Diagnsose Sentence Context

Table 1. Analysis of context sentence of 21682 absracts clustered as diagnosis.

Title Gene Context Sentence ePubDate
Recent advances in the detection of respiratory virus infection in humans. Conventional diagnostic tests, such as the assays for rapid detection of antiviral antibodies or viral antigens, are widely used in many clinical laboratories. […] With the development of modern technologies, new diagnostic strategies, including multiplex nucleic acid amplification and microarray-based assays, are emerging. […] This review summarizes currently available and novel emerging diagnostic methods for the detection of common respiratory viruses, such as influenza virus, human respiratory syncytial virus, coronavirus, human adenovirus, and human rhinovirus. […] It is anticipated that such data will assist researchers and clinicians to develop appropriate diagnostic strategies for timely and effective detection of respiratory virus infections. 2020-03-19
[Jungle yellow fever with positive serology for leptospira in a young peruvian male]. This case of severe YF with non-fatal outcome emphasizes the importance of adequate syndromic diagnosis, and early and aggressive supportive treatment that can save a patient’s life. 2020-01-23
Genomic characterization of the 2019 novel human-pathogenic coronavirus isolated from a patient with atypical pneumonia after visiting Wuhan. These findings provide the basis for starting further studies on the pathogenesis, and optimizing the design of diagnostic, antiviral and vaccination strategies for this emerging infection. 2020-03-16
Detection of 2019 novel coronavirus (2019-nCoV) by real-time RT-PCR. We aimed to develop and deploy robust diagnostic methodology for use in public health laboratory settings without having virus material available. […] Here we present a validated diagnostic workflow for 2019-nCoV, its design relying on close genetic relatedness of 2019-nCoV with SARS coronavirus, making use of synthetic nucleic acid technology. 2020-02-19
First Case of 2019 Novel Coronavirus in the United States. We report the first case of 2019-nCoV infection confirmed in the United States and describe the identification, diagnosis, clinical course, and management of the case, including the patient’s initial mild symptoms at presentation with progression to pneumonia on day 9 of illness. 2020-03-16
Measures for diagnosing and treating infections by a novel coronavirus responsible for a pneumonia outbreak originating in Wuhan, China. Here, we focus on advances in research and development of fast diagnosis methods, as well as potential prophylactics and therapeutics to prevent or treat 2019-nCoV infection. 2020-03-18
The Novel Coronavirus: A Bird’s Eye View. Herein, we present on an overview of the currently available information on the pathogenesis, epidemiology, clinical presentation, diagnosis, and treatment of this virus. 2020-04-13
[Diagnosis and clinical management of 2019 novel coronavirus infection: an operational recommendation of Peking Union Medical College Hospital (V2.0)]. To standardize the diagnosis and treatment of this new infectious disease, operational guidelines for the diagnosis and management of 2019-nCoV infection is accomplished by Peking Union Medical College Hospital. 2020-02-05
[2019-nCoV: new challenges from coronavirus]. After the outbreak of this disease, Chinese scientists invested a lot of energy to carry out research by developing rapid diagnostic reagents, identifying the characters of the pathogen, screening out clinical drugs that may inhibit the virus, and are rapidly developing vaccines. 2020-02-05
[Efficient management of novel coronavirus pneumonia by efficient prevention and control in scientific manner]. Based on current studies, the author summarized the clinical characteristics and evolution of the novel viral pneumonia, and proposed the key points of diagnosis and treatment, the scientific management of both confirmed and suspected cases, and the scientific management of disease prevention and control. 2020-02-05
[Early detection and disease assessment of patients with novel coronavirus pneumonia]. The novel coronavirus has the characteristics of rapid transmission, atypical clinical symptoms, and easy to affect both lungs, leading to missed diagnosis and misdiagnosis, as well as difficult to detection and assessment at early stage. 2020-02-05
Diagnosis and treatment recommendations for pediatric respiratory infection caused by the 2019 novel coronavirus. Following the latest National recommendations for diagnosis and treatment of pneumonia caused by 2019-nCoV (the 4th edition) and current status of clinical practice in Zhejiang Province, recommendations for the diagnosis and treatment of respiratory infection caused by 2019-nCoV for children were drafted by the National Clinical Research Center for Child Health, the National Children’s Regional Medical Center, Children’s Hospital, Zhejiang University School of Medicine to further standardize the protocol for diagnosis and treatment of respiratory infection in children caused by 2019-nCoV. 2020-02-06
[Analysis of clinical features of 29 patients with 2019 novel coronavirus pneumonia]. According to the relevant diagnostic criteria, the patients were divided into three groups: mild (15 cases), severe (9 cases) and critical (5 cases). […] High resolution CT is of great value in the differential diagnosis of this disease. 2020-02-06
A rapid advice guideline for the diagnosis and treatment of 2019 novel coronavirus (2019-nCoV) infected pneumonia (standard version). This guideline includes the guideline methodology, epidemiological characteristics, disease screening and population prevention, diagnosis, treatment and control (including traditional Chinese Medicine), nosocomial infection prevention and control, and disease nursing of the 2019-nCoV. 2020-03-19
[Interpretation of “Guidelines for the Diagnosis and Treatment of Novel Coronavirus (2019-nCoV) Infection by the National Health Commission (Trial Version 5)”]. the National Health Commission of the People’s Republic of China publish the guidelines for the diagnosis and treatment of novel coronavirus (2019-nCoV) infection (trial version 5) . 2020-02-08
[Expert consensus for bronchoscopy during the epidemic of 2019 Novel Coronavirus infection (Trial version)]. It needs to emphasize that bronchoscopy should not be used as a routine means for the diagnosis of 2019-nCoV infection sampling. 2020-02-08
Diagnosis, treatment, and prevention of 2019 novel coronavirus infection in children: experts’ consensus statement. This statement is based on the Novel Coronavirus Infection Pneumonia Diagnosis and Treatment Standards (the fourth edition) (National Health Committee) and other previous diagnosis and treatment strategies for pediatric virus infections. […] The present consensus statement summarizes current strategies on diagnosis, treatment, and prevention of 2019-nCoV infection in children. 2020-02-08
Epidemiologic characteristics of early cases with 2019 novel coronavirus (2019-nCoV) disease in Korea. In about 20 days since the diagnosis of the first case of the 2019 novel coronavirus (2019-nCoV) in Korea on January 20, 2020, 28 cases have been confirmed. 2020-03-18
Laboratory readiness and response for novel coronavirus (2019-nCoV) in expert laboratories in 30 EU/EEA countries, January 2020. Thirty-eight laboratories in 24 EU/EEA countries had diagnostic tests available by 29 January 2020. 2020-03-20
Consistent detection of 2019 novel coronavirus in saliva. Saliva is a promising non-invasive specimen for diagnosis, monitoring, and infection control in patients with 2019-nCoV infection. 2020-04-03
Clinical and biochemical indexes from 2019-nCoV infected patients linked to viral loads and lung injury. Our results suggest a number of potential diagnosis biomarkers and angiotensin receptor blocker (ARB) drugs for potential repurposing treatment of 2019-nCoV infection. 2020-03-19
[Emergency response plan for the neonatal intensive care unit during epidemic of 2019 novel coronavirus]. During the epidemic of 2019-nCoV, the emergency response plan for the NICU should be based on the actual situation, including diagnosis, isolation, and treatment, as well as available equipment and staffing, and take into account the psychosocial needs of the families and neonatal care staff. 2020-02-19
[Recommendation for the diagnosis and treatment of novel coronavirus infection in children in Hubei (Trial version 1)]. In order to further standardize and enhance the clinical management of 2019-nCoV infection in children, reduce the incidence, and decrease the number of severe cases, we have formulated this diagnosis and treatment recommendation according to the recent information at home and abroad. 2020-02-19
[Management plan for prevention and control of novel coronavirus pneumonia among children in Xiangya Hospital of Central South University]. Under the unified arrangement of the Xiangya Hospital of Central South University, the Department of Pediatrics has formulated an action plan with Xiangya unique model to prevent and control NCP among children according to the current epidemic situation and diagnostic and therapeutic program in China. 2020-02-19
Time Course of Lung Changes On Chest CT During Recovery From 2019 Novel Coronavirus (COVID-19) Pneumonia. Purpose To determine the change in chest CT findings associated with COVID-19 pneumonia from initial diagnosis until patient recovery. 2020-02-13
[An update on the epidemiological characteristics of novel coronavirus pneumonia(COVID-19)]. Strategies for prevention and control of NCP include improving epidemic surveillance, quarantining the source of infection, speeding up the diagnosis of suspected cases, optimizing the management of close contacts, tightening prevention and control of cluster outbreaks and hospital infection, preventing possible rebound of the epidemic after people return to work from the Chinese Spring Festival holiday, and strengthening community prevention and control. 2020-02-14
[Retracted: Clinical and epidemiological characteristics of 34 children with 2019 novel coronavirus infection in Shenzhen]. Chest CT scanning is heplful for early diagnosis. 2020-02-26
Molecular and serological investigation of 2019-nCoV infected patients: implication of multiple shedding routes. It was believed that 2019-nCoV was transmitted through respiratory tract and then induced pneumonia, thus molecular diagnosis based on oral swabs was used for confirmation of this disease. 2020-03-16
[Countermeasures and treatment for aortic acute syndrome with novel coronavirus pneumonia]. Rapid diagnosis of concomitant NCP, safe and effective transportation, implementation of the interventional procedure, protection of vascular surgical team and postoperative management and follow-up of such patients have become urgent problems for us. 2020-02-17
Development of Genetic Diagnostic Methods for Novel Coronavirus 2019 (nCoV-2019) in Japan. Diagnostic systems for 2019-nCoV were developed with urgency. 2020-02-19
Breakthrough: Chloroquine phosphate has shown apparent efficacy in treatment of COVID-19 associated pneumonia in clinical studies. The drug is recommended to be included in the next version of the Guidelines for the Prevention, Diagnosis, and Treatment of Pneumonia Caused by COVID-19 issued by the National Health Commission of the People’s Republic of China for treatment of COVID-19 infection in larger populations in the future. 2020-03-18
Clinical characteristics of 140 patients infected with SARS-CoV-2 in Wuhan, China. Detailed clinical investigation of 140 hospitalized COVID-19 cases suggests eosinopenia together with lymphopenia may be a potential indicator for diagnosis. 2020-02-27
[Preliminary Recommendations for Lung Surgery during 2019 Novel Coronavirus Disease (COVID-19) Epidemic Period]. For patients with lung occupying lesions, the whole process of diagnosis and treatment can not be carried out as usual due to the epidemic. […] All thoracic surgeons in China should work together to develop the proper procedures for the diagnosis and treatment in this special situation, and continuously update the recommendations based on epidemic changes and further understanding of COVID-19. 2020-03-16
[Clinical Management of Lung Cancer Patients during the Outbreak of 2019 Novel Coronavirus Disease (COVID-19)]. With the spread of COVID-19, the routine clinical diagnosis and treatment for lung cancer patients has been disturbed. 2020-03-16
[Preliminary study of the relationship between novel coronavirus pneumonia and liver function damage: a multicenter study]. Clinical classification (mild, moderate, severe, and critical) was carried out according to the diagnosis and treatment program of novel coronavirus pneumonia (Trial Fifth Edition) issued by the National Health Commission. 2020-02-20
[Emergency management of prevention and control of novel coronavirus pneumonia in departments of stomatology]. Complying with overall requirements of the government and regulations on public health emergences, as well as the clinical features of diagnosis and treatment of dental illness, this paper refers to previous guidelines and studies on the infection prevention and control in dental diagnosis and treatment in China and foreign countries. 2020-02-21
Coronavirus Disease 2019 (COVID-19): A Perspective from China. Since most COVID-19 infected patients were diagnosed with pneumonia and characteristic CT imaging patterns, radiological examinations have become vital in early diagnosis and assessment of disease course. […] To date, CT findings have been recommended as major evidence for clinical diagnosis of COVID-19 in Hubei, China. 2020-02-21
[Standardized diagnosis and treatment of colorectal cancer during the outbreak of novel coronavirus pneumonia in Renji hospital]. Referring to the “Diagnosis and Treatment Scheme for NCP (Trial Version 4 and 5)” and combining the actual practice situation in our hospital with the “Summary of New Coronavirus Files of Shanghai Renji Hospital”, we summarize how to carry out the clinical practice of colorectal surgery under the situation of the prevention and control of the NCP epidemiology, meanwhile under such situation aiming the procedure of diagnose and treatment for emergency patients with colorectal tumor, we share the experiences of the diagnosis of colorectal tumor, the management of patients with colorectal cancer who are scheduled to be admitted for surgery, the protection of wards, the perioperative management. […] The main points are as follows: (1) Multidisciplinary team (MDT) must be run through the diagnosis and treatment of colorectal cancer. 2020-02-22
[Psychological intervention in oral patients in novel coronavirus pneumonia outbreak period]. The outbreak of the novel coronavirus has affected the normal diagnosis and treatment services in oral medical institutions across the country. 2020-02-22
The SARS, MERS and novel coronavirus (COVID-19) epidemics, the newest and biggest global health threats: what lessons have we learned? Utilizing the Centers for Disease Control and Prevention (CDC, USA) website, and a comprehensive review of PubMed literature, we obtained information regarding clinical signs and symptoms, treatment and diagnosis, transmission methods, protection methods and risk factors for Middle East Respiratory Syndrome (MERS), Severe Acute Respiratory Syndrome (SARS) and COVID-19. 2020-02-22
[Comparison of the clinical characteristics between RNA positive and negative patients clinically diagnosed with 2019 novel coronavirus pneumonia]. Objective: To raise awareness about 2019 novel coronavirus pneumonia (NCP) and reduce missed diagnosis rate and misdiagnosis rate by comparing the clinical characteristics between RNA positive and negative patients clinically diagnosed with NCP. Methods: From January 2020 to February 2020, 54 patients who were newly diagnosed with NCP in Wuhan Fourth Hospital were included in this study. […] Therefore, we should improve the understanding of NCP to prevent missed diagnosis and misdiagnosis; In addition, more rapid and accurate NCP diagnostic approaches should be further developed. 目的: 比较临床诊断新型冠状病毒肺炎(novel coronavirus pneumonia,NCP)核酸检测阳性与阴性患者临床特征的差异,以提高对NCP的认识,降低漏诊及误诊率。 2020-02-23
2019-nCoV (Wuhan virus), a novel Coronavirus: human-to-human transmission, travel-related cases, and vaccine readiness. Diagnostic PCR protocols can be found at https://www.who.int/health-topics/coronavirus/laboratory-diagnostics-for-novel-coronavirus. 2020-03-18
18F-FDG PET/CT findings of COVID-19: a series of four highly suspected cases. A retrospective review of the patients’ medical history, clinical and laboratory data, as well as imaging findings strongly suggested a diagnosis of COVID-19. […] Although 18F-FDG PET/CT cannot be routinely used in an emergency setting and is generally not recommended for infectious diseases, our pilot data shed light on the potential clinical utility of this imaging technique in the differential diagnosis of complex cases. 2020-04-03
Chest CT Findings in Patients With Coronavirus Disease 2019 and Its Relationship With Clinical Features. Computed tomography plays an important role in the diagnosis and evaluation of this emerging global health emergency. 2020-04-14
[Management of corona virus disease-19 (COVID-19): the Zhejiang experience]. However, since COVID-19 was a newly emerging disease, more work was warranted to improve strategies of prevention, diagnosis and treatment for COVID-19. 2020-03-16
[The treatment proposal for the patients with breast diseases in the central epidemic area of 2019 coronavirus disease]. In the central epidemic area of COVID-19, Hubei province, especially Wuhan, the clinical specialists of breast diseases should consider all of the following factors comprehensively: the prevention of COVID-19, the diagnosis and treatment of breast diseases and the accessibility of medical resources. 2020-02-25
[Surgical treatment strategy for digestive system malignancies during the outbreak of novel coronavirus pneumonia]. After the outbreak of this disease, the overwhelming majority of cities have launched the “first level response” and the regular diagnosis and treatment of cancer patients are greatly affected. […] The epidemic of novel coronavirus pneumonia poses new challenges to diagnosis and treatment of the patients with digestive system malignancies. 2020-02-25
Communicating the Risk of Death from Novel Coronavirus Disease (COVID-19). Third, ascertainment bias and risk of death among all those infected would be smaller when estimated using shorter virus detection windows and less sensitive diagnostic laboratory tests. 2020-03-20
Emergence of Novel Coronavirus 2019-nCoV: Need for Rapid Vaccine and Biologics Development. The collaborative efforts of researchers are needed to fill the knowledge gaps about this new virus, to develop the proper diagnostic tools, and effective treatment to combat this infection. 2020-02-26
Systematic Comparison of Two Animal-to-Human Transmitted Human Coronaviruses: SARS-CoV-2 and SARS-CoV. The goal of this work is to systematically review and compare between SARS-CoV and SARS-CoV-2 in the context of their virus incubation, originations, diagnosis and treatment methods, genomic and proteomic sequences, and pathogenic mechanisms. 2020-03-23
[What are the highlights of “Diagnosis and treatment of Disease 2019 novel coronavirus infection suitable for Military support Hubei medical team”]. According to " the Diagnosis and Treatment of New Coronavirus Pneumonia "(6th edition) of the National Health Commission of the People’s Republic of China, a new guideline for the diagnosis and treatment of 2019 novel coronavirus infection suitable for the military (first trial version) was established. […] Some unique opinions and suggestions are put forward in terms of disease name, diagnosis criteria, antiviral treatment, glucocorticoid application, etc. […] This article will make a proper interpretation in order to understand the guideline better and help guide the diagnosis and treatment of diseases. 2020-02-26
An updated estimation of the risk of transmission of the novel coronavirus (2019-nCov). Due to significant variations in the control strategies, which have been changing over time, and thanks to the introduction of detection technologies that have been rapidly improved, enabling to shorten the time from infection/symptoms onset to diagnosis, leading to faster confirmation of the new coronavirus cases, our previous estimations on the transmission risk of the 2019-nCoV need to be revised. 2020-04-01
[Chemotherapy strategy for colorectal cancer under the outbreak of novel coronavirus pneumonia]. Fever patients during chemotherapy need to receive differential diagnosis and screening according to national standards. 2020-02-26
Correlation of Chest CT and RT-PCR Testing in Coronavirus Disease 2019 (COVID-19) in China: A Report of 1014 Cases. Background Chest CT is used for diagnosis of 2019 novel coronavirus disease (COVID-19), as an important complement to the reverse-transcription polymerase chain reaction (RT-PCR) tests. […] Purpose To investigate the diagnostic value and consistency of chest CT as compared with comparison to RT-PCR assay in COVID-19. […] Conclusion Chest CT has a high sensitivity for diagnosis of COVID-19. 2020-02-26
Development and clinical application of a rapid IgM-IgG combined antibody test for SARS-CoV-2 infection diagnosis. Although the virus (severe acute respiratory syndrome coronavirus [SARS-Cov-2]) nucleic acid real-time polymerase chain reaction (PCR) test has become the standard method for diagnosis of SARS-CoV-2 infection, these real-time PCR test kits have many limitations. […] In addition, we evaluated clinical diagnosis results obtained from different types of venous and fingerstick blood samples. 2020-04-13
Radiological findings from 81 patients with COVID-19 pneumonia in Wuhan, China: a descriptive study. Combining assessment of imaging features with clinical and laboratory findings could facilitate early diagnosis of COVID-19 pneumonia. 2020-04-08
Imaging and clinical features of patients with 2019 novel coronavirus SARS-CoV-2. Chest CT examination plays an important role in the initial diagnosis of the novel coronavirus pneumonia. 2020-04-03
[Treatment strategies of Budd-Chiari syndrome during the epidemic period of 2019 coronavirus disease]. In addition to supporting the frontline actively, medical workers in general surgery spare no efforts in making good diagnosis and treatment of specialized diseases by optimizing treatment process, providing medical advice online, mastering indications of delayed operation and emergency operation reasonably, etc. 2020-02-28
[Discussion on diagnosis and treatment of hepatobiliary malignancies during the outbreak of novel coronavirus pneumonia]. During the epidemic period, the routine diagnosis and treatment of tumor patients was affected with varying degrees. […] In this special period, we performed the superiority of the multi-disciplinary team of diagnosis and treatment, achieved accurate diagnosis and treatment of patients with hepatobiliary malignant tumors, provided support for these patients with limited medical resources, and helped them to survive during the epidemic period.On the basis of fully understanding the new coronavirus pneumonia, the treatment strategy should be changed timely during the epidemic, and more appropriate treatment methods should be adopted to minimize the adverse effect of the epidemic on tumor treatment. 2020-02-28
Clinical and computed tomographic imaging features of novel coronavirus pneumonia caused by SARS-CoV-2. CT scanning provides important bases for early diagnosis and treatment of NCP. 2020-04-06
[Recommendations for the regulation of medical practices of burn treatment during the outbreak of the coronavirus disease 2019]. According to the guidelines on the diagnosis and treatment of COVID-19 (6(th) trial edition), the latest relative literature at home and abroad, the features of the COVID-19, recommendations for the COVID-19 prevention and control issued by the National Health Commission of China, and management experience of diagnosis and treatment in the related disciplines, we put forward recommendations for the medical practices of burn treatment during the outbreak of the COVID-19 in outpatient and emergency treatment, inpatient treatment, operation and ward management, etc. 2020-02-29
2019 novel coronavirus disease (COVID-19) in Taiwan: Reports of two cases from Wuhan, China. The reported cases highlight non-specific clinical presentations of 2019 novel coronavirus disease (COVID-19) as well as the importance of rapid laboratory-based diagnosis. 2020-04-01
[Medical diagnosis and treatment strategies for malignant tumors of the digestive system during the outbreak of novel coronavirus pneumonia]. Since the outbreak of novel coronavirus pneumonia in December 2019, the diagnosis and treatment of patients with cancer have been facing great challenges. […] Although oncologists are not fighting on the front line to against the epidemic, during this special period, we should not only protect patients, their families and medical staff from the infection of novel Coronavirus, but also minimize the impact of the epidemic on the diagnosis and the treatment of patients with cancer. […] Combining the guidelines for diagnosis and treatment of tumors with our clinical experience, in this epidemic period, we discuss the strategies for diagnosis, treatment, and follow-up of malignant tumors of the digestive system in this article. 2020-02-29
Characteristics of COVID-19 infection in Beijing. The information on demographic, epidemiological, clinical, laboratory test for the COVID-19 virus, diagnostic classification, cluster case and outcome were obtained. 2020-04-06
Comparison of different samples for 2019 novel coronavirus detection by nucleic acid amplification tests. It might be better to make a diagnosis combining the computed tomography scans and nucleic acid detection. 2020-04-13
Coronavirus disinfection in histopathology. It is feasible that potentially infectious samples may be received in histopathology laboratories for diagnosis. 2020-03-02
[Clinical analysis of 31 cases of 2019 novel coronavirus infection in children from six provinces (autonomous region) of northern China]. Close contact history of epidemiology, nucleic acid detection and chest imaging are important bases for diagnosis. 2020-03-02
[Diagnostic and therapeutic strategies of lung cancer patients during the outbreak of 2019 novel coronavirus disease (COVID-19)]. The diagnosis and treatment of lung cancer patients have been challenged greatly because of extraordinary public health measures since the lung cancer patients are a high-risk population during the COVID-19 outbreak period. 2020-03-02
Fecal specimen diagnosis 2019 novel coronavirus-infected pneumonia. These results may help to understand the clinical diagnosis and the changes in clinical parameters of COVID-19. 2020-03-12
[Management and clinical thinking of Coronavirus Disease 2019]. How to make early diagnosis? 2020-03-03
Differential diagnosis of illness in patients under investigation for the novel coronavirus (SARS-CoV-2), Italy, February 2020. Since the symptoms are similar to other respiratory infections, differential diagnosis in travellers arriving from countries with wide-spread COVID-19 must include other more common infections such as influenza and other respiratory tract diseases. 2020-03-18
Coronavirus Disease 2019 (COVID-19): Role of Chest CT in Diagnosis and Management. OBJECTIVE. The objective of our study was to determine the misdiagnosis rate of radiologists for coronavirus disease 2019 (COVID-19) and evaluate the performance of chest CT in the diagnosis and management of COVID-19. […] The CT features of COVID-19 are reported and compared with the CT features of other viruses to familiarize radiologists with possible CT patterns. MATERIALS AND METHODS. This study included the first 51 patients with a diagnosis of COVID-19 infection confirmed by nucleic acid testing (23 women and 28 men; age range, 26-83 years) and two patients with adenovirus (one woman and one man; ages, 58 and 66 years). […] There are differences as well as similarities in the CT features of COVID-19 compared with those of the severe acute respiratory syndrome. CONCLUSION. We found that chest CT had a low rate of missed diagnosis of COVID-19 (3.9%, 2/51) and may be useful as a standard method for the rapid diagnosis of COVID-19 to optimize the management of patients. 2020-03-04
Escalating infection control response to the rapidly evolving epidemiology of the coronavirus disease 2019 (COVID-19) due to SARS-CoV-2 in Hong Kong. A bundled approach of active and enhanced laboratory surveillance, early airborne infection isolation, rapid molecular diagnostic testing, and contact tracing for healthcare workers (HCWs) with unprotected exposure in the hospitals was implemented. 2020-04-09
Improved molecular diagnosis of COVID-19 by the novel, highly sensitive and specific COVID-19-RdRp/Hel real-time reverse transcription-polymerase chain reaction assay validated in vitro and with clinical specimens. The highly sensitive and specific COVID-19-RdRp/Hel assay may help to improve the laboratory diagnosis of COVID-19. 2020-04-01
[The differential diagnosis of pulmonary infiltrates in cancer patients during the outbreak of the 2019 novel coronavirus disease]. Objective: To investigate the principles of differential diagnosis of pulmonary infiltrates in cancer patients during the outbreak of novel coronavirus (2019-nCoV) by analyzing one case of lymphoma who presented pulmonary ground-glass opacities (GGO) after courses of chemotherapy. Methods: Baseline demographics and clinicopathological data of eligible patients were retrieved from medical records. 2020-03-05
Unique epidemiological and clinical features of the emerging 2019 novel coronavirus pneumonia (COVID-19) implicate special control measures. We summarize latest literatures on genetic, epidemiological, and clinical features of COVID-19 in comparison to SARS and MERS and emphasize special measures on diagnosis and potential interventions. 2020-03-31
The 2019 Novel Coronavirus Outbreak - A Global Threat. Diagnosis is confirmed with PCR based testing of appropriate respiratory samples. […] Standard infection control and prevention techniques should be followed. 2020-03-10
The transmission and diagnosis of 2019 novel coronavirus infection disease (COVID-19): A Chinese perspective. The Chinese government has taken emergency measures to control the outbreak and has undertaken initial steps in the diagnosis and treatment of 2019 novel coronavirus infection disease (COVID-19). […] Our research presents selected available cases of COVID-19 in China to better understand the transmission and diagnosis regarding this infectious disease. 2020-03-12
Middle East respiratory syndrome. This Seminar provides an update on the current knowledge and perspectives on MERS epidemiology, virology, mode of transmission, pathogenesis, diagnosis, clinical features, management, infection control, development of new therapeutics and vaccines, and highlights unanswered questions and priorities for research, improved management, and prevention. 2020-04-13
Diagnosis and Management of First Case of COVID-19 in Canada: Lessons applied from SARS. We report diagnosis and management of the first laboratory-confirmed case of coronavirus disease 2019 (COVID-19) hospitalized in Toronto, Canada. 2020-04-03
[The differential diagnosis for novel coronavirus pneumonia and similar lung diseases in general hospitals]. The National Health Commission, PRC has revised the consensus on diagnosis and treatment seven times in a short period of time, indicating the growing understanding of the disease. […] The diagnosis and differential diagnosis of novel coronavirus pneumonia was facing challenges not only because of large number of tourists increasing dramatically after the relieving of epidemic, but also patients with other diseases return from different areas to search for medical care. […] We were trying to find the similarities and differences among them, and to identify clues to the diagnosis of novel coronavirus pneumonia, so as to ensure accurate diagnosis and treatment. 2020-03-10
Immediate Psychological Responses and Associated Factors during the Initial Stage of the 2019 Coronavirus Disease (COVID-19) Epidemic among the General Population in China. The data will be used for future reference. Methods: From 31 January to 2 February 2020, we conducted an online survey using snowball sampling techniques. 2020-03-18
Rapid establishment of laboratory diagnostics for the novel coronavirus SARS-CoV-2 in Bavaria, Germany, February 2020. The need for timely establishment of diagnostic assays arose when Germany was confronted with the first travel-associated outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in Europe. 2020-03-18
Positive rate of RT-PCR detection of SARS-CoV-2 infection in 4880 cases from one hospital in Wuhan, China, from Jan to Feb 2020. The RT-PCR detection of viral nucleic acid test (NAT) was one of the most quickly established laboratory diagnosis method in a novel viral pandemic, just as in this COVID-19 outbreak. 4880 cases that had respiratory infection symptoms or close contact with COVID-19 patients in hospital in Wuhan, China, were tested for SARS-CoV-2 infection by use of quantitative RT-PCR (qRT-PCR) on samples from the respiratory tract. 2020-04-14
[Construction and evaluation of a novel diagnosis process for 2019-Corona Virus Disease]. Objective: To construct and evaluate a diagnosis process for 2019-Corona Virus Disease (COVID-19). Methods: A continuous cohort of adults and adolescent (≥12 years) who screened COVID-19 was included in Xiangya Hospital of Central South University from January 23 to February 3, 2020 in which cases were divided the test library and the verification library. […] The accuracy of CT to make a definite diagnosis was higher than that of epidemiological history, fever, and blood lymph count decline (0.809 vs 0.660, 0.532, 0.596, P=0.001, 0.002, 0.003, respectively). […] The CT-COVID-19 would have reduced the missed diagnosis rate caused by false negative of nucleic acid test (31 vs 64, difference rate 51.6%), the positive rate of nucleic acid test was 64.5% (20/31). 2020-03-11
CT Manifestations of Novel Coronavirus Pneumonia: A Case Report Then, chest computed tomography was performed and showed bilateral multifocal ground glass opacities with consolidation which suggested viral pneumonia as a differential diagnosis, and the subsequent 2019-novel coronavirus pneumonia nucleic acid test was positive. 2020-04-15
Severe Acute Respiratory Syndrome Coronavirus 2 from Patient with 2019 Novel Coronavirus Disease, United States. A patient in the United States was given a diagnosis of infection with this virus by the state of Washington and the US Centers for Disease Control and Prevention on January 20, 2020. 2020-03-11
Dysregulation of immune response in patients with COVID-19 in Wuhan, China. Surveillance of NLR and lymphocyte subsets is helpful in the early screening of critical illness, diagnosis and treatment of COVID-19. 2020-04-03
A report of clinical diagnosis and treatment of nine cases of coronavirus disease 2019. However, there is no unified standard for the diagnosis and treatment of COVID-19. […] In the retrospective analysis, we report nine cases of COVID-19, describe the history of contact, clinical manifestations, the course of diagnosis and clinical treatment before, during and after treatment. 2020-03-16
[Efficient management of novel coronavirus pneumonia by efficient prevention and control in scientific manner]. Based on current studies, the author summarized the clinical characteristics and evolution of the novel viral pneumonia, and proposed the key points of diagnosis and treatment, the scientific management of both confirmed and suspected cases, and the scientific management of disease prevention and control. 2020-03-13
[Early detection and disease assessment of patients with novel coronavirus pneumonia]. The novel coronavirus has the characteristics of rapid transmission, atypical clinical symptoms, and easy to affect both lungs, leading to missed diagnosis and misdiagnosis, as well as difficult to detection and assessment at early stage. 2020-03-13
[Expert consensus for bronchoscopy during the epidemic of 2019 novel coronavirus infection (Trial version)]. It needs to emphasize that bronchoscopy should not be used as a routine means for the diagnosis of 2019-nCoV infection sampling. 2020-03-13
[Analysis of clinical features of 29 patients with 2019 novel coronavirus pneumonia]. According to the relevant diagnostic criteria, the patients were divided into three groups: mild (15 cases), severe (9 cases) and critical (5 cases). […] High resolution CT is of great value in the differential diagnosis of this disease. 2020-03-13
A Review of Coronavirus Disease-2019 (COVID-19). Diagnosis is by demonstration of the virus in respiratory secretions by special molecular tests. 2020-03-23
[Which sampling method for the upper respiratory tract specimen should be taken to diagnose patient with COVID-19?] According to the guidelines drafted by China’s Center for Disease prevention and Control (CDC), the positive nucleic acid test is need to the diagnosis of patient with COVID-19. […] Therefore, which kind of sampling methods should be chosen to help the COVID-19 diagnosis and which way is the most secure for doctors and nurses is our concern. 2020-03-13
The establishment of reference sequence for SARS-CoV-2 and variation analysis. Establishment of the reference sequence for SARS-CoV-2 could benefit not only biological study of this virus but also diagnosis, clinical monitoring and intervention of SARS-CoV-2 infection in the future. 2020-03-20
Combination of western medicine and Chinese traditional patent medicine in treating a family case of COVID-19 in Wuhan. This report describes the identification, diagnosis, clinical course, and management of three cases from a family, suggests the expected therapeutic effects of SHL on COVID-19, and warrants further clinical trials. 2020-03-14
Coronavirus disease 2019: What we know? The purpose of this review is primarily to review the pathogen, clinical features, diagnosis, and treatment of COVID-19, but also to comment briefly on the epidemiology and pathology based on the current evidence. 2020-03-29
New insights on the antiviral effects of chloroquine against coronavirus: what to expect for COVID-19? The efforts of international health authorities have since focused on rapid diagnosis and isolation of patients as well as the search for therapies able to counter the most severe effects of the disease. 2020-04-04
Arbidol combined with LPV/r versus LPV/r alone against Corona Virus Disease 2019: A retrospective cohort study. The primary endpoint was a negative conversion rate of coronavirus from the date of COVID-19 diagnosis(day7, day14), and assessed whether the pneumonia was progressing or improving by chest CT (day7). […] We analyzed 16 patients who received oral arbidol and LPV/r in the combination group and 17 who oral LPV/r only in the monotherapy group, and both initiated after diagnosis. 2020-04-16
The effectiveness of quarantine and isolation determine the trend of the COVID-19 epidemics in the final phase of the current outbreak in China. The detection and diagnosis have been improved as well. 2020-03-15
The SARS-CoV-2 outbreak: what we know. This paper aggregates and consolidates the epidemiology, clinical manifestations, diagnosis, treatments and preventions of this new type of coronavirus. 2020-04-01
Potential preanalytical and analytical vulnerabilities in the laboratory diagnosis of coronavirus disease 2019 (COVID-19). As the current gold standard for the etiological diagnosis of SARS-CoV-2 infection is (real time) reverse transcription polymerase chain reaction (rRT-PCR) on respiratory tract specimens, the diagnostic accuracy of this technique shall be considered a foremost prerequisite. […] Some analytical problems may also contribute to jeopardize the diagnostic accuracy, including testing outside the diagnostic window, active viral recombination, use of inadequately validated assays, insufficient harmonization, instrument malfunctioning, along with other specific technical issues. […] Some practical indications can hence be identified for minimizing the risk of diagnostic errors, encompassing the improvement of diagnostic accuracy by combining clinical evidence with results of chest computed tomography (CT) and RT-PCR, interpretation of RT-PCR results according to epidemiologic, clinical and radiological factors, recollection and testing of upper (or lower) respiratory specimens in patients with negative RT-PCR test results and high suspicion or probability of infection, dissemination of clear instructions for specimen (especially swab) collection, management and storage, together with refinement of molecular target(s) and thorough compliance with analytical procedures, including quality assurance. 2020-04-01
Diagnosis and clinical management of severe acute respiratory syndrome Coronavirus 2 (SARS-CoV-2) infection: an operational recommendation of Peking Union Medical College Hospital (V2.0). To standardize the diagnosis and treatment of this new infectious disease, an operational recommendation for the diagnosis and management of SARS-CoV-2 infection is developed by Peking Union Medical College Hospital. 2020-03-17
2019 Novel Coronavirus (COVID-19) Pneumonia with Hemoptysis as the Initial Symptom: CT and Clinical Features. Owing to the complications of COVID-19 pneumonia, the first symptom and imaging features of patients can be very atypical and early diagnosis of COVID-19 infections remains a challenge. 2020-03-16
[Management strategies for patients with gynecological malignancies during the outbreak of COVID19]. Objective: To explore the management strategies for patients with gynecological malignant tumors during the outbreak and transmission of COVID19. Methods: We retrospectively analyzed the clinical characteristics, treatment, and disease outcomes of three patients with gynecological malignancies associated with COVID19 in Renmin Hospital of Wuhan University in January 2020, and proposed management strategies for patients with gynecological tumors under risk of COVID19. Results: Three patients were treated COVID19 based on the national diagnosis and treatment protocol as well as research progress. […] While actively preventing and controlling COVID-19, the diagnosis and treatment of gynecological malignant tumors should be carried out in an orderly and safe manner. 目的: 在新型冠状病毒肺炎(COVID-19)暴发和传播期间,探讨妇科恶性肿瘤患者的管理策略。 2020-03-16
Era of molecular diagnosis for pathogen identification of unexplained pneumonia, lessons to be learned. In this study, we illustrated the importance of combining molecular diagnostics to rule out common pathogens and performed mNGS to obtain unbiased potential pathogen result for the diagnosis of UP. 2020-03-17
Epidemiology of COVID-19 Among Children in China. The epidemic curves were constructed by key dates of disease onset and case diagnosis. […] Onset-to-diagnosis curves were constructed by fitting a log-normal distribution to data on both onset and diagnosis dates. 2020-04-09
A 55-Day-Old Female Infant infected with COVID 19: presenting with pneumonia, liver injury, and heart damage. We report a 55-day-old case with COVID-19 confirmed in China and describe the identification, diagnosis, clinical course, and treatment of the patient, including the disease progression from day 7 to day 11 of illness. 2020-03-17
Clinical features of pediatric patients with COVID-19: a report of two family cluster cases. We should attach importance to early recognition, early diagnosis, and early treatment of infected children. 2020-03-17
The positive impact of lockdown in Wuhan on containing the COVID-19 outbreak in China. We evaluated the correlation of domestic air traffic to the number of confirmed COVID-19 cases and determined the growth curves of COVID-19 cases within China before and after lockdown as well as after changes in COVID-19 diagnostic criteria. […] A further increase is detected after changing diagnostic and testing methodology to 19.3 (95% CI: 15.1-26.3), respectively. 2020-03-17
Epidemiologic and Clinical Characteristics of 91 Hospitalized Patients with COVID-19 in Zhejiang, China: A retrospective, multi-centre case series. The median of incubation period was 6 (IQR, 3-8) days and the median time from first visit to a doctor to confirmed diagnosis was 1 (1-2) days. 2020-03-17
Diagnostic utility of clinical laboratory data determinations for patients with the severe COVID-19. The role of clinical laboratory data in the differential diagnosis of the severe forms of COVID-19 has not been definitely established. 2020-04-10
Epidemiology, causes, clinical manifestation and diagnosis, prevention and control of coronavirus disease (COVID-19) during the early outbreak period: a scoping review. In this scoping review, 65 research articles published before 31 January 2020 were analyzed and discussed to better understand the epidemiology, causes, clinical diagnosis, prevention and control of this virus. […] During this early period, published research primarily explored the epidemiology, causes, clinical manifestation and diagnosis, as well as prevention and control of the novel coronavirus. 2020-03-19
[Challenges and countermeasures on Chinese malaria elimination programme during the coronavirus disease 2019 (COVID-19) outbreak]. If the diagnosis and treatment of malaria cases as well as the investigation and response of the epidemic foci are not carried out timely, it may endanger patients’lives and cause the possible of secondary transmission, which threatens the achievements of malaria elimination in China. […] Due to the extensive spread and high transmission ability of the COVID-19, there is a possibility of virus infections among malaria cases during the medical care-seeking behaviors and among healthcare professionals during clinical diagnosis and treatment, sample collection and testing and epidemiological surveys. 2020-03-19
Insight into COVID-2019 for pediatricians. The World Health Organization confirmed this diagnosis and named the pathogen SARSCoV-2. […] From the perspective of clinical pediatricians as the first line fighting the epidemic, this paper will discuss the clinical characteristics, prevention and control measures, outcomes, diagnosis, and treatment of pediatric cases. 2020-04-16
[Countermeasures and treatment for aortic acute syndrome with 2019 coronavirus disease]. Rapid diagnosis of concomitant COVID-19, safe and effective transportation, implementation of the interventional procedure, protection of vascular surgical team and postoperative management and follow-up of such patients have become urgent problems for us. 2020-03-19
[2019-nCoV: new challenges from coronavirus]. After the outbreak of this disease, Chinese scientists invested a lot of energy to carry out research by developing rapid diagnostic reagents, identifying the characters of the pathogen, screening out clinical drugs that may inhibit the virus, and are rapidly developing vaccines. 2020-03-19
[Coronavirus disease 2019 (COVID-19): update for anesthesiologists and intensivists March 2020]. Diagnosis relies on PCR using specimens from the respiratory tract. 2020-04-10
CT image of novel coronavirus pneumonia: a case report. Knowledge of CT characteristics of COVID-19 pneumonia might be helpful to the early diagnosis and treatment of patients, and to control the spread of infection. 2020-03-19
SARS-CoV-2 and COVID-19: The most important research questions. Here we highlight nine most important research questions concerning virus transmission, asymptomatic and presymptomatic virus shedding, diagnosis, treatment, vaccine development, origin of virus and viral pathogenesis. 2020-03-22
Temporal Changes of CT Findings in 90 Patients with COVID-19 Pneumonia: A Longitudinal Study. Background CT may play a central role in the diagnosis and management of COVID-19 pneumonia. 2020-03-19
Artificial Intelligence Distinguishes COVID-19 from Community Acquired Pneumonia on Chest CT. Diagnostic performance was assessed by the area under the receiver operating characteristic curve (AUC), sensitivity and specificity. 2020-03-19
The critical role of laboratory medicine during coronavirus disease 2019 (COVID-19) and other viral outbreaks. Despite there being evidence that laboratory tests are vital throughout many clinical pathways, there are at least three major areas where in vitro diagnostics can also provide essential contributions to diagnostic reasoning and managed care of patients with suspected or confirmed SARS-CoV-2 infection. […] These include etiological diagnosis, patient monitoring, as well as epidemiologic surveillance. 2020-04-01
COVID-19 epidemic in Switzerland: on the importance of testing, contact tracing and isolation. The World Health Organization recommends a combination of measures: rapid diagnosis and immediate isolation of cases, rigorous tracking and precautionary self-isolation of close contacts. 2020-03-25
[Standardized diagnosis and treatment of colorectal cancer during the outbreak of corona virus disease 2019 in Renji hospital]. Although colorectal surgery is not a front-line subject in the fight against the epidemic, but in this special situation, it is a difficult task to provide the highest quality medical services and ensure the orderly clinical work, on the premise of maximizing the protection for patients and their families, health of medical staff, and the safety of wards and hospitals, We summarize how to carry out the clinical practice of colorectal surgery under the situation of the prevention and control of the COVID-19 epidemiology, including the procedures of diagnose and treatment for emergency patients with colorectal tumor, and share the experiences of the diagnosis of colorectal tumor, the management of patients with colorectal cancer who are scheduled to be admitted for surgery, the protection of wards, the perioperative management. […] The main points are as follows: (1) Multidisciplinary team (MDT) must be run through the diagnosis and treatment of colorectal cancer. 2020-03-23
[Chemotherapy strategy for colorectal cancer under the outbreak of corona virus disease 2019]. Fever patients during chemotherapy need to receive differential diagnosis and screening according to national standards. 2020-03-23
CT manifestations of coronavirus disease-2019: A retrospective analysis of 73 cases by disease severity. We analyzed the initial and follow-up CT features of patients with disease severity, according to the Guidelines for the Diagnosis and Treatment of New Coronavirus Pneumonia. 2020-04-10
Chest CT manifestations of new coronavirus disease 2019 (COVID-19): a pictorial review. In diagnosis, chest computed tomography (CT) manifestations can supplement parts of limitations of real-time reverse transcription polymerase chain reaction (RT-PCR) assay. […] Based on a comprehensive literature review and the experience in the frontline, we aim to review the typical and relatively atypical CT manifestations with representative COVID-19 cases at our hospital, and hope to strengthen the recognition of these features with radiologists and help them make a quick and accurate diagnosis.Key Points • Ground glass opacities, consolidation, reticular pattern, and crazy paving pattern are typical CT manifestations of COVID-19. 2020-03-30
COVID-19 Infection: Implications for Perioperative and Critical Care Physicians. Here, the authors review COVID-19 pathogenesis, presentation, diagnosis, and potential therapeutics, with a focus on management of COVID-19-associated respiratory failure. 2020-04-16
PRESCIENT: platform for the rapid evaluation of antibody success using integrated microfluidics enabled technology. Identifying antibodies (Abs) that neutralize infectious agents is the first step for developing therapeutics, vaccines, and diagnostic tools for these infectious agents. 2020-03-20
Laboratory diagnosis of emerging human coronavirus infections - the state of the art. The three unprecedented outbreaks of emerging human coronavirus (HCoV) infections at the beginning of the twenty-first century have highlighted the necessity for readily available, accurate and fast diagnostic testing methods. […] The laboratory diagnostic methods for human coronavirus infections have evolved substantially, with the development of novel assays as well as the availability of updated tests for emerging ones. […] Several integrated, random-access, point-of-care molecular devices are currently under development for fast and accurate diagnosis of SARS-CoV-2 infections. 2020-04-07
Eleven faces of coronavirus disease 2019. Laboratory detection of the viral nucleic acid can yield false-negative results, and serological testing of virus-specific IgG and IgM antibodies should be used as an alternative for diagnosis. 2020-04-06
Autopsy in suspected COVID-19 cases. It includes a description of hazard group 3 organisms, the category to which SARS-CoV-2 has been assigned, a brief description of what is currently known about the pathological and autopsy findings in COVID-19, a summary of the recommendations for conducting autopsies in suspected COVID-19 cases and the techniques for making the diagnosis at autopsy. 2020-04-02
Profiling Early Humoral Response to Diagnose Novel Coronavirus Disease (COVID-19). The diagnostic value of IgM was evaluated in this cohort. […] Humoral response to SARS-CoV-2 can aid to the diagnosis of COVID-19, including subclinical cases. 2020-03-21
[When COVID-19 encounters interstitial lung disease: challenges and management]. Clinicians need to comprehensively analyze the epidemic history, disease onset characteristics, clinical manifestations, image characteristics, serological andpathogenic microorganism test results to confirm diagnosis. […] Because of this, the article will discuss the issues related to the differential diagnosis and management of COVID-19 and ILD, and try to provide reasonable suggestions. 2020-03-21
Review and Prospect of Pathological Features of Corona Virus Disease. But so far, the pathological diagnosis of COVID-19 has been relatively deficient: it is still confined to the pathological findings of punctured organs, and the majority of medical workers have poor awareness of its pathological characteristics. 2020-04-08
A review of the 2019 Novel Coronavirus (COVID-19) based on current evidence. Based on the current published evidence, we systematically summarizes the epidemiology, clinical characteristics, diagnosis, treatment and prevention of knowledge surrounding COVID-19. 2020-04-16
Systematic review of COVID-19 in children shows milder cases and a better prognosis than adults. Diagnostic findings have been similar to adults, with fever and respiratory symptoms being prevalent, but fewer children seem to have developed severe pneumonia. 2020-04-14
Factors Associated With Mental Health Outcomes Among Health Care Workers Exposed to Coronavirus Disease 2019. Frontline health care workers engaged in direct diagnosis, treatment, and care of patients with COVID-19 were associated with a higher risk of symptoms of depression (OR, 1.52; 95% CI, 1.11-2.09; P = .01), anxiety (OR, 1.57; 95% CI, 1.22-2.02; P < .001), insomnia (OR, 2.97; 95% CI, 1.92-4.60; P < .001), and distress (OR, 1.60; 95% CI, 1.25-2.04; P < .001). […] In this survey of heath care workers in hospitals equipped with fever clinics or wards for patients with COVID-19 in Wuhan and other regions in China, participants reported experiencing psychological burden, especially nurses, women, those in Wuhan, and frontline health care workers directly engaged in the diagnosis, treatment, and care for patients with COVID-19. 2020-04-01
Recommendations by the SEPD and AEG, both in general and on the operation of gastrointestinal endoscopy and gastroenterology units, concerning the current SARS-CoV-2 pandemic (March, 18). Gastrointestinal (GI) endoscopy is a high-risk diagnostic-therapeutic procedure in the case of upper GI examinations, and a moderate to low-risk intervention when involving lower GI explorations. 2020-03-23
[Standardized management guideline for pediatric wards of hematology and oncology during the epidemic of coronavirus disease 2019]. With the spread of coronavirus disease 2019 (COVID-19) and growing knowledge of its diagnosis and treatment, it has been clear that children are also susceptible to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). 2020-03-26
[Clinical features and chest CT findings of coronavirus disease 2019 in infants and young children]. Infants and young children with COVID-19 tend to have mild clinical symptoms and imaging findings not as typical as those of adults, and therefore, the diagnosis of COVID-19 should be made based on imaging findings along with epidemiological history and nucleic acid detection. […] Chest CT has guiding significance for the early diagnosis of asymptomatic children. 2020-03-26
[Twin girls infected with SARS-CoV-2]. This article reports the diagnosis and treatment of twin girls who were diagnosed with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in Hunan Province, China. 2020-03-26
Interrupting COVID-19 transmission by implementing enhanced traffic control bundling: Implications for global prevention and control efforts. This ward houses patients exhibiting atypical manifestations or awaiting definitive diagnosis. 2020-04-16
Rapid viral diagnosis and ambulatory management of suspected COVID-19 cases presenting at the infectious diseases referral hospital in Marseille, France, - January 31st to March 1st, 2020: A respiratory virus snapshot. Rapid virological diagnosis is needed to limit the length of isolation for suspected COVID-19 cases. […] We managed the first 280 patients suspected to have COVID-19 through a rapid care circuit and virological diagnosis in our infectious disease reference hospital in Marseille, France. 2020-04-10
Practical indications for the prevention and management of SARS-CoV-2 in ambulatory dialysis patients: lessons from the first phase of the epidemics in Lombardy. There is still an urgent need to accelerate protocols that lead to the implementation of rapid point-of-care diagnostic testing and effective antiviral therapies. 2020-04-09
Action at a Distance: Geriatric Research during a Pandemic. Mobilize research platforms for patient needs: Leverage our relationships with participants and rapidly deploy novel clinical engagement techniques such as digital tools to intervene remotely and reduce the negative effects of social isolation on our participants. 2020-04-03
[CT imaging features of patients with different clinical types of coronavirus disease 2019 (COVID-19)]. A total of 67 patients diagnosed as COVID-19 by nucleic acid testing were included and divided into 4 groups according to the clinical staging based on Diagnosis and treatment of novel coronavirus pneumonia (Trial version 6). 2020-03-26
Coronavirus disease 2019 (COVID-19): update for anesthesiologists and intensivists March 2020. Diagnosis relies on PCR using specimens from the respiratory tract. 2020-03-26
Coronavirus disease 2019: initial chest CT findings. If these typical alterations are found, then the differential diagnosis of coronavirus disease 2019 must be considered. 2020-03-30
[Analysis on cluster cases of COVID-19 in Tianjin]. The interval from onset to diagnosis for the first case was longer than those of other cases in the familial clusters (Z=-2.406, P= 0.016). […] The intervals from onset to diagnosis were significant different among the family, working place and public place clusters (H=8.843, , P=0.012) , and there were also significant differences in onset time among the secondary cases (H=16.607, P=0.000) . Conclusions: In the surveillance of COVID-19 epidemic, special attention should be paid to the cases from same family, same work place, or other places where clustering are prone to occur, and the epidemiological investigation should be carried out timely to confirm the cluster. 2020-03-27
[Epidemiological analysis on 1 052 cases of COVID-19 in epidemic clusters]. The median of onset- diagnosis interval of the initial cases was 6 (3-9) days, and the median of onset-diagnosis interval of the secondary cases was 5 (3-8) days. Conclusions: Epidemic clusters of COVID-19 were common in many cities outside Wuhan and Hubei. […] After 4 February, the epidemic clusters were mainly caused by the first generation or second generation cases in local areas, and the time for diagnosis became shorter. 目的: 了解新型冠状病毒肺炎聚集性病例的流行病学特征,探讨家庭因素以及集体活动等对本病传播的影响。 2020-03-27
Temporal profiles of viral load in posterior oropharyngeal saliva samples and serum antibody responses during infection by SARS-CoV-2: an observational cohort study. Serological assay can complement RT-qPCR for diagnosis. 2020-04-16
CT image visual quantitative evaluation and clinical classification of coronavirus disease (COVID-19). ROC was used to test the diagnosis ability of TSS for severe-critical type. 2020-03-30
Imaging manifestations and diagnostic value of chest CT of coronavirus disease 2019 (COVID-19) in the Xiaogan area. Spiral CT is a sensitive examination method, which can be applied to make an early diagnosis and for evaluation of progression, with a diagnostic sensitivity and accuracy better than that of nucleic acid detection. 2020-04-10
Coronavirus Disease 2019 (COVID-19) Pandemic and Pregnancy. Here we present a review of COVID-19 in pregnancy, bringing together the various factors integral to the understanding of pathophysiology and susceptibility, diagnostic challenges with real-time reverse transcriptase polymerase chain reaction (RT-PCR) assays, therapeutic controversies, intrauterine transmission and maternal-fetal complications. 2020-03-28
The Role of the Global Health Development/Eastern Mediterranean Public Health Network and the Eastern Mediterranean Field Epidemiology Training Programs in Preparedness for COVID-19. However, some countries remain ill-equipped, have poor diagnostic capacity, and are in need of further capacity development in response to public health threats. 2020-04-03
Clinical characteristics of 113 deceased patients with coronavirus disease 2019: retrospective study. Among a cohort of 799 patients, 113 who died and 161 who recovered with a diagnosis of covid-19 were analysed. 2020-04-06
Modeling the epidemic dynamics and control of COVID-19 outbreak in China. The confirmation rate of Wuhan estimated by our model is 0.0643, substantially lower than that of Hubei excluding Wuhan (0.1914), and that of China excluding Hubei (0.2189), but it jumps to 0.3229 after February 12 when clinical evidence was adopted in new diagnosis guidelines. 2020-03-31
Experience of Clinical Management for Pregnant Women and Newborns with Novel Coronavirus Pneumonia in Tongji Hospital, China. Based on the New Diagnosis and Treatment Scheme for Novel Coronavirus Infected Pneumonia (Trial Edition 5), combined with our current clinical treatment experience, we recently proposed a revision of the first edition of “Guidance for maternal and fetal management during pneumonia epidemics of novel coronavirus infection in the Wuhan Tongji Hospital”. […] This article focused on the issues of greatest concern of pregnant women including severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection diagnostic criteria, inspection precautions, drug treatment options, indications and methods of termination of pregnancy, postpartum fever, breastfeeding considerations, mode of mother-to-child transmission, neonatal isolation and advice on neonatal nursing, to provide valuable experience for better management of SARS-CoV-2 infection in pregnant women and newborns. 2020-03-28
[Expert consensus on the management strategy of patients with hereditary ataxia during prevention and control of novel coronavirus pneumonia epidemic]. In view of the seriousness of the COVID-19 epidemic, a series of prevention and control measures adopted by the government have restricted the follow-up, diagnosis and treatment of patients by the hospitals, which has a great impact on their mental and physical health. 2020-04-02
Stability issues of RT-PCR testing of SARS-CoV-2 for hospitalized patients clinically diagnosed with COVID-19. We also found that the RT-PCR results from several tests at different points were variable from the same patients during the course of diagnosis and treatment of these patients. […] Our results indicate that in addition to the emphasis on RT-PCR testing, clinical indicators such as computed tomography images should also be used not only for diagnosis and treatment but also for isolation, recovery/discharge, and transferring for hospitalized patients clinically diagnosed with COVID-19 during the current epidemic. […] These results suggested the urgent needs for the standard of procedures of sampling from different anatomic sites, sample transportation, optimization of RT-PCR, serology diagnosis/screening for SARS-CoV-2 infection, and distinct diagnosis from other respiratory diseases such as fluenza infections as well. 2020-04-05
[Epidemiology, Treatment, and Epidemic Prevention and Control of the Coronavirus Disease 2019: a Review]. Meanwhile, rapid detection kit for serological monitoring of the virus in general population is expected so as to achieve early detection, early diagnosis, early isolation and early treatment. 2020-04-02
[Clinical Study and CT Findings of a Familial Cluster of Pneumonia with Coronavirus Disease 2019 (COVID-19)]. The epidemiological and clinical features could provide quicker diagnosis and better management for the COVID-19 infected patients. 2020-04-02
COVID-19 Outbreak and Surgical Practice: Unexpected Fatality in Perioperative Period. COVID-19 can complicate the perioperative course with diagnostic challenge and a high potential fatality rate. 2020-03-29
Antibody responses to SARS-CoV-2 in patients of novel coronavirus disease 2019. Combining RNA and antibody detections significantly improved the sensitivity of pathogenic diagnosis for COVID-19 (p<0.001), even in early phase of 1-week since onset (p=0.007). […] The findings provide strong empirical support for the routine application of serological testing in the diagnosis and management of COVID-19 patients. 2020-03-29
Quantitative Detection and Viral Load Analysis of SARS-CoV-2 in Infected Patients. The widely used reverse transcription PCR (RT-PCR) method has limitations for clinical diagnosis and treatment. 2020-03-29
Clinical analysis of pregnant women with 2019 novel coronavirus pneumonia. Therefore, the protective measures are necessary on admission; the instant CT scan and real-time reverse-transcriptase polymerase-chain-reaction assay should be helpful in early diagnosis and avoid cross-infection on the occasion that patients have fever and other respiratory signs. 2020-04-10
Advice on Standardized Diagnosis and Treatment for Spinal Diseases during the Coronavirus Disease 2019 Pandemic. Practical work experience in our spinal outpatient and emergency department during the COVID-19 pandemic is summarized in this article, with combined evidence-based medical evidence to explore a standardized process of diagnosis and treatment for spinal diseases. 2020-04-07
Surviving Sepsis Campaign: guidelines on the management of critically ill adults with Coronavirus Disease 2019 (COVID-19). The topics were: (1) infection control, (2) laboratory diagnosis and specimens, (3) hemodynamic support, (4) ventilatory support, and (5) COVID-19 therapy. 2020-04-02
Review article: gastrointestinal features in COVID-19 and the possibility of faecal transmission. Diarrhoea was the most common gastrointestinal symptom in children and adults, with a mean duration of 4.1 ± 2.5 days, and was observed before and after diagnosis. 2020-04-16
Detectable SARS-CoV-2 viral RNA in feces of three children during recovery period of COVID-19 pneumonia. All of these three cases experienced mild illness and recovered soon after the treatment, with the nucleic acid of throat swab turning negative within 14, 11, and 7 days after diagnosis, respectively. 2020-04-15
Art of performing dermoscopy during the times of coronavirus disease (COVID-19): Simple change in approach can save the day! Dermatoscope is a convenient diagnostic tool used by dermatologists in the diagnosis of skin, hair and nail disorders. 2020-03-30
Diagnosing COVID-19: The Disease and Tools for Detection. The aim of this review article is to inform the audience of diagnostic and surveillance technologies for SARS-CoV-2 and their performance characteristics. 2020-04-10
Timely Diagnosis and Treatment Shortens the Time to Resolution of Coronavirus Disease (COVID-19) Pneumonia and Lowers the Highest and Last CT Scores From Sequential Chest CT. OBJECTIVE. This study aims to assess correlations of the time from symptom onset to diagnosis and treatment with the time to disease resolution and CT scores as based on findings from sequential chest CT examinations. MATERIALS AND METHODS. Thirty patients with coronavirus disease (COVID-19) confirmed by reverse transcription-polymerase chain reaction analysis underwent chest CT examinations. […] The time from symptom onset to diagnosis and treatment was recorded for each patient, and on the basis of this information, patients with COVID-19 were divided into group 1 (patients for whom this interval was ≤ 3 days) and group 2 (those for whom this interval was > 3 days). […] The differences in age, sex, and last CT scores determined before discharge between the two groups were analyzed, and correlations of the time from symptom onset to diagnosis and treatment with the time to disease resolution as well as with the highest CT score also underwent statistical analysis. RESULTS. A total of 25 subjects were enrolled in the study. […] The time from symptom onset to diagnosis and treatment had a positive correlation with the time to disease resolution (r = 0.93; p = 0.000) as well as with the highest CT score (r = 0.83; p = 0.006). CONCLUSION. Timely diagnosis and treatment are key to providing a better prognosis for patients with COVID-19. 2020-03-31
Surviving Sepsis Campaign: Guidelines on the Management of Critically Ill Adults with Coronavirus Disease 2019 (COVID-19). The topics were: 1) infection control, 2) laboratory diagnosis and specimens, 3) hemodynamic support, 4) ventilatory support, and 5) COVID-19 therapy. 2020-03-31
Pathways for urology patients during the COVID-19 pandemic. Simplification of the diagnostic and staging pathway has to be prioritized in order to reduce hospital visits and consequently the risk of contagion. 2020-03-31
Evaluation of SARS-CoV-2 RNA shedding in clinical specimens and clinical characteristics of 10 patients with COVID-19 in Macau. Based on our data on SARS-CoV-2 RNA shedding in stool and the possibility of a lag in viral detection in NPS specimens, the assessment of both fecal and respiratory specimen is recommended to enhance diagnostic sensitivity, and also to aid discharge decision before the role of viral RNA shedding in stool is clarified. 2020-04-03
COVID-19: what has been learned and to be learned about the novel coronavirus disease. We will cover the basics about the epidemiology, etiology, virology, diagnosis, treatment, prognosis, and prevention of the disease. 2020-04-03
COVID-19 in a Patient Presenting with Syncope and a Normal Chest X-ray. Our unique case underscores the increasing diversity of COVID-19 presentations and potential for initial mis- diagnosis and delay in implementing proper precautions. 2020-04-01
Caution should be exercised for the detection of SARS-CoV-2, especially in the elderly. After patient recovery, a chest CT examination, combined with SARS-CoV-2 RNA detection, confirmed diagnosis. 2020-03-31
Asymptomatic and Human-to-Human Transmission of SARS-CoV-2 in a 2-Family Cluster, Xuzhou, China. These findings might also serve as a practical reference for clinical diagnosis and medical treatment. 2020-04-01
Dynamic change process of target genes by RT-PCR testing of SARS-Cov-2 during the course of a Coronavirus Disease 2019 patient. We report the dynamic change process of target genes by RT-PCR testing of SARS-Cov-2 during the course of a COVID-19 patient: from successive negative results to successive single positive nucleocapsid gene, to two positive target genes (orf1ab and nucleocapsid) by RT-PCR testing of SARS-Cov-2, and describe the diagnosis, clinical course, and management of the case. 2020-04-16
Diagnosis of the Coronavirus disease (COVID-19): rRT-PCR or CT? To evaluate the diagnostic value of computed tomography (CT) and real-time reverse-transcriptase-polymerase chain reaction (rRT-PCR) for COVID-19 pneumonia. […] For patients with a final confirmed diagnosis, clinical and laboratory data, in addition to CT imaging findings were evaluated. 2020-04-16
Evaluation of Nucleocapsid and Spike Protein-based ELISAs for detecting antibodies against SARS-CoV-2. Background: At present, PCR-based nucleic acid detection cannot meet the demands for coronavirus infectious disease (COVID-19) diagnosis.Methods: 214 confirmed COVID-19 patients who were hospitalized in the General Hospital of Central Theater Command of the People’s Liberation Army between January 18 and February 26, 2020, were recruited. […] Two Enzyme-Linked Immunosorbent Assay (ELISA) kits based on recombinant SARS-CoV-2 nucleocapsid protein (rN) and spike protein (rS) were used for detecting IgM and IgG antibodies, and their diagnostic feasibility was evaluated.Results: Among the 214 patients, 146 (68.2%) and 150 (70.1%) were successfully diagnosed with the rN-based IgM and IgG ELISAs, respectively; 165 (77.1%) and 159 (74.3%) were successfully diagnosed with the rS-based IgM and IgG ELISAs, respectively. […] The positive rate of rN-based and rS-based IgM and IgG ELISAs was less than 60% during the early stage of the illness 0-10 d.p.o., and that of IgM and IgG was obviously increased after 10 d.p.o.Conclusions: ELISA has a high sensitivity, especially for the detection of serum samples from patients after 10 d.p.o, it can be an important supplementary method for COVID-19 diagnosis. 2020-04-01
Coronavirus Disease 19 Infection Does Not Result in Acute Kidney Injury: An Analysis of 116 Hospitalized Patients from Wuhan, China. All these patients did not meet the diagnostic criteria of AKI. 2020-04-01
Experience of Diagnosing and Managing Patients in Oral Maxillofacial Surgery during the Prevention and Control Period of the New Coronavirus Pneumonia. As one of the busiest specialised hospitals in the world, the Department of Oral and Maxillofacial Surgery of Peking University School and Hospital of Stomatology summarised the experience with disease prevention and control and clinical recommendations on the examination, diagnosis and treatment processes, clinical management, healthcare personnel protection and disinfection amid the continued spread of the pandemic. 2020-04-02
Safety Recommendations for Evaluation and Surgery of the Head and Neck During the COVID-19 Pandemic. Because of the rapid spread of this disease through respiratory droplets, health care workers who come in close contact with the upper aerodigestive tract during diagnostic and therapeutic procedures, such as otolaryngologists-head and neck surgeons, are particularly at risk. 2020-04-01
Characteristics of Ocular Findings of Patients With Coronavirus Disease 2019 (COVID-19) in Hubei Province, China. Understanding ocular manifestations of patients with COVID-19 by ophthalmologists and others may facilitate the diagnosis and prevention of transmission of the disease. 2020-04-04
Diagnostic performance of chest CT to differentiate COVID-19 pneumonia in non-high-epidemic area in Japan. To evaluate the diagnostic performance of chest CT to differentiate coronavirus disease 2019 (COVID-19) pneumonia in non-high-epidemic area in Japan. […] Using a Likert scale and its receiver operating characteristic curve analysis, two radiologists (R1/R2) evaluated the diagnostic performance of the five CT criteria: (1) ground glass opacity (GGO)-predominant lesions, (2) GGO- and peripheral-predominant lesions, (3) bilateral GGO-predominant lesions; (4) bilateral GGO- and peripheral-predominant lesions, and (5) bilateral GGO- and peripheral-predominant lesions without nodules, airway abnormalities, pleural effusion, and mediastinal lymphadenopathy. […] The five CT criteria showed moderate to excellent diagnostic performance with area under the curves (AUCs) ranging 0.77-0.88 for R1 and 0.78-0.92 for R2. 2020-04-01
Headaches Associated With Personal Protective Equipment - A Cross-Sectional Study Among Frontline Healthcare Workers During COVID-19. Pre-existing primary headache diagnosis was present in about a third [46/158 (29.1%)] of respondents. […] A pre-existing primary headache diagnosis (OR = 4.20, 95% CI 1.48-15.40; P = .030) and combined PPE usage for >4 hours per day (OR 3.91, 95% CI 1.35-11.31; P = .012) were independently associated with de novo PPE-associated headaches. […] Since COVID-19 outbreak, 42/46 (91.3%) of respondents with pre-existing headache diagnosis either “agreed” or “strongly agreed” that the increased PPE usage had affected the control of their background headaches, which affected their level of work performance. 2020-04-13
Effect of delay in diagnosis on transmission of COVID-19. Delay in diagnosis and limited hospital resources lead to a rapid spread of COVID-19. […] In this study, we investigate the effect of delay in diagnosis on the disease transmission with a new formulated dynamic model. […] Sensitivity analyses and numerical simulations reveal that, improving the proportion of timely diagnosis and shortening the waiting time for diagnosis can not eliminate COVID-19 but can effectively decrease the basic reproduction number, significantly reduce the transmission risk, and effectively prevent the endemic of COVID-19, e.g., shorten the peak time and reduce the peak value of new confirmed cases and new infection, decrease the cumulative number of confirmed cases and total infection. 2020-04-09
The Role of Emergency Radiology in COVID-19: From Preparedness to Diagnosis. Emergency trauma radiology, although a relatively new subspecialty of radiology, plays a critical role in both the diagnosis/triage of acutely ill patients, but even more important in providing leadership and taking the lead in the preparedness of imaging departments in dealing with novel highly infectious communicable diseases and mass casualties. […] We discuss roles that community radiology clinics, outpatient radiology departments, and emergency radiology departments can play in the diagnosis of this disease. 2020-04-02
Implications for Online Management: Two Cases with COVID-19. Satisfactory outcome was observed in one mild case and one severe case of COVID-19 pneumonia after the use of the online/offline multidisciplinary quarantine observation form, online monitoring, and classified diagnosis and treatment, as well as strict compliance with quarantine measures. 2020-04-02
Protected Code Stroke: Hyperacute Stroke Management During the Coronavirus Disease 2019 (COVID-19) Pandemic. Furthermore, rapid and effective stroke care remains paramount to achieve maximal functional recovery for those needing admission and to triage care appropriately for those who may be presenting with neurological symptoms but have an alternative diagnosis. 2020-04-02
[An epidemiologic thinking on the diagnosis criteria of COVID-19]. The diagnosis of COVID-19 is based on the positive of etiological test. 2020-04-02
[Epidemiological characteristics of COVID-19 in Gansu province]. Also, the incubation period prolonged along with the epidemic stage (F=51.65, P<0.01), but the intervals between disease onset and hospital visit (F=5.32, P<0.01), disease onset and diagnosis (F=5.25, P<0.01) became shorter along with the epidemic stage. 2020-04-02
Recent progress in understanding 2019 novel coronavirus (SARS-CoV-2) associated with human respiratory disease: detection, mechanisms and treatment. To effectively implement epidemic prevention, early identification and diagnosis are critical to disease control. 2020-04-15
The epidemiology, diagnosis and treatment of COVID-19. Early diagnosis, quarantine, and supportive treatments are essential to cure patients. […] This paper reviews the literature on all available information about the epidemiology, diagnosis, isolation and treatments of COVID-19. 2020-04-09
Healthcare Digitalization and Pay-For-Performance Incentives in Smart Hospital Project Financing. Whereas diagnostic or infrastructural technology is an expensive investment with long-term payback, leapfrogging digital applications reduce contingent costs. “Digital” savings can be shared by key stakeholders with P4P schemes, incentivizing value co-creation patterns. 2020-04-02
Epidemiological analysis of COVID-19 and practical experience from China. Chinese medical staff have summarized a set of effective strategies and methods in the diagnosis and treatment of this disease that are worthy of reference for their international counterparts. 2020-04-10
Isolation and rapid sharing of the 2019 novel coronavirus (SARS-CoV-2) from the first patient diagnosed with COVID-19 in Australia. The ability to rapidly identify, propagate, and internationally share our SARS-CoV-2 isolate is an important step in collaborative scientific efforts to deal effectively with this international public health emergency by developing better diagnostic procedures, vaccine candidates, and antiviral agents. 2020-04-05
Guidelines for Laboratory Diagnosis of Coronavirus Disease 2019 (COVID-19) in Korea. COVID-19 is a severe acute respiratory syndrome Coronavirus 2 (SARS-CoV-2) infection, and real-time reverse transcription-PCR is currently the most reliable diagnostic method for COVID-19 around the world. […] These guidelines are based on other related domestic and international guidelines, as well as expert opinions and include the selection of test subjects, selection of specimens, diagnostic methods, interpretation of test results, and biosafety. 2020-04-02
A case of imported COVID-19 diagnosed by PCR-positive lower respiratory specimen but with PCR-negative throat swabs. A lower respiratory tract specimen should be obtained for better diagnosis of corona virus disease 2019, even in the absence of respiratory symptoms for patients with significant travel or exposure history. 2020-04-16
Case Report: Walking Pneumonia in Novel Coronavirus Disease (COVID-19): Mild Symptoms with Marked Abnormalities on Chest Imaging. Diagnosis in this patient was facilitated by chest imaging and repeat viral testing. […] Thus, chest imaging studies might enhance capabilities for early diagnosis of COVID-19 pneumonia. 2020-04-02
The Importance of Diagnostic Testing during a Viral Pandemic: Early Lessons from Novel Coronavirus Disease (COVID-19). The Importance of Diagnostic Testing during a Viral Pandemic: Early Lessons from Novel Coronavirus Disease (COVID-19). 2020-04-02
[Coinfection between dengue and covid-19: need for approach in endemic zones.] Thus leading to a delay in the diagnosis of COVID-19 infection and further spread of the virus, since in most cases of Dengue there are no warning signs and treatment is ambulatory. 2020-04-08
Global Telemedicine Implementation and Integration Within Health Systems to Fight the COVID-19 Pandemic: A Call to Action. The response strategy included early diagnosis, patient isolation, symptomatic monitoring of contacts as well as suspected and confirmed cases, and public health quarantine. 2020-04-09
Novel Coronavirus 2019 (2019-nCoV) Infection: Part I - Preparedness and Management in the Pediatric Intensive Care Unit in Resource-limited Settings. Diagnosis involves a combination of clinical and epidemiological features with laboratory confirmation. 2020-04-16
Perinatal-Neonatal Management of COVID-19 Infection - Guidelines of the Federation of Obstetric and Gynecological Societies of India (FOGSI), National Neonatology Forum of India (NNF), and Indian Academy of Pediatrics (IAP). Perinatal period poses unique challenges and care of the mother-baby dyads requires special resources for prevention of transmission, diagnosis of infection and providing clinical care during labor, resuscitation and postnatal period. […] To provide recommendations for prevention of transmission, diagnosis of infection and providing clinical care during labor, resuscitation and postnatal period. […] A set of twenty recommendations are provided under the following broad headings: 1) pregnant women with travel history, clinical suspicion or confirmed COVID-19 infection; 2) neonatal care; 3) prevention and infection control; 4) diagnosis; 5) general questions. 2020-04-02
Current Status of Epidemiology, Diagnosis, Therapeutics, and Vaccines for Novel Coronavirus Disease 2019 (COVID-19). Currently, various diagnostic kits to test for COVID-19 are available and several repurposing therapeutics for COVID-19 have shown to be clinically effective. […] Here, we review the current status of epidemiology, diagnosis, treatment, and vaccine development for COVID-19. 2020-04-10
Proposal of a low-dose, long-pitch, dual-source chest CT protocol on third-generation dual-source CT using a tin filter for spectral shaping at 100 kVp for CoronaVirus Disease 2019 (COVID-19) patients: a feasibility study. To subjectively and objectively evaluate the feasibility and diagnostic reliability of a low-dose, long-pitch dual-source chest CT protocol on third-generation dual-source CT (DSCT) with spectral shaping at 100Sn kVp for COVID-19 patients. […] Qualitative analysis demonstrated significant reduction in motion artifacts (p = 0.031) with comparable diagnostic reliability between HD-DECT and LDCT. […] Ultra-low-dose, dual-source, fast CT protocol provides highly diagnostic images for COVID-19 with potential for reduction in dose and motion artifacts. 2020-04-14
First Mildly Ill, Non-Hospitalized Case of Coronavirus Disease 2019 (COVID-19) Without Viral Transmission in the United States - Maricopa County, Arizona, 2020. Contacts were persons exposed to the case on or after the day before case diagnostic specimen collection. […] Specimens collected 18 days after diagnosis tested positive. […] This report demonstrates that SARS-CoV-2 infection can cause mild illness and result in positive tests for up to 18 days after diagnosis, without evidence of transmission to close contacts. 2020-04-02
Diagnostic Value and Key Features of Computed Tomography in Coronavirus Disease 2019. To date, computed tomography (CT) findings have been recommended as major evidence for the clinical diagnosis of COVID-19 in Hubei, China. […] Since most patients with COVID-19 infection share typical imaging features, radiological examinations have an irreplaceable role in screening, diagnosis and monitoring treatment effects in clinical practice. 2020-04-03
Case Report on Early Diagnosis of COVID-19. Early diagnosis is one of the important contents in prevention and control. […] COVID-19 patients with early mild pneumonia often lack typical evidence to make a definitive diagnosis. […] Based on the analysis of the cases of 4 patients, this article finds that early diagnosis requires a combination of epidemiology, clinical manifestations, imaging, and etiology, with particular emphasis on epidemiology history and chest CT manifestations. 2020-04-03
Infectious diseases in children and adolescents in China: analysis of national surveillance data from 2008 to 2017. 4 959 790 Chinese students aged 6 to 22 years with a diagnosis of any of 44 notifiable infectious diseases. […] Diagnosis of, and deaths from, 44 notifiable infectious diseases. 2020-04-08
Primary care management of the coronavirus (COVID-19). Diagnosis is made by a RT-PCR test using respiratory secretions, usually nasopharyngeal and oropharyngeal swabs. 2020-04-08
Imaging and clinical features of patients with 2019 novel coronavirus SARS-CoV-2: A systematic review and meta-analysis. We aim to explore reliable evidence for the diagnosis and treatment of the COVID-19 by analyzing all the published studies by Chinese scholars on the clinical and imaging features in novel coronavirus pneumonia caused by SARS-CoV-2. 2020-04-10
Chest CT Features of COVID-19 in Rome, Italy. Background The standard for diagnosis of SARS-CoV-2 virus is reverse transcription polymerase chain reaction (RT-PCR) test, but chest CT may play a complimentary role in the early detection of COVID-19 pneumonia. […] Diagnostic performance of CT was calculated using RT-PCR as reference. 2020-04-03
The COVID-19: Role of Ambulatory Surgery Facilities in This Global Pandemic. This has led the United States to declare a national emergency and a ban on all elective diagnostic and therapeutic procedures, as well as elective surgery in inpatient and outpatient settings. […] However, these facilities may be able assist acute care hospitals, as essential (urgent and emergent) surgeries and diagnostic and therapeutic procedures will still need to be performed. 2020-04-03
COVID-19 in post-transplantation patients- report of two cases. After the diagnosis of COVID-19, immunosuppressive agents were discontinued and methylprednisolone with prophylactic antibiotics were initiated, however, the lung injury progressed. 2020-04-03
Characterization of the Humoral Immune Response to Porcine Epidemic Diarrhea Virus Infection under Experimental and Field Conditions Using an AlphaLISA Platform. In the absence of effective vaccines, infection prevention and control through diagnostic testing and quarantine are critical. […] Early detection and differential diagnosis of PEDV infections increase the chance of successful control of the disease. […] Particularly, the bridge assay constitutes a rapid diagnostic that substantially improves upon the “time to result” metric of currently available immunoassays. 2020-04-06
Primary stratification and identification of suspected Corona virus disease 2019 (COVID-19) from clinical perspective by a simple scoring proposal. In this Commentary, we would like to comment on the article titled “A rapid advice guideline for the diagnosis and treatment of 2019 novel coronavirus (2019-nCoV) infected pneumonia (standard version)” as a featured article in Military Medical Research. 2020-04-10
Updating the diagnostic criteria of COVID-19 “suspected case” and “confirmed case” is necessary. On 6 February 2020, our team had published a rapid advice guideline for diagnosis and treatment of 2019 novel coronavirus (2019-nCoV) infection, and this guideline provided our experience and make well reference for fighting against this pandemic worldwide. […] However, the coronavirus disease 2019 (COVID-19) is a new disease, our awareness and knowledge are gradually increasing based on the ongoing research findings and clinical practice experience; hence, the strategies of diagnosis and treatment are also continually updated. […] In this letter, we answered one comment on our guideline and provided the newest diagnostic criteria of “suspected case” and “confirmed case” according to the latest Diagnosis and Treatment Guidelines for COVID-19 (seventh version) that issued by the National Health Committee of the People’s Republic of China. 2020-04-10
The Laboratory Diagnosis of COVID-19 Infection: Current Issues and Challenges. This commentary covers current issues and challenges for the laboratory diagnosis of infections caused by SARS-CoV-2. […] In the pre-analytical stage, collecting the proper respiratory tract specimen at the right time from the right anatomic site is essential for a prompt and accurate molecular diagnosis of COVID-19. […] In the analytic stage, real-time RT-PCR assays remain the molecular test of choice for the etiologic diagnosis of SARS-CoV-2 infection while antibody-based techniques are being introduced as supplemental tools. […] Finally, random access, integrated devices available at the point of care with scalable capacities will facilitate the rapid and accurate diagnosis and monitoring of SARS-CoV-2 infections and greatly assist in the control of this outbreak. 2020-04-04
Pulmonary High-Resolution Computed Tomography (HRCT) Findings of Patients with Early-Stage Coronavirus Disease 2019 (COVID-19) in Hangzhou, China. Thus, suspected cases need to be closely monitored, and epidemiological history and clinical laboratory examination should also be considered during diagnosis. 2020-04-09
Potential false-negative nucleic acid testing results for Severe Acute Respiratory Syndrome Coronavirus 2 from thermal inactivation of samples with low viral loads. Nucleic acid testing (NAT) has played an important role in patient diagnosis and management of COVID-19. 2020-04-04
Hospital surge capacity in a tertiary emergency referral centre during the COVID-19 outbreak in Italy. We had a dedicated task force that identified a response plan, which included: (1) establishment of dedicated, cohorted intensive care unit(s) (ICU) for COVID-19-positive patients; (2) design of appropriate procedures for pre-triage, diagnosis and isolation of suspected and confirmed cases; and (3) training of all staff to work in the dedicated ICU in personal protective equipment use and patient management. 2020-04-04
A comparative-descriptive analysis of clinical characteristics in 2019-Coronavirus-infected children and adults. In summary, knowledge of these differences between children and adults will not only be helpful for the clinical diagnosis of 2019 novel coronavirus disease (COVID-19), but also for a future discussion on age-specific coronavirus infection. 2020-04-06
About the origin of the first two Sars-CoV-2 infections in Italy: inference not supported by appropriate sequence analysis. The diagnosis was performed by the virology team under direction of Maria R. 2020-04-06
Will plant-made biopharmaceuticals play a role in the fight against COVID-19? Plant biotechnology offers potential solutions to this pandemic through the development of low-cost vaccines and antibodies useful for therapy, prophylaxis, and diagnosis. 2020-04-16
A Mobile Health Platform to Disseminate Validated Institutional Measurements During the COVID-19 Outbreak: Utilization-Focused Evaluation Study. Using a third-party statistics tool, we anonymously monitored user activity as well as content utilization patterns since the diagnosis of the first case of SARS-CoV-2 in Switzerland on February 25, 2020. 2020-04-16
Gastrointestinal Manifestations of SARS-CoV-2 Infection and Virus Load in Fecal Samples from the Hong Kong Cohort and Systematic Review and Meta-analysis. We collected data from the cohort of patients with COVID-19 in Hong Kong (n=59; diagnosis from February 2 through Feb 29, 2020), and searched PubMed, Embase, Cochrane and three Chinese databases through March 11, 2020 according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. 2020-04-06
Severe Acute Respiratory Syndrome (SARS) and Coronavirus disease-2019 (COVID-19): From Causes to Preventions in Hong Kong. To prevent further outbreak of COVID-19, this article discusses the current understanding of COVID-19 and compares with the outbreak of SARS-CoV-2 in 2003 of Hong Kong from the causes, transmission, symptoms, diagnosis, treatments and preventions to study for an applicable measurement to control COVID-19. 2020-04-06
Diagnostic value and dynamic variance of serum antibody in coronavirus disease 2019. To investigate the diagnostic value of serological test and dynamitic variance of serum antibody in coronavirus disease 2019 (COVID-19). […] Viral serological test is an effective diagnostic means for SARS-CoV-2 infection. 2020-04-06
Impact of the COVID-19 pandemic on urology residency training in Italy. To provide insights on this issue, a 25-items online Survey was sent to all Italian residents one month after the first case of COVID-19 in Italy, to evaluate their routine involvement in “clinical” (on-call duty, outpatient visits, diagnostic procedures) and “surgical” (endoscopic, open and minimally invasive surgery) training activities before and during the COVID-19 period. 2020-04-07
The Role of Chest Imaging in Patient Management during the COVID-19 Pandemic: A Multinational Consensus Statement from the Fleischner Society. For these regions, healthcare delivery has been disrupted and compromised by critical resource constraints in diagnostic testing, hospital beds, ventilators, and healthcare workers who have fallen ill to the virus exacerbated by shortages of personal protective equipment. […] Thoracic imaging with chest radiography (CXR) and computed tomography (CT) are key tools for pulmonary disease diagnosis and management, but their role in the management of COVID-19 has not been considered within the multivariable context of the severity of respiratory disease, pre-test probability, risk factors for disease progression, and critical resource constraints. 2020-04-08
An evidence-based framework for priority clinical research questions for COVID-19. From the research objectives for SARS-CoV and MERS-CoV, ten themes in the literature were identified: Clinical characterisation, prognosis, diagnosis, clinical management, viral pathogenesis, epidemiological characterisation, infection prevention and control/transmission, susceptibility, psychosocial, and aetiology. […] For COVID19, some information on clinical presentation, diagnostic testing, and aetiology is available but many clinical research gaps have yet to be filled. 2020-04-15
Daily Situation Report on Coronavirus disease (COVID-19) in Iran; March 17, 2020. Where needed, clients are referred to 16-hour treatment clinics, which are specifically set up for the diagnosis and treatment of the disease, to the hospitals, or will be treated at home. 2020-04-09
Epidemiological and Clinical Aspects of COVID-19; a Narrative Review. Accordingly, our narrative review appraised epidemiological and clinical aspects of the disease including genetic diversity of coronavirus genus, mode of transmission, incubation period, infectivity, pathogenicity, virulence, immunogenicity, diagnosis, surveillance, clinical case management and also successful measures for preventing its spread in some communities. 2020-04-09
Laboratory Parameters in Detection of COVID-19 Patients with Positive RT-PCR; a Diagnostic Accuracy Study. This diagnostic accuracy study was conducted on suspected COVID-19 patients, who presented to Behpooyan Clinic Medical center in Tehran (Iran) from 22 February to 14 March, 2020. 2020-04-09
Novel coronavirus infection in children outside of Wuhan, China. Children who have a familial clustering or have a family member with a definite diagnosis should be reported to ensure a timely diagnosis. 2020-04-07
Risk of nosocomial transmission of coronavirus disease 2019: an experience in a general ward setting in Hong Kong. To describe an outbreak investigation of a patient with COVID-19 who was nursed in an open cubicle of a general ward before the diagnosis was made. 2020-04-09
COVID-19 Outbreak: An Overview. Highly sensitive and specific diagnostic assays are key to case identification, contact tracing, identification of the animal source, and implementation of control measures. 2020-04-07
Nuclear medicine in SARS-CoV-2 pandemia: 18F-FDG-PET/CT to visualize COVID-19. Diagnosis relies on clinical presentation, exposure history, PCR using specimens from the respiratory tract together with computed tomography (CT) imaging. 2020-04-07
Wearable Cardiorespiratory Monitoring Employing a Multimodal Digital Patch Stethoscope: Estimation of ECG, PEP, LVETand Respiration Using a 55 mm Single-Lead ECG and Phonocardiogram. ECG-derived respiration techniques were used in conjunction with a novel, phonocardiogram-derived respiration approach to extract respiratory parameters. 2020-04-10
In Vitro Diagnostic Assays for COVID-19: Recent Advances and Emerging Trends. There have been tremendous advances in in vitro diagnostic (IVD) assays for coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). […] A wide range of serology immunoassays (IAs) have also been developed that complement the molecular assays for the diagnosis of COVID-19. […] However, the performance of IVD assays needs to be critically evaluated before they are employed for the clinical diagnosis of COVID-19. 2020-04-08
Custom-made 3D-printed face masks in case of pandemic crisis situations with a lack of commercially available FFP2/3 masks. A proof of concept (PoC) and prototype are presented, demonstrating a reusable custom-made three-dimensionally (3D) printed face mask based on materials and techniques (3D imaging and 3D printing) with global availability. 2020-04-16
Ocular manifestations of a hospitalised patient with confirmed 2019 novel coronavirus disease. However, conjunctival sampling might not be useful for early diagnosis because the virus may not appear initially in the conjunctiva. 2020-04-08
Prediction models for diagnosis and prognosis of covid-19 infection: systematic review and critical appraisal. Three models were identified for predicting hospital admission from pneumonia and other events (as proxy outcomes for covid-19 pneumonia) in the general population; 18 diagnostic models for detecting covid-19 infection (13 were machine learning based on computed tomography scans); and 10 prognostic models for predicting mortality risk, progression to severe disease, or length of hospital stay. […] C index estimates ranged from 0.73 to 0.81 in prediction models for the general population (reported for all three models), from 0.81 to more than 0.99 in diagnostic models (reported for 13 of the 18 models), and from 0.85 to 0.98 in prognostic models (reported for six of the 10 models). […] Finally, studies should adhere to the TRIPOD (transparent reporting of a multivariable prediction model for individual prognosis or diagnosis) reporting guideline. 2020-04-10
Infants Born to Mothers With a New Coronavirus (COVID-19). One had rashes at birth but was discharged without parental consent for a diagnostic test. 2020-04-10
A case report of COVID-19 with false negative RT-PCR test: necessity of chest CT. The definite diagnosis of corona virus disease 2019 (COVID-19) is based on the viral isolation or positive result of polymerase chain reaction (PCR) from sputum, or nasal swab, or throat swab. 2020-04-08
Intravenous Anakinra for Macrophage Activation Syndrome May Hold Lessons for Treatment of Cytokine Storm in the Setting of Coronavirus Disease 2019. Management depends on the recognized diagnosis. 2020-04-09
[Coronavirus and COVID-19 : focus on a galopping pandemic]. The diagnosis is most often based on the detection of the viral genome in the nasopharynx by molecular biology methods. […] Le diagnostic repose, le plus souvent, sur la détection du génome viral au niveau du nasopharynx par des méthodes de biologie moléculaire. 2020-04-09
Policies and Guidelines for COVID-19 Preparedness: Experiences from the University of Washington. Radiology departments play a critical role in policy and guideline development both for the department and for the institutions, specifically in planning diagnostic screening, triage, and management of patients. 2020-04-08
Severe Acute Respiratory Syndrome Coronavirus 2-Specific Antibody Responses in Coronavirus Disease 2019 Patients. Although molecular diagnostic tests were rapidly developed, serologic assays are still lacking, yet urgently needed. […] Overall, the validated assays described can be instrumental for detection of SARS-CoV-2-specific antibodies for diagnostic, seroepidemiologic, and vaccine evaluation studies. 2020-04-08
[Clinical experience of high-flow nasal cannula oxygen therapy in severe corona virus disease 2019 (COVID-19) patients]. High-flow nasal cannula (HFNC) has been utilized widely due to its superiority over other non-invasive respiratory support techniques. 2020-04-10
[Treatment experience of burn patients combined with inhalation injury during epidemic period of Corona Virus Disease 2019]. After admission, 6 patients were given routine treatment, the medical staffs paid attention to the protection and screened COVID-19 according to the diagnosis and treatment plan of COVID-19. 2020-04-08
A Comprehensive Literature Review on the Clinical Presentation, and Management of the Pandemic Coronavirus Disease 2019 (COVID-19). Furthermore, the limitations and statistical strength of the diagnostic tools currently in clinical practice are evaluated. 2020-04-11
Expert consensus from the Italian Society for Colposcopy and Cervico-Vaginal Pathology (SICPCV) for colposcopy and outpatient surgery of the lower genital tract during the COVID-19 pandemic. In the context of the COVID-19 pandemic, patients need to be evaluated within 2-4 weeks in the following cases: cytology result of “squamous cell carcinoma,” “atypical glandular cells, favor neoplastic,” “endocervical adenocarcinoma in situ,” or “adenocarcinoma”; histopathological diagnosis of suspected invasion from cervical/vaginal biopsy, or invasive disease after a cervical excision procedure, vaginal excision, or vulvar biopsy/excision; sudden onset of strongly suggestive symptoms for malignancy. 2020-04-09
COVID-19 pandemic: Effects and evidence-based recommendations for otolaryngology and head and neck surgery practice. For any care or intervention in the upper aerodigestive tract region, irrespective of the setting and a confirmed diagnosis (eg, rhinoscopy or flexible laryngoscopy in the outpatient setting and tracheostomy or rigid endoscopy under anesthesia), it is strongly recommended that all health care personnel wear personal protective equipment such as N95, gown, cap, eye protection, and gloves. 2020-04-15
[Covid-19 diagnosis : clinical recommendations and performance of nasopharyngeal swab-PCR]. The Covid-19 pandemic imposes new diagnostic strategies in order to optimize the medical care of our patients. 2020-04-13
Survey of COVID-19 Disease Among Orthopaedic Surgeons in Wuhan, People’s Republic of China. Diagnostic Level IV. 2020-04-09
Co-infection of Coronavirus Disease 2019 and Influenza A: A Report from Iran. They were referred to the intended centers for COVID-19 diagnosis and management of Shiraz University of Medical Sciences in southern Iran. 2020-04-14
COVID19 Prevention & Care; A Cancer Specific Guideline. Therefore, cancer patients require higher level measures for preventing and treating infectious diseases. furthermore, cancer patients may bear additional risk due to the restriction of access to the routine diagnostic and therapeutic services during such epidemic. […] This article provides the recommendations and possible actions that should be considered by patients, their caregivers and families, physician, nurses, managers and staff of medical centers involved in cancer diagnosis and treatment. […] We pursued two major goals in our recommendations: first, limiting the exposure of cancer patients to medical environments and second, modifying the treatment modalities in a manner that reduces the probability of myelosuppression such as delaying elective diagnostic and therapeutic services, shortening the treatment course, or prolonging the interval between treatment courses. 2020-04-14
Epidemiology and Clinical Characteristics of COVID-19. Recently, accurate RNA detection has been decisive for the diagnosis of COVID-19. 2020-04-14
Improved Early Recognition of Coronavirus Disease-2019 (COVID-19): Single-Center Data from a Shanghai Screening Hospital. The number of infected people is rapidly increasing, while the diagnostic method of COVID-19 is only by nucleic acid testing. […] To explain the epidemiological characteristics, clinical features, imaging manifestations and to judge diagnostic value of COVID-19 by analyzing the clinical data of COVID-19 suspected and confirmed patients in a non-outbreak, Shanghai, China. 2020-04-14
Rapid Sentinel Surveillance for COVID-19 - Santa Clara County, California, March 2020. At the time the investigation began, testing guidance recommended focusing on persons with clinical findings of lower respiratory illness and travel to an affected area or an epidemiologic link to a laboratory-confirmed COVID-19 case, or on persons hospitalized for severe respiratory disease and no alternative diagnosis (1). 2020-04-10
Intensive care management of coronavirus disease 2019 (COVID-19): challenges and recommendations. Streamlining of workflows for rapid diagnosis and isolation, clinical management, and infection prevention will matter not only to patients with COVID-19, but also to health-care workers and other patients who are at risk from nosocomial transmission. 2020-04-09
High-resolution Chest CT Features and Clinical Characteristics of Patients Infected with COVID-19 in Jiangsu, China. Clinical performances of patients with COVID-19, mostly with epidemiologic history and typical symptoms, were critical valuable in the diagnosis of the COVID-19. 2020-04-11
Role of Tissue Engineering in COVID-19 and Future Viral Outbreaks. In light of the current novel coronavirus (COVID-19) pandemic, as well as other viral outbreaks in the 21st century, there is a dire need for new diagnostic and therapeutic strategies to combat infectious diseases worldwide. 2020-04-15
Coronavirus Disease (COVID-19) in Children - What We Know So Far and What We Do Not? Diagnosis is by Reverse transcriptase-Polymerase chain reaction (RT-PCR) testing of upper or lower respiratory tract secretions. 2020-04-10
[Roles of multidisciplinary team (MDT) in diagnosis and treatment of suspected cases of corona virus disease 2019 (COVID-19)]. To analyze the roles of multidisciplinary team (MDT) in the diagnosis and treatment of suspected cases of corona virus disease 2019 (COVID-19). […] The efficiency of diagnosis and treatment for suspected COVID-19 patients can be improved under MDT mode, particularly for complicated and refractory cases. 2020-04-13
Clinical manifestation, diagnosis, prevention and control of SARS-CoV-2 (COVID-19) during the outbreak period. This review summarizes current strategies on the diagnosis. […] The SARS-CoV-2 causes changes in blood cells and factors and makes lung abnormalities in patients, which can be detected by serological, molecular, and radiological techniques by detecting these changes and injuries. 2020-04-15
Neurologic Manifestations of Hospitalized Patients With Coronavirus Disease 2019 in Wuhan, China. The study included 214 consecutive hospitalized patients with laboratory-confirmed diagnosis of severe acute respiratory syndrome coronavirus 2 infection. […] During the epidemic period of COVID-19, when seeing patients with neurologic manifestations, clinicians should suspect severe acute respiratory syndrome coronavirus 2 infection as a differential diagnosis to avoid delayed diagnosis or misdiagnosis and lose the chance to treat and prevent further transmission. 2020-04-14
COVID-19 with Different Severity: A Multi-center Study of Clinical Features. Patients were divided into four groups according to age and into three groups (moderate, severe, and critical group) according to the fifth version of the guidelines issued by the National Health Commission of China on Diagnosis and Treatment of COVID-19. 2020-04-10
COVID-19 Autopsies, Oklahoma, USA. The diagnosis of coronavirus disease 2019 (COVID-19) was confirmed by real-time reverse transcriptase polymerase chain reaction testing on postmortem swabs. 2020-04-10
Point-of-care lung ultrasound in patients with COVID-19 - a narrative review. Compared to other monitoring modalities, such as auscultation or radiographic imaging, we argue lung ultrasound has high diagnostic accuracy, is ergonomically favourable and has fewer infection control implications. 2020-04-10
Telemedicine in Liver Disease and Beyond: Can the COVID-19 Crisis Lead to Action? Telemedicine, defined as the delivery of health care services at a distance using electronic means for diagnosis and treatment, holds tremendous promise to increase access to broadly specialty care. 2020-04-10
The Role of Chest Imaging in Patient Management during the COVID-19 Pandemic: A Multinational Consensus Statement from the Fleischner Society. For these regions, healthcare delivery has been disrupted and compromised by critical resource constraints in diagnostic testing, hospital beds, ventilators, and healthcare workers who have fallen ill to the virus exacerbated by shortages of personal protective equipment. […] Thoracic imaging with chest radiography (CXR) and computed tomography (CT) are key tools for pulmonary disease diagnosis and management, but their role in the management of COVID-19 has not been considered within the multivariable context of the severity of respiratory disease, pre-test probability, risk factors for disease progression, and critical resource constraints. 2020-04-16
Development of Reverse Transcription Loop-mediated Isothermal Amplification (RT-LAMP) Assays Targeting SARS-CoV-2. Diagnosis of COVID-19 is currently performed by RT-qPCR methods, but the capacity of RT-qPCR methods is limited by its requirement of high-level facilities and instruments. 2020-04-13
Rapid and visual detection of 2019 novel coronavirus (SARS-CoV-2) by a reverse transcription loop-mediated isothermal amplification assay. To describe the availability of this method in clinical diagnosis, we collected 130 specimens from patients with clinically suspected SARS-CoV-2 infection. 2020-04-13
Infection Control against COVID-19 in Departments of Radiology. Chest radiography and chest CT are frequently used to support the diagnosis of COVID-19 infection. 2020-04-14
Cancer Care Goes Virtual in Response to COVID-19. Amid concerns over the spread of COVID-19, oncology practices have “gone virtual,” with video appointments scheduled for any service that does not require diagnostic testing or treatment. 2020-04-11
Clinical evaluation of the cobas SARS-CoV-2 test and a diagnostic platform switch during 48 hours in the midst of the COVID-19 pandemic. Laboratories are currently witnessing extraordinary demand globally for sampling devices, reagents, consumables, and diagnostic instruments needed for timely diagnosis of SARS-CoV-2 infection. […] To meet diagnostic needs as the pandemic grows, the US Food and Drug Administration (FDA) recently granted several commercial SARS-CoV-2 tests Emergency Use Authorization (EUA), but manufacturer-independent evaluation data are scarce. […] Immediate prospective head-to-head comparative evaluation followed on 502 samples, and the diagnostic approaches showed overall percent agreement of 99.6% and a kappa value of 0.98. […] Under the extraordinary circumstances that laboratories are facing worldwide, a safe diagnostic platform switch is feasible in only 48 hours and in the midst of the COVID-19 pandemic if carefully planned and executed. 2020-04-11
Management of COVID-19 in patients after liver transplantation: Beijing working party for liver transplantation. It is urgent to set up guidelines for the prevention, diagnosis, and treatment of COVID-19 in liver transplant recipients. 2020-04-11
First case of COVID-19 complicated with fulminant myocarditis: a case report and insights. The patient conformed to the diagnostic criteria of the Chinese expert consensus statement for fulminant myocarditis. 2020-04-11
Feto-placental surgeries during the covid-19 pandemic: starting the discussion. For patients, concerns about Severe Acute Respiratory Syndrome-Corona Virus 2 (SARS-CoV2) will add to the anxiety caused by the diagnosis of a serious fetal anomaly, and for fetal medicine teams the situation gets more complex. 2020-04-11
Practical Guidance for Managing EMG Requests and Testing during the COVID-19 Pandemic. The COVID-19 pandemic has necessitated cancelation of elective or non-urgent contact with the healthcare system, including non-urgent nerve conduction studies and electromyography (electrodiagnostic [EDX] studies). 2020-04-11
Classification system and case definition for SARS-CoV-2 infection in pregnant women, fetuses, and neonates. There are limitations associated with sensitivity and specificity of diagnostic tests used and classification of patients based on test results has also been questioned. 2020-04-11
SAA is a biomarker to distinguish the severity and prognosis of Coronavirus Disease 2019 (COVID-19). Monitoring dynamic changes of SAA, combined with CT imaging could be valuable in diagnosis and treatment of COVID-19. 2020-04-14
Diarrhea during COVID-19 infection: pathogenesis, epidemiology, prevention and management. We searched on PubMed, EMBASE, and Web of Science up to March 2020 to identify studies documenting diarrhea and mechansism of intestinal inflammation in patients with confirmed diagnosis of SARS-CoV-2 infection. […] Increasing evidence indicates possible fecal oral transmission, indicating the need for a rapid and effective modification of the screening and diagnostic algorithms. 2020-04-13
COVID-19 and diabetes: Knowledge in progress. We searched for articles in PubMed and Google Scholar databases till 02 April 2020, with the following keywords: “SARS-CoV-2”, “COVID-19”, “infection”, “pathogenesis”, “incubation period”, “transmission”, “clinical features”, “diagnosis”, “treatment”, “diabetes”, with interposition of the Boolean operator “AND”. 2020-04-16
Anesthesia Management and Perioperative Infection Control in Patients With the Novel Coronavirus. The latter leads to an acceptable choice of materials and techniques for personal protection and prevention of cross-contamination to other patients and staff. […] The authors have presented a protocolized approach that uses diagnostic criteria to clearly define benchmarks from the medical history along with clinical symptoms and laboratory tests. […] Patients can then be rapidly assigned into 1 of 3 risk categories that direct the choice of protective materials and/or techniques. 2020-04-16
Clinical and computed tomographic (CT) images characteristics in the patients with COVID-19 infection: What should radiologists need to know? There were some typical CT features for diagnosis of COVID-19 pneumonia. 2020-04-13
[Rapid establishment of traditional Chinese medicine prevention and treatment of 2019-nCoV based on clinical experience and molecular docking]. Taking full advantage of the clinical experience of traditional Chinese medicine(TCM) in preventing and controlling major epidemics such as SARS, it is an important mission for TCM to propose effective formula with immediate response and solid evidence by using modern biomedical knowledge and techniques(molecular docking assisted TCM formulation for short). 2020-04-14
[Study on screening potential traditional Chinese medicines against 2019-nCoV based on Mpro and PLP]. By combining the diagnosis and treatment scheme of Hunan province’s and angiotensin converting enzyme 2(ACE2) inhibitors screening from literature, present study also discussed the rational application of candidate herbs to this epidemic situation. 2020-04-14
[Study on treatment of “cytokine storm” by anti-2019-nCoV prescriptions based on arachidonic acid metabolic pathway]. In the end, we obtained the potential active prescriptions on &quot;cytokine storm&quot; according to the potential herbs in the &quot;National novel coronavirus pneumonia diagnosis and treatment plan(trial version sixth)&quot;. 2020-04-14
[Analysis on pattern of prescriptions and syndromes of traditional Chinese medicine for prevention and treatment of COVID-19]. To investigate the regularity of prescription and clinical syndromes by analyzing the diagnosis and treatment protocols of traditional Chinese medicine(TCM) for coronavirus disease 2019(COVID-19), so as to provide references for syndrome differentiation and relevant researches. […] The diagnosis and treatment protocols of COVID-19 published by national and regional health authorities were searched, and information was extracted in regard to disease stages, type of syndromes, and prescriptions, etc. […] A total of 26 diagnosis and treatment protocols of TCM for COVID-19 were retrieved after screening(including 1 national scheme and 25 regional ones), among which 16 contained aspects of both prevention and treatment, 7 only involved treatment contents and 3 were prevention schemes. […] There were many diagnosis and treatment protocols for COVID-19 have been published, which generally followed the national edition, through with certain personalities in different regional protocols. […] Along with the deepening recognition of COVID-19, the diagnosis and treatment protocols are still need further concretization and standardization. 2020-04-14
[Analysis of property and efficacy of traditional Chinese medicine in staging revention and treatment of coronavirus disease 2019]. This study collected prevention and treatment approaches of traditional Chinese medicine for COVID-19 released from the National Health Committee of China, 7 provinces and municipal health committees, the Chinese Medicine Administration and Handbook of Traditional Chinese Medicine Diagnosis and Treatment of COVID-19 between January 1 and February 18, 2020, and prescriptions prepared by 3 masters of Chinese medicine and 4 well-known Chinese medicine experts. 2020-04-14
[Research progress of intervention of Chinese herbal medicine and its active components on human coronavirus]. Chinese patent medicines and prescriptions in medical observation and clinical treatment were recommended in the &quot;pneumonia diagnosis and treatment plan for new coronavirus infection&quot;(trial version fifth) of the National Health Commission of the People’s Republic of China. 2020-04-14
Loopholes in Current Infection Control and Prevention Practices Against COVID-19 in Radiology Department and Improvement Suggestions. We recommend to set up an isolation zone for handling patients who do not meet the diagnostic criteria of COVID-19 but are not completely cleared of the possibility of infection. 2020-04-13
Coronavirus disease 2019: new things to know! " 1 which report the clinical features, diagnosis and treatment of the novel Coronavirus Disease 2019 (COVID-19). 2020-04-13
C-reactive protein correlates with CT findings and predicts severe COVID-19 early. The present study aimed to analyze the characteristics of severe COVID-19 and identify biomarkers for differential diagnosis and prognosis prediction. 2020-04-13
[Covid-19 in patients on dialysis: infection prevention and control strategies]. However, as Covid-19 is an emerging disease, more work is needed to improve prevention, diagnosis and treatment strategies. […] It is essential to avoid nosocomial spread; in order to control and reduce the rate of infections it is necessary to strengthen the management of medical and nursing personnel through the early diagnosis, isolation and treatment of patients undergoing dialysis treatment. 2020-04-16
Dual-Functional Plasmonic Photothermal Biosensors for Highly Accurate Severe Acute Respiratory Syndrome Coronavirus 2 Detection. Reliable laboratory diagnosis of the disease has been one of the foremost priorities for promoting public health interventions. […] The routinely used reverse transcription polymerase chain reaction (RT-PCR) is currently the reference method for COVID-19 diagnosis. […] In this work, a dual-functional plasmonic biosensor combining the plasmonic photothermal (PPT) effect and localized surface plasmon resonance (LSPR) sensing transduction provides an alternative and promising solution for the clinical COVID-19 diagnosis. […] This study gains insight into the thermoplasmonic enhancement and its applicability in the nucleic acid tests and viral disease diagnosis. 2020-04-16
Innovation in Response to the COVID-19 Pandemic Crisis. Here he considers the implications of exemplary innovations-virtual care, hospital at home, advances in diagnosis and therapy, virtual learning, and virtual clinical learning-for regulators, academic medical centers, faculty, and students. 2020-04-13
Incidental CT Findings Suspicious for Covid-19 Associated Pneumonia on Nuclear Medicine Exams: Recognition and Management Plan. It is critical for Nuclear Medicine physicians to develop diagnostic skills for timely recognition of typical findings of C-19AP on a localizing CT. 2020-04-13
Molecular immune pathogenesis and diagnosis of COVID-19. In this minireview, we provide a brief introduction of the general features of SARS-CoV-2 and discuss current knowledge of molecular immune pathogenesis, diagnosis and treatment of COVID-19 on the base of the present understanding of SARS-CoV and MERS-CoV infections, which may be helpful in offering novel insights and potential therapeutic targets for combating the SARS-CoV-2 infection. 2020-04-16
Diagnostic Testing for Severe Acute Respiratory Syndrome-Related Coronavirus-2: A Narrative Review. Diagnostic testing to identify persons infected with severe acute respiratory syndrome-related coronavirus-2 (SARS-CoV-2) infection is central to control the global pandemic of COVID-19 that began in late 2019. […] In a few countries, the use of diagnostic testing on a massive scale has been a cornerstone of successful containment strategies. […] Although excellent tools exist for the diagnosis of symptomatic patients in well-equipped laboratories, important gaps remain in screening asymptomatic persons in the incubation phase, as well as in the accurate determination of live viral shedding during convalescence to inform decisions to end isolation. […] Here, the authors review the current array of tests for SARS-CoV-2, highlight gaps in current diagnostic capacity, and propose potential solutions. 2020-04-13
SARS-CoV-2: Olfaction, Brain Infection, and the Urgent Need for Clinical Samples Allowing Earlier Virus Detection. Attempts at slowing the pandemic at this stage depend on the number and quality of diagnostic tests performed. 2020-04-13
Serological immunochromatographic approach in diagnosis with SARS-CoV-2 infected COVID-19 patients. The standard diagnostic approach that widely adopted in the clinic is nucleic acid detection by real-time RT-PCR. 2020-04-13
Graft cryopreservation does not impact overall survival allogeneic hematopoietic cell transplantation using post-transplant cyclophosphamide for GVHD prophylaxis. The two cohorts (cryopreserved versus fresh) were similar in patient age, KPS, diagnosis, DRI, HCT-comorbidity index, donor/graft source, and conditioning intensity. 2020-04-13
Novel Approach to Reduce Transmission of COVID-19 During Tracheostomy. With the high transmissibility of the virus, there has been an increasing concern for the development of techniques to perform surgical intervention while mitigating the risk for infecting hospital staff. 2020-04-15
COVID-19: From bench to bed side. Ample data is available to suggest the differences in etiology, transmission cycle, diagnosis, genetics, hosts, reproductive rates, clinical features, laboratory diagnosis and radiological features between SARS-CoV-1, MERS-CoV and SARS-CoV-2. 2020-04-15
Searching therapeutic strategy of new coronavirus pneumonia from angiotensin-converting enzyme 2: the target of COVID-19 and SARS-CoV. This article will summarize the role of ACE2 in multiple organ damage caused by COVID-19 and SARS-CoV, targeted blocking drugs against ACE2, and drugs that inhibit inflammation in order to provide the basis for subsequent related research, diagnosis and treatment, and drug development. 2020-04-14
What Is the Appropriate Use of Laparoscopy over Open Procedures in the Current COVID-19 Climate? Among surgeons worldwide, a concern with the use of minimally invasive techniques has been raised due to a proposed risk of viral transmission of the coronavirus disease of 2019 (COVID-19) with the creation of pneumoperitoneum. 2020-04-14
From the handling of an outbreak by an unknown pathogen in Wuhan to the preparedness and response in the face of the emergence of Covid-19 in Mexico. The publication of full-genomes of the newly identified coronavirus (initially called 2019-nCoV, now called SARS-CoV2) in public and private databases, of standardized diagnostic protocols and of the clinical-epidemiological information generated will allow addressing the Public Health Emergency of International Concern (PHEIC), declared on January 30 by the WHO. 2020-04-16
Computed Tomography Imaging of an HIV-infected Patient with Coronavirus Disease 2019 (COVID-19). This report provides reference for the diagnosis and treatment of HIV-infected patients with COVID-19. 2020-04-14
Significance of Serology Testing to Assist Timely Diagnosis of SARS-CoV-2 infections: Implication from a Family Cluster. Confirmative diagnosis of SARS-CoV-2 infections has been challenged due to unsatisfactory positive rate of molecular assays. […] Our results emphasized the significance of serology testing to assist timely diagnosis of SARS-CoV-2 infections, especially for COVID-19 close contacts screening. 2020-04-14
[Diagnostic imaging findings in COVID-19]. This is a review of diagnostic imaging findings in coronavirus disease-2019 (COVID-19). […] Initially the CT can be normal, and the diagnostic performance for COVID-19 is not optimal. 2020-04-15
The value of urine biochemical parameters in the prediction of the severity of coronavirus disease 2019. A viral nucleic acid test is used for the diagnosis of COVID-19, and some hematological indicators have been used in the auxiliary diagnosis and identification of the severity of COVID-19. 2020-04-14
A Commentary on Safety Precautions for Otologic Surgery during the COVID-19 Pandemic. Until preoperative diagnostic testing becomes standardized and readily available, elective cases should be deferred and emergent/urgent cases should be treated as high risk for COVID-19 exposure. 2020-04-14
Cloud-Based System for Effective Surveillance and Control of COVID-19: Useful Experiences From Hubei, China. The HHS was designed for the collection, integration, standardization, and analysis of COVID-19-related data from multiple sources, which includes a case reporting system, diagnostic labs, electronic medical records, and social media on mobile devices. 2020-04-14
The evidence of SARS-CoV-2 infection on ocular surface. This is a cross-sectional study of patients who received a COVID-19 diagnosis between December 30, 2019 and February 7, 2020 at Tongji Hospital. […] A total of 102 patients (48 Male [47%] and 54 Female [53%]) with clinical symptoms, Rt, and chest Computed Tomography (CT) abnormalities were identified with a clinical diagnosis of COVID-19. […] Of a total of 102 patients identified, 72 patients (36 men [50%] and 36 women [50%]; mean [SD] age, 58.68 [14.81] years) were confirmed to have COVID-19 by laboratory diagnosis with a SARS-CoV-2 RT-PCR assay. […] To lower the SARS-CoV-2 nosocomial infection, all health care professionals should wear protective goggles.The inefficient diagnostic method and the sampling time lag may contribute to the lower positive rate of conjunctival swab samples of SARS-CoV-2. 2020-04-14
Experience summary of a COVID-19 designated community hospital and its operation model. To summarize the administration model of a COVID-19 designated hospital transformed from a community hospital to improve the emergency capacity of community hospitals and the efficiency of diagnosis and treatment of medical staff in the COVID-19 pandemic. […] Its diagnosis and treatment model has completed the treatment of COVID- 19 patients successfully. 2020-04-15
Planning and coordination of the radiological response to the coronavirus disease 2019 (COVID-19) pandemic: the Singapore experience. As this is a respiratory infection, chest radiography and computed tomography (CT) are important imaging techniques in the work-up of this disease. […] We describe the response of radiology departments in Singapore to this pandemic, in terms of diagnosis, re-configuration of the department, re-organisation and segregation of staff, infection control, managerial, and leadership issues. 2020-04-15
COVID-19 pneumonia: A review of typical CT findings and differential diagnosis. Computed tomography (CT) can be used as an important complement for the diagnosis of COVID-19 pneumonia in the current epidemic context. […] In this review, we present the typical CT features of COVID-19 pneumonia and discuss the main differential diagnosis. 2020-04-15
Suspected myocardial injury in patients with COVID-19: Evidence from front-line clinical observation in Wuhan, China. We enrolled patients with confirmed diagnosis of COVID-19 retrospectively and collected heart-related clinical data, mainly including cardiac imaging findings, laboratory results and clinical outcomes. 2020-04-15
The Importance of Chest CT Scan in COVID-19. One of the challenges in managing COVID-19 is the identification of a swift, accessible, and reliable diagnostic modality that could serve as an alternative to a reverse-transcriptase polymerase chain reaction (RT-PCR). […] As of the writing of this paper, RT-PCR is still the recommended tool in diagnosing COVID-19, but the notion of a more prompt and accurate diagnostic tool is a possibility worth looking into. […] The objective of this case study is to investigate the importance and utility of chest computed tomography (CT) in the diagnosis of COVID-19, as increasing pieces of evidence suggest that chest CT could prove useful in the clinical pathway in diagnosing COVID-19. 2020-04-16
CT features of novel coronavirus pneumonia (COVID-19) in children. As the majority of patients infected with COVID-19 had chest CT abnormality, chest CT has become an important tool for early diagnosis of COVID-19 and monitoring disease progression. […] This review is mainly about the differences in clinical symptom spectrum, diagnosis of COVID-19, and CT imaging findings between adults and children, while highlighting the value of radiology in prevention and control of COVID-19 in pediatric patients. 2020-04-15
The epidemiology and clinical information about COVID-19. In this review, we summarized the epidemiological characteristics, clinical features, diagnosis, treatment, and prognosis of COVID-19. 2020-04-15
[Distributions of time, place, and population of novel coronavirus disease 2019 (COVID-19) from January 20 to February 10, 2020, in China]. The COVID-19 epidemic should be considered a global threat and the steps for control include early diagnosis and treatment, as well as isolation. 2020-04-15
[Coronavirus: from common cold to severe pulmonary failure]. Molecular diagnostic methods have been established in a very short time and a number of clinical studies on the effectiveness of different antiviral drugs are ongoing. 2020-04-15
Highlights of traditional Chinese medicine frontline expert advice in the China national guideline for COVID-19. As the epicentre of the initial outbreak, China has been updating the National COVID-19 Diagnostic and Treatment Guideline with up-to-date information about the disease. 2020-04-15
Recent advances and perspectives of nucleic acid detection for coronavirus. It is important to establish a quick standard diagnostic test for the detection of the infectious disease (COVID-19) to prevent subsequent secondary spread. […] Polymerase chain reaction (PCR) is regarded as a gold standard test for the molecular diagnosis of viral and bacterial infections with high sensitivity and specificity. […] It is anticipated that this will assist researchers and clinicians in developing better techniques for timely and effective detection of coronavirus infection. 2020-04-15
Application of refined management in the prevention and control of coronavirus disease 2019 epidemic in non-isolated areas of a general hospital. Based on refined management theory, we professionally developed the standards for prevention and control of COVID-19 in non-isolated areas, systematically implemented various prevention and control measures, performed gridding audit, effectively communicated among teams and between doctors and patients assisted by information techniques, and reported results for quality improvement. 2020-04-15
Chinese herbal Huo-Gu Formula for treatment of steroid-associated osteonecrosis of femoral head: a 14-years follow-up of convalescent SARS patients. All patients received oral HGF therapy for six months when they were confirmed the diagnosis of steroid-associated ONFH. 2020-04-15
Emergence of deadly severe acute respiratory syndrome coronavirus-2 during 2019-2020. We have also provided information about the classification, genome, proteins, clinical presentation of COVID-19, type of clinical specimens to be collected and diagnostic methods adopted to identify the respiratory illness. 2020-04-15
A living systematic review protocol for COVID-19 clinical trial registrations. Since the coronavirus disease 2019 (COVID-19) outbreak was identified in December 2019 in Wuhan, China, a strong response from the research community has been observed with the proliferation of independent clinical trials assessing diagnostic methods, therapeutic and prophylactic strategies. 2020-04-15
Progress and prospect on imaging diagnosis of COVID-19. The appearance of pneumonia is one of the major clues for the diagnosis, progress and therapeutic evaluation. 2020-04-15
Outcome of Coronavirus spectrum infections (SARS, MERS, COVID 1 -19) during pregnancy: a systematic review and meta-analysis. An overt diagnosis of pneumonia was made in 91.8% and the most common symptoms were fever (82.6%), cough (57.1%) and dyspnea (27.0%). 2020-04-15
Coronavirus Disease 2019 (COVID-19) Pneumonia in a Hemodialysis Patient. The diagnosis, infection control, and treatment of COVID-19 in hemodialysis patients are discussed in this report, and we conclude with recommendations for how a dialysis facility can respond to COVID-19 based on our experiences. 2020-04-15
Rapid Detection of COVID-19 Causative Virus (SARS-CoV-2) in Human Nasopharyngeal Swab Specimens Using Field-Effect Transistor-Based Biosensor. Because no specific drugs or vaccines for COVID-19 are yet available, early diagnosis and management are crucial for containing the outbreak. […] Thus, we have successfully fabricated a promising FET biosensor for SARS-CoV-2; our device is a highly sensitive immunological diagnostic method for COVID-19 that requires no sample pretreatment or labeling. 2020-04-15
Coinfection with COVID-19 and Coronavirus HKU1 - the critical need for repeat testing if clinically indicated. In general, respiratory viral co-infections are recognized more commonly today with the use of respiratory multiplex molecular diagnostic panels. […] A high degree of suspicion in this rapidly evolving outbreak is required in order to make the diagnosis. 2020-04-15
Mental Health Care Providers Dealing With Coronavirus Disease 2019 (COVID-19): What Is the Definition of a Case, How Is That Changing, and What Kinds of Tests Are Available? The goal of this column is to inform mental health care professionals about the evolving way the diagnosis of Coronavirus Disease 2019 (COVID-19) is being made, with emphasis on tests to assist in making the diagnosis and to determine the presence of antibodies to the virus. 2020-04-15
A Clinical Study of Noninvasive Assessment of Lung Lesions in Patients with Coronavirus Disease-19 (COVID-19) by Bedside Ultrasound. This study was conducted to explore the clinical value of noninvasive assessment of bedside ultrasound in the diagnosis of lung lesions of Coronavirus Disease-19. […] The ultrasound scores to evaluate mild, moderate and severe lung lesions exhibited sensitivity of 68.8 % (11/16), 77.8 % (7/9), 100.0 % (2/2), specificity of 85.7 % (12/14), 76.2 % (16/21), 92.9 % (26/28), and diagnostic accuracy of 76.7 % (23/30), 76.7 % (23/30), 93.3 % (28/30), respectively. […] Though the diagnostic efficacy of bedside ultrasound is relatively low for mild to moderate patients, it is high for severe patients. 2020-04-15
[Bronchoalveolar lavage fluid was used to diagnose two cases of 2019-nCoV infection]. The results showed that the positive rate of bronchoalveolar lavage for detection of new coronavirus nucleic acid was high, and bronchoalveolar lavage for suspected or confirmed new coronavirus pneumonia patients with negative detection of nucleic acid in pharynx swabs but still residual lung lesions was helpful for early diagnosis, treatment and prognosis. 2020-04-17
[CT imaging analysis of 33 cases with the 2019 novel coronavirus infection]. Objective: To explore the CT imaging features of the 2019 novel coronavirus (2019-nCoV) infection in order to summarize the imaging characteristics of the disease and improve the ability of imaging diagnosis and early diagnosis of the disease. Methods: From January 13, 2020 to January 31, 2020, a total of 33 patients with 2019-nCoV infection diagnosed and treated by Suzhou Fifth People’s Hospital were analyzed retrospectively, including 20 males and 13 females, with an average age of (50±12) years, ranging from 20 to 70 years old. […] CT images can indicate the diagnosis of COVID-19 and provide important basis for early detection and disease monitoring. 目的: 探讨新型冠状病毒(2019-nCoV)感染患者的肺部CT影像表现,总结其影像特征,提高对该病肺部影像诊断能力。 2020-04-17
Coronavirus Diseases (COVID-19) Current Status and Future Perspectives: A Narrative Review. We performed a narrative review to describe existing literature with regard to Corona Virus Disease 2019 (COVID-19) epidemiology, pathophysiology, diagnosis, management and future perspective. […] In particular, we focus on public health impact, pathophysiology and clinical manifestations, diagnosis, case management, emergency response and preparedness. 2020-04-21
[Clinical analysis of 150 cases of 2019 novel coronavirus infection in Nanyang City, Henan Province]. Objective: To analyze the epidemiological characteristics and clinical features of the patients with 2019-nCoV infection in Nanyang City, so as to provide evidence for clinical diagnosis and treatment. Methods: The epidemiology, clinical symptoms, atory and radiologic data of 150 patients with 2019-nCoV infection admitted to the designated hospitals in Nanyang City from January 24,2020 to February 16, 2020 were retrospectively analyzed. Results: The 150 patients with 2019 nCov infection consisted of 67 men and 83 women, and the median age was 45±16 years; 69 of them were the first generation case,60 of them were the second generation case, 6 of them were the third generation case,the median incubation period of the first generation case was 5.4±2.2 days, and the second generation case was 6.7±3.1 days, and the first-generation cases are the majority in severe patients (69%) . […] After active treatment, 45% of patients were discharged according to discharge standards. 33% of sever and critically ill patients were discharged, 49% of them were degraded hospitalization.The average length of hospitalization was 12±4 days. Conclusion: A history of epidemiological exposure, fever, chest CT with signs of pneumonia, normal or decreased WBC, and lymphocytopenia, eosinophilia are the clinical basis for the diagnosis of this disease, and most of the sever patients were the first generation cases. 2020-04-16
[Expert consensus on sleep study and non-invasive positive airway pressure therapy during the epidemic of coronavirus disease 2019]. Based on the characteristics of sleep-disordered breathing, this consensus elaborates on the recommendations from the following four aspects that include patient and medical staff education, optimization of diagnostic and treatment protocols, sterilization of medical devices and the environment, and control of hospital-acquired infection. 2020-04-16
[Screening for novel coronavirus related conjunctivitis among the patients with corona virus disease-19]. Conjunctival swab novel coronavirus nucleic acid test was performed on patients with clinical manifestation of conjunctivitis. Results: Only 3 of the 81 patients (3.70%) complained of eye discomfort, which appeared on the day 16.67±9.29 after the diagnosis of coronavirus disease-19. […] There was no evidence to support the diagnosis of novel coronavirus related conjunctivitis. 2020-04-16
[SARS-CoV-2 infection may result in appendicular syndrome: Chest CT scan before appendectomy]. An abdominal CT scan ruled out a diagnosis of appendicitis and a chest CT scan yielded a diagnosis of SARS-CoV-2 infection. 2020-05-07
The changing patter of COVID-19 in China: A tempo-geographic analysis of the SARS-CoV-2 epidemic. However, as the diagnosis criteria changed, a sudden increase (slope=5530) was observed on 12th Feb., which sharply decreased afterward (slope=-4898). 2020-04-30
Epidemiology of seasonal coronaviruses: Establishing the context for COVID-19 emergence. We analyzed routine diagnostic data for >70,000 episodes of respiratory illness tested molecularly for multiple respiratory viruses between 2005 and 2017. […] These findings highlight the importance of considering cocirculating viruses in the differential diagnosis of COVID-19. 2020-04-30
The role of imaging in 2019 novel coronavirus pneumonia (COVID-19). Imaging exams have been a main clinical diagnostic criteria for the 2019 novel coronavirus disease (COVID-19) in China. […] Imaging features of multiple patchy areas of ground glass opacity and consolidation predominately in the periphery of the lungs are characteristic manifestations on chest CT and extremely helpful in the early detection and diagnosis of this disease, which aids prompt diagnosis and the eventual control of this emerging global health emergency. […] • Imaging examination has become the indispensable means not only in the early detection and diagnosis but also in monitoring the clinical course, evaluating the disease severity, and may be presented as an important warning signal preceding the negative RT-PCR test results. 2020-04-30
COVID-2019: update on epidemiology, disease spread and management. Hence, the standard infection control techniques and preventive steps for healthy individuals and supportive care for the confirmed cases is the best available strategy to deal with current viral outbreak. . 2020-04-20
Global Preparedness Against COVID-19: We Must Leverage the Power of Digital Health. We provide several use cases for infection control, home-based diagnosis and screening, empowerment through information, public health surveillance and epidemiology, and leveraging crowd-sourced data. 2020-04-21
COVID-19: Recommended sampling sites at different stage of the disease. At present, it mainly relies on Real-time RT-PCR to detect SARS-CoV-2 virus nucleic acid collected from the clinical specimens of patients as the standard for diagnosis, discontinuation of quarantine and discharge.1,2 This article is protected by copyright. 2020-04-27
How to Guarantee the Best of Care to Patients with Cancer During the COVID-19 Epidemic: The Italian Experience. Patients who need to be hospitalized for cancer treatment were protected from potential SARS-CoV-2 infection by creating a dedicated diagnostic and therapeutic internal pathway for cancer treatment. 2020-04-27
Geospatial Hotspots Need Point-of-Care Strategies to Stop Highly Infectious Outbreaks: Ebola and Coronavirus. Context. Point-of-care testing (POCT), diagnostic testing at or near the site of patient care, is inherently spatial , that is, performed at points of need, and also intrinsically temporal , because it produces fast actionable results. […] The COVID-19 pandemic demonstrates unequivocally that governments must support POCT and multidisciplinary healthcare personnel must learn its principles, then adopt POC geospatial strategies, so that onsite diagnostic testing can ramp up to meet needs in times of crisis. 2020-04-16
Chest CT and Coronavirus Disease (COVID-19): A Critical Review of the Literature to Date. The purpose of this article is to critically review some of the most frequently cited studies on the use of CT for detecting COVID-19. CONCLUSION. To date, the radiology literature on COVID-19 has consisted of limited retrospective studies that do not substantiate the use of CT as a diagnostic test for COVID-19. 2020-04-16
Geographic Differences in COVID-19 Cases, Deaths, and Incidence - United States, February 12-April 7, 2020. Geographic differences in numbers of COVID-19 cases and deaths, cumulative incidence, and changes in incidence likely reflect a combination of jurisdiction-specific epidemiologic and population-level factors, including 1) the timing of COVID-19 introductions; 2) population density; 3) age distribution and prevalence of underlying medical conditions among COVID-19 patients (1-3); 4) the timing and extent of community mitigation measures; 5) diagnostic testing capacity; and 6) public health reporting practices. 2020-04-17
Saliva is a reliable tool to detect SARS-CoV-2. The role of saliva in COVID-19 diagnosis could not be limited to a qualitative detection of the virus, but it may also provide information about the clinical evolution of the disease. 2020-05-05
Radiological approaches to COVID-19 pneumonia The symptoms are undiagnostic, the results of viral nucleic acid detection method (PCR) can delay, so that chest computerized tomography is often key diagnostic test in patients with possible COVID-19 pneumonia. 2020-04-22
Crushing the curve, the role of national and international institutions and policy makers in COVID-19 pandemic The first patients may be lost without a proper diagnosis. 2020-04-22
Coronavirus Anxiety Scale: A brief mental health screener for COVID-19 related anxiety. Elevated CAS scores were found to be associated with coronavirus diagnosis, impairment, alcohol/drug coping, negative religious coping, extreme hopelessness, suicidal ideation, as well as attitudes toward President Trump and Chinese products. 2020-05-08
Saliva: potential diagnostic value and transmission of 2019-nCoV. This review summarizes diagnostic value of saliva for 2019-nCoV, possibly direct invasion into oral tissues, and close contact transmission of 2019-nCoV by saliva droplets, expecting to contribute to 2019-nCoV epidemic control. 2020-04-21
Genomic characterization of a novel SARS-CoV-2. Information on the variation of viruses is of considerable medical and biological impacts on the prevention, diagnosis, and therapy of infectious diseases. 2020-04-21
[Telemedicine in the fight against SARS-COV-2-opportunities and possible applications in otorhinolaryngology : Narrative review]. Neither image quality nor the handling of the technology are relevant obstacles to a reliable diagnosis. 2020-05-07
Prevention and control measures in radiology department for COVID-19. Radiological examinations were confirmed as effective methods for the screening and diagnosis of COVID-19. 2020-05-01
A diagnostic model for coronavirus disease 2019 (COVID-19) based on radiological semantic and clinical features: a multi-center study. Rapid and accurate diagnosis of coronavirus disease 2019 (COVID-19) is critical during the epidemic. […] We aim to identify differences in CT imaging and clinical manifestations between pneumonia patients with and without COVID-19, and to develop and validate a diagnostic model for COVID-19 based on radiological semantic and clinical features alone. […] Diagnostic efficacies of developed models were quantified by receiver operating characteristic curve. […] Besides ground-glass opacities (p = 0.032) and consolidation (p = 0.001) in the lung periphery, the lesion size (1-3 cm) is also significant for the diagnosis of COVID-19 (p = 0.027). […] Three diagnostic models achieved an area under the curve value as high as 0.986 (95% CI 0.966~1.000). […] The clinical and radiological semantic models provided a better diagnostic performance and more considerable net benefits. […] A model composed of radiological semantic and clinical features has an excellent performance for the diagnosis of COVID-19. […] • A diagnostic model for COVID-19 was developed and validated using radiological semantic and clinical features, which had an area under the curve value of 0.986 (95% CI 0.966~1.000) and 0.936 (95% CI 0.866~1.000) in the primary and validation cohorts, respectively. 2020-04-30
Clinical characteristics of COVID-19 in children compared with adults in Shandong Province, China. We reported on the epidemiological, clinical, laboratory, and radiological characteristics of children cases to help health workers better understand and provide timely diagnosis and treatment. 2020-05-29
COVID-19 in solid organ transplant recipients: A single-center case series from Spain. Median age at diagnosis was 71.0 ± 12.8 years, and the median interval since transplantation was 9.3 years. 2020-05-10
Case report: A kidney transplant patient with mild COVID-19. Here, we report the clinical features and our treatment approach for a kidney transplant patient with a diagnosis of COVID-19. 2020-05-22
Lung Base Findings of Coronavirus Disease (COVID-19) on Abdominal CT in Patients With Predominant Gastrointestinal Symptoms. OBJECTIVE. This series of patients presented to the emergency department (ED) with abdominal pain, without the respiratory symptoms typical of coronavirus disease (COVID-19), and the abdominal radiologist was the first to suggest COVID-19 infection because of findings in the lung bases on CT of the abdomen. CONCLUSION. COVID-19 infection can present primarily with abdominal symptoms, and the abdominal radiologist must suggest the diagnosis when evaluating the lung bases for typical findings. 2020-04-17
Diagnostic Performance of CT and Reverse Transcriptase-Polymerase Chain Reaction for Coronavirus Disease 2019: A Meta-Analysis. Background Recent studies have suggested that chest computed tomography (CT) scans could be used as a primary screening or diagnostic tool for coronavirus disease 2019 (COVID-19) in epidemic areas. […] Purpose To perform a meta-analysis to evaluate diagnostic performance measures, including predictive values, of chest CT and initial reverse transcriptase-polymerase chain reaction (RT-PCR). […] Meta-regression was performed to reveal the effect of potential explanatory factors on the diagnostic performance measures. 2020-04-17
Well-aerated Lung on Admitting Chest CT to Predict Adverse Outcome in COVID-19 Pneumonia. In comparison with clinical model containing only clinical parameters (AUC, 0.83), all three quantitative models showed higher diagnostic performance (AUC 0.86 for all models). 2020-04-27
What do urologists need to know: Diagnosis, treatment, and follow-up during COVID-19 pandemic. Laboratory diagnosis is required to confirm the diagnosis of COVID-19. […] In this review we provide guidance on the diagnosis and management of COVID-19, the influence it has on urological practice and consider the long-term implications that may be of consequence for years to come. 2020-05-20
Comparison of throat swabs and sputum specimens for viral nucleic acid detection in 52 cases of novel coronavirus (SARS-Cov-2)-infected pneumonia (COVID-19). Laboratory-based diagnostic tests utilized real-time reverse transcriptase polymerase chain reaction (RT-PCR) on throat samples. […] This study evaluated the diagnostic value to analyzing throat and sputum samples in order to improve accuracy and detection efficiency. […] The results can facilitate the selection of specimens and increase the accuracy of diagnosis. 2020-04-17
Analytical performances of a chemiluminescence immunoassay for SARS-CoV-2 IgM/IgG and antibody kinetics. Moreover, many patients can be asymptomatic, thus increasing the uncertainty of the diagnostic work-up. […] Laboratory tests play a pivotal role in the diagnosis and management of COVID-19, the current gold standard being real-time reverse transcription polymerase chain reaction (rRT-PCR) on respiratory tract specimens. […] However, the diagnostic accuracy of rRT-PCR depends on many pre-analytical and analytical variables. […] These data represent a pre-requisite for the appropriate utilization of specific antibodies for the diagnosis and management of COVID-19 patients. 2020-04-17
Digestive Symptoms in COVID-19 Patients With Mild Disease Severity: Clinical Presentation, Stool Viral RNA Testing, and Outcomes. These patients are more likely to test positive for viral RNA in stool, to have a longer delay before viral clearance, and to experience delayed diagnosis compared with patients with only respiratory symptoms. 2020-04-23
Detectable serum SARS-CoV-2 viral load (RNAaemia) is closely correlated with drastically elevated interleukin 6 (IL-6) level in critically ill COVID-19 patients. The patients were divided into three groups according to the “Diagnosis and Treatment of New Coronavirus Pneumonia (6th edition)” issued by the National Health Commission of China. 2020-04-30
Laboratory testing of SARS-CoV, MERS-CoV, and SARS-CoV-2 (2019-nCoV): Current status, challenges, and countermeasures. During the SARS-CoV and MERS-CoV epidemics, a variety of molecular and serological diagnostic assays were established and should be referred to for SARS-CoV-2. 2020-05-19
Assessment of the Angolan (CHERRT) Mobile Laboratory Curriculum for Disaster and Pandemic Response. This mobile RRT laboratory provides a mobile and rapid diagnostic resource when epidemic/pandemic resource allocation may need to be prioritized based on confirmed disease prevalence. 2020-05-20
Healthcare Ethics During a Pandemic. They also can address the common problems healthcare workers must overcome to continue working (ie, risk mitigation techniques). 2020-05-20
COVID-19 and acute coagulopathy in pregnancy. The laboratory derangements may be reminiscent of HELLP (hemolysis, elevated liver enzymes, low platelet count) syndrome, and thus knowledge of the COVID-19 relationship is paramount for appropriate diagnosis and management. 2020-05-26
Comparative computational analysis of SARS-CoV-2 nucleocapsid protein epitopes in taxonomically related coronaviruses. These evidence provide a molecular structural rationale for a potential role in conferring protection from SARS-CoV-2 infection and identifying potential candidates for the development of diagnostic tools and prophylactic-oriented strategies. 2020-04-20
People experiencing homelessness: Their potential exposure to COVID-19. Homeless people have less access to health care providers who could otherwise order diagnostic testing and, if confirmed, isolate them from others in coordination with local health departments. 2020-05-19
Portable chest X-ray in coronavirus disease-19 (COVID-19): A pictorial review. As the global pandemic of coronavirus disease-19 (COVID-19) progresses, many physicians in a wide variety of specialties continue to play pivotal roles in diagnosis and management. 2020-05-22
Consistency analysis of COVID-19 nucleic acid tests and the changes of lung CT. No unified diagnostic standard has been formulated. […] The initial diagnosis remains based on the positive of nucleic acid tests. […] In accordance with the latest COVID-19 diagnostic criteria, 69 patients diagnosed with COVID-19 treated in the infected V ward of Xiaogan Central Hospital from 2020/1/25 to 2020/2/6 were retrospectively analyzed. 2020-05-27
Case series of coronavirus (SARS-CoV-2) in a military recruit school: clinical, sanitary and logistical implications. Seven days after initial diagnosis, the index patient and the other one from the quarantine retested positive for SARS-CoV-2, although they had been completely asymptomatic for over 96 hours. 2020-05-31
Novel coronavirus disease (COVID-19) in children This review aims to summarize the current epidemics, clinical presentations, diagnosis, and treatment of COVID-19 in pediatric patients. 2020-04-22
COVID-19 outbreak control, example of ministry of health of Turkey PCR and rapid diagnostic kits are being used to analyze the samples at the central Microbiology Reference Laboratory and the authorized laboratories in several provinces. 2020-04-22
The impact of coronavirus infectious disease 19 (COVID-19) on oral health. Urgent joined research efforts regarding the SARS-COV-2 rapid tests, accurate diagnosis, especially early recognition, and effective treatment of life-threatening complications would be highly desirable for humanity and medical workforce all over the world that try to combat a current global pandemic threat. 2020-05-06
[Public health literacy in the face of the Covid-19 pandemic emergency]. This includes not only the strategy of public surveillance, but also sentinel and event-based surveillance, as it is impossible to actually identify all positive cases; b) Mitigating measures against the spread of the epidemic, such as social distancing and hygiene, washing hands, quarantine, restricting movement and using masks, among others; c) Measures to suppress transmission when the number of cases is very high, such as strict measures to stay at home; d) strengthening health services ‘capacity for medical attention and improving health services’ ability to prevent transmission, including the use of diagnostic tests; e) the development of prophylactic vaccines against Covid-19, as well as the development of therapeutic agents. 2020-04-18
Coronavirus Outbreak: Is Radiology Ready? Mass Casualty Incident Planning. A significant increase is expected in the number of imaging studies ordered for the initial diagnosis and treatment follow-up of cases of COVID-19. 2020-05-01
Epidemiological and initial clinical characteristics of patients with family aggregation of COVID-19. Epidemiological data and laboratory and imaging results were collected on the first day of admission, and analyzed based on the Diagnosis and Treatment Guideline for COVID-19 (5th edition, China). 2020-05-27
ESPEN expert statements and practical guidance for nutritional management of individuals with SARS-CoV-2 infection. Prevention, diagnosis and treatment of malnutrition should therefore be routinely included in the management of COVID-19 patients. 2020-05-31
Coronavirus-19 disease (COVID-19): A case series of early suspected cases reported and the implications towards the response to the pandemic in Zimbabwe. More COVID-19 diagnostic tests should be procured to increase the testing capacity. 2020-04-21
Epidemiology and clinical features of COVID-19: A review of current literature. Studies are rapidly published to share information regarding epidemiology, clinical and diagnostic patterns, and prognosis. 2020-05-28
Review of Artificial Intelligence Techniques in Imaging Data Acquisition, Segmentation and Diagnosis for COVID-19. Moreover, the computer-aided platforms help radiologists make clinical decisions, i.e., for disease diagnosis, tracking, and prognosis. […] In this review paper, we thus cover the entire pipeline of medical imaging and analysis techniques involved with COVID-19, including image acquisition, segmentation, diagnosis, and follow-up. 2020-05-01
[Analysis of special ehealth service for corona virus disease 2019 (COVID-19) pneumonia]. Tele-medical diagnosis and referral should be developed by local governments during COVID-19. 2020-04-22
Antibody Detection and Dynamic Characteristics in Patients with COVID-19. The gold standard for COVID-19 diagnosis was nucleic acid testing for SARS-CoV-2 by RT-PCR. […] The serodiagnostic power of the specific IgM and IgG antibodies against SARS-CoV-2 was investigated in terms of sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV) and consistency rate. […] Antibody detection may play an important role in the diagnosis of COVID-19 as complement approach for viral nucleid acid assays. 2020-04-30
COVID-19 in otolaryngologist practice: a review of current knowledge. This study provides a brief and precise review of the current knowledge regarding COVID-19, including disease transmission, clinical characteristics, diagnosis, and potential treatment. 2020-04-30
[Analysis of selective endoscopy results during the epidemic of coronavirus disease 2019 (COVID-19)]. Provided strict adherence to the epidemic prevention standards formulated by the state and professional societies, it is necessary to carry out clinical diagnosis and treatment as soon as possible. 2020-04-20
[Clinical consideration and management of coronavirus disease 2019]. How to make early diagnosis? 2020-04-21
Novel 2019 coronavirus structure, mechanism of action, antiviral drug promises and rule out against its treatment. In practice, experimental techniques can measure the time and space average properties but they cannot be captured the structural variation of the COVID-19 during the interaction of inhibitor. 2020-05-06
Development of a reverse transcription-loop-mediated isothermal amplification as a rapid early-detection method for novel SARS-CoV-2. With the recent emergence of the novel SARS-CoV-2, the availability of rapid, sensitive, and reliable diagnostic methods is essential for disease control. 2020-05-19
Different longitudinal patterns of nucleic acid and serology testing results based on disease severity of COVID-19 patients. Such information is of immediate relevance and would assist COVID-19 clinical diagnosis, prognosis and vaccine design. 2020-05-05
Chinese expert consensus on diagnosis and treatment of coagulation dysfunction in COVID-19. Therefore, the People’s Liberation Army Professional Committee of Critical Care Medicine and Chinese Society on Thrombosis and Hemostasis grouped experts from the frontline of the Wuhan epidemic to come together and develop an expert consensus on diagnosis and treatment of coagulation dysfunction associated with a severe COVID-19 infection. 2020-04-23
Severe cerebral involvement in adult-onset hemophagocytic lymphohistiocytosis. The diagnosis of hemophagocytic lymphohistiocytosis (HLH) with cerebral involvement is challenging given the rarity of HLH and its resemblance to the much more common severe sepsis. […] Timely diagnosis and treatment may be lifesaving. […] OBJECTIVE: To raise awareness about the importance of early diagnosis and treatment of HLH with neurological involvement to prevent serious complications and demise. 2020-04-23
CT imaging of the COVID-19. COVID-19 pneumonia presented with certain characteristic chest CT imaging features, which are helpful to the radiologist in the early detection and diagnosis of this emerging global health emergency. 2020-05-13
Clinical characteristics and diagnostic challenges of pediatric COVID-19: A systematic review and meta-analysis. Current diagnosis is based mainly on typical ground glass opacities on chest CT, epidemiological suspicion and contact tracing. 2020-05-13
Abdominal Pain: A Real Challenge in Novel COVID-19 Infection. In line with the current opinion of the WHO, we strongly believe that preventive measures and early diagnosis of COVID-19 are crucial to interrupt virus spread and avoid local outbreaks. 2020-04-22
Anosmia and Dysgeusia in the Absence of Other Respiratory Diseases: Should COVID-19 Infection Be Considered? In the current epidemiological context, clinical and biological work-up led to a diagnosis of COVID-19 infection. 2020-05-27
A quickly, effectively screening process of novel corona virus disease 2019 (COVID-19) in children in Shanghai, China. We report the screening and diagnosis of corona virus disease 2019 (COVID-19) in our hospital. 2020-04-23
Coronavirus Infections in Children Including COVID-19: An Overview of the Epidemiology, Clinical Features, Diagnosis, Treatment and Prevention Options in Children. In this review, we summarize epidemiologic, clinical and diagnostic findings, as well as treatment and prevention options for common circulating and novel CoVs infections in humans with a focus on infections in children. 2020-04-24
The Impact of Video-Mediated Communication on Closed Wound Assessments in Postoperative Consultations: Conversation Analytical Study. Rather, the surgeon invites the patient to assess the wound, which opens up a sequence of patient and physician assessments where diagnostic criteria such as redness or swollenness are made explicit. 2020-05-06
[The role of multimodality imaging in COVID-19 patients: from diagnosis to clinical monitoring and prognosis]. The integrated clinical, laboratory and ultrasound approach is essential for the diagnosis, monitoring and evaluation of the patient’s therapy in COVID-19 pneumonia. 2020-04-22
[Being a cardiologist at the time of SARS-COVID-19: is it time to reconsider our way of working?] If this, on one hand, results in reducing improper access to the ER and hospital, on the other hand it substantiates the risk of underestimating problems not connected to COVID-19, such as an increased delay in the diagnosis and treatment of acute myocardial infarction and other cardiovascular emergencies. 2020-04-22
Following Data as it Crosses Borders During the COVID-19 Pandemic. COVID-19 data flowing across geographic borders are extremely useful to public health professionals for many purposes such as accelerating the pharmaceutical development pipeline, and for making vital decisions about intensive care unit rooms, where to build temporary hospitals, or where to boost supplies of personal protection equipment, ventilators, or diagnostic tests. 2020-04-30
Surgical Considerations for an Awake Tracheotomy During the COVID-19 Pandemic. Preoperative testing for COVID-19, limited operating room personnel, adequate personal protective equipment, and surgical technique are factors to consider for high-risk procedures. Methods: This article presents the case of an awake tracheotomy performed for a transglottic mass causing airway obstruction. Results: With detailed planning and specific techniques, the amount of aerosolization was reduced, and the procedure was performed as safely as possible. Conclusion: This case provides a template for future aerosol-generating procedures during respiratory pandemics. 2020-05-13
Coronavirus disease 2019 during pregnancy: a systematic review of reported cases. All studies of pregnant women who received a coronavirus disease 2019 diagnosis using acid nucleic test, with reported data about pregnancy, and, in case of delivery, reported outcomes, were included. 2020-05-16
Detection and analysis of nucleic acid in various biological samples of COVID-19 patients. Real-time fluorescence quantitative reverse transcriptase polymerase chain reaction (reverse transcriptase-polymerase chain reaction,RT-PCR) and viral gene sequencing are the gold standard for the diagnosis of COVID-19. […] COVID-19 diagnostic criteria: according to China’s ⟪pneumonia diagnosis and treatment Program of novel coronavirus infection (trial version 7) ⟫, in accordance with the relevant epidemiological and clinical manifestations, nasopharyngeal swabs real-time fluorescence RT-PCR detection of 2019-nCoV nucleic acid positive, COVID-19 cases were divided into mild, ordinary, severe and severe [1]. 2020-05-13
Specific ACE2 expression in small intestinal enterocytes may cause gastrointestinal symptoms and injury after 2019-nCoV infection. The study also highlights the necessity of taking stool samples for suspected patients to help in early diagnosis and assessment of disease status. 2020-05-31
COVID-19 and the clinical hematology laboratory. In addition to its central role in the diagnosis of COVID-19 infection, the clinical laboratory provides critical information to clinicians regarding prognosis, disease course, and response to therapy. […] The purpose of this review is to 1) provide background context about the origins and course of the pandemic 2) discuss the laboratory’s role in the diagnosis of COVID-19 infection 3) summarize the current state of biomarker analysis in COVID-19 infection, with an emphasis on markers derived from the hematology laboratory 4) comment on the impact of COVID-19 on hematology laboratory safety, and 5) describe the impact the pandemic has had on organized national and international educational activities worldwide. 2020-04-20
Experiences of Patients With Rheumatic Diseases in the United States During Early Days of the COVID-19 Pandemic. Analysis compared responses by diagnosis, disease activity, and new onset of symptoms. […] Of the 7061 participants invited to participate, 530 responded, with RA as the most frequent diagnosis (61%). 2020-05-09
Imaging features and mechanisms of novel coronavirus pneumonia (COVID-19): Study Protocol Clinical Trial (SPIRIT Compliant). The COVID-19 poses significant threats to international health.Computed tomography (CT) has been an important imaging modality in assisting in the diagnosis and management of patients withCOVID-19. 2020-04-23
Variable computed tomography appearances of COVID-19. Computed tomography (CT) has been described as a diagnostic modality in the COVID-19 diagnosis and treatment plan. […] While sensitive for detecting lung parenchymal abnormalities in COVID-19 pneumonia, CT for initial diagnosis is discouraged and should be reserved for specific clinical indications. 2020-04-21
Coronavirus disease 2019 (COVID-19): two case reports from a family cluster. As two important means of examination, computed tomography (CT) and real-time reverse transcription polymerase chain reaction (RT-PCR) have always been controversial in the clinical diagnosis of COVID-19 pneumonia. […] Here, we report a family cluster case of a father and a son diagnosed as COVID-19 at our hospital, and described the clinical manifestations, laboratory results, CT changes, diagnosis and treatment strategy of these two patients. […] Focus on the value of these two methods in the diagnosis and treatment of diseases, as well as their respective deficiencies. […] For patient 1 (father), the efficacy of RT-PCR is not satisfactory either in terms of diagnosis or follow-up, which may cause misdiagnosis and delay treatment. 2020-04-21
Salvage use of tissue plasminogen activator (tPA) in the setting of acute respiratory distress syndrome (ARDS) due to COVID-19 in the USA: a Markov decision analysis. Two patient groups were simulated (50,000 patients in each group); (1) Patients received tPA immediately upon diagnosis of ARDS and (2) patients received standard therapy for ARDS. 2020-04-23
Experience and suggestion of medical practices for burns during the outbreak of COVID-19. Based on our own experience and the guidelines on the diagnosis and treatment of COVID-19 (7th Version) with other regulations and literature, we describe our experience with suggestions for medical practices for burn units during the COVID-19 outbreak. 2020-04-23
COVID-19 pneumonia with hemoptysis: Acute segmental pulmonary emboli associated with novel coronavirus infection. The overlap in the signs and symptoms of COVID-19 associated Acute Respiratory Distress Syndrome (ARDS) and COVID-19 with concurrent pulmonary embolism creates a diagnostic challenge for emergency medicine physicians in patients already at risk for renal impairment. 2020-04-26
Guillain Barre syndrome associated with COVID-19 infection: A case report. The electrodiagnostic test showed that the patient is an AMSAN variant of GBS. 2020-04-23
COVID-19 and ENT Pediatric otolaryngology during the COVID-19 pandemic. Guidelines of the French Association of Pediatric Otorhinolaryngology (AFOP) and French Society of Otorhinolaryngology (SFORL). Surgical techniques should be adapted to limit the risk of viral dissemination in the air, avoiding the use of drills, microdebriders, monopolar cautery or lasers. 2020-05-22
Identification of Potential Binders of the Main Protease 3CLpro of the COVID-19 via Structure-Based Ligand Design and Molecular Modeling. We have applied a computational strategy, using a combination of virtual screening, docking and molecular dynamics techniques, aimed at identifying possible lead compounds for the non-covalent inhibition of the main protease 3CLpro of the SARS-CoV2 Coronavirus. 2020-05-14
Chest CT Findings of Early and Progressive Phase COVID-19 Infection from a US Patient. The utility of the noncontrast CT chest in the diagnosis of COVID-19 has been controversial, but there are specific imaging findings that have been increasingly associated with this virus in the appropriate clinical context. 2020-05-31
A Review of Salivary Diagnostics and Its Potential Implication in Detection of Covid-19. Saliva has an immense potential as a diagnostic fluid and offers an edge over other biological fluids as its collection method does not require invasive procedure, economical and is useful for monitoring systemic health. […] Development of sensitive and precise salivary diagnostic tools and the formulation of defined guidelines following meticulous testing will allow salivary diagnostics to be utilised as chair side tests for various oral and systemic diseases in the near future. […] Rapid and accurate diagnosis of Covid-19 is crucial in controlling the outbreak in the community and in hospitals. […] Nasopharyngeal and oropharyngeal swabs are the recommended specimen types for Covid-19 diagnostic testing. […] Salivary diagnostics is a dynamic field that is being incorporated as part of disease diagnosis, clinical monitoring of systemic health and to make significant clinical decisions for patient care. […] More research is required to analyze the potential diagnostic of Covid-19 in saliva to develop rapid chair side tests for the detection of Covid-19 and it is also pivotal to improve and develop successful strategies for prevention, especially for dentists and healthcare professionals who are involved in performing aerosol-generating procedures. 2020-04-23
Recent apprise on coronavirus and its terrible insinuations. There are two diagnostic tests for coronavirus infection i.e. molecular test and serology test. 2020-04-23
A “One-Health” approach for diagnosis and molecular characterization of SARS-CoV-2 in Italy. In this perspective, to support the National Health Care System and to minimize the impact of this rapidly spreading virus, the Italian Ministry of Health involved the Istituti Zooprofilattici Sperimentali (IZSs), Veterinary Public Health Institutes, in the diagnosis of SARS-CoV-2 by testing human samples. 2020-05-30
Medically unexplained symptoms in the times of Covid-19 pandemic: a case-report. Based on his medical history and current presentation, he received a diagnosis of SSD. 2020-05-20
Recommendation of a practical guideline for safe tracheostomy during the COVID-19 pandemic. Both percutaneous and open techniques can be performed safely with careful modifications to technique and appropriate enhanced personal protective equipment. 2020-04-30
COVID-19 patients and the radiology department - advice from the European Society of Radiology (ESR) and the European Society of Thoracic Imaging (ESTI). This document from the European Society of Radiology (ESR) and the European Society of Thoracic Imaging (ESTI) aims to present the main imaging features, and the role of CT scan in the early diagnosis of COVID-19, describing, in particular, the typical findings which make it possible to identify the disease and distinguish it from bacterial causes of infection, and to define which category of patients may benefit from CT imaging. 2020-04-29
Bariatric Surgical Practice During the Initial Phase of COVID-19 Outbreak. Correct diagnosis and management in the postoperative setting would be challenging. 2020-04-23
Case Report: The First Case of Novel Coronavirus Disease (COVID-19) in Bhutan. His atypical presentation led to a delay in diagnosis, but ultimately he was isolated and tested. […] On confirming the diagnosis of COVID-19, the patient was isolated in a separate hospital with a dedicated medical care team. 2020-04-21
Case Report: The Importance of Novel Coronavirus Disease (COVID-19) and Coinfection with Other Respiratory Pathogens in the Current Pandemic. The initial testing strategy resulted in delays in both diagnosis and implementation of appropriate precautions. 2020-04-21
Fast Identification of Possible Drug Treatment of Coronavirus Disease-19 (COVID-19) through Computational Drug Repurposing Study. It is very efficient to apply computer-aided drug design techniques to quickly identify promising drug repurposing candidates, especially after the detailed 3D structures of key viral proteins are resolved. 2020-05-07
Suppressed T cell-mediated immunity in patients with COVID-19: A clinical retrospective study in Wuhan, China. The decreased levels of T lymphocyte subsets reported in our study were similar with SARS but not common among other virus infection, which may be possible biomarkers for early diagnosis of COVID-19. 2020-04-26
What do we know about the SARS-CoV-2 coronavirus in the environment? Also, the evaluation of current treatments for wastewater and sewage sludge, as well as the eventual development of new specific techniques, based on sorption, nanotechnology, etc., would be of great interest for controlling the environmental dissemination of these viruses in the current and eventual future outbreaks. 2020-05-29
Geographical Accessibility to Glucose-6-Phosphate Dioxygenase Deficiency Point-of-Care Testing for Antenatal Care in Ghana. To enable the World Health Organization include appropriate G6PD POC diagnostic tests in its list of essential in-vitro diagnostics for use in resource-limited settings, we recommend a wider evaluation of available POC diagnostic tests for G6PD deficiency, particularly in malaria-endemic countries. 2020-05-29
Novel Coronavirus: Current Understanding of Clinical Features, Diagnosis, Pathogenesis, and Treatment Options. The purpose of this review is to provide a comprehensive update on the pathogenesis, clinical aspects, diagnosis, challenges and treatment of SARS-CoV-2 infections. 2020-05-29
[Explore the Optimal Resolvent of Medical Needs and Mental Health for Patients with Lung Cancer during Epidemic Novel Coronavirus Pneumonia]. The aims were to investigate medical needs of lung cancer patients and their mental health status during the epidemic periods, so as to provide rational recommendations for subsequent diagnosis and treatment. 2020-05-16
Drugs supply and pharmaceutical care management practices at a designated hospital during the COVID-19 epidemic. According to COVID-19 prevention and control policy and requirements, combined with series of diagnosis and treatment plans, pharmacists in the first provincial-level COVID-19 diagnosis and treatment unit in Jilin Province in Northeast China have established the management practices of drug supply and pharmaceutical care from four aspects: personnel, drugs supply management, off-label drug use management and pharmaceutical care. 2020-04-24
Saliva as a non-invasive specimen for detection of SARS-CoV-2. Diagnostic testing for COVID-19 is central to controlling the global pandemic. 2020-04-22
Detection of coronaviruses in Pteropus & Rousettus species of bats from different States of India. This would help in the development of diagnostic assays for novel viruses with outbreak potential and be useful in disease interventions. 2020-05-06
Extracorporeal Membrane Oxygenation in the Treatment of Severe Pulmonary and Cardiac Compromise in COVID-19: Experience with 32 patients. Data captured included patient characteristics, pre-COVID-19 risk factors and comorbidities, confirmation of COVID-19 diagnosis, features of ECMO support, specific medications utilized to treat COVID-19, and short-term outcomes through hospital discharge. 2020-05-15
The suspected SARS-Cov-2 infection in a Charcot-Marie-Tooth patient undergoing postsurgical rehabilitation: the value of telerehabilitation for evaluation and continuing treatment. The diagnosis was established through a remote interaction with the patient after early discharge from outpatient therapy due to upcoming traveling restrictions. 2020-05-26
Potential for Lung Recruitment and Ventilation-Perfusion Mismatch in Patients With the Acute Respiratory Distress Syndrome From Coronavirus Disease 2019. ICU of a university-affiliated hospital from northern Italy dedicated to care of patients with confirmed diagnosis of coronavirus disease 2019. […] Ten intubated patients with acute respiratory distress syndrome and confirmed diagnosis of coronavirus disease 2019. 2020-04-30
Understanding SARS-CoV-2: Genetic Diversity, Transmission and Cure in Human. The emerging trends in SARS-CoV-2 genome data show specific mutation and genetic diversity, which could provide the basis to develop a cocktail of vaccine and may also be used to develop the region-specific diagnostic tool, thus decreasing the chances of testing failures in fields. 2020-04-24
The clinical data from 19 critically ill patients with coronavirus disease 2019: a single-centered, retrospective, observational study. The objectives of this study were to analyze the clinical features of coronavirus disease 2019 (COVID-19) and evaluate the diagnosis and treatment. 2020-04-24
Epidemiological and clinical characteristics of 26 asymptomatic SARS-CoV-2 carriers. The median period from contact to diagnosis and the last positive nucleic acid test was 19 (8-24 days) and 21.5 days (10-36 days), respectively. […] The median period from diagnosis to negative nucleic acid test was significantly different between patients with normal or atypical chest computed tomography (CT) findings (n=16, 61.5%; 7.5 days [2-20 days]) and patients with typical ground-glass or patchy opacities on CT(n=10, 38.5%; 12.5 days[8-22 days]; P<0.01). 2020-04-30
Sonographic signs and patterns of COVID-19 pneumonia. The sonographic signs are non-specific when considered alone, but observation of some aspects of vertical artifacts can enhance the diagnostic power of the ultrasound examination. 2020-04-24
[It’s world war at CoViD-19. The first battle on the front of the viral invasion against the exitus for interstitial pneumonia was decisive.] An early diagnosis associated with an appropriate therapeutic action in the initial stages of the disease can reduce the progression of CoViD-19 towards interstitial pneumonia, thus interfering with the number of transfers to intensive care and lethality of the pandemic in progress. 2020-04-24
Anosmia as a prominent symptom of COVID-19 infection. Due to the lack of current effective treatment and vaccine for COVID-19, screening, rapid diagnosis and isolation of the patients are essential (1, 2). 2020-04-22
Evaluation of the auxiliary diagnostic value of antibody assays for the detection of novel coronavirus (SARS-CoV-2). The goal of this study was to assess the diagnostic values of different methods of detecting and estimating the SARS-CoV-2 infection, and the auxiliary diagnostic potential of antibody assays. 2020-04-22
Logic in the time of coronavirus. Emerging infectious diseases by their nature, pose new challenges to the diagnostic-treatment-control nexus, and push our concepts of causality beyond the limits of the conventional Koch-Henle approach to aetiology. 2020-05-29
Changes in testing rates could mask the novel coronavirus disease (COVID-19) growth rate. Using daily time series of COVID-19 incidence, we illustrate how epidemic curves of reported cases may not always reflect the true epidemic growth rate due to changes in testing rates, which could be influenced by limited diagnostic testing capacity during the early epidemic phase. 2020-05-20
Characteristic CT findings distinguishing 2019 novel coronavirus disease (COVID-19) from influenza pneumonia. • CT can play an early warning role in the diagnosis of COVID-19 in the case of no epidemic exposure. […] • CT could be used for the differential diagnosis of influenza and COVID-19 with satisfactory accuracy. 2020-05-01
SAGES and EAES recommendations for minimally invasive surgery during COVID-19 pandemic. The ultimate decision on the approach should be made after considering the proven benefits of laparoscopic techniques versus the potential theoretical risks of aerosolization. 2020-05-14
Medical genetics education in the midst of the COVID-19 pandemic: Shared resources. Not only will this allow us to continue our strong history of education, it will enhance our strong commitment to using modern educational techniques and tools to address the genetics workforce issues that have defined the recent past. 2020-05-29
Rapid and Sensitive Detection of anti-SARS-CoV-2 IgG, Using Lanthanide-Doped Nanoparticles-Based Lateral Flow Immunoassay. Simple and rapid immunodiagnostic methods are urgently needed to identify positive cases. […] The results of the validation experiment met the requirements for clinical diagnostic reagents. 2020-05-21
Diagnosis, Prevention, and Treatment of Thromboembolic Complications in COVID-19: Report of the National Institute for Public Health of the Netherlands. This report summarizes evidence for thromboembolic disease, potential diagnostic and preventive actions as well as recommendations for patients with COVID-19 infection. 2020-04-23
COVID-19 pneumonia in a kidney transplant recipient successfully treated with tocilizumab and hydroxychloroquine. We describe the case of a 61-year-old kidney transplant recipient with several comorbidities who was hospitalized and later received a diagnosis of COVID-19 pneumonia; the infection was successfully managed with the use of hydroxychloroquine and a single administration of tocilizumab, after immunosuppression reduction; the patient did not require mechanical ventilation. 2020-05-13
Diagnostic consideration and bedside estimation of the prognosis in COVID-19 patients Here below, we focus mainly on the diagnostic issues of COVID-19 and on the estimation of the prognosis. […] We also focus on the proper method of microbiological sampling and the relevant informations regarding diagnostic tests like the gold standard real-time reverse transcriptase polymerase chain reaction (RT-PCR) for SARS-CoV-2. 2020-04-27
Importance of the imaging techniques in the management of COVID-19-infected patients Thus, imaging techniques are situated in the frontline to aim the diagnostic decision-making, to follow up the progress and to evaluate the possible complications. 2020-04-27
Do Not Forget Afghanistan in Times of COVID-19: Telemedicine and the Internet of Things to Strengthen Planetary Health Systems. There is a need for medical and scientific expertise to clinically and sociologically contextualize and interpret diagnostic tests as well as drugs and vaccines that will be deployed in the coming months as part of the planetary collective response to the COVID-19 pandemic. 2020-04-23
Radiological Society of North America Expert Consensus Statement on Reporting Chest CT Findings Related to COVID-19. Endorsed by the Society of Thoracic Radiology, the American College of Radiology, and RSNA. We also anticipate that some patients will have incidentally detected findings that could be attributable to COVID-19 pneumonia, requiring radiologists to decide whether or not to mention COVID-19 specifically as a differential diagnostic possibility. 2020-05-30
Personal Safety during the COVID-19 Pandemic: Realities and Perspectives of Healthcare Workers in Latin America. Healthcare workers exposed to coronavirus (COVID-19) may not have adequate access to personal protective equipment (PPE), safety procedures, and diagnostic protocols. […] The vast majority (n = 707; 75.5%) had access to personal safety policies and procedures, and 699 (74.7%) participants had access to diagnostic algorithms. 2020-04-29
Can Nanotechnology and Materials Science Help the Fight against SARS-CoV-2? While great resources are understandably being dedicated to treatment and diagnosis, more efforts could be dedicated to limit the virus spread. 2020-05-23
Early chest computed tomography to diagnose COVID-19 from suspected patients: A multicenter retrospective study. The purpose of this study was to distinguish the imaging features of COVID-19 from those of other infectious pulmonary diseases and evaluate the diagnostic value of chest CT for suspected COVID-19 patients. […] The combinations with GGOs could be useful in the identification and differential diagnosis of COVID-19, alerting clinicians to isolate patients for prompt treatment and repeat RT-PCR tests until the end of incubation. 2020-04-27
Point of care and intensive care lung ultrasound: A reference guide for practitioners during COVID-19. Ultrasound, although not used in the diagnosis of COVID-19 may be utilised by practitioners at the point of care (POC) or on the intensive care units (ITUs) where rapid assessment of the lung condition may be required. […] Ultrasound is being used in Italy and China to help review lung condition during the COVID-19 outbreak however not strictly as a diagnostic tool as Computed Tomography (CT) of the chest and chest radiographs are currently gold standard. […] However it should not be used as a diagnostic tool for COVID-19 due to low specificity in relation to the virus. 2020-04-27
Comparison of Abbott ID Now and Abbott m2000 methods for the detection of SARS-CoV-2 from nasopharyngeal and nasal swabs from symptomatic patients. Scarborough, ME) is a rapid diagnostic test that can be performed in a point of care setting equivalent to CLIA waived testing. 2020-04-24
SARS-COV-2 infection (coronavirus disease 2019) for the gastrointestinal consultant. Many of the medications used for treatment of COVID-19 can also be associated with GI symptoms or liver injury and can be included in the differential diagnosis in these patients. […] Although the diagnosis of the infection is currently based on RNA analysis in respiratory samples, the available literature on fecal shedding of this virus suggests that fecal RNA testing might prove to be a useful diagnostic test. 2020-04-27
Clinical Pathway for Early Diagnosis of COVID-19: Updates from Experience to Evidence-Based Practice. Diagnostic criteria and the identification of persons under investigation have evolved as more data has emerged. […] However, the approach to diagnosis is still very variable from region to region, country to country, and even among different hospitals in the same city. […] The importance of a clinical pathway to implement the most effective and relevant diagnostic strategy is of critical importance to establish the control of this virus that is responsible for more and more deaths each day. 2020-05-08
Study of SARS-CoV-2 in semen and urine samples of a volunteer with positive naso-pharyngeal swab. Although this should be interpreted cautiously, it may be possible that either the viral clearance kinetics in these matrices matches the progressive clinical recovery of the patient or that the virus was never present in these fluids at the time of the laboratory diagnosis. 2020-05-07
Application of a portable instrument for rapid and reliable detection of SARS-CoV-2 infection in any environment. Indeed, there is urgent need to develop and deploy robust diagnostic methodologies not only to use in health laboratory environments but also directly in places where humans circulate and spread the virus such as airports, trains, boats, and any public aggregation places. […] The success of a reliable and sensitive asymptomatic diagnosis relies on the identification and measurement of informative biomarkers from human host and virus in a rapid, sensitive, and inexpensive manner. 2020-05-27
[An analysis of global research on SARS-CoV-2]. All articles were categorized into epidemiology, clinical diagnosis and treatment, basic research, pregnant women and children, mental health, epidemic prevention & control, and others. 2020-04-27
[Spike protein in the detection and treatment of novel coronavirus]. In this review we introduce these research works related to spike proteins, hoping it will provide reasonable ideas for the control of the current pandemic, as well as for the diagnosis and treatment of COVID-19. 2020-04-27
Novel Coronavirus Disease (COVID-19) Serosurveillance May Facilitate Return-to-Work Decisions. Reverse transcriptase-polymerase chain reaction testing, our primary diagnostic tool to date, has sensitivity and timing concerns, owing to sampling/handling errors, as well as a complex virus-host interaction. 2020-05-06
Role of Telehealth in the Management of COVID-19: Lessons Learned from Previous SARS, MERS, and Ebola Outbreaks. Concerns about the prevention and management of COVID-19 are on the rise, as it is crucial in contagious epidemics that travel and transfer of the patients be minimal for diagnosis, treatment, and follow-ups. 2020-04-24
SARS-CoV-2 causing pneumonia-associated respiratory disorder (COVID-19): diagnostic and proposed therapeutic options. In this crisis, a collective pool of knowledge about the advancement of clinical diagnostic and management for COVID-19 is a prerequisite. […] Here, we summarize all the available updates on the multidisciplinary approaches for the advancement of diagnosis and proposed therapeutic strategies for COVID-19. […] Advances in various diagnostic approaches, such as the use of real-time polymerase chain reaction (RT-PCR), chest radiography, and computed tomography (CT) imaging; and other modern diagnostic methods, for this infection have been highlighted. […] Collectively, the review provides an overview of the SARS-CoV-2 infection outbreak along with the recent advancements and strategies for diagnosis and therapy of COVID-19. 2020-04-30
Eculizumab treatment in patients with COVID-19: preliminary results from real life ASL Napoli 2 Nord experience. This is a case series of patients with a confirmed diagnosis of SARS-CoV2 infection and severe pneumonia or ARDS who were treated with up to 4 infusions of eculizumab as an off-label agent. 2020-04-29
Transition to a virtual multidisciplinary tumor board during the COVID-19 pandemic: University of Pittsburgh experience. Multidisciplinary conferences (MDC) are an important component of head and neck oncologic care including diagnosis, treatment, and survivorship. 2020-05-29
Dental Care and Oral Health under the Clouds of COVID-19. Dental professionals may play an important role in early identification and diagnosis of patients with COVID-19. 2020-04-24
Leveraging open hardware to alleviate the burden of COVID-19 on global health systems. With the current rapid spread of COVID-19, global health systems are increasingly overburdened by the sheer number of people that need diagnosis, isolation and treatment. 2020-04-29
Diagnostic accuracy of an automated chemiluminescent immunoassay for anti-SARS-CoV-2 IgM and IgG antibodies: an Italian experience. Though molecular diagnostic tests are the gold standard for COVID-19, serological testing is emerging as a potential surveillance tool, in addition to its complementary role in COVID-19 diagnostics. 2020-05-11
Characteristics of patients with coronavirus disease (COVID-19) confirmed using an IgM-IgG antibody test. Nucleic acid testing is the standard method for the diagnosis of viral infections. […] The IgM-IgG test is an accurate and sensitive diagnostic method. […] A combination of nucleic acid and IgM-IgG testing is a more sensitive and accurate approach for diagnosis and early treatment of COVID-19. 2020-05-08
Asymptomatic COVID-19 infection in late pregnancy indicated no vertical transmission. Diagnosis of late pregnancy with asymptomatic COVID-19 infection was made. 2020-04-30
Cutaneous manifestations in COVID-19: the experiences of Barcelona and Rome. The diagnosis is made employing quantitative reverse transcriptase polymerase chain reaction to identify the viral nucleic acid in respiratory specimens or blood samples. 2020-04-24
Earliest cases of coronavirus disease 2019 (COVID-19) identified in solid organ transplant recipients in the United States. We describe each patient’s medical history including transplantation history, their clinical presentation and workup, and their course from diagnosis to either hospital discharge or to improvement in symptoms. 2020-05-08
The Architecture of SARS-CoV-2 Transcriptome. Utilizing two complementary sequencing techniques, we present a high-resolution map of the SARS-CoV-2 transcriptome and epitranscriptome. 2020-05-19
COVID-19: a meta-analysis of diagnostic test accuracy of commercial assays registered in Brazil. We searched at the Brazilian Health Regulatory Agency (ANVISA) online platform to describe the pooled sensitivity (Se), specificity (Sp), diagnostic odds ratio (DOR) and summary receiver operating characteristic curves (SROC) for detection of IgM/IgG antibodies and for tests using naso/oropharyngeal swabs in the random-effects models. […] Pooled diagnostic accuracy measures [95%CI] were: (i) for IgM antibodies Se=82% [76-87]; Sp=97% [96-98]; DOR=168 [92-305] and SROC=0.98 [0.96-0.99]; (ii) for IgG antibodies Se=97% [90-99]; Sp=98% [97-99]; DOR=1994 [385-10334] and SROC=0.99 [0.98-1.00]; and (iii) for detection of SARS-CoV-2 by antigen or molecular assays in naso/oropharyngeal swabs Se=97% [85-99]; Sp=99% [77-100]; DOR=2649 [30-233056] and SROC=0.99 [0.98-1.00]. […] Future studies addressing the diagnostic performance of tests for COVID-19 in the Brazilian population are urgently needed. 2020-04-28
Connecting clusters of COVID-19: an epidemiological and serological investigation. Diagnosis for acute disease was confirmed with RT-PCR testing. 2020-04-27
Effect of changing case definitions for COVID-19 on the epidemic curve and transmission parameters in mainland China: a modelling study. When a new infectious disease emerges, appropriate case definitions are important for clinical diagnosis and for public health surveillance. 2020-05-13
Successful recovery of COVID-19 pneumonia in a patient from Colombia after receiving chloroquine and clarithromycin. His chest computed tomography was performed and showed bilateral multifocal ground-glass opacities with consolidation, which suggested viral pneumonia as a differential diagnosis. 2020-04-28
Anticipating and Mitigating the Impact of the COVID-19 Pandemic on Alzheimer’s Disease and Related Dementias. We discuss and propose mitigation strategies for: the risk of COVID-19 infection and its associated morbidity and mortality for individuals with ADRD; the impact of COVID-19 on the diagnosis and clinical management of ADRD; consequences of societal responses to COVID-19 in different ADRD care settings; the effect of COVID-19 on caregivers and physicians of individuals with ADRD; mental hygiene, trauma, and stigma in the time of COVID-19; and the potential impact of COVID-19 on ADRD research. 2020-04-28
Clinical Evaluation of Three Sample-To-Answer Platforms for the Detection of SARS-CoV-2. As part of the worldwide response, many molecular diagnostic platforms have been granted Emergency Use Authorization (EUA) by the Food and Drug Administration (FDA) to identify SARS-CoV-2 positive patients. […] Our objective was to evaluate three sample-to-answer molecular diagnostic platforms (Cepheid Xpert® Xpress SARS-CoV-2 [Xpert Xpress], Abbott ID NOW™ COVID-19 [ID NOW], GenMark ePlex® SARS-CoV-2 Test [ePlex]) to determine analytical sensitivity, clinical performance, and workflow for the detection of SARS-CoV-2 in nasopharyngeal swabs from 108 symptomatic patients. 2020-04-25
Neutralization of SARS-CoV-2 spike pseudotyped virus by recombinant ACE2-Ig. As these fusion proteins exhibit cross-reactivity against coronaviruses, they have potential applications in the diagnosis, prophylaxis, and treatment of SARS-CoV-2. 2020-04-28
The genetic sequence, origin, and diagnosis of SARS-CoV-2. In this review, we introduced current diagnostic methods and criteria for the SARS-CoV-2 in China and discuss the advantages and limitations of the current diagnostic methods, including chest imaging and laboratory detection. 2020-05-01
Updated diagnosis, treatment and prevention of COVID-19 in children: experts’ consensus statement (condensed version of the second edition). In the early February, 2020, we called up an experts’ committee with more than 30 Chinese experts from 11 national medical academic organizations to formulate the first edition of consensus statement on diagnosis, treatment and prevention of coronavirus disease 2019 (COVID-19) in children, which has been published in this journal. […] With accumulated experiences in the diagnosis and treatment of COVID-19 in children, we have updated the consensus statement and released the second edition recently. […] The current version in English is a condensed version of the second edition of consensus statement on diagnosis, treatment and prevention of COVID-19 in children. […] In the current version, diagnosis and treatement criteria have been optimized, and early identification of severe and critical cases is highlighted. […] This version of experts consensus will be valuable for better prevention, diagnosis and treatment of COVID-19 in children worldwide. 2020-05-01
Point-of-Care Lung Ultrasound Findings in Patients with Novel Coronavirus Disease (COVID-19) Pneumonia. Further studies are needed to evaluate the utility of lung ultrasound in the diagnosis and management of COVID-19. 2020-05-06
RT-LAMP for rapid diagnosis of coronavirus SARS-CoV-2. To curb the spreading of the virus, WHO urgently demanded an extension of screening and testing; thus, a rapid and simple diagnostic method is needed. 2020-04-25
Presepsin in risk stratification of SARS-CoV-2 patients. Soluble cluster of differentiation (CD)14 subtype (sCD14-ST also termed presepsin PSP) is a regulatory factor that modulates immune responses by interacting with T and B cells, useful for early diagnosis, prognosis and risk stratification prediction. 2020-05-18
Practical Considerations for the Diagnosis and Treatment of Fibrotic Interstitial Lung Disease During the COVID-19 Pandemic. Major issues for patients with ILD will include restricted access to key components of the diagnostic process, new uncertainties in the use of common ILD pharmacotherapies, limited ability to monitor both disease severity and the presence of medication adverse effects, and significantly curtailed research activities. […] The purpose of this review is to summarize how COVID-19 has impacted key components of the diagnosis and management of fibrotic ILD as well as to provide strategies to mitigate these challenges. 2020-05-10
Recommendations for triage, prioritization and treatment of breast cancer patients during the COVID-19 pandemic. In this manuscript we provide guidance to prepare for the impact of COVID-19 pandemic on breast cancer patients and advise on how to triage, prioritize and organize diagnostic procedures, surgical, radiation and medical treatments. 2020-05-29
[Management of a radiotherapy center during the COVID-19 outbreak: The experience of the Mulhouse hospital centre (France)]. The ability to perform diagnostic tests in all suspect patients would also allow us to refine our procedures. 2020-04-28
Highly sensitive detection of SARS-CoV-2 RNA by multiplex rRT-PCR for molecular diagnosis of COVID-19 by clinical laboratories. The detection of SARS-CoV-2 RNA by real-time reverse transcription-polymerase chain reaction (rRT-PCR) is used to confirm the clinical diagnosis of COVID-19 by molecular diagnostic laboratories. 2020-05-18
Is returning to work during the COVID-19 pandemic stressful? A study on immediate mental health status and psychoneuroimmunity prevention measures of Chinese workforce. From 673 valid questionnaires, we found that 10.8% of respondents met the diagnosis of post-traumatic stress disorder (PTSD) after returning to work. 2020-04-29
Imaging of coronavirus disease 2019: A Chinese expert consensus statement. Early detection, isolation, diagnosis, and treatment are the most effective means of prevention and control. […] The current gold standard for the diagnosis of COVID-19 is the detection of coronavirus nucleic acids, but imaging has an important role in the detection of lung lesions, stratification, evaluation of treatment strategies, and differentiation of mixed infections. 2020-05-15
The Coronavirus Pandemic: What Does the Evidence Show? Real-time reverse-transcription polymerase chain reaction (rRT-PCR) screening is considered as the standard laboratory test for the diagnosis of COVID-19. 2020-04-28
COVID-19: an update on diagnostic and therapeutic approaches. Currently, various diagnostic kits to test for COVID-19 are available, and repurposing therapeutics for COVID-19 has shown to be clinically effective. 2020-04-29
SEPAR-AEER Consensus Recommendations on the Usefulness of the Thoracic Ultrasound in the Management of the Patient with Suspected or Confirmed Infection with COVID-19. The great pulmonary affectation produced by the COVID-19 infection, requires a fast diagnostic tool that complements the diagnostic test by PCR and which is also useful in evaluating the progression of lung lesions. […] Since most of these are peripheral, in this consensus document we propose the use of thoracic ultrasound for early diagnosis and for the daily evaluation of the progression of lung lesions by a single explorer without the need to use the chest CT. 2020-04-29
COVID-19 outbreak: An elusive enemy. Since containment of the outbreak may have partially failed due to asymptomatic transmission, it is imperative to accelerate the development of rapid point-of-care diagnostic tests, vaccines, and therapeutics for the COVID-19 epidemic. 2020-04-30
SARS-CoV-2 (COVID-19) and intravascular volume management strategies in the critically ill. While knowledge regarding epidemiologic features and diagnostic tools of coronavirus disease 2019 (COVID-19) is rapidly evolving, uncertainties surrounding various aspects of its optimal management strategies persist. 2020-05-06
Brief Review on COVID-19: The 2020 Pandemic Caused by SARS-CoV-2. In this study, we will provide a brief review of viral origin, identification, symptoms, transmission, diagnosis, and potential treatment strategies for the newly identified SARS-CoV-2 strain. 2020-04-30
Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2): An Update. Some preventive strategies of the disease include blocking the routes of transmission of the infections, disinfection of instruments used during medical case handling, using personal protective equipment, proper and early diagnosis of the disease, avoiding contact with the sick patients, and quarantine of the infected/exposed people. 2020-04-30
Corona Virus Disease 2019 (COVID-19) Presenting as Acute ST Elevation Myocardial Infarction. We need more research in Covid-19 patients with cardiovascular involvement for early diagnosis, prevention of exposure to health care workers and effective treatment. 2020-04-30
Atypical presentation of SARS-CoV-2 infection: A case report. Careful acquisition of an epidemiological history is necessary to make a correct diagnosis and strategize a treatment plan. 2020-04-30
Classification of COVID-19 patients from chest CT images using multi-objective differential evolution-based convolutional neural networks. Extensive experiments are performed by considering the proposed and the competitive machine learning techniques on the chest CT images. 2020-05-07
Rational Use of Tocilizumab in the Treatment of Novel Coronavirus Pneumonia. In this paper, we will elaborate the role of cytokine storm in COVID-19, the mechanism of tocilizumab on cytokine storm and the key points of pharmaceutical care based on the actual clinical application for COVID-19 in our hospital, the latest research reports, clinical trial progress of tocilizumab, drug instruction from the US FDA, and “Diagnosis and Treatment Plan of Novel Coronavirus Pneumonia (seventh trial edition)” in China, so as to provide reference for the treatment of COVID-19. 2020-05-28
Clinical role of lung ultrasound for the diagnosis and monitoring of COVID-19 pneumonia in pregnant women. Although chest Computer Tomography (CT) represents the gold standard to assess lung involvement, with a specificity even superior to the nasal/pharyngeal swab for diagnosis, lung ultrasound examination can be a valid alternative to CT scan, with some advantages, particularly desirable for pregnant women. 2020-04-27
COVID-19 in Children: Clinical Approach and Management. Diagnosis can be confirmed by Reverse transcriptase - Polymerase chain reaction (RT-PCR) on respiratory specimen (commonly nasopharyngeal and oropharyngeal swab). […] Rapid progress is being made to develop rapid diagnostic tests, which will help ramp up the capacity to test and also reduce the time to getting test results. 2020-05-19
CO-RADS - A categorical CT assessment scheme for patients with suspected COVID-19: definition and evaluation. The resulting area under the receiver operating characteristics curve (AUC) was compared to results from RT-PCR and clinical diagnosis of COVID-19. […] The average AUC was 0.91 (95% CI 0.85-0.97) for predicting RT-PCR outcome and 0.95 (95% CI 0.91-0.99) for clinical diagnosis. 2020-04-27
Epidemiological characteristics and incubation period of 7,015 confirmed cases with Coronavirus Disease 2019 outside Hubei Province in China. Incubation period and interval times were calculated using dates of the following events: contact with an infected person, onset, first visit and diagnosis. […] In addition, the lengths of the intervals between onset and diagnosis, onset and first visit, and first visit and diagnosis decreased over time. 2020-05-06
Patient blood management during the COVID-19 pandemic: a narrative review. We discuss how preventative and control measures implemented during the COVID-19 crisis could affect the prevalence of anaemia, and highlight issues regarding the diagnosis and treatment of anaemia in patients requiring elective or emergency surgery. 2020-05-06
Abnormalities of peripheral blood system in patients with COVID-19 in Wenzhou, China. In severe ICU group, patients have the lowest count of lymphocytes, but the highest neutrophil count and NLR among the above three groups (all P values < 0.05); NLR and MLR indicators were combined for diagnostic efficacy analysis of severe COVID-19, and its area under the curve reached 0.925. 2020-05-18
Addressing the Impact of the Coronavirus Disease 2019 (COVID-19) Pandemic on Hematopoietic Cell Transplantation: Learning Networks as a Means for Sharing Best Practices. This perspective paper reviews the following: current COVID-19 epidemiology, diagnosis, and potential therapies; care considerations unique to HCT recipients; and the concept of a learning network to assimilate emerging guidelines and best practices and to optimize patient outcomes through facilitating shared learning and experience across transplantation centers. 2020-05-07
Estimating instant case fatality rate of COVID-19 in China. The estimated diagnosis dates of deaths and cured cases were calculated based on median cure time or median death time of individual cases. […] Afterward, instant fatality rate was calculated according to the number of deaths and cured cases on the same estimated diagnosis date. 2020-04-29
Coronavirus Disease 2019 in a Hemodialysis Patient. The difficulties in diagnosis, infection control, and treatment of COVID-19 in maintenance HD patients are discussed in this report. 2020-04-27
[Epidemic characteristics and trend analysis of the COVID-19 in Hubei province]. Objective: By describing and analyzing the epidemic characteristics and trends of the attack rate, the crude mortality and relevant indexes in Hubei province during the pandemic of COVID-19 to provide comprehensive evaluations of the epidemic trends and the effects of intervention measures. Methods: Based on the case data reported in Hubei province during the COVID-19 epidemic, combined with the important time of major interventions and event, the cumulative attack rate, the sequential increase rate of new cases, baseline increase rate of new cases, the observation- confirmed case conversion rate, the cumulative crude mortality, the daily severe case rate, and the ratio of death to severe were used to describe and analyze the epidemic characteristics in different phases of the COVID-19 epidemic. Results: The epidemic experienced an outbreak phase from January 10 to February 3 with large amount of case reported, a peak phase from February 4 to February 19 with continuous increasing number of new cases and deaths, a platform phase from February 20 to March 3 with balanced diagnosis and treatment number, and a descending phase from March 4 to March 18 with decreased diagnosis and increased treatment number. 2020-04-28
[Preliminary clinical study of direct renin inhibitor aliskiren in the treatment of severe COVID-19 patients with hypertension]. The previous diagnosis of hypertension was clear. 2020-04-28
The Use of Digital Health in the Detection and Management of COVID-19. This commentary explores the potential of implementing digital technologies that can be used at different stages of the COVID-19 outbreak, including data-driven disease surveillance, screening, triage, diagnosis, and monitoring. 2020-04-30
Putative Inhibitors of SARS-CoV-2 Main Protease from A Library of Marine Natural Products: A Virtual Screening and Molecular Modeling Study. We identified potent Mpr inhibitors employing computational techniques that entail the screening of a Marine Natural Product (MNP) library. […] Molecular dynamics and re-docking further confirmed the results obtained by structure-based techniques and allowed this study to highlight some crucial aspects. 2020-04-29
Laryngeal Evaluation during the COVID-19 Pandemic: Transcervical Laryngeal Ultrasonography. When possible, alternative diagnostic and treatment strategies should be pursued. 2020-04-28
COVID-19 Anosmia Reporting Tool: Initial Findings. We analyzed the first 237 entries, which revealed that anosmia was noted in 73% of patients prior to COVID-19 diagnosis and was the initial symptom in 26.6%. 2020-04-28
Management of the SARS-CoV-2 (COVID-19) coronavirus epidemic in hemodialysis units. They are recommendations in continuous review and can be modified if the epidemiological situation, the diagnostic and therapeutic options so require. 2020-04-30
Coronavirus disease 2019 (COVID-19): A literature review. In this literature review, the causative agent, pathogenesis and immune responses, epidemiology, diagnosis, treatment and management of the disease, control and preventions strategies are all reviewed. 2020-05-05
Management of patients with suspected or confirmed COVID-19, in the radiology department. In consideration of the crucial role of diagnostic testing during COVID-19, the aim of this technical note was to provide a complete synthesis of approaches implemented for the management of suspected or confirmed COVID-19 patients. 2020-04-30
COVID-19 patients presenting with afebrile acute abdominal pain. With the surge in COVID-19 cases worldwide, the medical community should be aware of atypical clinical presentations to help with correct diagnosis, to take the proper measures to place the patient in isolation and to avoid healthcare professionals being infected by coronavirus (SARS-CoV-2). […] In our case series, CT scan findings helped us to suspect the correct diagnosis, which was subsequently confirmed with COVID-19 RT-PCR tests. 2020-04-28
Comparison of Four Molecular In Vitro Diagnostic Assays for the Detection of SARS-CoV-2 in Nasopharyngeal Specimens. In the present study, we have evaluated the analytical sensitivity and clinical performance of four SARS-CoV-2 molecular diagnostic assays granted Emergency Use Authorization by the FDA using nasopharyngeal swabs from symptomatic patients: the New York SARS-CoV-2 Real-time Reverse Transcriptase (RT)-PCR Diagnostic Panel (Modified CDC), the Simplexa COVID-19 Direct (Diasorin Molecular), GenMark ePlex SARS-CoV-2 assay (GenMark) and the Hologic Panther Fusion® SARS-CoV-2 assay (Hologic). 2020-04-28
Telemedicine in the Era of COVID-19: The Virtual Orthopaedic Examination. Future directions include the development of validated, modified examination techniques and new technology that will allow for improved interactive physical examinations, as we rapidly move forward into the realm of telemedicine due to unexpected necessity. 2020-05-16
Retrospective analysis of laboratory testing in 54 patients with severe- or critical-type 2019 novel coronavirus pneumonia. Timely analysis of the laboratory characteristics associated with 2019 novel coronavirus pneumonia (COVID-19) can assist with clinical diagnosis and prognosis. 2020-05-08
Prediction of numbers of the accumulative confirmed patients (NACP) and the plateau phase of 2019-nCoV in China. But for Hubei Province, the subjects of Wuhan City and Hubei Province were included from the time of admission to the Huoshenshan Hospital to present day in order to ensure that all or the majority of the confirmed and suspected patients were collected for diagnosis and treatment. 2020-05-16
[Nosocomial infection with SARS-Cov-2 within Departments of Digestive Surgery]. The median time from admission to diagnosis of SARS-Cov-2 infection was 34 days (5-61 days). […] In 12 patients (80%), the diagnosis was made after a hospital stay of more than 14 days (15-63 days). 2020-04-28
[What do surgeons need to know about the digestive disorders and paraclinical abnormalities induced by COVID-19?] In some doubtful cases, virologic assessment of stool samples can yield definitive diagnosis. 2020-04-28
Chaos game representation dataset of SARS-CoV-2 genome. In the bioinformatics area, one of the crucial points is the analysis of the virus nucleotide sequences using approaches such as data stream, digital signal processing, and machine learning techniques and algorithms. 2020-05-21
Misdiagnosis in the COVID era: When Zebras are Everywhere, Don’t Forget the Horses. Even though we need to be vigilant in the diagnosis of COVID-19, we should not forget about the common pathologies. 2020-04-28
FDG-PET/CT findings highly suspicious for COVID-19 in an Italian case series of asymptomatic patients. To illustrate the [18F]FDG-PET/CT findings in patients affected by cancer with clinical diagnosis of Covid-19 METHODS: We retrospectively reviewed the cases of patients who showed pulmonary involvement unrelated to cancer metastases on March 13 and 16 2020. 2020-05-28
Conservation of personal protective equipment for head and neck cancer surgery during COVID-19 pandemic. Operative diagnosis and procedure; droplet count and distribution on face shields were documented. 2020-05-29
Objective evaluation of anosmia and ageusia in COVID-19 patients: Single-center experience on 72 cases. Otolaryngologists and head-neck surgeons must by now keep this diagnostic option in mind when evaluating cases of ageusia and nonspecific anosmia that arose suddenly and are not associated with rhinitis symptoms. 2020-05-29
Overview of COVID-19 testing and implications for otolaryngologists. We performed a literature review of current evidence surrounding SARS-CoV-2 diagnostic testing highlighting its utility, limitations, and implications for otolaryngologists. 2020-05-12
Case Report: Viral Shedding for 60 Days in a Woman with Novel Coronavirus Disease (COVID-19). This case demonstrates that viral shedding after COVID-19 diagnosis can be prolonged. 2020-04-28
Diagnostic performance of COVID-19 serology assays. Diagnosis of suspected cases is confirmed by nucleic acid assays with real-time PCR, using respiratory samples. […] A review of multiple reports and kit inserts on the diagnostic performance of rapid tests from various manufacturers that are commercially available were performed. […] There is much to determine regarding the value of serological testing in COVID-19 diagnosis and monitoring. 2020-04-30
Upper respiratory tract sampling in COVID-19. Routine nasopharyngeal swab of suspected COVID-19 infection should take anatomy of the nasal cavity into consideration to increase patient comfort and diagnostic yield. […] Routine oropharyngeal swab should be replaced by throat washing which has demonstrated better diagnostic accuracy, and it is safe towards others. 2020-04-30
Pediatric Microlaryngoscopy and Bronchoscopy in the COVID-19 Era. As an aerosol-generating procedure, traditional pediatric microlaryngoscopy and bronchoscopy techniques must be adapted in order to reduce the risk of transmission of severe acute respiratory syndrome coronavirus 2. […] The main outcome was the feasibility of technique, which was measured by ability to perform microlaryngoscopy and bronchoscopy with comparable success to the usual technique (ie, adequate examination of the patient for diagnostic procedures and ability to perform interventional procedures). 2020-05-05
Use of Tocilizumab for COVID-19-Induced Cytokine Release Syndrome: A Cautionary Case Report. We report two cases of patients who received a diagnosis of COVID-19 complicated by CRS and were treated with tocilizumab. 2020-05-06
COVID-19 pandemic-a focused review for clinicians. We describe the virological characteristics of SARS-CoV-2 and the clinical course of COVID-19 with an emphasis on diagnostic challenges, duration of viral shedding, severity markers and current treatment options. […] However, accurate diagnosis as well as early identification and management of high-risk severe cases are important for many clinicians. 2020-05-22
COVIDiagnosis-Net: Deep Bayes-SqueezeNet based diagnosis of the coronavirus disease 2019 (COVID-19) from X-ray images. In the ongoing process, radiological imaging is also preferred where chest X-rays are highlighted in the diagnosis. […] The SqueezeNet that comes forward with its light network design is tuned for the COVID-19 diagnosis with Bayesian optimization additive. […] Fine-tuned hyperparameters and augmented dataset make the proposed network perform much better than existing network designs and to obtain a higher COVID-19 diagnosis accuracy. 2020-05-18
Cancer patients and research during COVID-19 pandemic: A systematic review of current evidence. Moreover, the COVID-19 manifestations as well as its diagnosis are particular in this special population. 2020-05-28
Industry 4.0 technologies and their applications in fighting COVID-19 pandemic. The available technologies of Industry 4.0 could also help the detection and diagnosis of COVID-19 and other related problems and symptoms. 2020-05-27
Impact of COVID-19 on Nuclear Medicine in Germany, Austria and Switzerland: An International Survey in April 2020. Nearly all participants (97 %) report a decline of nuclear medicine diagnostic procedures. 2020-04-28
RT-qPCR Testing of SARS-CoV-2: A Primer. Testing for the presence of coronavirus is an essential diagnostic tool for monitoring and managing the current COVID-19 pandemic. 2020-05-01
Clinical characteristics of patients with 2019 coronavirus disease in a non-Wuhan area of Hubei Province, China: a retrospective study. Combining chest computed tomography images with the qPCR analysis of throat swab samples can improve the accuracy of COVID-19 diagnosis. 2020-04-30
COVID-19: Key Concepts for the Surgeon. In view of the current pandemic by SARS-CoV-2 it deems essential to understand the key concepts about the infection: its epidemiological origin, presentation, clinical course, diagnosis and treatment (still experimental in many cases). 2020-05-01
Scoping review of prevalence of neurologic comorbidities in patients hospitalized for COVID-19. We searched MEDLINE/PubMed, CINAHL (EBSCO), and Scopus databases for adult patients with preexisting neurologic disease who were diagnosed and hospitalized for COVID-19 or reported incidence of secondary neurologic events following diagnosis of COVID-19. 2020-05-29
Artificial intelligence vs COVID-19: limitations, constraints and pitfalls. In the meantime, extensive gathering of diagnostic data on who is infectious will be essential to save lives, train AI, and limit economic damages. 2020-05-01
Cancer care in the time of COVID-19-a perspective from Pakistan. This paper discusses the impact of coronavirus infection on cancer diagnosis and treatment in two leading cancer centres in Pakistan. […] There is an urgent need to evaluate the effect of delays in diagnosis and treatment on cancer stage and treatment, and to decide how to minimise these during likely future cycles of lockdown over the coming months and years. 2020-05-01
Clinical and imaging features of COVID-19. While CT examination serves as the screening and diagnostic basis for COVID-19, its accuracy is limited. […] The nucleic acid testing is the gold standard for the diagnosis of COVID-19, but has a low sensitivity is low. […] This paper reviews the published literature, guidelines and consensus, and summarizes the clinical and imaging characteristics of COVID-19, in order to provide a reliable basis for early diagnosis and treatment. 2020-05-11
Coronavirus disease 2019 (COVID-19) imaging reporting and data system (COVID-RADS) and common lexicon: a proposal based on the imaging data of 37 studies. We updated our published systematic review on imaging findings in COVID-19 to include 37 published studies pertaining to diagnostic features of COVID-19 in chest CT. […] The proposed COVID-RADS and common lexicon would improve the communication of findings to other healthcare providers, thus facilitating the diagnosis and management of COVID-19 patients. […] • The proposed COVID-RADS and common lexicon would improve the communication of findings to other healthcare providers, thus facilitating the diagnosis and management of COVID-19 patients. 2020-05-06
Neurological Implications of COVID-19 Infections. Here, we raise the importance of stringent diagnosis and data collection regarding neurological complications of COVID-19; we urge caution in the over-diagnosis of neurological disease where it does not exist, but equally strongly encourage the concerted surveillance for such conditions. 2020-05-01
Epidemiological and clinical features of asymptomatic patients with SARS-CoV-2 infection. The median time from exposure to diagnosis was 7.0 days (interquartile range [IQR]: 1.0-15.0 days). 2020-05-13
[Diagnosis, treatment, control and prevention of SARS-CoV-2 and coronavirus disease 2019: back to the future]. Since SARS-CoV-2 and SARS-CoV are closely related, previous findings on SARS-CoV are highly relevant to a better understanding as well as diagnosis, treatment, prevention and control of SARS-CoV-2. […] In this review, we highlight recent progresses in the field; compare the biological characteristics of SARS-CoV and SARS-CoV-2; summarize the urgently-needed diagnostic, treatment, prevention and control options; and provide future perspectives for the outcome of the outbreak and research questions to be answered, including some of the difficulties in vaccine development. 2020-05-01
[Optimization of a fluorescent qPCR detection for RNA of SARS-CoV-2]. Therefore, the optimized assay developed in this study can be used in screening and early clinical diagnosis. […] Our work provides a tool to facilitate rapid clinical diagnosis of COVID-19. 2020-05-01
The Effects of the COVID-19/SARS-CoV-2 Pandemic Outbreak on Otolaryngology Activity in Italy. The coronavirus disease 2019 (COVID-19) pandemic during the first months of 2020 is causing profound changes in worldwide health care systems, resulting in a major reduction of surgical interventions and routine non-urgent outpatient diagnostic procedures. […] Furthermore, as the current measures of lockdown continue, it will be difficult to perform scheduled and new diagnostic assessments, medical treatments and surgical procedures in a timely manner favoring the risk of diagnostic and therapeutic delays with severe impact on patients’ health. 2020-04-29
Strong associations and moderate predictive value of early symptoms for SARS-CoV-2 test positivity among healthcare workers, the Netherlands, March 2020. While our models would not justify presumptive SARS-CoV-2 diagnosis without molecular confirmation, it can contribute to targeted screening strategies. 2020-05-01
Which dermatology patients attend to Dermatology Outpatient Clinics during the SARS-CoV-2 outbreak in Turkey and what happened to them? Their age, sex, diagnosis of disease, requirement for emergent intervention, and their medical records about COVID-19 were obtained. 2020-05-22
The danger of neglecting melanoma during the COVID-19 pandemic. For the dermatology community, this interruption to the healthcare system can lead to delays in the diagnosis and treatment of melanoma. 2020-05-13
National Response to COVID-19 in the Republic of Korea and Lessons Learned for Other Countries. Identified strategies included early recognition of the threat and rapid activation of national response protocols led by national leadership; rapid establishment of diagnostic capacity; scale-up of measures for preventing community transmission; and redesigning the triage and treatment systems, mobilizing the necessary resources for clinical care. […] Key recommendations include (1) recognize the problem, (2) establish diagnostic capacity, (3) implement aggressive measures to prevent community transmission, (4) redesign and reallocate clinical resources for the new environment, and (5) work to limit economic impact through and while prioritizing controlling the spread and impact of COVID-19. 2020-05-04
Molecular-based Alternatives for Colorectal Cancer Screening during the COVID-19 Pandemic. The aim of this review is to demonstrate the potential utility of enhanced DNA-based stool testing for colorectal cancer screening and diagnosis during crises that strain available healthcare resources, such as the current COVID-19 pandemic. 2020-05-29
Pulmonary Embolism and Increased Levels of d-Dimer in Patients with Coronavirus Disease. These patients later showed development of persistent hypoxia with increased levels of d-dimer levels and were given a diagnosis of pulmonary embolisms. 2020-04-29
Correlation between Heart fatty acid binding protein and severe COVID-19: A case-control study. They were tested for HFABP after the diagnosis of COVID-19, and monitored for HFABP during their hospital stay. 2020-05-04
Ultrasound on the Frontlines of COVID-19: Report from an International Webinar. Imaging modalities such as chest radiography, thoracic and cardiovascular ultrasound, and computed tomography have roles in the diagnosis, prognosis, monitoring, and therapy of COVID-19. 2020-04-29
COVID-19 diagnosis and management: a comprehensive review. Real-time PCR is used as a diagnostic tool using nasal swab, tracheal aspirate or bronchoalveolar lavage samples. […] Computed tomography findings are important for both diagnosis and follow-up. 2020-05-13
Use of Radiographic Features in COVID-19 Diagnosis: Challenges and Perspectives. The stringent medical resources hinder the diagnostic capacity globally, while 84 thousands of new cases confirmed within a single day of 14 April 2020. […] Real-time reverse-transcriptase polymerase chain reaction (RT-PCR) with is the current first-line diagnosis, but the false-negative rate remains concerned. […] Radiographic technologies and tools, including Computed tomography (CT) and Chest X-ray (CXR), were applied for initial screening and follow-up, from which provides detail diagnosis with specific pathologic features for staging and treatment arrangement. […] In this review, we will discuss the challenges and the future perspectives of using radiographic modalities for COVID-19 diagnosis in view of securing human lives amid the crisis. 2020-04-29
Novel biosensor platforms for the detection of coronavirus infection and SARS-CoV-2. These platforms can facilitate routine diagnostic assays in certified clinical labs. 2020-04-29
Massively multiplexed nucleic acid detection with Cas13. To enable routine surveillance and comprehensive diagnostic applications, there is a need for detection technologies that can scale to test many samples1-3 while simultaneously testing for many pathogens4-6. […] Scalable, highly multiplexed CRISPR-based nucleic acid detection shifts diagnostic and surveillance efforts from targeted testing of high-priority samples to comprehensive testing of large sample sets, greatly benefiting patients and public health9-11. 2020-05-28
An Overview of Signal Processing Techniques for Remote Health Monitoring Using Impulse Radio UWB Transceiver. Although we have covered many topics related to health monitoring using IR-UWB, this paper is mainly focused on signal processing techniques for measurement of vital signs, i.e., respiration and heart rate monitoring. 2020-05-01
Toward a consensus view in the management of acute facial injuries during the Covid-19 pandemic. Efforts should be made to provide the best evidence-based care, which will mean revisiting old techniques, and risk stratifying patients on a case by case basis. 2020-05-02
The Role of Antibody Testing for SARS-CoV-2: Is There One? The absence of FDA oversight of serologic tests is concerning, given that the commercially available serologic assays are highly variable, differing in their format, the antibody class detected, the targeted antigen and the acceptable specimen types. 2020-04-30
Comparison of Commercially Available and Laboratory Developed Assays for in vitro Detection of SARS-CoV-2 in Clinical Laboratories. Multiple laboratory developed tests and commercially available assays have emerged to meet diagnostic needs related to the SARS-CoV-2 pandemic. 2020-04-30
An assessment of real-time RT-PCR kits for SARS-CoV-2 detection. We recently reported a laboratory diagnostic protocol for SARS-CoV-2 based on real-time RT-PCR assays using two primer sets, N and N2. […] On 30-31 January 2020, the protocol and reagents for these assays were distributed to local public health institutes and quarantine depots in Japan, and nationwide, SARS-CoV-2 diagnostic testing was started. […] These indicate that the protocol using the N and N2 sets is comparable to commercially available kits and is reliable for the laboratory diagnosis of COVID-19. 2020-04-30
Antibody responses to SARS-CoV-2 in patients with COVID-19. Serological testing may be helpful for the diagnosis of suspected patients with negative RT-PCR results and for the identification of asymptomatic infections. 2020-04-30
Use of CT and artificial intelligence in suspected or COVID-19 positive patients: statement of the Italian Society of Medical and Interventional Radiology. Italian radiology departments found themselves at the forefront in the management of suspected and positive COVID cases, both in diagnosis, in estimating the severity of the disease and in follow-up. […] In this emergency situation, several expectations have been raised by the scientific community about the role that artificial intelligence can have in improving the diagnosis and treatment of coronavirus infection, and SIRM wishes to deliver clear statements to the radiological community, on the usefulness of artificial intelligence as a radiological decision support system in COVID-19 positive patients. […] (3) Chest CT with artificial intelligence cannot replace molecular diagnosis tests with nose-pharyngeal swab (rRT-PCR) in suspected for COVID-19 patients. 2020-05-13
It’s not over until it’s over: the chameleonic behavior of COVID-19 over a six-day period. Radiological imaging plays a key role in the diagnostic process and during the monitoring of the clinical conditions especially of patients with severe symptoms. 2020-05-13
Analysis of vaginal delivery outcomes among pregnant women in Wuhan, China during the COVID-19 pandemic. A retrospective analysis of medical records and comparison of vaginal delivery outcomes between 10 pregnant women with clinical diagnosis of COVID-19 and 53 pregnant women without COVID-19 admitted to Zhongnan Hospital of Wuhan University between January 20 and March 2, 2020. […] Results of laboratory tests, imaging tests, and SARS-CoV-2 nucleic acid tests were also analyzed in neonates delivered by pregnant women with clinical diagnosis of COVID-19. […] Neonates delivered by pregnant women with clinical diagnosis of COVID-19 tested negative for SARS-CoV-2 infection. 2020-05-19
Epidemiological and clinical characteristics of 333 confirmed cases with coronavirus disease 2019 in Shanghai, China. Time intervals from onset to visit, hospitalization and diagnosis confirmed were all shortened after Shanghai’s first-level public health emergency response. 2020-05-13
The usual course of Thorax CT findings of Covid-19 infection and When should control Thorax CT scan? In the diagnosis of COVID-19, the polymerase chain reaction (RT-PCR) is considered as the reference standard test. […] In the early stages, thorax CT findings could be present even before the onset of symptoms, thorax CT has quite high sensitivity in COVID-19 patients with false negative RT-PCR results, and it has a great importance not only in diagnosis but also in follow up (6,7). […] We think that it might be beneficial for our radiologist colleagues in the early diagnosis of the imaging features of this disease, by sharing the experiences we have gained by evaluating the typical and relatively atypical CT findings regarding the natural course of the tomographic findings of COVID-19 and when to control CT. 2020-04-30
Common CT Findings of Novel Coronavirus Disease 2019 (COVID-19): A Case Series. Given the highly infectious nature of the coronavirus disease 2019 (COVID-19) virus and the lack of proven specific therapeutic drugs and licensed vaccines effective against it, early diagnosis of the disease is of paramount importance. 2020-04-30
A Coronavirus Disease 2019 (COVID-19) Patient with Multifocal Pneumonia Treated with Hydroxychloroquine. Early diagnosis and self-isolation or quarantine remain key to stemming the tide of the contagion as there is a real risk of the healthcare system being overwhelmed. 2020-05-05
Clinical and Epidemiological Characteristics of 1,420 European Patients with mild-to-moderate Coronavirus Disease 2019. Patients with positive diagnosis of Covid-19 were recruited from 18 European hospitals. 2020-04-30
Infection Control for CT Equipment and Radiographers’ Personal Protection During the Coronavirus Disease (COVID-19) Outbreak in China. OBJECTIVE. Because CT plays an important role in diagnosis, isolation, treatment, and effective evaluation of coronavirus disease (COVID-19), infection prevention and control management of CT examination rooms is important. CONCLUSION. We describe modifications to the CT examination process, strict disinfection of examination rooms, arrangement of waiting areas, and efforts to increase radiographers’ awareness of personal protection made at our institution during the COVID-19 outbreak. 2020-04-30
Strategies for radiology departments in handling the COVID-19 pandemic. Proactive measures, therefore, must be taken to ensure the continuation of diagnostic and interventional support to clinicians, while minimizing the risk of nosocomial transmission among staff and other patients. 2020-04-30
Radiological approach to COVID-19 pneumonia with an emphasis on chest CT. A fast and accurate diagnosis in this outbreak is critical to isolate and treat patients. […] Radiology plays an important role in the diagnosis and management of the patients. […] Shortcomings of the real-time reverse transcriptase-polymerase chain reaction test, including inappropriate sample collection and analysis methods, initial false negative results, and limited availability has led to widespread use of chest CT in the diagnostic algorithm. […] This review summarizes the role of radiology in COVID-19 pneumonia, diagnostic accuracy of imaging, and chest CT findings of the disease. 2020-04-30
Characteristics and diagnosis rate of 5630 subjects receiving SARS-CoV-2 nucleic acid tests from Wuhan, China. The positive result of nucleic acid test is a golden criterion to confirm SARS-CoV-2 infection, but the detection features remain unclear.METHODSWe performed a retrospective analysis in 5630 high-risk individuals receiving SARS-CoV-2 nucleic acid tests in Wuhan, China, and investigated their characteristics and diagnosis rates.RESULTSThe overall diagnosis rate was 34.7% (1952/5630). […] Furthermore, we investigated the association between diagnosis rate and the amount of testing in 501 subjects. […] Results revealed a 1.27-fold improvement (from 27.9% to 35.5%) of diagnosis rate from testing once to twice (P = 5.847 × 10-9) and a 1.43-fold improvement (from 27.9% to 39.9%) from testing once to 3 times (P = 7.797 × 10-14). […] Increasing the amount of testing could significantly improve diagnosis rates, except for subjects with pneumonia. 2020-05-25
Severe psychological distress among patients with epilepsy during the COVID-19 outbreak in southwest China. Univariate analyses associated both diagnosis of drug-resistant epilepsy and time spent paying attention to COVID-19 with severe psychological distress (defined as K-6 score >12; both P ≤ .001). […] Multivariate logistic regression identified two independent predictors of severe psychological distress: time spent paying attention to COVID-19 (odds ratio [OR] = 1.172, 95% confidence interval [CI] = 1.073-1.280) and diagnosis of drug-resistant epilepsy (OR = 0.283, 95% CI = 0.128-0.623). 2020-05-22
COVID-19 pandemic and personal protective equipment shortage: protective efficacy comparing masks and scientific methods for respirator reuse. Further studies testing UVGI and other decontamination techniques are an unmet need. 2020-05-30
Do psychiatric patients experience more psychiatric symptoms during COVID-19 pandemic and lockdown? A case-control study with service and research implications for immunopsychiatry. More than one-third of psychiatric patients might fulfil the diagnostic criteria post-traumatic stress disorder (PTSD). 2020-05-03
COVID-19 and Nigeria: putting the realities in context. Provision of quarantine or isolation facilities and availability of rapid diagnostic kits for fast and reliable testing and diagnosis of the disease can also be a challenge in Africa. 2020-05-29
Venous and arterial thromboembolic complications in COVID-19 patients admitted to an academic hospital in Milan, Italy. The high number of arterial and, in particular, venous thromboembolic events diagnosed within 24 h of admission and the high rate of positive VTE imaging tests among the few COVID-19 patients tested suggest that there is an urgent need to improve specific VTE diagnostic strategies and investigate the efficacy and safety of thromboprophylaxis in ambulatory COVID-19 patients. 2020-05-30
Comparison of the Panther Fusion and a laboratory-developed test targeting the envelope gene for detection of SARS-CoV-2. Numerous nucleic acid amplification assays have recently received emergency use authorization (EUA) for the diagnosis of SARS-CoV-2 infection, and there is a need to assess their test performance relative to one another. […] We performed a diagnostic comparison study by testing nasopharyngeal samples on the two assays. 2020-05-27
Epidemiological characteristics of coronavirus disease 2019 (COVID-19) patients in IRAN: A single center study. From February 19, 2020 to April 15, 2020, 12870 patients referred to the hospital emergency department, of which 2968 were hospitalized with COVID-19 diagnosis. 2020-05-27
Occupational exposure to SARS-CoV-2 in burns treatment during the COVID-19 epidemic: Specific diagnosis and treatment protocol. The key step to infection prevention is to identify risk points of infection exposure, strengthen the protection against those risk points, and formulate an appropriate diagnosis and treatment protocol. […] Following an in-depth study of the latest literature on COVID-19 diagnosis and treatment, we reviewed the protocols surrounding hospitalization of patients with extensive burns (area≥50 %) in our hospital from February 2009 to February 2019 and, in accordance with the epidemiological characteristics of COVID-19, developed an algorithm for protection during diagnosis and treatment of burns. […] Therefore, the aspects of medical protection and the diagnosis and treatment of burns appear to be particularly important during the prevention and control of the COVID-19. 2020-05-21
Do we know the diagnostic properties of the tests used in COVID-19? A rapid review of recently published literature. Diagnostic testing is critical for epidemiological surveillance, but the accuracy (sensitivity and specificity) and clinical utility (impact on health outcomes) of the current diagnostic methods used for SARS-CoV-2 detection are not known. […] I ran a quick search in PubMed/MEDLINE to find studies on laboratory diagnostic tests and rapid viral diagnosis. 2020-05-04
On Facing the SARS-CoV-2 (COVID-19) with Combination of Nanomaterials and Medicine: Possible Strategies and First Challenges. The applications of nanochemistry and general nanotechnology was also discussed to give the status of nanodiagnostic systems for COVID-19. 2020-05-01
The novel coronavirus (COVID-19) pneumonia with negative detection of viral ribonucleic acid from nasopharyngeal swabs: a case report. Nucleic acid detection is considered as the gold standard for the diagnosis of COVID-19. […] This case report described an effective supportive medication scheme to treat SARS-COV-2 infected patient and emphasized the necessity of detection of the viral genome using BALF samples and its significance in the diagnosis and prognosis of the disease. 2020-05-04
Guidance for the care of neuromuscular patients during the COVID-19 pandemic outbreak from the French Rare Health Care for Neuromuscular Diseases Network. Hospitalization should be reserved for emergencies, the conduct of treatments that cannot be postponed, check-ups for which the diagnostic delay may result in a loss of survival chance, and cardiorespiratory assessments for which the delay could be detrimental to the patient. 2020-05-03
Outcomes of COVID-19 in 79 patients with IBD in Italy: an IG-IBD study. This Italian prospective observational cohort study enrolled consecutive patients with an established IBD diagnosis and confirmed COVID-19. […] Age over 65 years (p=0.03), UC diagnosis (p=0.03), IBD activity (p=0.003) and a CCI score >1 (p=0.04) were significantly associated with COVID-19 pneumonia, whereas concomitant IBD treatments were not. 2020-05-28
Clinical evaluation of a rapid colloidal gold immunochromatography assay for SARS-Cov-2 IgM/IgG. At present, diagnosis COVID-19 were based on real-time RT-PCR, which have to be performed in biosafe laboratory and is unsatisfactory for suspect case screening. […] Therefore, there is an urgent need for rapid diagnostic test for COVID-19. […] To evaluate the diagnostic performance and clinical utility of the colloidal gold immunochromatography assay for SARS-Cov-2 specific IgM/IgG anti-body detection in suspected COVID-19 cases. […] At least two samples of each patient were collected for RT-PCR assay analysis, and the PCR results were performed as the reference standard of diagnosis. […] The colloidal gold immunochromatography assay for SARS-Cov-2 specific IgM/IgG anti-body had 71.1% sensitivity and 96.2% specificity in this population, showing the potential for a useful rapid diagnosis test for COVID-19. 2020-05-03
Comprehensive update on current outbreak of novel coronavirus infection (2019-nCoV). Herein, we aim to discuss the latest updates on the origin, genomic characteristics, diagnosis, treatment options and current efforts being made by international health organizations with regards to the 2019-nCoV outbreak. 2020-05-05
Delayed Radical Prostatectomy is Not Associated with Adverse Oncological Outcomes: Implications for Men Experiencing Surgical Delay Due to the COVID-19 Pandemic. Immediate RP was defined as RP within 3-months of diagnosis, while delayed RP was analyzed in 3-month intervals up to 12-months. 2020-05-01
Addressing multiple gastroenterological aspects of coronavirus disease 2019. Gastroenterologists and members of other medical specialties should also remember that the current epidemiological situation has changed diagnostic and therapeutic algorithms in the management of several gastrointestinal and liver disorders. 2020-05-29
[COVID-19 - More Lung Pocus and Sparing Use of Stethoscope, Chest X-Ray and Lung CT]. COVID-19 - More Lung Pocus and Sparing Use of Stethoscope, Chest X-Ray and Lung CT Abstract. For an optimal management of COVID-19 (Coronary Virus Disease) we depend on a fast and reliable diagnosis and severity assessment. […] Moreover, all three diagnostic examination techniques expose physicians, support staff and subsequent patients to an additional risk of exposure. 2020-05-01
The role of imaging in the detection and management of COVID-19: a review. Lung infection or pneumonia is the common complication of COVID-19, and imaging techniques, especially computed tomography (CT), have played an important role in diagnosis and treatment assessment of the disease. 2020-05-01
Role of respirators in controlling the spread of novel coronavirus (COVID-19) amongst dental healthcare providers: a review. This review discusses respirators, their purpose, types, clinical efficiency and proper donning and doffing techniques. 2020-05-29
SARS-CoV-2 pandemic and repercussions for male infertility patients: A proposal for the individualized provision of andrological services. In both scenarios, the “fertility window” may be transitory; postponing diagnostic semen analysis and sperm banking in these men could compromise the prospects of biological parenthood. 2020-05-23
Respiratory sampling for severe acute respiratory syndrome coronavirus 2: An Overview. A plethora of respiratory sampling methods for SARS-CoV-2 viral detection has been used and in the current evolving situation, there is no international consensus on the recommended method of respiratory sampling for diagnosis. 2020-05-08
COVID-19 Deaths: Are We Sure It Is Pneumonia? Please, Autopsy, Autopsy, Autopsy! The current outbreak of COVID-19 severe respiratory disease, which started in Wuhan, China, is an ongoing challenge, and a major threat to public health that requires surveillance, prompt diagnosis, and research efforts to understand this emergent pathogen and to develop an effective response. […] Due to the scientific community’s efforts, there is an increasing body of published studies describing the virus’ biology, its transmission and diagnosis, its clinical features, its radiological findings, and the development of candidate therapeutics and vaccines. […] Selective approaches to postmortem diagnosis, such as limited postmortem sampling over full autopsy, can also be useful in the control of disease outbreaks and provide valuable knowledge for managing appropriate control measures. 2020-05-04
COVID-19: A Geriatric Emergency. There is an urgent need to share expertise and clinical management skills with geriatricians as well as the need for early diagnosis to start treatment at the earliest convenience in the community, with the aim to avoid the collapse of intensive care units. 2020-05-04
Kinetics of SARS-CoV-2 specific IgM and IgG responses in COVID-19 patients. Serum antibody testing is becoming one of the critical methods for the diagnosis of COVID-19 patients. 2020-05-14
Case Fatality Rate of Cancer Patients with COVID-19 in a New York Hospital System. A total of 218 COVID-19 positive patients from March 18th-April 8th, 2020 with a malignant diagnosis were identified. 2020-05-06
COVID-19 outbreak in Italy: experimental chest X-ray scoring system for quantifying and monitoring disease progression. Although chest X-ray (CXR) is considered not sensitive for the detection of pulmonary involvement in the early stage of the disease, we believe that, in the current emergency setting, CXR can be a useful diagnostic tool for monitoring the rapid progression of lung abnormalities in infected patients, particularly in intensive care units. 2020-05-13
Radiographic severity index in COVID-19 pneumonia: relationship to age and sex in 783 Italian patients. To improve the risk stratification of patients infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), an experimental chest X-ray (CXR) scoring system for quantifying lung abnormalities was introduced in our Diagnostic Imaging Department. 2020-05-13
Tracheostomy during COVID-19 pandemic-Novel approach. Operative diagnosis; droplet count and distribution on plastic sheet and face shields were documented. 2020-05-06
Longitudinal Change of SARS-Cov2 Antibodies in Patients with COVID-19. Our results indicate that serological tests could be powerful approach for the early diagnosis of COVID-19. 2020-05-06
Evaluation of COVID-19 RT-qPCR test in multi-sample pools. Though diagnostic tests are fundamental to the ability to detect and respond, overwhelmed healthcare systems are already experiencing shortages of reagents associated with this test, calling for a lean immediately-applicable protocol. 2020-05-06
The first, holistic immunological model of COVID-19: implications for prevention, diagnosis, and public health measures. This “quantitative and time-sequence dependent” model has several implications for prevention, diagnosis, and therapy of COVID-19 at all ages. 2020-05-02
Clinical Course of COVID-19 in a Liver Transplant Recipient on Hemodialysis and Response to Tocilizumab Therapy: A Case Report. We also highlight the role of lung ultrasonography in early diagnosis of the inflammatory phase of COVID-19. 2020-05-02
COVID-19: impact on colorectal surgery. With the ongoing need for urgent and emergency colorectal surgery, including surgery for colorectal cancer, several questions pertaining to operating room (OR) utilization and techniques needed to be rapidly addressed. 2020-05-22
COVID-19 and Neonatal Respiratory Care: Current Evidence and Practical Approach. The novel coronavirus disease 2019 (COVID-19) pandemic has urged the development and implementation of guidelines and protocols on diagnosis, management, infection control strategies, and discharge planning. 2020-05-02
Characteristics of Endodontic Emergencies during Coronavirus Disease 2019 Outbreak in Wuhan. Body temperature was measured and acquired for each patient, a coronavirus disease 2019 (COVID-19) epidemiologic investigation questionnaire was given to each patient, an endodontic diagnosis was determined for the offending tooth, and a verbal numerical rating scale (VNRS) was used to record pain levels. 2020-05-26
The Diagnosis of Pneumonia in a Pregnant Woman with COVID-19 Using Maternal Lung Ultrasound. We report our experience on lung ultrasound examination in the diagnosis of Sars-Cov-2 pneumonia in a pregnant woman. […] We suggest point of care lung ultrasound examination as a diagnostic imaging tool in pregnant women with suspected COVID-19. 2020-05-05
What do surgeons need to know about the digestive disorders and paraclinical abnormalities induced by COVID-19? In some doubtful cases, virologic assessment of stool samples can yield definitive diagnosis. 2020-05-05
Cytokine storm intervention in the early stages of COVID-19 pneumonia. Guidelines for the diagnosis and treatment of SARS-CoV-2 infected pneumonia were first published January 30th, 2020; these guidelines recommended for the first time that cytokine monitoring should be applied in severely ill patients to reduce pneumonia related mortality. 2020-05-13
2019 Novel coronavirus disease (COVID-19) in hemodialysis patients: A report of two cases. To analyze the diagnosis and treatment of patients with chronic renal failure complicated with novel coronavirus pneumonia, and to evaluate the effect of blood purification technology on the treatment and prognosis of such patients. 2020-05-11
Epidemiological and clinical characteristics analysis of COVID-19 in the surrounding areas of Wuhan, Hubei Province in 2020. Of the patients, 67.1 % were originally healthy people with no underlying diseases, others mostly had common comorbidities including hypertension (12.3 %) and diabetes (5.5 %), 10.9 % were current smokers, 30.1 % had low white blood cell counts and 45.2 % showed decreased lymphocytes at the first time of diagnosis. […] The epidemiological characteristics of patients in the area around Wuhan, such as Shiyan, at first diagnosis are described as follows: Patients had histories of Wuhan residences in the early stage and family clustering in the later period. […] The initial diagnosis of the patients was mostly ordinary, and the percentage of critical patients who evolved into the ICU during follow-up is 2.7 %, which is lower than the 26.1 % reported by Wuhan city. […] According to the Shiyan experience, early diagnosis with multiple swaps of the Q-PCR test and timely treatment can reduce the death rate. […] No evidence exists that smoking protects COVID-19 patients from developing to severe/critical cases, and the absolute number of lymphocytes at initial diagnosis could not predict the progression risk from severe to critical condition. 2020-05-30
Acute limb ischemia in patients with COVID-19 pneumonia. All 20 patients already had a diagnosis of COVID-19 pneumonia. 2020-05-15
Clinical characteristics of asymptomatic and symptomatic patients with mild COVID-19. Diagnosis of COVID-19 was confirmed by real-time RT-PCR. 2020-05-29
Virtual Ophthalmology: Telemedicine in a Covid-19 Era. Review of the current telehealth landscape including usage, policies, and techniques for ambulatory practice integration. 2020-05-06
New understanding of the damage of SARS-CoV-2 infection outside the respiratory system. In this paper, we will systematically review the pathogenic features, transmission routes, and infection mechanisms of SARS-CoV-2, as well as any adverse effects on the digestive system, urogenital system, central nervous system, and circulatory system, in order to provide a theoretical and clinical basis for the diagnosis, classification, treatment, and prognosis assessment of SARS-CoV-2 infection. 2020-05-21
Comparing the analytical performance of three SARS-CoV-2 molecular diagnostic assays. The rapid spread of the virus challenged diagnostic laboratories to rapidly develop molecular diagnostic methods. […] As SARS CoV-2 assays became available for testing on existing molecular platforms, laboratories devoted unprecedented energy and resources into evaluating the analytical performance of the new tests and in some cases developed their own diagnostic assays under FDA-EUA guidance. 2020-05-27
Loop mediated isothermal amplification (LAMP) assays as a rapid diagnostic for COVID-19. Many nations are employing combinations of containment and mitigation strategies, where early diagnosis of COVID-19 is vital in controlling illness progression and limiting viral spread within the population. […] These requirements coupled with associated financial pressures may prevent effective deployment of such diagnostic tests. […] We hypothesise that recent advancements in enhanced LAMP protocols assay perhaps represent the best chance for a rapid and robust assay for field diagnosis of COVID-19, without the requirement of specialized equipment and highly trained professionals to interpret results. […] We hope that this strategy could be applied rapidly, and confirmed for viability with clinical samples, before being rolled out for mass-diagnostic testing in these current times. 2020-05-12
A new era for nuclear medicine. There have already been papers on the radiology preparedness that should be applied to radiology and nuclear medicine departments to support the care of patients with COVID-19 and maintain radiologic diagnostic and interventional support for the entirety of the hospital and healthcare system, particularly for emergencies, without jeopardizing an outbreak in the units. […] Since most nuclear medicine diagnostic and therapeutic interventions are non-urgent, the general guidance from the International Atomic Energy Agency (IAEA) for infection prevention and control is to postpone scheduled procedure after cautious risk assessment, with certain exceptions. 2020-05-05
Correspondence: Importance of the validated serum biochemistry and hemogram parameters for rapid diagnosis and to prevent false negative results during COVID-19 pandemic. Bioinformatics techniques such as artificial intelligence should be used for collecting the hemogram and serum biochemistry data of all COVID-19- infected people worldwide, even they do not show severe symptoms. […] These data may help find a biomarker that can be used in combination with the CT results for rapid and accurate diagnosis of COVID-19. 2020-05-21
Estimated effect of COVID-19 lockdown on melanoma thickness and prognosis: a rate of growth model. Uncertainty about the duration of these measures led us to consider the potential impact of diagnostic delays due to the paralyzation of certain health procedures and services on the prognosis of patients with melanoma. 2020-05-03
The role of triage in the prevention and control of COVID-19. The diagnosis of COVID-19 was based on positive COVID-19 nucleic acid testing according to the unified triage standards of the Guidelines for the Diagnosis and Treatment of Novel Coronavirus Pneumonia (Trial version 4),4 issued by the National Health Commission of the People’s Republic of China. 2020-05-20
Association Between Clinical Manifestations and Prognosis in Patients with COVID-19. The COVID-19 diagnostic standard was polymerase chain reaction detection of target genes of 2019 novel coronavirus (2019-nCoV). 2020-05-06
SEPAR and AEER consensus recommendations on the Use of Bronchoscopy and Airway Sampling in Patients with Suspected or Confirmed COVID-19 Infection. This consensus document has been drawn up by the Techniques and Transplantation and Nursing areas of the Spanish Society of Pulmonology and Thoracic Surgery (SEPAR) and the Spanish Society of Respiratory Endoscopy (AEER) with the aim of providing information on the safe and effective use of bronchoscopy in patients with suspected or confirmed COVID-19 infection. 2020-05-16
Intensive care during the 2019-coronavirus epidemic. This narrative literature review aims to gather the main contributions in the area of intensive care to date in relation to the epidemiology, clinic, diagnosis and management of 2019-nCoViD. 2020-05-04
Severe acute respiratory illness surveillance for coronavirus disease 2019, India, 2020. Data were extracted from Virus Research and Diagnostic Laboratory Network for analysis. 2020-05-06
Composite Monte Carlo decision making under high uncertainty of novel coronavirus epidemic using hybridized deep learning and fuzzy rule induction. Instead of applying simplistic and uniform assumptions for a MC which is a common practice, a deep learning-based CMC is used in conjunction of fuzzy rule induction techniques. 2020-05-07
COVID-19, Modern Pandemic: A Systematic Review From Front-Line Health Care Providers’ Perspective. The main aim of this systematic review is to provide a comprehensive clinical summary of all the available data from high-quality research articles relevant to the epidemiology, demographics, trends in hospitalization and outcomes, clinical signs and symptoms, diagnostic methods and treatment methods of COVID-19, thus increasing awareness in health care providers. 2020-05-07
Recommended prophylactic and management strategies for severe acute respiratory syndrome coronavirus 2 infection in transplant recipients. Based on the current epidemic situation, this study reviewed publications on this virus and coronavirus disease 2019 (COVID-19), analyzed common features of respiratory viral pneumonias, and presented the currently reported clinical characteristics of COVID-19 in transplant recipients to improve strategies regarding the diagnosis and treatment of COVID-19 in this special population. 2020-05-07
Epidemiological features and medical care-seeking process of patients with COVID-19 in Wuhan, China. The diagnostic evaluation process of suspected patients needs to be accelerated at the epicentre of the outbreak and early isolation of infected patients in a healthcare setting rather than at home is urgently required to stop the spread of the virus. 2020-05-07
Severe ARDS in COVID-19-infected pregnancy: obstetric and intensive care considerations. We present a case of rapid clinical decompensation and development of severe Acute Respiratory Distress Syndrome (ARDS) in a woman at 31 weeks’ gestation to highlight these unique considerations and present an algorithmic approach to the disease’s diagnosis and management. 2020-05-04
Smell and taste symptom-based predictive model for COVID-19 diagnosis. A model using all 5 diagnostic symptoms had the highest accuracy with a predictive ability of 82% in discriminating between COVID-19 results. […] To maximize sensitivity and maintain fair diagnostic accuracy, a combination of 2 symptoms, change in sense of smell or taste and fever was found to have a sensitivity of 70% and overall discrimination accuracy of 75%. 2020-05-04
Response of a comprehensive cancer center to the COVID-19 pandemic: the experience of the Fondazione IRCCS-Istituto Nazionale dei Tumori di Milano. Of these, 47 were hospitalized, 53 needed a differential diagnosis to continue with their cancer treatment, and 201 were about to undergo surgery. 2020-05-04
The diagnostic value of rapid anti IgM and IgG detecting tests in the identification of patients with SARS CoV-2 virus infection These results strongly support that Anhui and Clungene rapid tests detecting IgM and IgG antibodies against SARS-CoV-2 virus should not be used in the differential diagnosis of infection. 2020-05-06
Typical radiological progression and clinical features of patients with coronavirus disease 2019. Evaluating chest CT, clinical symptoms, and laboratory results could facilitate the early diagnosis of COVID-19, and judge disease progression. 2020-05-26
Electrochemical biosensors for pathogen detection. Electrochemical biosensors for pathogen detection are broadly reviewed in terms of transduction elements, biorecognition elements, electrochemical techniques, and biosensor performance. 2020-05-06
Diagnostic performance between CT and initial real-time RT-PCR for clinically suspected 2019 coronavirus disease (COVID-19) patients outside Wuhan, China. The diagnostic value of CT is unclear. […] No statistical difference was found in the diagnostic performance between initial RT-PCR and chest CT. […] Initial RT-PCR and chest CT had comparable diagnostic performance in identification of suspected COVID-19 patients outside the epidemic center. 2020-05-29
Association between chest CT features and clinical course of Coronavirus Disease 2019. There are several specific image changes along with the disease progression may be helpful in early recognition and differential diagnosis of Coronavirus Disease 2019. 2020-05-29
Caution regarding potential changes in AVR practices during the COVID-19 pandemic. For patients with severe aortic stenosis, efforts to bring treatment to symptomatic patients amid this pandemic might lead to favored use of catheter based management using minimalist techniques that do not require these elements. 2020-05-04
Lab-on-a-Chip Technologies for the Single Cell Level: Separation, Analysis, and Diagnostics. The techniques mentioned herein have already had significant impacts in our lives, from in-the-field diagnosis of disease and parasitic infections, through home fertility tests, to uncovering the interactions between SARS-CoV-2 and their host cells. […] How do these techniques work? 2020-05-05
COVID-19 Surface Persistence: A Recent Data Summary and Its Importance for Medical and Dental Settings. As this was a current study, there are still not many sources in the literature, and scientific strategies are moving towards therapy and diagnosis, rather than knowing the characteristics of the virus. 2020-05-08
Harnessing the potential of CRISPR-based platforms to advance the field of hospital medicine. A Literature search was performed using PubMed [1 December 2019-17 April 2020].Expert opinion: This paper reviews the remarkable diagnostic and therapeutic potential of the CRISPR-Cas9 platform and concludes with a look at ethical issues and technical hurdles pertaining to the implementation of permanent gene modification in the practice of Hospital Medicine. 2020-05-14
Access to Telemedicine-Are We Doing All That We Can during the COVID-19 Pandemic? This “digital divide” is not fair to our patients in need-especially those with a cancer diagnosis. 2020-05-05
Guidance for the management of adult patients with coronavirus disease 2019. This article summarized the understanding of the etiology, pathogenesis, epidemiology, clinical characteristics, diagnosis, treatment, rehabilitation, and prevention and control measures of COVID-19 based on the available data and anti-epidemic experience in China. 2020-05-05
Coronavirus Disease 2019 (COVID-19): Chinese Radiologists are Acting. In fighting COVID-19, radiologic examinations played a critical role in the early diagnosis of COVID-19, and could also help assess disease course and severity. 2020-05-05
Artificial intelligence to codify lung CT in Covid-19 patients. Artificial intelligence (AI) software has been employed to facilitate CT diagnosis. […] In this communication, we present an example of a good tool for the radiologist (Thoracic VCAR software, GE Healthcare, Italy) in Covid-19 diagnosis (Pan et al. in Radiology, 2020. https://doi.org/10.1148/radiol.2020200370). […] Therefore, keeping in mind that CT has high diagnostic sensitivity in identifying lesions, but not specific for Covid-19 and similar to other infectious viral diseases, it is mandatory to have an AI software that expresses objective evaluations of the percentage of ventilated lung parenchyma compared to the affected one. 2020-05-13
Trends and Innovations in Biosensors for COVID-19 Mass Testing. Fast and widespread diagnosis is crucial to fighting against the outbreak of COVID-19. […] Molecular diagnostic assays based on quantitative reverse transcription polymerase chain reaction are used in most clinical laboratories. 2020-05-27
Impact of coronavirus disease 2019 (COVID-19) outbreak on outcome of myocardial infarction in Hong Kong, China. There was a reduction in daily emergency room attendance since January 25, 2020 (group 1,327/day vs. group 2,231/day) and 149 patients with diagnosis of MI were included into analysis (group 1 N = 85 vs. group 2 N = 64). 2020-05-05
Transient appearance of EDTA dependent pseudothrombocytopenia in a patient with 2019 novel coronavirus pneumonia. This case emphasized the importance of peripheral blood smear and clinical manifestation, especially in the differential diagnosis of thrombocytopenia. 2020-05-14
COVID-19 Dynamic Computed Tomography (CT) Performance and Observation of Some Laboratory Indicators. CONCLUSIONS The dynamic changes of CT images of lungs of COVID-19 patients, combined with the clinical manifestations and laboratory indicators of patients, can help guide clinical diagnosis and treatment. 2020-05-06
Co-Infection with SARS-COV-2 and Parainfluenza in a young adult patient with pneumonia: Case Report. The case represents the importance of prompt diagnosis and awareness of the potential co-infection with other respiratory viruses and this novel deadly virus. 2020-05-08
Hypertransaminasemia in the course of infection with SARS-CoV-2: Incidence and pathogenetic hypothesis. These patients may also present with less well-defined symptoms like diarrhea, nausea, vomiting and/or abdominal discomfort both at the time of diagnosis and during the clinical course. 2020-05-08
Pulmonary contusion mimicking COVID-19: A case report. Differential diagnosis of lung contusion and COVID-19 must be emphasized. 2020-05-08
The Indian perspective of COVID-19 outbreak. The present study review is on the general continent, virology, pathogenesis, global epidemiology, clinical presentation, diagnosis, treatment and control of COVID-19 with the reference to India. 2020-05-07
Eosinopenia and elevated C-reactive protein facilitate triage of COVID-19 patients in fever clinic: a retrospective case-control study. We compared the clinical features and laboratory findings of the two groups, and analyzed the diagnostic performance of several laboratory parameters in predicting SARS-CoV-2 infection and made relevant comparisons to the China diagnosis guideline of having a normal or decreased number of leukocytes (≤9•5 109/L) or lymphopenia (<1•1 109/L). […] The addition of eosinopenia alone or the combination of eosinopenia and elevated hs-CRP into the guideline-recommended diagnostic parameters for COVID-19 improved the predictive capacity with higher than zero of both net reclassification improvement (NRI) and integrated discrimination improvement (IDI). 2020-05-05
Guide for Nuclear Medicine Applications During the COVID-19 Outbreak. After the lung computerized tomography (CT) findings which are important in the diagnosis of COVID-19 are described, protection measures against infection were defined in radiology departments. […] There is no publication involving protection measures for diagnostic and therapeutic procedures in nuclear medicine (NM) (appointment, patient acceptance, imaging and treatment procedures, disinfection etc). […] These lung findings detected in hybrid images will be helpful in the early diagnosis of pulmonary involvement. 2020-05-14
Can Chest CT Features Distinguish Patients With Negative From Those With Positive Initial RT-PCR Results for Coronavirus Disease (COVID-19)? OBJECTIVE. The purpose of this study was to explore the value of CT in the diagnosis of coronavirus disease (COVID-19) pneumonia, especially for patients who have negative initial results of reverse transcription-polymerase chain reaction (RT-PCR) testing. MATERIALS AND METHODS. Patients with COVID-19 pneumonia from January 19, 2020, to February 20, 2020, were included. 2020-05-05
PSYCHIATRIC HOSPITALIZATION RATES IN ITALY BEFORE AND DURING COVID-19: DID THEY CHANGE? AN ANALYSIS OF REGISTER DATA. The reduction was visible for all diagnostic groups, except for a group of ‘Other’ diagnoses, which includes anxiety disorders, neurocognitive disorders, etc. 2020-05-05
The management of coronavirus disease 2019 (COVID-19). The management of COVID-19 should focus on early diagnosis, immediate isolation, general and optimized supportive care, and infection prevention and control. 2020-05-23
Cutaneous manifestations of a 21st century worldwide fungal epidemic possibly complicating the COVID-19 pandemic to jointly menace mankind. The identification of C. auris necessitates use of sophisticated technology not readily available to make this essential diagnosis since C. auris is multi-drug resistant and isolation precautions would become paramount. 2020-05-29
The Prevalence of Olfactory and Gustatory Dysfunction in COVID-19 Patients: A Systematic Review and Meta-analysis. Increased awareness of this fact may encourage earlier diagnosis and treatment, as well as heighten vigilance for viral transmission. 2020-05-05
Molecular testing for acute respiratory tract infections: clinical and diagnostic recommendations from the IDSA’s Diagnostics Committee. Highly sensitive and specific nucleic acid amplification tests have become the diagnostic reference standard for viruses and translation of bacterial assays from basic research to routine clinical practice represents an exciting advance in respiratory medicine. […] Here, we summarize the current state of the art with respect to the diagnosis of viral and bacterial RTIs, provide a practical framework for diagnostic decision-making using selected patient-centered vignettes, and make recommendations for future studies to advance the field. 2020-05-05
Management of the airway and lung isolation for thoracic surgery during the COVID-19 pandemic. The thoracic anaesthetic community has been confronted with the need to modify existing techniques to maximise safety for patients and healthcare professionals. 2020-05-05
Practical Advice for Management of IBD Patients during the COVID-19 Pandemic: A World Endoscopy Organization Statement. Here, the World Endoscopy Organisation (WEO) is providing practical advice for the management of IBD patients during the pandemic covering the diagnostic and therapeutic spectrum. 2020-05-05
Incidence of venous thromboembolism in hospitalized patients with COVID-19. The observed risk for VTE in COVID-19 is high, particularly in ICU patients, which should lead to a high level of clinical suspicion and low threshold for diagnostic imaging for DVT or PE. […] Future research should focus on optimal diagnostic and prophylactic strategies to prevent VTE and potentially improve survival. 2020-05-05
Endocrinology in the time of COVID-19: Management of pituitary tumours. Here, we summarize some of the diagnostic and management dilemmas for these patients, and we provide guidance on safe and as effective as possible delivery of care in the COVID-19 era. 2020-05-07
Dengue Fever and Severe Dengue in Barbados, 2008-2016. Diagnosis was confirmed either by DENV-specific real time reverse transcriptase polymerase chain reaction (rRT-PCR), or non-structural protein 1 (NS1) antigen or enzyme linked immunosorbent assay (ELISA) tests; a case fatality rate of 0.4% (10/3994) was observed. 2020-05-06
How Big Data and Artificial Intelligence Can Help Better Manage the COVID-19 Pandemic. Thanks to the latest advancements in the field of molecular and computational techniques and information and communication technologies (ICTs), artificial intelligence (AI) and Big Data can help in handling the huge, unprecedented amount of data derived from public health surveillance, real-time epidemic outbreaks monitoring, trend now-casting/forecasting, regular situation briefing and updating from governmental institutions and organisms, and health facility utilization information. 2020-05-11
Multi-tiered screening and diagnosis strategy for COVID-19: a model for sustainable testing capacity in response to pandemic. COVID-19 illuminates the need for a tiered diagnostic approach to rapidly identify clinically significant infections and reduce disease spread. […] A multi-tiered, diagnostic strategy incorporating a rapid host immune response assay as a screening test, molecular confirmatory testing and rapid IgM/IgG testing to assess benefit from quarantine/further testing and provide information on population exposure/herd immunity would efficiently evaluate potential COVID-19 patients. 2020-05-21
[Psychopathological consequences of confinement]. We quickly summarize the diagnostic and therapeutic approaches already in place, such as telemedicine, which is undergoing rapid development during the COVID-19 crisis. 2020-05-08
Potential Applications of Plant Biotechnology against SARS-CoV-2. There is a massive international effort underway to develop diagnostic reagents, vaccines, and antiviral drugs in a bid to slow down the spread of the disease and save lives. […] One part of that international effort involves the research community working with plants, bringing researchers from all over the world together with commercial enterprises to achieve the rapid supply of protein antigens and antibodies for diagnostic kits, and scalable production systems for the emergency manufacturing of vaccines and antiviral drugs. 2020-05-08
SARS-CoV-2 was already spreading in France in late December 2019. Here we report a case of a patient hospitalised in December 2019 in an intensive care unit in a hospital in the north of Paris for haemoptysis with no aetiological diagnosis. […] RT-PCR was performed retrospectively on the stored respiratory sample and confirmed the diagnosis of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. 2020-05-11
Using a diagnostic model based on routine laboratory tests to distinguish patients infected with SARS-CoV-2 from those infected with influenza virus. The differential diagnosis between novel coronavirus pneumonia patients (NCPP) and influenza patients (IP) remains a challenge in clinical practice. […] The diagnostic model based on a combination of 18 routine laboratory indicators showed an area under the curve of 0.796 (95% CI, 0.777-0.814), with a sensitivity of 46.93% and specificity of 90.09% when using a cut-off value of 0.598. […] A diagnostic model based on a combination of routine laboratory results provided an adjunct approach in the differential diagnosis between NCPP and IP. 2020-05-29
Family cluster of three recovered cases of pneumonia due to severe acute respiratory syndrome coronavirus 2 infection. Following treatment with oseltamivir and short-term methylprednisolone combined with symptomatic management, all three patients recovered within 3 weeks, as evidenced by the disappearance of their symptoms, clearance of pulmonary infiltrates and consecutive negative molecular diagnostic test findings. 2020-05-07
Lessons of the month 1: A case of rhombencephalitis as a rare complication of acute COVID-19 infection. Magnetic resonance imaging showed changes in keeping with inflammation of the brainstem and the upper cervical cord, leading to a diagnosis of rhombencephalitis. 2020-05-06
Respiratory Distress in Postanesthesia Care Unit: First Presentation of Coronavirus Disease 2019 in a 17-Year-Old Girl: A Case Report. Finally, a reverse transcriptase polymerase chain reaction (RT-PCR) of a pharyngeal specimen confirmed the diagnosis of COVID-19. 2020-05-08
Triage of Acute Ischemic Stroke in Confirmed COVID-19: Large Vessel Occlusion Associated With Coronavirus Infection. However, for acute stroke patients who have a diagnosis of or are under investigation for COVID-19, the concern for nosocomial transmission moderates operational procedures for acute stroke care. 2020-05-08
Radiological role in the detection, diagnosis and monitoring for the coronavirus disease 2019 (COVID-19). This review of current studies on COVID-19 provides insight into the radiological role in the detection, diagnosis, and monitoring for COVID-19. […] A combination of chest CT and repeat Reverse Transcription-Polymerase Chain Reaction (RT-PCR) testing may be beneficial for the diagnosis of COVID-19 in the setting of strongly clinical suspicion. […] Chest CT may improve the sensitivity for COVID-19 diagnosis, but patients’ exposure to radiation should be kept as low as possible especially for children and pregnant women patients. 2020-05-08
Coronavirus disease 2019: a clinical review. Here we present an overview of the viral structure, pathogenesis, diagnosis, and clinical features of COVID-19 based on the current state of knowledge, and we compare its clinical characteristics with SARS and Middle East Respiratory Syndrome (MERS). 2020-05-08
Clinical display, diagnostics and genetic implication of novel Coronavirus (COVID-19) epidemic. In this review, 73 research articles published before 25 March 2020 were analyzed to better understand the clinical characteristics of patients and to introduce the available serological, hematology and molecular diagnostic methods. […] We highlighted the role of HLA haplotype in virus infection as HLA typing will provide susceptibility information for personalized prevention, diagnosis, and treatment in future studies. 2020-05-08
Current practice and potential strategy in diagnosing COVID-19. Here we summarized relatively mature diagnostic methods like nuclear acid test and computed tomography. […] Especially, we also presented several novel techniques for diagnosing COVID-19 like lung ultrasound. […] Chinese Clinical Guidance for COVID-19 Pneumonia Diagnosis and Treatment (7th edition) by National Health Commission is recommended to follow as it provides detailed diagnostic procedures using currently available tools. 2020-05-08
A Critical Needs Assessment for Research in Companion Animals and Livestock Following the Pandemic of COVID-19 in Humans. What are the best diagnostic tests currently available for companion animals and livestock? 2020-05-28
[SARS-CoV-2, a point in the storm]. A limitation of the propagation, the understanding of the functioning of the virus and its clinical manifestations, the administration of specific treatments, rapid and reliable diagnostic tools are the basis of the fight against this germ, which is still little known today. 2020-05-08
[Emergency department : COVID-19 crisis and organizational aspects]. Diagnosis is based on PCR from a nasopharyngeal swab and emergency treatment rely on oxygen therapy. […] Le diagnostic repose sur la PCR à partir d’un frottis nasopharyngé et le traitement d’urgence sur l’oxygénothérapie. 2020-05-08
[Computed tomography (CT) utility for diagnosis and triage during COVID-19 pandemic]. The nasopharyngeal smear with PCR analysis is the first diagnostic test proposed to confirm infection with COVID-19 SARS-CoV-2. […] For this reason, the chest CT-scan has been proposed as a rapid triage tool for diagnosis in these suspect Covid-19 patients. […] However, its specificity is limited, exposing to the risk of over-diagnosis, and further data are needed to confirm its usefulness, and to highlight the possible prognostic value of the CT, in detecting early lesions associated with poor outcome, indicating the need for admission to intensive care. […] Aussi, le CT-scan thoracique a été proposé comme outil de triage rapide pour poser le diagnostic chez ces patients suspects de COVID-19. […] Toutefois, sa spécificité est limitée, exposant au risque de surdiagnostic. 2020-05-08
Practical Considerations When Performing Neurodiagnostic Studies on Patients with COVID-19 and Other Highly Virulent Diseases. In early to mid-March, there were no clear guidelines or recommendations available from neurodiagnostic-related organizations or hospitals on how to adapt procedure workflow to those with COVID-19. 2020-05-06
Autopsy Findings and Venous Thromboembolism in Patients With COVID-19. Autopsies performed at a single academic medical center, as mandated by the German federal state of Hamburg for patients dying with a polymerase chain reaction-confirmed diagnosis of COVID-19. 2020-05-23
Rapid implementation of an evidence-based remote triaging system for assessment of suspected referrals and patients with head and neck cancer on follow-up after treatment during the COVID-19 pandemic: Model for international collaboration. For suspected referrals with cancer, we adapted the Head and Neck Cancer Risk Calculator (HaNC-RC)-V.2, generated from 10 244 referrals with the following diagnostic efficacy metrics: 85% sensitivity, 98.6% negative predictive value, and area under the curve of 0.89. 2020-05-11
Pathophysiological characteristics and therapeutic approaches for pulmonary injury and cardiovascular complications of coronavirus disease 2019. Diverse clinical manifestations and laboratory abnormalities occur in patients with cardiovascular injury in COVID-19, characterizing the development of this complication, as well as providing clues to diagnosis and treatment. 2020-05-08
Fetal Diagnosis and Therapy during the COVID-19 Pandemic: Guidance on Behalf of the International Fetal Medicine and Surgery Society. The COVID-19 pandemic has stressed patients and healthcare givers alike and challenged our practice of antenatal care, including fetal diagnosis and therapy. 2020-05-06
Covid-19: implications for prehospital, emergency and hospital care in patients with acute coronary syndromes. This paper describes, besides general measures in times of a pandemic, also the necessary changes in the invasive diagnosis and treatment of patients presenting with different entities of acute coronary syndromes including structural adaptations (networks, spokes and hub centres) and therapeutic adjustments. 2020-05-29
Ensuring adequate health financing to prevent and control the COVID-19 in Iran. The government has also made efforts to divulge high-quality information concerning the COVID-19 and to provide laboratories and hospitals with diagnostic kits and adequate resources to treat patients. 2020-05-11
[Informations on psychotropics and their adaptations for patients suffering from mental disorders in France during the SARS-CoV-2 epidemic]. Psychiatrists need to know: (i) how to identify, the risks associated with the prescription of psychotropic drugs and which can prove to be counterproductive in their association with COVID-19 (coronavirus disease 2019), (ii) how to assess in terms of benefit/risk ratio, the implication of any hasty and brutal modification on psychotropic drugs that can induce confusion for a differential diagnosis with the evolution of COVID-19. 2020-05-09
A logistic growth model for COVID-19 proliferation: experiences from China and international implications in infectious diseases. We conducted diagnosis of the residuals and also its goodness of fit with testing data from Mar. 13 to Apr. 2020-05-09
Viral kinetics of SARS-CoV-2 in asymptomatic carriers and presymptomatic patients. The median number of days to first negative RT-PCR in the asymptomatic carriers was 4.5 (range 2.5-9), and all asymptomatic carriers reached a first RT-PCR Ct>35 within 14 days after diagnosis. […] Patients who have COVID-19 may already be infectious before there are symptoms, and 14 days of isolation after diagnosis may be sufficient in entirely asymptomatic cases. 2020-05-29
Evidence for and against vertical transmission for SARS-CoV-2 (COVID-19). Perinatal exposure, including mode of delivery and time interval from delivery to the diagnosis of neonatal infection are crucial in differentiating congenital from perinatal infection. 2020-05-10
[Consensus of Chinese experts on diagnosis and treatment processes of acute myocardial infarction in the context of prevention and control of COVID-19 (first edition)]. To standardize the management and facilitate the diagnosis and treatment, we formulated the guidelines for the procedures and strategies for the diagnosis and treatment of AMI, which highlight 5 Key Principles, namely Nearby treatment, Safety protection, Priority of thrombolysis, Transport to designated hospitals, and Remote consultation. 2020-05-08
[Dandelion clock-like sign on CT for diagnose of COVID-19]. To explore the value of the “dandelion clock-like” sign on chest CT for diagnosis of SARS-CoV-2-associated pneumonia. 2020-05-08
[Laboratory testing techniques for SARS-CoV-2]. The selection of appropriate detection techniques and methods for accurate and rapid identification of pathogens therefore plays a key role in improving the diagnosis and treatment of the patients and containing the outbreak. […] These techniques are expected to provide valuable assistance in controlling the epidemic and new ideas for future researches. 2020-05-08
[Effect of heat inactivation of blood samples on the efficacy of three detection methods of SARS-CoV-2 antibodies]. This retrospective study was conducted in 11 patients with established diagnosis of COVID-19 and 10 patients with diseases other than COVID- 19 in our hospital. 2020-05-11
[Correlation between clinical classification of COVID-19 and imaging characteristics of MSCT volume scanning of the lungs]. According to the Fifth Edition of the Diagnosis and Treatment Guidelines by the National Health Commission, the patients were divided into common type, severe type and critical type. […] MSCT volume scanning not only allows early diagnosis of COVID-19 but also provides evidence for evaluating the severity of COVID-19 to assist in the clinical treatment of the patients. 2020-05-11
[An increased neutrophil/lymphocyte ratio is an early warning signal of severe COVID-19]. Multivariate logistic regression analysis showed that NLR was an independent risk factor for severe COVID-19 (OR=1.264, 95% CI: 1.046-1.526, P=0.015) with an AUC of 0.831 (95% CI: 0.730-0.932), an optimal diagnostic threshold of 4.795, a sensitivity of 0.839, and a specificity of 0.750. 2020-05-11
[Diagnosis and treatment of an elderly patient with secondary cerebral infarction caused by COVID-19]. We review the experience with the diagnosis and treatment of secondary cerebral infarction in an elderly patient with coronavirus disease 2019 (COVID-19). 2020-05-11
Detecting and Monitoring Porcine Hemagglutinating Encephalomyelitis Virus, an Underresearched Betacoronavirus. Assessment of the diagnostic performance of the PHEV S1 ELISA using serum samples (n = 924) collected from 7-week-old pigs (n = 84; 12 pigs per group) inoculated with PHEV, porcine epidemic diarrhea virus, transmissible gastroenteritis virus, porcine respiratory coronavirus, or porcine deltacoronavirus showed that a sample-to-positive cutoff value of ≥0.6 was both sensitive and specific, i.e., all PHEV-inoculated pigs were seropositive from days postinoculation 10 to 42, and no cross-reactivity was observed in samples from other groups. 2020-05-20
Gene of the month: the 2019-nCoV/SARS-CoV-2 novel coronavirus spike protein. The fundamental role of the spike protein in infectivity suggests that it is an important target for vaccine development, blocking therapy with antibodies and diagnostic antigen-based tests. 2020-05-07
First Case of an Infant with COVID-19 in the Middle East. These findings serve as a practical reference for the clinical diagnosis and medical treatment of children with COVID-19. 2020-05-09
Novel Coronavirus (2019-nCoV) in Disguise. It also serves as an example of how healthcare providers may need to increase their suspicion for COVID-19 to ensure self-protection and prompt diagnosis in the era of an ongoing pandemic. 2020-05-09
A Cautionary Tale of False-Negative Nasopharyngeal COVID-19 Testing. There remains diagnostic uncertainty regarding the sensitivity of reverse transcription polymerase chain reaction in detection of SARS-CoV-2 from nasopharyngeal specimens. 2020-05-09
Need for Caution in the Diagnosis of Radiation Pneumonitis in the COVID-19 Pandemic. As this pandemic continues, patients with symptoms of RP require diagnostic attention. 2020-05-10
COVID-19 in Older People: A Rapid Clinical Review. Viral-PCR and serology are the mainstays of testing but a positive diagnosis may be increasingly supported by radiological findings. 2020-05-29
Application of nanomaterials in treatment, anti-infection and detection of coronaviruses. This article aims to provide an overview of recent studies on the effectiveness of nanoparticles as diagnostic or antiviral tools against coronaviruses. 2020-05-07
COVID-19 - Toward a comprehensive understanding of the disease. Last but not least, currently available and possible future therapeutic and diagnostic options are briefly commented on. 2020-05-29
Loss of smell or taste as the only symptom of COVID-19. Together, these findings may inform future research, diagnosis, prevention and treatment of COVID-19. 2020-05-12
COVID-19: POSTMORTEM DIAGNOSTIC AND BIOSAFETY CONSIDERATIONS. While in some cases a history of fever and/or respiratory distress (e.g. cough or shortness of breath) may suggest the diagnosis, epidemiologic studies indicate that the majority of individuals infected with COVID-19 develop mild to no symptoms. […] A case of sudden unexpected death due to COVID-19 is presented as a means of illustrating common autopsy findings, as well as diagnostic and biosafety considerations. 2020-05-09
Mortality Rates of Patients with Proximal Femoral Fracture in a Worldwide Pandemic: Preliminary Results of the Spanish HIP-COVID Observational Study. All patients who were ≥65 years of age, presented to the Emergency Department of the participating hospitals during this period with a diagnosis of proximal femoral fracture, and had a minimum follow-up of 10 days were included in the cohort. 2020-05-07
Emerging Biomolecular Testing to Assess the Risk of Mortality from COVID-19 Infection. Although several approaches have been used/developed (or are being developed/suggested) to diagnose COVID-19 infection, no approach is available/proposed for fast diagnosis of COVID-19 infections likely to be fatal. 2020-05-23
Improving Detection and Response to Respiratory Events - Kenya, April 2016-April 2020. Activities were selected based on existing capacity and determined by the Kenya MoH and included 1) expansion of severe acute respiratory illness (SARI) surveillance sites; 2) piloting of community event-based surveillance; 3) expansion of laboratory diagnostic capacity; 4) training of public health practitioners in detection, investigation, and response to respiratory threats; and 5) improvement of response capacity by the national emergency operations center (EOC). 2020-05-08
T cell subset counts in peripheral blood can be used as discriminatory biomarkers for diagnosis and severity prediction of COVID-19. This study evaluated the significance of lymphocyte subsets detection in peripheral blood in the diagnosis and prognosis of coronavirus disease 2019 (COVID-19). […] The counts of CD8+T and CD4+T cells can be used as diagnostic markers of COVID-19 and predictors of disease severity. 2020-05-29
The clinical benefits of Chinese patent medicines against COVID-19 based on current evidence. Given this, based on the Guideline on Diagnosis and Treatment of Coronavirus Disease 2019 in China, the present review summarized the basic information, clinical evidence and published literatures of recommended CPMs against COVID-19. 2020-05-30
What dentists need to know about COVID-19. Given that COVID-19 has lately been detected in infected patients’ saliva, the COVID-19 outbreak is an alert that all dental and other health professionals must be vigilant in defending against the infectious disease spread, and it may enable to assess whether non-invasive saliva diagnostic for COVID-19. 2020-05-20
Endocrinology in the time of COVID-19: Management of Cushing’s syndrome. • Clinical evaluation should guide those needing investigation • Strict adherence to COVID-19 protection measures is necessary • Alternative ways of consultations (telephone, video) should be used • Early discussion with regional/national experts about investigation and management of potential and existing patients is strongly encouraged • Patients with moderate and severe clinical features need urgent investigation and management • Patients with active Cushing’s syndrome, especially when severe, are immunocompromised and social shielding is recommended • In patients with mild features or in whom a diagnosis is less likely, clinical re-evaluation should be repeated at three and six months or deferred until the prevalence of SARS-CoV-2 has significantly decreased • Diagnostic pathways may need to be very different from usual recommendations in order to reduce investigations • When extensive differential diagnostic testing is not feasible, it should be deferred, and medical treatment should be initiated • Transsphenoidal pituitary surgery may be avoided during high SARS-CoV-2 viral prevalence • Medical management rather than surgery will be the used for most patients since the short- to mid-term prognosis depends in most cases on hypercortisolism rather than its cause; it should be initiated promptly to minimize the risk of infection in these immunosuppressed patients. 2020-05-08
Canadian Society of Thoracic Radiology/Canadian Association of Radiologists Consensus Statement Regarding Chest Imaging in Suspected and Confirmed COVID-19. " This article also provides recommended reporting structure for CXR and CT, breaking diagnostic possibilities for both CXR and CT into 3 categories: typical, nonspecific, and negative based on imaging findings with representative images provided. 2020-05-18
Lack of cross-neutralization by SARS patient sera towards SARS-CoV-2. These findings will be of significant use in guiding the development of serologic tests, formulating convalescent plasma therapy strategies, and assessing the longevity of protective immunity for SARS-related coronaviruses in general as well as vaccine efficacy. 2020-05-11
CT differential diagnosis of COVID-19 and non-COVID-19 in symptomatic suspects: a practical scoring method. Hence, it is difficult to make an exclusive diagnosis. […] The clinical data including age, sex, exposure history, laboratory parameters and aetiological diagnosis of all patients were collected. […] With a simple and practical scoring system based on CT imaging features, we can make a hierarchical diagnosis of COVID-19 and non-COVID-19 with different management suggestions. 2020-05-11
The COVID-19 infection control arms race. Here, we review the factors underlying this arms race, including fears about personal safety, ongoing uncertainty around how SARS-CoV-2 is transmitted, confusion about what constitutes an aerosol-generating procedure, increasing recognition of the importance of asymptomatic infection, and the limited accuracy of diagnostic tests. 2020-05-22
Nosocomial infection with SARS-Cov-2 within Departments of Digestive Surgery. The median time from admission to diagnosis of SARS-Cov-2 infection was 34 days (5-61 days). […] In 12 patients (80%), the diagnosis was made after a hospital stay of more than 14 days (15-63 days). 2020-05-11
Cutaneous manifestations of COVID-19: Report of three cases and a review of literature. Skin lesion development occurred before the onset of respiratory symptoms or COVID-19 diagnosis in 12.5% (9/72) of the patients, and lesions spontaneously healed in all patients within 10 days. […] Infection with COVID-19 may result in dermatological manifestations with various clinical presentations, which may aid in the timely diagnosis of this infection. 2020-05-11
Performance Characteristics of the Abbott Architect SARS-CoV-2 IgG Assay and Seroprevalence in Boise, Idaho. The rollout of diagnostic testing in the United States was slow, leading to numerous cases that were not tested for SARS-CoV-2 in February and March 2020, necessitating the use of serological testing to determine past infections. 2020-05-08
Understanding, verifying and implementing Emergency Use Authorization molecular diagnostics for the detection of SARS-CoV-2 RNA. The SARS-CoV-2 pandemic has brought a new wave of challenges to health care, particularly in the area of rapid diagnostic test development and implementation. […] Acute diagnosis of COVID-19 infection is critically dependent on detection of SARS-CoV-2 RNA from clinical specimens (e.g. nasopharyngeal swabs). […] While laboratory-developed testing for SARS-CoV-2 is an essential component of diagnostic testing for this virus, the majority of clinical microbiology laboratories are dependent on commercially available SARS-CoV-2 molecular assays. […] In contrast to assays approved or cleared by the Food and Drug Administration for in vitro diagnostic use, assays for the detection of SARS-CoV-2 nucleic acids have Emergency Use Authorization (EUA) from the FDA. 2020-05-08
Comparison of Two High-Throughput Reverse Transcription-Polymerase Chain Reaction Systems for the Detection of Severe Acute Respiratory Syndrome Coronavirus 2. We analyzed the diagnostic performance of two high-throughput systems: cobas 6800 and Panther Fusion, and their associated RT-PCR assays with a collection of 389 nasopharyngeal specimens. 2020-05-08
Implementation of Clinical Diagnostic Criteria and Universal Symptom Survey Contributed to Lower Magnitude and Faster Resolution of the COVID-19 Epidemic in Wuhan. The SEIR+Q dynamics model was fitted using the daily reported number of confirmed infections and unconfirmed cases by clinical diagnostic criteria up to February 14, 2020 in Wuhan. […] Effective reproductive number R(t) analysis using observed frequencies showed a remarkable decline after the implementation of clinical diagnostic criteria and universal symptom surveys, which was significantly below the R(t) curve estimated by the model assuming that the pre-February 14 trend was carried forward. […] The implementation of clinical diagnostic criteria and universal symptom surveys contributed to a contraction in both the magnitude and the duration of the epidemic in Wuhan. 2020-05-11
Rhabdomyolysis as a Presentation of 2019 Novel Coronavirus Disease. Prompt diagnosis of the case is required to improve patients’ prognosis and control of the outbreak. […] However, patients may present with atypical symptoms that pose a diagnostic challenge. 2020-05-11
A Peptide-based Magnetic Chemiluminescence Enzyme Immunoassay for Serological Diagnosis of Coronavirus Disease 2019 (COVID-19). Therefore, combining our immunoassay with real-time RT-PCR might enhance the diagnostic accuracy of COVID-19. 2020-05-29
Clinical characteristics of patients with COVID-19 in Japan: a single-center case series. It would be difficult to triage patients with COVID-19 based on the typical symptoms of fever and/or cough, although PCR and CT are definitive in diagnosis. 2020-05-29
Should RT-PCR be considered a gold standard in the diagnosis of Covid-19? To face the new Covid-19 pandemic, the need for early and accurate diagnosis of the disease among suspected cases quickly became obvious for effective management, and for better control of the spread of the disease in the population. […] Since the beginning of this disease epidemic caused by the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), reverse transcriptase polymerase chain reaction (RT-PCR) has routinely been used to confirm diagnosis. 2020-05-08
Evaluation of SARS-CoV-2 neutralizing antibodies using a CPE-based colorimetric live virus micro-neutralization assay in human serum samples. Since the SARS-CoV-2 outbreak at the end of December 2019 in China, it has become extremely important to have well-established and validated diagnostic and serological assays for this new emerging virus. 2020-05-18
Prevalence and Duration of Acute Loss of Smell or Taste in COVID-19 Patients. To determine the prevalence of these symptoms and to evaluate their diagnostic significance, we (approximately 150 physicians of the Daegu Medical Association) prospectively collected data of cases of anosmia and ageusia from March 8, 2020, via telephone interview among 3,191 patients in Daegu, Korea. […] Anosmia and ageusia seem to be part of important symptoms and clues for the diagnosis of COVID-19, particularly in the early stage of the disease. 2020-05-13
Prolonged Persistence of SARS-CoV-2 RNA in Body Fluids. The prolonged persistence of virus RNA in various body fluids may guide the clinical diagnosis and prevention of onward virus transmission. 2020-05-08
A Unique Presentation of Delirium in a Patient with Otherwise Asymptomatic COVID-19. The patient’s positive test led to a diagnosis of COVID-19. […] The recognition of atypical presentations of COVID-19 infection, such as delirium, is critical to the timely diagnosis, provision of appropriate care, and avoidance of outbreaks within healthcare facilities during this pandemic. 2020-05-16
SARS-CoV-2 Pandemic: Review of the Literature and Proposal for Safe Autopsy Practice. To contain the infection risk, a revision of all the protocols that until now have been applied to the examination of bodies that require autopsy services is required. Data source: Currently, the diagnosis and postmortem analysis of positive or suspected COVID-19 cases plays a crucial role in scientific research. […] Scientific papers currently available via the PubMed NCBI search engine on COVID-19 postmortem diagnosis were also examined. Discussion: Throughout the history of medicine, the role of autopsy has been fundamental to the understanding of multiple pathogenic processes that are investigated postmortem through autopsy. 2020-05-08
COVID-19 on the Chest Radiograph: A Multi-Reader Evaluation of an AI System. Diagnostic performance was performed by receiver operating characteristic curve analysis. 2020-05-08
Rapid detection of SARS-CoV-2 by low volume real-time single tube reverse transcription recombinase polymerase amplification using an exo probe with an internally linked quencher (exo-IQ). The developed RT-RPA assay produced 100% diagnostic sensitivity and specificity when compared to RT-qPCR (n=20). 2020-05-29
What will be the new normal for the dental industry? From a dental industry perspective, equipment and product manufacturers and suppliers are building upon, and further developing, the industry’s extremely close relationship and partnership with the dental profession, in order to develop and implement new ways of thinking and new approaches, products and techniques to protect patients and clinicians, focusing on a return to the more widespread provision of dentistry. 2020-05-13
Clinical and radiological changes of hospitalised patients with COVID-19 pneumonia from disease onset to acute exacerbation: a multicentre paired cohort study. We reviewed clinical histories of 276 patients with confirmed COVID-19 pneumonia and extracted data on patients who met the diagnostic criteria for COVID-19 severe/fatal pneumonia and had an acute exacerbation starting with mild or common pneumonia. 2020-05-14
Diagnostic role of chest computed tomography in coronavirus disease 2019. The laboratory diagnosis of SARS-CoV-2 infection is currently based on real-time reverse transcriptase-polymerase chain reaction (RT-PCR) testing, and imaging cannot replace genetic testing in patients suspected of COVID-19. […] The role of chest CT as a diagnostic tool may be increased when the laboratory testing capacities using RT-PCR prove inaccurate or insufficient during a major outbreak of the disease. […] In these settings, a rapid presumptive diagnosis of COVID-19 potentially offered by CT might be an advantage, in addition to obvious benefits of delineating the nature and extent of pulmonary changes. […] In the present paper, we reviewed the diagnostic role of chest CT in COVID-19 patients. 2020-05-09
[Chinese experts’ consensus on diagnosis and treatment of severe and critical coronavirus disease 2019 (revised edition)]. In order to reduce the mortality of severe and critical COVID-19, experts from the first-line in related fields in China were organized to analyze, discuss and summarize the diagnosis and treatment of severe and critical COVID-19 patients in Wuhan and other severe epidemic areas, and formulate the expert consensus. 2020-05-12
[Visualization analysis on treatment of coronavirus based on knowledge graph]. In the subject words breakthrough analysis, there were time-related breakthrough points in 1991, 1996 and 2002, and the “diagnosis” and “sequence” were continuous hot spots. 2020-05-12
Imaging examination, diagnosis, and control and prevention of nosocomial infection for coronavirus disease 2019: Expert consensus of Hunan radiologist. Chest imaging examination is an important auxiliary examination method in diagnosis of COVID-19. […] To further standardize the imaging examination and diagnosis of COVID-19, Hunan Society of Radiology together with Imaging Technology Professional Committee of Hunan Medical Association reach an expert consensus document on imaging examination, diagnosis, and control and prevention of nosocomial infection for COVID-19. 2020-05-13
Design, validation, and clinical practice of standardized imaging diagnostic report for COVID-19. To design a standardized imaging diagnostic reporting mode for screening coronavirus disease 2019 (COVID-19), and to prospectively verify its effectiveness in clinical practice. […] A new classification and standardized imaging diagnosis report mode of viral pneumonia was established by studying and summarizing the imaging findings of various kinds of viral pneumonia, combining with lesion density, interstitial changes, pleural effusion, lymph nodes, and some special signs. […] The confirmed cases were verified, and the diagnostic efficacy of the standardized imaging reporting system in screening COVID-19 was tested. […] In combination with the above signs, the diagnostic efficacy of COVID-19 was 0.942. […] The standardized imaging diagnosis report mode based on COVID-19 chest image features is effective and practical, which should be popularized. 目的: 设计筛查2019冠状病毒病(coronavirus disease 2019,COVID-19)的规范化影像学诊断报告模式,并在临床实践中前瞻性验证其有效性。 2020-05-13
CT imaging features and image evolution characteristics of coronavirus disease 2019. These characteristics are of great value in assisting clinical diagnosis and dynamically observing changes undersuch condition. 目的: 分析2019冠状病毒病不同时期的影像学表现特点,并总结其演变特征。 2020-05-13
Multistage CT features of coronavirus disease 2019. To determine imaging features of coronavirus disease 2019 (COVID-19) in different stages, and to provide foundations for early diagnosis and treatment. […] Repeat CT examination plays an important role in the early clinical diagnosis and the evaluation for the therapeutic effect on COVID-19 patient. 目的: 通过多阶段观察2019冠状病毒病(coronavirus disease 2019,COVID-19)患者的CT影像学表现,研究COVID-19各期CT影像学特征,为临床早期诊断和治疗提供依据。 2020-05-13
Clinical and CT imaging features between the first nucleic acid-negative and first nucleic acid-positive COVID-19 patients. To investigate the role of chest CT for the diagnostic work-up for patients with suspected infection of coronavirus disease 2019 (COVID-19). […] Compared with the first nucleic acid-positive patients, the onset time of the first nucleic acid-negative patients was shorter [(3.58±2.94) d], but the diagnosis was longer [(3.92±3.66) d]. […] Chest CT examination is important to avoid COVID-19 missed diagnosis due to false negative nucleic acid. 目的: 探讨肺部CT在2019冠状病毒病(coronavirus disease 2019,COVID-19)临床筛查及早期诊断过程中的作用。 2020-05-13
First CT characteristic appearance of patients with coronavirus disease 2019. To investigate imaging features of the coronavirus disease 2019 (COVID-19), and to provide concrete evidences for diagnosis of COVID-19. […] The combination of the first chest CT imaging features and SARS-CoV-2 nucleic acid test results as well as reexamination if necessary can help to make the diagnosis of SARS-CoV-2 infection accurately. 目的: 分析2019冠状病毒病(coronavirus disease 2019,COVID-19)患者的首次胸部CT影像学表现,为COVID-19的及时诊断提供可靠依据。 2020-05-13
Value of CT application in the screening,diagnosis,and treatment of COVID-19. Early screening, early diagnosis, early isolation, and early treatment remain the most effective prevention and control measures. […] Computed tomography (CT) plays a vital role in the screening, diagnosis, treatment, and follow-up of COVID-19, especially in the early screening, with a higher sensitivity than that of real-time fluorescence RT-PCR. […] The combination of CT and artificial intelligence has the potential to help clinicians in improving the diagnostic accuracy and working efficiency. 2020-05-13
A family outbreak of coronavirus disease 2019. We reported a group of family cluster outbreak cases confirmed in Xiangya Hospital, Central South University, China, and their clinical and image characteristics have been analyzed in order to provide reference for the prevention and early diagnosis of this disease. 2020-05-13
Unprecedented action has been taken to contain the epidemic of coronavirus disease 2019 in China. Significant improvement regarding the pathogenesis, epidemiology, and diagnosis and therapy for the COVID-19 has been achieved to stop the spread of the epidemics. 2020-05-13
Diagnosis of Coronavirus Disease 2019 (COVID-19) with Structured Latent Multi-View Representation Learning. Due to the large number of infected patients and heavy labor for doctors, computer-aided diagnosis with machine learning algorithm is urgently needed, and could largely reduce the efforts of clinicians and accelerate the diagnosis process. […] Chest computed tomography (CT) has been recognized as an informative tool for diagnosis of the disease. […] In this study, we propose to conduct the diagnosis of COVID-19 with a series of features extracted from CT images. 2020-05-14
Urticarial eruption in Coronavirus Disease 2019 (COVID-19) infection: a case report in Tangerang, Indonesia. 2)(1)(3)(4) This atypical symptom might lead to misdiagnosis, delayed diagnosis, and virus transmission, especially in countries where cutaneous manifestation of COVID-19 has not been reported widely such as in Indonesia. 2020-05-09
Interventions for treatment of COVID-19: a protocol for a living systematic review with network meta-analysis including individual patient data (The LIVING Project). We will include randomized clinical trials comparing any intervention for the treatment of COVID-19 (e.g., pharmacological interventions, fluid therapy, invasive or noninvasive ventilation, or similar interventions) with any comparator (e.g., an “active” comparator, standard care, placebo, no intervention, or “active placebo”) for participants in all age groups with a diagnosis of COVID-19. 2020-05-13
SARS-CoV-2 infection may result in appendicular syndrome: Chest CT scan before appendectomy. An abdominal CT scan ruled out a diagnosis of appendicitis and a chest CT scan yielded a diagnosis of SARS-CoV-2 infection. 2020-05-14
Recognizing COVID-19-related myocarditis: the possible pathophysiology and proposed guideline for diagnosis and management. COVID-19 myocarditis diagnosis should be guided by insights from previous coronavirus and other myocarditis experience. […] Where the diagnosis remains uncertain, an endomyocardial biopsy may help identify active cardiac infection through viral genome amplification and possibly refine the treatment risks of systemic immunosuppression. 2020-05-14
Current development of COVID-19 diagnostics, vaccines and therapeutics. In this review, we describe some currently applied diagnostic approaches, as well as therapeutics and vaccines, to prevent, treat and control further outbreaks of SARS-CoV-2 infection. 2020-05-16
Study of combining virtual screening and antiviral treatments of the Sars-CoV-2 (Covid-19). It is anticipated that this will assist researchers and clinicians in developing better techniques for timely and effective detection of coronavirus infection. 2020-05-31
Early treatment of COVID-19 patients with hydroxychloroquine and azithromycin: A retrospective analysis of 1061 cases in Marseille, France. Prolonged viral carriage was observed in 47 patients (4.4%) and was associated to a higher viral load at diagnosis (p < .001) but viral culture was negative at day 10. 2020-05-16
Androgen-deprivation therapies for prostate cancer and risk of infection by SARS-CoV-2: a population-based study (n=4532). The parameters used for each COVID-19 positive patient were gender, hospitalization, admission to intensive care unit (ICU), death, tumor diagnosis, prostate cancer diagnosis, and androgen-deprivation therapy (ADT). 2020-05-14
Neurological Impact of Coronavirus Disease of 2019: Practical Considerations for the Neuroscience Community. Necessary adaptations in patient management, triage, and diagnosis are evolving in light of the ongoing scientific and clinical findings. 2020-05-31
COVID-19 challenges to Pakistan: Is GIS analysis useful to draw solutions? With the increased availability of electronic health-care data and spatial analysis techniques, there is great potential to develop algorithms to enable more effective disease surveillance. […] However, GIS techniques, resources, and methods can be used in Pakistan for more effective investigation of vulnerable geographical locations. 2020-05-31
Clinical evaluation of an immunochromatographic IgM/IgG antibody assay and chest computed tomography for the diagnosis of COVID-19. We evaluated the clinical performance of an immunochromatographic (IC) IgM/IgG antibody assay for severe acute respiratory syndrome coronavirus 2 (SARS-CoV2) and chest computed tomography (CT) for the diagnosis of Coronavirus disease 2019 (COVID-19). […] The diagnostic sensitivity of CT scan alone and in combination with the IC assay was 57.9 % (22/38) and 68.4 % (26/38) for the asymptomatic patients and 74.3 % (55/74) and 82.4 % (61/74) for the symptomatic patients, respectively. […] The IC assay had low sensitivity during the early phase of infection, and thus IC assay alone is not recommended for initial diagnostic testing for COVID-19. 2020-05-29
Operative team checklist for aerosol generating procedures to minimise exposure of healthcare workers to SARS-CoV-2. The example of paediatric laryngo-bronchoscopy for diagnostic purposes or retrieval of an inhaled airway foreign body is used to illustrate the steps however the checklist structure is modifiable for other AGP and adaptable for local needs. 2020-05-19
Rapid and sensitive detection of SARS-CoV-2 RNA using the Simplexa™ COVID-19 direct assay. So far, one of the major drawbacks of the available molecular assays for the diagnosis of severe acute respiratory syndrome Coronavirus-2 (SARS-CoV-2) is the need for viral nucleic acid extraction from clinical specimens. […] The high sensitivity and specificity of this new assay indicate that it is promising for laboratory diagnosis, enabling highspeed detection in just over one hour, which is significantly faster than the up to five hours currently required by traditional extraction followed by amplification technologies, thus allowing prompt decision making regarding isolation of infected patients. 2020-05-29
Clinical evaluation of a SARS-CoV-2 RT-PCR assay on a fully automated system for rapid on-demand testing in the hospital setting. The ongoing SARS-CoV-2 pandemic presents a unique challenge for diagnostic laboratories around the world. 2020-05-29
The implications of preliminary screening and diagnosis: Clinical characteristics of 33 mild patients with SARS-CoV-2 infection in Hunan, China. Reduced whole blood lymph count can be used as an adjuvant diagnosis of early SARS-CoV-2 infection. 2020-05-29
Reactive psychoses in the context of the COVID-19 pandemic: Clinical perspectives from a case series. In that short period, four patients met the Diagnostic and Statistical Manual of Mental Disorders (DSM-5) criteria for a brief reactive psychotic disorder. […] This type of psychosis has a high risk of suicidal behavior and, although short-lived, has a high rate of psychotic recurrence and low diagnostic stability over time. 2020-05-14
SARS-CoV-2 infection in patients on renal replacement therapy. Report of the COVID-19 Registry of the Spanish Society of Nephrology (SEN). It collects epidemiological variables, contagion and diagnosis data, signs and symptoms, treatments and outcomes. 2020-05-14
The potential impact of COVID-19 on psychosis: A rapid review of contemporary epidemic and pandemic research. Psychosis diagnosis was associated with viral exposure, treatments used to manage the infection, and psychosocial stress. 2020-05-15
Dynamic profile for the detection of anti-SARS-CoV-2 antibodies using four immunochromatographic assays. In order to fight the SARS-CoV-2 pandemic infection, there is a growing need and demand for diagnostic tools that are complementary and different from the RT-PCR currently in use. […] Thus, immunochromatographic tests for the detection of anti-SARS-CoV-2 antibodies may have their place for the diagnostic panel of COVID-19. 2020-05-19
Cutaneous signs in COVID-19 patients: A review. Knowledge of the cutaneous manifestations of COVID-19 may help in early diagnosis, triage of patients, and risk stratification. 2020-05-30
Urologic surgery and invasive procedures during coronavirus pandemic: Retrospective comparison of risk infection in a referral Covid hospital and in a free-Covid hospital. At the Covid-19 hospital, 12 patients underwent surgery and 51 patients invasive diagnostic procedures between 22 February and 8 March 2020; in the same period, at the Covid-19-free hospital, 21 patients underwent surgery and 56 patients invasive diagnostic procedures. 2020-05-11
On the brighter side of COVID-19 induced Lockdown: Devising the collateral methods to provide Ayurveda consultation during impasse. Telemedicine had been an ideal option for such situations allowing all channels of communication that leverage Information Technology platforms, including voice, audio, text and digital data exchange as a help to diagnosis, prescription and follow up evaluation. 2020-05-15
A Hemodialysis Patient with Severe COVID-19 Pneumonia. We describe the clinical presentation of this patient, the diagnostic process, the laboratory and imaging investigations, as well as the course of treatment. 2020-05-15
A Precision Medicine Approach to SARS-CoV-2 Pandemic Management. Precision medicine (PM) represents a new paradigm in disease diagnosis, prevention, and treatment. […] Better understanding of pathogenic pathways together with an accurate phenotype classification of patients presented with SARS-CoV-2 infection and symptoms might contribute to a more accurate definition of biomarkers and other diagnostic tools, which may lead to more precise mitigation strategies, personalized pharmacologic options, as well as new biological therapy developments. 2020-05-15
Use of Corticosteroids in Coronavirus Disease 2019 Pneumonia: A Systematic Review of the Literature. Patients with a validated diagnosis of COVID-19 and using corticosteroids were included, considering all health outcomes. 2020-05-15
Survey data of COVID-19-related Knowledge, Risk Perceptions and Precautionary Behavior among Nigerians. A combination of purposive and snowball techniques helped to select the respondents via Whatsapp and Facebook from 180 cities/towns in the 6 geopolitical zones of Nigeria. 2020-05-30
Detection of SARS-COV-2 in Placental and Fetal Membrane Samples. Maternal COVID-19 illness was categorized as mild, severe, or critical.4 The time interval from maternal diagnosis of COVID-19 to delivery was calculated in days. 2020-05-11
[Diagnosis and treatment recommendation for pediatric COVID-19 (the second edition)]. The diagnosis of COVID-19 is largely based on the epidemiological evidence and clinical manifestations, and confirmed by positive detection of virus nucleic acid in respiratory samples. […] Early identification, early isolation, early diagnosis and early treatment are important for clinical management. 2020-05-12
[Management of COVID-19: the Zhejiang experience]. However, since COVID-19 was a newly emerging disease, more work was warranted to improve strategies of prevention, diagnosis and treatment for COVID-19. 2020-05-12
[Pharmaceutical care for severe and critically ill patients with COVID-19]. Based on Diagnosis and treatment of novel coronavirus pneumonia (trial version 6), and Management of COVID-19: the Zhejiang experience, we summarized the experience in the use of antiviral drugs, corticosteroids, vascular active drugs, antibacterial, probiotics, nutrition support schemes in severe and critically ill COVID-19 patients. 2020-05-12
[Diagnostic efficacy of three test kits for SARS-CoV-2 nucleic acid detection]. To compare the diagnostic efficacy among three RT-PCR test kits for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) nucleic acid detection. 2020-05-12
[CT imaging features of patients with different clinical types of COVID-19]. A total of 67 patients diagnosed as COVID-19 by nucleic acid testing were collected and divided into 4 groups according to the clinical stages based on Diagnosis and treatment of novel coronavirus pneumonia (trial version 6). 2020-05-12
[Roles of multidisciplinary team in diagnosis and treatment of suspected cases of COVID-19]. To analyze the roles of multidisciplinary team (MDT) in the diagnosis and treatment of suspected cases of coronavirus disease 2019 (COVID-19). […] The efficiency of diagnosis and treatment for suspected COVID-19 patients can be improved with MDT, particularly for complicated cases. 2020-05-12
[Clinical experience of high-flow nasal cannula oxygen therapy in severe COVID-19 patients]. High-flow nasal cannula (HFNC) has been utilized widely due to its superiority over other non-invasive respiratory support techniques. 2020-05-12
[Respiratory complaints in the time of COVID-19]. The current guidelines for diagnosis and treatment of primary respiratory infections are still useful during the COVID-19 epidemic.Telephone triage of patients with respiratory complaints aims to identify patients with complications or an increased risk of complications.There are no indications to test for SARS-CoV-2 virus in general practice.During this COVID-19 epidemic, protective clothing is recommended in all physical contacts with patients with respiratory complaints.There is no reason to be cautious about using NSAIDs in patients suspected of COVID-19. 2020-05-20
Association of Treatment With Hydroxychloroquine or Azithromycin With In-Hospital Mortality in Patients With COVID-19 in New York State. Among 1438 hospitalized patients with a diagnosis of COVID-19 (858 [59.7%] male, median age, 63 years), those receiving hydroxychloroquine, azithromycin, or both were more likely than those not receiving either drug to have diabetes, respiratory rate >22/min, abnormal chest imaging findings, O2 saturation lower than 90%, and aspartate aminotransferase greater than 40 U/L. 2020-05-20
[Application of pulmonary ultrasound in the diagnosis of COVID-19 pneumonia in neonates]. Objective: To investigate the application of pulmonary ultrasound in the diagnosis of neonatal COVID-19. Methods: In this retrospective study, the clinical data of 5 infants, who were admitted to the Department of Neonatology in Wuhan Children’s Hospital from 31(st) January to 25(th) February 2020, were collected. […] The sensitivity of pulmonary ultrasound is higher than that of chest X-ray and CT in the diagnosis of pulmonary edema, and could be used in monitoring and evaluation of the disease. 目的: 探讨肺部超声在新生儿新型冠状病毒肺炎(COVID-19)诊断中的应用。 2020-05-13
COVID-19: animals, veterinary and zoonotic links. Best efforts are being taken up by worldwide nations to implement effective diagnosis, strict vigilance, heightened surveillance, and monitoring, along with adopting appropriate preventive and control strategies. 2020-05-27
Perceived infection transmission routes, infection control practices, psychosocial changes, and management of COVID-19 infected healthcare workers in a tertiary acute care hospital in Wuhan: a cross-sectional survey. The top three first symptoms displayed before diagnosis were fever (41.8%), lethargy (33.0%) and muscle aches (30.1%). […] After diagnosis, 88.3% staff experienced psychological stress or emotional changes during their isolation period, only 11.7% had almost no emotional changes. 2020-05-14
Intelligent classification of platelet aggregates by agonist type. The method then involved using high-throughput techniques to take thousands of images of these samples. […] But first more studies are needed to confirm whether this method is a useful tool for drug selection or diagnosis. 2020-05-14
Non-communicable disease management in vulnerable patients during Covid-19. Temporary closure of outpatient health facilities in some secondary and tertiary care hospitals have deprived millions of NCD patients of their regular medication and diagnostic health needs. 2020-05-14
Chest CT features of the novel coronavirus disease (COVID-19). Chest computed tomography (CT) plays an essential role in the diagnosis of viral pneumonia, monitoring disease progression, determination of disease severity, and evaluating therapeutic efficacy. […] Prompt diagnosis of COVID-19 is essential to prevent disease transmission and provide close clinical observation of patients with clinically severe disease. 2020-05-12
The development and initial tests for the psychometric properties of the COVID-19 Phobia Scale (C19P-S). The current study developed a self-report instrument whose items address the specific phobia diagnosis criteria of the DSM-V and tested its initial psychometric properties. 2020-05-15
Deep learning for detecting corona virus disease 2019 (COVID-19) on high-resolution computed tomography: a pilot study. To evaluate the diagnostic efficacy of Densely Connected Convolutional Networks (DenseNet) for detection of COVID-19 features on high resolution computed tomography (HRCT). […] Deep learning (DL) with DenseNet can accurately classify COVID-19 on HRCT with an AUC of 0.98, which can reduce the miss diagnosis rate (combined with radiologists’ evaluation) and radiologists’ workload. 2020-05-15
The challenges in colorectal cancer management during COVID-19 epidemic. The epidemic stage of COVID-19 has brought great challenges to the diagnosis and management of colorectal cancer (CRC) patients. 2020-05-15
2019 novel coronavirus pneumonia with onset of dizziness: a case report. The nucleic acid gene detection was positive, and thus the diagnosis of 2019-nCoV was confirmed. 2020-05-15
Clinical and Radiographic Presentations of COVID-19 among Patients Receiving Radiation Therapy for Thoracic Malignancies. Recent data support the diagnostic consistency and potential value of computed tomography (CT) scans to aid early diagnosis of COVID-19. 2020-05-15
SARS-CoV-2 infection virological diagnosis. SARS-CoV-2 infection has to be confirmed by virological diagnosis. […] Multiple diagnostic tests are available without enough perspective on their reliability. […] Currently, the RT-PCR detection of the viral genome in respiratory samples is the most reliable test to confirm the diagnosis of an acute SARS-CoV-2 infection. […] Detection of virus antigens on respiratory samples is a quick and easy to use technique; however it has not good specificity and sensitivity and cannot be used for diagnosis and patient management. […] Research should be encouraged to overcome the limits of the currently available diagnostic tests. 2020-05-13
Surgery during the COVID-19 pandemic: operating room suggestions from an international Delphi process. Consensus was reached on 71/100 statements, predominantly standardisation of OR pathways, OR staffing, and pre-operative screening or diagnosis. 2020-05-12
Recent progress on the diagnosis of 2019 Novel Coronavirus. Here, we review the types, characteristics and shortcomings of various detection methods, as well as perspectives for the SARS-CoV-2 diagnosis. 2020-05-31
[Atypical clinical picture of COVID-19 in older patients]. Protocols for diagnosis, and contact isolation measures, should take these atypical presentations into account. 2020-05-20
Deep Learning COVID-19 Features on CXR using Limited Training Data Sets. Under the global pandemic of COVID-19, the use of artificial intelligence to analyze chest X-ray (CXR) image for COVID-19 diagnosis and patient triage is becoming important. […] To address this problem, here we propose a patch-based convolutional neural network approach with a relatively small number of trainable parameters for COVID-19 diagnosis. […] Experimental results show that our method achieves state-of-the-art performance and provides clinically interpretable saliency maps, which are useful for COVID-19 diagnosis and patient triage. 2020-05-14
Wearable Sensing and Telehealth Technology with Potential Applications in the Coronavirus Pandemic. The article will focus specifically on 1) wearable devices suitable for monitoring the populations at risk and those in quarantine, both for evaluating the health status of caregivers and management personnel, and for facilitating triage processes for admission to hospitals; 2) unobtrusive sensing systems for detecting the disease and for monitoring patients with relatively mild symptoms whose clinical situation could suddenly worsen in improvised hospitals; and 3) telehealth technologies for the remote monitoring and diagnosis of COVID-19 and related diseases. 2020-05-14
Elective Tracheostomy During Mechanical Ventilation in Patients Affected by COVID-19: Preliminary Case Series From Lombardy, Italy. The procedure was performed with percutaneous (10 cases) and open (22 cases) surgical techniques. 2020-05-12
US CDC Real-Time Reverse Transcription PCR Panel for Detection of Severe Acute Respiratory Syndrome Coronavirus 2. In response, we developed a diagnostic panel consisting of 3 real-time reverse transcription PCR assays targeting the nucleocapsid gene and evaluated use of these assays for detecting SARS-CoV-2 infection. 2020-05-12
Identification of potential molecules against COVID-19 main protease through structure-guided virtual screening approach. Current approved drugs or molecules under clinical trials can be a good pool for repurposing through in-silico techniques to quickly identify promising drug candidates. 2020-05-30
Venous Thromboembolism Complicated with COVID-19: What Do We Know So Far? In this review, we discuss present knowledge of the topic, the unique challenges of diagnosis and treatment of VTE, as well as some of the potential mechanisms of increased risk for VTE during the illness. […] Understanding the true impact of VTE on patients with COVID-19 will potentially improve our ability to reach a timely diagnosis and initiate proper treatment, mitigating the risk for this susceptible population during a complicated disease. 2020-05-12
A Proposed Plan for Prenatal Care to Minimize Risks of COVID-19 to Patients and Providers: Focus on Hypertensive Disorders of Pregnancy. As the clinical management of gestational hypertension and preeclampsia is the same, assessment of urinary protein is unnecessary in the management once a diagnosis of a hypertensive disorder of pregnancy is made. 2020-05-12
The role of telemedicine in the delivery of healthcare in the COVID-19 Pandemic. The general response to the pandemic has included increased measures focused on personal hygiene, social distancing, symptom monitoring, early diagnosis, patient isolation, shelter in place, and public health quarantine. 2020-05-12
Nasopharyngeal and Oropharyngeal Swabs, And/Or Serology for SARS COVID-19: What Are We Looking For? In order to integrate the molecular assays in the diagnosis of SARS-CoV-2, a wide range of serology immunoassays (IAs) have also been developed. 2020-05-18
Tocilizumab for Treatment of Severe COVID-19 Patients: Preliminary Results from SMAtteo COvid19 REgistry (SMACORE). A retrospective analysis of patients treated with TCZ matched using propensity score to patients treated with Standard Of Care (SOC) was conducted. Setting: The study was conducted at IRCCS Policlinico San Matteo Hospital, Pavia, Italy, from March 14, 2020 to March 27, 2020. Participants: Patients with a confirmed diagnosis of COVID-19 hospitalized in our institution at the time of TCZ availability. Interventions: TCZ was administered to 21 patients. 2020-05-13
Saliva-Friend and Foe in the COVID-19 Outbreak. This review focuses on the role of saliva as both a foe (a common mode of viral transmission via salivary droplets and potentially aerosols) and a friend (as a non-invasive diagnostic tool for viral detection and immune status surveillance) in combating COVID-19. 2020-05-13
Using X-ray images and deep learning for automated detection of coronavirus disease. Medical images analysis is one of the most promising research areas, it provides facilities for diagnosis and making decisions of a number of diseases such as Coronavirus. 2020-05-30
Currently available intravenous immunoglobulin contains antibodies reacting against severe acute respiratory syndrome coronavirus 2 antigens. Aim: There is a critical need for effective therapies that are immediately available to control the spread of COVID-19 disease. Material & methods: Gamunex®-C and Flebogamma® DIF (Grifols) intravenous immunoglobulin (IVIG) products were tested using ELISA techniques for antibodies against several antigens of human common betacoronaviruses that may crossreact with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus. Results: Both IVIGs showed consistent reactivity to components of the tested viruses. 2020-05-16
The expression level of angiotensin-converting enzyme 2 determine the severity of COVID-19: lung and heart tissue as targets. Several studies have been performed in order to develop antiviral drugs, from which a few have been prescribed to patients in addition, several diagnostic tests have been designed to accelerate the process of identifying and treating COVID-19. 2020-05-13
Lung ultrasound in the monitoring of COVID-19 infection. The diagnosis of mild disease was made clinically which was later reaffirmed by LUS after identifying a bilateral small pleural effusion and a thickened pleural line. 2020-05-13
RNA genome conservation and secondary structure in SARS-CoV-2 and SARS-related viruses: a first look. These 59 ‘SARS-CoV-2-conserved-unstructured’ genomic regions may be most easily targeted in primer-based diagnostic and oligonucleotide-based therapeutic strategies. 2020-05-24
COVID-19: lessons to date from China. Screening of children who have a definitive contact history will facilitate early diagnosis and isolation of all infected children. 2020-05-13
Gaining resilience and reducing stress in the age of COVID-19. In this article, we will define the physiological, psychological and social aspects, stages, and components of stress reactions in the context of COVID-19, review the relevant literature on stress reactions, and offer some guidance on how to help patients mitigate the physiological and psychological impact of the pandemic through resilience-building techniques. 2020-05-13
Impact of COVID 19 lockdown on orthopaedic surgeons in India: A survey. The psychological impact of the lockdown during COVID 19 on orthopaedic surgeons may become a potential concern that will require addressal through open discussion. diagnostic level 4. 2020-05-16
Initial success in the identification and management of the coronavirus disease 2019 (COVID-19) indicates human-to-human transmission in Wuhan, China. We summarized epidemiology, virological characteristics, clinical symptoms, diagnostic methods, clinical treatments, and prevention methods for COVID-19 to present a reference for the future wave of probable CoV outbreaks. 2020-05-15
Takotsubo Syndrome Associated with COVID-19. The patient developed tachycardia and the echocardiogram confirmed the diagnosis of Takotsubo cardiomyopathy. 2020-05-16
Human coronaviruses with emphasis on the COVID-19 outbreak. By the 16-February 2020, total existing diagnosis cases of COVID-19, in china now numbered around 57,255, total cumulative diagnosis is about 68,592, total existing suspicion is about 8228, a total severe existing disease 11,272, the total cumulative cure is about 9671 with more than 1666 cumulative deaths have been reported. 2020-05-16
Computed tomography findings in a case of coronavirus disease 2019. The preferred imaging modality is chest computed tomography (CT) which plays an important role in early diagnosis, quarantine, and treatment as well as in the evaluation of therapeutic efficacy. […] Our aims are to improve understanding of this disease and to facilitate early diagnosis and evaluation of therapeutic efficacy. […] Throat swabs were positive for the SARS-CoV-2 nucleic acid, which confirmed the diagnosis of COVID-19. […] Chest CT plays a key role in the diagnosis of COVID-19, providing an accurate diagnosis and is a sensitive technique for evaluation of therapeutic efficacy. 2020-05-13
COVID-19: Are Africa’s diagnostic challenges blunting response effectiveness? Here, based on the African situation, we discuss COVID-19 diagnostic challenges and how they may blunt responses. 2020-05-16
A technical report from the Italian SARS-CoV-2 outbreak. Postmortem sampling and autopsy investigation in cases of suspected or probable COVID-19. The aim of the present report is to share a procedure applicable to cases of COVID-19-related death, particularly in cases of death without medical intervention and in the absence of an ascertained SARS-CoV-2 infection and/or COVID-19 diagnosis, therefore providing support for diagnostic activity in the present COVID-19 pandemic. 2020-05-16
Ethical considerations for allocation of scarce resources and alterations in surgical care during a pandemic. The resultant burden of disease and critical illness has outpaced the diagnostic, therapeutic, and health care professional resources of many clinics and hospitals. 2020-05-16
Impact of the Covid-19 outbreak on acute stroke pathways - Insights from the Alsace region in France. There were no significant differences in time delays or severity of clinical symptoms for patients treated by IVT or MT, nor in the distribution of final diagnosis among stroke alerts and stroke unit admissions. 2020-05-13
Invasive strategy for COVID patients presenting with acute coronary syndrome: The first multicenter Italian experience. PCI was performed in all cases expect two that were diagnosed as suspected myocarditis because of the absence of severe coronary disease and three with apical ballooning at ventriculography diagnostic for Tako-Tsubo syndromes. 2020-05-13
The COVID-19 pandemic: A rapid global response for children with cancer from SIOP, COG, SIOP-E, SIOP-PODC, IPSO, PROS, CCI, and St Jude Global. We provide some practical advice for adapting diagnostic and treatment protocols for children with cancer during the pandemic, the measures taken to contain it (e.g., extreme social distancing), and how to prepare for the anticipated recovery period. 2020-05-29
CRISPR-cas systems based molecular diagnostic tool for infectious diseases and emerging 2019 novel coronavirus (COVID-19) pneumonia. Accurate and rapid diagnostic tools are essential for early recognition and treatment of infectious diseases, allowing timely implementation of infection control, improved clinical care and other public health measures to stop the spread of the disease. […] In this review, we summarise current advance regarding diverse CRISPR-Cas systems, including CRISPR-Cas9, CRISPR-Cas12 and CRISPR-Cas13, in the development of fast, accurate and portable diagnostic tests and highlight the potential of CRISPR-Cas13 in COVID-19 Pneumonia and other emerging infectious diseases diagnosis. 2020-05-26
COVID-19 in Post-Operative Patients: Imaging Findings. Computed tomography provided an alternate diagnosis in 53% of patients who did not have COVID-19. […] Chest CT provides prompt diagnosis of COVID-19. 2020-05-13
Biological and social aspects of Coronavirus Disease 2019 (COVID-19) related to oral health. Currently, there is no effective treatment and fast diagnosis is still a challenge. 2020-05-19
Characteristics and Outcomes of Recipients of Heart Transplant With Coronavirus Disease 2019. Heart transplant and a confirmed diagnosis of COVID-19. […] Twenty-eight patients with HT received a confirmed diagnosis of COVID-19. 2020-05-20
Clinical Performance of Two SARS-CoV-2 Serologic Assays. Diagnostic sensitivity, specificity, and concordance were calculated. […] The Abbott SARS-CoV-2 assay had a diagnostic specificity of 99.4% (95% CI; 96.41-99.98%), and sensitivity of 0.0% (95% CI; 0.00-26.47%) at <3 days post symptom onset, 30.0% (95% CI; 11.89-54.28) at 3-7d, 47.8% (95% CI; 26.82-69.41) at 8-13d and 93.8% (95% CI; 82.80-98.69) at ≥14d. […] Diagnostic specificity on the EI assay was 94.8% (95% CI; 89.96-97.72) if borderline results were considered positive and 96.7% (95% CI; 92.54-98.93) if borderline results were considered negative. […] The diagnostic sensitivity was 0.0% (95% CI; 0.00-26.47%) at <3d, 25.0% (95% CI; 8.66-49.10) at 3-7d, 56.5% (95% CI; 34.49-76.81) at 3-7d and 85.4% (95% CI; 72.24-93.93) at ≥14d if borderline results were considered positive. […] However, diagnostic sensitivity was poor in both assays during the first 14 days of symptoms. 2020-05-29
Self-collection: An appropriate alternative during the SARS-CoV-2 pandemic. Self-collection of nasal and throat swabs offers a reliable alternative to health worker collection for the diagnosis of SARS-CoV-2 and other respiratory viruses and provides patients with easier access to testing, reduces exposure of the community and health workers to those being tested and reduces requirement for PPE. 2020-05-31
A RT-PCR assay for the detection of coronaviruses from four genera. To design and evaluate a molecular diagnostic tool for detection and identification of all currently recognized and potentially future emergent CoVs from the Orthocoronavirinae subfamily. 2020-05-29
[COVID-19 associated pneumonia despite repeatedly negative PCR-analysis from oropharyngeal swabs]. Pulmonary auscultation showed basal soft crackling noises of the left lung FINDINGS AND DIAGNOSIS: Laboratory examination showed increased values for LDH, pro-BNP and CRP and normal values for leucocytes and procalcitonin. […] After a third attempt for a PCR-analysis of a deep oral swab-sample was negative, analysis of a sputum was performed which finally confirmed the diagnosis of COVID-19 associated pneumonia. […] Due to clinical recovery antiviral therapy was not performed after confirming the diagnosis. […] Finally, PCR-analysis of sputum confirmed the diagnosis. 2020-05-13
SWAB team instead of SWAT team - students as front-line force during the COVID-19 Pandemic. Therefore, front-line operations, such as emergency departments (ED), were highly stressed by immediate demand for diagnostic swab-testing, and additional personnel were urgently needed within a short time. 2020-05-22
Colon capsule endoscopy: an innovative method for detecting colorectal pathology during the Covid-19 pandemic? Non-emergency endoscopic activity in the UK has been postponed, raising concerns of increased delays in the diagnosis of colorectal cancer and a surge in demand once services resume. 2020-05-13
Safe performance of diagnostic bronchoscopy/EBUS during the SARS-CoV-2 pandemic. This commentary addresses the key paired issues of minimizing performance of diagnostic/staging bronchoscopy in patients with suspected/known lung cancer while maximizing the safety of the procedure with respect to HCW transmission of COVID-19. 2020-05-13
EAPCI Position Statement on Invasive Management of Acute Coronary Syndromes during the COVID-19 pandemic. Modified diagnostic and treatment algorithms are proposed to adapt evidence-based protocols for this unprecedented challenge. 2020-05-14
Towards effective diagnostic assays for COVID-19: a review. By mid-January 2020, a scientist from China published the full genome of the virus, which facilitated the development of accurate molecular diagnostic assays. 2020-05-14
Large-scale, in-house production of viral transport media to support SARS-CoV-2 PCR testing in a multi-hospital healthcare network during the COVID-19 pandemic. In response to this ongoing shortage, we began production of VTM in-house in support of diagnostic testing in our hospital network. […] As our diagnostic laboratory was not equipped for reagent production, we took advantage of space and personnel that became available due to closure of the research division of our medical center. 2020-05-20
Bacteremia and Blood Culture Utilization During COVID-19 Surge in New York City. We sought to evaluate the utilization and diagnostic yield of blood cultures during the COVID-19 pandemic to determine prevalence and common etiologies of bacteremia, and to inform a diagnostic approach to relieve blood culture overutilization. 2020-05-14
FIRST CASE OF CORONAVIRUS DISEASE 2019 IN CHILDHOOD LEUKEMIA IN CHINA. The patient showed a prolonged manifestation of symptoms and a protracted diagnosis period of COVID-19. 2020-05-14
Clinical Analysis of 25 Novel Coronavirus Infections in Children. The diagnosis was confirmed through RNA-PCR testing. […] RNA-PCR test is still the most reliable diagnostic method, especially for asymptomatic patients. 2020-05-14
Diagnostic Performance of Chest X-Ray for COVID-19 Pneumonia During the SARS-CoV-2 Pandemic in Lombardy, Italy. We assessed the diagnostic performance of CXR in consecutive patients presenting at the emergency room at the Policlinico San Donato, Milan, Italy from February 24 to April 8, 2020 for suspected SARS-CoV-2 infection. 2020-05-14
Chest Computed Tomography Manifestation of Coronavirus Disease 2019 (COVID-19) in Patients With Cardiothoracic Conditions. Computed tomography (CT) has been suggested as a highly sensitive modality for the diagnosis of pulmonary involvement in the early stages of COVID-19. […] The diagnosis of COVID-19 on the basis of the imaging features may be more challenging in patients with preexisting cardiothoracic conditions, such as chronic obstructive pulmonary disease, interstitial lung disease, cardiovascular disease, and malignancies with cardiothoracic involvement. […] Thus, understanding the specific CT manifestations in these special subgroups is essential for a prompt diagnosis. 2020-05-14
Clinical features of coronavirus disease 2019 (COVID-19) in a cohort of patients with disability due to spinal cord injury. To describe the clinical and analytical features of a coronavirus disease 2019 (Covid-19) infected cohort with SCI to enable accurate diagnosis and to outline prevention measures. […] Diagnosis was confirmed with reverse transcriptase polymerase chain reaction (RT-PCR) of nasal exudate or sputum samples. […] The average delay for diagnostic confirmation was 4 days (interquartile range, 1-10). […] All but one patient showed radiological alterations evident in chest X-rays at the time of diagnosis. 2020-05-19
Continuing versus suspending angiotensin-converting enzyme inhibitors and angiotensin receptor blockers: Impact on adverse outcomes in hospitalized patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Eligible patients using renin-angiotensin system blockers (ACEI/ARBs) with a confirmed diagnosis of COVID-19 will be randomized to a strategy of continued ACEI/ARB treatment versus temporary discontinuation for 30 days. 2020-05-16
Dynamic changes in routine blood parameters of a severe COVID-19 case. Novel coronavirus infectious disease (COVID-19) has been spreading worldwide, and tracking laboratory indexes during the diagnosis and treatment of patients with severe COVID-19 can provide a reference for patients in other countries and regions. […] We closely tracked the epidemiological history, diagnosis and treatment process, as well as dynamic changes in routine blood indicators, of a severe COVID-19 patient who was hospitalized for 26 days. 2020-05-31
Decreased T cell populations contribute to the increased severity of COVID-19. Monitoring T cell changes has important implications for the diagnosis and treatment of severe patients who may become critically ill. 2020-05-31
Point-of-care (POC) lung ultrasound in intensive care during the COVID-19 pandemic. The present analytical paper on the role of point-of-care lung ultrasound in this pandemic examines its diagnostic accuracy, clinical utility, and physical practicality in the intensive care unit. 2020-05-14
Incidence of asymptomatic deep vein thrombosis in patients with COVID-19 pneumonia and elevated D-dimer levels. In this prospective study consecutive patients hospitalized in non-intensive care units with diagnosis of COVID-19 pneumonia and D-dimer > 1000 ng/ml were screened for asymptomatic DVT with complete compression doppler ultrasound (CCUS). […] Higher cut-off levels for D-dimer might be necessary for the diagnosis of DVT in COVID-19 patients. 2020-05-29
Reductions in Heart Failure Hospitalizations During the COVID-19 Pandemic. Prior to the COVID-19 pandemic in our medical center, a mean of 30 patients per week were admitted with a principal diagnosis of HF. 2020-05-16
Comparative review of respiratory diseases caused by coronaviruses and influenza A viruses during epidemic season. This is a discussion and comparison of the virus structures, transmission characteristics, clinical symptoms, diagnosis, pathological changes, treatment and prevention of the two kinds of viruses, CoVs and IAVs. 2020-05-23
Comparison of Cepheid Xpert Xpress and Abbott ID Now to Roche cobas for the Rapid Detection of SARS-CoV-2. The SARS-CoV-2 pandemic has created an urgent and unprecedented need for rapid large-scale diagnostic testing to inform timely patient management. 2020-05-19
Real-time PCR-based SARS-CoV-2 detection in Canadian laboratories. With emergence of pandemic COVID-19, rapid and accurate diagnostic testing is essential. 2020-05-26
How to carry out and interpret EEG recordings in COVID-19 patients in ICU? However, EEG technologists should not be put in danger if obtaining an EEG does not significantly advance diagnosis or change management in the patient. 2020-05-14
Detection of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Is Comparable in Clinical Samples Preserved in Saline or Viral Transport Medium. As the coronavirus disease 2019 (COVID-19) pandemic sweeps across the world, the availability of viral transport medium (VTM) has become severely limited, contributing to delays in diagnosis and rationing of diagnostic testing. […] Use of PBS as a transport medium has the potential to increase testing capacity for SARS-CoV-2, aiding more widespread screening and early diagnosis of COVID-19. 2020-05-30
B-cell depleting therapies may affect susceptibility to acute respiratory illness among patients with multiple sclerosis during the early COVID-19 epidemic in Iran. Collected data included the current MS DMT and patient-reported disability level, history of recent sick contact, recent fever, respiratory symptoms, diagnosis with COVID-19, and the disposition after the diagnosis. […] We defined a COVID-19-suspect group as patients having fever and cough or fever and shortness of breath, or a presumptive diagnosis based on suggestive chest computed tomography. 2020-05-27
The Efficacy and Safety of Fecal Microbiota Transplant for Recurrent Clostridiumdifficile Infection: Current Understanding and Gap Analysis. We discuss the current knowledge gaps driven by questions around the quality and consistency of clinical trial results, patient selection, diagnostic methodologies, use of suppressive antibiotic therapy, and methods for adverse event reporting. 2020-05-14
Manifestations and prognosis of gastrointestinal and liver involvement in patients with COVID-19: a systematic review and meta-analysis. We analysed findings from 35 studies, including 6686 patients with COVID-19, that met inclusion criteria. 29 studies (n=6064) reported gastrointestinal symptoms in patients with COVID-19 at diagnosis, and the pooled prevalence of digestive system comorbidities was 4% (95% CI 2-5; range 0-15; I2=74%). […] Patients who presented with gastrointestinal system involvement had delayed diagnosis (standardised mean difference 2·85 [95% CI 0·22-5·48]; p=0·030; I2=73%). 2020-05-16
EAPCI Position Statement on Invasive Management of Acute Coronary Syndromes during the COVID-19 pandemic. Modified diagnostic and treatment algorithms are proposed to adapt evidence-based protocols for this unprecedented challenge. 2020-05-20
Diagnosing herpes simplex-1 encephalitis at the time of COVID-19 pandemic. The diagnosis was somehow delayed because relatives were initially cautious in bringing the patient to the hospital and, here, the work-up focus was on coronavirusrelated aspects as the patient was initially reputed to be infected with COVID-19. 2020-05-16
Olfactory dysfunction in the COVID-19 outbreak. To date, the literature is widely heterogeneous regarding the loss of smell; therefore, we advise home isolation measures and/or social distancing, and to carry out diagnostic tests for SARS-CoV-2 when possible in those patients with sudden and severe loss of smell who cannot be promptly evaluated. 2020-05-14
COVID-19: progression of disease and intravascular coagulation - present status and future perspectives. The timely and accurate diagnosis of infection with severe acute respiratory syndrome (SARS) coronavirus 2 (SARS-CoV-2), the cause of coronavirus disease 2019 (COVID-19), remains the cornerstone of efforts to provide appropriated treatment for patients, to limit further spread of the virus and ultimately to eliminate the virus from the human society. […] We focus this article on (a) developments for improvement of diagnosis of specific SARS-CoV-2 virus, (b) laboratory changes in the immunologic and coagulation system, (c) therapeutic options for anticoagulant treatment of seriously affected patients and (d) on the perspectives through improvement of diagnostic and therapeutic medical procedures. 2020-05-14
COVID-19: focus on the lungs but do not forget the gastrointestinal tract. This can lead to delayed diagnosis and inappropriate management of infected patients. 2020-05-14
[Diagnostic algorithm for COVID-19 at the ER]. Evaluation of a diagnostic algorithm for estimating the risk of COVID-19 in patients who are referred to an emergency department for being suspected of having the disease. 2020-05-20
Deep learning for classification and localization of COVID-19 markers in point-of-care lung ultrasound. Deep learning (DL) has proved successful in medical imaging and, in the wake of the recent COVID-19 pandemic, some works have started to investigate DLbased solutions for the assisted diagnosis of lung diseases. […] While existing works focus on CT scans, this paper studies the application of DL techniques for the analysis of lung ultrasonography (LUS) images. […] Experiments on the proposed dataset demonstrate satisfactory results on all the considered tasks, paving the way to future research on DL for the assisted diagnosis of COVID-19 from LUS data. 2020-05-14
Preliminary Estimate of Excess Mortality During the COVID-19 Outbreak - New York City, March 11-May 2, 2020. The counting of confirmed and probable COVID-19-associated deaths might not include deaths among persons with SARS-CoV-2 infection who did not access diagnostic testing, tested falsely negative, or became infected after testing negative, died outside of a health care setting, or for whom COVID-19 was not suspected by a health care provider as a cause of death. 2020-05-15
The clinical implication of dynamic neutrophil to lymphocyte ratio and D-dimer in COVID-19: A retrospective study in Suzhou China. A ROC was calculated to compare the diagnostic performance of candidate indexes, and dynamic levels of hematological indexes were compared between the two groups. 75 patients were enrolled, with a mean age of 46.6 ± 14 years, and 45 patients were male. 2020-05-29
Co-infection with respiratory pathogens among COVID-2019 cases. These results will provide a helpful reference for diagnosis and clinical treatment of COVID-19 patients. 2020-05-29
Deep learning-based multi-view fusion model for screening 2019 novel coronavirus pneumonia: A multicentre study. Based on deep learning method, the proposed diagnosis model trained on multi-view images of chest CT images showed great potential to improve the efficacy of diagnosis and mitigate the heavy workload of radiologists for the initial screening of COVID-19 pneumonia. 2020-05-27
Virtual Screening of Natural Products against Type II Transmembrane Serine Protease (TMPRSS2), the Priming Agent of Coronavirus 2 (SARS-CoV-2). Two techniques were used in the Molecular Operating Environment (MOE) for this purpose, i.e., a ligand-based pharmacophore approach and a molecular docking-based screening. 2020-05-18
Clinical Course, Imaging Features, and Outcomes of COVID-19 in Kidney Transplant Recipients. Future studies with long-term follow up and more cases are needed to elucidate COVID-19 diagnosis, outcome, and management strategies for these patients. 2020-05-18
Coexistence of COVID-19 and acute ischemic stroke report of four cases. There were four stroke cases with simultaneously diagnosis of Covid-19 till the April 14, 2020 in the city of Sakarya, Turkey. 2020-05-18
Neurological manifestations and complications of COVID-19: A literature review. Hence a high index of suspicion is required for timely diagnosis and isolation of cases to prevent the spread in neurology wards. 2020-05-16
How we treat patients with brain tumour during the COVID-19 pandemic. The COVID-19 pandemic has created major insecurities regarding whether we can and should maintain the current standards of diagnosis and treatment and access to care for patients with cancer. 2020-05-16
Asymptomatic COVID-19: What the Neuroradiologist Needs to Know about Pulmonary Manifestations. Asymptomatic infections within a population will inevitably lead to diagnosis via unrelated medical imaging. 2020-05-15
Point-of-care ultrasound and COVID-19. Lung ultrasound has the potential to aid the diagnosis and management of patients with COVID-19 infection. 2020-05-28
Treating acute anxiety in patients with COVID-19. A targeted combination of psychopharmacology (targeting acute anxiety and panic symptoms) and psychotherapy (relaxation techniques, breathing exercises, and encouragement) is recommended. 2020-05-28
Skin manifestations of COVID-19. Some of these cutaneous manifestations arise before the signs and symptoms more commonly associated with COVID-19, suggesting that they could be presenting signs of COVID-19. utaneous manifestations are well known to occur in the setting of viral illnesses, and occasionally these manifestations have diagnostic or prognostic value. 2020-05-16
Clinical characteristics and drug therapies in patients with the common-type coronavirus disease 2019 in Hunan, China. Patients with confirmed COVID-19 diagnosis hospitalized at the study centers from January 17 to February 10, 2020, were included. 2020-05-25
Early trends for SARS-CoV-2 infection in central and north Texas and impact on other circulating respiratory viruses. Rapid diagnosis and isolation are key to containing the quick spread of a pandemic agent like SARS-CoV-2, which has spread globally since its initial outbreak in Wuhan province in China. […] Epidemiological interventions depend on timely availability of accurate diagnostic tests and throughput capacity of such systems during large outbreaks like SARS-CoV-2. 2020-05-15
A case series of chest imaging manifestation of COVID-19. Chest radiography (CXR) and computed tomography (CT) play key roles in managment and diagnosis of COVID-19. 2020-05-15
Radiological Findings in Patients with COVID-19. The current diagnostic options include real-time polymerase chain reaction (RT-PCR) and a few serology tests, including but not limited to the recently approved five minutes serology tests. […] Anecdotal experiences have shown that imaging characteristics are crucial to diagnosis as radiological evidence of disease appears prior to clinical manifestations and tends to evolve over time, which can be useful in predicting the stage of the disease. 2020-05-18
Current and Future Point-of-Care Tests for Emerging and New Respiratory Viruses and Future Perspectives. The availability of pathogen-specific treatment options for respiratory tract infections (RTIs) increased the need for rapid diagnostic tests. […] Although clinical presentation may be similar among different viruses, associated symptoms may range from a mild cold to a severe respiratory illness, and thus require a fast and reliable diagnosis. […] The second key aspect of this work is a description of new and innovative diagnostic techniques, ranging from biosensors to novel portable and current lab-based nucleic acid amplification methods with the potential future use in point-of-care settings. 2020-05-19
Ultraviolet-C and other methods of decontamination of filtering facepiece N-95 respirators during the COVID-19 pandemic. These techniques have been tested previously and have demonstrated efficacy in reducing or inactivating viral and bacterial pathogens, although testing against SARS-CoV-2 specifically has not been done. 2020-05-15
COVID-19 Comes 40 Years After AIDS - Any Lesson? In 1981, the first cases of AIDS were reported and wide diagnostic testing helped to characterize high-risk groups and the global burden of the epidemic. […] Diagnostic testing of active and past SARS-CoV-2 infections needs to expand rapidly, ideally using rapid tests. 2020-05-26
Extracting Possibly Representative COVID-19 Biomarkers from X-ray Images with Deep Learning Approach and Image Data Related to Pulmonary Diseases. X-ray imaging, although limited to specific visualizations, may be helpful for the diagnosis. […] Training the CNNs from scratch outperforms the other transfer learning techniques, both in distinguishing the X-rays between the seven classes and between Covid-19 and non-Covid-19. 2020-05-18
Characterization of the COVID-19 pandemic and the impact of uncertainties, mitigation strategies, and underreporting of cases in South Korea, Italy, and Brazil. In this work, we use mathematical models with time-dependent coefficients, techniques of inverse and forward uncertainty quantification, and sensitivity analysis to characterize essential aspects of the COVID-19 in the three countries mentioned above. 2020-05-18
Diagnostic Tools for Coronavirus Disease (COVID-19): Comparing CT and RT-PCR Viral Nucleic Acid Testing. OBJECTIVE. Multiple studies suggest CT should be a primary diagnostic tool for coronavirus disease (COVID-19) because they reported sensitivities with CT far superior to that of reverse transcriptase polymerase chain reaction (RT-PCR) testing. […] Chest CT should be considered a supplemental diagnostic tool, particularly for patients who show symptoms. 2020-05-15
Impact of the coronavirus (COVID-19) pandemic on surgical practice - Part 2 (surgical prioritisation). The Pandemic has had ramifications for ways of working, surgical techniques, open vs minimally invasive, theatre workflow, patient and staff safety, training and education. 2020-05-18
Should Autism Spectrum Conditions Be Characterised in a More Positive Way in Our Modern World? Given that diagnostic systems are intended to help us better understand conditions in order to seek improved outcomes, we propose a more constructive approach to descriptions that uses more positive language, and balances descriptions of deficits with research finding of strengths and differences. 2020-05-19
“Pairing assistance”: the effective way to solve the breakdown of health services system caused by COVID-19 pandemic. Plotting mortality and diagnosis rates against medical staff resources in 16 cities in Hubei Province, where the epidemic was initially concerned and the most severe, shows a significant negative correlation, indicating the critical role of medical staff resources in controlling epidemics. 2020-05-20
Clinical course of coronavirus disease 2019 in 11 patients after thoracic surgery and challenges in diagnosis. To illustrate the clinical course and difficulties in early diagnosis of coronavirus disease 2019 (COVID-19) in patients after thoracic surgery. […] Insidious symptom onset and misinterpreted postoperative changes on chest computed tomography (CT) resulted in delay in diagnosis. 2020-05-29
Risks from Deferring Treatment for Genitourinary Cancers: A Collaborative Review to Aid Triage and Management During the COVID-19 Pandemic. Patients with muscle-invasive bladder cancer are at risk of disease progression, with radical cystectomy delays beyond 12 wk from diagnosis or completion of neoadjuvant chemotherapy. 2020-05-19
Saliva as an Alternate Specimen Source for Detection of SARS-CoV-2 in Symptomatic Patients Using Cepheid Xpert Xpress SARS-CoV-2. Among the many facets of the SARS-CoV-2 pandemic is the unprecedented pressure it has placed on different points of the supply chain for hospital systems worldwide such as collection devices for the diagnosis of COVID-19. 2020-05-16
Chest CT for detecting COVID-19: a systematic review and meta-analysis of diagnostic accuracy. The purpose of this article was to perform a systematic review and meta-analysis regarding the diagnostic test accuracy of chest CT for detecting coronavirus disease 2019 (COVID-19). […] We included studies providing information regarding diagnostic test accuracy of chest CT for COVID-19 detection. […] The methodological quality was assessed using the Quality Assessment of Diagnostic Accuracy Studies-2 tool. 2020-05-19
Management of valvular and structural heart diseases during the coronavirus disease 2019 pandemic: an expert opinion of the Working Group on Valvular Heart Diseases, the Working Group on Cardiac Surgery, and the Association of Cardiovascular Interventions of the Polish Cardiac Society. In this expert opinion, conceived by the task force involving the Working Groups on Valvular Heart Diseases and Cardiac Surgery as well as the Association of Cardiovascular Intervention of the Polish Cardiac Society, modification of diagnostic pathways, principles of healthcare personnel protection, and treatment guidelines regarding triage and prioritization are suggested. […] Diagnostic tests must be simplified or deferred to minimize the number of potentially dangerous aerosol‑generating procedures, such as transesophageal echocardiography or exercise imaging. 2020-05-29
Lessons Learned from COVID-19 Pandemic in Italy. In this commentary, we discuss some lessons that we learned as healthcare providers working in a large public hospital during the pandemic, with a special focus on the importance of infection containment and early diagnosis, the role of swab, serological tests, home isolation and individual protection devices, and the available therapies and management indications to better face a possible new outbreak in the near future. 2020-05-16
Clinically Applicable AI System for Accurate Diagnosis, Quantitative Measurements, and Prognosis of COVID-19 Pneumonia Using Computed Tomography. However, rapid diagnosis and identification of high-risk patients for early intervention are challenging. […] The AI system can assist radiologists and physicians in performing a quick diagnosis especially when the health system is overloaded. 2020-05-30
On the interactions of the receptor-binding domain of SARS-CoV-1 and SARS-CoV-2 spike proteins with monoclonal antibodies and the receptor ACE2. A promising target for both diagnosis and therapeutics treatments of the new disease named COVID-19 is the coronavirus (CoV) spike (S) glycoprotein. 2020-05-31
Subjective neurological symptoms frequently occur in patients with SARS-CoV2 infection. We included patients hospitalized at the University Hospital of Rome Tor Vergata, medical center dedicated to the treatment of patients with COVID-19 diagnosis, who underwent an anamnestic interview about sNS consisting of 13 items, each related to a specific symptom, requiring a dichotomized answer. 2020-05-22
Lung Ultrasound for Cardiologists in the Time of COVID-19. Lung ultrasound (LUS) is a point-of-care ultrasound (POCUS) technique used for its portability, widespread availability, and ability to provide real-time diagnostic information procedural guidance. […] In this context, LUS emerges as a particularly useful tool for the diagnosis and management of patients with cardiopulmonary disease. 2020-05-22
Metronomic oral vinorelbine and lung cancer therapy during the COVID 19 pandemic: A single-center experience. However, many health workers may be a potential source of infection if not tested with swabs but this diagnostic procedure was not suitable universally in Italy. 2020-05-29
Comparison of seven commercial RT-PCR diagnostic kits for COVID-19. We conclude that all RT-PCR kits assessed in this study may be used for routine diagnostics of COVID-19 in patients by experienced molecular diagnostic laboratories. 2020-05-29
Use of renin-angiotensin-aldosterone system inhibitors and risk of COVID-19 requiring admission to hospital: a case-population study. In this case-population study, we consecutively selected patients aged 18 years or older with a PCR-confirmed diagnosis of COVID-19 requiring admission to hospital from seven hospitals in Madrid, who had been admitted between March 1 and March 24, 2020. 2020-05-31
Biochemical characterization of SARS-CoV-2 nucleocapsid protein. Fluorescence polarization assay showed it has non-specific nucleic acid binding capability, which raised a concern in using it as a diagnostic marker. 2020-05-20
SARS-CoV-2 infection diagnosed only by cell culture isolation before the local outbreak in an Italian seven-week-old suckling baby. Nasal and pharyngeal swabs and a nasopharyngeal aspirate were used for conventional and molecular diagnostic assays not including SARS-CoV-2 virus. […] Cell culture still remains the only reference diagnostic method also for emerging viruses, allowing to reveal cytopathogenic viruses and demonstrating their infectivity. 2020-05-20
Combating COVID-19 Pandemic in Nepal: Ethical Challenges in an Outbreak. As a public health strategy every state has the responsibility of protecting the health of the community and such measures includes the preventive measures like social distancing or even lockdown of the state as a whole restricting the movement of the people, diagnostic measures like testing the suspects, contact tracing and isolation of the patients. 2020-05-21
[Clinical analysis of kidney injury in patients with COVID-19]. However, attention should be paid to acute kidney injury of the elderly patients in the diagnosis and treatment of COVID-19. 目的: 分析新型冠状病毒肺炎(COVID-19)与肾损伤的关系。 2020-05-17
Back-projection of COVID-19 diagnosis counts to assess infection incidence and control measures: analysis of Australian data. Surveillance data on COVID-19 diagnoses can be analysed by the method of back-projection using information about the probability distribution of the time between infection and diagnosis, which is primarily determined by the incubation period. […] These associations were not directly discernible from the daily diagnosis counts, which continued to increase after the first stage of control measures. 2020-05-29
COVID-19 epidemic: Proposed alternatives in the management of digestive cancers: A French intergroup clinical point of view (SNFGE, FFCD, GERCOR, UNICANCER, SFCD, SFED, SFRO, SFR). We propose here adaptations of diagnostic procedures, therapies and care strategies for patients treated for digestive cancer during the COVID-19 epidemic. 2020-05-29
A deep dive into testing and management of COVID-19 for Australian high performance and professional sport. The purpose of testing for any communicable disease is to support clinicians in the diagnosis and management of individual patients and to describe transmission dynamics. 2020-05-22
Viral loads in throat and anal swabs in children infected with SARS-CoV-2. The diagnostic potential of these two types of specimens were showed significant difference (positive rate: 78.2% on throat swabs vs. 2020-05-18
Case Report: COVID-19 Presenting as Acute Undifferentiated Febrile Illness-A Tropical World Threat. The preadmission diagnosis of COVID-19 in this patient enabled appropriate management and isolation to prevent nosocomial transmission. 2020-05-18
The Challenge of Managing Parkinson’s Disease Patients during the COVID-19 Pandemic. Varying degrees of olfactory disturbances may pre-empt the diagnosis of COVID-19. 2020-05-22
Assessing Differential Impacts of COVID-19 on Black Communities. The PAF of COVID-19 diagnosis due to lack of health insurance was 3.3% for counties with <13% black residents and 4.2% for counties with >13% black residents. 2020-05-22
Surgical treatment of diabetic foot ulcers during the COVID-19 pandemic in China. This article describes a proposed strategy for diagnosis and treatment of diabetic foot ulcers, based on experiences with infection and control strategies during the COVID-19 pandemic in China. 2020-05-18
Challenges and countermeasures of thoracic oncology in the epidemic of COVID-19. Outpatient clinics need to strengthen the differential diagnosis of initial symptoms, pulmonary ground-glass opacity (GGO), consolidation, interstitial and/or interlobular septal thickening, and crazy paving appearance. […] In the routine of oncology, the differential diagnosis of adverse events from COVID-19 is also significant, including radiation pneumonitis, checkpoint inhibitor pneumonitis (CIP), neutropenic fever, and so on. 2020-05-22
Clinical characteristics of hospitalised patients with schizophrenia who were suspected to have coronavirus disease (COVID-19) in Hubei Province, China. Even though the remaining 20 (95.2%) were negative for at least two reverse transcription PCR tests, 11 (52.4%) patients met the diagnostic criteria for clinically confirmed cases. 2020-05-22
Management Strategies of Autoimmune bullous diseases during the Outbreak of 2019 Novel Coronavirus Disease (COVID-19). With the spread of the novel coronavirus, the outpatient lines of hospitals have mostly shut down, which means that routine clinical diagnosis and treatment for autoimmune bullous diseases patients have been disturbed. 2020-05-18
AOU Policlinico di Bari - West China Hospital of Sichuan University. Global experience of medical profession, battle, health, friendship against COVID -19. From the preliminary data of this study, it appears that the Bari Polyclinic has adopted the same therapeutic strategies started in China in the previous months, believing early diagnosis and treatment to be a strength in the battle against COVID-19. 2020-05-26
Current laboratory diagnostics of coronavirus disease 2019 (COVID-19). Laboratory medicine provides an almost irreplaceable contribution to the diagnostic reasoning and managed care of most human pathologies. […] The etiological diagnosis of COVID-19 is, and will remain for the foreseeable future, deeply based on direct identification of viral RNA by means of molecular biology techniques in biological materials, especially upper and lower respiratory tract specimens. 2020-05-26
Assessment and treatment of older individuals with COVID 19 multi-system disease: Clinical and ethical implications. This narrative review starts from diagnostic evaluation, continues with adapted pharmacologic treatment and ends with the recovery phase targeting the nutrition and physical exercise. 2020-05-26
Humanism in the Age of COVID-19: Renewing Focus on Communication and Compassion. Given this, there may be no more important time to focus on staff-patient communication and expression of compassion.However, many of the techniques usually employed by emergency clinicians to provide comfort to patients and their families are made more challenging or impossible by the current circumstances. […] Placing emphasis on using these techniques to maximize humanism in the care of COVID-19 patients during this crisis has the potential to bring improvements to ED patient care well after this pandemic has passed. 2020-05-28
Coronavirus Disease 2019-related dyspnea cases difficult to interpret using chest computed tomography. Chest CT has a higher sensitivity and can play an essential role in the diagnosis and treatment of the disease. 2020-05-22
The impact of biosensing in a pandemic outbreak: COVID-19. We spot the urgent needs and highlight innovative diagnostic approaches for targeting various COVID-19 related biomarkers. 2020-05-29
Insights into COVID-19: Mining Physicians’ Opinions on Social Media. Unsupervised and supervised machine learning techniques and text analysis were used to identify topics and opinions. 2020-05-18
Interleukin-1 receptor antagonist anakinra in association with remdesivir in severe Coronavirus disease 2019: A case report. We describe the diagnosis, clinical course, and management of the case, including the respiratory failure at presentation, the progression to a scenario characterized by profound inflammatory dysregulation similar to that observed during macrophage activation syndrome, and the clinical improvement after treatment with the IL-1 receptor antagonist anakinra. 2020-05-20
Diagnosis and treatment of coronavirus disease 2019 (COVID-19): Laboratory, PCR, and chest CT imaging findings. This review focuses on currently available information on the etiology, clinical symptoms, diagnosis, and mechanism of action of COVID-19. […] Furthermore, we present an overview of diagnostic approaches and treatment of this disease according to available findings. 2020-05-22
Saliva sample as a non-invasive specimen for the diagnosis of coronavirus disease 2019: a cross-sectional study. We aimed to investigate the potential use of saliva samples as a non-invasive tool for the diagnosis of COVID-19. […] Saliva might be an alternative specimen for the diagnosis of COVID-19. […] This method could facilitate the diagnosis of the disease, given the simplicity of specimen collection and good diagnostic performance. 2020-05-30
Preparedness of European diagnostic microbiology labs for detection of SARS-CoV-2, March 2020. The main implementation barriers for introduction of a SARSCoV-2 molecular assay in European diagnostic laboratories were availability of positive controls and a specificity panel. 2020-05-29
[COVID-19 Triage: Who is an inpatient? The Essen triage model]. Possible additional parameters are POCT (point-of-care-testing) values, electrocardiogram, CT pulmonary angiography, SARS-Cov2-PCR as well as detailed diagnostic of laboratory values. 2020-05-18
No Autopsies on COVID-19 Deaths: A Missed Opportunity and the Lockdown of Science. The current outbreak of COVID-19 infection, which started in Wuhan, Hubei province, China, in December 2019, is an ongoing challenge and a significant threat to public health requiring surveillance, prompt diagnosis, and research efforts to understand a new, emergent, and unknown pathogen and to develop effective therapies. 2020-05-19
The Rationale for Potential Pharmacotherapy of COVID-19. Moreover, advances in molecular biology techniques and computational analysis have allowed for the better recognition of the virus structure and the quicker screening of chemical libraries to suggest potential therapies. 2020-05-19
Association Between COVID-19 and Kawasaki Disease: Vigilance Required From Otolaryngologists. In the pediatric population, new instances of Kawasaki disease have recently been singled out as presenting in conjunction with or soon after diagnosis of COVID-19. 2020-05-19
Effects of COVID-19 Pandemic on Otolaryngology Surgery in Italy: The Experience of Our University Hospital. Since March 10, the first day of the lockdown in Italy, diagnostic and therapeutic procedures were limited to emergency and oncology cases, while outpatient procedures and clinical examinations were temporarily suspended to limit virus diffusion and to reallocate personnel into wards dedicated to COVID-19. […] In our otolaryngology unit, between March 10 and April 28, 2020, we performed 96 surgical procedures; they mainly consisted in diagnosis and treatment of malignant tumors of the head and neck (77%), management of acute upper airway obstruction in adults and children (14.7%), drainage of abscesses of the head and neck (6.2%), and treatment of nasal bone fractures (2.1%). 2020-05-19
Application of a Modified Endoscopy Face Mask for Flexible Laryngoscopy During the COVID-19 Pandemic. Diagnostic flexible laryngoscopy (DFL) is a critical tool in the armamentarium of an otolaryngologist. 2020-05-19
Clinical course of COVID-19 infection in elderly patient with melanoma on nivolumab. In contrast to her older age, comorbidities, and cancer diagnosis, she was in a good condition, and there was also no pneumonia finding. 2020-05-19
Chest CT imaging characteristics of COVID-19 pneumonia in preschool children: a retrospective study. Accurate diagnosis requires a comprehensive evaluation of epidemiological, clinical, laboratory and CT imaging data. 2020-05-26
False negative chest X-Rays in patients affected by COVID-19 pneumonia and corresponding chest CT findings. Due to the wide availability, rapid execution, low cost, and possibility of being acquired at the patient’s bed, chest X-Ray is a fundamental tool in the diagnosis, follow-up and evaluation of the treatment effectiveness of patients with pneumonia, also in the context of COVID-19 infection. 2020-05-22
ESMO Management and treatment adapted recommendations in the COVID-19 era: Pancreatic Cancer. Since the availability of resources for diagnostic procedures, surgery and postoperative care, systemic therapy and radiotherapy may differ, the authors have separated the prioritisation analyses. […] Therefore, the redefinition of its diagnostic and therapeutic algorithms with a rigorous method is crucial in order to ensure the highest quality of continuum of care in the broader context of the pandemic and the challenged healthcare systems. 2020-05-21
A special symptom of olfactory dysfunction in coronavirus disease 2019: report of three cases. Early diagnosis and intervention are keys to the recovery of olfactory disorders. 2020-05-22
An overview of COVID-19. Meanwhile, recent research has revealed critical aspects of SARS-CoV-2 biology and disease pathogenesis; other studies have focused on epidemiology, clinical features, diagnosis, management, as well as drug and vaccine development. 2020-05-20
Analysis of an improved workflow of endoscope reprocessing for bedside endoscopic diagnosis and treatment on COVID-19 patients. Endoscopic diagnosis and treatment constitute an irreplaceable part in the handling of severe COVID-19 cases. […] Endoscopes, as reusable precision instruments with complicated structures, require more techniques than other medical devices in cleaning, disinfection, sterilization, and other reprocessing procedures. […] Based on the experience we attained from the 12 severe COVID-19 cases in our hospital who underwent endoscopy 23 times in total, the article provides an improved version of endoscopic reprocessing guidelines for bedside endoscopic diagnosis and treatment on COVID-19 patients for reference. 2020-05-20
The role of echocardiography in SARS-CoV-2 pandemic: a compromise among appropriateness, safety and clinical impact. SARS-CoV-2 infection, responsible for COVID-19, can determine cardiac events, which require a quick diagnosis and management, and should not be overlooked due to the presence of COVID-19 infection. […] In patients with COVID-19, the full cardiovascular disease diagnostic algorithm can be hindered by logistic restrain mainly derived from the difficulty of transporting patients in critical conditions to Radiology or Hemodynamics wards. […] The echocardiography in SARS-CoV-2 pandemic can help for differential diagnosis of cardiac events, which can be related or unrelated by the infection and can likely impact on short-term prognosis. 2020-05-20
[Managing cardiac patients post-COVID-19 pandemic: a proposal by the ANMCO Veneto Region]. Here we discuss the most common diagnostic procedures and therapeutic activities, the type of personal protective equipment according to the different tests, the timetable of the different diagnostic examinations, the tele-health services or alternative strategies, and the structural and management requirements, that should be applied to protect patients and healthcare providers in the post-COVID-19 era. 2020-05-20
COVID-19: Current Knowledge and Best Practices for Orthopaedic Surgeons. This review provides a brief understanding of pathophysiology, clinical features, diagnosis and management of COVID-19 and highlights the current knowledge as well as best practices for orthopaedic surgeons. 2020-05-22
SARS-CoV-2 RNA in wastewater anticipated COVID-19 occurrence in a low prevalence area. By using the real-time RT-PCR (RT-qPCR) Diagnostic Panel validated by US CDC that targets three regions of the virus nucleocapsid (N) gene, we estimated quantification of SARS-CoV-2 RNA titers in untreated wastewater samples of 5.4 ± 0.2 log10 genomic copies/L on average. 2020-05-26
Wait-time for hysterectomy and survival of women with early-stage cervical cancer: A clinical implication during the coronavirus pandemic. Wait-time from the diagnosis of invasive cervical cancer via biopsy to definitive surgery was categorized as: short wait-time (<8 weeks; n = 110) versus long wait-time (≥8 weeks; n = 107). 2020-05-22
Swine enteric alphacoronavirus (swine acute diarrhea syndrome coronavirus): An update three years after its discovery. This review summarizes the emergence of SeACoV and updates the research progress made from 2017 to early 2020, mainly focusing on the etiology, epidemiology, evolutionary perspective, potential for interspecies transmission, pathogenesis and diagnosis. 2020-05-23
Weathering the COVID-19 storm: Lessons from hematologic cytokine syndromes. In this review we compare the clinical features, diagnosis, and pathogenesis of COVID-CSS with other hematological CSS, namely secondary hemophagocytic lymphohistiocytosis (sHLH), idiopathic multicentric Castleman disease (iMCD), and CAR-T cell therapy associated Cytokine Release Syndrome (CRS). […] Established markers of inflammation as well as cytokine levels are compared and contrasted between these four entities in order to establish a foundation for future diagnostic criteria of COVID-CSS. 2020-05-22
Extrapulmonary manifestations of COVID-19: Radiologic and clinical overview. Considering the broad spectrum of clinical manifestations and the increasing worldwide burden of the disease, there is an urgent need to rapidly scale up the diagnostic capacity to detect COVID-19 and its complications. 2020-05-29
Unique skin manifestations of COVID-19: Is drug eruption specific to COVID-19? •Drug eruption preceding COVID-19 symptoms may facilitate early diagnosis. 2020-05-22
Altered Mental Status as a Novel Initial Clinical Presentation for COVID-19 Infection in the Elderly. To date, most of the medical literature, including Center for Disease Control guidelines, has relied on three necessary symptoms in making the diagnosis of COVID-19: fever, cough and shortness of breath. 2020-05-22
Clinical Presentation of COVID19 in Dementia Patients. Clinical records of each patients admitted to the hospital with a diagnosis of COVID19 infection were retrospectively analyzed. […] Diagnosis of dementia, modalities of onset of the COVID-19 infection, symptoms of presentation at the hospital and outcomes were recorded. […] In a logistic regression model age, and the diagnosis of dementia resulted independently associated with a higher mortality, and patients diagnosed with dementia presented an OR of 1.84 (95% CI: 1.09-3.13, p<0.05). […] The diagnosis of dementia, especially in the most advanced stages, represents an important risk factor for mortality in COVID-19 patients. 2020-05-22
A preliminary study on serological assay for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in 238 admitted hospital patients. In this study, we aimed to evaluate the diagnostic value of serological assay for SARS-CoV-2. […] The combination of serological assay can greatly improve the diagnostic efficacy. […] After the 11th day post-disease onset, the diagnosis for viral infection should be majorly dependent on serological assay. 2020-05-23
Current Scenario of COVID-19 in Pediatric Age Group and Physiology of Immune and Thymus response. Therefore, in this review, we outline the epidemiology, clinical symptoms, diagnosis, treatment, prevention, possible immune response and role of thymus in children to combat the COVID-19 outbreak. 2020-05-22
Elective procedures for prostate cancer in the time of Covid-19: a multidisciplinary team experience. We compared diagnostic and therapeutic elective procedures requested and performed for PC management from our multidisciplinary team (MDT) during 1 month activity in the highest national level of COVID-19 infection (March 2020) and under restrictions for all the population, with the management performed in a no-COVID-19 month (March 2019) 1 year ago. 2020-05-19
Evaluation of the COVID19 ID NOW EUA assay. The SARS-CoV-2 pandemic caused a major surge in needed diagnostic capacity. 2020-05-22
Minimal Access Gardening: Laparoscopic techniques during COVID-19 lockdown. To demonstrate techniques of laparoscopic surgery while all elective procedures are suspended. […] Stepwise demonstration of key skills required when gardening with minimal access techniques. 2020-05-19
Care of patients with pulmonary arterial hypertension during the coronavirus (COVID-19) pandemic. However, the COVID-19 outbreak may also represent a unique time when pulmonary hypertension experts have to weigh the risks and benefits of the diagnostic work-up including potential exposure to COVID-19 versus initiating targeted pulmonary arterial hypertension therapy in a select high-risk, high likelihood World Symposium Pulmonary Hypertension Group 1 pulmonary arterial hypertension patients. 2020-05-22
Coronavirus: Older Persons With Cancer in Italy in the COVID-19 Pandemic. The deceased patients were older people (median age 80 years) and often had a cancer diagnosis (about 20%). 2020-05-22
The Viral Infection and Respiratory Illness Universal Study (VIRUS): An International Registry of Coronavirus 2019-Related Critical Illness. Critically ill patients with a diagnosis of coronavirus disease 2019. 2020-05-22
Clinical Distancing and Mitigation of Coronavirus Disease 2019. In this commentary, we provide specific recommendations for the rapid implementation of clinical distancing techniques. 2020-05-22
Implications of the lack of a unified research project framework: an investigation into the registration of clinical trials of COVID-19. There were 69.3% interventional studies, 21.7% observational studies, 5.3% diagnostic tests, and 3.7% other studies. 2020-05-19
Natural experiment concept to accelerate the Re-purposing of existing therapeutics for Covid-19. Proposed here is a new but simple concept that would capitalize on the opportunity presented by the on-going natural experiment involving the collection of data from epidemiological surveillance screening and diagnostic testing for clinical treatment. 2020-05-22
[Inpatient psychosomatics in times of the coronavirus]. All patients undergo a clinical and virologic diagnostic process before admittance and receive psychosomatic psychotherapeutic inpatient care, possibly beginning under quarantine conditions. 2020-05-22
An automated Residual Exemplar Local Binary Pattern and iterative ReliefF based corona detection method using lung X-ray image. Radiology doctors use X-ray or CT images for the diagnosis of Covid-19. 2020-05-23
Autonomic Brain Centers and Pathophysiology of COVID-19. Anosmia and agueusia are now well documented and included in the criteria list for diagnosis, and specialists have stressed that doctors screen COVID-19 patients for these two signs. 2020-05-23
COVID-19 Pandemic: Hopes from Proteomics and Multiomics Research. Omics-scale studies on this viral infection are emerging rapidly and offer a tremendous potential to unravel the puzzles of the SARS-CoV-2 pathobiology, and ways forward for diagnostic and therapeutic innovation. 2020-05-19
Opportunity of periodic monitoring of COVID-19 patients, asymptomatic virus carriers, and postinfectious individuals with IgM/IgG rapid antibody tests among healthcare workers during SARS-CoV-2 pandemic. Of the available molecular diagnostic options, in addition to RT-PCR it would be advisable to introduce the novel rapid antibody tests which can give quick results, reveal the timeline of the infection, are easy to handle, inexpensive and can be used periodically to monitor HCWs’ viral status during the still unkown duration of the SARS-CoV-2 pandemic. 2020-05-21
Artificial intelligence-enabled rapid diagnosis of patients with COVID-19. For diagnosis of coronavirus disease 2019 (COVID-19), a SARS-CoV-2 virus-specific reverse transcriptase polymerase chain reaction (RT-PCR) test is routinely used. […] However, this test can take up to 2 d to complete, serial testing may be required to rule out the possibility of false negative results and there is currently a shortage of RT-PCR test kits, underscoring the urgent need for alternative methods for rapid and accurate diagnosis of patients with COVID-19. 2020-05-19
Longitudinal Monitoring of SARS-CoV-2 IgM and IgG Seropositivity to Detect COVID-19. Polymerase chain reaction (PCR) based tests are optimal and recommended for the diagnosis of an acute SARS-CoV-2 infection. 2020-05-19
Acute promyelocytic leukaemia lying under the mask of COVID-19-a diagnostic and therapeutic conundrum. The diagnosis and management of acute promyelocytic leukaemia (APML) in the context COVID-19 poses a challenge for clinicians. 2020-05-19
[Coronavirus (SARS-CoV-2) - Outbreak in North Rhine-Westphalia (District of Heinsberg) - First diagnosis of a COVID-19 manifestation in a couple]. Further on diagnosis of a SARS-CoV-2-infection of both patients with a severe course of the male. 2020-05-22
Use of Saliva for Diagnosis and Monitoring the SARS-CoV-2: A General Perspective. Moreover, a deeper knowledge of potential changes in the saliva proteome in this disease may allow the identification of new diagnostic and prognostic biomarkers, or even help our understanding of the mechanisms associated with the disease. […] With the development of appropriate sample collection and processing methods and the use of adequate assays, saliva can provide useful clinical information about the disease and could be potentially included in guidelines for sample collection for the diagnosis, disease management, and control of Covid-19. 2020-05-20
Update for Anaesthetists on Clinical Features of COVID-19 Patients and Relevant Management. This is a subjective analysis of literature concerning specific topics raised in our daily practice (e.g., clinical features of COVID-19 patients; ventilation of the critically ill COVID-19 patient; diagnostic of infection with SARS-CoV-2; stability of the virus; Covid-19 in specific patient populations, e.g., paediatrics, immunosuppressed patients, patients with hypertension, diabetes mellitus, kidney or liver disease; co-medication with non-steroidal anti-inflammatory drugs (NSAIDs); antiviral treatment) and we believe that these answers help colleagues in clinical decision-making. 2020-05-20
Serology characteristics of SARS-CoV-2 infection since exposure and post symptom onset. Timely diagnosis of SARS-CoV-2 infection is a prerequisite for treatment and prevention. […] The serology characteristics and complement diagnosis value of the antibody test to RNA test need to be demonstrated. […] Serology testing provides an important complement to RNA testing in the later stages of illness for pathogenic specific diagnosis and helpful information to evaluate the adapted immunity status of patients. 2020-05-20
Critical Care Management of Patients with COVID-19: Early Experience in Thailand. We present our initial experience with COVID-19 in Thailand, focusing on several aspects that may have played a crucial role in curtailment of the pandemic, and elements of care for severely ill COVID-19 patients, including stratification, isolation, and affordable diagnostic approaches and supportive care measures. 2020-05-20
COVID-19 Special Column: Principles Behind the Technology for Detecting SARS-CoV-2, the Cause of COVID-19. Nationwide shortages of tests that detect severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and diagnose coronavirus disease 2019 (COVID-19) have led the US Food and Drug Administration (FDA) to significantly relax regulations regarding COVID-19 diagnostic testing. […] To date the FDA has given emergency use authorization (EUA) to 48 COVID-19 in vitro diagnostic tests and 21 high complexity molecular-based laboratory developed tests, as well as implemented policies that give broad authority to clinical laboratories and commercial manufacturers in the development, distribution, and use of COVID-19 diagnostic tests. […] Currently, there are 2 types of diagnostic tests available for the detection of SARS-CoV-2: (1) molecular and (2) serological tests. […] In this article, the SARS-CoV-2 diagnostic tests currently approved by the FDA under EUA are reviewed, and other diagnostic tests that researchers are developing to detect SARS-CoV-2 infection are discussed. 2020-05-26
Impact of Severe Acute Respiratory Syndrome (SARS) on Blood Services and Blood in Hong Kong in 2003. Lessons learnt during the epidemic may help preparation for future epidemics and provide a basis for understanding the pathogenesis, laboratory diagnosis and role of coronaviruses in transfusion medicine. 2020-05-20
SARS2-CoV-2 and Stroke in a New York Healthcare System. We compared the clinical characteristics of stroke patients with a concurrent diagnosis of COVID-19 to stroke patients without COVID-19 (contemporary controls). […] During the study period in 2020, out of 3556 hospitalized patients with diagnosis of COVID-19 infection, 32 patients (0.9%) had imaging proven ischemic stroke. 2020-05-30
A Case of Coronavirus Infection Incidentally Found on FDG PET/CT Scan. A retrospective review of her clinical and laboratory data was strongly suggestive for diagnosis of COVID-19 infection. 2020-05-20
A chronicle of SARS-CoV-2: Part-I - Epidemiology, diagnosis, prognosis, transmission and treatment. The review explicitly covers the aspects like genome and pedigree of SARS-CoV-2; epidemiology, prognosis, pathogenesis, symptoms and diagnosis of COVID-19 in order to catalog the right information on transmission route, and influence of environmental factors on virus transmissions, for the robust understanding of right strategical steps for proper COVID-19 management. 2020-05-29
The Clinical Manifestations and Chest Computed Tomography Findings of Coronavirus Disease 2019 (COVID-19) Patients in China: A Proportion Meta-Analysis. We conducted a proportion meta-analysis to integrate the results of previous studies identified in online databases, and subsequently compared the overlapping of 95% confidence intervals (CIs) between locations of diagnosis. […] When comparing the clinical features according to the location of diagnosis, fever and dyspnea were less frequent in patients diagnosed outside of Wuhan (fever: 78.1%; 95% CI, 73.2% to 82.7%; dyspnea: 3.80%; 95% CI, 0.13% to 12.22%) than in patients diagnosed in Wuhan (fever: 91.7%; 95% CI, 88.0% to 94.8%; dyspnea: 21.1%; 95% CI, 13.2% to 30.3%). […] These results may be attributable to the earlier diagnosis of the disease and the younger age of patients outside of Wuhan although further analysis is needed. […] The role of chest CT in COVID-19 diagnosis is inconclusive based on this study. 2020-05-21
Testing for COVID-19: a few points to remember. Diagnostic approaches to COVID-19 include clinical history, PCR tests for the presence of SARS-CoV-2 virus and detection of antibodies. 2020-05-26
[Asymptomatic SARS-CoV-2 infection in children: a clinical analysis of 20 cases]. Changes in chest CT scan can be used as an aid for early diagnosis of asymptomatic infection in children. 2020-05-26
[Clinical features of coronavirus disease 2019 in children aged <18 years in Jiangxi, China: an analysis of 23 cases]. Epidemiological history is of particular importance in the diagnosis of COVID-19 in children aged <18 years. 2020-05-26
[Coronavirus disease 2019 and hypertension in 2 children]. This article reports the diagnosis and treatment of two children with coronavirus disease 2019 (COVID-19) and hypertension. 2020-05-26
Comparison of Cepheid Xpert Xpress and Abbott ID Now to Roche cobas for the Rapid Detection of SARS-CoV-2. The SARS-CoV-2 pandemic has created an urgent and unprecedented need for rapid large-scale diagnostic testing to inform timely patient management. 2020-05-29
COVID-19 and immune checkpoint inhibitors: initial considerations. Herein, we consider diagnostic and therapeutic implications of using ICI during this unprecedented period of COVID-19 infections. […] In particular, we consider the impact of ICI on COVID-19 severity, decisions surrounding continuing or interrupting therapy, diagnostic measures in patients with symptoms or manifestations potentially consistent with either COVID-19 or ICI toxicity, and resumption of therapy in infected patients. 2020-05-29
Covid-19 and cardiovascular disease. Guideline: Diagnosis and management of cardiovascular disease during the covid-19 pandemicPublished by the European Society of Cardiology.This summary is based on the version published on 21 April 2020 (https://www.escardio.org/Education/COVID-19-and-Cardiology/ESC-COVID-19-Guidance). 2020-05-22
Chest computed tomography findings of coronavirus disease 2019 (COVID-19) pneumonia. • CT plays a crucial role in early diagnosis and assessment of COVID-19 pneumonia progression. 2020-05-23
Low testosterone levels predict clinical adverse outcomes in SARS-CoV-2 pneumonia patients. The pandemic of new severe acute respiratory syndrome (SARS) due to coronavirus (CoV) 2 (SARS-CoV-2) has stressed the importance of effective diagnostic and prognostic biomarkers of clinical worsening and mortality. 2020-05-21
Anosmia Is a Key Symptom of COVID-19 Infection and Should Be Used as a Diagnostic Tool. Based on observations described in our letter, we can draw the following conclusions: (1) anosmia must imperatively be added to the list of specific symptoms of COVID-19 infection, (2) anosmia can serve as a free and specific diagnostic tool for developing countries currently affected by the pandemic, (3) the mechanisms of COVID-19 anosmia seem not to directly involve nasal obstruction but rather seem to be related to damage the olfactory neuroepithelium. 2020-05-21
A review on the use of artificial intelligence for medical imaging of the lungs of patients with coronavirus disease 2019. In this study, we reviewed the AI for diagnostic imaging of COVID-19 pneumonia. 2020-05-21
Hepatic complications of COVID-19 and its treatment. Liver injury may be a risk factor for progresses and worsens in patients with COVID-19, and it is necessary to pay attention to the occurrence of liver injury in the diagnosis and treatment of COVID-19. 2020-05-21
Selective Naked-Eye Detection of SARS-CoV-2 Mediated by N Gene Targeted Antisense Oligonucleotide Capped Plasmonic Nanoparticles. The current outbreak of the pandemic coronavirus disease 2019 (COVID-19) caused by the severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) demands its rapid, convenient, and large-scale diagnosis to downregulate its spread within as well as across the communities. […] But the reliability, reproducibility, and selectivity of majority of such diagnostic tests fail when they are tested either to a viral load at its early representation or to a viral gene mutated during its current spread. […] In this regard, a selective “naked-eye” detection of SARS-CoV-2 is highly desirable, which can be tested without accessing any advanced instrumental techniques. […] Thus, the current study reports a selective and visual “naked-eye” detection of COVID-19 causative virus, SARS-CoV-2, without the requirement of any sophisticated instrumental techniques. 2020-05-28
Prevalence and Clinical Presentation of Health Care Workers With Symptoms of Coronavirus Disease 2019 in 2 Dutch Hospitals During an Early Phase of the Pandemic. During the following weeks, at 2 Dutch teaching hospitals, 9 health care workers (HCWs) received a diagnosis of COVID-19, 8 of whom had no history of travel to China or northern Italy, raising the question of whether undetected community circulation was occurring. […] Only 3 (3%) of the HCWs identified through the screening had a history of travel to China or northern Italy, and 3 (3%) reported having been exposed to an inpatient with a known diagnosis of COVID-19 before the onset of symptoms. 2020-05-30
A report from the Brescia Renal COVID Task Force on the clinical characteristics and short-term outcome of hemodialysis patients with SARS-CoV-2 infection. At disease diagnosis, 37 of the 94 (39%) patients (group 1) were managed on an outpatient basis, whereas the remaining 57 (61%) (group 2) required hospitalization. […] The risk of ARDS and death is significant for patients requiring hospital admission at disease diagnosis. 2020-05-30
Usefulness of bronchoalveolar lavage in the management of patients presenting with lung infiltrates and suspect COVID-19-associated pneumonia: A case report. This case highlights importance of clinical suspicion of SARS-CoV-2 infection in diagnosis and infectivity assessment. […] We suggest collection of BAL fluid when consecutive nasopharyngeal swabs are negative, to confirm or exclude the diagnosis of COVID-19-associated pneumonia. 2020-05-23
Viral exanthem with “Spins and needles sensation” on extremities of a COVID-19 patient: A self-reported case from an Indonesian medical frontliner. The differential diagnosis of drug-induced skin rash and hand-foot-mouth disease was ruled out based on the patient’s previous history and course of the disease. 2020-05-31
International COVID-19 palliative care guidance for nursing homes leaves key themes unaddressed. We applied thematic analysis and narrative synthesis techniques. 2020-05-23
The diagnosis of pandemic coronavirus pneumonia: A review of radiology examination and laboratory test. For the sake of controlling the infectious coronavirus pneumonia, early diagnosis and quarantine play an imperative role. […] Currently, the mainstream diagnostic methods are imaging and laboratory diagnosis, which differ in their efficacy of diagnosis. […] To compare the detection rate, we reviewed numerous literature on pneumonia caused by coronaviruses (SARS, MERS, and SARS-CoV-2) and analyzed two different ways of diagnosis. […] The results showed that the detection rate of computed tomography (CT) diagnosis was significantly higher than that of real-time quantitative polymerase chain reaction (qPCR) (P = 0.00697). 2020-05-29
Endocrinology in the time of COVID-19: Management of hyper- and hypo- thyroidism. The management of patients with a new diagnosis of hyperthyroidism is best undertaken with a block and replace regimen due to limited biochemical testing availability. […] Patients with COVID-19 infection may present with conjunctivitis, which could cause diagnostic difficulties in patients with new or existing Graves’ ophthalmopathy. 2020-05-21
Endocrinology in the time of COVID-19: Management of thyroid nodules and cancer. Most patients with thyroid nodules and thyroid cancer (TC) referred for diagnostic work-up and treatment are not considered at higher risk of infection from SARS-CoV-2 compared to the general population. […] Accordingly, diagnostic work-up of thyroid nodules, thyroid surgery for either benign or malignant thyroid nodules and radioiodine treatment for differentiated thyroid cancers may be safely postponed during SARS-CoV-2 pandemic. […] For these selected cases diagnostic work-up (e.g. ultrasound, scintigraphy, fine-needle aspiration), surgery and radioiodine therapy may proceed despite the threat of SARS-CoV-2 infection and COVID-19, after an individual risk-benefit analysis. 2020-05-21
Comparison of the Characteristics and Outcomes of Coronavirus Disease 2019 in Different Types of Family Infections in Taiwan. Compared to the former two, the starters (cases 19, 24, and 27) of domestic family cluster infections showed longer symptom-onset to diagnosis (p = 0.02); longer symptom-onset to quarantine or isolation (p = 0.01); higher first-generation reproduction number (p = 0.03); and more critical presentation (endotracheal tube insertion and intensive care unit (ICU) care) (p < 0.01). 2020-05-22
Antibody Tests in Detecting SARS-CoV-2 Infection: A Meta-Analysis. The emergence of Coronavirus disease 2019 (COVID-19) caused by SARS-CoV-2 made imperative the need for diagnostic tests that can identify the infection. […] We used the bivariate method for meta-analysis of diagnostic tests pooling sensitivities and specificities. 2020-05-22
ddPCR: a more accurate tool for SARS-CoV-2 detection in low viral load specimens. We further explored the feasibility of ddPCR to detect SARS-CoV-2 nucleic acid from 77 clinical throat swabs, and compared with RT-PCR in terms of the diagnostic accuracy based on the results of follow-up survey. […] Overall, ddPCR shows superiority for clinical diagnosis of SARS-CoV-2 to reduce the false negative reports, which could be a powerful complement to the current standard RT-PCR. 2020-05-22
Computed tomography manifestations in super early stage 2019 novel coronavirus pneumonia. To summarize chest computed tomography (CT) manifestations of the early stage of COVID-19 infection and provide a piece of reliable imaging evidence for initial screening and diagnosis. 2020-05-22
COVID-19, Australia: Epidemiology Report 15 (Reporting week to 23:59 AEST 10 May 2020). Although some low-income countries have currently reported few cases, it is possible that this is due to limited diagnostic and public health capacity, and may not be reflective of disease occurrence. 2020-05-27
Psychiatrist Experience of Remote Consultations by Telephone in an Outpatient Psychiatric Department during the Covid - 19 Pandemic. Diagnostic challenges, the effect of phone consultation on the therapeutic alliance, challenges associated with the use of technology and ethical concerns were identified as issues. 2020-05-22
CT Scanning in Suspected Stroke or Head Trauma: Is it Worth to go the Extra Mile and Include the Chest to Screen for COVID-19 Infection? Diagnostic performance values of chest CT were a sensitivity of 85.7%, specificity of 75.0%, negative predictive value of 93.8%, and positive predictive value of 54.6%. 2020-05-29
Extubation and the Risks of Coughing and Laryngospasm in the Era of Coronavirus Disease-19 (COVID-19). However, the fear of provoking laryngospasm may cause avoidance of deep or sedated extubation techniques which could reduce coughing and infection risk. […] We review the differential diagnosis of acute airway obstruction after extubation, discuss techniques for achieving smooth extubation with avoidance of coughing and expectoration of secretions, and recommend, on the basis of this review, a clinical pathway for optimal management of upper airway obstruction including laryngospasm to avoid adverse outcomes. 2020-05-25
Clinical Characteristics of COVID-19 Infection in Newborns and Pediatrics: A Systematic Review. We should pay special attention to early diagnosis and early treatment in children infected with COVID-19. 2020-05-25
Lobar Distribution of COVID-19 Pneumonia Based on Chest Computed Tomography Findings; A Retrospective Study. This was a retrospective study performed on 63 Iranian adult patients with a final diagnosis of COVID-19. 2020-05-25
Thromboembolism and anticoagulant therapy during the COVID-19 pandemic: interim clinical guidance from the anticoagulation forum. Clinicians around the globe are challenged with rapidly identifying reasonable diagnostic, monitoring and anticoagulant strategies to safely and effectively manage these patients. 2020-05-25
Nonserologic test for COVID-19: How to manage? Diagnosis of Severe Acute Respiratory Coranavirus-2 (SARS-CoV-2) infection is currently based on real-time PCR (RT-PCR) performed on either nasopharyngeal (NPS) or oropharyngeal (OPS) swabs; saliva specimen collection can be used, too. […] Diagnostic accuracy of these procedures is suboptimal, and some procedural mistakes may account for it. […] The video shows how to properly collect secretions from the upper airways for nonserologic diagnosis of COVID-19 by nasopharyngeal swab (NPS), oropharyngeal swab (OPS), and deep saliva collection after throat-cleaning maneuver, all performed under videoendoscopic view by a trained ENT examiner. […] These procedural tricks would enhance diagnostic reliability. 2020-05-22
A Reverse-Transcription Recombinase-Aided Amplification Assay for Rapid Detection of the 2019 Novel Coronavirus (SARS-CoV-2). A specific and rapid diagnostic method is important for early identification. 2020-05-22
CT Features of Coronavirus Disease (COVID-19) in 30 Pediatric Patients. Although recent American College of Radiology recommendations assert that CT should not be used as a screening or diagnostic tool for patients with suspected COVID-19, radiologists should be familiar with the imaging appearance of this disease to identify its presence in patients undergoing CT for other reasons. MATERIALS AND METHODS. We retrospectively reviewed the CT findings and clinical symptoms of 30 pediatric patients with laboratory-confirmed COVID-19 who were seen at six centers in China from January 23, 2020, to February 8, 2020. […] Eleven of 30 patients (37%) underwent follow-up chest CT, with 10 of 11 examinations (91%) showing no change, raising questions about the utility of CT in the diagnosis and management of COVID-19 in children. CONCLUSION. The present study describes the chest CT findings encountered in children with COVID-19 and questions the utility of CT in the diagnosis and management of pediatric patients. 2020-05-22
Ventilation Techniques and Risk for Transmission of Coronavirus Disease, Including COVID-19. To review multiple streams of evidence regarding the benefits and harms of ventilation techniques for coronavirus infections, including that causing COVID-19. 2020-05-27
Characterization of an asymptomatic cohort of SARS-COV-2 infected individuals outside of Wuhan, China. Mean time to diagnosis after close contact with a COVID-19 index patient was 16.0 days (range 1 to 29), and 13.4 days and 18.7 days for those with abnormal and normal CT findings, respectively (p < 0.05). 2020-05-22
Collateral damage: the impact on outcomes from cancer surgery of the COVID-19 pandemic. To avoid a downstream public health crisis of avoidable cancer deaths, cancer diagnostic and surgical pathways must be maintained at normal throughput, with rapid attention to any backlog already accrued. 2020-05-25
Cancer surgery during the Covid-19 pandemic in Turkey. After this date, 39 patients with a diagnosis of cancer were operated on in our clinic. 2020-05-31
Hydroxychloroquine effects on psoriasis: a systematic review and a cautionary note for COVID-19 treatment. Participant demographics, and details of HCQ administration and psoriasis diagnosis were extracted from 15 articles representing 18 patients. 2020-05-24
A review of therapeutic agents and Chinese herbal medicines against SARS-COV-2 (COVID-19). At present, the efforts of various countries focus on the rapid diagnosis and isolation of patients, as well as to find a treatment that can combat the most serious impact of the disease. 2020-05-31
Modelling the evolution trajectory of COVID-19 in Wuhan, China: experience and suggestions. In addition, a novel method is proposed to address the abnormal data on 12-13 February as a result of changing diagnostic criteria. 2020-05-28
Disinfection technology of hospital wastes and wastewater: Suggestions for disinfection strategy during coronavirus Disease 2019 (COVID-19) pandemic in China. Hospitals are important sources of pollutants resulted from diagnostic, laboratory and research activities as well as medicine excretion by patients, which include active component of drugs and metabolite, chemicals, residues of pharmaceuticals, radioactive markers, iodinated contrast media, etc. 2020-05-26
Intensive Care Risk Estimation in COVID-19 Pneumonia Based on Clinical and Imaging Parameters: Experiences from the Munich Cohort. The evolving dynamics of coronavirus disease 2019 (COVID-19) and the increasing infection numbers require diagnostic tools to identify patients at high risk for a severe disease course. 2020-05-25
Point-of-Care Diagnostic Tests for Detecting SARS-CoV-2 Antibodies: A Systematic Review and Meta-Analysis of Real-World Data. To date, assays based on the reverse-transcription polymerase chain reaction (RT-PCR) in respiratory samples are the gold standard for COVID-19 diagnosis. […] Consequently, alternative diagnostic methods are urgently required, both for alleviating the pressure on laboratories and healthcare facilities and for expanding testing capacity to enable large-scale screening and ensure a timely therapeutic intervention. […] Therefore, the present systematic review and meta-analysis was undertaken to explore the feasibility of rapid diagnostic tests in the management of the COVID-19 outbreak. […] We can conclude that: (1) rapid diagnostic tests for COVID-19 are necessary, but should be adequately sensitive and specific; (2) few studies have been carried out to date; (3) the studies included are characterized by low numbers and low sample power, and (4) in light of these results, the use of available tests is currently questionable for clinical purposes and cannot substitute other more reliable molecular tests, such as assays based on RT-PCR. 2020-05-25
COVID-19 Pandemic and Telephone Triage before Attending Medical Office: Problem or Opportunity? Telemedicine, smart phones and apps could represent important devices for the community, in order to prevent virus trasmission and to perform quick diagnosis and management at medical offices. 2020-05-29
Specific EEG Encephalopathy Pattern in SARS-CoV-2 Patients. We objectively identified some numerical EEG features in severely ill COVID patients that can allow positive diagnosis of this encephalopathy. 2020-05-25
Electronic Health Information Systems to Improve Disease Diagnosis and Management at Point-of-Care in Low and Middle Income Countries: A Narrative Review. The demand to explore the use of EHIS for diagnosis and management of communicable and non-communicable diseases has increased dramatically due to the volume of patient data and the need to retain patients in care. […] With guidance from the presented evidence, we proposed EHIS key stakeholders’ roles and responsibilities to ensure efficient utility of EHIS for disease diagnosis and management at POC in LMICs. 2020-05-25
A Fully Automatic Deep Learning System for COVID-19 Diagnostic and Prognostic Analysis. Fast diagnosis of COVID-19, and finding high-risk patients with worse prognosis for early prevention and medical resources optimisation is important. […] Here, we proposed a fully automatic deep learning system for COVID-19 diagnostic and prognostic analysis by routinely used computed tomography.We retrospectively collected 5372 patients with computed tomography images from 7 cities or provinces. 2020-05-23
Clinical features of rheumatic patients infected with COVID-19 in Wuhan, China. Five rheumatic cases used hydroxychloroquine before the diagnosis of COVID-19 and none progressed to critically ill stage. […] Differential diagnosis between COVID-19 and a flare of rheumatic disease should be considered. 2020-05-23
Features of 20 133 UK patients in hospital with covid-19 using the ISARIC WHO Clinical Characterisation Protocol: prospective observational cohort study. The median age of patients admitted to hospital with covid-19, or with a diagnosis of covid-19 made in hospital, was 73 years (interquartile range 58-82, range 0-104). 2020-05-28
Management of patients with multiple myeloma in the era of COVID-19 pandemic: a consensus paper from the European Myeloma Network (EMN). Patient education for personal hygiene and social distancing measures, along with treatment individualization, telemedicine and continuous surveillance for early diagnosis of COVID-19 are essential. 2020-05-27
Impact of the COVID-19 Outbreak on the Management of Patients with Cancer. Cancer wards have been subjected to several modifications to protect patients and healthcare professionals from COVID-19 infection, while attempting to maintain cancer diagnosis, therapy, and research. 2020-05-26
Does this patient have COVID-19? A practical guide for the internist. Physicians need to correctly approach this new disease, often representing a challenge in terms of differential diagnosis. […] We consider two different clinical settings, where availability of the different diagnostic strategies differs widely: outpatient and inpatient. 2020-05-27
Amyotrophic Lateral Sclerosis Care and Research in the USA During the COVID-19 Pandemic: Challenges and Opportunities. Traditional evaluations for making an ALS diagnosis, measuring progression, and planning interventions rely on in-person visits that may now be unsafe or impossible. 2020-05-23
Crisis Standard of Care: Management of Infantile Spasms during COVID-19. The Child Neurology Society collaborated with the Pediatric Epilepsy Research Consortium to issue an online statement April 6, 2020 of immediate recommendations to streamline diagnosis, treatment, and follow up of infantile spasms. 2020-05-23
Clinical Testing For Covid-19. Many nucleic acid tests based on reverse transcriptase-polymerase chain reaction (RT-PCR) were developed, each with different techniques, specifications and turnaround time. […] For surveillance, the need for serologic tests emerged. […] We concentrate on the point-of-care tests and discuss the basis for new serologic tests. […] A unique situation arose of a communicable and highly contagious disease necessitating the rapid diagnosis of patients and the identification of non-symptomatic infected persons. 2020-05-25
COVID-19 identification in chest X-ray images on flat and hierarchical classification scenarios. Early diagnosis is crucial for correct treatment in order to possibly reduce the stress in the healthcare system. […] The standard image diagnosis tests for pneumonia are chest X-ray (CXR) and computed tomography (CT) scan. […] We also explored early and late fusion techniques in the schema in order to leverage the strength of multiple texture descriptors and base classifiers at once. 2020-05-31
Anticipating the impact of the COVID-19 pandemic on TB patients and TB control programmes. Not only can this create diagnostic confusion, but it could worsen the stigmatization of TB patients especially in LMICs, given the fear of COVID-19. 2020-05-29
Ongoing Challenges Faced in the Global Control of COVID-19 Pandemic. The most important priorities are supposed to be i) The development of potential vaccine candidates to provide protection and interrupt the transmission of SARS-CoV-2, ii) To ensure enough supplies for hospitals and their homogeneous distribution among the countries with the worst number of severe cases, iii) There is a need for more studies to identify potential treatments that are effective for the control of this viral infection and iv) It is imperative to provide easy access to diagnostic kits for all countries affected by this pandemic. 2020-05-26
Immunoinformatic analysis of the SARS-CoV-2 envelope protein as a strategy to assess cross-protection against COVID-19. In line with the One-Health approach, our evidences provide a molecular structural rationale for a potential role of taxonomically related coronaviruses in conferring protection from SARS-CoV-2 infection and identifying potential candidates for the development of diagnostic tools and prophylactic-oriented strategies. 2020-05-28
Daring discourse: are we ready to recommend neuraxial anesthesia and peripheral nerve blocks during the COVID-19 pandemic? A pro-con. The benefits of regional anesthetic and analgesic techniques on patient outcomes and healthcare systems are evident. […] Regional techniques are now additionally promoted as a mechanism to reduce aerosolizing procedures. […] We hope this will stimulate dialogue and research into the optimal techniques to improve patient outcomes and ensure practitioner safety during the pandemic. 2020-05-24
Validation of a chemiluminescent assay for specific SARS-CoV-2 antibody. Objectives Faced with the COVID-19 pandemic and its impact on the availability and quality of both therapeutic and diagnostic methods, the Belgian authorities have decided to launch a procedure for additional evaluation of the performance of serological tests offered for sale on the national territory. […] Comparison between the LIAISON®SARS-CoV-2 and the ELISA method did not reveal any difference between the two techniques in terms of sensitivities and specificities regarding the determination of the IgG. 2020-05-27
The impact of COVID-19 pandemic on urological emergencies: a single-center experience. The consequences of a potentially delayed diagnosis remain to be determined. 2020-05-27
Clinical Insights into the Gastrointestinal Manifestations of COVID-19. Moreover, the epidemiology, clinical characteristics, diagnostic procedures, treatments and prevention of the gastrointestinal manifestations of COVID-19 remain to be elucidated. 2020-05-27
SARS-CoV-2 Infection Leads to Neurological Dysfunction. Health care providers currently evaluating patients with neurologic symptoms need consider COVID-19 in any differential diagnosis. 2020-05-28
Repurposing approved drugs as inhibitors of SARS-CoV-2 S-protein from molecular modeling and virtual screening. Herein, molecular modeling techniques were used with the main goal to obtain candidates from a drug database as potential targets to be used against SARS-CoV-2. 2020-05-25
Application of CareDose 4D combined with Karl 3D technology in the low dose computed tomography for the follow-up of COVID-19. Previous studies have shown that the chest CT examination plays an important role in the diagnosis and monitoring of COVID-19. […] The image quality was subjectively evaluated by two senior chest group diagnostic physicians using a 5-point double-blind method. […] CareDose 4D low-dose scanning combined with Karl 3D iterative reconstruction technology can not only greatly reduce the radiation dose, but also provide images that meet the diagnostic criteria of COVID-19, which can be used as a routine method for the follow-up of COVID-19 patients. 2020-05-28
Emergency general surgery in Italy during the COVID-19 outbreak: first survey from the real life. Despite the reduction in number, urgent cases were on average more challenging owing to diagnostic delay. 2020-05-28
The Iranian Society of Echocardiography (ISE) Statement on Performing Echocardiography During the COVID-19 Pandemic. Consequently, diagnostic cardiovascular evaluations such as echocardiography are a crucial part of the disease management. 2020-05-28
Uptrend in distress and psychiatric symptomatology in pregnant women during the COVID-19 pandemic. Multiple regression analyses indicated that COVID-19 pregnant women having a previous psychiatric diagnosis or low income would be more prone to elevated distress and psychiatric symptoms. 2020-05-25
Gender differences in patients with COVID-19: a narrative review. The aim of this narrative review is to underline gender differences in epidemiology, etiopathogenesis, risk factors, clinical presentation, diagnosis, prognosis and mortality of patients infected with SARS-CoV-2. 2020-05-26
Neuropsychiatric symptoms and quality of life in Spanish Alzheimer’s disease patients during COVID-19 lockdown. We tested 40 subjects with a diagnosis of MCI (20) or mild AD (20) from the Cognitive Stimulation Program of Cognitive Disorders Unit. 2020-05-25
Hydroxychloroquine or chloroquine with or without a macrolide for treatment of COVID-19: a multinational registry analysis. Patients who received one of the treatments of interest within 48 h of diagnosis were included in one of four treatment groups (chloroquine alone, chloroquine with a macrolide, hydroxychloroquine alone, or hydroxychloroquine with a macrolide), and patients who received none of these treatments formed the control group. […] Patients for whom one of the treatments of interest was initiated more than 48 h after diagnosis or while they were on mechanical ventilation, as well as patients who received remdesivir, were excluded. 2020-05-29
[Diagnosis and Treatment Protocol for COVID-19 from Military Medical Team Supporting Wuhan (Trial Version 2)]. With the update of the “Diagnosis and Treatment Protocol for Novel Coronavirus Pneumonia” from the National Health Commission of China, the military medical expert group on the front-line has formulated the “Diagnosis and Treatment Protocol for COVID-19 from Military Medical Team Supporting Wuhan(Trial Version 2)” . 2020-05-26
[The analysis of clinical characteristics of 34 novel coronavirus pneumonia cases in Ningxia Hui autonomous region]. COVID-19 could not be excluded if two nucleic acid tests were negative and high-resolution CT was helpful for differential diagnosis. […] Early detection, early isolation, early diagnosis and early treatment are important for good prognosis. 2020-05-26
A Statistical Modeling of the Course of COVID-19 (SARS-CoV-2) Outbreak: A Comparative Analysis. This study aims to provide both a model by using cumulative cases and cumulative death toll for SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) outbreak in 4 countries, China, Italy, South Korea, and Turkey, starting from the first diagnosis and to compare associated indicators. 2020-05-29
Safety and Prognosis in Percutaneous vs Surgical Tracheostomy in 27 Patients With COVID-19. We performed a prospective analysis of a series of 27 consecutive patients with COVID-19 comparing both tracheostomy techniques, safety, and prognosis clinical markers. […] The results show that the techniques are equally safe, without cases of infection in surgeons. 2020-05-26
The management of surgical patients during the coronavirus dieases 2019 (COVID-19) pandemic. Relevant publications reporting on the epidemiology of the pandemic, the diagnosis of the severe acute respiratory syndrome coronavirus 2 infection, and the clinical management of cancer and surgical patients, as well as studies concerning health care workers’ safety, were included. […] Real-time polymerase chain reaction was considered the gold standard for the diagnosis of COVID-19, and computed tomography scans were considered useful for cases of diagnostic uncertainty. 2020-05-29
Do underlying cardiovascular diseases have any impact on hospitalised patients with COVID-19? Considering the high prevalence of CVD, a thorough CVD assessment at diagnosis and early intervention are recommended in COVID-19 patients with CVD. 2020-05-26
The potential effects of widespread community transmission of SARS-CoV-2 infection in the World Health Organization African Region: a predictive model. The needed mitigation measures would significantly strain health system capacities, particularly for secondary and tertiary services, while many cases may pass undetected in primary care facilities due to weak diagnostic capacity and non-specific symptoms. 2020-05-27
Staying home during “COVID-19” decreased fractures, but trauma did not quarantine in one hundred and twelve adults and twenty eight children and the “tsunami of recommendations” could not lockdown twelve elective operations. All the 140 patients presented to the Emergency Department of the hospital during this period with a diagnosis of fracture, or trauma (sprains, dislocations, wounds) were included in the cohort. […] The COVID-19 diagnosis was confirmed for four patients. […] The frequency of patients with confirmed COVID-19 diagnosis among this population treated in emergency was ten fold higher (2.6%; 4 among 152) than in the general population (0.30%) of the country. 2020-05-29
Role of biological Data Mining and Machine Learning Techniques in Detecting and Diagnosing the Novel Coronavirus (COVID-19): A Systematic Review. This study reviewed the state-of-the-art techniques for CoV prediction algorithms based on data mining and ML assessment. […] The growing emphasis on data mining and ML techniques in medical fields can provide the right environment for change and improvement. 2020-05-29
The outlook for diagnostic purposes of the 2019-novel coronavirus disease. Hence, paying more attention to the accurate and immediate diagnosis of suspected and infected cases can be a great help in preventing the rapid spread of the virus, improving the disease prognosis, and controlling the pandemic. […] In this review, we provide a comprehensive and up-to-date overview of the different types of Clinical and Para-clinical diagnostic methods and their practical features, which can help understand better the applications and capacities of various diagnostic approaches for COVID-19 infected cases. 2020-05-26
COVID-19 and pregnancy - where are we now? A review. The diagnosis is based on the exposure history, clinical manifestation, laboratory test results, chest computed tomography (CT) findings and a positive reverse transcription-polymerase chain reaction (RT-PCR) result for coronavirus disease 2019 (COVID-19). 2020-05-26
COVID-19 under spotlight: A close look at the origin, transmission, diagnosis, and treatment of the 2019-nCoV disease. Herein, the COVID-19 structure, epidemiology, pathogenesis, etiology, diagnosis, and therapy have been reviewed. 2020-05-26
COVID-19: Safe Guidelines for Breast Imaging During the Pandemic. Balancing the need to avoid delays in the diagnosis of breast cancer while avoiding infection requires careful attention to personal protective equipment and physical distancing and vigilance to maintain these practices. […] The collateral damage of delaying diagnosis of breast cancer due to COVID-19 should be avoided when possible. 2020-05-26
Airborne Aerosol Generation During Endonasal Procedures in the Era of COVID-19: Risks and Recommendations. Aerosol sampling was additionally performed in simulated clinical and diagnostic settings. 2020-05-28
Using Reports of Symptoms and Diagnoses on Social Media to Predict COVID-19 Case Counts in Mainland China: Observational Infoveillance Study. We found that reports of symptoms and diagnosis of COVID-19 significantly predicted daily case counts up to 14 days ahead of official statistics, whereas other COVID-19 posts did not have similar predictive power. 2020-05-29
A 14-year Prospective Study of Human Coronavirus Infections in Hospitalized Children: Comparison With Other Respiratory Viruses. Episodes of recurrent wheezing were the most common diagnosis, and 112 children (54%) had hypoxia. 2020-05-26
Oncologic patient with COVID-19 discovered incidentally by PET/CT examination: (A COVID–19-pandémia orvosszakmai kérdései) After immediate isolation, the patient was transferred to the corresponding medical department, where further investigations verified the diagnosis of COVID-19. 2020-05-28
International Guidelines And Recommendations For Surgery During Covid-19 Pandemic: A Systematic Review. Prioritization among oncologic cases represents a difficult task: clinicians have to balance a possible delay in cancer diagnosis or treatment against the risk for a potential COVID-19 exposure. 2020-05-29
STEMI during the COVID-19 Pandemic - An Evaluation of Incidence. With fewer patients presenting to hospitals with the diagnosis of STEMI, healthcare workers are wondering what is causing this decline. 2020-05-29
COVID-19 and newborn health: systematic review. One researcher conducted the search and extracted data on demographics, maternal outcomes, diagnostic tests, imaging, and neonatal outcomes. 2020-05-29
Potential therapeutic effect of Qingwen Baidu Decoction against Corona Virus Disease 2019: a mini review. On March 5, 2020, the National Health Commission of the People’s Republic of China issued the Guidelines for the Diagnosis and Treatment of Novel Coronavirus (2019-nCoV) Infection (Trial Version 7), which integrated traditional Chinese medicine (TCM) into the treatment of COVID-19. 2020-05-29
The SpineBox: A Freely Available, Open-access, 3D-printed Simulator Design for Lumbar Pedicle Screw Placement. Results Ten SpineBoxes were created using a single desktop 3D printer, with accurate replication of the cortico-cancellous interface using previously validated techniques. 2020-05-29
Our First Month of Delivering the Prostate Cancer Diagnostic Pathway within the Limitations of COVID-19 Using Local Anaesthetic Transperineal Biopsy. On March 19th the British Association of Urological Surgeons (BAUS) provided pragmatic guidance for prostate cancer diagnostic services (Table 1).( 2020-05-26
Optimization of the CDC Protocol of Molecular Diagnosis of COVID-19 for Timely Diagnosis. A reliable rapid diagnostic test for COVID-19 is demanded worldwide. 2020-05-27
High prevalence of asymptomatic COVID-19 in haemodialysis: learning day by day in the first month of the COVID-19 pandemic. CONCLUSIONS: We detected a high prevalence of COVID-19 with a high percentage detected by screening; hence the need for proactive diagnosis to stop the pandemic. 2020-05-29
ESMO management and treatment adapted recommendations in the COVID-19 era: colorectal cancer. Since the availability of resources for diagnostic procedures, surgery and postoperative care, systemic therapy and radiotherapy may differ, authors did separate prioritisation analyses. […] Therefore, the redefinition of its diagnostic and therapeutic algorithms with a rigorous method is crucial in order to ensure the highest quality of continuum of care in the broader context of the pandemic and the challenged healthcare systems. 2020-05-29
Clinical characteristics and outcomes of patients with coronavirus disease 2019 (COVID-19) and rheumatic disease: a comparative cohort study from a US ‘hot spot’. We conducted a comparative cohort study of patients with rheumatic disease and COVID-19 (confirmed by severe acute respiratory syndrome coronavirus 2 PCR), compared in a 1:2 ratio with matched comparators on age, sex and date of COVID-19 diagnosis, between 1 March and 8 April 2020, at Partners HealthCare System in the greater Boston, Massachusetts area. 2020-05-27
Inside the lungs of COVID-19 disease. Diagnosis was made at necropsy and lung histology showed diffuse alveolar damage, edema, and interstitial pneumonia with a geographically heterogeneous pattern, mostly affecting the central part of the lungs. 2020-05-29
A retrospective study of the initial 25 COVID-19 patients in Luoyang, China. To summarize the chest CT imaging and clinical features of the initial COVID-19 patients and provide a clinical diagnostic method that is more effective and can be performed earlier. […] The median time from initial symptoms to diagnosis was 7 days. 2020-05-29
Non-COVID-19 emergencies: where have all the patients gone? • Early in the pandemic, numbers of patients undergoing non-COVID-19 emergent CTs dropped sharply but diagnostic yield did not increase, suggesting potentially undiagnosed emergencies in patients not seen in healthcare institutions. 2020-05-29
Neurological manifestations of COVID-19: a review of what we know so far. Prompt diagnosis and immediate management of the neurological manifestations of the novel coronavirus will not only improve the prognosis of COVID-19 patients but will also prevent the dissemination of the disease due to misdiagnosed cases. 2020-05-29
The potential long-term impact of the COVID-19 outbreak on patients with non-communicable diseases in Europe: consequences for healthy ageing. Many countries have made changes to routine management of NCD patients, e.g., cancelling non-urgent outpatient visits, which will have important implications for NCD management, diagnosis of new-onset NCDs, medication adherence, and NCD progression. 2020-05-29
Diagnostic performance of immunochromatography assay for rapid detection of IgM and IgG in coronavirus disease 2019. This study was conducted to evaluate the diagnostic performance of an immunochromatography-based assay of human serum for COVID-19. […] In conclusion, the immunochromatography-based COVID-19 IgG/IgM rapid test is a useful and practical diagnostic assay for detection of COVID-19, especially in the presence of IgM or IgG antibodies. 2020-05-27
Glycyrrhetinic acid and its derivatives as potential alternative medicine to relieve symptoms in non-hospitalized COVID-19 patients. Detection of viral genomic materials by RT-PCR is the gold standard for diagnosis. 2020-05-27
Cutaneous manifestations of COVID-19: A review of the published literature. Given the high mortality rate of the infection, timely and accurate identification of relevant cutaneous manifestations may play a key role in the early diagnosis and management. 2020-05-27
Recommendations on management of gynecological malignancies during the COVID-19 pandemic: perspectives from Chinese gynecological oncologists. Medical care decision should be balanced between controlling COVID-19 pandemic spread and timely diagnosis and treatment for gynecologic oncology patients. 2020-05-27
Gynecologic oncology at the time of COVID-19 outbreak. Other minimally invasive techniques, including, vaginal surgery as well as robotic-assisted and isobaric procedures would be preferred over laparoscopy. 2020-05-27
[Pharmacological characteristics of chloroquine and suggestions for its use in treatment of coronavirus disease 2019 (COVID-19)]. Then, chloroquine was included in the Guidelines for the Diagnosis and Treatment of COVID-19 in China (version 6) issued by National Health Commission of the People’s Republic of China. 2020-05-28
Scientific and Standardization Committee Communication: Clinical Guidance on the Diagnosis, Prevention and Treatment of Venous Thromboembolism in Hospitalized Patients with COVID-19. The diagnosis of VTE using standardized objective testing is problematic in these patients, given the risk of infecting non-COVID-19 hospitalized patients and hospital personnel, coupled with the usual challenges of performing diagnostic testing in critically-ill patients. 2020-05-27
Molecular, serological, and biochemical diagnosis and monitoring of COVID-19: IFCC taskforce evaluation of the latest evidence. The global coronavirus disease 2019 (COVID-19) has presented major challenges for clinical laboratories, from initial diagnosis to patient monitoring and treatment. […] Initial response to this pandemic involved the development, production, and distribution of diagnostic molecular assays at an unprecedented rate, leading to minimal validation requirements and concerns regarding their diagnostic accuracy in clinical settings. […] In addition to molecular testing, serological assays to detect antibodies against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are now becoming available from numerous diagnostic manufacturers. […] The International Federation of Clinical Chemistry and Laboratory Medicine (IFCC) Task Force on COVID-19 has been established to synthesize up-to-date information on the epidemiology, pathogenesis, and laboratory diagnosis and monitoring of COVID-19, as well as to develop practical recommendations on the use of molecular, serological, and biochemical tests in disease diagnosis and management. 2020-05-27
The world is waiting, use sequential analysis and get us the evidence-based treatment we need for COVID-19. None of the authors in published literature, as far as we know, used sequential analysis techniques to test potential drugs for COVID-19. 2020-05-27
Intra-Rater and Inter-Rater Reliability of Tongue Coating Diagnosis in Traditional Chinese Medicine Using Smartphones: Quasi-Delphi Study. Tongue diagnosis is an important component of TCM diagnosis. […] However, the procedure of obtaining tongue images has not been standardized and the reliability of tongue diagnosis by smartphone tongue images has yet to be evaluated. […] The first objective of this study was to develop an operating classification scheme for tongue coating diagnosis. […] The second and main objective of this study was to determine the intra-rater and inter-rater reliability of tongue coating diagnosis using the operating classification scheme. […] First, tongue images (n=2023) were analyzed by 2 groups of assessors to develop the operating classification scheme for tongue coating diagnosis. […] Based on clinicians’ (n=17) own interpretations as well as their use of the operating classification scheme, the results of tongue diagnosis on a representative tongue image set (n=24) were compared. 2020-05-27
Children in Critical Care Due to Severe Acute Respiratory Syndrome Coronavirus 2 Infection: Experience in a Spanish Hospital. A chest radiograph led to a pneumonia diagnosis. 2020-05-30
D-dimer and mortality in COVID-19: a self-fulfilling prophecy or a pathophysiological clue? Thromboembolic events are recognised complications of viral infection, but the diagnosis of an acute pulmonary thrombotic complication in the context of coronavirus disease 2019 (COVID-19) can be challenging because of the similarities of presentation, logistical considerations of diagnosis in a patient isolated for infection control reasons and the effects of cognitive errors in diagnostic reasoning. 2020-05-29
B-cell depleting therapies may affect susceptibility to acute respiratory illness among patients with multiple sclerosis during the early COVID-19 epidemic in Iran. Collected data included the current MS DMT and patient-reported disability level, history of recent sick contact, recent fever, respiratory symptoms, diagnosis with COVID-19, and the disposition after the diagnosis. […] We defined a COVID-19-suspect group as patients having fever and cough or fever and shortness of breath, or a presumptive diagnosis based on suggestive chest computed tomography. 2020-05-29
Clinical evaluation of AusDiagnostics SARS-CoV-2 multiplex tandem PCR assay. In the context of the pandemic, the rapid emergency use authorisation of diagnostic assays for SARS-CoV-2 has meant there are few peer-reviewed published studies of clinical performance of commercial assays. 2020-05-29
Clinically significant fear and anxiety of COVID-19: A psychometric examination of the Coronavirus Anxiety Scale. Construct validity was demonstrated with correlations between CAS scores and demographics, coronavirus diagnosis, history of anxiety, coronavirus fear, functional impairment, alcohol/drug coping, religious coping, hopelessness, suicidal ideation, as well as social attitudes (e.g., satisfaction with President Trump). […] The CAS also demonstrated solid discrimination ability for functional impairment (AUC =0.88), while the original cut score of ≥9 (76% sensitivity and 90% specificity) showed the strongest diagnostic effectiveness among scores. 2020-05-29
Delayed Diagnosis of Pediatric Appendicitis during the COVID-19 Pandemic. To present seven pediatric patients with appendicitis, all with late diagnosis resulting from different aspects of the fear from the current global COVID-19 pandemic. […] Main reasons for the delayed diagnosis during the COVID-19 era were parental concern, telemedicine use and insufficient evaluation. […] The fear from COVID-19 pandemic may result in delayed diagnosis and higher complication rates in common pediatric medical conditions. […] We believe care givers as well as healthcare providers should not withhold necessary medical care since delay in diagnosis and treatment in these routinely seen medical emergencies may become as big of a threat as COVID-19 itself. 2020-05-27
Selecting coronavirus disease 2019 patients with negligible risk of progression: early experience from non-hospital isolation facility in Korea. Of 113 patients, 54 (47.8%) were asymptomatic at diagnosis, and 15 (13.3%) had no symptoms until they were released from isolation. […] The risk of progression was negligible in COVID-19 patients who met the admission criteria for LTC at the time of diagnosis. 2020-05-28
COVID-19 in breast cancer patients: a cohort at the Institut Curie hospitals in the Paris area. Common clinical features mostly consisted of fever and/or cough, while ground-glass opacities were the most common radiologic sign at diagnosis. 2020-05-29
The effect of state-level stay-at-home orders on COVID-19 infection rates. Linear regression techniques were used to determine slopes for log case count data, and meta analyses were conducted to combine data across states. 2020-05-30
Absence of nosocomial transmission of coronavirus disease 2019 (COVID-19) due to SARS-CoV-2 in the pre-pandemic phase in Hong Kong. Administrative support with the aim of zero nosocomial transmission by reducing elective clinical services, decanting wards, mobilizing isolation facilities, providing adequate personal protective equipment, coordinating laboratory network for rapid molecular diagnosis under 4-tier active surveillance for hospitalized- and out-patients, and organizing staff forum and training was implemented under the framework of preparedness plan in Hospital Authority. 2020-05-30
Comparison of the Accula SARS-CoV-2 Test with a Laboratory-Developed Assay for Detection of SARS-CoV-2 RNA in Clinical Nasopharyngeal Specimens. Background: Several point-of-care (POC) molecular tests have received emergency use authorization (EUA) from the Food and Drug Administration (FDA) for diagnosis of SARS-CoV-2. 2020-05-28
Baseline characteristics and outcomes of patients with COVID-19 admitted to intensive care units in Vancouver, Canada: a case series. Between Feb. 21 and Apr. 14, 2020, 117 patients were admitted to the ICU with a confirmed diagnosis of COVID-19. 2020-05-28
COVID-19 Waves: Importance of Accumulative Mortality per Million Inhabitants. The reported number of new cases underestimates the real spread of COVID-19 pandemic because of non-tested asymptomatic people and limited global access to reliable diagnostic tests. […] In this context, COVID-19 mortality with confirmed diagnosis becomes an attractive source of information to be included in the analysis of perspectives and proposals. 2020-05-28
Design of a Multiepitope-Based Peptide Vaccine against the E Protein of Human COVID-19: An Immunoinformatics Approach. Several techniques facilitating the combination of the immunoinformatics approach and comparative genomic approach were used in order to determine the potential peptides for designing the T-cell epitope-based peptide vaccine using the envelope protein of 2019-nCoV as a target. 2020-05-30
Coronavirus Disease 2019 (COVID-19) and its implications for cardiovascular care: expert document from the German Cardiac Society and the World Heart Federation. As cardiac injury is a common feature of COVID-19 associated ARDS and is linked with poor outcomes, swift diagnostic management and specialist care of cardiovascular patients in the area of COVID-19 is of particular importance and deserves special attention. 2020-05-30
The COVID-19 Pandemic and its Impact on the Cardio-Oncology Population. Patients with diagnosis of cancer and undergoing treatment further represent a population at risk for worsening cardiopulmonary outcomes. 2020-05-30
SARS-CoV-2 infection, male fertility and sperm cryopreservation: a position statement of the Italian Society of Andrology and Sexual Medicine (SIAMS) (Società Italiana di Andrologia e Medicina della Sessualità). Studies in larger cohorts of currently infected subjects are warranted to confirm (or exclude) the presence of risks for male gametes that are destined either for cryopreservation in liquid nitrogen or for assisted reproduction techniques. 2020-05-30
Impact of the COVID-19 pandemic in nuclear medicine departments: preliminary report of the first international survey. A questionnaire of thirty questions was prepared for all NM professionals addressing three main issues: (1) new scheduling praxes for NM diagnostic and therapeutic procedures, (2) assistance of patients with diagnosed or suspected COVID-19, and (3) prevention of COVID-19 spreading in the departments. […] In most departments, scheduled diagnostic and therapeutic procedures were allowed but quantitatively reduced (112/220, 51%). […] A significant reduction of diagnostic and therapeutic procedures (more than 20%) affected 198/220 (90%) and 158/220 (72%) departments, respectively. 2020-05-30
Any unique image biomarkers associated with COVID-19? To define the uniqueness of chest CT infiltrative features associated with COVID-19 image characteristics as potential diagnostic biomarkers. […] One of the considered models showed non-trivial, but moderate diagnostic ability overall (AUC of 0.70 with 99% CI 0.56-0.85). 2020-05-31
The Allplex 2019-nCoV (Seegene) assay: which performances are for SARS-CoV-2 infection diagnosis? The rates of agreement were 92.7% and 100% with the GeneFinder COVID-19 plus (Elitech) and the diagnosis of the infectious disease specialist respectively. 2020-05-28
The Association between Laryngopharyngeal Reflux and COVID-19 is still not Demonstrated. The LPR diagnosis was based on RSI>13, which is the threshold used by Belafsky et al. to suspect LPR.2 This article is protected by copyright. 2020-05-28
Guidance for Resumption of Routine Electrodiagnostic Testing during the COVID-19 Pandemic. The resumption of non-urgent electrodiagnostic (EDX) testing faces unique challenges due to the long duration of the procedure and direct close contact with patients, including studies with risk of exposure to oropharyngeal secretions. 2020-05-28
Practical Guide for Pediatric Pulmonologists on Imaging Management of Pediatric Patients with COVID-19. This review article synthesizes the reported imaging findings in pediatric COVID-19 across the literature, offers imaging differential diagnostic considerations and useful radiographic features to help differentiate these entities from COVID-19, and provides recommendations for ordering imaging studies to evaluate suspected cases of pediatric COVID-19. 2020-05-28
Shortlisting SARS-CoV-2 Peptides for Targeted Studies from Experimental Data-Dependent Acquisition Tandem Mass Spectrometry Data. Based on these results, a shortlist of 14 peptides from the N, S, and M main structural proteins that could be used for targeted mass-spectrometry method development and diagnostic of the new SARS-CoV-2 is proposed and the best candidates are commented. 2020-05-28
How should colorectal surgeons practice during the COVID-19 epidemic? A retrospective single-center analysis based on real-world data from China. Cancer patients are advised to stay at home in case of potential infection, which may cause delays of routine diagnosis and necessary treatment. 2020-05-28
The Diagnosis of SARS-CoV2 Pneumonia: A Review of Laboratory and Radiological Testing Results. At present, the diagnosis of this infectious form of coronavirus pneumonia is largely dependent upon a combination of laboratory testing and imaging analyses of variable diagnostic efficacy. […] In the present report, we reviewed prior literature pertaining to the diagnosis of different forms of pneumonia caused by coronaviruses (SARS, MERS, and SARS-CoV-2) and assessed two different potential diagnostic approaches. […] We ultimately found that computed tomography (CT) was associated with a higher rate of diagnostic accuracy than was a real-time quantitative polymerase chain reaction (qPCR)-based approach (P = 0.0041), and chest radiography (P = 0.0100). 2020-05-28
Metatranscriptomic Characterization of COVID-19 Identified A Host Transcriptional Classifier Associated With Immune Signaling. The rapidly developing pandemic has posed great challenges to diagnosis of this novel infection. […] The immune-associated host transcriptional signatures of COVID-19 hold promise as a tool for improving COVID-19 diagnosis and indicating disease severity. 2020-05-28
Preliminary CT findings of coronavirus disease 2019 (COVID-19). Ninety-five patients underwent 2-3 SARS-CoV-2 nucleic acid tests and received a definitive diagnosis of COVID-19. 2020-05-30
[Implementation of an operational concept in an ENT clinic in the context of the SARS-CoV-2 pandemic]. Here, patient safety and employee protection are equally important.In cooperation with the Institute for Medical Microbiology and Hospital Hygiene and the occupational medical service, interventions were defined to develop solutions to minimize the COVID-19 transmission risk for examiners and patients despite limited diagnostic and equipment resources. 2020-05-28
Prioritizing and Analyzing the Role of Climate and Urban Parameters in the Confirmed Cases of COVID-19 Based on Artificial Intelligence Applications. In this paper, two artificial intelligence techniques, including an artificial neural network (ANN) based on particle swarm optimization (PSO) algorithm and differential evolution (DE) algorithm, were used for prioritizing climate and urban parameters. 2020-05-29
Challenges in Laboratory Diagnosis of the Novel Coronavirus SARS-CoV-2. The past three unprecedented outbreaks of emerging human coronavirus infections at the beginning of the 21st century have highlighted the importance of readily available, accurate, and rapid diagnostic technologies to contain emerging and re-emerging pandemics. […] Even though excellent techniques are available for the diagnosis of symptomatic patients with COVID-19 in well-equipped laboratories; critical gaps still remain in screening asymptomatic people who are in the incubation phase of the virus, as well as in the accurate determination of live viral shedding during convalescence to inform decisions for ending isolation. […] This review article aims to discuss the currently available laboratory methods and surveillance technologies available for the detection of COVID-19, their performance characteristics and highlight the gaps in current diagnostic capacity, and finally, propose potential solutions. […] We also summarize the specifications of the majority of the available commercial kits (PCR, EIA, and POC) for laboratory diagnosis of COVID-19. 2020-06-02
Graphene-Based Strategies in Liquid Biopsy and in Viral Diseases Diagnosis. Liquid biopsy is considered a revolutionary technique that is opening unexpected perspectives in the early diagnosis and, in therapy monitoring, severe diseases, including cancer, metabolic syndrome, autoimmune, and neurodegenerative disorders. […] Although nanotechnology based on graphene has been poorly applied for the rapid diagnosis of viral diseases, the extraordinary properties of graphene (i.e., high electronic conductivity, large specific area, and surface functionalization) can be also exploited for the diagnosis of emerging viral diseases, such as the coronavirus disease 2019 (COVID-19). […] This review aimed to provide a comprehensive and in-depth summarization of the contribution of graphene-based nanomaterials in liquid biopsy, discussing the remaining challenges and the future trend; moreover, the paper gave the first look at the potentiality of graphene in COVID-19 diagnosis. 2020-05-29
Early Phylogenetic Diversification of SARS-CoV-2: Determination of Variants and the Effect on Epidemiology, Immunology, and Diagnostics. Diagnostic methods might not work if the variations or deletions are in target regions for the detection of the pathogen. 2020-05-29
Discrepancy between Lung Function Measurements at Home and in the Hospital in Children with Asthma and CF. The Coronavirus pandemic stresses the importance of eHealth techniques to monitor patients at home. 2020-05-29
Break in the Stroke Chain of Survival Due to COVID-19. The increasing trend in the prehospital diagnosis of stroke activated by 911 calls stopped abruptly in the region, regressing to 2019 levels. 2020-05-29
Olfactory dysfunction in COVID-19, a review of the evidence and implications for pandemic management. According to the available evidence, it seems reasonable to apply isolation, hygiene and social distancing measures in patients with recent olfactory disorders as the only symptom, although the usefulness of diagnostic tests for this type of patient should be studied. 2020-05-31
Surprise Diagnosis of COVID-19 following Neuroimaging Evaluation for Unrelated Reasons during the Pandemic in Hot Spots. Their initial work-up did not suggest COVID-19 as a diagnosis but showed unsuspected/incidental lung findings, which led to further investigations and a diagnosis of COVID-19. 2020-05-29
Postintubation Dysphagia During COVID-19 Outbreak-Contemporary Review. Recommendations regarding the diagnosis and management of postintubation dysphagia in COVID-19 patients are described in this contemporary review. 2020-05-31
Melanoma Screening Days During the Coronavirus Disease 2019 (COVID-19) Pandemic: Strategies to Adopt. Disease stage represents the most important prognosis factor; therefore, early diagnosis is essential for melanoma patients’ survival rates. […] These measures could cause a delay in melanoma diagnosis and management leading to an increase of morbidity, mortality and healthcare costs. 2020-05-31
Emergency Radiology During the COVID-19 Pandemic: The Canadian Association of Radiologists Recommendations for Practice. These recommendations aim to assist radiologists involved in emergency diagnostic imaging to help mitigate the spread of COVID-19 and continue to add value to patient care in the emergency setting. 2020-05-29
Clinical recommendations on lung cancer management during the COVID-19 pandemic. Here, we provide some suggestions for early identification of COVID-19 and differential diagnosis in patients with lung cancer who have fever and respiratory symptoms. […] KEY POINTS: Significant findings of the study This article provides suggestions for early identification of COVID-19 and differential diagnosis in patients with lung cancer with fever and respiratory symptoms. 2020-06-12
A Case Series of Five People Living with HIV Hospitalized with COVID-19 in Chicago, Illinois. We identified all patients with a diagnosis of HIV who tested positive for SARS-CoV-2 at University of Chicago Medicine between March 1, 2020, and April 7, 2020. […] All were taking antiretroviral therapy (ART) with CD4 count >200 cells/mm3 and suppressed HIV viral loads at the time of COVID-19 diagnosis. 2020-05-29
Chest X-ray features of SARS-CoV-2 in the emergency department: a multicenter experience from northern Italian hospitals. Chest X-ray, compared to CT, can be considered a reliable diagnostic tool, especially in the Emergency setting. 2020-05-31
Possibilities of telemedicine regarding the COVID-19 pandemic in light of the international and Hungarian experiences and recommendations Both international and national data show that telemedicine can play a major role in the triage process, early identification, diagnosis and treatment of infected individuals, and management of patient pathways in a way that ensures the medical team does not come into contact with potentially infected patients. 2020-06-02
Age differences in COVID-19 risk perceptions and mental health:Evidence from a national US survey conducted in March 2020. Demographic variables and pre-crisis depression diagnosis had previously been reported. […] Findings held after additionally controlling for pre-crisis reports of depression diagnosis. 2020-05-29
Letter to the Editor: Are severe COVID-19 patients more susceptible to conjunctivitis? We appreciate the article’s suggestions on protection in ophthalmic diagnosis and treatment, but believe that the data and conclusions in meta-analysis need further study. 2020-05-29
High throughput virtual screening reveals SARS-CoV-2 multi-target binding natural compounds to lead instant therapy for COVID-19 treatment. In the present high throughput virtual screening study, we used in silico techniques like receptor-ligand docking, Molecular dynamic (MD), and ADME properties to screen natural compounds. 2020-05-31
Evaluation of the COVID19 ID NOW EUA assay. The SARS-CoV-2 pandemic caused a major surge in needed diagnostic capacity. 2020-05-29
COVID-19 in elderly kidney transplant recipients. At infection diagnosis, mTOR inhibitors or mycophenolate were withdrawn. 2020-05-29
Laboratory Biomarkers Predicting COVID-19 Severity in the Emergency Room. Laboratory activity becames essential for the timely diagnosis. 2020-05-30
Imported and locally transmitted mild SARS-CoV-2 pneumonia cases in Japan. The laboratory findings revealed normal WBC and CRP despite apparent lung infiltrations, and typical observations on CT imaging were important diagnostic clues. […] In the domestic endemic situation, a comprehensive evaluation of the clinical course, and laboratory and radiological findings was required for diagnosis. 2020-05-30
Performance of Abbott ID NOW COVID-19 rapid nucleic acid amplification test in nasopharyngeal swabs transported in viral media and dry nasal swabs, in a New York City academic institution. The recent emergence of the SARS-CoV-2 pandemic has posed formidable challenges for clinical laboratories seeking reliable laboratory diagnostic confirmation. […] The swift advance of the crisis in the United States has led to Emergency Use Authorization (EUA) facilitating the availability of molecular diagnostic assays without the more rigorous examination to which tests are normally subjected prior to FDA approval. 2020-05-30
Characteristics associated with hospitalisation for COVID-19 in people with rheumatic disease: data from the COVID-19 Global Rheumatology Alliance physician-reported registry. Age, sex, smoking status, rheumatic disease diagnosis, comorbidities and rheumatic disease medications taken immediately prior to infection were analysed. 2020-05-30
Reconfiguring the scope and practice of regional anesthesia in a pandemic: the COVID-19 perspective. The role of percentage saturation of hemoglobin with oxygen (oxygen saturation), blood pressure and early use of point-of-care ultrasound in differential diagnosis and specific management is detailed. 2020-05-30
The COVID-19 infection: lessons from the Italian experience. We strongly recommend that decision-makers:ensure early isolation of symptomatic patients and rapid identification of their contacts;maximize testing rapidly, especially among people with multiple daily contacts with infected populations, high exposure to the public in essential services;rapidly increase diagnostic capacity by mobilizing trained personnel capable of performing rRT-PCR on respiratory samples;equip the population with protective masks. 2020-05-30
Perspectives from Italy during the COVID-19 pandemic: nationwide survey-based focus on minimally invasive HPB surgery. The safety of minimally invasive procedures during COVID pandemic remains hotly debated, especially in a country, like Italy, where minimally invasive techniques have progressively and pervasively entered clinical practice, in both the hepatobiliary and pancreatic community. 2020-05-30
Treatment algorithm for COVID-19: a multidisciplinary point of view. Since the beginning of the COVID-19 outbreak, a growing body of information on diagnostic and therapeutic strategies has emerged, mainly based on preliminary experience on retrospective studies or small case series. 2020-05-30
COVID-19 pandemic and cardiovascular disease: where do we stand? Our knowledge regarding diagnostic approaches, therapeutic management and preventive measures is constantly enriched throughout an abundance of ongoing research in the respective fields. 2020-05-30
2019 novel coronavirus: what is currently known, cardiovascular implications and management. We summarize what makes SARS-CoV2 different from previous highly pathogenic coronaviruses and why it is so contagious, with focus on its clinical presentation and diagnosis, which is mandatory to start the appropriate management and reduce the transmission. 2020-05-30
Age-dependent gender differences of COVID-19 in mainland China: comparative study. We used the national surveillance database of COVID-19 in mainland China to compared gender differences in attack rate (AR), proportion of severe and critical cases (PSCC) and case fatality rate (CFR) in relation to age, affected province, and onset-to-diagnosis interval. […] After adjusting for age, affected province and onset-to-diagnosis interval, the female-to-male difference in AR, PSCC and CFR remained significant in multivariate logistic regression analyses. 2020-05-30
SARS-COV-2 infection presenting as ST-elevationmyocardial infarction. The diagnosis was complicated by two negative tests for SARS-COV-2, and high-clinical suspicion from the patient’s occupational history led to additional testing in order to confirm the diagnosis. 2020-05-30
Pulmonary and cardiac pathology in African American patients with COVID-19: an autopsy series from New Orleans. Autopsies were performed on ten African American decedents aged 44-78 years with cause of death attributed to COVID-19, reflective of the dominant demographic of deaths following COVID-19 diagnosis in New Orleans. 2020-05-30
Evidence for decontamination of single-use filtering facepiece respirators. Utilizing techniques to experimentally contaminate FFRs with a range of microorganisms, most decontamination methods appear to reduce the risk of the mask as a source of infection to the wearer and others to negligible levels. 2020-05-30
A review of South Indian medicinal plant has the ability to combat against deadly viruses along with COVID-19? In future its required to provide medicinal plant based clinical products (Masks, sanitizers, soap etc.) with better techniques by clinicians to contend the scarcity and expose towards the nature based medicine rather than chemical drugs. 2020-05-30
Description of COVID-19 in HIV-infected individuals: a single-centre, prospective cohort. Age and CD4 cell counts in 51 patients diagnosed with COVID-19 were similar to those in 1288 HIV-infected individuals without; however, 32 (63%) with COVID-19 had at least one comorbidity (mostly hypertension and diabetes) compared with 495 (38%) without COVID-19 (p=0·00059). 37 (73%) patients had received tenofovir before COVID-19 diagnosis compared with 487 (38%) of those without COVID-19 (p=0·0036); 11 (22%) in the COVID-19 group had previous protease inhibitor use (mostly darunavir) compared with 175 (14%; p=0·578). 2020-06-03
Clinical impact of COVID-19 on patients with cancer (CCC19): a cohort study. We collected data on baseline clinical conditions, medications, cancer diagnosis and treatment, and COVID-19 disease course. […] The primary endpoint was all-cause mortality within 30 days of diagnosis of COVID-19. 2020-06-23
COVID-19 mortality in patients with cancer on chemotherapy or other anticancer treatments: a prospective cohort study. We excluded patients with a radiological or clinical diagnosis of COVID-19, without a positive RT-PCR test. […] From March 18, to April 26, 2020, we analysed 800 patients with a diagnosis of cancer and symptomatic COVID-19. 412 (52%) patients had a mild COVID-19 disease course. 226 (28%) patients died and risk of death was significantly associated with advancing patient age (odds ratio 9·42 [95% CI 6·56-10·02]; p<0·0001), being male (1·67 [1·19-2·34]; p=0·003), and the presence of other comorbidities such as hypertension (1·95 [1·36-2·80]; p<0·001) and cardiovascular disease (2·32 [1·47-3·64]). 281 (35%) patients had received cytotoxic chemotherapy within 4 weeks before testing positive for COVID-19. 2020-06-23
Neuroleptic malignant syndrome in patients with COVID-19. NMS diagnosis was confirmed, and both, favipiravir and risperidone were discontinued on day 8. 2020-06-05
Intellectual and developmental disability and COVID-19 case-fatality trends: TriNetX analysis. Analysis focused on trends in comorbidities, number of cases, number of deaths, and case-fatality rate among patients with and without IDD who had a positive diagnosis for COVID-19 through May 14, 2020. 2020-06-03
Diagnostic performance of seven rapid IgG/IgM antibody tests and the Euroimmun IgA/IgG ELISA in COVID-19 patients. To evaluate the diagnostic performance of seven rapid IgG/IgM tests and the Euroimmun IgA/IgG ELISA for antibodies against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in COVID-19 patients. […] Positivity of IgM OR IgG for LFA resulted in a decrease in specificity compared to IgG alone without a gain in diagnostic performance, except for VivaDiag. […] The results for IgM varied significantly, and including IgM antibodies in addition to IgG for the interpretation of LFAs did not improve the diagnostic performance. 2020-06-13
Unfolding SARS-CoV-2 viral genome to understand its gene expression regulation. Therefore, we unfolded SARS-CoV-2 viral genome to shed light on its gene expression regulation that could help to design and evaluate diagnostic tests, to track and trace the ongoing outbreak and to identify potential intervention options. 2020-06-27
Mitigating the impact of COVID-19 on oncology: Clinical and operational lessons from a prospective radiation oncology cohort tested for COVID-19. Active tracking, rapid diagnosis, and aggressive source control can mitigate the adverse effects on treatment delays, workforce incapacitation, and ideally outcomes. 2020-06-26
Wastewater surveillance for population-wide Covid-19: The present and future. The mainstay approach for epidemics has long involved the large-scale application of diagnostic testing at the individual case level. […] WBE measures chemical signatures in sewage, such as fragment biomarkers from the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), simply by applying the type of clinical diagnostic testing (designed for individuals) to the collective signature of entire communities. 2020-06-24
Rapid implementation and validation of a cold-chain free SARS-CoV-2 diagnostic testing workflow to support surge capacity. The diagnostic capability was centred on an IVD CE-marked RT-PCR kit and designed to provide surge capacity to the nearby Queen Elizabeth Hospital. 2020-06-18
Oral saliva and COVID-19. COVID-19 can be detected through salivary diagnostic testing which has lots of advantages for medical care professionals and patients. 2020-06-26
Monitoring COVID-19 through Trends in Influenza-like Illness and Laboratory-confirmed Influenza and COVID-19 - New York State, excluding New York City, January 1 - April 12, 2020. In this report, we present temporal data on influenza-like illness, influenza diagnosis and COVID-19 cases for all four regions of New York State through the first six weeks of the outbreak. 2020-05-31
CT in coronavirus disease 2019 (COVID-19): a systematic review of chest CT findings in 4410 adult patients. This review describes the imaging features for diagnosis, stratification, and follow-up of COVID-19 patients. 2020-06-03
Statement from the North American Society for Cardiovascular Imaging on imaging strategies to reduce the scarcity of healthcare resources during the COVID-19 outbreak. They are broadly organized by (1) substituting a noninvasive diagnostic test in place of a semi-invasive or invasive diagnostic tests, and (2) consolidating diagnostic imaging. 2020-06-03
Testing for SARS-CoV-2: the day the world turned its attention to the clinical laboratory. Specifically, we aim to elaborate on the regulatory complexities of diagnostic testing in the U.S. and its implications to the present outbreak, as well as provide a synopsis of laboratory tests that have been developed for COVID-19. […] Subsequently, we will provide an overview of serological tests that can aid not only in diagnosis but additionally help to identify prior infections and potential immunity. 2020-06-19
Patterns of endoscopy during COVID-19 pandemic: a global survey of interventional inflammatory bowel disease practice. Performance of diagnostic or therapeutic endoscopic procedures in inflammatory bowel disease (IBD) patients can be challenging during a viral pandemic; the main concerns being the safety and protection of patients and health care providers (HCP). 2020-06-01
Profiling serum cytokines in COVID-19 patients reveals IL-6 and IL-10 are disease severity predictors. Among them, IL-6 and IL-10 can be used as predictors for fast diagnosis of patients with higher risk of disease deterioration. 2020-06-02
The potential transmission of SARS-CoV-2 from patients with negative RT-PCR swab tests to others: two related clusters of COVID-19 outbreak. The false-negative nasopharyngeal swabs of SARS-CoV-2 caused the delayed diagnosis of COVID-19 which hindered the prevention and control of the pandemic. […] Serologic detection for anti-SARS-CoV-2 IgG and/or IgM is an important test in the assistant diagnosis of COVID-19. 2020-06-01
Coronavirus Disease 2019 (COVID-19): Clinical Perspectives and Ongoing Challenges. Using PubMed, Embase and Medline, articles published between January and April 2020 on Coronavirus disease 2019 (COVID-19), and resources from World Health Organisation were analyzed in order to have an understanding of the clinical characteristics, transmission dynamics, virology, diagnostic possibilities, prevention, management approach, controversies and impact of COVID-19 on the healthcare workforce. 2020-06-03
Olfactory and Gustatory Dysfunction in a COVID-19 Patient with Ankylosing Spondylitis Treated with Etanercept: Case Report. One month after diagnosis, she complained about hyposmia and hypogeusia two days before the seronegative conversion of SARS-CoV-2, which were confirmed by a neurological examination. 2020-06-09
[Otorhinolaryngological aspects of the disease course in children infected with SARS-CoV-2 virus]. In this regard, early diagnosis, including on the basis of symptoms from ENT organs, is crucial. […] However, it is in children in the epidemic aspect that early diagnosis of infection and understanding of its key symptoms is of utmost importance. 2020-06-05
Contact tracing: a lesson from the Nipah virus in the time of COVID-19. Without a vaccine or proven therapeutic options in COVID-19, the World Health Organization (WHO) recommends a combination of measures: rapid diagnosis and immediate isolation of cases; rigorous contact tracing; and precautionary self-isolation of close contacts to curb the spread of COVID-19. 2020-06-01
Delayed specific IgM antibody responses observed among COVID-19 patients with severe progression. Molecular diagnosis of the disease is typically performed via nucleic acid-based detection of the virus from swabs, sputum or bronchoalveolar lavage fluid (BALF). 2020-06-02
Optimal Management of Acute Lymphoblastic Leukemia (ALL) in Adult Patients During the Novel Coronavirus Disease 2019 (COVID-19) Pandemic. In this review, we will address the potential challenges associated with managing ALL patients during the COVID-19 infection pandemic with suggestions of some practical approaches, focusing on screening asymptomatic ALL patients, diagnostic and response evaluation and choice of chemotherapy in different scenarios and setting and use of hematopoietic stem cell transplantation (HSCT). 2020-06-03
Guidance for Remote Reporting of Digital Pathology Slides During Periods of Exceptional Service Pressure: An Emergency Response from the UK Royal College of Pathologists. In this publication produced in response to the pandemic, we provide information regarding risk assessment of home reporting of digital slides, summarize available information on specifications for home reporting computing equipment, and share access to a novel point-of-use quality assurance tool for assessing the suitability of home reporting screens for digital slide diagnosis. 2020-06-04
Analysis and suggestions for the preview and triage screening of children with suspected COVID-19 outside the epidemic area of Hubei Province. With reference to the diagnostic criteria in existing pediatric guidelines, we have further improved the triage screening questionnaire for children with fever in our hospital. […] According to the situation in our city and hospital, an evaluation questionnaire that is suitable for use with children in our hospital has been formulated to achieve the goals of early detection, isolation, diagnosis, and treatment. 2020-06-04
Lung Ultrasound Can Influence the Clinical Treatment of Pregnant Women With COVID-19. Eight pregnant women with a diagnosis of COVID-19 confirmed by nasal/throat real-time reverse transcription polymerase chain reaction testing who underwent point-of-care LUS examinations after routine obstetric ultrasound are described. 2020-06-19
Preloss grief in family members of COVID-19 patients: Recommendations for clinicians and researchers. Researchers have long examined grief-related reactions to the diagnosis of a loved one with a terminal illness, including preloss grief (PLG), which is the experience of grief symptoms prior to the loss of a loved one. 2020-06-04
Systematic Review and Meta-Analysis on the Value of Chest CT in the Diagnosis of Coronavirus Disease (COVID-19): Sol Scientiae, Illustra Nos. OBJECTIVE. The purpose of this article is to systematically review and meta-analyze the diagnostic accuracy of chest CT in detecting coronavirus disease (COVID-19). MATERIALS AND METHODS. MEDLINE was systematically searched for publications on the diagnostic performance of chest CT in detecting COVID-19. […] Methodologic quality was assessed using the Quality Assessment of Diagnostic Accuracy Studies 2 (QUADAS-2) tool. […] The included studies were statistically homogeneous in their estimates of sensitivity (p = 0.578) and statistically heterogeneous in their estimates of specificity (p < 0.001). CONCLUSION. Diagnostic accuracy studies on chest CT in COVID-19 suffer from methodologic quality issues. 2020-06-01
Suitability and Sufficiency of Telehealth Clinician-Observed, Participant-Collected Samples for SARS-CoV-2 Testing: The iCollect Cohort Pilot Study. We aimed to understand whether oropharyngeal swab (OPS), saliva, and dried blood spot (DBS) specimens collected by participants at home and mailed to a laboratory were sufficient for use in diagnostic and serology tests of SARS-CoV-2. 2020-06-26
Cutaneous manifestations in patients with COVID-19: A preliminary review of an emerging issue. Further studies are needed to delineate the diagnostic and prognostic value of such cutaneous manifestations. 2020-06-19
SARS-CoV-2 Antibody Testing - Questions to be asked. However, the interpretation of test results depends on many variables and factors, including sensitivity, specificity, potential cross-reactivity and cross-protectivity; the diagnostic value of antibodies of different isotypes, the use of antibody testing in identification of acutely ill patients or in epidemiological settings. 2020-06-03
Clinical characteristics, outcomes, and risk factors for mortality in patients with cancer and COVID-19 in Hubei, China: a multicentre, retrospective, cohort study. We did a retrospective, multicentre, cohort study of 205 patients with laboratory-confirmed severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and with a pathological diagnosis of a malignant tumour in nine hospitals within Hubei, China, from Jan 13 to March 18, 2020. 2020-06-04
Mortality and pulmonary complications in patients undergoing surgery with perioperative SARS-CoV-2 infection: an international cohort study. In adjusted analyses, 30-day mortality was associated with male sex (odds ratio 1·75 [95% CI 1·28-2·40], p<0·0001), age 70 years or older versus younger than 70 years (2·30 [1·65-3·22], p<0·0001), American Society of Anesthesiologists grades 3-5 versus grades 1-2 (2·35 [1·57-3·53], p<0·0001), malignant versus benign or obstetric diagnosis (1·55 [1·01-2·39], p=0·046), emergency versus elective surgery (1·67 [1·06-2·63], p=0·026), and major versus minor surgery (1·52 [1·01-2·31], p=0·047). 2020-06-04
COVID-19-Associated Encephalitis Mimicking Glial Tumor. For prompt diagnosis and prevention of transmission, clinicians should consider COVID-19 in patients with similar presentation. 2020-06-27
Kidney Infarction in Patients With COVID-19. Our findings implicate that the differential diagnosis of acute kidney injury in COVID-19-infected patients should include kidney infarction, which may have important preventive and therapeutic implications. 2020-06-22
Trend of respiratory pathogens during the COVID-19 epidemic. Therefore, in the present scenario of COVID-19 pandemic, differential diagnosis resulting positive for common respiratory pathogen(s) should not exclude testing of SARS-CoV-2. 2020-06-26
Challenges in the Management of patients with systemic light chain (AL) amyloidosis during the COVID-19 pandemic. Access to health care may be difficult or limited, diagnosis of AL amyloidosis may be delayed with detrimental consequences, treatment administration may need modification. 2020-06-19
A case report with COVID-19 during perioperative period of lobectomy. The patient’s postoperative pathological diagnosis was squamous cell carcinoma of the right lower lung. […] We are the first to report the diagnosis and treatment process of patients with COVID-19 during perioperative period of lobectomy. 2020-06-15
No evidence of severe acute respiratory syndrome-coronavirus 2 in semen of males recovering from coronavirus disease 2019. Severe acute respiratory syndrome-CoV-2 was not detected in semen after a median of 31 days (interquartile range, 29-36 days) from COVID-19 diagnosis. […] Severe acute respiratory syndrome-CoV-2 was not detected in the semen of patients recovering from COVID-19 1 month after COVID-19 diagnosis. 2020-06-10
Adjusting to the new reality: Evaluation of early practice pattern adaptations to the COVID-19 pandemic. Surgical backlog (58.6%), delayed cancer diagnosis (43.2%) and re-establishing normal care with delayed patient (37.8%) were identified as the top 3 challenges after COVID-19 has abated. 2020-06-05
Atypical presentations of coronavirus disease 2019 in a patient with acute obstructive suppurative cholangitis. This particular case is being reported to provide a reference and guidance for the diagnosis and management of COVID-19 in AOSC. 2020-06-05
Swine enteric alphacoronavirus (swine acute diarrhea syndrome coronavirus): An update three years after its discovery. This review summarizes the emergence of SeACoV and updates the research progress made from 2017 to early 2020, mainly focusing on the etiology, epidemiology, evolutionary perspective, potential for interspecies transmission, pathogenesis and diagnosis. 2020-06-27
Clinical performance of the Luminex NxTAG CoV Extended Panel for SARS-CoV-2 detection in nasopharyngeal specimens of COVID-19 patients in Hong Kong. The Luminex NxTAG CoV Extended Panel is a high-throughput FDA emergency use authorized molecular diagnostic assay for SARS-CoV-2 detection. […] This system targets three genes (ORF1ab, N and E gene) of SARS-CoV-2, ORF1ab region of SARS-CoV and ORF5 region of MERS-CoV.In this study, we evaluated the diagnostic performance of this system with nasopharyngeal swab specimens of 214 suspected COVID-19 patients in Hong Kong. […] Overall the E gene target of the NxTAG panel demonstrated the highest sensitivity among the three SARS-CoV-2 targets while the N gene targets demonstrated the least.In conclusion, the NxTAG CoV Extended Panel is simple to use and it has high diagnostic sensitivity and specificity to SARS-CoV-2 in nasopharyngeal specimens. we recommend this diagnostic system for high-throughput COVID-19 screening in the community. 2020-06-02
Cellular pathology in the COVID-19 era: a European perspective on maintaining quality and safety. The COVID-19 pandemic has had a major impact on diagnostic laboratories, particularly those handling cell and tissue specimens. 2020-06-24
SARS-CoV-2: the emergence of a viral pathogen causing havoc on human existence. We have also discussed the diagnosis, treatment and preventive measures that are currently being employed for controlling further spread of the virus. 2020-06-03
Two linear epitopes on the SARS-CoV-2 spike protein that elicit neutralising antibodies in COVID-19 patients. Given the ongoing SARS-CoV-2 pandemic, identification of immunogenic targets against the coronavirus spike glycoprotein will provide crucial advances towards the development of sensitive diagnostic tools and potential vaccine candidate targets. 2020-06-15
What Do We Need to Know to Improve Diagnostic Testing Methods for the 2019 Novel Coronavirus? There is widespread agreement that reliable, fast, and easy-to-produce diagnostic testing methods that have high sensitivity and specificity are essential for guiding appropriate responses to the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) outbreak. […] We discuss the value and limitations of these approaches and suggest directions for future research that can advance the understanding of diagnostic methods. 2020-06-05
Characteristics of registered studies for Coronavirus disease 2019 (COVID-19): A systematic review. Two hundred and sixty-six (67.7%) aimed at therapeutic effect, others were for prevention, diagnosis, prognosis, etc. 2020-06-05
Isolated severe thrombocytopenia in a patient with COVID-19: A case report. A narrow diagnostic approach where only febrile patients with pulmonary symptoms are evaluated for a COVID-19 diagnosis will result in many missed diagnoses; so it is important that physicians are familiar with atypical and rare presentations of COVID-19, such as isolated thrombocytopenia. 2020-06-05
Clinical Validation of a SARS-CoV-2 Real-Time Reverse Transcription PCR Assay Targeting the Nucleocapsid Gene. Detection of SARS-CoV-2 viral RNA is important for the diagnosis and management of COVID-19. 2020-06-26
The neurological manifestations of COVID-19: a review article. During the current context of COVID-19 pandemic, physicians should be aware of wide spectrum of neurological COVID-19 sign and symptoms for early diagnosis and isolation of patients. 2020-06-05
Renal infarct in a COVID-19-positive kidney-pancreas transplant recipient. We describe the first case report of renal allograft infarction in a 46-year-old kidney-pancreas transplant recipient with no prior history of thromboembolism, who presented 26 days after diagnosis of COVID-19. 2020-06-24
Measures to Limit COVID-19 Outbreak Effects Among Military Personnel: Preliminary Data. While we conducted real-time reverse transcriptase polymerase chain reaction SARS-CoV-2 laboratory tests for soldiers who were suspected to have COVID-19 (those presenting with compatible signs and symptoms after having been exposed to a confirmed COVID-19 patient), we were not able to screen healthy populations, nor did we have serum antibody serologic tests available during the study period. 2020-06-26
Time for a Paradigm Shift in Head and Neck Cancer Management During the COVID-19 Pandemic. We aim to review the current evidence regarding the diagnosis and management of head and neck cancer, with an emphasis on the role of the multidisciplinary team (MDT) during a pandemic. 2020-06-02
Infection with SARS-CoV-2 causes abnormal laboratory results of multiple organs in patients. The receiver operating characteristic curve was applied to determine the best diagnostic thresholds for laboratory results, and principal component analysis was used to screen the major risk factors. 2020-06-26
‘’Tociluzumab challenge: A series of cytokine storm therapy experience in hospitalized Covid-19 pneumonia patients’’. Diagnostic tests, laboratory examinations, clinical findings and computed tomography of the thorax imaging results were evaluated. […] Eosinophil values were quite low at the time of diagnosis (10±17.06), but increased significantly post-tocilizumab (155.33±192.69). 2020-06-19
Diagnostic performances and thresholds: The key to harmonization in serological SARS-CoV-2 assays? Diagnostic sensitivity and specificity, positive and negative likelihood ratios were evaluated using manufacturers’ and optimized thresholds. […] Diagnostic sensitivities and specificities were above 93.8% and 85.9%, respectively for all CLIA assays. […] Redefined thresholds, in addition, improved the overall inter-assay agreement, paving the way to a better harmonization of serologic tests. 2020-06-27
A Novel Cohorting and Isolation Strategy for Suspected COVID-19 Cases during a Pandemic. Patients in other groups were cohorted when isolation capacity was limited with additional interventions to reduce transmission. 93 patients were evaluated with 79 (85%) receiving a COVID-19 diagnosis during their admission. […] Of those without a COVID-19 diagnosis: 10 were initially triaged to Category A; 0 to B; 1 to C and 4 to D. 2020-06-05
“Hot Zones” for Otolaryngologists: Assessing the geographic distribution of aerosol-generating procedures amidst the COVID-19 pandemic. The most common AGPs were diagnostic flexible laryngoscopy, diagnostic nasal endoscopy, and flexible laryngoscopy with stroboscopy. 2020-06-26
Diagnostic impact of bedside chest X-ray features of 2019 novel coronavirus in the routine admission at the emergency department: case series from Lombardy region. To evaluate the diagnostic accuracy and the imaging features of routine admission chest X-ray in patients suspected for novel Coronavirus 2019 (SARS-CoV-2) infection. 2020-06-26
Thrombosis risk associated with COVID-19 infection. A scoping review. A number of pressing issues were identified by this review, including defining the true incidence of VTE in COVID patients, developing algorithms to identify those susceptible to develop thrombotic complications and severe disease, determining the role of biomarkers and/or scoring systems to stratify patients’ risk, designing adequate and feasible diagnostic protocols for PE, establishing the optimal thromboprophylaxis strategy, and developing uniform diagnostic and reporting criteria. 2020-06-24
Evaluation of nCoV-QS (MiCo BioMed) for RT-qPCR detection of SARS-CoV-2 from nasopharyngeal samples using CDC FDA EUA qPCR kit as a gold standard: An example of the need of validation studies. Several qPCR kits are available for SARS-CoV-2 diagnosis, mostly lacking of evaluation due to covid19 emergency. […] Validation studies should be implemented for any SARS-CoV-2 RT-qPCR commercial kit to prevent unreliable diagnosis. 2020-06-18
Low performance of rapid antigen detection test as frontline testing for COVID-19 diagnosis. Ensuring accurate diagnosis is essential to limit the spread of SARS-CoV-2 and for the clinical management of COVID-19. […] Although real-time reverse transcription polymerase chain reaction (RT- qPCR) is the current recommended laboratory method to diagnose SARS-CoV-2 acute infection, several factors such as requirement of special equipment and skilled staff limit the use of these time-consuming molecular techniques. […] Recently, several easy to perform rapid antigen detection tests were developed and recommended in some countries as the first line of diagnostic. […] Unfortunately, the overall poor sensitivity of the COVID-19 Ag Respi-Strip does not allow using it alone as the frontline testing for COVID-19 diagnosis. 2020-06-26
Evaluation of the EUROIMMUN Anti-SARS-CoV-2 ELISA Assay for detection of IgA and IgG antibodies. The EUROIMMUN Anti-SARS-CoV-2 ELISA Assay demonstrated good sensitivity for detection of IgA and excellent sensitivity for detection of IgG antibodies from samples collected ≥4 days, after COVID-19 diagnosis by PCR. 2020-06-26
Coping with COVID-19: Exposure to COVID-19 and Negative Impact on Livelihood Predict Elevated Mental Health Problems in Chinese Adults. Mental health problems were assessed with the Post-Traumatic Stress Disorders (PTSD) Checklist for the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5), the Center for Epidemiological Studies Depression inventory, and the Pittsburgh Sleep Quality Index. 2020-06-09
Nanomaterials and Nanotechnology-Associated Innovations against Viral Infections with a Focus on Coronaviruses. These viruses have been scrutinized using rapid diagnostic detection and therapeutic interventional options against the caused infections including vaccine development for prevention and control. […] This perspective review expounds recent nanoscience advancements for the detection and treatment of viral infections with focus on coronaviruses and encompasses nano-based formulations and delivery platforms, nanovaccines, and promising methods for clinical diagnosis, especially regarding SARS-CoV-2. 2020-06-03
[Guide for the prevention and treatment of coronavirus disease 2019]. This article summarized the understanding of the etiology, pathogenesis, epidemiology, clinical characteristics, diagnosis, treatment, rehabilitation, and prevention and control measures of COVID-19 based on the available data and anti-epidemic experience in China. 2020-06-04
Smartphone-Based Self-Testing of COVID-19 Using Breathing Sounds. The acquired breathing sounds can be analyzed using advanced signal processing and analysis in tandem with new deep/machine learning and pattern recognition techniques to separate the breathing phases, estimate the lung volume, oxygenation, and to further classify the breathing data input into healthy or unhealthy cases. 2020-06-03
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2): a review. Herein, we summarize the virology, epidemiology, clinical manifestations, diagnosis, treatment and prevention of SARS-CoV-2, and hope that countries can control the outbreak as soon as possible to minimize the loss. 2020-06-17
SARS-CoV-2 serology: Test, test, test, but interpret with caution! SARS-CoV-2 serological tests are a subject of intense interest and have the potential to significantly enhance the diagnostic capability of healthcare services in the current pandemic. 2020-06-12
Cardiac imaging in congenital heart disease during the coronavirus disease-2019 pandemic: recommendations from the Working Group on Congenital Heart Disease of the Italian Society of Cardiology. The aim of this position paper is to provide clinical recommendation regarding the execution of imaging investigations for the cardiac diagnostic work-up of paediatric patients with suspected or confirmed infection. 2020-06-17
Coding in the World of COVID-19: Non-Face-to-Face Evaluation and Management Care. Medical services can be apportioned as procedural care (eg, surgery, radiology, or laboratory testing and others) or cognitive care, also known as Evaluation and Management (E/M) services, in which the provider formulates an assessment and plan after obtaining information from the patient’s history, examination, and diagnostic tests.Providing a medical opinion and plan using the telephone as the technology that links the provider and the patient is an example of a non-face-to-face E/M service. 2020-06-11
[Psychopharmacotherapy during the COVID-19 pandemic]. Direct contact to patients may have to be reduced in favor of telephone calls or video conferences, so that new techniques in diagnosing and treating patients have to be established to guarantee patient safety. 2020-06-05
Asymptomatic carriage and transmission of SARS-CoV-2: What do we know? Techniques to minimize aerosolization and appropriate personal protective equipment may help reduce the risk to healthcare workers in the operating room. 2020-06-05
[Application of Reyanning Mixture in evaluating combining disease with syndrome of human coronavirus pneumonia with pestilence attacking lung syndrome]. In the previous research, our laboratory established a mouse model combining disease with syndrome of human coronavi-rus pneumonia with pestilence attacking the lung syndrome, based on the national traditional Chinese medicine clinical classification of Novel Coronavirus Infected Pneumonia Diagnosis and Treatment Plan. 2020-06-05
[Therapeutic effect of Compound Qinlan Oral Liquid on treating combining disease with syndrome of human coronavirus pneumonia with pestilence attacking lung syndrome]. This model is suitable for simulating traditional Chinese medicine treatment of common disease syndromes in Novel Coronavirus Pneumonia Diagnosis and Treatment program(trial implementation of the sixth edition). 2020-06-05
[Discovery of intervention effect of Chinese herbal formulas on COVID-19 pulmonary fibrosis treated by VEGFR and FGFR inhibitors]. According to 2 prescriptions in the Protocol for the diagnosis and treatment of coronavirus disease 2019(7th edition)and 9 prescriptions in Traditional Chinese medicine prescriptions for treating blight, 959 and 1 047 potential ingredients were obtained as the inhibitors of VEGFR and FGFR respectively with the screening thres-hold set as eighty percent of the docking score of the initial ligands. 2020-06-05
[Thoughts and suggestions on arrangement, analysis and summary of medical data during COVID-19 epidemic]. The analysis and utilization of clinical scientific research data is an effective means to promote the progress of diagnosis and treatment, and a key step in the development of medical sciences. […] During the epidemic of coronavirus disease 2019(COVID-19), how to transform the limited diagnostic data into clinical research resources has attracted much attention. 2020-06-05
COVID-19 and Renal Failure: Challenges in the Delivery of Renal Replacement Therapy. We discussed measures required to limit the spread of infection, as well as summarized the guidance as per the Centers for Disease Control and Prevention (CDC), American Society of Nephrology (ASN), American Society of Diagnostic and Interventional Nephrology (ASDIN) and the Vascular Access Society of the Americas (VASA). 2020-06-05
A Comprehensive Approach Is Vital for Diagnosing COVID-19: A Case of False Negative. The clinicians should be aware of the sensitivity and specificities of these tests which can have grave implications on the patient and community if the diagnosis is missed just based on the laboratory tests due to the highly contagious nature of the disease. 2020-06-05
Immune Characteristics of Patients with Coronavirus Disease 2019 (COVID-19). Furthermore, there was also a negative correlation between lymphocytes (r = -0.54, p = 0.038) or T cells (r = -0.55, p = 0.034) at diagnosis and the nucleic acid-positive duration, separately. 2020-06-05
Basal Ganglia Involvement and Altered Mental Status: A Unique Neurological Manifestation of Coronavirus Disease 2019. Based on the case presented and other cases, understanding the pathways of virus neuroinvasion is necessary to help recognize possible pathologically related consequences of infection and to evaluate new diagnostic and management approaches that will help improve SARS-CoV-2 infection treatment and control. 2020-06-05
Chinese Society of Interventional Radiology Expert Consensus on the prevention and control of COVID-19 in interventional radiology procedures (first edition). The COVID-19 pandemic seriously threatens the lives of the general public and poses momentous challenges to all medical workers, including those engaged in interventional radiology, who play an important role in the diagnosis and treatment of various diseases. […] To further standardize the prevention and control of nosocomial infections and ensure the safety of doctors and patients, the Chinese Society of Interventional Radiology (CSIR) organized multidisciplinary experts in the field of interventional radiology in China to prepare an “Expert Consensus” elaborating and summarizing the protective strategies and suggestions for medical workers in the field of interventional radiology when they engage in interventional diagnosis and treatment activities against the background of novel coronavirus infection control. […] The key points include the following: (I) non-emergency interventional diagnosis and treatment should be suspended while work is ongoing to prevent and control the spread of COVID-19; (II) protective measures should be taken according to the appropriate level designated for COVID-19 infection prevention and control; (III) patients should take measures to protect themselves when they want to see a doctor, including accessing outpatient services online and other relevant channels of consultation. 2020-06-05
A systematic review of chest imaging findings in COVID-19. However, its role as a screening and diagnostic tool in COVID-19 remains to be clarified. […] This article provides a systematic review and meta-analysis of the current literature on chest CT imaging findings with the aim of highlighting the contribution and judicious use of CT in the diagnosis of COVID-19. […] Chest imaging abnormalities associated with COVID-19 were extracted from the eligible studies and diagnostic value of CT in detecting these abnormal changes was compared between studies consisting of both COVID-19 and non-COVID-19 patients. […] Despite widespread use of CT in the diagnosis of COVID-19 patients based on the current literature, CT findings are not pathognomonic as it lacks specificity in differentiating imaging appearances caused by different types of pneumonia. […] Use of CT as a first-line diagnostic or screening tool in COVID-19 is not recommended. 2020-06-05
Machine Learning to Detect Self-Reporting of Symptoms, Testing Access, and Recovery Associated With COVID-19 on Twitter: Retrospective Big Data Infoveillance Study. These tweets were grouped into five main categories including first- and secondhand reports of symptoms, symptom reporting concurrent with lack of testing, discussion of recovery, confirmation of negative COVID-19 diagnosis after receiving testing, and users recalling symptoms and questioning whether they might have been previously infected with COVID-19. 2020-06-15
Adults at high-risk of severe coronavirus disease-2019 (Covid-19) in Brazil. We estimated the proportion and number of adults (≥ 18 years) at risk of severe Covid-19 by sex, educational level, race/ethnicity, and state based on the presence of one or more of the following risk factors: age ≥ 65 years or medical diagnosis of cardiovascular disease, diabetes, hypertension, chronic respiratory disease, cancer, stroke, chronic kidney disease and moderate to severe asthma, smoking status, and obesity. 2020-06-11
Sexually Transmitted Infections during the COVID-19 outbreak: comparison of patients referring to the service of sexually transmitted diseases during the sanitary emergency with those referring during the common practice. In 1991 and 2009 the Italian sentinel surveillance system was established, consisting in 25 public centers (12 clinical, 13 laboratories) on the national field for diagnosis, treatment and data transmission to the INIH4 . 2020-06-19
Clinical Potential of UTE-MRI for Assessing COVID-19: Patient- and Lesion-Based Comparative Analysis. Chest computed tomography (CT) has shown tremendous clinical potential for screening, diagnosis, and surveillance of COVID-19. 2020-06-19
The different tests for the diagnosis of COVID-19 - A review in Brazil so far. In here we present a comparison among the current diagnostic tools and kits being used to test Brazilian population. 2020-06-03
Prevalence of Asymptomatic SARS-CoV-2 Infection: A Narrative Review. To supplement conventional diagnostic testing, which is constrained by capacity, cost, and its one-off nature, innovative tactics for public health surveillance, such as crowdsourcing digital wearable data and monitoring sewage sludge, might be helpful. 2020-06-19
SARS-CoV-2: A comprehensive review from pathogenicity of the virus to clinical consequences. In this review article, we have collected the latest data about characteristics, pathogenesis, clinical manifestations, and diagnostic methods of SARS-CoV-2. 2020-06-19
‘’Determining Host Factors Contributing to Disease Severity in a Family Cluster of 29 Hospitalized SARS-CoV-2 Patients: Could Genetic Factors Be Relevant in the Clinical Course of COVID-19?’’. The virus was detected for diagnosis. 2020-06-19
Comparison of clinical and epidemiological characteristics of asymptomatic and symptomatic SARS-CoV-2 infection: A multi-center study in Sichuan Province, China. 27.4% of well-documented asymptomatic cases developed delayed symptoms after the pathogenic diagnosis. 60% of asymptomatic cases demonstrated findings of pneumonia on the initial chest CT, including well-recognized features of coronavirus disease-19. 2020-06-08
Fast SARS-CoV-2 detection by RT-qPCR in preheated nasopharyngeal swab samples. The gold-standard COVID-19 diagnosis relies on detecting SARS-CoV-2 using RNA purification and one-step retrotranscription and quantitative PCR (RT-qPCR). […] Our findings provide valuable options to overcome any supply chain issue and help to increase the throughput of diagnostic tests, thereby complementing standard diagnosis. 2020-06-28
Clinical Features and Short-term Outcomes of Elderly Patients With COVID-19. Early diagnosis and supportive care are of great importance for the elderly patients of COVID-19. 2020-06-05
COVID-19 Pandemic and Role of Human Saliva as a Testing Biofluid in Point-of-Care Technology. Saliva is proving to be a promising noninvasive sample specimen for the diagnosis of COVID-19, thus helping to monitor the infection and prevent it from further spreading by prompt isolation. 2020-06-03
[SARS-CoV-2 infection (COVID-19): what can we expect?] Low-threshold diagnostic testing and rapid detection of infection chains remain essential for better control of the pandemic. 2020-06-09
Diagnostic Performance of a Rapid Point of Care Test for SARS-CoV-2 in an Urban ED Setting. This was made possible by increasing availability of diagnostic molecular tests in several formats, from laboratory based traditional, RT-PCR methods to near patient testing rapid point of care PCR tests. 2020-06-19
Utility of lateral flow tests in SARS-CoV-2 infection monitorization. The diagnosis of SARS-CoV-2 infection is crucial for medical and public health reasons, to allow the best treatment of cases and the best control of the pandemic. […] Rapid serology tests are useful for the diagnosis of patients with COVID-19 (mainly IgG detection) and may also be correlated with the severity of the infection (based on IgM detection). 2020-06-04
Repair of Acute Respiratory Distress Syndrome by Stromal Cell Administration in COVID-19 (REALIST-COVID-19): A structured summary of a study protocol for a randomised, controlled trial. Patients with moderate to severe ARDS as defined by the Berlin definition, receiving invasive mechanical ventilation and with a diagnosis of COVID-19 based on clinical diagnosis or PCR test will be eligible. 2020-06-10
A randomized multicenter clinical trial to evaluate the efficacy of melatonin in the prophylaxis of SARS-CoV-2 infection in high-risk contacts (MeCOVID Trial): A structured summary of a study protocol for a randomised controlled trial. Inclusion Criteria: Male or female participants ≥ 18 and ≤ 80 years of age.Healthcare workers from the public and private Spanish hospital network at risk of SARS-CoV 2 infection.Not having a previous COVID19 diagnosis.Understanding the purpose of the trial and not having taken any pre-exposure prophylaxis (PrEP) including HIV PrEP from March 1st 2020 until study enrolment.Having a negative SARS-CoV 2 reverse-transcription PCR (RT-PCR) result or a negative serologic rapid test (IgM/IgG) result before randomization.Premenopausal women must have a negative urinary pregnancy test in the 7 days before starting the trial treatment.Premenopausal women and males with premenopausal couples must commit to using a high efficiency anticonceptive method. […] Number of SARS-CoV-2 (COVID-19) symptomatic infections confirmed by polymerase chain reaction (PCR) test or serologic test or according to each centre diagnosis protocol. 2020-06-10
Efficacy of hydroxychloroquine for post-exposure prophylaxis to prevent severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection among adults exposed to coronavirus disease (COVID-19): a structured summary of a study protocol for a randomised controlled trial. Had a close contact of a person (index) with known PCR-confirmed SARS-CoV-2 infection or index who is currently being assessed for COVID-19 Close contact is defined as: a.Household contact (i.e., residing with the index case in the 14 days prior to index diagnosis or prolonged exposure within a residence/vehicle/enclosed space without maintaining social distance)b.Medical staff, first responders, or other care persons who cared for the index case without personal protection (mask and gloves)4. 2020-06-10
Controlled, double-blind, randomized trial to assess the efficacy and safety of hydroxychloroquine chemoprophylaxis in SARS CoV2 infection in healthcare personnel in the hospital setting: A structured summary of a study protocol for a randomised controlled trial. 1)Intervention: (n = 225): One 200 mg hydroxychloroquine sulfate coated tablet once daily for two months.2)Comparator (control group) (n = 225): One hydroxychloroquine placebo tablet (identical to that of the drug) once daily for two months MAIN OUTCOMES: The primary outcome of this study will be to evaluate: number and percentage of healthcare personnel presenting symptomatic and asymptomatic infection (see “Diagnosis of SARS CoV2 infection” below) by the SARS-Cov2 virus during the study observation period (8 weeks) in both treatment arms;number and percentage of healthcare personnel in each group presenting with Pneumonia with severity criteria (Curb 65 ≥2) and number and percentage of healthcare personnel requiring admission to the Intensive Care Unit (ICU) in both treatment arms. […] DIAGNOSIS OF SARS COV2 INFECTION: Determination of IgA, IgM and IgG type antibodies against SARS-CoV-2 using the Anti-SARS-CoV-2 ELISA kit (EUROIMMUN Medizinische Labordiagnostika AG, Germany) every two weeks. 2020-06-10
A prospective, randomised, double blind placebo-controlled trial to evaluate the efficacy and safety of tocilizumab in patients with severe COVID-19 pneumonia (TOC-COVID): A structured summary of a study protocol for a randomised controlled trial. Simultaneous participation in other interventional trials (except for participation in COVID-19 trials) which could interfere with this trial; simultaneous participation in registry and diagnostic trials is allowed15. 2020-06-10
[Influence of the coronavirus 2 (SARS-Cov-2) pandemic on acute appendicitis]. The SARS-Cov-2 pandemic influenced the time of diagnosis of appendicitis, as well as its course, and mean hospital stay. […] As a result of the significant circumstances, delaying diagnosis and treatment of AA during SARS-Cov-2 pandemic, inappropriate management of this common surgical disorder has been noticed. 2020-06-06
COVID-19 Outbreak in Malaysia. In this review the SARS-CoV-2 morphology, pathogenic mechanism, similarities and differences between SARS-CoV and Middle East Respiratory Syndrome and severe acute respiratory syndrome, transmission mode, diagnosis, treatment, and preventive measures were investigated. 2020-06-06
[Clinical efficacy of Matrine and Sodium Chloride Injection in treatment of 40 cases of COVID-19]. In these cases, patients were treated with other integrated Chinese and Western medicines regimens in the recommended Matrine and Sodium Chloride Injection diagnosis and treatment regimen. 2020-06-08
[Pharmacovigilance study on drug-induced cardiac injury during treatment of COVID-19]. Based on the guideline from the Diagnosis and Treatment Plans for COVID-19(trial seventh edition), taking the recommended drugs as examples, by Western medicine, traditional Chinese medicine, Chinese herbal injection and integrated traditional Chinese and Western medicine, the study analyzed the basic characteristics of recommended drugs for cardiac injury by means of literature review and bioinformatics methods, and summarized cardiac adverse reactions, toxicity mechanisms, combined pharmacotherapy, special population and drug monitoring, focusing on the clinical manifestations, toxic components, targets and regulatory mechanisms of drug-induced cardiac injury. 2020-06-08
[Suggestions on design of evidence-based traditional Chinese medicine clinical study for new public health emergencies]. The scientific study conclusions aim to give feedbacks to clinical diagnosis and treatment regimens. […] It is suggested that scientific experimental design, rigorous collection and scientific data analysis shall be conducted to reflect the therapeutic value of traditional Chinese medicine, so that the study results could be adopted and shared, and become the scientific evidence for China and even the global to republish the diagnosis and treatment regimens. 2020-06-08
Management of COVID-19 Pandemic in Spanish Inflammatory Bowel Disease Units: Results From a National Survey. We conducted a national survey among IBD gastroenterologist members of the Spanish Working Group on Crohn’s Disease and Colitis regarding changes of practice, IBD treatments, and diagnosis and treatment of COVID-19. […] In addition, 7.5% of IBD units made a COVID-19 diagnosis through polymerase chain reaction and/or chest x-ray.Modifications in IBD treatment and treatment recommended for COVID-19 are also discussed. […] We report a representative national survey of changes made in the structure, diagnosis of COVID-19, and modifications in IBD treatments within IBD units. 2020-06-26
Standardized out-patient diagnosis and treatment process for osteoporosis clinics during the COVID-19 pandemic. In an osteoporosis clinic, we advocate the following suggestions to prevent and control osteoporosis during the pandemic period: (1) specialized diagnosis and treatment techniques for osteoporosis patients in the outpatient care, including enhancing the prevention for outpatient medical staff, strengthening awareness of COVID-19 prevention, strictly screening outpatients with COVID-19 infection, and insistent administration of anti-osteoporosis drugs during outbreaks; (2) home prevention for osteoporosis patients including keeping windows open, exposing them to sunlight, supplementing them with enough protein, exercising regularly, and administrating calcium supplements; and (3) simplifying the follow-up and evaluation of osteoporosis using online platforms. 2020-06-10
An update on novel COVID-19 pandemic: a battle between humans and virus. Diagnosis is being carried out by collecting a nasopharyngeal swab or sputum specimen for detection of SARS-CoV-2 RNA by reverse-transcription polymerase chain reaction (RT-PCR). 2020-06-10
COVID-19: a conundrum to decipher. The early diagnosis and management of the disease remains a major challenge. […] In this review, we aim to summarize the updated epidemiology, causes, clinical manifestation and diagnosis, as well as prevention and control of the novel coronavirus SARS-CoV-2. 2020-06-10
Development of an openEHR Template for COVID-19 Based on Clinical Guidelines. A number of studies about disease diagnosis and treatment have been carried out, and many clinically proven effective results have been achieved. […] This issue becomes even more serious if the knowledge for diagnosis and treatment is updated rapidly as is the case for COVID-19. […] This study aims to develop a shared data model based on the openEHR modeling approach to improve the interoperability among systems for the diagnosis and treatment of COVID-19. […] The latest Guideline of COVID-19 Diagnosis and Treatment in China was selected as the knowledge source for modeling. […] First, the guideline was analyzed and the data items used for diagnosis and treatment, and management were extracted. 2020-06-17
SARS-CoV-2 Laboratory Testing in India’s Pandemic Response: A Public Health Perspective. The mainstay of the diagnosis is a reverse-transcription polymerase chain reaction assay to detect SARS-CoV-2 RNA. […] The accurate diagnosis is contingent on appropriate specimen choice, time of collection, and assay employed. […] In this commentary, we highlight the role of laboratory diagnostic tests used in the different stages of India’s COVID-19 pandemic response. 2020-06-17
Early Experience With COVID-19 and Solid Organ Transplantation at a US High-volume Transplant Center. Diagnostic workup, clinical course, immunosuppression/antiviral management and immediate outcomes are described. […] Mean age at diagnosis was 54.8 ± 10.9 years. […] Only 1 mortality (4.8%) to date, in a critically-ill heart/kidney patient who had been in the ICU prior to diagnosis. 2020-06-19
Comparison of the Effectiveness of Different Barrier Enclosure Techniques in Protection of Healthcare Workers During Tracheal Intubation and Extubation. The aim of this study was to compare the effectiveness of different barrier enclosure techniques during tracheal intubation and extubation. 2020-06-09
The effects of blood group types on the risk of COVID-19 infection and its clinical outcome. The aim of this study is to investigate whether there exists a relationship between the blood groups of the patients and risk of SARS-CoV-2 infection and the clinical outcomes in COVID-19 patients. 186 patients with PCR confirmed diagnosis of COVID-19 were included in this study. 2020-06-04
Serodiagnostics for Severe Acute Respiratory Syndrome-Related Coronavirus-2: A Narrative Review. Accurate serologic tests to detect host antibodies to severe acute respiratory syndrome-related coronavirus-2 (SARS-CoV-2) will be critical for the public health response to the coronavirus disease 2019 pandemic. […] Many use cases are envisaged, including complementing molecular methods for diagnosis of active disease and estimating immunity for individuals. 2020-06-20
A Deep Neural Network to Distinguish COVID-19 from other Chest Diseases using X-ray Images. Scanning patient’s lungs to detect a Coronavirus 2019 (COVID-19) may lead to similar imaging with other chest diseases that strongly requires a multidisciplinary approach to confirm the diagnosis. […] There have been few works regarding detection of the coronavirus but there are many cases where it can be misclassified as some techniques do not provide any goodness if it can only identify type of diseases and ignore the rest. 2020-06-04
Maternal and neonatal outcomes associated with COVID-19 infection: A systematic review. RT-PCR was inferior to CT-based diagnosis in 31.7% (26/79) of cases. 2020-06-10
Alterations of the Gut Microbiota in Patients with COVID-19 or H1N1 Influenza. Our study suggests the potential value of the gut microbiota as a diagnostic biomarker and therapeutic target for COVID-19, but further validation is needed. 2020-06-26
Influenza and COVID-19 Co-infection: Report of 6 cases and review of the Literature. All patients with a presumed diagnosis of COVID-19 were routinely screened for influenza. 2020-06-04
COVID-19 presenting with immune thrombocytopenia: a case report and review of the literature. Most probable diagnosis was COVID-19 induced immune thrombocytopenia (ITP) and high dose intravenous immunoglobulin (IVIg) treatment generated a good response. 2020-06-19
NANDA-I, NOC, and NIC Linkages to SARS-Cov-2 (Covid-19): Part 1. Community Response. Then, for each nursing diagnosis, outcomes aligned with all components of the diagnosis were categorized and a list of nursing interventions was selected. […] For the nursing diagnosis Deficient Community Health, eight nursing outcomes and 12 nursing interventions were selected. […] In comparison for the nursing diagnosis, Ineffective Community Coping, nine nursing outcomes and 18 nursing interventions were identified. 2020-06-19
Perspectives on how to navigate cancer surgery in the breast, head and neck, skin, and soft tissue tumor in limited-resource countries during COVID-19 pandemic. Delayed diagnosis, lack of cancer awareness, low adherence to treatment, and unequal or limited access to treatment are among the challenging factors of cancer management in developing countries. 2020-06-26
Evaluation of novel antigen-based rapid detection test for the diagnosis of SARS-CoV-2 in respiratory samples. In the context of the Covid-19 pandemic, the development and validation of rapid and easy-to-perform diagnostic methods are of high priority. […] Diagnostic accuracy was determined in comparison to SARS-CoV-2 real time (RT)-PCR. […] Overall sensitivity and specificity were 93.9% (CI95% 86.5-97.4) and 100% (CI95% 92.1-100), respectively, with a diagnostic accuracy of 96.1% and Kappa coefficient of 0.9. […] The assay has the potential to become an important tool for early diagnosis of SARS-CoV-2, particularly in situations with limited access to molecular methods. 2020-06-06
Coagulopathy in COVID-19 and Its Implication for Safe and Efficacious Thromboprophylaxis. While the risk of venous thromboembolism (VTE) appears to be higher in patients requiring intensive care unit support compared to those admitted to general wards, recent autopsy findings and data on the timing of VTE diagnosis relative to hospitalization clearly suggest that thromboembolic events also contribute to morbidity and mortality in the ambulatory setting. 2020-06-04
Outcomes of COVID-19 among Patients on In-Center Hemodialysis: An Experience from the Epicenter in South Korea. The mean time from symptom onset to diagnosis and admission was 2.6 and 3.5 days, respectively. […] Despite the high-risk conditions associated with worse outcomes, patients on HD did not exhibit extremely poor overall COVID-19 outcomes perhaps due to early diagnosis, prompt hospitalization, and antiviral therapy. 2020-06-05
Immunologic aspects of characteristics, diagnosis, and treatment of coronavirus disease 2019 (COVID-19). Components of immune system, such as antibodies, can also be used to develop sensitive and specific diagnostic methods as well as novel therapeutic agents. […] We also describe the diagnostic methods being used for COVID-19 identification and summarize the current status of various therapeutic strategies, including vaccination, being considered for treatment of the disease. 2020-06-10
Coronavirus Disease 2019: Clinical Review. Diagnosis is based on epidemiological, clinical and imaging features and confirmed by nucleic acid testing. 2020-06-05
ENT management of children with adenotonsillar disease during COVID-19 pandemic. Ready to start again? No homogeneous national health surveillance/screening programs are ongoing or have been conceived to test susceptible population among children/healthcare workers in preparation of coming down to routinely daily activities, and diagnostic strategies are not completely accurate in children. 2020-06-08
COVID-19 pandemic and troponin: indirect myocardial injury, myocardial inflammation or myocarditis? At present, there are limited reports on definite diagnosis of myocarditis caused by SARS-CoV-2 in humans and limited demonstration of the virus in the myocardium. 2020-06-05
Famotidine use and quantitative symptom tracking for COVID-19 in non-hospitalised patients: a case series. Data on demographics, COVID-19 diagnosis, famotidine use, drug-related side effects, temperature measurements, oxygen saturations and symptom scores were obtained using questionnaires and telephone interviews. 2020-06-24
A Comprehensive Review of Severe Acute Respiratory Syndrome Coronavirus 2. In this review, we discuss the background, epidemiology, possible pathophysiology, clinical presentation, and diagnostic studies related to SARS-CoV-2 infection. 2020-06-07
Endoscopic nasopharyngoscopy and ENT specialist safety in the COVID 19 era: the back endoscopy approach to the patient. This manuscript highlights the importance of endoscopy in daily ENT clinical practice, which is a pivotal procedure in the diagnosis of many head and neck pathologies. 2020-06-08
The impact of COVID-19 pandemic in the colorectal cancer prevention. The interruption of CRC prevention may lead to a delayed diagnosis of CRC, possibly in a more advanced stage. 2020-06-08
Chest CT features of coronavirus disease 2019 (COVID-19) pneumonia: key points for radiologists. An early diagnosis of COVID-19 is crucial for disease treatment and control of the disease spread. […] Real-time reverse-transcription polymerase chain reaction (RT-PCR) demonstrated a low sensibility; therefore chest computed tomography (CT) plays a pivotal role not only in the early detection and diagnosis, especially for false negative RT-PCR tests, but also in monitoring the clinical course and in evaluating the disease severity. 2020-06-25
Radiological management of COVID-19: structure your diagnostic path to guarantee a safe path. The current COVID-19 outbreak is requiring a tremendous effort not only regarding the diagnostic and therapeutic approach but also in terms of global management of the delivered care. […] To optimize the diagnostic pathway during the current COVID-19 outbreak, the hospital administration of our tertiary center applied a highly structured framework assigning specific tasks to the different units composing the Department of Imaging. […] In particular, since the beginning of the pandemic, a mobile CT scanner in a truck was rented and became operative for all patients with a confirmed diagnosis of COVID-19 and another CT was assigned for all suspected cases. […] Thus, according to the experience gained in our center, we recommend to all hospital administrations facing the COVID-19 outbreak to promptly adapt their resources, creating precise and safe pathways for their diagnostic units. 2020-06-25
Reduction in skin cancer diagnosis, and overall cancer referrals, during the COVID-19 pandemic. We investigated whether there had been a similar reduction in urgent cancer referrals (known in England as the Two Week Wait (TWW) pathway) and subsequent diagnosis of skin cancer in our dermatology service. 2020-06-19
Frequency of Abnormalities Detected by Point-of-Care Lung Ultrasound in Symptomatic COVID-19 Patients: Systematic Review and Meta-Analysis. Thus, a search for modalities that can expedite and improve the diagnosis and management of this entity is underway. […] Recent data suggested the utility of lung ultrasound (LUS) in the diagnosis of COVID-19 by detecting an interstitial pattern (B-pattern). […] The finding from our review highlights the potential role of this modality in the triage, diagnosis, and follow-up of COVID-19 patients. […] A sizable diagnostic accuracy study comparing LUS, computed tomography scan, and COVID-19-specific tests is warranted to further test this finding and to delineate the diagnostic and prognostic yield of each of these modalities. 2020-06-05
Characteristics and assessment of the usefulness of serological tests in the diagnostic of infections caused by coronavirus SARS-CoV-2 on the basis of available manufacturer’s data and literature review. However, in the laboratory diagnosis of SARS-CoV-2 infections, in addition to genetic tests, serological methods can also be used to detect specific antibodies of the IgM, IgG and IgA class produced after contact with antigens or to detect viral antigen. […] Currently, a number of rapid immunochromatographic, chemiluminescent and ELISA immunoassay tests developed by different manufacturers for the diagnosis of COVID-19 are available on the market. […] Despite this fact, so far there is no WHO or ECDC recommendations or even reliable research regarding the usefulness of serological investigations in the laboratory diagnosis of infections caused by SARS-CoV-2. 2020-06-09
‘Self-collected upper respiratory tract swabs for COVID-19 test’: A feasible way to increase overall testing rate and conserve resources in South Africa. Self-collection of upper respiratory tract specimen for diagnostic purposes is not new. 2020-06-09
Chloroquine dosage regimens in patients with COVID-19: Safety risks and optimization using simulations. The aim of this study is to provide a critical appraisal of the safety information regarding chloroquine treatment and to apply simulation techniques to unveil relationships between the observed serious adverse events and overdosing, as well as to propose optimized dosage regimens. 2020-06-08
What orthopedic surgeons need to know about Covid-19 pandemic. In this article, we provide a brief review for Orthopedic surgeons as regard COVID-19 virus microbiology, epidemiology, clinical picture, and diagnosis. 2020-06-08
SARS-CoV-2 infection serology: a useful tool to overcome lockdown? A lot of serological diagnostic kits have been proposed on the market but validation studies have not been published for many of them. 2020-06-08
A modified deep convolutional neural network for detecting COVID-19 and pneumonia from chest X-ray images based on the concatenation of Xception and ResNet50V2. In this paper, we have trained several deep convolutional networks with introduced training techniques for classifying X-ray images into three classes: normal, pneumonia, and COVID-19, based on two open-source datasets. […] In this research, we introduce some training techniques that help the network learn better when we have an unbalanced dataset (fewer cases of COVID-19 along with more cases from other classes). 2020-06-16
Novel wastewater surveillance strategy for early detection of coronavirus disease 2019 hotspots. The novel coronavirus disease 2019, a pandemic of global concern, caused by the novel severe acute respiratory syndrome coronavirus 2 has severely revealed the need for public monitoring and efficient screening techniques. 2020-06-08
Identification of nsp1 gene as the target of SARS-CoV-2 real-time RT-PCR using nanopore whole-genome sequencing. The diagnostic specificity was 100% (95% CI: 92.9%-100%). 2020-06-19
Closing the Psychological Treatment Gap During the COVID-19 Pandemic With a Supportive Text Messaging Program: Protocol for Implementation and Evaluation. Data analysis will include parametric and nonparametric techniques, focusing on primary outcomes (ie, stress, anxiety, and depressive symptoms) and metrics of use, including the number of subscribers and user satisfaction. 2020-06-23
Incidental CT Findings Suspicious for COVID-19-Associated Pneumonia on Nuclear Medicine Examinations: Recognition and Management Plan. It is critical for nuclear medicine physicians to develop diagnostic skills for timely recognition of typical findings of C-19AP on a localizing CT. 2020-06-22
Melanoma defies ‘lockdown’: ongoing detection during Covid-19 in central London. The COVID-19 pandemic has presented significant challenges for Dermatology services, particularly the diagnosis and management of malignant melanoma (MM). 2020-06-19
Prevention, Diagnosis, and Treatment of VTE in Patients With COVID-19: CHEST Guideline and Expert Panel Report. This recognition has led to the urgent need for practical guidance regarding prevention, diagnosis, and treatment of VTE. […] A group of approved panelists developed key clinical questions by using the PICO (Population, Intervention, Comparator, Outcome) format that addressed urgent clinical questions regarding the prevention, diagnosis, and treatment of VTE in patients with COVID-19. 2020-06-26
New-onset anosmia and ageusia in adult patients diagnosed with SARS-CoV-2 infection. We investigated the prevalence of anosmia and ageusia in adult patients with a laboratory-confirmed diagnosis of infection with severe acute respiratory distress syndrome coronavirus-2 (SARS-CoV-2). 2020-06-25
Comparison of diagnostic accuracies of rapid serological tests and ELISA to molecular diagnostics in patients with suspected coronavirus disease 2019 presenting to the hospital. To assess the diagnostic performance of rapid lateral flow immunochromatographic assays (LFAs) compared with an ELISA and nucleic acid amplification tests (NATs) in individuals with suspected coronavirus disease 2019 (COVID-19). […] There is large variability in diagnostic test performance between rapid LFAs, but overall limited sensitivity and high specificity in acutely admitted patients. 2020-06-12
The Australian response to the COVID-19 pandemic and diabetes - Lessons learned. Reduced access to primary care, diagnostic and hospital services for diabetes, combined with fear of exposure to the virus in these settings, led to a significant drop in access to usual diabetes care. 2020-06-28
Changes in breast cancer management during the Corona Virus Disease 19 pandemic: An international survey of the European Breast Cancer Research Association of Surgical Trialists (EUBREAST). The estimated time interval between diagnosis and treatment initiation increased for about 20% of institutions. 2020-06-26
Continuing versus suspending angiotensin-converting enzyme inhibitors and angiotensin receptor blockers: Impact on adverse outcomes in hospitalized patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)–The BRACE CORONA Trial. Eligible patients using renin-angiotensin system blockers (ACEI/ARBs) with a confirmed diagnosis of COVID-19 will be randomized to a strategy of continued ACEI/ARB treatment versus temporary discontinuation for 30 days. 2020-06-26
A systematic review of neurological manifestations of SARS-CoV-2 infection: the devil is hidden in the details. The authors therefore provide guidance for more careful clinical, diagnostic and epidemiological studies to characterize the manifestations and burden of neurological disease caused by SARS-CoV-2 on behalf of the Infectious Disease Panel of the European Academy of Neurology. 2020-06-19
AI Chatbot Design during an Epidemic Like the Novel Coronavirus. This study presents the design of a sophisticated artificial intelligence (AI) chatbot for the purpose of diagnostic evaluation and recommending immediate measures when patients are exposed to nCOV-19. 2020-06-08
The Mechanism and Clinical Outcome of patients with Corona Virus Disease 2019 Whose Nucleic Acid Test has changed from negative to positive, and the therapeutic efficacy of Favipiravir: A structured summary of a study protocol for a randomised controlled trial. After the first diagnosis and treatment of COVID-19, the nucleic acid test of respiratory specimens such as sputum or nasopharyngeal swabs, has been negative for two consecutive times (sampling time interval of at least 24 hours), in accordance with the COVID-19’s diagnosis and treatment Plan (7th Edition), discharged.3. 2020-06-08
Specific Considerations for Sonographers When Performing Echocardiography during the 2019 Novel Coronavirus Outbreak: Supplement to the American Society of Echocardiography Statement. How to scan addresses the topics of scanning techniques (tailored protocols, right-handed scanning, use of barrier devices) and equipment cleaning and disinfecting. 2020-06-22
Elevation of blood glucose level predicts worse outcomes in hospitalized patients with COVID-19: a retrospective cohort study. Elevation of initial blood glucose level of critical diagnosis was an independent risk factor for in-hospital mortality in critical cases (HR=1.84, 95% CI 1.14 to 2.98, p=0.013). […] Higher median glucose level during hospital stay or after critical diagnosis (≥6.1 mmol/L) was independently associated with increased risks of progression to critical cases/death among non-critical cases, as well as in-hospital mortality in critical cases. 2020-06-19
Tor Vergata University-Hospital in the Beginning of COVID-19-Era: Experience and Recommendation for Breast Cancer Patients. Temporary recommendations are needed that could assist specialists in preventing COVID-19 infection and optimizing resources for diagnosis and treatment of BC patients. 2020-06-22
Indian Association of Gastrointestinal Endo Surgeons COVID-19 endoscopy recommendations. These are recommendations from the Indian Association of Gastro Intestinal Endo Surgeons for safe performance of diagnostic and therapeutic endoscopy during the COVID-19 pandemic. 2020-06-08
Point-of-care lung ultrasound in three neonates with COVID-19. LU was performed bedside by a single investigator at the time of diagnosis and every 48 h during the first week following diagnosis. […] We describe the findings of lung ultrasound monitoring during the first week following diagnosis in three neonates with SARS-CoV-2 infection.What is known:• Lung ultrasound (LU) is a useful tool in COVID-19 management in adults. 2020-06-09
Elevated monocyte distribution width in COVID-19 patients: The contribution of the novel sepsis indicator. An observational study is ongoing at San Donato Hospital with the aim to evaluate the contribution of MDW in the diagnostic pathway in adult patients entering in the ED setting and tested for SARS-CoV-2. 2020-06-27
Detection of SARS-CoV-2 antibodies using commercial assays and seroconversion patterns in hospitalized patients. In this study, we evaluated the performance of six CE-marked point-of-care tests (POC) and three ELISA assays for the diagnosis of COVID-19 by exploring seroconversions in hospitalized patients who tested positive for SARS-CoV-2 RNA. […] To achieve an early diagnosis of COVID-19 based on antibody detection, a dual challenge must be met: the immunodiagnostic window period must be shortened and an optimal specificity must be conserved. 2020-06-19
Implementation of rapid SARS-CoV-2 antigenic testing in a laboratory without access to molecular methods: Experiences of a general hospital. The COVID-19 Ag (Antigen) Respi-Strip assay is a new immunochromatographic diagnostic tool recently available for antigenic diagnosis of SARS-CoV-2. […] The proposed sensitivity is not higher than 60 %, but its high specificity allows both quick decisions for the management of patients and confirmation by molecular diagnosis for only negative tests. […] Over a period of one month, we compared the negative results obtained with the COVID-19 Ag Respi-Strip kit with those obtained from qRT-PCR performed in a laboratory qualified for the molecular diagnosis of SARS-CoV-2. 2020-06-26
Alltest rapid lateral flow immunoassays is reliable in diagnosing SARS-CoV-2 infection from 14 days after symptom onset: A prospective single-center study. SARS-CoV-2 infection diagnosis is challenging in patients from 2 to 3 weeks after the onset of symptoms, due to the low positivity rate of the PCR. […] Serologic tests could be complementary to PCR in these situations. […] The aim of our study was to analyze the diagnostic performance of one serologic rapid test in COVID-19 patients. […] Then, we prospectively evaluated the test in 61 patients with clinical diagnosis of pneumonia of unknown etiology that were negative for SARS-CoV-2 by PCR (group 3). 2020-06-26
COVID-19 and picotechnology: Potential opportunities. This approach, which can be expressed in terms of picotechnology, makes it possible to identify living cell types or in general, chemical and biological surfaces using their atomic arrays, and applied for early diagnosis even treatment of the disease. 2020-06-26
Covid-19 and lung cancer: A greater fatality rate? We also described Covid-19 treatment outcome, mortality and associated risk factors using univariate and multivariate logistic regression analysis. 17/1878 total diagnosis in our center had lung cancer (0.9 %) versus 1878/320,000 of the total reference population (p = 0.09). 9/17 lung cancer patients with Covid-19 diagnosis died (52.3 %) versus 192/1878 Covid-19 patients in our center (p < 0.0001). 2020-06-26
Towards reduction in bias in epidemic curves due to outcome misclassification through Bayesian analysis of time-series of laboratory test results: case study of COVID-19 in Alberta, Canada and Philadelphia, USA. Despite widespread use, the accuracy of the diagnostic test for SARS-CoV-2 infection is poorly understood. […] We examined time-series data of laboratory tests for SARS-CoV-2 viral infection, the causal agent for COVID-19, to try to explore, using a Bayesian approach, the sensitivity and specificity of the diagnostic test. […] The best way to better understand bias in the epidemic curves of COVID-19 due to errors in testing is to empirically evaluate misclassification of diagnosis in clinical settings and apply this knowledge to adjustment of epidemic curves. 2020-06-22
A SARS-CoV-2 familial cluster infection reveals asymptomatic transmission to children. On February 1, 2020, two children(case 1 and case 2), an 8-year-old girl and a 9-year-old boy, were admitted to the isolation ward in Xiangyang Central Hospital, Hubei province, China, with the diagnosis of COVID-19. 2020-06-17
Molecular analysis of several in-house rRT-PCR protocols for SARS-CoV-2 detection in the context of genetic variability of the virus in Colombia. Different in-house real-time RT-PCR (rRT-PCR) methods for SARS-CoV-2 diagnosis and the appearance of genomes with mutations in primer regions have been reported. […] Hence, whole-genome data from locally-circulating SARS-CoV-2 strains contribute to the knowledge of its global variability and the development and fine tuning of diagnostic protocols. […] To describe the genetic variability of Colombian SARS-CoV-2 genomes in hybridization regions of oligonucleotides of the main in-house methods for SARS-CoV-2 detection, RNA samples with confirmed SARS-CoV-2 molecular diagnosis were processed through next-generation sequencing. […] Genetic variability was detected in Colombian SARS-CoV-2 sequences in some of the primer/probe regions for in-house rRT-PCR diagnostic tests available at WHO COVID-19 technical guidelines; its impact on the performance and rates of false-negative results should be experimentally evaluated. […] The genomic surveillance of SARS-CoV-2 is highly recommended for the early identification of mutations in critical regions and to issue recommendations on specific diagnostic tests to ensure the coverage of locally-circulating genetic variants. 2020-06-27
Brief clinical evaluation of six high-throughput SARS-CoV-2 IgG antibody assays. Serological SARS-CoV-2 assays are urgently needed for diagnosis, contact tracing and for epidemiological studies. 2020-06-26
National Clinical Guidance for the Management of Cardiovascular Intervention in the COVID-19 Pandemic: From Bangladesh Society of Cardiovascular Interventions (BSCI). Given its robust capacity for human-to-human transmission and potential of being a nosocomial source of infection, the disease has specific implications on healthcare systems and health care professionals faced with performing essential cardiac procedures in patients with a suspected or confirmed diagnosis of COVID-19. 2020-06-09
Thoracic computerised tomography scans in one hundred eighteen orthopaedic patients during the COVID-19 pandemic: identification of chest lesions; added values; help in managing patients; burden on the computerised tomography scan department. Among the 1397 chest CT scans performed during the pandemic period from 1 March 2020 to 10 May 2020, in two centres with orthopaedic surgery, we selected all the 118 thoracic or chest CT performed for patients who presented to the Emergency Department of the hospital with a diagnosis of trauma for orthopaedic surgical treatment. […] Thirty-nine of these 118 patients were tested with PCR for the diagnosis of COVID-19 infection. 2020-06-11
Long-term intubation and high rate of tracheostomy in COVID-19 patients might determine an unprecedented increase of airway stenoses: a call to action from the European Laryngological Society. A range of prevention strategies, diagnostic work-up, and therapeutic approaches are reported and framed within the COVID-19 pandemic context. 2020-06-11
Management of critically ill patients with COVID-19 in ICU: statement from front-line intensive care experts in Wuhan, China. A comprehensive document with 46 statements are presented, including protection of medical personnel, etiological treatment, diagnosis and treatment of tissue and organ functional impairment, psychological interventions, immunity therapy, nutritional support, and transportation of critically ill COVID-19 patients. 2020-06-11
Hyperacute multi-organ thromboembolic storm in COVID-19: a case report. We report a 66-year-old female patient with post-mortem diagnosis of COVID-19 who presented progressive livedo racemosa, acute renal failure and myocardial injury, as well as an absence of respiratory symptoms. 2020-06-11
Clinical features of COVID-19 convalescent patients with re-positive nucleic acid detection. Increasingly, confirmed patients being discharged according to the current diagnosis and treatment protocols, follow-up of convalescent patients is important to knowing about the outcome. 2020-06-19
Clinical features and outcomes of COVID-19 patients with benign prostatic hyperplasia in ageing male: A retrospective study of 18 cases. Diagnosis was confirmed by COVID-19 nucleic acid test by sampling sputum or nasopharyngeal swab. 2020-06-23
Interpretation of the Traditional Chinese Medicine portion of the diagnosis and treatment protocol for corona virus disease 2019 (Trial Version 7). The TCM protocol in the Diagnosis and Treatment Protocol for corona virus disease 2019 (COVID-19) (Trial Version 7) has been updated from previous versions. 2020-06-22
Impact of the COVID-19 pandemic on patients with pre-existing anxiety disorders attending secondary care. Semi-structured interviews were conducted with 30 individuals attending the Galway-Roscommon Mental Health Services with an ICD-10 diagnosis of an anxiety disorder to determine the impact of the Covid-19 restrictions on anxiety and mood symptoms, social and occupational functioning and quality of life. 2020-06-08
Self-reported anosmia and dysgeusia as key symptoms of coronavirus disease 2019. This evidence can be helpful in the clinical diagnosis of COVID-19, particularly settings of limited testing capacity. 2020-06-25
[Panic and pandemic: Review of the literature on the links between panic disorder and the SARS-CoV-2 epidemic]. The results reviewed here highlight the importance of considering and further investigating the impact of the current pandemic on the diagnosis and treatment of panic disorder (alone or comorbid with the COVID-19). 2020-06-11
A new and rapid approach for detecting COVID-19 based on S1 protein fragments. A colloidal gold immunochromatography assay for IgM/IgG antibodies against the receptor-binding domain of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) S1 protein was established to assess its rapid diagnostic value. 2020-06-08
Can routine laboratory tests discriminate SARS-CoV-2-infected pneumonia from other causes of community-acquired pneumonia? Nine laboratory parameters were identified to be predictive of a diagnosis of COVID-19. […] Routine laboratory examinations may be helpful for the diagnosis of COVID-19. 2020-06-11
Significance of clinical phenomes of patients with COVID-19 infection: A learning from 3795 patients in 80 reports. We summarized clinical phenomes of 3795 patients with COVID-19 based on 80 published reports from the onset of outbreak to March 2020 to emphasize the importance and specificity of those phenomes in diagnosis and treatment of infection, and evaluate the impact on medical services. 2020-06-11
COVID-19: hemoglobin, iron, and hypoxia beyond inflammation. A narrative review. A more comprehensive diagnostic/therapeutic approach to COVID-19 is proposed, including potential adjuvant interventions aimed at improving hemoglobin dysfunction, iron over-deposit and generalized hypoxic state. 2020-06-09
Heart Failure with Preserved Ejection Fraction in a Postpartum Patient with Superimposed Preeclampsia and COVID-19. On presentation she had severe hypertension, pulmonary edema, elevated brain natriuretic peptide, and high-sensitivity troponin-I, suggesting a diagnosis of hypertensive emergency leading to heart failure with a preserved ejection fraction resulting in pulmonary edema and abnormal cardiac screening tests. 2020-06-09
Insights on early mutational events in SARS-CoV-2 virus reveal founder effects across geographical regions. Finally, we firmly urge that primer sets for diagnosis be carefully designed, since rapidly occurring variants would affect the performance of the reverse transcribed quantitative PCR (RT-qPCR) based viral testing. 2020-06-09
COVID-19 target: A specific target for novel coronavirus detection. An ongoing outbreak of pneumonia associated with a novel coronavirus has been reported worldwide and become a global health problem; hence, the diagnosis and differentiation of this virus from other types of coronavirus is essential to control of the disease. 2020-06-09
Editorial: Diagnostic Testing for SARS-Coronavirus-2 in the Nursing Facility: Recommendations of a Delphi Panel of Long-Term Care Clinicians. The panel endorsed facility-wide testing of staff and residents without dissent when diagnostic RT-PCR was available. 2020-06-11
Clinical Presentation of COVID19 in Dementia Patients. Clinical records of each patients admitted to the hospital with a diagnosis of COVID19 infection were retrospectively analyzed. […] Diagnosis of dementia, modalities of onset of the COVID-19 infection, symptoms of presentation at the hospital and outcomes were recorded. […] In a logistic regression model age, and the diagnosis of dementia resulted independently associated with a higher mortality, and patients diagnosed with dementia presented an OR of 1.84 (95% CI: 1.09-3.13, p<0.05). […] The diagnosis of dementia, especially in the most advanced stages, represents an important risk factor for mortality in COVID-19 patients. 2020-06-11
A novel risk score to predict diagnosis with Coronavirus Disease 2019 (COVID-19) in suspected patients: A retrospective, multi-center, observational study. The aim of the study was to explore a novel risk score to predict diagnosis with COVID-19 among all suspected patients at admission. […] We found nine independent risk factors for diagnosis with COVID-19 at admission to hospital: epidemiological exposure histories (OR:13.32, 95%CI 6.39-27.75), weakness/fatigue (OR:4.51, 95%CI 1.70-11.96), heart rate <100 beat/min (OR:3.80, 95%CI 2.00-7.22), bilateral pneumonia (OR:3.60, 95%CI 1.83-7.10), neutrophil count ≤6.3×109 /L (OR: 6.77, 95%CI 2.52-18.19), eosinophil count ≤0.02×109 /L (OR:3.14, 95%CI 1.58-6.22), glucose ≥6 mmol/L (OR:2.43, 95%CI 1.04-5.66), D-dimer ≥0.5 mg/L (OR:3.49, 95%CI 1.22-9.96), and C-reactive protein <5 mg/L (OR:3.83, 95%CI 1.86-7.92). […] We designed a novel risk score which might have a promising predictive capacity for diagnosis with COVID-19 among suspected patients. 2020-06-19
Clinical performance of different SARS-CoV-2 IgG antibody tests. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) serological assays are urgently needed for rapid diagnosis, contact tracing, and for epidemiological studies. 2020-06-24
Diagnostic methods and potential portable biosensors for coronavirus disease 2019. Timely detection and diagnosis are urgently needed to guide epidemiological measures, infection control, antiviral treatment, and vaccine research. […] In this review, biomarkers/indicators for diagnosis of coronavirus disease 2019 (COVID-19) or detection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in the environment are summarized and discussed. […] However, antibody detection methods can be combined with quantitative real-time reverse transcriptase-polymerase chain reaction (RT-qPCR) to significantly improve the sensitivity and specificity of diagnosis, and boost vaccine research. […] Various specimens for diagnosis or detection are compared and analyzed. […] Chest computerized tomography (CT) scan, RT-qPCR, lateral flow immunochromatographic strip (LFICS) for diagnosis of COVID-19 are summarized and compared. […] Specially, potential electrochemical (EC) biosensor, surface enhanced Raman scattering (SERS)-based biosensor, field-effect transistor (FET)-based biosensor, surface plasmon resonance (SPR)-based biosensor and artificial intelligence (AI) assisted diagnosis of COVID-19 are emphasized. 2020-06-23
Perceptions of obstetricians and pediatricians about the risk of COVID-19 for pregnant women and newborns. Participants were well informed about the symptoms, diagnosis, modes of transmission, and methods of prevention. 2020-06-26
SARS-COV-2 and Male Reproductive Health. We will further describe its mechanism of action, diagnosis, symptoms, and potential effects on the male reproductive system. 2020-06-08
The Laboratory Diagnosis of COVID-19– Frequently-Asked Questions. Diagnostic testing has played and will continue to play a major role in the COVID-19 pandemic. […] Here we discuss questions commonly asked by clinicians about COVID-19 diagnostic testing. 2020-06-26
Diagnosis and management of the drug hypersensitivity reactions in Coronavirus disease 19. There is no knowledge about the diagnosis and clinical management of the drug hypersensitivity reactions that can potentially occur during the disease. […] This review brings togetherall the published information about the diagnosis and management of drug hypersensitivity reactions due to current and candidate off-label drugs andhighlights relevant recommendations. […] Furthermore, it gathers all the dermatologic manifestations reported during the disease for guiding the clinicians to establish a better differential diagnosis of drug hypersensitivity reactionsin the course of the disease. 2020-06-19
Management of primary hepatic malignancies during the COVID-19 pandemic: recommendations for risk mitigation from a multidisciplinary perspective. We also review the multidisciplinary management of intrahepatic cholangiocarcinoma as a potentially curable and incurable diagnosis in the setting of COVID-19. 2020-06-11
Comparative analysis of laboratory indexes of severe and non-severe patients infected with COVID-19. The characteristics of laboratory findings of coronavirus are of great significance for clinical diagnosis and treatment. 2020-06-27
Use of Tracheostomy During the COVID-19 Pandemic: CHEST/AABIP/AIPPD: Expert Panel Report. To reduce the risk of infection in HCW, we recommend performing the procedure using techniques that minimize aerosolization while wearing enhanced personal protective equipment (PPE). 2020-06-11
Acute myocardial injury in patients hospitalized with COVID-19 infection: A review. Cardiac biomarkers can be used to aid in diagnosis as well as risk stratification. 2020-06-11
An approach towards development of monoclonal IgY antibodies against SARS CoV-2 spike protein (S) using phage display method: A review. The present state of diagnostic and therapeutic developmental race for vaccines against the SARS CoV-2 (nCOVID-19) focuses on prevention and control of this global pandemic which also represents a critical challenge to the global health community. […] In this review, we discuss the strategies for the use of chicken egg yolk (IgY) antibodies in the development of rapid diagnosis and immunotherapy against SARS CoV-2. 2020-06-23
Evaluation of rapid diagnosis of novel coronavirus disease (COVID-19) using loop-mediated isothermal amplification. RT-LAMP could be a simple and easy-to-use diagnostic tool for the detection of SARS-CoV-2. 2020-06-26
Epidemiological characteristics of and containment measures for COVID-19 in Busan, Korea. Regarding symptoms at the time of diagnosis, cough (n=38, 35.2%) and fever (n=34, 31.5%) were most common; 12 cases (11.1%) were asymptomatic. 2020-06-09
Public Health Emergency and Crisis Management: Case Study of SARS-CoV-2 Outbreak. Arrays of measures in South Korea, such as large-scale diagnostic testing and technology-based comprehensive contact tracing, have brought about debates among public health experts and medical professionals. 2020-06-12
The SARS-CoV-2 Ivermectin Navarra-ISGlobal Trial (SAINT) to Evaluate the Potential of Ivermectin to Reduce COVID-19 Transmission in low risk, non-severe COVID-19 patients in the first 48 hours after symptoms onset: A structured summary of a study protocol for a randomized control pilot trial. Positive IgG against SARS-CoV-2 by rapid diagnostic test. 2020-06-11
Estimated Effect of COVID-19 Lockdown on Skin Tumor Size and Survival: An Exponential Growth Model. In the absence of adequate diagnosis and treatment of SCC and melanoma in the current lockdown situation in Spain, we can expect to see to a considerable increase in large and thick SCCs and melanomas. 2020-06-12
Abdominal pain in a patient with COVID-19 infection: A case of multiple thromboemboli. The novel coronavirus SARS-CoV-2 (COVID-19) pandemic has created diagnostic uncertainty with regards to distinguishing this infection from pulmonary embolism (PE). 2020-06-12
Amid COVID-19 pandemic: Challenges with access to care for COPD patients. In clinical practice, comprehensive care for COPD patients includes the diagnosis using spirometry, clinical examination and comprehensive pharmacological and non-pharmacological management. […] The diagnosis is based on symptoms, dyspnea and lung function impairment and can be mild to very severe. 2020-06-12
In vitro diagnostics of coronavirus disease 2019: Technologies and application. Laboratory-based diagnostic measures including virological and serological tests are essential for detecting severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). […] Serological diagnosis of coronavirus disease 2019 (COVID-19) is simple and does not require complex techniques and equipment, rendering it suitable for rapid detection and massive screening. […] Balancing the increased use of laboratory tests, risk of testing errors, need for tests, burden on healthcare systems, benefits of early diagnosis, and risk of unnecessary exposure is a significant and persistent challenge in diagnosing COVID-19. 2020-06-11
Clinical Performance of SARS-CoV-2 Molecular Testing. Molecular testing for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the gold standard for diagnosis of coronavirus disease 2019 (COVID-19), but the clinical performance of these tests is still poorly understood, particularly with regard to disease course, patient-specific factors, and viral shedding. 2020-06-09
Performance Characteristics of Four High-Throughput Immunoassays for Detection of IgG Antibodies against SARS-CoV-2. Here, we evaluated four high throughput serologic tests for detection of anti-SARS-CoV-2 IgG antibodies, including assays from Abbott Laboratories (Abbott Park, IL), Epitope Diagnostics Inc. […] With the unprecedented influx of commercially available serologic tests for detection of antibodies against SARS-CoV-2, it remains imperative that laboratories thoroughly evaluate such assays for accuracy prior to implementation. 2020-06-09
COVID-19 infection: the China and Italy perspectives. Here, we update the recent understanding in clinical characteristics, diagnosis strategies, as well as clinical management of COVID-19 in China as compared to Italy, with the purpose to integrate the China experience with the global efforts to outline references for prevention, basic research, treatment as well as final control of the disease. 2020-06-26
An overview on COVID-19: reality and expectation. So, there is a rapid need for disease diagnosis, vaccine development, and drug discovery to detect, prevent, and treat this sudden and lethal virus. […] Real-time polymerase chain reaction (RT-PCR) is considered as a rapid, accurate, and specific tool for disease diagnosis. 2020-06-11
Safe distance, safe patients! Therapeutic management of oncological patients affected by cutaneous and mucosal adverse events during the COVID-19 pandemic: an Italian experience. Firstly because of the differential diagnosis of cutaneous rash (e.g., drug-related rash or paraviral exanthema). 2020-06-12
The systemic sclerosis patient in the COVID-19 era: the challenging crossroad between immunosuppression, differential diagnosis and long-term psychological distress. Therefore, the challenge in everyday life will be to achieve in due time the differential diagnosis as well as the long-term psychological impact.Key Points• SSc patients should be encouraged to continue their chronic therapy; in case of immunosuppressive therapy it must be discontinued for safety in case of COVID-19 infection. 2020-06-24
Severity and risk of COVID-19 in cancer patients: An evidence based learning. Immunosuppression can expose cancer patients to serious complications which can lead to delay in diagnosis and unnecessary hospitalizations that may adversely affect the prognosis of the disease. 2020-06-19
COVID-19 in recent kidney transplant recipients. They had minimal symptoms at diagnosis and did not develop any respiratory complications or allograft dysfunction. 2020-06-28
The Microbiology of Coronaviruses. Polymerase chain reaction (PCR) is the diagnostic test of choice in this pandemic situation. 2020-06-18
Application of Biosafety Principles in Laboratory Analysis of Clinical Samples from Patients with COVID-19. COVID-19 poses a great challenge to clinical and diagnostic services around the world. […] Risk assessment must be carried out before meeting up the diagnostic challenge for COVID-19 and essential biorisk management measures are required to be taken. 2020-06-18
Clinical tools for cardiorespiratory assessment and rehabilitation: A primary care perspective. Hence, cardiorespiratory assessment is an important component of diagnosis, management and follow-up of this disease. 2020-06-18
Cardiovigilance in COVID 19. Cardiac dysfunction has been identified as a risk factor, a prognostic factor, a diagnostic tool, differential diagnosis, a complication of COVID 19, and a side effect of its treatment. 2020-06-18
Radiology of COVID-19 - Imaging the pulmonary damage. This document is a brief commentary of the imaging modalities used in the screening, diagnosis and management of COVID-19 pneumonia. 2020-06-18
COVID-19 in children: Epidemiology, presentation, diagnosis and management. Standardised guidelines from initial studies are now available for diagnosis, treatment, and prevention. […] Research should now focus on early diagnosis, better drugs for children, intensive care modalities, and a universal vaccine. 2020-06-18
Guidance for anticoagulation management in venous thromboembolism during the coronavirus disease 2019 pandemic in Poland: an expert opinion of the Section on Pulmonary Circulation of the Polish Cardiac Society. In patients with COVID-19 who are suspected of VTE or in whom the diagnosis is confirmed, parenteral therapy with low-molecular-weight heparin should be initiated in the absence of contraindications. 2020-06-26
Dynamic surveillance of SARS-CoV-2 shedding and neutralizing antibody in children with COVID-19. In children, nasopharyngeal swabs appear to be a more sensitive specimen type for the diagnosis of COVID-19 compared with oropharyngeal swabs. […] The results of this study provide valuable information for the diagnosis and surveillance of COVID-19 and development of SARS-CoV-2 vaccines for use in children. 2020-06-12
Pleural Effusion as a Sign of Coronavirus Disease 2019 (COVID-19) Pneumonia: A Case Report. Early diagnosis of atypical cases of COVID-19 infection is critical in reducing the transmission and controlling the present pandemic. […] In the present report, we described a patient with the chief complaints of dyspnea and dry cough referred to the oncology center at Imam Khomeini Hospital, Tehran with the differential diagnosis of lung cancer who was diagnosed and treated for COVID-19 infection in follow up. […] The patient had been referred to this center with the differential diagnosis of lung cancer due to the massive pleural effusion in initial chest CT scan. 2020-06-09
Rates of Maternal and Perinatal Mortality and Vertical Transmission in Pregnancies Complicated by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-Co-V-2) Infection: A Systematic Review. Inclusion criteria were pregnant women with a confirmed diagnosis of SARS-CoV-2 infection. 2020-06-09
Universal Testing for COVID-19 in Essential Orthopaedic Surgery Reveals a High Percentage of Asymptomatic Infections. Diagnostic Level IV. 2020-06-10
Additive treatment considerations in COVID-19 - the clinician´s perspective on extracorporeal adjunctive purification techniques. Multiple therapeutic strategies, including antibody therapies (such as Tocilizumab, Sarilumab, Siltuximab), therapeutic plasma exchange (TPE), and blood purification techniques for direct removal of cytokines, including filtration, dialysis (diffusion), and adsorption are available. 2020-06-19
Cancer and COVID-19: Unmasking their ties. It has forced oncologists to rethink the entire diagnostic and therapeutic process, based on the local prevalence and impact of COVID-19. […] In this review we will discuss the impact of COVID-19 on patients affected by cancer, their diagnosis and management, as well as the pathophysiology of COVID-19 induced acute respiratory distress symptoms and currently investigated treatment approaches. 2020-06-19
Evaluation of the commercially available LightMix® Modular E-gene kit using clinical and proficiency testing specimens for SARS-CoV-2 detection. Rapid and sensitive diagnostic assays for SARS-CoV-2 detection are required for prompt patient management and infection control. […] A total of 289 clinical specimens from 186 patients with suspected COVID-19 and 8 proficiency testing (PT) samples were used to evaluate the diagnostic performance of the LightMix® E-gene kit against in-house developed COVID-19-RdRp/Hel and COVID-19-N RT-PCR assays. 2020-06-26
Risks to healthcare workers following tracheal intubation of patients with COVID-19: a prospective international multicentre cohort study. The primary endpoint was the incidence of laboratory-confirmed COVID-19 diagnosis or new symptoms requiring self-isolation or hospitalisation after a tracheal intubation episode. 2020-06-19
Low-Contact & High-Interconnectivity Pathology (LC&HI Path): Post-COVID19-Pandemic Practice of Pathology. The challenge is to define the next generation of interconnectivity tools that would be necessary to achieve a new operational model that, while ensuring low face-to-face interaction between the main players of the diagnostic pipeline, allows maximum interconnectivity to serve our patients and the immediate teaching and research needs associated with clinical tissue/cellular samples. 2020-06-19
Azole-Resistant COVID-19-Associated Pulmonary Aspergillosis in an Immunocompetent Host: A Case Report. Delays in diagnosis contribute to a delayed start of antifungal therapy. […] We underline the challenges faced in the management of these cases, the importance of early diagnosis and need for surveillance given the emergence of triazole resistance. 2020-06-11
Impact of Spanish Public Health Measures on Emergency Visits and COVID- 19 diagnosed cases during the pandemic in Madrid. The variability of case definitions and diagnostic test criteria may have impact on the number of emergency visits and COVID-19 diagnosed cases in Emergency Department. 2020-06-10
COVID-19, Australia: Epidemiology Report 17 (Fortnightly reporting period ending 24 May 2020). In addition, the median number of days between symptom onset and diagnostic testing has improved considerably from 7 days in the early phase of the outbreak to 1 day in the latest phase of the epidemic. 2020-06-11
Histopathology of COVID-19 pneumonia in two non-oncological, non-hospitalised cases as a reliable diagnostic benchmark. The results provide a valid diagnostic benchmark for evaluating the evolution of COVID-19 pneumonia. 2020-06-17
Delayed Recognition of Community Transmission of COVID-19 Resulting in Healthcare Worker Infections. We describe a case of delayed COVID-19 diagnosis due to unrecognized community transmission in Atlanta, Georgia in mid-February 2020. […] This case resulted in transmission of COVID-19 to three of the four healthcare workers present during a diagnostic bronchoscopy procedure where only procedural masks were worn. 2020-06-10
Guillain-Barré syndrome: The first documented COVID-19-triggered autoimmune neurologic disease: More to come with myositis in the offing. Anosmia, ageusia, other cranial neuropathies and lymphocytopenia are red flags enhancing early diagnostic suspicion. […] Emerging data indicate that COVID-19 can trigger not only GBS but other autoimmune neurological diseases necessitating vigilance for early diagnosis and therapy initiation. 2020-06-25
Race for a vaccine. With the coronavirus pandemic getting worse, we are turning to new techniques to deliver a vaccine in record time. 2020-06-11
A snapshot of the ongoing clinical research on COVID-19. The pandemic of coronavirus disease 2019 (COVID-19) presents an unprecedented challenge to rapidly develop new diagnostic, preventive and therapeutic strategies. […] In the COVID-19 pandemic era, it is crucial that the adoption of new diagnostic, preventive and therapeutic strategies is based upon evidence coming from well-designed, adequately powered and carefully conducted clinical trials. 2020-06-17
Disaster risk reduction in conflict contexts: Lessons learned from the lived experiences of Rohingya refugees in Cox’s Bazar, Bangladesh. A mixed-methods research strategy incorporating both quantitative household questionnaire survey and qualitative focus group discussions (FGDs) techniques were applied. 2020-06-12
Correlation Between Chest CT Findings and Clinical Features of 211 COVID-19 Suspected Patients in Wuhan, China. Chest CT has a high sensitivity in patients with COVID-19, and it can improve diagnostic accuracy for COVID-19 suspected patients with fever during the initial screen, whereas its value for nonfever patients remains questionable. 2020-06-11
Early chest CT features of patients with 2019 novel coronavirus (COVID-19) pneumonia: relationship to diagnosis and prognosis. Chest CT plays a crucial role in the early diagnosis of COVID-19, particularly for those patients with a negative RT-PCR. […] • Chest CT is valuable for the early diagnosis of COVID-19, particularly for those patients with a negative RT-PCR. 2020-06-13
Coronavirus disease 2019 (COVID-19) pneumonia incidentally detected on coronary CT angiogram: a do-not-miss diagnosis. In addition, with the ongoing outbreak of COVID-19 and exponentially increasing incidence throughout the world, this report stresses the need for including NCIP in the differential diagnosis of patients with typical image findings in at-risk populations, as early diagnosis is crucial for appropriate patient management and post-exposure recommendations. 2020-06-13
Use of a portable computed tomography scanner for chest imaging of COVID-19 patients in the urgent care at a tertiary cancer center. Despite the technical limitations of the portable CT unit that was repurposed for the UCC, diagnostic-quality images in an acute care setting were successfully obtained. […] Repurposing of a portable CT scanner for use in COVID-19 patients offers a feasible option to obtain diagnostic quality images while minimizing the risk of exposing other patients and hospital staff to an infected patient. 2020-06-12
Prolonged SARS-CoV-2 shedding and mild course of COVID-19 in a patient after recent heart transplantation. After diagnosis, immunosuppression was continued unchanged. 2020-06-19
Validity of teleneuropsychology for older adults in response to COVID-19: A systematic and critical review. Combined with nine articles from Brearly’s analysis, a total of 19 studies were included in the systematic review.Results: Retained studies included samples from 5 different countries, various ethnic/cultural backgrounds, and diverse diagnostic populations. 2020-06-10
Coronavirus Disease (COVID-19) in Kidney and Liver Transplant Patients: A Single-Center Experience. We retrospectively evaluated demographic characteristics, currently used immunosuppressant treatment, present complaints, treatment and diagnosis of comorbid diseases, and results of COVID-19 tests. 2020-06-24
Diagnosis of COVID-19 pneumonia despite missing detection of viral nucleic acid and initially inconspicuous radiologic findings. The diagnosis of coronavirus disease 2019 (COVID-19) is mainly based on a positive severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) polymerase chain reaction (PCR) result. 2020-06-24
Pulmonary Capillary Leak Syndrome following COVID-19 Virus Infection. The diagnosis of non-cardiogenic pulmonary edema due to pulmonary capillary leak syndrome SARS-CoV-2 virus infection was obtained by a medical committee of 6 physicians. […] The diagnosis of COVID-19 infection is confirmed by reverse transcription polymerase chain reaction (RT-PCR) test. 2020-06-19
What we know so far about Coronavirus Disease 2019 in children: A meta-analysis of 551 laboratory-confirmed cases. The diagnosis is generally suspected from history of household exposure to COVID-19 case. 2020-06-19
Toward Nanotechnology-Enabled Approaches against the COVID-19 Pandemic. The COVID-19 outbreak has fueled a global demand for effective diagnosis and treatment as well as mitigation of the spread of infection, all through large-scale approaches such as specific alternative antiviral methods and classical disinfection protocols. 2020-06-26
Epidemiology, diagnosis, treatment, and future perspectives concerning SARS-COV-2: a review article. The present study aimed to review the epidemiology, clinical manifestation, laboratory diagnosis, treatment, and future perspectives related to COVID-19 infections. 2020-06-15
Linking Statistics With Testing Policy to Manage COVID-19 in the Community. While the contributions of diagnostic testing for SARS-CoV-2 have received considerable attention, concerns abound regarding the availability of sufficient testing capacity to meet demand. […] Our clinical laboratory and diagnostic infrastructure are capable of incorporating required volumes for many local, regional, and national public health surveillance studies into their current and projected testing capacity. 2020-06-26
Extrapulmonary and atypical clinical presentations of COVID-19. Lack of awareness of these presentations might lead to misdiagnosis, delayed diagnosis and isolation of suspected patients which increases the risk of transmission of infection between patients and doctors. 2020-06-19
The association of lung ultrasound images with COVID-19 infection in an emergency room cohort. We developed a predictive model for COVID-19 diagnosis based on lung ultrasound and clinical features. […] The characteristics (95%CI) of the model’s diagnostic threshold, applied to the population from which it was derived, were: sensitivity, 97% (83-100%); specificity, 62% (50-74%); positive predictive value, 54% (41-98%); and negative predictive value, 98% (88-99%). 2020-06-19
COVID-19 Pneumonia Mimicking Immunotherapy-Induced Pneumonitis on 18F-FDG PET/CT in a Patient Under Treatment With Nivolumab. However, early diagnosis may be challenging, especially in cancer patients under treatment with immunotherapy as drug-induced pneumonitis can present similar clinical and radiological features. 2020-06-19
COVID-19: Incidental Diagnosis by 18F-FDG PET/CT. Real-time polymerase chain reaction testing of nasopharyngeal swabs confirmed the diagnosis. 2020-06-19
Diagnostic Ultrasound Services During the Coronavirus Disease (COVID-19) Pandemic. With increasing use of point-of-care and portable diagnostic US services, the risk is substantial. CONCLUSION. Our experience and protocols may help service providers with their own effective response against COVID-19. 2020-06-10
Overview of Coronavirus Disease 2019 (COVID-19): Treatment Updates and Advances. This review introduces current understanding of SARS-CoV-2 infection and treatment strategies, emphasizing the relevant challenges associated with prevention, diagnosis, and management. 2020-06-10
Review of Chest Radiograph Findings of COVID-19 Pneumonia and Suggested Reporting Language. The diagnosis of coronavirus disease 2019 (COVID-19) is confirmed by reverse transcription polymerase chain reaction. […] With this need for consistency, we propose language for standardized CXR reporting and severity assessment of persons under investigation for having COVID-19, patients with a confirmed diagnosis of COVID-19, and patients who may have radiographic findings typical or suggestive of COVID-19 when the diagnosis is not suspected clinically. […] In addition, we summarize the currently available literature related to the use of CXR for COVID-19 and discuss the evolving techniques of obtaining CXR in COVID-19-positive patients. 2020-06-10
Clinical Analysis of 25 COVID-19 Infections in Children. The diagnosis was confirmed through RNA-PCR testing. […] RNA-PCR test is still the most reliable diagnostic method, especially for asymptomatic patients. 2020-06-26
COVID-19 in Lung Transplant Recipients. Management of lung transplant recipients can be particularly challenging given high levels of maintenance immunosuppression, high incidence of rejection, constant exposure of the graft to the external environment, and diagnostic uncertainty in patients with respiratory symptoms. 2020-06-19
[Expert consensus on Corona Virus Disease 2019 with special blood purification technology]. It was indicated in the diagnosis and treatment scheme, by the National Health Commission of the People’s Republic of China, that blood purifications such as plasma exchange, plasma adsorption, hemoperfusion, hemofiltration and plasmafiltration could be considered for use in the critical patients with cytokine storm syndrome. 2020-06-10
COVID-19 and Congenital Heart Disease: Results from a Nationwide Survey. COVID-19 diagnosis was defined as either “clinically suspected” or “confirmed”, where a severe acute respiratory syndrome coronavirus 2 (SARS-CoV2) test had been performed and was positive. 2020-06-11
Evaluation of Chemical Protocols for Inactivating SARS-CoV-2 Infectious Samples. Clinical samples collected in coronavirus disease 19 (COVID-19), patients are commonly manipulated in biosafety level 2 laboratories for molecular diagnostic purposes. 2020-06-17
[Experts consensus for the diagnosis, treatment, and prevention of Coronavirus disease 2019 in the elderly]. To improve the diagnosis, treatment, and prevention of COVID-19 in the elderly, the Expert Committee of Geriatric Respiratory and Critical Care Medicine, China Society of Geriatrics established the “Expert consensus for the diagnosis, treatment, and prevention of Coronavirus disease 2019 in the elderly” . […] (1) For diagnosis, atypical clinical presentation of COVID-19 in the elderly should be emphasized, which may be complicated by underlying disease. 2020-06-11
Autophagy as an emerging target for COVID-19: lessons from an old friend, chloroquine. Still, much information is not known, including origin of the disease, complete genomic characterization, mechanism of transmission dynamics, extent of spread, possible genetic predisposition, clinical and biological diagnosis, complete details of disease-induced pathogenicity, and possible therapeutic options. 2020-06-24
Laboratory Biosafety Considerations of SARS-CoV-2 at Biosafety Level 2. In China, diagnostic tests and laboratory tests of specimens from persons under investigation are usually performed in a biosafety level 2 environment. 2020-06-22
COVID-19, Australia: Epidemiology Report 16 (Reporting week to 23:59 AEST 17 May 2020). Although some low-income countries have so far reported few cases, it is possible that this is due to limited diagnostic and public health capacity, and may not be reflective of true disease incidence. 2020-06-11
COVID-19: viral-host interactome analyzed by network based-approach model to study pathogenesis of SARS-CoV-2 infection. The resulting pattern may facilitate the process of structure-guided pharmaceutical and diagnostic research with the prospect to identify potential new biological targets. 2020-06-23
Risk management-based security evaluation model for telemedicine systems. This research should be beneficial to security experts who wish to investigate the impacts of cybersecurity threats on remote healthcare and researchers who wish to identify new modeling opportunities to apply security risk modeling techniques. 2020-06-17
Proactive Prophylaxis With Azithromycin and HydroxyChloroquine in Hospitalised Patients With COVID-19 (ProPAC-COVID): A structured summary of a study protocol for a randomised controlled trial. • Patient admitted to Danish emergency departments, respiratory medicine departments or internal medicine departments • Age≥ 18 years • Hospitalized ≤48 hours • Positive COVID-19 test / diagnosis during the hospitalization (confirmed). 2020-06-17
South Korea’s Reponses to Stop the COVID-19 Pandemic. As a result, COVID-19 diagnostic test kits were quickly developed, enabling extensive early detection of potential cases. 2020-06-11
COVID-19: to be or not to be; that is the diagnostic question. The dual-process model of clinical reasoning is used to analyse the thought processes used to make a diagnosis of COVID-19, including consideration of the variety of differential diagnoses.While SARS-CoV-2 is likely to remain on the differential diagnostic list for a plethora of presentations for the foreseeable future, clinicians should be cautious of ignoring other potential diagnoses due to availability bias. […] A knowledge of infectious mimics prevents COVID-19 from overshadowing other diagnoses, hence preventing delayed diagnosis or even misdiagnosis and consequent adverse outcomes for patients. 2020-06-25
Genomic determinants of pathogenicity in SARS-CoV-2 and other human coronaviruses. Using integrated comparative genomics and machine learning techniques, we identify key genomic features that differentiate SARS-CoV-2 and the viruses behind the two previous deadly coronavirus outbreaks, SARS-CoV and Middle East respiratory syndrome coronavirus (MERS-CoV), from less pathogenic coronaviruses. 2020-06-11
Impact of COVID-19 on reperfusion strategies for acute coronary syndromes. Reperfusion therapy is a measure of care in patients with ST-elevation myocardial infarction (STEMI), which should be performed once we have the diagnosis. 2020-06-23
The SARS-CoV-2 (COVID-19) coronavirus pandemic: current situation and implications for Mexico. The low number of diagnostic tests conducted in our country clearly underestimates the real incidence and impact of the disease. 2020-06-23
A quantitative and qualitative analysis of the COVID-19 pandemic model. Also, the local sensitivities for each model state concerning the model parameters are computed using three different techniques: non-normalizations, half normalizations, and full normalizations. 2020-06-12
Challenges and strategies in management of osteoporosis and fragility fracture care during COVID-19 pandemic. Access to diagnostic tests, treatment facilities with the need to use clinical and prediction tools to guide management Telemedicine has an evolving role. […] Osteoporosis and fragility fractures in elderly individuals pose a real challenge for an appropriate diagnosis and management, during the COVID-19 pandemic. 2020-06-12
Understanding the current status of patients with pulmonary hypertension during COVID-19 outbreak: a small-scale national survey from China. A questionnaire regarding the living condition of pulmonary hypertension patients during coronavirus disease 2019 was designed by pulmonary hypertension diagnostic experts in Wuhan Asia Heart Hospital. 2020-06-12
Acute Pericarditis and Cardiac Tamponade in a Patient with COVID-19: A Therapeutic Challenge. We also discuss complications associated with delayed diagnosis in patients who potentially may need mechanical ventilation. 2020-06-12
Pericardial Fluid in a COVID-19 Patient: Is It Exudate or Transudate? We hope our data provide additional insight into the diagnosis and therapeutic options for managing this infection.LEARNING POINTS: Laboratory findings of drained pericardial fluid in a patient with COVID-19 are presented.The clinical presentation of pericardial involvement in COVID-19 infection and the role of echocardiography in diagnosis and management are described. 2020-06-12
Stress Cardiomyopathy in COVID-19 Disease. One of them died, while in the other two coronary angiography confirmed the diagnosis but was postponed until after pneumonia resolution because of the risk of virus spread. 2020-06-12
D-dimer and C-reactive Protein Blood Levels Over Time Used to Predict Pulmonary Embolism in Two COVID-19 Patients. The diagnosis of pulmonary embolism is challenging in symptomatic COVID-19 patients since shortness of breath, chest pain, tachycardia, tachypnoea, fever, oxygen desaturation and high D-dimer blood levels might be features of both diseases. […] The diagnosis of pulmonary embolism is challenging in COVID-19 patients since symptoms, signs and high D-dimer blood levels might be similar in both diseases.An increase in D-dimer blood levels and a decrease in C-reactive protein blood levels over time may be used as a novel method to predict pulmonary embolism in COVID-19 patients. 2020-06-12
Effectiveness of Tocilizumab in a COVID-19 Patient with Cytokine Release Syndrome. CRS in patients with coronavirus disease 2019 (COVID-19) is life-threatening and can occur very rapidly after COVID-19 diagnosis. 2020-06-12
Fatal Ischaemic Stroke During COVID-19 and Acute Lung Injury. Deep sedation may delay diagnosis. […] Prolonged deep sedation during mechanical ventilation of COVID-19 patients may delay the diagnosis of stroke.The hypercoagulability and a thrombo-inflammatory response in COVID-19 is characterized by an increase in D-dimers and fibrinogen. 2020-06-12
Should the Management of Embolic Stroke in the Elderly Be Changed if They Also Have COVID-19? The diagnosis of embolic stroke (namely, total anterior circulation infarct; TACI) was made. […] During hospitalization, new embolic events occurred and a concomitant diagnosis of COVID-19 was made with progressive respiratory dysfunction followed by multiorgan failure. […] The diagnosis of COVID-19 contributed to the patient’s death. 2020-06-12
Diaphragmatic Rupture and Gastric Perforation in a Patient with COVID-19 Pneumonia. A diagnosis of diaphragmatic rupture and gastric perforation in COVID-19 pneumonia was made. 2020-06-12
What patients “see” doctors in online fever clinics during COVID-19 in Wuhan? From the 594 patient questions analyzed, confirming diagnosis and seeking medical treatment account for 60.61% and 38.05%, respectively, followed by treating (25.59%), preventing (4.38%), and relieving anxiety (1.68%). 2020-06-26
Recommendations of protective measures for orthopedic surgeons during COVID-19 pandemic. The appropriate protective measures for orthopedic surgeons and patients were reviewed (on-site first aid, emergency room, operating room, isolation wards, general ward, etc.) during the entire diagnosis and treatment process of traumatic patients. […] Lessons learnt from our experience provide some recommendations of protective measures during the entire diagnosis and treatment process of traumatic patients and help others to manage orthopedic patients with COVID-19, to reduce the risk of cross-infection between patients and to protect healthcare workers during work. 2020-06-13
Assessing the spreading potential of an undetected case of COVID-19 in orthopaedic surgery. All HCW with exposure to the patient from day of admission until confirmed diagnosis of COVID-19 were identified and underwent oropharyngeal swab testing for SARS-CoV-2 by real-time RT-PCR. 2020-06-13
Covid-19: automatic detection from X-ray images utilizing transfer learning with convolutional neural networks. Since by now, all diagnostic tests show failure rates such as to raise concerns, the probability of incorporating X-rays into the diagnosis of the disease could be assessed by the medical community, based on the findings, while more research to evaluate the X-ray approach from different aspects may be conducted. 2020-06-17
Infection Control and Management Strategy for COVID-19 in the Radiology Department: Focusing on Experiences from China. Radiological examinations play a crucial role in the early diagnosis and follow-up of COVID-19. 2020-06-19
Case report: COVID-19 Masquerading as an Acute Surgical Abdomen. These atypical and rare presentations may lead to difficulties in establishing the diagnosis in a timely manner; furthermore, they may lead to unnecessary investigations, extended hospital stays, adverse outcomes, and more strain on healthcare resources. 2020-06-11
Urticaria (angioedema) and COVID- 19 infection. The patient was investigated for another differential diagnosis of Urticaria such as parasitic and bacterial infection, for which negative results were found. 2020-06-23
Assessment of Hypokalemia and Clinical Characteristics in Patients With Coronavirus Disease 2019 in Wenzhou, China. Participants included patients who received a diagnosis of COVID-19 according to the criteria issued by the Chinese Health Bureau and were admitted to the hospital. 2020-06-17
COVID-19: A perspective on Africa’s capacity and response. However, there is some cause for optimism, for example, in West Africa where infrastructure like diagnostic testing facilities, intensive care units, surveillance, and systems for reporting emergencies used during the EVD outbreak of 2013-2016 can be leveraged to fight the COVID-19 pandemic. 2020-06-24
High rates of 30-day mortality in patients with cirrhosis and COVID-19. At diagnosis, 64% of patients presented fever, 42% shortness of breath/polypnea, 22% encephalopathy, 96% needed hospitalization or prolonged an ongoing one. […] Serum albumin significantly decreased, while bilirubin, creatinine and prothrombin time significantly increased at COVID-19 diagnosis compared to last available data. […] Seventeen patients died after a median of 10 (4-13) days from COVID-19 diagnosis, with a 30-day-mortality rate of 34%. 2020-06-13
Predictive Value of Sudden Olfactory Loss in the Diagnosis of COVID-19. The aim of this study was to investigate the frequency of olfactory loss in an outpatient population who presented to a coronavirus testing center during a 2-week period and to evaluate the diagnostic value of the symptom “sudden smell loss” for screening procedures. […] In this cross-sectional controlled cohort study, 500 patients who presented with symptoms of a common cold to a corona testing center and fulfilled corona testing criteria completed a standardized diagnostic questionnaire which included the patients’ main symptoms, time course, and an additional self-assessment of the patients’ current smell, taste function, and nasal breathing compared to the level before the onset of symptoms. 2020-06-11
Cerebrovascular events in COVID-19 patients. The diagnosis of cerebrovascular events was confirmed with computed tomography of the brain in most studies reporting neurological events. 2020-06-22
Flight of the COVID-19 patient: experience with a Wuhan evacuee: a case report. This case highlights our patient’s clinical course, including diagnostic work-up, medical management, and challenges in defining non-infectivity in a relatively unknown disease. 2020-06-23
[Nationwide survey on clinical treatment of coronavirus disease 2019 in 9 provinces and municipalities]. Considering that doctors dominated in the diagnosis and treatment of COVID-19, the results of the questionnaires of doctors were mainly analyzed. 2020-06-16
[Clinical characteristics and risk factors of acute kidney injury in coronavirus disease 2019]. According to the diagnostic criteria of Kidney Disease: Improving Global Outcomes (KDIGO), patients with AKI were included in AKI group and those without AKI were included in non-AKI group. 2020-06-16
[Analysis of gastrointestinal symptoms in 80 patients with coronavirus disease 2019]. To investigate the clinical characteristics of gastrointestinal symptoms in patients with coronavirus disease 2019 (COVID-19) during the whole disease process, and provide reference for etiological diagnosis and treatment. 2020-06-16
[Clinical analysis of 23 patients with coronavirus disease 2019 in Xinyang City of Henan Province]. To analyze the epidemiological characteristics and clinical features of the patients with coronavirus disease 2019 (COVID-19), so as to provide basis for clinical diagnosis. […] Epidemic history of contact, fever, pneumonia signs of chest CT, normal or decreased count of leukocyte and lymphopenia are the clinical basis for diagnosis of COVID-19. 2020-06-16
Ultrasound in the management of the critically ill patient with SARS-CoV-2 infection (COVID-19): narrative review. Furthermore, pleural and lung ultrasound can be an alternative diagnostic test to assess the degree of involvement of the lung parenchyma by means of the evaluation of specific ultrasound patterns, identification of pleural effusions and barotrauma. 2020-06-14
The receptor binding domain of the viral spike protein is an immunodominant and highly specific target of antibodies in SARS-CoV-2 patients. There is an urgent need for SARS-CoV-2 serologic tests to identify all infected individuals, irrespective of clinical symptoms, to conduct surveillance and implement strategies to contain spread. […] Our results, which reveal the early kinetics of SARS-CoV-2 antibody responses, support using the RBD antigen in serological diagnostic assays and RBD-specific antibody levels as a correlate of SARS-CoV-2 neutralizing antibodies in people. 2020-06-26
COVID-19 and lessons learned from the pandemic wave of meningococcal meningitis (1985-1990). This joint research project evaluated a rapid antigen test for the diagnosis of acute bacterial meningitis which later proved to be adaptable to the field situation during the 1988 MC epidemic. 2020-06-13
Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infection Mimicking as Pulmonary Tuberculosis in an Inmate. This lack of knowledge leads to diagnostic, therapeutic, and management challenges in such patients. 2020-06-13
Miller Fisher syndrome diagnosis and treatment in a patient with SARS-CoV-2. After neurological examination, including a panel of blood cerebrospinal fluid biomarkers, a diagnosis of Miller Fisher syndrome (MFS) was hypothesized and intravenous immunoglobulin therapy (IVIG) was initiated. 2020-06-15
Mechanisms and evidence of vertical transmission of infections in pregnancy including SARS-CoV-2. Forty studies of COVID-19 pregnancies reviewed suggest a lack of consensus on diagnostic strategy for congenital infection. 2020-06-23
Prevention and control strategies in the diagnosis and treatment of solid tumors in children during the COVID-19 pandemic. Prevention and control of the pandemic and ensuring the progress of the cancer diagnosis and treatment is a significant problem in the current scenario. […] This article proposes a scientific management system for patients with solid tumors to guarantee emergency surgery, rationally arrange limited-term surgery, appropriately defer elective surgery, and guarantee regular chemotherapy, while protecting children from SARS-CoV-2 infection and ensuring the continuity of comprehensive diagnosis and treatment. 2020-06-12
Serological differentiation between COVID-19 and SARS infections. In response to the coronavirus disease 2019 (COVID-19) outbreak, caused by the SARS-CoV-2 virus, multiple diagnostic tests are required globally for acute disease diagnosis, contact tracing, monitoring of asymptomatic infection rates and assessing herd immunity. […] While PCR remains the frontline test of choice in the acute diagnostic setting, serological tests are urgently needed to fulfil the other requirements. 2020-06-12
Retrospective Analysis of 61 Cases of Children Died of Viral Pneumonia. Objective To retrospectively analyze the forensic pathological postmortem examination and clinical data of children who died of viral pneumonia in identification of cause of death cases and to discuss the clinical characteristics and pathological features of viral pneumonia in children, in order to provide reference to pathological diagnosis of viral pneumonia in children caused by 2019 novel coronavirus (2019-nCoV) infection. […] Analyzing the forensic autopsies and the histopathological characteristics could provide reference for pathological diagnosis of viral pneumonia. 2020-06-16
Decoding SARS-CoV-2 Transmission and Evolution and Ramifications for COVID-19 Diagnosis, Vaccine, and Medicine. Tremendous effort has been given to the development of diagnostic tests, preventive vaccines, and therapeutic medicines for coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). […] In particular, we have identified mutations on 40% of nucleotides in the nucleocapsid gene in the population level, signaling potential impacts on the ongoing development of COVID-19 diagnosis, vaccines, and antibody and small-molecular drugs. 2020-06-28
Telemedicine is a useful tool to deliver care to patients with Amyotrophic Lateral Sclerosis during COVID-19 pandemic: results from Southern Italy. We evaluated the feasibility of multidisciplinary assessment of patients with ALS, using telememedicine during the emergency determined by the COVID-19 pandemic. Methods: All patients included in this survey had received a diagnosis of ALS according to international criteria after a complete clinical and paraclinical assessment during 2019. 2020-06-12
Factors Associated With Surgical Mortality and Complications Among Patients With and Without Coronavirus Disease 2019 (COVID-19) in Italy. Diagnosis of COVID-19 was based on positivity of at least 1 of these investigations. 2020-06-12
Clinical outcomes of 402 patients with COVID-2019 from a single center in Wuhan, China. The cohort includes 297 patients with confirmed and 105 with clinical diagnosis. […] The latter group consists of cases with inconclusive nucleic acid test but meeting the criteria for clinical diagnosis. 2020-06-23
Change of the diagnostic distribution in applicants to dermatology after COVID-19 pandemic: What it whispers to us? We aim to evaluate the change in the diagnostic spectrum in dermatology outpatient applications compared to before COVID-19. […] Repeated applications with the same diagnosis in ten days after the first presentation were ignored. […] We think that many factors, such as affecting the quality of life, risk perception, increased stress burden may cause a change in the diagnostic distribution of the dermatology applications. 2020-06-19
Projecting the Course of COVID-19 in Turkey: A Probabilistic Modeling Approach. Our projections showed that if we continued to comply with measures and no drastic changes are seen in diagnosis or management protocols, the epidemic curve would tend to decrease in this time interval. 2020-06-12
Rapid detection of novel coronavirus/Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) by reverse transcription-loop-mediated isothermal amplification. Novel Corona virus/Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2 or 2019-nCoV), and the subsequent disease caused by the virus (coronavirus disease 2019 or COVID-19), is an emerging global health concern that requires a rapid diagnostic test. […] The objective of this study was to develop a rapid screening diagnostic test that could be completed in 30-45 minutes. 2020-06-22
COVID-19 pandemic: Practical considerations on the organization of an allergy clinic - an EAACI/ARIA Position Paper. Based on diagnostic and treatment standards developed by EAACI, on international information regarding COVID-19, on guidelines of the World Health Organization (WHO) and other international organizations as well as on previous experience, a panel of experts including clinicians, psychologists, IT experts and basic scientists along with EAACI and the “Allergic Rhinitis and its Impact on Asthma (ARIA)” inititiative have developed recommendations for the optimal management of allergy clinics during the current COVID-19 pandemic. 2020-06-12
Expression of SARS-CoV-2 Receptor ACE2 and Coincident Host Response Signature Varies by Asthma Inflammatory Phenotype. Over 300 million people carry a diagnosis of asthma with data to suggest they are at higher risk for infection or adverse outcomes from SARS-CoV-2. 2020-06-14
Clinical evaluation of serological IgG antibody response on the Abbott Architect for established SARS-CoV-2 infection. This study aimed to evaluate the diagnostic performance of the Abbott Architect SARS-CoV-2 IgG assay in COVID-19 patients. 2020-06-26
Neutrophil to CD4+ lymphocyte ratio as a potential biomarker in predicting virus negative conversion time in COVID-19. Receiver operating characteristic (ROC) curve analysis and area under the curve (AUC) were used to assess the diagnostic accuracy. 2020-06-26
When to Operate, Hesitate and Reintegrate: Society of Gynecologic Oncology Surgical Considerations during the COVID-19 Pandemic. These challenges have particularly distressing for women with a gynecologic cancer diagnosis and their providers. 2020-06-16
COVID-19 in the radiology department: What radiographers need to know. The aim is to review current literature related to the diagnosis, management, and follow-up of suspected and confirmed Covid-19 cases. […] Medical Imaging plays an important auxiliary role in the diagnosis of Covid-19 patients, mainly those most seriously affected. […] Radiography practice has to significantly adjust to these new requirements to support optimal and safe imaging practices for the diagnosis of Covid-19. 2020-06-25
Toxic shock-like syndrome and COVID-19: A case report of multisystem inflammatory syndrome in children (MIS-C). Many of these cases feature a toxic shock-like syndrome or Kawasaki-like syndrome in the setting of SARS-CoV-2 positive diagnostic testing and the CDC has termed this presentation Multisystem Inflammatory Syndrome (MIS-C). 2020-06-16
Fighting COVID-19: A quick review of diagnoses, therapies, and vaccines. The rapid spread of the virus and the precipitously increasing numbers of cases necessitate the urgent development of accurate diagnostic methods, effective treatments, and vaccines. […] Here, we review the progress of developing diagnostic methods, therapies, and vaccines for SARS-CoV-2 with a focus on current clinical trials and their challenges. […] For diagnosis, nucleic acid amplification tests remain the mainstay diagnostics for laboratory confirmation of SARS-CoV-2 infection, while serological antibody tests are used to aid contact tracing, epidemiological, and vaccine evaluation studies. […] Viral isolation is not recommended for routine diagnostic procedures due to safety concerns. 2020-06-22
Prevalence of hospital PCR-confirmed COVID-19 cases in patients with chronic inflammatory and autoimmune rheumatic diseases. COVID-19 cases in some but not all diagnostic groups had older ages than cases in the reference population. 2020-06-27
Emerging coronaviruses: first SARS, second MERS and third SARS-CoV-2: epidemiological updates of COVID-19. To date, despite the whole world effort to review various aspects of SARS-CoV-2, including epidemiology, clinical manifestations, diagnosis, and treatment options, there are still gaps in the knowledge of this disease and many issues remain unclear. 2020-06-22
COVID 19 diagnostic multiplicity and its role in community surveillance and control. Diagnosis of persons exposed to/infected with severe acute respiratory syndrome-related coronavirus-2 (SARS-CoV-2) is central to controlling the global pandemic of COVID-19. […] Currently, several diagnostic modalities are available for COVID-19, each with its own pros and cons. […] In this paper, we have reviewed the current array of diagnostics for SARS-CoV-2, highlighted the gaps in current diagnostic modalities, and their role in community surveillance and control of the pandemic. […] The different modalities of COVID-19 diagnosis discussed are: clinical and radiological, molecular based (laboratory based and point-of-care), Immunoassay based (ELISA, rapid antigen and antibody detection tests) and digital diagnostics (artificial intelligence based algorithms). 2020-06-22
Comprehensive review of mask utility and challenges during the COVID-19 pandemic. To accommodate limited supplies, techniques for extended use, reuse, and sterilization of masks are strategized. 2020-06-22
MERS-CoV and SARS-CoV infections in animals: a systematic review and meta-analysis of prevalence studies. We performed a systematic literature review with meta-analysis, using three databases to assess MERS-CoV and SARS-CoV infection in animals and its diagnosis by serological and molecular tests. 2020-06-22
Differences among confirmed and not-confirmed COVID-19 patients at “D.Cotugno” hospital, Naples (Italy): what we learned from first suspected cases? In not-confirmed group, Influenza represented the most frequent alternative diagnosis. 2020-06-22
Overview of lethal human coronaviruses. Here, recent studies are summarized and reviewed, with a focus on virus-host interactions, vaccine-based and drug-targeted therapies, and the development of new approaches for clinical diagnosis and treatment. 2020-06-28
Salivary detection of SARS-CoV-2 (COVID-19) and implications for oral health-care providers. The diagnostic and containment efforts for the disease have presented significant challenges for the global health-care community. 2020-06-13
Major cluster of pediatric " true " primary chilblains during the COVID-19 pandemic: a consequence of lifestyle changes due to lockdown. We therefore reached a diagnosis of primary chilblains. 2020-06-13
Value of leukocytosis and elevated C-reactive protein in predicting severe coronavirus 2019 (COVID-19): A systematic review and meta-analysis. Moreover, we aimed to evaluate the diagnostic accuracy of leukocytosis and an elevation of CRP. […] We calculated the diagnostic accuracy of leukocytosis and CRP. 2020-06-27
One-step multiplex TaqMan probe-based method for real-time PCR detection of four canine diarrhea viruses. Thus, fast and accurate diagnostic methods are of great significance for prevention and accurate treatment. […] In this study, we developed a one-step multiplex TaqMan probe-based real-time PCR for the differential diagnosis of four viruses causing canine diarrhea including, CPV (Canine Parvovirus 2), CCoV (Canine Coronavirus), CAstV (Canine Astrovirus), and CaKoV (Canine Kobuviruses). 2020-06-16
Detection of SARS-CoV-2 in Fecal Samples from Patients with Asymptomatic and Mild COVID-19 in Korea. The median interval between COVID-19 diagnosis to the start of fecal sample collection was 37 days (range, 29-41); 213 stool specimens were collected from 46 patients. […] Shedding of virus into feces persisted until day 50 after diagnosis; fecal samples began to test negative before or at approximately the time that respiratory specimens also began to test negative. 2020-06-15
Three novel prevention, diagnostic, and treatment options for COVID-19 urgently necessitating controlled randomized trials. A hypothetical three-part prevention, diagnostic, and treatment approach based on an up-to-date scientific literature review for COVID-19 is proposed. […] Regarding diagnosis, a validated screening questionnaire and digital app for COVID-19 could help identify individuals who are at risk of transmitting the disease, as well as those at highest risk for poor clinical outcomes. […] A three-part prevention, diagnostic, and treatment plan is proposed for addressing the severe complications of COVID-19. 2020-06-16
Severe Acute Respiratory Syndrome Coronavirus -2 (SARS-CoV-2): A global pandemic and treatments strategies. Diagnosis of SARS-CoV-2 is recommended in respiratory secretions by special molecular tests like PCR, chest scan and common laboratory diagnosis. 2020-06-16
CoroNet: A deep neural network for detection and diagnosis of COVID-19 from chest x-ray images. Overall, the proposed model substantially advances the current radiology based methodology and during COVID-19 pandemic, it can be very helpful tool for clinical practitioners and radiologists to aid them in diagnosis, quantification and follow-up of COVID-19 cases. 2020-06-26
Cancer patients affected by COVID-19: Experience from Milan, Lombardy. Considering the first group of six patients, one patient died due to COVID-19 3 days after the diagnosis; while the other patients recovered from COVID-19 after a median of three weeks. 2020-06-14
First detection of SARS-CoV-2 by real-time reverse-transcriptase-polymerase-chain-reaction (RT-PCR) assay in pleural fluid. The gold standard for diagnosis is nucleic acid detection by real-time reverse-transcriptase-polymerase-chain-reaction (RT-PCR) in naso-pharyngeal swabs, but, due to limitations in its sensitivity, thoracic imaging plays a crucial, complementary role in diagnostic work-up and it allows also to reveal atypical findings and potential alternative target for sampling, such as pleural effusion. […] Pleural effusion is not a common finding in COVID-19 infection, but a prompt recognition of this potential localization may be useful to optimize diagnostic work-up as well as management of these patients. 2020-06-28
Laboratory diagnosis of SARS-CoV-2 - A review of current methods. The knowledge of available laboratory methods is essential for early and correct diagnosis of COVID-19 to identify new cases as well as monitoring treatment of confirmed cases. […] In this review we aim to provide the updated information about selection of specimens and availability of various diagnostic methods and their utility with current findings for the laboratory diagnosis of SARS-CoV-2 infection. […] This will guide the healthcare professionals and government organizations to make strategy for establishing diagnostic facilities for SARS-CoV-2 infections. 2020-06-14
Beyond the virus: Ensuring continuity of care for people with diabetes during COVID-19. Ensuring the availability of insulin, other medicines, self-monitoring and diagnostic tools is another challenge. 2020-06-14
Ibuprofen use and clinical outcomes in COVID-19 patients. In a retrospective cohort study of patients with COVID-19 from Shamir Medical Centre, Israel, we monitored any use of ibuprofen from a week before diagnosis of COVID-19 throughout the disease. 2020-06-23
Multiple assays in a real-time RT-PCR SARS-CoV-2 panel can mitigate the risk of loss of sensitivity by new genomic variants during the COVID-19 outbreak. During novel RNA viral outbreaks, detection of the virus relies on real-time reverse transcription polymerase chain reaction (real-time RT-PCR) for detection of the RNA of the virus In the case of SARS-CoV-2, RT-PCR is used for confirmatory diagnosis of symptomatic patients as well as increasingly screening of asymptomatic contacts and subjects at risk. […] The unprecedented outbreak posed the challenge of evaluating the different diagnostic RT-PCR assays sensitivity and specificity without a previous established gold standard.Since the availability of the first SARS-CoV-2 genomic sequence (Wu et al., 2020), several studies have reported a rapid genetic evolution of SARS-CoV-2 through a phylogenetic tree tracking the geographical spread of the virus (Andersen et al., 2020; The Open Science Prize, 2020; Wu et al., 2020; Yi, 2020). […] The impact of non-3 terminal mismatches should not be underestimated, especially in a diagnostic environment (Stadhouders et al., 2010; Whiley and Sloots, 2005). […] CDC 2019-novel coronavirus (2019-nCoV) real-time RT-PCR diagnostic panel. 2020b; Accessed: 09 Apr 2020. […] Molecular diagnosis of a novel coronavirus (2019-nCoV) causing an outbreak of pneumonia. […] Potential preanalytical and analytical vulnerabilities in the laboratory diagnosis of coronavirus disease 2019 (COVID-19). 2020-06-28
Multiplexing primer/probe sets for detection of SARS-CoV-2 by qRT-PCR. The pandemic’s initial challenges include broad diagnostic testing, consistent reagent supply lines, and access to laboratory instruments and equipment. 2020-06-26
Comparison of a laboratory-developed test targeting the envelope gene with three nucleic acid amplification tests for detection of SARS-CoV-2. A diagnostic comparison study was performed by testing nasopharyngeal samples from persons under investigation for coronavirus disease 2019 (COVID-19). 2020-06-26
Clinical and radiological characteristics of pediatric patients with COVID-19: focus on imaging findings. CT imaging has been a detrimental tool in the diagnosis of COVID-19, but it has not been studied thoroughly in pediatric patients and its role in diagnosing COVID-19. 27 pediatric patients with COVID-19 pneumonia were included. 2020-06-17
COVID-19: molecular diagnostics overview. In this article, we provide a molecular overview on the SARS-CoV-2 virus and summarize tremendous efforts that have been made to develop a rapid confirmatory diagnostic test for COVID-19. […] The diagnostic performances of the available tests are analyzed based on the best current information from the early research. 2020-06-17
The lung ultrasound: facts or artifacts? In the era of COVID-19 outbreak. Ultrasound is the most disruptive innovation in intensive care life, above all in this time, with a high diagnostic value when applied appropriately. […] In recent years, point-of-care lung ultrasound has gained significant popularity as a diagnostic tool in the acutely dyspnoeic patients. 2020-06-17
Incorporating Video Visits into Ophthalmology Practice: A Retrospective Analysis and Patient Survey to Assess Initial Experiences and Patient Acceptability at an Academic Eye Center. The most common diagnosis of these visits was postoperative state (20 visits, 9% of the total), followed by conjunctivitis (16 visits, 7%), and keratitis (14 visits, 6%). 2020-06-17
Successful management of the first reported case in Austria of COVID-19 with ARDS. We are discussing some of the clinical challenges and the pitfalls in molecular diagnosis of SARS-CoV-2, including the fact that a positive PCR result may not always reflect infectiousness. 2020-06-17
High mortality in COVID-19 patients with mild respiratory disease. Patients with a diagnosis of interstitial pneumonia caused by SARS-CoV-2, presenting with mild symptoms, and requiring hospitalization in a non-intensive care unit with known discharge status were prospectively collected and retrospectively analyzed. 2020-06-14
A compendium answering 150 questions on COVID-19 and SARS-CoV-2. This paper answers pressing questions, formulated by young clinicians and scientists, on SARS-CoV-2, COVID-19 and allergy, focusing on the following topics: virology, immunology, diagnosis, management of patients with allergic disease and asthma, treatment, clinical trials, drug discovery, vaccine development and epidemiology. 2020-06-14
Pitfalls in SARS-CoV-2 PCR diagnostics. Any deviation of the diagnostic sensitivity and specificity will reduce the predictive values of the test. […] Here, we report the occurrence of contaminations of commercial primers/probe sets with the SARS-CoV-2 target sequence of the RT-qPCR as an example for pitfalls during PCR diagnostics affecting diagnostic specificity. […] Hence, it appears imperative to pre-test each batch of reagents extensively before use in routine diagnosis, to avoid false-positive results and low positive predictive value in low-prevalence situations. […] As such, contaminations may have happened more widely, COVID-19 diagnostic results should be re-assessed retrospectively to validate the epidemiological basis for control measures. 2020-06-14
Ten challenging questions about SARS-CoV-2 and COVID-19. Therefore, further studies, particularly in the context of the virus pathogenesis, diagnosis, treatment, and vaccine development, are warranted. 2020-06-15
Current and emerging diagnostic tests available for the novel COVID-19 global pandemic. Several rapid diagnostic tests have been developed at an astonishing pace; however, COVID-19 requires more highly specific rapid point-of-care diagnostic tests. […] This review describes the currently available testing approaches, as well as the available test assays including the Xpert® Xpress SARS-CoV-2 test (takes ~45 min) and Abbott ID COVID-19 test (5 min) as easy to use point-of-care tests for diagnosis of novel COVID-19 that have so far received the US Food and Drug Administration emergency use authorizations clearance. […] This review is correct as of the date published and will be updated as more diagnostic tests come to light. 2020-06-15
Impact of COVID-19 on thyroid cancer surgery and adjunct therapy. Since papillary carcinoma was the preoperative diagnosis in all cases, radioactive iodine ablation (RIA) therapy was also planned 3-4 weeks following surgery after withdrawing thyroxine and achieving a thyroid stimulating hormone (TSH) level > 30 mU/L. 2020-06-19
Risk Factors for Mortality and Respiratory Support in Elderly Patients Hospitalized with COVID-19 in Korea. CRP > 8.0 mg/dL was strongly associated with MV/HFNC (odds ratio, 26.31; 95% confidence interval, 7.78-88.92; P < 0.001), and showed better diagnostic characteristics compared to commonly used clinical scores. 2020-06-18
Coronavirus and interpersonal violence: A need for digital mental health resources. Through the use of online platforms such as websites, mobile applications, and social media, survivors and perpetrators alike can access tools that help them manage stressors induced by the coronavirus as well as practice emotional regulation techniques and communication strategies at home. 2020-06-15
[Prostate cancer and COVID-19 pandemia: Current recommendations.] According to this classification, the working panel agreed on the distribution of the different diagnostic, therapeutic and follow-up scenarios for PC. […] The risk of severe morbidity as a result of SARS-CoV-2 infection may out weigh the risk of PC morbidity/mortalityin many men; therefore, in the short term it is unlikely that delays in diagnosis or treatment can led to worse cancer outcomes. 2020-06-18
[De-escalation: Testicular cancer.] To provide a priority algorithm for determinate diagnostic, therapeutic and follow-up procedures regarding at testicular cancer, adjusted by institutional requirements. […] The authors support prioritizing diagnostic and therapeutic procedures. […] Initial diagnostic procedures for testicular cancer such as scrotal US, orchiectomy, staging CT and adjuvant treatment (if required) are priority. 2020-06-18
[Benign prostatic hyperplasia management during COVID-19 pandemia.] Clear diagnostic and treatment criteria and referral criteria must be established. […] The diagnosis and prescription of treatment for BPH during the COVID-19 pandemic should be based on telemedicine and joint protocols for primary care attention and urology. 2020-06-18
[Andrology and penile cancer. Recommendations during COVID-19 pandemia.] Most diagnostic and therapeutic procedures in Andrology can be safey postponed during the COVID-19 pandemic. 2020-06-18
[Reconstructive surgery protocol recommendations during COVID-19 pandemia.] Offer some recommendations or guidelines during the evolution of the COVID-19 pandemic in terms of diagnosis, treatment and follow-upin the field of Reconstructive Urology. […] In addition, consensus was reached on recommendations regarding the diagnosis and follow-up of pathology in the field of Reconstructive Urology. […] CONCLUSIONS: Tools should be implemented to facilitate the gathering of the medical visit and diagnostic tests. 2020-06-18
[Functional urology during COVID-19: Recommendations during de-escalation.] MATERIAL AND METHODS: Experts in Functional Urology from different autonomous communities of Spain were contacted to design a strategy to reorganize the activity of both, diagnosis and treatment. 2020-06-18
[Management of neurourological patients during the COVID-19 pandemic.] MATERIALS AND METHODS: Non-systematic review of the literature and national experts’ opinion summarizing the recommendations in the diagnosis, management, and follow-up of neurourological patients during the COVID-19 pandemic. 2020-06-18
[Scholia about the pandemia urbi et orbi et orbe generate by de COVID-19 disease.] The Goddess of Health had two daughters, Panacea and Higinia, the fruit of the first is diagnosis, prognosis and treatment, and the fruit of the second is health management, prevention, and statistics. 2020-06-18
Clinical and radiological features of novel coronavirus pneumonia. Chest CT is highly recommended as the preferred imaging diagnosis method for COVID-19 due to its high density and high spatial resolution. 2020-06-23
COVID 19 and Nepal: Identification of Critical Public Health Measures. The national public health emergency management mechanisms need further strengthening with the proactive engagement of relevant ministries; we need a strong, real-time national surveillance system and capacity building of a critical mass of health care workers; there is a need to further assess infection prevention and control capacity; expand the network of virus diagnostic laboratories in the private sector with adequate surge capacity;implement participatory community engagement interventions and plan for a phased lockdown exit strategy enabling sustainable suppression of transmission at low-level and enabling in resuming some parts of economic and social life. 2020-06-24
[Recommendations for treatment of severe coronavirus disease 2019 based on critical care ultrasound]. Because of its dynamic, real-time, non-invasive, repeatable and other advantages, critical ultrasonography can be widely used in the diagnosis, assessment and guidance of treatment for severe patients. 2020-06-16
Intraoperative Diagnosis of Coronavirus Disease 2019 in an Asymptomatic Patient: A Case Report. Given limited capacities in most health care systems, diagnostic testing is mainly performed in symptomatic patients or those with relevant exposure. […] We report an intraoperative diagnosis of COVID-19 in an asymptomatic patient, prompted by clinical signs. 2020-06-18
COVID-19 Molecular Testing in Korea: Practical Essentials and Answers From Experts Based on Experiences of Emergency Use Authorization Assays. Real-time reverse transcription (RT)-PCR to detect SARS-CoV-2 RNA is currently the most reliable diagnostic method for confirming COVID-19 worldwide. […] Guidelines for clinical laboratories on the COVID-19 diagnosis have been recently published by Korean Society for Laboratory Medicine and the Korea Centers for Disease Control and Prevention. […] Therefore, this guideline is intended as a practical and technical supplement to the “Guidelines for Laboratory Diagnosis of COVID-19 in Korea”. 2020-06-24
Olfactory and Oral Manifestations of COVID-19: Sex-Related Symptoms-A Potential Pathway to Early Diagnosis. Early diagnosis is an essential key to limit the outbreak of the virus. 2020-06-19
Imaging features of the initial chest thin-section CT scans from 110 patients after admission with suspected or confirmed diagnosis of COVID-19. Patients in group 1 (n = 51) presented with symptoms of COVID-19 according to the diagnostic criteria. 2020-06-22
COVID-19 in patients with thoracic malignancies (TERAVOLT): first results of an international, registry-based, cohort study. Eligibility criteria were the presence of any thoracic cancer (non-small-cell lung cancer [NSCLC], small-cell lung cancer, mesothelioma, thymic epithelial tumours, and other pulmonary neuroendocrine neoplasms) and a COVID-19 diagnosis, either laboratory confirmed with RT-PCR, suspected with symptoms and contacts, or radiologically suspected cases with lung imaging features consistent with COVID-19 pneumonia and symptoms. […] Data on demographics, oncological history and comorbidities, COVID-19 diagnosis, and course of illness and clinical outcomes were collected. […] Between March 26 and April 12, 2020, 200 patients with COVID-19 and thoracic cancers from eight countries were identified and included in the TERAVOLT registry; median age was 68·0 years (61·8-75·0) and the majority had an Eastern Cooperative Oncology Group performance status of 0-1 (142 [72%] of 196 patients), were current or former smokers (159 [81%] of 196), had non-small-cell lung cancer (151 [76%] of 200), and were on therapy at the time of COVID-19 diagnosis (147 [74%] of 199), with 112 (57%) of 197 on first-line treatment. 152 (76%) patients were hospitalised and 66 (33%) died. 13 (10%) of 134 patients who met criteria for ICU admission were admitted to ICU; the remaining 121 were hospitalised, but were not admitted to ICU. 2020-06-19
SARS-CoV-2 shedding and seroconversion among passengers quarantined after disembarking a cruise ship: a case series. A combination of RT-PCR and serology should be implemented for case finding and contact tracing to facilitate early diagnosis, prompt isolation, and treatment. 2020-06-19
Review of practical recommendations for otolaryngologists and head and neck surgeons during the COVID-19 pandemic. It summarizes data concerning COVID-19 transmission, diagnosis, and clinical presentation highlighting the information significant for otolaryngologists. 2020-06-19
Recommendations on diagnosis and treatment in hepatobiliary surgery under 2019-nCoV epidemic. It is hoped that through this article, surgeons will have a better system in hepatobiliary diseases classification, treatment selection, and protective measures to improve the clinical practice in accordance with the guidelines for the diagnosis and treatment of the novel coronavirus pneumonia. 2020-06-19
Re-evaluation of retested nucleic acid-positive cases in recovered COVID-19 patients: Report from a designated transfer hospital in Chongqing, China. Previous studies have paid more attention to the epidemic situation of COVID-19 and patient diagnosis and treatment. 2020-06-19
Management of Female and Functional Urology Patients During the COVID Pandemic. To propose, based on expert advice and current evidence where available, a strategy to reorganize female and functional urological (FFU) activity (diagnosis and treatment). 2020-06-19
Meta-analysis investigating the relationship between clinical features, outcomes, and severity of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pneumonia. Investigation of clinical characteristics and outcomes of severe cases of COVID-19 will contribute to early prediction, accurate diagnosis, and treatment to improve the prognosis of patients with severe illness. 2020-06-19
Upper and Lower Airways Functional Examination in Asthma and Respiratory Allergic Deseases. Considerations in the SARS-CoV-2 Post-Pandemic Situation. Airway examination techniques are procedures that can potentially transmit infectious diseases to both patients and healthcare professionals who perform them, by various mechanisms. […] Being already in the early stages after the peak of the pandemic, we still do not know for sure what its consequences will be in the short or long term, since there are important gaps in the knowledge of aspects as fundamental as the transmission mechanisms of the virus, its pathophysiology and immune response or its diagnosis. […] In this review we will examine the different examination techniques available on the assessment of patients suffering from respiratory allergy, asthma and associated diseases, int the postpandemic momentum, highlighting their possible advantages and disadvantages. […] And at the same time we will approach the analysis of the intrinsic value that these interventions provide from the point of view of both diagnosis and management of these patients. 2020-06-16
Guillain-Barré syndrome following COVID-19: a newly emerging post-infectious complication. Increasing appreciation of this by clinicians will ensure earlier diagnosis, monitoring and treatment of patients presenting with this. 2020-06-23
Outcomes after Tracheostomy in COVID-19 Patients. Both open surgical and percutaneous dilational tracheostomy techniques were performed utilizing methods to mitigate aerosols. 2020-06-16
Saliva as a Potential Diagnostic Specimen for COVID-19 Testing. This article explores the current literature and suggests saliva as an emerging potential diagnostic specimen for COVID-19 testing. 2020-06-16
Facial Plastic and Reconstructive Surgery During the COVID-19 Pandemic: Implications in Craniomaxillofacial Trauma and Head and Neck Reconstruction. Surgeons operating in the head and neck are particularly at risk of occupational COVID-19 exposure during diagnostic and therapeutic procedures and must therefore be cognizant of protocols in place to mitigate exposure risk and optimize patient care. 2020-06-16
[Infection prevention and control of bedside blood purification treatment in patients with COVID-19]. Bedside blood purification treatment in the COVID-19 isolation ward, the occurrence and spread of healthcare associated infection can be effectively controlled through effective infection prevention and control management, including divisional isolation, patient behavior isolation and patient placement, operator personal protection and hand hygiene, dialysis waste fluid disposal, isolation room’s air purification, object surfaces, medical devices and medical fabrics disinfection, which can provide experience for diagnosis, treatment and prevention and control of patients in the respiratory infectious disease ward. 2020-06-17
Incidental typical COVID-19 appearance on the lung bases, visualized at abdominal CT for a patient that presented with abdominal pain and nausea. The diagnosis of COVID-19 was confirmed afterward by laboratory testing. 2020-06-17
Coronavirus Disease and New-Onset Atrial Fibrillation: Two Cases. The first patient presented with symptomatic atrial fibrillation; however, during his hospitalization course, he developed a fever, which led to the diagnosis of infection with SARS-CoV-2. 2020-06-17
Extrapulmonary Gastrointestinal Presentation of Coronavirus (COVID-19): A Case Report and Review of Literature. Given the patient’s lack of respiratory symptoms, diagnosis and treatment were ultimately delayed. 2020-06-17
The application of DNA nucleotide footprint plotting in coronavirus. The current project provides a novel tool for biological studies that can contribute to breakthroughs in coronavirus diagnosis, treatment, and prevention. 2020-06-17
Potential dual dengue and SARS-CoV-2 infection in Thailand: A case study. We describe a Thai patient with an initial diagnosis of dengue fever who was later confirmed to also infect with SARSCoV-2. 2020-06-17
Rapid Detection of IgM Antibodies against the SARS-CoV-2 Virus via Colloidal Gold Nanoparticle-Based Lateral-Flow Assay. Meanwhile, detecting specific antibodies in blood, such as the IgM antibody, against the SARS-CoV-2 virus is another choice for COVID-19 diagnosis, as it is widely accepted that IgM is an important indicator in the acute infection period. […] In this study, a colloidal gold nanoparticle-based lateral-flow (AuNP-LF) assay was developed to achieve rapid diagnosis and on-site detection of the IgM antibody against the SARS-CoV-2 virus through the indirect immunochromatography method. […] As a whole, in the light of its advantages such as excellent specificity and stability, easy operation, low cost, and being less time-consuming, AuNP-LF assay is a feasible method for the diagnosis of COVID-19 in primary hospitals and laboratories, especially in emergency situations in which numerous samples need to be tested on time. 2020-06-17
Acute smell and taste loss in outpatients: all infected with SARS-CoV-2? The aim of our study was to compare the characteristics of loss of smell and taste between patients with a clinical diagnosis of SARS-CoV-2 infection to patients with a RT-PCR diagnosis. 2020-06-16
Use of Telemedicine and Virtual Care for Remote Treatment in Response to COVID-19 Pandemic. Thus, concerns about the reducing and management of COVID-19 are on the rise, as there is need to provide diagnosis, treatment, monitoring, and follow-ups during the pandemic. 2020-06-23
[COVID-19 Concerns and Worries in Patients with Mental Illness]. Psychiatric and psychotherapeutic care needs to be adapted accordingly; the specific burden and distress needs to be examined actively in patients from all diagnostic groups. 2020-06-16
[Dynamic Changes of CT Findings in Pneumonia Patients with Coronavirus Disease 19]. The chest CT findings of the pneumonia patients with coronavirus disease 19 (COVID-19) were summarized to provide an auxiliary diagnostic basis for the early detection of infected patients. […] As an important diagnostic examination method for COVID-19, CT is conducive to the rapid diagnosis of the disease in patients with epidemiological history. 2020-06-17
Ischemic stroke associated with novel coronavirus 2019: a report of three cases. Therefore, regarding the current situation of the COVID-19 pandemic, it is indispensable that the possible diagnosis of COVID-19 vasculopathy is considered in all ischemic strokes of unclear etiology. 2020-06-25
Comparison and Application of Different Immunoassay Methods for the Detection of SARS-CoV-2. A reasonable understanding of the performance of reagents with different methodologies can help in clinical disease diagnosis effectively and assist in the diagnosis of the progression of COVID-19, for which the dynamic changes of antibody will provide reliable evidence. 2020-06-16
COVID-19 in the Cancer Patient. Important perioperative management recommendations during this outbreak are emphasized, in addition to discussion of current treatment techniques and strategies available in the battle against COVID-19. 2020-06-25
Urological implications of SARS CoV-19. The authors provide scientific basis to urologists to help identify patients by remote consultation who are likely to be harmed by coming to the hospital, and not to miss those who need hospitalization for diagnostic or therapeutic interventions. 2020-06-22
Seroepidemiologic Study Designs for Determining SARS-COV-2 Transmission and Immunity. Successful deployment of serologic studies depends on type and performance of serologic tests, population studied, use of adequate study designs, and appropriate analysis and interpretation of data. 2020-06-16
Clinical and epidemiological characteristics of pediatric SARS-CoV-2 infections in China: A multicenter case series. We describe the clinical and epidemiological characteristics of pediatric patients to provide valuable insight into the early diagnosis and assessment of COVID-19 in children. 2020-06-25
Regional outcomes of severe acute respiratory syndrome coronavirus 2 infection in hospitalised patients with haematological malignancy. Immunosuppressive or cytotoxic treatment within 3 months of the diagnosis of SARS-CoV-2 infection was associated with a significantly higher preliminary Case Fatality Rate (pCFR) of 70%, compared with 28% in those not on active treatment (P = 0.0013, 2 proportions z-test). 2020-06-16
Potent neutralization of SARS-CoV-2 by human antibody heavy-chain variable domains isolated from a large library with a new stable scaffold. These VH domains may have potential applications for prophylaxis and therapy of COVID-19 alone or in combination, as well as for diagnosis and as tools for research. 2020-06-26
Group Testing-Based Robust Algorithm for Diagnosis of COVID-19. In this paper, we consider a diagnosis method for COVID-19, which is characterized by a very rapid rate of infection and is widespread. […] A possible method for avoiding severe infections is to stop the spread of the infection in advance by the prompt and accurate diagnosis of COVID-19. 2020-06-17
The Evolution of Care of Cancers of the Head and Neck Region: State of the Science in 2020. This review explores advances in diagnostic criteria, prognostic factors, and management for subsites including head and neck squamous cell carcinoma and the various forms of skin cancer (basal cell carcinoma, cutaneous squamous cell carcinoma, Merkel cell carcinoma, and melanoma). 2020-06-19
Nutritional Support in Coronavirus 2019 Disease. The epidemic that broke out in Chinese Wuhan at the beginning of 2020 presented how important the rapid diagnosis of malnutrition (elevating during intensive care unit stay) and the immediate implementation of caloric and protein-balanced nutrition care are. […] The Chinese have published their recommendations including principles for the diagnosis of nutritional status along with the optimal method for nutrition supply including guidelines when to introduce education approach, oral nutritional supplement, tube feeding, and parenteral nutrition. 2020-06-24
Phase 2 and Later of COVID-19 Lockdown: Is it Possible to Perform Remote Diagnosis and Intervention for Autism Spectrum Disorder? An Online-Mediated Approach. The centers and institutions that deal with the diagnosis and intervention of children with autism spectrum disorder (ASD) require rapid functional adaptation to respond to patients’ needs. […] The possibility of using technology to activate and manage diagnostic (preliminary diagnosis) and intervention processes should be explored. […] Two developed telemedicine working models for diagnosis and intervention, including synchronous and asynchronous transmissions, are presented. […] The diagnosis step is composed by two different and consecutives phases: (A) pre-specialistic consultation (PSC) and (B) specialistic assessment. 2020-06-17
The broad-spectrum antiviral recommendations for drug discovery against COVID-19. Moreover, the present review investigates the epidemiology, diagnosis, structure, and replication of COVID-19 for better understanding. 2020-06-25
Diagnostic utility of additional whole-chest CT as part of an acute abdominal pain CT imaging pathway during the COVID-19 pandemic. To evaluate the diagnostic utility of additional whole-chest computed tomography (CT) in identifying otherwise unheralded COVID-19 lung disease as part of an acute abdominal pain CT imaging pathway in response to the COVID-19 pandemic. […] Whole-chest CT as part of an acute abdominal pain CT imaging pathway has a very low diagnostic yield for our cohort of patients. 2020-06-19
Does the maternal-fetal transmission of SARS-CoV-2 occur during pregnancy? Using the Real-time Polymerase Chain Reaction techniques for SARS-CoV-2 nucleic acids, the possible presence of this germ in vaginal discharge and amniotic fluid was investigated in four pregnant Caucasian patients affected by mild acute symptoms of COVID-19 during the second trimester of pregnancy. 2020-06-19
Clinical and Demographic Characteristics of Cluster Cases and Sporadic Cases of Coronavirus Disease 2019 (COVID-19) in 141 Patients in the Main District of Chongqing, China, Between January and February 2020. MATERIAL AND METHODS A retrospective study included 141 patients with a diagnosis of COVID-19. […] The diagnosis was confirmed using real-time reverse transcription-polymerase chain reaction (RT-PCR) for SARS-CoV-2. 2020-06-23
Optimization of primer sets and detection protocols for SARS-CoV-2 of coronavirus disease 2019 (COVID-19) using PCR and real-time PCR. Various SARS-CoV-2 diagnostic kits are already available from many companies and national health agencies. […] However, publicly available information on these diagnostic kits is lacking. […] During the development of the detection protocol, we found that unoptimized primer sets could inadvertently show false-positive results, raising the possibility that commercially available diagnostic kits might also contain primer sets that produce false-positive results. 2020-06-19
Influence of COVID-19 on Cerebrovascular Disease and its Possible Mechanism. With the rise of COVID-19 in China and worldwide, further prevention, diagnosis, and treatment measures are a critical unmet need. […] This paper summarizes the influence of COVID-19 on cerebrovascular disease and discusses possible pathophysiological mechanisms to provide new angles for the prevention and diagnosis of this disease. 2020-06-19
Effect of COVID-19 Epidemic on Delay of Diagnosis and Treatment Path for Patients with Nasopharyngeal Carcinoma. To prevent further spread of the disease, restrictions of population flow from the government and measures to reduce virus transmission from hospitals may lead to the delay of diagnosis and treatment in patients with nasopharyngeal carcinoma (NPC). […] The waiting intervals of each step and variation from the diagnosis and treatment path of NPC between two groups were compared. […] The prevalence of COVID-19 caused delay in the diagnosis and treatment of NPC patients to a certain extent. […] More specific measures should be taken to balance the risk of delayed diagnosis and treatment of NPC and infection of COVID-19. 2020-06-19
Characteristics of in peripheral blood of 70 hospitalized patients and 8 diarrhea patients with COVID-19. Although there is no statistical difference in GGT, 100% of the 7 patients tested decreased. Conclusion: Our data recommended that the ESR, CRP, PT, IL6, lymphocyte count, GGT, prealbumin and CD4 have important value in the diagnosis of COVID-19, and the decrease of GGT may be an important indicator for judging the intestinal dysfunction of patients. 2020-06-22
Ultraviolet irradiation doses for coronavirus inactivation - review and analysis of coronavirus photoinactivation studies. Background: To slow the increasing global spread of the SARS-CoV-2 virus, appropriate disinfection techniques are required. 2020-06-19
Clinical characteristics, diagnosis, and treatment of COVID-19: A case report. What is the clinical diagnosis and how should such patients be treated? […] As a clinician, mastery of the clinical characteristics, basic diagnosis, and treatment methods of COVID-19 are required to provide help to patients. […] We report a typical case of COVID-19, analyze its clinical characteristics, summarize its clinical diagnosis and treatment experience, and provide a reference for clinical colleagues. 2020-06-19
Preventive and Control Measures for the Coronavirus Pandemic in Clinical Dentistry. Nosocomial infection prevention and control concepts and measures relating to dental diagnosis and treatment are critically checked in the hospital. 2020-06-18
Prevalence of COVID-19 Infection and Outcomes Among Symptomatic Healthcare Workers in Seattle, Washington. Among 174 positive employees reached for follow-up at least 14 days after diagnosis, 6 reported COVID-related hospitalization; all recovered. 2020-06-17
Performance of oropharyngeal swab testing compared to nasopharyngeal swab testing for diagnosis of COVID-19 -United States, January-February 2020. Among 146 nasopharyngeal (NP) and oropharyngeal (OP) swab pairs collected ≤7 days since illness onset, CDC real-time RT-PCR SARS-CoV-2 assay diagnostic results were 95.2% concordant. 2020-06-17
Negative nasopharyngeal swabs early in the course of COVID-19. The diagnosis of COVID-19 is made by detection of SARS-CoV-2 RNA by reverse transcription polymerase chain reaction (RT-PCR). 2020-06-25
Bladder Cancer at the time of COVID-19 Outbreak. We aim to summarise updates on diagnosis, treatment and follow up of bladder cancer during the COVID-19 outbreaks. 2020-06-17
Laparoscopic and Robotic Urology Surgery during Global Pandemic COVID19. Known laparoscopic and robotic assisted approaches and techniques for the surgical management of urological malignant and benign diseases are commonly used around the World. […] A concern with the use of minimally invasive techniques arose due to a proposed risk of viral transmission of the coronavirus disease with the creation of pneumoperitoneum. 2020-06-17
Summary and considerations in genitourinary cancer patient care during the COVID-19 Pandemic. A non-systematic review of available literature on the management of urological malignancies during the COVID-19 pandemic was performed to summarize recommendations to improve the diagnosis and treatment of urological cancers during and after the contingence, including clinical and research aspects. […] Urological cancer diagnosis and management should be tailored according to the severity of the COVID-19 crisis in each region and the aggressiveness of each tumor. 2020-06-17
Cancer and SARS-CoV-2 Infection: Diagnostic and Therapeutic Challenges. Finally, we have highlighted some diagnostic challenges in the recognition of SARS-CoV-2 infection in cancer-infected patients. 2020-06-18
Effectiveness of Computed Tomography in the Diagnosis of Novel Coronavirus-2019. Given the scarcity of resources including healthcare staff, hospital capacities, test kits, etc., timely diagnosis and treatment of this virus are of paramount importance. […] Because the spreading rate of the virus is very high worldwide and there is no definitive treatment, diagnosis becomes even more important. […] The objective of this review is to evaluate the use of chest computed tomography, one of the commonly used radiologic imaging modalities, in the diagnosis of COVID-19 in light with the current literatüre. 2020-06-19
Pathological Findings and Management of COVID-19 Patients: A Brief Overview of Modern-day Pandemic. Real-time polymerase chain reaction (PCR; rt-PCR) is the gold standard diagnostic test, and chest X-ray and computed tomography (CT) scan are the other main investigations. 2020-06-19
Pitfalls of Computed Tomography in the Coronavirus 2019 (COVID-19) Era: A New Perspective on Ground-Glass Opacities. We studied the different pathologies underlying GGO features: neoplastic diseases and non-neoplastic diseases (viral pneumonias, interstitial pneumonias, and cardiopulmonary diseases) in order to avoid pitfalls and to reach the correct diagnosis. […] Conclusions GGO remains a diagnostic challenge. […] Although CT represents a fundamental diagnostic tool because of its sensitivity, it still needs to be integrated with clinical data to achieve the best clinical management. 2020-06-19
Review of chest CT manifestations of COVID-19 infection. The diagnosis is based on RT-PCR test through a nasopharyngeal swab. […] Here, we review the pertinent clinical findings and the current published data describing chest CT findings in COVID-19 pneumonia, the diagnostic performance of CT for diagnosis, including differential diagnosis, as well the evolving role of imaging in this disease. 2020-06-19
Management of COVID-19-Positive Pediatric Patients Undergoing Minimally Invasive Surgical Procedures: Systematic Review and Recommendations of the Board of European Society of Pediatric Endoscopic Surgeons. A consensus regarding urgent laparoscopic procedures, setting and operation techniques was obtained within the Committee and the Board. Conclusions: The ESPES proposes the following recommendations in case minimally invasive surgery is needed in a COVID-19 positive pediatric patients: (1) consider conservative treatment whenever safely possible, (2) dedicate a theater, columns and reusable laparoscopic instrumentation to COVID-19 pediatric patients, (3) prefer disposable instrumentation and cables, (4) use low CO2 insufflation pressures, (5) use low power electrocautery, (6) prefer closed-systems CO2 insufflation and desufflation systems, and (7) avoid leaks through ports. 2020-06-23
Social media influence in the COVID-19 Pandemic. Responsible use of these tools can help quickly disseminate important new information, relevant new scientific findings, share diagnostic, treatment, and follow-up protocols, as well as compare different approaches globally, removing geographic boundaries for the first time in history. 2020-06-18
COVID-19 and Older Adults. Lessons Learned from the Italian Epicenter. It is suggested that stratification by frailty level may help to detect the most vulnerable, and decisions about healthcare resource prioritization should not be taken based only on age itself or previous diagnosis, such as having dementia. 2020-06-20
Challenges amid COVID-19 times - Review of the changing practices in a clinical chemistry laboratory from a developing country. It highlights the challenges faced and the appropriate responses to ensure the provision of diagnostic facilities during the COVID-19 outbreak. 2020-06-20
COVID-19: Taiwan’s epidemiological characteristics and public and hospital responses. By the end of February 2020 in Taiwan, 2,150 patients received diagnostic COVID-19 testing and 39 confirmed cases were detected. 2020-06-20
Subtotal laparoscopic cholecystectomy for gangrenous gallbladder during recovery from COVID-19 pneumonia. Early diagnosis and surgical therapy are critical in patients with gangrenous cholecystitis. 2020-06-20
Protection for Otolaryngologic Surgery in the COVID-19 Pandemic. Surgical procedures must be categorized according to aerosolization risk and the possibility of COVID-19 diagnosis, according to use of personal protective equipment. 2020-06-20
Management of an Organ Donation Process in COVID-19 Pandemic: First Case of Turkey. The main steps for diagnosis of COVID-19 are investigation of symptoms, recollection of travel and physical contact history, and testing using the real time polymerase chain reaction (RT-PCR) test. 2020-06-20
Discovery of Aptamers Targeting Receptor-Binding Domain of the SARS-CoV-2 Spike Glycoprotein. These aptamers present an opportunity for generating new probes for recognition of SARS-CoV-2, and could provide assistance in the diagnosis and treatment of SARS-CoV-2 while providing a new tool for in-depth study of the mechanisms behind the coronavirus infection. 2020-06-19
Coronavirus disease 2019: A new severe acute respiratory syndrome from Wuhan in China. The purpose of this article is to overview the history, epidemiology, clinical characteristics, diagnosis, and treatment of COVID 2019 reported in recently published studies. 2020-06-23
Rapid Validation of Telepathology by an Academic Neuropathology Practice During the COVID-19 Pandemic. To conduct a rapid validation study assessing our ability to reliably provide diagnostic Neuropathology services via a whole slide imaging (WSI) platform as part of our departmental COVID-19 planning response. […] This retrospective study assessed diagnostic concordance of neuropathological diagnoses rendered via WSI as compared to those originally established via traditional histopathology in a cohort of 30 cases encompassing a broad range of neurosurgical and neuromuscular entities. […] There were no major or minor diagnostic discrepancies identified in either the attending neuropathologist or neuropathology trainee groups for either the neurosurgical or neuromuscular case cohorts. […] This study provides a framework for rapid subspecialty validation and deployment of WSI for diagnostic purposes during a pandemic event. 2020-06-19
Feasibility, Utility, and Limitations of a Rapid Community Behavioral Diagnosis for Social Distancing During the 2020 Coronavirus Pandemic. To evaluate the feasibility, utility, and limitations of a rapid community behavioral diagnosis (RCBD) for social distancing behaviors to prevent coronavirus transmission during a global coronavirus pandemic. 2020-06-19
Atypical and novel presentations of Coronavirus Disease 2019: a case series of three children. Typical presentations of Coronavirus Disease 2019 (COVID19) including respiratory symptoms (cough, respiratory distress and hypoxia), fever and dyspnea are considered main symptoms in adults, but atypical presentation children could be a diagnostic challenge We report three children whose initial presentation was gastrointestinal, and in whom COVID-19 infection was found, concluding that cases of acute appendicitis, mesenteric adenitis and flank tenderness may mask and infection with this virus, which should therefore be investigated. 2020-06-19
Identification of a novel dual-target scaffold for 3CLpro and RdRp proteins of SARS-CoV-2 using 3D-similarity search, molecular docking, molecular dynamics and ADMET evaluation. The crystallographic structures of 3CLpro (PDB: 6LU7) and RdRp (PDB 6ML7) were used in virtual screening of 50000 chemical compounds obtained from the CAS Antiviral COVID19 database using 3D-similarity search and standard molecular docking followed by ranking and selection of compounds based on their binding affinity, computational techniques for the sake of details on the binding interactions, absorption, distribution, metabolism, excretion, and toxicity prediction; we report three 4-(morpholin-4-yl)-1,3,5-triazin-2-amine derivatives; two compounds (2001083-68-5 and 2001083-69-6) with optimal binding features to the active site of the main protease and one compound (833463-19-7) with optimal binding features to the active site of the polymerase for further consideration to fight COVID-19. 2020-06-25
Facts and myths: Efficacies of repurposing chloroquine and hydroxychloroquine for the treatment of COVID-19. The international health authorities have focused on rapid diagnosis and isolation of patients as well as search for therapies able to counter the disease severity. 2020-06-19
Estimating the daily trend in the size of the COVID-19 infected population in Wuhan. Clinical diagnosis could be a good complement to the method of confirmation at that time. 2020-06-28
Emergence of Undetectable Malaria Parasites: A Threat under the Radar amid the COVID-19 Pandemic? Rapid diagnostic tests (RDTs) play a critical role in malaria diagnosis and control. 2020-06-19
Meta-analysis of diagnostic performance of serological tests for SARS-CoV-2 antibodies up to 25 April 2020 and public health implications. We reviewed the diagnostic accuracy of SARS-CoV-2 serological tests. 2020-06-26
Severe Acute Respiratory Syndrome Coronavirus 2 among Asymptomatic Workers Screened for Work Resumption, China. Among 6 contacts who had serologic tests, none were positive. 2020-06-19
COVID-19 and tuberculosis: A mathematical model based forecasting in Delhi, India. The TB treatment centres and hospitals needs to be prepared for early diagnosis and management of severe COVID-19 in TB patients. 2020-06-22
Ultra-sensitive and high-throughput CRISPR-p owered COVID-19 diagnosis. This situation highlights the need for rapid, sensitive SARS-CoV-2 diagnostic assays capable of high-throughput operation that can preferably utilize existing equipment to facilitate broad, large-scale screening efforts. […] CRISPR assay diagnostic results obtained nasal swab samples of individuals with suspected COVID-19 cases were comparable to paired results from a CDC-approved quantitative RT-PCR (RT-qPCR) assay performed in a state testing lab, and superior to those produced by same assay in a clinical lab, where the RT-qPCR assay exhibited multiple invalid or inconclusive results. […] Our assay also demonstrated greater analytical sensitivity and more robust diagnostic performance than other recently reported CRISPR-based assays. 2020-06-25
Forecasting the Future of Urology Practice: A Comprehensive Review of the Recommendations by International and European Associations on Priority Procedures During the COVID-19 Pandemic. Each UAS official website was searched between April 8 and 18, 2020, to retrieve any document, publication, or position paper on prioritization strategies regarding both diagnostic and therapeutic urological procedures, and any recommendations on the use of telemedicine and minimally invasive surgery. 2020-06-22
Quality Improvement Tool to Rapidly Identify Risk Factors for SARS-CoV-2 Infection among Healthcare Workers. These methods, along with data management and analytic techniques, can be widely useful and shared globally. 2020-06-22
COVID-19 in pregnancy was associated with maternal morbidity and preterm birth. This retrospective single-center study includes all consecutive pregnant women with confirmed (laboratory-confirmed) or suspected (according to version 7.0 of the Chinese management guideline) COVID-19 infection, regardless of gestational age at diagnosis, admitted to the Strasbourg University Hospital (France) from March 1 to April 3, 2020. 2020-06-21
Combination of serological total antibody and RT-PCR test for detection of SARS-COV-2 infections. The results indicated that diagnostic sensitivity and specificity were 95.7 % and 98.7 %, 92.2 % and 100 % by total antibody tests and RT-PCR, respectively. […] This study supported the advantage of the combined method for detection of SARS-COV-2 with a high degree of sensitivity and specificity, as a useful tool for accurate diagnosis and timely treatment of suspected patients, epidemiological investigation, as well as monitoring ongoing outbreaks of infections with SARS-COV-2. 2020-06-23
Prevalence and characterization of asthma in hospitalized and non-hospitalized patients with COVID-19. Medical records of patients with COVID-19 were searched by a computer algorithm (March 1-April 15, 2020), and chart review was used to validate the diagnosis of asthma and medications prescribed for asthma. 2020-06-21
Potential COVID-19 infection in patients with severe multiple sclerosis treated with alemtuzumab. Ten patients with a diagnosis of relapsing-remitting MS were phoned and asked about symptoms suggestive and COVID-19 using a semi-structured questionnaire. […] The mean time since disease diagnosis was 17.30 ± 8.59 years, and all were patients with relapsing-remitting MS. 2020-06-26
Smell and taste dysfunctions in COVID-19 are associated with younger age in ambulatory settings - a multicenter cross-sectional study. STD onset time, recovery rate, time to recovery, hospital admission, pneumonia diagnosis, comorbidities, smoking and symptoms were analyzed. 2020-06-19
Immune-related (IR)-pneumonitis during the COVID-19 pandemic: multidisciplinary recommendations for diagnosis and management. Expert guidelines for the diagnosis and management of IR-pneumonitis include multidisciplinary input from medical oncology, pulmonary medicine, infectious disease, and radiology specialists. […] Symptoms and imaging findings from IR-pneumonitis and COVID-19 pneumonia can be similar, and early COVID-19 viral testing may yield false negative results, complicating the diagnosis and management of both entities. […] Herein, we present a set of multidisciplinary consensus recommendations for the diagnosis and management of IR-pneumonitis in the setting of COVID-19 including: (1) isolation procedures, (2) recommended imaging and interpretation, (3) adaptations to invasive testing, (4) adaptations to the management of IR-pneumonitis, (5) immunosuppression for steroid-refractory IR-pneumonitis, and (6) management of suspected concurrent IR-pneumonitis and COVID-19 infection. 2020-06-27
The Limited Sensitivity of Chest Computed Tomography Relative to Reverse Transcription Polymerase Chain Reaction for Severe Acute Respiratory Syndrome Coronavirus-2 Infection: A Systematic Review on COVID-19 Diagnostics. Several studies suggest the sensitivity of chest computed tomography (CT) is far greater than that of reverse transcription polymerase chain reaction (RT-PCR) in diagnosing COVID-19 patients, and therefore, CT should be included as a primary diagnostic tool. 2020-06-26
Overview of therapeutic drug research for COVID-19 in China. In response to this epidemic, China has issued seven trial versions of diagnosis and treatment protocol for COVID-19. 2020-06-28
[Antithrombotic treatments in patients with SARS-CoV-2 infection: from current evidence to reasonable recommendations - A position paper from the Italian Working Group on Atherosclerosis, Thrombosis and Vascular Biology]. In the present position paper we collected current evidence from the literature to provide practical recommendations on the management of antithrombotic therapies (antiplatelet and anticoagulant) in various clinical contexts prevalent during the SARS-CoV-2 outbreak: in-home management of oral anticoagulant therapy; interactions between drugs used in the SARS-CoV-2 infection and antithrombotic agents; in-hospital management of antithrombotic therapies; diagnosis, risk stratification and treatment of in-hospital thrombotic complications. 2020-06-19
[Late occurrence of pulmonary embolsim in SARS-CoV-2 pneumonia: a case series]. Case 2: a 76-year-old man with a diagnosis of SARS-CoV-2 pneumonia followed by pulmonary embolism 20 days later, high-resolution computed tomography on that time showed a partial resolution of crazy paving consolidation. […] These findings suggest a role for medium-long term therapeutic anticoagulation started at the time of SARS-CoV-2 pneumonia diagnosis. 2020-06-19
Prevalence of Taste and Smell Dysfunction in Coronavirus Disease 2019. Early diagnosis of coronavirus disease 2019 (COVID-19) may help control the diffusion of the disease into the population. […] To investigate the presence of sinonasal manifestations at the onset of COVID-19 to achieve an earlier diagnosis. […] Sinonasal manifestations reported before COVID-19 diagnosis were studied with a validated questionnaire: Italian Sino-Nasal Outcome Test 22 (I-SNOT-22). […] The prevalence of sinonasal manifestations preceding COVID-19 diagnosis. […] The general practitioner may play a pivotal role in identifying potential COVID-19 in patients at an early stage if taste and/or smell alterations manifest and in suggesting quarantine before confirmation or exclusion of the diagnosis. 2020-06-23
Diabetic Ketoacidosis in COVID-19: unique concerns and considerations. Topics addressed include diagnosis, triage, and the fundamental principles of treatment with a focus on the importance of characterizing DKA severity and medical complexity to determine the best approach. 2020-06-19
Infectious Diseases Society of America Guidelines on the Diagnosis of COVID-19. Accurate molecular diagnostic tests are necessary for confirming a diagnosis of coronavirus disease 2019 (COVID-19). […] The numbers of available SARS-CoV-2 nucleic acid detection tests are rapidly increasing, as is the COVID-19 diagnostic literature. […] The IDSA’s goal was to develop an evidence-based diagnostic guideline to assists clinicians, clinical laboratorians, patients and policymakers in decisions related to the optimal use of SARS-CoV-2 nucleic acid amplification tests. […] In addition, we provide a conceptual framework for understanding molecular diagnostic test performance, discuss the nuance of test result interpretation in a variety of practice settings, and highlight important unmet research needs in the COVID-19 diagnostic testing space. […] The panel agreed on 15 diagnostic recommendations. […] Recognizing these limitations, the IDSA panel weighed available diagnostic evidence and recommends nucleic acid testing for all symptomatic individuals suspected of having COVID-19. 2020-06-19
Recommendations for Hospital-Based Physical Therapists Managing Patients With COVID-19. Respiratory support includes breathing control, thoracic expansion exercises, airway clearance techniques, and respiratory muscle strength training. 2020-06-19
Ventilation/perfusion SPECT/CT findings in different lung lesions associated with COVID-19: a case series. V/Q SPECT/CT can play a role in the management of patients hospitalized for COVID-19 for the diagnosis of embolic complications with meticulous hygienic precautions. 2020-06-22
Olfactory and gustatory dysfunctions due to the coronavirus disease (COVID-19): a review of current evidence. These findings may aid future research on the diagnosis, prevention, and treatment of COVID-19 consequences. 2020-06-22
Tracheostomy care and decannulation during the COVID-19 pandemic. A multidisciplinary clinical practice guideline. COVID-19 requires a radical rethink of many tenets of tracheostomy care, and controversy continues to exist regarding the optimal techniques to minimise risk to patients and healthcare workers. 2020-06-22
Purposeful surgical delay and the coronavirus pandemic: how will black breast cancer patients fare? Our recommendations to better characterize the impact of these guidelines on surgical delay among vulnerable populations include the following: (1) track time from biopsy-proven diagnosis to surgery by race and ethnicity, (2) document patient and institution-related reasons for surgical delay, (3) record patient and disease-related variables/reasons for the selection of breast conservation surgery, mastectomy, and reconstruction by race and ethnicity, and (4) collect data on impactful social determinants of health such as financial reserve, housing conditions, stress, and transportation. 2020-06-28
Coronavirus disease 2019 (COVID-19) in children: a systematic review of imaging findings. At diagnosis, 143/421 (34.0%) had a normal CT. 2020-06-22
Assessment of paediatric dental guidelines and caries management alternatives in the post COVID-19 period. A critical review and clinical recommendations. This paper also summarised the relevant evidence-based guidelines for the use of non-invasive and minimally invasive caries management techniques. 2020-06-22
COVID-19 and the elderly: insights into pathogenesis and clinical decision-making. Early diagnosis and individualized therapeutic management should be developed for elderly subjects based on personal medical history and polypharmacotherapy. 2020-06-22
Recognition of Natural Products as Potential Inhibitors of COVID-19 Main Protease (Mpro): In-Silico Evidences. With the aid of in silico techniques such as molecular docking and druggability studies, we have proposed several natural active compounds including glycyrrhizin, bicylogermecrene, tryptanthrine, β-sitosterol, indirubin, indican, indigo, hesperetin, crysophanic acid, rhein, berberine and β-caryophyllene which can be encountered as potential herbal candidate exhibiting anti-viral activity against SARS-CoV-2. 2020-06-22
Curative anticoagulation prevents endothelial lesion in COVID-19 patients. Adding D-dimers >500 ng/mL to gender and pneumonia at CT scan in ROC curve analysis significantly increased AUC for COVID-19 diagnosis. 2020-06-19
CT imaging features of COVID-19 pneumonia: initial experience from Turkey. One hundred and eighty-five patients (87 men, 98 women; mean age, 48.7 years), who underwent RT-PCR sampling and high-resolution CT examination in our hospital between March 15, 2020, and April 15, 2020, and got a definitive diagnosis of COVID-19 disease via initial or follow-up RT-PCR test, were included in the study. 2020-06-19
COVID-19 S: A new proposal for diagnosis and structured reporting of COVID-19 on computed tomography imaging. Because of the widespread use of CT in the diagnosis of COVID 19, indeterminate presentations such as single, few or unilateral lesions amount to a considerable number. […] We aimed to develop a new classification and structured reporting system on CT imaging (COVID-19 S) that would facilitate the diagnosis of COVID-19 in the most accurate way. […] The patients’ history, physical examination, CT findings, RT PCR, and other laboratory test results were reviewed, and a final diagnosis was made as COVID 19 or non-COVID 19. […] Chest CT scans were classified according to the COVID 19 S CT diagnosis criteria. […] Final clinical diagnosis was COVID-19 in 98 patients (12%). […] According to the COVID-19 S CT diagnosis criteria, the number of patients in the normal, compatible with COVID 19, indeterminate and alternative diagnosis groups were 581 (72.3%), 97 (12.1%), 16 (2.0%) and 109 (13.6%). […] When the indeterminate group was combined with the alternative diagnosis group, the sensitivity and specificity of COVID-19 S were 93.9% and 96.0%, with 94.8% PPV and 95.2% NPV. 2020-06-19
Canadian Public Health Laboratory Network Best Practices for COVID-19. Best practices for specimen collection, transportation, testing and biosafety are addressed from the perspective of Canadian public health laboratories to ensure a consistent approach across the country: Population-based testing for COVID-19 should initially be carried out for surveillanceNasopharyngeal swab is the specimen of choice for routine testingNucleic acid amplification tests (such as real-time reverse transcription polymerase chain reaction) are the method of choice for routine testing of SARS-CoV-2The decentralization of nucleic acid amplification testing for COVID-19 to hospital or other high complexity medical laboratories should be promoted to increase test capacity and meet increased demandsIn the early stages of the pandemic, positive (approximately 10-20) and negative (approximately 50) tests by a provincial laboratory require confirmation at the National Microbiology LaboratoryCo-circulation of other viral agents associated with influenza-like Illnesses (e.g. influenza A and B and respiratory syncytial virus) should be monitored as capacity permits, as part of ongoing surveillanceOnce validated, serological testing may be utilized for assessing the presence/absence of immune response to the SARS-CoV-2 at either the population or individual level for select indications, but is likely to be of limited utility in diagnosis of acute COVID-19 illness These recommendations will be updated as new information becomes available. 2020-06-22
Association of Angiotensin-Converting Enzyme Inhibitor or Angiotensin Receptor Blocker Use With COVID-19 Diagnosis and Mortality. To examine whether use of ACEI/ARBs was associated with COVID-19 diagnosis and worse outcomes in patients with COVID-19. […] Patients with COVID-19 from February 22 to May 4, 2020, were identified using ICD-10 codes and followed up from day of diagnosis to outcome or end of study period (May 4, 2020). […] To examine susceptibility to COVID-19, a Cox regression model with a nested case-control framework was used to examine the association between use of ACEI/ARBs vs other antihypertensive drugs and the incidence rate of a COVID-19 diagnosis in a cohort of patients with hypertension from February 1 to May 4, 2020. […] In the nested case-control susceptibility analysis, the outcome was COVID-19 diagnosis. […] Prior use of ACEI/ARBs was not significantly associated with COVID-19 diagnosis among patients with hypertension or with mortality or severe disease among patients diagnosed as having COVID-19. 2020-06-23
Beating the odds with systematic individualized care Nationwide prospective follow-up of all patients with COVID-19 in Iceland. The DOH and DCPEM, in close collaboration with the Department of Clinical Microbiology and Internal Medicine Services at Landspitali-The National University Hospital (LUH) and deCODE genetics, initiated a nationwide surveillance program for COVID-19, including diagnostic testing which began on 31 January. 2020-06-19
Developing a Fully-glycosylated Full-length SARS-CoV-2 Spike Protein Model in a Viral Membrane. First, starting from PDB:6VSB and 6VXX, full-length S protein structures were modeled using template-based modeling, de-novo protein structure prediction, and loop modeling techniques in GALAXY modeling suite. 2020-06-19
Performance Assessment of SARS-CoV-2 PCR Assays Developed by WHO Referral Laboratories. A reliable diagnostic assay is crucial to early detect new COVID-19 cases and limit severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) transmission. […] Since the onset of the COVID-19 pandemic, the World Health Organization has published several diagnostic molecular approaches developed by referral laboratories, including Charité (Germany), HKU (Hong Kong), China CDC (China), US CDC (United States), and Institut Pasteur, Paris (France). […] The data presented herein are of prime importance to facilitate the equipment choice of diagnostic laboratories, as well as for the development of marketed tests. 2020-06-22
COVID-19 Diagnostics, Tools, and Prevention. COVID-19 diagnosis and the prediction of virus transmission are analyzed by machine learning algorithms, simulations, and digital monitoring. 2020-06-22
Prevention of thrombotic risk in hospitalized patients with COVID-19 and hemostasis monitoring. In ICU patients, it is sometimes difficult to confirm a diagnosis of thrombosis, and curative anticoagulant treatment may also be discussed on a probabilistic basis. […] In all these situations, therapeutic doses of LMWH, or UFH in case of renal insufficiency with monitoring of anti-Xa activity, are proposed.In conclusion, intensification of heparin treatment should be considered in the context of COVID-19 on the basis of clinical and biological criteria of severity, especially in severely ill ventilated patients, for whom the diagnosis of pulmonary embolism cannot be easily confirmed. 2020-06-23
Positive results for patients with COVID-19 discharged form hospital in Chongqing, China. Multi-site screening of SARS-CoV-2 including nasal and pharyngeal swabs, stool and sputum specimens could be considered to improve the diagnosis, treatment and infection control in patients with COVID-19. 2020-06-23
Safety netting; best practice in the face of uncertainty. Safety netting is a recognised General Practitioner (GP) diagnostic strategy often used in the face of uncertainty to help ensure that a patient with unresolved or worsening symptoms knows when and how to access further advice. […] Screening for Red Flags and any indication of a serious cause of symptoms is always first line in any consultation, however, clinical presentations are not always black and white with patients falling into a clear diagnostic category. 2020-06-23
Epidemiology of COVID-19 in Mexico: from the 27th of February to the 30th of April 2020. On the 30th of April, 64 days after this first diagnosis, the number of patients had increased exponentially, reaching 19 224 confirmed cases and 1859 (9.67%) deaths. 2020-06-23
The close relationship between sudden loss of smell and COVID-19. Therefore, finding a symptom with a high predictive value would help in diagnostic and isolation strategies. […] To correlate the sudden loss of the sense of smell in the context of the COVID-19 pandemic with results of diagnostic tests for COVID-19. […] Total or partial sudden loss of the sense of smell showed high positive predictive value for COVID-19 diagnosis, during the COVID-19 pandemic in Brazil (88.8%). 2020-06-23