical challenges faced by EDs during PHEs. 2020-04-10
Compassionate Use of Remdesivir for Patients with Severe Covid-19. This report is based on data from patients who received remdesivir during the period from January 25, 2020, through March 7, 2020, and have clinical data for at least 1 subsequent day. […] In this cohort of patients hospitalized for severe Covid-19 who were treated with compassionate-use remdesivir, clinical improvement was observed in 36 of 53 patients (68%). 2020-04-10
Type 1 interferons as a potential treatment against COVID-19. Type 1 interferons have a broad antiviral activity in vitro and are currently evaluated in a clinical trial to treat MERS-CoV. […] In this review, we discuss preliminary data concerning the potential activity of type 1 interferons on SARS-CoV-2, and the relevance of evaluating these molecules in clinical trials for the treatment of COVID-19. 2020-04-16
The Role of Chest Imaging in Patient Management during the COVID-19 Pandemic: A Multinational Consensus Statement from the Fleischner Society. Fourteen key questions, corresponding to 11 decision points within the three scenarios and three additional clinical situations, were rated by the panel based upon the anticipated value of the information that thoracic imaging would be expected to provide. 2020-04-16
Symptom Cluster of ICU nurses treating COVID-19 pneumonia patients in Wuhan, China. The present study aims to investigate the symptoms and causes of SSD of ICU nurses treating COVID-19 pneumonia. […] Exploratory factor analysis was performed to cluster the symptoms, and logistic regression analysis to find the risk factors of the symptoms. […] Five major symptoms were chest-discomfort-and-palpitation (31.4%), dyspnea (30.7%), nausea (21.4%), headache (19.3%), and dizziness (17.9%). […] In exploratory factor analysis, the symptoms were classified into three clusters: Cluster A of breathing and sleep disturbances (dizziness, sleepiness, dyspnea); Cluster B of gastrointestinal complaints and pain (nausea, headache), and Cluster C of general symptoms (xerostomia, fatigue, chest-discomfort-and-palpitation). 2020-04-13
Rapid De-Escalation and Triaging Patients in Community-Based Palliative Care. We implement thorough screening for COVID-19 symptoms at multiple levels before a patient is seen by a designated provider. […] We recommend active triaging, communication, frequent screening for COVID-19 symptoms for palliative care patients been evaluated in the community setting. 2020-04-12
Crisis Symptom Management and Patient Communication Protocols Are Important Tools for All Clinicians Responding to COVID-19. Symptom management and skilled communication with patients and families are essential clinical services in the midst of the COVID-19 pandemic. […] It is imperative that all clinicians responding to the COVID-19 crisis have access to clinical tools to support symptom management and difficult patient and family communication. 2020-04-13
Rapid and visual detection of 2019 novel coronavirus (SARS-CoV-2) by a reverse transcription loop-mediated isothermal amplification assay. To describe the availability of this method in clinical diagnosis, we collected 130 specimens from patients with clinically suspected SARS-CoV-2 infection. […] These results demonstrate that we developed a rapid, simple, specific, and sensitive RT-LAMP assay for SARS-CoV-2 detection among clinical samples. 2020-04-13
Individual risk management strategy and potential therapeutic options for the COVID-19 pandemic. Among the virus-contracted hosts, their different metabolic status, as determined by their diet, nutrition, age, sex, medical conditions, lifestyle, and environmental factors, govern the personal fate toward different clinical severity of COVID-19, from asymptomatic, mild, moderate, to death. 2020-04-13
COVID-19 in a patient with long-term use of glucocorticoids: A study of a familial cluster. Here, we report a familial cluster of COVID-19 where a 47-year-old woman with long-term use of glucocorticoids did not develop any symptoms within the 14-day quarantine period but was confirmed with COVID-19 by tested positive of antibody on day 40 after she left Wuhan. 2020-04-16
Psychological status of medical workforce during the COVID-19 pandemic: A cross-sectional study. Furthermore, as compared to the non-clinical staff, front line medical staff with close contact with infected patients, including working in the departments of respiratory, emergency, infectious disease, and ICU, showed higher scores on fear scale, HAMA and HAMD, and they were 1.4 times more likely to feel fear, twice more likely to suffer anxiety and depression. 2020-04-16
Protecting Labor and Delivery Personnel from COVID-19 during the Second Stage of Labor. The novel coronavirus disease 2019 (COVID-19) is spreading fast and is affecting the clinical workers at much higher risk than the general population. 2020-04-10
Development of a Novel, Genome Subtraction-Derived, SARS-CoV-2-Specific COVID-19-nsp2 Real-Time RT-PCR Assay and Its Evaluation Using Clinical Specimens. In a containment-based strategy, rapid, sensitive and specific testing is important in epidemiological control and clinical management. […] Evaluation of the new assay using 59 clinical specimens from 14 confirmed cases showed 100% concordance with our previously developed COVID-19-RdRp/Hel reference assay. 2020-04-13
Prolonged viral shedding in feces of pediatric patients with coronavirus disease 2019. Epidemiological, clinical, laboratory, and radiological characteristics and treatment data were collected. 2020-04-14
Whose life to save? Scarce resources allocation in the COVID-19 outbreak. From an ethical perspective, the novelty of the current emergency is not grounded in the devastating effects of scarce resources allocation, which is rife in recent and present clinical practice. 2020-04-11
Dentistry and coronavirus (COVID-19) - moral decision-making. Major and rapid reorganisation of both clinical and support services is not straightforward. 2020-04-15
Managing Cutaneous Immune-Mediated Diseases During the COVID-19 Pandemic. Coronavirus disease 2019 (COVID-19) is a clinical syndrome caused by a novel coronavirus called severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). 2020-04-11
Rheumatologists’ perspective on coronavirus disease 19 (COVID-19) and potential therapeutic targets. • Although preliminary results may be encouraging, high-quality clinical trials are needed to better understand the role of drugs commonly used in rheumatology like hydroxychloroquine and tocilizumab in COVID-19. 2020-04-11
Management of COVID-19 in patients after liver transplantation: Beijing working party for liver transplantation. In this article, we reviewed the clinical aspects of 2019-nCoV infection, characteristics of liver transplant recipients, immunosuppressant usage, and potential drug interactions to provide recommendations to clinical staff managing liver transplant recipients during the COVID-19 epidemic. 2020-04-11
First case of COVID-19 complicated with fulminant myocarditis: a case report and insights. A 63-year-old male was admitted with pneumonia and cardiac symptoms. 2020-04-11
Novel Coronavirus (SARS-CoV-2) Infection in A Renal Transplant Recipient: Case Report. The clinical course of patients remains to be fully characterized, clinical presentation ranges from asymptomatic infection to acute respiratory distress syndrome and acute renal failure,no pharmacological therapies of proven efficacy yet exist. […] Further data are needed to achieve better understanding of the impact of immunosuppressive therapy on the clinical presentation, severity and outcome of SARS-CoV-2 infections in solid organ transplant recipients. 2020-04-11
Fatal outcome in a liver transplant recipient with COVID-19. Liver injury is common in patients with COVID-19, but little is known about its clinical presentation and severity in the context of liver transplantation. […] The patient came to clinic with symptoms of respiratory disease; pharyngeal swabs for severe acute respiratory syndrome coronavirus 2 were positive. 2020-04-11
Presentation of new onset anosmia during the COVID-19 pandemic. In patients who reported other symptoms, 51% reported either cough or fever and therefore met current guidelines for self-isolation. […] Anosmia is reported in conjunction with well-reported symptoms of coronas virus, but 1 in 6 patients with recent onset anosmia report this as an isolated symptom. 2020-04-11
Cluster of coronavirus disease 2019 (Covid-19) in the French Alps, 2020. Finally, the dissociation between upper and lower respiratory tract results underscores the need for close monitoring of the clinical evolution of suspect Covid-19 cases. 2020-04-11
Practical Guidance for Managing EMG Requests and Testing during the COVID-19 Pandemic. Clinical care must be provided to help our patients in a timely manner, while keeping them, health care personnel and the community safe. […] However, each referral must be reviewed on a case-by-case basis, and the clinical situation will evolve over time, necessitating flexibility in managing EDX triaging. 2020-04-11
Benign COVID-19 in an immunocompromised cancer patient -  the case of a married couple. The clinical course of the immunocompromised partner was benign, without need of intensive care. 2020-04-16
SAA is a biomarker to distinguish the severity and prognosis of Coronavirus Disease 2019 (COVID-19). All patients completed at least twice laboratory data collection and clinical condition assessment at three time points indicated for this study; The length of hospital stay was longer than 14 days prior to February 26, 2020. 2020-04-14
Diarrhea during COVID-19 infection: pathogenesis, epidemiology, prevention and management. Here we investigate the epidemiology, clinical presentation, molecular mechanisms, management, and prevention of SARS-CoV-2 associated diarrhea. […] Clinical studies show an incidence rate of diarrhea ranging from 2% to 50% of cases. […] It may precede or trail respiratory symptoms. 2020-04-13
COVID-19: A promising cure for the global panic. Here, we have discussed the structure of virus; varying symptoms among COVID-19, SARS, MERS and common flu; the probable mechanism behind the infection and its immune response. 2020-04-16
SARS-Cov-2 in Spanish Intensive Care: Early Experience with 15-day Survival In Vitoria. Symptoms began a median of 7 [5-12] days before ICU admission. 2020-04-14
In silico studies on therapeutic agents for COVID-19: Drug repurposing approach. In the present study, 61 molecules that are already being used in clinics or under clinical scrutiny as antiviral agents are surveyed via docking study. 2020-04-12
The Restructuring of Structural Heart Disease Practice During The Covid-19 Pandemic. In the midst of a global pandemic of a novel infectious disease, reality-based considerations comprise an important starting point for formulating clinical management pathways. 2020-04-12
Medically-Necessary, Time-Sensitive Procedures: A Scoring System to Ethically and Efficiently Manage Resource Scarcity and Provider Risk During the COVID-19 Pandemic. The decision to proceed with Medically-Necessary, Time-Sensitive (MeNTS) procedures in the setting of the COVID-19 pandemic requires incorporation of factors (resource limitations, COVID-19 transmission risk to providers and patients) heretofore not overtly considered by surgeons in the already complicated processes of clinical judgment and shared decision-making. 2020-04-16
COVID-19 and diabetes: Knowledge in progress. We searched for articles in PubMed and Google Scholar databases till 02 April 2020, with the following keywords: “SARS-CoV-2”, “COVID-19”, “infection”, “pathogenesis”, “incubation period”, “transmission”, “clinical features”, “diagnosis”, “treatment”, “diabetes”, with interposition of the Boolean operator “AND”. […] The clinical spectrum of COVID-19 is heterogeneous, ranging from mild flu-like symptoms to acute respiratory distress syndrome, multiple organ failure and death. […] Further research regarding this relationship and its clinical management is warranted. 2020-04-16
Fighting against COVID-19: Innovative strategies for clinical pharmacists. Clinical pharmacists’ routine task is carrying out pharmaceutical care to ensure patients’ safe and reasonable medication use. […] However, under public health emergencies, such as the outbreak of COVID-19, the work strategies of clinical pharmacists need to be modified according to the rapid spread of the disease, where information and resources are usually lack to guide them. […] To retrieve and investigate the prevention and control measures of clinical pharmacists during the outbreak of novel coronavirus, summarize the roles and responsibilities of clinical pharmacists, and to propose innovative strategies for developing pharmacy services under the epidemic. […] The Chinese and English databases, self-media network, website of professional society or medical institution, and clinical trial center platforms were searched, and clinical pharmacists involved in the work against COVID-19 were surveyed and interviewed. […] Clinical pharmacists play a vital role in leading the industry to formulate work instructions, provide frontline medical staff with drug information, and develop innovative pharmacy services to promote the rational use of medicines with collaborative teamwork and close communication according to the epidemic situation of COVID-19. […] Facing public health emergencies, clinical pharmacists can give full play to their professional expertise, analyze the current situation rationally, formulate telehealth strategies swiftly, and work in a united and efficient manner to provide innovative pharmacy services to ensure medication safety and rational use of medicine. 2020-04-12
Health-Related-Quality of Life in Common Variable Immunodeficiency Italian patients switched to remote assistance during the COVID-19 pandemic. The risk of anxiety/depression is associated to SARS-CoV-2 pandemia and to patients’ fragility, and not to related clinical conditions associated with Common Variable Immune Deficiencies. 2020-04-12
Clinical characteristics and outcomes of older patients with coronavirus disease 2019 (COVID-19) in Wuhan, China (2019): a single-centered, retrospective study. In this study, we aimed to describe the clinical course and outcomes of older patients with COVID-19. […] Common symptoms of older patients with COVID-19 included fever (94.5%; n=52), dry cough (69.1%; n=38), and chest distress (63.6%; n=35). […] In the recent outbreak of COVID-19, our local hospital in Wuhan found that patients aged 65 and older had greater initial comorbidities, more severe symptoms, and were more likely to experience multi-organ involvement and death, as compared with younger patients. 2020-04-12
CT features of SARS-CoV-2 pneumonia according to clinical presentation: a retrospective analysis of 120 consecutive patients from Wuhan city. To characterize the chest computed tomography (CT) findings of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) according to clinical severity. […] This was a retrospective analysis of the clinical and thoracic CT features of 120 consecutive patients with confirmed SARS-CoV-2 pneumonia admitted to a tertiary university hospital between January 10 and February 10, 2020, in Wuhan city, China. […] The clinical and CT features at admission may enable clinicians to promptly evaluate the prognosis of patients with SARS-CoV-2 pneumonia. […] • The clinical features and predominant patterns of abnormalities on CT for asymptomatic, typic common, and severe cases were summarized. 2020-04-12
Should Institutions Disclose the Names of Employees with Covid-19? Further, this individual’s local health department has a protocol for identifying people who have been in direct contact with anyone testing positive for Covid-19 (such as this Prestigious University staff member) so that they can self-quarantine and watch for COVID-19 symptoms for a period of 14 days from their last contact with the infected individual. 2020-04-12
Threatening drug-drug interaction in a kidney transplant patient with Coronavirus Disease 2019 (COVID-19). For this reason, clinical manifestations may differ from general population and different treatment approaches may be needed. […] Initial symptoms were fatigue, dry cough and coryza; she never had fever nor oxygen supplementation. […] The peculiarity of clinical presentation and the management difficulties represent the flagship of our case-report. 2020-04-12
Association of chemosensory dysfunction and Covid-19 in patients presenting with influenza-like symptoms. Rapid spread of the SARS-CoV-2 virus and concern for viral transmission by ambulatory patients with minimal to no symptoms underline the importance of identifying early or subclinical symptoms of Covid-19 infection. […] Two such candidate symptoms include anecdotally reported loss of smell and taste. […] A single-institution, cross-sectional study evaluating patient-reported symptoms with a focus on smell and taste was conducted using an internet-based platform on adult subjects who underwent testing for Covid-19. […] Logistic regression was employed to identify symptoms associated with Covid-19 positivity. […] A total of 1480 patients with influenza-like symptoms underwent Covid-19 testing between March 3 through 29, 2020. […] Of patients who reported Covid-19-associated loss of smell, 74% (28/38) reported resolution of anosmia with clinical resolution of illness. […] In ambulatory individuals with influenza-like symptoms, chemosensory dysfunction was strongly associated with Covid-19 infection and should be considered when screening symptoms. […] Most will recover chemosensory function within weeks paralleling resolution of other disease-related symptoms. 2020-04-12
Anesthesia Management and Perioperative Infection Control in Patients With the Novel Coronavirus. The authors have presented a protocolized approach that uses diagnostic criteria to clearly define benchmarks from the medical history along with clinical symptoms and laboratory tests. 2020-04-16
Early nutritional supplementation in non-critically ill patients hospitalized for the 2019 novel coronavirus disease (COVID-19): Rationale and feasibility of a shared pragmatic protocol. However, to cope with the current emergency crisis, its aim is to promptly and pragmatically implement nutritional care in patients with COVID-19, which might be overlooked despite being potentially beneficial to clinical outcomes and effective in preventing the consequences of malnutrition in this patient population. 2020-04-13
Clinical and computed tomographic (CT) images characteristics in the patients with COVID-19 infection: What should radiologists need to know? To evaluate the clinical and computed tomographic (CT) features in the patients with COVID-19 pneumonia confirmed by the real-time reverse transcriptase polymerase chain reaction (rRT-PCR) amplification of the viral DNA from a sputum sample. […] Clinical information and CT findings of a total of 14 patients with COVID-19 infection (age range, 12-83 years; females 6) were analyzed retrospectively. […] The clinical information includes the history of exposure, laboratory results, and the symptoms (such as fever, cough, headache, etc.) […] Seven patients had fever, 7 had cough, 2 had headache, 3 had fatigue, 1 had body soreness, 3 had diarrhea, and 2 had no obvious symptoms. […] The radiologists should know these CT findings and clinical information, which could help for accurate analysis in the patients with 2019 novel coronavirus infection. 2020-04-13
Home and Community-Based Physical Therapist Management of Adults With Post-Intensive Care Syndrome. This article reports the prevalence and clinical presentation of PICS and provides recommendations for physical examination and outcomes measures, plan of care, and intervention strategies. 2020-04-13
Mesenchymal Stem Cell Therapy for COVID-19: Present or Future. In this regard, mesenchymal stem cells (MSCs)-based immunomodulation treatment has been proposed as a suitable therapeutic approach and several clinical trials have begun. […] Recently, MSCs according to their immunomodulatory and regenerative properties attract attention in clinical trials. […] Given the uncertainties in this area, we reviewed reported clinical trials and hypotheses to provide useful information to researchers and those interested in stem cell therapy. […] However, currently, there are no approved MSC-based approaches for the prevention and/or treatment of COVID-19 patients but clinical trials ongoing. 2020-04-13
Delayed Initiation of Remdesivir in a COVID-19 Positive Patient. A previously healthy 40 year-old male was admitted to the hospital three days after the onset of coronavirus disease 2019 (COVID-19) symptoms, including dry cough, fever, and shortness of breath progressing to intubation and increased mechanical ventilator support. 2020-04-13
A systematic review of the prophylactic role of chloroquine and hydroxychloroquine in Coronavirus Disease-19 (COVID-19). PubMed, EMBASE,, ICTRP, and Cochrane Library databases were searched for studies that evaluated the prophylactic role of CQ or HCQ on SARS-CoV-2 (pre-clinical studies) or COVID-19 (clinical studies) until 30 March 2020. […] A total of 45 articles were screened and five (three in vitro pre-clinical studies and two clinical opinions) were included. […] The pre-clinical studies showed the prophylactic effects of CQ and HCQ against SARS-CoV-2. […] On the other hand, the clinical opinions advocated the prophylactic use of CQ and HCQ against COVID-19. […] However, no original clinical studies on the prophylactic role of CQ or HCQ on COVID-19 were available. […] Although pre-clinical results are promising, till date, there is dearth of evidence to support the efficacy of CQ or HCQ in preventing COVID-19. 2020-04-13
Performance of Electrophysiology Procedures at an Academic Medical Center Amidst the 2020 Coronavirus (COVID-19) Pandemic. In this proposal, we detail the specific protocol changes that our EP department has adopted during the COVID-19 pandemic, including performance of only urgent/emergent procedures, afterhours/7-day per week laboratory operation, single attending-only cases to preserve PPE, appropriate use of PPE, telemedicine and video chat follow-up appointments, and daily conferences to collectively manage the clinical and ethical dilemmas to come. 2020-04-13
Containing COVID-19 in the emergency room: the role of improved case detection and segregation of suspect cases. Frontline physicians need to be given leeway to decide on the disposition of cases based on clinical suspicion during an ongoing outbreak of COVID-19. 2020-04-13
G6PD and chloroquine: selecting the treatment against SARS-CoV-2? HCov-229E is one of the four flu-causing coronaviruses which share great sequence similitude, while many symptoms of patients infected with COVID-19 resemble those of patients infected with these known flu-causing coronaviruses.2 A previous study reported that human lung epithelial A549 cells treated with glucose 6-phosphate dehydrogenase (G6PD) interfering RNA (RNAi) to lower G6PD activity displayed augmented (12-fold) viral production in comparison to normal counterparts when infected with coronavirus HCov-229E. 2020-04-13
[Rapid establishment of traditional Chinese medicine prevention and treatment of 2019-nCoV based on clinical experience and molecular docking]. Taking full advantage of the clinical experience of traditional Chinese medicine(TCM) in preventing and controlling major epidemics such as SARS, it is an important mission for TCM to propose effective formula with immediate response and solid evidence by using modern biomedical knowledge and techniques(molecular docking assisted TCM formulation for short). […] In view of the high homology between the gene sequences of the novel coronavirus and SARS virus, and the similarities between the two in terms of pathogenic mechanism and clinical manifestations, our team established a rapid screening and optimization model for the prevention and treatment of the novel coronavirus based on clinical experience and molecular docking technology. […] Firstly, the clinical team and the research team pre-developed and screened TCM formula by using &quot;back-to-back&quot; manner. […] The result was largely consistent with the formula raised by the clinical group, verifying and supporting its rationality. […] This provides evidence for the scientific and potential efficacy of the TCM prescription from the perspective of treatment target analysis, and also suggests that the TCM prescription has the potential to directly inhibit viral infection in addition to improving clinical symptoms or syndromes. […] Based on this, our team optimized and formed a new anti-coronavirus TCM prescription &quot;Keguan Yihao&quot;, immediately providing the TCM prescription with certain clinical experience and objective evidence support for the prevention and treatment of new emergent infectious diseases in our hospital. […] The TCM prescription was combined with modern medicine symptomatic supportive treatment for clinical treatment, preliminary results showed better effect than symptomatic supportive therapy alone. […] This research has innovated the method mode in clinical practice and basic research integration of traditional Chinese medicine for the prevention and control of new emerging infectious diseases. 2020-04-14
[Study on treatment of “cytokine storm” by anti-2019-nCoV prescriptions based on arachidonic acid metabolic pathway]. This study intends to provide reference for clinical use of traditional Chinese medicine to resist new coronavirus. 2020-04-14
[Analysis on clinical study protocols of traditional Chinese medicine for coronavirus disease 2019]. To analyze the registered clinical trial protocols of traditional Chinese medicine(TCM) for the prevention and treatment of coronavirus disease 2019(COVID-19), in order to provide information for improving the quality of research design. […] The website of the Chinese Clinical Trial Registry( and the American Clinical Trial Registry( were searched to collect protocols of TCM for COVID-19. […] A total of 49 clinical trial protocols of TCM for COVID-19 were included. […] The primary evaluation outcomes mainly included antipyretic time, clinical symptom relief, novel coronavirus nucleic acid turning to negative, conversion rate of severe cases and chest CT. […] There was a quick response of clinical research on the prevention and treatment of COVID-19 with TCM, with the current registered protocols covers the whole process of disease prevention, treatment and rehabilitation. 2020-04-14
[Analysis on pattern of prescriptions and syndromes of traditional Chinese medicine for prevention and treatment of COVID-19]. To investigate the regularity of prescription and clinical syndromes by analyzing the diagnosis and treatment protocols of traditional Chinese medicine(TCM) for coronavirus disease 2019(COVID-19), so as to provide references for syndrome differentiation and relevant researches. 2020-04-14
[Analysis of property and efficacy of traditional Chinese medicine in staging revention and treatment of coronavirus disease 2019]. Staged medication and local conditions need attention during the identification and treatment of COVID-19 clinical syndromes. 2020-04-14
[Strategy of pharmaceutical care services for clinical Chinese pharmacists in coronavirus disease 2019 (COVID-19)]. This article will introduce the TCM cognition of the COVID-19, analyze the clinical application of Chinese medicine and the entry point of pharmaceutical care, and clarify that clinical Chinese pharmacists can participate in making medication therapy plan, medication reconciliation, and prescription review, promoting rational drug use, pharmaceutical monitoring, and drug risk management. […] The participation of clinical Chinese pharmacists in the prevention and treatment of COVID-19 is conducive to improving the level of rational use of TCM, by ensuring the effectiveness, and safety. 2020-04-14
[Research progress of intervention of Chinese herbal medicine and its active components on human coronavirus]. The advantages of traditional Chinese medicine(TCM) in treating SARS and MERS are that it can intervene and block the progression of disease in early stage, significantly reduce symptoms, shorten the treatment duration of patients, reduce complications and side effects caused by hormone therapy. […] Chinese patent medicines and prescriptions in medical observation and clinical treatment were recommended in the &quot;pneumonia diagnosis and treatment plan for new coronavirus infection&quot;(trial version fifth) of the National Health Commission of the People’s Republic of China. […] TCM shows good clinical efficacy and great potential in the treatment of COVID-19. […] In this paper, we reviewed traditional Chinese medicines and its active ingredients in the hope of bringing novel inspirations to the drug screening and clinical treatment for COVID-19. 2020-04-14
Update on use of chloroquine/hydroxychloroquine to treat coronavirus disease 2019 (COVID-19). Increasing evidence obtained from completed clinical studies indicates the prospects for chloroquine/hydroxychloroquine to treat COVID-19. […] More randomized control clinical studies are warranted to determine the feasibility of these two drugs in treating COVID-19. 2020-04-13
Reply to: “Reporting of all cardiac medications and their outcome in COVID-19”. Ajay Kumar Mishra and his colleagues for their attention to our review.1, 2 We strongly agree with them that it is inappropriate for COVID-19 patients to discontinue ACEIs /ARBs without weighing up the pros and cons.3, 4 Whether the RAAS inhibitors may affect the prognosis of COVID-19 patients still needs more clinical trials to confirm. 2020-04-13
Coronavirus disease 2019: new things to know! " 1 which report the clinical features, diagnosis and treatment of the novel Coronavirus Disease 2019 (COVID-19). 2020-04-13
C-reactive protein correlates with CT findings and predicts severe COVID-19 early. Clinical parameters were collected from electronic medical records. 2020-04-13
COVID-19 and gastrointestinal endoscopies: current insights and emergent strategies. Given these risks, all major GI societies have called for rescheduling elective non-urgent procedures and perform only emergent or urgent based on the clinical need. 2020-04-13
Existing bitter medicines for fighting 2019-nCoV-associated infectious diseases. To quickly guide the clinical treatment of 2019-nCoV, we searched currently available drugs that are agonists of TAS2Rs. […] We identified many cheap, available, and safe medicines, such as diphenidol, quinine, chloroquine, artemisinin, chlorpheniramine, yohimbine, and dextromethorphan, which may target the most common symptoms caused by 2019-nCoV. 2020-04-13
An account of the first hours of the Covid-19 epidemic at the Nephrology Unit in Lodi (Lombardy). After an overview of the clinical conditions of the 7 patients positive to the virus hospitalised in the following few days, they describe in some detail how symptomatic Covid+ patients are currently managed at the Ospedale Maggiore in Lodi. 2020-04-16
Covid-19 and its impact on nephropathic patients: the experience at Ospedale “Guglielmo da Saliceto” in Piacenza. Roberto Scarpioni and colleagues recount their experience with the Covid-19 epidemic at the Nephrology and Dialysis Center of the “Guglielmo da Saliceto” Hospital in Piacenza, where everybody is still fighting to this moment to contain the spread of the disease and face an increasingly unsustainable clinical situation. 2020-04-16
[Covid-19 in patients on dialysis: infection prevention and control strategies]. Covid-19 is a disease caused by a new coronavirus presenting a variability of flu-like symptoms including fever, cough, myalgia and fatigue; in severe cases, patients develop pneumonia, acute respiratory distress syndrome, sepsis and septic shock, that can result in their death. […] In patients with full-blown symptoms, there is a renal impairment of various degrees in 100% of the subjects observed. 2020-04-16
Dual-Functional Plasmonic Photothermal Biosensors for Highly Accurate Severe Acute Respiratory Syndrome Coronavirus 2 Detection. In this work, a dual-functional plasmonic biosensor combining the plasmonic photothermal (PPT) effect and localized surface plasmon resonance (LSPR) sensing transduction provides an alternative and promising solution for the clinical COVID-19 diagnosis. 2020-04-16
Pharmacologic Treatments for Coronavirus Disease 2019 (COVID-19): A Review. Given the rapid pace of scientific discovery and clinical data generated by the large number of people rapidly infected by SARS-CoV-2, clinicians need accurate evidence regarding effective medical treatments for this infection. […] Current clinical evidence does not support stopping angiotensin-converting enzyme inhibitors or angiotensin receptor blockers in patients with COVID-19. […] The speed and volume of clinical trials launched to investigate potential therapies for COVID-19 highlight both the need and capability to produce high-quality evidence even in the middle of a pandemic. 2020-04-13
The VACCINES Act: Deciphering Vaccine Hesitancy in the Time of COVID-19. With several vaccine candidates already being tested in clinical trials, we pose the question: what will the vaccine hesitant do in the face of this pandemic? 2020-04-14
A Case of COVID-19 Pneumonia in a Young Male with Full Body Rash as a Presenting Symptom. We describe a case of COVID-19 pneumonia requiring hospitalization that presented with fever and extensive rash as the primary presenting symptoms. 2020-04-13
One Academic Health System’s Early (and Ongoing) Experience Responding to COVID-19: Recommendations From the Initial Epicenter of the Pandemic in the United States. That same day, a skilled nursing and rehabilitation facility in the county reported that several of its residents tested positive for SARS-CoV-2 and that many staff had symptoms compatible with COVID-19. […] Tapping into the multipronged mission areas of academic medicine, UW Medicine worked to support the community, innovate in science and clinical practice, lead policy and practice guideline development, and adopt changes as the crisis unfolded. 2020-04-13
Innovation in Response to the COVID-19 Pandemic Crisis. The author of this Invited Commentary anticipates that at least some of these innovations will become part of academic medicine’s everyday clinical and educational operations. […] Here he considers the implications of exemplary innovations-virtual care, hospital at home, advances in diagnosis and therapy, virtual learning, and virtual clinical learning-for regulators, academic medical centers, faculty, and students. 2020-04-13
Medical Student Mobilization During A Crisis: Lessons From A COVID-19 Medical Student Response Team. Given this change, medical students nationwide had to grapple with how and where they could fill the evolving needs of their schools’ affiliated clinical sites, physicians, and patients and the community. […] The HMS student volunteers joined any of the 4 virtual committees to complete this work: Education for the Medical Community, Education for the Broader Community, Activism for Clinical Support, and Community Activism. 2020-04-13
COVID-19 in Children in the United States: Intensive Care Admissions, Estimated Total Infected, and Projected Numbers of Severe Pediatric Cases in 2020. Empirical case projection study MAIN OUTCOMES AND MEASURES:: Adjusted pediatric severity proportions and adjusted pediatric criticality proportions were derived from clinical and spatiotemporal modelling studies of the COVID-19 epidemic in China for the period Jan-Feb 2020. 2020-04-13
Peri-operative Considerations in Urgent Surgical Care of Suspected and Confirmed COVID-19 Orthopedic Patients: Operating rooms protocols and recommendations in the Current COVID-19 Pandemic. This article provides evidence-based recommendations and measures for the appropriate personal protective equipment for different clinical and surgical activities in various settings. 2020-04-14
Cardiovascular Considerations in Treating Patients with Coronavirus (COVID-19). No established treatment is currently available; however, several therapies, including remdesivir, hydroxychloroquine and chloroquine, and interleukin (IL)-6 inhibitors, are being used off-label and evaluated in ongoing clinical trials. 2020-04-13
Diagnostic Testing for Severe Acute Respiratory Syndrome-Related Coronavirus-2: A Narrative Review. Urgent clinical and public health needs currently drive an unprecedented global effort to increase testing capacity for SARS-CoV-2 infection. 2020-04-13
Latin American healthcare systems in times of pandemic. As ethical expertise in Latin America focuses on research ethics, few hospitals in the region have functioning clinical ethics committees or clinical ethics policy, forcing healthcare personnel to make excruciating treatment decisions in an environment dominated by material scarcity and public distrust. 2020-04-14
Early Impact of COVID-19 on Transplant Center Practices and Policies in the United States. To understand the impact on transplant activity across the US, and center-level variation in testing, clinical practice, and policies, we conducted a national survey between March 24-31, 2020 and linked responses to the COVID-19 incidence map. […] There is wide heterogeneity in center-level response across the US; ongoing national data collection, expert discussion, and clinical studies are critical to informing evidence-based practices. 2020-04-13
SARS-CoV-2: Olfaction, Brain Infection, and the Urgent Need for Clinical Samples Allowing Earlier Virus Detection. We propose that the olfactory epithelium from the nasal cavity may be a more appropriate tissue for detection of SARS-CoV-2 virus at the earliest stages, prior to onset of symptoms or even in asymptomatic people, as compared to commonly used sputum or nasopharyngeal swabs. 2020-04-13
AGA Clinical Practice Update on Management of Inflammatory Bowel Disease During the COVID-19 Pandemic: Expert Commentary. The purpose of this AGA Institute Clinical Practice Update is to rapidly review the emerging evidence and provide timely expert recommendations regarding the management of patients with inflammatory bowel disease during the COVID-19 pandemic. […] This expert commentary was commissioned and approved by the AGA Institute Clinical Practice Updates Committee (CPUC) and the AGA Governing Board to provide timely perspective on a topic of high clinical importance to the AGA membership, and underwent internal peer review by the CPUC and external peer review through standard procedures of Gastroenterology. 2020-04-15
Household Transmission of SARS-CoV-2. Epidemiological, clinical and laboratory data of the household members were collected. […] There were 155 close contacts in total. 104 contacts received RT-PCR assays, with 47 (30%) positive cases and 57 (37%) negative cases. 51 (33%) cases did not received RT-PCR tests for they showed no symptoms of pneumonia during the 2 weeks of quarantine. 2020-04-16
Serological immunochromatographic approach in diagnosis with SARS-CoV-2 infected COVID-19 patients. In conclusion, serological ICG strip assay in detecting SARS-CoV-2 infection is both sensitive and consistent, which is considered as an excellent supplementary approach in clinical application. 2020-04-13
Arbidol Monotherapy is Superior to Lopinavir/ritonavir in Treating COVID-19. Lopinavir/ritonavir and arbidol have been previously used to treat acute respiratory syndrome- coronavirus 2 (SARS-CoV-2) replication in clinical practice; nevertheless, their effectiveness remains controversial. 2020-04-13
Evolutionary analysis of SARS-CoV-2: how mutation of Non-Structural Protein 6 (NSP6) could affect viral autophagy. A Maximum likelihood tree has been built and selective pressure has been investigated in order to find any mutation developed during the SARS-CoV-2 epidemic that could potentially affect clinical evolution of the infection. 2020-04-13
Cytokine Storm in COVID-19 and Treatment. This article reviews the occurrence mechanism and treatment strategies of the COVID-19 virus-induced inflammatory storm in attempt to provide valuable medication guidance for clinical treatment. 2020-04-13
Clinical characteristics of coronavirus disease 2019 (COVID-19) in China: a systematic review and meta-analysis. Among COVID-19 patients, fever (83.3% [95% CI 78.4-87.7]), cough (60.3% [54.2-66.3]), and fatigue (38.0% [29.8-46.5]) were the most common clinical symptoms. […] Patients living in Wuhan, older patients, and those with medical comorbidities tend to have more severe clinical symptoms and higher CFR. 2020-04-16
Rapid asymptomatic transmission of COVID-19 during the incubation period demonstrating strong infectivity in a cluster of youngsters aged 16-23 years outside Wuhan and characteristics of young patients with COVID-19: a prospective contact-tracing study. His very first symptoms were itchy eyes and fever developed at noon and in the afternoon on January 22, respectively. 2020-04-13
Neutrophil-to-lymphocyte ratio as an independent risk factor for mortality in hospitalized patients with COVID-19. Several studies have described the clinical characteristics of patients with novel coronavirus (SARS-CoV-2)-infected pneumonia (COVID-19), indicating severe patients tended to have higher neutrophil to lymphocyte ratio (NLR). 2020-04-13
A cluster of the Corona Virus Disease 2019 caused by incubation period transmission in Wuxi, China. As of March 11, the fourth-generation cases had no symptoms. 2020-04-14
Mortality of a pregnant patient diagnosed with COVID-19: A case report with clinical, radiological, and histopathological findings. Finally, due to deterioration in the clinical and imaging findings, the patient was expired as a result of multi-organ failure. 2020-04-16
The Family Caregiving Crisis Meets an Actual Pandemic. Our commentary provides rationale for the need to focus on family caregivers and key considerations for how to include them in pandemic clinical decision making. 2020-04-14
Clinical Features of COVID-19-Related Liver Damage. We aimed to clarify the features of COVID-19-related liver damage to provide references for clinical treatment. […] We performed a retrospective, single-center study of 148 consecutive patients with confirmed COVID-19 (73 female, 75 male; mean age, 50 years) at the Shanghai Public Health Clinical Center from January 20 through January 31, 2020. […] Patients were analyzed for clinical features, laboratory parameters (including liver function tests), medications, and length of hospital stay. 2020-04-13
COVID-19: From bench to bed side. We aimed to delineate the differences in viral dynamics and clinical features between them and tried to focus on every basic details of SARS-COV-2 (COVID-19) that every health care provider must know. […] Ample data is available to suggest the differences in etiology, transmission cycle, diagnosis, genetics, hosts, reproductive rates, clinical features, laboratory diagnosis and radiological features between SARS-CoV-1, MERS-CoV and SARS-CoV-2. 2020-04-15
[Prognostic value of myocardial injury in patients with COVID-19]. Objective: To analyze the prognostic value of myocardial injury in patients with COVID-19. Method: Confirmed cases of COVID-19 patients admitted from January 31st to February 5th at isolation ward of Renmin Hospital of Wuhan University were divided into non-survival group and survival group according to the clinical outcomes 5 weeks after admission. 2020-04-14
[Whether conjunctival congestion in patients infected with 2019 novel coronavirus is definitely related the novel coronavirus?] Currently, it is commonly reported that COVID-19 patients are associated with conjunctival congestion and other symptoms, and the transmission route or high-risk diseases of ophthalmology and high-risk working status are speculated. […] Are conjunctival congestion or conjunctival related symptoms in patients with 2019 novel coronavirus definitely related the novel coronavirus? […] Conjunctival congestion is one of the common clinical signs of various types of conjunctivitis. […] The symptoms and signs of conjunctivitis in COVID-19 patients may be related to a variety of factors. […] Therefore, conjunctival symptoms should not be associated with 2019 novel coronavirus without evidence. ( Chin J Ophthalmol, 2020, 56: ). 2020-04-14
Clinical Presentation of COVID-19: A Systematic Review Focusing on Upper Airway Symptoms. Pharyngodynia, nasal congestion, rhinorrhea, smell, and taste dysfunctions could be the presenting symptoms of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2. […] The aim was to perform a systematic review of current evidences on clinical presentation of COVID-19, focusing on upper airway symptoms in order to help otolaryngologists identifying suspected cases. […] We included 5 retrospective clinical studies for a total of 1556 hospitalized patients with COVID-19, 57.5% were male and mean age was 49.1 years. […] Common symptoms were fever (85.6%), cough (68.7%), and fatigue (39.4%). […] Otolaryngologists should know that pharyngodynia, nasal congestion, olfactory, and gustative disorders could be the presenting symptoms of COVID-19. […] Clinical presentation together with radiological and laboratory findings could help to identify suspected cases. 2020-04-14
Keratoconjunctivitis as the initial medical presentation of the novel coronavirus disease 2019 (COVID-19). The patient’s primary symptom was a red eye with watery discharge, though she did have mild respiratory symptoms, without fever. 2020-04-16
The COVID-19 pandemic: implications for the cytology laboratory. The alarming spread of the infection and the severe clinical disease that it may cause have led to the widespread institution of social distancing measures. 2020-04-16
COVID-19 and neuromuscular disorders. In a short period of time, it has already caused reorganization of neuromuscular clinical care delivery and education, which will likely have lasting impact on the field. […] We outline key unanswered clinical questions and highlight the need for team-based and inter-specialty collaboration. […] Primary goals of clinical research during this time are to develop evidence-based best practices and to minimize morbidity and mortality related to COVID-19 for patients with neuromuscular disorders. 2020-04-14
Characteristics of pediatric SARS-CoV-2 infection and potential evidence for persistent fecal viral shedding. We report epidemiological and clinical investigations on ten pediatric SARS-CoV-2 infection cases confirmed by real-time reverse transcription PCR assay of SARS-CoV-2 RNA. […] Symptoms in these cases were nonspecific and no children required respiratory support or intensive care. 2020-04-16
Estimating clinical severity of COVID-19 from the transmission dynamics in Wuhan, China. A key public health priority during the emergence of a novel pathogen is estimating clinical severity, which requires properly adjusting for the case ascertainment rate and the delay between symptoms onset and death. […] Using public and published information, we estimate that the overall symptomatic case fatality risk (the probability of dying after developing symptoms) of COVID-19 in Wuhan was 1.4% (0.9-2.1%), which is substantially lower than both the corresponding crude or naïve confirmed case fatality risk (2,169/48,557 = 4.5%) and the approximator1 of deaths/deaths + recoveries (2,169/2,169 + 17,572 = 11%) as of 29 February 2020. […] Compared to those aged 30-59 years, those aged below 30 and above 59 years were 0.6 (0.3-1.1) and 5.1 (4.2-6.1) times more likely to die after developing symptoms. 2020-04-16
Coronavirus Disease 2019 Treatment: A Review of Early and Emerging Options. It is important to caution readers that new data emerges daily regarding clinical characteristics, treatment options, and outcomes for COVID-19. […] Optimized supportive care remains the mainstay of therapy, and the clinical efficacy for the subsequent agents is still under investigation. […] We encourage all readers to continue to assess clinical data as it emerges and share their experience within our community in a well-controlled, adequately powered fashion. 2020-04-16
Three unsuspected CT diagnoses of COVID-19. Three patients were imaged for non-respiratory-related symptoms with a portion of the lungs in the imaged field. 2020-04-14
Searching therapeutic strategy of new coronavirus pneumonia from angiotensin-converting enzyme 2: the target of COVID-19 and SARS-CoV. An in-depth understanding of ACE2 and a series of physiological and physiological changes caused by the virus invading the human body may help to discover and explain the corresponding clinical phenomena and then deal with them timely. 2020-04-14
Clinical characteristics of 19 neonates born to mothers with COVID-19. The aim of this study was to investigate the clinical characteristics of neonates born to SARS-CoV-2 infected mothers and increase the current knowledge on the perinatal consequences of COVID-19. […] None of the neonates developed clinical, radiologic, hematologic, or biochemical evidence of COVID-19. 2020-04-14
From the handling of an outbreak by an unknown pathogen in Wuhan to the preparedness and response in the face of the emergence of Covid-19 in Mexico. The publication of full-genomes of the newly identified coronavirus (initially called 2019-nCoV, now called SARS-CoV2) in public and private databases, of standardized diagnostic protocols and of the clinical-epidemiological information generated will allow addressing the Public Health Emergency of International Concern (PHEIC), declared on January 30 by the WHO. 2020-04-16
Optimizing hydroxychloroquine dosing for patients with COVID-19: An integrative modeling approach for effective drug repurposing. The data sources included were 1) longitudinal clinical, pharmacokinetic, and virologic data from patients with severe acute respiratory syndrome-2 (SARS-CoV-2) infection who received HCQ with or without azithromycin (n=116), 2) in vitro viral replication data and SARS-CoV-2 viral load inhibition by HCQ, 3) a population pharmacokinetic model of HCQ and 4) a model relating chloroquine pharmacokinetics to QTc prolongation. […] This prolongation may have clinical implications warranting further safety assessment. 2020-04-14
Mental health burden for the public affected by the COVID-19 outbreak in China: Who will be the high-risk group? Data were collected from 7,236 self-selected participants measured by anxiety symptoms, depressive symptoms, and sleep quality. […] The overall prevalence of anxiety symptoms, depressive symptoms, and poor sleep quality were 35.1%, 20.1%, and 18.2%, respectively. […] People aged < 35 years reported a higher prevalence of anxiety symptoms and depressive symptoms than people aged ≥ 35 years. […] Healthcare workers/younger people who spent a high level of time (≥ 3 hours/day) had a particular higher prevalence of anxiety symptoms than in those who spent less time (< 1 hours/day and 1-2 hours/day) on the outbreak. 2020-04-14
Significance of Serology Testing to Assist Timely Diagnosis of SARS-CoV-2 infections: Implication from a Family Cluster. We comprehensively analyzed this familial cluster of cases based on the clinical characteristics, chest CT images, SARS-CoV-2 molecular detection results, and serology testing results. 2020-04-14
[Fatal outcome of coronavirus disease 2019 in a previously healthy 50-year-old man]. In this case report, a 50-year-old man who had no medical history, presented with multiple cardiac arrests following a week with progressing symptoms of pneumonia. […] In conclusion: coronavirus disease 2019 (COVID-19) can lead to a fatal outcome in younger healthy residents, who are not treated timely in case of severe symptoms like dyspnoea. 2020-04-16
[Possible unregistered SARS-CoV-2 infection in a young man with anosmia and ageusia]. Besides the well-known symptoms of SARS-CoV-2, this case also reports total anosmia and ageusia. 2020-04-16
Hematologic, biochemical and immune biomarker abnormalities associated with severe illness and mortality in coronavirus disease 2019 (COVID-19): a meta-analysis. Background As coronavirus disease 2019 (COVID-19) pandemic rages on, there is urgent need for identification of clinical and laboratory predictors for progression towards severe and fatal forms of this illness. 2020-04-14
Inhibitors of the renin-angiotensin system: The potential role in the pathogenesis of COVID-19. The clinical effect of ACEIs/ARBs on patients with COVID-19 is still uncertain. 2020-04-14
COVID-19 challenge for modern medicine. Human coronaviruses (HCoV) are mainly known to cause infections of the upper and lower respiratory tract but the symptoms may also involve the nervous and digestive systems. […] The most common symptoms are fever and cough, fatigue, sputum production, dyspnea, myalgia, arthralgia or sore throat, headache, nausea, vomiting or diarrhea (30%). 2020-04-14
COVID-19 Pandemic: What Every Otolaryngologist-Head and Neck Surgeon Needs to Know for Safe Airway Management. This commentary provides background on the outbreak, highlights critical considerations around mitigating infectious aerosol contact, and outlines best practices for airway-related clinical decision making during the COVID-19 pandemic. 2020-04-14
Otolaryngology Providers Must Be Alert for Patients with Mild and Asymptomatic COVID-19. Otolaryngology providers should maintain high clinical suspicion for mild and asymptomatic COVID-19 patients. 2020-04-14
COVID-19 Pandemic: Experiences in China and implications for its prevention and treatment worldwide. In this article, we systematically review the brief history of COVID-19 and its epidemic and clinical characteristics, highlighting the strategies used to control and prevent the disease in China, which may help other countries respond to the outbreak. 2020-04-14
Cloud-Based System for Effective Surveillance and Control of COVID-19: Useful Experiences From Hubei, China. Tools that can improve the focus of surveillance efforts and clinical decision support are of paramount importance. […] HHS supports four main features: syndromic surveillance on mobile devices, policy-making decision support, clinical decision support and prioritization of resources, and follow-up of discharged patients. […] The clinical decision support component in HHS was also provided to improve patient care and prioritize the limited medical resources. […] However, the statistical methods still require further evaluations to confirm clinical effectiveness and appropriateness of disposition assigned in this study, which warrants further investigation. 2020-04-14
COVID-19: Financial Stress Test for Academic Medical Centers. As the nation’s safety net health care systems, academic medical centers (AMCs) are vital clinical and academic resources in managing the pandemic. […] COVID-19 may also risk the financial underpinnings of AMCs because their cost structures are high, and they may have incurred large amounts of debt over the last decade as they expanded their clinical operations and facilities. 2020-04-14
Clinical Characteristics of COVID-19 Patients With Digestive Symptoms in Hubei, China: A Descriptive, Cross-Sectional, Multicenter Study. Since the outbreak of Coronavirus Disease 2019 (COVID-19) in December 2019, various digestive symptoms have been frequently reported in patients infected with the virus. […] In this study, we aimed to further investigate the prevalence and outcomes of COVID-19 patients with digestive symptoms. […] All patients were confirmed by real-time polymerase chain reaction and were analyzed for clinical characteristics, laboratory data, and treatment. […] Although most patients presented to the hospital with fever or respiratory symptoms, we found that 103 patients (50.5%) reported a digestive symptom, including lack of appetite (81 [78.6%] cases), diarrhea (35 [34%] cases), vomiting (4 [3.9%] cases), and abdominal pain (2 [1.9%] cases). […] Patients with digestive symptoms had a significantly longer time from onset to admission than patients without digestive symptoms (9.0 days vs 7.3 days). […] In 6 cases, there were digestive symptoms, but no respiratory symptoms. […] As the severity of the disease increased, digestive symptoms became more pronounced. […] Patients with digestive symptoms had higher mean liver enzyme levels, lower monocyte count, longer prothrombin time, and received more antimicrobial treatment than those without digestive symptoms. […] We found that digestive symptoms are common in patients with COVID-19. […] Clinicians should recognize that digestive symptoms, such as diarrhea, are commonly among the presenting features of COVID-19 and that the index of suspicion may need to be raised earlier in at-risk patients presenting with digestive symptoms. 2020-04-14
Herbal medicine and pattern identification for treating COVID-19: a rapid review of guidelines. Clinical evidence is needed in the future to evaluate the efficacy of traditional medicine. 2020-04-16
A comprehensive Chinese experience against SARS-CoV-2 in ophthalmology. Based on 33 articles published by Chinese scholars, guidelines and clinical practice experience in domestic hospitals, we have summarized the Chinese experience through the lens of ophthalmology, hoping to make a contribution to protecting ophthalmologists and patients around the world. 2020-04-16
An Infectious cDNA Clone of SARS-CoV-2. Compared with a clinical isolate, the infectious-clone-derived SARS-CoV-2 (icSARS-CoV-2) exhibited similar plaque morphology, viral RNA profile, and replication kinetics. 2020-04-14
The evidence of SARS-CoV-2 infection on ocular surface. A total of 102 patients (48 Male [47%] and 54 Female [53%]) with clinical symptoms, Rt, and chest Computed Tomography (CT) abnormalities were identified with a clinical diagnosis of COVID-19. 2020-04-14
COVID-19 in the perioperative period of lung resection: a brief report from a single thoracic surgery department in Wuhan, China. Clinical information on patients contracted with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in the perioperative period is limited. […] Fever, lymphopenia and ground-glass opacities on computerized tomography (CT) are the most common clinical manifestations of COVID-19 in patients after lung resection surgery. 2020-04-14
Clinical and microbiological effect of a combination of hydroxychloroquine and azithromycin in 80 COVID-19 patients with at least a six-day follow up: A pilot observational study. We conducted an uncontrolled non-comparative observational study in a cohort of 80 relatively mildly infected inpatients treated with a combination of hydroxychloroquine and azithromycin over a period of at least three days, with three main measurements: clinical outcome, contagiousness as assessed by PCR and culture, and length of stay in infectious disease unit (IDU). 2020-04-16
Epidemiological and clinical features of 125 Hospitalized Patients with COVID-19 in Fuyang, Anhui, China. To investigate the epidemiological and clinical features of patients with COVID-19 in Anhui province of China. […] Clinical outcomes were followed up to Feb 18, 2020. […] Common symptoms include fever [116 (92.8%)], cough [102(81.6%)], and shortness of breath [57(45.6%)]. 2020-04-16
A Rational Use of Clozapine Based on Adverse Drug Reactions, Pharmacokinetics, and Clinical Pharmacopsychology. Using Richardson and Davidson’s model and the sciences of pharmacokinetics and clinical pharmacopsychology, this article reviewed the: (1) poor life expectancy associated with treatment-resistant schizophrenia (TRS), which may be improved in patients who adhere to clozapine; (2) findings that clozapine is the best treatment for TRS (according to efficacy, effectiveness and well-being); and (3) potential for clozapine to cause vulnerabilities, including potentially lethal adverse drug reactions such as agranulocytosis, pneumonia, and myocarditis. […] Psychiatrists should call their clozapine patients and families and explain to them that if the patient develops fever or flu-like symptoms, the psychiatrist should be called and should consider halving the clozapine dose. […] If the patient is hospitalized with pneumonia, the treating physician needs to assess for symptoms of clozapine intoxication since halving the dose may not be enough for all patients; consider decreasing it to one-third or even stopping it. 2020-04-14
A Review of SARS-CoV-2 and the Ongoing Clinical Trials. In this article, we present a succinct overview of the epidemiology, clinical features, and molecular characteristics of SARS-CoV-2. […] We summarize the current epidemiological and clinical data from the initial Wuhan studies, and emphasize several features of SARS-CoV-2, which differentiate it from SARS-CoV and Middle East respiratory syndrome coronavirus (MERS-CoV), such as high variability of disease presentation. […] We systematize the current clinical trials that have been rapidly initiated after the outbreak of COVID-19 pandemic. […] The initial clinical studies revealed the promising therapeutic potential of several of such drugs, including favipiravir, a broad-spectrum antiviral drug that interferes with the viral replication, and hydroxychloroquine, the repurposed antimalarial drug that interferes with the virus endosomal entry pathway. 2020-04-16
COVID-19: A Brief Overview of the Discovery Clinical Trial. This short communication focuses on four treatments recommended by WHO and included in the first clinical trial of the European Discovery project. 2020-04-15
Clinical and epidemiologic profile of the initial COVID-19 patients at a tertiary care centre in India. The objective of this work is to report the initial experience with epidemiologic and clinical features, as well as with the management of COVID-19 patients in India. […] Clinical, laboratory, and radiologic data were collected, including age, sex, nationality, travel history, symptoms, duration of stay, and comorbidities. […] The most common symptoms were fever and cough (42.9%) followed by sore throat, headache and breathlessness. […] Among the first 21 patients diagnosed with COVID-19 infection in India, the typical clinical presentation consisted in a mild upper respiratory tract infection predominantly affecting the young male population. […] All patients recovered with no residual symptoms. 2020-04-16
Why tocilizumab could be an effective treatment for severe COVID-19? Moreover, Tocilizumab treatment that blocking IL-6 receptors showed inspiring clinical results including temperature returned to normal quickly and respiratory function improved. 2020-04-16
Ongoing Clinical Trials for the Management of the COVID-19 Pandemic. Hundreds of clinical studies have been registered with the intention of discovering effective treatments. […] Here, we review currently registered interventional clinical trials for the treatment and prevention of COVID-19 to provide an overall summary and insight into the global response. 2020-04-15
Can we use interleukin-6 (IL-6) blockade for coronavirus disease 2019 (COVID-19)-induced cytokine release syndrome (CRS)? We propose to utilize interleukin-6 (IL-6) blockade to manage COVID-19-induced CRS and discuss several factors that should be taken into consideration for its clinical application. 2020-04-15
Suspected myocardial injury in patients with COVID-19: Evidence from front-line clinical observation in Wuhan, China. We enrolled patients with confirmed diagnosis of COVID-19 retrospectively and collected heart-related clinical data, mainly including cardiac imaging findings, laboratory results and clinical outcomes. […] The clinical evidence in our study suggested that myocardial injury is more likely related to systemic consequences rather than direct damage by the 2019 novel coronavirus. […] The elevation in cardiac markers was probably due to secondary and systemic consequences and can be considered as the warning sign for recent adverse clinical outcomes of the patients. 2020-04-15
Repurposing Didanosine as a Potential Treatment for COVID-19 Using Single-Cell RNA Sequencing Data. There is no approved drug or vaccine for COVID-19, although more than 10 clinical trials have been launched to test potential drugs. 2020-04-15
Diagnosing COVID-19: Did We Miss Anything? In late 2019, a mass of patients showing symptoms of a pneumonia-like disease of unknown origin emerged in Wuhan, China. 2020-04-16
Gastrointestinal Presentation in COVID-19 in Indonesia: A Case Report. During the pandemic, physicians may need to raise the index of suspicion earlier in at-risk patients presenting with gastrointestinal symptoms, which are uncommon findings in coronavirus disease 2019 (COVID-19) patients. […] We report a patient in Indonesia with chest pain and gastrointestinal symptoms who was later confirmed to have SARS-CoV-2 infection after spending days of hospitalisation in the standard ward. 2020-04-16
The Importance of Chest CT Scan in COVID-19. The objective of this case study is to investigate the importance and utility of chest computed tomography (CT) in the diagnosis of COVID-19, as increasing pieces of evidence suggest that chest CT could prove useful in the clinical pathway in diagnosing COVID-19. 2020-04-16
Clinical Progression of COVID-19 Patient with Extended Incubation Period, Delayed RT-PCR Time-to-positivity, and Potential Role of Chest CT-scan. COVID-19 symptom is highly various in each patient, with fever, fatigue, shortness of breath, and cough as the main presenting symptoms. 2020-04-16
Coronavirus Vaccines: Light at the End of the Tunnel. Various challenges associated with developing a vaccine during the pandemic such as technological hurdles, clinical development pathways, regulatory issues, and support from global funding agencies are expressed here. 2020-04-15
CT features of novel coronavirus pneumonia (COVID-19) in children. This review is mainly about the differences in clinical symptom spectrum, diagnosis of COVID-19, and CT imaging findings between adults and children, while highlighting the value of radiology in prevention and control of COVID-19 in pediatric patients. […] KEY POINTS: • Compared with adults, pediatric patients with COVID-19 have the characteristics of lower incidence, slighter clinical symptoms, shorter course of disease, and fewer severe cases. 2020-04-15
Evolution of CT findings in patients with mild COVID-19 pneumonia. CT images and medical records of 88 patients with confirmed mild COVID-19 pneumonia, a baseline CT, and at least one follow-up CT were retrospectively reviewed. […] The most common symptoms were fever (84.1%) and cough (56.8%). 2020-04-15
German recommendations for critically ill patients with COVID‑19. The majority of patients presents with mild symptoms of coronavirus disease 2019 (COVID-19). 2020-04-15
The epidemiology and clinical information about COVID-19. In this review, we summarized the epidemiological characteristics, clinical features, diagnosis, treatment, and prognosis of COVID-19. 2020-04-15
[Application of tracheotomy in the treatment of severe cases of COVID-19]. Objective: Todiscuss the the effects, indications and protective measures of tracheotomy for severe cases of 2019 novel corona virus disease(COVID-19)patients. Methods: A retrospectively analyze was conducted to explore the clinical data of ofCOVID-19 patients who received tracheotomy in February to March 2020,descriptive statistics were used to analyze the indication of tracheotomy, particularity of intraoperative treatment and protective measures. Results: A total of 4 cases were included in this article, 3 cases were successfully operated, 1 case of postoperative incision continuous bleeding, there were not other complications and nosocomial infection among the medical staff.the patient’s condition was relieved in different degrees after the operation, who remain hospitalized. Conclusion: Tracheotomy for severe cases of COVID-19 can achieve certain curative effect, but the occurrence of tracheotomy related complicationsand nosocomial infection should be effectively controlled, and the risk benefit ratio of tracheotomy should be carefully weighed before surgery. 目的: 探讨新型冠状病毒肺炎危重型患者施行气管切开术的指征、术中处理的特殊性及防护措施。 2020-04-15
[Distributions of time, place, and population of novel coronavirus disease 2019 (COVID-19) from January 20 to February 10, 2020, in China]. General demographic characteristics, epidemiological history, and clinical symptoms of COVID-19 were collected that had been reported on the websites of multiple Municipal Health Commissions in China. 2020-04-15
[Coronavirus: from common cold to severe pulmonary failure]. The clinical course of the disease known as coronavirus disease 2019 (COVID-19) ranges from mild respiratory symptoms to severe lung failure. […] Molecular diagnostic methods have been established in a very short time and a number of clinical studies on the effectiveness of different antiviral drugs are ongoing. 2020-04-15
Coronavirus 101. Symptoms of COVID-2019 include cough, fever, and shortness of breath. […] Primary care providers must be alert to respiratory symptoms they encounter that are associated with pertinent travel history, be prepared to safely screen, examine and possibly test and/or report suspicions to the health department for further evaluation. 2020-04-15
CT Scans of Patients with 2019 Novel Coronavirus (COVID-19) Pneumonia. The clinical outcomes were monitored up to February 11, 2020. […] Three kinds of responses to clinical treatment were defined and evaluated: 1) good, symptoms continually improved; 2) fair, symptoms not improved or relapsed; 3) poor, symptoms aggravated. […] The risk factors, including basal clinical characteristics, CT imaging features, and follow-up CT changes (no change, progress, and improvement) related to poor/fair outcomes, were also investigated. Results: Six patients were improved to no-emergency type, 2 remained the same, and 2 progressed to fatal type. […] The progression in abnormal imaging findings indicate a poor/fair response, whereas the alleviated symptoms seen from CT suggest a good response. Conclusion: Most cases are no-emergency type and have a favorable response to clinical treatment. 2020-04-16
Highlights of traditional Chinese medicine frontline expert advice in the China national guideline for COVID-19. We extracted the case definition and clinical classifications of COVID-19 in China along with relevant TCM treatments cited in the seventh edition of the guideline, with an intend to disseminate practical information to TCM practitioners and researchers around the world. […] We presented the most recent case definition, clinical classifications, and relevant TCM treatments of COVID-19 in accordance to recommendations of the Chinese guideline. […] Several herbal formulae are recommended for confirmed COVID-19 cases according to their clinical classification and TCM pattern diagnoses. 2020-04-15
Mutated COVID-19, May Foretells Mankind in a Great Risk in the Future. The highly prevalence of COVID-19 is due to the lack onset of symptoms. […] Our study aimed to present an overview of the virus in terms of structure, epidemiology, symptoms, treatment, and prevention. 2020-04-15
Core Outcome Set for Clinical Trials on Coronavirus Disease 2019 (COS-COVID). Since its outbreak in December 2019, a series of clinical trials on Coronavirus Disease 2019 (COVID-19) have been registered or carried out. […] This study aimed to develop a core outcome set (COS) for clinical trials on COVID-19 in order to tackle the outcome issues. […] A research group was set up that included experts in respiratory and critical medicine, traditional Chinese medicine, evidence-based medicine, clinical pharmacology, and statistics, in addition to medical journal editors. […] Clinical trial registry websites ( and were searched to retrieve clinical trial protocols and outcomes in order to form an outcome pool. […] A total of 78 clinical trial protocols on COVID-19 were included and 259 outcomes were collected. […] After two rounds of Delphi survey and one consensus meeting, the most important outcomes for the different clinical classifications of COVID-19 were identified and determined to constitute the COS for clinical trials on COVID-19 (COS-COVID). […] The COS-COVID includes one outcome for the mild type (time to 2019-nCoV reverse transcription-polymerase chain reaction (RT-PCR) negativity), four outcomes for the ordinary type (length of hospital stay, composite events, score of clinical symptoms, and time to 2019-nCoV RT-PCR negativity), five outcomes for the severe type (composite events, length of hospital stay, arterial oxygen partial pressure (PaO2)/fraction of inspired oxygen (FiO2), duration of mechanical ventilation, and time to 2019-nCoV RT-PCR negativity), one outcome for critical type (all-cause mortality), and one outcome for rehabilitation period (pulmonary function). […] The COS-COVID is currently the most valuable and practical clinical outcome set for the evaluation of intervention effect, and is useful for evidence assessment and decision-making. 2020-04-15
Clinical study of mesenchymal stem cell treating acute respiratory distress syndrome induced by epidemic Influenza A (H7N9) infection, a hint for COVID-19 treatment. MSCs transplant into patients with H7N9 induced ARDS were conducted in a single center and open-label clinical trial. […] Collectively, these results suggest that MSCs significantly improve survival rate of H7N9 induced ARDS and provide a theoretical basis for the treatment of H7N9 induced ARDS in both preclinical research and clinical studies. 2020-04-15
A study on the psychological needs of nurses caring for patients with coronavirus disease 2019 from the perspective of the existence, relatedness, and growth theory. It is found that the existence, relatedness, and growth needs coexist in clinical nurses. 2020-04-15
Holistic care for patients with severe coronavirus disease 2019: An expert consensus. This scientific and practical consensus guideline can provide clinical guidance on the holistic nursing care of patients with severe COVID-19. 2020-04-15
Coronavirus: Update Related to the Current Outbreak of COVID-19. Along with severe acute respiratory syndrome (SARS) and Middle Eastern respiratory syndrome (MERS), COVID-19 appears to cause a severe clinical picture in humans, ranging from mild malaise to death by sepsis/acute respiratory distress syndrome. 2020-04-15
Analysis of therapeutic targets for SARS-CoV-2 and discovery of potential drugs by computational methods. In addition, a database of 78 commonly used anti-viral drugs including those currently on the market and undergoing clinical trials for SARS-CoV-2 was constructed. […] This study will provide new lead compounds and targets for further in vitro and in vivo studies of SARS-CoV-2, new insights for those drugs currently ongoing clinical studies, and also possible new strategies for drug repositioning to treat SARS-CoV-2 infections. 2020-04-15
Emergence of deadly severe acute respiratory syndrome coronavirus-2 during 2019-2020. We have also provided information about the classification, genome, proteins, clinical presentation of COVID-19, type of clinical specimens to be collected and diagnostic methods adopted to identify the respiratory illness. […] Management of the ongoing outbreak of SARS-CoV-2 encompassing surveillance, clinical, immunological, genetic and evolutionary investigations are likely to provide the desired results. 2020-04-15
A living systematic review protocol for COVID-19 clinical trial registrations. Since the coronavirus disease 2019 (COVID-19) outbreak was identified in December 2019 in Wuhan, China, a strong response from the research community has been observed with the proliferation of independent clinical trials assessing diagnostic methods, therapeutic and prophylactic strategies. […] While there is no intervention for the prevention or treatment of COVID-19 with proven clinical efficacy to date, tools to distil the current research landscape by intervention, level of evidence and those studies likely powered to address future research questions is essential. […] This living systematic review aims to provide an open, accessible and frequently updated resource summarising the characteristics of COVID-19 clinical trial registrations. […] Weekly search updates of the WHO International Clinical Trials Registry Platform (ICTRP) and source registries will be conducted. […] This living systematic review will provide a useful resource of COVID-19 clinical trial registrations for researchers in a rapidly evolving context. 2020-04-15
Running a Radiation Oncology Department at the time of coronavirus: an Italian experience. Adopted preventive measures and recommendations are highlighted for patients, professionals and clinical operations to minimize the risk of infection while safely treating cancer patients. 2020-04-15
Prostate Cancer Radiotherapy Recommendations in Response to COVID-19. Recommendations are provided by National Comprehensive Cancer Network (NCCN) risk group, including clinical node positive, post-prostatectomy, oligometastatic, and low volume M1 disease. […] Unfavorable intermediate-risk, high-risk, clinical node positive, recurrence post-surgery, oligometastatic, and low-volume M1 disease can receive neoadjuvant hormone therapy for 4-6 months as necessary. […] Ultrahypofractionation was preferred for localized, oligometastatic, and low volume M1, and moderate hypofractionation was preferred for post-prostatectomy and clinical node positive disease. 2020-04-15
Breast radiotherapy under COVID-19 pandemic resource constraints – approaches to defer or shorten treatment from a Comprehensive Cancer Center in the United States. In the setting of a public health emergency with the potential to strain critical healthcare resources and place patients at infection risk, the parsimonious application of breast radiotherapy may alleviate a significant clinical burden without compromising long term oncologic outcomes. 2020-04-15
The Heart in COVID19: Primary Target or Secondary Bystander? Dealing with the immense challenge of COVID-19 disease, confronted with severely ill patients in dire straits with virtually no rigorous evidence base to guide our therapy, we must call upon our clinical skills and judgment. […] Lacking a robust evidence base, pathophysiologic reasoning can help guide our choices of therapy for individual clinical scenarios. 2020-04-15
COVID-19 for the Cardiologist: A Current Review of the Virology, Clinical Epidemiology, Cardiac and Other Clinical Manifestations and Potential Therapeutic Strategies. We review the most current data with a focus on our basic understanding of the mechanism(s) of disease and translation to the clinical syndrome and potential therapeutics. […] We discuss the basic virology, epidemiology, clinical manifestation, multi-organ consequences, and outcomes. 2020-04-15
Management Of Patients On Dialysis And With Kidney Transplant During SARS-COV-2 (COVID-19) Pandemic In Brescia, Italy. During the first phase of the disease (from onset of the symptoms up to 7-10 days) viral-induced effects are prominent with the opportunity to institute antiviral therapy. […] Furthermore, we provide some clinical and physiopathological background, as well as preliminary outcome data of our cohort, in order to better clarify the pathogenesis of the disease and clinical management. 2020-04-15
Progress and prospect on imaging diagnosis of COVID-19. In order to know about the progress and prospective on imaging of COVID-19, this review focus on interpreting the CT findings, stating the potential pathological basis, proposing the challenge of patients with underlying diseases, differentiating with other diseases and suggesting the future research and clinical directions, which would be helpful for the radiologists in the clinical practice and research. 2020-04-15
Coronavirus infections: Epidemiological, clinical and immunological features and hypotheses. Understanding the role of paucisymptomatic subjects and stratifying patients according to the risk of developing severe clinical presentations is pivotal for implementing reasonable measures to contain the infection and to reduce its mortality. 2020-04-15
Clinical characteristics and outcomes of patients undergoing surgeries during the incubation period of COVID-19 infection. We intended to describe their clinical characteristics and outcomes. […] We retrospectively analyzed the clinical data of 34 patients underwent elective surgeries during the incubation period of COVID-19 at Renmin Hospital, Zhongnan Hospital, Tongji Hospital and Central Hospital in Wuhan, from January 1 to February 5, 2020. […] Common symptoms included fever (31 [91·2%]), fatigue (25 [73·5%]) and dry cough (18 [52·9%]). 15 (44·1%) patients required admission to intensive care unit (ICU) during disease progression, and 7 patients (20·5%) died after admission to ICU. 2020-04-15
Pathogenic Priming Likely Contributes to Serious and Critical Illness and Mortality in COVID-19 via Autoimmunity. Mapping of the genes encoding human protein matches to pathways point to targets that could explain the observed presentation of symptoms in COVID-19 disease. 2020-04-15
Outcome of Coronavirus spectrum infections (SARS, MERS, COVID 1 -19) during pregnancy: a systematic review and meta-analysis. An overt diagnosis of pneumonia was made in 91.8% and the most common symptoms were fever (82.6%), cough (57.1%) and dyspnea (27.0%). […] None of the 41 newborns assessed showed clinical signs of vertical transmission. […] There have been no published cases of clinical evidence of vertical transmission. 2020-04-15
COVID-19 infection among asymptomatic and symptomatic pregnant women: Two weeks of confirmed presentations to an affiliated pair of New York City hospitals. Fourteen (32.6%) patients presented without any COVID-associated viral symptoms, and were identified either after developing symptoms during admission or following the implementation of universal testing for all obstetrical admissions on March 22. […] Of these, 10/14 (71.4%) developed symptoms or signs of COVID-19 infection over the course of their delivery admission or early after postpartum discharge. […] Of the other 29 (67.4%) patients who presented with symptomatic COVID-19 infection, three women ultimately required antenatal admission for viral symptoms, and an additional patient represented six days postpartum after a successful labor induction with worsening respiratory status that required oxygen supplementation. 2020-04-15
Coronavirus Disease 2019 (COVID-19) Pneumonia in a Hemodialysis Patient. This report describes the clinical characteristics of COVID-19 in an in-center hemodialysis patient, as well as our experience in implementing steps to prevent the spread of COVID-19 pneumonia among in-center hemodialysis patients. 2020-04-15
The role of afferent pulmonary innervation in poor prognosis of acute respiratory distress syndrome in COVID-19 patients and proposed use of resiniferatoxin (RTX) to improve patient outcomes in advanced disease state: A review. We also propose to further explore the use of resiniferatoxin (RTX), an ultra-potent TRPV1 agonist currently in clinical trials for cancer and osteoarthritis pain, as a possible ablating agent of TRPV1 positive pulmonary pathways in patients with advanced COVID-19 disease. 2020-04-15
Meeting the Potential Emergency Global Drug Supply Challenge of Hydroxychloroquine for COVID-19. The capacity and capabilities of global producers to meet the potential demand for treating patients inflicted with COVID-19 by the novel corona virus SARS-CoV-2, should HCQ’s efficacy be established by more definitive clinical trials, is also assessed. 2020-04-15
Hypertension, the renin-angiotensin system, and` the risk of lower respiratory tract infections and lung injury: implications for COVID-19. We also review in detail the molecular mechanisms linking the RAS to lung damage and the potential clinical impact of treatment with RAS blockers in patients with COVID-19 and a high cardiovascular and renal risk. 2020-04-15
[At least 68 vaccine candidates under development]. Whilst it usually takes 10-15 years to develop a vaccine, it has only taken just over 9 weeks from the publication of the viral genetic sequence for the first vaccine candidate to reach clinical testing. […] Development has been expediated by using existing technological platforms and by performing preclinical and clinical testing simultaneously. 2020-04-16
[Palliation in patients with severe COVID-19]. Coronavirus Disease 2019 (COVID-19) can cause severe respiratory failure and distressing symptoms including fever, cough, breathlessness and anxiety. 2020-04-16
On the alert for cytokine storm: Immunopathology in COVID-19. Most patients have mild to moderate symptoms, but a subgroup will become severely ill. 2020-04-15
Rapid Detection of COVID-19 Causative Virus (SARS-CoV-2) in Human Nasopharyngeal Swab Specimens Using Field-Effect Transistor-Based Biosensor. Here, we report a field-effect transistor (FET)-based biosensing device for detecting SARS-CoV-2 in clinical samples. […] Our FET device could detect SARS-CoV-2 spike protein at concentrations of 1 fg/ml in PBS and 100 fg/ml clinical transport medium. […] In addition, the FET sensor successfully detected SARS-CoV-2 in culture medium (limit of detection [LOD]: 1.6 x 101 pfu/ml) and clinical samples (LOD: 2.42 x 102 copies/ml). 2020-04-15
The Impact of the COVID-19 Pandemic on the Radiology Research Enterprise: Radiology Scientific Expert Panel. The current COVID-19 crisis continues to grow and has resulted in marked changes to clinical operations. […] In parallel with clinical preparedness, universities have shut down the majority of scientific research activities. 2020-04-15
Could HIV infection alter the clinical course of SARS-CoV-2 infection? When less is better. With this letter, we proposed a hypothesis that could explain the interaction between HIV infection and the clinical course of SARS-CoV-2 infection. 2020-04-15
Treatment with convalescent plasma for COVID-19 patients in Wuhan, China. A handful of literatures have summarized its clinical and radiologic features, whereas therapies for COVID-19 are rather limited. […] The efficacy of this intervention was determined by the alleviation of symptoms, changes in radiologic abnormalities and laboratory tests. 2020-04-15
Concomitant neurological symptoms observed in a patient diagnosed with coronavirus disease 2019. In clinical practice, not only fever and respiratory tract symptoms but also multiple organ symptoms are observed in patients diagnosed with COVID-19. […] Herein, we report a rare case of a patient diagnosed with COVID-19 who manifested with concomitant neurological symptoms. […] The patient developed fever and respiratory symptoms at disease onset, followed by muscle soreness, and subsequently altered consciousness and psychiatric symptoms, with positive signs based on neurological examination. […] This rare case indicates that SARS-CoV-2 can invade the central nervous system, thus causing neurological symptoms and signs. 2020-04-15
Clinical characteristics of 3,062 COVID-19 patients: a meta-analysis. We aim to systematically review the clinical characteristics of Coronavirus disease 2019 (COVID-19). […] Seven datebases were searched to collect studies about the clinical characteristics of COVID-19 from 1 January 2020 to 28 February 2020. […] Fever (80.4%), fatigue (46%), cough (63.1%) and expectoration (41.8%) were the most common clinical manifestations. […] Other common symptoms included muscle soreness (33%), anorexia (38.8%), chest tightness (35.7%), shortness of breath (35%), dyspnea (33.9%). […] Minor symptoms included nausea and vomiting (10.2%), diarrhea (12.9%), headache (15.4%), pharyngalgia(13.1%), shivering (10.9%) and abdominal pain (4.4%). […] The most commonly experienced symptoms of COVID-19 patients were fever, fatigue, cough and expectoration. 2020-04-15
Analysis of 92 deceased patients with COVID-19. This retrospective study aimed to analysis the clinical characteristics and complications in death cases with novel coronavirus disease-19 (COVID-19). […] We collected the medical records of 92 patients with COVID-19 in Renmin Hospital of Wuhan University who died during January 6th to February 25th, 2020, summarized the clinical characteristics of complications. 2020-04-15
Systematic review of the efficacy and safety of antiretroviral drugs against SARS, MERS or COVID-19: initial assessment. We systematically reviewed the clinical outcomes of using antiretroviral drugs for the prevention and treatment of coronaviruses and planned clinical trials. […] Three databases were screened from inception to 30 March 2020 for studies reporting clinical outcomes of patients with SARS, MERS or COVID-19 treated with antiretrovirals. […] From an initial screen of 433 titles, two randomized trials and 24 observational studies provided clinical outcome data on the use of antiretroviral drugs; most studies reported outcomes using LPV/r as treatment. […] In one randomized trial 99 patients with severe COVID-19 illness were randomized to receive LPV/r (400/100 mg twice a day) and 100 patients to standard of care for 14 days: LPV/r was not associated with a statistically significant difference in time to clinical improvement, although LPV/r given within 12 days of symptoms was associated with shorter time to clinical improvement; 28 day mortality was numerically lower in the LPV/r group (14/99) compared to the control group (25/100), but this difference was not statistically significant. […] On the basis of the available evidence it is uncertain whether LPV/r and other antiretrovirals improve clinical outcomes or prevent infection among patients at high risk of acquiring COVID-19. 2020-04-16
Rehabilitation and respiratory management in the acute and early post-acute phase. “Instant paper from the field” on rehabilitation answers to the Covid-19 emergency. In this paper we share the early experiences from the clinical field in Northern Italy, where the epidemic started in February. 2020-04-15
Coronaviruses and SARS-CoV-2. Seven coronavirus species are known to cause human infection, four of which, HCoV 229E, HCoV NL63, HCoV HKU1 and HCoV OC43, typically cause cold symptoms in immunocompetent individuals. 2020-04-15
ANTIVIRAL TREATMENT OF COVID-19. There have been more than 300 clinical trials going on, various antiviral and immunomodulating agents are in various stages of evaluation for COVID-19 in those trials and some of them will be published in the next couple of months. 2020-04-15
The Science Underlying COVID-19: Implications for the Cardiovascular System. Patients have diverse clinical outcomes, but those with pre-existing cardiovascular (CV) disease, hypertension, and related conditions incur disproportionately worse outcome. […] The tissue localization of the receptors correlates with COVDI-19 presenting symptoms and organ dysfunction. 2020-04-15
Triplex Real-Time RT-PCR for Severe Acute Respiratory Syndrome Coronavirus 2. We developed a triplex, real-time reverse transcription PCR for SARS-CoV-2 that maintained clinical performance compared with singleplex assays. 2020-04-15
Coronavirus infections and type 2 diabetes-shared pathways with therapeutic implications. Here we review the basic and clinical science spanning the intersections of diabetes, coronavirus infections, ACE2, and DPP4 biology, highlighting clinical relevance and evolving areas of uncertainty underlying the pathophysiology and treatment of T2D in the context of coronavirus infection. 2020-04-15
Cutaneous manifestations in COVID-19: a new contribution. In a recent review on clinical characteristics of coronavirus disease 2019 in China, rash was observed in 0,2% of cases2 . 2020-04-15
Viral exanthem in COVID-19, a clinical enigma with biological significance. Current researches emphasize on understanding of transmission patterns, severity, clinical features, and risk factors for infection, but the data remain limited. 2020-04-15
COVID-19 and Cutaneous manifestations. Recalcati noted that 20.4 % of the patients have cutaneous problem and mentioned that this is the first report on this clinical aspect of COVID-19. 2020-04-15
Urticarial eruption in COVID-19 infection. Many clinical manifestations of this virus are described and new symptoms are emerging particularly outside respiratory sphere, such as anosmia and ageusia which are recent ORL published symptoms. 2020-04-15
Liver impairment associated with disease progression in COVID-19 patients. The authors found that abnormalities of liver function tests are common in COVID-19 patients, but the clinically significant liver dysfunction in COVID-19 was not a prominent feature of this illness and also may not have serious clinical consequences. 2020-04-15
The Impact of COVID-19 on Bariatric Surgery: Re-Defining Psychosocial Care. Due to this pandemic, the rapid integration of virtual psychosocial care in bariatric surgery programs to address patients’ needs will create new opportunities for clinical and implementation science research. 2020-04-15
Risk factors for severity and mortality in adult COVID-19 inpatients in Wuhan. Data on the clinical characteristics and outcomes of patients with severe COVID-19 are limited. 2020-04-15
Clinical Features and Outcomes of Pregnant Women Suspected of Coronavirus Disease 2019. This study aims to observe the clinical features and outcomes of pregnant women who have been confirmed with COVID-19. […] These cases were subjected to pulmonary CT scan and routine blood test, manifested symptoms of fever, cough, chest tightness or gastrointestinal symptoms. […] They were admitted to an isolated suite, with clinical features and newborn babies being carefully observed. […] The clinical symptoms and laboratory indicators are not obvious for asymptomatic and mild COVID-19 pregnant women. 2020-04-15
CT imaging and clinical course of asymptomatic cases with COVID-19 pneumonia at admission in Wuhan, China. Aimed to characterize the CT imaging and clinical course of asymptomatic cases with COVID-19 pneumonia. […] The characteristics of CT imaging and clinical feature were collected and analyzed. 58 asymptomatic cases with COVID-19 pneumonia admitted to our hospital between Jan 1, 2020 and Feb 23, 2020 were enrolled. […] On admission, patients had no symptoms and laboratory findings were normal. […] After short-term follow-up, 16 patients (27.6%) presented symptoms with lower lymphocyte count and higher CRP, mainly including fever, cough and fatigue. 2020-04-15
Safety at the Time of the COVID-19 Pandemic: How to Keep our Oncology Patients and Healthcare Workers Safe. Undoubtedly, healthcare providers have had to rapidly alter care delivery models while simultaneously acknowledging the crucial unknowns of how these changes may affect clinical outcomes. 2020-04-15
Translating transmissibility measures into recommendations for coronavirus prevention. The rapid increase in clinical cases of the new coronavirus disease, COVID-19, suggests high transmissibility. 2020-04-15
Personality differences and COVID-19: are extroversion and conscientiousness personality traits associated with engagement with containment measures? The sample consisted of 715 Brazilian adults aged 18-78 years, who answered the Big Five Inventory 2 Short (BFI-2-S) and factors from the Dimensional Clinical Personality Inventory 2 (IDCP-2). 2020-04-15
A Clinical Study of Noninvasive Assessment of Lung Lesions in Patients with Coronavirus Disease-19 (COVID-19) by Bedside Ultrasound. This study was conducted to explore the clinical value of noninvasive assessment of bedside ultrasound in the diagnosis of lung lesions of Coronavirus Disease-19. […] The clinical value of ultrasound in the noninvasive assessment of lung lesions was evaluated. […] Bedside ultrasound has important clinical significance for noninvasive assessment and dynamic observation of lung lesions in patients with Coronavirus Disease-19, which is worth further consideration. 2020-04-15
Hydroxychloroquine use during the COVID-19 pandemic 2020. At present, there are no studies demonstrating the clinical efficacy of hydroxychloroquine for the prophylaxis or treatment of COVID-19 infection. 2020-04-15
ANZICS guiding principles for complex decision making during the COVID-19 pandemic. The global 2019 coronavirus disease (COVID-19) pandemic has led to major challenges in clinical decision making when the demand for intensive care exceeds local capacity. 2020-04-16
[Recommendations for respiratory rehabilitation of coronavirus disease 2019 in adult]. COVID-19 is a highly infectious respiratory infection disease, which leads to dysfunction of respiratory, physical, and psychological of the patients. pulmonary rehabilitation is an important intervention for clinical patients as well as cure patients. […] With the deeper cognition of COVID-19 and accumulation of clinical experience, we proposed the recommendations for pulmonary rehabilitation of COVID-19 in adults based on the opinions of front-line clinical experts involved in the management of this epidemic and a review of the relevant literature and evidences: (1)for the inpatients with COVID-19, pulmonary rehabilitation would relieve the symptoms of dyspnea, anxiety, and depression; eventually improve physical function and the quality of life; (2)For severe/critical inpatients, the early performance of pulmonary rehabilitation is not suggested. […] These recommendations can serve as a clinical practice guidence and basis for pulmonary rehabilitation of COVID-19. 2020-04-17
[Bronchoalveolar lavage fluid was used to diagnose two cases of 2019-nCoV infection]. The case reports 2 cases of novel coronavirus pneumonia diagnosed by concurrent bronchoalveolar lavage in our hospital, 1 case had a history of epidemiology, clinical symptoms and high imaging suspicion, but repeated negative throat swabs. […] Before the patient was discharged, the clinical symptoms disappeared, the chest CT showed significant improvement, and the pharynx swab was twice negative, reaching the discharge standard.We detected the ORF 1ab gene, the N gene and the nucleic acid of the new coronavirus in the broncho-alveolar lavage fluid of 2 patients. 2020-04-17
[What we learned from SARS may provide important insights into understanding and management of coronavirus disease 2019]. The experience and knowledge we gained from severe acute respiratory syndrome (SARS), especially with regard to the time course of viral replication, host immune response and clinical progression of the patient, may provide important insights into understanding and management of COVID-19. […] Clinical deterioration accompanied by decreasing viral load in the second week after symptom onset was noted both in SARS and COVID-19, suggesting that the lung damage at this phase is more related to excessive host immune response rather than uncontrolled viral replication. 2020-04-17
[CT imaging analysis of 33 cases with the 2019 novel coronavirus infection]. There were 3 cases of mild type, 27 cases of common type and 3 cases of severe type.There were 2 cases with hypertension, 1 case with postoperative lung,1 case with diabetes, 1 case with chronic bronchitis, and 1 case with bronchiectasis.SPSS25.0 Chi-square test was used to analyze the distribution of lesions in each lung lobe; SPSS25.0 Spearman correlation coefficient was used to analyze the image score and clinical classification. Results: There were 3 cases (9.1%) with normal lung and 30 cases (90.9%) with Novel Coronavirus Pneumonia(COVID-19) of the 2019-nCoV infected patients. […] The correlation coefficient between the degree of lesion distribution and clinical classification was 0.819, and the two were highly correlated.There were 30 cases (90.9%) with subpleural lesions, 17 cases (51.5%) with central lesions. 2020-04-17
What Does Plant-Based Vaccine Technology Offer to the Fight against COVID-19? Plant-based vaccines are a technology with proven viability, which have led to promising results for candidates evaluated at the clinical level, meaning this technology could contribute towards the fight against COVID-19. 2020-04-16
Coronavirus Diseases (COVID-19) Current Status and Future Perspectives: A Narrative Review. In particular, we focus on public health impact, pathophysiology and clinical manifestations, diagnosis, case management, emergency response and preparedness. 2020-04-21
[Clinical analysis of 150 cases of 2019 novel coronavirus infection in Nanyang City, Henan Province]. Objective: To analyze the epidemiological characteristics and clinical features of the patients with 2019-nCoV infection in Nanyang City, so as to provide evidence for clinical diagnosis and treatment. Methods: The epidemiology, clinical symptoms, atory and radiologic data of 150 patients with 2019-nCoV infection admitted to the designated hospitals in Nanyang City from January 24,2020 to February 16, 2020 were retrospectively analyzed. Results: The 150 patients with 2019 nCov infection consisted of 67 men and 83 women, and the median age was 45±16 years; 69 of them were the first generation case,60 of them were the second generation case, 6 of them were the third generation case,the median incubation period of the first generation case was 5.4±2.2 days, and the second generation case was 6.7±3.1 days, and the first-generation cases are the majority in severe patients (69%) . […] The most common basic disease was hypertension (13 cases, 9%), diabetes (9 cases, 6%), and the most common symptom is fever(142 cases, 95%, 63% showed moderate fever) , cough and sputum(108 cases,72%), fatigue(23 cases,15%), anorexia(20 cases, 13%), headache, diarrhea, muscle soreness, sore throat as the first symptoms. […] The average time from onset of symptoms to consultation was 4.2±2.2 days for all patients. […] After active treatment, 45% of patients were discharged according to discharge standards. 33% of sever and critically ill patients were discharged, 49% of them were degraded hospitalization.The average length of hospitalization was 12±4 days. Conclusion: A history of epidemiological exposure, fever, chest CT with signs of pneumonia, normal or decreased WBC, and lymphocytopenia, eosinophilia are the clinical basis for the diagnosis of this disease, and most of the sever patients were the first generation cases. 2020-04-16
[Screening for novel coronavirus related conjunctivitis among the patients with corona virus disease-19]. Eighty-one patients diagnosed as coronavirus disease-19 in Guangxi Zhuang Autonomous Region People’s Hospital were enrolled with ophthalmological consultation screening for novel coronavirus related conjunctivitis, including the inquiring of eye symptoms and checking for conjunctivitis-related signs. […] Conjunctival swab novel coronavirus nucleic acid test was performed on patients with clinical manifestation of conjunctivitis. Results: Only 3 of the 81 patients (3.70%) complained of eye discomfort, which appeared on the day 16.67±9.29 after the diagnosis of coronavirus disease-19. […] Screening of clinical symptoms and signs of conjunctivitis in the remaining 78 patients showed no significant abnormalities. Conclusions: There wasn’t any novel coronavirus related conjunctivitis in 81 patients with coronavirus disease-19.(Chin J Ophthalmol, 2020, 56:). 目的: 探讨新型冠状病毒肺炎(COVID-19)患者新型冠状病毒相关性结膜炎的患病情况。 2020-04-16
Oculoplastic surgery practice during the COVID-19 novel coronavirus pandemic: experience sharing from Hong Kong. Three main aspects are discussed, namely clinical, administrative, and training and educational. 2020-04-16
Investigating the Determinants of High Case-Fatality Rate for Coronavirus Disease 2019 in Italy. In particular, the majority of patients that are currently tested in Italy have severe clinical symptoms that usually require hospitalization and this translates to a large CFR. 2020-04-30
Allocation of Scarce Resources in a Pandemic: A Systematic Review of US State Crisis Standards of Care Documents. Finally, 28 had evidence-based clinical processes and operations. 2020-05-07
EMA advice on renin-angiotensin system medicines during covid-19 pandemic. Every month, DTB scans sources of information on treatments, disease management and other healthcare topics for key items to bring to our readers’ attention and help them keep up to date. 2020-05-28
COVID-19 and spinal cord injury and disease: results of an international survey. Of respondents who worked at an inpatient facility, 53.3% reported that only individuals with symptoms were being screened and 29.9% said that no screening was occurring. 2020-04-20
[SARS-CoV-2 infection may result in appendicular syndrome: Chest CT scan before appendectomy]. The initial clinical presentation of CoronaVirus Disease 2019 may be appendicular syndrome. 2020-05-07
Extracorporeal Membrane Oxygenation for Severe Respiratory Failure During Respiratory Epidemics and Pandemics: A Narrative Review. We discuss important ethical considerations and predictive scoring systems that may assist clinical decision-making to optimise resource allocation. 2020-05-18
Importance of inclusion of pregnant and breastfeeding women in COVID-19 therapeutic trials. Investigators are employing unprecedented innovation in the design of clinical trials to rapidly and rigorously assess potentially promising therapies for COVID-19; this is in stark contrast to the continued near universal regressive practice of exclusion of pregnant and breastfeeding women from these trials. 2020-04-30
A Tool to Early Predict Severe Corona Virus Disease 2019 (COVID-19) : A Multicenter Study using the Risk Nomogram in Wuhan and Guangdong, China. Decision curve and clinical impact curve analysis indicated that nomogram conferred high clinical net benefit. 2020-04-30
Nuclear medicine in responding to global pandemic COVID-19-American College of Nuclear Medicine member experience. Here, we summarize our American College of Nuclear Medicine members’ experiences from Wuhan, China; Singapore; and the USA, so to provide advice to the nuclear medicine personnel for their clinical practice and management strategies in responding to COVID-19. 2020-05-28
[Urology in the corona-virus pandemic-a guideline 4/20]. Furthermore strictly defined hygiene measures to protect employees in various clinical scenarios should be set up. 2020-04-20
Mechanism of thrombocytopenia in COVID-19 patients. We propose several mechanisms by which coronavirus disease 2019 causes thrombocytopenia to better understand this disease and provide more clinical treatment options. 2020-05-22
The role of imaging in 2019 novel coronavirus pneumonia (COVID-19). Currently, the 2019 novel coronavirus (SARS-CoV-2) can be identified by virus isolation or viral nucleic acid detection; however, false negatives associated with the nucleic acid detection provide a clinical challenge and thus make the imaging examination crucial. […] Imaging exams have been a main clinical diagnostic criteria for the 2019 novel coronavirus disease (COVID-19) in China. […] • Imaging examination has become the indispensable means not only in the early detection and diagnosis but also in monitoring the clinical course, evaluating the disease severity, and may be presented as an important warning signal preceding the negative RT-PCR test results. 2020-04-30
Association between platelet parameters and mortality in coronavirus disease 2019: Retrospective cohort study. The clinical and laboratory data of 383 patients with the definite outcome by March 1, 2020 in the Central Hospital of Wuhan were reviewed. 2020-05-22
Calculated Decisions: Brescia-COVID Respiratory Severity Scale (BCRSS)/Algorithm. The Brescia-COVID respiratory severity scale/algorithm is a stepwise management approach to COVID-19 patients based on clinical severity. […] The scale simplifies the clinical summary of a patient’s status, and allows clinicians to compare patients to one another and to track the trend of a patient’s level of respiratory severity over time. 2020-04-20
Correlation Between Relative Nasopharyngeal Virus RNA Load and Lymphocyte Count Disease Severity in Patients with COVID-19. The correlation between the relative load of nasopharyngeal SARS-CoV-2 RNA and severe disease symptoms was analyzed. 2020-04-16
Failure in initial stage containment of global COVID-19 epicenters. Based on our data, disease management in the 2 weeks following the first reported cases is of utmost importance. 2020-04-28
COVID-19: Recommended sampling sites at different stage of the disease. At present, it mainly relies on Real-time RT-PCR to detect SARS-CoV-2 virus nucleic acid collected from the clinical specimens of patients as the standard for diagnosis, discontinuation of quarantine and discharge.1,2 This article is protected by copyright. 2020-04-27
Evaluation of Antiviral Therapies for Coronavirus Disease 2019 (COVID-19) Pneumonia in Shanghai, China. Information including age, gender and duration from illness onset to admission, clinical manifestations and laboratory data at admission, and length of hospital stay were evaluated. […] The clinical symptoms and laboratory tests at discharge were also assessed. […] At admission, no significant differences were found among the groups, including duration from illness onset to admission, clinical symptoms and main laboratory results. […] At discharge, 7/184 (4%) patients had a mild cough while their other symptoms had disappeared, and the proportion of patients with abnormal liver function and with increased leucocytes, neutrophils or erythrocyte sedimentation rate among the 184 patients were close to those at admission. […] In addition, the results of chest CT imaging, clinical manifestations, and laboratory tests at discharge were not completely consistent. 2020-04-16
Virological and clinical cure in COVID-19 patients treated with hydroxychloroquine: A systematic review and meta-analysis. Following the demonstration of the efficacy of hydroxychloroquine against severe acute respiratory syndrome coronavirus 2 in vitro, many trials started to evaluate its efficacy in clinical settings. […] We conducted a systematic review and meta-analysis with the objectives of evaluation of safety and efficacy of HCQ alone or in combination in terms of “time to clinical cure,” “virological cure,” “death or clinical worsening of disease,” “radiological progression,” and safety. […] In terms of clinical cure, two studies reported possible benefit in “time to body temperature normalization” and one study reported less “cough days” in the HCQ arm. […] No difference was observed in virological cure (OR, 2.37, 95% CI, 0.13-44.53), death or clinical worsening of disease (OR, 1.37, 95% CI, 1.37-21.97), and safety (OR, 2.19, 95% CI, 0.59-8.18), when compared with the control/conventional treatment. 2020-05-03
High IL-6/IFN-γ ratio could be associated with severe disease in COVID-19 patients. In this study, a meta-analysis was performed to investigate whether the IL-6/IFN-γ ratio can help predict clinical severity in patients with COVID-19. 2020-04-28
How to Guarantee the Best of Care to Patients with Cancer During the COVID-19 Epidemic: The Italian Experience. In this context, in Italy, we reorganized the National Health System and prioritized the clinical cancer care scenario, balancing risk of SARS-CoV-2 transmission versus the magnitude of clinical benefit deriving from a specific therapeutic approach. 2020-04-27
Framework for prioritizing head and neck surgery during the COVID-19 pandemic. Finally, we discuss our preoperative clinical pathway for transmission mitigation including defining low-risk and high-risk surgery for transmission and role of preoperative COVID-19 testing. 2020-05-29
Hospital Preparedness for COVID-19: A Practical Guide from a Critical Care Perspective. Multiple areas of surge planning progressed, simultaneously focused on infection control, clinical operational challenges, ICU surge capacity, staffing, ethics, and maintenance of staff wellness. […] The protocols developed focused on clinical decisions regarding intubation, the use of high-flow oxygen, engagement with infectious disease consultants, and cardiac arrest. […] Support was provided for both clinical and nonclinical staff affected by the profound impact COVID-19 had on our city. 2020-05-29
Characteristics of Health Care Personnel with COVID-19 - United States, February 12-April 9, 2020. Although 4,336 (92%) HCP patients reported having at least one symptom among fever, cough, or shortness of breath, the remaining 8% did not report any of these symptoms. 2020-04-17
Transmission of COVID-19 to Health Care Personnel During Exposures to a Hospitalized Patient - Solano County, California, February 2020. Among 121 hospital A health care personnel (HCP) who were exposed to the patient, 43 (35.5%) developed symptoms during the 14 days after exposure and were tested for SARS-CoV-2; three had positive test results and were among the first known cases of probable occupational transmission of SARS-CoV-2 to HCP in the United States. 2020-04-17
Hospitalization Rates and Characteristics of Patients Hospitalized with Laboratory-Confirmed Coronavirus Disease 2019 - COVID-NET, 14 States, March 1-30, 2020. This report presents age-stratified COVID-19-associated hospitalization rates for patients admitted during March 1-28, 2020, and clinical data on patients admitted during March 1-30, 2020, the first month of U.S. surveillance. […] In addition, older adults and persons with serious underlying medical conditions should avoid contact with persons who are ill and immediately contact their health care provider(s) if they have symptoms consistent with COVID-19 ( (5). […] Ongoing monitoring of hospitalization rates, clinical characteristics, and outcomes of hospitalized patients will be important to better understand the evolving epidemiology of COVID-19 in the United States and the clinical spectrum of disease, and to help guide planning and prioritization of health care system resources. 2020-04-16
The SARS-CoV-2 receptor ACE2 expression of maternal-fetal interface and fetal organs by single-cell transcriptome study. And thus, both the vertical transmission and the placenta dysfunction/abortion caused by SARS-CoV-2 need to be further carefully investigated in clinical practice. 2020-04-22
Clinical Best Practice Advice for Hepatology and Liver Transplant Providers During the COVID-19 Pandemic: AASLD Expert Panel Consensus Statement. Our aim is to provide a template for the development of clinical recommendations and policies to mitigate the impact of the COVID-19 pandemic on liver patients and healthcare providers. 2020-04-16
Management of infantile hemangiomas during the COVID pandemic. FDA/EMA-approved monitoring guidelines, clinical practice guidelines, and relevant, up-to-date publications regarding initiation and monitoring of beta-blocker therapy were used to inform the recommendations. […] Clinical decision-making guidelines about when telehealth is an appropriate alternative to in-office visits, including medication initiation, dosage changes, and ongoing evaluation, are included. 2020-05-16
Operational Strategies to Prevent Coronavirus Disease 2019 (COVID-19) Spread in Radiology: Experience From a Singapore Radiology Department After Severe Acute Respiratory Syndrome. In this article, the authors share several operational guidelines and strategies implemented in our practice to reduce spread of COVID-19 and maintain clinical and educational needs of a teaching hospital. 2020-04-29
Saliva is a reliable tool to detect SARS-CoV-2. This study analyzed salivary samples of COVID-19 patients and compared the results with their clinical and laboratory data. […] Prevalence of positivity in saliva and association between clinical data and the cycle threshold as a semiquantitative indicator of viral load were considered. […] The role of saliva in COVID-19 diagnosis could not be limited to a qualitative detection of the virus, but it may also provide information about the clinical evolution of the disease. 2020-05-05
Teleurology in the Time of Covid-19 Pandemic: Here to Stay? All the outpatient clinical activities during the 4 weeks following the national lockdown (March 9-April 3, 2020) in the Department of Urology of the Trento Province, Italy, were reviewed and categorized. […] Seventy-four percent of face-to-face visits regarded suspected recurrent or new onset malignancy or potentially dangerous clinical conditions (severe urinary symptoms or complicated urinary stones or infection). 2020-05-29
Successful treatment of plasma exchange followed by intravenous immunogloblin in a critically ill patient with 2019 novel coronavirus infection. The patient avoided mechanical ventilation and acquired an immediate clinical and radiological improvement, after treatment of intensive plasma exchange (PE) followed by intravenous immunogloblin (IVIG). […] What’s more, it may improve poor clinical outcomes of these patients. 2020-05-05
COVID-19: Abnormal liver function tests. We evaluated the clinical characteristics of COVID-19 in patients with abnormal liver test results. […] Clinical records and laboratory results were obtained from 417 patients with laboratory-confirmed COVID-19 who were admitted to the only referral hospital in Shenzhen, China from January 11 to February 21, 2020 and followed up to March 7, 2020. […] Information on clinical features of patients with abnormal liver tests were collected for analysis. 2020-05-05
The COVID-19 pandemic will have a long-lasting impact on the quality of cirrhosis care. This includes an intensification of the preventative care provided to patients with compensated cirrhosis, proactive chronic disease management, robust telehealth programs, and a reorganization of care delivery to provide a full service of care with flexible clinical staffing. 2020-05-05
A longitudinal study on the mental health of general population during the COVID-19 epidemic in China. This longitudinal study surveyed the general population twice - during the initial outbreak, and the epidemic’s peak four weeks later, surveying demographics, symptoms, knowledge, concerns, and precautionary measures against COVID-19. […] IES-R measures PTSD symptoms in survivorship after an event. […] Nevertheless, the mean IES-R score of the first- and second-survey respondents were above the cut-off scores (>24) for PTSD symptoms, suggesting that the reduction in scores was not clinically significant. 2020-04-19
Are we facing a crashing wave of neuropsychiatric sequelae of COVID-19? Neuropsychiatric symptoms and potential immunologic mechanisms. Past pandemics have demonstrated that diverse types of neuropsychiatric symptoms, such as encephalopathy, mood changes, psychosis, neuromuscular dysfunction, or demyelinating processes, may accompany acute viral infection, or may follow infection by weeks, months, or longer in recovered patients. 2020-04-24
Clinical characteristics of 225 patients with COVID-19 in a tertiary Hospital near Wuhan, China. There is a need to study the clinical features of patients in a hospital near Wuhan. […] To identify clinical features of patients with COVID-19 in a tertiary hospital near Wuhan. […] General information, clinical manifestations, laboratory data, and computed tomography (CT) data were collected for 225 patients diagnosed of COVID-19 admitted between January 20 and February 14, 2020, to the Hanchuan City People’s Hospital. […] The major clinical symptoms were fever (84.44% of patients), cough (56.44% of patients), and dyspnea (4.00% of patients); 3.56%-22.67% of subjects suffered from expectoration, fatigue, chills, headache, chest pain, and pharyngalgia. […] Clinical characteristics of COVID-19 patients in the tertiary hospital near Wuhan are very similar to those found in Wuhan, but the lower mortality. 2020-05-27
Central nervous system manifestations of COVID-19: A systematic review. Precise and targeted documentation of neurological symptoms, detailed clinical, neurological, and electrophysiological investigations of the patients, attempts to isolate SARS-CoV-2 from cerebrospinal fluid, and autopsies of the COVID-19 victims may clarify the role played by this virus in causing neurological manifestations. 2020-05-27
Radiological approaches to COVID-19 pneumonia The symptoms are undiagnostic, the results of viral nucleic acid detection method (PCR) can delay, so that chest computerized tomography is often key diagnostic test in patients with possible COVID-19 pneumonia. 2020-04-22
Protective measures for COVID-19 for healthcare providers and laboratory personnel Therefore, how to ensure the triage of the patient with acute respiratory symptoms should be determined in advance, the contact distance should be arranged to be at least 2 m, COVID-19 suspect or diagnosed patient should be instructed to wear a surgical mask. 2020-04-22
Epidemiology of COVID-19 Last human coronavirus which emerged world from Wuhan China, SARS CoV-2 and its clinical expression, Coronavirus disease (COVID-19) recently taken a significant place in our daily practice. 2020-04-22
Coronavirus Anxiety Scale: A brief mental health screener for COVID-19 related anxiety. These results support the CAS as an efficient and valid tool for clinical research and practice. 2020-05-08
Should we expect neurological symptoms in the SARS-CoV-2 epidemic? Neurological symptoms were rarely reported in the SARS-CoV and MERS-CoV epidemics, although isolated cases were described. […] There are also reports of cases of neurological symptoms associated with CoV-OC43 and CoV-229E infection. […] Although neurological symptoms are not frequent in coronavirus epidemics, the high number of patients with SARS-CoV-2 infection may explain the presence of the virus in the CNS and increase the likelihood of early- or delayed-onset neurological symptoms. 2020-05-04
Cardiac Surgery in Canada During the COVID-19 Pandemic: A Guidance Statement From the Canadian Society of Cardiac Surgeons. At present, Canada has more than 8000 cases of COVID-19, with considerable variation in rates of infection among provinces and territories.3 Amid concerns over growing resource constraints, cardiac surgeons from across Canada have been forced to make drastic changes to their clinical practices. 2020-05-10
CRISPR-Cas12-based detection of SARS-CoV-2. We validated our method using contrived reference samples and clinical samples from patients in the United States, including 36 patients with COVID-19 infection and 42 patients with other viral respiratory infections. 2020-04-17
Can an effective SARS-CoV-2 vaccine be developed for the older population? While many younger people experience no or mild symptoms on infection, older adults are highly susceptible to life-threatening respiratory and systemic conditions which demand a full understanding and leveraging of knowledge of the differences between immunity in young and old people. 2020-04-20
Coronavirus Disease: A Review of a New Threat to Public Health. In December 2019, several patients from Wuhan, China were admitted to hospitals with symptoms of pneumonia. […] As the number of patients presenting with similar symptoms started to rise, the causative agent was eventually isolated from samples. 2020-04-20
Novel Coronavirus Disease (COVID-19) and Biologic Therapy in Psoriasis: Infection Risk and Patient Counseling in Uncertain Times. While there are currently no specific data for psoriasis biologics and COVID-19, data are presented here from phase III clinical trials of psoriasis biologics on rates of upper respiratory infection, influenza, and serious infection. 2020-05-16
Genomic characterization of a novel SARS-CoV-2. The finding heavily supports an intense requirement for additional prompt, inclusive investigations that combine genomic detail, epidemiological information and graph records of the clinical features of patients with COVID-19. 2020-04-21
A diagnostic model for coronavirus disease 2019 (COVID-19) based on radiological semantic and clinical features: a multi-center study. We aim to identify differences in CT imaging and clinical manifestations between pneumonia patients with and without COVID-19, and to develop and validate a diagnostic model for COVID-19 based on radiological semantic and clinical features alone. […] Three models were constructed using radiological semantic and clinical features through multivariate logistic regression. […] Clinical usage was evaluated by decision curve analysis and nomogram. […] Eighteen radiological semantic features and seventeen clinical features were identified to be significantly different. […] The clinical and radiological semantic models provided a better diagnostic performance and more considerable net benefits. […] Based on CT imaging and clinical manifestations alone, the pneumonia patients with and without COVID-19 can be distinguished. […] A model composed of radiological semantic and clinical features has an excellent performance for the diagnosis of COVID-19. […] • Based on CT imaging and clinical manifestations alone, the pneumonia patients with and without COVID-19 can be distinguished. […] • A diagnostic model for COVID-19 was developed and validated using radiological semantic and clinical features, which had an area under the curve value of 0.986 (95% CI 0.966~1.000) and 0.936 (95% CI 0.866~1.000) in the primary and validation cohorts, respectively. 2020-04-30
Clinical characteristics of COVID-19 in children compared with adults in Shandong Province, China. We reported on the epidemiological, clinical, laboratory, and radiological characteristics of children cases to help health workers better understand and provide timely diagnosis and treatment. […] Epidemiological, clinical, laboratory, and radiological characteristics of children and adults were analyzed and compared. […] Most cases in children were mild (21.4%) and conventional cases (78.6%), with mild clinical signs and symptoms, and all cases were of family clusters. […] Fever (35.7%) and dry cough (21.4%) were described as clinical manifestations in children cases. […] Dry cough and phlegm were not the most common symptoms in children compared with adults (p = 0.03). […] The clinical symptoms of children are mild, there is substantial lung injury even among children, but that there is less clinical disease, perhaps because of a less pronounced inflammatory response, and that the occurrence of this pattern appears to inversely correlate with age. 2020-05-29
COVID-19 in solid organ transplant recipients: A single-center case series from Spain. The clinical characteristics, management, and outcome of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) after solid organ transplant (SOT) remain unknown. […] After a median follow-up of 18 days from symptom onset, 30.8% (4/13) of survivors developed progressive respiratory failure, 7.7% (1/13) showed stable clinical condition or improvement, and 61.5% (8/13) had been discharged home. 2020-05-10
Case report: A kidney transplant patient with mild COVID-19. Here, we report the clinical features and our treatment approach for a kidney transplant patient with a diagnosis of COVID-19. 2020-05-22
‘Let us Help’-Why senior medical students are the next step in battling the COVID-19 Pandemic. With clinical placement and exams cancelled, we are determined to use our hard-earned skills in some way, to help in what is the biggest global emergency of our lifetime. 2020-05-07
Smell dysfunction: a biomarker for COVID-19. The symptoms presently recognized by the World Health Organization are cough, fever, tiredness, and difficulty breathing. 2020-04-17
Walk-Through Screening Center for COVID-19: an Accessible and Efficient Screening System in a Pandemic Situation. A walk-through (WT) screening center using negative pressure booths that is inspired by the biosafety cabinet has been designed and implemented in Korea for easy screening of COVID-19 and for safe and efficient consultation for patients with fever or respiratory symptoms. 2020-04-20
Attenuated SARS-CoV-2 variants with deletions at the S1/S2 junction. Examination of the original clinical specimen from which the isolate was derived, and 26 additional SARS-CoV-2 positive clinical specimens, failed to detect these variants. 2020-05-06
Assessment of the quality of systematic reviews on COVID-19: A comparative study of previous coronavirus outbreaks. Several systematic reviews (SRs) have been conducted on the COVID-19 outbreak, which together with the SRs on previous coronavirus outbreaks, form important sources of evidence for clinical decision and policy making. 2020-04-28
A review of initial data on pregnancy during the COVID-19 outbreak: implications for assisted reproductive treatments. While in most cases, mild symptoms are observed, in some cases the infection leads to serious pulmonary disease. […] Reported data suggest that symptoms in pregnant women are similar to those in other people, and that there is no evidence for higher maternal or fetal risks. 2020-04-28
Lung Base Findings of Coronavirus Disease (COVID-19) on Abdominal CT in Patients With Predominant Gastrointestinal Symptoms. OBJECTIVE. This series of patients presented to the emergency department (ED) with abdominal pain, without the respiratory symptoms typical of coronavirus disease (COVID-19), and the abdominal radiologist was the first to suggest COVID-19 infection because of findings in the lung bases on CT of the abdomen. CONCLUSION. COVID-19 infection can present primarily with abdominal symptoms, and the abdominal radiologist must suggest the diagnosis when evaluating the lung bases for typical findings. 2020-04-17
Well-aerated Lung on Admitting Chest CT to Predict Adverse Outcome in COVID-19 Pneumonia. Patients with negative reverse-transcription polymerase chain reaction (RT-PCR) for SARS-CoV-2 in nasal-pharyngeal swabs, negative chest CT, and incomplete clinical data were excluded. […] Clinical parameters included demographics, comorbidities, symptoms and symptom duration, oxygen saturation and laboratory values. […] Logistic regression was used to evaluate relationship between clinical parameters and CT metrics versus patient outcome (ICU admission/death vs. no ICU admission/ death). […] In comparison with clinical model containing only clinical parameters (AUC, 0.83), all three quantitative models showed higher diagnostic performance (AUC 0.86 for all models). […] The models containing %V-WAL<73% and VOL-WAL<2.9L were superior in terms of performance as compared to the models containing only clinical parameters (P=0.04 for both models). 2020-04-27
What do urologists need to know: Diagnosis, treatment, and follow-up during COVID-19 pandemic. While it affects the respiratory system causing symptoms ranging from fever, cough, dyspnea, diarrhea, nausea, myalgia and fatigue, it eventually causes pneumonia and respiratory distress needing oxygenation and ventilation. 2020-05-20
Routine blood tests as a potential diagnostic tool for COVID-19. In addition, the need of certified laboratories, expensive equipment and trained personnel led many countries to limit the rRT-PCR tests only to individuals with pronounced respiratory syndrome symptoms. […] Methods We analyzed the plasma levels of white blood cells (WBCs), platelets, C-reactive protein (CRP), aspartate aminotransferase (AST), alanine aminotransferase (ALT), γ-glutamyl transpeptidase (GGT), alkaline phosphatase and lactate dehydrogenase (LDH) of 207 patients who, after being admitted to the emergency room of the San Raffaele Hospital (Milan, Italy) with COVID-19 symptoms, were rRT-PCR tested. 2020-04-17
Analytical performances of a chemiluminescence immunoassay for SARS-CoV-2 IgM/IgG and antibody kinetics. The clinical spectrum of the disease varies from mild to severe acute respiratory distress syndrome (ARDS). […] Methods The imprecision of the MAGLUMI™ 2000 Plus 2019-nCov IgM and IgG assays (Snibe, Shenzhen, China) was assessed by adopting the Clinical and Laboratory Standards Institute (CLSI) EP15-A3 protocol. 2020-04-17
Digestive Symptoms in COVID-19 Patients With Mild Disease Severity: Clinical Presentation, Stool Viral RNA Testing, and Outcomes. Coronavirus disease 2019 (COVID-19) most commonly presents with respiratory symptoms, including cough, shortness of breath, and sore throat. […] However, digestive symptoms also occur in patients with COVID-19 and are often described in outpatients with less severe disease. […] In this study, we sought to describe the clinical characteristics of COVID-19 patients with digestive symptoms and mild disease severity. […] We identified COVID-19 patients with mild disease and one or more digestive symptoms (diarrhea, nausea, and vomiting), with or without respiratory symptoms, and compared them with a group presenting solely with respiratory symptoms. […] We then compared the clinical features between those with digestive symptoms and those with respiratory symptoms. […] There were 206 patients with low severity COVID-19, including 48 presenting with a digestive symptom alone, 69 with both digestive and respiratory symptoms, and 89 with respiratory symptoms alone. […] Between the 2 groups with digestive symptoms, 67 presented with diarrhea, of whom 19.4% experienced diarrhea as the first symptom in their illness course. […] Patients with digestive symptoms presented for care later than those with respiratory symptoms (16.0 ± 7.7 vs 11.6 ± 5.1 days, P < 0.001). […] Nevertheless, patients with digestive symptoms had a longer duration between symptom onset and viral clearance (P < 0.001) and were more likely to be fecal virus positive (73.3% vs 14.3%, P = 0.033) than those with respiratory symptoms. […] We describe a unique subgroup of COVID-19 patients with mild disease severity marked by the presence of digestive symptoms. […] These patients are more likely to test positive for viral RNA in stool, to have a longer delay before viral clearance, and to experience delayed diagnosis compared with patients with only respiratory symptoms. 2020-04-23
Neuroanesthesia Practice During the COVID-19 Pandemic: Recommendations from Society for Neuroscience in Anesthesiology & Critical Care (SNACC). This consensus statement provides information on the neurological manifestations of COVID-19, advice for neuroanesthesia clinical practice during emergent neurosurgery, interventional radiology (excluding endovascular treatment of acute ischemic stroke), transnasal neurosurgery, awake craniotomy and electroconvulsive therapy, as well as information about healthcare provider wellness. 2020-05-22
Cardiovascular Pharmacology in the Time of COVID-19: A Focus on Angiotensin Converting Enzyme 2. Pre-clinical models suggest that ACE2 upregulation confers protective effects in acute lung injury. […] We review current knowledge of the role of ACE2 in cardiovascular physiology and SARS-CoV-2 virology as well as clinical data to inform the management of patients with or at risk for COVID-19 who require renin-angiotensin-aldosterone system inhibitor therapy. 2020-05-16
Detectable serum SARS-CoV-2 viral load (RNAaemia) is closely correlated with drastically elevated interleukin 6 (IL-6) level in critically ill COVID-19 patients. The clinical and laboratory data were collected. […] Clinical characteristics analysis of 48 cases of COVID-19 showed that RNAaemia was diagnosed only in the critically ill group and seemed to reflect the severity of the disease. 2020-04-30
The duration of viral shedding of discharged patients with severe COVID-19. Most of studies paid attention to epidemiological, clinical, and radiological features of inpatients with COVID-191-3. […] However, little studies have focused on clinical characteristics of discharged patients with severe COVID-19, especially the duration of viral shedding. 2020-04-30
SARS-CoV-2 Seroconversion in Humans: A Detailed Protocol for a Serological Assay, Antigen Production, and Test Setup. These assays can be used for research studies and for testing in clinical laboratories. 2020-04-22
COVID-19 Transmission in Dental Practice: Brief Review of Preventive Measures in Italy. The documented clinical experience, the measures of professional prevention, and the actual Italian situation were reported and described. 2020-04-17
Brief Summary of Potential SARS-CoV-2 Prophylactic and Treatment Drugs in the Emergency Department. The National Institutes of Health is conducting a Phase 1 clinical trial to evaluate for a potential vaccine and the recipients have started to receive the investigational vaccine.2 We present a brief overview of the potential prophylactic and treatment agents under investigation, some which could be initiated in the ED if proven effective. 2020-05-21
Augmenting the Disaster Healthcare Workforce. Which non-clinical volunteers can we use and in what capacities? 2020-05-20
Targeting potential drivers of COVID-19: Neutrophil extracellular traps. If our hypothesis is correct, targeting NETs directly and/or indirectly with existing drugs may reduce the clinical severity of COVID-19. 2020-04-23
Clinical Pharmacology Perspectives on the Antiviral Activity of Azithromycin and Use in COVID-19. AZ is not approved for the treatment of viral infections, and there is no well-controlled, prospective, randomized clinical evidence to support AZ therapy in coronavirus disease 2019 (COVID-19). […] It is essential that the clinical pharmacology (CP) characteristics of AZ be considered in planning and conducting clinical trials of AZ alone or in combination with other agents, to ensure safe study conduct and to increase the probability of achieving definitive answers regarding efficacy of AZ in the treatment of COVID-19. […] The safety profile of AZ used as an antibacterial agent is well established.1 This work assesses published in vitro and clinical evidence for AZ as an agent with antiviral properties. […] It also provides basic CP information relevant for planning and initiating COVID-19 clinical studies with AZ, summarizes safety data from healthy volunteer studies, and safety and efficacy data from phase II and phase II/III studies in patients with uncomplicated malaria, including a phase II/III study in pediatric patients following administration of AZ and CQ in combination. 2020-05-12
Hypercoagulability of COVID-19 patients in Intensive Care Unit. A Report of Thromboelastography Findings and other Parameters of Hemostasis. Clinical trials are urgently needed to establish the type of drug, dosage and optimal duration of prophylaxis. 2020-04-17
The procoagulant pattern of patients with COVID-19 acute respiratory distress syndrome. Reports of thromboembolic complications are scarce but suggestive for a clinical relevance of the problem. […] The pro-coagulant pattern of these patients may justify the clinical reports of thromboembolic complications (pulmonary embolism) during the course of the disease. 2020-05-06
ISTH interim guidance on recognition and management of coagulopathy in COVID-19: A Comment. Patients that are critically ill with COVID-19 have hallmark signs of disseminated intravascular coagulation (DIC)(2), and as noted in the ISTH interim guidance and our own clinical practice, thrombosis is the overwhelming phenotype with rare bleeding complications. 2020-04-17
Physiological and pathological regulation of ACE2, the SARS-CoV-2 receptor. Moreover, accumulating evidence has demonstrated the implication of ACE2 in the pathological progression in tissue injury and several chronic diseases, ACE2 may also be essential in the progression and clinical outcomes of COVID-19. 2020-05-30
Clinical characteristics of 80 hospitalized frontline medical workers infected with COVID-19 in Wuhan, China. The most common symptoms at onset were fever (65, 81.25%), cough (47, 58.75%), fatigue (28, 35%), myalgia (19, 23.75%), expectoration (19, 23.75%), and diarrhea (15, 18.75%). […] Patients of frontline medical workers at a single-center hospital showed some unique clinical and laboratory findings compared with other patients in Wuhan and outside of Wuhan. 2020-05-03
Pulmonary embolism in patients with COVID-19: Time to change the paradigm of computed tomography. To raise awareness for possible benefits of examining known COVID-19 patients presenting sudden clinical worsening with CT pulmonary angiography instead of standard non-contrast chest CT. 2020-05-30
Psychological symptoms of ordinary Chinese citizens based on SCL-90 during the level I emergency response to COVID-19. This study aimed to investigate the psychological symptoms of ordinary Chinese citizens during the Level I Emergency Response throughout China. […] Based on a cut-off point of the GSI T-scores of 63, the overall sample was divided into high and low-risk groups. of the 1,060 participants investigated in China, more than 70% of them have moderate and higher level of psychological symptoms specifically elevated scores for obsessive compulsion, interpersonal sensitivity, phobic anxiety, and psychoticism. […] Those who were of over 50 years old, had an undergraduate education and below, were divorced or widowed, and agricultural workers had significantly more symptoms. 2020-05-19
When health professionals look death in the eye: the mental health of professionals who deal daily with the 2019 coronavirus outbreak. It has been associated with anxiety including multiple clinical activities, depression in the face of the coexistence of countless deaths, long work shifts with the most diverse unknowns and demands in the treatment with patients with COVID-19. 2020-05-19
Portable chest X-ray in coronavirus disease-19 (COVID-19): A pictorial review. Furthermore, in cases of high clinical suspicion for COVID-19, a positive CXR may obviate the need for CT. 2020-05-22
COVID-19 and mental health: A review of the existing literature. Preliminary evidence suggests that symptoms of anxiety and depression (16-28%) and self-reported stress (8%) are common psychological reactions to the COVID-19 pandemic, and may be associated with disturbed sleep. 2020-05-29
Epidemiologic and clinical characteristics of 10 children with coronavirus disease 2019 in Changsha, China. We report the epidemiological, clinical, laboratory, and high-resolution CT findings for these children. […] Clinical manifestations included fever in four cases, respiratory symptoms in three cases, febrile convulsions in one case, vomiting in one case, abdominal pain in one case, and asymptomatic infection in two cases. 2020-05-27
Epidemiological characteristics and clinical features of 32 critical and 67 noncritical cases of COVID-19 in Chengdu. The number of cases has increased rapidly, but information on the clinical characteristics remains limited. […] This paper describes the epidemiological and clinical characteristics of COVID-19. […] This study included a retrospective, single-center case series of 99 consecutively hospitalized patients with confirmed COVID-19 at Chengdu Public Health Clinical Medical Center in Chengdu, China, from January 16 to February 20, 2020. […] We collected and analyzed epidemiological, demographic, clinical, laboratory, radiological, and treatment data. […] Common symptoms included fever (85 [86 %]), dry cough (84 [85 %]), and fatigue (72 [73 %]). […] We analyzed the clinical characteristics of patients. 2020-05-27
Clinical characteristics and risk assessment of newborns born to mothers with COVID-19. Here, we report the clinical characteristics of the newborns delivered by SARS-CoV-2 infected pregnant women. […] We prospectively collected and analyzed the clinical features, laboratory data and outcomes of 7 newborns delivered by SARS-CoV-2 infected pregnant women in Zhongnan Hospital of Wuhan University during January 20 to January 29, 2020. 4 of the 7 newborns were late preterm with gestational age between 36 weeks and 37 weeks, and the other 3 were full-term infants. 2020-05-27
ESGE and ESGENA Position Statement on gastrointestinal endoscopy and the COVID-19 pandemic. The clinical manifestations of COVID-19 can be subtle, encompassing a broad spectrum from asymptomatic mild disease to severe respiratory illness. 2020-05-29
Two known therapies could be useful as adjuvant therapy in critical patients infected by COVID-19. Obviously clinical trials are necessaries, but due to the potential benefit of these two therapies we highly recommended to add to the therapeutic arsenal. 2020-05-21
Comparison of Abbott ID Now, Diasorin Simplexa, and CDC FDA EUA methods for the detection of SARS-CoV-2 from nasopharyngeal and nasal swabs from individuals diagnosed with COVID-19. Food & Drug Administration (FDA) for the detection of SARS-CoV-2, but little has been studied to determine how well these assays perform using clinical specimens. 2020-04-18
Comparative pathogenesis of COVID-19, MERS, and SARS in a nonhuman primate model. In SARS-CoV-2-infected macaques, virus was excreted from nose and throat in the absence of clinical signs and detected in type I and II pneumocytes in foci of diffuse alveolar damage and in ciliated epithelial cells of nasal, bronchial, and bronchiolar mucosae. 2020-05-31
British Society of Gastroenterology guidance for management of inflammatory bowel disease during the COVID-19 pandemic. In the UK, we have rapidly mobilised inflammatory bowel disease (IBD) centres in order that preparations can be made to protect our patients and the clinical services they rely on. […] Further considerations are given to service provision, medical and surgical therapy, endoscopy, imaging and clinical trials. 2020-05-13
Covid-19 and immunomodulation in IBD. Although covid-19 leads to little or mild flu-like symptoms in the majority of affected patients, the disease may cause severe, frequently lethal complications such as progressive pneumonia, acute respiratory distress syndrome and organ failure driven by hyperinflammation and a cytokine storm syndrome. 2020-05-14
Miller Fisher Syndrome and polyneuritis cranialis in COVID-19. Patient data were obtained from medical records from the University Hospital “Príncipe de Asturias”, Alcalá de Henares, Madrid, Spain and from the University Hospital “12 de Octubre”, Madrid, Spain. […] The full clinical spectrum of neurological symptoms in patients with COVID-19 remains to be characterized. 2020-04-18
COVID-19 tsunami: the first case of a spinal cord injury patient in Italy. One difference between this case and the known clinical course of COVID-19 is that did not develop cough. […] Another interesting feature of our case is that, despite tetraplegia, the clinical course was not severe. 2020-04-24
New onset acute symptomatic seizure and risk factors in coronavirus disease 2019: A retrospective multicenter study. Data were collected from medical records by 11 neurologists using a standard case report form. […] Two people had seizurelike symptoms during hospitalization due to acute stress reaction and hypocalcemia, and 84 (27%) had brain insults or metabolic imbalances during the disease course known to increase the risk of seizures. 2020-05-02
Novel coronavirus disease (COVID-19) in children The epidemiological and clinical patterns of COVID-19 and treatment approaches in pediatric patients still remain unclear although many pediatric reports are published. […] This review aims to summarize the current epidemics, clinical presentations, diagnosis, and treatment of COVID-19 in pediatric patients. 2020-04-22
COVID-19 Respiratory Failure: Targeting Inflammation on VV-ECMO Support. His clinical course involved rapid and profound respiratory decompensation such that he required support with venovenous extracorporeal membrane oxygenation (VV-ECMO). 2020-05-30
Orthopaedic Surgical Selection and Inpatient Paradigms During the Coronavirus (COVID-19) Pandemic. These areas affecting inpatient paradigms include surgical priority, physical or social distancing, file sharing for online clinical communications, and physician wellness. 2020-05-25
The performance of chest CT in evaluating the clinical severity of COVID-19 pneumonia: identifying critical cases based on CT characteristics. To assess the clinical severity of COVID-19 pneumonia using qualitative and/or quantitative chest CT indicators and identify the CT characteristics of critical cases. 2020-04-23
The Impact of the COVID-19 Pandemic on Cancer Patients. Currently, there is no specific treatment or approved vaccine against COVID-19 and many clinical trials are currently investigating potential medications to treat COVID-19. […] This short review aims to focus on the impact of COVID-19 on a cancer patient and discuss management options and recommendation in addition to highlighting the currently available clinical guidelines and resources. 2020-05-29
COVID-19 in children: Current status. Symptoms are usually less severe in children than in adults. […] Clinical physicians should be alert to asymptomatic children with COVID-19. 2020-05-19
Angiotensin receptor blockers and COVID-19. Controlled clinical studies should be conducted to determine whether ARBs may be included as additional therapy for COVID-19 patients. 2020-05-20
Risk Factors of Fatal Outcome in Hospitalized Subjects With Coronavirus Disease 2019 From a Nationwide Analysis in China. The prognostic effects of variables, including clinical features and laboratory findings, were analyzed by using Kaplan-Meier methods and a Cox proportional hazards model. […] The proposed nomogram accurately predicted clinical outcomes of patients with COVID-19 based on individual characteristics. 2020-05-28
COVID-19: Four Paediatric Cases in Malaysia. The children had no symptoms or mild flu-like illness. 2020-05-20
The diagnostic and predictive role of NLR, d-NLR and PLR in COVID-19 patients. Fever (83.8%) and cough (70.9%) were the two most common symptoms. […] The binary logistic analysis identified elevated NLR (hazard risk [HR] 2.46, 95% confidence interval [CI] 1.98-4.57) and age (HR 2.52, 95% CI 1.65-4.83) as independent factors for poor clinical outcome of COVID-19. […] Elevated age and NLR can be considered independent biomarkers for indicating poor clinical outcomes. 2020-05-28
Epidemiological and initial clinical characteristics of patients with family aggregation of COVID-19. To investigate the epidemiological history and initial clinical characteristics of 10 patients with family aggregation of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in Western Chongqing, China. 2020-05-27
Chest Imaging in Patients Hospitalized With COVID-19 Infection - A Case Series. COVID-19 infected patients can be asymptomatic carriers or present with mild-to-severe respiratory symptoms. […] In our multicenter case series, we outline the clinical presentations and illustrate the most common imaging manifestations in patients hospitalized with COVID-19. 2020-04-22
ESPEN expert statements and practical guidance for nutritional management of individuals with SARS-CoV-2 infection. In the current document, the European Society for Clinical Nutrition and Metabolism (ESPEN) aims at providing concise guidance for nutritional management of COVID-19 patients by proposing 10 practical recommendations. 2020-05-31
A case of COVID-19 patient with the diarrhea as initial symptom and literature review. The typical clinical manifestations were fever, cough, dyspnea, and myalgia or fatigue. […] Less common symptoms included headache, diarrhea, nausea and vomiting. […] The case demonstrate that gastrointestinal symptoms ware not rare in NCIP, and diarrhea could be the initial symptom. 2020-04-22
Severe Acute Proximal Pulmonary Embolism and COVID-19: A Word of Caution. Here we describe the case of a young woman presenting with severe pulmonary embolism, without any associated symptoms of infections. […] Despite emergency surgical embolectomy, her clinical conditions continued to deteriorate. 2020-04-21
American Society for Transplantation and Cellular Therapy Pharmacy Special Interest Group Position Statement on Pharmacy Practice Management and Clinical Management for COVID-19 in Hematopoietic Cell Transplantation and Cellular Therapy Patients in the United States. The American Society for Transplantation and Cellular Therapy Pharmacy Special Interest Group Steering Committee aims to provide pharmacy practice management recommendations for how to transition clinical HCT or cellular therapy pharmacy services using telemedicine capabilities in the inpatient and outpatient settings to maintain an equivalent level of clinical practice while minimizing viral spread in a high-risk, immunocompromised population. […] In addition, the Steering Committee offers clinical management recommendations for COVID-19 in HCT and cellular therapy recipients based on the rapidly developing literature. […] As the therapeutic and supportive care interventions for COVID-19 expand, collaboration with clinical pharmacy providers is critical to ensure safe administration in HCT recipients. […] The COVID-19 pandemic has challenged all members of the healthcare team, and we must continue to remain vigilant in providing pharmacy clinical services to one of the most high-risk patient populations while also remaining committed to providing compassionate and safe care for patients undergoing HCT and cellular therapies. 2020-05-29
Renin-angiotensin system at the heart of COVID-19 pandemic. We hypothesize that factors related to ethnicity, environment, behaviors, associated illness, and medications involving this complex system are probably responsible for situations regarded as anomalous from both an epidemiological and a clinical point of view, but, taken together, such factors may explain most of the aspects of current outbreak. 2020-05-17
Can post-exposure prophylaxis for COVID-19 be considered as an outbreak response strategy in long-term care hospitals? Based on our experience, further clinical studies are recommended for COVID-19 PEP. 2020-04-29
Combating Devastating COVID -19 by Drug Repurposing. Some counties are against the use of these drugs because of adverse effects associated with drug repurposing and lack of statistically significant clinical data but they were found to be effective in some countries to treat affected COVID-19 patients (Off label/ Investigational). […] There is a need to reassess the in vitro data and to carry out randomised clinical trials. 2020-04-24
Coagulation disorders in coronavirus infected patients: COVID-19, SARS-CoV-1, MERS-CoV and lessons from the past. Preliminary reports on COVID-19 patients’ clinical and laboratory findings include thrombocytopenia, elevated D-dimer, prolonged prothrombin time, and disseminated intravascular coagulation. 2020-05-27
Epidemiology and clinical features of COVID-19: A review of current literature. Studies are rapidly published to share information regarding epidemiology, clinical and diagnostic patterns, and prognosis. 2020-05-28
Review of Artificial Intelligence Techniques in Imaging Data Acquisition, Segmentation and Diagnosis for COVID-19. Moreover, the computer-aided platforms help radiologists make clinical decisions, i.e., for disease diagnosis, tracking, and prognosis. 2020-05-01
Profile of RT-PCR for SARS-CoV-2: a preliminary study from 56 COVID-19 patients. We found virus shedding was up to 6 weeks after onset of symptoms. 2020-04-30
COVID-19 in otolaryngologist practice: a review of current knowledge. Otorhinolaryngological manifestations are common symptoms of COVID-19. […] This study provides a brief and precise review of the current knowledge regarding COVID-19, including disease transmission, clinical characteristics, diagnosis, and potential treatment. […] Upper respiratory tract (URT) symptoms were commonly observed in younger patients and usually appeared initially. […] Ear, nose and throat (ENT) symptoms may precede the development of severe COVID-19. […] Additional studies analyzing why some patients develop ENT symptoms during COVID-19 and others do not are needed. 2020-04-30
The prevention and management of the coronavirus disease 2019 (COVID-19) outbreak in radiology departments in epidemic areas. With the cooperation of the whole hospital and radiology department, a number of effective evaluation methods have been carried out to ensure the optimization of clinical protection. […] To our knowledge, the establishment of standardized protection and clear process has opened up a new idea of epidemic prevention management, which can effectively provide timely, efficient, and accurate support for clinical research, and promote the transformation from clinical research type to scientific research management type. 2020-05-29
Chloroquine for SARS-CoV-2: Implications of Its Unique Pharmacokinetic and Safety Properties. Since in vitro studies and a preliminary clinical report suggested the efficacy of chloroquine for COVID-19-associated pneumonia, there is increasing interest in this old antimalarial drug. […] Clinical experience has shown that chloroquine has a narrow safety margin, as three times the adult therapeutic dosage for malaria can be lethal when given as a single dose. 2020-05-08
Angiotensin-converting enzyme 2 in severe acute respiratory syndrome coronavirus and SARS-CoV-2: A double-edged sword? We reasonably speculate several potential directions of clinical management including host-directed therapies aiming to restore dysregulated RAS caused by ACE2 deficiency. 2020-05-06
Cardiac involvement in COVID-19 patients: Risk factors, predictors, and complications: A review. Although some insights have been garnered in the study of cardiovascular diseases for these patients, these insights remain fragmented and have yet to cement clear guidelines for actionable clinical practice. […] While some information is available, further studies are imperative for a more cohesive understanding of the cardiac pathophysiology in COVID-19 patients to promote more informed treatment and, ultimately, better clinical outcomes. 2020-04-19
D-dimer levels on admission to predict in-hospital mortality in patients with Covid-19. Early and effective predictors of clinical outcomes is urgent needed to improve management of Covid-19 patients. 2020-04-19
Supporting pandemic response using genomics and bioinformatics: A case study on the emergent SARS-CoV-2 outbreak. Pre-clinical responses to fast-moving infectious disease outbreaks heavily depend on choosing the best isolates for animal models that inform diagnostics, vaccines and treatments. 2020-05-25
Successful guselkumab treatment in a psoriatic patient affected with Cornelia de Lange syndrome, and prosecution during the COVID-19 pandemic. The patient had been already treated with topical and traditional therapies, without any clinical benefits. 2020-04-29
[Management strategy for the resumption of regular diagnosis and treatment in gastrointestinal surgery department during the outbreak of coronavirus disease 2019 (COVID-19)]. Based on our clinical practice, the four major measures of strengthening pre-hospital screening, perioperative prevention and control, medical staff protection, and ward management were adopted. […] Our preliminary practice shows that following the work guidelines issued by the Guangdong Province COVID-19 Prevention and Control Office and adopting precise management strategies in combination with the specific clinical features of gastrointestinal surgery, it is possible to safely resume regular care for the patients and comply to epidemic control at the same time. 2020-04-20
[Analysis of selective endoscopy results during the epidemic of coronavirus disease 2019 (COVID-19)]. Methods: A retrospective cohort study was carried out to analyze the clinical data of selective endoscopy performed at the Endoscopic Center, Zhongshan Hospital of Fudan University from February 20 to March 6, 2020. […] Clinical data included epidemiological questionnaire, chief complaints, endoscopic findings and biopsy pathology results, etc. […] Meanwhile, the clinical data of selective endoscopy during the same period from February 20 to March 6, 2019 were collected as the control group to compare the overall results of endoscopy examinations during the epidemic and the detection rate of GI malignancy. […] Conclusion: Compared with the same period in 2019, the number of selective endoscopy decreases sharply during the epidemic period, while the detection rate of various GI malignant tumors increases significantly, which indicates that patients with high-risk symptoms of GI malignancies should still receive endoscopy as soon as possible. […] Provided strict adherence to the epidemic prevention standards formulated by the state and professional societies, it is necessary to carry out clinical diagnosis and treatment as soon as possible. 2020-04-20
[Strengthening basic and clinical research on ocular infection caused by coronavirus]. Based on the previous studies and our own research, we summarize the potential transmission route and clinical symptoms of COVID-2019 in the eye, as well as the further prevention and research, with the expectation of contributing to the development in the field of infectious eye disease in China. 2020-04-20
[Clinical consideration and management of coronavirus disease 2019]. In view of the above questions, this article now puts forwards the corresponding suggestions and considerations from the perspective of clinical infectious diseases physician. 2020-04-21
[Clinical features and outcome of treatment for novel coronavirus pneumonia: a meta-analysis]. Objective: To investigate the clinical features and outcome of treatment for novel coronavirus pneumonia. Methods: Literature on novel coronavirus pneumonia was retrieved from PubMed and EMBASE databases. […] The meta-analysis result showed that the most common clinical symptoms of the novel coronavirus pneumonia were fever (91.6%) and cough (64.5%), followed by dyspnea (32.8%) and sputum (28.1%). […] Headache (10.5%), sore throat (11.2%), hemoptysis (3.2%), diarrhea (6.6%) and the other symptoms were relatively rare. […] Heterogeneity between studies was significant; however, subgroup and sensitivity analysis had failed to identify clear sources of heterogeneity. Conclusion: Fever, cough and liver dysfunction are the main clinical manifestations of this disease and the mortality rate is low. 目的: 自2019年12月首次报道新型冠状病毒肺炎以来,该传染病已迅速发生于全国各地及海外多个国家。 2020-04-20
Clinical and Dynamic Computed Tomography Features of 24 Patients With Coronavirus Disease 2019. To explore the clinical and dynamic computed tomography features of coronavirus disease 2019. […] Symptoms were fever, cough, chest tightness, dyspnea, fatigue, and muscle pain. […] Coronavirus disease 2019 has certain clinical characteristics and typical computed tomography features. 2020-04-20
Peptide-like and small-molecule inhibitors against Covid-19. Potential compounds were screened from the CHEMBL database, ZINC database, FDA approved drugs and molecules under clinical trials. 2020-05-14
Novel 2019 coronavirus structure, mechanism of action, antiviral drug promises and rule out against its treatment. Thousands of compounds including approved drugs and drugs in the clinical trial are available in the literature. 2020-05-06
Development of a reverse transcription-loop-mediated isothermal amplification as a rapid early-detection method for novel SARS-CoV-2. Our RT-LAMP assay is simple to perform, less expensive, time-efficient, and can be used in clinical laboratories for preliminary detection of SARS-CoV-2 in suspected patients. 2020-05-19
Different longitudinal patterns of nucleic acid and serology testing results based on disease severity of COVID-19 patients. Here, we conducted a serial investigation on 21 individuals infected with SARS-CoV-2 in two medical centres from Jiangsu Province, including 11 non-severe COVID-19 patients, and 5 severe COVID-19 patients and 5 asymptomatic carriers based on nucleic acid test and clinical symptoms. […] Such information is of immediate relevance and would assist COVID-19 clinical diagnosis, prognosis and vaccine design. 2020-05-05
Chinese expert consensus on diagnosis and treatment of coagulation dysfunction in COVID-19. The consensus produced 18 recommendations which are being used to guide clinical work. 2020-04-23
Anaesthesia and COVID-19: infection control. The pathogen is spread by human-to-human transmission via droplets exposure and contact transfer, causing mild symptoms in the majority of cases, but critical illness, bilateral viral pneumonia, and acute respiratory distress syndrome (ARDS) in a minority. 2020-05-02
Clinical Consensus Recommendations Regarding Non-Invasive Respiratory Support in the Adult Patient with Acute Respiratory Failure Secondary to SARS-CoV-2 infection. This consensus document has been prepared on evidence-informed guidelines developed by a multidisciplinary panel of health care providers from four Spanish scientific societies (Spanish Society of Intensive Care Medicine [SEMICYUC], Spanish Society of Pulmonologists [SEPAR], Spanish Society of Emergency [SEMES], Spanish Society of Anesthesiology, Reanimation, and Pain [SEDAR]) with experience in the clinical management of patients with COVID-19 and other viral infections, including SARS, as well as sepsis and ARDS. […] The document provides clinical recommendations for the noninvasive respiratory support (noninvasive ventilation, high flow oxygen therapy with nasal cannula) in any patient with suspected or confirmed presentation of COVID-19 with acute respiratory failure. 2020-05-21
Audiological profile of asymptomatic Covid-19 PCR-positive cases. Twenty cases who were confirmed positive for COVID-19 and had none of the known symptoms for this viral infection formed the test group. […] Patients who had definite symptoms of COVID-19 infection as well as those who had a history of hearing loss or a history of any known cause of hearing loss were excluded from the examined sample. 2020-04-23
Embracing telemedicine into your otolaryngology practice amid the COVID-19 crisis: An invited commentary. Medicare has recently allowed “broad flexibilities to furnish services using remote communications technology to avoid exposure risks to health care providers, patients, and the community.” [1] The implementation of telemedicine, or virtual, services, will help the Otolaryngologists provide needed care to patients while mitigating the clinical and financial impact of the pandemic. 2020-04-22
Treatment options for COVID-19: The reality and challenges. Despite the worsening trends of COVID-19, no drugs are validated to have significant efficacy in clinical treatment of COVID-19 patients in large-scale studies. […] A large-scale study investigating the clinical efficacy of remdesivir (200 mg on day 1, followed by 100 mg once daily) is on-going. […] Another promising alternative is hydroxychloroquine (200 mg thrice daily) plus azithromycin (500 mg on day 1, followed by 250 mg once daily on day 2-5), which showed excellent clinical efficacy on Chinese COVID-19 patients and anti-SARS-CoV-2 potency in vitro. 2020-05-02
French consensus regarding precautions during tracheostomy and post-tracheostomy care in the context of COVID-19 pandemic. Nevertheless, patients without clinical or radiological (CT scan) markers of COVID-19, and with negative nasopharyngeal sample within 24h of surgery, are at low risk of being infected. 2020-05-22
Severe cerebral involvement in adult-onset hemophagocytic lymphohistiocytosis. HLH with cerebral involvement should be considered in patients presenting with severe systemic inflammatory response syndrome (SIRS) but negative cultures and unusual or unexpectedly severe clinical and/or radiologic signs of cerebral dysfunction. 2020-04-23
[Practical update of total dose compensation in case of temporary interruption of external radiotherapy in the COVID-19 pandemic context]. The models used to compensate the total dose in case of temporary treatment interruption are well known but it is of importance in that pandemic context to update and homogenize clinical practice in order to improve local control without increasing normal tissue complications. 2020-04-26
Clinical characteristics and diagnostic challenges of pediatric COVID-19: A systematic review and meta-analysis. The clinical characteristics and spectrum are still unknown. […] A random effects model was used to pool clinical data in the meta-analysis. […] Gastrointestinal symptoms (12%) were uncommon. 2020-05-13
Documented early circulation of Coronavirus Disease 2019 (COVID-19) in Florida, USA, since February 2020. The patient developed symptoms on 3rd March while staying in Miami where he arrived on 12th February. 2020-04-30
Down-regulated gene expression spectrum and immune responses changed during the disease progression in COVID-19 patients. Here, we investigated the clinical, cytokine levels, T cell proportion and related gene expression occurring in COVID-19 patients on admission and after intial treatment. 11 patients diagnosed as COVID-19 with similar initial treatment regimen were enrolled in the hospital. […] Cough and fever were the top symptoms in the 11 COVID-2019 cases. 2020-04-30
Therapeutic strategies for critically ill patients with COVID-19. Since the 2019 novel coronavirus disease (COVID-19) outbreak originated from Wuhan, Hubei Province, China, at the end of 2019, it has become a clinical threat to the general population worldwide. 2020-04-23
CD147 as a Target for COVID-19 Treatment: Suggested Effects of Azithromycin and Stem Cell Engagement. Clinical tests with allogeneic MSCs from healthy individuals are underway to enhance endogenous lung repair and suppress inflammation. 2020-05-29
CoViD-19 Immunopathology and Immunotherapy. Recent clinical trials to rescue Tex show promising outcomes. 2020-04-23
Epidemiologic and Clinical Characteristics of 26 Cases of COVID-19 Arising from Patient-to-Patient Transmission in Liaocheng, China. Most studies to date on COVID-19 have focused on disease etiology and the genomics of 2019-nCoV, with few reports on the epidemiologic and clinical characteristics of infected patients. […] We report early clinical features of 26 patients with confirmed COVID-19 who were admitted to Liaocheng Infectious Disease Hospital in Shandong Province. 2020-04-23
First COVID-19 infections in the Philippines: a case report. We describe the clinical and epidemiological aspects of the first two confirmed COVID-19 cases in the Philippines, both admitted to the national infectious disease referral hospital in Manila. […] Patient 1, a 39-year-old female, had symptoms of cough and sore throat and was admitted to San Lazaro Hospital in Manila on January 25. […] Her symptoms resolved, and she was discharged. […] Patient 2, a 44-year-old male, had symptoms of fever, cough, and chills. Influenza B and Streptococcus pneumoniae were detected by PCR on initial NPS/OPS swabs. […] This case report highlights several important clinical and public health issues. […] Despite both patients being young adults with no significant past medical history, they had very different clinical courses, illustrating how COVID-19 can present with a wide spectrum of disease. 2020-04-23
Treatment efficacy analysis of traditional Chinese medicine for novel coronavirus pneumonia (COVID-19): an empirical study from Wuhan, Hubei Province, China. Thus, we aimed to explore TCM characteristics of clinical efficacy to NCP, as well as to optimize Qingfei Paidu decoction (QFPDD) and the recommended formulas to NCP by National Health Commission (NHC). […] Chinese medical sciences theory and clinical application of TCM were analyzed. […] A total of 54 NCP patients were observed in a hospital from Wuhan, whose clinical characteristics and utilization of Chinese Medicines (CMs) were described. […] TCM has a systemic theoretical understanding on the pathological evolution and a positive clinical efficacy on NCP. 2020-04-23
Abdominal Pain: A Real Challenge in Novel COVID-19 Infection. The most common manifestation is flu-like symptoms. […] Gastrointestinal symptoms are less common but possible and more difficult to recognize as part of a COVID-19 syndrome. […] We report the cases of COVID-19 patients admitted to our Emergency Department who complained of gastrointestinal symptoms at admission. […] The novel COVID-19 infection is a severe public health problem which is causing an increasing number of deaths worldwide.Although uncommon, there may be a relationship between gastrointestinal symptoms and COVID-19, as reported in recent studies.Early detection and isolation of patients with COVID-19 infection is the only way to control and limit the global spread of this virus. 2020-04-22
Anosmia and Dysgeusia in the Absence of Other Respiratory Diseases: Should COVID-19 Infection Be Considered? We describe two elderly patients evaluated at emergency departments for anosmia/dysgeusia in the absence of any other respiratory symptoms prior to or upon admission. […] In the current epidemiological context, clinical and biological work-up led to a diagnosis of COVID-19 infection. […] In the current epidemiological situation, anosmia and dysgeusia in the absence of other respiratory conditions should be carefully evaluated.Special attention should be given to patients with non-classic COVID-19 symptoms in order to reduce transmission and protect health providers. 2020-05-27
A quickly, effectively screening process of novel corona virus disease 2019 (COVID-19) in children in Shanghai, China.
  1. We followed up 68 patients in isolation at home until symptoms disappeared.
COVID-19 Clinical Trials: A Primer for the Cardiovascular and Cardio-Oncology Communities. The COVID-19 pandemic has resulted in a proliferation of clinical trials that are designed to slow the spread of SARS-CoV-2, the virus that causes COVID-19. […] Here we have provided a foundation for cardiovascular and cardio-oncology physicians who are on the frontline providing care to COVID-19 patients, so that they can better understand the emerging cardiovascular epidemiology of COVID-19, as well as the biological rationale for the clinical trials that are ongoing for the treatment of COVID-19 patients. 2020-05-31
Antiviral therapy in management of COVID-19: a systematic review on current evidence. In addition, clinical trials on the efficacy of antiviral therapies in the management of Severe Acute Respiratory Syndrome coronavirus (SARS-Cov) or Middle East Respiratory Syndrome coronavirus (MERS-CoV) have also been reviewed, in order to identify potential treatment options for COVID-19. […] Only one clinical trial on the efficacy of antiviral therapy in management of COVID-19 was found. […] In addition, no clinical trials were found to be performed on the efficacy of antiviral agents in the management of SARS-CoV and MERS-CoV. […] In the time of the current pandemic and future epidemics, organizations such as WHO should pursue more proactive actions and plan well-designed clinical trials so that their results can be used in managing future epidemics. 2020-04-23
COVID-19 Pneumonia in Asymptomatic Trauma Patients; Report of 8 Cases. In this study, we reported 8 incidentally detected cases of COVID-19 pneumonia in chest computed tomography (CT) scan of patients referred to emergency department following multiple trauma without any respiratory symptoms. 2020-04-23
Prone Position in Management of COVID-19 Patients; a Commentary. SARS-CoV-2 virus causes a pneumonia that was identified through fever, dyspnea, and acute respiratory symptoms and named COVID-19. 2020-04-23
Coronavirus Infections in Children Including COVID-19: An Overview of the Epidemiology, Clinical Features, Diagnosis, Treatment and Prevention Options in Children. In humans, CoVs mostly cause respiratory and gastrointestinal symptoms. […] Clinical manifestations range from a common cold to more severe disease such as bronchitis, pneumonia, severe acute respiratory distress syndrome, multi-organ failure and even death. […] SARS-CoV, MERS-CoV and SARS-CoV-2 seem to less commonly affect children and to cause fewer symptoms and less severe disease in this age group compared with adults, and are associated with much lower case-fatality rates. […] Preliminary evidence suggests children are just as likely as adults to become infected with SARS-CoV-2 but are less likely to be symptomatic or develop severe symptoms. […] Children more often have gastrointestinal symptoms compared with adults. […] The majority of children infected by novel CoVs have a documented household contact, often showing symptoms before them. […] In this review, we summarize epidemiologic, clinical and diagnostic findings, as well as treatment and prevention options for common circulating and novel CoVs infections in humans with a focus on infections in children. 2020-04-24
Detection of SARS-CoV-2 RNA and Antibodies in Diverse Samples: Protocol to Validate the Sufficiency of Provider-Observed, Home-Collected Blood, Saliva, and Oropharyngeal Samples. Therefore, more flexible options for screening for SARS-CoV-2 RNA and serologic responses are critical to inform clinical and public health responses. […] Providers will record whether they are confident in the suitability of the specimen for laboratory testing that would inform clinical decision making. 2020-04-30
[ACE-inhibitors, angiotensin receptor blockers and severe acute respiratory syndrome caused by coronavirus]. However, there is no clinical evidence to support this hypothesis. […] In the light of the above considerations, it is reasonable to conclude that the suggestion to discontinue ACE-inhibitors or ARBs in all patients with the aim of preventing or limiting the diffusion of SARS-CoV-2 virus is not based on clinical evidence. […] Controlled clinical studies in this area are eagerly awaited. 2020-04-22
[New insights into the seriousness of acute myocardial injury during COVID-19]. Some pathophysiological reasons have been hypothesized regarding the frequently observed increase in troponin levels in patients hospitalized with COVID-19, but, at the moment, these data could already suggest some clinical management implications, also with the aim of prospectively collecting research data: a troponin dosage should be considered, as a prognostic indicator, in all patients with moderate/severe COVID-19 at hospital admission, periodically during hospitalization, and in the case of clinical deterioration. […] In those patients with increased troponin levels, serial determinations should be carried out to define the enzymatic trajectory and therefore also the degree of clinical attention that must necessarily be closer in those who turn out to have persistently high or increasing troponin levels. 2020-04-22
[The role of multimodality imaging in COVID-19 patients: from diagnosis to clinical monitoring and prognosis]. The integrated clinical, laboratory and ultrasound approach is essential for the diagnosis, monitoring and evaluation of the patient’s therapy in COVID-19 pneumonia. 2020-04-22
[Being a cardiologist at the time of SARS-COVID-19: is it time to reconsider our way of working?] Our opinion is that a syndemic approach, which considers the complex interplay between social, economic, environmental and clinical problems, can be the most appropriate and achieved by means the contribution of telemedicine and telecardiology, intended as integration and not as an alternative to traditional management. […] A flexible use of telematic tools, now available for teleconsultation, and/or remote monitoring adapted to the needs of clinical, family and social-health contexts could allow the creation of integrated and personalized management programs that are effective and efficient for the care of patients. 2020-04-22
Positive result of Sars-Cov-2 in faeces and sputum from discharged patient with COVID-19 in Yiwu, China. To analyse the clinical prognosis of discharged COVID-19 patients by monitoring their SAR-CoV-2 nucleic acid status, which may provide evidence to establish discharge standards and follow-up management for COVID-19 patients. […] The patient’s daily clinical signs were recorded and sputum and faecal specimens were regularly sent for the detection of SARS-CoV-2 nucleic acid. […] The time between initial symptoms and meeting discharge criteria was 18 - 44 days with an average of 25 ± 6 days. 2020-04-20
Description of COVID-19 cases along with the measures taken on prevention and control in Zhejiang, China. Under the outbreak of COVID-19, it was urgent to analyze the cases from clinical features and epidemiological factors, as well as understand the effectiveness of measures taken on disease prevent and control. […] A retrospective study was applied for descriptive analysis of clinical features and epidemiological factors of confirmed cases in four cities of Zhejiang. […] Clinical features of fever and cough were found mostly happen on patients. 2020-05-22
SARS-CoV-2 and viral sepsis: observations and hypotheses. Since the outbreak of coronavirus disease 2019 (COVID-19), clinicians have tried every effort to understand the disease, and a brief portrait of its clinical features have been identified. […] In clinical practice, we noticed that many severe or critically ill COVID-19 patients developed typical clinical manifestations of shock, including cold extremities and weak peripheral pulses, even in the absence of overt hypotension. […] Understanding the mechanism of viral sepsis in COVID-19 is warranted for exploring better clinical care for these patients. 2020-05-12
Coronavirus disease 2019 during pregnancy: a systematic review of reported cases. This study aimed to conduct a systematic review of the clinical outcomes reported for pregnant patients with coronavirus disease 2019. […] Coronavirus disease 2019 associated with respiratory insufficiency in late pregnancies certainly creates a complex clinical scenario. 2020-05-16
Detection and analysis of nucleic acid in various biological samples of COVID-19 patients. However, there are few reports on clinical application of 2019-nCoV nucleic acid detection in other biological samples. […] COVID-19 diagnostic criteria: according to China’s ⟪pneumonia diagnosis and treatment Program of novel coronavirus infection (trial version 7) ⟫, in accordance with the relevant epidemiological and clinical manifestations, nasopharyngeal swabs real-time fluorescence RT-PCR detection of 2019-nCoV nucleic acid positive, COVID-19 cases were divided into mild, ordinary, severe and severe [1]. […] Simple detection of nasopharyngeal swab 2019-nCoV nucleic acid detection positive rate is not high, multi-sample 2019-nCoV nucleic acid detection can improve the accuracy, reduce the false negative rate, better guide clinical treatment and evaluate the therapeutic effect. 2020-05-13
Specific ACE2 expression in small intestinal enterocytes may cause gastrointestinal symptoms and injury after 2019-nCoV infection. The infected patients presented with fever, respiratory symptoms, sometimes with digestive and other systemic manifestations, and some progressed with a severe acute respiratory syndrome or even death. […] Associated digestive symptoms were frequently observed in the patients, with an unknown significance and mechanism. […] We collected the clinical data of the 2019-nCoV-infected patients from published studies and extracted the data about the incidence of gastrointestinal symptoms. […] Furthermore, we used online datasets to analyze ACE2 expression in different human organs, especially in the small intestine, to explore the relationship between ACE2 expression patterns and clinical symptoms. […] High expression of ACE2 on the surface cells in the digestive tract may lead to gastrointestinal symptoms and inflammation susceptibility. […] Overall, digestive symptoms were common in the COVID-19 patients. […] It is a possible mechanism of digestive symptoms in the COVID-19 patients and explains the presence of the virus in patients’ stool samples. 2020-05-31
Diarrhea Is Associated With Prolonged Symptoms and Viral Carriage in Corona Virus Disease 2019. We compared clinical, laboratory, radiological, and outcome features of patients with SARS-CoV-2 infection (COVID-19) with pneumonia, with vs without diarrhea. 2020-05-28
Reorganisation of medical oncology departments during the novel coronavirus disease-19 pandemic: a nationwide Italian survey. In the midst of the epidemic in Italy, the CIPOMO promoted a national survey aiming to evaluate the impact of COVID-19 on clinical activity of oncologists and the implementation of containment measures of COVID-19 diffusion. 2020-05-29
Clinical features and short-term outcomes of 221 patients with COVID-19 in Wuhan, China. We aimed to study the epidemiology, clinical features and short-term outcomes of patients with COVID-19 in Wuhan, China. […] Most common symptoms in severe patients were high fever, anorexia and dyspnea. […] As of February 15, 2020, 19.0% patients had been discharged and 5.4% patients died. 80% of severe cases received ICU (intensive care unit) care, and 52.3% of them transferred to the general wards due to relieved symptoms, and the mortality rate of severe patients in ICU was 20.5%. […] Patients with elder age, chronic comorbidities, blood leukocyte/lymphocyte count, procalcitonin level, co-infection and severe complications might increase the risk of poor clinical outcomes. 2020-05-27
SARS-Cov-2 infection: Response of human immune system and possible implications for the rapid test and treatment. Considering the clinical impact of the new outbreak, it is highly important to study the potential responses of the human immune system during the SARS-CoV-2 infection as well as the role of virus-specific T cells and by B-lymphocytes. 2020-05-28
Airborne transmission of severe acute respiratory syndrome coronavirus-2 to healthcare workers: a narrative review. We propose that transmission is associated with time in proximity to severe acute respiratory syndrome coronavirus-1 patients with respiratory symptoms, rather than the procedures per se. 2020-05-08
Comparing Rapid Scoring Systems in Mortality Prediction of Critically Ill Patients With Novel Coronavirus Disease. A total of 138 medical records of critically ill patients with COVID-19 were included in the study. […] Demographic and clinical characteristics on admission used for calculating Modified Early Warning Score (MEWS) and Rapid Emergency Medicine Score (REMS) and outcomes (survival or death) were collected for each case and extracted for analysis. 2020-05-21
Management of acute myocardial infarction during the COVID-19 pandemic: A Consensus Statement from the Society for Cardiovascular Angiography and Interventions (SCAI), the American College of Cardiology (ACC), and the American College of Emergency Physicians (ACEP). This document addresses the care of these patients focusing on (a) varied clinical presentations; (b) appropriate personal protection equipment (PPE) for health care workers; (c) the roles of the emergency department, emergency medical system, and the cardiac catheterization laboratory (CCL); and (4) regional STEMI systems of care. 2020-05-14
COVID-19 and the clinical hematology laboratory. Like SARS and MERS, COVID-19 infection manifests most frequently with lower respiratory symptoms. […] In addition to its central role in the diagnosis of COVID-19 infection, the clinical laboratory provides critical information to clinicians regarding prognosis, disease course, and response to therapy. 2020-04-20
Experiences of Patients With Rheumatic Diseases in the United States During Early Days of the COVID-19 Pandemic. Participants in a US-wide longitudinal observational registry responded to a supplemental COVID-19 questionnaire by e-mail on March 25, 2020, about their symptoms, COVID-19 testing, health care changes, and related experiences during the prior 2 weeks. […] Analysis compared responses by diagnosis, disease activity, and new onset of symptoms. 2020-05-09
Thromboembolic events and apparent heparin resistance in patients infected with SARS-CoV-2. One of the most important clinical features of the infection is a profound coagulopathy. 2020-04-20
Imaging features and mechanisms of novel coronavirus pneumonia (COVID-19): Study Protocol Clinical Trial (SPIRIT Compliant). The distribution and morphology of lesions on chest CT, clinical data will be recorded. 2020-04-23
Variable computed tomography appearances of COVID-19. While sensitive for detecting lung parenchymal abnormalities in COVID-19 pneumonia, CT for initial diagnosis is discouraged and should be reserved for specific clinical indications. […] Interpretation of chest CT findings should be correlated with duration of symptoms to better determine the disease stage and aid in patient management. 2020-04-21
Coronavirus disease 2019 (COVID-19): two case reports from a family cluster. As two important means of examination, computed tomography (CT) and real-time reverse transcription polymerase chain reaction (RT-PCR) have always been controversial in the clinical diagnosis of COVID-19 pneumonia. […] Here, we report a family cluster case of a father and a son diagnosed as COVID-19 at our hospital, and described the clinical manifestations, laboratory results, CT changes, diagnosis and treatment strategy of these two patients. […] For patient 2 (son), the clinical symptoms were not obvious, but CT imaging clearly displayed dynamic changes of the lung lesions. […] Therefore, in clinical work, doctors should make full use of the advantages of CT and RT-PCR, and take other measures to make up for their disadvantages. 2020-04-21
Insights on Otolaryngology Residency Training during the COVID-19 Pandemic. The decrease in clinical opportunities due to the limitations on elective surgical cases and office visits as well as potential resident redeployment could lead to a decline in overall experience as well as key indicator cases. 2020-04-21
Impact of the COVID-19 Pandemic on the Management of Head and Neck Malignancies. Immediate measures to reduce transmission rates and protect patients and providers take priority and necessitate some delays in care, particularly for patients with mild symptoms or less aggressive cancers. 2020-04-21
[Recommendations on the identification and transfer of children with critical diabetes during the COVID-19 outbreak]. The Subspecialty Group of Endocrinology and Metabolism, Society of Pediatrics, Chinese Medical Association and the Subspecialty Group of Endocrinology and Metabolism, Society of Pediatrics, Chinese Medical Doctor Association have developed the recommendations on the identification and transfer of children with critical diabetes during the COVID-19 outbreak, which provide a reference for primary doctors to quickly assess the severity of patient’s condition and treat the illness accordingly, thus reducing the risk of referral infection and improving clinical prognosis. 2020-04-22
[Clinical features of children with SARS-CoV-2 infection: an analysis of 115 cases]. To study the clinical features of children with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. […] A retrospective analysis was performed for the clinical data of 115 children who were diagnosed with SARS-CoV-2 infection in the Wuhan Children’s Hospital, including general information, history of close contact with individuals of SARS-CoV-2 infection, early clinical symptoms, laboratory examination results, and lung CT results. […] As for clinical symptoms, 29 children (25.2%) had fever, 47 (40.9%) had respiratory symptoms (including cough, rhinorrhea, and nasal congestion), and 61 (53.0%) were asymptomatic. 2020-04-22
[Clinical features of children with SARS-CoV-2 infection: an analysis of 13 cases from Changsha, China]. To study the clinical features of children with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. […] A retrospective analysis was performed for the clinical data of 13 children with SARS-CoV-2 infection who hospitalized in a Changsha hospital. […] Of the 13 children, 2 had no symptoms, and the other 11 children had the clinical manifestations of fever, cough, pharyngeal discomfort, abdominal pain, diarrhea, convulsions, or vomiting. […] As for clinical typing, 7 had mild type, 5 had common type, and 1 had severe type. […] Mild and common types are the major clinical types in children with SARS-CoV-2 infection, and cytokine storm is not observed. 2020-04-22
[Research advances in cardiovascular system damage caused by SARS-CoV-2 in children]. In addition to the typical respiratory symptoms, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection also has the clinical symptoms of cardiovascular system damage. 2020-04-22
Advice Regarding Systemic Therapy in Patients with Urological Cancers During the COVID-19 Pandemic. We provide treatment advice as a pragmatic perspective on the risk/benefit ratio in specific clinical scenarios. 2020-05-28
[Ensuring mental health care during the SARS-CoV-2 epidemic in France: A narrative review]. They should also be trained to prevent, detect and treat early warning symptoms of post-traumatic stress disorder, because their prevalence was high in the regions of China most affected by the pandemic. 2020-05-08
Emergency tracheal intubation in 202 patients with COVID-19 in Wuhan, China: lessons learnt and international expert recommendations. Clinical information on airway management and expert recommendations in these patients are urgently needed. […] Based on clinical information and expert recommendation, we propose detailed planning, strategy, and methods for tracheal intubation in COVID-19 patients. 2020-05-02
COVID-19 pneumonia with hemoptysis: Acute segmental pulmonary emboli associated with novel coronavirus infection. The overlap in the signs and symptoms of COVID-19 associated Acute Respiratory Distress Syndrome (ARDS) and COVID-19 with concurrent pulmonary embolism creates a diagnostic challenge for emergency medicine physicians in patients already at risk for renal impairment. […] Additionally, the presence of right heart strain on electrocardiography (EKG) is a well described clinical presentations of pulmonary embolism not reported commonly with COVID-19 infections. 2020-04-26
Clinical consensus recommendations regarding non-invasive respiratory support in the adult patient with acute respiratory failure secondary to SARS-CoV-2 infection. This consensus document has been prepared on evidence-informed guidelines developed by a multidisciplinary panel of health care providers from four Spanish scientific societies (Spanish Society of Intensive Care Medicine [SEMICYUC], Spanish Society of Pulmonologists [SEPAR], Spanish Society of Emergency [SEMES], Spanish Society of Anesthesiology, Reanimation, and Pain [SEDAR]) with experience in the clinical management of patients with COVID-19 and other viral infections, including SARS, as well as sepsis and ARDS. […] The document provides clinical recommendations for the noninvasive respiratory support (noninvasive ventilation, high flow oxygen therapy with nasal cannula) in any patient with suspected or confirmed presentation of COVID-19 with acute respiratory failure. 2020-04-21
Guillain Barre syndrome associated with COVID-19 infection: A case report. Coronaviruses can cause multiple systemic infections that respiratory complications are the most obvious symptoms. […] In this report, we describe the symptoms of Guillain Barre syndrome (GBS) in one infected patient with COVID-19, for the first time. 2020-04-23
COVID-19 and ENT Pediatric otolaryngology during the COVID-19 pandemic. Guidelines of the French Association of Pediatric Otorhinolaryngology (AFOP) and French Society of Otorhinolaryngology (SFORL). A nation-wide workgroup drew guidelines based on clinical experience, national and local recommendations and scientific literature. 2020-05-22
Adapting to a Pandemic - Conducting Oncology Trials during the SARS-CoV-2 Pandemic. Clinical trials and other research activities are inevitably impacted. […] Regulatory bodies have issued guidance on managing clinical trials during the pandemic, including contingency measures for remote study visits, delivery of investigational product, and site monitoring visits. […] New cancer clinical trial practices during the SARS-CoV-2 pandemic include new risk assessment strategies, decentralized and remote trial coordination, data collection, and delegation of specific therapeutic activities. […] This experience could provide evidence of more feasible and cost-effective methods for future clinical trial conduct. 2020-05-21
AI governance in the public sector: Three tales from the frontiers of automated decision-making in democratic settings. In this regard, it discusses the specific effects of automated decision support systems on public services and the growing expectations for governments to play a more prevalent role in the digital society and to ensure that the potential of technology is harnessed, while negative effects are controlled and possibly avoided. 2020-04-21
2019 novel coronavirus: an emerging global threat. The most common presenting symptoms are fever, cough, dyspnea, and myalgias and/or fatigue. 2020-04-23
Chest CT Findings of Early and Progressive Phase COVID-19 Infection from a US Patient. The utility of the noncontrast CT chest in the diagnosis of COVID-19 has been controversial, but there are specific imaging findings that have been increasingly associated with this virus in the appropriate clinical context. 2020-05-31
A Review of Salivary Diagnostics and Its Potential Implication in Detection of Covid-19. Saliva has also been used in screening respiratory viruses among hospitalized patients without pyrexia or respiratory symptoms. […] Salivary diagnostics is a dynamic field that is being incorporated as part of disease diagnosis, clinical monitoring of systemic health and to make significant clinical decisions for patient care. 2020-04-23
Tracing New Clinical Manifestations in Patients with COVID-19 in Chile and Its Potential Relationship with the SARS-CoV-2 Divergence. In this review, we discuss the current implications of the changing genomic epidemiology of the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), etiological agent of the Coronavirus Disease 2019 (COVID-19) and its potential relationship with the change of clinical manifestations in patients with confirmed infection. […] Simultaneously, also new clinical manifestations are observed, particularly more prominent gastrointestinal and neurological findings. […] SARS-CoV-2/COVID-19 is changing not only its epidemiology, but also its genomic diversity and clinical manifestations, both aspects coupled, needs to be considered in the study of this ongoing pandemic. 2020-04-23
Guillain-Barré Syndrome associated with SARS-CoV-2 infection. Clinicians should consider this entity since it may warrant appropriate isolation precautions especially in a patient who may not present primarily with typical constitutional and respiratory symptoms associated with COVID-19. 2020-05-31
COVID-19 Clinical Trials: A Primer for the Cardiovascular and Cardio-Oncology Communities. The COVID-19 pandemic has resulted in a proliferation of clinical trials that are designed to slow the spread of SARS-CoV-2, the virus that causes COVID-19. […] Here we have provided a foundation for cardiovascular and cardio-oncology physicians who are on the frontline providing care to COVID-19 patients, so that they can better understand the emerging cardiovascular epidemiology of COVID-19, as well as the biological rationale for the clinical trials that are ongoing for the treatment of COVID-19 patients. 2020-05-22
Medically unexplained symptoms in the times of Covid-19 pandemic: a case-report. Somatic symptom disorder (SSD) is characterized by a dysfunctional preoccupation with physical symptoms leading to excessive and unnecessary healthcare utilization. […] We report a detailed clinical case of a 16 years old adolescent, who presented with a history suggestive of COVID-19 infection and associated psychological distress. […] When COVID-19-like symptoms occur, we highlight the importance of differentially diagnosing a possible exacerbation of a pre-existing SSD, triggered by fear of being infected. 2020-05-20
Coronavirus Disease 19 (COVID-19) complicated with pneumonia in a patient with rheumatoid arthritis receiving conventional disease-modifying antirheumatic drugs. Her symptoms and laboratory results gradually improved. 2020-05-04
Bariatric Surgical Practice During the Initial Phase of COVID-19 Outbreak. Patients developed their symptoms (fever, cough, dyspnea, and fatigue) 1, 2, 4, and 14 days after surgery. 2020-04-23
Clinical Manifestation and Laboratory Characteristics of SARS-CoV-2 Infection in Pregnant Women. Changes in clinical features, laboratory characteristics, and imaging features of pregnant women during the pre-partum and post-partum periods require further elucidation. […] Here, we retrospectively analyzed the clinical features, laboratory characteristics, and imaging features of eight pregnant cases of SARS-CoV-2 infection during the pre-partum and post-partum periods. 2020-05-08
[ACE2 and coronavirus - a question of balance and dynamics?] A similar effect of SARS-CoV-2 could partly explain risk factors and symptoms, and could potentially be treatable. 2020-04-27
Comment on “Cutaneous manifestations in COVID-19: a first perspective” by Recalcati S. Having been infected by severe acute respiratory syndrome coronavirus 2 (SARS-COV-2), patients with COVID-19 mainly present with fever and respiratory symptoms (2). 2020-04-21
Challenges of COVID-19 pandemic for dermatology. We discuss the available data on cutaneous symptoms, although disease-specific symptoms have yet not been observed. […] The consequences for systemic treatment are obvious but it will be most important to collect the clinical data for a better decision process. 2020-05-22
COVID-19 and psoriasis: Should we fear for patients treated with biologics? Previous coronaviruses outbreaks reports, current published evidences on pathogenesis and on clinical reports of COVID infection in immunosuppressed patients are used to make a scientifically based decision. 2020-05-22
Case Report: The First Case of Novel Coronavirus Disease (COVID-19) in Bhutan. He presented initially with vague gastrointerestinal symptoms and later a cough. […] Subsequently, the patient’s clinical status improved, and after 8 days of hospitalization, he was transferred out of the country, where he recovered. 2020-04-21
What’s New With the Old Coronaviruses? Coronaviruses contribute to the burden of respiratory diseases in children, frequently manifesting in upper respiratory symptoms considered to be part of the “common cold.” Recent epidemics of novel coronaviruses recognized in the 21st century have highlighted issues of zoonotic origins of transmissible respiratory viruses and potential transmission, disease, and mortality related to these viruses. 2020-05-04
Letter to the Editor: Acute hypertriglyceridemia in patients with COVID-19 receiving tocilizumab. Given the paucity of robust clinical trial data for most COVID-19 pharmacotherapies at this time, clinicians should continue to remain steadfast in recognition of interventions that improve clinical outcomes and vigilant in monitoring for acute adverse effects that are difficult to detect in clinical trials with small sample sizes. 2020-05-12
CT imaging features of 4121 patients with COVID-19: A meta-analysis. We systematically reviewed the computed tomography (CT) imaging features of coronavirus disease 2019 (COVID-19) to provide reference for clinical practice. 2020-04-29
Comment on Li et al.: COVID-19 patients’ clinical characteristics, discharge rate, and fatality rate of meta-analysis. I have read with great interest the article “COVID-19 patients’ clinical characteristics, discharge rate, and fatality rate of meta-analysis” by Li and colleagues1 . […] The authors have conducted a comprehensive search for articles concerning the clinical characteristics of Chinese patients with COVID-19. 2020-04-21
Central Nervous System Involvement by Severe Acute Respiratory Syndrome Coronavirus -2 (SARS-CoV-2). Our observations of virus in neural tissue, in conjunction with clinical correlates of worsening neurologic symptoms, pave the way to a closer understanding of the pathogenic mechanisms underlying CNS involvement by SARS-CoV-2. 2020-05-20
Participant and Caregiver Perspectives on Clinical Research During Covid-19 Pandemic. The COVID-19 pandemic has massively disrupted essential clinical research. […] The objective was to study older participants’ and their caregivers’ perspectives to participate in ongoing clinical research during the COVID-19 pandemic. […] VISN-16/Geriatric Research, Education and Clinical Center (GRECC), Department of Veterans Affairs. […] Older participants and their caregivers (N = 51) enrolled in ongoing clinical research studies. 2020-05-05
Varicella-like exanthem associated with COVID-19 in an 8-year-old girl: A diagnostic clue? We hereby present a case of COVID-19-associated varicella-like exanthem in an 8-year-old girl with mild systemic symptoms. 2020-05-19
COVID-19 in a High-Risk Dual Heart and Kidney Transplant Recipient. In this report, we present a dual-organ (heart/kidney) transplant recipient who was found to have COVID-19 and, despite the presence of a number of risk factors for poor outcomes, had a relatively mild clinical course. 2020-04-21
Fast Identification of Possible Drug Treatment of Coronavirus Disease-19 (COVID-19) through Computational Drug Repurposing Study. Taking advantage of a recently released crystal structure of SARS-CoV-2 main protease in complex with a covalently bonded inhibitor, N3 (Liu et al., 10.2210/pdb6LU7/pdb), I conducted virtual docking screening of approved drugs and drug candidates in clinical trials. 2020-05-07
Atypical presentation of COVID-19 in a frail older person. Common symptoms of pandemic coronavirus disease (COVID-19) include fever and cough. […] We describe a 94-year-old man with well-controlled schizoaffective disorder, who presented with non-specific and atypical symptoms: delirium, low-grade pyrexia and abdominal pain. […] This has implications for the screening, assessment and isolation of frail older people to COVID-specific clinical facilities and highlights the potential for spread among healthcare professionals and other patients. 2020-04-30
Clinical and Autoimmune Characteristics of Severe and Critical Cases of COVID-19. In this study we report on the clinical and autoimmune characteristics of severe and critical novel coronavirus pneumonia caused by severe acute respiratory syndrome-associated coronavirus 2 (SARS-CoV-2). […] The clinical, autoimmune, and laboratory characteristics of 21 patients who had laboratory-confirmed severe and critical cases of coronavirus disease 2019 (COVID-19) from the intensive care unit of the Huangshi Central Hospital, Hubei Province, China, were investigated. […] Cough (90.5%) and fever (81.0%) were the dominant symptoms, and most patients (76.2%) had at least one coexisting disorder on admission. […] We also retrospectively analyzed the clinical and laboratory data from 21 severe and critical cases of COVID-19. 2020-05-14
Laboratory data analysis of novel coronavirus (COVID-19) screening in 2510 patients. We tried to find some useful information by analyzing the covid-19 screening data, so as to provide help for clinical practice. 2020-05-30
Current epidemiological and clinical features of COVID-19; a global perspective from China. Based on the published data, this review systematically discusses the etiology, epidemiology, clinical characteristics, and current intervention measures related to COVID-19 in the hope that it may provide a reference for future studies and aid in the prevention and control of the COVID-19 epidemic. 2020-05-16
Suppressed T cell-mediated immunity in patients with COVID-19: A clinical retrospective study in Wuhan, China. We found a significant decrease of T lymphocyte subsets and an increase of inflammatory cytokines of hospitalized patients with COVID-19 in clinical practice. […] Demographic, clinical, laboratory information, especially T lymphocyte subsets and inflammatory cytokines were reported. 2020-04-26
Challenges of managing the asymptomatic carriers of SARS-CoV-2. Presently, the World Health Organization indicates that the fatality rate due to COVID-19 is about 2%, inferring that many positive subjects may potentially overcome the illness with mild influenza-like symptoms and no need for hospitalization at intensive-care units. 2020-05-03
Prevalence and severity of corona virus disease 2019 (COVID-19): A systematic review and meta-analysis. Medline, SinoMed, EMBASE, and Cochrane Library were searched for clinical and epidemiological studies on confirmed cases of COVID-19. […] The incidence of fever, cough, fatigue, and dyspnea symptoms were 85.6 % (95CI 81.3-89.9 %), 65.7 % (95CI 60.1-71.4 %), 42.4 % (95CI 32.2-52.6 %) and 21.4 % (95CI 15.3-27.5 %). 2020-05-27
COVID-19 in a MS patient treated with ocrelizumab: does immunosuppression have a protective role? However, it has been speculated that overactive immune response could drive clinical deterioration and, based on this hypothesis, several immunosuppressants are currently being tested as potential treatment for COVID-19. […] Despite complete B cell depletion, patient symptoms abated few days after hospitalization, and he was discharged to home-quarantine. […] Phone interview follow-up confirmed that, after 14 days, no new symptoms occurred. 2020-05-26
COVID-19, Chloroquine Repurposing, and Cardiac Safety Concern: Chirality Might Help. Besides the ethical concern related to accelerated large-scale clinical trials of drugs with unproven efficacy, the known potential detrimental cardiac effects of these drugs should also be considered. 2020-04-23
Novel Coronavirus: Current Understanding of Clinical Features, Diagnosis, Pathogenesis, and Treatment Options. Symptoms of COVID-19 include fever (88%), cough (68%), vomiting (5%) and diarrhoea (3.7%), and transmission of SARS-CoV-2 is thought to occur from human to human via respiratory secretions released by the infected individuals when coughing and sneezing. […] The purpose of this review is to provide a comprehensive update on the pathogenesis, clinical aspects, diagnosis, challenges and treatment of SARS-CoV-2 infections. 2020-05-29
[Explore the Optimal Resolvent of Medical Needs and Mental Health for Patients with Lung Cancer during Epidemic Novel Coronavirus Pneumonia]. Nearly one third of patients developed new symptoms or exacerbation of existing symptoms. 2020-05-16
[Clinical Characteristics and Coping Strategies of Neoplasms with 2019 Novel Coronavirus Infection]. With comprehensive analysis of relevant literature, this paper reviews the clinical characteristics of neoplastic patients with COVID-19, and puts forward some suggestions on how to deal with this epidemic. 2020-04-24
Systematic rapid “living” review on rehabilitation needs due to covid-19: update to march 31st 2020. Four of them are “calls for action”, 3 provide recommendations about rehabilitation interventions in the acute phase, 2 address the needs of people quarantined at home or with restricted mobility due to the lockdown, and 1 provides a Core Outcome Set to be used in clinical trials to test the efficacy of health strategies in managing Covid-19 patients. 2020-04-22
Coronavirus Disease 2019 Pandemic: Health System and Community Response to a Text Message (Text4Hope) Program Supporting Mental Health in Alberta. Each subscriber receives free daily supportive text messages, for 3 months, crafted by a team of clinical psychologists, psychiatrists, mental health therapist, and mental health service users. 2020-05-07
Coronavirus disease (COVID-19): a scoping review. However, they lack diversity and are almost non-existent in some study fields, such as clinical research. […] The findings suggest that evidence for the development of clinical practice guidelines and public health policies will be improved when more results from clinical research becomes available. 2020-04-24
Coronavirus Disease 2019 Pneumonia in Immunosuppressed Renal Transplant Recipients: A Summary of 10 Confirmed Cases in Wuhan, China. To evaluate the clinical features and outcomes of COVID-19 pneumonia in kidney transplant recipients. […] The clinical outcomes (the severity of pneumonia, recovery rate, time of virus shedding, and length of illness) were compared with the control group by statistical analysis. […] The clinical symptomatic, laboratory, and radiological characteristics of COVID-19 pneumonia in the renal transplant recipients were similar to those of severe COVID-19 pneumonia in the general population. […] Kidney transplant recipients had more severe COVID-19 pneumonia than the general population, but most of them recovered after a prolonged clinical course and virus shedding. 2020-05-28
Clinical features and multidisciplinary treatment outcome of COVID-19 pneumonia: A report of three cases. Our experience highlights the importance of the use of a multidisciplinary therapeutic approach that tailors to the specific condition of the patient in achieving a favorable clinical outcome. 2020-04-24
A sporadic COVID-19 pneumonia treated with extracorporeal membrane oxygenation in Tokyo, Japan: A case report. While clinical reports from China to date demonstrate that the majority of cases remain relatively mild and recover with supportive care, it is also crucial to be well prepared for severe cases warranting intensive care. 2020-04-24
Viral load dynamics and disease severity in patients infected with SARS-CoV-2 in Zhejiang province, China, January-March 2020: retrospective cohort study. Epidemiological, clinical, and laboratory characteristics and treatment and outcomes data were obtained through data collection forms from electronic medical records, and the relation between clinical data and disease severity was analysed. 3497 respiratory, stool, serum, and urine samples were collected from patients after admission and evaluated for SARS-CoV-2 RNA viral load. 2020-04-24
Early Description of Coronavirus 2019 Disease in Kidney Transplant Recipients in New York. Although immunosuppressed individuals are thought to be at an increased risk of severe disease, little is known about their clinical presentation, disease course, or outcomes. […] We report 15 kidney transplant recipients from the Columbia University kidney transplant program who required hospitalization for confirmed COVID-19, and describe their management, clinical course, and outcomes. 2020-05-30
Effect of COVID-19 related lockdown on ophthalmic practice and patient care in India: Results of a survey. Of those who were still examining patients, 82.9% (287/347) were only seeing emergency cases, based on their own clinical judgement. 2020-04-27
Extracorporeal Membrane Oxygenation in the Treatment of Severe Pulmonary and Cardiac Compromise in COVID-19: Experience with 32 patients. The purpose of this manuscript is to review our initial clinical experience in 32 patients with confirmed COVID-19 treated with ECMO.A multi-institutional registry and database was created and utilized to assess all patients who were supported with ECMO provided by SpecialtyCare. […] Additional patient experience and associated clinical and laboratory data must be obtained to further define the optimal role of ECMO in patients with COVID-19 and ARDS. 2020-05-15
[COVID-19 in hospitalized children and adolescents]. The clinical knowledge about the course, complications and treatment of COVID-19 in children and adolescents is so far limited. […] This systematic review summarizes the current scientific evidence regarding the clinical presentation of COVID-19 in hospitalized children based on available case series from China. […] Most commonly reported symptoms were fever and cough; in 40-100% of cases involvement of the lower respiratory tract was reported, usually confirmed by computed tomography (CT). 2020-04-24
Understanding SARS-CoV-2: Genetic Diversity, Transmission and Cure in Human. Hence, the experiences from the clinical intervention for that region should be considered in control and treatment strategies. 2020-04-24
The clinical data from 19 critically ill patients with coronavirus disease 2019: a single-centered, retrospective, observational study. The objectives of this study were to analyze the clinical features of coronavirus disease 2019 (COVID-19) and evaluate the diagnosis and treatment. […] A retrospective analysis of the clinical manifestation and auxiliary examination of 19 patients with COVID-19 from the Liyuan Hospital intensive care unit (ICU) between January 16, 2020 and February 20, 2020 was undertaken. […] The clinical laboratory indices change significantly, especially the D-dimer level among non-survivors. 2020-04-24
Potential therapeutic effects of dipyridamole in the severely ill patients with COVID-19. Effective antivirals with safe clinical profile are urgently needed to improve the overall prognosis. […] In a proof-of-concept trial involving 31 patients with COVID-19, DIP supplementation was associated with significantly decreased concentrations of D-dimers (P<0.05), increased lymphocyte and platelet recovery in the circulation, and markedly improved clinical outcomes in comparison to the control patients. […] In particular, all 8 of the DIP-treated severely ill patients showed remarkable improvement: 7 patients (87.5%) achieved clinical cure and were discharged from the hospitals while the remaining 1 patient (12.5%) was in clinical remission. 2020-04-24
Age-related rhesus macaque models of COVID-19. Three 3-5 years old and two 15 years old rhesus macaques were intratracheally infected with SARS-CoV-2, and then analyzed by clinical signs, viral replication, chest X-ray, histopathological changes and immune response. 2020-05-19
Epidemiological and clinical characteristics of 26 asymptomatic SARS-CoV-2 carriers. Epidemiological and clinical characteristics from the 26 asymptomatic patients with positive results for SARS-CoV-2 RNA testing were obtained. 2020-04-30
Multicenter initial guidance on use of antivirals for children with COVID-19/SARS-CoV-2. Antivirals should preferably be used as part of a clinical trial if available. 2020-05-14
Imaging characteristics of initial chest computed tomography and clinical manifestations of patients with COVID-19 pneumonia. To investigate the chest CT imaging characteristics and clinical manifestations of patients with COVID-19 pneumonia. […] This study included 150 patients with COVID-19 pneumonia diagnosed from January 10 to February 12, 2020 to analyze their clinical and CT imaging characteristics. 2020-05-29
The Effect of COVID-19 on Youth Mental Health. The results of this cross-sectional study suggest that nearly 40.4% the sampled youth were found to be prone to psychological problems and 14.4% the sampled youth with Post-traumatic stress disorder (PTSD) symptoms. 2020-05-08
Two X-linked agammaglobulinemia patients develop pneumonia as COVID-19 manifestation but recover. The recent SARS-CoV-2 pandemic, which has recently affected Italy since February 21, constitutes a threat to normal subjects, as the coronavirus disease-19 (COVID-19) can manifest with a broad spectrum of clinical phenotypes ranging from asymptomatic cases to pneumonia or even death. […] When the SARS-CoV-2 epidemic has reached Italy, we have activated a surveillance protocol of patients with IEI, to perform SARS-CoV-2 search by nasopharyngeal swab in patients presenting with symptoms that could be a manifestation of COVID-19, such as fever, cough, diarrhea, or vomiting. 2020-05-19
Managing childhood allergies and immunodeficiencies during respiratory virus epidemics - the 2020 COVID-19 pandemic. At the current stage of knowledge, children have less severe symptoms of COVID-19, and severe asthma and immunodeficiency are classified as risk factors. 2020-05-20
Successful containment of Covid-19 outbreak in a large maternity and perinatal center while continuing clinical service. At the same time, clinical services could be maintained, however, not without deployment of personnel exposed to employees infected with SARS-CoV-2. […] Apart from massive testing of personnel in pre-defined phases and increased hygiene measures, including a general obligation to wear surgical face masks, we identified the need to monitor cases of illness across all groups of employees, to ensure social distancing within personnel and to evaluate contacts of clinical personnel outside of the hospital environment, in order to be able to interpret chains of infections and to disrupt them. 2020-05-18
A Case of SARS-CoV-2-pneumonia with successful antiviral therapy in a 77-year-old male with heart transplant. In this report, we present a 77-year old patient with a heart transplant under relevant immunosuppressive therapy who was tested positive for SARS-CoV-2 after several days of dyspnoea, dry cough and light general symptoms. […] The patient received an antiviral therapy with hydroxychloroquine showing no further deterioration of the clinical state. 2020-04-22
[CoViD-19: we knew everything but we didn’t understand anything.] Above all, this pandemic force us to review what is essential and really necessary in term of priorities and regulatory process for clinical pharmacological research. […] However, several clinical centres decided to use off label drugs as a standard of care in the absence of efficacy and safety data. […] The lessons we will learn from this emergency may result crucial in redesigning a better way of conducting clinical trials and information on drugs. 2020-04-24
[The cure: a question of merit?] We still do not have clear what positive criteria can help make clinical decisions in contexts of insufficient resources that force us to make choices. 2020-04-24
[Ethical, deontologic and legal considerations about SIAARTI Document “Clinical ethics recommendations for the allocation of intensive care treatments, in exceptional, resource-limited circumstances”.] On 6 March 2020, the Italian Society of Anaesthesia Analgesia Resuscitation and Intensive care (SIAARTI) published the document “Clinical Ethics Recommendations for Admission to and Suspension of Intensive Care in Exceptional Conditions of Imbalance between Needs and Available Resources”. 2020-04-24
[Between intensive care and palliative care at the time of CoViD-19.] They have to apply specific clinical and ethical criteria, in emergency conditions. […] The clinical criteria should include the disease severity, the number and severity of comorbidities, frailty, the organ failures and their stage, the patient’s age, the functional autonomy and cognitive status. […] The patients not admitted to ICU due to clinical reasons and advanced stage diseases should receive a high quality palliative care, to obtain a good symptoms control (mainly dyspnea, anxiety and delirium) and to implement palliative sedation at the end of life. 2020-04-24
[It’s world war at CoViD-19. The first battle on the front of the viral invasion against the exitus for interstitial pneumonia was decisive.] The clinical spectrum of this infection includes, in order of lesser to greater severity, asymptomatic viremia, paucisymptomatic forms, clinical conditions characterized by respiratory failure that needs mechanical ventilation and support in an intensive care unit, systemic manifestations of infection, septic shock, and multiple organ dysfunction syndromes. […] Starting from the pathogenetic mechanisms involved in the development of this infection up to the clinical characteristics of the infected patients, in this review we tried to focus on the crucial points of the infection in combination with the appropriateness of the medical intervention. […] We aim to offer indications of therapeutic intervention that are timely and, as far as possible, effective, targeted to the individual patient in relation to age, clinical condition and comorbidities. 2020-04-24
Anosmia as a prominent symptom of COVID-19 infection. Therefore, identifying the early symptoms of COVID-19 is of particular importance and is a health system priority. […] Early studies from COVID-19 outbreak in China have illustrated several non-specific signs and symptoms in infected patients, including fever, dry cough, dyspnea, myalgia, fatigue, lymphopenia, and radiographic evidence of pneumonia (3, 4). 2020-04-22
Presenting Characteristics, Comorbidities, and Outcomes Among 5700 Patients Hospitalized With COVID-19 in the New York City Area. To describe the clinical characteristics and outcomes of patients with COVID-19 hospitalized in a US health care system. […] Clinical outcomes during hospitalization, such as invasive mechanical ventilation, kidney replacement therapy, and death. 2020-05-01
Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infection in Children and Adolescents: A Systematic Review. All articles reflected research performed in China, except for 1 clinical case in Singapore. […] Children at any age were mostly reported to have mild respiratory symptoms, namely fever, dry cough, and fatigue, or were asymptomatic. […] To our knowledge, this is the first systematic review that assesses and summarizes clinical features and management of children with SARS-CoV-2 infection. […] The rapid spread of COVID-19 across the globe and the lack of European and US data on pediatric patients require further epidemiologic and clinical studies to identify possible preventive and therapeutic strategies. 2020-04-22
Potential of live pathogen vaccines for defeating the COVID-19 pandemic: history and mechanism. The safety and efficacy of this strategy should be investigated strictly using animal experiments and clinical trials, and even if the experiments and trials all support the strategy, it should be implemented with enough cautiousness. 2020-04-22
The emergence of a novel coronavirus (SARS-CoV-2) disease and their neuroinvasive propensity may affect in COVID-19 patients. SARS-CoV-2 shares highly homological sequences with SARS-CoVs causing highly lethal pneumonia with respiratory distress and clinical symptoms similar to those reported for SARS-CoV and MERS-CoV infections. 2020-04-29
Co-detection of respiratory pathogens in patients hospitalized with Coronavirus viral disease-2019 pneumonia. Clinical, laboratory and imaging characteristics of Coronavirus disease 2019 (Covid-19) and risk factors associated with poor outcomes have been reported in various studies.1-2 Nevertheless, information on whether other respiratory pathogens (RP) were co-detected in patients in these series was not provided, despite the fact that coinfections with RP have been reported to occur in this clinical setting.3-6 This article is protected by copyright. 2020-04-22
Logic in the time of coronavirus. We need to use contemporary methods of assessing causality to ensure that clinical, laboratory and public health measures draw on a rational, evidence-based approach to argumentation. 2020-05-29
Chloroquine Dosing Recommendations for Pediatric COVID-19 Supported by Modeling and Simulation. The knowledge-driven, model-informed dose selection paradigm can serve as a science-based alternative to recommend pediatric dosing when pediatric clinical trial data is absent. 2020-05-21
Scientific research progress of COVID-19/SARS-CoV-2 in the first five months. Here, we summarized the current known knowledge regarding epidemiological, pathogenesis, pathology, clinical features, comorbidities and treatment of COVID-19/ SARS-CoV-2 as reference for the prevention and control COVID-19. 2020-05-07
Complex Immune Dysregulation in COVID-19 Patients with Severe Respiratory Failure. The sudden clinical deterioration 7-8 days after initial symptom onset suggests that severe respiratory failure (SRF) in COVID-19 is driven by a unique pattern of immune dysfunction. 2020-04-24
Recent progress and challenges in drug development against COVID-19 coronavirus (SARS-CoV-2) - an update on the status. Favilavir is an antiviral drug that is approved in Japan for common influenza treatment and is now approved to treat symptoms of COVID-19 in China. […] The first COVID-19 vaccine is not expected to be ready for clinical trials before the end of the year. 2020-05-26
Déjà vu: Stimulating open drug discovery for SARS-CoV-2. In the COVID-19 pandemic, despite being a new virus, there are already drugs suggested as active in in vitro assays that are being repurposed in clinical trials. 2020-04-29
COVID-19 Diagnostic and Management Protocol for Pediatric Patients. This review aims to verify the main epidemiologic, clinical, laboratory-related, and therapeutic aspects of coronavirus disease 2019 (COVID-19) in critically ill pediatric patients. […] The report emphasizes on the clinical presentations of the disease and ventilatory support in pediatric patients with COVID-19. […] COVID-19 is essentially an unknown clinical condition for the majority of pediatric intensive care professionals. 2020-04-27
Management of inflammatory bowel disease patients in the COVID-19 pandemic era: a Brazilian tertiary referral center guidance. The world is fighting the COVID-19 outbreak and health workers, including inflammatory bowel diseases specialists, have been challenged to address the specific clinical issues of their patients. […] We hereby summarize the current literature in the management of inflammatory bowel disease (IBD) patients during the COVID-19 pandemic era that support the rearrangement of our IBD unit and the clinical advice provided to our patients. 2020-04-27
COVID-19 and what pediatric rheumatologists should know: a review from a highly affected country. The spectrum of respiratory symptoms may range from mild to severe, strictly depending on the age of the patient and the underlying comorbidities.In children COVID-19 related disease is less frequent and less aggressive. 2020-04-24
Is GSK3β a molecular target of chloroquine treatment against COVID-19? The recent clinical trial reports pertaining to the efficacy of chloroquine and hydroxychloroquine against COVID-19 albeit yet to be validated with larger clinical trials, have sparked much interest globally to evaluate whether this anti-malarial drug can be repurposed for the treatment of COVID-19. 2020-05-08
A practice of anesthesia scenario design for emergency cesarean section in patients with COVID-19 infection based on the role of standard patient. In this article, we give a practice of anesthesia scenario design for emergency cesarean section in a supposed standard patient suffering COVID-19, aimed to optimize the work flow and implement the protective details through simulation of a real operation scenario, which may be useful for training and clinical practice of anesthesia management for patients suffering COVID-19 or other fulminating infectious diseases. 2020-04-23
Asymptomatic carriers of COVID-19 as a concern for disease prevention and control: more testing, more follow-up. However, asymptomatic carriers will not be included in confirmed cases unless they develop clinical manifestations while in quarantine. 2020-04-23
Neuropsychiatric adverse events of chloroquine: a real-world pharmacovigilance study using the FDA Adverse Event Reporting System (FAERS) database. Although infrequent, neuropsychiatric symptoms have been reported in patients who received chloroquine for the treatment of malaria or autoimmune diseases. 2020-05-22
Modelling the COVID-19 epidemic and implementation of population-wide interventions in Italy. Our SIDARTHE model discriminates between infected individuals depending on whether they have been diagnosed and on the severity of their symptoms. 2020-05-01
SARS-CoV-2 Infection in Pregnancy - a Review of the Current Literature and Possible Impact on Maternal and Neonatal Outcome. Based on the literature available at the moment, it can be assumed that the clinical course of COVID-19 disease may be complicated by pregnancy which could be associated with a higher mortality rate. 2020-04-26
[Coronavirus pandemic-Memories of the flu epidemic from 1918 from a gynecological and obstetric perspective]. The symptoms, course and outcome all seem to show parallels. 2020-04-23
Aerosolization of COVID-19 and Contamination Risks During Respiratory Treatments. We have expanded on non-US public health recommendations to provide guidance to frontline HCWs to enhance collaboration between clinicians, who are often siloed in their clinical practices, and ultimately to protect the federal workforce, which cannot sustain a significant loss of frontline HCWs. 2020-04-26
COVID-19 and intracerebral haemorrhage: causative or coincidental? The limited clinical data about the virus’s behavior to date, especially extrapulmonary symptoms, suggest that we should be aware of the possibility of initial cerebrovascular manifestations of COVID-19. 2020-04-26
Epidemiology, genome, and clinical features of the pandemic SARS-CoV-2: a recent view. Most infected individuals are asymptomatic or only exhibit mild symptoms. […] After the incubation period, the most common symptoms are fever, cough and fatigue. 2020-04-26
Novel coronavirus disease (COVID-19): a pandemic (epidemiology, pathogenesis and potential therapeutics). However, in clinical trials, few broad-spectrum antiviral drugs were evaluated against COVID-19 infection which resulted in clinical recovery. 2020-05-30
Review on the global epidemiological situation and the efficacy of chloroquine and hydroxychloroquine for the treatment of COVID-19. Clinical trials are currently underway. 2020-04-26
Efficacy of glutathione therapy in relieving dyspnea associated with COVID-19 pneumonia: A report of 2 cases. No published treatment to date has been shown to adequately control the inflammation and respiratory symptoms associated with COVID-19, apart from oxygen therapy and assisted ventilation. […] Repeated use of both 2000 mg of PO and IV glutathione was effective in further relieving respiratory symptoms. 2020-04-25
The emergence of SARS, MERS and novel SARS-2 coronaviruses in the 21st century. In sum, SARS, MERS and COVID-19 are caused by recently discovered coronaviruses that cause flu-like illnesses, but with a clinical outcome that tends to be more severe. 2020-05-01
Chloroquine and Hydroxychloroquine for the Prevention or Treatment of Novel Coronavirus Disease (COVID-19) in Africa: Caution for Inappropriate Off-Label Use in Healthcare Settings. Although there are ongoing clinical trials of repurposed and investigational antiviral and immune-based therapies, there are as yet no scientifically proven, clinically effective pharmacological treatments for COVID-19. […] Among the repurposed drugs, the commonly used antimalarials chloroquine (CQ) and hydroxychloroquine (HCQ) have become the focus of global scientific, media, and political attention despite a lack of randomized clinical trials supporting their efficacy. 2020-04-23
Medical genetics education in the midst of the COVID-19 pandemic: Shared resources. Our history of agility in learning and teaching is now only inhibited by the time constraints of current clinical demands on the genetics community. 2020-05-29
Rapid and Sensitive Detection of anti-SARS-CoV-2 IgG, Using Lanthanide-Doped Nanoparticles-Based Lateral Flow Immunoassay. The results of the validation experiment met the requirements for clinical diagnostic reagents. 2020-05-21
Association of Renin-Angiotensin System Inhibitors With Severity or Risk of Death in Patients With Hypertension Hospitalized for Coronavirus Disease 2019 (COVID-19) Infection in Wuhan, China. COVID-19 was confirmed by real-time reverse transcription-polymerase chain reaction and epidemiologic, clinical, radiologic, laboratory, and drug therapy data were analyzed in all patients. […] This study provides clinical data on the association between ACEIs/ARBs and outcomes in patients with hypertension hospitalized with COVID-19 infections, suggesting that ACEIs/ARBs are not associated with the severity or mortality of COVID-19 in such patients. 2020-04-30
Essential new informations for the clinical recognition of COVID-19 infection and the prevention possibilities of healthcare personnel working in the head and neck region The current article is a literature review, in which the authors elaborated the recently available scientific articles with their relevancy for clinical interventions as primary factor. 2020-04-27
Diagnostic consideration and bedside estimation of the prognosis in COVID-19 patients We detail the relevant anamnestic factors and initial examination results which serve as basics for the clinical suspicion of COVID-19. 2020-04-27
Practical aspects of intensive care for critically ill COVID-19 patients requiring respiratory support This viral disease (COVID-19) can appear in a variety of forms, from asymptomatic through the spectrum of mild symptoms to severe respiratory failure, requiring intensive care. 2020-04-27
COVID-19 safety in maternity care: lessons for the whole NHS. John Tingle, Lecturer in Law, Birmingham Law School, University of Birmingham, discusses some recent reports in maternity care, which can be seen to also to have general application across all clinical specialities. 2020-04-27
Restructuring Electrophysiology During the COVID-19 Pandemic: A Practical Guide from a New York City Hospital Network. With regard to cardiac electrophysiology (EP) services, we discuss the “real-world” challenges and solutions that have been essential for efficient and successful (i) ramping down of standard clinical practice patterns and (ii) pivoting of workflow processes to meet the demands of this pandemic. […] The aims of these recommendations are to outline: (1) essential practical steps to approaching procedures, as well as outpatient and inpatient care of EP patients, with relevant examples, (2) successful strategies to minimize exposure risk to patients and clinical staff while also balancing resource utilization, (3) challenges related to redeployment and restructuring of clinical and support staff, and (4) considerations regarding continued collaboration with clinical and administrative colleagues in order to implement these changes. 2020-04-30
The Change to Pass/Fail Scoring for Step 1 in the Context of COVID-19: Implications for the Transition to Residency Process. The COVID-19 pandemic is dominating the educational and clinical environments and is now the biggest disruptor in all aspects of life, not just medical education. 2020-05-02
Radiological Society of North America Expert Consensus Statement on Reporting Chest CT Findings Related to COVID-19. Endorsed by the Society of Thoracic Radiology, the American College of Radiology, and RSNA. Consultation with clinical colleagues at each institution is suggested to establish a consensus reporting approach. 2020-05-30
The profile of peripheral blood lymphocyte subsets and serum cytokines in children with 2019 novel coronavirus pneumonia. The adaptable change in IL-10 level might contribute to the relatively mild pneumonia symptoms in children with 2019-nCoV pneumonia and bacterial co-infection might be a risk factor of severe 2019-nCoV pneumonia. 2020-05-06
Characteristics, Symptom Management, and Outcomes of 101 Patients With COVID-19 Referred for Hospital Palliative Care. Most prevalent symptoms (n) were breathlessness (67), agitation (43), drowsiness (36), pain (23), and delirium (24). 2020-05-11
COVID-19 pathophysiology: A review. Epidemiological studies showed that elder patients were more susceptible to severe diseases, while children tend to have milder symptoms. 2020-05-31
Chest CT findings of COVID-19 pneumonia by duration of symptoms. To evaluate lung abnormalities on thin-section computed tomographic (CT) scans in patients with COVID-19 and correlate findings to duration of symptoms. […] In total, 348 CT scans in 112 patients were classified according to the time after the onset of the initial symptoms, namely stage-1 (0-4 days); stage-2 (5-9 days); stage-3 (10-14 days); stage-4 (15-21 days); stage-5 (22-28 days); and stage-6 (>28 days). 2020-05-15
Generalized anxiety disorder, depressive symptoms and sleep quality during COVID-19 outbreak in China: a web-based cross-sectional survey. Using a web-based cross-sectional survey, we collected data from 7,236 self-selected volunteers assessed with demographic information, COVID-19 related knowledge, generalized anxiety disorder (GAD), depressive symptoms, and sleep quality. […] The overall prevalence of GAD, depressive symptoms, and sleep quality of the public were 35.1%, 20.1%, and 18.2%, respectively. […] Younger people reported a significantly higher prevalence of GAD and depressive symptoms than older people. 2020-05-19
A Novel Reverse Transcription Loop-Mediated Isothermal Amplification Method for Rapid Detection of SARS-CoV-2. To evaluate the viability of the assay, a comparison between the RT-LAMP and a commercial RT-qPCR assay was made using 56 clinical samples. 2020-04-27
COVID-19 Drug Discovery Using Intensive Approaches. While novel vaccines and drugs that target SARS-CoV-2 are under development, this review provides information on therapeutics which are under clinical trials or are proposed to antagonize SARS-CoV-2. […] Since several antiviral therapies can inhibit viral replication cycles or relieve symptoms, mechanisms unique to RNA viruses will be important for the clinical development of antivirals against SARS-CoV-2. 2020-04-27
COVID-19: A Recommendation to Examine the Effect of Mouthrinses with β-Cyclodextrin Combined with Citrox in Preventing Infection and Progression. We urge national agencies and authorities to start clinical trials to evaluate the preventive effects of βCD-Citrox therapeutic oral biofilm rinses in reducing the viral load of the infection and possibly disease progression. 2020-05-23
From Donor to Patient: Collection, Preparation and Cryopreservation of Fecal Samples for Fecal Microbiota Transplantation. Technical and logistical issues arise when establishing such a non-standardized treatment into clinical practice with safety and proper governance. […] In this context, our manuscript describes a process of donor safety screening for FMT compiling clinical and biological examinations, questionnaires and interviews of donors. 2020-04-24
Sexual and reproductive health (SRH): a key issue in the emergency response to the coronavirus disease (COVID- 19) outbreak. The novel coronavirus (SARS-CoV-2) is new to humans, and only limited scientific evidence is available to identify the impact of the disease COVID-19 on SRH, including clinical presentation and outcomes of the infection during pregnancy, or for persons with STI/HIV-related immunosuppression. […] Beyond the clinical scope of SRH, we should not neglect the impacts at the health system level and disruptions or interruptions in regular provision of SRH services, such as pre- and postnatal checks, safe abortion, contraception, HIV/AIDS and sexually transmitted infections. […] Therefore, there is an urgent need for the scientific community to generate sound clinical, epidemiological, and psycho-social behavioral links between COVID-19 and SRH and rights outcomes. 2020-04-27
Renal histopathological analysis of 26 postmortem findings of patients with COVID-19 in China. Nine of the 26 showed clinical signs of kidney injury that included increased serum creatinine and/or new-onset proteinuria. 2020-05-13
CT characteristics of patients infected with 2019 novel coronavirus: association with clinical type. The clinical information and chest CT images of 93 patients infected with 2019-nCov from multiple centres were reviewed. […] The CT and clinical appearances of COVID-19 are variable and reflect the severity of COVID-19 to some extent. 2020-05-12
Safety signals for QT prolongation or Torsades de Pointes associated with azithromycin with or without chloroquine or hydroxychloroquine. Combinations of hydroxychloroquine (HCQ) and azithromycin have been promoted as treatments for COVID-19 based on small, uncontrolled clinical trials that have not assessed potential risks. 2020-04-27
Keeping people with epilepsy safe during the Covid-19 pandemic. The first was "How should we/clinicians modify our clinical care pathway for people with epilepsy during the COVID-19 pandemic? 2020-04-24
Clinical and virologic characteristics of the first 12 patients with coronavirus disease 2019 (COVID-19) in the United States. Data on the detailed clinical progression of COVID-19 in conjunction with epidemiological and virological characteristics are limited. […] Common symptoms at illness onset were cough (n = 8) and fever (n = 7). […] Patients had mild to moderately severe illness; seven were hospitalized and demonstrated clinical or laboratory signs of worsening during the second week of illness. 2020-04-24
SARS-CoV-2 entry factors are highly expressed in nasal epithelial cells together with innate immune genes. The study offers a useful resource for further lines of inquiry with valuable clinical samples from COVID-19 patients and we provide our data in a comprehensive, open and user-friendly fashion at 2020-05-28
SARS-COV-2 infection (coronavirus disease 2019) for the gastrointestinal consultant. The available reports suggest that gastrointestinal (GI) involvement in coronavirus disease 2019 (COVID-19) is common and in some cases the GI symptoms may precede the respiratory symptoms. […] Many of the medications used for treatment of COVID-19 can also be associated with GI symptoms or liver injury and can be included in the differential diagnosis in these patients. 2020-04-27
Coronavirus (COVID-19): A Review of Clinical Features, Diagnosis, and Treatment. This review will introduce a general overview of coronavirus and describe the clinical features, evaluation, and treatment of COVID-19 patients. […] Furthermore, our review focuses on the most up-to-date clinical information for the effective management, prevention, and counseling of patients worldwide. 2020-04-27
Cardiac Tamponade Secondary to COVID-19. A 67-year-old female presented with upper respiratory symptoms and was diagnosed with COVID-19. […] Clinical course was complicated by development of Takotsubo cardiomyopathy. […] She was treated with pericardiocentesis, colchicine, corticosteroids and hydroxychloroquine with improvement in symptoms. 2020-04-24
Dental care during the coronavirus disease 2019 (COVID-19) outbreak: operatory considerations and clinical aspects. This paper is aimed at addressing the urgent need to develop a protocol that will address the operatory and clinical aspects of dental care during the Coronavirus disease 2019 (COVID-19) outbreak. […] The epidemiology, clinical signs and symptoms, and modes of transmission of COVID-19 are presented. […] This protocol is based on a detailed review of the existing English language literature as well on the logistic and clinical experience of each facility and the opinion of the authors. […] The first part of this review discusses operatory considerations; the second part discusses general dental clinical aspects; the third part discusses endodontic considerations; and the fourth part discusses surgical aspects. […] Logistic and clinical steps are required to provide dental care during the COVID-19 outbreak while preventing cross-contamination and protecting the dental team during the provision of care. 2020-04-27
Guidance for anti-VEGF intravitreal injections during the COVID-19 pandemic. Management of patients with retinal disease receiving intravitreal injections during the COVID-19 pandemic will require adjustment to regular clinical practice to minimize the risk of exposure of patients and healthcare staff, and to prioritize those with the greatest medical need. 2020-05-21
Clinical Pathway for Early Diagnosis of COVID-19: Updates from Experience to Evidence-Based Practice. Clinical features of COVID-19 include high fever, cough, and fatigue which may progress to ARDS. […] The importance of a clinical pathway to implement the most effective and relevant diagnostic strategy is of critical importance to establish the control of this virus that is responsible for more and more deaths each day. 2020-05-08
Study of SARS-CoV-2 in semen and urine samples of a volunteer with positive naso-pharyngeal swab. Although this should be interpreted cautiously, it may be possible that either the viral clearance kinetics in these matrices matches the progressive clinical recovery of the patient or that the virus was never present in these fluids at the time of the laboratory diagnosis. 2020-05-07
Neurological complications of coronavirus and COVID-19. Clinical and experimental studies have shown that the coronavirus family has a certain tropism for the central nervous system. […] Neurological symptoms have been reported in patients affected by COVID-19, such as headache, dizziness, myalgia and anosmia, as well as cases of encephalopathy, encephalitis, necrotising haemorrhagic encephalopathy, stroke, epileptic seizures, rhabdomyolysis and Guillain-Barre syndrome, associated with SARS-CoV-2 infection. 2020-04-28
Self-reported olfactory loss associates with outpatient clinical course in Covid-19. Self-reported olfactory impairment has recently been recognized as a hallmark of Covid-19 and may be an important predictor of clinical outcome. […] A retrospective review of all patients presenting to a San Diego Hospital system with laboratory-confirmed positive Covid-19 infection was conducted with evaluation of olfactory and gustatory function and clinical disease course. […] Smell loss in Covid-19 may associate with a milder clinical course. 2020-04-24
Fibrinolytic abnormalities in acute respiratory distress syndrome (ARDS) and versatility of thrombolytic drugs to treat COVID-19. In this review, we discuss the repurposing of fibrinolytic drugs, namely tissue-type plasminogen activator (tPA), to treat COVID-19 associated ARDS. tPA is an approved intravenous thrombolytic treatment, and the nebulizer form has been shown to be effective in plastic bronchitis and is currently in Phase II clinical trial. 2020-04-24
[An analysis of global research on SARS-CoV-2]. All articles were categorized into epidemiology, clinical diagnosis and treatment, basic research, pregnant women and children, mental health, epidemic prevention & control, and others. 2020-04-27
Andrographolide as a potential inhibitor of SARS-CoV-2 main protease: an in silico approach. The clinical trials are underway for Remdesivir, an investigational anti-viral drug from Gilead Sciences. 2020-05-14
Current pharmacological treatments for COVID-19: What’s next? Where available, data from clinical trials involving patients with COVID-19 are reported. […] Preliminary clinical trials seem to support their benefit. […] Thus, adequate clinical trials are necessary for these compounds. […] Nevertheless, while waiting for effective preventive measures i.e. vaccines, many clinical trials on drugs belonging to different therapeutic classes are currently underway. […] Their results will help us in defining the best way to treat COVID-19 and reducing its symptoms and complications. 2020-05-16
Role of Telehealth in the Management of COVID-19: Lessons Learned from Previous SARS, MERS, and Ebola Outbreaks. In order to better control the rapid spread of coronavirus and manage the COVID-19 crisis, both developed and developing countries can improve the efficiency of their health system by replacing a proportion of face-to-face clinical encounters with telehealth. 2020-04-24
Neutrophil extracellular traps in COVID-19. Highlighting the potential clinical relevance of these findings, cell-free DNA strongly correlated with acute phase reactants including C-reactive protein, D-dimer, and lactate dehydrogenase, as well as absolute neutrophil count. 2020-05-29
SARS-CoV-2 causing pneumonia-associated respiratory disorder (COVID-19): diagnostic and proposed therapeutic options. In this crisis, a collective pool of knowledge about the advancement of clinical diagnostic and management for COVID-19 is a prerequisite. […] Moreover, the review discusses different aspects of the COVID-19, including its epidemiology; incubation period; the general clinical features of patients; the clinical features of intensive care unit (ICU) patients; SARS-CoV-2 infection in the presence of co-morbid diseases and the clinical features of pediatric patients infected with the SARS-CoV-2. 2020-04-30
Acute urticaria with pyrexia as the first manifestations of a COVID-19 infection. The coronavirus disease 2019 (COVID-19) affects principally the respiratory tract but recent studies described that COVID-19 could present a broader clinical spectrum from the absence of any symptoms to heart 1 , digestive 2 or Ear-Nose-Throat (including anosmia and ageusia) 3 manifestations. 2020-04-24
The care of patients with Duchenne, Becker, and other muscular dystrophies in the COVID-19 pandemic. The coronavirus disease 2019 (COVID-19) pandemic has resulted in the reorganization of health-care settings affecting clinical care delivery to patients with Duchenne and Becker muscular dystrophy (DBMD) as well as other inherited muscular dystrophies. […] We address issues surrounding corticosteroid and exon-skipping treatments, cardiac medications, hydroxychloroquine use, emergency/respiratory care, rehabilitation management, and the conduct of clinical trials. 2020-05-05
Spinal muscular atrophy care in the COVID-19 pandemic era. The coronavirus disease 2019 (COVID-19) pandemic has resulted in reorganization of healthcare settings affecting the delivery of clinical care to patients with spinal muscular atrophy (SMA). […] There is a concern that patients with SMA may be at increased risk of manifesting severe symptoms of COVID-19. 2020-05-06
Tracheostomy protocols during COVID-19 pandemic. Articles reporting clinical practice guidelines for tracheostomy in the context of COVID-19 were included. 2020-05-29
Early institutional head and neck oncologic and microvascular surgery practice patterns across the United States during the SARS-CoV-2 (COVID19) pandemic. Factors contributing to reduced clinical volume included lack of personal protective equipment (PPE) (35%) and lack of rapid COVID-19 testing (86%). 2020-05-29
Tracheostomy guidelines developed at a large academic medical center during the COVID-19 pandemic. This study is a multidisciplinary review of institutional tracheostomy guidelines and clinical pathways. […] Modifications to support clinical decision making in the context of COVID-19 were derived by consensus and available evidence. 2020-05-29
Presymptomatic SARS-CoV-2 Infections and Transmission in a Skilled Nursing Facility. Symptoms that had been present during the preceding 14 days were recorded. […] Residents with SARS-CoV-2 infection were categorized as symptomatic with typical symptoms (fever, cough, or shortness of breath), symptomatic with only atypical symptoms, presymptomatic, or asymptomatic. […] Of these 48 residents, 27 (56%) were asymptomatic at the time of testing; 24 subsequently developed symptoms (median time to onset, 4 days). 2020-05-29
A retrospective study of risk factors for severe acute respiratory syndrome coronavirus 2 infections in hospitalized adult patients. The aim of the study was to identify the clinical characteristics and risk factors associated with severe incidence of SARS ‑CoV‑2 infection. 2020-05-29
COVID-19 Lung Injury and High Altitude Pulmonary Edema: A False Equation with Dangerous Implications. Despite some similarities in clinical features between the two entities, such as hypoxemia, radiographic opacities and altered lung compliance, the pathophysiological mechanisms of HAPE and lung injury due to COVID-19 are fundamentally different and the entities cannot be viewed as equivalent. 2020-04-24
Dental Care and Oral Health under the Clouds of COVID-19. Oral symptoms are prominent before fever and cough occur. 2020-04-24
A precision medicine approach to managing 2019 novel coronavirus pneumonia. The clinical features of the infection are not specific and are often indistinguishable from those of other respiratory infections, making it difficult to diagnose. 2020-04-27
Effect of High vs Low Doses of Chloroquine Diphosphate as Adjunctive Therapy for Patients Hospitalized With Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infection: A Randomized Clinical Trial. This parallel, double-masked, randomized, phase IIb clinical trial with 81 adult patients who were hospitalized with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection was conducted from March 23 to April 5, 2020, at a tertiary care facility in Manaus, Brazilian Amazon. […] Secondary end points included participant clinical status, laboratory examinations, and electrocardiogram results. 2020-04-29
A systematic scoping review of COVID-19 during pregnancy and childbirth. Clinical presentation and outcomes of COVID-19 infection during pregnancy remain limited and fragmented. […] To summarize the existing literature on COVID-19 infection during pregnancy and childbirth, particularly concerning clinical presentation and outcomes. […] A descriptive summary organized by aspects of clinical presentations (symptoms, imaging, and laboratory) and outcomes (maternal and perinatal). […] COVID-19 infection during pregnancy probably has a clinical presentation and severity resembling that in non-pregnant adults. 2020-05-18
Protecting vulnerable patients with inherited anaemias from unnecessary death during the COVID-19 pandemic. Blood transfusion programmes should be continued, but specific changes to usual clinical pathways can be instituted to reduce risk of patient exposure to COVID-19, as well as contingency planning for possible reductions in blood available for transfusions. 2020-05-19
Persistent viral RNA positivity during recovery period of a patient with SARS-CoV-2 infection. As an emerging infectious disease, the clinical course and virological course of SARS-CoV-2 infection remain to be further investigated. […] In this case report, we described a case of SARS-CoV-2 infection with clinical course more than two months. […] In conclusion, these findings indicate that SARS-CoV-2 can cause a long clinical course. 2020-04-24
Optimization of group size in pool testing strategy for SARS-CoV-2: A simple mathematical model. It is best implemented in subgroups with low clinical suspicion. 2020-05-03
Characteristics of patients with coronavirus disease (COVID-19) confirmed using an IgM-IgG antibody test. Clinical and laboratory data were collected and analyzed. 2020-05-08
SARS-CoV-2 can be detected in urine, blood, anal swabs, and oropharyngeal swabs specimens. The purpose of this study was to detect severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) ribonucleic acid (RNA) in urine and blood specimens, and anal and oropharyngeal swabs from patients with confirmed SARS-CoV-2 infection, and correlated positive results with clinical findings. […] Patients’ demographic and clinical data were recorded. […] The presence of viral RNA was not necessarily predictive of clinical symptoms, for example, the presence of viral RNA in the urine did not necessarily predict urinary tract symptoms. 2020-05-05
Asymptomatic COVID-19 infection in late pregnancy indicated no vertical transmission. This study is to investigate the clinical characteristics of late pregnancy with asymptomatic 2019 novel coronavirus disease (COVID-19) infection, evaluate the outcome of maternal and fetal prognosis, and identify the evidence of intrauterine vertical transmission. […] Clinical data including laboratory test results and chest computed tomography (CT) scanning were collected and reviewed. […] We reported an asymptomatic COVID-19 pregnant woman with detailed clinical information and our result indicated that for late pregnant women with asymptomatic COVID-19 infection, there might be no intrauterine infection caused by vertical transmission. 2020-04-30
Learning At-Home During COVID-19: A Multi-institutional Virtual Learning Collaboration. Given the cancellation of all elective procedures with the COVID-19 crisis, many anesthesiology learners are assigned to stay at home, limiting opportunities to learn in the clinical environment. 2020-04-24
COVID-19 in solid organ transplant recipients: Initial report from the US epicenter. Baseline characteristics, clinical presentation, antiviral and immunosuppressive management were compared between patients with mild/moderate and severe disease (defined as ICU admission, intubation or death). […] The most common presenting symptoms were fever (70%), cough (59%), and dyspnea (43%). 2020-05-19
Earliest cases of coronavirus disease 2019 (COVID-19) identified in solid organ transplant recipients in the United States. With the rapidly expanding pandemic of SARS-CoV-2, there is concern that solid organ transplant recipients will be particularly vulnerable to infection and may experience a more severe clinical course. […] We describe each patient’s medical history including transplantation history, their clinical presentation and workup, and their course from diagnosis to either hospital discharge or to improvement in symptoms. […] These reports demonstrate a range of symptoms, clinical severity, and disease course in solid organ transplant recipients with COVID-19, including two hospitalized patients and two patients managed entirely in the outpatient setting. 2020-05-08
Effect of changing case definitions for COVID-19 on the epidemic curve and transmission parameters in mainland China: a modelling study. When a new infectious disease emerges, appropriate case definitions are important for clinical diagnosis and for public health surveillance. 2020-05-13
COVID-19 coronavirus research has overall low methodological quality thus far: case in point for chloroquine/hydroxychloroquine. We also searched the largest clinical medicine preprint repository, […] The adequately powered, comparative, and robust clinical research that is needed for optimal evidence-informed decision-making remains absent in COVID-19. 2020-05-08
Management of Acute Myocardial Infarction During the COVID-19 Pandemic. This document addresses the care of these patients focusing on 1) the varied clinical presentations; 2) appropriate personal protection equipment (PPE) for health care workers; 3) role of the Emergency Department, Emergency Medical System and the Cardiac Catheterization Laboratory; and 4) Regional STEMI systems of care. 2020-05-03
A multinational, multicentre study on the psychological outcomes and associated physical symptoms amongst healthcare workers during COVID-19 outbreak. Since the declaration of the coronavirus 2019 (COVID-19) outbreak as pandemic, there are reports on the increased prevalence of physical symptoms observed in the general population. […] We investigated the association between psychological outcomes and physical symptoms among healthcare workers. […] The prevalence of physical symptoms displayed by healthcare workers and the associations between physical symptoms and psychological outcomes of depression, anxiety, stress, and post-traumatic stress disorder (PTSD) were evaluated. […] The commonest reported symptom was headache (32.3%), with a large number of participants (33.4%) reporting more than four symptoms. […] Participants who had experienced symptoms in the preceding month were more likely to be older, have pre-existing comorbidities and a positive screen for depression, anxiety, stress, and PTSD. […] After adjusting for age, gender and comorbidities, it was found that depression (OR 2.79, 95% CI 1.54-5.07, p = 0.001), anxiety (OR 2.18, 95% CI 1.36-3.48, p = 0.001), stress (OR 3.06, 95% CI 1.27-7.41, p = 0.13), and PTSD (OR 2.20, 95% CI 1.12-4.35, p = 0.023) remained significantly associated with the presence of physical symptoms experienced in the preceding month. […] Linear regression revealed that the presence of physical symptoms was associated with higher mean scores in the IES-R, DASS Anxiety, Stress and Depression subscales. […] Our study demonstrates a significant association between the prevalence of physical symptoms and psychological outcomes among healthcare workers during the COVID-19 outbreak. […] We postulate that this association may be bi-directional, and that timely psychological interventions for healthcare workers with physical symptoms should be considered once an infection has been excluded. 2020-04-27
Helmet CPAP to Treat Acute Hypoxemic Respiratory Failure in Patients with COVID-19: A Management Strategy Proposal. In fact, the main clinical manifestation of COVID-19 patients is represented by an acute hypoxic respiratory failure secondary to bilateral pulmonary infiltrates, that in many cases, results in an acute respiratory distress syndrome and requires an invasive ventilator support. […] It can also limit the room contamination, improve comfort for the patients, and allow for better clinical assistance with long-term tolerability. 2020-05-23
Sex-Specific SARS-CoV-2 Mortality: Among Hormone-Modulated ACE2 Expression, Risk of Venous Thromboembolism and Hypovitaminosis D. In addition to this first aspect, the recent evidence of an increased frequency of venous thromboembolism in patients with COVID-19 (a clinical element associated with a worse prognosis) calls the attention on the safety of treatment with testosterone, in particular in hypogonadal men with greater genetic predisposition. 2020-04-28
Successful recovery of COVID-19 pneumonia in a patient from Colombia after receiving chloroquine and clarithromycin. We report here the clinical features and therapeutic course of the first reported patient with confirmed COVID-19 pneumonia that recovered in Colombia, after the use of chloroquine and clarithromycin. […] Progressively his clinical condition improved and at day 9, patient rRT-PCR for SARS-CoV-2 became negative. […] This and other COVID-19 cases are urgently demanding results from clinical trials that support evidence-based therapeutical approaches to this pandemic and the clinical management of patients, especially those at critical care. 2020-04-28
Anticipating and Mitigating the Impact of the COVID-19 Pandemic on Alzheimer’s Disease and Related Dementias. We discuss and propose mitigation strategies for: the risk of COVID-19 infection and its associated morbidity and mortality for individuals with ADRD; the impact of COVID-19 on the diagnosis and clinical management of ADRD; consequences of societal responses to COVID-19 in different ADRD care settings; the effect of COVID-19 on caregivers and physicians of individuals with ADRD; mental hygiene, trauma, and stigma in the time of COVID-19; and the potential impact of COVID-19 on ADRD research. 2020-04-28
Guidelines of clinical practice for the management of swallowing disorders and recent dysphonia in the context of the COVID-19 pandemic. Procedures that are particularly at high risk of contamination are clinical and flexible endoscopic pharyngo-laryngological evaluation, and probably also video fluoroscopic swallowing exams. 2020-05-22
Clinical Evaluation of Three Sample-To-Answer Platforms for the Detection of SARS-CoV-2. Our objective was to evaluate three sample-to-answer molecular diagnostic platforms (Cepheid Xpert® Xpress SARS-CoV-2 [Xpert Xpress], Abbott ID NOW™ COVID-19 [ID NOW], GenMark ePlex® SARS-CoV-2 Test [ePlex]) to determine analytical sensitivity, clinical performance, and workflow for the detection of SARS-CoV-2 in nasopharyngeal swabs from 108 symptomatic patients. […] In the workflow analysis, the ID NOW produced the most rapid time to result per specimen (∼17 minutes) as compared to the Xpert Xpress (∼46 minutes) and the ePlex (∼1.5 hours), but what the ID NOW gained in rapid results, it lost in analytical and clinical performance. […] Information about the clinical and analytical performance of these assays, as well as workflow, will be critical in making informed and timely decisions on testing platform. 2020-04-25
Care for adult non-ICU Covid-19 patients: early experiences from a Belgian tertiary care centre. This demanded an unprecedented adaptation of our hospital organisation, and we have met many clinical issues in the care for Covid-19 patients. 2020-04-28
18F-FDG PET/CT and Serial Chest CT Findings in a COVID-19 Patient With Dynamic Clinical Characteristics in Different Period. Neurological symptoms and gastrointestinal symptoms were rare at onset in COVID-19. […] Here we report a 37-year-old man with vertigo, fever, and diarrhea symptoms as the first manifestation. […] We illustrate the symptoms initiation, the laboratory test results, the imaging examination, and the treatment strategy in the duration of COVID-19 with a timeline chart. 2020-05-06
Managing Close Contacts of COVID-19 Confirmed Cases in Metropolitan Areas in China. After receiving reports of newly confirmed cases, an epidemiological services team at the CCDC or trained medical professionals at local clinical facilities start a case-contact investigation. 2020-05-29
Lymphopenia that may develop in patients treated with temozolomide and immune control check-point inhibitor may be a high risk for mortality during the COVID-19 outbreak. As we know more about the clinical and laboratory features of COVID-19, which is now accepted as a pandemic, many questions have been raised about how to manage and monitor the treatment of cancer patients. 2020-04-28
Updated diagnosis, treatment and prevention of COVID-19 in children: experts’ consensus statement (condensed version of the second edition). The early warning indicators for severe pediatric cases have been summarized which is utmost important for clinical practice. 2020-05-01
The role of extracorporeal life support for patients with COVID-19: Preliminary results from a statewide experience. There is a paucity of clinical data on critically ill patients with COVID-19 requiring extracorporeal life support. […] A statewide multi-institutional collaborative for COVID-19 patients was utilized to obtain clinical data on the first 10 critically ill COVID-19 patients who required extracorporeal membrane oxygenation (ECMO). […] The most common symptoms leading to the presentation were high fever ≥103°F (90%), cough (80%) and dyspnea (70%), followed by fatigue and gastrointestinal symptoms (both 30%), myalgia, loss of taste, pleuritic chest pain, and confusion (all 10%). […] These preliminary multi-institutional data from a statewide collaborative offer insight into the clinical characteristics of the first 10 patients requiring ECMO for COVID-19 and their initial clinical course. 2020-04-25
Does SARS-Cov-2 invade the brain? Translational lessons from animal models. Clinical heterogeneity potentially driven by differential host immune-mediated responses will require extensive investigation. 2020-05-23
Transmission risk of SARS-CoV-2 to healthcare workers -observational results of a primary care hospital contact tracing. Healthcare worker contacts of an initially undiagnosed COVID-19 case, who were without personal protective equipment, in particular not wearing facemasks, were screened with nasopharyngeal swabs and polymerase chain reaction tests for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), irrespective of respiratory symptoms or fever seven days after initial contact. […] Three healthcare workers reported respiratory symptoms (cough) or low-grade fever within 4 days. […] All 21 healthcare workers tested SARS-CoV-2 negative 7 days after initial index case contact, including the three healthcare workers with previous symptoms. 2020-04-29
Skin cancer triage and management during COVID-19 pandemic. The worldwide medical community is striving to pursue the most appropriate clinical choices in the worst event of pandemic of the modern times [1], with over 1 million patients affected by COVID-19 (i.e., swab positive patients with or without symptoms) reported so far [1]. 2020-04-25
Inhibition of SARS-CoV-2 Infections in Engineered Human Tissues Using Clinical-Grade Soluble Human ACE2. Here, we show that clinical grade hrsACE2 reduced SARS-CoV-2 recovery from Vero cells by a factor of 1,000-5,000. 2020-05-19
Acute Type A Aortic Dissection during COVID-19 Outbreak. In this context, however, there has been little clinical guidance or information regarding life-threatening conditions requiring emergency surgery that cannot be delayed. […] We herein present a case of acute type A aortic dissection with COVID-19 in order to highlight the clinical implications of a true emergent procedure during the COVID-19 outbreak. 2020-04-27
Family-Centered Care During the COVID-19 Era. We provide a toolbox of strategies for supporting family-centered inpatient care during physical distancing responsive to the current clinical climate. 2020-05-13
Current status of potential therapeutic candidates for the COVID-19 crisis. Numerous potential therapies, including supportive intervention, immunomodulatory agents, antiviral therapy, and convalescent plasma transfusion, have been tentatively applied in clinical settings. […] Furthermore, intensive research and clinical trials are underway to assess the efficacy of existing drugs and identify potential therapeutic targets to develop new drugs for treating COVID-19. 2020-04-29
Ayurveda and COVID-19: Where psychoneuroimmunology and the meaning response meet. The COVID-19 pandemic has led to high levels of psychological distress in the general public, including symptoms of anxiety and depression. […] It was found that many of the measures advocated in their guidelines could positively influence immunity either by direct effects on symptoms of depression or anxiety, or through their symbolic significance. 2020-04-28
ACE2 Expression in Pancreas May Cause Pancreatic Damage After SARS-CoV-2 Infection. Combined with clinical data, we showed that pancreatic injury can occur in some COVID-19 patients. 2020-05-23
Clinical value of immune-inflammatory parameters to assess the severity of coronavirus disease 2019. To explore the clinical value of immune-inflammatory markers to assess the severity of coronavirus disease 2019 (COVID-19). 127 consecutive hospitalized patients with confirmed COVID-19 were enrolled in this study, and classified into non-severe and severe groups. […] Demographics, symptoms, underlying diseases and laboratory data were collected and assessed for predictive value. 2020-05-29
Overview of Covid-19; its prevention and management in the light of Unani medicine. The symptoms are fever, malaise, and cough which resolve in a few days in most cases; but may progress to respiratory distress and organ failure. 2020-05-19
Enhancing immunity in viral infections, with special emphasis on COVID-19: A review. While data regarding nutrition in coronavirus infection (COVID-19) are not available, in this review, we aimed to evaluate evidence from previous clinical trials that studied nutrition-based interventions for viral diseases (with special emphasis on respiratory infections), and summarise our observations. […] Clinical trials on vitamins, minerals, nutraceuticals and probiotics were included. 2020-05-27
[COVID-19: Clinical, biological and radiological characteristics in adults, infants and pregnant women. An up-to-date review at the heart of the pandemic]. In order to better address this major health crisis, which has given rise to numerous scientific publications, we have synthesized the main original clinical studies to facilitate the day-to-day management of patients with COVID-19. […] We detail the early signs and progression of the disease as well as the different clinical forms, including extra-pulmonary, as known at the beginning of this pandemic. […] We focus on clinical, biological and CT markers predictive of severity or mortality. 2020-05-08
[Management of a radiotherapy center during the COVID-19 outbreak: The experience of the Mulhouse hospital centre (France)]. Despite most of patients develops benign symptoms, cancer patients are at risk of a severe form of the disease. 2020-04-28
Coronavirus disease 2019 in pregnant women: a report based on 116 cases. To evaluate the clinical characteristics and outcomes in pregnancy and the vertical transmission potential of severe acute respiratory syndrome coronavirus 2 infection. […] Clinical records were retrospectively reviewed for 116 pregnant women with coronavirus disease 2019 pneumonia from 25 hospitals in China between January 20, 2020, and March 24, 2020. […] The most common symptoms were fever (50.9%, 59/116) and cough (28.4%, 33/116); 23.3% (27/116) patients presented without symptoms. 2020-05-26
Management of Lung Nodules and Lung Cancer Screening During the COVID-19 Pandemic: CHEST Expert Panel Report. The panel was convened by video teleconference to discuss and then vote on statements related to 12 common clinical scenarios. […] Twelve statements related to baseline and annual lung cancer screening (n = 2), surveillance of a previously detected lung nodule (n = 5), evaluation of intermediate and high-risk lung nodules (n = 4), and management of clinical stage I non-small cell lung cancer (n = 1) were developed and modified. 2020-05-24
Unexpected BP Sensitivity to Angiotensin II in a Patient With Coronavirus Disease 2019, ARDS, and Septic Shock. Further studies are needed to confirm our observed clinical efficacy. 2020-05-05
Highly sensitive detection of SARS-CoV-2 RNA by multiplex rRT-PCR for molecular diagnosis of COVID-19 by clinical laboratories. The detection of SARS-CoV-2 RNA by real-time reverse transcription-polymerase chain reaction (rRT-PCR) is used to confirm the clinical diagnosis of COVID-19 by molecular diagnostic laboratories. […] The proposed multiplex rRT-PCR methodology will enable highly sensitive detection of SARS-CoV-2 RNA, reducing reagent use and cost, and time required by clinical laboratory technicians. 2020-05-18
The role of community-wide wearing of face mask for control of coronavirus disease 2019 (COVID-19) epidemic due to SARS-CoV-2. Patients presenting with respiratory symptoms at outpatient clinics or hospital wards were screened for COVID-19 per protocol. […] Community-wide mask wearing may contribute to the control of COVID-19 by reducing the amount of emission of infected saliva and respiratory droplets from individuals with subclinical or mild COVID-19. 2020-05-04
Risk factors of critical & mortal COVID-19 cases: A systematic literature review and meta-analysis. We aimed to find risk factors for the progression of COVID-19 to help reducing the risk of critical illness and death for clinical help. […] Clinical manifestations such as fever, shortness of breath or dyspnea were associated with the progression of disease [fever: 0R = 0.56, 95% CI (0.38, 0.82), P = 0.003;shortness of breath or dyspnea: 0R=4.16, 95% CI (3.13, 5.53), P < 0.00001]. […] Laboratory examination such as aspartate amino transferase(AST) > 40U/L, creatinine(Cr) ≥ 133mol/L, hypersensitive cardiac troponin I(hs-cTnI) > 28pg/mL, procalcitonin(PCT) > 0.5ng/mL, lactatede hydrogenase(LDH) > 245U/L, and D-dimer > 0.5mg/L predicted the deterioration of disease while white blood cells(WBC)<4 × 109/L meant a better clinical status[AST > 40U/L:OR=4.00, 95% CI (2.46, 6.52), P < 0.00001; Cr ≥ 133μmol/L: OR = 5.30, 95% CI (2.19, 12.83), P = 0.0002; hs-cTnI > 28 pg/mL: OR = 43.24, 95% CI (9.92, 188.49), P < 0.00001; PCT > 0.5 ng/mL: OR = 43.24, 95% CI (9.92, 188.49), P < 0.00001;LDH > 245U/L: OR = 43.24, 95% CI (9.92, 188.49), P < 0.00001; D-dimer > 0.5mg/L: OR = 43.24, 95% CI (9.92, 188.49), P < 0.00001; WBC < 4 × 109/L: OR = 0.30, 95% CI (0.17, 0.51), P < 0.00001]. […] Clinical manifestation such as fever, shortness of breath or dyspnea and laboratory examination such as WBC, AST, Cr, PCT, LDH, hs-cTnI and D-dimer could imply the progression of COVID-19. 2020-05-03
Clinical and epidemiological features of COVID-19 family clusters in Beijing, China. We present the epidemiological and clinical features of the clusters of three large and one small families. […] Among those infected, 20/22 had mild symptoms and only two had moderate to severe clinical manifestations. […] Children in the families generally showed milder symptoms. 2020-05-03
Is returning to work during the COVID-19 pandemic stressful? A study on immediate mental health status and psychoneuroimmunity prevention measures of Chinese workforce. There were no significant differences in the severity of psychiatric symptoms between workers/technicians and executives/managers. >95% reported psychoneuroimmunity prevention measures including good ventilation in the workplace and wore a face mask as protective. […] Factors that were associated with the severity of psychiatric symptoms in the workforce were marital status, presence of physical symptom, poor physical health and viewing return to work as a health hazard (p < 0.05). […] In contrast, personal psychoneuroimmunity prevention measures including hand hygiene and wearing face masks as well as organizational measures including significant improvement of workplace hygiene and concerns from the company were associated with less severe psychiatric symptoms (p < 0.05). […] Contrary to expectations, returning to work had not caused a high level of psychiatric symptoms in the workforce. […] The low prevalence of psychiatric symptoms could be due to confidence instilled by psychoneuroimmunity prevention measures before the resumption of work. 2020-04-29
Emerging genetic diversity among clinical isolates of SARS-CoV-2: Lessons for today. Considering the current pandemic of COVID-19, it is imperative to gauge the role of molecular divergence in SARS-CoV-2 with time, due to clinical and epidemiological concerns. […] We believe that such molecular analyses correlated with clinical characteristics and host predisposition need to be evaluated at the earliest to understand viral adaptability, disease prognosis, and transmission dynamics. 2020-05-29
SARS-CoV-2: Is it the newest spark in the TORCH? Vaccines targeting women of reproductive age, and in particular pregnant patients, should be evaluated in clinical trials and should include the endpoints of neonatal infection and disease. 2020-05-27
Clinical analysis of ten pregnant women with COVID-19 in Wuhan, China: A retrospective study. This study aims to evaluate the clinical characteristics and outcomes of pregnant women confirmed with COVID-19 to provide reference for clinical work. […] The clinical features and outcomes of 10 pregnant women confirmed with COVID-19 at Maternal and Child Health Hospital of Hubei Province, Tongji Medical College, Huazhong University of Science and Technology, a tertiary- care teaching hospital in Hubei province, Wuhan, China from January 23 to February 23, 2020 were retrospectively analyzed. 2020-05-29
The old but new: Can unfractioned heparin and low molecular weight heparins inhibit proteolytic activation and cellular internalization of SARS-CoV2 by inhibition of host cell proteases? Our hypothesis needs to be tested in in vitro and clinical studies, however as we are in an urgent situation as the burden of SARS-CoV2 is increasing all around the world, we recommend the usage of unfractioned heparin or LMWH in intensive care unit (ICU) and non-ICU hospitalized patients with the risk-benefit judgement of the clinician. 2020-05-26
Improving the efficacy of Chloroquine and Hydroxychloroquine against SARS-CoV-2 may require Zinc additives - A better synergy for future COVID-19 clinical trials. We seek to draw the attention of the scientific community to the possibility of drastically reducing the effects of the virus on the affected patients and improving clinical trials outcome through the synergistic action of zinc and chloroquine in patients suffering from the coronavirus disease. 2020-04-28
Update on treatment of COVID-19: ongoing studies between promising and disappointing results. At the same time, a great number of clinical trials have been launched to investigate the potential efficacy therapies for COVID-19 highlighting the urgent need to get as quickly as possible high-quality evidence. 2020-04-28
The Coronavirus Pandemic: What Does the Evidence Show? CoV, and Middle East Respiratory Syndrome Coronavirus (MERS-CoV) with its clinical presentations. […] There is no proven antiviral agent against SARS-CoV-2 so the treatment for COVID-19 is symptomatic, aiming for the management of the symptoms and prevention of the complications. 2020-04-28
Clinical Profile of Cases of COVID-19 in Far Western Province of Nepal. The novel coronavirus (COVID-19) cause various symptoms such as pneumonia, fever, breathing difficult and lung infection. […] This case series is to describe the initial clinical features of COVID-19 among the patients admitted in isolation ward of Seti Provincial Hospital. […] The patient coming from United Arab Emirate was presented with mild symptoms and others were asymptomatic. 2020-04-29
Management of orthopaedic and traumatology patients during the Coronavirus disease (COVID-19) pandemic in northern Italy. This article aims to share northern Italy’s experience in hospital re-organization and management of clinical pathways for traumatic and orthopaedic patients in the early stages of the COVID-19 pandemic. 2020-05-29
The impact of respiratory protective equipment on difficult airway management: a randomised, crossover, simulation study. The current international COVID-19 health crisis underlines the importance of adequate and suitable personal protective equipment for clinical staff during acute airway management. 2020-05-29
Evaluation of ocular symptoms and tropism of SARS-CoV-2 in patients confirmed with COVID-19. We evaluated ocular symptoms and ocular tropism of SARS-CoV-2 in a group of patients with COVID-19. […] Ocular history and ocular symptoms data were obtained by communicating directly with the subjects. […] Fifteen (27%) had aggravated ocular symptoms, of which 6 (11%) had prodromal ocular symptoms before disease onset. […] Ocular symptoms are relatively common in COVID-19 disease and may appear just before the onset of respiratory symptoms. 2020-04-26
What should a cardiologist know about coronavirus disease 2019? The most common symptoms of COVID‑19 are: fever (81.8%-100%), cough (46.3%-86.2%), myalgia and fatigue (11%-50%), expectoration (4.4%-72%), and dyspnea (18.6%-59%). […] One of the life‑threatening cardiac manifestations is coronavirus fulminant myocarditis, which may also occur without accompanying symptoms of pulmonary involvement. […] Thus, it is important to know typical COVID‑19 symptoms, possible clinical manifestations, complications, and recommended treatment. 2020-04-30
Anesthesia and COVID-19: What We Should Know and What We Should Do. Through a comprehensive review of existing studies on COVID-19, this article presents the epidemiological and clinical characteristics of COVID-19, reviews current medical management, and suggests ways to improve the safety of anesthetic procedures. 2020-05-14
Implications for the use of telehealth in surgical patients during the COVID-19 pandemic. We report the summarized findings of these studies, the financial and HIPAA considerations of using telemedicine, potential benefits, pitfalls and strategies for the utilization of telemedicine into the clinical practice of general surgery and its subspecialties during the COVID-19 pandemic. 2020-05-05
Clinical Consensus Recommendations Regarding Non-Invasive Respiratory Support in the Adult Patient with Acute Respiratory Failure Secondary to SARS-CoV-2 infection. This consensus document has been prepared on evidence-informed guidelines developed by a multidisciplinary panel of health care providers from four Spanish scientific societies (Spanish Society of Intensive Care Medicine [SEMICYUC], Spanish Society of Pulmonologists [SEPAR], Spanish Society of Emergency [SEMES], Spanish Society of Anesthesiology, Reanimation, and Pain [SEDAR]) with experience in the clinical management of patients with COVID-19 and other viral infections, including SARS, as well as sepsis and ARDS. […] The document provides clinical recommendations for the noninvasive respiratory support (noninvasive ventilation, high flow oxygen therapy with nasal cannula) in any patient with suspected or confirmed presentation of COVID-19 with acute respiratory failure. 2020-04-27
New type of corona virus induced acute otitis media in adult. In this paper, we have presented an adult otitis media case whom infected with COVID-19, but she have not any classical COVID-19 symptoms. 2020-04-30
Pharmacotherapy in COVID-19; A narrative review for emergency providers. PubMed and SCOPUS were queried using a combination of the keywords “COVID 19,” “SARS-CoV-2,” and “treatment.” All types of studies were evaluated including systematic reviews, case-studies, and clinical guidelines. […] There are several ongoing clinical trials that are testing the efficacy of single and combination treatments with the drugs mentioned in this review and new agents are under development. 2020-05-03
COVID-19 outbreak: An elusive enemy. Clinical data from hospitals in China have revealed that approximately 10% of the infected patients have severe disease requiring intensive care. 2020-04-30
The pivotal link between ACE2 deficiency and SARS-CoV-2 infection. Clinical reports of patients infected with SARS-CoV-2 show that several features associated with infection and severity of the disease (i.e., older age, hypertension, diabetes, cardiovascular disease) share a variable degree of ACE2 deficiency. 2020-04-30
Treatment of SARS-CoV-2: How far have we reached? Currently, no treatment for SARS-CoV-2 are approved because of lack of evidence, but a number of clinical trials are in process and we are expecting fruitful results very soon. […] This review focuses on various approaches of treatment and few of the most recent clinical trials carried out in this field. 2020-05-08
SARS-CoV-2 (COVID-19) and intravascular volume management strategies in the critically ill. Due to lack of data on treatment strategies specific to this subset of patients, currently available evidence on management of the critically ill needs to be extrapolated and customized to their clinical needs. […] The article calls attention to fluid stewardship in the critically ill with COVID-19 by judiciously applying the evidence-based resuscitation principles to their specific clinical features such as high rates of cardiac injury. 2020-05-06
Brief Review on COVID-19: The 2020 Pandemic Caused by SARS-CoV-2. In this study, we will provide a brief review of viral origin, identification, symptoms, transmission, diagnosis, and potential treatment strategies for the newly identified SARS-CoV-2 strain. 2020-04-30
Focus on Mental Health During the Coronavirus (COVID-19) Pandemic: Applying Learnings from the Past Outbreaks. However, the unpreparedness of the nations, even with the advanced medical sciences and resources, has failed to address the mental health aspect amongst the public, as all efforts are focused on understanding the epidemiology, clinical features, transmission patterns, and management of COVID-19 pneumonia. 2020-04-30
Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2): An Update. The disease is characterized by distinct medical signs and symptoms that include high fever, chills, cough, and shortness of breath or difficulty in breathing. […] The infected people may also present with other symptoms such as diarrhea, myalgia, fatigue, expectoration, and hemoptysis. 2020-04-30
Corona Virus Disease 2019 (COVID-19) Presenting as Acute ST Elevation Myocardial Infarction. Patients with Covid-19 disease commonly present with symptoms related to respiratory illness, and less commonly they develop cardiovascular complications either on presentation or during the course of the disease. 2020-04-30
On the global trends and spread of the COVID-19 outbreak: preliminary assessment of the potential relation between location-specific temperature and UV index. Thus, COVID-19, due to its regular flu-like symptoms, is also expected to show similar seasonality and subside as the global temperatures rise in the northern hemisphere with the onset of spring. 2020-04-30
Atypical presentation of SARS-CoV-2 infection: A case report. The symptoms included fever, coughing, and breathing difficulties. […] A few patients with this infection may only have atypical symptoms, which could lead to a misdiagnosis and subsequently further facilitate the spread of the virus. […] Given the clinical characteristics, epidemiological history, and examination, the patient was diagnosed with coronavirus disease-2019 (COVID-19). […] Our patient had atypical symptoms of COVID-19. 2020-04-30
First reported nosocomial outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in a pediatric dialysis unit. In addition, each contact was assessed for exposure to the index case and monitored for clinical symptoms. […] Eleven cases reported flu-like symptoms without positive results. […] Ct values were significantly lower in cases presenting typical COVID-19 symptoms, suggesting high viral shedding (p =0.007). 2020-05-06
Early risk factors for the duration of SARS-CoV-2 viral positivity in COVID-19 patients. Clinical information and laboratory data were retrieved from electronic medical records. 2020-05-06
Rational Use of Tocilizumab in the Treatment of Novel Coronavirus Pneumonia. Tocilizumab, which is the IL-6 receptor antagonist, has been approved by the US FDA for the treatment of cytokine release syndrome (CRS), is expected to treat cytokine storm caused by COVID-19 and is now in clinical trials. […] In this paper, we will elaborate the role of cytokine storm in COVID-19, the mechanism of tocilizumab on cytokine storm and the key points of pharmaceutical care based on the actual clinical application for COVID-19 in our hospital, the latest research reports, clinical trial progress of tocilizumab, drug instruction from the US FDA, and “Diagnosis and Treatment Plan of Novel Coronavirus Pneumonia (seventh trial edition)” in China, so as to provide reference for the treatment of COVID-19. 2020-05-28
Noscapine, a possible drug candidate for attenuation of cytokine release associated with SARS-CoV-2. Therefore, any treatment which can decrease the severe symptoms due to lung damage may help attenuate mortality rates. 2020-04-27
Severe COVID-19 in a renal transplant recipient: A focus on pharmacokinetics. The clinical course was complicated by extreme overexposure to the mammalian target of rapamycin inhibitor everolimus, following coadministration of chloroquine and lopinavir/ritonavir therapy. 2020-05-13
Two distinct cases with COVID-19 in kidney transplant recipients. Herein, we demonstrated two distinct cases with different clinical progress. […] He was diagnosed with COVID-19 expressing relevant symptoms. […] The second case was developed in a 56-year-old man without any symptoms. […] These apparently different cases suggest that assertive screening and management could improve the clinical course. 2020-05-16
Rheumotologitsts’ view on the use of hydroxychloroquine to treat COVID-19. Anti-malarial medicine chloroquine (CQ) and particularly its chemical analogue hydroxychloroquine (HCQ) have been recommended as promising candidate therapeutics that are now under either compassionate off-label use or clinical trials for the treatment of COVID-19 patients. […] Given the fact that for decades HCQ has been approved as an immunomodulatory drug for the long term treatment of chronic rheumatic diseases, as experienced rheumatologists, we would like to share our thoughts in this regard and trigger a brainstorm among clinical care providers for exchanging their diverse opinions on this urgent topic. 2020-05-05
Focus on Receptors for Coronaviruses with Special Reference to Angiotensin-converting Enzyme 2 as a Potential Drug Target - A Perspective. In this connection, both SARS-CoV and MERS-CoV have been shown to induce T cell apoptosis, thus, aggravating the clinical course of disease [24, 25]. […] Despite lymphopenia, evidence for an exaggerate release of proinflammatory cytokines [interleukin (IL)-1 and IL-6] has been reported in the course acute respiratory syndrome in COVID19 infected patients, thus, aggravating the clinical course of disease [34]. […] Then, Gurwitz suggests to evaluate severity of symptoms in COVID-19 infected patients under previous chronic treatment with AT1R blockers in comparison to COVID-19 infected patients who did not take AT1R blockers [40]. […] Conversely, increase in ACE2 expression may facilitate the access into the host of COVID-19, thus, aggravating the clinical picture. […] Such a dilemma would be solved by clinical trials based on RAS blockade or initiation and monitoring related effects. 2020-04-27
Olfactory and rhinological evaluations in SARS-CoV-2 patients complaining of olfactory loss. The clinical manifestations of Covid-19 range from asymptomatic carrier status to severe pneumonia. […] In a study of 7,736 Covid-19 patients in China, of all the clinical symptoms, hyposmia was not reported in any patient(2). 2020-04-27
COVID-19 in Children: Clinical Approach and Management. Clinical symptoms are similar to any acute respiratory viral infection with less pronounced nasal symptoms. 2020-05-19
Access to evidence-based care for eating disorders during the COVID-19 crisis. The COVID-19 pandemic has forced an abrupt change in the delivery of clinical services, including for individuals with an eating disorder. […] Articles included describe original research or systematic reviews on obstacles to health services use and strategies to improve access to care; technological tools to provide or enhance interventions; patients’ and clinicians’ attitudes or perspectives on using digital tools for clinical care; factors influencing therapeutic alliance; and ideas for improving reach and uptake of digital interventions. 2020-05-15
Experiences and Insights from the Early US COVID-19 Epicenter: A Rapid Assessment Procedure Informed Clinical Ethnography Case Series. A literature review revealed few reports providing front-line clinical and research teams guidance related to multilevel, rapidly evolving COVID-19 directives.Method: The Rapid Assessment Procedure Informed Clinical Ethnography (RAPICE) method was used to develop a clinical case series and conduct participant observation during an ongoing comparative effectiveness trial of peer-integrated, patient-centered interventions after traumatic injury. […] Participants were patients enrolled in the intervention arm of the ongoing trial, as well as front-line clinicians, patient peer interventionists, and clinical research team members implementing the trial. […] A daily clinical research team huddle that flexibly accommodated virtual participation was also feasibly implemented.Conclusions: Primary and secondary COVID-19 prevention strategies can be feasibly integrated into ongoing clinical interventions during the pandemic. […] Routine, proactive clinical and research team communication that transparently addresses ethical tensions and health-sustaining activities may promote well-being for providers grappling with rapidly evolving pandemic directives. 2020-04-27
NA Common symptoms include a fever and persistent cough and COVID-19 patients also often experience an excess of fluid in the lungs, which makes it difficult to breathe. 2020-05-14
COVID-19-Related Web Search Behaviors and Infodemic Attitudes in Italy: Infodemiological Study. The top five searches related to health were “face masks,” “amuchina” (disinfectant), “symptoms of the novel coronavirus,” “health bulletin,” and “vaccines for coronavirus.” The regions of Umbria and Basilicata recorded a high number of infodemic monikers (APC weighted total >140). […] The majority of searches were related to amuchina, face masks, health bulletins, and COVID-19 symptoms. 2020-05-08
Essential Long-Term Care Workers Commonly Hold Second Jobs and Double- or Triple-Duty Caregiving Roles. To slow the spread of COVID-19, both the paid and unpaid activities of these employees warrant consideration in the identification of appropriate clinical, policy, and informal supports. 2020-05-14
Perioperative Considerations During Emergency General Surgery in the Era of COVID-19: A U.S. Experience. The novel coronavirus SARS-CoV-2 (COVID-19) strain has caused a pandemic that affects everyday clinical practice. 2020-05-13
CO-RADS - A categorical CT assessment scheme for patients with suspected COVID-19: definition and evaluation. The system is meant to be used in patients presenting with moderate to severe symptoms of COVID-19. […] The system was evaluated using 105 chest CTs of patients admitted to the hospital with clinical suspicion of COVID-19 in whom RT-PCR was performed (62 +/- 16 years, 61 men, 53 with positive RT-PCR). […] The resulting area under the receiver operating characteristics curve (AUC) was compared to results from RT-PCR and clinical diagnosis of COVID-19. […] The average AUC was 0.91 (95% CI 0.85-0.97) for predicting RT-PCR outcome and 0.95 (95% CI 0.91-0.99) for clinical diagnosis. […] Conclusions CO-RADS is a categorical assessment scheme for pulmonary involvement of COVID-19 on non-enhanced chest CT providing very good performance for predicting COVID-19 in patients with moderate to severe symptoms and has a substantial interobserver agreement, especially for categories 1 and 5. 2020-04-27
Collateral Benefit of COVID-19 Control Measures on Influenza Activity, Taiwan. Meanwhile, nationwide surveillance data revealed drastic decreases in influenza diagnoses in outpatient departments, positivity rates of clinical specimens, and confirmed severe cases during the first 12 weeks of 2020 compared with the same period of 2019. 2020-04-27
A Quantitative Framework for Modeling COVID-19 Risk During Adjuvant Therapy Using Published Randomized Trials of Glioblastoma in the Elderly. Incorporation of COVID-19-associated risk models into analysis of randomized trials can help guide clinical decisions during this pandemic. 2020-05-06
Effect of High vs Low Doses of Chloroquine Diphosphate as Adjunctive Therapy for Patients Hospitalized With Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infection: A Randomized Clinical Trial. This parallel, double-masked, randomized, phase IIb clinical trial with 81 adult patients who were hospitalized with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection was conducted from March 23 to April 5, 2020, at a tertiary care facility in Manaus, Brazilian Amazon. […] Secondary end points included participant clinical status, laboratory examinations, and electrocardiogram results. 2020-04-30
A potential ex vivo infection model of human induced pluripotent stem cell-3D organoids beyond coronavirus disease 2019. Many established medications have been used to treat the disease symptoms; however, no specific drugs or vaccines have been developed. 2020-04-27
Vascular skin symptoms in COVID-19: a french observational study. Usual clinical manifestations of COVID-19 infection include fever, fatigue, myalgia, headache, diarrhea, dry cough, dyspnea that may lead to acute respiratory distress syndrome and death (1). […] Skin symptoms of COVID-19 have been poorly described but may include erythematous rash, urticaria and chicken pox like lesions (2-7). 2020-04-27
Vaginal delivery in SARS-CoV-2-infected pregnant women in Northern Italy: a retrospective analysis. Data were collected from the clinical records using a standardised questionnaire on maternal general characteristics, any medical or obstetric co-morbidity, course of pregnancy, clinical signs and symptoms, treatment of COVID 19 infection, mode of delivery, neonatal data and breastfeeding. 2020-05-29
The role of adipocytes and adipocyte-like cells in the severity of COVID-19 infections. To reduce the severity and mortality with COVID-19, we propose to probe for the clinical response to thiazolidinediones (TZDs), PPARγ agonists, that are the well-known anti-diabetic drugs. 2020-05-27
Measuring weight with e-scales in clinical and research settings during the COVID-19 pandemic. With the COVID-19 pandemic, clinicians and researchers have been suddenly confronted with the difficulty of treatment provision and continuation of clinical trials without face-to-face contact. […] In this piece, we will describe electronic scales (e-scales) and provide guidance on how clinicians/researchers might best implement e-scales in their clinical practice or research studies to remotely measure weight. 2020-04-27
Novel Percutaneous Tracheostomy for Critically Ill Patients with COVID-19. None of health care providers have developed symptoms or tested positive for COVID-19. 2020-05-04
Mental health problems faced by healthcare workers due to the COVID-19 pandemic-A review. Several sociodemographic variables like gender, profession, age, place of work, department of work and psychological variables like poor social support, self-efficacy were associated with increased stress, anxiety, depressive symptoms, insomnia in HCW. 2020-05-30
Clinical characteristics of older patients infected with COVID-19: A descriptive study. This study focused on older patients with COVID-19 infection and analyzed the epidemiological and clinical characteristics of them. […] The information including demographic, epidemiological, clinical, classification of severity and outcomes. […] 56.7 % of elderly confirmed patients were male, fever (78.3 %), cough (56.7 %), dyspnea (30.0 %), and fatigue (23.3 %) were common symptoms of COVID-19 infection. 2020-05-29
Pediatric laryngoscopy and bronchoscopy during the COVID-19 pandemic: A four-center collaborative protocol to improve safety with perioperative management strategies and creation of a surgical tent with disposable drapes. This protocol is a collaborative effort based on knowledge gleaned from clinical and simulation experience from Children’s Hospital Colorado, Children’s Hospital of Philadelphia, The Hospital for Sick Children in Toronto, and Boston Children’s Hospital. 2020-05-19
Turning the Crisis Into an Opportunity: Digital Health Strategies Deployed During the COVID-19 Outbreak. From the adoption of electronic medical records to mobile health apps and other disruptive technologies, digital health solutions have promised a better quality of care at a more sustainable cost. 2020-05-07
Coronavirus Disease 2019 in a Hemodialysis Patient. The patient’s symptoms and lung imaging changes were atypical. 2020-04-27
[Psychosocial Impact of Quarantine Measures During Serious Coronavirus Outbreaks: A Rapid Review]. Across 13 identified studies, quarantine measures were consistently associated with negative psychosocial outcomes, including depressive symptoms, anxiety, anger, stress, posttraumatic stress, social isolation, loneliness and stigmatization. 2020-04-29
[COVID-19 Pandemic: Stress Experience of Healthcare Workers - A Short Current Review]. An extensive strain was reported due to stress experience as well as depression and anxiety symptoms. […] Severe degrees of those symptoms were found in 2.2 % to 14.5 % of all participants. […] The severity of mental symptoms was influenced by age, gender, occupation, specialization, type of activities performed and proximity to COVID-19 patients. […] Considering the frequency of mental symptoms occurring in healthcare workers, accompanying mental health informed interventions to facilitate coping are necessary. 2020-04-29
[The SARS-CoV-2 Pandemic and an Attempted Suicide of a Patient with Delusional Disorder]. The SARS-CoV-2 pandemic triggered increasing symptoms of an undiagnosed delusional disorder at a mid-60-year-old woman resulting in an attempted suicide. […] Because of a pandemic with noticeable and visible social changes, it seems likely that people with previously subclinical psychotic illnesses are more often admitted to psychiatric care for the first time. 2020-04-29
[Pathological changes of the spleen in ten patients with new coronavirus infection by minimally invasive autopsies]. Cough, fever, malaise and dyspnea were the main clinical symptoms. 2020-04-28
[Suggestions on reforming and improving the prevention and treatment system for major epidemic diseases in China]. Based on systematic review of the role of clinical treatment, disease control and scientific research, and combining with the problems exposed by the COVID-19 epidemic, suggestions were proposed to reform and improve the prevention and treatment system for major epidemics diseases in China. […] In clinical treatment, it is necessary to enhance clinical staff’s awareness of law-based reporting, capabilities of syndromic surveillance, the use of infectious diseases reporting systems, and to improve national or local monitoring platforms for emerging infectious diseases detection. 2020-04-28
[Clinical outcomes of COVID-19 cases and influencing factors in Guangdong province]. Objective: To analyze the clinical courses and outcomes of COVID-19 cases and the influencing factors in Guangdong province and provide basis for the formulation or adjustment of medical care and epidemic control strategy for COVID-19. Methods: We collected demographic data, medical histories, clinical courses and outcomes of 1 350 COVID-19 patients reported in Guangdong as of 4 March 2020 via epidemiological investigation and process tracking. […] Disease severity and clinical course characteristics of the patients and influencing factors of severe illness were analyzed in our study. Results: Among 1 350 cases of COVID-19 cases in Guangdong, 72 (5.3%) and 1049 (77.7%) were mild and ordinary cases, 164 (12.1%) were severe cases, 58 (4.3%) were critical cases and 7 (0.5%) were fatal. […] The influencing factors for severe illness or worse included male (aHR=1.87, 95%CI: 1.43-2.46), older age (aHR=1.67, 95%CI: 1.51-1.85), seeking medical care on day 2-3 after onset (aHR=1.73, 95%CI: 1.20-2.50) pre-existing diabetes (aHR=1.75, 95%CI: 1.12-2.73) and hypertension (aHR=1.49, 95%CI: 1.06-2.09). Conclusions: The course of illness and length of hospitalization of COVID-19 cases were generally long and associated with severity of disease clinical outcomes. 2020-04-28
[Preliminary clinical study of direct renin inhibitor aliskiren in the treatment of severe COVID-19 patients with hypertension]. Objective: To explore the feasibility of direct renin inhibitor aliskiren for the treatment of severe patients of COVID-19 with hypertension. Methods: A retrospective case analysis of effectiveness and safety of aliskiren treatment to lower blood pressure in three severe and one critically ill patients of COVID-19 with hypertension. Results: Four patients, two males and two females, with an average age of 78 years (66-87 years), were referred to hospital mainly because of respiratory symptoms. […] The condition improved, and all patients had reached the discharge standard and were discharged. Conclusion: Our preliminary clinical data shows that aliskiren’s antihypertensive therapy is effective and safe for severe COVID-19 patients complicated with hypertension. […] Further clinical aliskiren therapy study is required with more COVID-19 patients.. 目的: 探索直接肾素抑制剂阿利吉伦用于重型新型冠状病毒肺炎(COVID-19)合并高血压患者治疗的可行性。 2020-04-28
[Comparison of epidemiological and clinical characteristics of SARS, pandemic (H1N1) 2009 and COVID-19, and consideration on prevention and control strategies of COVID-19]. We compared the epidemiological and clinical characteristics of severe acute respiratory syndrome (SARS), pandemic (H1N1) 2009 and COVID-19 and found that COVID-19 was more contagious, more concealed in transmission, with greater infectious intensity and more severe clinical manifestations. 2020-04-28
Optimal Nutritional Status for a Well-Functioning Immune System Is an Important Factor to Protect against Viral Infections. A wealth of mechanistic and clinical data show that vitamins, including vitamins A, B6, B12, C, D, E, and folate; trace elements, including zinc, iron, selenium, magnesium, and copper; and the omega-3 fatty acids eicosapentaenoic acid and docosahexaenoic acid play important and complementary roles in supporting the immune system. 2020-04-30
Otolaryngology Education in the Setting of COVID-19: Current and Future Implications. The pandemic has resulted in significant changes in clinical practice for otolaryngologists in the United States; many changes have been implemented to mitigate risks identified by otolaryngologists in other countries. […] As a result of COVID-19 recommendations, multiple institutions have overhauled resident clinical rotations and resident education. 2020-04-28
Best Practice Recommendations for Pediatric Otolaryngology during the COVID-19 Pandemic. Clinical data were derived from peer-reviewed primary literature and published guidelines from national or international medical organizations. 2020-04-28
Society for Cardiovascular Magnetic Resonance (SCMR) guidance for the practice of cardiovascular magnetic resonance during the COVID-19 pandemic. Second, when necessary, CMR on patients with confirmed or suspected active COVID-19 should focus on the specific clinical question with an emphasis on myocardial function and tissue characterization while optimizing patient and staff safety. 2020-04-30
On the Pharmacy Radar: COViD-19 and Older People. Issues include pharmacy practice, clinical therapeutics, and possible new treatments for the virus. 2020-04-30
Can You Catch It? Lessons Learned and Modification of ED Triage Symptom- and Travel-Screening Strategy. In August 2014, our team developed and implemented an algorithm to triage suspected cases of Ebola virus disease in a midwestern United States emergency department and outpatient clinics based on patient travel history and symptoms. 2020-04-30
COVID-19 patients presenting with afebrile acute abdominal pain. With the surge in COVID-19 cases worldwide, the medical community should be aware of atypical clinical presentations to help with correct diagnosis, to take the proper measures to place the patient in isolation and to avoid healthcare professionals being infected by coronavirus (SARS-CoV-2). […] To report that patients who subsequently test positive for COVID-19 may present with acute abdominal pain and no pulmonary symptoms, although they already have typical lung lesions on computed tomography (CT) scan. 2020-04-28
Understanding the Renin-Angiotensin-Aldosterone-SARS-CoV-Axis: A Comprehensive Review. While relevant preclinical, experimental models to date favor a protective effect of RAAS-SCoV-axis inhibition on both lung injury and survival, clinical data related to the role of RAAS modulation in the setting of SARS-CoV-2 remains limited. […] We propose a preponderance of evidence that supports clinical equipoise regarding the efficacy of RAAS-based interventions, and the imminent need for a multisite randomised controlled clinical trial to evaluate the inhibition of the RAAS-SCoV-axis on acute lung injury in COVID-19. 2020-05-01
Clinical phenotypes of SARS-CoV-2: implications for clinicians and researchers. Patients with COVID-19 present a broad spectrum of clinical presentation. […] Identifying these clinical phenotypes and applying a personalised approach would benefit the optimisation of therapies and improve outcomes. 2020-05-27
Evaluation of the QIAstat-Dx Respiratory SARS-CoV-2 Panel, the first rapid multiplex PCR commercial assay for SARS-CoV-2 detection. This assay is the first rapid multiplex PCR (mPCR) assay including SARS-CoV-2 detection, and is fully compatible with a non-PCR trained laboratory or point-of-care (POC) testing.This evaluation was performed using 69 primary clinical samples (66 NPS, 1 BAL and 1 tracheal aspirate and 1 bronchial aspirate) comparing the SARS-CoV-2 detection with the currently WHO recommended RT-PCR (WHO-PCR) workflow. […] Additionally, a comparative limit of detection (LoD) assessment was performed between QIAstat-SARS and the WHO-PCR using a quantified clinical sample. […] The overall percent agreement between QIAstat-Dx SARS and WHO-PCR on 69 clinical samples was 97% with a sensitivity at 100% (40/40) and specificity at 93% (27/29). 2020-04-28
Comparison of Four Molecular In Vitro Diagnostic Assays for the Detection of SARS-CoV-2 in Nasopharyngeal Specimens. The clinical presentation of COVID-19 is fairly non-specific, and symptoms overlap with other seasonal respiratory infections concurrently circulating in the population. […] Furthermore, it is estimated that up to 80% of infected individuals experience mild symptoms or are asymptomatic, confounding efforts to reliably diagnose COVID-19 empirically. […] In the present study, we have evaluated the analytical sensitivity and clinical performance of four SARS-CoV-2 molecular diagnostic assays granted Emergency Use Authorization by the FDA using nasopharyngeal swabs from symptomatic patients: the New York SARS-CoV-2 Real-time Reverse Transcriptase (RT)-PCR Diagnostic Panel (Modified CDC), the Simplexa COVID-19 Direct (Diasorin Molecular), GenMark ePlex SARS-CoV-2 assay (GenMark) and the Hologic Panther Fusion® SARS-CoV-2 assay (Hologic). […] This information is crucial for both laboratories and clinical teams, as decisions on which testing platform to implement are made. 2020-04-28
Telemedicine in the Era of COVID-19: The Virtual Orthopaedic Examination. With the onset of the COVID-19 pandemic, the shifting of clinical care to telemedicine visits has been hastened. 2020-05-16
Interactions of coronaviruses with ACE2, angiotensin II, and RAS inhibitors-lessons from available evidence and insights into COVID-19. Importantly, however, there is no clinical or experimental evidence supporting that ARBs and ACEIs either augment the susceptibility to SARS-CoV-2 or aggravate the severity and outcomes of COVID-19 at present. 2020-04-30
Retrospective analysis of laboratory testing in 54 patients with severe- or critical-type 2019 novel coronavirus pneumonia. Timely analysis of the laboratory characteristics associated with 2019 novel coronavirus pneumonia (COVID-19) can assist with clinical diagnosis and prognosis. […] This study is a collection of clinical data from 54 hospitalized adult patients diagnosed with COVID-19 in the Zhongfa Xincheng district of China at Tongji Hospital of Huazhong University of Science and Technology from January 28, 2020 to February 11, 2020. 2020-05-08
Tackling Corona Virus Disease 2019 (COVID 19) in Workplaces. Symptoms usually include fever, cough, difficulty in breathing, pneumonia, severe acute respiratory syndrome. 2020-04-30
[Nosocomial infection with SARS-Cov-2 within Departments of Digestive Surgery]. The clinical, biological and radiological data of the patients who developed a nosocomial infection with SARS-Cov-2 were collected from the computerized medical record. 2020-04-28
[What do surgeons need to know about the digestive disorders and paraclinical abnormalities induced by COVID-19?] The symptoms associated with COVID-19 are mainly characterized by a triad composed of fever, dry cough and dyspnea. […] However, digestive symptoms have also been reported; at first considered as infrequent, they in fact seem to affect (to some extent) more than half of patients. […] The symptoms are mainly manifested by anorexia, diarrhea, nausea and/or vomiting and abdominal pain. […] Even though prognosis is associated with lung injury, digestive symptoms seem significantly more frequent in patients presenting with severe COVID-19 infection. […] Digestive forms, which may be isolated or which can precede pulmonary symptoms, have indeed been reported, with diarrhea as a leading clinical sign. […] No data exist on the interest of digestive endoscopy in cases of persistent digestive symptoms. […] Fecal-oral transmission of the infection is possible, especially insofar as viral shedding in stools seems frequent and of longer duration than at the ENT level, including in patients with negative throat swab and without digestive symptoms. 2020-04-28
Being a front-line dentist during the Covid-19 pandemic: a literature review. Clinical symptoms of coronavirus infections can range from relatively mild (similar to the common cold) to severe (bronchitis, pneumonia, and renal involvement). 2020-04-30
Recommendations on the clinical management of the COVID-19 infection by the «new coronavirus» SARS-CoV2. Spanish Paediatric Association working group. On 31 December 2019, the Wuhan Municipal Committee of Health and Healthcare (Hubei Province, China) reported that there were 27 cases of pneumonia of unknown origin with symptoms starting on the 8 December. […] The Ministry of Health summoned the Specialties Societies to prepare a clinical protocol for the management of COVID-19. 2020-04-30
Pseudo acute myocardial infarction in a young COVID-19 patient. He was treated conservatively, with complete clinical recovery and resolution of his EKG abnormalities. 2020-04-28
A guide for urogynecologic patient care utilizing telemedicine during the COVID-19 pandemic: review of existing evidence. We further compiled expert consensus regarding management of FPMRS patients in the virtual setting, scenarios when in-person visits are necessary, symptoms that should alert providers, and specific considerations for FPMRS patients with suspected or confirmed COVID-19. 2020-05-01
Returning to orthopaedic business as usual after COVID-19: strategies and options. The aim of this manuscript is to review the available strategies in the international literature to efficiently and safely return to both normal orthopaedic surgical activities and to normal outpatient clinical activities in the aftermath of a large epidemic or pandemic. […] After restrictions will be lifted, clinical and surgical volume will progressively increase. 2020-05-29
FDG-PET/CT findings highly suspicious for COVID-19 in an Italian case series of asymptomatic patients. To illustrate the [18F]FDG-PET/CT findings in patients affected by cancer with clinical diagnosis of Covid-19 METHODS: We retrospectively reviewed the cases of patients who showed pulmonary involvement unrelated to cancer metastases on March 13 and 16 2020. […] At 1-week follow-up, 2/5 patients experienced the onset of mild respiratory symptoms. […] The [18F]FDG-PET/CT can identify probable Covid-19 disease in the absence or before symptoms onset and can guide patient management. 2020-05-28
Viral RNA load as determined by cell culture as a management tool for discharge of SARS-CoV-2 patients from infectious disease wards. In a preliminary clinical study, we observed that the combination of hydroxychloroquine and azithromycin was effective against SARS-CoV-2 by shortening the duration of viral load in Covid-19 patients. 2020-05-18
Clinical characteristics of 145 patients with corona virus disease 2019 (COVID-19) in Taizhou, Zhejiang, China. The aim of this study was to investigate the clinical characteristics of Corona Virus Disease 2019 in Taizhou, China. […] All patients with confirmed Corona Virus Disease 2019 were enrolled, and their clinical data were gathered by reviewing electronic medical records. […] Common symptoms included dry cough (81.4%), fever (75.2%), anorexia (42.8%), fatigue (40.7%), chest tightness (32.4%), diarrhea (26.9%) and dizziness (20%). […] Treatments of COVID-19 is still experimental and more clinical trials are needed. 2020-05-07
Objective evaluation of anosmia and ageusia in COVID-19 patients: Single-center experience on 72 cases. Statistically significant differences in chemosensitive recovery were detected based on age and distance from the onset of clinical manifestations. […] Olfactory and gustatory dysfunctions represent common clinical findings in COVID-19 patients. […] Otolaryngologists and head-neck surgeons must by now keep this diagnostic option in mind when evaluating cases of ageusia and nonspecific anosmia that arose suddenly and are not associated with rhinitis symptoms. 2020-05-29
The Use of Non-invasive Vagus Nerve Stimulation to Treat Respiratory Symptoms Associated With COVID-19: A Theoretical Hypothesis and Early Clinical Experience. Most cases are mild, but a significant minority of patients develop moderate to severe respiratory symptoms, with the most severe cases requiring intensive care and/or ventilator support. […] We hypothesize that non-invasive vagus nerve stimulation (nVNS) might provide clinical benefits in patients with respiratory symptoms similar to those associated with COVID-19. […] In case 2, the patient experienced immediate and consistent relief from symptoms of chest tightness and shortness of breath, as well as an improved ability to clear his lungs. […] Preliminary observations and a strong scientific foundation suggest that nVNS might provide clinical benefits in patients with COVID-19 via multiple mechanisms. 2020-05-13
Potential pathogenesis of ageusia and anosmia in COVID-19 patients. From the first reports, ageusia and anosmia appear to be frequent clinical features in coronavirus disease 19 (COVID-19) patients. 2020-04-28
Interim Guidelines on Antiviral Therapy for COVID-19. COVID-19 patients may be asymptomatic or show various clinical manifestations, including acute symptoms such as fever, fatigue, sore throat; pneumonia presenting as acute respiratory distress syndrome; and multiple organ failure. […] As COVID-19 has such varied clinical manifestations and case fatality rates, no standard antiviral therapy regimen has been established other than supportive therapy. […] In the present guideline, we aim to introduce potentially helpful antiviral and other drug therapies based on in vivo and in vitro research and clinical experiences from many countries. 2020-04-28
Severe Thrombocytopenia in a Patient with COVID-19. Since clinical feature of COVID-19 has not been fully evaluated yet, empirical antibacterial agents are frequently combined for the treatment of COVID-19 in addition to antiviral agents, concerning co-existing bacterial pathogens. 2020-04-28
Case Report: Viral Shedding for 60 Days in a Woman with Novel Coronavirus Disease (COVID-19). We report a 71-year-old woman with documented viral shedding (based on reverse transcription-polymerase chain reaction (RT-PCR) testing) of SARS-CoV-2 for 60 days from the onset of symptoms (55 days from her first positive test and 36 days after complete resolution of symptoms). 2020-04-28
Practice recommendations for lung cancer radiotherapy during the COVID-19 pandemic: An ESTRO-ASTRO consensus statement. This joint ESTRO-ASTRO practice recommendation established pragmatic and balanced consensus recommendations in common clinical scenarios of radiotherapy for lung cancer in order to address the challenges of the COVID-19 pandemic. 2020-05-29
Radiotherapy workflow and protection procedures during the Coronavirus Disease 2019 (COVID-19) outbreak: Experience of the Hubei Cancer Hospital in Wuhan, China. During more than one and a half months of uninterrupted radiation oncology clinical operation through the worst of the Wuhan outbreak, no known COVID-19 infection occurred at our radiotherapy center to our patients or employees. 2020-05-27
A rapid review of evidence and recommendations from the SIOPE radiation oncology working group to help mitigate for reduced paediatric radiotherapy capacity during the COVID-19 pandemic or other crises. The general recommendations to mitigate the potential detriment of an unexpected shortage of radiotherapy facilities include: (1) maintain current standards of care as long as possible (2) refer to another specialist paediatric radiotherapy department with similar level of expertise (3) prioritise use of existing radiotherapy resources to treat patients with tumours where radiotherapy has the most effect on clinical outcome (4) use chemotherapy to defer the start of radiotherapy where timing of radiotherapy is not expected to be detrimental (5) active surveillance for low-grade tumours if appropriate and (6) consider iso-effective hypofractionated radiotherapy regimens only for selected patients with predicted poor prognosis. […] It has wider applications for the optimal utilisation of facilities, to improve clinical outcome in low- and middle-income countries, where limited resources continue to be a challenge. 2020-05-27
Upper respiratory tract sampling in COVID-19. The viral load of SARS-CoV-2 RNA in the upper respiratory tract was significantly higher during the first week and peaked at 4-6 days after onset of symptoms, during which it can be potentially sampled. 2020-04-30
Updates on What ACS Reported: Emerging Evidences of COVID-19 with Nervous System Involvement. While clinicians are focused on correcting respiratory homeostasis, echoing the original SARS, SARS-CoV-2 is also invading other end-organs, which may not exhibit overt clinical features. […] In our previous viewpoint, we implored our colleagues to recognize the covert tactics of SARS-CoV-2 and emphasized that symptoms like anosmia, dysgeusia, ataxia, and altered mental status could be early signs of the neurotropic potential of this virus. 2020-05-11
Conducting clinical trials during the COVID-19 pandemic. The COVID-19 pandemic has greatly impacted dermatology clinical trial operations due to mandated governmental and institutional shut-downs and newly implemented restrictions. 2020-05-14
The COVID-19 Global Pandemic: Implications for People With Schizophrenia and Related Disorders. We discuss the implications of the COVID-19 global pandemic with respect to: (1) increased risk of infection and poor outcomes among people with schizophrenia, (2) anticipated adverse mental health consequences for people with schizophrenia, (3) considerations for mental health service delivery in inpatient and outpatient settings, and (4) potential impact on clinical research in schizophrenia. […] Recommendations emphasize rapid implementation of measures to both decrease the risk of COVID-19 transmission and maintain continuity of clinical care and research to preserve safety of both people with schizophrenia and the public. 2020-05-06
A Health System Response to COVID-19 in Long-Term Care and Post-Acute Care: A Three-Phase Approach. Its initial emergence in a skilled nursing facility (SNF) not only highlighted the vulnerability of its patients and residents, but also the limited clinical support that led to national headlines. 2020-05-30
Hand cleaning with ash for reducing the spread of viral and bacterial infections: a rapid review. On 26 March 2020 we searched CENTRAL, MEDLINE, Embase, WHO Global Index Medicus, and the WHO International Clinical Trials Registry Platform. […] A retrospective case-control study and a cohort study assessed diarrhoea in children under the age of five years and self-reported reproductive tract symptoms in women, respectively. […] Similarly, it was very uncertain whether the rate of women experiencing symptoms of reproductive tract infection differed between women cleaning hands with ash compared with cleaning hands using soap (RR 0.48, 95% CI 0.12 to 1.86; very low-certainty evidence) or when compared with handwashing with water only or not washing hands (RR 0.50, 95% CI 0.13 to 1.96; very low-certainty evidence). 2020-04-29
COVID-19 in Tuberculosis patients: a report of three cases. The clinical features and treatment of pulmonary tuberculosis patients with COVID-19 is unclear and understudied. 2020-04-28
Long-term coexistence of SARS-CoV-2 with antibody response in COVID-19 patients. Here, 26 cases of COVID-19 in Jinan, China, were examined and shown to be mild or with common clinical symptoms, and no case of severe symptoms was found among these patients. 2020-05-05
Salivary gland disease in the era of COVID-19 pandemic. These changes raise a lot of questions regarding patient triage and treatment decisions in clinical situations when it is unclear if the workup and management can be postponed. 2020-05-29
COVID-19, coronavirus, SARS-CoV-2 and the small bowel. The initial gastrointestinal symptoms that appear early during the course of Covid-19 support this hypothesis. […] In this special review, we describe the interaction of SARS-CoV-2 with the cell and enterocyte and its potential clinical implications. 2020-05-25
Medication for COVID-19-an Overview of Approaches Currently Under Study. This article is based on a selective literature search in PubMed and, followed by an assessment of the ongoing clinical trials that were revealed by the search. […] The potential therapeutic efficacy and tolerability of these and other active substances remain to be investigated in clinical trials. […] At present, more than 80 trials on COVID-10 have already been registered with Clinical- […] Clinical trials are now indispensable in order to determine the true clinical benefits and risks of the substances that have been found to be active against SARSCoV- 2 in vitro. 2020-05-01
Sex-specific clinical characteristics and prognosis of coronavirus disease-19 infection in Wuhan, China: A retrospective study of 168 severe patients. Clinical characteristics, laboratory parameters, and outcomes were compared and analyzed between males and females. […] Eleven laboratory parameters showed significant differences between male and female patients, and six of them were higher during the whole clinical course in patients who died than in patients who were discharged. […] We highlighted sex-specific differences in clinical characteristics and prognosis. 2020-05-13
Respiratory Muscle Performance Screening for Infectious Disease Management Following COVID-19: A Highly Pressurized Situation. However, measures of respiratory muscle performance are not routinely performed in clinical practice, including those with symptoms such as dyspnea. 2020-04-30
IgA-Ab response to spike glycoprotein of SARS-CoV-2 in patients with COVID-19: A longitudinal study. Validation studies of serological antibody tests must be properly designed for clinical, epidemiological and Public Health objectives such as confirmation of suspected COVID-19 cases, certification of seroconversion after infection, and epidemiological surveillance. 2020-05-18
Use of Tocilizumab for COVID-19-Induced Cytokine Release Syndrome: A Cautionary Case Report. Both patients progressed to sHLH despite treatment with tocilizumab, and one developed viral myocarditis, challenging the safety and clinical usefulness of tocilizumab in the treatment of COVID-19-induced CRS. […] These cases highlight the need for clinical trials to determine optimal patient selection and timing for the use of tocilizumab during this disease process. 2020-05-06
Mild versus severe COVID-19: Laboratory markers. While the clinical status, in particular peripheral oxygen saturation (SpO2) levels, and concurrent comorbidities of COVID-19 patients largely determine the need for their admittance to ICUs, several laboratory parameters may facilitate the assessment of disease severity. 2020-05-29
Eosinophil responses during COVID-19 infections and coronavirus vaccination. Eosinophil levels vary dramatically in a number of clinical settings, especially following eosinophil-targeted therapy, which is now available to selectively deplete these cells. 2020-05-24
COVID-19 pandemic-a focused review for clinicians. A wealth of data has been generated since its emergence in December 2019, and it is vital for clinicians to keep up with this data from across the world at a time of uncertainty and constantly evolving guidelines and clinical practice. […] Here we provide an update for clinicians on the recent developments in the virology, diagnostics, clinical presentation, viral shedding, and treatment options for COVID-19 based on current literature. […] We considered published peer-reviewed papers and non-peer-reviewed pre-print manuscripts on COVID19 and related aspects with an emphasis on clinical management aspects. […] We describe the virological characteristics of SARS-CoV-2 and the clinical course of COVID-19 with an emphasis on diagnostic challenges, duration of viral shedding, severity markers and current treatment options. 2020-05-22
Umifenovir treatment is not associated with improved outcomes in patients with coronavirus disease 2019: a retrospective study. Baseline clinical and laboratory characteristics were comparable between the two groups. […] The median time from onset of symptoms to SARS-CoV-2 turning negative was 18 days (interquartile range (IQR) 12-21) in the umifenovir group and 16 days (IQR 11-21) in the control group (p 0.42). […] A randomized control clinical trial is needed to assess the efficacy of umifenovir. 2020-05-08
In vitro testing of combined hydroxychloroquine and azithromycin on SARS-CoV-2 shows synergistic effect. In vivo it showed efficacy, especially when combined with azithromycin in a preliminary clinical trial. 2020-05-28
COVID-19: Disease, management, treatment, and social impact. The patients show flu-like symptoms with a dry cough, sore throat, high fever, and breathing problems. […] It was analyzed that a combination of antiviral drugs with hydroxyl-chloroquine and azithromycin (with the consultation of a medical practitioner) may be the best option to treat the patients, depending on the patient’s conditions and symptoms. 2020-05-19
COVID-19 and anosmia in Tehran, Iran. Coronaviruses have been known to cause common cold symptoms. […] COVID-19 infections have been described as causing more severe respiratory infections and the symptoms reported by authors from Wuhan, China have not specifically included anosmia. […] Most had either no symptoms or mild respiratory symptoms. 2020-05-12
Respiratory conditions in coronavirus disease 2019 (COVID-19): Important considerations regarding novel treatment strategies to reduce mortality. A novel virus named 2019 novel coronavirus (2019-nCoV/SARS-CoV-2) causes symptoms that are classified as coronavirus disease (COVID-19). […] It was also revealed that alternative treatments currently being considered for COVID-19 such as chloroquine and hydroxychloroquine by increasing hemoglobin production and increasing hemoglobin availability for oxygen binding and acetazolamine (for the treatment of altitude sickness) by causing hyperventilation with associated increasing levels of oxygen and decreasing levels of carbon dioxide in the blood may significantly ameliorate COVID-19 respiratory symptoms. […] In conclusion, is recommend, given HBOT, pRBC, and ESA therapies are currently available and routinely utilized in the treatment of other conditions, that such therapies be tried among COVID-19 patients with serious respiratory conditions and that future controlled-clinical trials explore the potential usefulness of such treatments among COVID-19 patients with respiratory conditions. 2020-05-18
Innate immunity in COVID-19 patients mediated by NKG2A receptors, and potential treatment using Monalizumab, Cholroquine, and antiviral agents. Monalizumab is an inhibiting antibody against NKG2A which can restore the function of CD8 + T and NK cells in cancers, successfully ceasing tumor progression with no significant side effects in Phase 2 clinical trials. 2020-05-18
Cancer patients and research during COVID-19 pandemic: A systematic review of current evidence. In this review paper we expose the challenges of cancer management in the era of SARS-CoV-2, the epidemiological, clinical, pathological and radiological characteristics of the disease in cancer patients and its outcomes on this population. 2020-05-28
The clinical course and its correlated immune status in COVID-19 pneumonia. To explore the clinical course and its dynamic features of immune status in COVID-19 patients and find predictors correlated with severity and prognosis of COVID-19. […] The electronic medical records of 204 patients with COVID-19 pneumonia confirmed by nucleic acid testing were retrospectively collected and analyzed. 2020-05-27
Prognostic value of interleukin-6, C-reactive protein, and procalcitonin in patients with COVID-19. Data on demographic characteristics, baseline clinical characteristics, and the levels of IL-6, CRP, and PCT on admission were collected. 2020-05-27
Industry 4.0 technologies and their applications in fighting COVID-19 pandemic. The available technologies of Industry 4.0 could also help the detection and diagnosis of COVID-19 and other related problems and symptoms. 2020-05-27
Performing Bronchoscopy in Times of the COVID-19 Pandemic: Practice Statement from an International Expert Panel. These recommendations for physicians who perform bronchoscopy will help to protect those patients (un)-affected by the current COVID-19 pandemic, minimize the risk of transmission, and maintain clinical care for all patients. 2020-05-29
[COVID-19-Response - Strategies of the Task-Force Coronavirus and experiences upon implementation in the management of 115 cases at the University Medical Center Freiburg]. Additionally a retrospective observational cohort study with descriptive analysis of epidemiological and clinical data of COVID patients admitted until March 31st was performed. […] In the upcoming pandemic, adequate COVID management and care could be secured by a collaborative approach with inclusion of administrative departments, clinical disciplines and theoretical institutes of the University Medical Center Freiburg. 2020-05-22
General Guidelines in the Management of an Obstetrical Patient on the Labor and Delivery Unit during the COVID-19 Pandemic. As such, clinical protocols and practice on labor and delivery units must adapt to optimize the safety of patients and health care workers and to better conserve health care resources. 2020-04-28
Finding the dose for hydroxychloroquine prophylaxis for COVID-19; the desperate search for effectiveness. These doses are higher than recommended for malaria chemoprophylaxis, and clinical trials are needed to establish safety and efficacy. 2020-04-28
Neuraxial anaesthesia and peripheral nerve blocks during the COVID-19 pandemic: a literature review and practice recommendations. These recommendations focus on seven specific domains including: planning of resources and staffing; modifying the clinical environment; preparing equipment, supplies and drugs; selecting appropriate personal protective equipment; providing adequate oxygen therapy; assessing for and safely performing regional anaesthesia procedures; and monitoring during the conduct of anaesthesia and post-anaesthetic care. 2020-05-14
3-D Printed Protective Equipment during COVID-19 Pandemic. The practicality and clinical suitability of four face shields printed using a fused deposition modeling printer were examined. […] To assess the clinical suitability, each face shield was worn for one hour by 10 clinicians and rated using a visual analogue scale. […] For clinical suitability, a chosen design should allow sufficient space for goggles and N95 respirators as well as maximum coverage of the facial area. 2020-05-19
Clinical characteristics of patients with 2019 coronavirus disease in a non-Wuhan area of Hubei Province, China: a retrospective study. To date, the clinical characteristics of COVID-19 patients in the non-Wuhan areas of Hubei Province in China have not been described. […] We retrospectively analyzed the clinical characteristics and treatment progress of 91 patients diagnosed with COVID-19 in Jingzhou Central Hospital. 2020-04-30
COVID-19: ICU delirium management during SARS-CoV-2 pandemic. This article discusses how ICU professionals (e.g., physicians, nurses, physiotherapists, pharmacologists) can use our knowledge and resources to limit the burden of delirium on patients by reducing modifiable risk factors despite the imposed heavy workload and difficult clinical challenges posed by the pandemic. 2020-04-30
COVID-19: Key Concepts for the Surgeon. In view of the current pandemic by SARS-CoV-2 it deems essential to understand the key concepts about the infection: its epidemiological origin, presentation, clinical course, diagnosis and treatment (still experimental in many cases). 2020-05-01
Otolaryngology during COVID-19: Preventive care and precautionary measures. Literatures on the epidemiology, clinical characteristics and infection control measures of COVID-19 were reviewed, practical knowledge from first-line otolaryngologists in China, the United States, and Brazil were reviewed and collated. […] It was recommended that otolaryngology professionals should improve screening in suspected patients with relevant nasal and pharyngeal symptoms and signs, suspend non-emergency consultations and examinations in clinics, and rearrange the working procedures in operating rooms. 2020-05-03
Clinical characteristics and outcomes of patients with severe covid-19 with diabetes. This study explores the clinical characteristics of patients with diabetes with severe covid-19, and the association of diabetes with survival duration in patients with severe covid-19. […] In this single-center, retrospective, observational study, the clinical and laboratory characteristics of 193 patients with severe covid-19 were collected. 48 patients with severe covid-19 had diabetes, and 145 patients (ie, the controls) did not have diabetes. 2020-04-30
Renal Involvement and Early Prognosis in Patients with COVID-19 Pneumonia. However, little is known about the clinical characteristics of kidney-related complications, including hematuria, proteinuria, and AKI. […] In this retrospective, single-center study in China, we analyzed data from electronic medical records of 333 hospitalized patients with COVID-19 pneumonia, including information about clinical, laboratory, radiologic, and other characteristics, as well as information about renal outcomes. […] Although proteinuria, hematuria, and AKI often resolved in such patients within 3 weeks after the onset of symptoms, renal complications in COVID-19 were associated with higher mortality. 2020-05-30
Scoping review of prevalence of neurologic comorbidities in patients hospitalized for COVID-19. Pooled descriptive statistics of clinical data and comorbidities were examined. […] Emerging literature suggests a daunting clinical relationship between COVID-19 and neurologic illness. 2020-05-29
Battle Buddies: Rapid Deployment of a Psychological Resilience Intervention for Healthcare Workers during the COVID-19 Pandemic. These conditions are engendering high levels of fear and anxiety in the short-term, and place individuals at risk for persistent stress-exposure syndromes, sub-clinical mental health symptoms, and professional burnout in the long-term. 2020-05-19
The trinity of COVID-19: immunity, inflammation and intervention. Alongside investigations into the virology of SARS-CoV-2, understanding the fundamental physiological and immunological processes underlying the clinical manifestations of COVID-19 is vital for the identification and rational design of effective therapies. 2020-05-07
Survey of Insomnia and Related Social Psychological Factors Among Medical Staff Involved in the 2019 Novel Coronavirus Disease Outbreak. The questionnaire, administered through the WeChat program, obtained demographic data and asked self-design questions related to the COVID-19 outbreak, insomnia/depressive/anxiety symptoms, and stress-related symptoms. […] We used a logistic regression analysis to examine the associations between sociodemographic factors and insomnia symptoms. […] Five-hundred-and-sixty-four (36.1%) participants had insomnia symptoms according to the Insomnia Severity Index (ISI) (total score ≥ 8). […] A multiple binary logistic regression model revealed that insomnia symptoms were associated with an education level of high school or below (OR = 2.69, p = 0.042, 95% CI = 1.0-7.0), being a doctor (OR = 0.44, p = 0.007, 95% CI = 0.2-0.8), currently working in an isolation unit (OR = 1.71, p = 0.038, 95% CI = 1.0-2.8), is worried about being infected (OR = 2.30, p < 0.001, 95% CI = 1.6-3.4), perceived lack of helpfulness in terms of psychological support from news or social media with regard to COVID-19 (OR = 2.10, p = 0.001, 95% CI = 1.3-3.3), and having very strong uncertainty regarding effective disease control (OR = 3.30, p = 0.013, 95% CI = 1.3-8.5). […] Our study found that more than one-third of the medical staff suffered insomnia symptoms during the COVID-19 outbreak. 2020-05-05
Structural elucidation of SARS-CoV-2 vital proteins: Computational methods reveal potential drug candidates against main protease, Nsp12 polymerase and Nsp13 helicase. To date, no licensed antiviral drugs or vaccines are available against COVID-19 although several clinical trials are underway to test possible therapies. 2020-05-01
Expert recommendations on blood purification treatment protocol for patients with severe COVID-19: Recommendation and consensus. Based on previous experience of blood purification for patients with severe acute respiratory syndrome and Middle East respiratory syndrome combined with clinical front-line practice, we developed a blood purification protocol for patients with severe COVID-19. 2020-05-01
Clinical and imaging features of COVID-19. The main clinical symptoms of COVID-19 are fever, fatigue, and a dry cough. […] This paper reviews the published literature, guidelines and consensus, and summarizes the clinical and imaging characteristics of COVID-19, in order to provide a reliable basis for early diagnosis and treatment. 2020-05-11
Quantitative computed tomography of the coronavirus disease 2019 (COVID-19) pneumonia. All clinical data and the chest CT on admission were retrospectively reviewed and analyzed. […] The interval from onset symptoms to first chest CT scan was 8 days. 2020-05-01
Crowdsourcing a crisis response for COVID-19 in oncology. These community-led initiatives will fill key knowledge gaps to tackle crucial clinical questions on the complexities of infection with the causative coronavirus SARS-Cov-2 in the large, heterogeneous group of vulnerable patients with cancer. 2020-05-01
Response of ophthalmologists in Israel to the novel coronavirus (2019-nCoV) outbreak. Data was obtained regarding demographics and clinical and surgical practice during the pandemic. 2020-05-07
Epidemiological and clinical features of asymptomatic patients with SARS-CoV-2 infection. We investigated the epidemiological and clinical features of patients infected by SARS-CoV-2 without any symptoms. […] The demographic characteristics, clinical data, treatment, and outcomes of SARS-CoV-2 infected patients without any symptoms were analyzed. […] Patients without any symptoms but with SARS-CoV-2 exposure should be closely monitored and tested for SARS-CoV-2 both in anal and throat swabs to excluded the infection. 2020-05-13
[Optimization of a fluorescent qPCR detection for RNA of SARS-CoV-2]. Therefore, the optimized assay developed in this study can be used in screening and early clinical diagnosis. […] Our work provides a tool to facilitate rapid clinical diagnosis of COVID-19. 2020-05-01
Strong associations and moderate predictive value of early symptoms for SARS-CoV-2 test positivity among healthcare workers, the Netherlands, March 2020. Healthcare workers (n = 803) with mild symptoms were tested for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) (n = 90 positive) and asked to complete a symptom questionnaire. […] A predictive model based on these symptoms showed moderate discriminative value (sensitivity: 91.2%; specificity: 55.6%). 2020-05-01
Clinical characteristics of coronavirus disease (COVID-19) early findings from a teaching hospital in Pavia, North Italy, 21 to 28 February 2020. We describe clinical characteristics, treatments and outcomes of 44 Caucasian patients with coronavirus disease (COVID-19) at a single hospital in Pavia, Italy, from 21-28 February 2020, at the beginning of the outbreak in Europe. 2020-05-04
Redesigning a Department of Surgery during the COVID-19 Pandemic. The department of surgery played a leading role in establishing clinical protocols, guidelines, and policies in preparation for a surge of COVID-19 patients. […] A multidisciplinary approach with input from clinical and nonclinical stakeholders is critical to successful crisis planning. 2020-05-05
Which dermatology patients attend to Dermatology Outpatient Clinics during the SARS-CoV-2 outbreak in Turkey and what happened to them? Their age, sex, diagnosis of disease, requirement for emergent intervention, and their medical records about COVID-19 were obtained. 2020-05-22
Can melatonin reduce the severity of COVID-19 pandemic? Thus, by using the safe over-the-counter drug melatonin, we may be immediately able to prevent the development of severe disease symptoms in coronavirus patients, reduce the severity of their symptoms, and/or reduce the immuno-pathology of coronavirus infection on patients’ health after the active phase of the infection is over. 2020-04-29
National Response to COVID-19 in the Republic of Korea and Lessons Learned for Other Countries. Identified strategies included early recognition of the threat and rapid activation of national response protocols led by national leadership; rapid establishment of diagnostic capacity; scale-up of measures for preventing community transmission; and redesigning the triage and treatment systems, mobilizing the necessary resources for clinical care. […] Key recommendations include (1) recognize the problem, (2) establish diagnostic capacity, (3) implement aggressive measures to prevent community transmission, (4) redesign and reallocate clinical resources for the new environment, and (5) work to limit economic impact through and while prioritizing controlling the spread and impact of COVID-19. 2020-05-04
HIV/SARS-CoV-2 co-infected patients in Istanbul, Turkey. The European AIDS Clinical Society states the lack of evidence for a higher COVID-19 infection rate among people living with HIV (PLHIV) and there is a few published literature on the course of COVID-19 co-infection in PLHIV. 2020-04-29
Self-removing passive drain to facilitate postoperative care via telehealth during the COVID-19 pandemic. When thoughtfully applied in the appropriate clinical context, small practice adaptations like this can facilitate telehealth solutions that diminish unnecessary exposure for patients, their caregivers, and health care staff. 2020-05-29
[SARS-CoV-2 infection and solid organ transplantation]. This review summarizes current knowledge on the incidence and clinical course of SARS-CoV-2 infection in patients with solid organ transplantation. 2020-05-01
[COVID-19 infection in the elderly in French-speaking Switzerland: an inventory of beliefs, convictions and certainties]. Older patients do not always present with typical symptoms (fever, cough and dyspnoea) but sometimes are and remain asymptomatic (contact screening), or have aspecific presentations (altered general condition, falls, delirium, unusual fatigue). 2020-05-01
[COVID-19 from the nephrologist’s point of view]. In this article, we discuss the known or suspected interactions between the virus and the kidneys, as well as their clinical presentations. 2020-05-01
[Anosmia and COVID-19]. These patients should therefore isolate themselves and remain alert to the occurrence of other symptoms suggestive of the infection and/or be tested. 2020-05-01
[Drugs that aggravate the course of COVID-19 : really ?] Any possible clinical impact of these treatments on COVID-19 infection remains to be clarified; in the meantime, they should be continued. 2020-05-01
[Psychiatry in the time of pandemic : forging new ways without getting lost]. At an individual level, they have to adapt their clinical practice and consider specific issues of teleconsultations to address patient’s needs. 2020-05-04
[COVID-19 : Intensive care management]. However recently acquired data and clinical experience suggest that COVID-19-related ARDS presents some specificities that will be summarized in the present article. 2020-05-01
[Organizational Impacts and Clinical Challenges of the COVID-19 Pandemic on a Swiss Tertiary Internal Medicine Department]. Alongside organizational challenges, clinical issues such as rapid respiratory distress, clinical suspicions with negative PCR and treatment uncertainties in the absence of sufficient evidence were overcome. 2020-05-01
Is the Collapse of the Respiratory Center in the Brain Responsible for Respiratory Breakdown in COVID-19 Patients? Therefore, it is important to screen the COVID-19 patients for neurological symptoms as well as possibility of the collapse of the respiratory center in the brainstem should be investigated in depth. 2020-05-22
Effects Of ARBs And ACEIs On Virus Infection, Inflammatory Status And Clinical Outcomes In COVID-19 Patients With Hypertension: A Single Center Retrospective Study. Epidemiological, demographic, clinical and laboratory data were collected, analyzed and compared between these groups. 2020-04-29
Correlation between Heart fatty acid binding protein and severe COVID-19: A case-control study. Our study has been registered with the Chinese Clinical Trial Registry, the registration number: ChiCTR2000029829. 2020-05-04
Classification of the cutaneous manifestations of COVID-19: a rapid prospective nationwide consensus study in Spain with 375 cases. To describe the cutaneous manifestations of COVID-19 disease and to relate them to other clinical findings METHODS: Nationwide case collection survey of images and clinical data. […] Using a consensus, we described 5 clinical patterns. […] We later described the association of these patterns with patient demographics, timing in relation to symptoms of the disease, severity, and prognosis. […] Vesicular eruptions appear early in the course of the disease (15% before other symptoms). […] The pseudo-chilblain pattern frequently appears late in the evolution of the COVID-19 disease (59% after other symptoms), while the rest tend to appear with other symptoms of COVID-19. […] Results are similar for confirmed and suspected cases, both in terms of clinical and epidemiological findings. 2020-04-29
Development of clinical care guidelines for faculty and residents in the era of COVID-19. We describe a small-team “cohorting” protocol including guidelines for faculty and resident in common clinical scenarios with attention paid to the risk of common otolaryngologic procedures. […] A rotating small-team approach was implemented at each clinical site, limiting interaction between department members but providing comprehensive coverage. […] Faculty were involved at the earliest phase of clinical interactions. 2020-05-06
Clinical trials during COVID-19. Some are continuing routinely, especially those who are overseeing clinical trials that could offer life-saving therapies, particularly against the novel coronavirus. 2020-05-02
COVID-19 diagnosis and management: a comprehensive review. The disease caused by SARS-CoV-2, coronavirus disease 2019 (COVID-19), presents flu-like symptoms which can become serious in high-risk individuals. […] Here, we provide an overview of the known clinical features and treatment options for COVID-19. […] We included publications from 1 January 2019 to 3 April 2020 which focused on clinical features and treatments. […] The main symptoms of COVID-19 are fever, cough, fatigue, slight dyspnoea, sore throat, headache, conjunctivitis and gastrointestinal issues. […] Specifically designed randomized clinical trials are needed to determine the most appropriate evidence-based treatment modality. 2020-05-13
Management of dysphagia in the patient with head and neck cancer during COVID-19 pandemic: Practical strategy. This document provides clinical practice guidelines based on available evidence to date to balance the risks of SARS-CoV-2 exposure with the risks associated with dysphagia. […] Despite significant limitations in clinical service provision during the pandemic of COVID-19, a safe and reasonable dysphagia care pathway can still be implemented with modifications of setup and application of newer technologies. 2020-05-11
Hyperinflammation and derangement of renin-angiotensin-aldosterone system in COVID-19: A novel hypothesis for clinically suspected hypercoagulopathy and microvascular immunothrombosis. Early clinical evidence suggests that severe cases of coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), are frequently characterized by hyperinflammation, imbalance of renin-angiotensin-aldosterone system, and a particular form of vasculopathy, thrombotic microangiopathy, and intravascular coagulopathy. […] We discuss the underlying pathogenesis and the interaction between multiple systems, resulting in propagation of immunothrombosis, which through investigation in the coming weeks, may lead to both an improved understanding of COVID-19 pathophysiology and identification of innovative and efficient therapeutic targets to reverse the otherwise unfavorable clinical outcome of many of these patients. 2020-05-18
Medical Students Are Not Essential Workers: Examining Institutional Responsibility During the COVID-19 Pandemic. Without the protections provided to paid health care workers, students are uniquely disadvantaged within the medical hierarchy; these inequalities must be addressed before medical students are safely reintegrated into clinical roles. […] Although graduating medical students and institutional leadership may worry that suspending clinical rotations might prevent students from completing graduation requirements, the authors argue the ethical obligation to “flatten the curve” supersedes usual teaching responsibilities. 2020-05-08
Novel biosensor platforms for the detection of coronavirus infection and SARS-CoV-2. These platforms can facilitate routine diagnostic assays in certified clinical labs. 2020-04-29
Genomic Analysis and Comparative Multiple Sequence of SARS-CoV2. Studies about the biological symptoms of SARS-CoV-2 in clinic animal and humans will manipulate an understanding the origin of pandemic crisis. 2020-04-29
COVID-19 Pandemic and Cardiac Electrophysiology: Guidance Protocol From a UK Tertiary Cardiac Centre. The pressure to the health services worldwide has been unprecedented.The redeployment of staff and resources to treat more efficiently COVID-19 cases along with the need to reduce disease transmission has affected the field of electrophysiology among many others.Amendments to clinical pathways are obligatory in this perspective to continue to provide the necessary health services to the people who need them while at the same time infection control and prevention are not compromised by inadvertent disease transmission or unnecessary use of resources.We aim to providea guide of the logistic aspects of electrophysiology procedures derived fromour Tertiary Cardiac Centre duringthe current COVID-19 pandemic. 2020-05-01
Protection by Exclusion: Another Missed Opportunity to Include Pregnant Women in Research During the Coronavirus Disease 2019 (COVID-19) Pandemic. However, once again, pregnant and breastfeeding women are excluded from participating in clinical trials during this pandemic. […] This “protection by exclusion” of pregnant women from drug development and clinical therapeutic trials, even during epidemics and pandemics, is not unprecedented. […] Therefore, we recommend and urge the scientific community and professional societies that, without clear justification for exclusion, pregnant women should be given the opportunity to be included in clinical trials for COVID-19 based on the concepts of justice, equity, autonomy, and informed consent. 2020-05-26
Is COVID Evolution Due to Occurrence of Pulmonary Vascular Thrombosis? In this hypothesis paper, we suggest that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) may induce intravascular pulmonary thrombosis, which may result in the rapid worsening of clinical conditions and, eventually, exitus. 2020-05-30
Hypercoagulation and Antithrombotic Treatment in Coronavirus 2019: A New Challenge. Thus, we performed a systematic review of COVID-19 literature reporting measures of clotting activation to assess if changes are detectable in this setting and their relationship with clinical severity. 2020-04-29
American College of Rheumatology Guidance for the Management of Adult Patients with Rheumatic Disease During the COVID-19 Pandemic. Clinical questions were collated, and an evidence report was rapidly generated and disseminated. 2020-04-29
Becoming a Faithful Defender: Traditional Chinese Medicine against Coronavirus Disease 2019 (COVID-19). The outbreak caused by COVID-19 is causing a major challenge to clinical management and a worldwide threat to public health. […] Therefore, on the basis of epidemiology and virology information, we reviewed relevant meta-analysis and clinical studies of anti-coronavirus therapeutics by TCM, in the aspect of mortality, symptom improvement, duration and dosage of corticosteroid, incidence of complications and the like. […] In addition, we also summarized preclinical rationale for anti-coronavirus activity by TCM in terms of virion assembly and release, as well as viral entry and replication, which could be a useful contribution for figuring out effective Chinese herbal medicine (CHM) for coronavirus, including ingredients from single monomeric compounds, Chinese herbs, Chinese herb extracts and Chinese herb formulas, or potential targets for medicine. […] We would like to see these relevant studies, ranging from basic researches to clinical application, could provide some idea on effects of CHM to combat COVID-19 or other coronaviruses, and also offer new thinking for the exploration of therapeutic strategies under the guidance of TCM. 2020-04-30
Novel Coronavirus disease (COVID-19) in newborns and infants: what we know so far. The SARS-CoV-2 causes a clinical syndrome designated coronavirus disease 2019 (COVID19) with a spectrum of manifestations ranging from mild upper respiratory tract infection to severe pneumonitis, acute respiratory distress syndrome (ARDS) and death. […] Few cases have been observed in children and adolescents who seem to have a more favorable clinical course than other age groups, and even fewer in newborn babies. […] This review provides an overview of the knowledge on SARS-CoV-2 epidemiology, transmission, the associated clinical presentation and outcomes in newborns and infants up to 6 months of life. 2020-05-01
Systemic sclerosis and the COVID-19 pandemic: World Scleroderma Foundation preliminary advice for patient management. Therefore, with World Scleroderma Foundation endorsement, experts from different specialties including rheumatology, virology and clinical immunology gathered virtually to answer to the main practical clinical questions regarding SARS-CoV-2 infection coming from both patients and physicians. 2020-05-22
The Role of Antibody Testing for SARS-CoV-2: Is There One? While Food and Drug Administration (FDA) emergency use authorization (EUA) is required for clinical application of SARS-CoV-2 molecular tests, submission for EUA is currently a voluntary process for manufacturers of serologic assays. 2020-04-30
Comparison of Commercially Available and Laboratory Developed Assays for in vitro Detection of SARS-CoV-2 in Clinical Laboratories. We compared the analytical performance of a laboratory developed test (LDT) developed in our clinical laboratory based on CDC primer sets and four commercially available, FDA emergency use authorized assays for SARS-CoV-2 (Cepheid, DiaSorin, Hologic Panther, and Roche Cobas) on a total of 169 nasopharyngeal swabs. 2020-04-30
Effective treatment of severe COVID-19 patients with tocilizumab. The changes of clinical manifestations, computerized tomography (CT) scan image, and laboratory examinations were retrospectively analyzed. […] Fever returned to normal on the first day, and other symptoms improved remarkably within a few days. […] Preliminary data show that tocilizumab, which improved the clinical outcome immediately in severe and critical COVID-19 patients, is an effective treatment to reduce mortality. 2020-05-22
Analysis of coagulation parameters in patients with COVID-19 in Shanghai, China. We retrospectively analyzed 303 patients diagnosed with COVID-19 and evaluated the clinical data of 240 patients who were discharged. 2020-04-30
An assessment of real-time RT-PCR kits for SARS-CoV-2 detection. For further validation, the assays were compared with the commercially available kits using SARS CoV-2 viral RNA and the clinical specimens obtained from COVID19-suspected individuals. […] The LightMix Modular SARS and Wuhan CoV E-gene (LN S&W-E) assay was highly sensitive for SARS-CoV-2, as was the N2 set, and both assays had perfectly consistent results with the clinical specimens. 2020-04-30
Cardiovascular Risks in Patients with COVID-19: Potential Mechanisms and Areas of Uncertainty. We aim to review available clinical and biomedical literature on cardiovascular risks of COVID-19. 2020-05-04
Anti COVID-19 Drugs: Need for More Clinical Evidence and Global Action. Several existing antiviral drugs, previously developed or used as treatments for severe acute respiratory syndrome (SARS), Middle East respiratory syndrome (MERS), human immunodeficiency virus (HIV), and malaria, are being investigated as COVID-19 treatments and some of them are being used in clinical trials. […] There are currently no complete data available from large randomized clinical trials (RCTs) to provide clinical guidance on the use, dosing, or duration to validate the effective role, safety profile, and adverse effects of all of the trial drugs for prophylaxis or treatment of COVID-19. […] Therefore, for the better safety of patients with COVID-19, further clinical trials and large randomized controlled studies are needed to validate the effective role, safety profile, and adverse effects of all the potential drugs. 2020-05-29
Use of CT and artificial intelligence in suspected or COVID-19 positive patients: statement of the Italian Society of Medical and Interventional Radiology.
  1. SIRM supports the research on the use of artificial intelligence as a predictive and prognostic decision support system, especially in hospitalized patients and those admitted to intensive care, and welcomes single center of multicenter studies for a clinical validation of the test.
It’s not over until it’s over: the chameleonic behavior of COVID-19 over a six-day period. The current global outbreak of COVID-19 represents a major challenge in terms of epidemiology, contagiousness, treatment, as well as clinical and radiological behavior of this disease. […] Radiological imaging plays a key role in the diagnostic process and during the monitoring of the clinical conditions especially of patients with severe symptoms. 2020-05-13
COVID-19: a defining moment for clinical pharmacology? COVID-19 may also be such a defining moment for clinical pharmacology in terms of its role in drug development and therapy. 2020-04-30