Treatment Sentence Context
Table 1. Analysis of context sentence of 16570 absracts clustered as Treatment
| PMID | Gene Context Sentence | ePubDate |
|---|---|---|
| 31944312 | Identification of the causative viral pathogens of respiratory tract viral infections is important to select an appropriate treatment, save people’s lives, stop the epidemics, and avoid unnecessary use of antibiotics. | 2020-03-19 |
| 31967265 | He received antibiotic treatment, as well as, transfusion, dialysis, hemodynamic, and ventilatory support. […] This case of severe YF with non-fatal outcome emphasizes the importance of adequate syndromic diagnosis, and early and aggressive supportive treatment that can save a patient’s life. | 2020-01-23 |
| 31981224 | In this review, we provide an update on CoV infections and relevant diseases, particularly the host defense against CoV-induced inflammation of lung tissue, as well as the role of the innate immune system in the pathogenesis and clinical treatment. | 2020-03-19 |
| 31986264 | We report the epidemiological, clinical, laboratory, and radiological characteristics and treatment and clinical outcomes of these patients. | 2020-03-13 |
| 31996494 | At present, there is no vaccine or antiviral treatment for human and animal coronavirus, so that identifying the drug treatment options as soon as possible is critical for the response to the 2019-nCoV outbreak. […] Three general methods, which include existing broad-spectrum antiviral drugs using standard assays, screening of a chemical library containing many existing compounds or databases, and the redevelopment of new specific drugs based on the genome and biophysical understanding of individual coronaviruses, are used to discover the potential antiviral treatment of human pathogen coronavirus. […] Lopinavir /Ritonavir, Nucleoside analogues, Neuraminidase inhibitors, Remdesivir, peptide (EK1), abidol, RNA synthesis inhibitors (such as TDF, 3TC), anti-inflammatory drugs (such as hormones and other molecules), Chinese traditional medicine, such ShuFengJieDu Capsules and Lianhuaqingwen Capsule, could be the drug treatment options for 2019-nCoV. | 2020-03-18 |
| 32017984 | Here, we focus on advances in research and development of fast diagnosis methods, as well as potential prophylactics and therapeutics to prevent or treat 2019-nCoV infection. | 2020-03-18 |
| 32020915 | Herein, we present on an overview of the currently available information on the pathogenesis, epidemiology, clinical presentation, diagnosis, and treatment of this virus. | 2020-04-13 |
| 32022370 | The spike protein used for host cell infection shows key nonsynonymous mutations that might hamper the efficacy of previously developed therapeutics but remains a viable target for the development of biologics and macrocyclic peptides. | 2020-03-18 |
| 32023681 | To standardize the diagnosis and treatment of this new infectious disease, operational guidelines for the diagnosis and management of 2019-nCoV infection is accomplished by Peking Union Medical College Hospital. | 2020-02-05 |
| 32023682 | The outbreak of pneumonia caused by the novel coronavirus 2019-nCoV in Wuhan, Hubei province of China, at the end of 2019 shaped tremendous challenges to China’s public health and clinical treatment. | 2020-02-05 |
| 32023684 | Based on current studies, the author summarized the clinical characteristics and evolution of the novel viral pneumonia, and proposed the key points of diagnosis and treatment, the scientific management of both confirmed and suspected cases, and the scientific management of disease prevention and control. | 2020-02-05 |
| 32026148 | Following the latest National recommendations for diagnosis and treatment of pneumonia caused by 2019-nCoV (the 4th edition) and current status of clinical practice in Zhejiang Province, recommendations for the diagnosis and treatment of respiratory infection caused by 2019-nCoV for children were drafted by the National Clinical Research Center for Child Health, the National Children’s Regional Medical Center, Children’s Hospital, Zhejiang University School of Medicine to further standardize the protocol for diagnosis and treatment of respiratory infection in children caused by 2019-nCoV. | 2020-02-06 |
| 32027631 | Although these measures might not prevent the eventual establishment of ongoing, widespread transmission of the virus in the United States, they are being implemented to 1) slow the spread of illness; 2) provide time to better prepare health care systems and the general public to be ready if widespread transmission with substantial associated illness occurs; and 3) better characterize 2019-nCoV infection to guide public health recommendations and the development of medical countermeasures including diagnostics, therapeutics, and vaccines. | 2020-02-07 |
| 32029004 | For it is a never been experienced respiratory disease before and with infection ability widely and quickly, it attracted the world’s attention but without treatment and control manual. […] This guideline includes the guideline methodology, epidemiological characteristics, disease screening and population prevention, diagnosis, treatment and control (including traditional Chinese Medicine), nosocomial infection prevention and control, and disease nursing of the 2019-nCoV. […] Moreover, we also provide a whole process of a successful treatment case of the severe 2019-nCoV infected pneumonia and experience and lessons of hospital rescue for 2019-nCoV infections. | 2020-03-19 |
| 32031570 | Epidemiological, demographic, clinical, laboratory, radiological, and treatment data were collected and analyzed. […] Most patients received antiviral therapy (oseltamivir, 124 [89.9%]), and many received antibacterial therapy (moxifloxacin, 89 [64.4%]; ceftriaxone, 34 [24.6%]; azithromycin, 25 [18.1%]) and glucocorticoid therapy (62 [44.9%]). […] Of the 36 cases in the ICU, 4 (11.1%) received high-flow oxygen therapy, 15 (41.7%) received noninvasive ventilation, and 17 (47.2%) received invasive ventilation (4 were switched to extracorporeal membrane oxygenation). | 2020-03-13 |
| 32033513 | the National Health Commission of the People’s Republic of China publish the guidelines for the diagnosis and treatment of novel coronavirus (2019-nCoV) infection (trial version 5) . | 2020-02-08 |
| 32034659 | This statement is based on the Novel Coronavirus Infection Pneumonia Diagnosis and Treatment Standards (the fourth edition) (National Health Committee) and other previous diagnosis and treatment strategies for pediatric virus infections. […] The present consensus statement summarizes current strategies on diagnosis, treatment, and prevention of 2019-nCoV infection in children. | 2020-02-08 |
| 32035428 | At present, the prevention and treatment of 2019 Novel Coronavirus (2019-nCoV) in China has reached a critical stage. | 2020-02-08 |
| 32037389 | No effective antiviral treatment has been verified thus far. […] All the patients were given antiviral treatment including lopinavir/ritonavir (Kaletra®), arbidol, and Shufeng Jiedu Capsule (SFJDC, a traditional Chinese medicine) and other necessary support care. […] After treatment, three patients gained significant improvement in pneumonia associated symptoms, two of whom were confirmed 2019-nCoV negative and discharged, and one of whom was virus negative at the first test. […] Results obtained in the current study may provide clues for treatment of 2019-nCoV pneumonia. […] The efficacy of antiviral treatment including lopinavir/ritonavir, arbidol, and SFJDC warrants further verification in future study. | 2020-03-18 |
| 32040667 | Oseltamivir is the most widely used neuraminidase inhibitor for treatment of influenza; data suggest that early use is associated with reduced mortality in critically ill patients with influenza. […] Limited existing knowledge highlights the need for data regarding supportive care and adjunctive pharmacologic therapy that is specific for critically ill patients with severe RVI. […] There is a need for more pragmatic and efficient designs to test different therapeutics both individually and in combination. | 2020-03-18 |
| 32044814 | This study aims to investigate its epidemiologic history, and analyze the clinical characteristics, treatment regimens, and prognosis of patients infected with 2019-nCoV during this outbreak. […] Clinical data from 137 2019-nCoV-infected patients admitted to the respiratory departments of the respiratory departments of nine tertiary hospitals in Hubei province from December 30, 2019 to January 24, 2020 were retrospectively collected, including general status, clinical manifestations, laboratory test results, imaging characteristics, and treatment regimens. […] Given the lack of effective drugs, treatment focused on symptomatic and respiratory support. […] Systemic corticosteroid treatment did not show significant benefits. | 2020-03-02 |
| 32048163 | Our results suggest a number of potential diagnosis biomarkers and angiotensin receptor blocker (ARB) drugs for potential repurposing treatment of 2019-nCoV infection. | 2020-03-19 |
| 32049687 | Currently, there is no definite treatment for SSCP although some drugs are under investigation. | 2020-02-12 |
| 32051071 | The perinatal-neonatal departments should cooperate closely and take integrated approaches, and the neonatal intensive care unit should prepare the emergency plan for 2019-nCoV infection as far as possible, so as to ensure the optimal management and treatment of potential victims. | 2020-02-19 |
| 32051072 | During the epidemic of 2019-nCoV, the emergency response plan for the NICU should be based on the actual situation, including diagnosis, isolation, and treatment, as well as available equipment and staffing, and take into account the psychosocial needs of the families and neonatal care staff. | 2020-02-19 |
| 32051073 | In order to further standardize and enhance the clinical management of 2019-nCoV infection in children, reduce the incidence, and decrease the number of severe cases, we have formulated this diagnosis and treatment recommendation according to the recent information at home and abroad. | 2020-02-19 |
| 32052466 | In the absence of treatment for this virus, there is an urgent need to find alternative methods to control the spread of disease. […] Here, we have conducted an online search for all treatment options related to coronavirus infections as well as some RNA-virus infection and we have found that general treatments, coronavirus-specific treatments, and antiviral treatments should be useful in fighting COVID-19. | 2020-03-18 |
| 32054787 | Here, we tested the efficacy of prophylactic and therapeutic remdesivir treatment in a nonhuman primate model of MERS-CoV infection, the rhesus macaque. […] Prophylactic remdesivir treatment initiated 24 h prior to inoculation completely prevented MERS-CoV-induced clinical disease, strongly inhibited MERS-CoV replication in respiratory tissues, and prevented the formation of lung lesions. […] Therapeutic remdesivir treatment initiated 12 h postinoculation also provided a clear clinical benefit, with a reduction in clinical signs, reduced virus replication in the lungs, and decreased presence and severity of lung lesions. […] The data presented here support testing of the efficacy of remdesivir treatment in the context of a MERS clinical trial. | 2020-04-01 |
| 32057209 | We here share the therapeutic experiences of NCP treatment with literature review. | 2020-02-14 |
| 32060789 | With high human-to-human transmission rate (R0), 2019-nCoV has quickly spread in China and other countries, resulting in 34,953 confirmed cases and 725 deaths as of 8 February 2020, thus calling for urgent development of therapeutics and prophylactics. | 2020-02-15 |
| 32061198 | At present, there is no definite and effective treatment for COVID-19. | 2020-02-15 |
| 32061199 | Respiratory support is the most important therapy for SARI patients with respiratory failure. | 2020-02-16 |
| 32061200 | After 3 to 5 days of treatment, 2019-nCoV nucleic acid in a second respiratory sample turned negative in 6 cases. | 2020-02-16 |
| 32064854 | Residents have a high awareness rate of the main symptoms, transmission routes, using of masks, hand washing and treatment information of NCP, while a low awareness rate of the atypical symptoms. | 2020-02-17 |
| 32064855 | Among the 7 patients, 1 case died of (B) aggravation, and the other patients’ condition was effectively controlled after active treatment. | 2020-02-17 |
| 32065055 | Currently, however, there is no specific antiviral treatment or vaccine. […] These results suggest that CR3022 may have the potential to be developed as candidate therapeutics, alone or in combination with other neutralizing antibodies, for the prevention and treatment of 2019-nCoV infections. | 2020-03-16 |
| 32065348 | Historical records on prevention and treatment of infections in CM classics, clinical evidence of CM on the prevention of severe acute respiratory syndrome (SARS) and H1N1 influenza, and CM prevention programs issued by health authorities in China since the COVID-19 outbreak were retrieved from different databases and websites till 12 February, 2020. | 2020-04-03 |
| 32072919 | This guideline is applicable to the health protection requirements of large indoor stadiums which are reconstructed as treatment sites for the Novel Coronavirus Pneumonia (NPC) patients with mild symptoms during the outbreak. | 2020-02-19 |
| 32074550 | The coronavirus disease 2019 (COVID-19) virus is spreading rapidly, and scientists are endeavoring to discover drugs for its efficacious treatment in China. […] Chloroquine phosphate, an old drug for treatment of malaria, is shown to have apparent efficacy and acceptable safety against COVID-19 associated pneumonia in multicenter clinical trials conducted in China. […] The drug is recommended to be included in the next version of the Guidelines for the Prevention, Diagnosis, and Treatment of Pneumonia Caused by COVID-19 issued by the National Health Commission of the People’s Republic of China for treatment of COVID-19 infection in larger populations in the future. | 2020-03-18 |
| 32074786 | As surgeons specialized in the treatment of gastrointestinal tumors, we should always be aware of the prevention for NCP and incorporate this awareness into every detail of clinical practice. […] For malignant tumor, multidisciplinary therapy (MDT) is recommended and non-surgical anti-tumor therapy should be selected with higher priority. […] Neoadjuvant therapy is highly recommended for gastrointestinal cancer at advanced stages that meet the indications of NCCN guideline (gastric cancer T stage ≥ 2/rectal cancer T stage ≥ 3/unresectable colon cancer). […] However, emergency operation still must be performed for patients with acute uncontrolled bleeding, obstruction or after other alternative treatment measures fail. | 2020-03-12 |
| 32075365 | Here we found that treating the patients diagnosed as novel coronavirus pneumonia with chloroquine might improve the success rate of treatment, shorten hospital stay and improve patient outcome. […] In order to guide and regulate the use of chloroquine in patients with novel coronavirus pneumonia, the multicenter collaboration group of Department of Science and Technology of Guangdong Province and Health Commission of Guangdong Province for chloroquine in the treatment of novel coronavirus pneumonia developed this expert consensus after extensive discussion. | 2020-02-20 |
| 32077440 | For patients with lung occupying lesions, the whole process of diagnosis and treatment can not be carried out as usual due to the epidemic. […] All thoracic surgeons in China should work together to develop the proper procedures for the diagnosis and treatment in this special situation, and continuously update the recommendations based on epidemic changes and further understanding of COVID-19. | 2020-03-16 |
| 32077441 | With the spread of COVID-19, the routine clinical diagnosis and treatment for lung cancer patients has been disturbed. […] During the COVID-19 outbreak period, it should be carefully differentiated for fever and respiratory symptoms for lung cancer patients receiving anti-tumor treatment, in order to evaluate the risk of COVID-19. | 2020-03-16 |
| 32077660 | Clinical classification (mild, moderate, severe, and critical) was carried out according to the diagnosis and treatment program of novel coronavirus pneumonia (Trial Fifth Edition) issued by the National Health Commission. […] ALT, AST, ALB and TBil of the severe or critical subgroups were 60.25 (40.88 ~ 68.90) U/L, 37.00 (20.88 ~ 64.45) U/L, 35.75 (28.68 ~ 42.00) g/L, and 20.50 (11.28 ~ 25.00) mmol/L, respectively. Conclusion: The results of this multicenter retrospective study suggests that novel coronavirus pneumonia combined with liver damage is more likely to be caused by adverse drug reactions and systemic inflammation in severe patients receiving medical treatment. […] Therefore, liver function monitoring and evaluation should be strengthened during the treatment of such patients. 目的： 分析新型冠状病毒肺炎病例的临床特征，初步探讨不同临床分型与肝功能损伤的关系。 | 2020-02-20 |
| 32077661 | As such, we developed this consensus recommendations on all those high-risk treatments, based on the current evidence as well as the resource limitation in some areas, with the aim to reduce the nosocomial transmission and optimize the treatment for the COVID-19 pneumonia patients. […] Those recommendations include: (1) Standard prevention and protection, and patient isolation; (2) Patient wearing mask during HFNC treatment; (3) Using dual limb ventilator with filters placed at the ventilator outlets, or using heat-moisture exchanger (HME) instead of heated humidification in single limb ventilator with HME placed between exhalation port and mask; avoid using mask with exhalation port on the mask; (4) Placing filter between resuscitator and mask or artificial airway; (5) For spontaneous breathing patients, placing mask for patients during bronchoscopy examination; for patients receiving noninvasive ventilation, using the special mask with bronchoscopy port to perform bronchoscopy; (6) Using sedation and paralytics during intubation, cuff pressure should be maintained between 25-30 cmH(2)O; (7) In-line suction catheter is recommended and it can be used for one week; (8) Dual-limb heated wire circuits are recommended and only changed with visible soiled; (9. […] (11) Avoid unnecessary bronchial hygiene therapy; (12) For patients who need aerosol therapy, dry powder inhaler metered dose inhaler with spacer is recommended for spontaneous breathing patients; while vibrating mesh nebulizer is recommended for ventilated patients and additional filter is recommended to be placed at the expiratory port of ventilation during nebulization. | 2020-02-20 |
| 32078069 | According to the current status, blocking transmission, isolation, protection, and alternative medication are the urgent management strategies against 2019-nCoV. | 2020-03-06 |
| 32079150 | The mean time from illness onset to hospital admission (for treatment and/or isolation) was estimated at 3-4 days without truncation and at 5-9 days when right truncated. | 2020-03-20 |
| 32080994 | Complying with overall requirements of the government and regulations on public health emergences, as well as the clinical features of diagnosis and treatment of dental illness, this paper refers to previous guidelines and studies on the infection prevention and control in dental diagnosis and treatment in China and foreign countries. | 2020-02-21 |
| 32084675 | By summarizing the research progress and guidelines in recent years in the fields of colorectal cancer disease screening, treatment strategies(including early colorectal cancer, locally advanced colorectal cancer, obstructive colorectal cancer, metastatic colorectal cancer and the treatment of patients after neoadjuvant therapy), the choice of medication and time limit for adjuvant therapy, the protective measures for patients undergoing emergency surgery, the re-examination of postoperative patients and the protection of medical staff, etc., authors improve treatment strategies in order to provide more choices for patients to obtain the best treatment under the severe epidemic situation of new coronavirus pneumonia. […] Meanwhile we hope that it can also provide more timely treatment modeling schemes for colleagues. | 2020-02-22 |
| 32084676 | Referring to the “Diagnosis and Treatment Scheme for NCP (Trial Version 4 and 5)” and combining the actual practice situation in our hospital with the “Summary of New Coronavirus Files of Shanghai Renji Hospital”, we summarize how to carry out the clinical practice of colorectal surgery under the situation of the prevention and control of the NCP epidemiology, meanwhile under such situation aiming the procedure of diagnose and treatment for emergency patients with colorectal tumor, we share the experiences of the diagnosis of colorectal tumor, the management of patients with colorectal cancer who are scheduled to be admitted for surgery, the protection of wards, the perioperative management. […] The main points are as follows: (1) Multidisciplinary team (MDT) must be run through the diagnosis and treatment of colorectal cancer. | 2020-02-22 |
| 32086886 | The outbreak of the novel coronavirus has affected the normal diagnosis and treatment services in oral medical institutions across the country. […] Delay of non-emergency dental service will have a potential impact on the experience, cognition, treatment and rehabilitation of patients with oral diseases. […] At the same time, this paper analyzes the possible psychological stress symptoms of patients with different oral diseases, and puts forward suggestions for remote consultation and emergency treatment of dentists. | 2020-02-22 |
| 32086938 | Utilizing the Centers for Disease Control and Prevention (CDC, USA) website, and a comprehensive review of PubMed literature, we obtained information regarding clinical signs and symptoms, treatment and diagnosis, transmission methods, protection methods and risk factors for Middle East Respiratory Syndrome (MERS), Severe Acute Respiratory Syndrome (SARS) and COVID-19. | 2020-02-22 |
| 32087334 | Herein, we describe the epidemic and etiological characteristics of 2019-nCoV, discuss its essential biological features, including tropism and receptor usage, summarize approaches for disease prevention and treatment, and speculate on the transmission route of 2019-nCoV. | 2020-03-18 |
| 32087621 | We will share the treatment experience of severe NCP with the first-line treatment experience. […] In addition, there is up regulation of inflammatory factors in patients with severe NCP, but the effect of renal replacement therapy needs to be further confirmed by clinical research. | 2020-02-23 |
| 32087622 | It is an unavoidable fact that the patients with chronic wounds have to go to the hospital for treatment prescribed by the physician. […] At the same time, we found that quite a few patients preferred going far afield in choosing hospital for treatment due to various reasons. […] During the prevention and control of coronavirus epidemic, this " go far afield" style of seeking medical treatment may increase the exposure risk during travelling. […] Accordingly, we convened 36 wound care clinics in different regions in Shanghai to implement the " Five Measures" encouraging the patients with chronic wounds to seek medical treatment nearby. […] The principle of this operation is that when seeking medical treatment, patients with chronic wounds should try their best to reduce the travel distance as much as possible to minimize the exposure risk during the epidemic period, which will in turn support the campaign of epidemic prevention and control. | 2020-02-24 |
| 32088333 | These measures were motivated by the need to provide effective treatment of patients, and involved consultation with three major groups in policy formulation-public health experts, the government, and the general public. | 2020-03-18 |
| 32092748 | This issue has rapidly reviewed and published articles describing COVID-19, including the drug treatment options for SARS-CoV-2, its clinical characteristics, and therapies involving a combination of Chinese and Western medicine, the efficacy of chloroquine phosphate in the treatment of COVID-19 associated pneumonia according to clinical studies, and reflections on the system of reserve medical supplies for public health emergencies. | 2020-03-18 |
| 32093211 | Meanwhile, it is also crucial to speed up the development of vaccines and drugs for treatment, which will enable us to defeat COVID-19 as soon as possible. | 2020-03-22 |
| 32096366 | The chest CT images of patients with COVID-19 have certain characteristics with dynamic changes, which are of value for monitoring disease progress and clinical treatment. | 2020-03-16 |
| 32096367 | Based on the present expert consensus carried out by National Health Commission and National Administration of Traditional Chinese Medicine, our team summarized and established an effective treatment strategy centered on “Four-Anti and Two-Balance” for clinical practice. […] Meanwhile, integrated multidisciplinarypersonalized treatment was recommended to improve therapeutic effect. […] Early antiviral treatment could alleviate disease severity and prevent illness progression, and we found lopinavir/ritonavir combined with abidol showed antiviraleffects in COVID-19. […] The artificial liver blood purification system could rapidly remove inflammatory mediators and block cytokine storm.Moreover, it also favoredthe balance of fluid, electrolyte and acid-base and thus improved treatment efficacy in critical illness. […] Conservative oxygen therapy was preferred and noninvasive ventilation was not recommended. […] We also integrated Chinese medicine in treatment to promote disease rehabilitation through classification methods of traditional Chinese medicine. […] However, since COVID-19 was a newly emerging disease, more work was warranted to improve strategies of prevention, diagnosis and treatment for COVID-19. | 2020-03-16 |
| 32096395 | The characteristics including high contagiousness, herd susceptibility and clinical phenotype diversity, made a serious influence on people’s daily life and rountine therapy for other diseases. […] In the central epidemic area of COVID-19, Hubei province, especially Wuhan, the clinical specialists of breast diseases should consider all of the following factors comprehensively: the prevention of COVID-19, the diagnosis and treatment of breast diseases and the accessibility of medical resources. […] Besides, we should select the appropriate therapy and optimize treatment process so as to prevent the propagation and cross infection of COVID-19 as well as manage the breast diseases without delay. […] Therefore, we carried out some management proposals of the patients with breast diseases in the central epidemic area during the epidemic of COVID-19 on the basis of conventional treatment guidelines and clinical experiences. | 2020-02-25 |
| 32096396 | After the outbreak of this disease, the overwhelming majority of cities have launched the “first level response” and the regular diagnosis and treatment of cancer patients are greatly affected. […] The epidemic of novel coronavirus pneumonia poses new challenges to diagnosis and treatment of the patients with digestive system malignancies. […] Based on the fully understanding of the characteristics of digestive system tumors, we should change the treatment strategy and adopt more reasonable treatment strategy timely during the epidemic period to minimize the adverse effects of the epidemic of novel coronavirus pneumonia on the treatment. | 2020-02-25 |
| 32098302 | The collaborative efforts of researchers are needed to fill the knowledge gaps about this new virus, to develop the proper diagnostic tools, and effective treatment to combat this infection. | 2020-02-26 |
| 32098422 | The goal of this work is to systematically review and compare between SARS-CoV and SARS-CoV-2 in the context of their virus incubation, originations, diagnosis and treatment methods, genomic and proteomic sequences, and pathogenic mechanisms. | 2020-03-23 |
| 32098466 | According to " the Diagnosis and Treatment of New Coronavirus Pneumonia "(6th edition) of the National Health Commission of the People’s Republic of China, a new guideline for the diagnosis and treatment of 2019 novel coronavirus infection suitable for the military (first trial version) was established. […] Some unique opinions and suggestions are put forward in terms of disease name, diagnosis criteria, antiviral treatment, glucocorticoid application, etc. […] This article will make a proper interpretation in order to understand the guideline better and help guide the diagnosis and treatment of diseases. | 2020-02-26 |
| 32100486 | After treatment, the lesions were shown to be almost absorbed leaving the fibrous lesions. | 2020-03-24 |
| 32100979 | In order to prevent cluster outbreaks, the government strengthened the management and control of personnel mobility, which had a great impact on the examination and treatment of breast cancer patients. […] If necessary, after professional discussion and communication between doctors and patients online or offline, the hospital visiting time should be delayed through seeking alternative treatment schemes, and psychological counseling for patients should be paid attention to at the same time. | 2020-02-26 |
| 32100980 | The outbreak of novel coronavirus pneumonia (NCP) makes the medical treatment of colorectal cancers difficult. […] For metastatic colorectal cancer (CRC) patients, maintenance therapy is the optimal choice. […] Adjuvant chemotherapy should reduce the intensity of treatment and shorten the therapy time. | 2020-02-26 |
| 32102777 | In this report, we provide comprehensive descriptions on data deposition, management, release and utility in 2019nCoVR, laying important foundations in aid of studies on virus classification and origin, genome variation and evolution, fast detection, drug development and pneumonia precision prevention and therapy. | 2020-03-12 |
| 32104915 | Awareness of this may have a guiding significance for the prevention and treatment of the SARS-CoV-2-induced respiratory failure. | 2020-03-18 |
| 32104917 | There is an urgent need for an accurate and rapid test method to quickly identify a large number of infected patients and asymptomatic carriers to prevent virus transmission and assure timely treatment of patients. | 2020-04-13 |
| 32105052 | It has also brought great challenges to the treatment of patients with cancer. […] The selection of surgical procedures and perioperative managements of esophageal cancer require all thoracic surgeons work together to figure out a reasonable system of surgical treatment and emergency response. | 2020-02-27 |
| 32105680 | Principles of management of coronavirus disease 2019 in pregnancy include early isolation, aggressive infection control procedures, oxygen therapy, avoidance of fluid overload, consideration of empiric antibiotics (secondary to bacterial infection risk), laboratory testing for the virus and coinfection, fetal and uterine contraction monitoring, early mechanical ventilation for progressive respiratory failure, individualized delivery planning, and a team-based approach with multispecialty consultations. | 2020-04-15 |
| 32106216 | Although these measures might not prevent widespread transmission of the virus in the United States, they are being implemented to 1) slow the spread of illness; 2) provide time to better prepare state and local health departments, health care systems, businesses, educational organizations, and the general public in the event that widespread transmission occurs; and 3) better characterize COVID-19 to guide public health recommendations and the development and deployment of medical countermeasures, including diagnostics, therapeutics, and vaccines. | 2020-03-02 |
| 32107909 | Objective: To explorethe proper protective measures for pancreaticdiseases treatment during theoutbreak of 2019 coronavirus disease(COVID-19). Method: Clinical data of four cases of patients that suffered COVID-19from February 2(nd), 2020 to February 9(th), 2020 in pancreatic surgery were reviewed.After the first patientscuffednosocomial infection of COVID-19, the general protective measures in our department wereupdated.Only one patient was admitted to each room alone, with no more than one caregiver.The body temperature of care givers was measuredtwice a day.Primary protections were applied to all staff.The floor was sterilized using disinfectant with an effective chlorine concentration of 1000 mg/L.The protective measures for interventional procedures were as follow.Primary protection was applied to the operators ofcentral venipuncture catheter, percutaneous abdominal/pleural drainage, percutaneous retroperitoneal drainage, percutaneous transhepatic cholangial drainage and other surgical procedures with local anesthesiaand epidural anesthesia.Secondary protection was applied to the operators of endoscopic retrograde cholangiopancreatography and surgical procedures with general anesthesia. Results: During Feb 2(nd), 2020 to Feb 9(th), 2020, four patients in our department were diagnosed with COVID-19, of which one was died of COVID-19, two were cured, and one is still in hospital for COVID-19. | 2020-02-28 |
| 32108351 | We aim to summarize reliable evidence of evidence-based medicine for the treatment and prevention of the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) by analyzing all the published studies on the clinical characteristics of patients with SARS-CoV-2. | 2020-03-18 |
| 32108352 | With more and more patients diagnosed, China has carried out more than 100 clinical studies of new coronavirus infection, including antiviral drugs, antimalarial drugs, glucocorticoids, plasma therapy, virus vaccine, and other Western drugs, while Chinese medicine research accounted for half of the studies. […] Although the final results of studies will take a long time to complete, the interim research data may provide some help for the current urgent demand for drug treatment. | 2020-03-05 |
| 32108459 | In addition to supporting the frontline actively, medical workers in general surgery spare no efforts in making good diagnosis and treatment of specialized diseases by optimizing treatment process, providing medical advice online, mastering indications of delayed operation and emergency operation reasonably, etc. […] However, instead of continuing the traditional treatment, a new management system should be developed. […] Based on the characteristics of Budd-Chiari syndrome patients in China and our experience, we divide the patients into ordinary and critical cases, and treatment strategies suitable for the epidemic period of COVID-19 are put forward for reference and discussion by physicians. | 2020-02-28 |
| 32108460 | During the epidemic period, the routine diagnosis and treatment of tumor patients was affected with varying degrees. […] In this special period, we performed the superiority of the multi-disciplinary team of diagnosis and treatment, achieved accurate diagnosis and treatment of patients with hepatobiliary malignant tumors, provided support for these patients with limited medical resources, and helped them to survive during the epidemic period.On the basis of fully understanding the new coronavirus pneumonia, the treatment strategy should be changed timely during the epidemic, and more appropriate treatment methods should be adopted to minimize the adverse effect of the epidemic on tumor treatment. | 2020-02-28 |
| 32109443 | A retrospective analysis was performed on the imaging findings of patients confirmed with COVID-19 pneumonia who had chest CT scanning and treatment after disease onset. […] CT scanning provides important bases for early diagnosis and treatment of NCP. | 2020-04-06 |
| 32110875 | Rapid diagnostics, vaccines and therapeutics are important interventions for the management of the 2019 novel coronavirus (2019-nCoV) outbreak. […] A number of novel compounds as well as therapeutics licensed for other conditions appear to have in vitro efficacy against the 2019-nCoV. | 2020-04-11 |
| 32111113 | The treatment of critically ill patients with coronavirus disease 2019(COVID-19) faces compelling challenges. […] In this issue, we’d like to share our first-line treatment experience in treating COVID-19. […] Nutritional support is the basis of treatment. […] It’s important to establish individual therapy regimens and to evaluate, monitor and adjust dynamically. | 2020-02-29 |
| 32111114 | China has formally included the 2019-nCoV in the statutory notification and control system for infectious diseases according to the Law of the People’s Republic of China on the Prevention and Treatment of Infectious Diseases. […] According to the guidelines on the diagnosis and treatment of COVID-19 (6(th) trial edition), the latest relative literature at home and abroad, the features of the COVID-19, recommendations for the COVID-19 prevention and control issued by the National Health Commission of China, and management experience of diagnosis and treatment in the related disciplines, we put forward recommendations for the medical practices of burn treatment during the outbreak of the COVID-19 in outpatient and emergency treatment, inpatient treatment, operation and ward management, etc. […] We hope these recommendations could benefit the professionals of the same occupation as us and related hospital managers, improve the treatment of burn during the outbreak of the COVID-19, and avoid or reduce the risk of infection of medical staff . | 2020-02-29 |
| 32112549 | Since the outbreak of novel coronavirus pneumonia in December 2019, the diagnosis and treatment of patients with cancer have been facing great challenges. […] Although oncologists are not fighting on the front line to against the epidemic, during this special period, we should not only protect patients, their families and medical staff from the infection of novel Coronavirus, but also minimize the impact of the epidemic on the diagnosis and the treatment of patients with cancer. […] Combining the guidelines for diagnosis and treatment of tumors with our clinical experience, in this epidemic period, we discuss the strategies for diagnosis, treatment, and follow-up of malignant tumors of the digestive system in this article. | 2020-02-29 |
| 32112886 | By Feb 10, 2020, 262 patients were transferred from the hospitals across Beijing to the designated hospitals for special treatment of the COVID-19 infected by Beijing emergency medical service. | 2020-04-06 |
| 32114744 | By the end of February 25, 2020, none of the three patients developed severe 2019-nCoV pneumonia or died(two patients had been cured and discharged, while another one had been transferred to a square cabin hospital for isolation treatment). | 2020-03-02 |
| 32114747 | Corona Virus Disease 2019 (COVID-19) has seriously affected the treatment of patients and social stability. […] At present, some therapies such as interleukin-6 antibody blocker, stem cell therapy, and transfusion of convalescent plasma have been applied to counteract the cytokine storm and have made some progress. | 2020-03-02 |
| 32115733 | The treatment strategy for children with Coronavirus disease (COVID-19) is based on adult experience. | 2020-03-16 |
| 32117569 | While vaccine research should be pursued intensely, there exists today no therapy to treat 2019-nCoV upon infection, despite an urgent need to find options to help these patients and preclude potential death. […] I consider the options of drug repurposing, developing neutralizing monoclonal antibody therapy, and an oligonucleotide strategy targeting the viral RNA genome, emphasizing the promise and pitfalls of these approaches. […] Finally, I advocate for the fastest strategy to develop a treatment now, which could be resistant to any mutations the virus may have in the future. […] Such a treatment could help infected patients before a protective vaccine is developed and widely available in the coming months to year(s). | 2020-03-20 |
| 32118389 | Objective: To analyze the epidemiological history, clinical manifestations, treatment and the short-term prognosis of 31 cases of 2019 novel coronavirus(2019-nCoV) infection in children from six provinces (autonomous region) in northern China. Methods: A retrospective analysis of the epidemiological history, clinical symptoms, signs, laboratory examinations, chest imaging, treatment and the short-term prognosis of 31 cases of 2019-nCoV was conducted. […] After receiving supportive treatment, the viral nucleic acid turned negative in 25 cases within 7-23 days. […] After general treatment, the short-term prognosis is good. 目的： 分析中国北方6省（自治区）儿童2019新型冠状病毒（2019 novel coronavirus, 2019-nCoV）感染者的流行病学史、临床表现、治疗及近期预后。 | 2020-03-02 |
| 32118391 | For those patients who can’t completely deoxygenate for a long time after hospitalization, individualized treatment methods and different discharge evaluation criteria should be adopted to ensure the complete cure of patients and prevent recurrencing after discharge from hospital. | 2020-03-02 |
| 32118394 | The diagnosis and treatment of lung cancer patients have been challenged greatly because of extraordinary public health measures since the lung cancer patients are a high-risk population during the COVID-19 outbreak period. | 2020-03-02 |
| 32118639 | The effects of cluster of differentiation 4 (CD4)+ T lymphocytes, inflammatory indicators, and glucocorticoid treatment on viral nucleic acid clearance were analyzed. […] In the 292 confirmed cases, 66 patients recovered after treatment and were included in our study. […] After in-hospital treatment, patients’ inflammatory indicators decreased with improved clinical condition. […] The duration of viral RNA detection from oropharyngeal swabs and fecal samples in the glucocorticoid treatment group was longer than that in the non-glucocorticoid treatment group (15 days vs. […] 8.0 days, respectively; t = 2.550, P = 0.013) and the duration of viral RNA detection in fecal samples in the glucocorticoid treatment group was longer than that in the non-glucocorticoid treatment group (20 days vs. 11 days, respectively; t = 4.631, P < 0.001). […] Because of the delayed clearance of viral RNA in the glucocorticoid treatment group, glucocorticoids are not recommended in the treatment of COVID-19, especially for mild disease. | 2020-03-02 |
| 32118640 | Associated results will be used to evaluate the prognosis and to find the optimal treatment regimens for COVID-19 pneumonia. | 2020-03-02 |
| 32120458 | There was no significant difference in the proportion of ACEI/ARB medication between the critical group and the general group or between non-survivors and survivors (all P>0.05). Conclusion: COVID-19 patients combined with CVD are associated with a higher risk of mortality. | 2020-03-02 |
| 32120929 | Strobilanthes cusia (Nees) Kuntze is a Chinese herbal medicine used in the treatment of respiratory virus infections. | 2020-03-03 |
| 32125130 | In order to achieve the overall victory of the 2019 novel coronavirus disease epidemic in this ‘war’, especially to prevent the disease recurrence from rebounding during the resumption of labor, the government has not loosened any control of personnel mobility, which has obviously affected the normal examination and treatment of lung cancer patients under the influence of this epidemic. […] It is necessary to provide more appropriate individualized treatment recommendations for patients with lung cancer based on the epidemic situation of the patient’s location and in combination with the patient’s own condition. […] Through active prevention of infection, timely conversion of treatment strategies, online and offline joint control, and positive psychological counseling, we significantly hope to help patients with lung cancer to survive this difficult period. | 2020-03-03 |
| 32125132 | During the epidemic of COVID-19, We recommended that patients with advanced NSCLC should be treated as outpatients as possible at the nearest medical center; Patients who need to be hospitalized for antitumor treatment should be excluded from COVID-19 infection; More intensive attention should be paid to identification of COVID-19-related symptoms and adverse reactions caused by the malignancy or antitumor treatments. […] Stronger personal protection should be made for advanced NSCLC patients; An intentional postponing of antitumor treatment should be considered according to patient performance status. […] Treatment strategies should be made according to different types of advanced NSCLC patients and efficacy and toxicity of drugs. | 2020-03-03 |
| 32125140 | The recent outbreak of coronavirus disease 2019 (COVID-19) highlights an urgent need for therapeutics. […] In this brief review, we summarize the broad antiviral activity of niclosamide and highlight its potential clinical use in the treatment of COVID-19. | 2020-04-09 |
| 32125362 | Clinical course was summarized, including requirement for supplemental oxygen and intensive care and use of empirical treatment with lopinavir-ritonavir. […] Some patients required supplemental oxygen and had variable clinical outcomes following treatment with an antiretroviral agent. | 2020-03-17 |
| 32125642 | Currently there is no effective antiviral therapy for SARS-CoV-2 infection, which frequently leads to fatal inflammatory responses and acute lung injury. […] In the absence of a proven clinical FcR blocker, the use of intravenous immunoglobulin to block FcR activation may be a viable option for the urgent treatment of pulmonary inflammation to prevent severe lung injury. […] Such treatment may also be combined with systemic anti-inflammatory drugs or corticosteroids. | 2020-03-03 |
| 32129518 | Therapeutics that may assist to contain its rapid spread and reduce its high mortality rates are urgently needed. […] A tentative suggestion based on existing therapeutics, which would likely be resistant to new coronavirus mutations, is to use available angiotensin receptor 1 (AT1R) blockers, such as losartan, as therapeutics for reducing the aggressiveness and mortality from SARS-CoV-2 virus infections. […] This commentary elaborates on the idea of considering AT1R blockers as tentative treatment for SARS-CoV-2 infections, and proposes a research direction based on datamining of clinical patient records for assessing its feasibility. | 2020-03-04 |
| 32129583 | In heart failure group, the ratio of the expansion of small pulmonary veins was also higher (3/7 vs. 0, P=0.013), and the lung lesions can be significantly improved after effective anti-heart failure treatment. | 2020-03-04 |
| 32130038 | These patients were isolated and obtained treatment. | 2020-03-04 |
| 32131151 | From February 7 to 14, 2020, 246 medical staff were investigated who participated in the treatment of COVID-19 using cluster sampling , and received 230 responses, with a recovery rate of 93.5%. Results: The incidence of anxiety in medical staff was 23.04% (53/230), and the score of SAS was (42.91 ± 10.89). | 2020-03-04 |
| 32133830 | The median of the incubation period of customer cases was 6 days, and the median of the interval between onset and medical treatment of customer cases was 7 days. Conclusion: This was a cluster epidemic of COVID-19, which might be associated with the exposure in the department store. | 2020-03-05 |
| 32133833 | Considering the negative result of nuclear acid testing, this patient was presumptively diagnosed as viral pneumonia and an experiential anti-infection treatment had been prescribed for him. Conclusions: The 2019 novel coronavirus disease (COVID-19) complicates the clinical scenario of pulmonary infiltrates in cancer patients. […] Active anti-infection treatment and surveillance of patient condition should be initiated if infectious disease is considered. 目的： 结合化疗后出现肺内磨玻璃影的淋巴瘤患者的临床特征，分析当前新型冠状病毒肺炎（COVID-19）疫情期间肿瘤患者出现肺内浸润的鉴别诊断和临床处理思路。 | 2020-03-05 |
| 32134278 | Hence, the research advancements on SARS-CoV treatment might help scientific community in quick understanding of this virus pathogenesis and develop effective therapeutic/prophylactic agents to treat and prevent this infection. […] The therapeutic potential of monoclonal antibodies has been well recognized in the treatment of many diseases. | 2020-03-24 |
| 32134861 | Currently, there is no definite treatment for COVID-19 although some drugs are under investigation. | 2020-03-18 |
| 32141058 | Due to the current lack of specific treatment and the risk of transmission during the viral incubation period, infection prevention and control of 2019-nCoV are both urgent and critical to global health. | 2020-03-11 |
| 32141619 | The Chinese government has taken emergency measures to control the outbreak and has undertaken initial steps in the diagnosis and treatment of 2019 novel coronavirus infection disease (COVID-19). | 2020-03-12 |
| 32141624 | Isolation and protective procedures would be less effective as more cases accrue, so the optimization of the treatment plan and the development of specific drugs would be of more importance. […] Evidence from the four-phase stringent measures showed that it was significant to ensure early detection, early isolation, early treatment, adequate medical supplies, patients’ being admitted to designated hospitals, and comprehensive therapeutic strategy. | 2020-03-24 |
| 32142651 | A TMPRSS2 inhibitor approved for clinical use blocked entry and might constitute a treatment option. | 2020-04-01 |
| 32143502 | The future of human CoV outbreaks will not only depend on how the viruses will evolve, but will also depend on how we develop efficient prevention and treatment strategies to deal with this continuous threat. | 2020-03-09 |
| 32145185 | This Seminar provides an update on the current knowledge and perspectives on MERS epidemiology, virology, mode of transmission, pathogenesis, diagnosis, clinical features, management, infection control, development of new therapeutics and vaccines, and highlights unanswered questions and priorities for research, improved management, and prevention. | 2020-04-13 |
| 32145714 |
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2020-03-08 |
| 32145716 | Whatever happens, screening and isolating close contacts remains essential except for clinical treatment during the epidemic. | 2020-03-08 |
| 32145718 | The outbreak of coronavirus disease 2019 (COVID-19) has opened a public class on the treatment, prevention and control of infectious diseases for the Chinese citizens. […] In future, when combating with novel infectious diseases and public health emergencies, the response capacity of public health system and treatment capacity of clinical system will be significantly improved, while the situation on insufficient integration of prevention and treatment is bound to be reversed. | 2020-03-08 |
| 32147496 | Recent publications have brought attention to the possible benefit of chloroquine, a broadly used antimalarial drug, in the treatment of patients infected by the novel emerged coronavirus (SARS-CoV-2). | 2020-04-15 |
| 32147628 | Several drugs such as chloroquine, arbidol, remdesivir, and favipiravir are currently undergoing clinical studies to test their efficacy and safety in the treatment of coronavirus disease 2019 (COVID-19) in China; some promising results have been achieved thus far. | 2020-03-16 |
| 32149769 | Medicines for the treatment of 2019-novel coronavirus (2019-nCoV) infections are urgently needed. […] This study aims to repurpose the clinically approved drugs for the treatment of coronavirus disease 2019 (COVID-19) in a 2019-nCoV related coronavirus model. […] The viral RNA yield in cells treated with 10 μmol/L CEP was 15,393-fold lower than in cells without CEP treatment ([6.48 ± 0.02] × 10vs. […] Our results strongly suggest that CEP is a wide-spectrum inhibitor of pan-betacoronavirus, and clinical trial of CEP for treatment of 2019-nCoV infection is warranted. | 2020-03-09 |
| 32149773 | The effectiveness of adjunctive glucocorticoid therapy uses in the management of 2019-nCoV infected patients with severe lower respiratory tract infections is not clear, and warrants further investigation. | 2020-03-09 |
| 32152082 | Therapeutics that target the coronavirus alone might not be able to reverse highly pathogenic infections. | 2020-03-10 |
| 32152361 | We present several distinct features of MERS transmission by employing a comprehensive approach in network research to examine both the traced relationship matrix of infected individuals and their bipartite transmission routes among healthcare facilities visited for treatment. | 2020-03-19 |
| 32153167 | The National Health Commission, PRC has revised the consensus on diagnosis and treatment seven times in a short period of time, indicating the growing understanding of the disease. […] We were trying to find the similarities and differences among them, and to identify clues to the diagnosis of novel coronavirus pneumonia, so as to ensure accurate diagnosis and treatment. | 2020-03-10 |
| 32153170 | The liver function of all patients had recovered within one week after conventional liver protection treatment. Conclusion: COVID-19 combined with liver function injury may be due to the slight elevation of transaminase, mostly around the second week of the disease course. | 2020-03-10 |
| 32155789 | Specific up-to-date and accurate health information (e.g., treatment, local outbreak situation) and particular precautionary measures (e.g., hand hygiene, wearing a mask) were associated with a lower psychological impact of the outbreak and lower levels of stress, anxiety, and depression (p < 0.05). Conclusions: During the initial phase of the COVID-19 outbreak in China, more than half of the respondents rated the psychological impact as moderate-to-severe, and about one-third reported moderate-to-severe anxiety. | 2020-03-18 |
| 32156101 | Our newly developed protocol should be helpful for a first-hand screening of the asymptomatic virus-carriers for further prevention of transmission and early intervention and treatment for the rapidly propagating virus. | 2020-03-11 |
| 32156648 | Following the public-health emergency of international concern (PHEIC) declared by the World Health Organization (WHO) on 30 January 2020 and the recent outbreak caused by 2019 novel coronavirus (2019-nCoV) [officially renamed severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)] in China and 29 other countries, we aimed to summarise the clinical aspects of the novelBetacoronavirus disease (COVID-19) and its possible clinical presentations together with suggested therapeutic algorithms for patients who may require antimicrobial treatment. | 2020-04-06 |
| 32157264 | The KRD regimen was able to convert the chimerism after bone marrow transplant from partial to complete after the first 2 cycles of treatment, showing some activity in this disease. | 2020-03-12 |
| 32157732 | The use of mAb therapeutics has also revealed a “scaffolding” role for FcγR which, in different contexts, may either underpin the therapeutic mAb action such as immune agonism or trigger catastrophic adverse effects. | 2020-04-14 |
| 32157862 | In this case report, we aim to define the chest computed tomography findings of 2019-novel coronavirus associated with pneumonia and its successful resolution after treatment. […] Despite the given treatment, her body temperature rose to 39.2°C and she was referred to our clinic for further evaluation. | 2020-04-15 |
| 32161940 | Surveillance of NLR and lymphocyte subsets is helpful in the early screening of critical illness, diagnosis and treatment of COVID-19. | 2020-04-03 |
| 32162081 | Three of these five had CT abnormality on the first CT scan (at 2 days, 4 days and 9 days, respectively, after onset of symptoms) in the form of patchy ground-glass opacities; all normalised during treatment. | 2020-03-12 |
| 32162456 | The recently emerged 2019 Novel Coronavirus (SARS-CoV-2) and associated COVID-19 disease cause serious or even fatal respiratory tract infection and yet no approved therapeutics or effective treatment is currently available to effectively combat the outbreak. […] This urgent situation is pressing the world to respond with the development of novel vaccine or a small molecule therapeutics for SARS-CoV-2. | 2020-03-26 |
| 32162699 | However, there is no unified standard for the diagnosis and treatment of COVID-19. […] In the retrospective analysis, we report nine cases of COVID-19, describe the history of contact, clinical manifestations, the course of diagnosis and clinical treatment before, during and after treatment. | 2020-03-16 |
| 32164078 | Based on current studies, the author summarized the clinical characteristics and evolution of the novel viral pneumonia, and proposed the key points of diagnosis and treatment, the scientific management of both confirmed and suspected cases, and the scientific management of disease prevention and control. | 2020-03-13 |
| 32164081 | We here share the therapeutic experiences of NCP treatment with literature review. | 2020-03-13 |
| 32164085 | Here we found that treating the patients diagnosed as novel coronavirus pneumonia with chloroquine might improve the success rate of treatment, shorten hospital stay and improve patient outcome. […] In order to guide and regulate the use of chloroquine in patients with novel coronavirus pneumonia, the multicenter collaboration group of Department of Science and Technology of Guangdong Province and Health Commission of Guangdong Province for chloroquine in the treatment of novel coronavirus pneumonia developed this expert consensus after extensive discussion. | 2020-03-13 |
| 32164086 | Respiratory support is the most important therapy for SARI patients with respiratory failure. | 2020-03-13 |
| 32164092 | At present, there is no definite and effective treatment for COVID-19. | 2020-03-13 |
| 32164424 | Similar to outbreaks of other newly identified virus, there is no proven regimen from conventional medicine and most reports managed the patients with lopinavir/ritonavir, ribavirin, beta-interferon, glucocorticoid and supportive treatment with remdesivir undergoing clinical trial. […] In China, Chinese medicine is proposed as a treatment option by national and provincial guidelines with substantial utilization. […] We reviewed the latest national and provincial clinical guidelines, retrospective cohort studies, and case series regarding the treatment of COVID-19 by add-on Chinese medicine. | 2020-03-13 |
| 32166607 | Treatment is essentially supportive; role of antiviral agents is yet to be established. | 2020-03-23 |
| 32167153 | We thought that it is timely to explain the connection between the SARS-CoV, SARS-CoV-2, ACE2 and the rationale for soluble ACE2 as a potential therapy. | 2020-03-18 |
| 32167524 | Epidemiological, demographic, clinical, laboratory, management, treatment, and outcome data were also collected and analyzed. […] Among patients with ARDS, treatment with methylprednisolone decreased the risk of death (HR, 0.38; 95% CI, 0.20-0.72). […] Moreover, treatment with methylprednisolone may be beneficial for patients who develop ARDS. | 2020-03-17 |
| 32168162 | The patient showed improvement both clinically and on computed tomography imaging at discharged after 2 weeks’treatment. | 2020-04-16 |
| 32169119 | In this review, we summarized the latest research progress of the epidemiology, pathogenesis, and clinical characteristics of COVID-19, and discussed the current treatment and scientific advancements to combat the epidemic novel coronavirus. | 2020-03-19 |
| 32169481 | These nine residues can be used to develop therapeutics specific against COVID-19. | 2020-04-16 |
| 32170865 | The purpose of this review is primarily to review the pathogen, clinical features, diagnosis, and treatment of COVID-19, but also to comment briefly on the epidemiology and pathology based on the current evidence. | 2020-03-29 |
| 32171076 | Demographic, clinical, treatment, and laboratory data, including serial samples for viral RNA detection, were extracted from electronic medical records and compared between survivors and non-survivors. | 2020-04-03 |
| 32171740 | In the absence of a known efficient therapy and because of the situation of a public-health emergency, it made sense to investigate the possible effect of chloroquine/hydroxychloroquine against SARS-CoV-2 since this molecule was previously described as a potent inhibitor of most coronaviruses, including SARS-CoV-1. […] Preliminary trials of chloroquine repurposing in the treatment of COVID-19 in China have been encouraging, leading to several new trials. | 2020-04-04 |
| 32171866 | The Lopinavir and Ritonavir Tablets, Chinese medicine, oxygen therapy, and mechanical ventilation were statistically different in the elderly group and the young and middle-aged group, and the P values were all <0.05. | 2020-04-01 |
| 32171869 | Patients who were transferred to intensive care units (ICU) had significantly longer duration of fever as compared to those not in ICU (31 days v.s. 9 days after onset of symptoms, respectively, P <0.0001). […] The clinical progression pattern suggests that early control of viral replication and application of host-directed therapy in later stage is essential to improve the prognosis of CVOID-19. | 2020-04-16 |
| 32171872 | We aimed to compare arbidol and lopinavir/ritonavir(LPV/r) treatment for patients with COVID-19 with LPV/r only. | 2020-04-16 |
| 32172226 | Up to now, clinical features and treatment of patients infected with SARS-CoV-2 have been reported in detail. | 2020-04-01 |
| 32172228 | Overall, potential RT-PCR vulnerabilities include general preanalytical issues such as identification problems, inadequate procedures for collection, handling, transport and storage of the swabs, collection of inappropriate or inadequate material (for quality or volume), presence of interfering substances, manual errors, as well as specific aspects such as sample contamination and testing patients receiving antiretroviral therapy. | 2020-04-01 |
| 32172669 | To standardize the diagnosis and treatment of this new infectious disease, an operational recommendation for the diagnosis and management of SARS-CoV-2 infection is developed by Peking Union Medical College Hospital. | 2020-03-17 |
| 32173110 | As of this time, there is no known effective pharmaceutical treatment, although it is much needed for patient contracting the severe form of the disease. […] The aim of this systematic review was to summarize the evidence regarding chloroquine for the treatment of COVID-19. | 2020-03-16 |
| 32173241 | To date, effective treatment is lacking; however, clinical trials investigating the efficacy of several agents, including remdesivir and chloroquine, are underway in China. | 2020-04-09 |
| 32173576 | Levels of potassium, albumin, lymphocyte were low, but increased persistently after treatment. | 2020-03-16 |
| 32173725 | Refractory COVID-19 patients were more likely to receive oxygen, mechanical ventilation, expectorant, and adjunctive treatment including corticosteroid, antiviral drugs and immune enhancer (P<0.05). | 2020-03-16 |
| 32174096 | Objective: To explore the management strategies for patients with gynecological malignant tumors during the outbreak and transmission of COVID19. Methods: We retrospectively analyzed the clinical characteristics, treatment, and disease outcomes of three patients with gynecological malignancies associated with COVID19 in Renmin Hospital of Wuhan University in January 2020, and proposed management strategies for patients with gynecological tumors under risk of COVID19. Results: Three patients were treated COVID19 based on the national diagnosis and treatment protocol as well as research progress. […] Meanwhile, these patients were appropriately adjusted the treatment plan in accordance with the clinical guidelines for gynecological tumors. […] Pneumonia was cured in 2 patients, and one patient died of COVID-19. Conclusions: Patients with gynecological malignant tumors are high-risk groups prone to COVID-19 infection, and gynecological oncologists need to carry out education, prevention, control and treatment according to specific conditions. […] While actively preventing and controlling COVID-19, the diagnosis and treatment of gynecological malignant tumors should be carried out in an orderly and safe manner. 目的： 在新型冠状病毒肺炎(COVID-19)暴发和传播期间，探讨妇科恶性肿瘤患者的管理策略。 | 2020-03-16 |
| 32176772 | Most patients received antiviral therapy (66 [98.5%] of 67 patients) and antibiotic therapy (66 [98.5%] of 67 patients). […] Arbidol treatment showed tendency to improve the discharging rate and decrease the mortality rate. | 2020-03-16 |
| 32178593 | These findings accentuate the unique features of COVID-19 and assist in the development of new therapeutics. | 2020-03-19 |
| 32178769 | Intensive care units will then be at maximum capacity; up to 4000 hospital beds will be needed by mid-April, 2020. | 2020-04-16 |
| 32179150 | This activity is conserved against SARS-Cov-2, thus placing teicoplanin as a potential treatment for patients with this virus. | 2020-04-02 |
| 32179788 | Coronavirus, EBOV, ZIKV, IAV and measles), and also topically for the successful treatment of active lesions (e.g. | 2020-03-24 |
| 32179908 | We report a 55-day-old case with COVID-19 confirmed in China and describe the identification, diagnosis, clinical course, and treatment of the patient, including the disease progression from day 7 to day 11 of illness. | 2020-03-17 |
| 32180140 | We should attach importance to early recognition, early diagnosis, and early treatment of infected children. | 2020-03-17 |
| 32180175 | Three of the parturients are still recovering from their Cesarean delivery and are receiving in-hospital treatment for COVID-19. | 2020-04-03 |
| 32181903 | In severe novel coronavirus pneumonia cases, the number of platelets, their dynamic changes during the treatment, platelet-to-lymphocyte ratio (PLR) were a concern. […] Demographic, clinical, blood routine results, other laboratory results, and treatment data were collected and analyzed. […] Univariate analysis showed that: age, platelet peaks, and PLR at peak platelet were the influencing factors in severe patients, multivariate analysis showed that the PLR value at peak platelet during treatment was an independent influencing factor in severe patients. […] The average hospitalization day of patients with platelet peaks during treatment was longer than those without platelet peaks (P < .05). […] The average age of patients with platelet peaks during treatment was older than those without platelet peaks (P < .05). […] The patients with significantly elevated platelets during treatment had longer average hospitalization days. […] And the higher PLR of patients during treatment had longer average hospitalization days. […] Single-center case series of the 30 hospitalized patients with confirmed COVID-19 in Huizhou Municipal Central Hospital, presumed that the number of platelets and their dynamic changes during the treatment may have a suggestion on the severity and prognosis of the disease. | 2020-03-28 |
| 32181990 | Following a treatment regimen consisting of reduced immunosuppressant use and low dose methylprednisolone-based therapy, the COVID-19 pneumonia in this long-term immunosuppressive patient was successfully recovered. […] This effectively treated case has reference value for the future treatment of other transplant patients with COVID-19 pneumonia. | 2020-04-01 |
| 32183901 | To date, no specific antiviral treatment has proven effective; hence, infected people primarily rely on symptomatic treatment and supportive care. | 2020-03-19 |
| 32185921 | If the diagnosis and treatment of malaria cases as well as the investigation and response of the epidemic foci are not carried out timely, it may endanger patients’lives and cause the possible of secondary transmission, which threatens the achievements of malaria elimination in China. […] Due to the extensive spread and high transmission ability of the COVID-19, there is a possibility of virus infections among malaria cases during the medical care-seeking behaviors and among healthcare professionals during clinical diagnosis and treatment, sample collection and testing and epidemiological surveys. | 2020-03-19 |
| 32186172 | Close monitoring of oxygenation, reducing patients’ oxygen consumption, active psychological intervention, and rapidly dealing with severe hypoxemia events are the key factors for the successful treatment of NIV. […] In addition, active adjuvant therapy is also important, such as correcting coagulation dysfunction, providing proper nutritional support, accurate volume control, and safe individualized blood glucose monitoring and control. | 2020-03-18 |
| 32186277 | Based on the experience from Italy, countries, hospitals and intensive care units should increase their preparedness for a surge of patients with COVID-19 who will require healthcare, and in particular intensive care. | 2020-04-02 |
| 32186894 | OBJECTIVE. The purpose of this study was to describe the clinical manifestations and CT features of coronavirus disease (COVID-19) pneumonia in 15 pregnant women and to provide some initial evidence that can be used for guiding treatment of pregnant women with COVID-19 pneumonia. MATERIALS AND METHODS. We reviewed the clinical data and CT examinations of 15 consecutive pregnant women with COVID-19 pneumonia in our hospital from January 20, 2020, to February 10, 2020. […] Symptoms and laboratory results were analyzed, treatment experiences were summarized, and clinical outcomes were tracked. RESULTS. Eleven patients had successful delivery (10 cesarean deliveries and one vaginal delivery) during the study period, and four patients were still pregnant (three in the second trimester and one in the third trimester) at the end of the study period. | 2020-03-18 |
| 32186952 | However, to date, no licensed antiviral treatment or vaccine exists for MERS and SARS. […] This article highlights ongoing advances in designing vaccines and therapeutics to counter COVID-19 while also focusing on such experiences and advances as made with earlier SARS- and MERS-CoVs, which together could enable efforts to halt this emerging virus infection. | 2020-04-01 |
| 32187464 | No therapeutics have yet been proven effective for the treatment of severe illness caused by SARS-CoV-2. […] Treatment with lopinavir-ritonavir was not associated with a difference from standard care in the time to clinical improvement (hazard ratio for clinical improvement, 1.24; 95% confidence interval [CI], 0.90 to 1.72). […] Lopinavir-ritonavir treatment was stopped early in 13 patients (13.8%) because of adverse events. […] In hospitalized adult patients with severe Covid-19, no benefit was observed with lopinavir-ritonavir treatment beyond standard care. […] Future trials in patients with severe illness may help to confirm or exclude the possibility of a treatment benefit. | 2020-04-12 |
| 32187887 | From the perspective of clinical pediatricians as the first line fighting the epidemic, this paper will discuss the clinical characteristics, prevention and control measures, outcomes, diagnosis, and treatment of pediatric cases. | 2020-04-16 |
| 32187929 | The outbreak of pneumonia caused by the novel coronavirus (2019-nCoV) in Wuhan, Hubei province of China, at the end of 2019 shaped tremendous challenges to China’s public health and clinical treatment. | 2020-03-19 |
| 32189175 | Knowledge of CT characteristics of COVID-19 pneumonia might be helpful to the early diagnosis and treatment of patients, and to control the spread of infection. | 2020-03-19 |
| 32190290 | Here we highlight nine most important research questions concerning virus transmission, asymptomatic and presymptomatic virus shedding, diagnosis, treatment, vaccine development, origin of virus and viral pathogenesis. | 2020-03-22 |
| 32190904 | Here we reported the screening, clinical feathers, and treatment process of a family cluster involving three COVID-19 patients. | 2020-03-19 |
| 32191691 | Singapore adopted a multipronged surveillance strategy that included applying the case definition at medical consults, tracing contacts of patients with laboratory-confirmed COVID-19, enhancing surveillance among different patient groups (all patients with pneumonia, hospitalized patients in intensive care units [ICUs] with possible infectious diseases, primary care patients with influenza-like illness, and deaths from possible infectious etiologies), and allowing clinician discretion (i.e., option to order a test based on clinical suspicion, even if the case definition was not met) to identify COVID-19 patients. | 2020-03-20 |
| 32191830 | Severe forms of the infection, being an indication for treatment in the intensive care unit, comprise acute lung inflammation, ARDS, sepsis and septic shock. […] The article presents basic information about etiology, pathogenesis and diagnostics (with particular emphasis on the importance of tomocomputer imaging), clinical picture, treatment and prevention of the infection. […] Due to the fact that effective causal treatment is not yet available and the number of infections and deaths increases day by day, infection prevention and strict adherence to recommendations of infection control organizations remain the basis for fighting the virus. | 2020-03-26 |
| 32192278 | These measures for early detection and screening of cases should be followed by full efforts to produce research-based evidence by thoroughly analyzing epidemiological, clinical and immunological data, which will facilitate the development of vaccines and therapeutics for COVID-19. | 2020-04-08 |
| 32192294 | By summarizing the research progress and guidelines in recent years in the fields of colorectal cancer disease screening, treatment strategies (including early colorectal cancer, locally advanced colorectal cancer, obstructive colorectal cancer, metastatic colorectal cancer and the treatment of patients after neoadjuvant therapy), the choice of medication and time limit for adjuvant therapy, the protective measures for patients undergoing emergency surgery, the re-examination of postoperative patients and the protection of medical staff, etc., authors improve treatment strategies in order to provide more choices for patients to obtain the best treatment under the severe epidemic situation of new coronavirus pneumonia. […] Meanwhile we hope that it can also provide more timely treatment modeling schemes for colleagues. | 2020-03-23 |
| 32192296 | Although colorectal surgery is not a front-line subject in the fight against the epidemic, but in this special situation, it is a difficult task to provide the highest quality medical services and ensure the orderly clinical work, on the premise of maximizing the protection for patients and their families, health of medical staff, and the safety of wards and hospitals, We summarize how to carry out the clinical practice of colorectal surgery under the situation of the prevention and control of the COVID-19 epidemiology, including the procedures of diagnose and treatment for emergency patients with colorectal tumor, and share the experiences of the diagnosis of colorectal tumor, the management of patients with colorectal cancer who are scheduled to be admitted for surgery, the protection of wards, the perioperative management. […] The main points are as follows: (1) Multidisciplinary team (MDT) must be run through the diagnosis and treatment of colorectal cancer. | 2020-03-23 |
| 32192297 | The outbreak of corona virus disease 2019 (COVID-19) makes the medical treatment of colorectal cancers difficult. […] For metastatic colorectal cancer (CRC) patients, maintenance therapy is the optimal choice. […] Adjuvant chemotherapy should reduce the intensity of treatment and shorten the therapy time. | 2020-03-23 |
| 32193037 | We analyzed the initial and follow-up CT features of patients with disease severity, according to the Guidelines for the Diagnosis and Treatment of New Coronavirus Pneumonia. | 2020-04-10 |
| 32193831 | Treatment modalities were focused on symptomatic and respiratory support. […] Up to February 24, 2020, three patients remained under treatment in ICU, the other five recovered and were discharged home. | 2020-03-20 |
| 32193905 | In this report, we present mild clinical course of her pneumonia that did not require antiviral treatment and serial viral test results from multiple specimens. | 2020-03-23 |
| 32194034 | It is more infectious and fatal than seasonal influenza, and definitive treatment and a vaccine are months away. | 2020-04-14 |
| 32194944 | Among these, the antivirals ledipasvir or velpatasvir are particularly attractive as therapeutics to combat the new coronavirus with minimal side effects, commonly fatigue and headache. | 2020-03-24 |
| 32195698 | Here, the authors review COVID-19 pathogenesis, presentation, diagnosis, and potential therapeutics, with a focus on management of COVID-19-associated respiratory failure. […] The authors draw on literature from other viral epidemics, treatment of acute respiratory distress syndrome, and recent publications on COVID-19, as well as guidelines from major health organizations. | 2020-04-16 |
| 32195704 | So far, actions have been taken including but not limited to nationwide actions and online education regarding special procedures of airway management, oxygen therapy, ventilation support, hemodynamic management, sedation, and analgesia. | 2020-04-16 |
| 32195705 | Timely, but not premature, intubation is crucial to counter a progressively enlarging oxygen debt despite high-flow oxygen therapy and bilevel positive airway pressure ventilation. | 2020-04-16 |
| 32196032 | Identifying antibodies (Abs) that neutralize infectious agents is the first step for developing therapeutics, vaccines, and diagnostic tools for these infectious agents. | 2020-03-20 |
| 32196083 | There is an urgent need to identify safe and effective drugs for treatment. | 2020-03-20 |
| 32196410 | Combined with the published literature, the potential pathogenesis of COVID-19 is inferred, and the treatment recommendations for giving high-doses intravenous immunoglobulin and low-molecular-weight heparin anticoagulant therapy to severe type patients are proposed. | 2020-04-07 |
| 32196707 | All patients were given antiviral therapy (including oseltamivir), oxygen inhalation, and antibiotics. […] One of the five patients had transient hemostatic medication for hemoptysis. | 2020-03-31 |
| 32197238 | This Special Feature highlights the unique circumstances and challenges of cancer treatment amidst this global pandemic, and the importance of organizational structure, preparation, agility, and a shared vision for continuing to provide cancer treatment to patients in the face of uncertainty and rapid change. | 2020-04-10 |
| 32197787 | There is not specific treatment for SARS-CoV-2, which is why the fundamental aspects are to establish adequate prevention measures and support treatment and management of complications. | 2020-04-01 |
| 32198776 | Epidemiological, clinical features, laboratory findings, radiological characteristics, treatment, and clinical outcomes of 135 patients in northeast Chongqing were collected and analyzed in this study. […] All patients received antiviral therapy (135 [100%]) (Kaletra and interferon were both used), antibacterial therapy (59 [43.7%]), and corticosteroids (36 [26.7%]). […] Kaletra and TCM played an important role in the treatment of the viral pneumonia. […] Further studies are required to explore the role of Kaletra and TCM in the treatment of COVID-19. | 2020-04-02 |
| 32201353 | Based on the current published evidence, we systematically summarizes the epidemiology, clinical characteristics, diagnosis, treatment and prevention of knowledge surrounding COVID-19. | 2020-04-16 |
| 32202256 | Hospitalized adult patients with laboratory-confirmed SARS-CoV-2 infection with any one of the following criteria will be eligible to receive lopinavir/ritonavir for 14 days after obtaining written informed consent: (i) respiratory distress with respiratory rate ≥22/min or SpO2 of <94 per cent; (ii) lung parenchymal infiltrates on chest X-ray; (iii) hypotension defined as systolic blood pressure <90 mmHg or need for vasopressor/inotropic medication; (iv) new-onset organ dysfunction; and (v) high-risk groups - age >60 yr, diabetes mellitus, renal failure, chronic lung disease and immunocompromised persons. […] Treatment outcomes amongst initial cases would be useful in providing guidance about the clinical management of patients with COVID-19. | 2020-03-23 |
| 32202343 | Suggested treatment included providing oxygen, inhalations, nutritional support and maintaining fluids and electrolyte balances. | 2020-04-14 |
| 32202646 | Frontline health care workers engaged in direct diagnosis, treatment, and care of patients with COVID-19 were associated with a higher risk of symptoms of depression (OR, 1.52; 95% CI, 1.11-2.09; P = .01), anxiety (OR, 1.57; 95% CI, 1.22-2.02; P < .001), insomnia (OR, 2.97; 95% CI, 1.92-4.60; P < .001), and distress (OR, 1.60; 95% CI, 1.25-2.04; P < .001). […] In this survey of heath care workers in hospitals equipped with fever clinics or wards for patients with COVID-19 in Wuhan and other regions in China, participants reported experiencing psychological burden, especially nurses, women, those in Wuhan, and frontline health care workers directly engaged in the diagnosis, treatment, and care for patients with COVID-19. | 2020-04-01 |
| 32203189 | The outbreak of Coronavirus Disease 2019 (COVID-19) has posed a serious threat to global public health, calling for the development of safe and effective prophylactics and therapeutics against infection of its causative agent, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), also known as 2019 novel coronavirus (2019-nCoV). | 2020-03-26 |
| 32203711 | Available evidence from similar patient populations suggests that carefully selected patients with severe ARDS who do not benefit from conventional treatment might be successfully supported with venovenous ECMO. | 2020-04-01 |
| 32204411 | It may provide references for policy makers to plan and fight against COVID-19 effectively by improving stability of popular feelings and urgently prepare clinical practitioners to deliver corresponding therapy foundations for the risk groups and affected people. | 2020-04-01 |
| 32204750 | With the spread of coronavirus disease 2019 (COVID-19) and growing knowledge of its diagnosis and treatment, it has been clear that children are also susceptible to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). | 2020-03-26 |
| 32204751 | At present there is limited clinical information of the SARS-CoV-2 and there is no specific treatment recommended, although technical guidances and suggestions have been developed and will continue to be updated as additional information becomes available. […] Preventive treatment has an important role to control and avoid the spread of severe respiratory disease, but often is difficult to obtain and sometimes cannot be effective to reduce the risk of deterioration of the underlining lung pathology. […] In order to define an effective and safe treatment for SARS-CoV-2-associated disease, we provide considerations on the actual treatments, on how to avoid complications and the undesirable side effects related to them and to select and apply earlier the most appropriate treatment. […] The final outcome is strictly connected with the ability to apply an appropriate treatment early and to reduce all the complications that can arise during the intensive care admission. | 2020-03-26 |
| 32204755 | After two weeks of treatment, the patient recovered gradually and was discharged. | 2020-03-26 |
| 32204757 | This article reports the diagnosis and treatment of twin girls who were diagnosed with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in Hunan Province, China. […] Both recovered after symptomatic treatment. | 2020-03-26 |
| 32204758 | Newborns with suspected or confirmed COVID-19 should be transferred to designated hospitals for isolation treatment. | 2020-03-26 |
| 32205092 | Development of effective prevention and treatment is an urgent need. | 2020-04-16 |
| 32205186 | Given the lack of specific anti-viral therapies, the current management of severe acute respiratory syndrome coronaviruses (SARS-CoV-2) is mainly supportive, even though several compounds are now under investigation for the treatment of this life-threatening disease. […] COVID-19 pandemic is certainly conditioning the treatment strategy of a complex disorder as rheumatoid arthritis (RA), whose infectious risk is increased compared to the general population because of an overall impairment of immune system typical of autoimmune diseases combined with the iatrogenic effect generated by corticosteroids and immunosuppressive drugs. […] However, the increasing knowledge about the pathophysiology of SARS-CoV-2 infection is leading to consider some anti-rheumatic drugs as potential treatment options for the management of COVID-19. | 2020-04-01 |
| 32205204 | Depending on their clinical presentation, azithromycin was added to the treatment. […] Despite its small sample size our survey shows that hydroxychloroquine treatment is significantly associated with viral load reduction/disappearance in COVID-19 patients and its effect is reinforced by azithromycin. | 2020-04-01 |
| 32205232 | Furthermore, LH treatment resulted in abnormal particle morphology of virion in cells. | 2020-04-01 |
| 32205349 | Scientists are racing towards the development of treatment for COVID-19. | 2020-03-24 |
| 32207032 | However, children less than 3 years old accounted for majority cases and critical cases lied in this age group, which demanded extra attentions during home caring and hospitalization treatment. | 2020-03-24 |
| 32207377 | Due to its high pathogenicity and infectivity and the lack of effective vaccines and therapeutics, live SARS-CoV-2 has to be handled under biosafety level 3 conditions, which has hindered the development of vaccines and therapeutics. […] When tested against the SARS-CoV-2 pseudovirus, SARS-CoV-2 convalescent patient sera showed high neutralizing potency, which underscore its potential as therapeutics. […] Taken together, we established a robust pseudovirus-based neutralization assay for SARS-CoV-2 and are glad to share pseudoviruses and related protocols with the developers of vaccines or therapeutics to fight against this lethal virus. | 2020-03-26 |
| 32207591 | A total of 67 patients diagnosed as COVID-19 by nucleic acid testing were included and divided into 4 groups according to the clinical staging based on Diagnosis and treatment of novel coronavirus pneumonia (Trial version 6). | 2020-03-26 |
| 32208494 | Due to the current development around the COVID-19 pandemic, palliative ch has created a Task Force to provide recommendations for health professionals on the treatment of palliative care patients in the various settings ‒ inpatient and outpatient. | 2020-04-02 |
| 32208840 | Furthermore, he observes the significant abnormality of coagulation function and proposes that the early intravenous immunoglobulin and low molecular weight heparin anticoagulation therapy are very important. […] For severe or critically ill patients, in addition to the respiratory supportive treatment, timely multiorgan evaluation and treatment is very crucial. | 2020-04-07 |
| 32208987 | Because the ACE2 (angiotensin-converting enzyme 2) protein is the receptor that facilitates coronavirus entry into cells, the notion has been popularized that treatment with renin-angiotensin system blockers might increase the risk of developing a severe and fatal severe acute respiratory syndrome coronavirus-2 infection. […] In summary, based on the currently available evidence, treatment with renin-angiotensin system blockers should not be discontinued because of concerns with coronavirus infection. | 2020-03-26 |
| 32209890 | C-reactive protein (CRP) levels were also significantly higher in the death group on admission (109.25 [35.00, 170.28] mg/L vs.3.22 [1.04, 21.80] mg/L, Z = 10.206, P < 0.001) showed no significant improvement after treatment (109.25 [35.0, 170.28] mg/L vs. | 2020-03-26 |
| 32210741 | Altogether, the results presented in this work contribute to gain a deep understanding of the molecular pharmacology of SARS-CoV-2 treatment and validate the use of protease inhibitors against SARS-CoV-2. | 2020-03-28 |
| 32211816 | Clinical laboratory, radiological, and treatment data were collected and analyzed. | 2020-03-28 |
| 32211844 | Epidemiological, clinical and treatment data were analyzed between those older (≥60y) and younger (<60y) patients. | 2020-03-26 |
| 32211963 | We retrospectively reviewed the initial chest CT data of 62 confirmed coronavirus disease 2019 patients (34 men, 28 women; age range 20-91 years old) who did not receive any antiviral treatment between January 21 and February 4, 2020, in Chongqing, China. | 2020-03-30 |
| 32212378 | This commentary seeks to share some key insights relevant to optimizing COVID-19 candidate therapeutics that were learned from attempts to optimize anti-infective posology in settings where quality and timely availability of data is challenging, with particular focus on influenza, including experiences from H5N1 and pH1N1 outbreaks. | 2020-03-26 |
| 32212779 | Cancer patients are more susceptible to coronavirus infection than individuals without cancer as they are in an immunosuppressive state because of the malignancy and anticancer treatment. | 2020-04-02 |
| 32213260 | Available animal and cell line models have suggested that specific therapeutics might be effective in treating Middle East respiratory syndrome (MERS). […] We conducted a systematic review of evidence for treatment with pharmacologic and supportive therapies. […] We developed a protocol and searched 5 databases for studies describing treatment of MERS and deaths in MERS patients. […] One study, at moderate RoB, showed reduced mortality rates in severe MERS patients with extracorporeal membrane oxygenation; no other studies showed a significant lifesaving benefit to any treatment. […] Clinical trials are needed to guide treatment decisions. | 2020-03-27 |
| 32213700 | The COVID-19 virus is severely testing the Italian healthcare system, as the requests for intensive treatment are greater than the real capacity of the system to receive patients. | 2020-04-02 |
| 32214286 | The World Health Organization (WHO) and multiple agencies led by the CDC in the United States have attempted to organize intensive outbreak investigation programs utilizing appropriate preventive measures, evaluation, and treatment. […] These include vaccines, medications Remdesivir and hydroxychloroquine and potentially combination therapy. […] Thus, at this point, the avoidance of the cytokine storm may be the key for the treatment of HCOV-19 infected patients.In China, where there was limited availability of effective modalities to manage COVID-19 several patients were treated with expanded UC-MSCs. […] In this manuscript, we describe the urgent need for various solutions, pathogenesis of coronavirus and the clinical evidence for treatment of COVID-19 with stem cells. | 2020-04-01 |
| 32215622 | Besides satisfying the Koch’s postulates, this readily available hamster model is an important tool for studying transmission, pathogenesis, treatment, and vaccination against SARS-CoV-2. | 2020-03-27 |
| 32216114 | These results provide a foundation for understanding the molecular basis of coronaviral PLPs’ catalytic mechanism and for the screening and design of therapeutics to combat infection by SADS coronavirus. | 2020-04-06 |
| 32216248 | Additionally, they constitute a closed conglomerate since they come to treatment regularly, spending hours in the treatment places, exposed to a possible acquisition of the infection. […] Finally, going to their treatment regularly prevents them from remaining in home isolation and with potential exposure. | 2020-03-27 |
| 32216653 | Outbreaks of infectious etiology, particularly those caused by a novel virus that has no known treatment or vaccine, may result in the interruption of medical care provided to patients with cancer and put them at risk for undertreatment in addition to the risk of being exposed to infection, a life-threatening event among patients with cancer. […] This article describes the approach used to manage patients with cancer during a large-scale Middle East respiratory syndrome-coronavirus hospital outbreak in Saudi Arabia to ensure continuity of care and minimize harm from treatment interruption or acquiring infection. | 2020-04-08 |
| 32217113 | We discuss the latest options in antiviral therapy and vaccine development, including the novel use of chloroquine in the management of COVID-19. | 2020-03-28 |
| 32217834 | Overall, this study characterized the cytokine storm in severe COVID-19 and provides insights into immune therapeutics and vaccine design. | 2020-04-13 |
| 32218301 | The herein-investigated benzimidazole-based derivatives may represent valuable hit compounds, deserving subsequent structural improvements towards more efficient antiviral agents for the treatment of pathologies caused by these human respiratory viruses. | 2020-03-30 |
| 32218340 | At the present, there is no single specific vaccine or efficient antiviral therapy against COVID-19. […] Recently, we showed that intravenous immunoglobulin (IVIg) treatment reduces inflammation of intestinal epithelial cells and eliminates overgrowth of the opportunistic human fungal pathogen Candida albicans in the murine gut. […] Different procedures may be used to remove or inactivate any possible pathogens from the plasma of recovered coronavirus patient derived immune IgG, including solvent/detergent, 60 °C heat-treatment, and nanofiltration. […] Overall, immunotherapy with immune IgG antibodies combined with antiviral drugs may be an alternative treatment against COVID-19 until stronger options such as vaccines are available. | 2020-04-07 |
| 32219356 | During hospitalization, patients with elevated TnT levels had more frequent malignant arrhythmias, and the use of glucocorticoid therapy (37 [71.2%] vs 69 [51.1%]) and mechanical ventilation (41 [59.6%] vs 14 [10.4%]) were higher compared with patients with normal TnT levels. […] Aggressive treatment may be considered for patients at high risk of myocardial injury. | 2020-03-31 |
| 32219357 | She was treated with dobutamine, antiviral drugs (lopinavir/ritonavir), steroids, chloroquine, and medical treatment for heart failure, with progressive clinical and instrumental stabilization. | 2020-03-28 |
| 32219428 | To determine whether convalescent plasma transfusion may be beneficial in the treatment of critically ill patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. […] Case series of 5 critically ill patients with laboratory-confirmed COVID-19 and acute respiratory distress syndrome (ARDS) who met the following criteria: severe pneumonia with rapid progression and continuously high viral load despite antiviral treatment; Pao2/Fio2 <300; and mechanical ventilation. […] All 5 patients (age range, 36-65 years; 2 women) were receiving mechanical ventilation at the time of treatment and all had received antiviral agents and methylprednisolone. […] ARDS resolved in 4 patients at 12 days after transfusion, and 3 patients were weaned from mechanical ventilation within 2 weeks of treatment. […] The limited sample size and study design preclude a definitive statement about the potential effectiveness of this treatment, and these observations require evaluation in clinical trials. | 2020-03-31 |
| 32219626 | Based on the New Diagnosis and Treatment Scheme for Novel Coronavirus Infected Pneumonia (Trial Edition 5), combined with our current clinical treatment experience, we recently proposed a revision of the first edition of “Guidance for maternal and fetal management during pneumonia epidemics of novel coronavirus infection in the Wuhan Tongji Hospital”. […] This article focused on the issues of greatest concern of pregnant women including severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection diagnostic criteria, inspection precautions, drug treatment options, indications and methods of termination of pregnancy, postpartum fever, breastfeeding considerations, mode of mother-to-child transmission, neonatal isolation and advice on neonatal nursing, to provide valuable experience for better management of SARS-CoV-2 infection in pregnant women and newborns. | 2020-03-28 |
| 32219627 | Based on the treatment of severe patients in Wuhan, combined with the treatment practice in Tongji Hospital affiliated to Tongji Medical College, Huazhong University of Science and Technology, this paper puts forward the urgency of further strengthening the construction of public hospitals, discusses the feasible path for promoting the development of public hospitals, so as to meet the growing medical needs of the people, improve the ability to respond to major public health emergencies, and effectively guarantee the safety of people’s lives and the promotion of a healthy China construction. | 2020-03-28 |
| 32219814 | In view of the seriousness of the COVID-19 epidemic, a series of prevention and control measures adopted by the government have restricted the follow-up, diagnosis and treatment of patients by the hospitals, which has a great impact on their mental and physical health. | 2020-04-02 |
| 32219882 | In the absence of specific treatment for this virus, there is an urgent need to learn from the experience and lessons in China. […] To help understand the advantages and limitations of differential treatments, we provide a timely review and discuss the complications and corresponding major treatments, especially controversial ones such as antiviral therapy (remdesivir, ribavirin, and chloroquine), glucocorticoid therapy, extracorporeal support including an artificial liver system, and extracorporeal membrane oxygenation based on available evidence. […] As a result, we suggest that antiviral therapy and organ function support are vital to reduce mortality for mild patients and critical patients, respectively. | 2020-04-10 |
| 32219885 | We also found that the RT-PCR results from several tests at different points were variable from the same patients during the course of diagnosis and treatment of these patients. […] Our results indicate that in addition to the emphasis on RT-PCR testing, clinical indicators such as computed tomography images should also be used not only for diagnosis and treatment but also for isolation, recovery/discharge, and transferring for hospitalized patients clinically diagnosed with COVID-19 during the current epidemic. | 2020-04-05 |
| 32219995 | Efficient obstetric treatment is required, and is key to optimizing the prognosis for both mother and child. | 2020-03-28 |
| 32220033 | Patients in the mild group experienced earlier initiation of antiviral treatment (1.19 ± 0.45 vs 2.65 ± 1.06 days in the severe group, P < 0.001). […] It is recommended that timely antiviral treatment should be initiated to slow the disease progression and improve the prognosis. | 2020-03-28 |
| 32220112 | Anticoagulant therapy mainly with LMWH appears to be associated with better prognosis in severe COVID-19 patients meeting SIC criteria or with markedly elevated D-dimer. | 2020-03-28 |
| 32220177 | This review summarizes the ongoing researches regarding etiology, epidemiology, transmission dynamics, treatment, and prevention and control strategies of the coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), with comparison to severe acute respiratory syndrome coronavirus (SARS-CoV), Middle East respiratory syndrome coronavirus (MERS-CoV) and pandemic H1N1 virus. […] Meanwhile, rapid detection kit for serological monitoring of the virus in general population is expected so as to achieve early detection, early diagnosis, early isolation and early treatment. | 2020-04-02 |
| 32220178 | As biological products have broadly applied in the prevention and treatment of severe epidemic diseases, they are promising in blocking novel coronavirus infection. […] According to the research advances of severe acute respiratory syndrome (SARS) and Middle East respiratory syndrome (MERS), we reviewed the potential application of biological products such as interferon, convalescent plasma, intestinal micro-ecological regulators, vaccines and therapeutic antibodies, etc. , on prevention and treatment of COVID-19. | 2020-04-02 |
| 32220179 | Based on the higher mortality and the higher proportion of critically ill adults in coronavirus disease 2019 (COVID-19) patients with diabetes, good inpatient glycemic control is particularly important in the comprehensive treatment of COVID-19. […] Individualized blood glucose target goals and treatment strategies should be made according to specific circumstances of COVID-19 inpatients with diabetes. […] For mild patients, a strict glycemic control target (fasting plasma glucose (FPG) 4.4-6.1 mmol/L, 2-hour postprandial plasma glucose (2 h PG) 6.1-7.8 mmol/L) are recommended; a target for the glycemic control of common type patients (FPG 6.1-7.8 mmol/L, 2 h PG 7.8-10.0 mmol/L) and subcutaneous insulin deliver therapy are recommended; a target nonfasting blood glucose range of 10.0 mmol or less per liter for severe-type COVID-19 patients, a relatively Less stringent blood glucose control target (FPG 7.8-10.0 mmol/L, 2 h PG 7.8-13.9 mmol/L) for critically ill patients and intravenous insulin infusion therapy are recommended. […] Due to the rapid changes in the condition of some patients, the risk of diabetic ketoacidosis (DKA) or hyperglycemic hyperosmolar status (HHS) maybe occur during the treatment. | 2020-04-02 |
| 32220276 | D-dimer and FDP levels increased progressively when COVID-2019 exacerbated, and 4 patients were diagnosed with definite disseminated intravascular coagulation (DIC). 6 patients received low molecular weight heparin (LMWH) treatment, after which their D-dimer and FDP decreased, but there was no significant improvement in clinical symptoms. 5 patients died finally and the median time from acro-ischemia to death was 12 days. Conclusions: The existence of hypercoagulation status in critical COVID-2019 patients should be monitored closely, and anticoagulation therapy can be considered in selected patients. […] More clinical data is needed to investigate the role of anticoagulation in COVID-2019 treatment. 目的： 总结合并肢端缺血的新型冠状病毒肺炎（COVID-19）患者的临床和凝血参数特征。 | 2020-03-29 |
| 32221523 | The widely used reverse transcription PCR (RT-PCR) method has limitations for clinical diagnosis and treatment. | 2020-03-29 |
| 32221973 | In particular, we describe key elements of clinical management, including: safe oxygen therapy; airway management; personal protective equipment; and non-technical aspects of caring for patients diagnosed with coronavirus disease 2019. | 2020-04-01 |
| 32221983 | Because of these protective effects of ACE2 on chronic underlying diseases and ARDS, the development of spike protein-based vaccine and drugs enhancing ACE2 activity may become one of the most promising approaches for the treatment of COVID-19 in the future. | 2020-04-05 |
| 32222119 | The aim is to evaluate pregnant women infected with coronavirus disease 2019 (COVID-19) and provide help for clinical prevention and treatment. | 2020-04-10 |
| 32222121 | To explore the feasibility of surgical treatment for cancer patients complicated with corona virus disease 2019 (COVID-19). […] The inflammation indicators and fever of this patient were effectively controlled and the lung lesions remained stable after active anti-viral treatment, then the radical colorectomy was performed after the viral negative conversion for twice. | 2020-04-01 |
| 32222466 | Here, from the perspective of clinical immunologists, we will discuss the clinical and immunological characteristics of severe patients, and summarize the current evidence and share our experience in anti-inflammation treatment, including glucocorticoids, IL-6 antagonist, JAK inhibitors and choloroquine/hydrocholoroquine, of patients with severe COVID-19 that may have an impaired immune system. | 2020-04-16 |
| 32222703 | COVID-19 patients with ESKD need isolation dialysis, but most of them cannot be handled in time due to limited continuous renal replacement therapy (CRRT) machines. | 2020-03-30 |
| 32222720 | Practical work experience in our spinal outpatient and emergency department during the COVID-19 pandemic is summarized in this article, with combined evidence-based medical evidence to explore a standardized process of diagnosis and treatment for spinal diseases. […] Spine surgeons should collaborate with infection control specialists to avoid cross-infection in hospitals and optimize treatment. | 2020-04-07 |
| 32222812 | The topics were: (1) infection control, (2) laboratory diagnosis and specimens, (3) hemodynamic support, (4) ventilatory support, and (5) COVID-19 therapy. | 2020-04-02 |
| 32222992 | All of these three cases experienced mild illness and recovered soon after the treatment, with the nucleic acid of throat swab turning negative within 14, 11, and 7 days after diagnosis, respectively. | 2020-04-15 |
| 32223003 | This also applies to AD patients on systemic immune-modulating treatment. […] In these days of uncertainty, reallocation of medical resources, curfew, hoarding, and shutdown of normal social life, patients, caregivers and doctors ask questions regarding the continuation of systemic immune-modulating treatment of AD patients. | 2020-03-30 |
| 32223012 | We compared clinical features between patients not requiring admission for clinical reasons or antimicrobials with those assessed as needing either admission or antimicrobial treatment. | 2020-04-08 |
| 32223665 | OBJECTIVE. This study aims to assess correlations of the time from symptom onset to diagnosis and treatment with the time to disease resolution and CT scores as based on findings from sequential chest CT examinations. MATERIALS AND METHODS. Thirty patients with coronavirus disease (COVID-19) confirmed by reverse transcription-polymerase chain reaction analysis underwent chest CT examinations. […] The time from symptom onset to diagnosis and treatment was recorded for each patient, and on the basis of this information, patients with COVID-19 were divided into group 1 (patients for whom this interval was ≤ 3 days) and group 2 (those for whom this interval was > 3 days). […] The CT scores for each group were fitted using a Lorentzian line-shape curve to show the variation tendency during treatment. […] The differences in age, sex, and last CT scores determined before discharge between the two groups were analyzed, and correlations of the time from symptom onset to diagnosis and treatment with the time to disease resolution as well as with the highest CT score also underwent statistical analysis. RESULTS. A total of 25 subjects were enrolled in the study. […] The time from symptom onset to diagnosis and treatment had a positive correlation with the time to disease resolution (r = 0.93; p = 0.000) as well as with the highest CT score (r = 0.83; p = 0.006). CONCLUSION. Timely diagnosis and treatment are key to providing a better prognosis for patients with COVID-19. | 2020-03-31 |
| 32223840 | Objective: To collect the current status and healthcare needs of people living with HIV (PLHIV) in China during the COVID-19 outbreak to inform quick response from government and communities. Methods: During February 5(th) to 10(th) , 2020, a national anonymous survey was conducted using an online questionnaire among PLHIV at least 18 years of age and had started antiretroviral treatment (ART) to collect the information on COVID-19 prevention, HIV-related health services and the needs on psychosocial support. | 2020-03-31 |
| 32224151 | If the last anti-tumour treatment was within 14 days, it significantly increased the risk of developing severe events (HR=4.079, 95%CI 1.086-15.322, P=0.037). | 2020-03-31 |
| 32224769 | The topics were: 1) infection control, 2) laboratory diagnosis and specimens, 3) hemodynamic support, 4) ventilatory support, and 5) COVID-19 therapy. | 2020-03-31 |
| 32226003 | Thanks to the collaboration of experts worldwide, more information about this virus and its infection is reported each day, which allows modifying the recommendations for its prevention and treatment, without forgetting that the ultimate goal is to control this epidemic. | 2020-04-03 |
| 32226287 | Four patients required oxygen therapy but none of them needed machinal ventilation. | 2020-04-03 |
| 32226288 | No specific anti-virus drugs or vaccines are available for the treatment of this sudden and lethal disease. […] The supportive care and non-specific treatment to ameliorate the symptoms of the patient are the only options currently. […] At the top of these conventional therapies, greater than 85% of SARS-CoV-2 infected patients in China are receiving Traditional Chinese Medicine (TCM) treatment. […] In this article, relevant published literatures are thoroughly reviewed and current applications of TCM in the treatment of COVID-19 patients are analyzed. […] Due to the homology in epidemiology, genomics, and pathogenesis of the SARS-CoV-2 and SARS-CoV, and the widely use of TCM in the treatment of SARS-CoV, the clinical evidence showing the beneficial effect of TCM in the treatment of patients with SARS coronaviral infections are discussed. | 2020-04-03 |
| 32226289 | Therapeutic neutralizing antibodies (NAbs) against SARS-CoV-2 will be greatly important therapeutic agents for the treatment of coronavirus disease 2019 (COVID-19). | 2020-04-03 |
| 32226290 | Such knowledge will provide important clues for control of the ongoing epidemic of SARS-CoV-2 infection and treatment of COVID-19. | 2020-04-03 |
| 32226295 | We will cover the basics about the epidemiology, etiology, virology, diagnosis, treatment, prognosis, and prevention of the disease. | 2020-04-03 |
| 32226695 | Following this potential treatment options emerge. […] Other therapeutics to consider that are also directed towards decreased pulmonary pressure include Nifedipine and Phosphodiesterase inhibitors. […] The utilization of medications found to be effective in HAPE, for the treatment of COVID-19, is proposed. | 2020-04-02 |
| 32227090 | The finding of this study explains the high rate of severe cases among COVID-19 patients with basic cardiovascular disease; and these results also perhaps provide important reference to clinical treatment of cardiac injury among severe patients infected by SARS-CoV-2. | 2020-03-31 |
| 32227123 | The levels of peripheral lymphocyte subsets were measured by flow cytometry in 60 hospitalized COVID-19 patients before and after treatment, and their association with clinical characteristics and treatment efficacy was analyzed. […] After treatment, 37 patients (67%) reached clinical response, with an increase of CD8+ T cells and B cells. […] In multivariate analysis, post-treatment decrease of CD8+ T cells and B cells and increase of CD4+/CD8+ ratio were indicated as independent predictors for poor efficacy. […] Peripheral lymphocyte subset alteration was associated with the clinical characteristics and treatment efficacy of COVID-19. […] CD8+ T cells tended to be an independent predictor for COVID-19 severity and treatment efficacy. | 2020-03-31 |
| 32227197 | While influencing national health policies for revising screening criteria, this case also highlighted significant knowledge gaps in diagnosis and treatment and a desperate need for early, widespread, fast and cheap testing for COVID-19. | 2020-04-01 |
| 32227274 | Information on clinical signs and symptoms, medical treatment, virus clearance, and laboratory parameters including interleukin 6 (IL-6) and C-reactive protein were collected. […] Therapeutic regimens of IFN-α + lopinavir/ritonavir and IFN-α + lopinavir/ritonavir + ribavirin might be beneficial for treatment of COVID-19. […] Serum LDH or CK decline may predict a favorable response to treatment of COVID-19 infection. | 2020-03-31 |
| 32227357 | There is no specific treatment available and management is empirical. | 2020-03-31 |
| 32227493 | Confronting the challenge of the outbreak of COVID-19 should sharpen our focus on global drug access as a key issue in antiviral therapy testing. […] The apparent COVID-19 pandemic provides an opportunity to follow dosage guidelines for treatment with ribavirin, test new therapeutic concepts, and conduct controlled testing to apply the scientific rigor required to address the controversy around this mainstay of antiviral therapy. | 2020-04-10 |
| 32227596 | To outline strategies for the treatment of migraine which do not require in-person visits to clinic or the emergency department, and to describe ways that health insurance companies can remove barriers to quality care for migraine. […] We focus on evidence-based treatment where possible, but also describe “real world” strategies which may be tried. | 2020-04-13 |
| 32227609 | The COVID-19 outbreak in Italy is stopping access to elective benign disease treatment and changing the approach to malignant disease as well as the outpatients care of those patients treated for colorectal cancer. | 2020-03-31 |
| 32227758 | During the first 3 weeks of the Covid-19 outbreak in the Seattle area, the most common reasons for admission to the ICU were hypoxemic respiratory failure leading to mechanical ventilation, hypotension requiring vasopressor treatment, or both. | 2020-04-16 |
| 32228222 | We observed that patients receiving ACEI or ARB therapy had a lower rate of severe diseases and a trend toward a lower level of IL-6 in peripheral blood. […] In addition, ACEI or ARB therapy increased CD3 and CD8 T cell counts in peripheral blood and decreased the peak viral load compared to other antihypertensive drugs. | 2020-04-02 |
| 32228226 | The transcriptome dataset of COVID-19 patients would be a valuable resource for clinical guidance on anti-inflammatory medication and understanding the molecular mechansims of host response. | 2020-04-02 |
| 32228252 | In lieu of the fact that many older patients with hypertension or other CVDs are routinely treated with RAAS blockers and statins, new clinical concerns have developed regarding whether these patients are at greater risk for SARS-CoV-2 infection, whether RAAS and statin therapy should be discontinued, and the potential consequences of RAAS blockade to COVID-19-related pathologies such as acute and chronic respiratory disease. | 2020-04-16 |
| 32228809 | These findings might also serve as a practical reference for clinical diagnosis and medical treatment. | 2020-04-01 |
| 32228825 | Therefore, drugs that suppress IL-1 or IL-1R, also used for the treatment of rheumatoid arthritis are to be taken into consideration to treat COVID-19. | 2020-04-01 |
| 32228827 | Finally, the apparently accurate treatment prediction platform (EpiMed) independently developed by the team was used to predict the therapeutic drug. Results: The GSE59185 coronavirus data set was searched and screened in the GEO database, and divided into wt group, ΔE group, Δ3 group, Δ5 group according to different subtypes, and compared with control group. […] The drugs predicted by EpiMed’s apparent precision treatment prediction platform for disease-drug association analysis are mainly TNF-α inhibitors, resveratrol, ritonavir, paeony, retinoic acid, forsythia, and houttuynia cordata. Conclusions: The abnormal activation of multiple inflammatory pathways may be the cause of heart failure in patients after coronavirus infection. | 2020-04-01 |
| 32229257 | The objective of this study is to investigate the short-term effect of risk-adapted treatment strategy on patients with COVID-19. […] We divided these patients into mild, moderate and severe groups, and risk-adapted treatment approaches were given according to the illness severity. […] Risk-adapted treatment strategy was associated with significant clinical manifestations alleviation and clinical imaging recovery. | 2020-04-01 |
| 32229706 | Similarly, two proposed therapeutics for the treatment of COVID-19 infection are Azithromycin and Quercetin, both drugs with significant senolytic activity. […] Therefore, we wish to speculate that the fight against COVID-19 disease should involve testing the hypothesis that senolytics and other anti-aging drugs may have a prominent role in preventing the transmission of the virus, as well as aid in its treatment. […] Thus, we propose that new clinical trials may be warranted, as several senolytic and anti-aging therapeutics are existing FDA-approved drugs, with excellent safety profiles, and would be readily available for drug repurposing efforts. […] As Azithromycin and Doxycycline are both commonly used antibiotics that inhibit viral replication and IL-6 production, we may want to consider this general class of antibiotics that functionally inhibits cellular protein synthesis as a side-effect, for the treatment and prevention of COVID-19 disease. | 2020-04-01 |
| 32229732 | The recorded information includes demographic data, medical history, contact history, potential comorbidities, symptoms, signs, laboratory test results, chest computer tomography scans, and treatment measures. […] In addition, 5 patients with CKD who were undergone regular continuous renal replacement therapy (CRRT) before admission were confirmed infection of SARS-CoV-2 and diagnosed as COVID-19. […] In addition to therapy for COVID-19, CRRT was also applied 3 times weekly during hospitalization for these 5 patients with CKD. […] In the course of treatment, the renal function indicators showed stable state in all 5 patients with CKD, without exacerbation of CKD, and pulmonary inflammation was gradually absorbed. | 2020-04-01 |
| 32230900 | Scientific advancements since the pandemic of severe acute respiratory syndrome (SARS) in 2002~2003 and Middle East respiratory syndrome (MERS) in 2012 have accelerated our understanding of the epidemiology and pathogenesis of SARS-CoV-2 and the development of therapeutics to treat viral infection. […] As no specific therapeutics and vaccines are available for disease control, the epidemic of COVID-19 is posing a great threat for global public health. | 2020-04-03 |
| 32231345 | To develop specific anti-coronavirus therapeutics and prophylactics, the molecular mechanism that underlies viral infection must first be defined. […] Intranasal application of EK1C4 before or after challenge with HCoV-OC43 protected mice from infection, suggesting that EK1C4 could be used for prevention and treatment of infection by the currently circulating SARS-CoV-2 and other emerging SARSr-CoVs. | 2020-04-07 |
| 32231348 | WHO has accelerated research in diagnostics, vaccines and therapeutics for this novel coronavirus. | 2020-04-02 |
| 32232214 | There is still no vaccine or definitive treatment for this virus because its pathogenesis and proliferation pathways are still unknown. | 2020-04-04 |
| 32232230 | As one of the busiest specialised hospitals in the world, the Department of Oral and Maxillofacial Surgery of Peking University School and Hospital of Stomatology summarised the experience with disease prevention and control and clinical recommendations on the examination, diagnosis and treatment processes, clinical management, healthcare personnel protection and disinfection amid the continued spread of the pandemic. | 2020-04-02 |
| 32232423 | The most common procedures related to the examination and treatment of upper aerodigestive tract diseases were reviewed. | 2020-04-01 |
| 32232432 | This paper discusses proposed changes to privacy regulations such as the Health Insurance Portability and Accountability act (HIPAA) designed to let health information seamlessly and frictionlessly flow between the health entities that need to collaborate on treatment of patients and, also, allow it to flow to researchers trying to understand how to limit its impacts. | 2020-04-01 |
| 32232433 | During the period of treatment, the ocular signs and symptoms as well as results of blood tests and reverse transcriptase-polymerase chain reaction (RT-PCR) from nasopharyngeal and conjunctival swabs for SARS-CoV-2 were noted and analyzed. | 2020-04-04 |
| 32232685 | Most of the critically ill patients received high-flow nasal cannula (HFNC) oxygen therapy. […] Among them, 27 (8.4%) patients experienced severe acute respiratory failure including 17 patients (63%) treated with HFNC as first-line therapy, 9 patients (33%) treated with noninvasive ventilation (NIV) and one patient (4%) treated with invasive ventilation. […] HFNC failure was defined by the need of NIV or intubation as rescue therapy. […] After initiation of NIV as rescue therapy among the 7 patients with HFNC failure, PaO2/FiO2 significantly improved after 1-2 h of NIV [median 172 (150-208) mmHg vs. […] However, two out of seven (29%) patients with NIV as rescue therapy ultimately received intubation. | 2020-04-03 |
| 32233013 | Demographic data, medical history, symptoms and signs, laboratory findings, chest computed tomography (CT) as well the treatment measures were collected and analysed. | 2020-04-08 |
| 32233018 | Targeting the overexpression of Il-6 effects with a monoclonal antibody against IL-6 receptor or using Janus Kinase inhibitors may be particularly helpful for treatment of Covid-19 pneumonia in diabetes. | 2020-04-14 |
| 32233064 | It is prudent to stop non-cancer procedures and prioritize urgent cancer treatment. | 2020-04-02 |
| 32233561 | The absence of specific therapeutic treatment or effective vaccine against COVID-19 call for other avenues of the prevention and control measures. | 2020-04-09 |
| 32233563 | More rigorous prevention measures and better treatment of patients are needed to control its further spread, e.g., increasing available hospital beds, shortening the period from symptom onset to isolation of patients, quarantining and isolating the suspected cases as well as all confirmed patients. | 2020-04-09 |
| 32233641 | Currently, no effective medical treatment exists to combat this disease. […] Traditional Chinese herbal medicines (CHM) have unique roles in the treatment of viral infections. | 2020-04-13 |
| 32233642 | All the patients received standardized treatment. | 2020-04-13 |
| 32233816 | Antibiotic and antiviral treatment was initiated. | 2020-04-16 |
| 32233973 | Satisfactory outcome was observed in one mild case and one severe case of COVID-19 pneumonia after the use of the online/offline multidisciplinary quarantine observation form, online monitoring, and classified diagnosis and treatment, as well as strict compliance with quarantine measures. […] The multidisciplinary self-quarantine model provides early judgment, identification, and treatment of disease, improves compliance with early rehabilitation, increases confidence in recovery, and enhances self-management capabilities. […] The application of this new management model is worthy of being promoted in our specialized treatment facilities and in countries with severe epidemics. | 2020-04-02 |
| 32234126 | The current etiological test of COVID-19 cost long time, and have high false negative rate, may resulting delay the measures of disease treatment and prevention. | 2020-04-02 |
| 32234131 | After 3 to 5 days of treatment, 2019-nCoV nucleic acid in a second respiratory sample turned negative in 6 cases. | 2020-04-03 |
| 32234465 | Here we scrutinise a series of available studies by global scientists on the clinical manifestations, detection methods and treatment options for the disease caused by SARS-CoV-2, named coronavirus disease 2019 (COVID-19), and also propose potential strategies for preventing the infection. | 2020-04-15 |
| 32234466 | Intensive research on the newly emerged SARS-CoV-2 is urgently needed to elucidate the pathogenic mechanisms and epidemiological characteristics and to identify potential drug targets, which will contribute to the development of effective prevention and treatment strategies. | 2020-04-11 |
| 32234467 | Therefore, the treatment of cytokine storm has become an important part of rescuing severe patients. […] If it can block the signal transduction pathway of IL-6, it is expected to become a new method for the treatment of severe patients. | 2020-04-09 |
| 32234468 | In addition, registered trials investigating treatment options for COVID-19 infection are listed. | 2020-04-09 |
| 32235161 | A third survey collected current practice of PIBD treatment. […] Eight PIBD children had COVID-19 globally, all with mild infection without needing hospitalization despite treatment with immunomodulators and/or biologics. […] No cases have been reported in China and South Korea but biologic treatment has been delayed in 79 children, of whom 17 (22%) had exacerbation of their IBD. […] Among the Porto group members, face-to-face appointments were often replaced by remote consultations but almost all did not change current IBD treatment. | 2020-04-08 |
| 32235486 | Data on treatment options were limited. | 2020-04-02 |
| 32235575 | Although no vaccines have been discovered yet, a series of containment measures have been implemented by various governments, especially in China, in the effort to prevent further outbreak, whilst various medical treatment approaches have been used to successfully treat infected patients. […] On the basis of current studies, it would appear that the combined antiviral treatment has shown the highest success rate. […] This review aims to critically summarize the most recent advances in understanding the coronavirus, as well as the strategies in prevention and treatment. | 2020-04-08 |
| 32236089 | The entire healthcare system had to respond promptly in a very short time to an exponential growth of the number of subjects affected by COVID-19 (Coronavirus disease 2019) with the need of semi-intensive and intensive care units. | 2020-04-02 |
| 32236624 | In the present review, we address current knowledge on coronaviruses from a short history to epidemiology, pathogenesis, clinical manifestation of the disease, as well as treatment and prevention strategies. | 2020-04-02 |
| 32236983 | As yet, effective treatment is unavailable. […] However, the results of preliminary studies and clinical trials are improving our understanding of the pathogenesis and treatment of Covid-19. | 2020-04-02 |
| 32237160 | Chinese medical staff have summarized a set of effective strategies and methods in the diagnosis and treatment of this disease that are worthy of reference for their international counterparts. | 2020-04-10 |
| 32237206 | Furthermore, the rising prevalence of obesity in the US and prior experience of the impact of obesity on mortality from H1 N1 Influenza should increase the sensitivity of clinicians caring for patients with obesity and COVID-19 to the need for aggressive treatment of such patients. | 2020-04-02 |
| 32237998 | It is unknown if dermatologists are assisting with the public health officials’ recommendations for social distancing by closing their practice or limiting their practice to the treatment of emergency conditions. | 2020-04-15 |
| 32238232 | Thus, treatment approaches should include antiviral and anti-proinflammatory cytokines, anti-infectious and life support therapies, especially in patients with severe diseases. | 2020-04-02 |
| 32238260 | Thus leading to a delay in the diagnosis of COVID-19 infection and further spread of the virus, since in most cases of Dengue there are no warning signs and treatment is ambulatory. | 2020-04-08 |
| 32238504 | Neurologists are used to uncertainty - diagnoses are frequently challenging, too often there are limited treatment options, and unpredictable prognoses are our bread and butter. | 2020-04-02 |
| 32238613 | It is important to recognize the risk factors, categorize severity and provide early treatment. | 2020-04-16 |
| 32238757 | Currently, various diagnostic kits to test for COVID-19 are available and several repurposing therapeutics for COVID-19 have shown to be clinically effective. […] Here, we review the current status of epidemiology, diagnosis, treatment, and vaccine development for COVID-19. | 2020-04-10 |
| 32239127 | Epidemiological, clinical, radiological characteristics, underlying diseases, laboratory tests treatment, complications and outcomes data were collected. […] There was no difference in drug treatment rates between the survival and non-survival groups. […] There were no differences in mortality among those who did or did not receive antimicrobial or glucocorticoid drug treatment. | 2020-04-02 |
| 32239142 | Since the preclinical or clinical information of these identified drugs is already available, they might be ready for being clinically tested in the treatment of COVID-19. | 2020-04-02 |
| 32239799 | Coagulopathy in corona virus infection has been shown to be associated with high mortality with high D-dimers being a particularly important marker for the coagulopathy.1 In the latest paper from the same group, the use of anticoagulant therapy with heparin was shown to decrease mortality as well. 2 This is especially so in patients i) who have met the sepsis induced coagulopathy (SIC) criteria ≥4 (40.0% vs 64.2%, P=0.029) compared to those with SIC score <4 (29.0% vs 22.6%, P=0.419).or ii) with markedly elevated D-dimer (greater than six-fold at the upper limit of normal). | 2020-04-02 |
| 32240303 | Emergent policy changes related to telemedicine and the Emergency Medical Treatment and Labor Act (EMTALA) during the novel coronavirus pandemic (COVID-19) have created opportunities for technology-based clinical evaluation, which serves to conserve personal protective equipment (PPE) and protect emergency providers. | 2020-04-02 |
| 32240462 | Apart from supportive care, no specific treatment has been established for COVID-19. | 2020-04-02 |
| 32240567 | While in our centre we did not change our approach to the treatment of our young cancer patients, we developed a qualitative survey to assess their perception of the risk and level of stress. | 2020-04-09 |
| 32240670 | Close monitoring and timely treatment should be performed for the elderly patients at high risk. | 2020-04-14 |
| 32240751 | Palliative care teams may consider expanding their communication training and skillsets to help families consider caring ways to communicate with their children and grandchildren about the coronavirus. […] Palliative care teams are wise to encourage families to ground their communication with children on key values: honesty and trust, self-compassion, safety, sensitivity, connection, preparedness, community-building, recognition of death as a part of the lifecycle, and legacy. | 2020-04-02 |
| 32240752 | We propose that the palliative care team response will occur in two ways: first, communication and second, symptom management. […] We also propose a framework for proactively mobilizing the palliative care workforce to aggressively address goals of care in all patients, with the aim of reducing the need for rationing of resources. | 2020-04-03 |
| 32240754 | Therefore, palliative care is an important part of the response to this pandemic. […] UW Medicine developed a strategy to implement a palliative care response for a multi-hospital healthcare system that incorporates conventional capacity, contingency capacity, and crisis capacity. […] The strategy was developed by our palliative care programs with input from the healthcare system leadership. […] In this publication, we share our multi-faceted strategy to implement high-quality palliative care in the context of the COVID-19 pandemic that incorporates conventional, contingency, and crisis capacity and focuses on the areas of the hospital caring for the most patients: the emergency department, the intensive care units, and the acute care services. […] Strategy planning for delivery of high-quality palliative care in the context of the COVID-19 pandemic represents an important area of need for our healthcare systems. | 2020-04-02 |
| 32240756 | Within weeks, COVID-19 has transformed our practice of palliative care and clinical medicine as we know it. […] In this article, we share just-in-time tips to support palliative care clinicians and program leaders in providing the best care possible by telemedicine. | 2020-04-02 |
| 32241056 | Finally, some suggestions for thoracic surgery clinical practice in non-epidemic area during and after the epidemic of COVID-19 were provided, to help all the thoracic surgery patients receive active and effective treatment. | 2020-04-03 |
| 32241244 | Since most patients with COVID-19 infection share typical imaging features, radiological examinations have an irreplaceable role in screening, diagnosis and monitoring treatment effects in clinical practice. | 2020-04-03 |
| 32242347 | To allocate medical resources efficiently, Korea implemented a novel institution for the purpose of treating patients with cohort isolation out of hospital, namely the Community Treatment Center (CTC). | 2020-04-06 |
| 32242348 | Six patients (21.4%) required supplemental oxygen therapy, but no one needed mechanical ventilation. | 2020-04-06 |
| 32242438 | Mild cases can be managed at home with self-isolation, symptomatic treatment and follow-up if the disease worsens. | 2020-04-08 |
| 32242947 | We aim to explore reliable evidence for the diagnosis and treatment of the COVID-19 by analyzing all the published studies by Chinese scholars on the clinical and imaging features in novel coronavirus pneumonia caused by SARS-CoV-2. | 2020-04-10 |
| 32243304 | Analyses of early prognosis were based on clinical outcomes and trends in laboratory results during treatment. […] Surgical treatment should be carried out cautiously or nonoperative care should be chosen for patients with fracture in COVID-19-affected areas, especially older individuals with intertrochanteric fractures. | 2020-04-03 |
| 32243668 | Many cancer patients frequently visit the hospital for treatment and disease surveillance. […] They may be immunocompromised due to the underlying malignancy or anticancer therapy and are at higher risk of developing infections. | 2020-04-05 |
| 32243690 | Based on the severity of clinical symptoms, chest computer tomography findings and SARS-Cov-2 RNA test results, we admitted the husband to the respiratory intensive care unit (RICU) and used a treatment consisting of immunosuppressant reduction/cessation and low dose methylprednisolone-based therapy, and his wife to the respiratory isolation ward. | 2020-04-03 |
| 32243697 | Both patients were on immunosuppressant therapy and had stable graft function before COVID-19 infection. | 2020-04-03 |
| 32243911 | COVID-19 is a new infectious disease, for which there is currently no treatment. | 2020-04-15 |
| 32243945 | Although all the four patients (including a pregnant woman) recovered from SARS-CoV-2 infection eventually, randomized trials are needed to eliminate the effect of other treatments and investigate the safety and efficacy of convalescent plasma therapy. | 2020-04-03 |
| 32244059 | Currently, there is no proven effective therapy against the virus, and the impact on other diseases is also uncertain, especially inherited arrhythmia syndrome. | 2020-04-16 |
| 32245083 | The scientific community raced to uncover the origin of the virus, understand the pathogenesis of the disease, develop treatment options, define the risk factors, and work on vaccine development. | 2020-04-06 |
| 32245264 | The COVID-19 coronavirus is currently spreading around the globe with limited treatment options available. […] This article presents the rationale for potentially using old drugs (emetine, other ipecac alkaloids or analogues) that have been used to treat amoebiasis in the treatment of COVID-19. […] This paper also discusses the known side effects of emetine and related compounds, how those side effects can be managed, and the optimal method of administration for the potential treatment of COVID-19. […] Given the serious and immediate threat that the COVID-19 coronavirus poses, our long history with emetine and the likely ability of emetine to reach therapeutic concentrations within the lungs, ipecac, emetine, and other analogues should be considered as potential treatment options, especially if in vitro studies confirm viral sensitivity. | 2020-04-06 |
| 32245395 | In this Commentary, we would like to comment on the article titled “A rapid advice guideline for the diagnosis and treatment of 2019 novel coronavirus (2019-nCoV) infected pneumonia (standard version)” as a featured article in Military Medical Research. | 2020-04-10 |
| 32245396 | On 6 February 2020, our team had published a rapid advice guideline for diagnosis and treatment of 2019 novel coronavirus (2019-nCoV) infection, and this guideline provided our experience and make well reference for fighting against this pandemic worldwide. […] However, the coronavirus disease 2019 (COVID-19) is a new disease, our awareness and knowledge are gradually increasing based on the ongoing research findings and clinical practice experience; hence, the strategies of diagnosis and treatment are also continually updated. […] In this letter, we answered one comment on our guideline and provided the newest diagnostic criteria of “suspected case” and “confirmed case” according to the latest Diagnosis and Treatment Guidelines for COVID-19 (seventh version) that issued by the National Health Committee of the People’s Republic of China. | 2020-04-10 |
| 32245590 | Meanwhile, Traditional Chinese Medicine can provide the more effective and personalized treatment via adjusting the specific medicine for each patient based on the different syndromes. […] In addition, TCM often has different effect on the distinct stages of diseases, contributing to the prevention, treatment and rehabilitation. […] Therefore, it is convinced that Traditional Chinese Medicine is an effective treatment for 2019 novel coronavirus pneumonia. | 2020-04-08 |
| 32245814 | Hospital beds, intensive care units (ICUs), and ventilators are vital for the treatment of patients with severe illness. […] In scenario analyses, we varied the delay from symptom onset to self-isolation, the proportion of symptomatic individuals practicing self-isolation, and the basic reproduction number R0 Without self-isolation, when R0 = 2.5, treatment of critically ill individuals at the outbreak peak would require 3.8 times more ICU beds than exist in the United States. | 2020-04-04 |
| 32245904 | To date, no effective treatment has been identified and management for critically ill patients relies on management in intensive care units. […] Therefore, the risk/benefit ratio of systemic anticancer treatment (SACT) has to be considered. […] For each patient, several factors including age and comorbidities, as well as the number of hospital visits for treatment, can influence this risk. […] We hereby propose a tool to support oncologists and physicians in treatment decision for patients with lung cancer. […] There are several variables to consider, including the extent of the epidemic, the local healthcare structure capacity, the risk of infection to the individual, the status of cancer, patients’ comorbidities, age and details of the treatment. | 2020-04-10 |
| 32246280 | All the 48 public tertiary dental hospitals suspended general non-emergency dental treatment while providing emergency dental services only. | 2020-04-04 |
| 32246317 | Whether patients with elevated D-dimer could benefit from anticoagulant treatment was evaluated. […] Patients with severe pneumonia induced by SARS-CoV2 had higher platelet count than those induced by non-SARS-CoV2, and only the former with markedly elevated D-dimer may benefit from anticoagulant treatment. | 2020-04-04 |
| 32246787 | In this paper we summarize what is known about the stress-sleep link and confinement as well as effective insomnia treatment. […] We suggest adaptions of cognitive behavioral therapy elements that are feasible to implement for those facing changed work schedules and requirements, those with health anxiety and those handling childcare and homeschooling, whilst also recognizing the general limitations imposed on physical exercise and social interaction. | 2020-04-04 |
| 32246834 | No specific antiviral drugs have been approved for the treatment of COVID-2019. | 2020-04-04 |
| 32246879 | Over the past few decades, several blood-borne viruses have targeted hemophilia patients requiring treatment with clotting factors derived from human plasma [1]. | 2020-04-04 |
| 32247050 | Based on recently published literatures, official documents and selected up-to-date preprint studies, we reviewed the virology and origin, epidemiology, clinical manifestations, pathology and treatment of 2019-nCoV infection, in comparison with severe acute respiratory syndrome coronavirus (SARS-CoV) and middle east respiratory syndrome coronavirus (MERS-CoV) infection. | 2020-04-07 |
| 32247056 | Specialist Palliative Care services (SPCS) have a vital role to play in the global COVID-19 pandemic. […] SPCS resource capacity is likely to be overwhelmed, and consideration needs to be given to empowering and supporting high-quality primary palliative care in all care locations. […] Our local SPCS have developed a Palliative Care Pandemic Pack to disseminate succinct and specific information, guidance, and resources designed to enable the rapid up-skilling of non-specialist clinicians needing to provide palliative care. | 2020-04-04 |
| 32247066 | For cervical cancer, radiotherapy and concomitant radiochemotherapy could replace surgery as first-line treatment and the value of lymph node staging should be reviewed on a case-by-case basis. | 2020-04-13 |
| 32247211 | Considering minimal risk upon use, a long experience of use in other diseases, cost-effectiveness and easy availability across India, we propose that both these drugs are worthy of fast track clinical trial for treatment, and may be carefully considered for clinical use as experimental drugs. […] Since HCQ has been approved for treatment of diabetes in India, it should be further researched in diabetes and COVID-19, a subgroup where significant mortality has been shown. | 2020-04-10 |
| 32247213 | Search terms were, COVID-19, treatment of coronavirus, COVID 19 and following terms; chloroquine, hydroxychloroquine, ibuprofen, ACE-inhibitors or angiotensin receptor blockers, cardiovascular disease, diarrhoea, liver, testis and gastrointestinal disease. […] We discuss evidence regarding role of chloroquine and hydroxychloroquine in treatment and prophylaxis, use of inhibitors of the renin angiotensin system, safety of ibuprofen, unusual clinical features like gastrointestinal symptoms and interpretation of tests for cardiac enzymes and biomarkers. | 2020-04-16 |
| 32247898 | This paper will attempt to estimate global infection rates and potential resultant mortality in the absence of effective treatment and/or vaccination. | 2020-04-05 |
| 32247927 | The first medication experience of the recovered patients in the US has led remdesivir to be the “specific drug”. […] China has also taken immediate action to put remdesivir into clinical trials with the purpose of applying it into clinical therapeutics for Corona Virus Disease 2019 (COVID-19). | 2020-04-14 |
| 32248387 | This opinion article discusses the increasing attention paid to the role of activating damage-associated molecular patterns (DAMPs) in initiation of inflammatory diseases and suppressing/inhibiting DAMPs (SAMPs) in resolution of inflammatory diseases and, consequently, to the future roles of these novel biomarkers as therapeutic targets and therapeutics. […] For example, we discuss the need to a priori identify and define a context-dependent “homeostatic DAMP:SAMP ratio” in each case and a “homeostatic window” of DAMP and SAMP concentrations to guarantee a safe treatment modality to patients. […] Finally, a few clinical examples of how DAMPs and SAMPs might be used as therapeutic targets or therapeutics in the future are discussed, including inhibition of DAMPs in hyperinflammatory processes (e.g., systemic inflammatory response syndrome, as currently observed in Covid-19), administration of SAMPs in chronic inflammatory diseases, inhibition of SAMPs in hyperresolving processes (e.g., compensatory anti-inflammatory response syndrome), and administration/induction of DAMPs in vaccination procedures and anti-cancer therapy. | 2020-04-05 |
| 32248521 | We also provide guidance on the medical treatment of pregnant women with COVID-19 infection. | 2020-04-05 |
| 32248675 | Three multidisciplinary intensive care units (ICUs) in Hong Kong. […] Six patients (75%) required mechanical ventilation, six patients (75%) required vasopressors and two (25%) required renal replacement therapy. | 2020-04-06 |
| 32248966 | Given the novel nature of COVID-19, no established treatment beyond supportive care exists currently, but extensive public-health measures to reduce person-to-person transmission of COVID-19 have been implemented globally to curb the spread of disease, reduce the burden on healthcare systems, and protect vulnerable populations, including the elderly and those with underlying medical comorbidities. | 2020-04-09 |
| 32249063 | To meet this challenge, this article discusses advances in the research and development of neutralizing antibodies (nAbs) for the prevention and treatment of infection by SARS-CoV-2 and other human CoVs. | 2020-04-09 |
| 32249089 | Four patients received a reduced dose of maintenance immunosuppressive therapy during hospitalization. […] Although greater patient numbers and long-term follow-up data are needed, our series demonstrates that mild COVID-19 infection in KTx recipients can be managed using symptomatic support therapy combined with adjusted maintenance immunosuppressive therapy. | 2020-04-06 |
| 32249102 | Particularly, the community patient population are at high risk of infection and are facing potential failure of proper medication use during the pandemic. […] Pharmacists shall use various approaches to provide PC services in drug dispensing, consulting and referrals, chronic disease management, safe use of infusions, patient education, home care guidance and psychological support to promote the COVID-19 pandemic control and ensure safe medication use of community patients during the pandemic. […] Community pharmacies shall work as a strong supporter of patient’s medication and protective equipment supply. […] Community pharmacists shall be prepared to provide skilled and effective PC services for community patient population to ensure medication safety and promote the overall COVID-19 pandemic control. | 2020-04-09 |
| 32249257 | With no vaccines or drugs approved for prevention and treatment until now, all efforts at drug design and/or clinical trials of already approved drugs are worthy and creditable. […] Very recently, hydroxychloroquine in combination with azithromycin treatment was reported to be effective for COVID-19. | 2020-04-06 |
| 32249357 | Nonetheless, evidence from previous influenza pandemics suggests the following interventions aimed at improving immune response: (1) lose weight with a mild caloric restriction; (2) include AMPK activators and PPAR gamma activators in the drug treatment for obesity associated with diabetes; and (3) practice mild-to-moderate physical exercise. | 2020-04-06 |
| 32249943 | Antiviral therapy was given to all adult patients but to none of the children. | 2020-04-06 |
| 32250049 | We present the case of a 32-day-old boy infected by COVID-19 that presented with an upper air way infection which resolved spontaneously and did not require any therapy. | 2020-04-06 |
| 32250170 | Plant biotechnology offers potential solutions to this pandemic through the development of low-cost vaccines and antibodies useful for therapy, prophylaxis, and diagnosis. | 2020-04-16 |
| 32250244 | Based on the current clinical evidence treatment with ACE-inhibitors I (ACEis) or angiotensin receptor blockers (ARBs) continues to provide cardiovascular and renal protection in patients diagnosed with COVID-19. | 2020-04-15 |
| 32250347 | In December 2019, in the city of Wuhan, in the Hubei province of China, treatment-resistant cases of pneumonia emerged and spread rapidly for reasons unknown. | 2020-04-10 |
| 32250385 | To characterize patients with coronavirus disease 2019 (COVID-19) requiring treatment in an intensive care unit (ICU) in the Lombardy region of Italy. | 2020-04-09 |
| 32251003 | Lung transplantation (LT) as the sole therapy for end-stage pulmonary fibrosis related to acute respiratory distress syndrome has been considered as the ultimate rescue therapy for these patients. | 2020-04-06 |
| 32251618 | PubMed, Google Scholar and Science Direct databases were searched Results: A total 22 articles were found eligible. 8 discuss about treatment outcomes from their applied drugs during treatment of COVID-19 patients, 4 report laboratory tests, one report animal trial and other 9 articles discuss recommendations and suggestions based on the treatment process and clinical outcomes of other diseases such as malaria, ebola, severe acute respiratory syndrome (SARS) and Middle East respiratory syndrome (MERS). | 2020-04-13 |
| 32251634 | Ribavirin, telbivudine, vitamin B12 and nicotinamide can be combined and used for COVID treatment. […] This initiative relocates already marketed and approved safe drugs for potential use in COVID-treatment. | 2020-04-16 |
| 32251717 | This is distinct from HLH associated with immunodeficiency states termed primary HLH -with radically different therapy strategies in both situations. […] We discuss the potential impact of timing of anti-cytokine therapy on viral clearance and the impact of such therapy on intra-pulmonary macrophage activation and emergent pulmonary vascular disease. | 2020-04-10 |
| 32251731 | Given the global health emergency, drug repositioning is the most reliable option to design an efficient therapy for infected patients without delay. […] Using a combination of structural and molecular modelling approaches, this study showed that chloroquine (CLQ), one of the drugs currently under investigation for SARS-CoV-2 treatment, binds sialic acids and gangliosides with high affinity. | 2020-04-14 |
| 32251767 | Combinational therapy may help to reduce the effective concentration of compounds below the therapeutic plasma concentrations and provide better clinical benefits. | 2020-04-16 |
| 32251794 | To date, no specific treatment has been proven to be effective for SARS-CoV-2 infection. […] Given to the previous experience, extracorporeal membrane oxygenation (ECMO) has been proven to be an effective therapy in the treatment of respiratory failure or acute respiratory distress syndrome (ARDS). […] On the basis of similar principle, ECMO may be also an effective therapy in the treatment of severe COVID-19. | 2020-04-06 |
| 32251796 | One patient was discharged within 14 days after treatment. […] Another patient was discharged 25 days after treatment, and his TR-PCR test was still positive on the 15th day. | 2020-04-09 |
| 32252338 | For treatment of people who become infected with COVID-19, higher vitamin D3 doses might be useful. | 2020-04-10 |
| 32252979 | Due to the current pandemic of respiratory disease known as coronavirus disease 2019 (COVID-19) caused by the SARS-CoV-2 virus, many patients with confirmed or suspected COVID-19 infection will require elective surgery, surgery that cannot be postponed, or emergency surgical treatment. […] This document explains the main principles to consider when managing confirmed or suspected COVID-19 patients during evaluation as well as when surgical treatment is required. | 2020-04-10 |
| 32253068 | The management includes ventilatory support and broad-spectrum antiviral drugs, empirically utilized, as a targeted therapy and vaccines have not been developed. […] Checkpoints inhibitors such as anti-CD200 and anti-PD1 could have a role in the treatment of CoViD-19. […] Rheumatic disease patients taking immunosuppressive drugs should be recommended to maintain the chronic therapy, prevent infection by avoiding social contacts and pausing immunosuppressants in case of infection. | 2020-04-15 |
| 32253318 | This study showed CP therapy was well tolerated and could potentially improve the clinical outcomes through neutralizing viremia in severe COVID-19 cases. […] The optimal dose and time point, as well as the clinical benefit of CP therapy, needs further investigation in larger well-controlled trials. | 2020-04-07 |
| 32253400 | Loquat leaves have long been used as an important material for both pharmaceutical and functional applications in the treatment of lung disease in Asia, especially in China and Japan. […] TF treatment significantly inhibited the level of malondialdehyde (MDA) and increased the activity of superoxide dismutase (SOD). […] It suggested that TF derived from loquat leaves could be considered to be an alternative or a new functional material and used for the treatment of CS-induced COPD. | 2020-04-07 |
| 32253759 | Tocilizumab (TCZ), a monoclonal antibody against interleukin-6 (IL-6), emerged as an alternative treatment for COVID-19 patients with a risk of cytokine storms recently. […] In the present study, we aimed to discuss the treatment response of TCZ therapy in COVID-19 infected patients. […] The demographic, treatment, laboratory parameters of C-reactive protein (CRP) and IL-6 before and after TCZ therapy and clinical outcome in the 15 COVID-19 patients were retrospectively assessed. […] Although TCZ treatment ameliorated the increased CRP in all patients rapidly, for the four critically ill patients who received an only single dose of TCZ, three of them (No. 1, 2, and 3) still dead and the CRP level in the rest one patient (No. 7) failed to return to normal range with a clinical outcome of disease aggravation. […] Serum IL-6 level tended to further spiked firstly and then decreased after TCZ therapy in 10 patients. […] A persistent and dramatic increase of IL-6 was observed in these four patients who failed treatment. […] TCZ appears to be an effective treatment option in COVID-19 patients with a risk of cytokine storms. | 2020-04-15 |
| 32253799 | It is distinguishable by its longer incubation period, more varied morphology with initially urticarial and later targetoid and arcuate plaques, recalcitrance to therapy and longer duration. | 2020-04-16 |
| 32253888 | It is hoped that certain drugs, such as CoV-19 receptor blockers, anti-inflammatories (against rheumatic diseases), monoclonal antibodies, anti-IL-1 and anti-IL-6, the remdesevir drug (analogue adenosine, effective against ebola), hydroxychloroquine (for the treatment of malaria) and vaccines, will open up new strategies and new therapeutic ways to combat this terrible virus. | 2020-04-15 |
| 32253890 | This article analyzes the challenges of medical education in the dilemma of “separation of medical treatment and prevention”, and the new requirements for preventive medical education in the construction of New Medicine under the Healthy China strategy. | 2020-04-07 |
| 32253891 | As a newly epidemic, COVID-19 with a concentrated outbreak poses a great challenge to medical treatment. […] The surgeon participated in emergency medical rescue could provide professional treatment for the patients combined with surgical diseases, specialized training for the non-surgeon crew, to reduce surgical-related mortality. | 2020-04-07 |
| 32254064 | To date, there are no proven options for prophylaxis for those who have been exposed to SARS-CoV-2, nor therapy for those who develop COVID-19. […] There are numerous examples, where convalescent plasma has been used successfully as post-exposure prophylaxis and/or treatment of infectious diseases, including other outbreaks of coronaviruses (e.g., SARS-1, Middle East Respiratory Syndrome [MERS]). […] Data from rigorously controlled clinical trials of convalescent plasma are also few, underscoring the need to evaluate its use objectively for a range of indications (e.g., prevention vs treatment) and patient populations (e.g., age, comorbid disease). | 2020-04-07 |
| 32255382 | Demographic, clinical, laboratory, and treatment data were collected and analyzed, and final date of follow-up was February 24, 2020. | 2020-04-07 |
| 32255489 | Hydroxychloroquine (HCQ) appears to be a promising treatment for COVID-19. | 2020-04-07 |
| 32255510 | In patients with suspected or confirmed COVID-19 disease, all immunomodulators used for skin diseases should be immediately withheld, with the possible exception of systemic corticosteroid therapy, which needs to be weaned. | 2020-04-07 |
| 32256547 | More than 80 clinical trials have been launched to test coronavirus treatment, including some drug repurposing or repositioning for COVID-19. | 2020-04-09 |
| 32256705 | No conclusive evidence for or against the use of non-steroidal anti-inflammatory drugs (NSAIDs) in the treatment of COVID-19 patients is available, nor is there evidence indicating that TNFα blockade is harmful to patients in the context of COVID-19. […] Although there are potential targets in the JAK-STAT pathway that can be manipulated in treatment for coronaviruses and it is evident that IL-1 is elevated in patients with a coronavirus, there is currently no evidence for a role of these drugs in treatment of COVID-19. […] The COVID-19 pandemic has led to challenging decision-making about treatment of critically unwell patients. | 2020-04-09 |
| 32257537 | Among them, two common and one severe patient were recovered and discharged in 10 days after treatment. […] After treatment, the peripheral lymphocytes were increased, the C-reactive protein decreased, and the overactivated cytokine-secreting immune cells CXCR3+CD4+ T cells, CXCR3+CD8+ T cells, and CXCR3+ NK cells disappeared in 3-6 days. […] Meanwhile, the level of TNF-α was significantly decreased, while IL-10 increased in MSC treatment group compared to the placebo control group. […] Thus, the intravenous transplantation of MSCs was safe and effective for treatment in patients with COVID-19 pneumonia, especially for the patients in critically severe condition. | 2020-04-09 |
| 32257554 | Therefore, MSC therapy inhibiting the overactivation of the immune system and promoting endogenous repair by improving the lung microenvironment after the SARS-CoV-2 infection found in this study is striking. | 2020-04-09 |
| 32258207 | Until now, no definite effective treatment has been identified. | 2020-04-09 |
| 32258351 | In particular, the current coronavirus disease 2019 (COVID-19) pandemic has quickly intensified interest in developing treatment options to mitigate impact on human life. […] Remdesivir (GS-5734™) is a broad-spectrum antiviral drug that is now being tested as a potential treatment for COVID-19 in international, multi-site clinical trials. | 2020-04-07 |
| 32259123 | Where needed, clients are referred to 16-hour treatment clinics, which are specifically set up for the diagnosis and treatment of the disease, to the hospitals, or will be treated at home. | 2020-04-09 |
| 32259129 | Therefore, studies with a large sample size are required to determine the efficacy of metronidazole in the treatment of COVID-19 infection. | 2020-04-09 |
| 32259247 | Access to pain treatment has been called a fundamental human right by numerous organizations. | 2020-04-07 |
| 32259313 | As the incidence continues to rise at a rapid pace, critical care teams are faced with challenging treatment decisions. […] Urgent identification of potential treatment strategies is a priority. | 2020-04-07 |
| 32259477 | Thus, ferrets represent an infection and transmission animal model of COVID-19 that may facilitate development of SARS-CoV-2 therapeutics and vaccines. | 2020-04-10 |
| 32259899 | The only method to understand the clustering and the immediate hospital resource needs is mandatory, uniform, daily reporting of hospital censuses of COVID-19 cases admitted to hospital wards and intensive care units. | 2020-04-10 |
| 32264666 | Although several comorbidities such as hypertension, diabetes and cardiovascular diseases are defined as a risk factor for developing the acute respiratory syndrome and need for intensive care; immune-compromised situations such as rheumatic disease which require immunosuppressive treatment strikingly are not found to be a risk factor for more severe disease course. | 2020-04-08 |
| 32265310 | Limited pre-clinical data suggest that systemic MSC administration can significantly reduce respiratory virus (Influenza strains H5N1 and H9N2)-induced lung injury, however, there are no available data in models of coronavirus respiratory infection.There are a rapidly increasing number of clinical investigations of cell-based therapy approaches for COVID-19. | 2020-04-10 |
| 32265848 | This review was written for the topic of Antivirals for Emerging Viruses: Vaccines and Therapeutics in the Virology section of Frontiers in Microbiology. | 2020-04-10 |
| 32266381 | We describe correlations between laboratory parameters and treatment duration (r= -0.637; p=0.002) and time to virus recrudescence (r= 0.52; p=0.008) respectively, suggesting the need for additional measures to confirm illness resolution in COVID-19 patients. | 2020-04-08 |
| 32266708 | Cardiovascular diseases, in particular hypertension, as well as the cardiovascular treatment with Renin-Angiotensin System inhibitors such as Angiotensin Converting Enzyme (ACE) inhibitors and Angiotensin Receptor Blockers (ARBs), are claimed once again as mechanisms of Severe Acute Respiratory Syndrome (SARS) during the COVID-19 outbreak due to Cov-2 epidemics. | 2020-04-16 |
| 32266987 | To assess the efficacy of corticosteroid treatment of patients with coronavirus disease 2019 (COVID-19). […] Virus clearance time, length of hospital stay, and duration of symptoms, by treatment type (including or not including corticosteroid therapy). […] Eleven of 31 patients with COVID-19 received corticosteroid treatment. […] Cox proportional hazards regression analysis indicated no association between corticosteroid treatment and virus clearance time (hazard ratio [HR], 1.26; 95% CI, 0.58-2.74), hospital length of stay (HR, 0.77; 95% CI, 0.33-1.78), or duration of symptoms (HR, 0.86; 95% CI, 0.40-1.83). […] Corticosteroids are widely used when treating patients with COVID-19, but we found no association between therapy and outcomes in patients without acute respiratory distress syndrome. | 2020-04-08 |
| 32266994 | In addition, we would like to mention that amiloride, which increases the cytosolic pH, can be used in the COVID-19 treatment. | 2020-04-08 |
| 32267072 | Anakinra, a recombinant IL-1 receptor antagonist, has been used subcutaneously and intravenously in pediatric patients and is considered a first-line treatment for MAS and secondary HLH (sHLH) among many pediatric rheumatologists. […] Previous reports of anakinra used in adults for treatment of MAS or sHLH are limited to subcutaneous administration. | 2020-04-09 |
| 32267109 | In the absence of specific anti-viral molecules, treatment is currently mainly symptomatic. | 2020-04-09 |
| 32267139 | This axis might be a potential target for the treatment of brain metastasis of lung cancer. | 2020-04-09 |
| 32267556 | A number of novel and repurposed therapies agents with activity against SARS-CoV-2 have been identified and most institutions have developed clinical pathways to operationalize their use in appropriate COVID-19 patients.1-3 However, optimal drug therapy decisions for those with moderate to severe COVID-19 infections are extremely challenging at this time as evidence is limited. | 2020-04-08 |
| 32267560 | The main mechanism of ARDS is uncontrolled systemic inflammatory response and cytokine storm following release of proinflammatory cytokines (such as interferons (IFN), interleukines (IL), tumor necrosis factor (TNF)-α) and chemokines.2-3 So, some Chinese researchers proposed or used anti-inflammatory agents in the treatment regimen of patients with COVID-19.3-4. | 2020-04-08 |
| 32267566 | Based on the available evidence we believe that tetracyclines may be effective agents in the treatment of COVID-19. | 2020-04-08 |
| 32267771 | Here, we present the rationale and design of a large, international trial that combines features of adaptive platform trials with pragmatic point-of-care trials to determine best treatment strategies for patients admitted to an intensive care unit with severe community-acquired pneumonia (CAP). […] The trial randomizes patients to multiple interventions within 4 treatment domains: antibiotics, antiviral therapy for influenza, host immunomodulation with extended macrolide therapy, and alternative corticosteroid regimens, representing 240 treatment regimens. | 2020-04-09 |
| 32267987 | At present, there is no specific antiviral therapy for COVID-19 and the main treatments are supportive. | 2020-04-08 |
| 32267998 | There is evidence in both animals and humans that fibrinolytic therapy in Acute Lung Injury and ARDS improves survival, which also points to fibrin deposition in the pulmonary microvasculature as a contributory cause of ARDS and would be expected to be seen in patients with ARDS and concomitant diagnoses of DIC on their laboratory values such as what is observed in more than 70% of those who die of COVID-19 (8-10). | 2020-04-08 |
| 32268005 | Therapeutics are desperately needed to reduce the morbidity and mortality of this pandemic disease. […] It has been reported that hydroxychloroquine (HCQ) is active against SARS-CoV-2 in vitro, and this finding was quickly supported by an open label non-randomized clinical trial that provided the first published clinical evidence HCQ may be a treatment option. | 2020-04-11 |
| 32268018 | To analysis the medication characteristics of the prescriptions issued via open channel by the National and Provincial Health Committee and the State Administration of Traditional Chinese Medicine in treating coronavirus disease 2019 (COVID-19). […] We collected the data of traditional Chinese medicine related to treatment plans published by the National and Provincial Health Committee and the State Administration of Traditional Chinese Medicine from the start of COVID-19 outbreak in Wuhan to February 19, 2020. […] The study collected 4 national and 34 regional prevention and treatment plans, 578 items, 84 traditional Chinese formulations, 60 Chinese patent medicines, and 230 Chinese herbs. […] The main medication characteristics are clearing heat, entilating lung, removing toxicity and removing turbidity. | 2020-04-10 |
| 32268019 | We applied HFNC for oxygen therapy in severe and critical COVID-19 patients and summarized the following experiences. […] Thirdly, to avoid hypoxia or hypoxemia, the treatment goal of HFNC should be maintained the oxygen saturation (SpO2) above 95% for patients without chronic pulmonary disease. […] Finally, patients should wear a surgical mask during HFNC treatment to reduce the risk of virus transmission through droplets or aerosols. | 2020-04-10 |
| 32268454 | Objective: To introduce Treatment experience of burn patients combined with inhalation injury during epidemic period of Corona Virus Disease 2019 (COVID-19). Methods: Six burn patients combined with inhalation injury were hospitalized in Department of Burns of Tongren Hospital of Wuhan University& Wuhan Third Hospital from February 1 to March 1 in 2020duringhigh-incidence period of COVID-19, including 4 males and 2 females, aged 21-63 years, hospitalized for 2-4 hours, with total burn areas of 1%-20% TBSA and full-thickness burn areas of 1%-12% TBSA. […] After admission, 6 patients were given routine treatment, the medical staffs paid attention to the protection and screened COVID-19 according to the diagnosis and treatment plan of COVID-19. […] After treatment for 14-32 days, 6 patients were cured and discharged. Conclusions: During the novel coronavirus, burn patients combined with inhalation injury should be treated under condition of good protection for COVID-19 among doctors and nurses. | 2020-04-08 |
| 32268515 | Finally, we focused on the genes in the network that are already associated with known drugs and evaluated their role for a potential treatment of Covid-19. […] Among possible interesting drugs for Covid-19 treatment, we found Nimesulide, Fluticasone Propionate, Thiabendazole, Photofrin, Didanosine and Flutamide. | 2020-04-13 |
| 32268641 | This guideline is applicable to the health protection requirements of large indoor stadiums which are reconstructed as treatment sites for COVID-19 patients with mild symptoms during the outbreak. | 2020-04-10 |
| 32268719 | Severe COVID-19 illness is characterised by the development of Acute Respiratory Distress Syndrome (ARDS), for which the mainstay of treatment is represented by mechanical ventilation. | 2020-04-10 |
| 32268923 | The virus first appeared in Wuhan, China, in late December 2019, and traditional Chinese herbal medicine is being used for its treatment. […] The use of traditional Chinese herbal medicine for treatment or prevention of these novel viral infections affecting the pneumonia will be investigated. | 2020-04-14 |
| 32269087 | Supportive treatment was provided for all 4 newborn babies. | 2020-04-11 |
| 32269597 | He was undergoing chemotherapy and had just returned to Nigeria following medical treatment in the United Kingdom. | 2020-04-11 |
| 32269598 | This is of particular interest in oncology since patients receiving some cancer treatments such as chemotherapy or immune therapy often experience similar symptoms as side-effects. […] Whilst more data is currently needed to strengthen our knowledge of the symptoms of COVID-19, oncology patients who are concerned about anosmia or ageusia in the context of their systemic anti-cancer therapy should contact their acute oncology support line for advice. | 2020-04-09 |
| 32269893 | The penultimate portion of the review aims to explain the involvement of micronutrients such as vitamin C and vitamin D in COVID19 treatment and prophylaxis. | 2020-04-11 |
| 32270359 | We would like to share our experience and send a clear message to keep a high attention on stroke as an emergency condition, because we have observed a decreased number of patients with minor strokes and TIAs, longer onset-to-door and door-to-treatment times for major strokes, and a reduced number of transfers from spokes. | 2020-04-11 |
| 32270371 | To date, there is no specific therapy for COVID-19. | 2020-04-09 |
| 32270515 | He received antiviral treatment plus recombinant human Erythropoietin(rhEPO) due to his severe anemia. […] After 7 days of treatment, he was discharged with miraculous improvement in his symptoms and hemoglobin level. | 2020-04-09 |
| 32270592 | Five (50.0%) patients received antiviral treatment. | 2020-04-09 |
| 32271376 | When comparing patients with early (<15 days) and late viral RNA clearance (≥15 days after illness onset), prolonged SARS-CoV-2 RNA shedding was associated with male sex (p=0.009), old age (p=0.033), concomitated with hypertension (p=0.009), delayed admission to hospital after illness onset (p=0.001), severe illness at admission (p=0.049), invasive mechanical ventilation (p=0.006), and corticosteroid treatment (p=0.025). | 2020-04-09 |
| 32271454 | Employing combined therapy of modern medicine and traditional Chinese medicine has been proposed, in which Ma Xing Shi Gan Decoction (MXSGD) was recommended as a basic prescription and applied widely in the clinical treatment of COVID-19. | 2020-04-15 |
| 32271455 | The treatment of severe COVID-19 patients has been rarely reported. | 2020-04-15 |
| 32271456 | Both groups achieved good therapeutic effect with the body temperature of patients decreased gradually from admission to the 10th day of treatment. […] The number of days for nCoV-RNA turning negative after treatment was significantly decreased in the test group than that in the control group. […] Compared with the treatment of pneumonia-associated adjuvant drugs alone, the combination treatment with LPV/r and adjuvant drugs has a more evident therapeutic effect in lowering the body temperature and restoring normal physiological mechanisms with no evident toxic and side effects. […] In view of these conclusions, we suggested that the use of LPV/r combined with pneumonia-associated adjuvant drugs in the clinical treatment for patients with COVID-19 should be promoted. | 2020-04-15 |
| 32271458 | The status of the infected cases can be determined basing on the treatment process along with several other factors. | 2020-04-15 |
| 32271459 | A retrospective analysis was performed on the confirmed cases of COVID-19, who were admitted to the North Hospital of Changsha first Hospital (Changsha Public Health treatment Center) from January 17 to February 7, 2020. | 2020-04-15 |
| 32271490 | Practical suggestions regarding evaluation and treatment will be provided, realizing that there may be constraints on medical resources and the nature of this pandemic remains dynamic. | 2020-04-09 |
| 32271599 | One of the groups that is considered high risk in this pandemic are cancer patients as they are treated with a variety of immune system suppressor treatment modalities and this puts them in a great risk for infectious disease (including COVID-19). […] This article provides the recommendations and possible actions that should be considered by patients, their caregivers and families, physician, nurses, managers and staff of medical centers involved in cancer diagnosis and treatment. […] We pursued two major goals in our recommendations: first, limiting the exposure of cancer patients to medical environments and second, modifying the treatment modalities in a manner that reduces the probability of myelosuppression such as delaying elective diagnostic and therapeutic services, shortening the treatment course, or prolonging the interval between treatment courses. | 2020-04-14 |
| 32271601 | Since there is no specific drug for COVID-19, the treatment is mainly symptomatic supportive therapy. […] In addition, it should be pointed out that patients with severe illness need more aggressive treatment and meticulous care. | 2020-04-14 |
| 32272173 | The conserved nature of the fusion domain and mechanism across the CoV family make it a valuable target to elucidate and develop pan-CoV therapeutics. | 2020-04-09 |
| 32272396 | Since the outbreak of COVID-19, international attention has raised to develop treatment and control options such as types of immunotherapies. | 2020-04-15 |
| 32272481 | Currently there are no targeted therapeutics and effective treatment options remain very limited. | 2020-04-09 |
| 32272630 | His condition deteriorated initially, but eventually improved with supportive treatment and the compassionate use of antivirals and antimalarials and is now in a stable condition. | 2020-04-10 |
| 32272857 | Impact statement Given the steep mortality caused by the recent novel coronavirus (COVID-19) pandemic, there is clear need for advances in diagnostics and therapeutics for viral outbreaks. | 2020-04-15 |
| 32273253 | Hospital pharmacists shall support pharmaceutical care services by participating in making evidence-based decisions for medication, monitoring and evaluation of medication safety and efficacy, providing strengthened care for special population and patients with combined underlying diseases, monitoring and management of convalescent plasma therapy, providing emotional counselling and psychological support, and providing scientific information about COVID-19 vaccines. | 2020-04-13 |
| 32273489 | Computed tomography (CT) manifestations and treatment of children with COVID-19 are still unclear. | 2020-04-10 |
| 32273490 | This review additionally considers COVID-19 in immunosuppressed children, and also suggests a management algorithm for the few children who appear to present with life threatening infection, including the potential use of antiviral and immunomodulatory treatment. | 2020-04-10 |
| 32274341 | In this review, we highlight these important issues based on the recent developments in the field, for optimizing the management and treatment of liver injury in Chinese patients with COVID-19. | 2020-04-13 |
| 32274342 | Based on the current evidence from case reports and case series, this review article focuses on the demographic and clinical characteristics, potential mechanisms, and treatment options for COVID-19-related liver dysfunction. | 2020-04-13 |
| 32274630 | Here, we provide a framework for institutions and governments to help adjudicate treatment allocations to patients with neuro-oncologic disease. | 2020-04-13 |
| 32274772 | Corticosteroid use is a mainstay of therapy for those women delivering prematurely. […] · Corticosteroid use is an important part of prematurity treatment because it provides benefit to the fetus.. | 2020-04-10 |
| 32274773 | In about 20% of patients, severe symptoms occur after a mean incubation period of 5 - 6 days; 5% of patients need intensive care therapy. […] Therapy is based on established recommendations issued for patients with acute lung injury (ARDS). […] Lung protective ventilation, prone position, restrictive fluid management and an adequate management of organ failures are the mainstays of therapy. | 2020-04-13 |
| 32274774 | The general treatment principles in dealing with COVID-19 patients and the recommendations for action in intensive care therapy also apply to pregnant and postpartum patients. | 2020-04-13 |
| 32275128 | To analyze the roles of multidisciplinary team (MDT) in the diagnosis and treatment of suspected cases of corona virus disease 2019 (COVID-19). […] With the guidance of MDT, one COVID-19 patient was transferred to designated provincial hospital after effective treatment; one patient complicated with acute cholecystitis underwent gallbladder puncture and drainage; and COVID-19 was excluded in a highly suspected patient after alveolar lavage fluid examination. […] The efficiency of diagnosis and treatment for suspected COVID-19 patients can be improved under MDT mode, particularly for complicated and refractory cases. | 2020-04-13 |
| 32275256 | However, no specific drug has been previously approved for the COVID-19 treatment. […] The Lombardy Section of the Italian Society of Infectious and Tropical Diseases provided this «vademecum» with the aim to explore the current evidence about the drugs likely to be efficacious in the treatment of COVID-19. […] Lastly, a collaborating group with immunologists and rheumatologists has been built with the aim of providing some guidance about the use of tocilizumab, a promising option for the treatment of the hyperinflammatory state occurring in most patients affected by COVID-19. | 2020-04-15 |
| 32275257 | Radiological and serological methods are the most preferred among the other methods and the radiological method is the most preferred one which can diagnose the infection quickly and accurately with fewer false-negatives, that can be effective in protecting the patient’s life by initiating treatment and preventing the transmission of infection to other people. | 2020-04-15 |
| 32275295 | Rates of laboratory-confirmed COVID-19 infections (defined as the number of cases per day per million people), across age, sex, and geographic locations were calculated across 5 periods: December 8 to January 9 (no intervention), January 10 to 22 (massive human movement due to the Chinese New Year holiday), January 23 to February 1 (cordons sanitaire, traffic restriction and home quarantine), February 2 to 16 (centralized quarantine and treatment), and February 17 to March 8 (universal symptom survey). | 2020-04-14 |
| 32275452 | We compared the clinical characteristics, laboratory examinations, CT images and treatment of COVID-19 patients from three different cities in China. 476 patients were recruited from Jan 1 to Feb 15, 2020 at three hospitals in Wuhan, Shanghai and Anhui. […] Patients were divided into four groups according to age and into three groups (moderate, severe, and critical group) according to the fifth version of the guidelines issued by the National Health Commission of China on Diagnosis and Treatment of COVID-19. | 2020-04-10 |
| 32275463 | Anesthesiology specialists and residents who perform emergency operations on these patients in settings other than intensive care units should follow simple and easy-to-understand algorithms to ensure safety. | 2020-04-10 |
| 32275497 | Contamination was greater in intensive care units than general wards. | 2020-04-10 |
| 32275740 | The ILROG guidelines for using radiation therapy in hematological malignancies are widely used in many countries. […] The emergency situation created by the COVID-19 pandemic may result in limitations of treatment resources. […] Furthermore, in recognition of the need to also reduce the exposure of patients and staff to potential infection with COVID-19, the ILROG task force has made recommendations for alternative radiation treatment schemes. | 2020-04-10 |
| 32275753 | Levels of their lung lesions, oxygen saturation and heart rates were compared before and after treatment by CT scanning images and patient monitor. | 2020-04-10 |
| 32275775 | Entire hospitals have been converted into intensive care units, retired anesthesiologists have been called back to work, and specialists in other branches have been assigned to assist COVID-19 patients. | 2020-04-10 |
| 32275784 | Telemedicine, defined as the delivery of health care services at a distance using electronic means for diagnosis and treatment, holds tremendous promise to increase access to broadly specialty care. | 2020-04-10 |
| 32275805 | The study exposes the tension between a healthcare worker’s right to protection and a duty to provide treatment. | 2020-04-10 |
| 32275812 | Patients received a 10-day course of remdesivir, consisting of 200 mg administered intravenously on day 1, followed by 100 mg daily for the remaining 9 days of treatment. […] Of the 61 patients who received at least one dose of remdesivir, data from 8 could not be analyzed (including 7 patients with no post-treatment data and 1 with a dosing error). […] Measurement of efficacy will require ongoing randomized, placebo-controlled trials of remdesivir therapy. | 2020-04-10 |
| 32275914 | In this review, we discuss preliminary data concerning the potential activity of type 1 interferons on SARS-CoV-2, and the relevance of evaluating these molecules in clinical trials for the treatment of COVID-19. | 2020-04-16 |
| 32276097 | Ageing adults (65+) with disability are especially vulnerable to COVID-19 and upon contracting, are a cohort most likely to require palliative care. […] Therefore, it is very important that health services - particularly health services providing palliative care - are proximately available. […] The geographic dispersion of areas with people vulnerable to COVID-19 with poor access to palliative care and health services are clarified. […] The spatial methodology employed can be implemented in different contexts to support evidence-based COVID-19 and pandemic palliative care service decisions. | 2020-04-13 |
| 32276099 | Palliative care teams who practice in the community setting are faced with a difficult task: How do we actively triage the most urgent visits while keeping our vulnerable patients safe from the pandemic? […] The following are recommendations created by the Palo Alto Medical Foundation Palliative Care and Support Services team to help triage and coordinate for timely, safe, and effective palliative care in the community and outpatient setting during the ongoing COVID-19 pandemic. […] We recommend active triaging, communication, frequent screening for COVID-19 symptoms for palliative care patients been evaluated in the community setting. […] An understanding of infection risk, mutual consent between designated providers, patients, and their families are crucial to maintaining safety while delivering community-based palliative care during the COVID-19 pandemic. | 2020-04-12 |
| 32276102 | While palliative care specialists have training in these skills, many front-line clinicians from other specialties do not. | 2020-04-13 |
| 32276137 | While specific treatment is not yet coming soon, individual risk assessment and management strategies are crucial. | 2020-04-13 |
| 32276140 | In this report we suggest that patients with systemic lupus erythematous might be especially prone to severe COVID-19 independent of their immunosuppressed state from lupus treatment. […] Epigenetic control of the ACE2 gene might be a target for prevention and therapy in COVID-19. | 2020-04-13 |
| 32276848 | Epidemiological, clinical, laboratory, and radiological characteristics and treatment data were collected. | 2020-04-14 |
| 32276929 | The modulation of its expression by sex steroids could contribute to the male predominance of severe infections and given that TMPRSS2 has no known indispensable functions, and inhibitors are available, it is an appealing target for prevention or treatment of respiratory viral infections. | 2020-04-11 |
| 32276930 | Amid concerns over the spread of COVID-19, oncology practices have “gone virtual,” with video appointments scheduled for any service that does not require diagnostic testing or treatment. | 2020-04-11 |
| 32277040 | The structure provides a basis for the design of new antiviral therapeutics targeting viral RdRp. | 2020-04-11 |
| 32277065 | The nucleotide analogue remdesivir is an investigational drug for the treatment of human coronavirus infection. | 2020-04-13 |
| 32277351 | The outbreak of COVID-19 affects the management of these chronic conditions, not only for those who are already receiving treatment but also for those who are about to start a new treatment to control their disease. | 2020-04-11 |
| 32277367 | Current international society recommendations suggest that patients with rheumatic diseases on immunosuppressive therapy should not stop glucocorticoids during COVID-19 infection, although minimum possible doses may be used. | 2020-04-11 |
| 32277387 | It is urgent to set up guidelines for the prevention, diagnosis, and treatment of COVID-19 in liver transplant recipients. | 2020-04-11 |
| 32277408 | After receiving antiviral therapy and mechanical life support, Trop I was reduced to 0.10 g/L, and interleukin-6 was reduced to 7.63 pg/mL. | 2020-04-11 |
| 32277490 | This means that, also during this pandemic, fetal anomalies will be detected, and that discussions regarding invasive genetic testing and possibly fetal therapy will need to take place. | 2020-04-11 |
| 32277555 | This case states the importance of close monitoring of the concentration of ciclosporin in patients treated with lopinavir/ritonavir, routine treatment of corticosteroid can be continued. […] Further data are needed to achieve better understanding of the impact of immunosuppressive therapy on the clinical presentation, severity and outcome of SARS-CoV-2 infections in solid organ transplant recipients. | 2020-04-11 |
| 32277967 | Monitoring dynamic changes of SAA, combined with CT imaging could be valuable in diagnosis and treatment of COVID-19. | 2020-04-14 |
| 32278065 | Current treatment is supportive, but several options appear promising and are the subject of investigation. | 2020-04-13 |
| 32278097 | This study aimed to synthesise evidence for the role and response of palliative care and hospice teams to viral epi/pandemics, to inform the COVID-19 pandemic response. | 2020-04-13 |
| 32278175 | Hence, the recent outburst of COVID-19 highlights an urgent need for therapeutics targeting SARS-CoV-2. […] Further, the current treatment options, drugs available, ongoing trials and recent diagnostics for COVID-19 have been discussed. | 2020-04-16 |
| 32278693 | Precautionary measures remain the sole obliging tactic to cease the person to person transmissions till any effective method of treatment or vaccine is developed. […] Along with these, Methisazone an inhibitor of protein synthesis, CGP42112A an angiotensin AT2 receptor agonist and ABT450 an inhibitor of the non-structural protein 3-4A might become convenient treatment option as well against COVID-19. […] The drug repurposing approach provide an insight about the therapeutics that might be helpful in treating corona virus disease. | 2020-04-12 |
| 32278716 | The aim of these “crisis-driven” recommendations is (1) to ensure appropriate and timely treatment of SHD patients, (2) to minimize the risk of COVID-19 exposure to patients and healthcare workers, and (3) to limit resource utilization under conditions of constraint. | 2020-04-12 |
| 32278725 | Surgical treatment of non-COVID-19 related disease during this period, however, still remains necessary. | 2020-04-16 |
| 32278764 | We searched for articles in PubMed and Google Scholar databases till 02 April 2020, with the following keywords: “SARS-CoV-2”, “COVID-19”, “infection”, “pathogenesis”, “incubation period”, “transmission”, “clinical features”, “diagnosis”, “treatment”, “diabetes”, with interposition of the Boolean operator “AND”. | 2020-04-16 |
| 32278766 | Clinical pharmacists’ routine task is carrying out pharmaceutical care to ensure patients’ safe and reasonable medication use. […] Facing public health emergencies, clinical pharmacists can give full play to their professional expertise, analyze the current situation rationally, formulate telehealth strategies swiftly, and work in a united and efficient manner to provide innovative pharmacy services to ensure medication safety and rational use of medicine. | 2020-04-12 |
| 32278811 | Given the extreme importance of the current pandemic caused by COVID-19, and due to the fact that scientists agree that there is no identified pharmacological treatment where possible therapeutic alternatives are raised through drug repositioning. […] We present a selection of studies involving drugs from different pharmaceutical classes with activity against SARS-CoV-2 and SARS-Cov, with potential use in the treatment of COVID-19 disease. | 2020-04-12 |
| 32278865 | Since the beginning of COVID-19 epidemic, we shifted all PAD patients to home therapy, and activated remote visits. […] Health-Related-Quality of Life was similar in patients forced to shift from hospital-based to home-based immunoglobulin treatment and in patients who continued their usual home-based replacement. | 2020-04-12 |
| 32278932 | The emergence of the COVID-19 pandemic has severely affected medical treatment protocols throughout the world. | 2020-04-12 |
| 32279346 | In patients with COIVD-19, in the early aggravation phase before treatment, observation of peripheral blood film shows the presence of pronounced morhological anomalies of the granulocyte series. […] One week after the start of treatment, such anomalies subside, and an increasing proportion of reactive lymphocytes dominates. | 2020-04-12 |
| 32279418 | During the novel coronavirus pandemic, organ transplant recipients represent a frail susceptible category due to long-term immunosuppressive therapy. […] For this reason, clinical manifestations may differ from general population and different treatment approaches may be needed. […] The patient was left with steroid therapy alone. […] We stress the need for guidelines in transplant recipients with COVID-19 infection with particular regard to the management of therapy. | 2020-04-12 |
| 32279469 | There is currently no robust evidence to support prescribing hydroxychloroquine as a treatment or prophylaxis for COVID-19. | 2020-04-13 |
| 32280433 | Due to the lack of effective treatment options for SARS-CoV-2, various strategies are being tested in China, including drug repurposing. […] The result showed that atazanavir, an antiretroviral medication used to treat and prevent the human immunodeficiency virus (HIV), is the best chemical compound, showing an inhibitory potency with Kd of 94.94 nM against the SARS-CoV-2 3C-like proteinase, followed by remdesivir (113.13 nM), efavirenz (199.17 nM), ritonavir (204.05 nM), and dolutegravir (336.91 nM). […] In addition, we also found that several antiviral agents, such as Kaletra (lopinavir/ritonavir), could be used for the treatment of SARS-CoV-2. […] Overall, we suggest that the list of antiviral drugs identified by the MT-DTI model should be considered, when establishing effective treatment strategies for SARS-CoV-2. | 2020-04-16 |
| 32281052 | However, no standard treatment for this disease has been discovered to date. […] Probably, preventing the severe acute respiratory infection form of COVID-19 as the most dangerous phase of this disease can be helpful for the treatment and reduction of the death rate. […] In this regard, mesenchymal stem cells (MSCs)-based immunomodulation treatment has been proposed as a suitable therapeutic approach and several clinical trials have begun. […] Given the uncertainties in this area, we reviewed reported clinical trials and hypotheses to provide useful information to researchers and those interested in stem cell therapy. […] In this study, we considered this new approach to improve patient’s immunological responses to COVID-19 using MSCs and discussed the aspects of this proposed treatment. […] However, currently, there are no approved MSC-based approaches for the prevention and/or treatment of COVID-19 patients but clinical trials ongoing. | 2020-04-13 |
| 32281114 | A case of late initiation of remdesivir antiviral therapy in the successful treatment of a patient with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in a mixed medical ICU of a community teaching hospital is presented. | 2020-04-13 |
| 32281214 | Aside from the pulmonary manifestations of disease, there are likely to be several electrophysiologic (EP) sequelae of COVID-19 infection and its treatment, due to consequences of myocarditis and the use of QT-prolonging drugs. | 2020-04-13 |
| 32281317 | Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus-2 not yet has established its treatment, but convalescent plasma has been expected to increase survival rates as in the case with other emerging viral infections. […] To our knowledge, this is the first report of the use of convalescent plasma therapy for COVID-19 in Korea. | 2020-04-15 |
| 32281327 | Currently, there is no specific drug or vaccine besides symptomatic supportive therapy. […] In view of the high homology between the gene sequences of the novel coronavirus and SARS virus, and the similarities between the two in terms of pathogenic mechanism and clinical manifestations, our team established a rapid screening and optimization model for the prevention and treatment of the novel coronavirus based on clinical experience and molecular docking technology. […] This provides evidence for the scientific and potential efficacy of the TCM prescription from the perspective of treatment target analysis, and also suggests that the TCM prescription has the potential to directly inhibit viral infection in addition to improving clinical symptoms or syndromes. […] Based on this, our team optimized and formed a new anti-coronavirus TCM prescription "Keguan Yihao", immediately providing the TCM prescription with certain clinical experience and objective evidence support for the prevention and treatment of new emergent infectious diseases in our hospital. […] The TCM prescription was combined with modern medicine symptomatic supportive treatment for clinical treatment, preliminary results showed better effect than symptomatic supportive therapy alone. | 2020-04-14 |
| 32281328 | This study established optimization docking models and virtual screening to discovery potential active herbs for the prevention and treatment of the novel coronavirus based on molecular docking technology. […] By combining the diagnosis and treatment scheme of Hunan province’s and angiotensin converting enzyme 2(ACE2) inhibitors screening from literature, present study also discussed the rational application of candidate herbs to this epidemic situation. | 2020-04-14 |
| 32281329 | In the end, we obtained the potential active prescriptions on "cytokine storm" according to the potential herbs in the "National novel coronavirus pneumonia diagnosis and treatment plan(trial version sixth)". | 2020-04-14 |
| 32281330 | To analyze the registered clinical trial protocols of traditional Chinese medicine(TCM) for the prevention and treatment of coronavirus disease 2019(COVID-19), in order to provide information for improving the quality of research design. […] There was a quick response of clinical research on the prevention and treatment of COVID-19 with TCM, with the current registered protocols covers the whole process of disease prevention, treatment and rehabilitation. | 2020-04-14 |
| 32281331 | To investigate the regularity of prescription and clinical syndromes by analyzing the diagnosis and treatment protocols of traditional Chinese medicine(TCM) for coronavirus disease 2019(COVID-19), so as to provide references for syndrome differentiation and relevant researches. […] The diagnosis and treatment protocols of COVID-19 published by national and regional health authorities were searched, and information was extracted in regard to disease stages, type of syndromes, and prescriptions, etc. […] A total of 26 diagnosis and treatment protocols of TCM for COVID-19 were retrieved after screening(including 1 national scheme and 25 regional ones), among which 16 contained aspects of both prevention and treatment, 7 only involved treatment contents and 3 were prevention schemes. […] There were many diagnosis and treatment protocols for COVID-19 have been published, which generally followed the national edition, through with certain personalities in different regional protocols. […] There were common features with respect to the disease stage, syndrome differentiation, therapeutic principles and methods, as well as prescriptions; the treatment were generally carried out against the core pathogenesis and progress of the disease. […] Along with the deepening recognition of COVID-19, the diagnosis and treatment protocols are still need further concretization and standardization. […] We hope researchers and decision-makers can pay more attention to the treatment of Huayu Tongluo in severe and recovery period. | 2020-04-14 |
| 32281332 | From the medicinal properties to high-frequency drugs and new prescriptions, it could be seen that the overall treatment of COVID-19 by traditional Chinese medicine was to strengthen body resistance, eliminate pathogenic factors, and give attention to Qi and Yin. | 2020-04-14 |
| 32281333 | This study collected prevention and treatment approaches of traditional Chinese medicine for COVID-19 released from the National Health Committee of China, 7 provinces and municipal health committees, the Chinese Medicine Administration and Handbook of Traditional Chinese Medicine Diagnosis and Treatment of COVID-19 between January 1 and February 18, 2020, and prescriptions prepared by 3 masters of Chinese medicine and 4 well-known Chinese medicine experts. […] These information were selected according to the inclusion and exclusion criteria, and EpiData 3.0 software was used to establish the "Traditional Chinese Medicine Prescription Library for the Prevention and Treatment of COVID-19" and the "Common Database of Traditional Chinese Medicine for the Prevention and Treatment of COVID-19". […] Staged medication and local conditions need attention during the identification and treatment of COVID-19 clinical syndromes. | 2020-04-14 |
| 32281334 | Traditional Chinese medicine(TCM) has been recommended for the treatment of COVID-19 in Novel Coronavirus Pneumonia Prevention and Control Strategy, which have made outstanding contributions to the prevention and control of the epidemic. […] The wide application of Chinese medicine asked the pharmacists and doctors, nurses, and medical technicians in Wuhan and around the country to stand on the front line of COVID-19 treatment, and provide pharmaceutical care services, which has effectively guaranteed the safety and rational use of Chinese medicine. […] This article will introduce the TCM cognition of the COVID-19, analyze the clinical application of Chinese medicine and the entry point of pharmaceutical care, and clarify that clinical Chinese pharmacists can participate in making medication therapy plan, medication reconciliation, and prescription review, promoting rational drug use, pharmaceutical monitoring, and drug risk management. […] The participation of clinical Chinese pharmacists in the prevention and treatment of COVID-19 is conducive to improving the level of rational use of TCM, by ensuring the effectiveness, and safety. | 2020-04-14 |
| 32281335 | However, there have not been any effective drugs for treatment, with symptomatic treatment and prevention prevailing. […] The treatment plans of severe acute respiratory syndrome(SARS) and Middle East respiratory syndrome(MERS) are often used for reference in clinic. […] The advantages of traditional Chinese medicine(TCM) in treating SARS and MERS are that it can intervene and block the progression of disease in early stage, significantly reduce symptoms, shorten the treatment duration of patients, reduce complications and side effects caused by hormone therapy. […] Chinese patent medicines and prescriptions in medical observation and clinical treatment were recommended in the "pneumonia diagnosis and treatment plan for new coronavirus infection"(trial version fifth) of the National Health Commission of the People’s Republic of China. […] Qingfei Paidu Decotion was recommended for the treatment of COVID-19 by the National Health Commission of the People’s Republic of China and National Administration of Traditional Chinese Medicine. […] TCM shows good clinical efficacy and great potential in the treatment of COVID-19. […] In this paper, we reviewed traditional Chinese medicines and its active ingredients in the hope of bringing novel inspirations to the drug screening and clinical treatment for COVID-19. | 2020-04-14 |
| 32281481 | This study provides information on the main toxicological and epidemiological aspects to be considered for prophylaxis or treatment of COVID-19 using CQ but mainly HCQ, which is a less toxic derivative than CQ, and was shown to produce better results in inhibiting proliferation of SARS-CoV-2 based upon preliminary tests. | 2020-04-16 |
| 32281667 | " 1 which report the clinical features, diagnosis and treatment of the novel Coronavirus Disease 2019 (COVID-19). | 2020-04-13 |
| 32281674 | Mucosa exposure and inappropriate treatment of medical and non-medical articles used by the patients all could increase the risks of COVID-19 transmission. | 2020-04-13 |
| 32281695 | Based on the idea of host-directed therapy (HDT), we performed a negative co-expression analysis using big data of 60 000 Affymetrix expression arrays and 5000 TCGA data sets to determine the functions of TAS2R10, which can be activated by numerous bitter substances. […] To quickly guide the clinical treatment of 2019-nCoV, we searched currently available drugs that are agonists of TAS2Rs. | 2020-04-13 |
| 32281757 | However, as Covid-19 is an emerging disease, more work is needed to improve prevention, diagnosis and treatment strategies. […] It is essential to avoid nosocomial spread; in order to control and reduce the rate of infections it is necessary to strengthen the management of medical and nursing personnel through the early diagnosis, isolation and treatment of patients undergoing dialysis treatment. […] We cover here a series of recommendations for the treatment of dialysis patients who are negative to the virus, and of those who are suspected or confirmed positive. | 2020-04-16 |
| 32282022 | The pandemic of coronavirus disease 2019 (COVID-19) caused by the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) presents an unprecedented challenge to identify effective drugs for prevention and treatment. […] The most promising therapy is remdesivir. | 2020-04-13 |
| 32282359 | Large numbers of people are predicted to become critically ill with acute respiratory distress syndrome (ARDS) and will require management in intensive care units (ICUs). | 2020-04-13 |
| 32282372 | Here he considers the implications of exemplary innovations-virtual care, hospital at home, advances in diagnosis and therapy, virtual learning, and virtual clinical learning-for regulators, academic medical centers, faculty, and students. | 2020-04-13 |
| 32282502 | No established treatment is currently available; however, several therapies, including remdesivir, hydroxychloroquine and chloroquine, and interleukin (IL)-6 inhibitors, are being used off-label and evaluated in ongoing clinical trials. | 2020-04-13 |
| 32282614 | The pandemic of coronavirus disease 2019 (COVID-19) has unique implications for the anesthetic management of endovascular therapy for acute ischemic stroke. […] The Society for Neuroscience in Anesthesiology and Critical Care appointed a task force to provide timely, consensus-based expert recommendations using available evidence for the safe and effective anesthetic management of endovascular therapy for acute ischemic stroke during the COVID-19 pandemic. | 2020-04-13 |
| 32282863 | In this minireview, we provide a brief introduction of the general features of SARS-CoV-2 and discuss current knowledge of molecular immune pathogenesis, diagnosis and treatment of COVID-19 on the base of the present understanding of SARS-CoV and MERS-CoV infections, which may be helpful in offering novel insights and potential therapeutic targets for combating the SARS-CoV-2 infection. | 2020-04-16 |
| 32282974 | State-run hospitals and clinics are already overstressed by continuous demand for treatment of vector-borne diseases and community-acquired infections as well as high rates of non-communicable diseases. […] As ethical expertise in Latin America focuses on research ethics, few hospitals in the region have functioning clinical ethics committees or clinical ethics policy, forcing healthcare personnel to make excruciating treatment decisions in an environment dominated by material scarcity and public distrust. | 2020-04-14 |
| 32282986 | Following a treatment regimen consisting of discontinued immunosuppressant use and low-dose methylprednisolone-based therapy, the patient developed acute rejection but eventually recovered. […] His treatment regimen consisted of reduced immunosuppressant use. | 2020-04-13 |
| 32282991 | We report a case of a 32-year-old KTR who developed SARS-CoV-2 infection and fully recovered in 15 days while maintaining standard immunosuppressive therapy. | 2020-04-13 |
| 32282993 | We would like to thank the authors for their insightful thoughts on the consideration of anticoagulants and treatment for haemophilia A and B during the COVID-19 pandemic. | 2020-04-13 |
| 32283108 | Viral RNA-dependent RNA polymerases (RdRp) play essential roles in viral RNA synthesis, and thus remains the target of choice for the prophylactic or curative treatment of several viral diseases, due to high sequence and structural conservation. […] To date, the most promising broad-spectrum class of viral RdRp inhibitors are nucleoside analogues (NAs), with over 25 approved for the treatment of several medically important viral diseases. | 2020-04-16 |
| 32283143 | The cycle threshold values of open reading frame 1ab and nucleocapsid genes by RT-PCR assay were monitored during antiviral therapy. | 2020-04-13 |
| 32283144 | An outbreak of novel coronavirus in 2019 threatens the health of people, and there is no proven pharmacological treatment. […] The result indicated that critical patients were more likely to require corticosteroids therapy (risk ratio [RR]=1.56, 95% confidence interval [CI]=1.28-1.90, P<0.001). […] However, corticosteroid treatment was associated with higher mortality (RR=2.11, 95%CI=1.13-3.94, P=0.019), longer length of stay (weighted mean difference [WMD]=6.31, 95%CI=5.26-7.37, P<0.001), a higher rate of bacterial infection (RR=2.08, 95%CI=1.54-2.81, P<0.001), and hypokalemia (RR=2.21, 95%CI=1.07-4.55, P=0.032) but not hyperglycemia (RR=1.37, 95%CI=0.68-2.76, P=0.376) or hypocalcemia (RR=1.35, 95%CI=0.77-2.37, P=0.302). | 2020-04-13 |
| 32283152 | This article reviews the occurrence mechanism and treatment strategies of the COVID-19 virus-induced inflammatory storm in attempt to provide valuable medication guidance for clinical treatment. | 2020-04-13 |
| 32283185 | There were somewhat lower rates chronic GVHD (HR=0.78, 0.61-0.99, p=0.04) and DFS (HR for treatment failure=1.19, 95%CI=1.01-1.29, p=0.04) with graft cryopreservation that were of marginal statistical significance after adjusting for multiple comparisons. | 2020-04-13 |
| 32283217 | The first chest X-ray (faint bilateral patchy opacities) and CT scan (some faint subpleural ground-glass opacities associated with pleural thickening) were not typical for initial COVID-19 pulmonary infection, however, the treatment for COVID-19 was started. | 2020-04-16 |
| 32283219 | As COVID-19 cases increase throughout the country and healthcare systems grapple with the need to decrease provider exposure and minimize personal protective equipment (PPE) use while maintaining high quality patient care, our specialty is called upon to consider new methods of delivering inpatient palliative care. […] Telepalliative medicine has been used to great effect in outpatient and home-based palliative care, but has had fewer applications in the inpatient setting. […] We describe our rapid and ongoing implementation of telepalliative medicine consultation for our inpatient palliative care teams and discuss lessons learned and recommendations for programs considering similar care models. | 2020-04-16 |
| 32283220 | As palliative care and other health care providers become overwhelmed with patients critically ill with COVID-19, and routine care becomes delayed, we have a charge to recognize and work with family caregivers. | 2020-04-14 |
| 32283324 | Since severe complications in adults are frequently caused by uncontrolled immune responses and a resulting “cytokine storm” that may be controlled by targeted blockade of cytokines, previously established treatment with immunosuppressive treatments may indeed protect children from complications. | 2020-04-16 |
| 32283325 | We aimed to clarify the features of COVID-19-related liver damage to provide references for clinical treatment. | 2020-04-13 |
| 32283815 | At the moment, there is no specific antiviral treatment recommended for the COVID-19 pandemic and the therapeutic strategies to deal with the infection are only supportive. | 2020-04-15 |
| 32284379 | In sum, we demonstrate the importance of potassium ions to virus infection, suggesting a potential therapeutic target to disrupt virus replication.Importance No antivirals are approved for the treatment of bunyavirus infection. | 2020-04-14 |
| 32284951 | On behalf of the Society of Infectious Diseases Pharmacists, we herein summarize the current evidence as of March 18, 2020 to provide guidance on potential COVID-19 treatment options. […] It is important to caution readers that new data emerges daily regarding clinical characteristics, treatment options, and outcomes for COVID-19. […] Optimized supportive care remains the mainstay of therapy, and the clinical efficacy for the subsequent agents is still under investigation. | 2020-04-16 |
| 32285293 | This article will summarize the role of ACE2 in multiple organ damage caused by COVID-19 and SARS-CoV, targeted blocking drugs against ACE2, and drugs that inhibit inflammation in order to provide the basis for subsequent related research, diagnosis and treatment, and drug development. | 2020-04-14 |
| 32285338 | Few studies have been performed on viral transmission during surgery, but to date there is no study that demonstrates or can suggest the ability for a virus to be transmitted during surgical treatment whether open or laparoscopic. | 2020-04-14 |
| 32285555 | Intensive care units are facing a surge of patients requiring invasive ventilation.It is likely that requests for a tracheostomy in COVID-19 ventilated patients will soon come our way. | 2020-04-14 |
| 32285930 | Hydroxychloroquine (HCQ) is a promising candidate for Coronavirus Disease of 2019 (COVID-19) treatment. […] Our goal was to integrate historic and emerging pharmacological and toxicity data to understand safe and efficacious HCQ dosing strategies for COVID-19 treatment. […] HCQ doses > 400 mg BID for ≥5 days were predicted to rapidly decrease viral loads, reduce the proportion of patients with detectable SARS-CoV-2 infection, and shorten treatment courses, compared to lower dose (≤400 mg daily) regimens. | 2020-04-14 |
| 32285949 | Chest computed tomography (CT) showed different abnormalities from those of conventional COVID-19, and the faster absorption of pulmonary lesions also highlights the importance of antiretroviral therapy in this patient. […] This report provides reference for the diagnosis and treatment of HIV-infected patients with COVID-19. | 2020-04-14 |
| 32286679 | A significant number of patients with pneumonia require passive oxygen therapy. […] Non-invasive ventilation and high-flow nasal oxygen therapy can be applied in mild and moderate non-hypercapnia cases. […] Specific pharmacological treatment for COVID-19 is not currently available. […] The key is a holistic approach to the patient including, primarily, the use of personal protective equipment to reduce the risk of further virus transmission, as well as patient management, which consists in both quarantine and, in the absence of specific pharmacological therapy, symptomatic treatment. | 2020-04-14 |
| 32286766 | This review analyzes information from worldwide research and experience on the epidemiology, prevention, and treatment of COVID-19, and offers links to the most reliable and trustworthy resources to help equip healthcare professionals in managing this public health challenge. | 2020-04-14 |
| 32286790 | The proposed peptide inhibitors could provide simple and efficient therapeutics against the COVID-19 disease. | 2020-04-16 |
| 32286947 | This pandemic emphasizes the need to be constantly alert to shifts in both the global dynamics and the contexts of individual countries, making sure that all are aware of which approaches are successful for the prevention, containment and treatment of new diseases, and being flexible enough to adapt the responses accordingly. | 2020-04-14 |
| 32287140 | All patients were confirmed by real-time polymerase chain reaction and were analyzed for clinical characteristics, laboratory data, and treatment. […] Patients with digestive symptoms had higher mean liver enzyme levels, lower monocyte count, longer prothrombin time, and received more antimicrobial treatment than those without digestive symptoms. | 2020-04-14 |
| 32288414 | Following Law of the People’s Republic of China on Prevention and Treatment of Infectious Diseases and other related regulations, medical institutions have been authorized to collect the detailed information of patients, while it is still a formidable task in megacities because of the significant patient mobility and the existing information sharing barrier. | 2020-04-16 |
| 32289016 | We searched 7 data sources for eligible traditional medicine guidelines up to March 6, 2020 and found a total of 28 traditional medicine guidelines that provide treatment measures for COVID-19. […] This review can be used as guidance for the traditional medicine treatment of COVID-19. | 2020-04-16 |
| 32289376 | Although the treatment and protective standards are continuously evolving, this commentary shares our thoughts on how an institution, specifically surgical services may develop collaborative process improvement to accommodate for rapid and ongoing change. | 2020-04-16 |
| 32289472 | Management is predominantly focused on the provision of supportive care, with oxygen therapy representing the major treatment intervention. […] Medical therapy involving corticosteroids and antivirals have also been encouraged as part of critical management schemes. […] However, there is at present no specific antiviral recommended for the treatment of COVID-19, and no vaccine is currently available. | 2020-04-16 |
| 32289548 | We need an effective treatment to cure COVID-19 patients and to decrease virus carriage duration. […] Furthermore, the cost of treatment is negligible. | 2020-04-16 |
| 32289565 | All patients were given antiviral therapy. | 2020-04-16 |
| 32289791 | Using Richardson and Davidson’s model and the sciences of pharmacokinetics and clinical pharmacopsychology, this article reviewed the: (1) poor life expectancy associated with treatment-resistant schizophrenia (TRS), which may be improved in patients who adhere to clozapine; (2) findings that clozapine is the best treatment for TRS (according to efficacy, effectiveness and well-being); and (3) potential for clozapine to cause vulnerabilities, including potentially lethal adverse drug reactions such as agranulocytosis, pneumonia, and myocarditis. | 2020-04-14 |
| 32290293 | Although our understanding of coronaviruses has undergone a huge leap after two precedents, the effective approaches to treatment and epidemiological control are still lacking. | 2020-04-16 |
| 32290643 | To summarize the administration model of a COVID-19 designated hospital transformed from a community hospital to improve the emergency capacity of community hospitals and the efficiency of diagnosis and treatment of medical staff in the COVID-19 pandemic. […] Analyze the surrounding environment, ward layout, area management, treatment process, medical staff and patient management of the designated community hospital. […] Its diagnosis and treatment model has completed the treatment of COVID- 19 patients successfully. […] After adjustment, this community hospital can shoulder the critical task of being a designated hospital for COVID-19, which includes admission, isolation, and therapy of suspected and mild COVID-19 patients, reducing the medical burden of superior hospitals. | 2020-04-15 |
| 32290754 | Cancer patients represent a vulnerable population due to the acquired immunodeficiency associated with anti-cancer therapy. | 2020-04-15 |
| 32290839 | Moreover, Tocilizumab treatment that blocking IL-6 receptors showed inspiring clinical results including temperature returned to normal quickly and respiratory function improved. […] Therefore, we suggest that Tocilizumab is an effective treatment in severe patients of COVID-19 to calm the inflammatory storm and reduce mortality. | 2020-04-16 |
| 32291076 | Our discovery provides clues for pathogenesis and targeted drug therapy towards ACE2 expression for prevention and adjuvant therapy of COVID-19. | 2020-04-15 |
| 32291112 | Here, we review currently registered interventional clinical trials for the treatment and prevention of COVID-19 to provide an overall summary and insight into the global response. | 2020-04-15 |
| 32291505 | However, about 5% become critically ill and require intensive care treatment. […] To date there is no specific treatment available-the main goal of supportive therapy is to ascertain adequate oxygenation. | 2020-04-15 |
| 32291526 | This editorial presents the available evidence to guide treatment practices during this pandemic. | 2020-04-16 |
| 32291542 | In this review, we summarized the epidemiological characteristics, clinical features, diagnosis, treatment, and prognosis of COVID-19. | 2020-04-15 |
| 32291906 | Thus they suggested the anticoagulant treatment in patients with coronavirus disease 2019 (COVID-19). | 2020-04-15 |
| 32291968 | Patients with cancer are more likely than the general population to contract COVID-19 because of the systemic immunosuppressive status caused by malignant diseases or anticancer treatment. […] Most patients with lung cancer are smokers with poor underlying lung conditions and low immunity, thus it is vital to protect them from epidemic diseases during cancer treatment. […] It is necessary to provide individualized medical treatment and management of treatment-related adverse events for patients with lung cancer based on patients’ conditions and regional epidemic patterns. | 2020-04-15 |
| 32292012 | Objective: Todiscuss the the effects, indications and protective measures of tracheotomy for severe cases of 2019 novel corona virus disease(COVID-19)patients. Methods: A retrospectively analyze was conducted to explore the clinical data of ofCOVID-19 patients who received tracheotomy in February to March 2020,descriptive statistics were used to analyze the indication of tracheotomy, particularity of intraoperative treatment and protective measures. Results: A total of 4 cases were included in this article, 3 cases were successfully operated, 1 case of postoperative incision continuous bleeding, there were not other complications and nosocomial infection among the medical staff.the patient’s condition was relieved in different degrees after the operation, who remain hospitalized. Conclusion: Tracheotomy for severe cases of COVID-19 can achieve certain curative effect, but the occurrence of tracheotomy related complicationsand nosocomial infection should be effectively controlled, and the risk benefit ratio of tracheotomy should be carefully weighed before surgery. 目的： 探讨新型冠状病毒肺炎危重型患者施行气管切开术的指征、术中处理的特殊性及防护措施。 | 2020-04-15 |
| 32292113 | In this commentary, we offer an alternative promising therapy for COVID-19, that is, mesenchymal stem cells (MSCs) transplantation. | 2020-04-15 |
| 32292205 | The COVID-19 epidemic should be considered a global threat and the steps for control include early diagnosis and treatment, as well as isolation. | 2020-04-15 |
| 32292260 | Several dental care facilities in affected countries have been completely closed or have been only providing minimal treatment for emergency cases. […] However, several facilities in some affected countries are still providing regular dental treatment. | 2020-04-15 |
| 32292517 | Three kinds of responses to clinical treatment were defined and evaluated: 1) good, symptoms continually improved; 2) fair, symptoms not improved or relapsed; 3) poor, symptoms aggravated. […] The progression in abnormal imaging findings indicate a poor/fair response, whereas the alleviated symptoms seen from CT suggest a good response. Conclusion: Most cases are no-emergency type and have a favorable response to clinical treatment. […] Follow-up CT changes during the treatment can help evaluate the treatment response of patients with NCP. | 2020-04-16 |
| 32292529 | As the epicentre of the initial outbreak, China has been updating the National COVID-19 Diagnostic and Treatment Guideline with up-to-date information about the disease. | 2020-04-15 |
| 32292587 | Our study aimed to present an overview of the virus in terms of structure, epidemiology, symptoms, treatment, and prevention. | 2020-04-15 |
| 32292627 | Collectively, these results suggest that MSCs significantly improve survival rate of H7N9 induced ARDS and provide a theoretical basis for the treatment of H7N9 induced ARDS in both preclinical research and clinical studies. […] Because H7N9 and the corona virus disease 2019 (COVID-19) share similar complications (such as ARDS and lung failure) and corresponding multi-organ dysfunction, MSC-based therapy could be a possible alternative for treating COVID-19. | 2020-04-15 |
| 32292632 | By taking these strategies, the hospital effectively improved the coping capacity of the nursing team and played a positive role in the prevention and treatment of COVID-19. | 2020-04-15 |
| 32292634 | This consensus included nursing assessment, nursing priorities, nursing goals, and thirteen key points of nursing procedures such as nursing of oxygen therapy and respiratory nursing. | 2020-04-15 |
| 32292636 | This article aims to summarize a series of contingency management strategies of the Nursing Department in the centralized treatment of patients with coronavirus disease 2019(COVID-19). […] The strategies of the Nursing Department included early warning for prevention and control, taking functions of vertically commanding and horizontally coordinating, and reasonably allocating nursing workforce, to facilitate centralized treatment work in the in-hospital fever clinic, isolation wards and ICU, and referral and admission of critical patients. […] Through the implementation of these strategies, safe and efficient centralized treatment was ensured timely, orderly and sustainably. | 2020-04-15 |
| 32292686 | To date, there is no specific therapy for COVID-19. | 2020-04-15 |
| 32292691 | Using spatial panel models, we analyse the relationship between confirmed cases of COVID-19, deaths thereof, and recovered cases due to treatment. | 2020-04-15 |
| 32292693 | The current health crisis caused by COVID-19 is a challenge for oncology treatment, especially when it comes to radiotherapy. […] In order to treat patients safely while protecting medical teams, the entire health care system must optimize the way it approaches prevention and treatment at a time when social distancing is key to stemming this pandemic. […] All indications and treatment modalities must be re-discussed. […] In this short piece, the members of the GEMO (the European Study Group of Bone Metastases) offer a number of recommendations to achieve the above objectives, both in general and in relation to five of the most common situations on radiation therapy for bone metastases. | 2020-04-15 |
| 32292697 | Osteonecrosis of the femoral head (ONFH) is a common disabling complication among convalescent SARS patients who received corticosteroid therapy. […] In China, a considerable number of convalescent SARS patients with steroid-associated ONFH had undergone conservative treatment by Traditional Chinese Medicine (TCM), and this study aims to evaluate the long-term results of a spleen-invigorating Huo-Gu Formula (HGF) therapy in these patients. and methods: A total of 33 convalescent SARS patients (nine males and 24 females) with bilateral steroid-associated ONFH (66 hips) were enrolled in this study. […] All patients received oral HGF therapy for six months when they were confirmed the diagnosis of steroid-associated ONFH. […] Based on average 14 years of follow-up of HGF therapy (ranging from six to 16 years), 38 hips (57%) among the 66 hips developed definite osteoarthritis, and 14 hips (26%) in 53 pre-collapse hips (ARCO stage I or II) progressed to femoral head collapse(ARCO stage III or IV). […] Chinese herbal HGF therapy demonstrates beneficial effects on preventing femoral head collapse, delaying total hip arthroplasty (THA)surgery, and maintaining physical function in the treatment of steroid-associated ONFH. […] HGF therapy might be therefore a good alternative for the treatment of steroid-associated ONFH secondary to rheumatologic and infection diseases. | 2020-04-15 |
| 32292802 | In addition we have also provided information about transmission dynamics, prevention measures and treatment options that are available at the present. […] Joint efforts of global scientific community are needed at this hour in terms of enhancement of research on development of accurate diagnostics, antiviral therapeutics and finally into formation of an effective vaccine against the emerging novel coronavirus. | 2020-04-15 |
| 32292805 | Unfortunately, for most of them, the drug products available on the market are not designed to be administered by a nasogastric tube to inpatients of intensive care units. | 2020-04-15 |
| 32292817 | We have studied its use as an antimalarial, an antiviral, and an immunomodulating drug and concluded that the use of HCQ at does matching that of the standard treatment of Systemic Lupus erythematous, which has proven safety and efficacy in terms of HCQ blood and tissue concentration adapted to bodyweight (2,3), at 6 mg/kg/day 1 (loading dose) followed by 5 mg/kg/day, with a maximum limit of 600 mg/day in all cases should swiftly be clinically evaluated as a post-exposure drug for exposed people. | 2020-04-15 |
| 32292826 | While there is no intervention for the prevention or treatment of COVID-19 with proven clinical efficacy to date, tools to distil the current research landscape by intervention, level of evidence and those studies likely powered to address future research questions is essential. | 2020-04-15 |
| 32292839 | During a global pandemic the benefit of routine visits and treatment of cancer patients must be weighed against the risks to patients, staff, and society. […] Treatment can be avoided or delayed until safe for very low, low, and favorable intermediate-risk disease. […] Unfavorable intermediate-risk, high-risk, clinical node positive, recurrence post-surgery, oligometastatic, and low-volume M1 disease can receive neoadjuvant hormone therapy for 4-6 months as necessary. | 2020-04-15 |
| 32292847 | Dealing with the immense challenge of COVID-19 disease, confronted with severely ill patients in dire straits with virtually no rigorous evidence base to guide our therapy, we must call upon our clinical skills and judgment. […] Lacking a robust evidence base, pathophysiologic reasoning can help guide our choices of therapy for individual clinical scenarios. | 2020-04-15 |
| 32292848 | We review the most current data with a focus on our basic understanding of the mechanism(s) of disease and translation to the clinical syndrome and potential therapeutics. | 2020-04-15 |
| 32292866 | During the first phase of the disease (from onset of the symptoms up to 7-10 days) viral-induced effects are prominent with the opportunity to institute antiviral therapy. | 2020-04-15 |
| 32292904 | The diagnosis, infection control, and treatment of COVID-19 in hemodialysis patients are discussed in this report, and we conclude with recommendations for how a dialysis facility can respond to COVID-19 based on our experiences. | 2020-04-15 |
| 32292909 | For this emergency, the FDA has approved Remdesivir and Hydroxychloroquine for treatment of COVID-19 as Emergency Use Authorization. | 2020-04-15 |
| 32292917 | We describe the percutaneous treatment of an unprotected left main coronary artery in a patient who is positive for coronavirus disease 2019 with unstable angina, dyspnea and fever. | 2020-04-15 |
| 32293003 | This raised multiple questions regarding a more severe course of COVID-19 in relation to hypertension itself as well as its treatment with renin-angiotensin system (RAS) blockers, e.g. angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin receptor blockers (ARBs). […] We also review in detail the molecular mechanisms linking the RAS to lung damage and the potential clinical impact of treatment with RAS blockers in patients with COVID-19 and a high cardiovascular and renal risk. | 2020-04-15 |
| 32293020 | Symptomatic (palliative) treatment is of fundamental importance both in conjuncture with life-sustaining interventions and in end of life care. […] Based on the evidence to date, there are several treatment options to consider for the relief of fever (acetaminophen, NSAID, oral glucocorticoids), cough (morphine), breathlessness (morphine, oxygen, fan), anxiety (benzodiazepines) and pain (NSAID, morphine). […] Top priorities include precautions to protect staff and people at-risk from infection and planning how to provide adequate treatment for each individual depending on setting, including palliative care. | 2020-04-16 |
| 32293168 | Thus, we have successfully fabricated a promising FET biosensor for SARS-CoV-2; our device is a highly sensitive immunological diagnostic method for COVID-19 that requires no sample pretreatment or labeling. | 2020-04-15 |
| 32293713 | In order to evaluate the efficacy of convalescent plasma therapy in COVID-19 patients, we did this timely descriptive study. 6 laboratory confirmed COVID-19 patients were enrolled and received the transfusion of ABO-compatible convalescent plasma. […] No obvious adverse effect observed during the treatment. […] In patient #1 and #5 who presented with SARS-CoV-2 in throat swab, convalescent plasma therapy elicited an elimination of virus. […] This study indicates that convalescent plasma therapy is effective and specific for COVID-19. […] This intervention has a special significance for eliminating SARS-CoV-2 and is believed to be a promising state-of-art therapy during COVID-19 pandemic crisis. | 2020-04-15 |
| 32293714 | The patient recovered after treatment and was discharged. | 2020-04-15 |
| 32293715 | A backlog of procedures after the end of the COVID-19 pandemic is inevitable, and hospitals should plan how to address this effectively to ensure that patients having elective treatment have the best possible outcomes. | 2020-04-15 |
| 32293807 | Several antiretroviral drugs are being considered for the treatment of COVID-19, the disease caused by a newly identified coronavirus, (SARS-CoV-2). […] We systematically reviewed the clinical outcomes of using antiretroviral drugs for the prevention and treatment of coronaviruses and planned clinical trials. […] From an initial screen of 433 titles, two randomized trials and 24 observational studies provided clinical outcome data on the use of antiretroviral drugs; most studies reported outcomes using LPV/r as treatment. […] Of the 21 observational studies reporting treatment outcomes, there were three studies among patients with SARS, six studies among patients with MERS and 12 studies among patients with COVID-19. | 2020-04-16 |
| 32293831 | The precautions to be taken against this virus, where our knowledge is extremely small, intensive care units take an indispensable place in pandemic planning. | 2020-04-16 |
| 32293834 | Currently, there is not any specific effective anti-viral treatment for COVID-19. […] Optimized supportive care remains the mainstay of therapy. […] Despite the urgent need to find an effective antiviral treatment for COVID-19 through randomized controlled studies, certain agents are being used all over the world based on either in-vitro or extrapolated evidence or observational studies. […] Nitazoxanide and ivermectin were also included in this review as they have recently been reported to have an activity against SARS-CoV-2 in-vitro and are licensed for the treatment of some other human infections. | 2020-04-15 |
| 32293835 | Unfortunately, there is no medication that has been approved by the FDA, gone through controlled studies and demonstrated an effect on the virus for this global pandemic. | 2020-04-15 |
| 32293910 | Appropriate treatment for heart failure, arrhythmias, acute coronary syndrome and thrombosis remain important. […] Specific evidence based treatment strategies for COVID-19 will emerge with ongoing global collaboration on multiple approaches being evaluated. | 2020-04-15 |
| 32294179 | Here we review the basic and clinical science spanning the intersections of diabetes, coronavirus infections, ACE2, and DPP4 biology, highlighting clinical relevance and evolving areas of uncertainty underlying the pathophysiology and treatment of T2D in the context of coronavirus infection. | 2020-04-15 |
| 32294289 | In this retrospective analysis, conducted at the Tongji Hospital of Wuhan, China, it is reported that heparin treatment reduces mortality in subjects affected by severe COVID-19 who have “sepsis-induced coagulopathy”. | 2020-04-15 |
| 32294485 | The severity on admission, complications, treatment, and outcomes of COVID-19 patients were evaluated. | 2020-04-15 |
| 32294562 | Several antiviral medications: Zanamivir, Indinavir, Saquinavir, and Remdesivir show potential as and 3CLPRO main proteinase inhibitors and as a treatment of COVID-19. […] It is also exciting to uncover that Flavin Adenine Dinucleotide (FAD) Adeflavin, B2 Deficiency medicine, and Coenzyme A, a coenzyme, may also be potentially used for the treatment of SARS-CoV-2 infections. […] The use of these off-label medications may be beneficial in the treatment of the COVID-19. | 2020-04-15 |
| 32294763 | The transfer of the patients after acute care treatment is needed urgently to facilitate the weaning process. […] In a next step we developed a triage algorithm to identify patients at SAVE intensive care units with potential to wean and transfer to weaning institutions - we called POST SAVE. […] This manuscript highlights the algorithms including the use of a standardised digital evaluation tool, the use of trained navigators to facilitate the communication between SAVE intensive care units and weaning institutions and the establishment of a prospective data registry for patient assignment and reevaluation of the weaning potential in the future. | 2020-04-15 |
| 32294807 | At present, there are no studies demonstrating the clinical efficacy of hydroxychloroquine for the prophylaxis or treatment of COVID-19 infection. | 2020-04-15 |
| 32294811 | The treatment of critically ill patients with coronavirus disease 2019(COVID-19) faces compelling challenges. […] In this issue, we’d like to share our first-line treatment experience in treating COVID-19. […] Nutritional support is the basis of treatment. […] It’s important to establish individual therapy regimens and to evaluate, monitor and adjust dynamically. | 2020-04-17 |
| 32294813 | As such, we developed this consensus recommendations on all those high-risk treatments, based on the current evidence as well as the resource limitation in some areas, with the aim to reduce the nosocomial transmission and optimize the treatment for the COVID-19 pneumonia patients. […] Those recommendations include: (1)Standard prevention and protection, and patient isolation; (2)Patient wearing mask during HFNC treatment; (3)Using dual limb ventilator with filters placed at the ventilator outlets, or using heat-moisture exchanger (HME) instead of heated humidification in single limb ventilator with HME placed between exhalation port and mask; avoid using mask with exhalation port on the mask; (4)Placing filter between resuscitator and mask or artificial airway; (5)For spontaneous breathing patients, placing mask for patients during bronchoscopy examination; for patients receiving noninvasive ventilation, using the special mask with bronchoscopy port to perform bronchoscopy; (6)Using sedation and paralytics during intubation, cuff pressure should be maintained between 25-30 cmH(2)O(1 cmH(2)O=0.098 kPa); (7)In-line suction catheter is recommended and it can be used for one week; (8)Dual-limb heated wire circuits are recommended and only changed with visible soiled; (9)For patients who need breathing support during transportation, placing an HME between ventilator and patient; (10)PSV is recommended for implementing spontaneous breathing trial (SBT), avoid using T-piece to do SBT. […] (11)Avoid unnecessary bronchial hygiene therapy; (12) For patients who need aerosol therapy, dry powder inhaler metered dose inhaler with spacer is recommended for spontaneous breathing patients; while vibrating mesh nebulizer is recommended for ventilated patients and additional filter is recommended to be placed at the expiratory port of ventilation during nebulization. | 2020-04-17 |
| 32294816 | The results showed that the positive rate of bronchoalveolar lavage for detection of new coronavirus nucleic acid was high, and bronchoalveolar lavage for suspected or confirmed new coronavirus pneumonia patients with negative detection of nucleic acid in pharynx swabs but still residual lung lesions was helpful for early diagnosis, treatment and prognosis. | 2020-04-17 |
| 32294817 | But the pathogenesis and treatment of the disease are not clear yet. | 2020-04-17 |
| 32295300 | To date, protease inhibitor drugs, especially HIV-1 protease inhibitors, have been available for human clinical use in the treatment of coronaviruses. | 2020-04-17 |
| 32295322 | Objective: To analyze the epidemiological characteristics and clinical features of the patients with 2019-nCoV infection in Nanyang City, so as to provide evidence for clinical diagnosis and treatment. Methods: The epidemiology, clinical symptoms, atory and radiologic data of 150 patients with 2019-nCoV infection admitted to the designated hospitals in Nanyang City from January 24,2020 to February 16, 2020 were retrospectively analyzed. Results: The 150 patients with 2019 nCov infection consisted of 67 men and 83 women, and the median age was 45±16 years; 69 of them were the first generation case,60 of them were the second generation case, 6 of them were the third generation case,the median incubation period of the first generation case was 5.4±2.2 days, and the second generation case was 6.7±3.1 days, and the first-generation cases are the majority in severe patients (69%) . […] After active treatment, 45% of patients were discharged according to discharge standards. 33% of sever and critically ill patients were discharged, 49% of them were degraded hospitalization.The average length of hospitalization was 12±4 days. Conclusion: A history of epidemiological exposure, fever, chest CT with signs of pneumonia, normal or decreased WBC, and lymphocytopenia, eosinophilia are the clinical basis for the diagnosis of this disease, and most of the sever patients were the first generation cases. | 2020-04-16 |
| 32295323 | Sleep study and non-invasive positive airway pressure (NIPAP) therapy can increase the risk of exposure and transmission of new coronaviruses to medical staff and patients. […] Based on the characteristics of sleep-disordered breathing, this consensus elaborates on the recommendations from the following four aspects that include patient and medical staff education, optimization of diagnostic and treatment protocols, sterilization of medical devices and the environment, and control of hospital-acquired infection. | 2020-04-16 |
| 32295658 | In this comment, we report the unexpected beneficial effect of a deployable rapid-assembly shelter hospital on the prevention and treatment of COVID-19. […] We describe the shelter hospital maintenance, treatment mode and primary treatment methods, which will provide a valuable experience in dealing with public health emergencies, such as COVID-19, for other countries and areas. | 2020-04-30 |
| 32296259 | One postexposure prophylaxis, convalescent (immune) plasma (CP), has shown some success in China and previously in the cure and therapy of other coronaviruses, SARS-1 and Middle East respiratory syndrome. | 2020-05-31 |
| 32296735 | In response to the outbreak of COVID-19 that has been sweeping the world, scientists reconstructed the SARS-CoV-2 rapidly using a synthetic genomics platform, in order to accelerate therapeutics and vaccine development. | 2020-05-13 |
| 32296817 | The few trials which allow their inclusion focus on post-exposure prophylaxis or outpatient treatment of milder disease, limiting the options available to pregnant women with severe COVID-19 to compassionate use of remdesivir, or off-label drug use of hydroxychloroquine or other therapies. […] In this Viewpoint, we call attention to the need and urgency to engage pregnant women in COVID-19 treatment trials now in order to develop data-driven recommendations regarding the risks and benefits of therapies in this unique but not uncommon population. | 2020-04-30 |
| 32296824 | Our nomogram could help clinicians to early identify patients who will exacerbate to severe COVID-19, which will enable better centralized management and early treatment of severe patients. | 2020-04-30 |
| 32296888 | For urology, the expansion of the health-care structures for the treatment of patients suffering from COVID-19 should be supported as best as possible. […] For this, patients must be prioritized individually, alternative therapy concepts must be considered and regional and supraregional cooperation must be used. […] Outpatient departments are of great importance in the care, examination and coordination of urological emergencies and urgent treatment. | 2020-04-20 |
| 32296910 | We propose several mechanisms by which coronavirus disease 2019 causes thrombocytopenia to better understand this disease and provide more clinical treatment options. | 2020-05-22 |
| 32297089 | The development of COVID-19 syndrome in anticoagulated patients, and especially their admission to intensive-care units with acute severe respiratory syndrome (SARS-CoV-2), expose them to specific problems related to their therapy, in addition to those associated with the acute viral infection. […] Patients on DOAC are exposed to under/over treatment caused by significant pharmacological interferences. […] In consideration of the pharmacological characteristics of oral anticoagulant drugs, the multiple pharmacological interactions due to the treatment of acute disease and the possible necessity of mechanical ventilation with hospitalization in intensive-care units, we suggest replacing oral anticoagulant therapies (VKA and DOAC) with parenteral heparin to avoid the risk of over/under treatment. | 2020-05-10 |
| 32297571 | Here we report on the most recent updates on experimental drugs successfully em-ployed in the treatment of the disease caused by SARS-CoV-2 coronavirus, also referred to asCOVID-19 (COronaVIrus Disease 19). […] Since the recoveries/deathsratio in the last weeks significantly increased, especially in China, it is clear that the experi-mental antiviral therapy, together with the availability of intensive care unit beds in hospitalsand rigorous government control measures, all play an important role in dealing with this vi-rus. | 2020-04-21 |
| 32297671 | After ‘five-in-one’ treatment, all patients were discharged with the exception of the four who died. | 2020-04-30 |
| 32297723 | At present, treatment of COVID-2019 is mostly based on the knowledge gained from the SARS and MERS outbreaks. […] Remdesivir, originally develop as a treatment for Ebola virus disease and Marburg virus infections, is being studied for it effectiveness against 2019-nCoV infection. | 2020-04-20 |
| 32297727 | The BCRSS uses patient examination features along with the need for escalating levels of respiratory support (NIV, intubation, proning) to suggest treatment recommendations. | 2020-04-20 |
| 32297843 | With few safe and effective drugs available to combat this threat to humanity and the normal functioning of our society, the oligonucleotide research community is uniquely positioned to apply its technology and expertise to help alleviate the crisis, thanks to its capacity for rational drug design, swift development cycles, and pursuing targets undruggable by conventional treatment strategies. | 2020-05-29 |
| 32297985 | Patients confirmed with COVID-19 pneumonia were enrolled and divided into 7 groups according to the treatment option. […] The chest CT imaging obtained at admission and after a 5-d treatment cycle were assessed. […] No significant differences were found among the groups in terms of the proportion of patients with pneumonia resolution (P=0.151) after treatment or the length of hospital stay (P=0.116). […] According to the results, the inclusion of antiviral drugs in therapeutic regimens based on symptomatic treatment had no significant additional impact on the improvement in COVID-19 patients. | 2020-04-16 |
| 32297987 | Particularly, no approved therapy has demonstrated to have an impact in treating patients who develop severe respiratory insufficiency so far. | 2020-04-16 |
| 32297988 | Treatment with HCQ resulted in less number of cases showing the radiological progression of lung disease (odds ratio [OR], 0.31, 95% confidence interval [CI], 0.11-0.9). […] No difference was observed in virological cure (OR, 2.37, 95% CI, 0.13-44.53), death or clinical worsening of disease (OR, 1.37, 95% CI, 1.37-21.97), and safety (OR, 2.19, 95% CI, 0.59-8.18), when compared with the control/conventional treatment. […] HCQ seems to be promising in terms of less number of cases with radiological progression with a comparable safety profile to control/conventional treatment. | 2020-05-03 |
| 32298029 | Patients who need to be hospitalized for cancer treatment were protected from potential SARS-CoV-2 infection by creating a dedicated diagnostic and therapeutic internal pathway for cancer treatment. […] Because of the extreme burden created by COVID-19, antitumor treatment was initiated only after considering patient performance status, comorbidities, biology of disease, and the likely impact of treatment on outcome. […] Treatment strategies were discussed in the context of a multidisciplinary tumor board. […] Treatment decision making balanced risk and benefits of treatment in the context of the specific pandemic level, on a case-by-case basis. | 2020-04-27 |
| 32298036 | Unique considerations for the head and neck patient are examined including risk to the oncology patient, outcomes following delay in head and neck cancer therapy, and risk of transmission during otolaryngologic surgery. | 2020-05-29 |
| 32298139 | Outbreaks generate geospatial “hotspots.” POC strategies help control hotspots, detect spread, and speed treatment of highly infectious diseases. Objectives. To stop outbreaks, accelerate detection, facilitate emergency response for epidemics, mobilize public health practitioners, enhance community resilience, and improve crisis standards of care. Data Sources. PubMed, WWW, newsprint, others were searched until COVID-19 was declared a pandemic, the US, a national emergency, and Europe, the epicenter. | 2020-04-16 |
| 32298208 | However, out-of-hospital professionals cannot access patient information, which has greatly reduced the efficiency of treatment; it is inconvenient for health care professionals to issue a case discussion with professionals from other wards. | 2020-04-16 |
| 32298245 | Actions such as social distancing are especially critical when medical countermeasures such as vaccines or therapeutics are not available. | 2020-04-17 |
| 32298480 | Infantile hemangiomas (IH) can require urgent evaluation and risk stratification to determine which infants need treatment and which can be managed with continued observation. […] For those requiring treatment, prompt initiation decreases morbidity and improves long-term outcomes. […] FDA/EMA-approved monitoring guidelines, clinical practice guidelines, and relevant, up-to-date publications regarding initiation and monitoring of beta-blocker therapy were used to inform the recommendations. […] Clinical decision-making guidelines about when telehealth is an appropriate alternative to in-office visits, including medication initiation, dosage changes, and ongoing evaluation, are included. […] The importance of communication with caregivers in the context of telemedicine is discussed, and online resources for both hemangioma education and propranolol therapy are provided. | 2020-05-16 |
| 32298745 | The patient avoided mechanical ventilation and acquired an immediate clinical and radiological improvement, after treatment of intensive plasma exchange (PE) followed by intravenous immunogloblin (IVIG). […] Successful therapeutic strategies in our case suggest timely initiating PE treatment followed by IVIG in critically ill patients with COVID-19 may prevent the disease from worsening and help to reduce the requirements for mechanical ventilation and intensive supportive care. | 2020-05-05 |
| 32298748 | We provide resources for health care providers, in addition to calling on palliative care providers to consider their own role as a resource to other specialties during this public health emergency. | 2020-04-27 |
| 32298803 | Fear of illness and uncertainty about the future precipitate anxiety- and stress-related disorders, and several groups have rightfully called for the creation and dissemination of robust mental health screening and treatment programs for the general public and front-line healthcare workers. | 2020-04-24 |
| 32298807 | The SARS-CoV-2 coronavirus (COVID-19) pandemic has significantly impacted the delivery of cellular therapeutics, including chimeric antigen receptor (CAR) T cells. […] Based on the collective experience of the CAR T-cell Consortium investigators, we review and address several questions and concerns regarding cellular therapy administration in the setting of COVID-19 and make general recommendations to address these issues. […] Specifically, we address (1) necessary resources for safe administration of cell therapies; (2) determinants of cell therapy utilization; (3) selection among patients with B cell non-Hodgkin lymphomas and B cell acute lymphoblastic leukemia; (4) supportive measures during cell therapy administration; (5) use and prioritization of tocilizumab; and (6) collaborative care with referring physicians. […] These recommendations were carefully formulated with the understanding that resource allocation is of the utmost importance, and that the decision to proceed with CAR T cell therapy will require extensive discussion of potential risks and benefits. […] Although these recommendations are fluid, at this time it is our opinion that the COVID-19 pandemic should not serve as reason to defer CAR T cell therapy for patients truly in need of a potentially curative therapy. | 2020-05-05 |
| 32298981 | PubMed database and Google Scholar were searched using the key terms ‘COVID-19’, ‘SARS-CoV-2’, ‘diabetes’, ‘antidiabetic therapy’ up to April 2, 2020. | 2020-05-27 |
| 32298982 | and Aims: No valid treatment or preventative strategy has evolved till date to counter the SARS CoV 2 (Novel Coronavirus) epidemic that originated in China in late 2019 and have since wrought havoc on millions across the world with illness, socioeconomic recession and death. | 2020-05-29 |
| 32299202 | Regretfully, the exact pathophysiology and treatment, especially for the severe COVID-19, is still uncertain. […] The results of preliminary studies have shown that immune-modulatory or immune-suppressive treatments such as hydroxychloroquine, interleukin (IL)-6 and IL-1 antagonists, commonly used in rheumatology, might be considered as treatment choices for COVID-19, particularly in severe disease. | 2020-04-22 |
| 32299204 | The case definition, finding out cases and first case cluster, proper treatment, sufficient stockpiles of medicine and population cooperation with the containment strategy should be considered for reduction of burden of pandemic. | 2020-04-22 |
| 32299753 | If baseline electrocardiographic testing reveals a moderately prolonged QTc, optimization of medications and electrolytes may permit therapy. | 2020-05-18 |
| 32300516 | Ultimately, treatment decisions should be made on the basis of dialogue between patient and provider, considering each patient’s individualized situation. | 2020-05-16 |
| 32300673 | Information on the variation of viruses is of considerable medical and biological impacts on the prevention, diagnosis, and therapy of infectious diseases. | 2020-04-21 |
| 32300796 | These similarities are explored here, and underscore the need to consider the role of basic biological mechanisms of aging on potential treatment and outcomes of COVID-19. | 2020-04-30 |
| 32301099 | We reported on the epidemiological, clinical, laboratory, and radiological characteristics of children cases to help health workers better understand and provide timely diagnosis and treatment. | 2020-05-29 |
| 32301198 | Here, we report the clinical features and our treatment approach for a kidney transplant patient with a diagnosis of COVID-19. | 2020-05-22 |
| 32301284 | Quantitative smell testing demonstrates that decreased smell function, but not always anosmia, is a major marker for SARS-CoV-2 infection and suggests the possibility that smell testing may help, in some cases, to identify COVID-19 patients in need of early treatment or quarantine. | 2020-04-17 |
| 32301300 | However, there is a risk of cross-infection at each stage of screening treatment, including the booths, and adverse reactions with disinfection of the booths. | 2020-04-20 |
| 32301600 | However, considering the initial data and lack of comprehensive knowledge on the pathogenesis of SARS-CoV-2 during pregnancy, human reproduction societies have recommended postponing the embryo transfers and do not initiate new treatment cycles. | 2020-04-28 |
| 32301764 | The pandemic of coronavirus disease 2019 (COVID-19) has several implications relevant to neuroanesthesiologists, including neurologic manifestations of the disease, impact of anesthesia provision for specific neurosurgical procedures and electroconvulsive therapy, and healthcare provider wellness. […] This consensus statement provides information on the neurological manifestations of COVID-19, advice for neuroanesthesia clinical practice during emergent neurosurgery, interventional radiology (excluding endovascular treatment of acute ischemic stroke), transnasal neurosurgery, awake craniotomy and electroconvulsive therapy, as well as information about healthcare provider wellness. | 2020-05-22 |
| 32301766 | We review current knowledge of the role of ACE2 in cardiovascular physiology and SARS-CoV-2 virology as well as clinical data to inform the management of patients with or at risk for COVID-19 who require renin-angiotensin-aldosterone system inhibitor therapy. | 2020-05-16 |
| 32301817 | For patients with developmental or chronic orthopaedic conditions, it may be possible to delay treatment for 2 to 4 months without substantial detrimental long-term impact. | 2020-04-18 |
| 32301997 | The patients were divided into three groups according to the “Diagnosis and Treatment of New Coronavirus Pneumonia (6th edition)” issued by the National Health Commission of China. | 2020-04-30 |
| 32302058 | Rapid and accurate laboratory testing of SARS-CoV-2 is essential for early discovery, early reporting, early quarantine, early treatment, and cutting off epidemic transmission. | 2020-05-19 |
| 32302257 | Finally, recommendations based on the Italian experience in terms of patient triage, patients’ entrance into the practice, dental treatment, and after-treatment management are reported and discussed. | 2020-04-17 |
| 32302280 | The National Institutes of Health is conducting a Phase 1 clinical trial to evaluate for a potential vaccine and the recipients have started to receive the investigational vaccine.2 We present a brief overview of the potential prophylactic and treatment agents under investigation, some which could be initiated in the ED if proven effective. | 2020-05-21 |
| 32302411 | It is primarily used for the treatment of respiratory, enteric, and genitourinary bacterial infections. […] AZ is not approved for the treatment of viral infections, and there is no well-controlled, prospective, randomized clinical evidence to support AZ therapy in coronavirus disease 2019 (COVID-19). […] Nevertheless, there are anecdotal reports that some hospitals have begun to include AZ in combination with hydroxychloroquine or chloroquine (CQ) for treatment of COVID-19. […] It is essential that the clinical pharmacology (CP) characteristics of AZ be considered in planning and conducting clinical trials of AZ alone or in combination with other agents, to ensure safe study conduct and to increase the probability of achieving definitive answers regarding efficacy of AZ in the treatment of COVID-19. | 2020-05-12 |
| 32302419 | Although COVID-19 does not have epidermotropism, cutaneous manifestations in Cov-19 positive patients have been reported [3] and departments of dermatology are considered at high risk [4] and were ordered to admit only patients needing urgent treatments or undergoing chronic immunosuppressive therapy in order to minimize nosocomial virus spread. | 2020-04-17 |
| 32302438 | These findings may explain the events of venous thromboembolism observed in some of these patients and support antithrombotic prophylaxis/treatment. | 2020-04-17 |
| 32302448 | Further studies are needed to assess the best prophylaxis and treatment of this condition. | 2020-05-06 |
| 32302462 | While we agree that this interim guidance addresses important considerations for monitoring the disease process, we believe that the proposed treatment strategy of prophylactic low molecular weight heparin (LMWH) to treat severe COVID-19 coagulopathy is an unconvincing strategy. | 2020-04-17 |
| 32302681 | Two pandemic scenarios, early (risk mitigation) and late (severely reduced radiation therapy resources), were evaluated. […] The panel developed treatment recommendations for 5 HNC cases. […] There was agreement or strong agreement across a number of practice areas, including treatment prioritization, whether to delay initiation or interrupt radiation therapy for intercurrent SARS-CoV-2 infection, approaches to treatment (radiation dose-fractionation schedules and use of chemotherapy in each pandemic scenario), management of surgical cases in event of operating room closures, and recommended adjustments to outpatient clinic appointments and supportive care. | 2020-05-27 |
| 32302817 | It has been associated with anxiety including multiple clinical activities, depression in the face of the coexistence of countless deaths, long work shifts with the most diverse unknowns and demands in the treatment with patients with COVID-19. | 2020-05-19 |
| 32302954 | Early detection and identification of critically ill patients is necessary to facilitate scientific classification and treatment. […] We collected and analyzed epidemiological, demographic, clinical, laboratory, radiological, and treatment data. | 2020-05-27 |
| 32302966 | The top three most popular themes were prevention and control procedures, medical treatment and research, and global or local social and economic influences, accounting for 32.57% (n=2538), 16.08% (n=1258), and 11.79% (n=919) of the collected reports, respectively. | 2020-05-04 |
| 32303077 | Because no treatment, no vaccine and no herd immunity exist, social distancing is the best mechanism available to protect patients and health care workers from infection. | 2020-04-17 |
| 32303365 | In this document we review two simple adjuvant therapies to administer, without side effects, and low cost that could be useful for the treatment of acute severe coronavirus infection associated with acute respiratory syndrome (SARS-CoV-2). […] VitaminC, a potent antioxidant, has emerged as a relevant therapy due to its potential benefits when administered intravenous. […] Another potential effective therapy is ozone: it has been extensively studied and used for many years and its effectiveness has been demonstrated so far in multiples studies. | 2020-05-21 |
| 32303420 | Specialties with overlap in therapies should have well defined arrangements among each other concerning the treatment spectra in order to avoid redundancy and loss of resources. | 2020-05-12 |
| 32303485 | In the context of the current pandemic, there is a need for specific advice concerning treatment of patients with Head and Neck cancers. | 2020-05-22 |
| 32303497 | One potential treatment is chloroquine and its derivatives, including hydroxychloroquine, which have both antiviral and anti-inflammatory effects. | 2020-04-18 |
| 32303509 | We discuss approaches to decrease the morbidity and mortality in patients with COVID-19 by repurposing existing drugs previously developed for cancer therapy. | 2020-05-02 |
| 32303607 | Further considerations are given to service provision, medical and surgical therapy, endoscopy, imaging and clinical trials. | 2020-05-13 |
| 32303609 | Moreover, the potential implications of these new insights for immunomodulation and biological therapy in IBD are discussed. | 2020-05-14 |
| 32303672 | His general practitioner suspected a urinary tract infection and prescribed him antibiotic therapy. […] After 2 days of antibiotic therapy the fever still persisted, so the individual was admitted to the local hospital and treated with broad-spectrum antibiotics. […] Considering the worsening of the chest X-ray and fever despite 48 h of broad-spectrum antibiotic therapy, we strongly suspected viral pneumonia. […] SARS-CoV-2 was detected and antiviral therapy with Lopinavir/Ritonavir, associated with hydroxychloroquine, was promptly started. […] Fever ceased after 2 days of therapy. […] Moreover, routine testing of patients who have to participate in therapy in common gym areas may be warranted. | 2020-04-24 |
| 32303821 | In the recommendations of the German Society for Rheumatology (www.dgrh.de), it is recommended that our patients continue the antirheumatic therapy to maintain remission or low state of activity despite the pandemic. […] In this study, patients with inflammatory rheumatic disease were asked in the first weeks of the pandemic on their opinion of their immunomodulating therapy. […] The result shows that over 90% of the patients followed the recommendation of the rheumatologist to continue the antirheumatic therapy, and only a small percentage of the patients terminated the therapy on their own. […] This result was independent of the individual anti-rheumatic therapy. | 2020-05-08 |
| 32303885 | All meet the indication for tracheal intubation announced by treatment expert group. | 2020-05-08 |
| 32303925 | These burdens can affect the physical, emotional, and social well-being of PLWH and interfere with the delivery of effective healthcare and access to HIV treatment. | 2020-05-25 |
| 32304191 | The epidemiological and clinical patterns of COVID-19 and treatment approaches in pediatric patients still remain unclear although many pediatric reports are published. […] This review aims to summarize the current epidemics, clinical presentations, diagnosis, and treatment of COVID-19 in pediatric patients. | 2020-04-22 |
| 32304192 | “COVID-19 Risk Assessment”, “COVID-19 Guideline” and “Case Report Form”, regulations of personal protective equipment along with need-based guidelines, treatment algorithms, brochures and related documents have been released. | 2020-04-22 |
| 32304276 | Urgent joined research efforts regarding the SARS-COV-2 rapid tests, accurate diagnosis, especially early recognition, and effective treatment of life-threatening complications would be highly desirable for humanity and medical workforce all over the world that try to combat a current global pandemic threat. […] Due to indirect complex effect, intensified COVID-19 therapies and multi-drug treatment, it is believed that some oral conditions could be aggravated by COVID-19 disease, particularly those with autoimmune aetiology, linked to compromised immune system or long-term pharmacotherapy. | 2020-05-06 |
| 32304393 | Thus, extreme caution and thoughtful approaches should be taken for a timely detection in delicate LVAD populations, especially if patients are living in a high-density COVID-19-infected area, and the potential intention for LVAD treatment is bridge to transplantation. | 2020-05-30 |
| 32304394 | Complications on the intensive care units include acute respiratory distress syndrome, acute cardiac- and kidney injury as well as shock.Here, we present the first case report of a successful treatment of a COVID-19 patient presenting with ARDS plus refractory combined cardiogenic and vasoplegic shock, which could be successfully stabilized after implantation of a percutaneous ventricular assist device (pVAD) plus an extracorporeal membrane oxygenation (ECMO). […] While such intense treatment might not be feasible in case of a health care disaster as described for the hot spots of the COVID-19 pandemic, it might encourage treatment of younger patients on intensive care units not overcrowded by critically ill patients. | 2020-05-15 |
| 32304395 | The outbreak of novel coronavirus (SARS-CoV-2) that causes the respiratory illness COVID-19 has led to unprecedented efforts at containment due to its rapid community spread, associated mortality, and lack of immunization and treatment. […] Through treatment targeting hyperinflammation, he recovered from critical COVID-19 respiratory failure and required only 160 hours of VV-ECMO support. | 2020-05-30 |
| 32304402 | In our critical cases, eight patients with relative volume of normal lung density smaller than 40% received mechanical ventilation for supportive treatment, and two of them had died. | 2020-04-23 |
| 32304435 | Currently, there is no specific treatment or approved vaccine against COVID-19 and many clinical trials are currently investigating potential medications to treat COVID-19. […] The immunosuppressed status of some cancer patients (whether caused by the disease itself or the treatment) increases their risk of infection compared with the general population. | 2020-05-29 |
| 32304577 | The incidence of venous thromboembolism among COVID-19 patients in intensive care units appears to be somewhat higher compared to that reported in other studies including such patients with other disease conditions. […] Preliminary data show that in patients with severe COVID-19, anticoagulant therapy appears to be associated with lower mortality in the subpopulation meeting sepsis-induced coagulopathy criteria or with markedly elevated d-dimer. | 2020-05-04 |
| 32304643 | A significant increase is expected in the number of imaging studies ordered for the initial diagnosis and treatment follow-up of cases of COVID-19. | 2020-05-01 |
| 32304747 | For these reasons ARB therapy must be continued for patients affected by hypertension, diabetes and renal disease, comorbidities of the current COVID-19 pandemic. […] Controlled clinical studies should be conducted to determine whether ARBs may be included as additional therapy for COVID-19 patients. | 2020-05-20 |
| 32304772 | Earlier identification, more intensive surveillance, and appropriate therapy should be considered in patients at high risk. | 2020-05-28 |
| 32304822 | None required antiviral therapy. | 2020-05-20 |
| 32304970 | Reprocessing PPE must consider material composition, functionality post treatment, along with appropriate disinfection. | 2020-05-27 |
| 32305025 | Epidemiological data and laboratory and imaging results were collected on the first day of admission, and analyzed based on the Diagnosis and Treatment Guideline for COVID-19 (5th edition, China). | 2020-05-27 |
| 32305181 | Prevention, diagnosis and treatment of malnutrition should therefore be routinely included in the management of COVID-19 patients. | 2020-05-31 |
| 32305359 | The coronavirus-19 (COVID-19) pandemic poses a significant risk to patients undergoing hematopoietic stem cell transplantation (HCT) or cellular therapy. […] The American Society for Transplantation and Cellular Therapy Pharmacy Special Interest Group Steering Committee aims to provide pharmacy practice management recommendations for how to transition clinical HCT or cellular therapy pharmacy services using telemedicine capabilities in the inpatient and outpatient settings to maintain an equivalent level of clinical practice while minimizing viral spread in a high-risk, immunocompromised population. […] In addition, the Steering Committee offers clinical management recommendations for COVID-19 in HCT and cellular therapy recipients based on the rapidly developing literature. | 2020-05-29 |
| 32305401 | Based on the anti-inflammatory benefits of the upregulation of the ACE2/Ang1-7/Mas axis and previously demonstrated benefits of lung function improvement in SARS-CoV infections, we hypothesize that the benefits of treatment with renin-angiotensin system inhibitors in SARS-COV2 may outweigh the risks and at the very least should not be withheld. | 2020-04-21 |
| 32305585 | In the present report, we have summarized a broad institutional consensus focusing on evaluation and recommended empirical therapy for COVID-19-positive patients. | 2020-05-16 |
| 32305587 | Although several drugs have been proposed as treatment options, there are no data on the effectiveness and safety of post-exposure prophylaxis (PEP) for COVID-19. | 2020-04-29 |
| 32305589 | The article emphases the possible drug candidates in the treatment of COVID-19 infection. | 2020-04-24 |
| 32305831 | Comorbidities, in particular, diabetes and hypertension, clearly associated with age, besides obesity and smoke, are strongly associated with the need for intensive treatment and a dismal outcome. […] We made a flash survey on COVID-19 incidence and severity among children on anticancer treatment. […] We also discuss preventive measures that are in place or should be taken and treatment options in immunocompromised children with COVID-19. […] While we should not underestimate the risk of developing a more severe course of COVID-19 than that observed here, the intensity of preventive measures should not cause delays or obstructions in oncological treatment. | 2020-05-29 |
| 32305989 | We do not recommend therapy for smoldering myeloma patients (standard or high risk). […] Screening for COVID-19 should be done in all patients before therapy. […] Patients on current maintenance should continue their therapy. | 2020-05-16 |
| 32306015 | The application of “Internet+medical treatment” in community medical institutions and synergy among various institutions should be promoted. | 2020-04-22 |
| 32306118 | This study provides a brief and precise review of the current knowledge regarding COVID-19, including disease transmission, clinical characteristics, diagnosis, and potential treatment. | 2020-04-30 |
| 32306408 | To assess the capacity of intensive care units (ICUs) in Australia to respond to the expected increase in demand associated with COVID-19. | 2020-05-31 |
| 32306491 | While some information is available, further studies are imperative for a more cohesive understanding of the cardiac pathophysiology in COVID-19 patients to promote more informed treatment and, ultimately, better clinical outcomes. | 2020-04-19 |
| 32306513 | Eventually, she adhered to guselkumab treatment. […] The compliance was excellent, significant improvements were observed after only 3 months of treatment, without adverse effects. […] In agreement with current Italian recommendations, risk and benefits profile was discussed with the patient’s legal tutor and the decision to continue the treatment was taken. | 2020-04-29 |
| 32306597 | Provided strict adherence to the epidemic prevention standards formulated by the state and professional societies, it is necessary to carry out clinical diagnosis and treatment as soon as possible. | 2020-04-20 |
| 32306616 | The prevention and treatment of coronavirus disease 2019 (COVID-2019) has reached the critical stage in China. | 2020-04-20 |
| 32306657 | Objective: To investigate the clinical features and outcome of treatment for novel coronavirus pneumonia. Methods: Literature on novel coronavirus pneumonia was retrieved from PubMed and EMBASE databases. […] Mechanical ventilation (13.4%), extracorporeal membrane oxygenation (1.9%), and continuous renal replacement therapy (3.8%) were used in severe cases. | 2020-04-20 |
| 32307014 | Therefore, the People’s Liberation Army Professional Committee of Critical Care Medicine and Chinese Society on Thrombosis and Hemostasis grouped experts from the frontline of the Wuhan epidemic to come together and develop an expert consensus on diagnosis and treatment of coagulation dysfunction associated with a severe COVID-19 infection. […] This consensus includes an overview of COVID-19-related coagulation dysfunction, tests for coagulation, anticoagulation therapy, replacement therapy, supportive therapy and prevention. | 2020-04-23 |
| 32307151 | The document provides clinical recommendations for the noninvasive respiratory support (noninvasive ventilation, high flow oxygen therapy with nasal cannula) in any patient with suspected or confirmed presentation of COVID-19 with acute respiratory failure. | 2020-05-21 |
| 32307215 | We found that approximately two-thirds of elective major uro-oncologic surgeries can be safely postponed or changed to another treatment modality when the availability of health care resources is reduced. | 2020-04-22 |
| 32307245 | Despite the worsening trends of COVID-19, no drugs are validated to have significant efficacy in clinical treatment of COVID-19 patients in large-scale studies. […] The roles of teicoplanin (which inhibits the viral genome exposure in cytoplasm) and monoclonal and polyclonal antibodies in the treatment of SARS-CoV-2 are under investigation. | 2020-05-02 |
| 32307298 | Timely diagnosis and treatment may be lifesaving. […] OBJECTIVE: To raise awareness about the importance of early diagnosis and treatment of HLH with neurological involvement to prevent serious complications and demise. | 2020-04-23 |
| 32307313 | Overall treatment time is an important factor of local recurrence and indirectly of distant evolution, namely in case of protracted treatments. […] The models used to compensate the total dose in case of temporary treatment interruption are well known but it is of importance in that pandemic context to update and homogenize clinical practice in order to improve local control without increasing normal tissue complications. | 2020-04-26 |
| 32307319 | The contribution of community pharmacists in these facilities to manage chronic conditions and promote medication adherence during this COVID-19 pandemic will be essential in easing the burden on already strained health systems. | 2020-04-23 |
| 32307516 | Little is known about treatment options to combat the novel virus, but the same applies to the effects of COVID-19 on people’s mental health. | 2020-04-30 |
| 32307550 | Here, we investigated the clinical, cytokine levels, T cell proportion and related gene expression occurring in COVID-19 patients on admission and after intial treatment. 11 patients diagnosed as COVID-19 with similar initial treatment regimen were enrolled in the hospital. […] IL-10 level was significantly varied with disease progression and treatment. […] The decreased T cell proportions were observed in COVID-19 patients especially in severe cases, and all elevated to normal in mild patiens after initial treatment but only CD4+T cells return to normal in severe cases. […] The number of DEGs increased with the disease progress, and decreased after initial treatment. […] Our findings show a decreased T cell proportion with down-regulated gene expression related to T cell activation and differentiation were occurred in COVID-19 severe patients, which may help to provide effective treatment strategies for COVID-19 . | 2020-04-30 |
| 32307593 | In the present article, we have summarized the promising drugs, adjunctive agents, respiratory supportive strategies, as well as circulation management, multiple organ function monitoring and appropriate nutritional strategies for the treatment of COVID-19 in the ICU based on the previous experience of treating other viral infections and influenza. | 2020-04-23 |
| 32307653 | The expressive number of deaths and confirmed cases of SARS-CoV-2 call for an urgent demand of effective and available drugs for COVID-19 treatment. | 2020-05-29 |
| 32307905 | The same disruptions can affect management of this vulnerable patient group, perhaps warranting early aggressive treatment. | 2020-04-29 |
| 32307955 | However, hemodialysis patients represent a unique group of patients, mostly elderly and immunocompromised, for whom dialysis is a life-saving treatment which cannot be stopped. | 2020-04-21 |
| 32308263 | The relevance of these interventions for the prevention and treatment of CoViD-19 is discussed. | 2020-04-23 |
| 32308494 | The patients received the following treatments: antiviral therapy (100%), Chinese medicine (76.92%), antibiotics (50%), gastric mucosal protection (19.23%), immunotherapy (7.69%), and glucocorticoids (3.85%). […] Most patients (25/26) required ≥1 treatment. | 2020-04-23 |
| 32308732 | Compound quercetin, luteolin, kaempferol, acacetin etc., were all involved in the treatment of various disease stages on the compound level both in generality and individuality. […] The CMs of ISRD improved patients’ recovery, suggesting the importance of regulating intestinal function and keeping microenvironmental balance in TCM treatment of NCP. | 2020-04-23 |
| 32309679 | Here we have provided a foundation for cardiovascular and cardio-oncology physicians who are on the frontline providing care to COVID-19 patients, so that they can better understand the emerging cardiovascular epidemiology of COVID-19, as well as the biological rationale for the clinical trials that are ongoing for the treatment of COVID-19 patients. | 2020-05-31 |
| 32309809 | The purpose of the current systematic review is to evaluate the efficacy of antiviral therapies in treatment of COVID-19. […] In addition, clinical trials on the efficacy of antiviral therapies in the management of Severe Acute Respiratory Syndrome coronavirus (SARS-Cov) or Middle East Respiratory Syndrome coronavirus (MERS-CoV) have also been reviewed, in order to identify potential treatment options for COVID-19. […] Only one clinical trial on the efficacy of antiviral therapy in management of COVID-19 was found. […] The results depicted that adding Lopinavir-Ritonavir to the standard treatment regimen of patients with severe COVID-19 has no benefits. […] The current evidence impede researchers from proposing an appropriate antiviral therapy against COVID-19, making the current situation a serious concern for international organizations such as World Health Organization (WHO). | 2020-04-23 |
| 32309812 | Among the introduced treatment methods for management of ARDS patients, prone position can be used as an adjuvant therapy for improving ventilation in these patients. | 2020-04-23 |
| 32310190 | No antiviral therapies or vaccines are available for their treatment or prevention. | 2020-05-27 |
| 32310621 | In this review, we summarize epidemiologic, clinical and diagnostic findings, as well as treatment and prevention options for common circulating and novel CoVs infections in humans with a focus on infections in children. | 2020-04-24 |
| 32310920 | The integrated clinical, laboratory and ultrasound approach is essential for the diagnosis, monitoring and evaluation of the patient’s therapy in COVID-19 pneumonia. | 2020-04-22 |
| 32310921 | If this, on one hand, results in reducing improper access to the ER and hospital, on the other hand it substantiates the risk of underestimating problems not connected to COVID-19, such as an increased delay in the diagnosis and treatment of acute myocardial infarction and other cardiovascular emergencies. | 2020-04-22 |
| 32311114 | Therapeutic decisions need, more than ever before, to be considered in the best interests of both patients, and society, while not denying function-preserving/restoring treatment. […] Immunoglobulin therapy and plasma exchange, for those treated outside of the home, expose patients to the hazards of hospital or outpatient infusion centers. […] Steroid therapy initiation and continuation pose increased infectious risk. […] Immunosuppressant therapy similarly becomes highly problematic, with the risks of treatment continuation enhanced by uncertainties regarding duration of the pandemic. | 2020-04-24 |
| 32311151 | The government should take emergent and effective measures to prevent and treatment of the pandemic disease. | 2020-05-22 |
| 32311437 | COVID-19 diagnostic criteria: according to China’s ⟪pneumonia diagnosis and treatment Program of novel coronavirus infection (trial version 7) ⟫, in accordance with the relevant epidemiological and clinical manifestations, nasopharyngeal swabs real-time fluorescence RT-PCR detection of 2019-nCoV nucleic acid positive, COVID-19 cases were divided into mild, ordinary, severe and severe [1]. […] RESULTS: | 132 the results of 2019-nCoV nucleic acid test of various biological samples during the treatment of confirmed COVID-19 cases are as follows: the positive rate of 2019-nCoV nucleic acid test of nasopharyngeal swab is 38.13% (180/472 times), the positive rate of 2019-nCoV nucleic acid test of sputum is 48.68% (148/304 times), the positive rate of blood 2019-nCoV nucleic acid test is 3.03% (4/132 times), and the positive rate of 2019-nCoV nucleic acid test of feces is 9.83% (24/244 times). […] Simple detection of nasopharyngeal swab 2019-nCoV nucleic acid detection positive rate is not high, multi-sample 2019-nCoV nucleic acid detection can improve the accuracy, reduce the false negative rate, better guide clinical treatment and evaluate the therapeutic effect. | 2020-05-13 |
| 32311448 | In addition, many patients receiving antithrombotic therapy for thrombotic disease may develop COVID-19, which can have implications for choice, dosing, and laboratory monitoring of antithrombotic therapy. | 2020-04-23 |
| 32311643 | Oncologists need to preserve the continuum of care of patients, as the benefit of ensuring a well-delivered anti-cancer treatment plan outweighs the risk of COVID-19 infection. | 2020-05-29 |
| 32311668 | Indeed, this test represents an important immunological tool aimed at identifying the precise phase of the infection in order to undertake a more appropriate pharmacological treatment. | 2020-05-28 |
| 32311760 | In both experiments, the measured titre of SARS-CoV-2 was below the limit of detection following treatment with riboflavin and UV light. | 2020-05-14 |
| 32311826 | In addition to its central role in the diagnosis of COVID-19 infection, the clinical laboratory provides critical information to clinicians regarding prognosis, disease course, and response to therapy. | 2020-04-20 |
| 32311843 | A large number of these patients end up in the intensive care units (ICU) with critical illness requiring mechanical ventilation. | 2020-04-20 |
| 32312025 | Computed tomography (CT) has been described as a diagnostic modality in the COVID-19 diagnosis and treatment plan. | 2020-04-21 |
| 32312064 | Here, we report a family cluster case of a father and a son diagnosed as COVID-19 at our hospital, and described the clinical manifestations, laboratory results, CT changes, diagnosis and treatment strategy of these two patients. […] Focus on the value of these two methods in the diagnosis and treatment of diseases, as well as their respective deficiencies. […] For patient 1 (father), the efficacy of RT-PCR is not satisfactory either in terms of diagnosis or follow-up, which may cause misdiagnosis and delay treatment. | 2020-04-21 |
| 32312163 | The medical complexity of head and neck cancer management may lead to prolonged delays that worsen treatment outcomes. | 2020-04-21 |
| 32312290 | Two patient groups were simulated (50,000 patients in each group); (1) Patients received tPA immediately upon diagnosis of ARDS and (2) patients received standard therapy for ARDS. | 2020-04-23 |
| 32312363 | Among the 115 children, 3 were critically ill, among whom 1 had been cured and the other 2 were under continuous treatment. | 2020-04-22 |
| 32312365 | Based on a literature review, this article discusses the possible cardiovascular system damage caused by SARS-CoV-2 in children and related mechanisms, in order to provide help for the timely treatment and prevention of cardiovascular system damage caused by SARS-CoV-2 in children. | 2020-04-22 |
| 32312544 | We provide treatment advice as a pragmatic perspective on the risk/benefit ratio in specific clinical scenarios. | 2020-05-28 |
| 32312567 | We could also face major issues in referring patients with acute mental disorders to intensive care units. | 2020-05-08 |
| 32312568 | The Chinese government has formally set COVID-19 in the statutory notification and control system for infectious diseases according to the Law of the People’s Republic of China on the Prevention and Treatment of Infectious Diseases. […] Based on our own experience and the guidelines on the diagnosis and treatment of COVID-19 (7th Version) with other regulations and literature, we describe our experience with suggestions for medical practices for burn units during the COVID-19 outbreak. | 2020-04-23 |
| 32312600 | The document provides clinical recommendations for the noninvasive respiratory support (noninvasive ventilation, high flow oxygen therapy with nasal cannula) in any patient with suspected or confirmed presentation of COVID-19 with acute respiratory failure. | 2020-04-21 |
| 32312892 | For patients already enrolled however, there are challenges in continuing treatment on trial. | 2020-05-21 |
| 32312919 | Therefore, determining the algorithm becomes crucial for qualifying patients for surgical treatment, but also to stratify the risk of personnel being infected during surgery and to adequately protect staff. | 2020-04-22 |
| 32313463 | Treatment is largely supportive, with regimens including antiviral therapy. | 2020-04-23 |
| 32313660 | To date, the anti-malaria drug hydroxychloroquine found to be a treatment option for SARS-CoV-2. […] In addition to supportive treatment, such as oxygen supply in moderate cases and extracorporeal membrane oxygenation in critically ill patients, unique medications for this condition are also under investigation. […] Here we reviewed the antibody therapy might be an immediate strategy for emergency prophylaxis and SARS-CoV-2 therapy. | 2020-05-31 |
| 32313662 | Lopinavir/ritonavir was given; continuous renal replacement therapy was also introduced. […] Treatment of severe pneumonia in COVID-19 by ECMO should recognize lung plasticity considering time to ECMO introduction and interstitial biomarkers. | 2020-04-23 |
| 32313713 | The infusion management group optimized the intravenous infusion workflow based on Hamer’s Process Reengineering Theory and applied it to the treatment of patients with coronavirus disease 2019. | 2020-04-23 |
| 32313823 | Presently, there is no specific treatment or vaccine but physicians are battling with the use of antibiotics, steroid, anti-viral and anti-HIV drugs and some of the infected cases are testified improved. | 2020-04-23 |
| 32313824 | No Food and Drug Administration approved treatment is available till date. […] In this review, we are tried to explore the epidemiology, pathogenesis and current treatment of CoVs infection. […] The promising therapeutics molecules against CoVs and future prospective have been also discussed which will be helpful for researchers to find out the new molecules for the treatment of CoVs disease. | 2020-04-23 |
| 32313880 | Since Louis Pateur who developed a vaccine against rabies in 1885, in general a series of “specific” vaccines have been used for treatment of viral infection, mainly because antibiotics in general are ineffective for treatment of viral infection. […] Thus, as alternative potentially more direct “broad-spectrum” COVID-19 therapeutics, several natural and synthetic PAK1-blockers such as propolis, melatonin, ciclesonide, hydroxy chloroquine (HQ), ivermection, and ketorolac, which are readily available in the market, are introduced here. | 2020-04-23 |
| 32313883 | In one human study, it was found that the treatment of severe H1N1 influenza‑related pneumonia with rapamycin and steroids improved the outcome. […] The inhalation of buformin or phenformin for influenza may be an effective novel treatment strategy that would limit the risk of systemic side-effects associated with biguanides due to the low inhaled dose. | 2020-05-01 |
| 32313885 | Here we have provided a foundation for cardiovascular and cardio-oncology physicians who are on the frontline providing care to COVID-19 patients, so that they can better understand the emerging cardiovascular epidemiology of COVID-19, as well as the biological rationale for the clinical trials that are ongoing for the treatment of COVID-19 patients. | 2020-05-22 |
| 32314010 | The patient was treated with antiviral agents (lopinavir/ritonavir), and treatment with cDMARDs was discontinued except hydroxychloroquine. | 2020-05-04 |
| 32314034 | With no proven vaccination or treatment, infection control measures are paramount. | 2020-04-30 |
| 32314081 | I submit that attention to COVID-19 pharmacologic therapy needs similar emphasis, including identifying any existing medications that can be repurposed to treat COVID-19 patients. | 2020-05-01 |
| 32314460 | COVID-19 is a challenge for the treatment of dermatologic patients, either with severe inflammatory disorders or with skin cancer. […] The consequences for systemic treatment are obvious but it will be most important to collect the clinical data for a better decision process. | 2020-05-22 |
| 32314483 | One of question is if psoriasis patients treated with immunomodulating and immunosuppressive drugs have to discontinue their treatment in the midst of fears for the infection and its consequences. | 2020-05-22 |
| 32314698 | Hydroxychloroquine (HCQ) has been used for the treatment of novel coronavirus disease (COVID-19) cases. […] Considering the significantly increased use of HCQ during the COVID-19 pandemic, this case alerts us to the potential for HCQ to be associated with hepatotoxicity and the need to monitor liver function during HCQ therapy. | 2020-04-21 |
| 32314799 | Tocilizumab is an interleukin-6 (IL-6) receptor antibody and is progressing as a viable and promising treatment option in patients with severe coronavirus disease 2019 (COVID-19). | 2020-05-12 |
| 32314850 | Focussing on immune regulators has treatment implications for covid-19 and other viral infections. | 2020-05-19 |
| 32314951 | We highlight the critical roles that pharmacists have related to sustaining and advancing the changes being made in the face of the current COVID-19 pandemic to ensure that patients have more seamless and less complex access to treatment. | 2020-04-24 |
| 32315171 | The recent outbreak of novel coronavirus disease-19 (COVID-19) calls for and welcomes possible treatment strategies using drugs on the market. | 2020-05-07 |
| 32315386 | He was given antibiotics for infection of unknown source, subsequently refined to treatment for community-acquired pneumonia. […] Despite active treatment, he deteriorated with oxygen desaturation and tachypnoea. | 2020-04-30 |
| 32315487 | Autoimmune phenomena exist in COVID-19 subjects, and the present results provide the rationale for a strategy of preventing immune dysfunction and optimal immunosuppressive therapy. | 2020-05-14 |
| 32315614 | Novel coronavirus (COVID-19) is highly infectious and requires early detection, isolation, and treatment. | 2020-05-30 |
| 32315723 | Additionally, the origin of COVID-19 has not been determined and no specific antiviral treatment or vaccine is currently available. | 2020-05-16 |
| 32315725 | Our findings may shed light on early warning of high risks of mortality and help early intervention and treatment of COVID-19. | 2020-04-26 |
| 32315817 | ARDS and ACI may be the main obstacles for patients to treatment recovery. | 2020-05-27 |
| 32315874 | Drawing on the 9/11 experience, we highlight effective prevention measures, likely short and long-term treatment needs, vulnerable subgroups, and important points of divergence between 9/11 and the COVID-19 pandemic. […] Mental health monitoring, early identification of at-risk individuals, and treatment irrespective of financial barriers are essential for minimizing chronic distress. | 2020-05-19 |
| 32315948 | A type 1 diabetes patient experienced remission associated with chloroquine therapy while travelling to a malaria-endemic area. | 2020-05-27 |
| 32315980 | However, it has been speculated that overactive immune response could drive clinical deterioration and, based on this hypothesis, several immunosuppressants are currently being tested as potential treatment for COVID-19. […] This report supports the putative role of immunosuppressive therapy in COVID-19 affected patients. | 2020-05-26 |
| 32316065 | Concomitant venous thromboembolism (VTE), a potential cause of unexplained deaths, has been frequently reported in COVID-19 cases, but its management is still challenging due to the complexity between antithrombotic therapy and coagulation disorders. | 2020-05-06 |
| 32316233 | Glucose-6-Phosphate Dehydrogenase (G6PD) deficiency screening test is essential for malaria treatment, control, and elimination programs. […] G6PD deficient individuals are at high risk of severe hemolysis when given anti-malarial drugs such as primaquine, quinine, other sulphonamide-containing medicines, and chloroquine, which has recently been shown to be potent for the treatment of coronavirus disease (COVID-19). […] Given the challenges associated with G6PD deficiency, it would be essential to improve access to G6PD deficiency POC testing to facilitate administration of sulphadoxine-pyrimethamine to pregnant women, full implementation of the malaria control program in Ghana, and treatment of COVID-19 patients with chloroquine in malaria-endemic countries. | 2020-05-29 |
| 32316618 | The purpose of this review is to provide a comprehensive update on the pathogenesis, clinical aspects, diagnosis, challenges and treatment of SARS-CoV-2 infections. | 2020-05-29 |
| 32316712 | The aims were to investigate medical needs of lung cancer patients and their mental health status during the epidemic periods, so as to provide rational recommendations for subsequent diagnosis and treatment. […] Of the 368 patients, 18 patients were excluded as they didn’t receive anti-tumor treatment, and 350 patients were included in the final analysis. 229 cases were treated with oral targeted drugs, and 121 cases were treated with chemotherapy or immunotherapy. […] 41.3% of patients treated with intravenous chemotherapy or immunotherapy experienced treatment discontinuation, and the proportion of treatment discontinuation in chemotherapy or immunotherapy was higher than those treated with oral targeted drugs (21.0%). […] 26.6%-28.9% of patients have changed their treatment plans through online consultation. | 2020-05-16 |
| 32316718 | A systematic search on PubMed, Pedro and Google Scholar was performed using the search terms: “Covid-19”, “Coronavirus”, “severe acute respiratory syndrome coronavirus 2”, “rehabilitation”, “physical therapy modalities”, “exercise”, “occupational therapy”, and “late complications”. | 2020-04-22 |
| 32316751 | There is currently no effective treatment or approved vaccine, so isolating the source of infection and blocking the routes of transmission is important. | 2020-04-22 |
| 32316872 | Timely and appropriate public health interventions addressing cultural impact and risk for stigmatization along with proper screening, treatment, and follow up for affected individuals and close contacts can reduce the number of infections, serious illness, and deaths. | 2020-05-27 |
| 32317153 | Drugs are the main treatment of COVID-19 patients. […] According to COVID-19 prevention and control policy and requirements, combined with series of diagnosis and treatment plans, pharmacists in the first provincial-level COVID-19 diagnosis and treatment unit in Jilin Province in Northeast China have established the management practices of drug supply and pharmaceutical care from four aspects: personnel, drugs supply management, off-label drug use management and pharmaceutical care. […] So far, no nosocomial infections and medication errors have occurred, which has stabilized the mood of the staff and boosted the pharmacists’ confidence in fighting the epidemic. […] For the treatment of COVID-19, pharmacists conducted adverse reaction monitoring and participated in the multidisciplinary consultation of COVID-19. | 2020-04-24 |
| 32317180 | Immunosuppressant reduction and low-dose methylprednisolone therapy. […] After a longer time of virus shedding (28.4 ± 9.3 vs 12.2 ± 4.6 d in the control group) and a longer course of illness (35.3 ± 8.3 vs 18.8 ± 10.5 d in the control group), nine of the 10 transplant patients recovered successfully after treatment. […] Findings from this small group of cases may have important implications for the treatment of COVID-19 pneumonia in immunosuppressed populations. […] Immunosuppressed transplant recipients with coronavirus disease 2019 infection had more severe pneumonia, but most of them still achieved a good prognosis after appropriate treatment. | 2020-05-28 |
| 32317202 | Hence, there is an urgent requirement for conducting academic research on several aspects of this highly contagious disease, to find effective means of containment and treatment of the disease, for now, and in future. | 2020-04-24 |
| 32317205 | In the current paper, we describe our successful treatment of three COVID-19 pneumonia patients cases including severe cases and cases with mortality risk factors. | 2020-04-24 |
| 32317220 | Several efforts are currently made to find a treatment for COVID-19 patients. […] The anti-viral aspect of immunosuppressants towards a variety of viruses has been known since long time and it is herein discussed in the view of searching for a potential treatment for SARS-CoV-2 infection. | 2020-04-24 |
| 32317225 | He was successfully treated in the intensive care unit with mechanical ventilation and extracorporeal membrane oxygenation for respiratory support; and antiretroviral treatment with lopinavir/ritonavir. | 2020-04-24 |
| 32317267 | Epidemiological, clinical, and laboratory characteristics and treatment and outcomes data were obtained through data collection forms from electronic medical records, and the relation between clinical data and disease severity was analysed. 3497 respiratory, stool, serum, and urine samples were collected from patients after admission and evaluated for SARS-CoV-2 RNA viral load. | 2020-04-24 |
| 32317402 | Our current treatment protocol appears to be associated with favorable outcomes, but longer follow-up of a larger cohort of patients is needed. | 2020-05-30 |
| 32317408 | In the absence of approved marketed drugs against coronaviruses, the treatment and management of this novel CoV disease (COVID-19) worldwide is a challenge. | 2020-05-06 |
| 32317557 | As COVID-19 cases surge worldwide, an urgent need exists to enhance our understanding of the role of extracorporeal membrane oxygenation (ECMO) in the management of severely ill patients with COVID-19 who develop acute respiratory and cardiac compromise refractory to conventional therapy. […] Adjunctive medication in the surviving patients while on ECMO was as follows: 4 of 5 survivors received intravenous steroids, 3 of 5 survivors received antiviral medications (Remdesivir), 2 of 5 survivors were treated with anti-interleukin-6-receptor monoclonal antibodies (Tocilizumab or Sarilumab), and 1 of 5 survivors received hydroxychloroquine.An analysis of 32 COVID-19 patients with severe pulmonary compromise supported with ECMO suggests that ECMO may play a useful role in salvaging select critically ill patients with COVID-19. | 2020-05-15 |
| 32317558 | The diagnosis was established through a remote interaction with the patient after early discharge from outpatient therapy due to upcoming traveling restrictions. | 2020-05-26 |
| 32317808 | The clinical knowledge about the course, complications and treatment of COVID-19 in children and adolescents is so far limited. | 2020-04-24 |
| 32317810 | It will help in designing a probiotic-based diet for modulation of the gut microbiome, and that could be another plausible prophylactic treatment option. […] Hence, the experiences from the clinical intervention for that region should be considered in control and treatment strategies. | 2020-04-24 |
| 32318324 | For example, treatment with iron chelator deferiprone has been shown to prolong the survival of acquired immunodeficiency syndrome (AIDS) patients. | 2020-04-24 |
| 32318325 | The objectives of this study were to analyze the clinical features of coronavirus disease 2019 (COVID-19) and evaluate the diagnosis and treatment. | 2020-04-24 |
| 32318665 | Rhesus macaque models infected with SARS-CoV-2 provided insight into the pathogenic mechanism and facilitated the development of vaccines and therapeutics against SARS-CoV-2 infection. | 2020-05-19 |
| 32318706 | The panel suggests a decision-making framework for antiviral therapy that weighs risks and benefits based on disease severity as indicated by respiratory support needs, with consideration on a case-by-case basis of potential pediatric risk factors for disease progression. […] Antiviral therapy for COVID-19 is not necessary for the great majority of pediatric patients. | 2020-05-14 |
| 32318986 | If a vaccine or a treatment is approved, we recommend a government control over its use to preserve the rights of the vulnerable and needy groups. | 2020-05-01 |
| 32319129 | While the world is facing an unprecedented pandemic with COVID-19, patients with chronic diseases need special attention and if warranted adaptation of their regular treatment plan. […] Optimal disease control of allergic, asthmatic and immunodeficient children should be sought according to usual treatment guidelines. | 2020-05-20 |
| 32319218 | In this report, we present a 77-year old patient with a heart transplant under relevant immunosuppressive therapy who was tested positive for SARS-CoV-2 after several days of dyspnoea, dry cough and light general symptoms. […] The patient received an antiviral therapy with hydroxychloroquine showing no further deterioration of the clinical state. | 2020-04-22 |
| 32319424 | Key messages include that supplemental oxygen is a first essential step for the treatment of severe COVID-19 patients with hypoxemia and should be a primary focus in resource-limited settings where capacity for invasive ventilation is limited. | 2020-04-22 |
| 32319436 | In the case of CoViD-19, we must rely on professionals: it is not the time for the anticipated treatment plan, for self-determination. | 2020-04-24 |
| 32319443 | The document, which aims to propose treatment decision-making criteria in the face of exceptional imbalances between health needs and available resources, has produced strong reactions, within the medical-scientific community, in the academic world, and in the media. | 2020-04-24 |
| 32319444 | The shortage of intensive care units (ICU) beds and ventilators for the treatment of patients with severe respiratory failure produced angst in the clinicians/intensivists who have to decide which patients admit to ICU and in which patients to implement palliative care. […] The patients not admitted to ICU due to clinical reasons and advanced stage diseases should receive a high quality palliative care, to obtain a good symptoms control (mainly dyspnea, anxiety and delirium) and to implement palliative sedation at the end of life. | 2020-04-24 |
| 32319447 | At the end of the bibliographic survey there is the current absence of evidence of efficacy in favor of vitamin D in the treatment of coronavirus infection in its various expressions. | 2020-04-27 |
| 32319971 | Due to the lack of current effective treatment and vaccine for COVID-19, screening, rapid diagnosis and isolation of the patients are essential (1, 2). | 2020-04-22 |
| 32320003 | Clinical outcomes during hospitalization, such as invasive mechanical ventilation, kidney replacement therapy, and death. […] During hospitalization, 373 patients (14.2%) (median age, 68 years [IQR, 56-78]; 33.5% female) were treated in the intensive care unit care, 320 (12.2%) received invasive mechanical ventilation, 81 (3.2%) were treated with kidney replacement therapy, and 553 (21%) died. | 2020-05-01 |
| 32320066 | All these indicate that more detailed criteria are needed for the treatment and the prevention of SARS-CoV-2 infected patients. | 2020-04-29 |
| 32320359 | Only 17.7% of respondents took prevention and 45.0% of skin injuries were treated. Innovation: This is the first cross-sectional survey to understand skin injuries in medical staff caused by PPE, which is expected to be a benchmark. Conclusion: The skin injuries among medical staff are serious, with insufficient prevention and treatment. | 2020-05-01 |
| 32320375 | Emerging infectious diseases by their nature, pose new challenges to the diagnostic-treatment-control nexus, and push our concepts of causality beyond the limits of the conventional Koch-Henle approach to aetiology. | 2020-05-29 |
| 32320381 | A poor understanding of the disease among health care workers (HCWs) may result in delayed treatment and result in the rapid spread of the infection. | 2020-05-06 |
| 32320384 | CP was also utilized for the treatment of one severe COVID-19 patient. | 2020-05-06 |
| 32320477 | As chloroquine (CHQ) is part of the Dutch Centre for Infectious Disease Control coronavirus disease 2019 (COVID-19) experimental treatment guideline, pediatric dosing guidelines are needed. | 2020-05-21 |
| 32320478 | The findings in animals are inconsistent with respect to an increase in ACE2 expression in response to treatment with ACEIs or ARBs. | 2020-05-11 |
| 32320494 | A survey was distributed to an expert panel of 37 pediatric dermatologists on the PDCRTF to assess expert opinion and current practice related to three primary domains of systemic therapy: initiation, continuation, and laboratory monitoring. […] In asymptomatic patients, continuing therapy was the most popular choice across all medications queried. […] The ultimate decision regarding initiation, continuation, and laboratory monitoring of immunosuppressive therapy during the pandemic requires careful deliberation, consideration of the little evidence available, and discussion with families. […] Consideration of an individual’s adherence to COVID-19 preventive measures, risk of exposure, and the potential severity if infected must be weighed against the dermatological disease, medication, and risks to the patient of tapering or discontinuing therapies. | 2020-05-16 |
| 32320506 | Proning has become a standard treatment in the management of patients with ARDS who have difficulty achieving adequate oxygen saturation. | 2020-05-15 |
| 32320516 | Here, we summarized the current known knowledge regarding epidemiological, pathogenesis, pathology, clinical features, comorbidities and treatment of COVID-19/ SARS-CoV-2 as reference for the prevention and control COVID-19. | 2020-05-07 |
| 32320517 | We performed a retrospective study in 2 French intensive care units (ICU) where CDU is performed as a standard of care. | 2020-05-27 |
| 32320677 | SARS-CoV-2 patient plasma inhibited HLA-DR expression, and this was partially restored by the IL-6 blocker Tocilizumab; off-label Tocilizumab treatment of patients was accompanied by increase in circulating lymphocytes. | 2020-04-24 |
| 32320825 | Currently, no specific medication is recommended to treat COVID-19 patients. […] In the current review, we summarize the existing state of knowledge about COVID-19, available medications, and treatment options. […] Favilavir is an antiviral drug that is approved in Japan for common influenza treatment and is now approved to treat symptoms of COVID-19 in China. […] Moreover, Chloroquine and hydroxychloroquine, drugs used to treat malaria and arthritis, respectively, were recommended by the National Health Commission of the People’s Republic of China for treatment of COVID-19. […] Presently, chloroquine and hydroxychloroquine are under investigation by the US Food and Drug Administration (FDA) as a treatment for COVID-19. | 2020-05-26 |
| 32321116 | Guidelines developed by experts can help all practitioners standardize their attitudes and improve the treatment of COVID-19. | 2020-04-27 |
| 32321388 | Nuanced considerations of five contingency planning strategies in response to COVID-19 are described, including COVID-19-specific precautions, visitor restrictions, physician workforce considerations, operational adjustments, and group therapy changes. | 2020-04-23 |
| 32321524 | To date, several drugs targeting RdRp enzymes are being employed for SARS-CoV-2 infection treatment. | 2020-04-27 |
| 32321530 | The CT image is used to assess the disease progress, whereas the continued two times of negative results from SARS-CoV-2 nucleic acid detection had been considered as a criterion for ending antiviral treatment. […] We compared the two COVID-19 cases with similar backgrounds and CT image repeated intervals under treatment. | 2020-04-24 |
| 32321878 | The recent clinical trial reports pertaining to the efficacy of chloroquine and hydroxychloroquine against COVID-19 albeit yet to be validated with larger clinical trials, have sparked much interest globally to evaluate whether this anti-malarial drug can be repurposed for the treatment of COVID-19. […] Based on our data obtained from an animal infection model of melioidosis (a disease caused by the bacteria Burkholderia pseudomallei), treatment with chloroquine can result in the phosphorylation and consequent inhibition of glycogen synthase kinase-3β (GSK3β). | 2020-05-08 |
| 32321905 | In late March and early April 2020, the antimalarial drug, chloroquine, has been approved as an emergency treatment for the coronavirus disease 2019 (COVID-19) in the United States and in Europe. […] Although infrequent, neuropsychiatric symptoms have been reported in patients who received chloroquine for the treatment of malaria or autoimmune diseases. […] Current pharmacovigilance study results did not suggest any potential link between the use of chloroquine and an increased risk of suicide, psychosis, confusion, and agitation, which would be informative during the emergency use of chloroquine for the treatment of COVID-19. | 2020-05-22 |
| 32322046 | The prevalence of malnutrition in elderly patients with COVID-19 was high, and nutritional support should be strengthened during treatment, especially for those with diabetes mellitus, low calf circumference, or low albumin. | 2020-04-29 |
| 32322400 | Although much is still unknown about SARS-CoV-2, the scientific research is moving at an unprecedented pace towards understanding the nature, effective control, prevention and treatment of SARS-CoV-2. […] Unfortunately, no effective treatment or therapeutic drug is available for the disease; only supportive treatment and classical intervention measures are available for confronting the SARS-CoV-2 pandemic. | 2020-04-26 |
| 32322402 | Covid-19 is so new that there is currently no specific vaccine or treatment. […] In vitro tests are also being conducted to assess the efficacy of chloroquine and hydroxychloroquine for the treatment of this epidemic, which is considered a pandemic by the WHO. | 2020-04-26 |
| 32322478 | No published treatment to date has been shown to adequately control the inflammation and respiratory symptoms associated with COVID-19, apart from oxygen therapy and assisted ventilation. […] We evaluated the effects of using high dose oral and/or IV glutathione in the treatment of 2 patients with dyspnea secondary to COVID-19 pneumonia. […] Oral and IV glutathione, glutathione precursors (N-acetyl-cysteine) and alpha lipoic acid may represent a novel treatment approach for blocking NFKappaB and addressing “cytokine storm syndrome” and respiratory distress in patients with COVID-19 pneumonia. | 2020-04-25 |
| 32322758 | Previous to the pandemic we commonly utilized total neoadjuvant therapy (TNT) with a strong preference for long course chemoradiation (LCCRT). […] In the setting of the ongoing pandemic we now mandate short course radiation therapy (SCRT). | 2020-04-26 |
| 32322988 | The general and special emergency management was optimized for the efficient treatment of COVID-19-positive patients and the staff were trained in the use of protective equipment. | 2020-04-25 |
| 32323279 | In this context, it was suspected that therapy with RAS blockers might promote transmission and complications of COVID-19 by upregulation of ACE2 expression. | 2020-05-22 |
| 32323287 | Against the background of the pandemic caused by infection with the SARS-CoV-2, the German Society for Pneumology and Respiratory Medicine (DGP e.V.), in cooperation with other associations, has designated a team of experts in order to answer the currently pressing questions about therapy strategies in dealing with COVID-19 patients suffering from acute respiratory insufficiency (ARI). […] Supply continuum for the treatment of ARIKey points have been highlighted as core statements and significant observations. […] This distinction can be taken into consideration in the differential instrumentation in the therapy of ARI.The assessment of the extent of ARI should be carried out by an arterial or capillary blood gas analysis under room air conditions and must include the calculation of the oxygen supply (measured from the variables of oxygen saturation, the Hb value, the corrected values of the Hüfner number and the cardiac output). […] If the specifications for protective equipment (eye protection, FFP2 or FFP-3 mask, gown) are adhered to, inhalation therapy, nasal high-flow (NHF) therapy, CPAP therapy or NIV can be carried out according to the current state of knowledge without increased risk of infection to the staff. […] In this situation, CPAP/NIV therapy can be administered under use of a mouth and nose mask or a respiratory helmet as therapy escalation, as long as the criteria for endotracheal intubation are not fulfilled.In acute hypoxemic respiratory insufficiency, NIV should be performed in an intensive care unit or in a comparable unit by personnel with appropriate expertise. | 2020-04-23 |
| 32323460 | Solid organ transplantation represents a field with a high demand on staff, intensive care units, and follow-up facilities. | 2020-05-10 |
| 32323646 | Hydroxychloroquine is mainly used as a therapy for autoimmune diseases. […] However, the efficacy and safety of CQ/HCQ for the treatment of COVID-19 remains to be defined. […] Indiscriminate promotion and widespread use of CQ/HCQ have led to extensive shortages, self-treatment, and fatal overdoses. | 2020-04-23 |
| 32323974 | Thus, this assay can achieve rapid and sensitive detection of anti-SARS-CoV-2 IgG in human serum and allow positive identification in suspicious cases; it can also be useful for monitoring the progression COVID-19 and evaluating patients’ response to treatment. | 2020-05-21 |
| 32324101 | The National Institute for Public Health of the Netherlands asked a group of Radiology and Vascular Medicine experts to provide guidance for the imaging workup and treatment of these important complications. | 2020-04-23 |
| 32324209 | COVID-19 was confirmed by real-time reverse transcription-polymerase chain reaction and epidemiologic, clinical, radiologic, laboratory, and drug therapy data were analyzed in all patients. | 2020-04-30 |
| 32324352 | This paper discusses the possible effects of comedication on COVID-19 and the current treatment options for this infection. […] Currently, chloroquine and remdesivir are possible treatment options. […] There is no sound evidence for either treatment. […] The treatment should be reconsidered in the event of side effects and when inferior medication for comorbidity must be prescribed because of possible interactions. […] Supportive care is at present the mainstay of the treatment. | 2020-04-28 |
| 32324357 | These challenges are the most critical in the field of intensive treatment and anesthesiology. […] One of the most important prerequisites of effective critical care treatment is preserving the involved healthcare workers from the infection, by providing them with detailed practical advices on the preventive measures and treatment strategies. | 2020-04-27 |
| 32324359 | In addition to the epidemiologic interventions aiming the deceleration of the outbreak, the early identification and the correct hospital treatment remain key issues since these may influence mortality. | 2020-04-27 |
| 32324361 | There is currently no proven effective therapy for COVID-19. […] Here we discuss the drugs most investigated for the treatment of the disease. […] However, due to the severe healthcare effects of the pandemic and the potentially fatal outcome of COVID-19 patients treated in the intensive care units, their off-label use should none-the-less be considered. | 2020-04-27 |
| 32324364 | The purpose of this summary is to present the practical aspects of anesthetic and perioperative care for patients requiring surgical treatment. | 2020-04-27 |
| 32324365 | The best treatment is early endotracheal intubation and invasive mechanical ventilation. | 2020-05-04 |
| 32324366 | In recent years, CytoSorb-haemoperfusion to remove cytokines has shown promising results in the treatment of septic shock. | 2020-04-27 |
| 32324533 | In animal experiments, estrogen treatment silences the inflammatory reactions and decreases virus titers leading to improved survival rate; it seems to be an ideal prevention and therapy against COVID-19. […] We should overcome the widespread reluctance to estrogen therapy as we have a unique estrogen formula; conjugated estrogens, or conjugated equine estrogens available under the brand name of Premarin deriving from natural sources. | 2020-04-28 |
| 32324898 | Together, the incidence of ADRs was significantly high during the treatment period. […] Moreover, the active monitoring of the CHPS system reflected ADRs during COVID-19 treatment in the real world, which provided reference for safe medication in the clinic. | 2020-05-26 |
| 32324951 | There is no effective vaccine or approved drug treatment against COVID-19 and other pathogenic coronaviruses. | 2020-05-07 |
| 32324985 | In this article, besides providing a summary of literature, we would also like to make practical recommendations which may increase the safety of healthcare providers participating in the treatment or pathological duties with COVID-19 suspected, probable and confirmed cases. | 2020-04-27 |
| 32325096 | There may be a risk of COVID-19 transmission to rescuers delivering treatment for cardiac arrest. […] The aim of this review was to identify the potential risk of transmission associated with key interventions (chest compressions, defibrillation, cardiopulmonary resuscitation) to inform international treatment recommendations. […] Data from manikin studies indicates that donning of personal protective equipment delays treatment delivery. | 2020-05-20 |
| 32325124 | This article examines three aspects of antivirals, such as hydroxychloroquine, chloroquine, and remdesvir, as they might relate to the treatment of a viral infection such as COVID-19: (i) the use of vaporization for the delivery of antivirals, with the bulk constituents having mild antiviral efficacy; (ii) the application of a marine natural product extract as opposed to a single molecule as an antiviral agent; and (iii) a counter intuitive approach to formulation that is, in part, based on delivering multiple species that fall into three categories: building blocks for the virus to accelerate replication; an energy source for the infected cell to boost its immune response; and the species that antagonize or provide toxicity to the virus. | 2020-04-28 |
| 32325167 | Hospital palliative care is an essential part of the COVID-19 response but data are lacking. […] We identified symptom burden, management, response to treatment, and outcomes for a case series of 101 inpatients with confirmed COVID-19 referred to hospital palliative care. […] Patients spent a median [IQR] of 2 [1-4] days under the palliative care team, who made 3 [2-5] contacts across patient, family, and clinicians. […] At March 30, 2020, 75 patients had died; 13 been discharged back to team, home, or hospice; and 13 continued to receive inpatient palliative care. […] Palliative care is an essential component to the COVID-19 response, and teams must rapidly adapt with new ways of working. […] An international minimum data set for palliative care would accelerate finding answers to new questions as the COVID-19 pandemic develops. | 2020-05-11 |
| 32325252 | Lack of targeted therapy continues to be a problem. | 2020-05-31 |
| 32325767 | While novel vaccines and drugs that target SARS-CoV-2 are under development, this review provides information on therapeutics which are under clinical trials or are proposed to antagonize SARS-CoV-2. | 2020-04-27 |
| 32325888 | A large number of dentists (90%) were aware of recent changes in the treatment protocols. […] However, execution of amended treatment protocol was recorded as 61%. […] A number of dental practices have either modified their services according to the recommended guidelines to emergency treatment only or closed down practices for an uncertain period. | 2020-04-29 |
| 32326343 | While great resources are understandably being dedicated to treatment and diagnosis, more efforts could be dedicated to limit the virus spread. | 2020-05-23 |
| 32326426 | If chlorhexidine, a usual component of mouth rinse, is not efficient to kill SARS-CoV-2, the use of a mouth rinses and/or with local nasal applications that contain β-cyclodextrins combined with flavonoids agents, such as Citrox, could provide valuable adjunctive treatment to reduce the viral load of saliva and nasopharyngeal microbiota, including potential SARS-CoV-2 carriage. | 2020-05-23 |
| 32326509 | Technical and logistical issues arise when establishing such a non-standardized treatment into clinical practice with safety and proper governance. | 2020-04-24 |
| 32326602 | This constant transmission of a novel coronavirus and its ability to spread from human to human have prompted scientists to develop new approaches for treatment of COVID-19. […] Here, we systemically discuss the pharmacological therapeutics targeting RNA-dependent RNA polymerase (RdRp), proteinase and S protein for treatment of SARS-CoV-2 infection. […] In addition, we will discuss the viability and challenges in targeting RdRp and proteinase, and application of natural product quinoline and its analog chloroquine for treatment of coronavirus infection. | 2020-05-23 |
| 32326671 | This article aims to propose a treatment algorithm for the management of traumatic spine fracture during the COVID-19 pandemic. | 2020-04-24 |
| 32327245 | The combinations with GGOs could be useful in the identification and differential diagnosis of COVID-19, alerting clinicians to isolate patients for prompt treatment and repeat RT-PCR tests until the end of incubation. | 2020-04-27 |
| 32327293 | With the emergence of the COVID-19 virus and considering the lack of effective pharmaceutical treatment for it, there is an urgent need to identify safe and effective drugs or potential adjuvant therapy in this regard. | 2020-04-26 |
| 32327383 | Ultrasound, although not used in the diagnosis of COVID-19 may be utilised by practitioners at the point of care (POC) or on the intensive care units (ITUs) where rapid assessment of the lung condition may be required. | 2020-04-27 |
| 32327397 | Risks of treatment include QT segment prolongation, Torsades de Pointes (TdP), and death. | 2020-04-27 |
| 32327490 | The recommendations focus on administration of as much care as possible at home to keep people with epilepsy out of health care facilities, where they are likely to encounter COVID-19 (including strategies for rescue therapy), as well as minimization of risk of seizure exacerbation through adherence, and through ensuring a regular supply of medication. | 2020-04-24 |
| 32327746 | To mark the tenth anniversary of anti-IL-6 receptor therapy worldwide, we discuss the history of research into IL-6 biology and the development of therapies that target IL-6 signalling, including the successes and challenges and with an emphasis on rheumatic diseases. | 2020-05-29 |
| 32327870 | However, there is very scarce information on the management of thrombotic risk, coagulation disorders, and anticoagulant therapy. […] This article by the Working Group on Cardiovascular Thrombosis of the Spanish Society of Cardiology aims to summarize the available information and to provide a practical approach to the management of antithrombotic therapy. | 2020-04-24 |
| 32327904 | Many of the medications used for treatment of COVID-19 can also be associated with GI symptoms or liver injury and can be included in the differential diagnosis in these patients. | 2020-04-27 |
| 32328206 | This is particularly so for peritoneal neoplastic diseases, for which curative treatment mobilizes substantial personnel, operating room and intensive care resources. […] It is desirable to prioritize disease conditions for which cytoreduction surgery with or without associated hyperthermic intraoperative peritoneal chemotherapy (HIPEC) is the gold-standard treatment, and for which systemic chemotherapy cannot be a temporary or long-term alternative: pseudomyxoma peritonei, resectable malignant peritoneal mesotheliomas, peritoneal metastases of colorectal origin if they are resectable and unresponsive to systemic chemotherapy after up to 12 courses, first-line ovarian carcinomatosis if resectable or in interval surgery after at most six courses of systemic chemotherapy. | 2020-04-24 |
| 32328367 | This review will introduce a general overview of coronavirus and describe the clinical features, evaluation, and treatment of COVID-19 patients. | 2020-04-27 |
| 32328369 | Observational studies and therapeutic trials pertaining to COVID-19 are essential for assessing pathogenic characteristics and developing novel treatment options. | 2020-04-27 |
| 32328595 | The protocol is designed for a hospital setting and includes considerations related to dental treatment in both healthy subjects and those suspected or diagnosed with COVID-19. | 2020-04-27 |
| 32328757 | Other important measures include triaging of patients to identify those at the greatest risk of irreversible vision loss and prioritization of treatment visits over monitoring visits where possible. […] In order to limit patient exposure, ophthalmologists should refrain from using treatment regimens that require frequent monitoring. | 2020-05-21 |
| 32328850 | When it comes to treatment, specific drugs for COVID-19 have not been found at present, and taking old drugs for new use in treating COVID-19 has become an emergency method for the pandemic. | 2020-05-01 |
| 32329046 | This evidence, together with the experience of the authors in the management of patients with multiple sclerosis during the pandemic, will make it possible to offer some proposals for the treatment and follow-up of patients in this epidemiological context. […] After the literature search and our experience in the management of patients, a number of proposals for treatment are established for each drug, which must necessarily be individualised for each patient, since, in these exceptional circumstances, their peculiarities can affect the prognosis. | 2020-04-28 |
| 32329231 | A series of patients managed in the Cremona Thrombosis Center were admitted at Cremona Hospital for SARS-CoV-2 and started antiviral drugs without stopping DOAC therapy. […] Plasma samples for DOAC measurement were collected 2to 4 days after starting antiviral treatment, at 12 hours from the last dose intake in patients on dabigatran and apixaban, and at 24 hours in those on rivaroxaban and edoxaban. […] Of the 1039 patients hospitalized between February 22 and March 15, 2020 with COVID-19 pneumonia and candidates for antiviral therapy, 32 were on treatment with a DOAC. | 2020-05-06 |
| 32329246 | Prophylaxis treatment of COVID-19 patients with low molecular weight heparin (LMWH) is important to limit coagulopathy. […] In this review, we discuss the repurposing of fibrinolytic drugs, namely tissue-type plasminogen activator (tPA), to treat COVID-19 associated ARDS. tPA is an approved intravenous thrombolytic treatment, and the nebulizer form has been shown to be effective in plastic bronchitis and is currently in Phase II clinical trial. | 2020-04-24 |
| 32329275 | All articles were categorized into epidemiology, clinical diagnosis and treatment, basic research, pregnant women and children, mental health, epidemic prevention & control, and others. | 2020-04-27 |
| 32329276 | In this review we introduce these research works related to spike proteins, hoping it will provide reasonable ideas for the control of the current pandemic, as well as for the diagnosis and treatment of COVID-19. | 2020-04-27 |
| 32329404 | Early reports of potential treatment for coronavirus disease (COVID-19) have raised concerns related to pharmaceutical distribution. | 2020-04-24 |
| 32329419 | The lack of availability of approved treatment for this disease calls forth the scientific community to find novel compounds with the ability to treat it. | 2020-05-14 |
| 32329520 | No specific therapies/vaccines are yet available for the treatment of COVID-19. | 2020-05-16 |
| 32329563 | Further studies are needed to better investigate the causes of liver injury in patients with COVID-19 disease and the effect of treatment for COVID-19 on the liver. | 2020-05-31 |
| 32329659 | Concerns about the prevention and management of COVID-19 are on the rise, as it is crucial in contagious epidemics that travel and transfer of the patients be minimal for diagnosis, treatment, and follow-ups. | 2020-04-24 |
| 32329877 | Additionally, we have discussed various therapeutic strategies for COVID-19 under different categories, like the possible treatment plans with drug (antiviral drugs and anti-cytokines) therapy for disease prevention. […] Collectively, the review provides an overview of the SARS-CoV-2 infection outbreak along with the recent advancements and strategies for diagnosis and therapy of COVID-19. | 2020-04-30 |
| 32329879 | However, the current treatment options include hydroxychloroquine, tocilizumab, remdesivir, lopinavir-ritonavir (Kaletra®), and nitazoxanide. | 2020-04-30 |
| 32329881 | In this case series, we aimed to report preliminary data obtained with anti-complement C5 therapy with eculizumab in COVID-19 patients admitted to intensive care unit (ICU) of ASL Napoli 2 Nord. […] Patients were also treated with anticoagulant therapy with Enoxaparin 4000 IU/day via subcutaneous injection, antiviral therapy with Lopinavir 800 mg/day + Ritonavir 200 mg/day, hydroxychloroquine 400 mg/day, ceftriaxone 2 g/day IV, vitamine C 6 g/day for 4 days, and were on Non-Invasive Ventilation (NIV). […] All patients successfully recovered after treatment with eculizumab. […] Eculizumab has the potential to be a key player in treatment of severe cases of COVID-19. […] Our results support eculizumab use as an off-label treatment of COVID-19, pending confirmation from the ongoing SOLID-C19 trial. | 2020-04-29 |
| 32329920 | We highlight the importance of collaborative treatment decisions between the patient, family, and health-care provider, considering any geographic or institution-specific policies and precautions for COVID-19. | 2020-05-05 |
| 32329921 | We emphasize the importance of collaborative treatment decisions between the patient, family, and healthcare provider, considering any geographic- or institution-specific policies and precautions for COVID-19. | 2020-05-06 |
| 32329924 | In the context of COVID-19, cancer survivors represent a particularly vulnerable population that may be “doubly hit” by both costs of cancer treatment and financial strain imposed by the pandemic. | 2020-05-29 |
| 32329930 | Allergen-specific immunotherapy (AIT) is one of the most important treatment options for IgE-mediated allergies and is based on immunological effects on the diseased patient. | 2020-04-24 |
| 32329953 | Patients with oral cancer are susceptible often immunosuppressed due to the disease and/or the treatment received. […] Stage IV patients with oral cancer who did not receive treatment had progression of disease and an increased mortality rate compared to patients who receive treatment but did not contract COVID-19. […] The patients who received treatment and got affected with COVID-19 had a far worse impact and higher mortality rate than all other groups. […] Isolation and deferring treatment for stage IV patients with oral cancer, so as to avoid hospital visits and contraction of COVID-19, is an advisable strategy based on this model. | 2020-05-29 |
| 32329958 | Multidisciplinary conferences (MDC) are an important component of head and neck oncologic care including diagnosis, treatment, and survivorship. | 2020-05-29 |
| 32330073 | While of high utility in the management of HAPE and acute mountain sickness, systemically delivered pulmonary vasodilators and acetazolamide should not be used in the treatment of COVID-19, as they carry the risk of multiple adverse consequences including worsened ventilation-perfusion matching, impaired carbon dioxide transport, systemic hypotension and increased work of breathing. | 2020-04-24 |
| 32330124 | With the current rapid spread of COVID-19, global health systems are increasingly overburdened by the sheer number of people that need diagnosis, isolation and treatment. […] Here, we summarise community-driven approaches based on Free and Open Source scientific and medical Hardware (FOSH) as well as personal protective equipment (PPE) currently being developed and deployed to support the global response for COVID-19 prevention, patient treatment and diagnostics. | 2020-04-29 |
| 32330208 | Such major viral outbreaks demand early elucidation of taxonomic classification and origin of the virus genomic sequence, for strategic planning, containment, and treatment. | 2020-04-29 |
| 32330277 | There is no specific antiviral therapy recommended for coronavirus disease 2019 (COVID-19). […] Data presented here refer primarily to safety and lethality outcomes during treatment on day 13. | 2020-04-29 |
| 32330288 | With the developing COVID-19 pandemic, patients with inherited anaemias require specific advice regarding isolation and changes to usual treatment schedules. […] Cascading of accurate information for clinicians and patients is paramount to preventing adverse outcomes, such as patients who are at increased risk of fulminant bacterial infection due to their condition or its treatment erroneously self-isolating if their fever is mistakenly attributed to a viral cause, delaying potentially life-saving antibiotic therapy. | 2020-05-19 |
| 32330293 | This patient had recovered from the pneumonia after treatment. | 2020-04-24 |
| 32330303 | A combination of nucleic acid and IgM-IgG testing is a more sensitive and accurate approach for diagnosis and early treatment of COVID-19. | 2020-05-08 |
| 32330313 | The puerpera returned to normal after the operation and two times of throat swab COVID-19 nucleic acid test were all negative after antiviral therapy. | 2020-04-30 |
| 32330521 | Presently, no approved treatment or prophylaxis is available for COVID-19. | 2020-05-08 |
| 32330817 | Bedside clinicians abstracted daily patient data on history, treatment, and short-term course. […] We describe management and a proposed severity scale for treatment used in this hospital. 44 patients were enrolled; with incomplete information on 11. […] Patients also received lopinivir/ritonavir (82%), hydroxychloroquine (79%), and tocilizumab (12%) according to this treatment algorithm. | 2020-05-19 |
| 32330858 | The COVID-19 pandemic demands reassessment of head and neck oncology treatment paradigms. […] Additionally, novel, COVID-19-specific multilevel risks to HNC patients, HCWs and institutions, and society include: use of immunosuppressive therapy, nosocomial COVID-19 transmission, institutional COVID-19 outbreaks, and, at some locations, societal resource deficiencies requiring health care rationing. […] Until these risks are managed, we temporarily favor nonsurgical therapy over surgery for most mucosal squamous cell carcinomas, wherein surgery and nonsurgical therapy are both first-line options. | 2020-05-20 |
| 32330970 | This case report describes successful treatment of preterm labor during acute COVID-19 infection. […] Standard treatment for preterm labor may allow patients with acute COVID-19 infection to recover without the need for preterm delivery. […] · Standard treatment for preterm labor such as intravenous magnesium sulfate, antepartum steroid therapy and antibiotic prophylaxis for group B streptococcus infection were effective in this patient.. | 2020-04-24 |
| 32331217 | Here, we discuss the rationale and some important considerations about timing, criteria, and monitoring requirements for patients with COVID-19 respiratory failure requiring a CPAP treatment. | 2020-05-23 |
| 32331255 | In this context, the present review article provides a cumulative account of the recent information regarding the viral characteristics, potential therapeutic targets, treatment options, and prospective research questions. | 2020-05-29 |
| 32331343 | In addition to this first aspect, the recent evidence of an increased frequency of venous thromboembolism in patients with COVID-19 (a clinical element associated with a worse prognosis) calls the attention on the safety of treatment with testosterone, in particular in hypogonadal men with greater genetic predisposition. | 2020-04-28 |
| 32332319 | We illustrate the symptoms initiation, the laboratory test results, the imaging examination, and the treatment strategy in the duration of COVID-19 with a timeline chart. | 2020-05-06 |
| 32332765 | As these fusion proteins exhibit cross-reactivity against coronaviruses, they have potential applications in the diagnosis, prophylaxis, and treatment of SARS-CoV-2. | 2020-04-28 |
| 32333185 | We focus on multiple levels of intervention including intrapersonal, interpersonal, community, and social factors, each of which provide a reference point for understanding and elaborating on social/behavioral lessons learned from HIV prevention and treatment research. […] The investments in HIV prevention and treatment research far outweigh any infectious disease in the history of public health, that is, until now with the emergence of COVID-19. | 2020-05-26 |
| 32333196 | As we know more about the clinical and laboratory features of COVID-19, which is now accepted as a pandemic, many questions have been raised about how to manage and monitor the treatment of cancer patients. […] This article was written for a hypothetical approach in cancer patients diagnosed with COVID-19 in order to be an idea of collecting data for treatment with anti-cancer drugs that cause lymphopenia. | 2020-04-28 |
| 32333248 | In the early February, 2020, we called up an experts’ committee with more than 30 Chinese experts from 11 national medical academic organizations to formulate the first edition of consensus statement on diagnosis, treatment and prevention of coronavirus disease 2019 (COVID-19) in children, which has been published in this journal. […] With accumulated experiences in the diagnosis and treatment of COVID-19 in children, we have updated the consensus statement and released the second edition recently. […] The current version in English is a condensed version of the second edition of consensus statement on diagnosis, treatment and prevention of COVID-19 in children. […] This version of experts consensus will be valuable for better prevention, diagnosis and treatment of COVID-19 in children worldwide. | 2020-05-01 |
| 32333293 | As hospital resources and staff become more limited during the COVID-19 pandemic, it becomes critically important to define which BC patients require more urgent care and which patients can wait for treatment until the pandemic is over. […] Additionally, we provide treatment recommendations for each of these patient scenarios. […] Priority A patients have conditions that are immediately life threatening or symptomatic requiring urgent treatment. […] Priority B patients have conditions that do not require immediate treatment but should start treatment before the pandemic is over. […] Physicians should use these recommendations to prioritize care for their BC patients and adapt treatment recommendations to the local context at their hospital. | 2020-05-18 |
| 32333494 | Nevertheless, genetic factors in different ethnic groups often contribute to disease severity and treatment response. […] Finally, if a link to genetic variations in the androgen receptor and COVID-19 disease severity can be established, it would suggest new treatment options. | 2020-04-25 |
| 32333552 | Movement disorder (Parkinson’s disease, essential tremor, dystonia), neuropsychiatric disorder (obsessive compulsive disorder, Tourette syndrome, depression), and epilepsy patients can develop varying degrees of symptom worsening from interruption of therapy due to neurostimulator battery reaching end of life, device malfunction or infection. […] Similarly, patients with generalized dystonia can develop status dystonicus, patients with obsessive compulsive disorder can become suicidal, and epilepsy patients can experience potentially life-threatening worsening of seizures as a result of therapy cessation. […] The decision for replacement of the implantable pulse generator to prevent interruption of DBS therapy should be made on a case-by-case basis taking into consideration battery status and a patient’s tolerance to potential therapy disruption. | 2020-04-25 |
| 32333601 | We further hypothesized that their expression could be affected by inflammation or medication usage. […] Patients with IBD do not have higher expression during inflammation; medical therapy is associated with lower levels of ACE2. | 2020-05-14 |
| 32333823 | Corticosteroids and non-steroid immunomodulatory agents are the mainstays of treatment. […] Treatment can be challenging particularly in pemphigus, mucous membrane pemphigoid, and epidermolysis bullosa acquisita which may require more intense immunosuppressive approaches. | 2020-04-25 |
| 32333929 | Major issues for patients with ILD will include restricted access to key components of the diagnostic process, new uncertainties in the use of common ILD pharmacotherapies, limited ability to monitor both disease severity and the presence of medication adverse effects, and significantly curtailed research activities. | 2020-05-10 |
| 32334062 | There is currently no specific treatment available for patients with COVID-19 infection. […] Numerous potential therapies, including supportive intervention, immunomodulatory agents, antiviral therapy, and convalescent plasma transfusion, have been tentatively applied in clinical settings. | 2020-04-29 |
| 32334158 | The present day is dominated by studies on determining the factors that affect, taking preventive actions, and trying to find an effective treatment on top priority. | 2020-05-19 |
| 32334163 | Unani is a traditional system of medicine developed during the middle ages, which employs natural drugs of herbal, animal and mineral origin for treatment. | 2020-05-19 |
| 32334182 | To improve this, public health officials should provide a timely, clear rationale for quarantine and information about protocols; emphasise social norms to encourage this altruistic behaviour; increase the perceived benefit that engaging in quarantine will have on public health; and ensure that sufficient supplies of food, medication and other essentials are provided. | 2020-05-29 |
| 32334502 | To date, no definitive treatment orvaccine application exists for COVID-19. […] Although new investigations seek to repurpose existingantiviral treatments for COVID-19, innovative treatment strategies not normally considered tohave antiviral capabilities may be critical to address this global concern. […] One such avenue that mayprove to be exceedingly fruitful and offer exciting potential as new antiviral therapy involves themechanistic target of rapamycin (mTOR) and its associated pathways of mTOR Complex 1(mTORC1), mTOR Complex 2 (mTORC2), and AMP activated protein kinase (AMPK). […] Yet, important considerationsfor the development of safe and effective antiviral therapy with mTOR pathways exist. | 2020-05-04 |
| 32334535 | We here discuss this concern in relation to headache treatment and conclude that, based on current evidence, there is no reason to abandon treatment of headache patients with RAS inhibitors or ibuprofen. | 2020-04-28 |
| 32334800 | As the global incidence of COVID-19 disease is increasing dramatically, health systems worldwide started to suffer in terms of its capability to manage affected people and the ability to provide standard treatment for critically ill patients in a safe environment. | 2020-04-29 |
| 32334905 | In the radiotherapy department of Mulhouse hospital (France), we pointed five points out: protection of medical and paramedical staff, protection of patients undergoing treatment, detection of patients suspected of being infected by SARS-CoV-2 and their management, reorganization of the patient circuit and measures regarding the quality management. | 2020-04-28 |
| 32335097 | It has been hypothesized that DPP4 inhibition, a therapy currently available for type 2 diabetes, might represent a target for decreasing the risk of the acute respiratory complications of the COVID-19 infection but (1) lack of demonstration of SARS-CoV2 binding to DPP4 (2) possible protective role of sDPP4 in Middle East respiratory Syndrome (MERS-CoV) (3) demonstrated inhibition and downregulation of DPP4 by HIV1 and MERS-CoV and (4) not exclusive role of the receptor binding in tropism of the Coronavirus family, support that DPP4 inhibition at present doesn’t represent a plausible approach to mitigate COVID-19. | 2020-05-11 |
| 32335281 | This brief article discusses the therapeutic potential of glycyrrhizin for the treatment of COVID-19 from the perspective of its pharmacological action, including binding angiotensin-converting enzyme II (ACE2), downregulating proinflammatory cytokines, inhibiting the accumulation of intracellular reactive oxygen species (ROS), inhibiting thrombin, inhibiting the hyperproduction of airway exudates, and inducing endogenous interferon. | 2020-05-03 |
| 32335367 | We further explain the therapeutic approaches that can be taken in the treatment and prevention of this viral infection. | 2020-05-27 |
| 32335406 | These predictors would provide a new perspective on early identification of patients with prolonged viral shedding and facilitate optimal isolation protocols and treatment strategies. | 2020-05-19 |
| 32335426 | Early detection, isolation, diagnosis, and treatment are the most effective means of prevention and control. […] The current gold standard for the diagnosis of COVID-19 is the detection of coronavirus nucleic acids, but imaging has an important role in the detection of lung lesions, stratification, evaluation of treatment strategies, and differentiation of mixed infections. | 2020-05-15 |
| 32335561 | Through PubMed, we explored the relevant articles published on treatment of COVID-19 and on trials ongoing up to April 15, 2020. | 2020-04-28 |
| 32335585 | There is no proven antiviral agent against SARS-CoV-2 so the treatment for COVID-19 is symptomatic, aiming for the management of the symptoms and prevention of the complications. […] Numerous antiviral compounds used to treat other infections are being clinically researched to find possible treatment. | 2020-04-28 |
| 32335900 | Treatment times and wearer comfort were determined and compared. […] All anaesthetists accomplished the treatment objectives of all study arms without adverse events. | 2020-05-29 |
| 32336069 | Early recognition and treatment is crucial in these cases. […] Thus, it is important to know typical COVID‑19 symptoms, possible clinical manifestations, complications, and recommended treatment. | 2020-04-30 |
| 32336150 | Recommendations should be adapted to the local environment and will continue to evolve as more data become available, the shortage of testing and PPE is resolved, and a vaccine and therapeutics for COVID-19 are developed. | 2020-05-25 |
| 32336317 | This pandemic situation has forced scientists to rework strategies to combat infectious diseases through drugs, treatment, and control measures. […] COVID-19 treatment requires both limiting viral multiplication and neutralizing tissue damage induced by an inappropriate immune reaction. […] Currently, various diagnostic kits to test for COVID-19 are available, and repurposing therapeutics for COVID-19 has shown to be clinically effective. […] As the global demand for diagnostics and therapeutics continues to rise, it is essential to rapidly develop various algorithms to successfully identify and contain the virus. | 2020-04-29 |
| 32336563 | The document provides clinical recommendations for the noninvasive respiratory support (noninvasive ventilation, high flow oxygen therapy with nasal cannula) in any patient with suspected or confirmed presentation of COVID-19 with acute respiratory failure. | 2020-04-27 |
| 32336564 | These findings will facilitate the decision making regarding the patient management, both when deciding the place of admission of the patient and the type of treatment to be prescribed. | 2020-04-29 |
| 32336586 | The COVID-19 pandemic has been particularly challenging due to a lack of established therapies and treatment guidelines. […] Several antivirals, antimalarials, and biologics are being considered for treatment at this time. […] The purpose of this literature review is to synthesize the available information regarding treatment options for COVID-19 and serve as a resource for health care professionals. […] This narrative review was conducted to summarize the effectiveness of current therapy options for COVID-19 and address the controversial use of non-steroidal anti-inflammatory drugs (NSAIDs), angiotensin converting enzyme (ACE) inhibitors, and angiotensin receptor blockers (ARBs). […] PubMed and SCOPUS were queried using a combination of the keywords “COVID 19,” “SARS-CoV-2,” and “treatment.” All types of studies were evaluated including systematic reviews, case-studies, and clinical guidelines. […] Current guidelines recommend combination treatment with hydroxychloroquine/azithromycin or chloroquine, if hydroxychloroquine is unavailable, in patients with moderate disease, although these recommendations are based on limited evidence. […] Until the results of these trials become available, we must use the best available evidence for the prevention and treatment of COVID-19. | 2020-05-03 |
| 32336594 | Since containment of the outbreak may have partially failed due to asymptomatic transmission, it is imperative to accelerate the development of rapid point-of-care diagnostic tests, vaccines, and therapeutics for the COVID-19 epidemic. | 2020-04-30 |
| 32336673 | Pharmacists have successfully completed the tasks of purchase, storage, and free distribution of drugs worth ¥1.03 million (approximately $146,000), reviewed about 20,000 electronic orders, provided one-on-one online medication consultation for 484 patients, and held 5 lectures on rational drug use knowledge, which could help reduce irrational drug use and minimize the risk involved. […] They not only ensured the timely supply of the drugs but also reduced the incidence of drug-induced risks through medication review and guidance, thereby improving patient compliance and helping the patients rebuild their confidence in overcoming the disease. | 2020-04-30 |
| 32336723 | Currently, no treatment for SARS-CoV-2 are approved because of lack of evidence, but a number of clinical trials are in process and we are expecting fruitful results very soon. […] This review focuses on various approaches of treatment and few of the most recent clinical trials carried out in this field. | 2020-05-08 |
| 32336927 | This review article summarizes the developing situation surrounding the SARS-CoV-2 pandemic with respect to its epidemiology, unique genomic structure, possible origins, transmission, pathogenesis, comparison with other deadly species of Coronaviruses (CoV) and emerging treatment strategies built on informed literature. | 2020-05-22 |
| 32336959 | Due to lack of data on treatment strategies specific to this subset of patients, currently available evidence on management of the critically ill needs to be extrapolated and customized to their clinical needs. | 2020-05-06 |
| 32337113 | In this study, we will provide a brief review of viral origin, identification, symptoms, transmission, diagnosis, and potential treatment strategies for the newly identified SARS-CoV-2 strain. | 2020-04-30 |
| 32337139 | Recent findings of an open-label study that investigated the use of hydroxychloroquine and azithromycin in COVID-19 patients in Marseille, France, has garnered some optimism in scientific quarters and the general public alike in terms of finding a treatment regimen to control the rampant rise of COVID-19. […] We will discuss the potential off-label therapy and studies as it pertains to COVID-19. | 2020-04-30 |
| 32337143 | Since there is no specific therapeutic intervention nor a vaccine available against the virus, supportive management and treatment with non-specific therapeutic agents (repurposed drugs) may provide relief to the patients. | 2020-04-30 |
| 32337148 | We need more research in Covid-19 patients with cardiovascular involvement for early diagnosis, prevention of exposure to health care workers and effective treatment. | 2020-04-30 |
| 32337192 | Here, we introduce a modified treatment method for COVID-19-associated pneumonia. | 2020-04-30 |
| 32337201 | Careful acquisition of an epidemiological history is necessary to make a correct diagnosis and strategize a treatment plan. | 2020-04-30 |
| 32337328 | This work shows a patent database for Coronaviruses that provides an overview of the patenting activity and trends in focused antiviral therapy with the use of triazole based compounds, glycoprotein, and protease inhibitors as possible treatment. […] The patent data was obtained from Orbit Intelligence Software using a patent family structure to get a big database that could be used for built patent landscape report (PLR), market analysis, technical and competitive intelligence, and monitoring and survey of a new ideas for the treatment of coronavirus diseases. | 2020-04-30 |
| 32337386 | In light of the COVID-19 pandemic, hospitals and proton eye therapy facilities must analyze several factors to ensure appropriate treatment protocols for patients and provider teams. […] Practice considerations to limit COVID-19 transmission in the proton ocular treatment setting for UM are necessary. […] The Particle Therapy Co-Operative Group (PTCOG) is the largest international community of particle/proton therapy providers. | 2020-04-30 |
| 32337664 | Tocilizumab, which is the IL-6 receptor antagonist, has been approved by the US FDA for the treatment of cytokine release syndrome (CRS), is expected to treat cytokine storm caused by COVID-19 and is now in clinical trials. […] In this paper, we will elaborate the role of cytokine storm in COVID-19, the mechanism of tocilizumab on cytokine storm and the key points of pharmaceutical care based on the actual clinical application for COVID-19 in our hospital, the latest research reports, clinical trial progress of tocilizumab, drug instruction from the US FDA, and “Diagnosis and Treatment Plan of Novel Coronavirus Pneumonia (seventh trial edition)” in China, so as to provide reference for the treatment of COVID-19. | 2020-05-28 |
| 32337769 | Successful treatment of viral infections has proven to be huge challenge for modern medicine with the most effective approach being prior vaccination. […] Therefore, any treatment which can decrease the severe symptoms due to lung damage may help attenuate mortality rates. […] Noscapine, a medication used for the treatment of cough, has been shown to inhibit bradykinin enhanced cough response in man. | 2020-04-27 |
| 32337790 | The clinical course was complicated by extreme overexposure to the mammalian target of rapamycin inhibitor everolimus, following coadministration of chloroquine and lopinavir/ritonavir therapy. […] The case is illustrative for dilemmas that transplant professionals may face in the absence of evidence-based COVID-19 therapy and concurrent pressure for exploration of experimental pharmacological treatment options. […] However, the risk-benefit balance of experimental or off-label therapy may be weighed differently in organ transplant recipients than in otherwise healthy COVID-19 patients, owing to their immunocompromised status and potential drug interactions with immunosuppressive therapy. […] With this case report, we aimed to achieve increased awareness and improved management of drug-drug interactions associated with the various treatment options for COVID-19 in renal transplant patients. | 2020-05-13 |
| 32338155 | Anti-malarial medicine chloroquine (CQ) and particularly its chemical analogue hydroxychloroquine (HCQ) have been recommended as promising candidate therapeutics that are now under either compassionate off-label use or clinical trials for the treatment of COVID-19 patients. […] Given the fact that for decades HCQ has been approved as an immunomodulatory drug for the long term treatment of chronic rheumatic diseases, as experienced rheumatologists, we would like to share our thoughts in this regard and trigger a brainstorm among clinical care providers for exchanging their diverse opinions on this urgent topic. | 2020-05-05 |
| 32338164 | New treatment against SARS-CoV-2 now is a must. […] The compounds 2 and 3 may tightly bind to the SARS-CoV-2 RdRp and so may be successful in the treatment of COVID-19. | 2020-05-16 |
| 32338224 | In this framework, Gurwitz [40] proposed to use AT1R blockers, such as losartan, as a potential treatment of COVID-19 infection. […] In fact, losartan as well as olmesartan, used for treating hypertension in patients, were able to increase ACE2 expression after 28 days treatment of rats with myocardial infarction [41]. […] Then, Gurwitz suggests to evaluate severity of symptoms in COVID-19 infected patients under previous chronic treatment with AT1R blockers in comparison to COVID-19 infected patients who did not take AT1R blockers [40]. | 2020-04-27 |
| 32338298 | At present, HNC patients may be anxious and due to logistical issues, may not be adequately prepared for their treatment. […] To ensure that patients have a thorough understanding of their treatment and expected outcome during the current COVID-19 crisis there may be merit in the use of the HaNC-AD PCI. | 2020-05-08 |
| 32338708 | There are many pharmacologic therapies that are being used or considered for treatment of COVID-19. […] Develop evidence-based rapid guidelines intended to support patients, clinicians and other health-care professionals in their decisions about treatment and management of patients with COVID-19. […] The IDSA guideline panel agreed on 7 treatment recommendations and provided narrative summaries of other treatments undergoing evaluations. | 2020-05-06 |
| 32338790 | The 2019 novel coronavirus (COVID-19) pandemic has created significant challenges to the delivery of care for patients with advanced head and neck cancer requiring multimodality therapy. | 2020-05-29 |
| 32338809 | In a palliative care clinic, this apprehension gets exemplified, as these patients have limited life expectancy. | 2020-05-29 |
| 32339025 | As directors of two major academic cardiac catheterization laboratories in the city, we both have had to operationalize logistical planning of physician and staff redeployments as well as modification of our respective hospital units including conversion of large portions of the catheterization laboratory into COVID-19 intensive care units in order to deal with the surge of COVID-19 patients within the hospital. | 2020-04-27 |
| 32339235 | During the ongoing COVID-19 pandemic, contact with the healthcare system for cancer treatment can increase risk of infection and associated mortality. […] Treatment recommendations must consider this risk for elderly and vulnerable cancer patients. […] We extracted individual patient-level data (IPLD) for 1,321 patients from Kaplan-Meier curves from five randomized trials on treatment of elderly GBM patients including available subanalyses based on MGMT methylation status. […] Our simulations reveal how COVID-19-associated risks affect survival under different treatment regimens. […] In patients with methylated MGMT receiving single modality treatment, TMZ-alone treatment approaches may be an option in settings with high COVID-19-associated risk. […] Our quantitative framework can serve as a model for assessing COVID-19 risk associated with treatment across neuro-oncology. | 2020-05-06 |
| 32339248 | There is no specific antiviral therapy recommended for coronavirus disease 2019 (COVID-19). […] Data presented here refer primarily to safety and lethality outcomes during treatment on day 13. | 2020-04-30 |
| 32339250 | This approach will provide much needed insight into the underlying molecular dynamics of COVID-19 for the development of novel treatment and prevention strategies. | 2020-04-27 |
| 32339260 | We discuss how preventative and control measures implemented during the COVID-19 crisis could affect the prevalence of anaemia, and highlight issues regarding the diagnosis and treatment of anaemia in patients requiring elective or emergency surgery. | 2020-05-06 |
| 32339304 | Treatment for other viral infections in renal transplant recipients often includes a reduction in immunosuppression; however, no current guidelines are available recommending the optimal approach to managing immunosuppression in the patients who are infected with SARS-CoV-2. […] It is currently advised to avoid corticosteroids in the treatment of SARS-CoV-2 outside of critically ill patients. […] Recently published cases describing inpatient care of COVID-19 in renal transplant recipients differ widely in disease severity, time from transplantation, baseline immunosuppressive therapy, and the modifications made to immunosuppression during COVID-19 treatment. | 2020-05-26 |
| 32339340 | At the time of writing, our Government has passed emergency laws (March 11, 2020), with a view to preventing widespread viral infection among the population, which may well lead to an increase in the number of people requiring intensive care unit (ICU) hospital treatment. | 2020-04-27 |
| 32339382 | Data were collected from the clinical records using a standardised questionnaire on maternal general characteristics, any medical or obstetric co-morbidity, course of pregnancy, clinical signs and symptoms, treatment of COVID 19 infection, mode of delivery, neonatal data and breastfeeding. | 2020-05-29 |
| 32339394 | With the COVID-19 pandemic, clinicians and researchers have been suddenly confronted with the difficulty of treatment provision and continuation of clinical trials without face-to-face contact. | 2020-04-27 |
| 32340018 | The difficulties in diagnosis, infection control, and treatment of COVID-19 in maintenance HD patients are discussed in this report. | 2020-04-27 |
| 32340051 | Building a therapeutic relationship and integrating her into an outpatient clinic was possible despite her lack of insight into the illness and her rejection of medical treatment. | 2020-04-29 |
| 32340090 | Objective: To provide a system for warning, preventing and controlling emerging infectious diseases from a macroscopic perspective, using the COVID-19 epidemic data and effective distance model. Methods: The dates of hospitalization/isolation treatment of the first confirmed cases of COVID-19 and the cumulative numbers of confirmed cases in different provinces in China reported as of 23 February, 2020 were collected. | 2020-04-28 |
| 32340091 | Objective: By describing and analyzing the epidemic characteristics and trends of the attack rate, the crude mortality and relevant indexes in Hubei province during the pandemic of COVID-19 to provide comprehensive evaluations of the epidemic trends and the effects of intervention measures. Methods: Based on the case data reported in Hubei province during the COVID-19 epidemic, combined with the important time of major interventions and event, the cumulative attack rate, the sequential increase rate of new cases, baseline increase rate of new cases, the observation- confirmed case conversion rate, the cumulative crude mortality, the daily severe case rate, and the ratio of death to severe were used to describe and analyze the epidemic characteristics in different phases of the COVID-19 epidemic. Results: The epidemic experienced an outbreak phase from January 10 to February 3 with large amount of case reported, a peak phase from February 4 to February 19 with continuous increasing number of new cases and deaths, a platform phase from February 20 to March 3 with balanced diagnosis and treatment number, and a descending phase from March 4 to March 18 with decreased diagnosis and increased treatment number. | 2020-04-28 |
| 32340092 | Based on systematic review of the role of clinical treatment, disease control and scientific research, and combining with the problems exposed by the COVID-19 epidemic, suggestions were proposed to reform and improve the prevention and treatment system for major epidemics diseases in China. […] In clinical treatment, it is necessary to enhance clinical staff’s awareness of law-based reporting, capabilities of syndromic surveillance, the use of infectious diseases reporting systems, and to improve national or local monitoring platforms for emerging infectious diseases detection. […] As for scientific research in major epidemic response, it is essential to strengthen research projects guided by national requests, build research institutions that can “make a final decision”, establish national and regional key laboratories, and strengthen strategic technical reserve for emergency disease control and treatment. | 2020-04-28 |
| 32340095 | In the epidemic period, classified management of COVID-19 cases should be promoted according to needs for control and prevention of isolation and treatment for the purpose of rational allocation of medical resources. 目的： 分析广东省新型冠状病毒肺炎（COVID-19）病例的临床转归及其影响因素，为优化医疗救治及疫情防控的策略提供参考依据。 | 2020-04-28 |
| 32340096 | Objective: To explore the feasibility of direct renin inhibitor aliskiren for the treatment of severe patients of COVID-19 with hypertension. Methods: A retrospective case analysis of effectiveness and safety of aliskiren treatment to lower blood pressure in three severe and one critically ill patients of COVID-19 with hypertension. Results: Four patients, two males and two females, with an average age of 78 years (66-87 years), were referred to hospital mainly because of respiratory symptoms. […] On the basis of comprehensive therapy combined with antiviral and oxygenation treatment, aliskiren antihypertensive treatment was taken for three to four weeks. […] The condition improved, and all patients had reached the discharge standard and were discharged. Conclusion: Our preliminary clinical data shows that aliskiren’s antihypertensive therapy is effective and safe for severe COVID-19 patients complicated with hypertension. […] Further clinical aliskiren therapy study is required with more COVID-19 patients.. 目的： 探索直接肾素抑制剂阿利吉伦用于重型新型冠状病毒肺炎(COVID-19)合并高血压患者治疗的可行性。 | 2020-04-28 |
| 32340097 | Recognizing the characteristics of three diseases, especially COVID-19, and improving the disease awareness of COVID-19 will help better implement the guidelines of “scientific prevention and treatment, precise implementation” and prevent and control COVID-19. | 2020-04-28 |
| 32340120 | Thus, this special focus is an attempt to hunt down various treatment options to combat COVID-19 based on repurposing drugs that are known to have multiple antiviral properties, including against herpesvirus. | 2020-04-29 |
| 32340389 | Currently, some HIV protease inhibitors (i.e., Lopinavir) are proposed for the treatment of COVID-19, although their effectiveness has not yet been assessed. | 2020-04-29 |
| 32340531 | This review article aims to bridge this gap by briefly reviewing the key points of the evaluation and treatment of patients with COVID-19 in the ambulatory clinic environment. | 2020-04-30 |
| 32340541 | When possible, alternative diagnostic and treatment strategies should be pursued. | 2020-04-28 |
| 32340549 | The purpose of this review is to evaluate the current evidence surrounding the treatment of these patients during this pandemic and to provide evidence-based recommendations with attention to increased risk in this setting. […] Patients with head and neck mucosal malignancy require continued treatment despite the current pandemic state. […] Care must be taken at all stages of treatment to minimize the risk to patients and health care workers while maintaining focus on minimizing use of limited resources. | 2020-04-28 |
| 32340588 | Although the full repercussions of this disease have yet to be realized, the outlined recommendations will guide otolaryngologists in the treatment of pediatric patients in the face of an unprecedented global health crisis. | 2020-04-28 |
| 32340654 | Presented here is a range of information arising from related areas that have impact upon the safety and efficacy of drug therapy in the context of COVID-19. […] Issues include pharmacy practice, clinical therapeutics, and possible new treatments for the virus. | 2020-04-30 |
| 32340737 | Although highly hazardous communicable diseases like Ebola virus disease and MERS are of concern due to their mortality rates and limited treatment options, these same concepts may be applied to the early identification and isolation of patients suspected of having more common communicable diseases like measles and influenza, emphasizing the importance of protocol-based screening in the healthcare environment. | 2020-04-30 |
| 32340759 | So far, no successful specific treatment has been found for this disease. […] Altogether, we highly recommend clinicians to look after those antibiotics with anti-inflammatory activity for both empiric antibiotic therapy and reducing the inflammation to prevent septic shock in patients with diagnosed COVID-19. | 2020-04-30 |
| 32340833 | In this literature review, the causative agent, pathogenesis and immune responses, epidemiology, diagnosis, treatment and management of the disease, control and preventions strategies are all reviewed. | 2020-05-05 |
| 32341077 | Despite international efforts to identify a specific treatment, therapy remains supportive and is principally focused on optimising respiratory function. | 2020-04-28 |
| 32341142 | Compatibility of sample pre-treatment for viral neutralisation or viscous samples with the QIAstat-SARS system were also tested.The QIAstat-Dx Respiratory SARS-CoV-2 Panel demonstrated a comparable sensitivity to the WHO recommended assay with a limit of detection at 1000 copies/mL. | 2020-04-28 |
| 32341442 | Until further data are available, it is recommended that ARB and ACEI medications be continued for the treatment of patients with cardiovascular disease and hypertension, especially those at high risk, according to guideline-directed medical therapy based on the currently available evidence. | 2020-04-30 |
| 32341630 | Currently no vaccine is available and treatment is mainly supportive. | 2020-04-30 |
| 32341718 | But for Hubei Province, the subjects of Wuhan City and Hubei Province were included from the time of admission to the Huoshenshan Hospital to present day in order to ensure that all or the majority of the confirmed and suspected patients were collected for diagnosis and treatment. | 2020-05-16 |
| 32341721 | The reasons for hospitalization were: surgical treatment of cancer (n = 5), complex emergencies (n = 5), treatment of complications linked to cancer or its treatment (n = 3), gastroplasty (n = 1), and stoma closure (n = 1). | 2020-04-28 |
| 32341910 | Hydroxychloroquine and chloroquine have been used as treatment and are being considered as prophylaxis. […] Our patient developed COVID-19 while on hydroxychloroquine and although more work is needed, this calls into question the role of these medications as preventive therapy. | 2020-05-06 |
| 32342112 | We grouped FPMRS conditions into those in which virtual management differs from direct in-person visits and conditions in which treatment would emphasize behavioral and conservative counseling but not deviate from current management paradigms. | 2020-05-01 |
| 32342184 | In the current SARS-CoV-2 pandemic there are many questions regarding the safe treatment of patients with inflammatory rheumatic diseases. | 2020-05-08 |
| 32342191 | In view of the PET/CT findings, home isolation, symptom surveillance, and treatment (in 3/5 patients) were indicated. | 2020-05-28 |
| 32342479 | Of the 43 severely ill patients, 6 (14%) received high-flow nasal cannula oxygen therapy, and 1 (2.3%) received invasive mechanical ventilation. | 2020-05-07 |
| 32342541 | The MD Anderson Head and Neck Surgery Treatment Guidelines Consortium devised the following to provide guidance on triaging head and neck cancer (HNC) surgeries based on multidisciplinary consensus. […] Options for alternative treatment modalities are provided if surgical treatment needs to be deferred. | 2020-05-29 |
| 32342609 | Both patients reported clinically meaningful benefits from nVNS therapy. | 2020-05-13 |
| 32342676 | As COVID-19 has such varied clinical manifestations and case fatality rates, no standard antiviral therapy regimen has been established other than supportive therapy. | 2020-04-28 |
| 32342677 | Since clinical feature of COVID-19 has not been fully evaluated yet, empirical antibacterial agents are frequently combined for the treatment of COVID-19 in addition to antiviral agents, concerning co-existing bacterial pathogens. | 2020-04-28 |
| 32342863 | In that same scenario, postponement or interruption of radiotherapy treatment of COVID-19 positive patients is generally recommended to avoid exposure of cancer patients and staff to an increased risk of COVID-19 infection. […] Case-specific consensus recommendations regarding multimodality treatment strategies and fractionation of radiotherapy are provided. | 2020-05-29 |
| 32342870 | Under its lead, the following measures were implemented in the radiation oncology department: the radiotherapy clinic was divided into different infection control zones with varying levels of protection; special staff and patient infection control training sessions were conducted and appropriate measures deployed; daily symptom testing criteria were implemented for patients undergoing treatment; special rotating schedules and infection control methods were implemented for various staff members such as medical physicists/dosimetrists and radiation therapists; modified radiotherapy workflow and specialized treatment area cleaning and disinfection policies and procedures were designed and executed; and special medical waste disposal methods were implemented. […] We began treating patients using this new COVID-19 radiotherapy treatment workflow and infection control measures on January 30, 2020. | 2020-05-27 |
| 32342872 | We have undertaken a rapid review of published literature on the role of radiotherapy in the multimodality treatment of paediatric cancers governing the European practise of paediatric radiotherapy. […] This review provides evidence-based treatment recommendations during unexpected shortage of paediatric radiotherapy facilities. | 2020-05-27 |
| 32342878 | We performed a review of the literature, as well as national and international treatment guidelines, seeking data in support of the RADS principle (Remote visits, Avoid radiation, Defer radiation, Shorten radiation) [3] as it applies to gastrointestinal cancers. | 2020-05-27 |
| 32343013 | Treatment toxicities from radiation or chemoradiation therapy significantly increase these risks. | 2020-05-29 |
| 32343086 | As nurses in dialysis providing a life-sustaining therapy, we are required to provide an essential service during pandemics and need to thrive in the uncertainty. | 2020-04-30 |
| 32343118 | This article provides general guidance on supporting curative surgical treatment where appropriate and with available resources. | 2020-04-30 |
| 32343187 | Orthopaedic surgeons are not generally considered front-line staff in terms of the treatment of the disease that the novel coronavirus causes compared with anaesthetic and medical colleagues. | 2020-04-29 |
| 32343410 | The clinical features and treatment of pulmonary tuberculosis patients with COVID-19 is unclear and understudied. […] We provide information and experience with treatment of pulmonary tuberculosis cases with confirmed COVID-19 infection. | 2020-04-28 |
| 32343419 | Over the period of operation, a total of 1,124 patients were admitted for treatment. | 2020-04-28 |
| 32343423 | While this makes financial sense, from a medical perspective our population will be left defenseless in the absence of a viable treatment strategy for SARS-CoV-2. | 2020-04-28 |
| 32343428 | Third, when the second and third clusters could not find infectious sources, CECC’s press conference let the public know immediately the epidemic situation, so that people could raise their awareness and seek medical treatment or quarantine. | 2020-05-11 |
| 32343444 | Elderly patients with head and neck cancer are at increased risk of adverse outcomes during and after treatment of head and neck cancer. […] In many cases, prudent treatment plan modification may allow for overall best outcomes. […] Furthermore, recruitment of social services and, when appropriate, palliative care, may allow for optimal management of these patients. | 2020-05-29 |
| 32343454 | These changes raise a lot of questions regarding patient triage and treatment decisions in clinical situations when it is unclear if the workup and management can be postponed. | 2020-05-29 |
| 32343658 | These include virustatic agents that have already been approved for the treatment of other types of viral infection, as well as drugs that are currently used for entirely different purposes. […] Because the virus enters human cells by way of the membrane-associated angiotensin converting enzyme 2 (ACE2), keeping the virus from docking to this receptor is a conceivable treatment approach. […] There is not yet any recommendation for the therapeutic use of any particular agent beyond standard supportive treatment. | 2020-05-01 |
| 32343745 | Sex is an important biological variable that should be considered in the prevention and treatment of COVID-19. | 2020-05-13 |
| 32343968 | Anti-cytokine therapy such as tocilizumab, an IL-6 receptor antagonist, is a potential treatment for COVID-19; however, data regarding the efficacy of this anti-IL-6 therapy are currently lacking. […] Both patients progressed to sHLH despite treatment with tocilizumab, and one developed viral myocarditis, challenging the safety and clinical usefulness of tocilizumab in the treatment of COVID-19-induced CRS. | 2020-05-06 |
| 32344011 | Treatment in intensive care units (ICU) has become a major challenge; therefore, early recognition of severe forms is absolutely essential for timely triaging of patients. | 2020-05-29 |
| 32344056 | Eosinophil levels vary dramatically in a number of clinical settings, especially following eosinophil-targeted therapy, which is now available to selectively deplete these cells. | 2020-05-24 |
| 32344166 | Here we provide an update for clinicians on the recent developments in the virology, diagnostics, clinical presentation, viral shedding, and treatment options for COVID-19 based on current literature. […] We describe the virological characteristics of SARS-CoV-2 and the clinical course of COVID-19 with an emphasis on diagnostic challenges, duration of viral shedding, severity markers and current treatment options. […] For improved management of cases, there is a need to understand test probability of serology, qRT-PCR and radiological testing, and the efficacy of available treatment options that could be used in severe cases with a high risk of mortality. | 2020-05-22 |
| 32344202 | Vaccines that prevent SARS-CoV-2 infection and therapeutics that reduces the risk of severe Covid-19 are thus urgently needed. […] A rapid method to derive antiviral treatment for Covid-19 is the use of convalescent plasma derived hyperimmune globulin. | 2020-05-29 |
| 32344226 | Despite great efforts, there is no treatment of this disease. […] This article describes SARS-CoV-2, disease, prevention and management, treatment and social impact on society. […] However, Unani therapy may be useful along with allopathic treatment. | 2020-05-19 |
| 32344304 | Based on this observation, our proposed hypothesis is that 5-alpha-reductase inhibitors, that are commonly used for BPH treatment, may be one of the factors contributing to poorer prognosis in males. | 2020-05-18 |
| 32344310 | Alternate treatment strategies utilizing clinically available treatments such as hyperbaric oxygen therapy (HBOT), packed red blood cell (pRBC) transfusions, or erthropoiesis-stimulating agent (ESA) therapy were hypothesized to increase oxygenation of tissues by alternative means than standard respiratory and ventilator treatments. […] It was also revealed that alternative treatments currently being considered for COVID-19 such as chloroquine and hydroxychloroquine by increasing hemoglobin production and increasing hemoglobin availability for oxygen binding and acetazolamine (for the treatment of altitude sickness) by causing hyperventilation with associated increasing levels of oxygen and decreasing levels of carbon dioxide in the blood may significantly ameliorate COVID-19 respiratory symptoms. […] In conclusion, is recommend, given HBOT, pRBC, and ESA therapies are currently available and routinely utilized in the treatment of other conditions, that such therapies be tried among COVID-19 patients with serious respiratory conditions and that future controlled-clinical trials explore the potential usefulness of such treatments among COVID-19 patients with respiratory conditions. | 2020-05-18 |
| 32344313 | Despite the immense and ongoing global effort, no efficacious drugs to fight this plague have been identified and patients admitted to the intensive care units (ICU), for respiratory distress, are managed mostly by means of supportive care based on oxygen maintenance. […] TZD were widely used for type-2 diabetes in the first decade of this century and although concerns have been raised for possible side effects associated with long-term treatment, their use has been recently revaluated for their anti-inflammatory properties in numerous medical conditions. | 2020-05-18 |
| 32344320 | The dynamic levels of T lymphocyte in severe group were significantly lower from disease onset, but in the improved subgroup the value of T lymphocyte began to increase after about 15-day treatment and finally returned to the normal level. | 2020-05-27 |
| 32344438 | Questions were addressing the following issues: impact on nuclear medicine diagnostics and therapy, use of recommendations, personal protective equipment, and organizational adaptations. | 2020-04-28 |
| 32344439 | We also report on experiences with implementation of these approaches and treatment outcomes in the first 115 COVID patients. […] A multidisciplinary Task-force Coronavirus initiated measures concerning outpatient testing and counseling, reorganisation and separation of patient flow processes alongside with substantial escalation of inpatient capacities on regular wards and intensive care units. | 2020-05-22 |
| 32344441 | As such, clinical protocols and practice on labor and delivery units must adapt to optimize the safety of patients and health care workers and to better conserve health care resources. | 2020-04-28 |
| 32344444 | For both, plastic and hand surgeons it is crucial to act responsible, minimize the transmission of the virus and aid in reasonable and adequate allocation of resources for the treatment of affected patients during this pandemia. | 2020-04-28 |
| 32344449 | Hydroxychloroquine is an antimalarial drug being tested as a potential treatment for the novel coronavirus disease 2019 (COVID-19) pandemic caused by the severe acute respiratory syndrome coronavirus 2( (SARS-CoV-2. | 2020-04-28 |
| 32344456 | These recommendations focus on seven specific domains including: planning of resources and staffing; modifying the clinical environment; preparing equipment, supplies and drugs; selecting appropriate personal protective equipment; providing adequate oxygen therapy; assessing for and safely performing regional anaesthesia procedures; and monitoring during the conduct of anaesthesia and post-anaesthetic care. | 2020-05-14 |
| 32344469 | So far, no causative therapy nor protective vaccines are available. […] In this situation, useful prognostic parameters and targeted supportive treatment are urgently needed. | 2020-04-28 |
| 32344526 | Previous evidence suggests that RAS may represent an important target for the treatment of lung pathologies, especially for acute respiratory distress syndrome and chronic fibrotic disease. | 2020-05-01 |
| 32344708 | Since no specific therapy for these CoVs is available, any beneficial approach (including nutritional and dietary approach) is worth investigation. | 2020-05-29 |
| 32345226 | We retrospectively analyzed the clinical characteristics and treatment progress of 91 patients diagnosed with COVID-19 in Jingzhou Central Hospital. | 2020-04-30 |
| 32345443 | In view of the current pandemic by SARS-CoV-2 it deems essential to understand the key concepts about the infection: its epidemiological origin, presentation, clinical course, diagnosis and treatment (still experimental in many cases). | 2020-05-01 |
| 32345485 | This convalescent plasma therapy is of particular interest when a vaccine or specific therapy is not yet available for emerging viruses, such as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which causes COVID-19. […] It also includes recommendations for establishing a convalescent plasma program, enhancement considerations for convalescent plasma, and considerations around pathogen reduction treatment of convalescent plasma. […] The immediate use of convalescent plasma provides prompt availability of a promising treatment while specific vaccines and treatments are evaluated and brought to scale. […] Further development of improved convalescent plasma, vaccines and other therapeutics depends on quick generation of additional data on pathogenesis and immune response. | 2020-05-05 |
| 32345864 | Unprepared for this emergency, hospitals have quickly reformulated paths of assistance in an effort to guarantee treatment for infected patients. […] Orthopaedic departments have been focused on elderly traumatology, especially the treatment of femoral neck fractures in patients with coronavirus disease-2019 (COVID-19). […] The purpose of the present study was to evaluate the orthopaedic management strategy for femoral fragility fractures in COVID-19-positive patients with the hypothesis that operative treatment may contribute to the overall stability of the patient. […] Four patients who underwent surgical treatment died of respiratory failure on the first day after surgery (1 patient), the third day after surgery (2 patients), or the seventh day after surgery (1 patient). […] We noted a stabilization of respiratory parameters in 12 COVID-19-positive patients who underwent surgery treatment of proximal femoral fractures. | 2020-05-16 |
| 32346392 | This paper discusses the impact of coronavirus infection on cancer diagnosis and treatment in two leading cancer centres in Pakistan. […] There is an urgent need to evaluate the effect of delays in diagnosis and treatment on cancer stage and treatment, and to decide how to minimise these during likely future cycles of lockdown over the coming months and years. | 2020-05-01 |
| 32346394 | Cancer patients in conflict settings experience significant barriers in accessing chemotherapy and radiotherapy as well as palliative care and psychosocial support. | 2020-05-01 |
| 32346491 | No specific treatment has been reported. […] Herein, we examine the effects of Favipiravir (FPV) versus Lopinavir (LPV)/ritonavir (RTV) for the treatment of COVID-19. […] In this open-label nonrandomized control study, FPV showed significantly better treatment effects on COVID-19 in terms of disease progression and viral clearance; if causal, these results should be important information for establishing standard treatment guidelines to combat the SARS-CoV-2 infection. | 2020-05-01 |
| 32346492 | The second step is to prescribe a blood purification treatment for patients with COVID-19. | 2020-05-01 |
| 32346593 | This paper reviews the published literature, guidelines and consensus, and summarizes the clinical and imaging characteristics of COVID-19, in order to provide a reliable basis for early diagnosis and treatment. | 2020-05-11 |
| 32346656 | We implemented a novel remote RO SBRT coverage practice, requiring it to be reliable, of high audio and visual quality, timely, and the same level of specialty care as our current in-person treatment coverage practice. […] The time from CBCT to treatment was calculated before and after implementation to determine timeliness of remote coverage. […] Comfort levels with audio/visual communication as well as overall comfort in comparison to in-person RO coverage was evaluated using Likert scale surveys after treatment. […] Remote RO SBRT coverage was successfully implemented in 14/15 fractions with 3 observed process failures that were all corrected before treatment. […] Average times of pre-treatment coverage before and after implementation were 8.74 and 8.51min, respectively. | 2020-05-01 |
| 32346873 | The demographic characteristics, clinical data, treatment, and outcomes of SARS-CoV-2 infected patients without any symptoms were analyzed. | 2020-05-13 |
| 32347053 | Since SARS-CoV-2 and SARS-CoV are closely related, previous findings on SARS-CoV are highly relevant to a better understanding as well as diagnosis, treatment, prevention and control of SARS-CoV-2. […] In this review, we highlight recent progresses in the field; compare the biological characteristics of SARS-CoV and SARS-CoV-2; summarize the urgently-needed diagnostic, treatment, prevention and control options; and provide future perspectives for the outcome of the outbreak and research questions to be answered, including some of the difficulties in vaccine development. | 2020-05-01 |
| 32347201 | Predictors of lower odds of discharge were age > 65 years, antiviral treatment and for severe disease, lactate dehydrogenase > 300 mg/dL. | 2020-05-04 |
| 32347453 | The department of surgery played a leading role in establishing clinical protocols, guidelines, and policies in preparation for a surge of COVID-19 patients. | 2020-05-05 |
| 32347743 | Small studies have shown a potential benefit of chloroquine/hydroxychloroquine ± azithromycin for the treatment of COVID-19. […] The maximum QTc during treatment was significantly longer in the combination group vs the monotherapy group (470.4 ± 45.0 ms vs. […] Although use of these medications resulted in QT prolongation, clinicians seldomly needed to discontinue therapy. | 2020-04-29 |
| 32347745 | The current outbreak of SARS-CoV-2 has and continues to put huge pressure on intensive care units (ICUs) worldwide. | 2020-05-29 |
| 32347761 | For the dermatology community, this interruption to the healthcare system can lead to delays in the diagnosis and treatment of melanoma. | 2020-05-13 |
| 32347772 | Identified strategies included early recognition of the threat and rapid activation of national response protocols led by national leadership; rapid establishment of diagnostic capacity; scale-up of measures for preventing community transmission; and redesigning the triage and treatment systems, mobilizing the necessary resources for clinical care. | 2020-05-04 |
| 32348003 | Worldwide Coronavirus Disease 2019 (COVID-19) epidemic makes the management of acute myocardial infarction (AMI) more complicated, effective treatment without further dissemination is thus quite challenging. | 2020-05-01 |
| 32348025 | Furthermore, elective clinics and operations have been reduced in order to mobilize manpower to the acute specialties combatting the outbreak; appropriate differentiation between patients who require immediate care and those who can receive telephone consultation or whose treatment might viably be postponed is therefore crucial. | 2020-04-29 |
| 32348042 | Furthermore, treatment options against COVID-19 disease and adequate adjustment of immunosuppression in at risk patients remain a concern. | 2020-05-01 |
| 32348043 | Proper mitigation strategies in the clinic and use of less resource-heavy but equivalent treatment alternatives often allow optimal cancer care. | 2020-05-01 |
| 32348044 | Thrombocytopenia and procoagulant state are associated with severe courses of COVID-19, requiring an individualized therapy. | 2020-05-01 |
| 32348046 | Patients under immunosuppressive treatment are considered at high risk of severe outcome and are protected accordingly by the Swiss authorities. […] However, current, scarce scientific evidence suggests that patients under immunosuppressive therapy do not necessarily develop severe COVID-19 presentations. […] Therefore, the current guidelines recommend pursuing the treatment throughout the pandemic. | 2020-05-01 |
| 32348055 | Up to 5 % of COVID-19 infected patients develop severe acute hypoxemic respiratory failure requiring invasive mechanical ventilation as supportive treatment. […] Apart from early antiviral and anti-inflammatory treatment, the management of COVID-19 patients is mainly applying protective mechanical ventilation, to support the injured lungs. | 2020-05-01 |
| 32348056 | Alongside organizational challenges, clinical issues such as rapid respiratory distress, clinical suspicions with negative PCR and treatment uncertainties in the absence of sufficient evidence were overcome. | 2020-05-01 |
| 32348166 | With the capability of inducing elevated expression of ACE2, the cellular receptor for SARS-CoV-2, angiotensin II receptor blockers or angiotensin-converting enzyme inhibitors (ARBs/ACEIs) treatment may have a controversial role in both facilitating virus infection and reducing pathogenic inflammation. […] 126 COVID-19 patients with preexisting hypertension at Hubei Provincial Hospital of Traditional Chinese Medicine (HPHTCM) in Wuhan from January 5 to February 22, 2020 were retrospectively allocated to ARBs/ACEIs group (n=43) and non-ARBs/ACEIs group (n=83) according to their antihypertensive medication. 125 age- and sex-matched COVID-19 patients without hypertension were randomly selected as non-hypertension controls. […] In addition, the medication history of 1942 hypertension patients that were admitted to HPHTCM from November 1 to December 31, 2019 before COVID-19 outbreak were also reviewed for external comparison. | 2020-04-29 |
| 32348232 | O2 saturation was 87% (without O2 therapy). | 2020-04-29 |
| 32348233 | We report 3 patients with coronavirus disease who had a decline in respiratory status during their hospital course that responded well to intravenous steroids and interleukin-6 receptor antagonist therapy. | 2020-04-29 |
| 32348485 | Currently, the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) disease 2019 (COVID-19) has been reported in almost all countries globally, and no effective therapy has been documented for COVID-19 and the role of convalescent plasma therapy is unknown. […] In conclusion, convalescent plasma treatment can discontinue SARS-CoV-2 shedding but cannot reduce mortality in critically end-stage COVID-19 patients, and treatment should be initiated earlier. | 2020-05-06 |
| 32348554 | We wish to bring your attention to the PsoPROTECT (Psoriasis Patient Registry for Outcomes, Therapy and Epidemiology of Covid-19 infecTion) and SECURE-AD (Surveillance Epidemiology of Coronavirus Under Research Exclusion-Atopic Dermatitis) registries; two urgent global initiatives that address an unmet need for delineating the determinants of COVID-19 outcomes in the common cutaneous immune-mediated inflammatory diseases (IMIDs) psoriasis and atopic dermatitis. | 2020-04-29 |
| 32348585 | Imaging modalities such as chest radiography, thoracic and cardiovascular ultrasound, and computed tomography have roles in the diagnosis, prognosis, monitoring, and therapy of COVID-19. | 2020-04-29 |
| 32348588 | Here, we provide an overview of the known clinical features and treatment options for COVID-19. […] To date, there is no evidence of any effective treatment for COVID-19. […] The main therapies being used to treat the disease are antiviral drugs, chloroquine/hydroxychloroquine and respiratory therapy. […] Specifically designed randomized clinical trials are needed to determine the most appropriate evidence-based treatment modality. | 2020-05-13 |
| 32348598 | IBD medication adherence should be encouraged to prevent disease flare but where possible high-dose systemic corticosteroids should be avoided. […] The primary focus should remain on keeping bowel inflammation controlled and encouraging medication adherence. | 2020-05-26 |
| 32348692 | Use of inhaled corticosteroids (ICS) was associated with lower expression of ACE2 and TMPRSS2, but treatment with triamcinolone acetonide (TA) did not decrease expression of either gene. | 2020-05-22 |
| 32348711 | Palliative care is an important component of health care in pandemics, contributing to symptom control, psychological support, and supporting triage and complex decision making. […] Concerns included scarcity of personal protective equipment, a lack of hospice-specific guidance on COVID-19, anxiety about needing to care for children and other relatives, and poor integration of palliative care in the acute planning response. […] Governments must urgently recognise the essential contribution of hospice and palliative care to the COVID-19 pandemic and ensure these services are integrated into the health care system response. | 2020-05-15 |
| 32349032 | Radiographic technologies and tools, including Computed tomography (CT) and Chest X-ray (CXR), were applied for initial screening and follow-up, from which provides detail diagnosis with specific pathologic features for staging and treatment arrangement. | 2020-04-29 |
| 32349053 | With limited ability to contain the virus and relatively high transmissibility and case fatality rates, governmental institutions and pharmaceutical companies are racing to find therapeutics and vaccines that target this novel coronavirus. […] This is another missed opportunity to obtain pregnancy-specific safety and efficacy data, because therapeutics developed for men and nonpregnant women may not be generalizable to pregnant women. | 2020-05-26 |
| 32349115 | The proposed doses of chloroquine (CQ) and hydroxychloroquine (HCQ) for treatment of COVID-19 (1000 mg/day for 10 days, CQ; 800 mg first day then 400 mg/day for 5 days, HCQ) in many guidelines worldwide, are considerably higher than the maximum recommended daily safe doses of both agents (≤2.3 mg/kg/day, CQ; ≤5.0 mg/kg/day, HCQ) for development of retinal toxicity. | 2020-05-01 |
| 32349133 | The novel coronavirus 2019 (COVID-19) is clinically characterized by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which is responsible for a high number of patients needing mechanical ventilation or intensive care units treatment and for the elevated mortality risk. […] Furthermore, we discussed the biologic plausibility of the thrombotic risk in SARS-CoV-2 and the potential use of an antithrombotic treatment. | 2020-04-29 |
| 32349517 | So far, there is no specific anti-coronavirus therapy approved for the treatment of COVID-19. […] For a better popularization of TCM, governments have made several advances in regulations and policies for treatment and measures of novel coronavirus pneumonia (NCP). […] Therefore, on the basis of epidemiology and virology information, we reviewed relevant meta-analysis and clinical studies of anti-coronavirus therapeutics by TCM, in the aspect of mortality, symptom improvement, duration and dosage of corticosteroid, incidence of complications and the like. | 2020-04-30 |
| 32349902 | In these unprecedented times, OMFS surgeons are faced with dilemmas over the priority of treatment, safety of staff, safety of patients and the most appropriate use of available resources. | 2020-05-02 |
| 32349982 | Due to the frequent presence of interstitial lung disease and widespread use of immunosuppressive treatment, systemic sclerosis (SSc) patients may be considered at risk for a more severe disease course and higher mortality when they develop Severe Acute Respiratory Syndrome - Coronavirus - 2 (SARS-CoV-2) virus infection. | 2020-05-22 |
| 32350134 | The patients diagnosed as severe or critical COVID-19 in The First Affiliated Hospital of University of Science and Technology of China (Anhui Provincial Hospital) and Anhui Fuyang Second People’s Hospital were given tocilizumab in addition to routine therapy between 5 and 14 February 2020. […] Within 5 d after tocilizumab, 15 of the 20 patients (75.0%) had lowered their oxygen intake, and 1 patient needed no oxygen therapy. […] The percentage of lymphocytes in peripheral blood, which decreased in 85.0% of patients (17/20) before treatment (mean, 15.52 ± 8.89%), returned to normal in 52.6% of patients (10/19) on the fifth day after treatment. […] Preliminary data show that tocilizumab, which improved the clinical outcome immediately in severe and critical COVID-19 patients, is an effective treatment to reduce mortality. | 2020-05-22 |
| 32350543 | Due to their limited technical features, home respirators are not suitable for the treatment of severely affected patients but can be used for weaning after respiratory improvement, which means that intensive care respirators are available again more quickly. | 2020-05-11 |
| 32350584 | The collected data included patients’ demographics (age and gender), injury-related (injury type, fracture location, injury mechanism, places where fracture occurred), and treatment modality. | 2020-05-07 |
| 32350686 | According to the WHO, Centers for Disease Control and Prevention (CDC), and the US Food and Drug Administration (FDA), currently there are no medicines or vaccines that have been claimed to be useful in the prevention or treatment of COVID-19. […] According to the CDC and Chinese treatment guidelines for COVID-19, chloroquine, hydroxychloroquine, lopinavir/ritonavir, and one of the investigational agents (remdesivir) are recommended in critically ill older patients. […] The use of other potential drugs reported in different studies may be considered if treatment with first-line drugs is ineffective. […] There are currently no complete data available from large randomized clinical trials (RCTs) to provide clinical guidance on the use, dosing, or duration to validate the effective role, safety profile, and adverse effects of all of the trial drugs for prophylaxis or treatment of COVID-19. | 2020-05-29 |
| 32350773 | Some reported challenges in accessing HIV testing, prevention and treatment services. | 2020-05-09 |
| 32350794 | In this emergency situation, several expectations have been raised by the scientific community about the role that artificial intelligence can have in improving the diagnosis and treatment of coronavirus infection, and SIRM wishes to deliver clear statements to the radiological community, on the usefulness of artificial intelligence as a radiological decision support system in COVID-19 positive patients. | 2020-05-13 |
| 32350796 | The current global outbreak of COVID-19 represents a major challenge in terms of epidemiology, contagiousness, treatment, as well as clinical and radiological behavior of this disease. | 2020-05-13 |
| 32350818 | In the battle against the SARS-CoV‑2 pandemic, chloroquine has emerged as a new potential therapeutic option for the treatment of infected patients. […] A baseline electrocardiogram (ECG) and ECGs recorded during chloroquine treatment were retrospectively collected in patients suspected of having COVID-19. […] A total of 95 patients had a baseline ECG recording and at least one ECG recording during chloroquine therapy. […] Chloroquine treatment resulted in a mean QTc prolongation of 35 ms (95% CI 28-43 ms) using computerised interpretation and 34 ms (95% CI 25-43 ms) using manual interpretation. […] No torsade de pointes was observed during chloroquine treatment. […] After manual review, 22 patients (23%) had a QTc interval exceeding 500 ms during chloroquine treatment. […] None of these patients had a prolonged QTc interval prior to the initiation of chloroquine treatment. | 2020-05-25 |
| 32350857 | No major stakeholder seems to have considered how a pandemic deprives patients with a surgical condition of resources, with patients disproportionally affected owing to the nature of treatment (use of anaesthesia, operating rooms, protective equipment, physical invasion and need for perioperative care). | 2020-05-06 |
| 32350861 | COVID-19 may also be such a defining moment for clinical pharmacology in terms of its role in drug development and therapy. | 2020-04-30 |
| 32350928 | In addition, the known and potent immunomodulatory effects of these agents which support their use in the treatment of auto-immune conditions, and provided a component in the original rationale for their use in patients with COVID-19, may, in fact, undermine their utility in the context of the treatment of this respiratory viral infection. […] Given these facts and the growing uncertainty about these agents for the treatment of COVID-19, it is clear that at the very least thoughtful planning and data collection from randomized clinical trials are needed to understand what if any role these agents may have in this disease. […] In this article, we review the datasets that support or detract from the use of these agents for the treatment of COVID-19 and render a data informed opinion that they should only be used with caution and in the context of carefully thought out clinical trials, or on a case-by-case basis after rigorous consideration of the risks and benefits of this therapeutic approach. | 2020-05-06 |
| 32351121 | This raises the question whether the use of RAS inhibitors, the backbone of treatment of cardiovascular, neurovascular, and kidney diseases could increase the susceptibility for coronavirus infection or unfortunate outcomes of COVID-19. | 2020-05-25 |
| 32351196 | COVID-19 patients have characteristic reproducible laboratory findings and present a major challenge due to their illness severity and required treatment length. none. not relevant. | 2020-05-01 |
| 32351851 | Hydroxychloroquine therapy was started, and the patient responded favorably with improvement of symptoms. | 2020-05-05 |
| 32351873 | To systematically review and evaluate the pattern of COVID-19 and the treatment plans. […] The current research taking place to overcome this complex disease and the urgent need to develop improved therapeutics are also discussed. […] Herein, we present an epidemiological overview of the currently available information on the treatment claimed to have helped to bring the situation under control. | 2020-05-05 |
| 32352309 | OBJECTIVE. Because CT plays an important role in diagnosis, isolation, treatment, and effective evaluation of coronavirus disease (COVID-19), infection prevention and control management of CT examination rooms is important. CONCLUSION. We describe modifications to the CT examination process, strict disinfection of examination rooms, arrangement of waiting areas, and efforts to increase radiographers’ awareness of personal protection made at our institution during the COVID-19 outbreak. | 2020-04-30 |
| 32352401 | Presenting signs and symptoms, laboratory and imaging findings, treatment, and complications were recorded from electronic medical records (EMRs). | 2020-05-05 |
| 32352633 | Due to extended transportation delays to a cathlab, he received intravenous fibrinolytic therapy, which failed. […] Reperfusion was achieved with rescue coronary angioplasty, but the patient experienced two episodes of acute stent thrombosis at 2- and 36-hr following admission and despite optimal medical therapy. | 2020-04-30 |
| 32352637 | Increased vigilance and aggressive treatment of patients with obesity and COVID-19 are warranted. | 2020-04-30 |
| 32352944 | Interferon-alpha (5 million U twice daily by inhalation), lopinavir/ritonavir (400/100 mg twice daily orally), as well as chloroquine (500 mg twice daily orally for 10 days) and azithromycin (500 mg twice per day) cause a milder course of the disease and reduce the duration of treatment. | 2020-05-04 |
| 32353441 | Chest drain represent the first line treatment. | 2020-05-02 |
| 32353547 | Nigeria’s current national health systems cannot effectively respond to the growing needs of already infected patients requiring admission into intensive care units for acute respiratory diseases and severe acute respiratory syndrome (SARS COV-2) pneumonia. | 2020-05-29 |
| 32353597 | To our knowledge, this is the first reported investigation of a possible role of interleukin-17 target therapy in patients with lung cancer and concomitant severe acute respiratory syndrome-coronavirus-2 infection. | 2020-05-16 |
| 32353740 | We are suggesting here a strategy for the COVID-19 treatment that could be effective in curing the patients in the current scenario when no efficient medicine or Vaccine is currently available, and Clinicians solely depend upon the performing trials with drugs with known antiviral activities. | 2020-05-18 |
| 32353825 | Burns are an acute-care condition, and burn treatment needs to be initiated before COVID-19 infection status can be excluded. […] The key step to infection prevention is to identify risk points of infection exposure, strengthen the protection against those risk points, and formulate an appropriate diagnosis and treatment protocol. […] Following an in-depth study of the latest literature on COVID-19 diagnosis and treatment, we reviewed the protocols surrounding hospitalization of patients with extensive burns (area≥50 %) in our hospital from February 2009 to February 2019 and, in accordance with the epidemiological characteristics of COVID-19, developed an algorithm for protection during diagnosis and treatment of burns. […] Therefore, the aspects of medical protection and the diagnosis and treatment of burns appear to be particularly important during the prevention and control of the COVID-19. […] This algorithm was followed for 4 patients who received emergency treatment in February 2020 and were hospitalized. […] During the COVID-19 epidemic, the early stages of emergency treatment for patients with extensive burns requiring the establishment of venous access for rehydration, endotracheal intubation or tracheostomy, wound treatment, and surgery are the risk points for exposure to infection. […] The implementation of effective, appropriate-grade protection and formulation of practical treatment protocols can increase protection of healthcare worke and reduce the risk of COVID-19 infection exposure. | 2020-05-21 |
| 32353870 | Furthermore, treatment options for COVID-19 infection are currently limited. | 2020-05-08 |
| 32354030 | Taking into consideration the mortality rate of COVID-19, about 5-7%, and the percentage of positive patients admitted to intensive care units being 9-11%, it should be mandatory to consider and take all necessary measures to contain the COVID-19 infection. […] Moreover, given the recent evidence in different hospitals suggesting IL-6 and TNF-α inhibitor drugs as a possible therapy for COVID-19, we aimed to highlight that a dietary intervention could be useful to prevent the infection and/or to ameliorate the outcomes during therapy. | 2020-05-05 |
| 32354181 | More research on prevention and treatment is needed according to an analysis of term density. | 2020-05-06 |
| 32354369 | The patient received combination of interferonalfa-1b and ribavirin, lopinavir and ritonavir for antiviral treatment at different stages. […] Other medication was also given to him in combination for anti-inflammation, intestinal microbial regulation, phlegm elimination, liver protection and pulmonary fibrosis prevention purposes. […] We provided oxygen supply to him using BIPAP ventilator and high-flow humidification oxygen therapy instrument to facilitate respiration. […] This case report described an effective supportive medication scheme to treat SARS-COV-2 infected patient and emphasized the necessity of detection of the viral genome using BALF samples and its significance in the diagnosis and prognosis of the disease. | 2020-05-04 |
| 32354491 | The hospital network of our public health system has provided most of the resources for the treatment of patients affected by the infection. | 2020-05-03 |
| 32354634 | At admission, all had immunosuppression withdrawn and were started on methylprednisolone 16 mg/day, all but one was commenced on antiviral therapy and hydroxychloroquine with doses adjusted for kidney function. […] During a median follow-up of seven days, 87% experienced a radiological progression and among those 73% required escalation of oxygen therapy. | 2020-05-27 |
| 32354637 | Overall, two were managed on an out-patient basis, but the remaining five required hospital admission, four in intensive care units. […] Most patients had their immunosuppression reduced and were treated with supportive therapy. | 2020-05-28 |
| 32354734 | Palliative care is an important component of the medical response to pandemics and other health emergencies. […] The principles of palliative care do not change, but the practice of palliative care has to change as a result of factors such as greater demand and infection control measures. […] This article makes suggestions for palliative care provision during a pandemic (in developed countries), based on a limited review of the literature and personal experience of the ongoing pandemic (COVID-19 infection). | 2020-05-01 |
| 32354798 | We prospectively assessed the medical records, laboratory results, chest CT images and use of medication in a cohort of patients presenting to two designated covid-19 treatment centres in Sichuan, China. […] Outcomes of interest included death, admission to an intensive care unit (ICU), need for mechanical ventilation, treatment with vasoactive agents and classification of disease severity. […] Patients with acute myocardial injury were older, with a higher prevalence of pre-existing cardiovascular disease and more likely to require ICU admission (62.5% vs 24.7%, p=0.003), mechanical ventilation (43.5% vs 4.7%, p<0.001) and treatment with vasoactive agents (31.2% vs 0%, p<0.001). | 2020-05-01 |
| 32354800 | Specific cardiovascular considerations are also necessary in supportive treatment with anticoagulation, the continued use of renin-angiotensin-aldosterone system inhibitors, arrhythmia monitoring, immunosuppression or modulation, and mechanical circulatory support. | 2020-05-14 |
| 32354990 | Patients with IBD are at increased risk of infection, especially when they have active disease and are taking immunosuppressive therapy. […] Data regarding age, sex, IBD (type, treatments and clinical activity), other comorbidities (Charlson Comorbidity Index (CCI)), signs and symptoms of COVID-19 and therapies were compared with COVID-19 outcomes (pneumonia, hospitalisation, respiratory therapy and death). […] Thirty-six patients had COVID-19-related pneumonia (46%), 22 (28%) were hospitalised, 7 (9%) required non-mechanical ventilation, 9 (11%) required continuous positive airway pressure therapy, 2 (3%) had endotracheal intubation and 6 (8%) died. | 2020-05-28 |
| 32355107 | It is important to balance the need for access to healthcare services, including testing and treatment for sexually transmitted infections (STIs). | 2020-05-01 |
| 32355450 | These data were compared to the results of the tests conducted pre- and post-treatment. […] However, treatment group students who spent more time using mobile devices to learn the language did not display better performance compared to those who spent minimal time. | 2020-05-01 |
| 32355509 | Indeed, while the currently recommended treatment for uncomplicated acute appendicitis is surgical appendectomy, the non-surgical alternative of medical management by antibiotic therapy alone has been widely evaluated by high-quality studies in the literature. […] Insofar as the main limitation of exclusively medical treatment of uncomplicated acute appendicitis is the risk of recurrent appendicitis, this treatment option represents an alternative of choice to reduce the intra-hospital overload in this context of health crisis.The aim of this work is therefore to provide physicians and surgeons with a practical guide based on a review of the literature on the medical treatment of uncomplicated acute appendicitis in adults, to offer this alternative treatment to the right patients and under good conditions, especially when access to the operating room is limited or impossible. | 2020-05-01 |
| 32355564 | Dornase alfa should be considered for clinical trials in treatment of severe COVID-19. | 2020-05-21 |
| 32355607 | They are concerned about their risk of developing COVID-19 as many are immune suppressed from their disease and/or treatment, whether they should stop their advanced therapies, if they will have a worse outcome if/when infected due to their underlying medication condition(s) and if they will have drug availability, especially with press (without much data) coverage suggesting hydroxychloroquine may be used in COVID-19 infection causing diversion of medication supply. […] The long term effects of the pandemic in patients with rheumatic diseases will not be known until much later and likely include stressors flaring disease (fear, illness, job loss, social isolation), post-traumatic stress, flaring due to stopping medications, less physician visits with subsequent under-treatment, and increases in chronic concomitant fatigue, pain, fibromyalgia. | 2020-05-01 |
| 32355837 | Unfortunately, like the previous Coronavirus outbreaks, there is no definite antiviral therapy for the treatment of confirmed cases and hence preventing ourselves from contracting 2019-nCoV is the best way to prevent it from becoming pandemic. […] Herein, we aim to discuss the latest updates on the origin, genomic characteristics, diagnosis, treatment options and current efforts being made by international health organizations with regards to the 2019-nCoV outbreak. | 2020-05-05 |
| 32356252 | These two medications may precipitate ventricular dysrhythmias, necessitating cardiac and electrolyte monitoring, and in severe cases, treatment with epinephrine and high-doses of diazepam. […] Recombinant protein therapeutics may cause serum sickness or immune complex deposition. […] Here, we review the use, mechanism of action, and toxicity of proposed COVID-19 therapeutics. | 2020-05-08 |
| 32356301 | Past outbreaks of infectious diseases (Ebola and Zika virus) have shown that maladaptive behavior, related to increased psychological stress and anxiety, can interfere with the implementation of treatment strategies and actions and can contribute to a further spread. | 2020-05-29 |
| 32356626 | Using an observational database from 169 hospitals in Asia, Europe, and North America, we evaluated the relationship of cardiovascular disease and drug therapy with in-hospital death among hospitalized patients with Covid-19 who were admitted between December 20, 2019, and March 15, 2020, and were recorded in the Surgical Outcomes Collaborative registry as having either died in the hospital or survived to discharge as of March 28, 2020. | 2020-05-09 |
| 32356628 | We assessed the relation between previous treatment with ACE inhibitors, angiotensin-receptor blockers, beta-blockers, calcium-channel blockers, or thiazide diuretics and the likelihood of a positive or negative result on Covid-19 testing as well as the likelihood of severe illness (defined as intensive care, mechanical ventilation, or death) among patients who tested positive. […] Using Bayesian methods, we compared outcomes in patients who had been treated with these medications and in untreated patients, overall and in those with hypertension, after propensity-score matching for receipt of each medication class. […] There was no association between any single medication class and an increased likelihood of a positive test. | 2020-05-16 |
| 32356760 | Lung infection or pneumonia is the common complication of COVID-19, and imaging techniques, especially computed tomography (CT), have played an important role in diagnosis and treatment assessment of the disease. […] CT, positron emission tomography - CT (PET/CT), lung ultrasound, and magnetic resonance imaging (MRI) have been used for detection, treatment, and follow-up. | 2020-05-01 |
| 32356863 | Administration of hydroxychloroquine with or without azithromycin for the treatment of coronavirus disease 2019 (COVID-19)-associated pneumonia carries increased risk of corrected QT (QTc) prolongation and cardiac arrhythmias. […] In this cohort study, patients who received hydroxychloroquine for the treatment of pneumonia associated with COVID-19 were at high risk of QTc prolongation, and concurrent treatment with azithromycin was associated with greater changes in QTc. […] Clinicians should carefully weigh risks and benefits if considering hydroxychloroquine and azithromycin, with close monitoring of QTc and concomitant medication usage. | 2020-05-06 |
| 32356908 | Based on our analysis, delaying the onset of adaptive immune responses during the early phase of infections may be a potential treatment option for high-risk COVID-19 patients. | 2020-05-13 |
| 32356910 | This review was conducted to evaluate the effectiveness of CPT therapy in COVID-19 patients based on the publications reported till date. […] The main findings from available data are as follows: (a) Convalescent plasma may reduce mortality in critically ill patients, (b) Increase in neutralizing antibody titers and disappearance of SARS-CoV-2 RNA was observed in almost all the patients after CPT therapy, and (c) Beneficial effect on clinical symptoms after administration of convalescent plasma. […] Based on the limited scientific data, CPT therapy in COVID-19 patients appears safe, clinically effective, and reduces mortality. | 2020-05-13 |
| 32356955 | In the setting of anticipated resource scarcity in the future, we are forced to reconsider fibrinolytic therapy in our management algorithms. | 2020-05-15 |
| 32357072 | Epidemiologic, demographic, clinical, laboratory, treatment, and outcome data were analyzed. Results: The average age of the 28 patients was 68.6 ± 9.0 years. | 2020-05-01 |
| 32357074 | Although extracorporeal membrane oxygenation and other modalities of mechanical cardiopulmonary support are increasingly being utilized in the treatment of respiratory and circulatory failure refractory to conventional management, their role and efficacy as support modalities in the present pandemic are unclear. […] We review the rapidly changing epidemiology, pathophysiology, emerging therapy, and clinical outcomes of coronavirus disease 2019; and based on these data and previous experience with artificial cardiopulmonary support strategies, particularly in the setting of infectious diseases, provide consensus recommendations from American Society for Artificial Internal Organs. | 2020-05-05 |
| 32357281 | Being semi-emergent in nature, treatment for these patients is currently on hold or delayed in most centers across the country. | 2020-05-13 |
| 32357288 | These groups include infertility patients (eg, azoospermic and cryptozoospermic) undergoing medical or surgical treatment to improve sperm quantity and quality, as well as males of reproductive age affected by inflammatory and systemic auto-immune diseases who are about to start treatment with gonadotoxic drugs or who are under remission. | 2020-05-23 |
| 32357380 | A questionnaire was distributed to head and neck surgeons assessing opinions related to treatment and concerns for the safety of patients, self, family, and staff. […] Surgeons continued to recommend primary surgical treatment for oral cavity cancers. […] Respondents were more likely to consider non-surgical therapy for patients with early glottic cancers and HPV-mediated oropharynx cancer. | 2020-05-01 |
| 32357503 | Due to the scientific community’s efforts, there is an increasing body of published studies describing the virus’ biology, its transmission and diagnosis, its clinical features, its radiological findings, and the development of candidate therapeutics and vaccines. […] Only by working with a complete set of histological samples obtained through autopsy can one ascertain the exact cause(s) of death, optimize clinical management, and assist clinicians in pointing out a timely and effective treatment to reduce mortality. […] Death can teach us not only about the disease, it might also help with its prevention and, above all, treatment. | 2020-05-04 |
| 32357553 | Current treatment plans are still under investigation due to a lack of understanding of COVID-19. […] Hence, repurposing these drugs with a proper formulation is needed to improve the safety and efficacy for COVID-19 treatment. | 2020-05-05 |
| 32357575 | There is an urgent need to share expertise and clinical management skills with geriatricians as well as the need for early diagnosis to start treatment at the earliest convenience in the community, with the aim to avoid the collapse of intensive care units. | 2020-05-04 |
| 32357975 | Given this sense of randomness, and in the absence of a definitive treatment, medical professionals can feel helpless. | 2020-05-02 |
| 32357994 | Cancer patients are presumed to be at increased risk from COVID-19 infection fatality due to underlying malignancy, treatment-related immunosuppression, or increased comorbidities. | 2020-05-06 |
| 32358230 | Specific recommendations were made for surgical treatment of cancer, trauma and semi-urgent reconstructive procedures based on available data and literature. | 2020-05-15 |
| 32358232 | Although extracorporeal membrane oxygenation and other modalities of mechanical cardiopulmonary support are increasingly being utilized in the treatment of respiratory and circulatory failure refractory to conventional management, their role and efficacy as support modalities in the present pandemic are unclear. […] We review the rapidly changing epidemiology, pathophysiology, emerging therapy, and clinical outcomes of COVID-19; and based on these data and previous experience with artificial cardiopulmonary support strategies, particularly in the setting of infectious diseases, provide consensus recommendations from ASAIO. | 2020-05-30 |
| 32358234 | The threat of COVID-19 is particularly serious as there is no vaccine and no specific antiviral therapy. | 2020-05-14 |
| 32358406 | The patients continued to be given oxygen by mask and received antitussive, phlegm-dispelling treatment. | 2020-05-06 |
| 32358568 | Patients with malignant diseases are assumed to be at increased risk for a worse outcome of SARS-CoV-2 infection, and therefore, guidance regarding prevention and management of the infection as well as safe administration of cancer-therapy is required. | 2020-05-07 |
| 32358689 | Although chest X-ray (CXR) is considered not sensitive for the detection of pulmonary involvement in the early stage of the disease, we believe that, in the current emergency setting, CXR can be a useful diagnostic tool for monitoring the rapid progression of lung abnormalities in infected patients, particularly in intensive care units. | 2020-05-13 |
| 32358691 | Our results may help to identify the highest-risk patients and those who require specific treatment strategies. | 2020-05-13 |
| 32358791 | Whilst the authors reported an infection that occurred during therapy with an IL-23 inhibitor, we would like to briefly report one that occurred during therapy with an IL-17 inhibitor. | 2020-05-12 |
| 32358833 | In this review, we identify opportunities for drug discovery in the treatment of COVID-19 and in so doing, provide a rational roadmap whereby pharmacology and pharmacologists can mitigate against the global pandemic. | 2020-05-08 |
| 32358880 | There are three proposed major strategies to address care for patients with cancer in this SARS-CoV-2 pandemic with postponing treatment for those with stable cancer, increasing personal protection provisions for patients with cancer, and increasing monitoring if a patient becomes infected with SARS-CoV-2. | 2020-05-02 |
| 32358890 | A variety of repurposed drugs and investigational drugs such as remdesivir, chloroquine, hydroxychloroquine, ritonavir, lopinavir, interferon-beta, and other potential drugs have been studied for COVID19 treatment. | 2020-05-22 |
| 32358954 | On secondary analysis, 1450/2010 (72%) of patients reported received antimicrobial therapy. | 2020-05-06 |
| 32358956 | However, no significant difference in level of IgM and IgG antibody between positive and negative patients of nucleic acid test after treatment was found. | 2020-05-06 |
| 32359035 | No agent has yet been proven to be effective for the treatment of patients with severe COVID-19. […] Future controlled trials in patients with severe illness are urgently needed to confirm the definite benefit with IL-6 target therapy. | 2020-05-29 |
| 32359182 | we read with great interest the article entitled "Should SARS-CoV-2 influence immunosuppressive therapy for autoimmune blistering diseases? […] This is the first report of COronaVIrus DIsease 2019 (COVID-19) in a patient affected by autoimmune blistering disease (ABD) during immunosuppressive treatment (i.e. azathioprine). […] The authors conclude that it is crucial to learn of more cases of ABD patients under immunosuppressive treatment who have developed COVID-19, in order to better quantify the risk of infection under immunosuppressive therapy. | 2020-05-02 |
| 32359201 | The delayed and strong adaptive immune response (high affinity IgM and IgG antibodies) that follows, causes severe inflammation and triggers mediator cascades (complement, coagulation, and cytokine storm) leading to complications often requiring intensive therapy and being, in some patients, fatal. […] This “quantitative and time-sequence dependent” model has several implications for prevention, diagnosis, and therapy of COVID-19 at all ages. | 2020-05-02 |
| 32359203 | With supportive care as the current mainstay of treatment, the fatality rate of COVID-19 is 6.9%. […] There are currently several trials assessing the efficacy of different antivirals as treatment. […] In this study, the literature currently available on CQ and HCQ as treatment of COVID-19 was surveyed using EMBASE, PubMed, Cochrane Library, MedRxiv, and one clinical trial registry. | 2020-05-29 |
| 32359205 | Seven patients (58%) were on maintenance treatment with immunomodulators/biologics, of these 4 with combined therapy (33%). | 2020-05-02 |
| 32359771 | With the possibility that a considerable proportion of the world’s population soon could receive COVID-19 pharmacotherapies with torsadogenic potential for therapy or postexposure prophylaxis, this document serves to help health care professionals mitigate the risk of drug-induced ventricular arrhythmias while minimizing risk of COVID-19 exposure to personnel and conserving the limited supply of personal protective equipment. | 2020-05-06 |
| 32359788 | Specifically, it has been used in the treatment of many viral infections with varying degrees of clinical efficacy. | 2020-05-05 |
| 32359846 | At the same time, delaying treatment such as radiotherapy in cancer patients can be detrimental. | 2020-05-03 |
| 32359937 | The purpose of this study was to highlight the importance of timely brachytherapy treatment for patients with gynecologic, breast, and prostate malignancies, and provide a framework for brachytherapy clinical practice and management in response to the COVID-19 pandemic. […] There may be a significant negative impact on oncologic outcomes for patients with gynecologic malignancies who have a delay in the timely completion of therapy. […] Delay of prostate or breast cancer treatment may also impact oncologic outcomes. […] If a treatment delay is expected, endocrine therapy may be an appropriate temporizing measure before delivery of radiation therapy. […] Brachytherapy remains a critical treatment for patients and may shorten treatment time and exposure for some. […] Every effort should be made to ensure timely brachytherapy delivery for patients with gynecologic malignancies, and endocrine therapy may help temporize treatment delays for breast and prostate cancer patients. | 2020-05-06 |
| 32360053 | During this time, several patients requiring assessment and treatment of endodontic emergencies were directed to the School and Hospital of Stomatology at Wuhan University, Wuhan, China. […] Of the total patient visits during this period, 50.26% of visits were for endodontic treatment. […] Vital pulp therapy can advantageously reduce treatment time, resulting in a reduced risk of infection for vital pulp cases. | 2020-05-26 |
| 32360133 | It is unclear whether a more aggressive clinical course might develop in asymptomatic COVID-19 infected subjects during biological therapy and current evidence does not support treatment suspension. […] However, during pandemic, the start of treatment with immunosuppressive drugs and biologics should be postponed whenever possible and based on an individual risk assessment. […] When clinical conditions and the disease activity do not allow a treatment delay, before starting a biological therapy, screening of IBD patients for COVID-19 active infection by RT-PCR should be advisable, even in absence of clinical suspicion. | 2020-05-06 |
| 32360182 | Treatment with IFN-α or IFN-β at a concentration of 50 international units (IU) per milliliter reduces viral titers by 3.4 log or over 4 log, respectively, in Vero cells. […] The EC50 of IFN-α and IFN-β treatment is 1.35 IU/ml and 0.76 IU/ml, respectively, in Vero cells. […] Overall, our results demonstrate the potential efficacy of human Type I IFN in suppressing SARS-CoV-2 infection, a finding which could inform future treatment options for COVID-19. | 2020-05-29 |
| 32360231 | The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) pandemic is a global public health emergency, and new therapeutics are needed. […] It is hoped that knowledge of the potential drug target and mechanism of action of Arbidol will help in the development of new therapeutics for SARS-CoV-2. | 2020-05-17 |
| 32360238 | Palliative care providers play an important role in supporting their patients and family members in these difficult times. | 2020-05-17 |
| 32360420 | Guidelines for the diagnosis and treatment of SARS-CoV-2 infected pneumonia were first published January 30th, 2020; these guidelines recommended for the first time that cytokine monitoring should be applied in severely ill patients to reduce pneumonia related mortality. […] In view of the severe morbidity and mortality of COVID-19 pneumonia, we review the current understanding of treatment of human coronavirus infections from the perspective of a dysregulated cytokine and immune response. | 2020-05-13 |
| 32360432 | Antiretroviral therapy and prophylactic low molecular weight heparin treatment were initiated. […] In COVID-19 patients with prosthetic graft, an aggressive antithrombotic treatment could be considered to prevent such an event. | 2020-05-16 |
| 32360439 | Timely assessment and hyperacute treatment is the key to minimize mortality and morbidity of patients with acute stroke. | 2020-05-06 |
| 32360479 | To analyze the diagnosis and treatment of patients with chronic renal failure complicated with novel coronavirus pneumonia, and to evaluate the effect of blood purification technology on the treatment and prognosis of such patients. […] Two patients received continuous venovenous hemodiafiltration (CVVHDF) every other day for 4-6 h everytime, in addition to the standard treatment. | 2020-05-11 |
| 32360481 | According to the Shiyan experience, early diagnosis with multiple swaps of the Q-PCR test and timely treatment can reduce the death rate. | 2020-05-30 |
| 32360482 | Since nowadays no scientific evidence establishes a correlation between NSAIDS and worsening of COVID-19, patients should be advice against any NSAIDs self-medication when COVID-19 like symptoms are present. | 2020-05-30 |
| 32360500 | Collecting their data and forming a large sample for analysis is more conducive to the recognition, prevention and treatment of coronavirus disease 2019 in children. | 2020-05-07 |
| 32360578 | Patients with locally advanced NSCLC (LA-NSCLC) may require treatment in locations where resources are limited, and the prevalence of infection is high. […] Although guiding data is scarce, we present an expert thoracic oncology multidisciplinary (radiation oncology, medical oncology, surgical oncology) consensus of alternative strategies for the treatment of LA-NSCLC during a pandemic. […] The overarching goals of these approaches are the following: (1) reduce the number of visits to a health care facility, (2) reduce the risk of exposure to severe acute respiratory syndrome-coronavirus-2, (3) attenuate the immunocompromising effects of lung cancer therapies, and (4) provide effective oncologic therapy. […] Nonoperative options include chemotherapy, chemoimmunotherapy, and radiation therapy with sequential schedules that may or may not affect long-term outcomes in an era in which immunotherapy is available. […] Whenever radiation therapy is delivered without concurrent chemotherapy, hypofractionated schedules are appropriate. […] The risk of severe treatment-related morbidity and mortality is increased for patients undergoing treatment for LA-NSCLC during the COVID-19 pandemic. […] Adapting alternative treatment strategies as quickly as possible may save lives and should be implemented through communication with the multidisciplinary cancer team. | 2020-05-19 |
| 32360580 | At present, there is no specific antiviral treatment recommended for SARS-CoV-2 infection. […] The number of virions of SARS-CoV-2 was observed under transmission electron microscope after treatment with LS. […] These findings indicate that LS could inhibit SARS-CoV-2 virus infection via downregulating the expression of inflammatory cytokines induced virus and regulating the activity of NF-κB/MAPK signaling pathway in vitro, making its promising candidate treatment for controlling COVID-19 disease. | 2020-05-31 |
| 32360583 | This meta-analysis aimed at evaluating the efficacy and safety of current option of therapies for severe acute respiratory syndrome (SARS), Middle Eastern respiratory syndrome (MERS) besides COVID-19, in an attempt to identify promising therapy for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infected patients. […] We searched PubMed, EMBASE, Cochrane Library, China National Knowledge Infrastructure (CNKI), China Science and Technology Journal Database (VIP), and WANFANG DATA for randomized controlled trials (RCTs), prospective cohort, and retrospective cohort studies that evaluated therapies (hydroxychloroquine, lopinavir/ritonavir-based therapy, and ribavirin-based therapy, etc.) for SARS, MERS, and COVID-19. […] Compared with control treatment, anti-coronary virus interventions significantly reduced mortality (RR 0.65, 95% CI 0.44-0.96; I2 = 81.3%), remarkably ameliorate clinical improvement (RR 1.52, 95% CI 1.05-2.19) and radiographical improvement (RR 1.62, 95% CI 1.11-2.36, I2 = 11.0 %), without manifesting clear effect on virological eradication, incidence of ARDS, intubation, and AEs. | 2020-05-30 |
| 32360585 | Although many clinical trials are already underway and the majority of patients have received antiviral therapy based on medication experience with severe acute respiratory syndrome (SARS) and Middle East respiratory syndrome (MERS), and preliminary results from some clinical trials, there are no antiviral drugs proven to be effective currently. […] We summarize the current therapeutic medicines used in the clinic, hope to be able to provide some implications for clinical medication. | 2020-05-30 |
| 32360608 | Currently, no vaccine or approved medical treatment is available. | 2020-05-19 |
| 32360679 | The data from all patients who had tested positive for COVID-19 and had presented with ALI requiring urgent operative treatment were collected in a prospectively maintained database. […] Operative treatment was performed in 17 patients (85%). […] The use of prolonged systemic heparin might improve surgical treatment efficacy, limb salvage, and overall survival. | 2020-05-15 |
| 32360703 | COVID-19 requires the collaboration of nearly 200 countries to curb the spread of SARS-CoV-2 while gaining time to explore and improve treatment options especially for cardiovascular disease (CVD) and immunocompromised patients, who appear to be at high-risk to die from cardiopulmonary failure. […] Thus, RAAS inhibitors, which may increase the expression levels of ACE2, are commonly used for the treatment of hypertension and CVD. […] We aim to provide a list of potential treatment options and a better understanding of why CVD is a high risk factor for COVID-19 susceptibility and further discuss the acute as well as long-term cardiac consequences. | 2020-05-31 |
| 32361161 | In this paper, we will systematically review the pathogenic features, transmission routes, and infection mechanisms of SARS-CoV-2, as well as any adverse effects on the digestive system, urogenital system, central nervous system, and circulatory system, in order to provide a theoretical and clinical basis for the diagnosis, classification, treatment, and prognosis assessment of SARS-CoV-2 infection. | 2020-05-21 |
| 32361325 | At 213 confirmed cases under treatment and isolation, a range of interventions were enforced including intensive and expansive contact, mass testing, isolation, and sterilization. | 2020-05-27 |
| 32361327 | Clinical, laboratory, and treatment data were collected and analyzed from 111 hospitalized patients with laboratory-confirmed COVID-19 in Union Hospital. | 2020-05-27 |
| 32361388 | The results showed that people without public health emergency treatment experience showed worse performance in mental health, resilience and social support, and tended to suffer from psychological abnormality on interpersonal sensitivity and photic anxiety. | 2020-05-29 |
| 32361701 | in the reports presented about COVID-19, patients receiving kidney transplantation have not been specifically studied and based on national flowchart, this population is classified as highrisk group, thus it is necessary to be aware of the step-by-step treatment approach of these patients. […] Suspicious cases included patients with a history of dry cough, chills or sore throat accompanying by shortness of breath with or without fever, patients with upper/lower respiratory symptoms with radiological manifestations as single or double-sided multilobular infiltrations on CT scan or plain chest radiography, any one that has a history of close contact with a definite COVID-19 case within the last 14 days, any one with a history of presence in COVID-19 epidemic regions within the last 14 days and patient with pneumonia that despite of proper treatment has an inappropriate clinical response and clinical condition becomes more severe in an unusual way or unexpectedly. | 2020-05-06 |
| 32361703 | He was discharged healthy without development of new pulmonary symptoms despite immunosuppressive treatment. | 2020-05-06 |
| 32361715 | For his experiment Galen used the random allocation of treatment, today’s prospective randomised clinical trial, implemented in the evaluation of novel therapies, widely used internationally, particularly in cancer research! […] COVID-19, caused by the SARS-CoV-2 new corona virus, brought to the fore the randomised trial, as well as, the ethical dilemmas that surround the allocation of treatment at random, in the face of a devastating pandemic. […] Is it his/her right to request the active treatment that a fellow patient is receiving in the next bed? […] Although the Declaration of Helsinki allows the option of no treatment or even placebo, where no known treatment is available for a certain condition, such as COVID-19, it also emphasizes that “while the primary purpose of medical research is to generate new knowledge, this goal can never take precedence over the rights and interests of individual research subjects”. […] In this brief instance of medical history, the equipoise, the scientific imperative, all arguments and other justifications for providing treatment at random, were thrown out of the window in favour of the human factor! […] Because-it is presumed-the process of randomising subjects, protects the study from the selective inclusion of patients with favourable characteristics, thus inadvertently allowing or facilitating a falsely favourable result for the drug or treatment under investigation. […] Since the middle of the 20th century a generation of physicians have been trained to dismiss, or are incapable of evaluating the validity of a treatment beyond the established etiquette of the randomised study. | 2020-05-05 |
| 32361738 | Hypnotics may be an effective ancillary treatment for COVID-19. | 2020-05-06 |
| 32361744 | Remdesivir has received significant attention for its potential application in the treatment of COVID-19, caused by SARS-CoV-2. […] Remdesivir has already been tested for Ebola virus disease treatment and found to have activity against SARS and MERS coronaviruses. | 2020-05-06 |
| 32361747 | Broad-spectrum antimicrobial use is likely to be widespread among hospitalized patients, both as directed and empiric therapy. […] Prospective studies on COVID-19 superinfections are needed, data from which can inform rational antimicrobial treatment and stewardship strategies, and models for market reform and sustainable drug development. | 2020-05-06 |
| 32361927 | Only life-threatening pathologies like periprosthetic fractures and acute septic TJA are currently undergoing surgical treatment. | 2020-05-29 |
| 32362005 | Rapid and effective diagnoses are vital for the isolation of infected people and starting treatment immediately to stop the spread of COVID-19 virus. | 2020-05-21 |
| 32362061 | Therefore, the current data seem to suggest that treatment with dupilumab should not be stopped during COVID-19 pandemic. | 2020-05-21 |
| 32362134 | Aesthetic providers will face new and unique challenges as government stay-at-home orders and related commercial limitations are eased, and the U.S. economy reopens and healthcare systems transition from providing only urgent and other essential treatment to resuming routine care and elective procedures and services. […] In a number of areas, this Guidance Supplement exceeds traditional aesthetic office safety precautions, recognizing reduced tolerance in an elective treatment environment for any risk associated with COVID-19’s highly variable presentation and unpredictable course. | 2020-05-04 |
| 32362193 | Whether asymptomatic patients are contagious or not and whether they need medication are the arguments among clinical experts.Areas covered: This paper reports a special asymptomatic couple with COVID-19, of which the male patient is an intercity bus driver but has not induced confirmed infection of his 188 passengers. […] Their clinical characteristics and medication were summarized and analyzed.Expert opinion: The two asymptomatic patients far away from Wuhan did not seem to be highly contagious. […] They improved obviously, after treatment with the quadruple therapy, but the effective drug is still unknown. | 2020-05-14 |
| 32362235 | Our research group has established that noscapine is a chemotherapeutic agent for the treatment of drug resistant cancers; however, noscapine was also being used as anti-malarial, anti-stroke and cough-suppressant. | 2020-05-14 |
| 32362245 | Currently, several clinical trials are underway to identify specific drugs for the treatment of this novel virus. | 2020-05-20 |
| 32362296 | The diagnosis of COVID-19 was based on positive COVID-19 nucleic acid testing according to the unified triage standards of the Guidelines for the Diagnosis and Treatment of Novel Coronavirus Pneumonia (Trial version 4),4 issued by the National Health Commission of the People’s Republic of China. | 2020-05-20 |
| 32362299 | Treatment with psychotropic medication may sometimes be jeopardised because of the COVID-19 pandemic. | 2020-05-28 |
| 32362344 | Clinical, laboratory, and radiologic results, as well as treatment outcome data, were obtained. […] A total of 70 patients underwent CT imaging repeatedly after treatment. […] High body mass index (OR, 1.285; p = 0.017) and tobacco smoking (OR, 16.13; p = 0.032) were independent risk factors associated with disease exacerbation after treatment. | 2020-05-06 |
| 32362368 | Indeed, while the currently recommended treatment for uncomplicated acute appendicitis is surgical appendectomy, the non-surgical alternative of medical management by antibiotic therapy alone has been widely evaluated by high-quality studies in the literature. […] Insofar as the main limitation of exclusively medical treatment of uncomplicated acute appendicitis is the risk of recurrent appendicitis, this treatment option represents an alternative of choice to reduce the intra-hospital overload in this context of health crisis. […] The aim of this work is therefore to provide physicians and surgeons with a practical guide based on a review of the literature on the medical treatment of uncomplicated acute appendicitis in adults, to offer this alternative treatment to the right patients and under good conditions, especially when access to the operating room is limited or impossible. | 2020-05-06 |
| 32362392 | All cases were mild and successfully recovered after proper treatment. | 2020-05-07 |
| 32362440 | No specific and effective anti-viral treatment has been approved for COVID-19 so far. […] Systemic corticosteroid has been sometimes administered to severe infectious diseases combined with the specific treatment. […] However, as lack of the specific anti-SARS-CoV-2 drug, systemic steroid treatment has not been recommended for COVID-19. […] Rationale of the treatment is to mitigate the local inflammation with inhaled steroid that stays in the lung and to inhibit proliferation of the virus by antiviral activity. | 2020-05-20 |
| 32362644 | Hospitalized adult patients with laboratory-confirmed SARS-CoV-2 infection with any one of the following criteria will be eligible to receive lopinavir/ritonavir for 14 days after obtaining written informed consent: (i) respiratory distress with respiratory rate ≥22/min or SpO2of <94 per cent; (ii) lung parenchymal infiltrates on chest X-ray; (iii) hypotension defined as systolic blood pressure <90 mmHg or need for vasopressor/inotropic medication; (iv) new-onset organ dysfunction; and (v) high-risk groups - age >60 yr, diabetes mellitus, renal failure, chronic lung disease and immunocompromised persons. […] Treatment outcomes amongst initial cases would be useful in providing guidance about the clinical management of patients with COVID-19. | 2020-05-06 |
| 32362735 | Until now there is no effective treatment or drug present to control its life-threatening effects in the humans. | 2020-05-07 |
| 32362969 | The main aim of this systematic review is to provide a comprehensive clinical summary of all the available data from high-quality research articles relevant to the epidemiology, demographics, trends in hospitalization and outcomes, clinical signs and symptoms, diagnostic methods and treatment methods of COVID-19, thus increasing awareness in health care providers. | 2020-05-07 |
| 32363045 | Based on the current epidemic situation, this study reviewed publications on this virus and coronavirus disease 2019 (COVID-19), analyzed common features of respiratory viral pneumonias, and presented the currently reported clinical characteristics of COVID-19 in transplant recipients to improve strategies regarding the diagnosis and treatment of COVID-19 in this special population. | 2020-05-07 |
| 32363133 | This generated a remarkable race to find solutions for the prevention, treatment and management of this disease which is involving a large amount of people. | 2020-05-07 |
| 32363136 | Currently, there is no specific viral protein-targeted therapeutics. | 2020-05-14 |
| 32363157 | The United States Food and Drug Administration has not approved any drug or vaccine for the treatment of COVID-19; however, reports have emerged from different parts of the world about the potential therapeutic benefits of existing drugs. | 2020-05-07 |
| 32363212 | We call for additional randomized controlled trial evidence prior to the widespread incorporation of hydroxychloroquine and chloroquine into national and international treatment guidelines. | 2020-05-04 |
| 32363219 | Re-purposing the available protease inhibitor drugs for immediate use in treatment in SARS-CoV-2 infections could improve the currently available clinical management. | 2020-05-07 |
| 32363221 | A cluster of patients were admitted with unusual pneumonia not responding to treatment in various hospitals. | 2020-05-07 |
| 32363222 | The clinical features and treatment outcomes of twelve paediatric patients confirmed as COVID-19 were analyzed. […] All patients received antiviral and symptomatic treatment and the symptom relieved in 3-4 days after admitted to hospital. | 2020-05-07 |
| 32363334 | We reviewed existing literature surrounding the role of VA-ECMO in the treatment of coronavirus-related cardiovascular collapse. […] The decision to initiate this therapy should take into consideration availability of resources, perceived benefit as well as risks of transmitting disease. | 2020-05-07 |
| 32363880 | Here, we discuss the potential of these therapies for the treatment of coronavirus disease 2019. | 2020-05-29 |
| 32363963 | This is a report of a case with mucous membrane pemphigoid (MMP) with severe eye involvement and concurrent COVID-19 treated successfully using simultaneous high dose intravenous immunoglobulin (IVIg) and anti-viral treatment as hydroxychloroquine, lopinavir/ritonavir, and ribavirin. | 2020-05-15 |
| 32364011 | Given the absence of a current vaccine or specific antiviral treatment, it is urgent to search for FDA-approved drugs that can potentially inhibit essential viral enzymes. […] Although, captopril is shown to be a potential ligand of 3CLpro, it is not recommended anti-COVID-19 therapy, due to the fact that it can induce the expression of the viral cellular receptor such as, angiotensin-converting enzyme ACE-2, and thus, making the patient potentially more susceptible to infection. | 2020-05-20 |
| 32364028 | While healthcare systems need to cope with the need to treat a large number of people with different degrees of respiratory failure, actions to preserve aliquots of the healthcare system to guarantee treatment to patients are mandatory. […] Of these, 47 were hospitalized, 53 needed a differential diagnosis to continue with their cancer treatment, and 201 were about to undergo surgery. | 2020-05-04 |
| 32364041 | So far, however, there no effective treatment has been found to stop this new generation of coronavirus but discovering of the crystal structure of SARS-CoV-2 main protease (SARS-CoV-2 Mpro) may facilitate searching for new therapies for SARS-COV-2. […] The current study provides a powerful in silico results, means for rapid screening of drugs as anti-protease medications and recommend that the above-mentioned drugs can be used in the treatment of SARS-CoV-2 in combined or sole therapy.Communicated by Ramaswamy H. | 2020-05-20 |
| 32364048 | The paper considers the recently published British Medical Association Guidance on ethical issues arising in relation to rationing of treatment during the COVID-19 Pandemic. […] It considers whether it is lawful to create policies for the rationing and withdrawal of treatment, and goes on to consider how such policies might apply in practice. […] Legal analysis is undertaken of certain aspects of the Guidance which appear to misunderstand the law in respect of withdrawing treatment. | 2020-05-18 |
| 32364119 | Research is currently focused on understanding the acute infection and developing effective treatment strategies. | 2020-05-10 |
| 32364527 | Thus, taking control of changes in immune factors could be critical in the treatment of COVID-19. | 2020-05-26 |
| 32364677 | A liver and kidney transplant patient with SARS-CoV-2 pneumonia without respiratory failure was treated in a clinical multimodal strategy consisting of symptomatic support therapy, immunosuppression reduction, use of anti-coronavirus drugs and heparin leading to a progressive improvement of patient symptoms till discharge. | 2020-05-26 |
| 32365215 | Hydroxychloroquine and chloroquine are currently being evaluated as treatment against COVID-19. | 2020-05-07 |
| 32365415 | For patients with severe aortic stenosis, efforts to bring treatment to symptomatic patients amid this pandemic might lead to favored use of catheter based management using minimalist techniques that do not require these elements. | 2020-05-04 |
| 32365466 | Given the lack of registered clinical therapies or vaccines, many physicians and scientists are investigating previously used clinical drugs for COVID-19 treatment. […] Besides, we summarize the recently investigated drugs that constitute an option for COVID-19 treatment. | 2020-05-05 |
| 32365556 | Thus, an immunomodulatory approach targeting the over-production of cytokines could be proposed for viral aggressive pulmonary disease treatment. | 2020-05-07 |
| 32365891 | As this was a current study, there are still not many sources in the literature, and scientific strategies are moving towards therapy and diagnosis, rather than knowing the characteristics of the virus. | 2020-05-08 |
| 32366025 | Overall, our results suggest that the higher divergence observed for the latter three genes could represent a significant barrier in the development of antiviral therapeutics against SARS-CoV-2. | 2020-05-07 |
| 32366034 | Realizing the severity of outcomes associated with this disease and its high rate of transmission, dentists were instructed by regulatory authorities, such as the American Dental Association, to stop providing treatment to dental patients except those who have emergency complaints. […] Dentists at all times should competently follow cross-infection control protocols, but particularly during this critical time, they should do their best to decide on the emergency cases that are indicated for dental treatment. […] This overview will address several issues concerned with the COVID-19 pandemic that directly relate to dental practice in terms of prevention, treatment, and orofacial clinical manifestations. | 2020-05-08 |
| 32366173 | Epistaxis is a common complaint in the general population, and its treatment is a common procedure in emergency departments. | 2020-05-05 |
| 32366178 | With no vaccine or definitive treatment, public health authorities have recommended a strategy of “social distancing,” reducing individual interaction, canceling elective procedures, and limiting nonessential services. […] Health care providers must determine what procedures are considered “elective,” balancing risk of treatment delays with that of coronavirus exposure to patient, family, and providers. | 2020-05-05 |
| 32366290 | The number of severe cases has increased dramatically worldwide, while specific treatment options are scarce. […] In this commentary, we summarize the clinical trials of MSCs treatments on ALI/ARDS and raise MSCs as a hopefully alternative therapy for severe or critical COVID-19. | 2020-05-07 |
| 32366740 | Ibuprofen is an over-the-counter medication that is used widely for the treatment of pain and fever during COVID-19 pandemic. | 2020-05-23 |
| 32366746 | This article summarized the understanding of the etiology, pathogenesis, epidemiology, clinical characteristics, diagnosis, treatment, rehabilitation, and prevention and control measures of COVID-19 based on the available data and anti-epidemic experience in China. | 2020-05-05 |
| 32366817 | Vaccines and targeted therapeutics for treatment of this disease are currently lacking. […] This cross-neutralizing antibody targets a communal epitope on these viruses and may offer potential for prevention and treatment of COVID-19. | 2020-05-06 |
| 32367170 | All patients referred to 4 intensive care units (ICUs) from two centers of a French tertiary hospital for acute respiratory distress syndrome (ARDS) due to COVID-19 between March 3rd and 31st 2020 were included. […] Sixty-four clinically relevant thrombotic complications were diagnosed in 150 patients, mainly pulmonary embolisms (16.7%). 28/29 patients (96.6%) receiving continuous renal replacement therapy experienced circuit clotting. | 2020-05-13 |
| 32367205 | High-dose steroid treatment allowed neurological and respiratory recovery. […] Prompt invasive treatment should be adopted to avoid hypoxic neurotoxicity and prevent CNS injuries. | 2020-05-08 |
| 32367683 | Apart from being an infectious disease, it may affect human behavior and healthcare resource allocation which potentially cause treatment delay in MI. | 2020-05-05 |
| 32367812 | He developed respiratory failure and was transferred to the intensive care unit where he received further treatment, including tocilizumab (IL-6 receptor inhibitor). | 2020-05-06 |
| 32367847 | In rapid systematic review, we found studies showing some improvement in prevention and treatment of upper respiratory tract infections. | 2020-05-05 |
| 32367852 | Currently, no effective therapy or vaccine is available to manage this illness. | 2020-05-05 |
| 32367888 | CONCLUSIONS The dynamic changes of CT images of lungs of COVID-19 patients, combined with the clinical manifestations and laboratory indicators of patients, can help guide clinical diagnosis and treatment. | 2020-05-06 |
| 32368252 | In this scenario, neoadjuvant endocrine treatment could be an appropriate alternative treatment for hormone receptor positive breast cancer (luminal-like tumours) in order to minimise hospital admissions and to delay elective surgeries. | 2020-05-08 |
| 32368429 | Radiation therapy is another essential clinical service that cannot afford to suffer prolonged delays without compromising patient outcomes. […] Early action and guidance are therefore critical to minimize transmission events and ensure safe and timely delivery of radiation therapy. […] The purpose of this report is to describe the institutional patient experience and quantify the impact of treatment delays and interruptions over the first month of the COVID-19 outbreak. | 2020-05-08 |
| 32368550 | On day 9 after conservative treatment, her condition was alleviated. | 2020-05-08 |
| 32368570 | The present study review is on the general continent, virology, pathogenesis, global epidemiology, clinical presentation, diagnosis, treatment and control of COVID-19 with the reference to India. | 2020-05-07 |
| 32368712 | To address this racial disparity, we must apply a health equity lens and disaggregate data explicitly for African Americans, as well as other populations at risk for biased treatment in the health-care system. | 2020-05-07 |
| 32368875 | There is no publication involving protection measures for diagnostic and therapeutic procedures in nuclear medicine (NM) (appointment, patient acceptance, imaging and treatment procedures, disinfection etc). […] In cancer cases requiring urgent treatment, radionuclide treatment (RNT) should be planned according to the COVID-19 test result. | 2020-05-14 |
| 32368884 | The management of mild cases of confirmed infection is another point of controversy, as drugs which may be repurposed for COVID-19 treatment have significant, potentially irreversible toxic effects and their use in mild cases of a viral illness which is typically self-limited may be harmful. | 2020-05-07 |
| 32368894 | At 85 °C, 30% RH, we were able to perform 50 cycles of heat treatment without significant changes in the filtration efficiency. […] At low humidity or dry conditions, temperatures up to 100 °C were not found to alter the filtration efficiency significantly within 20 cycles of treatment. […] Ultraviolet (UV) irradiation was a secondary choice, which was able to withstand 10 cycles of treatment and showed small degradation by 20 cycles. | 2020-05-29 |
| 32369030 | Third, guidelines for rehabilitation (physiotherapy, occupational therapy, speech-language pathology) following COVID-19 have been proposed with respect to recovery of the respiratory system as well as recovery of mobility and function. […] A thorough assessment and an individualized, progressive treatment plan which focuses on function, disability, and return to participation in society will help each patient to maximize their function and quality of life. | 2020-05-21 |
| 32369097 | There have been recommendations to discontinue these medications, which are essential in the treatment of several chronic disease conditions, while, in the absence of clinical evidence, professional societies have advocated their continued use. […] However, further study in larger numbers of hospitalized patients receiving ACEI and ARB therapy is needed to determine the association with clinical measures of COVID-19 severity. | 2020-05-14 |
| 32369191 | However, it is not possible to ascertain which adverse events were directly related to tocilizumab therapy. | 2020-05-11 |
| 32369192 | The reasons for the consults are mostly familiar-surrogate decision-making, informed refusal of treatment, goals of care, defining futility. | 2020-05-05 |
| 32369205 | A total of 344 patients with mild COVID-19 were included in the final analysis, 45 of whom progressed and needed high-flow oxygen therapy or mechanical ventilation after admission. | 2020-05-18 |
| 32369208 | On the basis of antiviral drugs, antibiotics treatment, appropriate dosage of corticosteroid and gamma globulin therapy significantly improve patients’ outcomes. […] Early identification and timely medical treatment are important to reduce the severity of patients with COVID-19. | 2020-05-05 |
| 32369222 | The management of COVID-19 patients includes epidemiological risk and patient isolation; treatment entails general supportive care, respiratory support, symptomatic treatment, nutritional support, psychological intervention, etc. | 2020-05-23 |
| 32369429 | Increased awareness of this fact may encourage earlier diagnosis and treatment, as well as heighten vigilance for viral transmission. | 2020-05-05 |
| 32369431 | With our skill set, otolaryngologists are poised to support various aspects of hospital wards, intensive care units, emergency departments, and beyond. | 2020-05-05 |
| 32369433 | Respiratory therapists, intensivists, nursing leadership and the palliative care interdisciplinary team participated in focus groups. […] Key informant interviews were conducted with emergency management, respiratory therapy and emergency medicine. | 2020-05-05 |
| 32369601 | In this consensus statement, an international group of experts present mitigation strategies and treatment guidance for patients suffering from high grade gliomas (HGG) during the coronavirus disease 2019 (COVID-19) pandemic. 16 international experts in the treatment of HGG contributed to this consensus-based practice recommendation including neuro-oncologists, neurosurgeons, radiation -oncologists and a medical physicist. […] Generally, treatment of neuro-oncological patients cannot be significantly delayed and initiating therapy should not be outweighed by COVID-19. […] We present detailed interdisciplinary treatment strategies for molecular subgroups in two pandemic scenarios, a scale-up phase and a crisis phase. […] This practice recommendation presents a pragmatic framework and consensus-based mitigation strategies for the treatment of HGG patients during the SARS-CoV-2 pandemic. | 2020-05-29 |
| 32369624 | Liver transplantation (LT) centers should adapt to the pandemic by considering leniency to some LT candidates with ALD who cannot access appropriate alcohol treatment due to the current situation. | 2020-05-09 |
| 32370561 | Without the ability to efficiently screen patients, hospitals are overwhelmed, potentially delaying treatment for other emergencies. […] Early screening and triage is achievable from the outset of a pandemic with point-of-care host immune response testing which will improve response time to clinical and public health actions.Key messagesDelayed testing deployment has led to uncertainty surrounding overall disease burden and community spread, severely hampering public health containment and healthcare system preparation efforts.A multi-tiered testing strategy incorporating rapid, host immune point-of-care tests can be used now and for future pandemic planning by effectively identifying patients at risk of disease thereby facilitating quarantine earlier in the progression of the outbreak during the weeks and months it can take for pathogen specific confirmatory tests to be developed, validated and manufactured in sufficient quantities.The ability to triage patients at the point of care and support the guidance of medical and therapeutic decisions, for viral isolation or confirmatory testing or for appropriate treatment of COVID-19 and/or bacterial infections, is a critical component to our national pandemic response and there is an urgent need to implement the proposed strategy to combat the current outbreak. | 2020-05-21 |
| 32370758 | An accurate evaluation of RdRps from different viruses may guide the development of new drugs or the repositioning of already approved antiviral drugs as treatment of SARS-CoV-2. | 2020-05-11 |
| 32370766 | To date, there is no specific anti-COVID-19 treatment. | 2020-05-07 |
| 32370981 | We conducted a national online survey to assess the evolution of electroconvulsive therapy (ECT) in the different centres practicing this treatment. 65 responses from all over France were analysed. | 2020-05-08 |
| 32370982 | There are also major issues when referring patients with acute mental disorders to intensive care units. | 2020-05-08 |
| 32370984 | In France, this large-scale health crisis urgently triggered the restructuring and reorganization of health service delivery to support emergency services, medical intensive care units and continuing care units. | 2020-05-08 |
| 32370986 | Since the ACE2 (angiotensin-converting enzyme 2) enzyme is the receptor that allows SARS COV2 entry into cells, the fear was that pre-existing treatment with ACEi or ARB might increase the risk of developing severe or fatal severe acute respiratory syndrome in case of COVID-19 infection. | 2020-05-08 |
| 32371027 | Consensus on Science and Treatment recommendations aim to balance the benefits of early resuscitation with the potential for harm to care providers during the COVID-19 pandemic. | 2020-05-20 |
| 32371416 | Following treatment with oseltamivir and short-term methylprednisolone combined with symptomatic management, all three patients recovered within 3 weeks, as evidenced by the disappearance of their symptoms, clearance of pulmonary infiltrates and consecutive negative molecular diagnostic test findings. […] Our observations suggest the importance of preventing family transmission and the efficacy of current integrated treatment for mild/moderate pneumonia in COVID-19 cases. | 2020-05-07 |
| 32371479 | Early reports suggest that tocilizumab, an IL6 receptor-blocking antibody used to manage toxicities associated with chimeric antigen receptor T-cell therapy, may help control cytokine storms in people infected with COVID-19. | 2020-05-06 |
| 32371555 | ECMO is a resource-intensive therapy that can be considered in highly selected patients. […] Expert centers should employ an evidence-based ARDS treatment algorithm and a multidisciplinary approach to recommending ECMO upon failure of conventional therapy. | 2020-05-06 |
| 32371557 | The mechanism of SARS-CoV-2 and associated myocardial injury, whether SARS-CoV-2 patients with myocardial injury are a distinct population, and possible treatment options for myocardial injury associated with SARS-CoV-2 are unknown. | 2020-05-06 |
| 32371558 | Data on HCQ for treatment of coronavirus disease 2019 (COVID-19) are rapidly evolving. […] To date there is no evidence from randomized controlled trials that any single therapy improves outcomes in patients infected with COVID-19. […] There are also no clinical trial data supporting prophylactic HCQ therapy in COVID-19. […] Hydroxychloroquine (HCQ) use in patients with COVID-19 is being investigated examining prophylaxis, postexposure prophylaxis, and treatment regimens. | 2020-05-06 |
| 32371560 | Positive airway pressure (PAP) therapy is an open system that can generate contact, droplet, and airborne COVID-19 thereby increasing the risk of transmission of COVID-19 like other procedures such as tracheal intubation, noninvasive ventilation, and cardiopulmonary resuscitation. […] Medically prudent recommendations have been established for home use of PAP therapy in asymptomatic patients and patients with suspected or confirmed COVID-19. | 2020-05-06 |
| 32371562 | Based on expert opinion, strategies for outpatient management include use of elexacaftor-tezacaftor-ivacaftor to reduce pulmonary exacerbations, telemedicine, adherence to prescribed regimens, prompt and aggressive treatment of CF exacerbations, and communication about COVID-19 with patients with CF. | 2020-05-06 |
| 32371563 | During this pandemic, it is recommended that patients with asthma continue taking all controller inhalers and other asthma medication as prescribed to prevent exacerbations and limit outpatient clinic and emergency room exposure. | 2020-05-06 |
| 32371624 | The complications from COVID-19 can be reduced by (1) delivering interdisciplinary rehabilitation that is initiated early and continued throughout the acute hospital stay, (2) providing patient/family education for self-care after discharge from inpatient rehabilitation at either acute or subacute settings, and (3) continuing rehabilitation care in the outpatient setting, and at home through ongoing therapy either in-person or via telehealth. | 2020-05-06 |
| 32372573 | As the global prevalence of diabetes continues to increase, patients with endocrine diseases such as diabetes mellitus and those who are on long-term corticosteroid therapy due to adrenal insufficiency or hypopituitarism are at risk for a poor prognosis of COVID-19. | 2020-05-06 |
| 32372695 | More than 2,000,000 individuals worldwide have had coronavirus 2019 disease infection (COVID-19), yet there is no effective medical therapy. […] Multiple off-label and investigational drugs, such as chloroquine and hydroxychloroquine, have gained broad interest due to positive pre-clinical data and are currently used for treatment of COVID-19. […] Many antibiotics commonly used for the treatment of patients with COVID-19, for instance azithromycin, can also prolong QT interval. […] This review summarizes evidenced-based data regarding potential cardiac adverse effects due to off-label and investigational drugs including chloroquine and hydroxychloroquine, antiviral therapy, monoclonal antibodies, as well as common antibiotics used for the treatment of COVID-19. | 2020-05-29 |
| 32372821 | The covid-19 pandemic has encouraged more people to make advance treatment decisions relating to CPR and ventilation, reports Clare Wilson. | 2020-05-06 |
| 32373183 | Chloroquine and closely related structural analogs, employed initially for the treatment of malaria, are now gaining worldwide attention due to the rapidly spreading pandemic caused by severe acute respiratory syndrome-coronavirus-2, named coronavirus disease (COVID) of 2019 (COVID-19). […] This review aims to present the available in vitro and clinical data for the role of chloroquine/hydroxychloroquine in COVID-19 and attempts to put them into perspective, especially in relation to the different risks/benefits particular to each patient who may require treatment. | 2020-05-20 |
| 32373461 | The current Opinion Paper is one of the first attempts, to my understanding, to summarize and integrate environmental and human health aspects related to the monitoring, fate and treatment solutions for COVID-19. | 2020-05-08 |
| 32373721 | Low dose radiotherapy (0,5 Gy), is an evidence-based anti-inflammatory treatment, that could modify the immune landscape in the lung affected of SARS-CoV-2 pneumonia, through macrophages polarization to alternatively activated Macrophages (M2 phenotype). […] LDRT is a cost-effective non-toxic treatment already available in most general hospitals. | 2020-05-08 |
| 32373992 | SARS-Cov-2 has a strong infection, and the mortality rate of severe patients after infection is high, but there is no effective treatment. […] In this short report, combined with the progress of preclinical and clinical research, we comment the efficacy of MSCs in the treatment of COVID-19. | 2020-05-08 |
| 32373993 | The aim of this study was to indirectly investigate the efficacy of chloroquine and hydroxychloroquine for the treatment of COVID-19 by determining the prevalence of COVID-19 in malaria pandemic and non-pandemic nations. […] We sought evidence to support or refute the hypothesis that these drugs could show efficacy in the treatment of COVID-19. […] The studies on "COVID-19 and its allied treatment were found from World Health Organization (WHO), ISI-Web of Science, PubMed, EMBASE, Scopus, Google Scholar, and clinical trial registries. […] The search was based on keywords: antiviral drugs, chloroquine, hydroxychloroquine, COVID-19, COVID-19 treatment modalities, and coronavirus. […] The findings support the hypothesis that these drugs have efficacy in the treatment of COVID-19. | 2020-05-08 |
| 32373997 | There are currently no effective antiviral drugs treatment for the affected children. […] No sufficient results have been reached by the use of interferon (IFN), lopinavir/ritonavir, orbidol, and oseltamivir in the treatment of the coronaviruses infection. | 2020-05-08 |
| 32373998 | Meanwhile, we analyzed the epidemiologic and clinical characteristics of COVID-19, in order to provide recommendations for present clinical treatments and inspirations for potential therapy options. | 2020-05-08 |
| 32373999 | Current researches on potentially effective treatment alternatives are discussed. | 2020-05-08 |
| 32374000 | Due to the high mortality rate and the lack of optimum therapeutics, it is crucial to understand the biological characteristics of the virus and its possible pathogenesis to respond to the SARS-CoV-2. […] Rapid diagnostics and effective therapeutics are also important interventions for the management of infection control. […] However, the rapid evolution of SARS-CoV-2 exerted tremendous challenges on its diagnostics and therapeutics. […] In this review, we focus on our current understanding of epidemiology, pathogenesis, diagnostics and therapeutics of coronavirus disease 2019 (COVID-19). | 2020-05-08 |
| 32374001 | We highlighted the role of HLA haplotype in virus infection as HLA typing will provide susceptibility information for personalized prevention, diagnosis, and treatment in future studies. | 2020-05-08 |
| 32374007 | Chinese Clinical Guidance for COVID-19 Pneumonia Diagnosis and Treatment (7th edition) by National Health Commission is recommended to follow as it provides detailed diagnostic procedures using currently available tools. | 2020-05-08 |
| 32374026 | Nor is there sufficient evidence base to conclude that alternative approaches to treatment are incorrect. | 2020-05-06 |
| 32374074 | The main protease (Mpro , also called 3-chymotrypsin-like protease) of SARS-CoV-2 is a potential target for treatment of COVID-19. | 2020-05-29 |
| 32374264 | These examples also reveal the unlimited opportunity to future-proof our health care systems by proactively mining, synthesizing, cataloging, and evaluating the off-label treatment opportunities of thousands of safe, well-established, and affordable generic drugs. | 2020-05-26 |
| 32374440 | Members of the AGS Ethics Committee collaborated with interprofessional experts in ethics, law, nursing, and medicine (including geriatrics, palliative care, emergency medicine, and pulmonology/critical care) to conduct a structured literature review and examine relevant reports. | 2020-05-14 |
| 32374474 | Outbreaks of infections with viruses like Sars-CoV-2, Ebola virus and Zika virus lead to major global health and economic problems because of limited treatment options. | 2020-05-06 |
| 32374538 | Diagnosis is based on PCR from a nasopharyngeal swab and emergency treatment rely on oxygen therapy. | 2020-05-08 |
| 32374541 | Antidiabetic therapy may need adjustments following usual sick day rules. […] Insulin therapy should be considered to treat any persistent hyperglycemia in patients hospitalized for an acute infection. | 2020-05-08 |
| 32374806 | The authors propose psychological interventions for prevention and treatment in order to mitigate the pandemic’s psychological impacts. | 2020-05-11 |
| 32374823 | Prevotella may have role in COVID-2019 outbreak and should be given importance for understanding disease mechanisms and improving treatment outcomes. | 2020-05-06 |
| 32375011 | This article critically appraises the opportunities and challenges exergames present for the prevention and treatment of anxiety disorders in a home-based environment during the COVID-19 quarantine period. | 2020-05-06 |
| 32375025 | Because of the vital role that these S proteins play, they represent a vulnerable target for the development of therapeutics. […] These data provide a molecular basis for the neutralization of pathogenic betacoronaviruses by VHHs and suggest that these molecules may serve as useful therapeutics during coronavirus outbreaks. | 2020-05-29 |
| 32375085 | Diverse clinical manifestations and laboratory abnormalities occur in patients with cardiovascular injury in COVID-19, characterizing the development of this complication, as well as providing clues to diagnosis and treatment. | 2020-05-08 |
| 32375144 | The COVID-19 pandemic has stressed patients and healthcare givers alike and challenged our practice of antenatal care, including fetal diagnosis and therapy. | 2020-05-06 |
| 32375200 | Here we present a series of five cases of severe pneumomediastinum requiring decompression therapy over a 7-day period in the current COVID-19 outbreak. | 2020-05-06 |
| 32375268 | In this context, novel approaches in both gene therapy and vaccine development are essential. | 2020-05-07 |
| 32375446 | In order to achieve the overall victory over 2019 novel coronavirus disease epidemic, especially to prevent the disease recurrence from rebounding during the resumption of labor, the government has not loosened any control of personnel mobility, which has obviously affected the normal examination and treatment of lung cancer patients under the influence of this epidemic. […] It is necessary to provide more appropriate individualized treatment recommendations for patients with lung cancer based on the epidemic situation of the patient’s location and in combination with the patient’s own condition. […] Through active prevention of infection, timely conversion of treatment strategies, online and offline joint control, and positive psychological counseling, we do our best to help patients with lung cancer to survive this difficult period. | 2020-05-11 |
| 32375487 | This paper describes, besides general measures in times of a pandemic, also the necessary changes in the invasive diagnosis and treatment of patients presenting with different entities of acute coronary syndromes including structural adaptations (networks, spokes and hub centres) and therapeutic adjustments. | 2020-05-29 |
| 32375488 | There has been increasing sharing experience regarding the patient’s clinical features over the last weeks which has underlined the need for general guidance on treatment strategies. | 2020-05-29 |
| 32375564 | The only resource is people themselves using self-help, self-medication and self-care. | 2020-05-07 |
| 32375574 | The reemergence of coronavirus prompts the need for the development of effective therapeutics to prevent the cellular entry and replication of coronavirus. | 2020-05-20 |
| 32375845 | Thus, fully understanding the characteristics of COVID-19-related ARDS is conducive to early identification and precise treatment. | 2020-05-11 |
| 32375887 | The impact of COVID-19 across health services, including treatment services for people who use drugs, is emerging but likely to have a high impact. […] Treatment services for people who use drugs provide essential treatment services including opiate agonist treatment and needle syringe programmes alongside other important treatment programmes across all substance types including withdrawal and counselling services. […] Ensuring ongoing supply of opiate treatment during these periods will require significant changes to how treatment is provided. […] Ensuring people who use drugs have access to drug treatment as well as access to screening and testing for SARS-CoV2 where this is indicated is important. | 2020-05-11 |
| 32376004 | If there is no curative treatment for infection to SARS-CoV-2, the interactions of the various molecules currently tested with several classes of psychotropic drugs (antidepressants, antipsychotics) are important to consider because of the risk of changes in cardiac conduction. | 2020-05-09 |
| 32376099 | Given their equal efficacy but fewer adverse events, ARBs could potentially be a more favorable treatment option in patients with COVID-19 at higher risk for severe forms of disease. | 2020-05-09 |
| 32376170 | The rapid surge of patients presenting over a small period for emergent clinical care, admission to the hospital, and intensive care units with many requiring mechanically assisted ventilators for respiratory support demonstrated the potential to overwhelm health care workers, hospitals, and health care systems. | 2020-05-09 |
| 32376263 | Family members of patients admitted to the acute palliative care unit and hospice were screened for a period of two weeks. | 2020-05-22 |
| 32376346 | For this reason, the Government of Lombardy decided to centralize the treatment of ACS patients in a limited number of centers, including our university cardiology institute, which in the past 4 weeks became a cardiovascular emergency referral center in a regional hub-and-spoke system. | 2020-05-09 |
| 32376394 | Furthermore, we must keep in mind that currently, no specific antiviral treatment is available for SARS-CoV-2. […] While moderate-severe forms need in-hospital surveillance plus antivirals and/or hydroxychloroquine; in severe and life-threating subsets a high intensity anti-inflammatory and immunomodulatory therapy could be a therapeutic option. | 2020-05-29 |
| 32376397 | Severe patients are hospitalized and the treatment is done, though they have not been established yet. […] Currently, however, no treatment is provided for those who are isolated at home or shelter until they get severe symptoms, which will increase the harms to the patients. | 2020-05-30 |
| 32376402 | As no specific therapeutics are yet available to control disease evolution, more in-depth understanding of the pathogenic mechanisms induced by SARS-CoV-2 will help to characterize new targets for the management of COVID-19. | 2020-05-29 |
| 32376531 | It is therefore essential to provide timely treatment opinions and prevention methods for common skin problems. | 2020-05-08 |
| 32376532 | The control measures to contain the epidemic also produced influences on the transport and treatment process of patients with acute myocardial infarction (AMI), and adjustments in the management of the patients need to be made at this particular time. […] AMI is characterized by an acute onset with potentially fatal consequence, a short optimal treatment window, and frequent complications including respiratory infections and respiratory and circulatory failure, for which active on-site treatment is essential. […] To standardize the management and facilitate the diagnosis and treatment, we formulated the guidelines for the procedures and strategies for the diagnosis and treatment of AMI, which highlight 5 Key Principles, namely Nearby treatment, Safety protection, Priority of thrombolysis, Transport to designated hospitals, and Remote consultation. […] For AMI patients, different treatment strategies are selected based on the screening results of SARS-CoV-2, the time window of STEMI onset, and the vital signs of the patients. […] In the transport and treatment of AMI patients, the physicians should strictly observe the indications for patient transport with appropriate protective measurements of the medical staff. | 2020-05-08 |
| 32376546 | The selection of appropriate detection techniques and methods for accurate and rapid identification of pathogens therefore plays a key role in improving the diagnosis and treatment of the patients and containing the outbreak. | 2020-05-08 |
| 32376573 | According to the Fifth Edition of the Diagnosis and Treatment Guidelines by the National Health Commission, the patients were divided into common type, severe type and critical type. […] MSCT volume scanning not only allows early diagnosis of COVID-19 but also provides evidence for evaluating the severity of COVID-19 to assist in the clinical treatment of the patients. | 2020-05-11 |
| 32376583 | We review the experience with the diagnosis and treatment of secondary cerebral infarction in an elderly patient with coronavirus disease 2019 (COVID-19). […] Early anti-infection therapy, immune regulation and appropriate anticoagulation intervention may help improve the prognosis of the patients. | 2020-05-11 |
| 32376587 | RCTs provides the gold standard for evaluating the effectiveness of a given treatment for the patients from the outbreaks. | 2020-05-11 |
| 32376588 | Under the instructions by the E’zhou Medical Team Front Command, the staff made quick responses to the surging number of patients with COVID-19 and rapidly formulated treatment plans based on the local conditions. | 2020-05-11 |
| 32376592 | Twelve patients were still on endotracheal mechanical ventilation in the intensive care unit, and one of them received ECMO treatment due to poor oxygenation. […] For patients with severe and critical COVID-19 and indications of tracheal intubation, we recommend early intubation with invasive respiratory support to improve the treatment efficacy and reduce the mortality. | 2020-05-11 |
| 32376627 | The coronavirus disease COVID-19, caused by emerging SARS-CoV-2, has posed serious threats to global public health, economic and social stabilities, calling for the prompt development of therapeutics and prophylactics. | 2020-05-07 |
| 32376714 | The fundamental role of the spike protein in infectivity suggests that it is an important target for vaccine development, blocking therapy with antibodies and diagnostic antigen-based tests. | 2020-05-07 |
| 32377176 | Pancreatic cancer is a very aggressive disease and survival remains dismal even with treatment. […] Although we have general strategies available from experience in Italy, we need more treatment specific strategies to help mitigate risks of complications and toxicities from chemotherapy in order to protect our patients from COVID-19 as much as possible. | 2020-05-13 |
| 32377375 | Identification of novel BCR signaling may lead to the development of vaccines and antibodies for the treatment of COVID-19. | 2020-05-09 |
| 32377468 | Her RT-PCR test was negative after five days of treatment, suggesting that children can clear the virus faster than adults. […] These findings serve as a practical reference for the clinical diagnosis and medical treatment of children with COVID-19. | 2020-05-09 |
| 32377486 | Although the chief focus is on minimizing transmission through prevention, combating infection, and saving lives by ramping up the development of treatment and vaccines, very little attention is on the critical issue of physician burnout, resident burnout, and the psychological well-being of HCW. | 2020-05-09 |
| 32377559 | An expert US committee developed the US NIH guidelines for COVID-19 treatment, which was just released and will be regularly updated. | 2020-05-09 |
| 32377596 | This study reviews the impact of COVID-19 on a hospital system in New York on aspects of medicine, nursing, radiation therapy, and administration.Materials/Methods: A retrospective review was conducted of the department of radiation oncology in a single health system in New York from 3/1/20 to 4/1/20. […] Collaboration was obtained from physicians, nursing, radiation therapy, and administration to recall their policies and impact on specific duties. […] Numbers were obtained for patients on treatment, treatments breaks, and COVID-19 infections amongst staff and patients. […] Radiation Oncology made aggressive efforts to reduce patients on treatment to protect patients and staff as well reallocate staff and space for more acute clinical needs. | 2020-05-07 |
| 32377638 | Moreover, additional clinical data are needed in order to determine whether a supportive therapy can help mitigate the development of severe, potentially fatal complications, and further studies are needed to identify the pathophysiology and the mechanism underlying this novel coronavirus-associated infectious disease. | 2020-05-09 |
| 32377677 | We searched PubMed and bioRxiv/medRxiv to identify English language papers describing the testing, treatment and prognosis of COVID-19. […] Screening of over 1100 peer-reviewed and pre-print papers yielded n = 22 on COVID-19 testing, n = 15 on treatment and n = 13 on prognosis. | 2020-05-29 |
| 32378314 | Despite reduction in immunosuppression and treatment with tocilizumab, intravenous immunoglobulin, hydroxychloroquine, lopinavir/ritonavir, and broad-spectrum antibiotics, she ultimately died from multiorgan failure. | 2020-05-22 |
| 32378459 | Application of nanobiotechnology could represent a new avenue for the treatment or disinfection of viruses. | 2020-05-07 |
| 32378471 | Current clinical treatment at hand is inadequate to suppress viral replication and inflammation, and reverse organ failure. […] Intensive research efforts have focused on increasing our understanding of viral biology of SARS-CoV-2, improving antiviral therapy and vaccination strategies. […] We will discuss the benefits and caveats of these animal models and present critical findings that might guide the fundamental studies and urgent treatment of SARS-CoV-2-caused diseases. | 2020-05-15 |
| 32378647 | Interleukin 6 (IL-6) inhibitor (tocilizumab) had been suggested for the treatment of acute respiratory distress syndrome (ARDS) patients based on the concept of “cytokine storm” in COVID-19. […] The efficacy of IL-6 monoclonal antibody-directed therapy remains to be fully evaluated. | 2020-05-08 |
| 32378729 | More importantly, a compre-hensive understanding of pathological mechanisms of COVID-19 will increase the efficacy of therapy and decrease mortality. | 2020-05-29 |
| 32378737 | Combination therapy should be evaluated in vitro. […] Re-purposing drugs for use in COVID-19 treatment is an ideal strategy but is only feasible when product safety has been established and experiments of re-purposed drugs are conducted at clinically relevant concentrations. | 2020-05-07 |
| 32378801 | In this article, we compared SARS-CoV-2 with SARS-CoV and influenza virus, discussed current researching progress of COVID-19, including clinical characteristics, pathological changes, treatment measures, and so on. | 2020-05-22 |
| 32378805 | There have already been examples of self-medication and overdose. | 2020-05-13 |
| 32378844 | A total of nine patients (21 %) had a critical course of illness with treatment in the Intensive Care Department and/or death during their stay in hospital. | 2020-05-12 |
| 32378854 | Together, these findings may inform future research, diagnosis, prevention and treatment of COVID-19. | 2020-05-12 |
| 32379056 | We prefer a simple and convenient treatment regimen, which may also be postponed appropriately. […] In total, adequate doctor-patient communication is also recommended throughout the treatment. | 2020-05-26 |
| 32379057 | During this period, our infection and orthopedic treatment unit in the center of the epidemic area effectively treated 82 elderly patients with hip fracture, and no cross-infection occurred. […] Therefore, our experience in prevention and treatment is worth recommending to frontline anti-epidemic personnel. | 2020-05-26 |
| 32379114 | Analyses of early prognosis were based on clinical outcomes and trends in laboratory results during treatment. […] Surgical treatment should be carried out cautiously or nonoperative care should be chosen for patients with fracture in COVID-19-affected areas, especially older individuals with intertrochanteric fractures. | 2020-05-20 |
| 32379199 | However, our understanding of the clinical characteristics and treatment of critically ill pediatric patients and their ability of transmitting the coronavirus that causes COVID-19 still remains inadequate because only a handful pediatric cases of COVID-19 have been reported. […] Epidemiology, clinical characteristics, treatment, laboratory data and follow-up information and the treatment of critically ill infant were recorded. | 2020-05-08 |
| 32379346 | In the present comment the treatment of COVID19 patients with ACE2 activators, such as diminazene aceturate (DIZE), which are currently used as antiparasitic drugs, is proposed. | 2020-05-18 |
| 32379639 | This review aimed to summarize and analyze the pattern identification (PI), herbal formulae, and composition of herbs provided by recent guidelines for the treatment of pediatric COVID-19. […] This review serves as a reference for the use of traditional medicine in the treatment of pediatric COVID-19. | 2020-05-11 |
| 32379667 | Patients with Coronavirus Disease 2019(COVID-19) will experience high levels of anxiety and low sleep quality due to isolation treatment. […] During this period, the control group received only routine care and treatment. | 2020-05-11 |
| 32379692 | No effective treatment for this disease was verified, so the morbidity and mortality rate were supposed higher than flu. | 2020-05-11 |
| 32380026 | Instead of redeploying pediatric providers to work with internist-led teams throughout a medical center, pediatric physicians and nurses organized and staffed a 40-bed adult COVID-19 treatment unit within a children’s hospital. | 2020-05-23 |
| 32380051 | The outbreak of emerging infectious pneumonia caused by 2019 Novel Coronavirus (2019-nCoV) has posed an enormous threat to public health, and traditional Chinese medicine (TCM) have made vast contribution to the prevention, treatment and rehabilitation of coronavirus disease 19 (COVID-19) among Chinese population. […] Given this, based on the Guideline on Diagnosis and Treatment of Coronavirus Disease 2019 in China, the present review summarized the basic information, clinical evidence and published literatures of recommended CPMs against COVID-19. […] The details were thoroughly introduced involving compositions, therapeutic effects, clinical indications, medication history of CPMs and the profiles of corresponding research. | 2020-05-30 |
| 32380200 | The antiviral peptides can prevent SARS-CoV-2 membrane fusion and can potentially be used for the prevention and treatment of infections. | 2020-05-09 |
| 32380210 | For the N gene and ORF1ab gene, the CT values of 4 inactivated and Non-inactivated treatment were correlated (P＜0.001). […] The results of the four treatment methods and specimens without inactivated treatment have shown good consistency. […] The treatment of nasopharyngeal swab specimens using mentioned four inactivated methods had no significant effect on the subsequent detection of the new COVID-19 nucleic acid test. | 2020-05-31 |
| 32380315 | A comparison was conducted between subjects tested positive for SARS-CoV-2 and those found negative in terms of rate of administration of hydroxychloroquine/colchicine therapy. | 2020-05-23 |
| 32380453 | There has so far been no evidence from randomized controlled trials to prescribe any particular anti-nCoV treatment or vaccine, and COVID-19 management has been widely supportive. | 2020-05-20 |
| 32380474 | • The main complication of desmopressin treatment in DI is dilutional hyponatraemia. | 2020-05-08 |
| 32380475 | • Clinical evaluation should guide those needing investigation • Strict adherence to COVID-19 protection measures is necessary • Alternative ways of consultations (telephone, video) should be used • Early discussion with regional/national experts about investigation and management of potential and existing patients is strongly encouraged • Patients with moderate and severe clinical features need urgent investigation and management • Patients with active Cushing’s syndrome, especially when severe, are immunocompromised and social shielding is recommended • In patients with mild features or in whom a diagnosis is less likely, clinical re-evaluation should be repeated at three and six months or deferred until the prevalence of SARS-CoV-2 has significantly decreased • Diagnostic pathways may need to be very different from usual recommendations in order to reduce investigations • When extensive differential diagnostic testing is not feasible, it should be deferred, and medical treatment should be initiated • Transsphenoidal pituitary surgery may be avoided during high SARS-CoV-2 viral prevalence • Medical management rather than surgery will be the used for most patients since the short- to mid-term prognosis depends in most cases on hypercortisolism rather than its cause; it should be initiated promptly to minimize the risk of infection in these immunosuppressed patients. | 2020-05-08 |
| 32380511 | The mouse model with SARS-CoV-2 infection will be valuable for evaluating antiviral therapeutics and vaccines as well as understanding the pathogenesis of COVID-19. | 2020-05-07 |
| 32380582 | The actual sanitary crisis led to a massive mobilization of the sanitary system toward intensive care units and management of coronavirus disease 2019 (COVID-19) patients. | 2020-05-08 |
| 32380891 | We explore here the impact of this unique crisis on victims of elder mistreatment and people at risk of victimization. […] The COVID-19 outbreak has also had a profound impact on the organizations from many sectors that typically respond to protect and serve victims of elder mistreatment. | 2020-05-23 |
| 32380903 | These findings will be of significant use in guiding the development of serologic tests, formulating convalescent plasma therapy strategies, and assessing the longevity of protective immunity for SARS-related coronaviruses in general as well as vaccine efficacy. | 2020-05-11 |
| 32380908 | This prospective nonrandomized open-label cohort study addresses the safety and efficacy of exosomes (ExoFlo™) derived from allogeneic bone marrow mesenchymal stem cells as treatment for severe COVID-19. […] Patients received a single 15 mL intravenous dose of ExoFlo and were evaluated for both safety and efficacy from days 1 to 14 post-treatment. […] In total, 17 of 24 (71%) patients recovered, 3 of 24 (13%) patients remained critically ill though stable, and 4 of 24 (16%) patients expired for reasons unrelated to the treatment. […] Overall, after one treatment, patients’ clinical status and oxygenation improved with an average pressure of arterial oxygen to fraction of inspired oxygen ratio (PaO2/FiO2) increase of 192% (P < 0.001). | 2020-05-23 |
| 32381073 | The chest computed tomography (CT) revealed scattered ground glass opacities in the right lower lobe close to the pleura and resorption after the treatment. | 2020-05-12 |
| 32381264 | We recently reported a high cumulative incidence of thrombotic complications in critically ill patients with COVID-19 admitted to the intensive care units (ICUs) of three Dutch hospitals. […] In the competing risk model, chronic anticoagulation therapy at admission was associated with a lower risk of the composite outcome (Hazard Ratio [HR] 0.29, 95%CI 0.091-0.92). | 2020-05-11 |
| 32381426 | The reasons for hospitalization were: surgical treatment of cancer (n=5), complex emergencies (n=5), treatment of complications linked to cancer or its treatment (n=3), gastroplasty (n=1), and stoma closure (n=1). | 2020-05-11 |
| 32382072 | Carmofur inhibits viral replication in cells (EC50 = 24.30 μM) and is a promising lead compound to develop new antiviral treatment for COVID-19. | 2020-05-08 |
| 32382873 | Currently, there is still no licensed specific antiviral treatment for the human coronavirus disease and a vaccine will not be ready soon. […] However, based on experience from the use of other antiviral agents to treat similar virusses, some treatment options have been tried with some efficacy. | 2020-05-11 |
| 32382932 | For the treatment of emergency patients aside from routine epidemic prevention measures, some special measures for oral treatment need to be added. […] From January 23, 2020, to March 2, 2020, a total of 3035 patients received oral therapy during the COVID-19 epidemic in our hospital. […] To our knowledge, no oral health worker or patient has been infected with COVID-19 due to oral treatment, and no patients have complained about the suspension of treatment by complaints hotline. | 2020-05-30 |
| 32383125 | We describe the design of a clinical trial of hydroxychloroquine for post-exposure prophylaxis (PEP) and pre-emptive therapy (PET) for COVID-19. | 2020-05-11 |
| 32383183 | The convalescent plasma containing a high level of SARS-CoV-2 immunoglobulin G (IgG) antibody has been used in clinical therapy and achieved good effects in China. | 2020-05-23 |
| 32383234 | Associated symptoms, latency time, treatment, and prognosis were also carefully summarized. | 2020-05-22 |
| 32383284 | The patient was subsequently discharged on medical therapy but returned 3 days later due to worsening chest pain. | 2020-05-08 |
| 32383430 | Currently, there is no available treatment proven to be effective against COVID-19, but multiple medications, including hydroxychloroquine (HCQ), are used off label. […] We report the case of a 60-year-old woman without any cardiac history who developed right bundle brunch block and critically prolonged corrected electrocardiographic QT interval (QTc 631 ms) after treatment for 3 days with HCQ, which resolved on discontinuation of the medication. | 2020-05-08 |
| 32383530 | However, many clinicians feel ill equipped to deliver therapy via telehealth, while adhering to evidence-based interventions. […] Seventy clinical colleagues of the authors were emailed and invited to share their concerns online about how to deliver cognitive-behavioral therapy for eating disorders (CBT-ED) via telehealth, and how to adapt clinical practice to deal with the problems that they and others had encountered. | 2020-05-08 |
| 32383624 | The hypothesis has been proposed that patients COVID-19 positive, under anti-hypertensive treatment with angiotensin enzyme inhibitors or angiotensin receptor-blockers, might have a worse or a better clinical prognosis. | 2020-05-08 |
| 32384004 | The Novel Coronavirus SARS-CoV-2 (COVID-19) pandemic is changing how we deliver expert palliative care. […] Isolation of patients, limitation of visitors and interdisciplinary support, and changes in nursing and provider assessment have all had their impact on how we deliver palliative care. | 2020-05-08 |
| 32384045 | Using these markers for early identification of patients with severe disease may help healthcare providers prioritize the need to obtain therapy. | 2020-05-08 |
| 32384183 | Rapid identification of the haemophilia status, undelayed and regular liaison with the haemophilia team, proper therapy with factor concentrates or alternative treatments appear instrumental to prevent haemophilia-related complications in this setting. | 2020-05-08 |
| 32384227 | Although data are scarce at this stage, there is also an unexplained increased prevalence of obesity in patients infected with SARS-CoV-2 admitted to the intensive care units (ICU) (2). | 2020-05-08 |
| 32384516 | While several companies have already begun vaccine trials and healthcare facilities have been using a wide-range of medications to treat the virus and symptoms, there is not yet an approved medication regimen for COVID-19 infections. | 2020-05-13 |
| 32384798 | Systemic ozone therapy (OT) could be potentially useful in the clinical management of several complications secondary to SARS-CoV-2. | 2020-05-11 |
| 32384917 | Veno-venous extracorporeal membrane oxygenation (V-V ECMO) may serve as life-saving rescue therapy for refractory respiratory failure in the setting of acute respiratory compromise such as that induced by SARS-CoV-2. | 2020-05-13 |
| 32385132 | Therefore, patients with nervous system involvement as the presenting symptoms in the early stage of infection may easily be misdiagnosed and their treatment delayed. | 2020-05-14 |
| 32385187 | Many of these changes unfolded over days, including removing residents from outpatient services, minimizing the number of residents on inpatient services, deploying residents to medicine services and medical intensive care units, converting continuity clinic patient visits to virtual options, transforming didactics to online platforms only, and maintaining connectedness in an era of social distancing. | 2020-05-29 |
| 32385225 | With regard to the management of pregnant COVID-19 patients, in addition to the treatment of the infection itself, which is not that different from generally accepted principles, it is interesting to consider which obstetric procedures should be used to minimize the adverse effects on mother and child. | 2020-05-12 |
| 32385458 | To facilitate any move towards the resumption of widespread dental treatment, possibly without mass vaccination or the widespread use of antibody testing, the aerosol issue will need to be addressed and solved. | 2020-05-13 |
| 32385628 | Although the generalized advice to quit smoking as a measure to reduce health risk remains valid, the findings, together with the well-established immunomodulatory effects of nicotine, suggest that pharmaceutical nicotine should be considered as a potential treatment option in COVID-19. | 2020-05-14 |
| 32385672 | In this comprehensive review, we discuss the impact of COVID-19 on health and the immune system of those affected, reviewing the latest treatment approaches and ongoing clinical trials. | 2020-05-12 |
| 32385712 | SPMs also promote anti-viral B cell antibodies and lymphocyte activity, highlighting their potential use in the treatment of COVID-19. | 2020-05-14 |
| 32385829 | There is no proven medication for its treatment, so, all of the medications used for treatment are considered to be off-label. | 2020-05-14 |
| 32385859 | Psoriasis treatment relies on immunosuppression, and although most experts agree that the benefit-to risk-ratio is in favor of maintaining selective biologic therapies, and small molecules such as apremilast, they recommend dismission if severe COVID-19 symptoms occur. | 2020-05-09 |
| 32385891 | In this quick review we have analyzed the mechanisms of action and related infective risk of drugs used for the treatment of immune-mediated and oncologic skin conditions during the daily clinical practice. […] In the case of a COVID19 patient with complication (such as pneumonia, respiratory failure), treatment suspension should always be considered after taking into account the general condition of the patient, the risk-benefit ratio and the pathophysiology of COVID19 infection. […] The COVID19 emergency pandemic does not imply an under-treatment of existing skin conditions, which together with the SARS-Cov2 infection may jeopardize the patient’s life. | 2020-05-09 |
| 32385982 | Many phenomena and problems in the work of epidemic prevention, control and treatment are worthy of our deep reflection. | 2020-05-12 |
| 32385985 | The outbreak of coronavirus disease 2019 (COVID-19) is serious and there is no effective treatment to date. […] In order to reduce the mortality of severe and critical COVID-19, experts from the first-line in related fields in China were organized to analyze, discuss and summarize the diagnosis and treatment of severe and critical COVID-19 patients in Wuhan and other severe epidemic areas, and formulate the expert consensus. | 2020-05-12 |
| 32385990 | To discuss the research progress in the field of coronavirus (CoVs) treatment based on the visualization analysis of knowledge graph. […] The related literatures in the field of CoVs treatment were retrieved from the establishment of Web of Science core collection database to February 15th, 2020, and the literature analysis tool of Web of Science database was used to count the annual trend of published literatures. […] In terms of literature volume, the literatures on CoVs therapy rose after 2003 and 2012, and the number of published literatures had remained high since 2014. […] In terms of countries, the main countries that carried out the research on the treatment of CoVs were the United States (n = 613), China (n = 582), Germany (n = 122), Canada (n = 99), etc., and the cooperation among countries was close. […] In terms of institutions, the number of papers issued by Chinese Academy of Sciences in the field of CoVs treatment ranked first (n = 82), followed by University of Hong Kong of China (n = 74) and Chinese University of Hong Kong of China (n = 58), followed by National Institute of Allergy and Infectious Diseases (n = 37), and the cooperation among various institutions was close. […] The treatment hot spots focused on preventing virus adsorption, inhibiting the virus gene nucleic acid replication, transcription and translation. […] Through the visualization analysis of knowledge graph, the development trend and hot spots of CoVs therapy research could be well observed. […] In this study, the degree of attention in the field of CoVs treatment showed periodic changes, related to the outbreak of new CoVs, and the country, institutions and the author were closely related. […] The treatment hot spots focused on preventing virus adsorption, inhibiting the virus gene nucleic acid replication, transcription and translation in order to develop new targets of drug. | 2020-05-12 |
| 32386011 | There is no specific treatment so far. | 2020-05-13 |
| 32386013 | All patients had absorbed lesions on follow-up CT images after treatment. | 2020-05-13 |
| 32386015 | To determine imaging features of coronavirus disease 2019 (COVID-19) in different stages, and to provide foundations for early diagnosis and treatment. | 2020-05-13 |
| 32386018 | Early screening, early diagnosis, early isolation, and early treatment remain the most effective prevention and control measures. […] Computed tomography (CT) plays a vital role in the screening, diagnosis, treatment, and follow-up of COVID-19, especially in the early screening, with a higher sensitivity than that of real-time fluorescence RT-PCR. | 2020-05-13 |
| 32386027 | Significant improvement regarding the pathogenesis, epidemiology, and diagnosis and therapy for the COVID-19 has been achieved to stop the spread of the epidemics. | 2020-05-13 |
| 32386125 | The C19-GRA launched an international, secure, de-identified physician registry of patients with rheumatic diseases infected with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) to provide insights into the management and treatment of COVID-19 in this population. | 2020-05-09 |
| 32386431 | We have read with great interest the letter of the European Task Force on Atopic Dermatitis (ETFAD) on SARS-CoV-2-infection and atopic dermatitis published in JEADV (March 2020)1 in which the authors state: “Targeted treatment selectively interfering with type-2 inflammation such as dupilumab is not considered to increase the risk for viral infections and might thus be preferred …in a situation such as COVID-19 pandemic”.1. | 2020-05-09 |
| 32386441 | The Public Health Agency of Sweden has analysed how many pregnant and postpartum women with SARS-CoV-2 infection have been treated in intensive care units (ICU) in Sweden between the March 19 and April 20, 2020, compared with non-pregnant women of similar age. | 2020-05-09 |
| 32386448 | The antimalarials, Chloroquine and Hydroxychloroquine (HCQ), and the antivirals Lopinavir/Ritonavir have been recently recorded as having anti-severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) effects.1 In particular, regarding Italy, one of the countries most affected by the pandemic, the Italian Society of Infectious and Tropical disease (Lombardy section) has recommended the use of HCQ for treatment of coronavirus disease 2019 (COVID-19). | 2020-05-09 |
| 32386460 | It is a mildly symptomatic condition with an excellent prognosis, usually requiring no therapy. | 2020-05-23 |
| 32386514 | No intervention has yet been proven effective for the treatment of COVID-19. […] We will include randomized clinical trials comparing any intervention for the treatment of COVID-19 (e.g., pharmacological interventions, fluid therapy, invasive or noninvasive ventilation, or similar interventions) with any comparator (e.g., an “active” comparator, standard care, placebo, no intervention, or “active placebo”) for participants in all age groups with a diagnosis of COVID-19. […] Secondary outcomes will be admission to intensive care, mechanical ventilation, renal replacement therapy, quality of life, and non-serious adverse events. […] This review will continuously inform best practice in treatment and clinical research of this highly prevalent disease. | 2020-05-13 |
| 32386567 | Hence, surgical candidates face prolonged delays of beneficial treatment. | 2020-05-29 |
| 32386712 | We as a surgical community should herald their examples and re-focus our efforts to pioneer investigations into the coronavirus, helping elucidate the biology, understand its social effects, and provide effective treatment regimens for the disease. | 2020-05-14 |
| 32386848 | The direct and indirect effects of Coronavirus Disease-19 (COVID-19) pandemic, on Italian patients with lysosomal storage disorders receiving therapy, were analyzed by a phone questionnaire. […] Forty-nine% of patients receiving enzyme replacement therapy in hospitals experienced disruptions, versus 6% of those home-treated. | 2020-05-14 |
| 32386875 | Cancer therapy is complex, and outcomes are centered on timing. | 2020-05-14 |
| 32386911 | Highly immunosuppressive chemotherapy regimens and possible exposure to COVID-19 during treatment may put patients at additional risk. […] An expert panel convened to develop initial consensus guidelines regarding anti-neoplastic therapy during the COVID-19 pandemic with respect to gynecologic cancer care and clinical trials. | 2020-05-14 |
| 32387014 | Chlorpromazine (CPZ) is a phenothiazine derivative widely used in clinical routine in the treatment of acute and chronic psychoses. […] This first antipsychotic medication has been discovered in 1952 by Jean Delay and Pierre Deniker at Sainte-Anne hospital. […] The main objective is to demonstrate a shorter time to response (TTR) to treatment in the CPZ+standard-of-care (CPZ+SOC) group, compared to the SOC group. […] Response to treatment is defined by a reduction of at least one level of severity on the WHO-Ordinal Scale for Clinical Improvement (WHO-OSCI). […] CRP and lymphopenia); (D) a greater decrease in parenchymal involvement (chest CT) on the seventh day post-randomization; (E) to define the optimal dosage of CPZ and its tolerance; (F) to evaluate the biological parameters of response to treatment, in particular the involvement of inflammatory cytokines. […] This CPZ repositioning strategy also avoids numerous developmental and experimental steps and can save precious time to rapidly establish an anti-COVID-19 therapy with well-known, limited and easy to manage side effects. […] The broad spectrum of CPZ treatment - including antipsychotic, anxiolytic, antiemetic, antiviral, immunomodulatory effects along with inhibition of clathrin-mediated endocytosis and modulation of blood-brain barrier - is in line with the historical French commercial name for CPZ, i.e. | 2020-05-14 |
| 32387040 | Sofosbuvir active metabolite, however, shows an extremely high intracellular stability So, it is hypothesized that SARS-CoV-2 infection could also be susceptible to sofosbuvir and we were convinced to design and run a clinical trial to evaluate the effect of sofosbuvir 400 mg (in combination with velpatasvir 100 mg, as add-on treatment, in addition to standard of care) on the COVID-19. | 2020-05-17 |
| 32387041 | This case highlights a problematic ethical double standard in multinational clinical research: trials that would be considered unethical in high income countries (e.g., placebo-controlled where there is an existing treatment) are nonetheless justified in low-and-middle-income countries because the existing standards of care are less (i.e., no access to a treatment). | 2020-05-14 |
| 32387058 | This is particularly so for peritoneal neoplastic diseases, for which curative treatment mobilizes substantial personnel, operating room and intensive care resources. […] It is desirable to prioritize disease conditions for which cytoreduction surgery with or without associated hyperthermic intraoperative peritoneal chemotherapy (HIPEC) is the gold-standard treatment, and for which systemic chemotherapy cannot be a temporary or long-term alternative: pseudomyxoma peritonei, resectable malignant peritoneal mesotheliomas, peritoneal metastases of colorectal origin if they are resectable and unresponsive to systemic chemotherapy after up to 12 courses, first-line ovarian carcinomatosis if resectable or in interval surgery after at most six courses of systemic chemotherapy. | 2020-05-22 |
| 32387061 | However, the very nature of acute lymphoblastic leukemias and their treatment in children and adolescents led the Leukemia Committee of the French Society for the fight against cancers and leukemias in children and adolescents (SFCE) to propose more specific recommendations, even if data for this population are still scarce. | 2020-05-24 |
| 32387139 | The current coronavirus disease 2019 (COVID-19) pandemic has put significant strain on all aspects of health care delivery, including palliative care services. | 2020-05-26 |
| 32387230 | Amid the growing burden of the pandemic, there are parallel emergencies that need to be simultaneously tackled: the proliferation of fake medicines, fake news and medication misinformation surrounding COVID-19. […] Primarily, they can be a relevant source of accurate and reliable information to the public or other fellow health professionals thereby reducing the spread of COVID-19 medication misinformation. | 2020-05-29 |
| 32387246 | Where the diagnosis remains uncertain, an endomyocardial biopsy may help identify active cardiac infection through viral genome amplification and possibly refine the treatment risks of systemic immunosuppression. | 2020-05-14 |
| 32387247 | Many of the drugs being used in the treatment of the ongoing pandemic coronavirus disease 2019 (COVID-19) are associated with QT prolongation. | 2020-05-14 |
| 32387301 | A possible combined treatment algorithm for COVID-19 is here proposed. | 2020-05-30 |
| 32387320 | No therapy has yet proven effective in COVID-19. […] Tocilizumab (TCZ) in patients with severe COVID-19 could be an effective treatment. […] Patients with TCZ (n=20) had a higher Charlson comorbidity index (5.3 [±2.4] vs 3.4 [±2.6], P=0.014), presented with more severe forms (higher level of oxygen therapy at 13L/min vs 6L/min, P<0.001), and had poorer biological findings (severe lymphopenia: 676/mm3 vs 914/mm3, P=0.037 and higher CRP level: 158mg/L vs 105mg/L, P=0.017) than patients without TCZ (n=25). | 2020-05-17 |
| 32387332 | In this review, we describe some currently applied diagnostic approaches, as well as therapeutics and vaccines, to prevent, treat and control further outbreaks of SARS-CoV-2 infection. | 2020-05-16 |
| 32387409 | In France, the combination hydroxychloroquine (HCQ) and azithromycin (AZ) is used in the treatment of COVID-19. | 2020-05-16 |
| 32387456 | The parameters used for each COVID-19 positive patient were gender, hospitalization, admission to intensive care unit (ICU), death, tumor diagnosis, prostate cancer diagnosis, and androgen-deprivation therapy (ADT). | 2020-05-14 |
| 32387574 | Bereavement care is considered an integral component of quality end-of-life care endorsed by the palliative care movement. […] In this article, drawing on the palliative care and bereavement literature, we offer suggestions about how to incorporate palliative care tools and psychological strategies into bereavement care for families during this pandemic. | 2020-05-30 |
| 32387575 | These medicines, essential to palliative care, are regulated under the international drug control conventions overseen by United Nations (UN) specialized agencies and treaty bodies and under national drug control laws. […] This paper describes the issues related to the lack of availability and limited access to ICEMs during the COVID-19 pandemic in both intensive and palliative care patients in countries of all income levels and makes recommendations for improving access. | 2020-05-14 |
| 32387694 | While approved specific antiviral drugs against SARS-CoV-2 are still lacking, a large number of existing drugs are being explored as a possible treatment for COVID-19 infected patients. […] In an attempt to explore the evidence that supports their use in COVID-19 patients, we comprehensively reviewed the previous studies which used CQ or HCQ as an antiviral treatment. […] Given the current uncertainty, it is worth being mindful of the potential risks and strictly rationalise the use of these drugs in COVID-19 patients until further high quality randomized clinical trials are available to clarify their role in the treatment or prevention of COVID-19. | 2020-05-22 |
| 32387778 | In the current work, SARS-CoV-2 RNA was concentrated from wastewater in a catchment in Australia and viral RNA copies were enumerated using reverse transcriptase quantitative polymerase chain reaction (RT-qPCR) resulting in two positive detections within a six day period from the same wastewater treatment plant (WWTP). | 2020-05-19 |
| 32388330 | Early insulin therapy seems very promising in alleviating lung injury. | 2020-05-27 |
| 32388331 | On the contrary, direct β-cell damage, cytokine-induced insulin resistance, hypokalemia and drugs used in the treatment of COVID-19 (like corticosteroids, lopinavir/ritonavir) can contribute to worsening of glucose control in people with diabetes mellitus. | 2020-05-27 |
| 32388333 | IoT implementation impacts on reducing healthcare cost and improve treatment outcome of the infected patient. […] IoT is helpful for an infected patient of COVID-19 to identify symptoms and provides better treatment rapidly. | 2020-05-27 |
| 32388451 | Development of PML or other serious opportunistic infections during treatment with natalizumab forces to consider whether de-risking strategies are needed in this particular context and how to manage a high-efficacy treatment. […] This case supports the opportunity to avoid discontinuing or delaying the retreatment over 8 weeks in patients recovered from a recent COVID-19. | 2020-05-27 |
| 32388458 | They were receiving treatment with either amantadine (n=15) or memantine (n=7) in stable registered doses. | 2020-05-26 |
| 32388486 | The evidence shows that violet/blue (400-470 nm) light is antimicrobial against numerous bacteria, and that it accounts for Niels Ryberg Finsen’s Nobel-winning treatment of tuberculosis. | 2020-05-27 |
| 32388805 | Due to the current lack of effective pharmacological concepts, this situation has caused interest in (re)considering historical reports on the treatment of patients with low-dose radiation therapy for pneumonia. […] Although these historical reports are of low-level evidence per se, hampering recommendations for decision-making in the clinical setting, they indicate effectiveness in the dose range between 0.3 and 1 Gy, similar to more recent dose concepts in the treatment of acute and chronic inflammatory/degenerative benign diseases with, e.g., a single dose per fraction of 0.5 Gy. […] This concise review aims to critically review the evidence for low-dose radiation treatment of COVID-19 pneumopathy and discuss whether it is worth investigating in the present clinical situation. | 2020-05-14 |
| 32388880 | The neurological symptoms improved significantly during treatment with immunoglobulins. | 2020-05-26 |
| 32388937 | Objective: To evaluate the efficacy and safety of lopinavir/ritonavir (LPV/r) and arbidol in the treatment of COVID-19 in the real world. Methods: The clinical data of 178 patients diagnosed with COVID-19 admitted to Guangzhou Eighth People’s Hospital were retrospectively analyzed from January 21 to February 9, 2020. […] According to the patient’s antiviral treatment regimen, 178 patients were divided into 4 groups including LPV/r group (59 patients), arbidol group (36 patients), combination therapy with LPV/r plus arbidol group (25 patients) and the conventional treatment group without any antiviral drugs (58 patients). […] The main observation end points of the study was the negative conversion time of nucleic acid of the novel coronavirus (2019-nCoV) in pharyngeal swab. Results: The baseline of 4 groups before treatment was consistent and comparable. […] The negative conversion time of nucleic acid of the 2019-nCoV in pharyngeal swab was (10.20 ± 3.49), (10.11 ± 4.68), (10.86 ± 4.74), (8.44 ± 3.51) days separately in the LPV/r group, the arbidol group, the combination therapy group, and the conventional treatment group without significant difference (F = 2.556, P = 0.058). […] However, a statistically significant difference was found in the proportion of deterioration changing from mild/moderate to severe/critical type at day 7 (χ(2) = 9.311, P = 0.017) as follows: the combination therapy group (24.0%, 6/25), the arbidol group ( 16.7%, 6/36), LPV/r group (5.4%, 3/56) and conventional treatment group (5.2%, 3/58). […] Moreover, the frequency of adverse reactions in the three groups receiving antiviral drugs was significantly higher than that in the conventional treatment group (χ(2) = 14.875, P = 0.002). Conclusions: No evidences could prove that LPV/r and arbidol could shorten the negative conversion time of novel coronavirus nucleic acid in pharyngeal swab nor improve the symptoms of patients. […] Noteworthy, the adverse reactions of the antiviral drugs should be paid careful attention during the treatment. 目的： 评价真实世界中洛匹那韦/利托那韦（LPV/r）及阿比多尔治疗新型冠状病毒肺炎（COVID-19）的疗效和安全性。 | 2020-05-10 |
| 32388947 | Among the 7 patients, 1 case died of (B) aggravation, and the other patients’ condition was effectively controlled after active treatment. | 2020-05-12 |
| 32389025 | Because of its higher potency and better safety profile, hydroxychloroquine may be the more reasonable treatment option if treatment is initiated. | 2020-05-21 |
| 32389318 | In addition, staff illness and restructuring of services to deal with the crisis will inevitably place treatment capacities under significant strain. | 2020-05-13 |
| 32389492 | For the first time, faced with a crisis with an exceptional magnitude due to the COVID-19 pandemic responsible for saturation of emergency services and intensive care units, the urolithiasis committee of the French Urology Association designed the recommendations for care and treatment of stone-forming patients and their treatment during crisis. | 2020-05-14 |
| 32389518 | Patients on renal replacement therapy (RRT) have not been unaware of this situation and due to their characteristics they are especially vulnerable. […] A very high percentage (85%) required hospital admission, 8% in intensive care units. | 2020-05-14 |
| 32389538 | Surgical tracheostomies have a role in the weaning process of COVID-19 patients treated in intensive care units. | 2020-05-15 |
| 32389618 | She was given atomization inhalation therapy with recombinant human interferon alfa-1b for 10 days. | 2020-05-17 |
| 32389631 | Pharmacists have long been involved in public health and emergency preparedness and response (EP&R), including through preventive measures such as screening, vaccinations, testing, medical and pharmaceutical countermeasures, as well as ensuring medication safety and access during natural disasters and pandemics. | 2020-05-15 |
| 32389695 | The pandemic is exposing, with terrible clarity, the disparities in human society-racism,6 poverty,7,8 domestic violence,9,10 and child maltreatment and neglect11-and tragically will likely amplify the negative impacts that each has on child development and mental health. | 2020-05-30 |
| 32389697 | In this paper, we report the results of plasmapheresis treatment in a series of severely ill patients with COVID-19-related autoimmune meningoencephalitis in the Intensive Care Unit (ICU). | 2020-05-18 |
| 32389755 | In addition to making practice changes to cope with the adverse realities, oncologists should also work together to raise pragmatic suggestions to policy makers and be strong advocates to protect our patients from the detrimental effect of delay or compromised treatment. | 2020-05-31 |
| 32389859 | We discuss the implications of COVID-19 infections for FH patients, the importance of continuing lipid-lowering therapy where possible, issues relating to safety monitoring and service delivery. | 2020-05-31 |
| 32389940 | With the explosive growth of confirmed cases, emergency medical supplies are facing global shortage, which restricts the treatment of seriously ill patients and protection of medical staff. | 2020-05-11 |
| 32390367 | All patients received antibiotic therapy, and most (97/98 patients; 99.0%) received antiviral therapy (lopinavir/ritonavir). […] Hydroxychloroquine was used in 79 patients (80.6%), and glucocorticoid therapy was used in 18 patients (18.4%). | 2020-05-12 |
| 32390971 | We will discuss the potential of AAV-based gene therapy technology for in vivo therapeutic antibody delivery to combat SARS-CoV-2 outbreak and the future emergence of severe CoVs. | 2020-05-15 |
| 32391169 | During infection and its complication such as sepsis, hypotension could be exacerbated by antihypertensive drugs because homeostasis mechanisms such as sodium balance, renin angiotensin aldosterone system and/or sympathetic nervous system can be mitigated by antihypertensive drug therapy. | 2020-05-15 |
| 32391234 | We describe the clinical presentation of this patient, the diagnostic process, the laboratory and imaging investigations, as well as the course of treatment. | 2020-05-15 |
| 32391242 | Precision medicine (PM) represents a new paradigm in disease diagnosis, prevention, and treatment. […] Better understanding of pathogenic pathways together with an accurate phenotype classification of patients presented with SARS-CoV-2 infection and symptoms might contribute to a more accurate definition of biomarkers and other diagnostic tools, which may lead to more precise mitigation strategies, personalized pharmacologic options, as well as new biological therapy developments. | 2020-05-15 |
| 32391282 | In this historical moment, medical oncologists are required to consider the possibility to delay active treatment administration based on a case-by-case risk/benefit evaluation. […] Potential risks associated with COVID-19 infection should be considered, considering tumor histology and natural course, disease setting, clinical conditions, and disease burden, together with the expected benefit, toxicities (e.g., myelosuppression or interstitial lung disease), and response obtained from the planned or ongoing treatment. […] Proactive management and containment measures, applied in a structured and daily way, has significantly aided the identification of advance patients with suspected symptoms related to COVID-19, limiting their admission to our cancer center; we have thus been more able to protect other patients from possible contamination and at the same time guarantee to the suspected patients the immediate treatment and evaluation in referral hospitals for COVID-19. | 2020-05-15 |
| 32391308 | Furthermore, given that a relevant proportion of infected people need hospitalization in Intensive Care Units, this may be a crucial issue for National Healthcare System’s capacity. | 2020-05-15 |
| 32391369 | The aim was to investigate the effectiveness of glucocorticoid therapy in patients with COVID-19. | 2020-05-15 |
| 32391519 | Treatment and neonatal outcomes are also reported. | 2020-05-11 |
| 32391657 | Early identification, early isolation, early diagnosis and early treatment are important for clinical management. […] The treatment of mild or moderate type of child COVID-19 is mainly symptomatic. […] For severe and critical ill cases, the oxygen therapy, antiviral drugs, antibacterial drugs, glucocorticoids, mechanical ventilation or even extracorporeal membrane oxygenation (ECMO) may be adopted, and the treatment plan should be adjusted timely through multi-disciplinary cooperation. | 2020-05-12 |
| 32391658 | Based on the present expert consensus carried out by National Health Commission and National Administration of Traditional Chinese Medicine, our team summarized and established an effective treatment strategy centered on “Four-Anti and Two-Balance” for clinical practice. […] Meanwhile, integrated multidisciplinary personalized treatment was recommended to improve therapeutic effect. […] Early antiviral treatment could alleviate disease severity and prevent illness progression, and we found lopinavir/ritonavir combined with abidol showed antiviral effects in COVID-19. […] The artificial liver blood purification system could rapidly remove inflammatory mediators and block cytokine storm.Moreover, it also favored the balance of fluid, electrolyte and acid-base and thus improved treatment efficacy in critical illness. […] Conservative oxygen therapy was preferred and noninvasive ventilation was not recommended. […] We also integrated Chinese medicine in treatment to promote disease rehabilitation through classification methods of traditional Chinese medicine. […] However, since COVID-19 was a newly emerging disease, more work was warranted to improve strategies of prevention, diagnosis and treatment for COVID-19. | 2020-05-12 |
| 32391659 | Severe and critically ill patients with coronavirus disease 2019 (COVID-19) were usually with underlying diseases, which led to the problems of complicated drug use, potential drug-drug interactions and medication errors in special patients. […] Based on Diagnosis and treatment of novel coronavirus pneumonia (trial version 6), and Management of COVID-19: the Zhejiang experience, we summarized the experience in the use of antiviral drugs, corticosteroids, vascular active drugs, antibacterial, probiotics, nutrition support schemes in severe and critically ill COVID-19 patients. […] It is also suggested to focus on medication management for evaluation of drug efficacy and duration of treatment, prevention and treatment of adverse drug reactions, identification of potential drug-drug interactions, individualized medication monitoring based on biosafety protection, and medication administration for special patients. | 2020-05-12 |
| 32391661 | By using Euler integral algorithm to solve the modified SEIR dynamics model, the epidemic situation in Hubei province was analyzed, and the impact of prevention and control measures such as quarantine and centralized treatment on the epidemic development was discussed. […] Theoretical analysis showed that prevention and control quarantine and medical follow-up quarantine played an important inhibitory effect on the outbreak of the epidemic.The centralized treatment played a key role in the rapid decline in the number of infected people. | 2020-05-12 |
| 32391663 | The chest CT images of patients with COVID-19 have certain characteristics with dynamic changes, which are of value for monitoring disease progress and clinical treatment. | 2020-05-12 |
| 32391664 | A total of 67 patients diagnosed as COVID-19 by nucleic acid testing were collected and divided into 4 groups according to the clinical stages based on Diagnosis and treatment of novel coronavirus pneumonia (trial version 6). | 2020-05-12 |
| 32391665 | During the isolation treatment of suspected COVID-19 patients, early psychological intervention should be carried out for the female patients with known contact history of epidemic area and personnel in epidemic area, and drug treatment should be given in advance if necessary. | 2020-05-12 |
| 32391666 | To analyze the roles of multidisciplinary team (MDT) in the diagnosis and treatment of suspected cases of coronavirus disease 2019 (COVID-19). […] With the guidance of MDT, one COVID-19 patient was transferred to designated provincial hospital after effective treatment; one patient complicated with acute cholecystitis underwent gallbladder puncture and drainage; and COVID-19 was excluded in a highly suspected patient after alveolar lavage fluid examination. […] The efficiency of diagnosis and treatment for suspected COVID-19 patients can be improved with MDT, particularly for complicated cases. | 2020-05-12 |
| 32391667 | To evaluate the efficacy and safety of hydroxychloroquine (HCQ) in the treatment of patients with moderate coronavirus disease 2019 (COVID-19). […] We prospectively enrolled 30 treatment-naïve patients with confirmed COVID-19 after informed consent at Shanghai Public Health Clinical Center. […] Patients in HCQ group were given HCQ 400 mg per day for 5 days plus conventional treatments, while those in the control group were given conventional treatment only. […] One patient in HCQ group developed to severe during the treatment. […] Larger sample size study are needed to investigate the effects of HCQ in the treatment of COVID-19. | 2020-05-12 |
| 32391668 | To investigate the effect of corticosteroids therapy on the inflammatory response in a critically ill coronavirus disease 2019 (COVID-19) patient. […] Thereafter, the dose was adjusted in a timely manner and the therapy lasted for 13 days. | 2020-05-12 |
| 32391669 | To observe the clinical effect of plasma exchange and tocilizumab in treatment of patients with severe coronavirus disease 2019 (COVID-19). […] The C-reactive protein (CRP) and IL-6 levels were significantly decreased and the lymphocyte and prothrombin time were improved in 3 patients after treatment with plasma exchange; while inflammation level was not significantly decreased, and lymphocyte and prothrombin time did not improve in 3 patients treated with tocilizumab. | 2020-05-12 |
| 32391670 | We applied HFNC for oxygen therapy in severe and critical ill COVID-19 patients and summarized the following experiences. […] Thirdly, to avoid hypoxia or hypoxemia, the treatment goal of HFNC should be maintained the oxygen saturation (SpO2) above 95% for patients without chronic pulmonary disease. […] Finally, patients should wear a surgical mask during HFNC treatment to reduce the risk of virus transmission through droplets or aerosols. | 2020-05-12 |
| 32391671 | The report shows that COVID-19 in pregnancy women could be cured with active treatment, and the maternal and fetal outcomes can be satisfactory. | 2020-05-12 |
| 32391672 | The inflammation indicators and fever of this patient were effectively controlled and the lung lesions remained stable after active anti-viral treatment, then the radical colorectomy was performed after the viral negative conversion for twice. | 2020-05-12 |
| 32391675 | To analysis the medication characteristics of the prescriptions issued via open channel by the National and Provincial Health Committee and the State Administration of Traditional Chinese Medicine in treating coronavirus disease 2019 (COVID-19). […] We collected the data of traditional Chinese medicine related to treatment plans published by the National and Provincial Health Committee and the State Administration of Traditional Chinese Medicine from the start of COVID-19 outbreak to February 19, 2020. […] The study collected 4 national and 34 regional prevention and treatment plans, 578 items, 84 traditional Chinese formulations, 60 Chinese patent medicines, and 230 Chinese herbs. […] The main medication characteristics are clearing heat, entilating lung, removing toxicity and removing turbidity. | 2020-05-12 |
| 32391741 | Overall, the most common CT findings were ground glass opacity (114/119, 96%) and consolidation (47/119,40%). 29/119 (24%) patients required major interventions (vasopressor medication or intubation) and 27/119 (23%) died. | 2020-05-11 |
| 32391877 | Clinical, laboratory, and treatment data were collected and compared between patients who died and survivors. | 2020-05-29 |
| 32391999 | Since the outbreak of COVID-19, chloroquine has been mentioned as a possible treatment. […] Recently, the Dutch National Institute for Public Health and the Environment published treatment options for antiviral treatment for COVID-19 where chloroquine was suggested as first choice for off-label treatment, beside remdesivir en lopinavir/ritonavir. | 2020-05-20 |
| 32392007 | The current guidelines for diagnosis and treatment of primary respiratory infections are still useful during the COVID-19 epidemic.Telephone triage of patients with respiratory complaints aims to identify patients with complications or an increased risk of complications.There are no indications to test for SARS-CoV-2 virus in general practice.During this COVID-19 epidemic, protective clothing is recommended in all physical contacts with patients with respiratory complaints.There is no reason to be cautious about using NSAIDs in patients suspected of COVID-19. […] Amoxicillin is first choice treatment for respiratory infections during the COVID-19 epidemic; there is lack of evidence to support azithromycin as a first choice.Respiratory rate > 24 / min or saturation <92-94% indicate imminent respiratory decompensation and may be reasons for referral. | 2020-05-20 |
| 32392282 | Among patients hospitalized in metropolitan New York with COVID-19, treatment with hydroxychloroquine, azithromycin, or both, compared with neither treatment, was not significantly associated with differences in in-hospital mortality. | 2020-05-20 |
| 32392288 | While there is evidence that the burden of COVID-19 infection in hospitalized children is lesser than in their adult counterparts, to date, there are only limited reports describing COVID-19 in pediatric intensive care units (PICUs). | 2020-05-11 |
| 32392333 | A breakdown of treatment and prevention services for these conditions may even overshadow the projected morbidity and mortality from COVID-19. | 2020-05-29 |
| 32392473 | Diabetes-related factors of glycemic control, medication pharmacodynamics, and insulin access can impact the severity of a COVID-19 infection. | 2020-05-18 |
| 32392559 | The biology of each leukemia and its corresponding treatment with conventional intensive chemotherapy, with or without targeted therapies (venetoclax, FLT3 inhibitors, IDH1/2 inhibitors, Bruton’s tyrosine kinase inhibitors), introduce additional layers of complexity during COVID-19 high-risk periods. | 2020-05-11 |
| 32392562 | However, more studies are needed to clarify the efficacy of these therapeutics. […] In addition to antiviral therapy, potential ACE2- and AT1-R-inhibiting strategies, and other supportive care, we suggest other potential JAKinibs and novel anti-inflammatory combination therapies that affect the JAK-STAT pathway in patients with COVID-19. | 2020-05-11 |
| 32392624 | A group was formed, comprising three senior geriatricians, a former dean, a palliative care specialist, and a lawyer/ethicist. […] Recommendations included the approach to older persons both in the community and in long-term care institutions, a triage instrument, and palliative care. […] The guideline emphasized that no matter what, in the spirit of beneficence, anyone who fell ill must receive active palliative care throughout the course of a COVD-19 infection but especially at the end of life. | 2020-05-23 |
| 32392741 | Fibrinogen seems to increase early in COVID-19 patients and may be used as a risk stratification marker for the early detection of a subgroup of COVID-19 patient at increased risk to develop SARS, who might benefit from a different and thorough clinical surveillance and treatment. | 2020-05-12 |
| 32392859 | This is an important issue to be identified in order to provide more specific therapy earlier, including both antiviral and anti-inflammatory drugs associated with anti anticoagulant therapy. | 2020-05-12 |
| 32393325 | Preparing intensive care units (ICU) is an integral part of any pandemic response. | 2020-05-13 |
| 32393381 | Perceived causes of infection, infection prevention, control knowledge and behaviour, psychological changes, symptoms and treatment were measured. | 2020-05-14 |
| 32393401 | Given its rare side effects and relatively wide safety, prophylactic vitamin D supplementation and/or food fortification might reasonably serve as a very convenient adjuvant therapy for these two worldwide public health problems alike. | 2020-05-12 |
| 32393438 | The method is a powerful tool for studying the underlying mechanism of platelet aggregation and is expected to open a window on an entirely new class of clinical diagnostics, pharmacometrics, and therapeutics. […] Blood clots have also been linked to harmful inflammation and the spread of cancer, and there are now preliminary reports of remarkably high rates of clotting in COVID-19 patients in intensive care units. […] This could help them choose whether aspirin or another anti-platelet drug would be the best treatment. | 2020-05-14 |
| 32393447 | Temporary closure of outpatient health facilities in some secondary and tertiary care hospitals have deprived millions of NCD patients of their regular medication and diagnostic health needs. | 2020-05-14 |
| 32393448 | The WHO and the FDA have not found adequate evidence to recommend any specific medication for the treatment of Covid-19. | 2020-05-14 |
| 32393594 | Management of COPD with COVID-19 warrants standard-of-care treatment with antimicrobial agents and corticosteroids, though limiting the dose and duration of steroids use may be warranted due to the risk of increased viral shedding. | 2020-05-12 |
| 32393597 | HCQ is the only SLE treatment shown to increase survival and any change in the HCQ regimen is potentially dangerous. […] Providers need to make thoughtful, informed decisions in this time of medication shortage. | 2020-05-12 |
| 32393664 | We found that the average patient receiving treatment with hydroxychloroquine for rheumatic diseases, including children and non-pregnant/pregnant adults, are unlikely to achieve total serum or plasma concentrations shown to inhibit SARS-CoV-2 in-vitro. | 2020-05-12 |
| 32393985 | Evidence of the benefits of vitamin C (VC) for the treatment of sepsis is accumulating. | 2020-05-12 |
| 32394153 | Prevention and risk reduction strategies are paramount in the current absence of effective treatment or a vaccine. | 2020-05-15 |
| 32394237 | Rarely, pulmonary embolism may be encountered in patients with severe COVID-19 infection, especially in intensive care units. | 2020-05-15 |
| 32394338 | The current coronavirus disease (COVID-19) pandemic has caused significant mortality over a short time and has necessitated an increase in provision of both critical care and palliative care. | 2020-05-15 |
| 32394344 | All patients were on antiretroviral treatment, of them 22 on tenofovir-containing regimen and 4 on the protease inhibitor darunavir. | 2020-05-15 |
| 32394416 | On the other hand, patients, who need emergency healthcare, should also be provided with appropriate treatment. […] Healthcare professionals should choose a treatment method appropriately in the circumstances to protect themselves and their patients as much as possible. | 2020-05-13 |
| 32394467 | Neuraminidase inhibitors such as oseltamivir, peramivir, and zanamivir are invalid for 2019-nCoV and are not recommended for treatment but protease inhibitors such as lopinavir/ritonavir (LPV/r) inhibit the progression of MERS-CoV disease and can be useful for patients of COVID-19 and, in combination with Arbidol, has a direct antiviral effect on early replication of SARS-CoV. […] Favipiravir increases clinical recovery and reduces respiratory problems and has a stronger antiviral effect than LPV/r. currently, appropriate treatment for patients with COVID-19 is an ACE2 inhibitor and a clinical problem reducing agent such as favipiravir in addition to hydroxychloroquine and corticosteroids. | 2020-05-12 |
| 32394481 | On March 16, 2020, the French Society of Pharmacology and Therapeutics put online a national Question and Answer (Q&A) website, https://sfpt-fr.org/covid19 on the proper use of drugs during the COVID-19 pandemic. | 2020-05-12 |
| 32394639 | The importance of DPP4 for the medical community has been highlighted by the approval of DPP4 inhibitors, or gliptins, for the treatment of type 2 diabetes mellitus. | 2020-05-27 |
| 32395064 | Due to overall rising cancer incidence and specific concerns, a cohort of cancer patients forms a distinct subset of the population in whom a correct and timely treatment has a huge impact on the outcome. | 2020-05-15 |
| 32395179 | The value of extracorporeal membrane oxygenation (ECMO) for patients suffering from novel coronavirus disease 2019 (COVID-19) as a rescue therapy for respiratory failure remains controversial and associated with high mortality rates of 50 to 82% in early reports from Wuhan, China. […] We hypothesized that patient outcomes would be improved at our tertiary cardiothoracic surgery referral center with a protocolized team-approach for ECMO treatment of patients with severe COVID-19 disease. […] Her respiratory status continued to deteriorate despite maximized critical care, including prone positioning ventilation and nitric oxide inhalation therapy. […] Veno-venous ECMO was initiated on hospital day 7 in conjunction with a 10-day course of compassionate use antiviral treatment with remdesivir. […] This case report demonstrates a positive outcome in a young patient with COVID-19 treated by the judicious application of ECMO in conjunction with compassionate use antiviral treatment (remdesivir). | 2020-05-15 |
| 32395417 | More research is required, especially in the treatment and prevention of the disease, so that we may progress towards finding a cure as well as creating a vaccine for the COVID-19. | 2020-05-15 |
| 32395418 | In this review, we will update and summarize the most common and plausible drugs for the treatment of COVID-19 patients. | 2020-05-15 |
| 32395419 | In this special Theme issue, we would like to discuss the latest treatment modalities available around the world in tackling this dreadful disease. | 2020-05-15 |
| 32395474 | Previous experimental data revealed ACE2 level was increased following treatment with ACE inhibitors (ACEIs) and angiotensin receptor blockers (ARBs). | 2020-05-15 |
| 32395542 | Also, treatment principles may various for CRC patients with or without severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, as well as patients with or without an emergency presentation. | 2020-05-15 |
| 32395550 | At last, the prognosis was good after active treatment. […] After antiviral and anti-infective treatment, the symptoms recovered. | 2020-05-15 |
| 32395606 | The strategy in virtual screening of antiviral databases for possible therapeutic effect would be to identify promising drug molecules, as there is currently no vaccine or treatment approved against COVID-19. | 2020-05-27 |
| 32395672 | As the COVID-19 pandemic spreads around the globe, access to radiation therapy remains critical for cancer patients. […] The priority for all radiation oncology departments is to protect the staff and to maintain operations in providing access to those patients requiring radiation therapy services. […] Patients with tumors of the aerodigestive tract and pelvis amongst others often experience toxicity during treatment, and there is a baseline risk that adverse effects may require hospital-based management. […] Routine care during weekly visits is important to guide patients through treatment and to mitigate against the need for hospitalization. […] Recognizing the need to provide access to treatment and the anticipated toxicity of such treatment, we have developed and implemented guidelines for clinical care management with the hope of avoiding added risk to our patients. | 2020-05-15 |
| 32395850 | The Australian Treatment Outcomes Profile (ATOP) is a brief clinical tool measuring recent substance use, health and wellbeing among clients attending alcohol and other drug (AOD) treatment services. […] We recruited a sample of 107 AOD clients across public sector specialist AOD treatment services in New South Wales, Australia between 2016 and 2018. […] Among 107 participants, 59% were attending for alcohol treatment and 41% for opioid treatment. | 2020-05-12 |
| 32396134 | Patients established on denosumab and teriparatide should continue planned therapy. | 2020-05-12 |
| 32396143 | Therefore, it is best to be regularly assessed these markers during treatment of COVID-19 patients. | 2020-05-12 |
| 32396163 | Early identification of patients with novel corona virus disease 2019 (COVID-19) who may develop critical illness is of great importance and may aid in delivering proper treatment and optimizing use of resources. | 2020-05-20 |
| 32396382 | News and social media platforms have implicated dietary supplements in the treatment and prevention of coronavirus disease 2019 (COVID-19). […] Rather, reference to evidence-based guidelines should guide treatment decisions. | 2020-05-12 |
| 32396397 | Case histories describe the remote initiation of insulin pump therapy and automated insulin delivery in T1D pregnancy. Results: Initial feedback suggests that video consultations are well received and that the patient experiences for women requiring face-to-face visits are greatly improved. | 2020-05-19 |
| 32396445 | Data on demographics, comorbidities, COVID-19 symptoms and severity, consult reason, treatment, and personal protective equipment (PPE) use were collected and analyzed. […] Otolaryngologists play an indispensable role in the treatment of COVID-19 patients but, due to their work, are at high risk of exposure. | 2020-05-15 |
| 32396446 | Here we present considerations in regard to treatment with quinine-derived drugs and the influence of masks on communication. | 2020-05-12 |
| 32396455 | The COVID-19 outbreak poses continued struggles due to the unprecedented number of patients admitted to intensive care units and the overwhelming need for mechanical ventilation. | 2020-05-12 |
| 32396601 | To provide a comprehensive summary of the implications of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and coronavirus disease 2019 (COVID-19) on orthodontic treatment, contingency management, and provision of emergency orthodontic treatment, using currently available data and literature. […] During the spread of the COVID-19 pandemic, elective orthodontic treatment should be suspended and resumed only when permitted by federal, provincial, and local health regulatory authorities. […] Emergency orthodontic treatment can be provided by following a contingency plan founded on effective communication and triage. […] Treatment advice should be delivered remotely first when possible, and where necessary, in-person treatment can be performed in a well-prepared operatory following the necessary precautions and infection prevention and control (IPAC) protocol. | 2020-05-12 |
| 32396683 | Stroke care in India has evolved rapidly in the last decade with a focus on stroke awareness, prevention, rapid triage, treatment, and rehabilitation. […] There is a need for public health systems in both developed and developing countries to improve awareness, implement proper strategies of triage, acute treatment, well-defined rehabilitation plans, telemedicine services, and virtual check-ins. | 2020-05-12 |
| 32396771 | Remdesivir has been recently a strong candidate for the treatment of Covid-19. […] Therefore, future disposal of agents such as remdesivir might be crucial for ensuring an efficient treatment, decrease mortality and allow early discharge.Communicated by Ramaswamy H. | 2020-05-30 |
| 32396773 | Furthermore, prediction of tACE2 soluble expression in E. coli makes it a suitable candidate to be targeted for Covid-19 therapeutics. | 2020-05-30 |
| 32396903 | Presently, the incidence of VTE is estimated at around 25% of patients hospitalized in the intensive care unit for COVID-19 even under anticoagulant treatment at prophylactic doses. […] In this review, we discuss present knowledge of the topic, the unique challenges of diagnosis and treatment of VTE, as well as some of the potential mechanisms of increased risk for VTE during the illness. […] Understanding the true impact of VTE on patients with COVID-19 will potentially improve our ability to reach a timely diagnosis and initiate proper treatment, mitigating the risk for this susceptible population during a complicated disease. | 2020-05-12 |
| 32396985 | Children/young adults seem to have a less severe clinical manifestation of COVID-19 (2), but data on disease susceptibility in pediatric transplant recipients on chronic immunosuppressive therapy are limited (3, 4). […] This poses major uncertainties regarding pediatric transplant activity and management of anti-rejection therapy. | 2020-05-12 |
| 32396996 | There is a pressing need to improve our understanding of the immunology of this disease to contain the pandemic by developing vaccines and medicines for the prevention and treatment of patients. | 2020-05-12 |
| 32397000 | Accordingly, such measures have led to concerns over how to maintain access to haemophilia treatment products and to the specialized integrated care medical follow up within the haemophilia treatment centers (HTCs). | 2020-05-12 |
| 32397174 | Indeed, treatment of CRS involves the use of both antivirals to control the underlying infection and immunosuppressive agents to dampen the aberrant pro-inflammatory response of the host. […] Autoimmune patients receiving immunosuppressants could be prone to SARS-CoV-2 infections; however, suspension of the ongoing therapy is contraindicated to avoid disease flares and a consequent increase in the infection risk. | 2020-05-14 |
| 32397399 | Objective: This study aimed to assess the role of Tocilizumab therapy (TCZ) in terms of ICU admission and mortality rate of critically ill patients with severe COVID-19 pneumonia. Design: Patients with COVID-19 pneumonia were prospectively enrolled in SMAtteo COvid19 REgistry (SMACORE). […] This study found that treatment with TCZ did not significantly affect ICU admission (OR 0.11; 95% CI between 0.00 and 3.38; p = 0.22) or 7-day mortality rate (OR 0.78; 95% CI between 0.06 and 9.34; p = 0.84) when compared with SOC. […] Analysis of laboratory measures showed significant interactions between time and treatment regarding C-Reactive Protein (CRP), alanine aminotransferase (ALT), platelets and international normalized ratio (INR) levels. […] Variation in lymphocytes count was observed over time, irrespective of treatment. Conclusions: TCZ administration did not reduce ICU admission or mortality rate in a cohort of 21 patients. | 2020-05-13 |
| 32397684 | The current pandemic coronavirus, SARS-CoV-2, is a global health emergency because of its highly contagious nature, the great number of patients requiring intensive care therapy, and the high fatality rate. […] In the absence of specific antiviral drugs, passive prophylaxis, or a vaccine, the treatment aim in these patients is to prevent the potent virus-induced inflammatory stimuli from leading to the acute respiratory distress syndrome (ARDS), which has a severe prognosis. | 2020-05-14 |
| 32397688 | Moreover, we provide an extensive list of resources that will help the scientific community access numerous types of databases related to SARS-CoV-2 OMICs and approaches to therapeutics related to COVID-19 treatment. | 2020-05-19 |
| 32397940 | The lack of targeted therapeutics and limited treatment options have triggered the scientific community to develop new vaccines or small molecule therapeutics against various targets of SARS-CoV-2. | 2020-05-30 |
| 32398164 | Drug repurposing/repositioning, a strategy effectively employed in cancer treatment, can represent a valid alternative. […] Most drugs considered for repurposing/repositioning in the therapy of the COVID-19 outbreak are commercially available and their dosage and toxicity in humans is well known, due to years (or even decades) of clinical use. […] Several drugs being re-considered for COVID-19 therapy are or have been used in cancer therapy. […] We present here a comprehensive analysis of available information on potential candidate cancer drugs that can be repurposed for the treatment of COIVD-19. | 2020-05-14 |
| 32398243 | It is currently unknown whether PD-1 blockade therapy impacts severity of illness from COVID-19 in patients with cancer. | 2020-05-13 |
| 32398268 | The patient’s condition improved after adjustment of therapy at home. […] We emphasise the utility and the opportunity that LUS presents in some clinical scenarios, like this COVID-19 pandemic, and how it may serve as a monitoring and therapy guide. | 2020-05-13 |
| 32398343 | While novel drugs are being developed, azithromycin has been identified as a candidate treatment in the interim. […] In vivo and in vitro studies were included assessing the safety and effectiveness of azithromycin for treatment of COVID-19, and/or the activity of azithromycin against SARS-CoV-2. […] There is no evidence to support the use of azithromycin for the treatment of COVID-19 outside of the context of clinical trials, unless it is used to treat bacterial super-infection. | 2020-05-13 |
| 32398383 | We provide the rationale for launching medical activities and indicate optimal practices until the consolidation of SARS COV-2 prevention and treatment methods. | 2020-05-14 |
| 32398569 | Children rarely needed admission to intensive care units (3%), and to date, only a small number of deaths have been reported in children globally. | 2020-05-18 |
| 32398607 | Combination therapy is well established in hypertension. […] Many guidelines recommend dual antihypertensive therapy as the initial treatment step as this results in faster blood pressure control, albeit with limited evidence of improved outcomes. […] Control of CVD risk factors through multiclass combination therapy (the polypill) was proposed many years ago. | 2020-05-13 |
| 32398876 | Serological assays are of critical importance to help define previous exposure to SARS-CoV-2 in populations, identify highly reactive human donors for convalescent plasma therapy and investigate correlates of protection. | 2020-05-13 |
| 32398901 | The limited biomedical and epidemiological understanding of COVID-19 along with the lack of vaccines and therapeutics have led to the reception of draconian measures from the societal safety domain, limiting human interaction through social distancing. | 2020-05-28 |
| 32398902 | Self-treatment (without medication) was the most used method when having health problems (by 28.2% to 51% of participants), followed by visiting commune health centers (24%) and self-medication (20.3%). | 2020-05-16 |
| 32399449 | Anticoagulant treatment is associated with decreased mortality in severe COVID-19 pneumonia. | 2020-05-16 |
| 32399452 | COVID-19 can co-occur with other viral infections.Some of these co-infections have active treatments, while supportive treatment is the mainstay of treatment for others. | 2020-05-16 |
| 32399455 | There is no proven antiviral therapy for COVID-19 so far, but profound immunosuppression has recently been suggested as a treatment for COVID-19-associated CRS. […] We present a case of life-threatening CRS caused by COVID-19 infection with a favourable response to immunosuppressive therapy with tocilizumab (TCZ). […] The rapid clinical and biochemical improvement following TCZ administration suggests that treatment with immunotherapy can be life-saving in selected patients with COVID-19-induced CRS. […] Cytokine release syndrome may cause sudden and potentially life-threatening clinical deterioration in COVID-19 pneumonia, particularly in younger patients.Immunosuppressive therapy may provide important additional therapeutic benefit in these patients.Tocilizumab, a specific IL-6 inhibitor, led to dramatic clinical improvement in a young patient with severe COVID-19-associated cytokine release syndrome. | 2020-05-16 |
| 32399457 | These thrombotic events include stroke, venous thromboembolism, pulmonary embolism and cardiac complications.Clinicians should carefully consider the risk of thrombosis in patients positive for COVID-19, including prophylaxis and treatment beyond discharge. | 2020-05-16 |
| 32399481 | The preferred imaging modality is chest computed tomography (CT) which plays an important role in early diagnosis, quarantine, and treatment as well as in the evaluation of therapeutic efficacy. | 2020-05-13 |
| 32399620 | Median chest CT scores peaked at 4 days after the beginning of treatment and then declined. | 2020-05-16 |
| 32399719 | CNS symptoms could be a potential indicator of poor prognosis; therefore, the prevention and treatment of CNS symptoms are also crucial for the recovery of COVID-19 patients. | 2020-05-29 |
| 32399806 | Hematologic consequences of this new infection allowed medical community to start new treatment approaches concerning infection going from targeted anti-inflammatory drugs to anticoagulation or stem cell therapies. […] A better understanding of Covid-19 pathophysiology, in particular hematological disorders, will help to choose appropriate treatment strategies. | 2020-05-16 |
| 32399942 | The allocation of hospital beds and ventilators, personal protective equipment, investigational therapeutics, and other scarce resources has required difficult decisions. | 2020-05-16 |
| 32399995 | To date, no study attempted to quantify the impact of the Covid-19 outbreak on incidence and treatment of acute stroke. | 2020-05-13 |
| 32400049 | The rapid diffusion of the SARS-CoV-2 together with the need for isolation for infected patients might be responsible for a suboptimal treatment for SARS-CoV-2 ACS patients. | 2020-05-13 |
| 32400074 | The first patient always maintained excellent oxygen saturation throughout hospitalization with no need for additional oxygen therapy. | 2020-05-13 |
| 32400084 | Both patients were on triple immunosuppressive therapy and had no signs of allograft dysfunction. […] Immunosuppressive therapy was unchanged and no experimental treatment was initiated. | 2020-05-13 |
| 32400380 | This review aims to elucidate potential mechanisms, which make HCQ treatment interesting in the fight against SARS-CoV-2 infection, as well as the current evidence for clinical use of HCQ to treat COVID-19. | 2020-05-18 |
| 32400911 | Cognitive processing therapy (CPT) is a trauma-focused, evidence-based treatment for posttraumatic stress disorder that is effective when delivered in-person or via telehealth. […] Given current limitations on the provision of in-person mental health treatment during the COVID-19 pandemic, this article presents guidelines and treatment considerations when implementing CPT via telehealth. […] Based on lessons learned from prior studies and clinical delivery of CPT via telehealth, recommendations are made with regard to overall strategies for adapting CPT to a telehealth format, including how to conduct routine assessments and ensure treatment fidelity. | 2020-05-13 |
| 32400924 | The COVID-19 pandemic is one of the most serious global challenges to delivering affordable and equitable treatment to children with cancer we have witnessed in the last few decades. […] We provide some practical advice for adapting diagnostic and treatment protocols for children with cancer during the pandemic, the measures taken to contain it (e.g., extreme social distancing), and how to prepare for the anticipated recovery period. | 2020-05-29 |
| 32400965 | These drugs may be used tentatively for general population with COVID-19, but for solid organ transplant (SOT) recipients with long-term immunosuppressive therapy and drug-related metabolic diseases, antiviral drugs should be chosen with particular care. | 2020-05-13 |
| 32401064 | The current outbreak of pneumonia caused by 2019 novel coronavirus (COVID-19) illustrated difficulties in lack of effective drugs for treatment. […] Accurate and rapid diagnostic tools are essential for early recognition and treatment of infectious diseases, allowing timely implementation of infection control, improved clinical care and other public health measures to stop the spread of the disease. | 2020-05-26 |
| 32401359 | One patient with prior HIV-infection continued anti-HIV treatment when diagnosed with COVID-19. […] The other patient was newly diagnosed with HIV-infection when diagnosed with COVID-19 and had not begun anti-HIV treatment. […] Both patients were treated with anti-viral, antibiotics, oxygen treatment and supportive care and recovered from severe pneumonia. | 2020-05-13 |
| 32401360 | Patients with cancer may have compromised immunity due to their malignancy and/or treatment, and may be at elevated risk of severe COVID-19. […] During the COVID-19 pandemic: In patients with cancer with fever and/or respiratory symptoms, consider causes in addition to COVID-19, including other infections and therapy-related pneumonitis. […] For suspected or confirmed COVID-19, discuss temporary cessation of cancer therapy with a relevant specialist. […] Communicate treatment modifications, and review once health service capacity allows. […] Discuss and document goals of care, and involve palliative care services in contingency planning. […] Australasian Leukaemia and Lymphoma Group; Australasian Lung Cancer Trials Group; Australian and New Zealand Children’s Haematology/Oncology Group; Australia and New Zealand Society of Palliative Medicine; Australasian Society for Infectious Diseases; Bone Marrow Transplantation Society of Australia and New Zealand; Cancer Council Australia; Cancer Nurses Society of Australia; Cancer Society of New Zealand; Clinical Oncology Society of Australia; Haematology Society of Australia and New Zealand; National Centre for Infections in Cancer; New Zealand Cancer Control Agency; New Zealand Society for Oncology; and Palliative Care Australia. | 2020-05-31 |
| 32401361 | 3 People’s Hospital of Jianghan University for a second treatment in March 2020. | 2020-05-13 |
| 32401373 | Covid-19 currently has no known treatment or a vaccine. | 2020-05-13 |
| 32401405 | The antimalarial drug hydroxychloroquine (HCQ) has long been used as a disease-modifying antirheumatic drug for the treatment of several inflammatory rheumatic diseases. | 2020-05-13 |
| 32401442 | The actual consensus is to continue the treatment with RAAS inhibitors, abrupt withdrawal, especially in patients with cardiac or renal conditions, being hazardous in terms of cardiovascular outcomes, except in patients hospitalized in intensive care with hemodynamic instability. | 2020-05-18 |
| 32401611 | The designed strategy represents a potential treatment to reduce the overall viral load in the lungs and to help the immune system to successfully stave off the infection. | 2020-05-20 |
| 32401686 | In the context of broad principles, issues including risks of treatment, principles of prioritizing resources, treatment of elderly patients, and psychosocial impact are discussed. […] Detailed treatment advice and options are given at a tumor stream level. […] We must maintain care for patients with cancer as best we can and recognize that COVID-19 poses a significant competing risk for death that changes conventional treatment paradigms. | 2020-05-13 |
| 32401715 | Effective antiviral therapy is important for tackling the coronavirus disease 2019 (COVID-19) pandemic. […] The median number of days from symptom onset to start of study treatment was 5 days (IQR 3-7). […] The combination group had a significantly shorter median time from start of study treatment to negative nasopharyngeal swab (7 days [IQR 5-11]) than the control group (12 days [8-15]; hazard ratio 4·37 [95% CI 1·86-10·24], p=0·0010). […] Early triple antiviral therapy was safe and superior to lopinavir-ritonavir alone in alleviating symptoms and shortening the duration of viral shedding and hospital stay in patients with mild to moderate COVID-19. […] Future clinical study of a double antiviral therapy with interferon beta-1b as a backbone is warranted. | 2020-05-31 |
| 32401931 | Besides, we briefly describe promising treatment strategies recognized until this moment. […] Currently, there is no effective treatment and fast diagnosis is still a challenge. | 2020-05-19 |
| 32402056 | To describe the characteristics, treatment, and outcomes of recipients of HT with COVID-19. […] Secondary measures included patient characteristics, laboratory analyses, changes to immunosuppression, and treatment administered for COVID-19. […] Twenty-two participants (79%) were admitted for treatment, and 7 (25%) required mechanical ventilation. […] Treatment of COVID-19 included hydroxychloroquine (18 patients [78%]), high-dose corticosteroids (8 patients [47%]), and interleukin 6 receptor antagonists (6 patients [26%]). | 2020-05-20 |
| 32402088 | Finally, we discuss measures to implement augmented care in care homes, including treatment with oxygen and subcutaneous fluids, and the frameworks which will be required if these are to be sustainable. | 2020-05-29 |
| 32402090 | Further research is needed focusing on the effect of existing liver-related comorbidities on treatment and outcome of COVID-19. | 2020-05-13 |
| 32402130 | Remdesivir has emerged as a promising treatment for SARS-Co-V-2 infection yet published clinical pharmacology and drug interaction studies are limited. | 2020-05-13 |
| 32402532 | In this context, the allocation of resources or the prioritization of treatment become crucial elements, and it is important to have an ethical reference framework to be able to make the necessary clinical decisions. […] For this, a process of narrative review of the evidence has been carried out, followed by a unsystematic consensus of experts, which has resulted in both the publication of a position paper and recommendations from SEMICYUC itself, and the consensus between 18 scientific societies and 5 institutes/chairs of bioethics and palliative care of a framework document of reference for general ethical recommendations in this context of crisis. | 2020-05-16 |
| 32402766 | What is urgently needed is an efficient pharmacological treatment for the treatment of severe cases. […] Theoretically, CQ and HCQ could thus be effectively used in the treatment of SARS-CoV pneumonia. […] From a pharmacological standpoint, however, the major problems of oral treatment with these drugs are possible severe side effects and toxicity. […] Empirical data on self-medication with a one-week aerosol application by two of the authors is presented. | 2020-05-26 |
| 32402856 | Despite previous outbreaks of SARS-CoV and the related MERS-CoV in recent years, neither a vaccine nor any other medication for an effective treatment are currently available. […] Endo-lysosomal two-pore cation channels have now emerged as potential novel targets for SARS-CoV treatment. | 2020-05-19 |
| 32403153 | The patient complained of prolonged fever and coughs for 7 days which had not improved after oral treatment with sultamicillin for 5 days, prescribed by the patient’s general practitioner. […] Suspecting a possible secondary bacterial infection at the beginning, intravenous antibiotic treatment with ampicillin/sulbactam was initiated. […] Due to clinical recovery antiviral therapy was not performed after confirming the diagnosis. | 2020-05-13 |
| 32403202 | Emergency rooms are inundated, and intensive care units are besieged with COVID-19 patients. | 2020-05-13 |
| 32403242 | With intensive care units operating at maximum capacity and such staggering mortality rates reported, it is imperative during this time-sensitive COVID-19 outbreak to identify patients with an increased risk of adverse outcomes and/or myocardial injury. | 2020-05-19 |
| 32403255 | The mechanism of liver injury is poorly understood and may result as a consequence of viral hepatitis, systemic inflammatory response, gut barrier and microbiome alterations, intensive care treatment or drug toxicity. | 2020-05-14 |
| 32403895 | Although the prevention and treatment of COVID 19 has become the priority for the majority of the population, most medical professionals are facing the challenge of balancing the management of this pandemic and treating patients with other diseases. | 2020-05-14 |
| 32403946 | Outcome from the infection were compared with infected noncancer patients. Results: Twenty patients (80%) were treated with antiviral therapy and hydroxychloroquine and five (20%) received hydroxychloroquine alone. | 2020-05-16 |
| 32403995 | Most recently SARS-CoV-2 virus (causing COVID-19) has led to a pandemic with no successful therapeutics. | 2020-05-22 |
| 32404126 | This study aims to assess the effectiveness of delivering Solution Focused Brief Therapy (SFBT) through telecommunication with a group of adolescents who present anxiety symptoms during the COVID-19 outbreak. […] We hypothesize that participants who are randomly assigned to receive 2-4 sessions of Solution Focused Brief Therapy would have better clinical outcomes than participants who are in the waitlist group. | 2020-05-15 |
| 32404189 | So far, there is no effective vaccine protection or proven therapy available against the SARS-CoV-2 virus. | 2020-05-15 |
| 32404205 | However, a subset of the chiropractic profession has claimed that spinal manipulative therapy (SMT) is clinically effective in improving one’s immunity, despite the lack of supporting scientific evidence. | 2020-05-16 |
| 32404219 | As in other European countries, the current Covid-19 pandemic has not only massively restricted normal life in Germany, it is also having a significant effect on medical treatment, particularly in the areas of child and adolescent psychiatric care, as well as on university teaching. | 2020-05-14 |
| 32404232 | Restrictions on usual activities are likely to induce mental stress especially among those who are autistic leading to an escalation in challenging behaviours, risk of placement breakdown, and increased the use of psychotropic medication. | 2020-05-14 |
| 32404302 | The infection can be life threatening and require intensive care treatment. […] Modified diagnostic and treatment algorithms are proposed to adapt evidence-based protocols for this unprecedented challenge. | 2020-05-14 |
| 32404451 | No specific therapy is available and supportive care with rest, fluids, and antipyretics for children is the recommended approach. […] Antiviral and immunomodulatory treatment is not recommended at this time for otherwise healthy children, and corticosteroids should also not be used. | 2020-05-15 |
| 32404473 | Accurate diagnoses of cases is key in managing the pandemic by identification, isolation and treatment of patients and defining the epidemiology of the virus. | 2020-05-14 |
| 32404477 | Our results highlight the promise of antibody-based therapeutics and provide a structural basis for rational vaccine design. | 2020-05-22 |
| 32404514 | Here, we highlight (i) the lessons that have been learnt so far and how they will benefit reducing the impact of COVID-19 disease and (ii) an update on the status of drug treatment and vaccine development to prevent COVID-19 and potential future related pandemics. […] Drugs are urgently needed for both prophylaxis and the treatment of severely ill patients; however, no proven effective therapies for SARS-CoV-2 currently exist. […] A number of drugs that have been approved for other diseases are being tested for the treatment of COVID-19 patients, but there is an absence of data from appropriately designed clinical trials showing that these drugs, either alone or in combination, will prove effective. […] This review summarizes the lessons learnt so far from the COVID-19 pandemic, examines the evidence regarding the drugs that are being tested for the treatment of COVID19, and describes the progress made in efforts to develop an effective vaccine. | 2020-05-20 |
| 32404651 | : The COVID19 crisis has created many additional challenges for patients with opioid use disorder, including those seeking treatment with medications for OUD. […] Some of these challenges include closure of substance use treatment clinics, focus of emergency departments on COVID-19 patients, social distancing and shelter in place orders affecting mental health, bystander overdose rescue, threats to income and supply of substances for people who use drugs. | 2020-05-22 |
| 32404652 | : During the COVID-19 pandemic, many addiction treatment and harm reduction organizations have had to reduce their hours and services for people with substance use disorders, placing these individuals at increased risk of death. […] In order to address restricted treatment access during COVID-19, guidance from the Substance Abuse Mental Health Services Administration, the US Drug Enforcement Administration, and the US Department of Health and Human Services has allowed for use of audio-only telehealth encounters for buprenorphine induction without requiring an in-person evaluation or video interface. […] In this new regulatory environment, we established the Rhode Island Buprenorphine Hotline, a phone hotline which functions as a “tele-bridge” clinic where people with moderate to severe opioid use disorder can be linked with a DATA 2000 waivered provider who can provide an initial assessment and, if appropriate, prescribe buprenorphine for unobserved induction and linkage to outpatient treatment. […] In this correspondence we briefly share our experience developing this common sense approach to addressing the complex problem of access to treatment only now permissible due to regulatory changes during COVID-19. | 2020-05-22 |
| 32404780 | It is necessary to extend isolation time, increase the number of nucleic acid detections and conduct early symptomatic treatment for children with both COVID-19 and additional health problems. | 2020-05-14 |
| 32404786 | All 25 children with laboratory-confirmed 2019-nCoV infection by real-time reverse transcription-PCR (RNA-PCR) were admitted from the 4 designated treatment hospitals of 2019-nCoV in Chongqing from January 19 to March 12, 2020. […] There was no significant difference of RNA turning negative between the groups of interferon, interferon plus ribavirin and interferon plus lopinavir or ritonavir treatment. | 2020-05-14 |
| 32404975 | This pandemic poses unprecedented stress on the health care system including programs performing allogeneic and autologous hematopoietic cell transplantation (HCT) and cellular therapy such as with CAR T cells. | 2020-05-16 |
| 32405058 | The current COVID-19 pandemic challenges oncologists to profoundly re-organize oncological care in order to dramatically reduce hospital visits and admissions and therapy-induced immune-related complications without compromising cancer outcomes. | 2020-05-18 |
| 32405071 | Eligible patients using renin-angiotensin system blockers (ACEI/ARBs) with a confirmed diagnosis of COVID-19 will be randomized to a strategy of continued ACEI/ARB treatment versus temporary discontinuation for 30 days. […] BRACE CORONA will evaluate whether the strategy of continued ACEI/ARB therapy compared with temporary discontinuation of these drugs impacts clinical outcomes among patients with COVID-19. | 2020-05-16 |
| 32405079 | Novel coronavirus infectious disease (COVID-19) has been spreading worldwide, and tracking laboratory indexes during the diagnosis and treatment of patients with severe COVID-19 can provide a reference for patients in other countries and regions. […] We closely tracked the epidemiological history, diagnosis and treatment process, as well as dynamic changes in routine blood indicators, of a severe COVID-19 patient who was hospitalized for 26 days. […] Dynamic changes in routine blood parameters might be helpful for the prognosis of COVID-19 patients and evaluation of the treatment effect. | 2020-05-31 |
| 32405080 | Monitoring T cell changes has important implications for the diagnosis and treatment of severe patients who may become critically ill. | 2020-05-31 |
| 32405088 | Guideline directed drug therapy including ACEI/ARB/ARNI is to be continued in patients with pre-existing HF. | 2020-05-16 |
| 32405101 | In this prospective study consecutive patients hospitalized in non-intensive care units with diagnosis of COVID-19 pneumonia and D-dimer > 1000 ng/ml were screened for asymptomatic DVT with complete compression doppler ultrasound (CCUS). | 2020-05-29 |
| 32405115 | The COVID-19 pandemic has brought major challenges to healthcare systems and public health policies globally, as it requires novel treatment and prevention strategies to adapt for the impact of the pandemic. […] Moreover, social and economic changes caused by the pandemic, along with the traditional difficulties regarding treatment access and adherence - will certainly worsen during this period, therefore aggravate their condition. […] In that sense, specific strategies for prevention and treatment must be discussed. health care professionals dealing with SUD must be aware of the risks and challenges they will meet during and after the COVID-19 outbreak. | 2020-05-22 |
| 32405117 | SARS-CoV-2-caused COVID-19 cases are growing globally, calling for developing effective therapeutics to control the current pandemic. | 2020-05-23 |
| 32405152 | Compliance with highest level of personal protection and restriction of treatment to emergency cases is recommended during the outbreak. | 2020-05-14 |
| 32405156 | Hydroxychloroquine (CLQ-OH)/azithromycin (ATM) combination therapy is currently being tested for the treatment of COVID-19, with promising results. […] This molecular mechanism may explain the beneficial effects of CLQ-OH/ATM combination therapy in patients with COVID-19. | 2020-05-22 |
| 32405160 | Patients admitted before March 13th (n=23) were prescribed the standard therapy (hydroxychloroquine, lopinavir and ritonavir) and were considered controls. | 2020-05-16 |
| 32405164 | Yet, the World Health Organization officially announced that there is still at present no recommended anti-nCoV vaccine for subject at-risk, nor treatment for patients with suspected or confirmed nCoV, let alone 2019-nCov. […] It is therefore timely and critical to propose new possible and practical approaches for preventive interventions for subjects at-risk, and for treatment of patients afflicted with 2019-nCov-induced disease (Corona Virus Disease 2019; COVID-19) before the present situation explodes into a worldwide pandemic. | 2020-05-16 |
| 32405226 | It has been used for centuries for the treatment of fever and chills, and has been recently approved for the treatment of malaria due to its endoperoxidase properties. […] In this review, we aim to provide a comprehensive update of the current knowledge of the effects of artemisinins in relation to respiratory diseases to identify gaps that need to be filled in the course of repurposing artemisinins for the treatment of respiratory diseases. […] In addition, we postulate whether artemisinins can also be repurposed for the treatment of COVID-19 given its anti-viral and anti-inflammatory properties. | 2020-05-23 |
| 32405229 | The evaluation of the treatment of these comorbidities at baseline and during COVID-19 is scarce and the results are conflicting. […] The aim of this review article was to summarize the prevalence of hypertension and CVD in patients with COVID-19, their influence on the outcome and the effect of treatment of hypertension and CVD in COVID-19 patients. | 2020-05-23 |
| 32405236 | This is a discussion and comparison of the virus structures, transmission characteristics, clinical symptoms, diagnosis, pathological changes, treatment and prevention of the two kinds of viruses, CoVs and IAVs. | 2020-05-23 |
| 32405418 | None of the infected nurses were hospitalized and all of them preferred to be quarantine at home and receive the necessary care and treatment (Oseltamivir, Azithromycin and Kaletra. […] This study also reported that receiving the necessary care and treatment at home was a good experience for nurses that can be used in some cases. | 2020-05-14 |
| 32405421 | Repurposing broad-spectrum antivirals is an immediate treatment opportunity for 2019 coronavirus disease (COVID-19). […] Favipiravir is an antiviral previously indicated for influenza and Ebola, which has shown some promise in early trials for treatment of COVID-19. […] Favipiravir may be safe and tolerable in short-term use, but more evidence is needed to assess the longer-term effects of treatment. | 2020-05-16 |
| 32405422 | There were no teratogenic concerns, but the evidence base was very limited.Based on a weighted-mean cost of US $61/kg, a 14-day course of treatment with nitazoxanide 500 mg BD would cost $1.41. […] We estimate that it would be possible to manufacture nitazoxanide as generic for $1.41 for a 14-day treatment course at 500 mg BD, up to $4.08 at 1100 mg TDS. […] If efficacy against SARS-CoV-2 is demonstrated in clinical studies, nitazoxanide may represent a safe and affordable treatment in the ongoing pandemic. | 2020-05-16 |
| 32405423 | Costs of production ranged between $0.30 and $31 per treatment course (10-28 days). […] Estimations for the minimum production costs can strengthen price negotiations and help ensure affordable access to vital treatment for COVID-19 at low prices globally. | 2020-05-16 |
| 32405454 | The patient referred to treatment clinic for COVID-19 in Imam Reza hospital of Tabriz (Iran) after having flu-like symptoms. […] Lopinavir/ritonavir (200mg/50mg) two tablet tow times, Ribavirin 200mg every six hours, and Oseltamivir 75mg tow times were given for the treatment of COVID-19. […] The medications used for treatment of pneumonia were Meropenem, Ciprofloxacin, Vancomycin. | 2020-05-30 |
| 32405509 | We discuss the current knowledge gaps driven by questions around the quality and consistency of clinical trial results, patient selection, diagnostic methodologies, use of suppressive antibiotic therapy, and methods for adverse event reporting. […] We provide specific recommendations for future trial designs of FMT to provide improved quality of the clinical evidence to better inform treatment guidelines. | 2020-05-14 |
| 32405620 | Since the World has been facing the COVID-19 pandemic, special attention has been taken concerning cancer patients; related to their immunosuppression status, adding risk for more aggressive COVID-19 and mortality, but also concerns about the access and the quality of care in cancer therapy. […] In essence, they are immunosuppressed in different intensities during their treatment. […] Most of them are elderly and all of them require long-term therapy, with prolonged contact with the health care system, possibly including a stem cell transplant during the treatment. | 2020-05-16 |
| 32405622 | This potential utilization of DPP4 as a binding target for SARS-CoV-2 may offer novel insight into the viral pathogenesis and help the surveillance and therapeutics strategy for meeting the challenge of COVID-19. | 2020-05-29 |
| 32405641 | The infection can be life threatening and require intensive care treatment. […] Modified diagnostic and treatment algorithms are proposed to adapt evidence-based protocols for this unprecedented challenge. | 2020-05-20 |
| 32405780 | With the continuous spread of the new coronavirus pneumonia epidemic in even the world, prevention and treatment of the disease have become urgent tasks. […] In addition to being controlled through effective isolation, we need a rapid response from the healthcare and biotechnology industries to accelerate drug treatment research. […] By reviewing the currently available literature published at home and abroad, we summarize the current research progress of drug treatment during the epidemic period. […] At present, the drugs that can be used for treatment mainly include antiviral drugs, antimalarials, glucocorticoids, plasma therapy, biological agents, and traditional Chinese medicine. […] The effectiveness and safety of drug therapy need to be confirmed by more clinical studies. | 2020-05-19 |
| 32405783 | The management of mild disease is supportive, while very many immunomodulatory and antiviral therapies are being investigated for the treatment of severe disease. | 2020-05-16 |
| 32405877 | At present, anti-IL-6, antiviral therapy, convalescent plasma, hydroxychloroquine, and azithromycin among others are being investigated as potential treatments for COVID-19. […] As the disease etiology and precise therapeutic interventions are still not definitively defined, we wanted to review the roles that complement and the contact system may have in either the treatment or pathogenesis of the disease. | 2020-05-25 |
| 32405882 | During the current viral outbreak, physicians should not neglect the possibility of other diseases that represent neurological emergencies and require immediate recognition and treatment. | 2020-05-16 |
| 32405955 | Older patients with CA and those with immune-mediated ataxias on immunosuppressive medication are potentially at high risk of developing serious complications of the infection, although it is also possible that immunosuppressive agents may provide a defense against cytokine storm. […] As the disruption of social patterns and healthcare delivery in response to the crisis continues, interruption of rehabilitation, speech and language therapy, and face-to-face consultations threatens to have a negative impact on the course and well-being of CA patients. | 2020-05-16 |
| 32405974 | Currently, the number of severe cases worldwide has increased rapidly, but the experience in the treatment of infected patients is still limited. […] Given the lack of specific antiviral drugs, multi-organ function support treatment is important for patients with COVID-19. […] This paper provides a clinical reference and a new strategy for the optimal treatment of COVID-19 worldwide. | 2020-05-15 |
| 32406115 | And, although not all of the microbially relevant infrastructure will be within reach of schools, there is usually access to a market, local food store, wastewater treatment plant, farm, surface water body, etc., all of which can provide opportunities to explore microbiology in action. | 2020-05-16 |
| 32406317 | It is noteworthy that Viomycin showed higher -CDocker energy as compared to the drugs currently under clinical trial for SARS-CoV-2 treatment viz. Ritonavir and Lopinavir. | 2020-05-25 |
| 32406348 | Introducing a mindfulness and meditation practice during this pandemic has the potential to complement treatment and is a low cost beneficial method of providing support with anxiety for all. | 2020-05-14 |
| 32406369 | It is extremely important to understand this phenomenon, as individuals with intermittent virus shedding could be falsely identified as reinfected and may benefit from ongoing antiviral treatment. | 2020-05-14 |
| 32406381 | The timely and accurate diagnosis of infection with severe acute respiratory syndrome (SARS) coronavirus 2 (SARS-CoV-2), the cause of coronavirus disease 2019 (COVID-19), remains the cornerstone of efforts to provide appropriated treatment for patients, to limit further spread of the virus and ultimately to eliminate the virus from the human society. […] We focus this article on (a) developments for improvement of diagnosis of specific SARS-CoV-2 virus, (b) laboratory changes in the immunologic and coagulation system, (c) therapeutic options for anticoagulant treatment of seriously affected patients and (d) on the perspectives through improvement of diagnostic and therapeutic medical procedures. | 2020-05-14 |
| 32406395 | As there is no vaccination and proper medicine for treatment, the recent pandemic caused by COVID-19 has drawn attention to the strategies of quarantine and other governmental measures, like lockdown, media coverage on social isolation, and improvement of public hygiene, etc to control the disease. | 2020-05-16 |
| 32406512 | Patients on these medications should not stop their medication prophylactically. | 2020-05-29 |
| 32406687 | Currently, the new coronavirus disease 2019 (COVID-19) is a global pandemic without any well-calibrated treatment. | 2020-05-23 |
| 32406853 | An important group who will be confronted with the treatment of COVID19 positive patients are HCP during (semi) acute surgery. | 2020-05-14 |
| 32406873 | In December 2019, in the city of Wuhan, in the Hubei province of China, treatment-resistant cases of pneumonia emerged and spread rapidly for reasons unknown. | 2020-05-19 |
| 32406927 | Convalescent plasma and hyperimmune immunoglobulin may reduce mortality in patients with respiratory virus diseases, and are currently being investigated in trials as a potential therapy for coronavirus disease 2019 (COVID-19). […] OBJECTIVES: To assess whether convalescent plasma or hyperimmune immunoglobulin transfusion is effective and safe in the treatment of people with COVID-19. […] Effectiveness of convalescent plasma for people with COVID-19 The following reported outcomes could all be related to the underlying natural history of the disease or other concomitant treatment, rather than convalescent plasma. […] We do not know whether convalescent plasma therapy affects mortality (very low-certainty evidence). […] Time to discharge from hospital Six studies reported time to discharge from hospital for at least some participants, which ranged from four to 35 days after convalescent plasma therapy. […] We are very uncertain whether or not convalescent plasma therapy affects the risk of moderate to severe adverse events (very low-certainty evidence). […] We are very uncertain whether or not convalescent plasma therapy affects the risk of serious adverse events (very low-certainty evidence). […] We identified very low-certainty evidence on the effectiveness and safety of convalescent plasma therapy for people with COVID-19; all studies were at high risk of bias and reporting quality was low. | 2020-05-19 |
| 32406985 | Herein, we report a case of successful treatment of SARS-CoV-2 induced inflammatory syndrome by utilization of the interleukin-6 receptor antagonist (IL-6Ra) tocilizumab. | 2020-05-14 |
| 32407051 | However, the efficacy of hyper-immune/convalescent plasma treatment for severe infectious diseases is still controversial. […] The optimal dose and time point, as well as the clinical benefit of hyper- immune/convalescent plasma therapy, needs further investigation in larger well-controlled trials. | 2020-05-14 |
| 32407142 | Bad advice can lead to tragedy, such as death from taking an unproven medication.1 Now, more than ever, public health policies should be based on the best available evidence. | 2020-05-14 |
| 32407178 | The challenge of social distancing, providing care for those infected by COVID-19, continuing appropriate treatment of time-sensitive diseases, and the looming threat of health care worker infections required swift planning and restructuring of training programs. | 2020-05-14 |
| 32407289 | It is also recommended to increase and expand resources of intensive care units including respirators, increase the capacity and the number of trained health staff in the area of public health and epidemiology, ensure continued provision of essential public health programs and mobilize the resources of non-governmental sector and donors to provide services for refugees and vulnerable populations. | 2020-05-14 |
| 32407459 | We conducted a systematic review and meta-analysis of all published studies up to March 15, 2020 which reported COVID-19 clinical features and/or treatment outcomes. 45 studies reporting 4203 patients were included. […] Treatment with lopinavir-ritonavir showed no significant benefit in mortality and ARDS rates. | 2020-05-29 |
| 32407539 | Many small stand-alone trials and observational studies of single-agent interventions are currently running or in planning; many of these will likely not deliver robust results that could support regulatory and patient-level treatment decisions. […] We here discuss actions that all stakeholders in the clinical trial ecosystem need to take to ensure that the window of opportunity during this pandemic will not shut, both for patients in need of treatment and for researchers to conduct decision-relevant clinical trials. | 2020-05-14 |
| 32407543 | COVID-19 pandemic is an emerging new human disease, where no vaccines, or monoclonal antibodies (mAbs), or drugs are currently available for therapy. | 2020-05-14 |
| 32407609 | The patient with older age and higher comorbidities failed to recover from the viral illness that has no definitive treatment. | 2020-05-14 |
| 32407719 | One patient died after withdrawal of life-sustaining therapy because of metastatic cancer. | 2020-05-30 |
| 32407772 | Transparent and clear communication is crucial, coupled with dedication to provide the best possible care to patients, including palliative care. | 2020-05-16 |
| 32407884 | There is no known effective therapy for patients with COVID-19. […] We reviewed ECG tracings from baseline and until 3 days after completion of therapy to determine the progression of QTc and incidence of arrhythmia and mortality. […] Seven patients required premature termination of therapy. […] This risk mandates careful consideration of HY/AZ therapy in lights of its unproven efficacy. | 2020-05-16 |
| 32407959 | SARS-CoV-2 is causing an increasing number of deaths worldwide because no effective treatment is currently available. […] Remdesivir has shown in vitro activity against coronaviruses and is a possible antiviral treatment for SARS-CoV-2 infection. | 2020-05-31 |
| 32408070 | Currently, drug repurposing is an alternative to novel drug development for the treatment of COVID-19 patients. | 2020-05-26 |
| 32408155 | Fingolimod is used for immune therapy in patients with multiple sclerosis. […] Long-term treatment is associated with a small increase in the risk of herpes virus reactivation and respiratory tract infections. […] Patients with coronavirus disease 2019 (COVID-19) under Fingolimod treatment have not been described. […] We report a 57-year old female patient with a relapsing remitting multiple sclerosis under fingolimod treatment who experienced a severe COVID-19 infection in March 2020 (Extended Disability Status Scale: 2.0). […] Having peripheral lymphopenia typical for fingolimod treatment (total lymphocytes 0.39/nL [reference range 1.22-3.56]), the patient developed bilateral interstitial pneumonia with multiple ground-glass opacities on chest CT. […] Fingolimod medication was stopped. | 2020-05-26 |
| 32408156 | These results will provide a helpful reference for diagnosis and clinical treatment of COVID-19 patients. | 2020-05-29 |
| 32408336 | However, treatment options and a cellular understanding of SARS-CoV-2 infection are lacking. […] Furthermore, our findings provide insight for the development of therapy options for COVID-19. | 2020-05-14 |
| 32408338 | A suitable small animal model is needed to support vaccine and therapy development. | 2020-05-14 |
| 32408391 | A recent paper by Tang et al. [2] in this journal reported that heparin treatment reduced mortality of COVID-19 patients with elevated D-dimer; similar preliminary results have been reported elsewhere [3]. | 2020-05-14 |
| 32408508 | COVID-19 patients management requires availability of sufficiently large number of Intensive Care Units (ICUs) beds. | 2020-05-19 |
| 32408730 | Patients receiving hemodialysis are more vulnerable to viral transmission because their immune functions are impaired and they receive treatment within a narrow space. […] Calling on previous experience with Middle East Respiratory Syndrome during the 2015 outbreak, the joint committee of the Korean Society of Nephrology and the Korean Society of Dialysis Therapy quickly formed a COVID-19 task force team to develop a manual before the first index case was diagnosed in the hemodialysis unit. […] The areas of infection control covered by these guidelines include standard precautions, performing dialysis therapy for confirmed or suspected cases, performing cohort isolation for contact patients, and disease monitoring and contact surveillance. | 2020-05-15 |
| 32408842 | Care for patients with cancer is particularly important given increased infection rates and worse outcomes from COVID-19 in this patient population, as well as potential adverse outcomes if treatment pathways need to be compromised. […] Specifically, we highlight challenges related to safe handling of hazardous drugs and maintaining high-quality medication safety standards that have impacted various stakeholders. | 2020-05-15 |
| 32409150 | Chloroquine or hydroxychloroquine (chloroquine) plus azithromycin is considered as therapy for COVID-19. […] We included autoimmune disease patients aged ≥18 years initiating azithromycin or amoxicillin for ≥5 days during chloroquine treatment. […] Covariates were adjusted using stabilized inverse probability treatment weighting. | 2020-05-18 |
| 32409298 | The COVID-19 pandemic has created major insecurities regarding whether we can and should maintain the current standards of diagnosis and treatment and access to care for patients with cancer. […] More than ever, it seems to be mandatory to adhere to evidence-based medicine and not to prescribe potentially toxic, notably immunsuppresssive systemic therapy where evidence for efficacy is low. | 2020-05-16 |
| 32409433 | Antivirals with evidence of clinical activity must be studied as treatment and prophylaxis for those at high risk for severe COVID-19. | 2020-05-16 |
| 32409434 | At this time, there is no clinical evidence to suggest that treatment with RAS inhibitors should be discontinued in stable patients with COVID-19. | 2020-05-28 |
| 32409436 | Treatment of COVID-19 for patients with underlying ILD or sarcoidosis may include hospital admission, possible drug treatment, caution with steroids, and avoidance of mechanical ventilation in acute exacerbation of ILD. | 2020-05-15 |
| 32409438 | At present, there are no firm guidelines for the treatment of COVID-19-related emotional distress. | 2020-05-28 |
| 32409439 | Anti-IL-6 drugs are being widely used experimentally and as off-label therapy for patients with COVID-19 who are sick and deteriorating but have a reasonable chance of recovering, but they are still unproven and unapproved for this use. | 2020-05-15 |
| 32409440 | Cardiac imaging should only be ordered if its benefits outweigh its risks, with anticipated changes in acute treatment and outcomes, and no suitable alternative of sufficient adequacy is available. | 2020-05-15 |
| 32409486 | Hydroxychloroquine at a dose of 600 mg/day within 48 hours of admission to hospital (treatment group) versus standard care without hydroxychloroquine (control group). […] Analyses were adjusted for confounding factors by inverse probability of treatment weighting. […] In the main analysis, 84 patients who received hydroxychloroquine within 48 hours of admission to hospital (treatment group) were compared with 89 patients who did not receive hydroxychloroquine (control group). […] In the weighted analyses, the survival rate without transfer to the intensive care unit at day 21 was 76% in the treatment group and 75% in the control group (weighted hazard ratio 0.9, 95% confidence interval 0.4 to 2.1). […] Overall survival at day 21 was 89% in the treatment group and 91% in the control group (1.2, 0.4 to 3.3). […] Survival without acute respiratory distress syndrome at day 21 was 69% in the treatment group compared with 74% in the control group (1.3, 0.7 to 2.6). […] At day 21, 82% of patients in the treatment group had been weaned from oxygen compared with 76% in the control group (weighted risk ratio 1.1, 95% confidence interval 0.9 to 1.3). […] Eight patients in the treatment group (10%) experienced electrocardiographic modifications that required discontinuation of treatment. […] Hydroxychloroquine has received worldwide attention as a potential treatment for covid-19 because of positive results from small studies. | 2020-05-19 |
| 32409501 | Patients in the intensive care unit requiring therapy for glycemic control should be handled solely by intravenous insulin using exact dosing with a perfusion device. | 2020-05-16 |
| 32409502 | Compared with normal weight patients, those who were overweight had 1.84-fold odds of developing severe COVID-19 (odds ratio [OR] 1.84, 95% CI 0.99-3.43, P = 0.05), while those who were obese were at 3.40-fold odds of developing severe disease (OR 3.40, 95% CI 1.40-2.86, P = 0.007), after adjusting for age, sex, epidemiological characteristics, days from disease onset to hospitalization, presence of hypertension, diabetes, cardiovascular disease, chronic obstructive pulmonary disease, liver disease and cancer, and drug used for treatment. […] As the severe acute respiratory syndrome coronavirus 2 may continue to spread worldwide, clinicians should pay close attention to obese patients, who should be carefully managed with prompt and aggressive treatment. | 2020-05-15 |
| 32409561 | Multicentre, open label, randomised controlled trial. 16 government designated covid-19 treatment centres in China, 11 to 29 February 2020. 150 patients admitted to hospital with laboratory confirmed covid-19 were included in the intention to treat analysis (75 patients assigned to hydroxychloroquine plus standard of care, 75 to standard of care alone). […] Hydroxychloroquine administrated at a loading dose of 1200 mg daily for three days followed by a maintenance dose of 800 mg daily (total treatment duration: two or three weeks for patients with mild to moderate or severe disease, respectively). | 2020-05-19 |
| 32409680 | Early identification of possible hyperinflammation could be fundamental and should guide decision making regarding hospitalization, early respiratory support, and therapy with immunosuppression to improve mortality. | 2020-05-16 |
| 32409832 | This Viewpoint summarizes the strong scientific arguments supporting the use of alisporivir, a non-immunosuppressive analogue of cyclosporine A with potent cyclophilin inhibition properties that has reached Phase 3 clinical development, for the treatment of COVID-19. | 2020-05-29 |
| 32410003 | Insights in pathophysiological mechanisms of less severity in children could be important for devising therapeutics for high-risk adults and elderly. | 2020-05-25 |
| 32410206 | The following data were obtained from electronic medical records: demographics, medical history, exposure history, underlying comorbidities, symptoms, signs, laboratory findings, computer tomography scans, and treatment measures. […] The outcome of treatment indicated that in patients with the common-type COVID-19, interferon-α2b, but not novaferon, had some benefits, antibiotics treatment was not needed, and corticosteroids should be used cautiously. […] We observed some treatment benefits with interferon-α2b and corticosteroid therapies but not with novaferon and antibiotic treatment in our study population. | 2020-05-25 |
| 32410245 | After treatment, two patients met the standard and were discharged. | 2020-05-15 |
| 32410319 | We also call for guidelines for management and treatment as well as research to understand the epidemiology of coinfection This article is protected by copyright. | 2020-05-15 |
| 32410413 | To identify predictors of pulmonary fibrosis development by combining follow-up thin-section CT findings and clinical features in patients discharged after treatment for COVID-19. […] 10.0 days, p = 0.001), pulsed steroid therapy (11.0 days vs. […] 5.0 days, p < 0.001), and antiviral therapy (12.0 days vs. | 2020-05-20 |
| 32410714 | Of all the studied patients, 85 (37.6%) received invasive mechanical ventilation, including 14 (6.2%) treated with extracorporeal membrane oxygenation (ECMO) at the same time, 20 (8.8%) received noninvasive mechanical ventilation, and 24 (10.6%) received continuous renal replacement therapy. | 2020-05-18 |
| 32410760 | The two groups differed in disease incidence (group 1 vs group 2, 0·3 vs ten per month), mean age (3·0 vs 7·5 years), cardiac involvement (two of 19 vs six of ten), KDSS (zero of 19 vs five of ten), MAS (zero of 19 vs five of ten), and need for adjunctive steroid treatment (three of 19 vs eight of ten; all p<0·01). | 2020-05-18 |
| 32410772 | Vaccines for this deadly virus are currently under development and many drugs used for other indications have been repurposed and investigated for prophylaxis and treatment of COVID 19. […] As per SOLIDARITY trial by WHO, some of the most promising candidates include chloroquine phosphate and hydroxychloroquine which are anti-malarial medications, Remdesivir, Lopinavir-Ritonavir combination with or without interferon which are anti-HIV drugs and convalescent plasma therapy. […] The situation is still evolving and hence there is yet no definitive therapy but to conclude the use of repurposed medications can be a boon till a definitive therapy and vaccines are developed. | 2020-05-26 |
| 32410912 | Brachytherapy is one of the important treatment modalities for some subsites of cancers. […] Brachytherapy provides an opportunity for the patients and the physicians during the COVID-19 outbreak; it can retain the patient’s chance for treatment while limiting the chance of exposure and transmission of infection. | 2020-05-16 |
| 32410913 | The aim of this article is to provide basic consolidated guidance and checklists to clinicians in the neonatal intensive care units in key aspects of preparation needed to counter exposure or infection with COVID-19. | 2020-05-18 |
| 32411313 | Here, we report on the treatment of eight severe COVID-19 pneumonia patients– seven hospitalized in intensive care units (ICUs) in Greece and one non-ICU patient in the Netherlands– with the interleukin-1 receptor antagonist Anakinra. […] At the end-of-treatment, ICU patients had less need for vasopressors, significantly improved respiratory function and lower HScore. | 2020-05-28 |
| 32411315 | Current emergency unit asthma guidelines recommend bronchodilators be administered by metered dose inhaler (MDI) and spacer for mild-moderate asthma and include it as a choice even in severe asthma, but many emergency units continue to prefer nebulised therapy for patients who urgently require beta-agonists. […] The utilization of nebulised therapy potentially increases the risk of aerosolization of the coronavirus. […] Since nosocomial transmission of respiratory pathogens is a major threat in the context of the SARS-CoV-2 pandemic, use of nebulised therapy is of even greater concern due to the potential increased risk of infection spread to nearby patients and health-care workers. […] We propose a risk stratification plan that aims to avoid nebulised therapy, when possible, by providing an algorithm to help better delineate those who require nebulised therapy. […] Furthermore, expedient treatment of patients with high dose MDI therapy augmented with more rapid initiation of systemic therapy may help ensure patients are less likely to deteriorate to the stage where nebulisers are required. | 2020-05-15 |
| 32411566 | Yet, they have also been utilized in the treatment of various pulmonary disorders with vasoconstriction. […] Patients treated with a CCB were significantly more likely to survive than those not treated with a CCB: 12 (50%) survived and 12 expired in the CCB group vs. six (14.6%) that survived and 35 (85.4%) that expired in the No-CCB treatment group (P<.01; p=0.0036). […] Only one patient (4.2%) was intubated in the CCB group whereas 16 (39.0%) were intubated in the No-CCB treatment group (P<.01; p=0.0026). […] Including either nifedipine or amlodipine in medication regimens for elderly patients with hypertension hospitalized for COVID-19 may be considered. | 2020-05-18 |
| 32411619 | The availability of pathogen-specific treatment options for respiratory tract infections (RTIs) increased the need for rapid diagnostic tests. […] In this review, we summarize recently published characteristics of POCTs and discuss their implications for the treatment of RTIs. | 2020-05-19 |
| 32411770 | Here, we attempt to describe the clinical characteristics and treatment experiences of discharged cases from Taizhou, China. […] All patients received combined antiviral treatment on admission, including β-interferon, lopinavir/tonavir, Abidol and oseltamivir. […] All patients with severe conditions received gamma globulin and hormone therapy. […] Early therapy and comprehensive therapy are key to the outcome for patients with COVID-19-infected pneumonia, especially for those with severe pneumonia. | 2020-05-18 |
| 32411941 | We propose several suggestions related to treatment of COVID-19 pneumonia with chloroquine/hydroxychloroquine that we think must be taken into consideration to fit the evolving situation of the pandemic in Greece. | 2020-05-16 |
| 32412159 | We performed a multicenter nationwide observational study within the Swiss Transplant Cohort Study (STCS) to describe the epidemiology, clinical presentation, treatment and outcomes of the first microbiologically documented SARS-CoV-2 infection among SOT recipients. | 2020-05-15 |
| 32412310 | Prostate cancer is one of the most common cancers among men and raises particular interest during the pandemic as recent reports show that the TMPRSS2 (and other serine proteases), which facilitate the entry, replication and budding of the virion from a cell, can be inhibited using androgen deprivation therapy. | 2020-05-15 |
| 32412509 | To date, there is no specific therapy for SARS-CoV-2 infection. | 2020-05-26 |
| 32412515 | Non-invasive mechanical ventilation and high-flow oxygen therapy are not recommended due to the generation of aerosol (associated with risk of viral spread among health personnel), and neither is extracorporeal membrane oxygenation or the use of steroids. […] So far, there is no specific antiviral treatment for patients with COVID-19, and neither are there results of controlled trials supporting the use of any. | 2020-05-15 |
| 32412811 | This descriptive investigation was undertaken at three oncology units to report queries, needs, and fears related to severe acute respiratory syndrome coronavirus 2 (COVID-19) of patients with cancer and to avoid uncontrolled treatment delays or withdrawal, behavioral mistakes, and panic. | 2020-05-22 |
| 32412891 | A number of pharmacologic regimens, including hydroxychloroquine-azithromycin, antiviral therapy (eg, remdesevir), and anti-IL-6 agents (e.g., toclizumab), have been highlighted by investigators over the course of the pandemic, based on the therapy’s potential to interrupt the viral life-cycle of SARS-CoV-2 or preventing cytokine storm. […] At present, there have been no conclusive series of reproducible randomised clinical trials demonstrating the efficacy of any one drug or therapy for COVID-19. […] COVID-19 positive patients (n=5) at a single institution received hyperbaric oxygen therapy (HBOT) between 13 and 20 April 2020. […] Larger studies are likely to define the role of HBOT in the treatment of this novel disease. | 2020-05-16 |
| 32412918 | The undistinguishable similarity of the genomic sequences of Severe Respiratory Syndrome (SARS)-CoV, Middle East Respiratory Syndrome (MERS)-CoV, and Bat SARS-CoV-bat-SL-CoVZC45 and bat-SL-CoVZXC21-to nCoV-2019 has facilitated the process of identifying primary treatment measures. | 2020-05-15 |
| 32412931 | In the setting of COVID-19, opioid use disorder treatment paradigms are being disrupted, including the fact that methadone clinics are scrambling to give “take-home” doses where they would typically not. […] The rapid transition away from in-person examination, dosing and group therapy in an era of social isolation calls for adjustments to clinical practice, including emphasizing patient-provider communication, favoring new inductees on buprenorphine and leveraging technology to optimize safety of medication treatment. | 2020-05-20 |
| 32413276 | The worldwide spread of COVID-19 highlights the need for an efficient approach to rapidly develop therapeutics and prophylactics against SARS-CoV-2. | 2020-05-18 |
| 32413300 | Therapeutics including antivirals, immunomodulators, and vaccines are in development. | 2020-05-19 |
| 32413527 | Information technologies, treatment prioritization and implementation of hypofractionation and protection procedures allowed balancing between cancer patient care and patient/healthcare workers safety. | 2020-05-31 |
| 32413554 | The COVID-19 pandemic has broadly disrupted biomedical treatment and research including non-invasive brain stimulation (NIBS). | 2020-05-29 |
| 32413608 | Therefore, this study investigated the impact of the current pandemic situation on HIV care and continuity of antiretroviral treatment (ART) supplies in CEE countries. | 2020-05-31 |
| 32413619 | Our findings demonstrate significant physicochemical differences between Lentinan extracts, which produce differential in vitro immunomodulatory and pulmonary cytoprotective effects that may also have positive relevance to candidate COVID-19 therapeutics targeting cytokine storm. | 2020-05-31 |
| 32413736 | Essential elements that process SARS-CoV2 cell entry and specific characteristics that allow SARS-CoV2 to escape the immune system have the potential as targets for COVID-19 therapy. | 2020-05-28 |
| 32414384 | By plotting the number of patients receiving treatment against day, it is clear that implementing “pairing assistance” is a turning point in China’s fight against epidemics. | 2020-05-20 |
| 32414390 | To regulate the emergency treatment of trauma patients during the outbreak, we drafted this paper from a trauma surgeon perspective according to practical experience in Wuhan. | 2020-05-20 |
| 32414626 | The coronavirus disease 2019 (COVID-19) pandemic is leading to delays in the treatment of many urologic cancers. […] To provide a contemporary picture of the risks from delayed treatment for urologic cancers to assist with triage. […] Treatment of most patients with intermediate- and high-risk PCa can be deferred 3-6 mo without change in outcomes. […] With radiotherapy, neoadjuvant androgen deprivation therapy (ADT) is the standard of care. […] Patients with metastatic renal cancer may consider vascular endothelial growth factor targeted therapy over immunotherapy. […] Risks for delay in the treatment of upper tract urothelial cancer depend on grade and stage. […] Expert guidance recommends expedient local treatment of testis cancer. […] The coronavirus disease 2019 pandemic has led to delays in the treatment of patients with urologic malignancies. […] Based on a review of the literature, patients with high-grade urothelial carcinoma, advanced kidney cancer, testicular cancer, and penile cancer should be prioritized for treatment during these challenging times. | 2020-05-19 |
| 32414757 | First, it is a firm principle of medical ethics that an effective treatment or vaccine should not be withheld from patients if their life may depend on it. | 2020-05-28 |
| 32414996 | The long incubation period, high infectious rate, varied manifestation, and absence of effective treatment make it difficult to manage the disease transmission. […] Every patient presenting for treatment should be treated as a potential asymptomatic infected case. […] Patients should be categorized based upon the priority as acute (require immediate treatment/surgery within 24 h), sub-acute (requiring treatment within a maximum of 7-10 days), or chronic (requiring treatment within a month). | 2020-05-20 |
| 32415305 | Consequently, specific adjustments for their treatment need to be made to cope with this situation. […] Therefore, it is of significance to summarize the relevant experience of China in the prevention and control of COVID-19 infection and treatment of patients with cancer during the epidemic. | 2020-05-29 |
| 32415348 | Senior otologic surgeons from six teaching hospitals from various countries affected by the COVID-19 from around the world met remotely to make recommendations on reorganizing schedules for the treatment of cholesteatoma which has a risk of severe morbidity and mortality. | 2020-05-19 |
| 32415419 | Hydroxychloroquine (HCQ) is an old medication for malaria. | 2020-05-19 |
| 32415426 | Growing concerns about anxiety associated with COVID-19 have led to recommendations for effective self-care, and greater availability of mental health treatment. | 2020-05-19 |
| 32415472 | To evaluate stereotactic body radiotherapy (SBRT) in low-risk Prostate Cancer patients as preferred treatment option in emergency health conditions. | 2020-05-19 |
| 32415494 | In view of the inconsistent and limited evidence and after weighing up the benefits and risks, we would not currently recommend discontinuing or switching an effective treatment with RAS blockers. | 2020-05-19 |
| 32415658 | The treatment of patients with rectal cancer requires both a multidisciplinary approach and a significant amount of resources. […] It is therefore imperative to rethink how rectal cancer treatment can be aligned with the current COVID-19 pandemic paradigms. | 2020-05-19 |
| 32415690 | Resurgence in the use of chloroquine as a putative treatment for COVID-19 has seen recent cases of fatal toxicity due to unintentional overdoses. | 2020-05-16 |
| 32415723 | This statement also provides recommendations where appropriate in assessing indications for therapy, reducing therapy-associated immunosuppression and reducing healthcare utilisation in patients with specific haematological malignancies during the COVID-19 pandemic. […] Specific decisions regarding therapy of haematological malignancies will need to be individualised, based on disease risk, risks of immunosuppression, rates of community transmission of COVID-19 and available local healthcare resources. | 2020-05-16 |
| 32415727 | We aimed to assess health literacy, disease knowledge, treatment dissatisfaction and biologics attitudes toward COVID-19. […] Despite only 8.1% thought that biologics may increase the risk of COVID-19, 18.4% and 21.4% of the patients were evaluating the possibility to discontinue or modify the dosage of the current biologic therapy, respectively. […] Patients with lower DLQI (P = .006), longer disease duration (P = .051) and lower scholarity (P = .007) have thought to discontinue/modify autonomously their biologic therapy. | 2020-05-28 |
| 32415767 | In this expert opinion, conceived by the task force involving the Working Groups on Valvular Heart Diseases and Cardiac Surgery as well as the Association of Cardiovascular Intervention of the Polish Cardiac Society, modification of diagnostic pathways, principles of healthcare personnel protection, and treatment guidelines regarding triage and prioritization are suggested. […] Heart Teams responsible for the treatment of valvular heart disease should continue their work using telemedicine and digital technology. […] The treatment of aortic stenosis and mitral regurgitation has to be offered particularly due to urgent indications and in patients with advanced disease and poor prognosis. […] Importantly, as soon as the local epidemic situation improves, efforts must be made to restore standard opportunities for elective treatment of valvular heart disease and occluder‑based therapies according to existing guidelines, thus rebuilding the state ‑of ‑the ‑art cardiovascular services. | 2020-05-29 |
| 32415882 | We provide recommendations for preoperative tests, indications for immediate care vs possible delayed treatment, and warnings relating to dural resection and intracranial dissection, given the potential neurotropism of SARS-CoV2 and practical suggestions for managing cancer care in a period of limited resources. […] We also postulate some thoughts on the promising role of telemedicine in multidisciplinary case discussions and posttreatment surveillance. | 2020-05-16 |
| 32415905 | Both cases were discharged following a treatment regimen including discontinued immunosuppressant and low-dose methylprednisolone-based therapy. […] There were no signs of rejection during the treatment. | 2020-05-16 |
| 32416116 | Of these, 14.3% required renal replacement therapy (RRT). | 2020-05-30 |
| 32416121 | Their demographic data, medical history, signs and symptoms of COVID-19, laboratory test results, and final outcomes of COVID-19 treatment were collected and analyzed. | 2020-05-31 |
| 32416259 | A promising target for both diagnosis and therapeutics treatments of the new disease named COVID-19 is the coronavirus (CoV) spike (S) glycoprotein. | 2020-05-31 |
| 32416289 | We included patients hospitalized at the University Hospital of Rome Tor Vergata, medical center dedicated to the treatment of patients with COVID-19 diagnosis, who underwent an anamnestic interview about sNS consisting of 13 items, each related to a specific symptom, requiring a dichotomized answer. | 2020-05-22 |
| 32416330 | Treatment decisions in patients with multiple sclerosis (MS) during the coronavirus disease 2019 (COVID-19) pandemic are challenging. […] Case report RESULTS: We report a fingolimod-treated MS patient who developed severe COVID-19 but recovered after treatment with tocilizumab. […] This report suggests that a brief course of tocilizumab for the treatment of severe COVID-19 may be effective while not aggravating pre-existing MS. | 2020-05-26 |
| 32416370 | Similar ‘symptoms alert-to-admission’ and ‘door-to-treatment’ times were observed. | 2020-05-29 |
| 32416415 | Mortality is principally due to severe Acute Respiratory Distress Syndrome (ARDS) which relays only on supportive treatment. […] These observations prompt to consider this cytotoxic therapy in HLH associated to moderately severe to severe forms of COVID-19. | 2020-05-26 |
| 32416527 | SMBG needs to be practiced on regular basis, especially among the patients with diabetes on insulin therapy. | 2020-05-27 |
| 32416535 | This proposed model is premised on transmission of SARS-CoV-2 from human feces through municipal waste water treatment plants into the natural aquatic environment where potential wildlife hosts become infected. | 2020-05-29 |
| 32416769 | Kidney involvement is frequent, with clinical presentation ranging from mild proteinuria to progressive acute kidney injury (AKI) necessitating renal replacement therapy (RRT). […] As no specific treatment options exist for AKI secondary to COVID-19, intensive care is largely supportive. | 2020-05-29 |
| 32416785 | RAAS inhibitors do not increase the risk of COVID-19 requiring admission to hospital, including fatal cases and those admitted to intensive care units, and should not be discontinued to prevent a severe case of COVID-19. | 2020-05-31 |
| 32417070 | Availability of personal protective equipment (PPE) and medication was better than alcohol (70% conc.). […] Government and policymakers strive to mitigate the shortage of PPE and medication. | 2020-05-20 |
| 32417123 | This targeted strategy consists of using fully recovered COVID 19 Heroes, that is, brave volunteers, as the source of antibodies in plasma collected by plasmapheresis or affinity column- derived antibodies, both are sterilised and pathogen inactivated for substitution therapy for use in those populations in need of antibody. | 2020-05-19 |
| 32417136 | A patient with severe CRSwNP, asthma, and NSAIDS received dupilumab treatment. […] Three weeks after therapy onset, the patient was diagnosed with Covid-19, had a mild course of the disease, and fully recovered from the infection. | 2020-05-30 |
| 32417164 | The treatment of sleep disorders has been strongly impacted by the COVID-19 pandemic. […] In this document, the French Association of Otorhinolaryngology and Sleep disorders (AFSORL) and the French Society of Otorhinolaryngology (SFORL) put forward a summary of the measures for continuing the treatment of sleep apnoea syndrome in these new practice conditions. […] Emphasis is placed on teleconsultation, methods of nocturnal sleep studies, the conditions for treatment by continuous positive airway pressure (CPAP) ventilation, and the postponement of more invasive treatments. | 2020-05-20 |
| 32417210 | Compared with patients in discharged group, the patients in un-discharged/died group suffered from decreased counts of total T lymphocytes, CD4 + T lymphocytes, CD8 + T lymphocytes, as well as NK cells at 2 weeks after treatment. […] Lymphopenia and eosinopenia may serve as predictors of disease severity and disease progression in COVID-19 patients, and enhancing the cellular immunity may contribute to COVID-19 treatment. […] Thus, PBICs might become a sentinel of COVID-19, and it deserves attention during COVID-19 treatment. | 2020-05-31 |
| 32417380 | Demographic, clinical, laboratory, radiologic, treatment, and mortality data were collected and analyzed. | 2020-05-26 |
| 32417555 | This will allow to reveal true scale of Covid-19 outbreak associated with population link to a specific wastewater treatment plant. | 2020-05-28 |
| 32417708 | The role of hydroxychloroquine (HCQ) in the treatment of COVID-19 is not fully known. | 2020-05-27 |
| 32417709 | This is a narrative mini-review with Pubmed search until April 23, 2020 using the keywords COVID-19, SARS-CoV-2, treatment of coronavirus and following terms: diabetes mellitus, obesity, arterial hypertension, ACE-inhibitors, cytokine storm, immune response and vitamin D. […] Currently, since there is no proven and effective antiviral therapy for SARS-CoV-2, the efforts should focus on controlling inflammatory response and reduce the risks of associated complications. | 2020-05-27 |
| 32417870 | Treatment of the infected requires decisions in resource constraint situation particularly ICU beds and ventilators. | 2020-05-21 |
| 32418028 | These observations warrant further well-designed studies, yet we believe it is time for a global consideration of sampling all asymptomatic patients before surgical treatment. | 2020-05-20 |
| 32418114 | All 550 patients received comparable basic treatments including antiviral drugs and antibiotics, and 48 of them were treated with oral HCQ treatment (200 mg twice a day for 7-10 days) in addition to the basic treatments. […] The levels of inflammatory cytokine IL-6 were significantly reduced from 22.2 (8.3-118.9) pg mL-1 at the beginning of the treatment to 5.2 (3.0-23.4) pg mL-1 (P<0.05) at the end of the treatment in the HCQ group but there is no change in the NHCQ group. […] Therefore, HCQ should be prescribed as a part of treatment for critically ill COVID-19 patients, with possible outcome of saving lives. hydroxychloroquine, IL-6, mortalities, COVID-19. | 2020-05-20 |
| 32418146 | Main themes encompassed testing strategies and results (n = 4), changes in use of current therapeutics (n = 3), preventive measurements of transmission and management of COVID-19 (n = 3), and changes in standard clinical care (n = 3). | 2020-05-20 |
| 32418181 | COVID-19 infection has shown rapid growth worldwide, and different therapies have been proposed for treatment, in particular, the combination of immune response modulating drugs such as chloroquine and hydroxychloroquine (antimalarials) alone or in combination with azithromycin. | 2020-05-20 |
| 32418190 | At present, there is no definitive antiviral treatment for coronavirus disease 2019 (COVID-19). […] Nasal swab SARS-CoV-2 RNA became negative in three of four patients after 3 days of therapy. | 2020-05-20 |
| 32418199 | Many factors have been associated with both altered ACE2 expression and COVID-19 severity and progression, including age, sex, ethnicity, medication and several co-morbidities, such as cardiovascular disease and metabolic syndrome. […] Identifying pathologic changes caused by SARS-CoV-2 infection is crucially important as it has major implications for understanding COVID-19 pathophysiology and the development of evidence-based treatment strategies. […] Finally, we highlight a selection of potential treatment modalities for COVID-19. | 2020-05-21 |
| 32418288 | A progressive clinical improvement along with a reduction of CSF parameters was observed after high-dose steroid treatment, thus arguing for an inflammatory-mediated brain involvement related to Covid-19. | 2020-05-17 |
| 32418377 | However, attention should be paid to acute kidney injury of the elderly patients in the diagnosis and treatment of COVID-19. 目的： 分析新型冠状病毒肺炎（COVID-19）与肾损伤的关系。 | 2020-05-17 |
| 32418446 | We report a series of febrile pediatric patients with acute heart failure potentially associated with SARS-CoV-2 infection and the multisystem inflammatory syndrome in children (MIS-C) as defined by the US Centers for Disease Control. Methods: Over a two-month period contemporary with the SARS-CoV-2 pandemic in France and Switzerland, we retrospectively collected clinical, biological, therapeutic, and early outcomes data in children who were admitted to pediatric intensive care units in 14 centers for cardiogenic shock, left ventricular dysfunction and severe inflammatory state. Results: Thirty-five children were identified and included in the study. […] All patients received intravenous immune globulin, with adjunctive steroid therapy used in one third. […] Treatment with immune globulin appears to be associated with recovery of left ventricular systolic function. | 2020-05-18 |
| 32418460 | Due to its highly contagious nature and unprecedented global spread, its aggressive clinical presentation and the lack of effective treatment, SARS-CoV-2 infection is causing the losses of thousands of lives and imparting unparalleled strains on healthcare systems around the world. | 2020-05-18 |
| 32418463 | Medicine and public health have traditionally separated the prevention and treatment of communicable and non-communicable diseases. | 2020-05-18 |
| 32418532 | The track for a possible COVID-19 treatment would be to target RAS using specific candidate chemotherapeutic drugs. | 2020-05-18 |
| 32418728 | Non-steroidal anti-inflammatory drugs (NSAIDs) have an optional prescription status that has resulted in frequent use, in particular for the symptomatic treatment of fever and non-rheumatic pain. […] First, the clinical observations of the French Pharmacovigilance Network showed that severe bacterial infections can occur even after a short NSAID treatment, and even if the NSAID is associated with an antibiotic. […] Therefore, in case of infection, symptomatic treatment with NSAIDs for non-severe symptoms (fever, pain, or myalgia) is not to be recommended, given a range of clinical and scientific arguments supporting an increased risk of severe bacterial complication. | 2020-05-20 |
| 32418773 | A proposal to adapt treatment strategies was made for the main GI oncology situations. […] Healthcare teams need to consider adapting treatment sequences when feasible and according to the epidemic situation. | 2020-05-29 |
| 32418885 | Currently, no specific prophylactic and therapeutic treatment is available. […] No evidence from randomized clinical trials (RCTs) that a treatment may ameliorate the clinical outcome of patients with COVID-19 exists with the only exception of preliminary evidence from remdesivir trials. […] Here, we present evidence from the literature and a compelling hypothesis on the potential immunomodulatory, iron chelating and anti-oxidant effects of iron chelators in the treatment of COVID-19 and its complications. […] Both retrospective analyses of data in electronic health records, as well as proof of concept studies in humans and large RCTs are needed to fully elucidate the efficacy and safety of iron chelating agents in the therapeutic armamentarium of COVID-19, probably as an adjunctive treatment. | 2020-05-28 |
| 32418894 | Recent global outbreak of the pandemic caused by coronavirus (COVID-19) emphasizes the urgent need for novel antiviral therapeutics. […] The review elaborates the mechanism of action, safety (side effects, adverse effects, toxicity) and details of clinical trials for chloroquine and hydroxychloroquine to benefit the clinicians, medicinal chemist, pharmacologist actively involved in controlling the pandemic and to provide therapeutics for the treatment of COVID-19 infection. | 2020-05-29 |
| 32418917 | Presently, few treatment options exist and the availability of effective vaccines is at least one year away. […] There is an urgent need to find currently available, effective therapies in the treatment of patients with COVID-19 infection. […] In this review, we compare and contrast the use of intravenous immunoglobulin and hyperimmune globulin in the treatment of COVID-19 infection. | 2020-05-29 |
| 32419272 | In Taiwan, a COVID-19 Open Science Platform adheres to the spirit of open science: sharing sources, data, and methods to promote progress in academic research while corroborating findings from various disciplines has established in mid-February 2020, for collaborative research in support of the development of detection methods, therapeutics, and a vaccine for COVID-19. […] Research priorities include infection control, epidemiology, clinical characterization and management, detection methods (including viral RNA detection, viral antigen detection, and serum antibody detection), therapeutics (neutralizing antibody and small molecule drugs), vaccines, and SARS-CoV-2 pathogenesis. | 2020-05-18 |
| 32419401 | In future outbreaks of emerging infectious diseases, efforts should be focused toward the provision of continued ED treatment with the implementation of revised triage and surveillance protocols. | 2020-05-19 |
| 32419524 | However, apart from supportive care by respirators, no standard medical therapy is validated.Areas covered: This paper presents old drugs with potential in vitro efficacy against SARS-CoV-2. […] The in vitro database, adverse effects, and potential toxicities of these drugs are reviewed regarding their feasibility of clinical prescription for the treatment of patients with COVID-19. […] To obtain convincing recommendations, we referred to opinions from the US National Institute of Health regarding drugs repurposed for COVID-19 therapy.Expert opinion: Although strong evidence of well-designed randomized controlled studies regarding COVID-19 therapy is presently lacking, remdesivir, teicoplanin, hydroxychloroquine (not in combination with azithromycin), and ivermectin might be effective antiviral drugs and are deemed promising candidates for controlling SARS-CoV-2. […] In addition, tocilizumab might be considered as the supplementary treatment for COVID-19 patients with cytokine release syndrome. […] In future, clinical trials regarding a combination of potentially effective drugs against SARS-CoV-2 need to be conducted to establish the optimal regimen for the treatment of patients with moderate-to-severe COVID-19. | 2020-05-18 |
| 32419544 | Since there is no approved treatment or drug for this disease, prevention of infection and breaking the chain of transmission plays a crucial role. | 2020-05-18 |
| 32419705 | COVID-19 pandemic caused not only many deaths around the world but also made evident technical limitations of hospital and intensive care units (ICU). | 2020-05-18 |
| 32419715 | The Spanish Working Group on Crohn’s Disease and Ulcerative Colitis (GETECCU) and the Spanish Nurses Working Group on Inflammatory Bowel Disease (GETEII) have prepared this document as a practical response to some common questions about the treatment of these patients. | 2020-05-18 |
| 32419749 | Timely treatment of acute stroke is critical to prevent disability. | 2020-05-22 |
| 32419750 | Additionally, lockdown and social distancing may pose hurdles in the provision of optimum medical therapy, particularly if patients experience motor and non-motor deteriorations due to diverse reasons. | 2020-05-22 |
| 32419752 | Hence physicians should be made aware of the new rules of the game in treating migraines during this time of the pandemic so that these patients get optimum treatment and care and don’t feel left out. | 2020-05-22 |
| 32419767 | Thus, timely treatment of diabetic foot ulcers is extremely important. […] However, timely patient treatment during the COVID-19 pandemic is particularly challenging, because of the higher volume of patients and the need to ensure safety of medical personnel. […] This article describes a proposed strategy for diagnosis and treatment of diabetic foot ulcers, based on experiences with infection and control strategies during the COVID-19 pandemic in China. | 2020-05-18 |
| 32419838 | A knowledge-based analysis strongly suggests a possible repositioning of the anti-HCV direct antiviral agent (DAA) Sofosbuvir as treatment for SARS-CoV-2. | 2020-05-22 |
| 32419840 | Another main threat is an increased risk for parental mental illness, domestic violence and child maltreatment. […] To maintain regular and emergency child and adolescent psychiatric treatment during the pandemic is a major challenge but is necessary for limiting long-term consequences for the mental health of children and adolescents. […] Urgent research questions comprise understanding the mental health effects of social distancing and economic pressure, identifying risk and resilience factors, and preventing long-term consequences, including-but not restricted to-child maltreatment. | 2020-05-22 |
| 32419926 | Actin protein was also suggested as a host factor that participates in cell entry and pathogenesis of SARS-CoV-2; therefore, drugs modulating biological activity of this protein (e.g. ibuprofen) were suggested as potential candidates for treatment of this viral infection. | 2020-05-26 |
| 32419998 | The goal of this work is to use our experience at a large, academic medical center as a lens for interpreting the many looming issues specific to radiosurgery and its role in the treatment of brain and spine disorders. | 2020-05-22 |
| 32420049 | Mesenchymal stem cell therapy offers a promising approach towards mitigating the delirious effects of the infection in the COVID-19 patients. […] This therapy has shown to reduce the expression of pro-inflammatory cytokines as well as repair of damaged tissues in COVID-19 patients. […] This review has been organized to put forward the positive aruments and implications in support of mesenchymal stem cell therapy as a necessary approach for treating COVID-19 patients. | 2020-05-22 |
| 32420073 | At last, more attention to the protection of cancer patients and give priority to the treatment of infected cancer patients. | 2020-05-22 |
| 32420305 | Following treatment with early non-invasive ventilation and a bundle pharmacotherapy, she recovered with a good outcome. […] Early non-invasive ventilation with a bundle pharmacotherapy may be an effective treatment regimen for the broader population of patients with COVID-19. | 2020-05-22 |
| 32420607 | The severity of COVID-19 disease has a wide range and varies from asymptomatic to critical severe, clinical researches reported that 10-15% of the patients were in the severe situation and required a great deal of attention of treatment and nursing (WHO-China-Joint-Mission 2020). | 2020-05-18 |
| 32420609 |
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2020-05-18 |
| 32420631 | The application of evidence-based approaches to the identification and management of treatment and tumor-related toxicities has embraced the use of validated patient-reported outcomes instruments, health promotion, and care coordination. […] In this manuscript, we describe how our multidisciplinary team of survivorship providers has accommodated to the need to provide patients with social distancing while acknowledging the importance of continued care during treatment and through the spectrum of survivorship. | 2020-05-18 |
| 32420637 | Over thousand clinical trials with COVID-19 patients are already listed in ClinicalTrials.com, some of them for assessing the utility of therapeutics approved for other conditions. […] A much faster and by far more efficient method for rapidly identifying approved therapeutics that can be repurposed for treating COVID-19 patients is data mining their past and current electronic health and prescription records for identifying drugs that may protect infected individuals from severe COVID-19 symptoms. | 2020-05-19 |
| 32420691 | Over the last several decades, as technology has developed to purify and manufacture plasma-derived immunoglobulin (IG) as a drug therapy, hyperimmune globulin (H-IG) formulations have been used as the second line of passive immunotherapies against these diseases. | 2020-05-18 |
| 32420705 | However, there is no one-size-fits-all approach for monitoring, treatment and referral decisions. | 2020-05-20 |
| 32420710 | We retrospectively assessed 169 consecutive patients with laboratory‑ confirmed COVID‑ 19 with regard to their clinical manifestations, radiological findings, treatment, complications, and outcomes. | 2020-05-29 |
| 32420751 | Since the outbreak of Corona Virus Disease 2019 (COVID-19) in Hubei province, the epidemic scale has increased rapidly, and no effective antiviral drug therapy has been identified yet. […] This study aimed to evaluate the adjuvant efficacy of Natural Herbal Medicine (NHM) combined with Western medicine in the treatment of COVID-19. […] A total of 22 of the 36 confirmed patients were included in this study, split into two groups of 11: the NHM group (NHM combined standard Western medicine treatment) and control group (standard Western medicine treatment alone). […] Our results suggest that NHM could improve the clinical symptoms of COVID-19 patients and may be effective in treating COVID-19; thus, a larger, prospective, randomized, controlled clinical trial should be conducted to further evaluate the adjuvant efficacy of NHM in the treatment of COVID-19. | 2020-05-18 |
| 32420777 | Introduction: With the emergence of novel coronavirus disease 2019 (COVID-19) in many countries, medical resources currently focus on the treatment of confirmed patients and screening of suspected cases. […] She was given antiviral and symptomatic supportive treatment. | 2020-05-18 |
| 32420788 | With the spread of the novel coronavirus, the outpatient lines of hospitals have mostly shut down, which means that routine clinical diagnosis and treatment for autoimmune bullous diseases patients have been disturbed. […] Clinicians should strengthen their communication with patients, pay attention to changes in patients’ conditions, and carefully adjust the treatment strategy, while protecting against the novel coronavirus infection, to ensure the continuity, safety, and effectiveness of autoimmune bullous diseases treatment. | 2020-05-18 |
| 32420913 | We offer to the forensic odontologists’ community a short summary of some old and new hints on the treatment of dead bodies in the autopsy room during this pandemic emergency time. | 2020-05-20 |
| 32420927 | From the preliminary data of this study, it appears that the Bari Polyclinic has adopted the same therapeutic strategies started in China in the previous months, believing early diagnosis and treatment to be a strength in the battle against COVID-19. | 2020-05-26 |
| 32420936 | Along with extensive public health measures, an unprecedented global effort in identifying effective drugs for the treatment is being implemented. | 2020-05-26 |
| 32420939 | This narrative review starts from diagnostic evaluation, continues with adapted pharmacologic treatment and ends with the recovery phase targeting the nutrition and physical exercise. […] We finally considered timing and selection of treatment, which depend on the disease phase, co-administration of other drugs and require the monitoring of renal, liver and cardiac function. | 2020-05-26 |
| 32420944 | MicroRNAs (miRNA9) systems are potent post-transcriptional gene expression regulators that are important modulators of viral infections, and could play an important role in the treatment of viral infections. | 2020-05-22 |
| 32420958 | Sofosbuvir may be a potential option in the treatment of COVID-19 based on the similarity between the replication mechanisms of the HCV and the coronavirus. […] Efficacy and safety of sofosbuvir in treatment of COVID-19 may be considered in future clinical studies. | 2020-05-22 |
| 32421258 | Information on demographic characteristics, exposure history, ocular symptoms, eye drop medication, eye protections, chronic eye diseases, systemic concomitant symptoms, radiologic findings and SARS-CoV-2 detection in nasopharyngeal swabs by real-time PCR was collected from questionnaires and electronic medical records. | 2020-05-18 |
| 32421292 | The race to minimize the damage caused by COVID-19 requires that we obtain knowledge about the disease and its treatment or prevention, how to best safeguard public health and avoid overwhelming the health care system, and how to minimize the societal damage caused by substantial disruption of the economy. | 2020-05-29 |
| 32421381 | Background: To investigate deep vein thrombosis (DVT) in hospitalized patients with coronavirus disease 2019 (COVID-19), we performed a single institutional study to evaluate its prevalence, risk factors, prognosis, and potential thromboprophylaxis strategies in a large referral and treatment center. Methods: We studied a total of 143 patients with COVID-19 from January 29 to February 29, 2020. | 2020-05-18 |
| 32421539 | Chest CT has a higher sensitivity and can play an essential role in the diagnosis and treatment of the disease. | 2020-05-22 |
| 32421541 | Although aerosol therapy is a mainstay procedure used to treat pulmonary diseases at home and healthcare settings, it has a potential for fugitive emissions during therapy due to the generation of aerosols and droplets as a source of respiratory pathogens. […] This has been a real concern for caregivers and healthcare professionals who are susceptible to unintended inhalation of fugitive emissions during therapy. […] Due to a scarcity of information in this area of clinical practice, the purpose of this paper is to explain how to deliver aerosolized medications to mild-, sub-intensive, and intensive-care patients with COVID-19 and how to protect staff from exposure to exhaled droplets during aerosol therapy. | 2020-05-22 |
| 32421627 | As a matter of fact, testing accelerates life-saving decisions on treatment and isolation of COVID-19 patients in an early stage, and thereby, decelerating or even preventing the spread of such emerging infectious diseases. | 2020-05-29 |
| 32422062 | The role of angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin-receptor blockers (ARBs) in COVID-19 disease susceptibility, severity, and treatment is unclear. […] To evaluate, on an ongoing basis, whether use of ACEIs or ARBs either increases risk for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection or is associated with worse COVID-19 disease outcomes, and to assess the efficacy of these medications for COVID-19 treatment. […] Fourteen observational studies, involving a total of 23 565 adults with COVID-19, showed consistent evidence that neither medication was associated with more severe COVID-19 illness (high-certainty evidence). […] Four registered randomized trials plan to evaluate ACEIs and ARBs for treatment of COVID-19. […] Whether these medications increase the risk for mild or asymptomatic disease or are beneficial in COVID-19 treatment remains uncertain. | 2020-05-20 |
| 32422076 | Ten of the 11 patients received prophylactic anticoagulant therapy; venous thromboembolism was not clinically suspected antemortem in any of the patients. […] Studies are needed to further understand the thrombotic complications of COVID-19, together with the roles for strict thrombosis prophylaxis, laboratory, and imaging studies and early anticoagulant therapy for suspected pulmonary arterial thrombosis or thromboembolism. | 2020-05-20 |
| 32422146 | We determined effects of IL-13 treatment on ACE2 and TMPRSS2 expression ex vivo in primary airway epithelial cells from participants with and without type 2 asthma obtained by bronchoscopy. | 2020-05-20 |
| 32422178 | However, the role of antifibrotic therapy in patients with IPF who contract SARS-CoV-2 infection, and the scientific rationale for their continuation or cessation, is poorly defined. | 2020-05-22 |
| 32422287 | We herein report a rare case of the ruptured popliteal artery aneurysm in an 89-year-old man, whose recovery after surgical treatment was complicated with acute respiratory distress syndrome secondary to confirmed infection with SARS-CoV-2. | 2020-05-30 |
| 32422288 | Endovascular treatment and early anticoagulation are the key for success for vascular emergencies in COVID-19 patients, despite the risk of late endoleak. | 2020-05-22 |
| 32422305 | Until now, there is not a specific and definitive treatment for this pathology that worries the world population, especially the older adults who constitute the main risk group. | 2020-05-29 |
| 32422331 | In a few hospitals, existing neurosurgical and medical intensive care units have been converted to isolation intensive care units. | 2020-05-29 |
| 32422349 | Further clinical trials are required to ascertain the need for early therapeutic anticoagulation or fibrinolytic therapy to address this state of fibrinolysis shutdown. | 2020-05-22 |
| 32422364 | A major consideration in the delivery of cancer care during the pandemic is to balance the risk of patient exposure and infection with the need to provide effective cancer treatment. […] Infection at any level for patients or providers can cause considerable disruption to even the most effective treatment plans. […] The purpose of this manuscript is to present a practical multidisciplinary and international overview to assist in treatment for lung cancer patients during this pandemic, with the caveat that evidence is lacking in many areas. | 2020-05-31 |
| 32422376 | We report the first successful treatment with the IL-1 receptor antagonist anakinra, in association with the most promising and available antiviral therapy, of a severe case of novel coronavirus disease 2019 (COVID-19). […] We describe the diagnosis, clinical course, and management of the case, including the respiratory failure at presentation, the progression to a scenario characterized by profound inflammatory dysregulation similar to that observed during macrophage activation syndrome, and the clinical improvement after treatment with the IL-1 receptor antagonist anakinra. […] This case highlights the high tolerability and the interesting immunomodulatory profile of the IL-1 receptor antagonist anakinra in the setting of severe COVID-19 associated with remdesivir therapy. […] Further studies are needed to confirm the safety and efficacy of this combination strategy in the treatment of this emerging infection. | 2020-05-20 |
| 32422384 | Furthermore, we present an overview of diagnostic approaches and treatment of this disease according to available findings. | 2020-05-22 |
| 32422426 | Psychiatrists, neurologists and physicians in general should be aware of this symptom presentation in order to avoid mistreatment, given that persistent olfactory dysfunction might increase the risks of nutritional deficit and lead to development of adjustment disorders. | 2020-05-26 |
| 32422645 | These results pave the way for using S309- and S309-containing antibody cocktails for prophylaxis in individuals at high risk of exposure or as a post-exposure therapy to limit or treat severe disease. | 2020-05-18 |
| 32422662 | Especially, in preparation for expected mass casualty incident it is necessary to distinguish early and efficiently between outpatient and inpatient treatment including the need for intensive care therapy. […] During the first two weeks after implementing this model in our normal operation at the emergency department, we had an efficient selectivity between need for inpatient and outpatient treatment. 16 patients were classified as “inpatients” according to initial assessment. | 2020-05-18 |
| 32422983 | Despite the improvement and reinforcement of any method of study in every field of medicine and science, encouraging the autopsy practice as a tool of investigation could also therefore, help physicians to define an effective treatment to reduce mortality. | 2020-05-19 |
| 32423024 | There is currently no established consensus on the standard of care in the pharmacological treatment of COVID-19 patients. | 2020-05-19 |
| 32423027 | Whereas plasma therapy attracts much interest, the European project Discovery focuses on the potentialities of small molecules like remdesivir, the combination of lopinavir/ritonavir, hydroxychloroquine, and chloroquine. | 2020-05-19 |
| 32423150 | In addition to the medical practice for treatment and immunization, it is vital to have a thorough understanding of community spread phenomena as related research reports 17.9-30.8% confirmed cases to remain asymptomatic. | 2020-05-26 |
| 32423250 | Cardiac manifestations reported include tachycardia, bradycardia, arrhythmias, and myocardial injury, secondary to both systemic infection and treatment. | 2020-05-19 |
| 32423298 | In our otolaryngology unit, between March 10 and April 28, 2020, we performed 96 surgical procedures; they mainly consisted in diagnosis and treatment of malignant tumors of the head and neck (77%), management of acute upper airway obstruction in adults and children (14.7%), drainage of abscesses of the head and neck (6.2%), and treatment of nasal bone fractures (2.1%). | 2020-05-19 |
| 32423324 | There is not any standard treatment for coronavirus infection 2019; however, there are promising data for hydroxychloroquine and some anti-retroviral drugs. […] It is impossible to say that blockade of PD-1/PDL-1pathway is a treatment option for COVID-19; however, we want to share our experience. | 2020-05-19 |
| 32423449 | Upon administration by the intravenous route, the cells travel directly to the lungs where the majority are sequestered, a great benefit for the treatment of pulmonary disease. […] Adipose-derived stem cells (ASC), an abundant type of MSC, are proposed as a therapeutic option for the treatment of COVID-19 in order to reduce morbidity and mortality. […] Cellular based therapies hold great promise for the treatment of COVID-19. […] This literature summary reviews the scientific rationale and need for clinical studies of adipose-derived stem cells and other types of mesenchymal stem cells in the treatment of patients who suffer with COVID-19. | 2020-05-28 |
| 32423584 | No specific antiviral drug has been proven effective for treatment of patients with severe coronavirus disease 2019 (COVID-19). […] Primary analysis was done in the intention-to-treat (ITT) population and safety analysis was done in all patients who started their assigned treatment. […] Between Feb 6, 2020, and March 12, 2020, 237 patients were enrolled and randomly assigned to a treatment group (158 to remdesivir and 79 to placebo); one patient in the placebo group who withdrew after randomisation was not included in the ITT population. | 2020-05-29 |
| 32423664 | Early identification, timely and effective treatments, and maintenance of hemodynamics and electrophysiological stability are of great significance on effective treatment and long-term prognosis. | 2020-05-22 |
| 32423842 | Due to the wide availability, rapid execution, low cost, and possibility of being acquired at the patient’s bed, chest X-Ray is a fundamental tool in the diagnosis, follow-up and evaluation of the treatment effectiveness of patients with pneumonia, also in the context of COVID-19 infection. | 2020-05-22 |
| 32423899 | Since the availability of resources for diagnostic procedures, surgery and postoperative care, systemic therapy and radiotherapy may differ, the authors have separated the prioritisation analyses. | 2020-05-21 |
| 32423903 | We describe three cases of thromboembolism refractory to heparin treatment, the incidence of VTE in an inpatient cohort, and a case-control study to identify risk factors associated with VTE. | 2020-05-19 |
| 32423917 | Although over 90% of infected individuals are asymptomatic or manifest noncritical symptoms and will recover from the infection, those individuals presenting with critical symptoms are in urgent need of effective treatment options. […] Emerging data related to mechanism of severity and potential therapies for patients presenting with severe symptoms are scattered and therefore require a comprehensive analysis to focus research on developing effective therapeutics. […] Therefore, the use of therapeutics that modulate inflammation without compromising the adaptive immune response could be the most effective therapeutic strategy. | 2020-05-19 |
| 32423970 | This viewpoint aims at discussing the pitfalls and issues to be considered with regard to the use of immunomodulating agents in COVID-19, such as timing of treatment based on the viral load and the extent of cytokine/ferritin overexpression. | 2020-05-26 |
| 32424085 | The findings, while drawn from a demographically unique sample, suggest that, to mitigate the indirect effects of COVID-19, lapses in medical care and medication use must be minimized, and public health resources should be directed to those with preexisting medical conditions, their social networks, and the bereaved. | 2020-05-19 |
| 32424293 | Other co-variates such as age and TKI-therapy duration were not significantly associated with an increased risk of developing COVID-19. | 2020-05-22 |
| 32424429 | Extracorporeal membrane oxygenation (ECMO) represents a life-saving therapy in cases of refractory hypoxia and has been utilized in patients suffering from the most severe forms of coronavirus disease 2019 (COVID-19). […] We performed a retrospective analysis of 2 cases of devastating intracranial hemorrhage in patients on VV-ECMO for the treatment of COVID-19. […] Collected data included clinical history, laboratory results, treatment, and review of all available imaging. | 2020-05-19 |
| 32424616 | Clinical characteristics and treatment were retrospective analyzed. | 2020-05-22 |
| 32424845 | No approved vaccine or treatment are available for this virus. […] Scientific attention is needed toward this agent to address for the treatment of COVID-19. | 2020-05-28 |
| 32424977 | Patients rated their telemedicine visit as “excellent” or “very good” across measures (91.6-95.0%) including addressing concerns, communication, developing a treatment plan, convenience, and satisfaction. | 2020-05-19 |
| 32424990 | Although the German Society of Urology (“DGU”) has published a recommendation to evaluate the need for a timely therapy in prostate cancer (PCa) patients according to D’Amico risk groups on the 2nd of April 2020, up to now no compulsory directives exist regarding omitting radical prostatectomy (RP) during the COVID-19 pandemic. | 2020-05-19 |
| 32425002 | We collected data from medical records of confirmed COVID-19 patients in Zhejiang Province from Jan. 17 to Feb. 7, 2020 and analyzed epidemiological, clinical, and treatment data of those with and without recorded recent exposure in Wuhan. | 2020-05-20 |
| 32425010 | Endoscopic diagnosis and treatment constitute an irreplaceable part in the handling of severe COVID-19 cases. […] Based on the experience we attained from the 12 severe COVID-19 cases in our hospital who underwent endoscopy 23 times in total, the article provides an improved version of endoscopic reprocessing guidelines for bedside endoscopic diagnosis and treatment on COVID-19 patients for reference. | 2020-05-20 |
| 32425013 | Despite the exact pathophysiological mechanism of coronavirus-induced thromboembolism needs to be further investigated, this finding suggests that it is good practice to assess the risk of thrombosis in COVID-19 patients to improvethe clinical management in terms of anticoagulation therapy. | 2020-05-20 |
| 32425051 | COVID-19 is a potentially fatal illness with no proven therapy beyond excellent supportive care. | 2020-05-22 |
| 32425152 | The novel severe acute respiratory syndrome coronavirus 2 is the cause of Coronavirus Disease 2019, a new illness with no effective treatment or vaccine that has reached pandemic proportions. | 2020-05-19 |
| 32425199 | Various drugs are under investigation for its treatment. | 2020-05-22 |
| 32425222 | For this purpose, we plan a pilot, multicenter, randomized, single blind, controlled, phase III therapeutic trial (standard treatment vs. […] CPZ + standard treatment). […] This repurposing strategy also avoids numerous developmental and experimental steps, and could save precious time to rapidly establish an anti-COVID-19 therapy with well-known, limited and easily managed side effects. | 2020-05-19 |
| 32425234 | TNF antagonist treatment was not associated with severe COVID-19 (aOR 0.9, 95% CI 0.4-2.2). | 2020-05-22 |
| 32425237 | Conservative treatment should be the first line of treatment except for those requiring urgent/emergent care. | 2020-05-22 |
| 32425244 | In the present study, we devised a mathematical model focusing on the treatment of people complaining of influenza-like-illness (ILI) symptoms, potentially at risk of contracting COVID-19 or other emerging/re-emerging respiratory infectious agents during their admission at the health-care setting, who will occupy the detection kits causing a severe shortage of testing resources. | 2020-05-22 |
| 32425246 | The only FDA approved drug to treat COVID-19 is remdesivir, and other off-label medications used include chloroquine and hydroxychloroquine, tocilizumab, lopinavir/ritonavir, favipiravir, convalescent plasma therapy, azithromycin, vitamin C, corticosteroids, interferon and colchicine. | 2020-05-22 |
| 32425259 | Medical history, clinical symptoms, laboratory tests, CT imaging, and treatment were obtained through a standardized data collection form, and then independently reviewed by two investigators. 2 of 91 cases were infected with COVID-19. […] Early identification and properly treatment are very important to prevent IgG4-RD patients with COVID-19 from progression to severe condition. | 2020-05-29 |
| 32425268 | Propensity score inverse probability of treatment weighting was used to balance the measured demographics between the two groups, and disease-free survival (DFS) and overall survival (OS) were assessed. | 2020-05-22 |
| 32425269 | This suggests the possibility of using IL-6 or CRP levels to guide escalation of treatment in patients with COVID-19 related hyperinflammatory syndrome. | 2020-05-19 |
| 32425275 | She was administered olanzapine 10 mg with a significant psychopathological improvements being discharged with indications to maintain the treatment. | 2020-05-26 |
| 32425294 | In this review we compare the clinical features, diagnosis, and pathogenesis of COVID-CSS with other hematological CSS, namely secondary hemophagocytic lymphohistiocytosis (sHLH), idiopathic multicentric Castleman disease (iMCD), and CAR-T cell therapy associated Cytokine Release Syndrome (CRS). […] Novel therapeutics targeting cytokines or inhibiting cell signaling pathways have now become the mainstay of treatment in these CSS. | 2020-05-22 |
| 32425305 | Exploring compounds that could offer a breakthrough in treatment is the need of the hour. […] The paper proposes evidence for the potential use of diethylcarbamazine (DEC) in the treatment of COVID-19. | 2020-05-22 |
| 32425326 | The majority (85, 68.5%) classified their study as interventional, 37 (29.8%) classified as observational and one (0.8%) each classified their study as either expanded access:individual patients | treatment IND/Protocol or expanded access:intermediate-size population | treatment IND/Protocol. | 2020-05-22 |
| 32425336 | Older patients with severe illness during treatment were more prone to develop fibrosis according to thin-section CT results. | 2020-05-22 |
| 32425361 | Patients were randomized to receive usual treatment alone or in combination with LH capsules (4 capsules, thrice daily) for 14 days. […] We included 284 patients (142 each in treatment and control group) in the full-analysis set. […] The recovery rate was significantly higher in treatment group as compared with control group (91.5% vs. […] The median time to symptom recovery was markedly shorter in treatment group (median: 7 vs. 10 days, P<0.001). […] Time to recovery of fever (2 vs. 3 days), fatigue (3 vs. 6 days) and coughing (7 vs. 10 days) was also significantly shorter in treatment group (all P<0.001). […] 66.2%, P=0.017) was also higher in treatment group. | 2020-05-22 |
| 32425428 | We have explored the possibilities of confronting the ongoing COVID-19 pandemic by implementing the IoMT approach while offering treatment to orthopaedic patients. | 2020-05-19 |
| 32425429 | On the advent of COVID-19 pandemic, it has been acknowledged by the British Orthopaedic Association (BOA) emergency COVID-19 and the National Health Service England (NHSE) guidelines to manage urgent orthopaedic and trauma conditions pragmatically balancing optimum treatment of patients against clinical safety with resource utilization . | 2020-05-22 |
| 32425471 | Given these traits, Qigong has the potential to play a role in the prevention, treatment, and rehabilitation of respiratory infections, such as COVID-19. | 2020-05-22 |
| 32425485 | There is a trend towards biopsychosocial care of elderly people in all settings where they are, adapting care and personalizing decisions on hospital admissions, palliative care, among other criteria, to years adjusted to quality of life, as well as alternatives for monitoring and treatment of COVID-19 pathology and others existing in this population group. | 2020-05-19 |
| 32425486 | Among the main recommendations according to the available evidence are air exchange in rooms as a measure to reduce the risk of infection among patients; reinforcement of measures in intensive care units; follow-up of positive case contacts; and adequate training of professionals. | 2020-05-19 |
| 32425488 | Research on prevention and treatment in the pediatric age needs to be developed to improve the available recommendations. | 2020-05-19 |
| 32425489 | The recommendations were grouped into 9 subjects: Prevention of infection in pregnant women, Prevention of infection in health care personnel attending pregnant women, Form of presentation and severity in pregnant women, Maternal-fetal transmission (vertical and perinatal), Maternal-fetal control of the pregnant woman infected with COVID-19, Control of the severely pregnant woman with COVID-19, Treatment of the pregnant woman with COVID-19, Management and route of termination of labor, Neonatal outcomes in women with COVID-19 and Breastfeeding. | 2020-05-19 |
| 32425491 | The purpose of this review is to study the most relevant and current information on the pathogen, as well as epidemiology, pathology, clinical features, transmission, prevention, and treatment of the disease. | 2020-05-19 |
| 32425631 | A lockdown strategy or combination of case isolation, home quarantine, social distancing of individuals >70 years, and telework interventions may keep treatment demand below capacity. | 2020-05-22 |
| 32425636 | Clinical characteristics, laboratory findings, treatment and outcome were retrieved. | 2020-05-19 |
| 32425638 | We focus this editorial specifically on the background to, and the rationale for, the use and evaluation of mesenchymal stromal (Stem) cells (MSCs) in treatment trials of patients with severe COVID-19 disease. […] MSCs should also be trialed for treatment of severe cases of MERS where mortality rates are upto 34% and MERS-CoV remains a WHO priority Blueprint pathogen. […] MSC therapy could turn out to be an important contribution to bringing an end to the high COVID-19 and MERS death rates. | 2020-05-19 |
| 32425651 | Therefore, in this review, we outline the epidemiology, clinical symptoms, diagnosis, treatment, prevention, possible immune response and role of thymus in children to combat the COVID-19 outbreak. | 2020-05-22 |
| 32425655 | On March 29th 2020, 97,689 cases of COVID-19 have been diagnosed only in Italy, with 73,880 actually positive cases, a daily increase of 3815 cases, 27,386 hospitalized and 3906 patients in intensive care units, causing a total of 10,779 known deaths. | 2020-05-19 |
| 32425658 | According to our model, this method would prevent a second peak and the number of intensive care units needed per day would be within the threshold of those currently available. | 2020-05-22 |
| 32425659 | The analysis unravel various amino acid mutations in the viral proteins which may provide an explanation for varying treatment efficacies of different inhibitory drugs and a future direction towards a combinatorial treatment therapies based on the kind of mutation in the viral genome. | 2020-05-22 |
| 32425662 | In the TOCI group, all received anti-viral therapy and 40% also received glucocorticoids. […] Despite the confounding factors, this suggests that therapy time in anti-cytokine randomized trials will be key. | 2020-05-22 |
| 32425701 | Finally, we demonstrate that ACE2 expression is responsive to inflammatory signaling and can be upregulated by viral infections or interferon treatment. | 2020-05-19 |
| 32425731 | We aimed to evaluate the perception of this in Celiac Disease (CeD) patients who require a lifelong gluten-free diet as a therapy. | 2020-05-22 |
| 32425880 | COVID-19 determines the need for healthcare in a large number of people in an extremely short time and, like a tsunami wave, overruns emergency, infectious diseases, and pneumology departments as well as intensive care units, choking healthcare services. | 2020-05-22 |
| 32425991 | Also, considerations to be considered in liver transplant patients or those having hepatocellular carcinoma or are under immunosuppressive therapy are being matter of analysis as information is being generated. | 2020-05-22 |
| 32425996 | This article reviews the characteristics, treatment, and outcomes of asymptomatic infections with COVID-19, hoping it would be helpful for early prevention and control of this severe public health threat worldwide. | 2020-05-22 |
| 32426001 | The 5 cases were put under colchicine treatment for IA crisis and had non-specific symptoms (headache, cough without dyspnoea, and arthralgias) with a positive SARS-CoV-2 test. | 2020-05-19 |
| 32426002 | In addition to anti-viral therapy and supportive treatment in critically ill patients, unique medications for this condition are also under investigation. […] Here we reviewed therapeutic options, including the antibody therapy that might be an immediate strategy for SARS-CoV-2 therapy. | 2020-05-19 |
| 32426020 | Contingencies should be in place for prioritization of existing patients, triaging and treatment of suspected patients, infection control, manpower management and novel strategies for inter-disciplinary communications and education in a hospital’s surgical unit during a pandemic. | 2020-05-31 |
| 32426090 | For the patients with severe asthma infected by SARS-CoV-2, the decision to maintain or postpone biologic therapy until the patient recovers should be a case-by-case based decision supported by a multidisciplinary team. | 2020-05-19 |
| 32426099 | With health care funders’ increasing approval of telehealth service as an emergency measure to provide continuity of care during the COVID-19 crisis, practicing behavior analysts have an unprecedented opportunity to demonstrate that essential, medically necessary behavior-analytic services can be provided via telehealth in a manner that maintains treatment integrity and produces meaningful client outcomes. […] This telehealth treatment selection guide was designed to assist practicing behavior analysts in determining an appropriate protocol for the delivery of 1:1 telehealth service (i.e., a behavior technician providing instruction directly to a client, with or without the assistance of the client’s caregiver, through videoconferencing). | 2020-05-22 |
| 32426111 | However, the COVID-19 outbreak may also represent a unique time when pulmonary hypertension experts have to weigh the risks and benefits of the diagnostic work-up including potential exposure to COVID-19 versus initiating targeted pulmonary arterial hypertension therapy in a select high-risk, high likelihood World Symposium Pulmonary Hypertension Group 1 pulmonary arterial hypertension patients. | 2020-05-22 |
| 32426200 | Although we are uncovering many facets of its disease spectrum, with rapidly emerging data, there is still limited knowledge of the sequelae of this infection, making treatment guidelines incomplete and resulting in serious unpredictable outcomes in patients at seemingly low risk, especially ones afflicted by neurological consequences. | 2020-05-22 |
| 32426209 | At first, it was thought that the patients who use immunmodulator therapy could be even at higher risks of disease complications. […] Therefore, several immunmodulators are currently being tested as potential treatment for COVID-19. : In this paper we report on a patient that has been treated with type 1 interferon for multiple sclerosis who developed COVID-19. : Despite using immunmodulator, the symptoms of the patient at hospitalization were mild and he did not show elevated D-dimer, and there was no lymphopenia. […] He was discharged to home-quarantine with no symptoms. : This report supports the idea of using type 1 interferon in the treatment could be effective in COVID-19 affected patients. | 2020-05-22 |
| 32426220 | Triage urgency was determined based on clinical assessment of urgency with which a patient would require medical treatment or surgical intervention. | 2020-05-22 |
| 32426231 | Following adequate therapy, the patient recovered completely after 8 weeks and was discharged from the hospital in good general condition. | 2020-05-22 |
| 32426243 | Remdesivir, as well as convalescent plasma therapy, are currently under investigation as potential therapies for patients with Coronavirus Disease 19 (COVID-19). […] In this case report we summarize the use of convalescent plasma therapy and then remdesivir as a late addition in the treatment of a critically ill obstetric patient with COVID-19. […] The patient subsequently improved, was extubated 5 days after initiation of remdesivir, was transitioned to room air 24 h later, and discharged at the completion of remdesivir therapy. | 2020-05-22 |
| 32426285 | Thus, in the extraordinary epidemiological scenario of the COVID-19 pandemic in Italy, older persons in cancer treatment are at particularly high risk of being severely affected by COVID-19. | 2020-05-22 |
| 32426292 | While certain aspects of care can be safely omitted or delayed, systemic therapy plays an important role in survival and quality of life for patients with advanced lung cancer; limiting access to systemic therapy will compromise cancer-related outcomes. […] Integrating oral therapeutics can permit patients to receive effective systemic treatment without the exposure risks associated with frequent infusions. […] Here, we review currently available oral cytotoxic agents with a potential role in the treatment of lung cancer. | 2020-05-22 |
| 32426362 | The high number of positive cases might have a direct and an indirect effect on the number of deaths, the latter being related to the overwhelmed bed capacity of intensive care units. | 2020-05-22 |
| 32426374 | Therefore, in addition to conventional cardiovascular treatment, anti-inflammatory therapy is a reasonable strategy for severe cases to further enhance cardiovascular protection and potentially mitigate MODS. […] We believe that targeting the central pathway (IL-1β, TNF-α, IL-6), balancing the Th1 and Th2 response, and administering long-term anti-inflammatory therapy might be promising prospects to reduce cardiovascular impairment and even MODS during the acute and recovery phases of COVID-19. […] The cardiovascular anti-inflammatory therapies might be of great application value to the management of COVID-19 patients and we further propose an algorithm for the selection of anti-inflammatory therapy for COVID-19 patients with or at high risk of cardiovascular impairment. […] We recommend to take the experiences in cardiovascular anti-inflammatory therapy as references in the management of COVID-19 and conduct related clinical trials, while the clinical translation of novel treatments from preclinical studies or in vitro drug screening should proceed with caution due to unguaranteed efficacy and safety profiles. | 2020-05-22 |
| 32426388 | The narcissoside predicted as more potent inhibitor which can be further optimize, pharmacologically and clinically evaluated for the treatment of novel coronavirus COVID-19. | 2020-05-22 |
| 32426556 | In this article, we focus on recommendations for the surveillance of head and neck cancer patients during and following radiotherapy treatment. | 2020-05-22 |
| 32426749 | Having an understanding of the direct neurotropism of such viruses is imperative to understanding pathogenesis, clinical presentation, and potential treatment paradigms aimed at improving morbidity and mortality. | 2020-05-22 |
| 32426877 | The same drugs are used as adjuvant treatment in disease-free patients. | 2020-05-19 |
| 32426890 | Since the COVID-19 pandemic stormed into the healthcare systems worldwide, protected stroke pathways have been suggested, in order not to spread the viral infection and ensure hyper-acute treatment. | 2020-05-19 |
| 32426897 | Recent reports published in Thrombosis and Haemostasis show that treatment with low-molecular weight heparin (LMWH) decreases mortality in critically ill patients with sepsis-induced hypercoagulation, and thus argue for prophylactic administration of the anticoagulant. […] We would like to use this opportunity to clarify the biochemical background of the diverse activities of heparin, and further, how this information may be exploited to generate more efficient treatment of the viral infection. | 2020-05-19 |
| 32426957 | The paper reviews aspects of COVID-19 that pertain to rheumatology, including symptoms and signs akin to those observed in rheumatic disorders, risk of infection or severe course of the disease in patients with a pre-existing rheumatic disease and those receiving antirheumatic or immunosuppressive medication as well as potential applications of antirheumatic or anticytokine therapeutic strategies that are already applied in rheumatology (including chloroquine, hydroxychloroquine, tocilizumab, baricitinib, and others) for patients with COVID-19. | 2020-05-19 |
| 32427000 | Medication use: 51.1% Western medicine, 32.1% Chinese medicine, 10.7% blood related product, and 6.1% non-drug therapy. | 2020-05-19 |
| 32427134 | It appears that around one third of COVID-19 patients admitted to intensive care units (ICU) for respiratory difficulties exhibit neurologic symptoms. | 2020-05-22 |
| 32427166 | One of the many questions with respect to controlling the novel coronavirus pandemic is whether existing drugs can be re-purposed (re-positioned) for the prevention or treatment of Covid-19 - or for any future epidemic. […] Proposed here is a new but simple concept that would capitalize on the opportunity presented by the on-going natural experiment involving the collection of data from epidemiological surveillance screening and diagnostic testing for clinical treatment. | 2020-05-22 |
| 32427171 |
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2020-05-22 |
| 32427173 | Given this potential, it is imperative that emergency clinicians understand the preliminary data behind the dynamics of this disease, recognize possible presentations of patients, and understand proposed treatment modalities. | 2020-05-22 |
| 32427192 | The treatment of patients with community-acquired pneumonia (CAP), including SARS-CoV‑2 infections, should continue to be based on evidence-based CAP guidelines during the pandemic. […] The treatment of patients with chronic lung diseases must be adapted during the pandemic, but must still be guaranteed. | 2020-05-22 |
| 32427206 | The study deals with the statistical comparison and visualization of country-based real-data for the period December 31, 2019, up to April 12, 2020, and does not intend to address the medical treatment of the disease. | 2020-05-22 |
| 32427279 | There is no proven antiviral or immunomodulatory therapy for COVID-19. […] The disease progression associated with the pro-inflammatory host response prompted us to examine the role of early corticosteroid therapy in patients with moderate to severe COVID-19. […] This treatment effect was observed within each individual component of the composite endpoint. | 2020-05-19 |
| 32427361 | These HIV infected patients were compliant with their HIV medication regimen and had robust CD4 T cell counts. | 2020-05-19 |
| 32427613 | Extracorporeal membrane oxygenation might be an effective salvage treatment for patients with severe acute respiratory syndrome coronavirus 2 pneumonia associated with severe acute respiratory distress syndrome. | 2020-05-19 |
| 32427632 | Various healthcare systems have been forced to postpone treatment for many urological conditions as resources are dedicated to the treatment of COVID-19. | 2020-05-29 |
| 32427773 | Here we report a case series of five patients suffering from profound, medically refractory COVID-19 associated respiratory failure who were treated with fibrinolytic therapy using tissue plasminogen activator (tPA, Alteplase). | 2020-05-19 |
| 32427774 | All patients received protocol directed thrombolytic therapy with Tissue Plasminogen Activator (tPA). […] All five patients improved without deleterious effects of thrombolytic therapy. […] Ventilator support was weaned immediately on post-treatment day 1 and he was extubated on post treatment day 12. […] Our second through fifth patients were not intubated at time of initiation of tPA therapy. […] After tPA therapy, all patients demonstrated a noticeable increase in PaO2 values overtime. […] Clinical trials of thrombolytic therapy would further serve to underscore the efficacy and utility of this therapy. | 2020-05-26 |
| 32428072 | In response to the accelerated increase in the number of COVID-19 cases, countries must increase their supply of beds in intensive care units (ICUs). | 2020-05-26 |
| 32428144 | In severe cases, the use of medications such as hydroxychloroquine and azithromycin or medication can be promising. | 2020-05-22 |
| 32428242 | If we embrace the challenges that will emerge in the post-pandemic environment, the treatment delivered to patients could be more cost effective and better tailored than before. | 2020-05-19 |
| 32428245 | Together, these actions have enabled treatment of all those needing hospital care for COVID-19 and avoided the unfettered increase in mortality that would have accompanied an overwhelmed healthcare service. | 2020-05-19 |
| 32428290 | This article presents a case of a pregnant woman from Wuhan infected with SARS-CoV-2, including her symptoms, pregnancy outcome, and treatment strategy. | 2020-05-23 |
| 32428372 | Until an effective treatment or a vaccine is developed, the current recommendations are to contain the disease, and control its transmission. […] By virtue of the nature of the practice of dentistry where intrinsically, a high volume of aerosols are produced, as well as the close proximity of dentists and patients during treatment, dentists and allied health staff are considered the highest risk health professional group for acquiring SARS-CoV-2 during patient management. | 2020-05-19 |
| 32428379 | The quest for the effective treatment against COVID-19 pneumonia caused by the SARS-CoV-2 coronavirus is hampered by the lack of knowledge concerning the basic cell biology of the infection. | 2020-05-19 |
| 32428835 | This review aimed to provide assistance for the prevention and treatment of COVID-19. | 2020-05-25 |
| 32428865 | In absence of any effective treatment for SARS-CoV-2 infection (COVID-19), remdesivir has been tried for a compassionate use in severe COVID-19. | 2020-05-27 |
| 32428909 | Due to the exponential growth of the number of subjects affected by coronavirus disease 2019 (COVID-19), the entire Italian health care system had to respond promptly and in a very short time with the need of semi-intensive and intensive care units. […] The presentation of this paper is the result of a consensus promoted by the Italian societies of respiratory health care professionals who contacted pulmonologists directly involved in the treatment and rehabilitation of COVID-19. […] Two main areas of intervention were identified: organization and treatment, which are described in this paper to face the emergency. | 2020-05-19 |
| 32428957 | Intubation and mechanical ventilation of the male patient with prolonged intenive care treatment. […] Recovery of the female patient under conventional oxygen therapy. | 2020-05-22 |
| 32429099 | PLP inhibitors have been evaluated during past coronavirus epidemics, and have showed promising results as an antiviral therapy in vitro. […] In this review, we recapitulate the roles of PLPs in coronavirus infections, report a list of PLP inhibitors and suggest possible therapeutic strategies for COVID-19 treatment, using both clinical and preclinical drugs. | 2020-05-21 |
| 32429249 | This is a subjective analysis of literature concerning specific topics raised in our daily practice (e.g., clinical features of COVID-19 patients; ventilation of the critically ill COVID-19 patient; diagnostic of infection with SARS-CoV-2; stability of the virus; Covid-19 in specific patient populations, e.g., paediatrics, immunosuppressed patients, patients with hypertension, diabetes mellitus, kidney or liver disease; co-medication with non-steroidal anti-inflammatory drugs (NSAIDs); antiviral treatment) and we believe that these answers help colleagues in clinical decision-making. […] With ongoing treatment of severely ill COVID-19 patients other questions will come up. | 2020-05-20 |
| 32429580 | Remdesivir is a nucleotide prodrug that is currently undergoing extensive clinical trials for the treatment of COVID-19. | 2020-05-21 |
| 32429774 | These patients are commonly treated with anticoagulation and/or antiplatelet medications and less commonly thrombolysis during hospitalization, potentially with great benefit but management of these medications can be difficult in potentially critically ill patients.In this paper, we review the current guidelines, consensus statements, and emerging evidence for a wide range of cardiovascular disease states with special focus on anticoagulant and antiplatelet therapy. […] Our goal is to provide guidance for treatment of the cardiovascular patient with COVID-19 in the face of a rapidly evolving understanding of this virus and its complications.Preamble:Anticoagulant and antiplatelet therapies are a major cause of inpatient morbidity and mortality. […] In an effort to align practice patterns across a large health system (Jefferson Health 2,622 staffed inpatient beds and 319 intensive care unit (ICU) beds across 14 facilities), a task force was assembled to address the utilization of anti-thrombotic and anti-platelet therapy in COVID-19 positive or suspected patients. […] Our deliberations and treatment recommendations are summarized here.Objective:To provide guidance to the utilization of antithrombotic and antiplatelet therapies in patients with known or suspected COVID-19. | 2020-05-20 |
| 32430286 | They have also been proposed for the treatment of several viral infections, due to their anti-viral effects in cell cultures and animal models, and, currently, for the treatment of coronavirus disease 2019 (COVID-19), the pandemic severe acute respiratory syndrome caused by coronavirus 2 (Sars-Cov-2) infection that is spreading all over the world. […] Although in some recent studies a clinical improvement in COVID-19 patients has been observed, the clinical efficacy of CQ and HCQ in COVID-19 has yet to be proven with randomized controlled studies, many of which are currently ongoing, also considering pharmacokinetics, optimal dosing regimen, therapeutic level and duration of treatment and taking into account patients with different severity degrees of disease. […] Here we review what is currently known on the mechanisms of action of CQ and HCQ as anti-viral, anti-inflammatory and anti-thrombotic drugs and discuss the up-to-date experimental evidence on the potential mechanisms of action of CQ/HCQ in Sars-Cov2 infection and the current clinical knowledge on their efficacy in the treatment of COVID-19 patients. | 2020-05-31 |
| 32430428 | The duration of viral shedding is central to guide the decisions of isolation precautions and antiviral treatment. […] However, studies regarding the risk factors associated with prolonged SARS-CoV-2 shedding and the impact of Lopinavir/Ritonavir (LPV/r) treatment on viral shedding remain scarce. […] We compared clinical characteristics and SARS-CoV-2 RNA shedding between patients initiated with LPV/r treatment and those without. […] Of 120 patients, the median age was 52 years, 54 (45%) were male and 78 (65%) received LPV/r treatment. […] Older age (odd ratio [OR] 1.03, 95% confidence interval [CI] 1.00-1.05, p=0.03) and the lack of LPV/r treatment (OR 2.42, 95% CI 1.10-5.36, p=0.029) were independent risk factors of prolonged SARS-CoV-2 RNA shedding. […] Patients who initiated LPV/r treatment within 10 days from symptom onset, but not initiated from day 11 onwards, had significantly shorter viral shedding duration compared with those without LPV/r treatment (median 19 days versus 28.5 days, Log-rank p<0.001). […] Older age and the lack of LPV/r treatment were independently associated with prolonged SARS-CoV-2 RNA shedding in patients with COVID-19. […] Earlier administration of LPV/r treatment could shorten viral shedding duration. | 2020-05-20 |
| 32430429 | Timely diagnosis of SARS-CoV-2 infection is a prerequisite for treatment and prevention. | 2020-05-20 |
| 32430456 | Despite that all patients were on standard treatment for Covid-19 infection, IL-6 and D-dimer levels persisted higher in patients with hyperglycemia during hospitalization. | 2020-05-20 |
| 32430617 | In vitro, in vivo, or preliminary trials of these drugs in the treatment of COVID-19 have been encouraging, leading to new research projects and trials to find the best drug/s. […] COVID-19 therapy must be based on expert clinical experience and published literature and guidelines from major health organizations. | 2020-05-23 |
| 32430651 | In clinical practice, angiotensin-converting enzyme inhibitors (ACE-Is) and angiotensin II receptor blockers (ARBs) are extensively used for the treatment of hypertension and other cardiovascular diseases. | 2020-05-23 |
| 32430996 | There is an urgency to understand the mechanism by which this virus causes complications so as to develop treatment options. […] Curcumin, a natural polyphenolic compound, could be a potential treatment option for patients with coronavirus disease. […] This review provides a basis for further research and development of clinical applications of curcumin for the treatment of newly emerged SARS-CoV-2. | 2020-05-20 |
| 32431119 | The implications of the outbreak are similar in many countries, among others, due to the uncertainty regarding the way the virus spreads, the appropriate treatment, the lack of vaccination and the high rate of deaths. | 2020-05-21 |
| 32431134 | Remodelled tasks in charge of RPTs were: oxygen therapy daily monitoring, non invasive ventilation (NIV) and continuous positive airways pressure (CPAP) delivery, pronation and postural changes to improve oxygenation, reconditioning with leg/arm cranking and exercises, initial and final patients’ functional assessment by short-physical performance battery (SPPB) and 1-minute sit-to-stand test (1-STS) to evaluate motor conditions and exercise-induced oxygen desaturation. […] As main topics, RPTs have been involved in oxygen therapy management in almost a third of the admitted patients, reconditioning exercises in 60% of the cases, and initial and final functional motor capacity assessment in all patients. | 2020-05-22 |
| 32431755 | If successful, this therapy may attenuate the cytokine storm observed in these patients and potentially reduce mortality, increase ventilation free days, improve oxygenation parameters and consequently lessen the burden on patients and the intensive care unit. | 2020-05-23 |
| 32431756 | The concept can easily be adopted to other patient care areas, including perioperative and intensive care units. | 2020-05-23 |
| 32431992 | Several alternatives in treatment options have been assessed and used in this patient population. […] While some studies have shown a high mortality rate despite aggressive treatment, such as in our case, the lack of large sample size studies and treatment alternatives places healthcare providers against a wall without options in patients with severe refractory ARDS due to COVID-19. | 2020-05-23 |
| 32432121 | During this study, a total of 173 patients (64.08%) were recovered after treatment. Conclusion: In some epidemiological backgrounds, CT imaging manifestations and evolutionary characteristics are of great significance for early warning of lung injury, assessment of disease severity, and assistance in clinical typing and post-treatment follow-up. | 2020-05-23 |
| 32432127 | Knowledge of these risks will allow informed decisions regarding appropriate therapeutics and monitoring to keep our patients safe. | 2020-05-23 |
| 32432445 | The reasons for this particular susceptibility are to be found in the compromised immune system, secondary to chronic malnutrition, immunosuppressive therapy, and uremia, frequent contact with healthcare personnel and other patients attending the dialysis unit and in need of the presence of other family members during treatment. | 2020-05-20 |
| 32432527 | Hydroxychloroquine (HCQ) has sparked much interest in the therapeutics of the Coronavirus Disease 2019 (COVID-19) pandemic. | 2020-05-20 |
| 32432995 | During the coronavirus disease 2019 (COVID-19) pandemic, infectious disease control is of utmost importance in acute stroke treatment. […] Herein, we are describing our experience with simulation training for COVID-19 stroke treatment protocols. | 2020-05-30 |
| 32432998 | Inpatient stroke pathways and treatment time metrics nevertheless did not differ between the 2 groups (P>0.05 for all comparisons). | 2020-05-30 |
| 32433010 | We urgently need to find treatment and vaccine to stop the epidemic. | 2020-05-20 |
| 32433217 | The review discusses the existing challenges of SARS-CoV-2 diagnostics and the potential application of translational technology for epidemiological predictions, patient monitoring and treatment decision-making in COVID-19. | 2020-05-20 |
| 32433248 | The available technology has several advantages including: a) facilitating appropriate paperless documentation and communication between all healthcare givers working in isolation rooms or large isolation areas; b) testing patients and staff at the bedside using smart point of care diagnostics (SPOCD) to confirm COVID-19 infection; c) allowing diagnostics and treatment at the bedside through point of care ultrasound (POCUS) and Thromboelastography (TEG); d) adapting the use of anaesthetic machines and the use of volatile anaesthetics. | 2020-05-30 |
| 32433291 | : Treatment of the COVID-19 critically ill patient requires oxygenation and ventilation support for prolonged periods which seem unique for viral pneumonia. | 2020-05-20 |
| 32433343 | Without effective treatment and vaccination, the strategies to restrain this disease is only keeping social distance, maintaining personal hygiene, quarantine and isolation. […] However, thrice-a-week treatment is inevitable for all hemodialysis patients. | 2020-05-20 |
| 32433345 | As the SARS-CoV-2 infection pandemic proceeds, many efforts are being dedicated to the development of diverse treatment strategies. | 2020-05-20 |
| 32433363 | In an attempt to reduce preventable harm to individuals with opioid use disorder (OUD), federal, state, and local governments have temporarily modified law and policy to increase access to OUD treatment and divert some individuals at high risk away from the correctional system. […] In this Commentary, we briefly describe how people with OUD are at increased risk for COVID-19, discuss existing policy barriers to evidence-based prevention and treatment for individuals with OUD, explain the temporary rollbacks of those barriers, and argue that these changes should be made permanent. | 2020-05-20 |
| 32433364 | To reduce the spread of coronavirus disease 2019 (COVID-19), many substance use disorder treatment programs have transitioned to telemedicine. […] We describe 2 cases where telemedicine was combined with street outreach to connect patients experiencing homelessness with OUD to treatment. […] These cases highlight an important opportunity to provide access to life-saving OUD treatment for vulnerable patients in the setting of a pandemic that mandates reduced face-to-face clinical interactions. | 2020-05-20 |
| 32434108 | From 23rd February to 31st March 2020, 1257 patients on active anticancer treatment for oncological or haematological malignancies attended our institution. […] In conclusion, following our practical health vigilance recommendations, physicians should be confident in maintaining life-saving anticancer treatment without exceedingly increasing the risk of nosocomial COVID-19 infection. […] The high rate of mortality suggested that all patients on active anticancer treatment with flu-like symptoms have to be carefully screened for COVID-19 infection. | 2020-05-28 |
| 32434211 | High levels of IL-6 and IL-8 during treatment were observed in patients with severe or critical disease and correlated with decreased lymphocyte count. | 2020-05-20 |
| 32434314 | While acute care and intensive care units are the main pillars of the early response to the disease, rehabilitative medicine should play an important part in allowing COVID-19 survivors to reduce disability and optimize the function of acute hospital setting. […] We analyze all these consequences and propose some practical treatment options, based on current evidence and clinical experience, as well as several suggestions for management of rehabilitation services and patients with suspected or confirmed infection by SARS-CoV-2. | 2020-05-21 |
| 32434337 | Current potential treatment options include hydroxychloroquine, remdesivir, lopinavir/ritonavir and convalescent plasma. | 2020-05-26 |
| 32434402 | Globally implementing preventive and controlling measures, and cultivating coping and resilience are challenging factors; modified lifestyle (lockdown curfew, self-isolation, social distancing and quarantine); conspiracy theories, misinformation and disinformation about the origin, scale, signs, symptoms, transmission, prevention and treatment; global socioeconomic crisis; travel restrictions; workplace hazard control; postponement and cancellation of religious, sports, cultural and entertainment events; panic buying and hoarding; incidents of racism, xenophobia, discrimination, stigma, psychological pressure of productivity, marginalization and violence; overwhelmed medical centers and health organizations, and general impact on education, politics, socioeconomic, culture, environment and climate - are some of the risk factors to aggravate further problems. | 2020-05-21 |
| 32434596 | The COVID-19 pandemic has disrupted the traditional practice of psychiatric assessment and treatment via face to face interaction. | 2020-05-21 |
| 32434606 | In ADMiRE, there has been a significant reduction of face to face consultations, postponement of new assessments, difficulties with physical monitoring, delays in medication initiation, suspension of medication titration, lack of group interventions and problems with access to controlled drug prescriptions. | 2020-05-21 |
| 32434611 | These improved outcomes are a result of reducing delays to treatment and the provision of specialized, holistic interventions. […] The covid-19 pandemic poses significant challenges to the delivery of these services, such as undetected cases or long delays to treatment. | 2020-05-21 |
| 32434627 | A cornerstone of therapy is the work in the community through further education and community organisations. | 2020-05-21 |
| 32434632 | The National Emergency Medical Rescue Team of the Second Xiangya Hospital of Central South University, together with other 13 medical teams (841 medical staff in total), have fulfilled the task for the treatment of non-severe COVID-19 patients, without any medical staff infected. | 2020-05-26 |
| 32434634 | All 23 children received antiviral therapy and were recovered. | 2020-05-26 |
| 32434635 | This article reports the diagnosis and treatment of two children with coronavirus disease 2019 (COVID-19) and hypertension. | 2020-05-26 |
| 32434728 | The adjusted model focused on comprehensive and rapid acute stroke treatment, reduction of exposure to the healthcare team, and preservation of PPE. | 2020-05-23 |
| 32434788 | To date, there is no effective treatment. | 2020-05-29 |
| 32434789 | The impact of ICI therapy on the severity of acute coronavirus infection symptomatology warrants further exploration. […] Although we do not have data on the impact of ICI therapy on severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) symptomatology, a possible interaction should be considered when deciding on dosing in patients with possible SARS-CoV-2 exposure or when evaluating patients with presumed ICI-related pneumonitis during the COVID-19 pandemic. | 2020-05-29 |
| 32434790 | One important clinical question is how to manage patients who need anticancer therapy, including immune checkpoint inhibitors (ICIs) during these conditions. […] In particular, we consider the impact of ICI on COVID-19 severity, decisions surrounding continuing or interrupting therapy, diagnostic measures in patients with symptoms or manifestations potentially consistent with either COVID-19 or ICI toxicity, and resumption of therapy in infected patients. | 2020-05-29 |
| 32434798 | Based on a multi-institutional collaborative effort, we describe best practices when providing neurosurgical treatment for patients with covid-19 in order to optimize clinical care and minimize the exposure of patients and staff. | 2020-05-21 |
| 32434805 | Specific recommendations by national organizations and institution specific step-by-step guidelines and education materials are required to maintain safety for both patients and caregivers perioperatively, with transport, and medication management. | 2020-05-21 |
| 32435065 | In about 20% of patients, severe symptoms occur after a mean incubation period of 5 - 6 days; 5% of patients need intensive care therapy. […] Therapy is based on established recommendations issued for patients with acute lung injury (ARDS). […] Lung protective ventilation, prone position, restrictive fluid management and adequate management of organ failure are the mainstays of therapy. | 2020-05-23 |
| 32435268 | Many concerns have arisen about the management and treatment of children with cancer while researchers are wondering how to deal with this devastating pandemic. | 2020-05-23 |
| 32435272 | A total of 8 patients received combined therapy of traditional Chinese medicines and western medicines. […] From the clinical outcomes of these 8 patients, western combined therapy of traditional Chinese medicine was indeed an effective treatment method. […] D-dimmer rise, infection index rise, and chest CT(computed tomography) progression may be clinical warning indicators for severe patients, in our study, more 50% of patients had elevated levels of these indicators, but only 44% (including the dead) of patients had received treatment in the intensive care unit. 5 (56%) ordinary type patients had been discharged, while the 1 (11%) critical type patient died 3 days after admission. […] Cancer comorbidity seems to have no direct relationship with severe events, and the combination of traditional Chinese medicine and western medicine may be effective in the prevention and treatment of novel coronavirus-infected pneumonia (NICP). | 2020-05-23 |
| 32435607 | Unfortunately, there is no specific prevention and treatment strategy for this disease. | 2020-05-23 |
| 32435867 | Glycemic control during infectious diseases is often suboptimal, and antidiabetic drugs and insulin therapy have to be adapted accordingly. […] On the other hand, access of diabetes patients to outpatient clinics are limited during the ongoing season urging alternative treatment options, particularly the implementation of novel telemedicine strategies. | 2020-05-23 |
| 32435870 | Currently, treatment is supportive. | 2020-05-23 |
| 32435879 | None required oxygen therapy, and 7 could be managed as outpatients. | 2020-05-23 |
| 32435882 | Our objective was to show that indomethacin could be considered as a promising candidate for the treatment of SARS-CoV-2 and to provide criteria for comparing benefits of alternative dosage regimens using a model-based approach. […] The treatment with the SR formulation at the dose of 75 mg twice-a-day is expected to achieve a complete response in three days for the treatment in patients infected by the SARS-CoV-2 coronavirus. […] These results suggest that indomethacin could be considered as a promising candidate for the treatment of SARS-CoV-2 whose potential therapeutic effect need to be further assessed in a prospective clinical trial. | 2020-05-23 |
| 32435920 | Since its introduction in modern medicine, naturalistic observations emerged about possible uses of lithium treatment for conditions different from recurring affective disorders, for which it is still a first-line treatment option. […] In fact, treatment with lithium requires continuous monitoring of its serum levels in order to prevent acute toxicity and long-term side effects, most notably affecting the kidney and thyroid. | 2020-05-23 |
| 32436016 | Two-thirds of the centers were involved in the treatment of COVID19 cases. […] Intensive care units (ICU) beds were partially or totally reallocated for the treatment of COVID19 cases in 72% of the hospitals. […] A significant reduction of the number of colorectal resections during the time span from January to March 2020 was recorded, with significant delay in treatment in more than 50% of the centers. | 2020-05-22 |
| 32436029 | While there is no specific recommended treatment for COVID-19, nitric oxide has the potential to be of therapeutic value for managing acute respiratory distress syndrome in patients with COVID-19. […] Given the extent of the COVID-19 pandemic, and the large numbers of hospitalized patients requiring respiratory support, clinical use of inhaled nitric oxide may become an alternate rescue therapy before extracorporeal membrane oxygenation for the management of acute respiratory distress syndrome in patients with COVID-19. | 2020-05-23 |
| 32436445 | Convalescent blood products are the most promising potential treatment for use in COVID-19. | 2020-05-22 |
| 32436581 | The severe acute respiratory syndrome coronavirus 2 (SARS-CoV2) pandemic is causing an increased need for mechanical ventilation for a significant percentage of people who present to the hospital for treatment. | 2020-05-21 |
| 32436994 | Mean (SD) levels of c-reactive protein (CRP) were significantly decreased following treatment 24.6 (26.9) mg/L compared to baseline 140.4 (77) mg/L (P< 0.0001). […] Ongoing randomized control trials will allow for further evaluation of this promising therapy. | 2020-05-21 |
| 32437000 | A 34 year old HIV-positive female on antiretroviral therapy (tenofovir disoproxil fumarate, lamivudine and efavirenz) for 5 years, tested positive for SARS-CoV-2, the causative agent for coronavirus disease 19 (COVID-19). | 2020-05-21 |
| 32437004 | SARS-CoV-2 can cause liver injury through systemic inflammatory response syndrome (SIRS), cytokine storms, ischemia-reperfusion injury, side effects of treatment drugs, and underlying liver disease and can attack liver cells directly via ACE2. […] Liver injury may be a risk factor for progresses and worsens in patients with COVID-19, and it is necessary to pay attention to the occurrence of liver injury in the diagnosis and treatment of COVID-19. | 2020-05-21 |
| 32437014 | Ozone may exert its antiviral actions and ozone therapy has been demonstrated therapeutically usefulness in influenza and novel viruses. […] In this letter, two severe cases with COVID-19 received ozone therapy were described. […] The results showed that ozone therapy may promote recovery of clinical condition and improvement of chest CT images, shorten the duration of viral shedding and length of hospital stay. | 2020-05-21 |
| 32437017 | All 18 patients were eventually discharged, including the 3 severe patients who recovered after treatment with non-invasive mechanical ventilation, convalescent plasma and other therapies. | 2020-05-21 |
| 32437019 | Currently, there are no approved therapies for the treatment of COVID-19. […] With most of the world on lockdown and the looming threat of millions of deaths, there is immense pressure to find a therapy for this disease. | 2020-05-21 |
| 32437024 | 1,2) Unfortunately, even after six months since its first detection, we still do not have any definitive treatment options for COVID-19 pneumonia. | 2020-05-21 |
| 32437032 | While no single management algorithm for head and neck cancer can be universally implemented, a detailed examination of these issues is necessary to formulate ethically sound treatment strategies. | 2020-05-21 |
| 32437052 | Monitoring case fatality in Belgium, the Netherlands and Sweden, and treatment successes in Germany and Austria play an utmost importance. | 2020-05-21 |
| 32437381 | COVID-19 discussions often focus on intensive care units in hospitals. | 2020-05-28 |
| 32437675 | This report shows feasibility for surgical treatment of acute aortic disease in patients with COVID-19. | 2020-05-23 |
| 32437696 | Whether a mobile cabin hospital can provide a safe treatment site for patients with mild COVID-19 symptoms remains unknown. […] Mobile cabin hospitals provide a safe treatment site for patients with mild COVID-19 symptoms, and provide an effective isolation area to prevent the spread of SARS-CoV-2. | 2020-05-23 |
| 32437739 | This pilot study provides the first evidence of the safety of anti-IL-1 treatment with highdose IV anakinra in 5 patients, who experienced a positive outcome. | 2020-05-23 |
| 32437770 | Unfortunately, there is lack of evidence about the optimal management of novel coronavirus disease 2019 (COVID-19), even less in patients on maintenance hemodialysis (MHD) therapy than in the general population. […] Among the 36 patients, 18 had worsening of their clinical status, as defined by severe hypoxia with oxygen therapy requirements greater than 4 Liters/minute and radiological worsening. | 2020-05-23 |
| 32437797 | Furthermore, we focused on possible therapeutic options such as repurposing drugs including antimalarials, antivirals, antiparasitic drugs, and anti-HIV drugs, as well as monoclonal antibodies, vaccines as potential treatment options. […] Also we have summarized the latest research progress on the usage of stem cell therapy, human convalescent serum, interferon’s, in the treatment of COVID-19. | 2020-05-23 |
| 32437820 | We opine that one of these treatment options is low dose radiation therapy for severe and most critical cases. | 2020-05-23 |
| 32437934 | Relevant inflammatory cytokine storm is associated with severity of disease and IL1 inhibition is a cornerstone treatment for hyperinflammatory diseases. | 2020-05-23 |
| 32437942 | Comprehensive palliative care should be an explicit part of both national and global COVID-19 response plans. […] Therefore, we aimed to identify, review and compare national and international COVID-19 guidance for nursing homes concerning palliative care, issued by government bodies and professional associations. […] We identified 21 eligible documents covering both nursing homes and palliative care; from the World Health Organization (n=3), and eight individual countries: USA (n=7), the Netherlands (n=2), Ireland (n=1), United Kingdom (n=3), Switzerland (n=3), New Zealand (n=1), Belgium (n=1). […] International documents focused primarily on infection prevention and control, including only a few sentences on palliative care related topics. […] Palliative care themes most frequently mentioned across documents were end-of-life visits, advance care planning documentation, and clinical decision-making towards the end of life (focusing on hospital transfers). […] There is a dearth of comprehensive international COVID-19 guidance on palliative care for nursing homes. […] Key aspects of palliative care, i.e. symptom management, staff education and support, referral to specialist services or hospice, and family support, need greater attention in future guidelines. | 2020-05-23 |
| 32437946 | Lesbian, gay, bisexual, transgender, gender-nonconforming, and queer/questioning-identified (LGBTQ+) persons are particularly vulnerable to health inequities across settings, including palliative care and at the end of life. […] There is a crucial gap in the literature pertaining to palliative care for LGBTQ+ populations during COVID-19. | 2020-05-30 |
| 32438018 | Daily ECG monitoring and other risk mitigation strategies should be considered in order to prevent possible harms from what is currently an unproven therapy. | 2020-05-23 |
| 32438240 | One of the most disturbing issues is Covid-19 treatment; although a large number of medications, previously used successfully with other viruses (including Chinese herbal medicines and anti-malaria drugs), are under consideration, there remain questions as to whether they can play a satisfactory role for this disease. […] Global attempts are ongoing to find the drugs for the treatment of this virus but none of the antiviral drugs used for treatment of other human viral infection is working and hence attempts to find new drugs are continuing. | 2020-05-26 |
| 32438256 | Still, clinicians should combine radiology and laboratory methods to achieve a higher detection rate, so that instant isolation and treatment could be effectively conducted to curb the rampant spread of the epidemic. | 2020-05-29 |
| 32438328 | This systematic review highlights a particularly vulnerable group - obese, and emphasises on the importance of treatment aggression and disease prevention in this population group. | 2020-05-27 |
| 32438329 | VR is beneficial for remote sites for exploring telemedicine, planning, treatment, and controlling of the infections by providing proper awareness to the people regarding this disease. | 2020-05-27 |
| 32438330 | As on date, no specific treatment is available for devastating COVID-19 (SARS-CoV-2) infection. […] As per WHO guidelines, the treatment is mainly symptomatic and supportive. […] This clinical protocol has not proven sufficient to save the lives of COVID-19 patients suffering from diabetes or having underlying liver diseases; hence there is utmost need to tackle this situation by other means such as Convalescent Plasma (CP) therapy. […] The CP therapy can be a possible life saving alternative to treat critical COVID-19 patients having diabetes or underlying liver dysfunction. | 2020-05-27 |
| 32438333 | The intermingled effects of diabetes with other cardiovascular comorbidities warrant age-specific outcomes data including the impact of ongoing antidiabetic treatment. | 2020-05-27 |
| 32438340 | The withdrawal of ATDs and urgent measurement of neutrophils should be considered in case of flu-like manifestations occurring in the initial months of treatment. […] Patients who are on replacement treatment with thyroid hormones should ensure they have sufficient supply of medication. | 2020-05-21 |
| 32438345 | Most patients with thyroid nodules and thyroid cancer (TC) referred for diagnostic work-up and treatment are not considered at higher risk of infection from SARS-CoV-2 compared to the general population. […] Accordingly, diagnostic work-up of thyroid nodules, thyroid surgery for either benign or malignant thyroid nodules and radioiodine treatment for differentiated thyroid cancers may be safely postponed during SARS-CoV-2 pandemic. […] Appropriate patient counselling, however, is mandatory and red flags should be carefully identified prompting immediate evaluation and treatment as appropriate. […] For these selected cases diagnostic work-up (e.g. ultrasound, scintigraphy, fine-needle aspiration), surgery and radioiodine therapy may proceed despite the threat of SARS-CoV-2 infection and COVID-19, after an individual risk-benefit analysis. | 2020-05-21 |
| 32438371 | Our results enable a detailed analysis of the inhibitory mechanisms that underlie the antiviral activity of substances such as remdesivir, a drug for the treatment of coronavirus disease 2019 (COVID-19)4. | 2020-05-21 |
| 32438382 | How can we learn from the COVID-19 situation to deliver treatment to individuals who may have difficulties attending traditional clinic-based care, such as those in more rural areas with transport difficulties? | 2020-05-28 |
| 32438383 | There is currently no proven treatment for COVID-19 and a safe and effective vaccine is at least a year away. […] The receptor binding domain (RBD) of the virus is unlikely to mutate without loss of pathogenicity and thus represents an attractive target for antiviral treatment. | 2020-05-28 |
| 32438446 | There is a rapidly expanding literature on the in vitro antiviral activity of drugs that may be repurposed for therapy or chemoprophylaxis against SARS-CoV-2. | 2020-05-21 |
| 32438454 | Currently, a clear relationship between COVID-19 infection incidence and/or complications due to chronic or occasional treatments for other pathologies is still not clear, albeit COVID-19 pandemic may condition the treatment strategy of complex disorders, as osteoarthritis (OA). | 2020-05-21 |
| 32438459 | This has created an urgent need to identify effective medications for its prevention and treatment (1). | 2020-05-21 |
| 32438464 | We reviewed three reported cases with detailed treatment information from China to better understand the features and associated therapeutic strategies used in transplant recipients with COVID-19.2-4. | 2020-05-21 |
| 32438617 | The indications for renal replacement therapy for these patients are those commonly accepted to treat AKI. […] We describe a continuous veno-venous haemodialysis (CVVHD) protocol for AKI, which aims to provide the best treatment according to the particular patient’s and medical personnels’ needs in biohazard settings with limited human and technological resources. | 2020-05-22 |
| 32438703 | Thus, special considerations should be taken to prevent infection of older cancer patients and to provide them with adequate social support during their cancer treatment. […] (8) For selected patients, immunotherapy and targeted therapy may become the systemic therapy of choice for older cancer patients and need to be tested in clinical trials. | 2020-05-22 |
| 32438763 | Anemia is a frequent manifestation in patients with chronic inflammatory bowel disease (IBD) and requires tight monitoring and adequate supplementary therapy. […] Intravenous iron is the first-line treatment in subjects with moderate-severe anemia, active disease, or oral iron intolerance. […] Oral iron, including both the traditional formulations with ferrous iron and the new ferric iron complexes, could constitute a valid alternative for anemia treatment. […] For this reason, we conducted a literature review, to summarize the scientific evidence on oral iron therapy in IBD patients with anemia. | 2020-05-22 |
| 32438839 | This manuscript reviews the different aspects of blood purification in critically ill patients with AKI and increased inflammatory factors, and examines its potential role in severe COVID-19 treatment. […] Continuous renal replacement therapy (CRRT) has been practiced in many sepsis patients with AKI. […] Their potential in removing inflammatory factors and other toxins prospects for the treatment of severe COVID-19. | 2020-05-22 |
| 32438878 | However, access to the hospital for therapy or for unstable/relapsing patients was not considered postponable. […] At the entrance of the therapy area, a control station was set up in order to double-check all patients with a clinical interview and conduct thermal scanning. […] A total of 1451 IBD patients under biotechnological or experimental therapy actively followed in the CEMAD IBD centre were included in the study. […] About 10% of patients receiving subcutaneous therapy were allowed to collect their medicine without a follow-up visit. […] Finally, 10% of patients living outside the Lazio region requested access to their therapy at a local centre closer to their home. | 2020-05-22 |
| 32439198 | Scientist, doctors are searching for effective therapy of this diseases. […] The remdesivir, an antiviral drug, is appeared as ‘molecule of hope’ for the treatment of this disease. […] USFDA approve this drug for the treatment of COVID-19. | 2020-05-24 |
| 32439237 | Transplanted patients have to receive immunosuppressive therapy to prevent rejection. […] Management of immunosuppressive therapy and drug-drug interactions in liver transplant recipients infected with COVID-19 should be cautiously practiced to prevent rejection and effectively treat the underlying infection. | 2020-05-25 |
| 32439366 | Hydroxychloroquine and azithromycin combination therapy is often prescribed for coronavirus disease 2019 (COVID-19). […] We performed 12‑lead ECGs and 12‑lead 24-h Holter ECG monitoring in all patients aged <80 years admitted to our medical unit for COVID-19, in oral therapy with hydroxychloroquine (200 mg, twice daily) and azithromycin (500 mg, once daily) for at least 3 days. […] ECG after therapy showed longer QTc-interval than before therapy (450 vs 426 ms, p = .02). […] Therapy with hydroxychloroquine and azithromycin prolongs QTc interval in patients with COVID-19, particularly in those with high levels of transaminases. | 2020-05-26 |
| 32439516 | Given the significant overlap between the core tenets of TIC and accepted guidelines for the provision of quality palliative care (PC), PC teams are particularly well poised to both incorporate such practices into routine care and to argue for their integration across health systems. | 2020-05-25 |
| 32439650 | Thrombectomy for large-vessel-occlusion stroke is a highly impactful treatment. | 2020-05-22 |
| 32439821 | Further investigation is required to clarify the full clinical spectrum of neurologic symptoms and its optimal treatment. | 2020-05-22 |
| 32440386 | Patients with potentially curable cancers are at risk of not receiving timely SOC multidisciplinary treatments, such as surgery, chemotherapy, radiation therapy, or combination treatments. […] Additionally, ambulatory efforts to avoid treatment-related morbidity are critical for keeping patients out of emergency departments and hospitals. […] In this review article, we discuss evidence-based radiation therapy approaches for curable cancer patients during the COVID-19 pandemic. […] We focus on three scenarios of cancer care: 1) radiation therapy as an alternative to surgery when immediate surgery is not possible, 2) radiation therapy as a ‘bridge’ to surgery, and 3) radiation options definitively or postoperatively, given the risk of hospitalization with high-dose chemotherapy. | 2020-05-25 |
| 32440661 | We should pay special attention to early diagnosis and early treatment in children infected with COVID-19. | 2020-05-25 |
| 32440662 | In this paper, we review the literature about the common treatment of pemphigus with a focus on the lessons from similar epidemics to find a proper suggestion to manage pemphigus in the COVID-19 pandemic era. […] The effect of many of the drugs used for treatment of Pemphigus vulgaris (PV) on COVID-19 is not clear. | 2020-05-25 |
| 32440883 | We discuss in-hospital and post-discharge venous thromboembolism (VTE) prevention, treatment of suspected but unconfirmed VTE, laboratory monitoring of COVID-19, associated anticoagulant therapies, and essential elements for optimized transitions of care specific to patients with COVID-19. | 2020-05-25 |
| 32441196 | In many countries the exponential growth of Covid-19 cases is overwhelming health care systems with overcrowding of hospitals and overflowing Intensive Care Units. | 2020-05-22 |
| 32441232 | Recognizing the dynamic nature of COVID-19, the protocol addresses the potential investigational treatment options and considerations for special populations. | 2020-05-22 |
| 32441332 | Demographic data, clinical findings, laboratory test results, imaging findings, treatment received, and outcomes were collected. […] Forty-one patients (68.6%) required hospital admission (18 due to disease worsening and 23 for delivery) of whom 21 patients (35%) underwent pharmacological treatment, including hydroxychloroquine, antivirals, antibiotics and tocilizumab. | 2020-05-22 |
| 32441462 | The global response to finding therapeutics for COVID-19 is chaotic even if well intentioned. […] There is an opportunity, but more importantly, an obligation for the global clinical and quantitative pharmacology community to come together and use our state-of-the-art tools and expertise to help society accelerate therapeutics to fight COVID-19. | 2020-05-22 |
| 32441764 | Clinically approved PARP inhibitors (PARPi) have a mild adverse effect profile and are well-tolerated as continuous daily oral therapy. […] PARPi’s may potentiate the effectiveness of Tocilizumab, Anakinra, Sarilumab, Adalimumab, Canakinumab or Siltuximab therapy. […] In summary, the evidence suggests that PARPi therapy would benefit COVID-19 patients and trials of these drugs should be undertaken. | 2020-05-22 |
| 32441771 | Several trials are currently underway evaluating the antimalarial drug hydroxychloroquine as a potential treatment for acute infection. […] Next, we identified medications that were flagged by MedSafer as being potentially inappropriate and crafted guidance around medication management if contemplating the use of hydroxychloroquine. […] The COVID-19 pandemic highlights the importance of medication optimization and deprescribing PIMs in older adults. […] By acting now to reduce polypharmacy and use of PIMs, we can better prepare this vulnerable population for inclusion in trials and, if substantiated, pharmacologic treatment or prevention of COVID-19. | 2020-05-22 |
| 32441773 | Previous reports suggest the possibility of a protective factor from standard antiretroviral treatment for HIV patients that could have significant clinical benefits for these patients when co-infected with SARS-CoV-2. | 2020-05-22 |
| 32441783 | Severe pneumonia which shares several of the features of acute respiratory distress syndrome (ARDS) is the main cause of morbidity and mortality in Coronavirus disease 19 (Covid-19) for which as of now there is no effective treatment. | 2020-05-22 |
| 32441786 | In our retrospective non-randomised study, 34 patients under 50 years old and diagnosed with coronavirus disease 2019 (COVID-19) were included, according to given methylprednisolone treatment (n = 18) or not (n = 16), they were separated into 2 groups. […] By comparing the clinical data we concluded that corticosteroids therapy can effectively release COVID-19 symptoms such as persistent fever and difficult breathing, improve oxygenation and prevent disease progression. | 2020-05-22 |
| 32441787 | Here, a patient with immune thrombocytopenic purpura in Huoshenshan Hospital (Wuhan, China) was reported, whose laboratory data, clinical treatment and hospital outcome was described in this study. | 2020-05-22 |
| 32441788 | Many critically ill patients with COVID-19 need specialty level palliative care to manage symptoms, conduct goals of care conversations, and facilitate medical decision making in ethically and emotionally charged situations. […] During the apex of the COVID-19 crisis in New York, the Adult Palliative Care Service at Columbia University Irving Medical Center (CUIMC)/NewYork-Presbyterian (NYP) received a 7-fold increase in consultation requests. […] This unprecedented increase in demand outpaced the palliative care team’s ability to respond. […] We describe the rapid development and implementation of a scalable virtual consultation model staffed by out-of-state palliative care specialist volunteers. | 2020-05-22 |
| 32441805 | Today, it is a pandemic infection, and even if several compounds are used as curative or supportive treatment, there is not a definitive treatment. […] In particular, antiviral treatment used for the treatment of several viral infections (eg, hepatitis C, HIV, Ebola, severe acute respiratory syndrome-coronavirus) are today used with a mild or moderate effect on the lung injury. […] Therefore, an add-on therapy with drugs able to reduce inflammation, edema, and cell activation has been proposed as well as a treatment with interferon, corticosteroids or monoclonal antibodies (eg, tocilizumab). […] In this article reviewing literature data related to the use of escin, an agent having potent anti-inflammatory and anti-viral effects in lung injury, we suggest that it could represent a therapeutic opportunity as add-on therapy in ALI related to COVID-19 infection. | 2020-05-22 |
| 32442035 | Two systematic reviews suggest a large reduction in mortality with NIV compared with conventional oxygen therapy. | 2020-05-27 |
| 32442105 | Treatment of cells with auranofin resulted in a 95% reduction in the viral RNA at 48 h after infection. […] Auranofin treatment dramatically reduced the expression of SARS-COV-2-induced cytokines in human cells. | 2020-05-25 |
| 32442210 | There is currently no specific treatment for COVID-19, but antiviral therapy combined with supportive care is the main strategy. […] Here, we summarize recent progress in understanding the epidemiological, virological, and clinical characteristics of COVID-19 and discuss potential targets with existing drugs for the treatment of this emerging zoonotic disease. | 2020-05-28 |
| 32442265 | Studies of the impact of treatment on asymptomatic RT-PCR+ individuals on disease progression and transmission should be undertaken. | 2020-05-22 |
| 32442285 | No significant differences were observed between RAAS inhibitor users and nonusers in terms of vasopressor use, modes of ventilation, extracorporeal membrane oxygenation, renal replacement therapy, and acute cardiac events. | 2020-05-22 |
| 32442287 | Thymosin alpha 1 (Tα1) had been used in the treatment of viral infections as an immune response modifier for many years. […] Compared with untreated group, Tα1 treatment significantly reduces mortality of severe COVID-19 patients (11.11% vs. | 2020-05-22 |
| 32442315 | ACE2 is a potential target for many treatment approaches for the SARS-CoV-2. | 2020-05-29 |
| 32442317 | Paradoxically, treatment with anti-inflammatory agents and immune regulators has been associated with worsening of ARDS. | 2020-05-22 |
| 32442347 | Where mechanical ventilation may not be enough, extracorporeal membrane oxygenation (ECMO) could play a role as a form of rescue therapy and may provide beneficial results in the hands of skilled clinicians in centers with experience of using ECMO appropriately in selected patients. | 2020-05-22 |
| 32442437 | Thereafter, two other proteasome inhibitors (carfilzomib and ixazomib), designed to overcome resistance to bortezomib, have been approved for treatment-experienced patients, and a variety of novel inhibitors are currently under preclinical and clinical investigation not only for haematological malignancies but also for solid tumours. | 2020-05-25 |
| 32442528 | We prospectively identified adult patients (aged ≥18 years) admitted to both hospitals from March 2 to April 1, 2020, who were diagnosed with laboratory-confirmed COVID-19 and were critically ill with acute hypoxaemic respiratory failure, and collected clinical, biomarker, and treatment data. […] Secondary outcomes included frequency and duration of invasive mechanical ventilation, frequency of vasopressor use and renal replacement therapy, and time to in-hospital clinical deterioration following admission. […] As of April 28, 2020, 101 (39%) patients had died and 94 (37%) remained hospitalised. 203 (79%) patients received invasive mechanical ventilation for a median of 18 days (IQR 9-28), 170 (66%) of 257 patients received vasopressors and 79 (31%) received renal replacement therapy. | 2020-05-26 |
| 32442699 | While evidence suggests that hydroxychloroquine (HCQ) may decrease the viral load in patients with a COVID-19 infection, a number of case reports indicate adverse dermatologic effects of this potential treatment. […] To conduct a systematic review of previously reported cases of psoriasis onset, exacerbation, or relapse after HCQ treatment. […] A comprehensive EMBASE and MEDLINE search of original studies examining adverse effects of HCQ treatment related to psoriasis was conducted. […] HCQ treatment may result in induction, exacerbation, or relapse of psoriasis. […] Monitoring for adverse effects of HCQ treatment is necessary, and clinical trials are essential in characterizing the safety profile of HCQ use in patients with a COVID-19 infection. | 2020-05-24 |
| 32442720 | At present, the efforts of various countries focus on the rapid diagnosis and isolation of patients, as well as to find a treatment that can combat the most serious impact of the disease. […] Unfortunately, no drugs or vaccines have been approved for the treatment of human coronaviruses, but there is an urgent need for in-depth research on emerging human infectious coronaviruses. […] Clarification transmission routes and pathogenic mechanisms, and identification of potential drug treatment targets will promote the development of effective prevention and treatment measures. | 2020-05-31 |
| 32442939 | In terms of myocardial infarction, a drop from 40% to 60% of the reperfusion treatment could increase mortality by 3% to 5%. | 2020-05-25 |
| 32442941 | Information about their safety and efficacy as antimalarials, antivirals, as well as in the long-term treatment of rheumatic diseases was collected. | 2020-05-25 |
| 32443020 | A third survey collected current practice of PIBD treatment. […] Eight PIBD children had COVID-19 globally, all with mild infection without needing hospitalization despite treatment with immunomodulators and/or biologics. […] No cases have been reported in China and South Korea but biologic treatment has been delayed in 79 children, of whom 17 (22%) had exacerbation of their IBD. […] Among the Porto group members, face-to-face appointments were often replaced by remote consultations but almost all did not change current IBD treatment. | 2020-05-27 |
| 32443163 | The pharmacological and immunological properties of interferons, especially those of interferon beta, and the corresponding treatment strategies are described, and the results of studies with different interferons in coronavirus infections are analysed. […] This regimen differs from those approved for treatment of multiple sclerosis and consists of interferon beta-1a administered as a 24 hour intravenous infusion at a daily dose of up to 90 µg for 3-5 consecutive days. […] Since under this regimen transient severe side effects can occur, it is analysed which patients are suitable for this kind of treatment in general and if patients with severe coronavirus infections could also be treated accordingly. | 2020-05-22 |
| 32443202 | The discharge of hospital wastes and wastewater, especially those without appropriate treatment would expose the public in danger of infection. | 2020-05-26 |
| 32443345 | Prone position ventilation, vasoconstrictor, antibacteria, and antiviral therapy were given. | 2020-05-25 |
| 32443442 | Here we evaluate clinical and imaging parameters for estimating the need of intensive care unit (ICU) treatment. […] Machine learning modelling was performed to estimate the risk for ICU treatment. […] The need for ICU treatment is independently associated with affected lung volume, radiological severity score, CRP, and IL-6. | 2020-05-25 |
| 32443911 | Unfortunately, there is still not a single proven effective drug available, and therefore, current therapeutic guidelines recommend supportive care including oxygen administration and treatment with antibiotics. | 2020-05-27 |
| 32444382 | Due to the urgent need of a therapeutic treatment for coronavirus (CoV) disease 2019 (COVID-19) patients, a number of FDA-approved/repurposed drugs have been suggested as antiviral candidates at clinics, without sufficient information. […] Despite the potential discrepancy of drug efficacies between animals and humans, these preclinical ferret data should be highly informative to future therapeutic treatment of COVID-19 patients.IMPORTANCE The SARS-CoV-2 pandemic continues to spread worldwide, with rapidly increasing numbers of mortalities, placing increasing strain on health care systems. […] Despite serious public health concerns, no effective vaccines or therapeutics have been approved by regulatory agencies. […] While most of the drug treatments marginally reduced clinical symptoms, they did not reduce virus titers, with the exception of emtricitabine-tenofovir treatment, which led to diminished virus titers in nasal washes at 8 dpi. | 2020-05-27 |
| 32444393 | Demographic, clinical, laboratory, and radiologic characteristics and treatment and outcomes data were analyzed. | 2020-05-23 |
| 32444415 | Deidentified data, including gender, age, laboratory and radiological results, symptoms, signs, and medication history, were collected from 2326 patients diagnosed with COVID-19, including 21 cases in combination with rheumatic disease, in Tongji Hospital between 13 January and 15 March 2020. | 2020-05-23 |
| 32444460 | Overall, 41% (8199/20 133) of patients were discharged alive, 26% (5165/20 133) died, and 34% (6769/20 133) continued to receive care at the reporting date. 17% (3001/18 183) required admission to high dependency or intensive care units; of these, 28% (826/3001) were discharged alive, 32% (958/3001) died, and 41% (1217/3001) continued to receive care at the reporting date. | 2020-05-28 |
| 32444482 | Studies of non- COVID-19 severe respiratory viral infections provide indirect, very low-quality evidence that raises the possibility that convalescent plasma has minimal or no benefit in the treatment of COVID-19 and low-quality evidence that it does not cause serious adverse events. | 2020-05-23 |
| 32444493 | To report clinical and laboratory characteristics, as well as treatment and clinical outcomes of patients admitted for neurologic diseases with and without COVID-19. […] Demographic, clinical, treatment, and laboratory data were extracted from medical records and compared (FDR-corrected) to those of neurologic patients without COVID-19 admitted in the same period. | 2020-05-23 |
| 32444504 | In this setting, with the serious threat imposed by the COVID-19 pandemic in the context of rapidly evolving knowledge with much unknown, it is important to weigh the risks and benefits of treatment strategies offered to older patients. | 2020-05-23 |
| 32444743 | In making the right choices, we have at hand a future integrated dental team care model with time to concentrate on personalised prevention advice, as well as the provision of effective, highly skilled treatment. | 2020-05-27 |
| 32444797 | Biobanks can be either integrated into healthcare, where preservation of the biological material is a fork in clinical routine diagnostics and medical treatment processes or they can also host prospective cohorts or material related to clinical trials. | 2020-05-29 |
| 32444866 | Patient education for personal hygiene and social distancing measures, along with treatment individualization, telemedicine and continuous surveillance for early diagnosis of COVID-19 are essential. […] In countries or local communities where COVID-19 infection is widely spread, MM patients should have a PCR test of nasopharyngeal swab for SARS-CoV-2 before hospital admission, starting a new treatment line, cell apheresis or ASCT in order to avoid ward or community spread and infections. […] Treatment initiation should not be postponed for patients with end organ damage, myeloma emergencies and aggressive relapses. […] Patients with MM and symptomatic COVID-19 disease should interrupt anti-myeloma treatment until recovery. […] For patients with positive PCR test for SARS-CoV-2, but with no symptoms for COVID-19, a 14-day quarantine should be considered if myeloma-related events allow the delay of treatment. | 2020-05-27 |
| 32445083 | Cancer wards have been subjected to several modifications to protect patients and healthcare professionals from COVID-19 infection, while attempting to maintain cancer diagnosis, therapy, and research. | 2020-05-26 |
| 32445105 | The innovative and pragmatic tiered study approach has allowed for rapid recruitment and activation of numerous sites across the world-an approach essential to capture real-time critical neurological data to inform treatment strategies in this pandemic crisis. | 2020-05-30 |
| 32445195 | Evidence- and experience-based treatment options such as multidisciplinary team care, feeding tubes, wheelchairs, home health and hospice have become more difficult to obtain and in some places are unavailable. | 2020-05-23 |
| 32445204 | The Child Neurology Society collaborated with the Pediatric Epilepsy Research Consortium to issue an online statement April 6, 2020 of immediate recommendations to streamline diagnosis, treatment, and follow up of infantile spasms. […] The recommendations encourage use of telemedicine, outpatient over inpatient studies, and oral therapies as initial treatment. | 2020-05-23 |
| 32445315 | The panel recommends deferring treatment of patients with renal cell carcinoma by 3 to 6 months, except for those with ongoing hematuria and/or inferior vena cava thrombus, which warrant immediate surgery. […] Metastatic renal cell cancers should be started on targeted therapy. […] Management of low and intermediate risk prostate cancer can be deferred for 3 to 6months while high risk prostate cancer patients can be initiated on neoadjuvant androgen deprivation therapy. […] Neoadjuvant chemotherapy should be avoided and adjuvant therapy should be deferred. […] We need to tailor our treatment strategies to the prevailing present conditions, so as to fight and defeat both, the SARS-CoV-2 virus and cancer. | 2020-05-29 |
| 32445330 | Appropriate triage and customization of treatment protocols can help curtail hospital visits and time-spent by cancer patients during pandemic times, thereby reducing their risk of exposure as well as allowing efficient utilization of resources. | 2020-05-29 |
| 32445440 | Although several therapeutic agents have been evaluated for the treatment of coronavirus disease 2019 (Covid-19), none have yet been shown to be efficacious. | 2020-05-23 |
| 32445484 | The opportunities for clinical pharmacology to contribute to the development of new treatments have already been described by others in Clinical Pharmacology & Therapeutics (2). | 2020-05-23 |
| 32445580 | Viral load of SARS-CoV-2 peaked within the first few days (2-4 days) after admission, then decreased rapidly along with virus rebound under treatment. […] The serial viral loads of patients revealed whole viral shedding during hospitalization and the resurgence of virus during the treatment, which could be used for early warning of illness severity, thus improve antiviral interventions. | 2020-05-23 |
| 32445881 | The duration of viral RNA of respiratory tract in the monotherapy group was not longer than that in the combined therapy group. […] We inferred that Arbidol/IFN - 2b therapy can be used as an effective method to improve the COVID-19 pneumonia of mild patients, although it helpless with accelerating the virus clearance. | 2020-05-26 |
| 32445904 | Preventative and non-pharmacologic interventions remain critical for managing delirium in such patients, though occasionally pharmacologic treatment is required. […] When use of an antipsychotic medication is indicated, we recommend that providers consider foregoing the lowest common dose and instead start with the next incrementally higher dose to more quickly and reliably ensure the safety of both patients and providers. […] We do not recommend initiating prophylactic treatment or escalating doses in a manner that conflicts with currently accepted guidelines without carefully considering the risks and benefits. | 2020-05-26 |
| 32445935 | Patients should be informed to safely proceed with their treatment and follow the rules for self-protection to COVID-19. | 2020-05-25 |
| 32445956 | This study may provide meaningful and useful information on further research to investigate the action mechanisms of Chinese medicines against SARS-CoV-2 and also provide a basis for sharing the “China scheme” for COVID-19 treatment. | 2020-05-31 |
| 32446037 | Early diagnosis is crucial for correct treatment in order to possibly reduce the stress in the healthcare system. | 2020-05-31 |
| 32446167 | We retrospectively summarized the characteristics, treatment and outcomes of pediatric cases in Wuhan Children’s Hospital which was the only designated hospital for children with COVID-19 in Hubei Province. […] The efficacy of the antiviral therapy in children with COVID-19 remains to be evaluated. | 2020-05-29 |
| 32446311 | Efficacy of conventional treatment plus the complementary therapy Liu-zi-jue (a mind-body exercise) to treat patients with mild COVID-19. | 2020-05-27 |
| 32446312 | Metformin was proposed to be a candidate for host-directed therapy for COVID-19. […] Antidiabetic treatment with metformin was associated with decreased mortality compared with diabetics not receiving metformin. | 2020-05-24 |
| 32446795 | The clinical features, treatment strategies and prognosis data were collected and analyzed. […] COVID-19 patients with diabetes were more likely to develop severe or critical disease conditions with more complications, and had higher incidence rates of antibiotic therapy, non-invasive and invasive mechanical ventilation, and death (11.1% vs. | 2020-05-26 |
| 32446801 | We will also highlight the recent treatment strategies being explored to control this pandemic. | 2020-05-27 |
| 32446813 | Traditional Chinese medicine (TCM) is capable of performing syndrome differentiation and treatment according to the clinical manifestations of patients, and has a better ability of epidemic prevention and control. […] The authors comprehensively analyzed the etiology and pathogenesis of COVID-19 based on the theory of TCM, and discussed its syndrome differentiation, treatment and prevention measures so as to provide strategies and reference for the prevention and treatment with TCM. | 2020-05-27 |
| 32446978 | This prospective cohort study of the correlates of the risk of death in COVID-19 patients was conducted at the Infectious Diseases and Intensive Care units of Luigi Sacco Hospital, Milan, Italy. | 2020-05-27 |
| 32447059 | This included scheduled outpatient cardiac surgical and interventional procedures that required the use of intensive care units, ventilators, and skilled critical care personnel, given that these procedures would draw from the same pool of resources required for critically ill COVID-19 patients. | 2020-05-27 |
| 32447101 | The prevalence of diabetes patients hospitalized in intensive care units for COVID-19 is two- to threefold higher, and the mortality rate at least double, than that of non-diabetes patients. | 2020-05-26 |
| 32447102 | Yet, in spite of this therapy, patients with vs. patients without diabetes have an adverse disease course. | 2020-05-30 |
| 32447292 | The recent joint statement from the American Society of Regional Anesthesia and Pain Medicine (ASRA) and the European Society of Regional Anesthesia and Pain Therapy (ESRA) recommends neuraxial and peripheral nerve blocks for patients with coronavirus disease 2019 (COVID-2019) illness. | 2020-05-24 |
| 32447429 | The purpose of this review is to quantify the landscape of current clinical trials ongoing for therapies in the treatment of COVID-19. […] There were 341 interventional studies and 208 different therapies actively registered on clinicaltrials.gov whose primary aim is the treatment of COVID-19. | 2020-05-27 |
| 32447603 | •The most frequently discussed topics in videos were the place of hydroxychloroquine in the treatment of COVID-19 and whether to continue the use of existing rheumatological drugs. | 2020-05-27 |
| 32447777 | However, the intent to prevent the spread of this lethal respiratory disease will likely lead to reduced treatment access due to restrictions on population movements. […] The methods presented include committee-based prioritization of dental patients, a multilayered screening process, team rotations with social and temporal spacing, and modified treatment room protocols. | 2020-05-29 |
| 32447820 | With no definite treatment, as of now, encouraging reports of some anti-viral and anti-malarial drugs in the management of COVID-19 generate some hope. | 2020-05-24 |
| 32447846 | In order to better fight against the epidemic and give full play to the advantages of traditional Chinese medicine, we explored the feasibility of acupuncture therapy in the intervention of COVID-19 through analyzing the relevant literature in both ancient and modern time. […] It was proposed that the advantages of acupuncture and moxibustion should be fully displayed while Chinese herbal medications have been applied in the treatment of COVID-19. […] During treatment, acupuncture physicians should be rationally allocated to a certain proportion so as to adequately utilize comprehensive therapeutic approaches and guarantee people’s safety to the greatest extent. | 2020-05-27 |
| 32447934 | The timing and protocol of anticoagulation therapy are still under investigation based on more clinical data. 目的： 总结合并肢端缺血的新型冠状病毒肺炎（COVID-19）患者的临床和凝血功能特征。 | 2020-05-26 |
| 32448039 | Currently there are no approved drugs for the treatment of coronaviral disease (COVID-19), although some of the drugs have been tried. […] Chloroquine is being widely used in treatment of SARS-CoV-2 infection. | 2020-05-25 |
| 32448333 | Questions about institutional rules and personal approach for patient treatment and to limit epidemic spread were included in a 37-item questionnaire. […] Up to 40% of non-traumatic abdominal emergency cases had an unusual delayed treatment. | 2020-05-28 |
| 32448345 | The primary endpoint is time to clinical improvement (censored at day 28), defined as the time (in days) from randomization of study treatment (remdesivir or placebo) until a decline of two categories on a six-category ordinal scale of clinical status (1 = discharged; 6 = death) or live discharge from hospital. | 2020-05-27 |
| 32448377 | Although scientific advancements have allowed for rapid progress to be made to understand the pathogenesis and develop therapeutics after each viral pandemic, few effective methods to treat virus-induced ALI have been described. […] Recently, stem cell therapy has been widely used in the treatment of various diseases, including ALI. […] In this review, we detail the present stem cell-based therapeutics for lung injury caused by influenza virus and the outlook for the future state of stem cell therapy to deal with emerging influenza and coronaviruses. | 2020-05-28 |
| 32448490 | There has been no specific treatment against 2019-nCoV up to now, and physicians only apply supportive therapy. […] We hope that this review has a positive impact on public knowledge for helping to deal with the 2019-nCoV and move one step forward toward its treatment in the near future. | 2020-05-27 |
| 32448818 | To examine the effects of protease inhibitors on the replication of coronavirus 229E, we pretreated primary cultures of human nasal epithelial (HNE) cells with camostat or nafamostat, each of which has been used for the treatment of pancreatitis and/or disseminated intravascular coagulation. […] Pretreatment with camostat (0.1-10 μg/mL) or nafamostat (0.01-1 μg/mL) reduced the titers of coronavirus 229E. | 2020-05-29 |
| 32449022 | Considering its potential benefits and high availability, acetic acid disinfection appears to be a promising adjunctive therapy in cases of non-severe COVID-19 and deserves further investigation. | 2020-05-28 |
| 32449057 | His condition worsened and he died after more than 2 weeks of hospitalization and aggressive treatment. | 2020-05-28 |
| 32449128 | We described Covid-19 cumulative incidence, treatment outcome, mortality, and associated risk factors. […] Patients who combined hydroxychloroquine and azithromycin presented 3/18 deaths, regardless of age, staging, histology, cancer treatment and comorbidities (OR 0.02, p = 0.03). […] Combined hydroxychloroquine and azithromycin is presented as a good treatment option. | 2020-05-28 |
| 32449169 | Since the beginning of the COVID-19 pandemic, the use of convalescent plasma as a possible treatment has been explored. […] Within weeks, we were able to distribute over 8000 products, scale up collections to over 4,000 units per week, meet hospital demand, as well as support randomized controlled trials to evaluate the efficacy of convalescent plasma treatment. | 2020-05-25 |
| 32449224 | The clinical characteristics, laboratory tests, treatment features and prognoses were summarized. […] Throughout a patient’s hospitalization, their treatment plan should be evaluated and adjusted according to their vital signs, clinical symptoms, laboratory tests and imaging changes. | 2020-05-25 |
| 32449235 | Although immunosuppressed patients may be more prone to SARS-CoV-2 infection with atypical presentation, long-term immunosuppression therapy may provide some sort of protection for severe clinical complications of COVID-19. […] The interaction between immunosuppression and new antiviral drugs in the treatment of transplanted patients contracting COVID-19 has not yet been fully investigated. | 2020-05-25 |
| 32449333 | Confronted with thousands of deaths daily worldwide, we have to build quickly the rationale behind the treatment, taking advantage from past analogues. | 2020-05-25 |
| 32449523 | In response to this shift, Waller and colleagues compiled a series of expert recommendations to help clinicians pivot to delivering teletherapy to address eating disorders during COVID-19. | 2020-05-25 |
| 32449528 | Motor and nonmotor symptoms significantly worsened in the COVID-19 group, requiring therapy adjustment in one-third of cases. […] Clinical deterioration was explained by both infection-related mechanisms and impaired pharmacokinetics of dopaminergic therapy. | 2020-05-25 |
| 32449757 | Caring for older patients with breast cancer presents unique clinical considerations due to preexisting and competing comorbidity, the potential for treatment-related toxicity, and the consequent impact on functional status. […] In the context of the COVID-19 pandemic, treatment decision-making for older patients is especially challenging and encourages us to re-focus our treatment priorities. […] While we work to avoid treatment delays and maintain therapeutic benefit, we also need to minimize the risk for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) exposures, myelosuppression, general chemotherapy toxicity, and functional decline. […] Herein, we propose multidisciplinary care considerations for the aging patient with breast cancer, with the goal to promote a team-based, multidisciplinary treatment approach during the COVID-19 pandemic and beyond. | 2020-05-25 |
| 32449792 | In this brief report we describe, our first single-centre experience from a 58-year-old Caucasian male patient with HIV who developed a severe SARS-CoV-2 infection, including clinical characteristics, treatment, and outcomes. | 2020-05-25 |
| 32449972 | We also described electrocardiogram findings, complications, and treatment during hospitalization in detail. | 2020-05-25 |
| 32449999 | To evaluate the impact of the coronavirus pandemic and the quarantine in orthodontic appointments, and patients’ anxiety and concerns about their ongoing orthodontic treatment. […] Settings and sample population Patients from private dental clinics of two orthodontists that were undergoing active orthodontic treatment. […] The greatest concern of patients was delay in the end of treatment. […] Delay in treatment was the greatest concern of patients undergoing orthodontic treatment. | 2020-05-25 |
| 32450087 | To-date, there has not been a clear signal suggesting that asthma or treatment with inhaled steroids are a risk factor for severe COVID-19 disease. […] These data suggest that differences in ACE2, TMPRSS2 and furin epithelial and airway gene expression are unlikely to confer enhanced COVID-19 pneumonia risk in patients with asthma across all treatment intensities and severity. | 2020-05-28 |
| 32450107 | Hydroxychloroquine or chloroquine, often in combination with a second-generation macrolide, are being widely used for treatment of COVID-19, despite no conclusive evidence of their benefit. […] Although generally safe when used for approved indications such as autoimmune disease or malaria, the safety and benefit of these treatment regimens are poorly evaluated in COVID-19. […] We did a multinational registry analysis of the use of hydroxychloroquine or chloroquine with or without a macrolide for treatment of COVID-19. […] Patients who received one of the treatments of interest within 48 h of diagnosis were included in one of four treatment groups (chloroquine alone, chloroquine with a macrolide, hydroxychloroquine alone, or hydroxychloroquine with a macrolide), and patients who received none of these treatments formed the control group. […] Of these, 14 888 patients were in the treatment groups (1868 received chloroquine, 3783 received chloroquine with a macrolide, 3016 received hydroxychloroquine, and 6221 received hydroxychloroquine with a macrolide) and 81 144 patients were in the control group. 10 698 (11·1%) patients died in hospital. […] Each of these drug regimens was associated with decreased in-hospital survival and an increased frequency of ventricular arrhythmias when used for treatment of COVID-19. | 2020-05-29 |
| 32450198 | The chloroquine (CQ) and its analogue hydroxychloroquine (HCQ) have been used as frontline drugs for treatment and prophylaxis against all types of human malaria worldwide. […] Considering the global health crisis of the COVID-19 pandemic, the option of using the drugs and repurposing of old drugs in this instance, chloroquine and hydroxychloroquine, specifically, hydroxychloroquine in the treatment of SARS-CoV-2 could be the best choice. […] Given that there is no cure for COVID-19, the clinical testing of HCQ is urgently needed to ascertain its potency against the virus as this is the current available treatment option. | 2020-05-28 |
| 32450344 | Our objective was to explore the effects of the administration of anti-platelet therapy on arterial oxygenation and clinical outcomes in patients with severe Covid-19 with hypercoagulability. […] Treated patients consistently experienced a mean (SD) reduction in A-a O2 gradient of -32.6 mmHg (61.9, P = 0.154), -52.4 mmHg (59.4, P = 0.016) and -151.1 mmHg (56.6, P = 0.011; P = 0.047 vs. controls) at 24, 48 hours and 7 days after treatment. […] Antiplatelet therapy might be effective in improving the ventilation/perfusion ratio in Covid-19 patients with severe respiratory failure. | 2020-05-28 |
| 32450346 | Understanding the dynamic progression of SARS-CoV-2 infection is crucial to determine an effective treatment strategy to reduce the rising mortality of this global pandemic. | 2020-05-28 |
| 32450629 | Convalescent plasma (CP) therapy refers to a therapy infusing plasma from recovered donors into other infected individuals. […] This article provides a reference for clinical application of CP therapy in COVID-19, by discussing the history, mechanism and application of CP therapy in viral diseases such as SARS. | 2020-05-26 |
| 32450629 | Convalescent plasma (CP) therapy refers to a therapy infusing plasma from recovered donors into other infected individuals. […] This article provides a reference for clinical application of CP therapy in COVID-19, by discussing the history, mechanism and application of CP therapy in viral diseases such as SARS. | 2020-05-26 |
| 32450629 | Convalescent plasma (CP) therapy refers to a therapy infusing plasma from recovered donors into other infected individuals. […] This article provides a reference for clinical application of CP therapy in COVID-19, by discussing the history, mechanism and application of CP therapy in viral diseases such as SARS. | 2020-05-26 |
| 32450629 | Convalescent plasma (CP) therapy refers to a therapy infusing plasma from recovered donors into other infected individuals. […] This article provides a reference for clinical application of CP therapy in COVID-19, by discussing the history, mechanism and application of CP therapy in viral diseases such as SARS. | 2020-05-26 |
| 32450629 | Convalescent plasma (CP) therapy refers to a therapy infusing plasma from recovered donors into other infected individuals. […] This article provides a reference for clinical application of CP therapy in COVID-19, by discussing the history, mechanism and application of CP therapy in viral diseases such as SARS. | 2020-05-26 |
| 32450629 | Convalescent plasma (CP) therapy refers to a therapy infusing plasma from recovered donors into other infected individuals. […] This article provides a reference for clinical application of CP therapy in COVID-19, by discussing the history, mechanism and application of CP therapy in viral diseases such as SARS. | 2020-05-26 |
| 32450629 | Convalescent plasma (CP) therapy refers to a therapy infusing plasma from recovered donors into other infected individuals. […] This article provides a reference for clinical application of CP therapy in COVID-19, by discussing the history, mechanism and application of CP therapy in viral diseases such as SARS. | 2020-05-26 |
| 32450629 | Convalescent plasma (CP) therapy refers to a therapy infusing plasma from recovered donors into other infected individuals. […] This article provides a reference for clinical application of CP therapy in COVID-19, by discussing the history, mechanism and application of CP therapy in viral diseases such as SARS. | 2020-05-26 |
| 32450629 | Convalescent plasma (CP) therapy refers to a therapy infusing plasma from recovered donors into other infected individuals. […] This article provides a reference for clinical application of CP therapy in COVID-19, by discussing the history, mechanism and application of CP therapy in viral diseases such as SARS. | 2020-05-26 |
| 32450629 | Convalescent plasma (CP) therapy refers to a therapy infusing plasma from recovered donors into other infected individuals. […] This article provides a reference for clinical application of CP therapy in COVID-19, by discussing the history, mechanism and application of CP therapy in viral diseases such as SARS. | 2020-05-26 |
| 32450629 | Convalescent plasma (CP) therapy refers to a therapy infusing plasma from recovered donors into other infected individuals. […] This article provides a reference for clinical application of CP therapy in COVID-19, by discussing the history, mechanism and application of CP therapy in viral diseases such as SARS. | 2020-05-26 |
| 32450629 | Convalescent plasma (CP) therapy refers to a therapy infusing plasma from recovered donors into other infected individuals. […] This article provides a reference for clinical application of CP therapy in COVID-19, by discussing the history, mechanism and application of CP therapy in viral diseases such as SARS. | 2020-05-26 |
| 32450629 | Convalescent plasma (CP) therapy refers to a therapy infusing plasma from recovered donors into other infected individuals. […] This article provides a reference for clinical application of CP therapy in COVID-19, by discussing the history, mechanism and application of CP therapy in viral diseases such as SARS. | 2020-05-26 |
| 32450629 | Convalescent plasma (CP) therapy refers to a therapy infusing plasma from recovered donors into other infected individuals. […] This article provides a reference for clinical application of CP therapy in COVID-19, by discussing the history, mechanism and application of CP therapy in viral diseases such as SARS. | 2020-05-26 |
| 32450629 | Convalescent plasma (CP) therapy refers to a therapy infusing plasma from recovered donors into other infected individuals. […] This article provides a reference for clinical application of CP therapy in COVID-19, by discussing the history, mechanism and application of CP therapy in viral diseases such as SARS. | 2020-05-26 |
| 32450629 | Convalescent plasma (CP) therapy refers to a therapy infusing plasma from recovered donors into other infected individuals. […] This article provides a reference for clinical application of CP therapy in COVID-19, by discussing the history, mechanism and application of CP therapy in viral diseases such as SARS. | 2020-05-26 |
| 32450630 | With the update of the “Diagnosis and Treatment Protocol for Novel Coronavirus Pneumonia” from the National Health Commission of China, the military medical expert group on the front-line has formulated the “Diagnosis and Treatment Protocol for COVID-19 from Military Medical Team Supporting Wuhan(Trial Version 2)” . | 2020-05-26 |
| 32450631 | The general information, clinical symptoms, blood test, virus nucleic acid test results, epidemiology, CT imaging, treatment and prognosis were analyzed. […] Early detection, early isolation, early diagnosis and early treatment are important for good prognosis. | 2020-05-26 |
| 32450718 | In this dramatic scenario, all the resources are addressed to the intensive care units for the assessment of the emergency. | 2020-05-26 |
| 32450756 | The COVID-19 pandemic has placed a significant personnel burden on intensive care units across the globe. | 2020-05-26 |
| 32450761 | During the SARS-CoV-2 pandemic, patients in intensive care units who are undergoing long-term intubation may require tracheostomy. | 2020-05-26 |
| 32450787 | In the context of COVID-19, clinicians will have to determine whether liver injury is related to an underlying liver disease, drugs used for the treatment of COVID-19, direct effect of the virus, or a complicated disease course. | 2020-05-28 |
| 32450906 | The sex and gender disparities observed in COVID-19 vulnerability emphasize the need to better understand the impact of sex and gender on incidence and case fatality of the disease and to tailor treatment according to sex and gender. […] The ongoing and planned prophylactic and therapeutic treatment studies must include prospective sex- and gender-sensitive analyses. | 2020-05-29 |
| 32451259 | Many emerging evidences have converged on the effectiveness of HQ in the treatment of Covid-19 infection. | 2020-05-28 |
| 32451271 | Before an effective vaccine or medicine is available, supportive therapy and identifying patients who are at high risk of cardiac complications are important. | 2020-05-28 |
| 32451343 | The current advice available to doctors appears to be inconsistent, with some suggesting withdrawal of treatment is more serious than withholding, while others suggest that this distinction should not be made. […] We argue that there is no ethically relevant difference between withdrawing and withholding treatment and that suggesting otherwise may have problematic consequences. […] If doctors are discouraged from withdrawing treatment, concern about a future shortage may make them reluctant to provide ventilation to patients who are unlikely to have a successful outcome. | 2020-05-26 |
| 32451351 | However, we highlight several considerations regarding treatment with high dose HCQ. | 2020-05-26 |
| 32451354 | Carlos Antonio Moura and Ana Luísa Cerqueira de Sant’Ana Costa emphasizes the need to understand mechanisms of disease underlying the more serious complications of Covid-19 infection as well as provide the best treatment possible to large numbers of seriously ill patients during a global pandemic (2). | 2020-05-26 |
| 32451655 | In addition, 12 patients needing hospitalization for planning a non-deferrable elective surgical treatment were included. | 2020-05-29 |
| 32451736 | Quaternary ammonium compounds such as ammonium chloride, cetylpyridinium and miramistin represent widely accessible antiseptic molecules with well-known broad-spectrum antiviral activities and represent a repurposing opportunity as therapeutics against SARS-CoV-2. | 2020-05-29 |
| 32452539 | Since the causative agent, SARS-CoV-2, is a recently discovered species, there is no specific medicine for downright treatment of the infection. […] Herein, the COVID-19 structure, epidemiology, pathogenesis, etiology, diagnosis, and therapy have been reviewed. | 2020-05-26 |
| 32452700 | The Canadian Society of Breast Imaging/Canadian Association of Radiologists guideline for breast imaging during COVID-19 is provided based on priority according to risk of breast cancer and impact of delaying treatment. | 2020-05-26 |
| 32452746 | In all 3 cases, the procedure was delayed, and patients were admitted for treatment or discharged under home quarantine. […] During this period, 86% of operative procedures were indicated for treatment of oncologic disease. | 2020-05-26 |
| 32452838 | It is challenging for this population to access public information regarding COVID-19 testing, treatment, and assistance programs because this information is seldom disseminated in Spanish and even less frequently in Portuguese. | 2020-05-26 |
| 32452888 | Mortality was significantly associated with older age, lower body mass index, chronic renal disease, higher Sequential Organ Failure Assessment score, lower PaO2/FIO2 ratio, higher D-dimer, higher C-reactive protein, and receipt of mechanical ventilation, vasopressors, renal replacement therapy, or vasodilator therapy. | 2020-05-31 |
| 32452905 | The impact of this cessation of pain treatment may have unintended consequences of increased pain, reduced function, increased reliance on opioid medications and potential increased morbidity, due to the systemic impact of untreated disease burden. | 2020-05-30 |
| 32452947 | VV ECMO can be utilized as an advanced therapy in select patients with COVID-19 respiratory failure refractory to traditional critical care management and optimal mechanical ventilation. […] Anticipating a need for such therapies during the pandemic, our center created a targeted protocol for ECMO therapy in COVID-19 patients that allows us to provide this life-saving therapy to our sickest patients without overburdening already stretched resources or excessively exposing healthcare staff to infection risk. […] The median duration of VV ECMO therapy for patients who have been decannulated is 12 days (4-18 days). | 2020-05-26 |
| 32452954 | COVID-19 emergency shocked national health systems, subtracting resources from treatment of other diseases. […] The commonest criteria to prioritize surgery were tumor biology (80%), time interval from neoadjuvant therapy (61%), risk of becoming unresectable (57%), and tumor-related symptoms (52%). | 2020-05-26 |
| 32452979 | Despite inpatient treatment for COVID-19 and a perianal abscess, the patient acutely decompensated, with worsening fever, tachycardia, fluid-refractory hypotension, elevation of liver enzymes, and transformation of the rash into purpura extending from the face to the trunk, upper and lower extremities, including the palmar and plantar surfaces of the hands and feet. […] Within hours of infliximab treatment, fever, tachycardia and hypotension resolved. […] This case supports a role for blockade of TNF-α in the treatment of COVID-19 inflammatory cascade. | 2020-05-26 |
| 32453656 | We recommend that general principles of lung cancer treatment continue to be followed in most cases where delays could result in rapid cancer progression. […] In principle, however, treatment paradigms must continue to be individualized, with careful consideration of risks and benefits of continuing or altering lung cancer-directed therapy. | 2020-05-26 |
| 32453685 | We describe 2 cases in coronavirus disease patients in France involving presumed thrombotic stroke that occurred during ongoing anticoagulation treatment for atrial fibrillation stroke prophylaxis; 1 patient had positive antiphospholipid antibodies. | 2020-05-26 |
| 32453687 | Passive immunotherapy with plasma derived from convalescent patients recovering from SARS-CoV-2 infection can be a promising approach in the treatment of COVID-19 patients. | 2020-05-29 |
| 32453702 | These findings encourage further investigations to elucidate the underlying pathophysiology of thromboembolic events in COVID-19 patients and may support the introduction of full dose anticoagulation with or without antiplatelet therapy. […] Interventional clinical trials may be helpful in defining the appropriate drug(s), for this purpose, the algorithms of administration, and the optimal duration of therapy. | 2020-05-28 |
| 32454090 | Longitudinal outcome data can then be combined with other epidemics and old-age health data, to discover the best biomarkers to predict (i) coping with infection & inflammation and thus hospitalization or intensive care, (ii) long-term health challenges, e.g. deterioration of lung function after intensive care, and (iii) treatment & vaccination response. | 2020-05-29 |
| 32454157 | The outbreak of COVID-19 caused by 2019-nCov/SARS-CoV-2 has become a pandemic with an urgent need for understanding the mechanisms and identifying a treatment. […] Considering the properties of both compounds in terms of anti-inflammatory, antioxidant, anti-pyrogenic, anti-viral and ER stress modulation and computational approaches revealing andrographolide docks with the SARS-CoV2 binding site, we predict that this combination therapy may have potential utility against COVID-19. | 2020-05-31 |
| 32454184 | The rapid spread of SARS-CoV-2 creates surges of infected patients requiring hospitalization and puts palliative care programs at risk of being overwhelmed by patients, families, and clinicians seeking help. […] In response to this unprecedented need for palliative care, our program sought to create a collection of palliative care resources for non-palliative care clinicians. […] A workgroup of interdisciplinary palliative care clinicians developed the Palliative Care Toolkit, consisting of a detailed chapter in a COVID-19 online resource, a mobile and desktop web application, one-page guides, pocket cards, and communication skills training videos. […] We also created a nurse resource hotline staffed by palliative care nurse practitioners and virtual office hours staffed by a palliative care attending physician. […] Since its development, the Toolkit has helped us disseminate best practices to non-palliative care clinicians delivering primary palliative care, allowing our team to focus on the highest-need consults, and increasing acceptance of palliative care across hospital settings. | 2020-05-29 |
| 32454186 | As healthcare institutions mobilize resources to address the coronavirus disease 2019 (COVID-19) pandemic, palliative care may potentially be underutilized. […] It is important to assess the use of palliative care in response to the COVID-19 pandemic. […] An analysis of the utilization of palliative care in accordance with patient comorbidities and other characteristics was performed while considering clinical outcomes. […] The overall mortality rate was 21.5% (n=52) and in 48% (n=25) of these patients, palliative care was not involved. […] Among those classified as having severe COVID-19, only 40% (n=31) had palliative care involvement. […] Patients who got palliative care consults were of older age, had higher rates of intubation, need for vasopressors, and death. […] There was a low utilization rate of palliative care in patients with COVID-19. […] Conscious utilization of palliative care is needed at the time of COVID-19. | 2020-05-29 |
| 32454187 | Currently, numerous trials testing potential treatment and preventative options are undertaken all over the world. […] We summarised all registered clinical trials examining treatment and prevention options for COVID-19. […] Registered clinical trials examining treatment and/or prevention options for COVID-19 were included. […] Interventional treatment studies were mostly randomised (n=150, 76%) and open-label (n=73, 37%) with a median number of planned inclusions of 90 (IQR 40-200). | 2020-05-29 |
| 32454253 | Prioritization among oncologic cases represents a difficult task: clinicians have to balance a possible delay in cancer diagnosis or treatment against the risk for a potential COVID-19 exposure. | 2020-05-29 |
| 32454500 | Ongoing advances in technology and science and progress in information technology support the development of integrated multi-organ support platforms for personalized treatment according to the changing needs of the patient. […] In the absence of vaccines or direct therapy for COVID-19, extracorporeal therapies could represent an option to prevent organ failure and improve survival. | 2020-05-26 |
| 32454512 | In addition, CB6 inhibited SARS-CoV-2 infection in rhesus monkeys at both prophylactic and treatment settings. | 2020-05-26 |
| 32454888 | At present, COVID-19 has no specific therapeutic drugs, and the main clinical treatment is symptomatic treatment and control of complications. […] On March 5, 2020, the National Health Commission of the People’s Republic of China issued the Guidelines for the Diagnosis and Treatment of Novel Coronavirus (2019-nCoV) Infection (Trial Version 7), which integrated traditional Chinese medicine (TCM) into the treatment of COVID-19. […] The purpose of this study is to summarize recent studies on the clinic application, pharmacological action, chemical substances and mechanism of Qingwen Baidu Decoction (QBD) on the treatment of various diseases. […] It has been used in the treatment of sepsis, epidemic hemorrhagic fever, epidemic cerebrospinal meningitis, infantile pneumonia, sepsis-related encephalopathy, epidemic encephalitis B and other diseases. […] In addition, this study attempts to explore the possible mechanism of QBD in the prevention and treatment of COVID-19. […] Through the analysis of the chemical substances, pharmacological action and mechanism of QBD, this paper will provide a reference theoretical basis for the prevention and treatment of COVID-19 by QBD. | 2020-05-29 |
| 32454982 | Amid COVID-19 Crisis, reporting adverse drug reactions (ADRs) and medical device incidents (MDIs) to Health Canada or health authorities in every country is crucial for monitoring medication safety and improving public health. | 2020-05-28 |
| 32454983 | Coronavirus sparks fear of medication shortage. | 2020-05-28 |
| 32454984 | Most of the drugs that are being tried for the treatment have not been evaluated in any randomized controlled trials. | 2020-05-29 |
| 32455090 | We suggest that whenever a suspected COVID-19 patient is transferred to a specialized center, they should be isolated and re-checked before joining the new patient population for treatment of the unique condition. | 2020-05-29 |
| 32455168 | We review three issues of importance for microallocation: (1) Prediction of benefit (or of medical futility) may be technically very challenging; (2) When resources are scarce, calibration is less important for microallocation than is ranking to prioritize patients, since capacity determines thresholds for resource utilization; (3) The concept of group fairness, which is not germane in shared decision-making, is of central importance in microallocation. | 2020-05-29 |
| 32455475 | Little is known how cancer treatment engaging immune checkpoints affects the course of COVID-19. | 2020-05-26 |
| 32455515 | Objective: To analyse the clinical history, laboratory tests and pathological data of a patient who suffered from novel coronavirus pneumonia(COVID-19) and provide reference for the clinical treatment of similar cases. Methods: Data of clinical manifestation, laboratory examination, bronchoscopy, echocardiography and cardiopulmonary pathological results were retrospectively reviewed in a case of COVID-19 with rapid exacerbation from mild to critical condition. Results: This patient hospitalized at day 9 post 2019 novel coronavirus(2019-nCoV) infection, experienced progressive deterioration from mild to severe at day 11, severe to critical at day 18 and underwent extracorporeal membrane oxygenation(ECMO) and continuous renal replacement therapy(CRRT) as well as heart lung transplantation during day 28-45 day post infection, and died on the second day post heart and lung transplantation. | 2020-05-26 |
| 32455534 | Thus, there remains an urgent need for the identification and development of specific antiviral therapeutics against SARS-CoV-2. | 2020-05-27 |
| 32455629 | Quercetin has been identified as one of top-scoring candidate therapeutics in the supercomputer SUMMIT drug-docking screen and Gene Set Enrichment Analyses (GSEA) of expression profiling experiments (EPEs), indicating that highly structurally similar quercetin, luteolin, and eriodictyol could serve as scaffolds for the development of efficient inhibitors of SARS-CoV-2 infection. […] In line with the results of present analyses, a randomized interventional clinical trial evaluating effects of estradiol on severity of the coronavirus infection in COVID19+ and presumptive COVID19+ patients and two interventional randomized clinical trials evaluating effects of vitamin D on prevention and treatment of COVID-19 were listed on the ClinicalTrials.gov website. | 2020-05-27 |
| 32455894 | In this manuscript, we address the unique issues regarding treatment prioritization for the patient with bladder cancer and how we at City of Hope have adjusted our clinical practices using a team-based approach that utilizes shared decision making with all stakeholders (physicians, patients, caregivers) to optimize outcomes during this difficult time. […] In addition to taking standard precautions for minimizing COVID-19 risk of exposure for those entering a healthcare facility (screening all personnel upon entry and donning facemasks at all times), we suggest the following three measures: (1) delay post-treatment surveillance visits until there is a decrease in local COVID-19 cases, (2) continue curative intent treatments for localized bladder cancer with COVID-19 precautions (i.e., choosing gemcitabine/cisplatin (GC) over dose-dense methotrexate, vinblastine, doxorubicin, cisplatin (ddMVAC) neoadjuvant chemotherapy), and (3) increase the off-treatment period between cycles of palliative systemic therapy in metastatic urothelial carcinoma patients. | 2020-05-27 |
| 32455961 | Severely affected patients are referred to intensive care units (ICUs), limiting their possibilities for physical exercise. […] Whole body vibration (WBV) exercise is a non-invasive, physical therapy, that has been suggested as part of the procedures involved with pulmonary rehabilitation, even in ICU settings. | 2020-05-29 |
| 32456064 | Patients with diabetes have been reported to have enhanced susceptibility to severe or fatal COVID-19 infections, including a high risk of being admitted to intensive care units with respiratory failure and septic complications. | 2020-05-29 |
| 32456123 | This review aims to evaluate the effectiveness and adverse events of herbal medicines for the treatment of COVID-19. […] Randomized controlled trials (RCTs) and quasi-RCTs assessing the effects of herbal medicines for the treatment of COVID-19 were eligible. […] All included trials compared the combined therapy of herbal medicine with Western medicine to Western medicine alone. […] The combined therapy significantly improved the total effective rate (RR 1.23, 95% CI 1.13 to 1.34, p < 0.001), cough symptom disappearance rate (RR 1.45, 95% CI 1.12 to 1.89, p = 0.005), and sputum production symptom disappearance rate (RR 1.73, 95% CI 1.19 to 2.50, p = 0.004). […] Beneficial effects of the combined therapy were also seen in TCM syndrome score of cough (MD -1.18, 95% CI -1.34 to -1.03, p < 0.001), fever (MD -0.62, 95% CI -0.79 to -0.45, p < 0.001), dry and sore throat (MD -0.83, 95% CI -1.45 to -0.20, p = 0.009), and fatigue (MD -0.60, 95% CI -1.04 to -0.17, p = 0.007). […] Significant effects of the combined therapy of herbal medicine with Western medicine were found, and revealed the potential role of herbal medicine in treating COVID-19. […] More high-quality RCTs are needed to further validate the effectiveness and adverse events of herbal medicine in the treatment of COVID-19. | 2020-05-27 |
| 32456286 | Our study suggested that HCQ and rfIFN-ω are applicable for treatment of FIP. […] Further clinical studies are needed to verify the combination of HCQ and rIFN-ω will be effective and safe treatment for cats with FIP. | 2020-05-29 |
| 32456368 | Therefore, understanding the differences and similarities of ARDS induced by COVID-19 and other diseases currently are the basis for clinicians to make decisions for the treatment of COVID-19 induced ARDS. | 2020-05-29 |
| 32456948 | Medical records including demographic data, medical history, clinical characteristics, laboratory examinations, chest computed tomography (CT), and treatment measures were collected, analyzed, and compared between the two groups. | 2020-05-29 |
| 32457036 | Since the availability of resources for diagnostic procedures, surgery and postoperative care, systemic therapy and radiotherapy may differ, authors did separate prioritisation analyses. | 2020-05-29 |
| 32457038 | However, newly evolving viral mutations, the prospect of only temporary immunity, and a long path to regulatory approval pose significant challenges and call for a common, readily available and inexpensive treatment. | 2020-05-27 |
| 32457086 | For patient safety, it will be critical to follow the WHO guidance regarding: a standard operating procedure; clinical protocols for when video consultations can (and cannot) be used; policies to ensure equity of access in disadvantaged populations; adequate staff training; and administrative support to coordinate appointments. | 2020-05-27 |
| 32457133 | The existing strain on dialysis capacity will be exacerbated as patients remain on dialysis as the only available form of renal replacement therapy. | 2020-05-27 |
| 32457227 | Evaluation of cause, clinical symptoms, and treatment response. […] The patient showed no response to steroid therapy and died on the eighth day of admission. | 2020-05-29 |
| 32457932 | CQ may also cause seizures, often refractory to standard treatment. […] The treatment of CQ/HCQ poisoning includes high-dose intravenous diazepam postulated to have positive ionotropic and antidysrhythmic properties that may antagonize the cardiotoxic effects of CQ. […] Current scientific evidence does not support treatment or prophylactic use of these agents for COVID-19 disease. | 2020-05-30 |
| 32458019 | Further research is needed to corroborate this assumption and identify those patients who may benefit from this treatment pathway. | 2020-05-29 |
| 32458021 | Acute kidney injury (AKI) requiring renal replacement therapy (RRT) is common in critically ill patients with COVID-19. | 2020-05-29 |
| 32458121 | In a recent issue published in the European Archives of Otorhinolaryngology, Mattioli et al. published a short communication about tracheostomy timing in patients with COVID-19 (Coronavirus Disease 2019); they reported that the tracheostomy could allow early Intensive Care Units discharge and, in the context of prolonged Invasive Mechanical Ventilation, should be suggested within 7 and 14 days to avoid potential tracheal damages. | 2020-05-29 |
| 32458149 | The current COVID-19 pandemic caused by SARS-CoV-2 has prompted investigators worldwide to search for an effective anti-viral treatment. […] A number of anti-viral drugs such as ribavirin, remdesivir, lopinavir/ritonavir, antibiotics such as azithromycin and doxycycline, and anti-parasite such as ivermectin have been recommended for COVID-19 treatment. […] In addition, sufficient pre-clinical rationale and evidence have been presented to use chloroquine for the treatment of COVID-19. […] Besides, Zn supplement can favour COVID-19 treatment using those suggested and/or recommended drugs. […] Given those benefits, this perspective paper describes how and why Zn could be given due consideration as a complement to the prescribed treatment of COVID-19. | 2020-05-29 |
| 32458206 | Recent publications on SARS-CoV-2 have brought attention to the possible benefit of chloroquine in the treatment of patients infected by SARS-CoV-2. […] An effective prophylactic medication to prevent viral entry has to contain, at least, either a protease inhibitor or a competitive virus ACE2-binding inhibitor. […] We propose the use of bromhexine as a prophylactic and treatment. […] We encourage the scientific community to assess bromhexine clinically as a prophylactic and curative treatment. | 2020-05-29 |
| 32458279 | We suggest that a combination of an IV and pulmonary delivery dose regimen should be studied immediately to realize a potentially more effective antiviral therapy against COVID-19. | 2020-05-29 |
| 32458356 | The early stages of the COVID-19 pandemic have focused on containing SARS-CoV-2 infection and identifying treatment strategies. […] Many countries have made changes to routine management of NCD patients, e.g., cancelling non-urgent outpatient visits, which will have important implications for NCD management, diagnosis of new-onset NCDs, medication adherence, and NCD progression. | 2020-05-29 |
| 32458370 | This article discusses a stepwise algorithm for the management of outpatient warfarin therapy. […] Alternative management strategies are presented and discussed, including alternative pharmacological therapy options and self-monitoring. […] Our algorithm aims to help clinicians safely optimize the treatment of patients requiring anticoagulation therapy in the context of the global response to the current pandemic. | 2020-05-29 |
| 32458488 | The Colombian government has approved the use of CQ for COVID-19, a measure that could negatively impact a large number of patients who depend on this drug for the treatment of other life-threatening diseases such as malaria and rheumatic autoimmune diseases. | 2020-05-27 |
| 32458502 | These prescriptions are however neither specific nor highly effective for COVID-19 treatment. […] This patient went through severe COVID-19 but eventually recovered upon the implementation of this treatment regimen, suggesting potential therapeutic effects of diammonium glycyrrhizinate as alternative medicine to help relieve COVID-19 symptoms. | 2020-05-27 |
| 32458530 | Patients, who will be started on immunosuppressive therapy, should be tested for Covid-19 prior to the therapy, and in the event that Covid-19 is suspected, the therapy should be discontinued. | 2020-05-27 |
| 32458536 | Psoriasis and atopic dermatitis are common, chronic, inflammatory skin conditions, with immune dysregulation as a shared mechanism; therefore, mainstays of treatment include systemic immunomodulating therapies. […] Without definitive COVID-19 data, these recommendations may be useful in guiding treatment of psoriasis and atopic dermatitis patients during the COVID-19 pandemic. | 2020-05-27 |
| 32458588 | During remote-visits several interventions were conducted: triage for COVID-19 suspected symptoms, email check of clinical pictures and of laboratory examinations, advices for topical and systemic therapy continuation or discontinuation/switch and re-schedule of next appointment. […] Our real-life experience shows that remote monitoring was effective in preventing unnecessary worsening of severe chronic skin diseases and poor outcomes due to withdrawal of current therapy. | 2020-05-27 |
| 32458596 | Medical care decision should be balanced between controlling COVID-19 pandemic spread and timely diagnosis and treatment for gynecologic oncology patients. | 2020-05-27 |
| 32458597 | COVID-19 threatens to curtail patient access to evidence-based treatment. | 2020-05-27 |
| 32458599 | In addition to the treatment of patients with COVID-19, the China Medical Treatment Expert Group for COVID-19 is active to study and screen effective antiviral drugs, and has found that chloroquine, an old antimalarial,shows activity against SARS-CoV-2. […] Then, chloroquine was included in the Guidelines for the Diagnosis and Treatment of COVID-19 in China (version 6) issued by National Health Commission of the People’s Republic of China. […] This paper summarizes the currently available data and experiences from clinical treatment for malaria with chloroquine drugs, so as to provide insights into the more rational use of chloroquine agents for the treatment of COVID-19. ［摘要］ 2019 年底, 我国湖北省武汉市出现了新型冠状病毒肺炎 疫情, 随后在全国扩散并成为全球大流行。 | 2020-05-28 |
| 32458694 | Compared with non-ACEI/ARB treatment, ACEI/ARB treatment was not associated with disease severity (OR 0.71, 95 % CI 0.46-1.08, P 0.11, I2 59%) but was related to lower mortality of COVID-19 in patients with hypertension (OR 0.57, 95 % CI 0.38-0.84, P 0.004, I2 0). […] In summary, ACEI/ARB therapy did not aggravate disease severity of COVID-19. […] Besides, ACEI/ARB therapy can decrease the mortality of COVID-19. | 2020-05-27 |
| 32458969 | High-risk patients presenting with progressing symptomatic disease have only hospitalization treatment with its high mortality. […] An outpatient treatment that prevents hospitalization is desperately needed. […] Five studies, including two controlled clinical trials, have demonstrated significant major outpatient treatment efficacy. | 2020-05-27 |
| 32459061 | We report data regarding outpatient visits, multidisciplinary treatment planning conference, surgical caseload, and modifications of oncologic therapy during this pandemic and compared this data to the same interval last year. | 2020-05-29 |
| 32459123 | Finally, we extend these findings to suggest possible treatment options that may merit investigation in randomized clinical trials. | 2020-05-27 |
| 32459144 | It has been suggested that the main protease (Mpro) of SARS-CoV-2 may be an important target to discover pharmaceutical compounds for the therapy of this life-threatening disease. […] Therefore, the present research may provide some meaningful guidance for the prevention and treatment of SARS-CoV-2. | 2020-05-27 |
| 32459192 | The global coronavirus disease 2019 (COVID-19) has presented major challenges for clinical laboratories, from initial diagnosis to patient monitoring and treatment. | 2020-05-27 |
| 32459372 | We review the current knowledge on the interaction between SARS-CoV-2 infection and RAS blockers and suggest a scientific rationale for continuing RAS blockers therapy in patients with COVID-19 infection. | 2020-05-27 |
| 32459529 | To summarize evidence about the benefits and harms of hydroxychloroquine or chloroquine for the treatment or prophylaxis of coronavirus disease 2019 (COVID-19). […] Four randomized controlled trials, 10 cohort studies, and 9 case series assessed treatment effects of the medications, but no studies evaluated prophylaxis. […] Two studies assessed the efficacy of chloroquine; 1 trial, which compared higher-dose (600 mg twice daily for 10 days) with lower-dose (450 mg twice daily on day 1 and once daily for 4 days) therapy, was stopped owing to concern that the higher dose therapy increased lethality and QTc interval prolongation. | 2020-05-27 |
| 32459567 | The purpose of this review is to analyze what is currently known about COVID-19 in regard to the safety of systemic treatment, and to provide guidelines for use in psoriasis during this pandemic. […] The AAD,NPF and IPC are in agreement regarding their recommendation that patients with active COVID-19 infection should discontinue any biologic therapy. […] Patients with active COVID-19 infections should discontinue systemic treatment for psoriasis. […] Patients with risk factors should discuss continuing treatment on a case by case basis. | 2020-05-27 |
| 32459571 | Situations of not working or studying, not having had enough food in the past 12 months, not having a medical prescription to get medication and having had a workplace injury were all significantly associated with higher odds of having unmet healthcare needs. | 2020-05-27 |
| 32459574 | In spite of the relatively high morbidity and mortality, there is no approved medication yet for COVID-19. […] It is of paramount importance to explore some of the available tools that could help accelerate the adoption of any or some of the many proposed modalities for the treatment of diseases. […] In addition to its usefulness when the results of new forms of treatment are quickly needed, other important benefit of sequential analysis includes the ability to reach a similar conclusion about the utility of a new drug without unduly exposing more patients to the side effect of the old drug, in particularly, for the treatment of a rare disease. | 2020-05-27 |
| 32459621 | Both modified formulations met standard requirements for a 3-minute surgical hand preparation, the usual duration of surgical hand treatment in most hospitals in Europe. | 2020-05-27 |
| 32459655 | Due to demographic change and, more recently, the Coronavirus Disease 2019 (COVID-19), the importance of modern intensive care units (ICU) is becoming apparent. […] AI for ICUs would be useful for early detection of complications and increased risk of mortality, as well as to have guidelines for therapy and diagnostics proposed. | 2020-05-27 |
| 32459664 | This has major implications for cancer prevention, management and treatment. | 2020-05-27 |
| 32459790 | Epidemiologic data, previous clinical characteristics, support therapy needed, imaging tests, laboratory observations on admission, and pharmacologic therapy. […] All patients needed oxygen therapy through a nasal cannula; five patients received high-flow nasal cannula therapy, which was later substituted with noninvasive ventilation in four. […] Respiratory symptoms were the leading cause of PICU admission, making respiratory support the principal therapy. | 2020-05-30 |
| 32459919 | In total, 397 patients underwent randomization and began treatment (200 patients for 5 days and 197 for 10 days). […] The median duration of treatment was 5 days (interquartile range, 5 to 5) in the 5-day group and 9 days (interquartile range, 5 to 10) in the 10-day group. | 2020-05-27 |
| 32460184 | Furthermore, timely access to mental healthcare, financial provisions and social/labour support programs, as well as optimal treatment for mental disorders is urgently needed. | 2020-05-29 |
| 32460208 | Unfortunately, to date, there is no specific antiviral treatment for COVID-19. | 2020-05-29 |
| 32460364 | We believe care givers as well as healthcare providers should not withhold necessary medical care since delay in diagnosis and treatment in these routinely seen medical emergencies may become as big of a threat as COVID-19 itself. | 2020-05-27 |
| 32460369 | Although based on existing evidence, NSAIDs have been effective in treating respiratory infections caused by influenza and rhinovirus, since there is no clinical trial on COVID-19 and case-reports and clinical experiences are indicative of elongation of treatment duration and exacerbation of the clinical course of patients with COVID-19, it is recommended to use substitutes such as acetaminophen for controlling fever and inflammation and be cautious about using NSAIDs in management of COVID-19 patients until there are enough evidence. | 2020-05-27 |
| 32460390 | Data on the clinical course of COVID-19 in immunosuppressed patients are limited and the effective treatment strategy for these patients is unknown. […] Demographic, clinical and treatment data were extracted from the electronic patient files. […] In 57% of patients, the immunosuppressive therapy was not changed and only 3 patients were treated with chloroquine. […] Most patients recovered without experimental anti-viral therapy. | 2020-05-27 |
| 32460417 | The clinical spectrum showed mostly mild symptoms with some patients developing bilateral pneumonia needing partly intensive care treatment and causing death(1). | 2020-05-27 |
| 32460421 | NMSC is predominantly a cancer of the middle aged or elderly and accounts for considerable consulting and treatment time in most radiation oncology departments. […] Many patients also suffer from medical co-morbidity, an important factor in any treatment decision. | 2020-05-27 |
| 32460457 | In Korea, non-hospital facilities called “living and treatment centers (LTCs)” have been established since 5 March 2020. | 2020-05-28 |
| 32460458 | We examined cytopathic effects of virus 48 hours after administration of the respective treatments and measured viral loads at three time points (0, 24, and 48 hours post-treatment) by quantitative real-time reverse-transcription polymerase chain reaction, and compared the results obtained from the different antiviral regimens tested. | 2020-05-28 |
| 32460624 | In addition to the standard of care, an immune-modulatory therapy tailored to each one of the different phenotypes should be used in order to prevent or reduce the release of cytokines responsible for organ damage and disease progression. | 2020-05-28 |
| 32460632 | Antiviral therapy is employed for the burn patient with herpesvirus infections. […] Recognition and antiviral therapy are employed, but additional studies are necessary to improve outcomes in these patients. | 2020-05-28 |
| 32460829 | We report the characteristics and outcome of patients diagnosed with COVID-19 during breast cancer treatment at Institut Curie hospitals (ICH, Paris area, France). […] We found no association between prior radiation therapy fields or extent of radiation therapy sequelae and extent of COVID-19 lung lesions. […] This prospective registry analysis suggests that the COVID-19 mortality rate in breast cancer patients depends more on comorbidities than prior radiation therapy or current anti-cancer treatment. | 2020-05-29 |
| 32460839 | Intravenous infusion of MSCs has shown promising results in COVID-19 treatment. […] The pulmonary function and symptoms of the patient with COVID-19 pneumonia was significantly improved in 2 days after hWJC transplantation, and recovered and discharged in 7 days after treatment. […] After treatment, the percentage and counts of lymphocyte subsets (CD3+, CD4+, and CD8+ T cell) were increased, and the level of IL-6, TNF-α, and C-reactive protein is significantly decreased after hWJC treatment. […] Thus, the intravenous transplantation of hWJCs was safe and effective for the treatment of patients with COVID-19 pneumonia, especially for the patients in a critically severe condition. […] This report highlights the potential of hWJC infusions as an effective treatment for COVID-19 pneumonia. | 2020-05-30 |
| 32460926 | Issues around the assessment and treatment of these patients are examined and distilled into a simple (one-paged guidance resource that can assist clinicians in managing suspected delirium. | 2020-05-28 |
| 32461141 | In this review we will discuss the relative role of the different complement activation products in the pathogenesis of COVID-19-associated tissue inflammation and thrombosis and propose the hypothesis that blockade of the terminal complement pathway may represent a potential therapeutic option for the prevention and treatment of lung and multi-organ damage. | 2020-05-30 |
| 32461198 | The evaluation of the treatment of these comorbidities at baseline and during COVID-19 is scarce and the results are conflicting. […] The aim of this review article was to summarize the prevalence of hypertension and CVD in patients with COVID-19, their influence on the outcome and the effect of treatment of hypertension and CVD in COVID-19 patients. | 2020-05-31 |
| 32461261 | Both of these situations raise challenges for caregivers who are trying to be honest, to deal with their own moral distress, and to provide compassionate palliative care. | 2020-05-28 |
| 32461502 | We still need an effective treatment, an affordable vaccine, or a collective achievement of sufficient immunity (reaching up to 70% of the whole population). | 2020-05-28 |
| 32461973 | Currently, there is no vaccine or approved treatment for this emerging infection; thus, the objective of this study is to design a multiepitope peptide vaccine against COVID-19 using an immunoinformatics approach. | 2020-05-30 |
| 32461981 | As of Feb. 9, 2020, a total of 40,260 patients have been diagnosed with NCP, and 23,589 patients were suspected to have infected by the 2019 novel coronavirus (COVID-19), which puts forward a great challenge for public health and clinical treatment in China. | 2020-05-30 |
| 32462098 | The weak governance in the fragile healthcare system exacerbates the general public’s anxiety as the COVID-19 testing facilities are centered around in the urban areas, a long serial to be tested, minimum or no treatment facilities in the dedicated hospital units for COVID-19 patients are the chief observations hampered along with the disruption of other critical healthcare services. | 2020-05-30 |
| 32462267 | As cardiovascular patients are at high risk but also have dyspnea and fatigue as leading symptoms, prevention, diagnostics and treatment in these patients are important to provide adequate care for those with or without COVID-19 but most importantly when comorbid cardiovascular conditions are present. […] As angiotensin-converting enzyme 2 (ACE2) is regarded as the viral receptor for cell entry and as the Coronavirus is downregulating this enzyme, which provides cardiovascular and pulmonary protection, there is ongoing discussions on whether treatment with cardiovascular drugs, which upregulate the viral receptor ACE2 should be modified. […] As most of the COVID-19 patients have cardiovascular comorbidities like hypertension, diabetes, coronary artery disease and heart failure, which imposes a high risk on these patients, cardiovascular therapy should not be modified or even withdrawn. | 2020-05-30 |
| 32462289 | Patients with diagnosis of cancer and undergoing treatment further represent a population at risk for worsening cardiopulmonary outcomes. […] This review explores specific risk factors, diagnoses, and treatment options that impact cardio-oncologic patients with COVID-19. […] Additionally, elderly cancer patients undergoing recent anti-cancer treatment may be at greater risk for sustaining worse outcomes, although data remains suboptimal in this population. […] Major gaps remain regarding risk associated with type of cancer and type of anti-cancer treatment, as well as the layered risk of cardiovascular disease and cancer. […] Immunomodulatory therapies used to treat cytokine release syndrome secondary to anti-cancer therapies, as well as other agents being traditionally used to treat cardiovascular and cancer disease states, are being investigated for treatment of COVID-19. […] Patients undergoing anti-cancer therapy or those who have suffered from coronavirus infection may develop long-standing changes, not limited to pulmonary fibrosis, hyperlipidemia, and worsening atherosclerosis. […] Those undergoing anti-cancer therapy are at theoretically increased susceptibility for infection, with type of cancer not necessarily dictating outcome. […] A review of the literature of patients with cardiovascular and/or cancer disease is presented, as well as proposed strategies to attenuate risk regarding treatment, management, and surveillance in this vulnerable population. | 2020-05-30 |
| 32462412 | Patients with clinical signs of seizures or otherwise unexplained encephalopathy may benefit from electroencephalography monitoring and/or empiric anti-epileptic therapy. | 2020-05-30 |
| 32462497 | During the pandemic, the most important principles of treatment should be controlling the spread of infection as the first priority, prompt assessment of patient risk, recommending conservative medical therapy rather than invasive interventions, and strict infection control measures to limit infection spread within the hospital and to healthcare workers. | 2020-05-30 |
| 32462545 | Further work is needed to prioritize drugs for investigation in well-controlled clinical trials and treatment protocols. | 2020-05-30 |
| 32462701 | There is therefore an urgent need for development of animal models for improved evaluation of efficacy of drugs identified as having potential in the treatment of severe COVID-19. | 2020-05-28 |
| 32462717 | In order to reduce the cytokine storm, we would like to propose the IL6 receptor antagonist therapy for the COVID-19 patients. […] However, researchers and physicians should look for more IL6 receptor antagonists for the therapy of cytokine storm syndrome SARS-CoV-2 infected persons to enhance the therapeutic options for cytokine storm. | 2020-05-28 |
| 32462719 | In the midst of a worldwide pandemic of the Coronavirus Disease 2019 (COVID-19), a paucity of data precludes derivation of COVID-19-specific recommendations for nutritional therapy. […] Delivery of nutritional therapy must include strategies to reduce exposure and spread of the disease by providing clustered care, adequate protection of healthcare providers, and preservation of personal protective equipment. […] At all times, strategies for nutritional therapy need to be assessed on a risk/benefit basis, paying attention to risk for both the patient and the healthcare provider. | 2020-05-28 |
| 32462756 | Cancer patients are advised to stay at home in case of potential infection, which may cause delays of routine diagnosis and necessary treatment. | 2020-05-28 |
| 32462841 | Obesity represents a higher risk of severe COVID-19 infection, which may lead to the requirement of a mechanical ventilation in intensive care units and premature death. | 2020-05-29 |
| 32462858 | The aim of the multicentre study promoted by Nuova FIO is to evaluate the beneficial effects of the systemic Oxygen-Ozone (O2O3) therapy in patients suffering from SARS COV-2 disease in the early phases of the disease, before worsening, up to the need of tracheal intubation. […] The study is based on the rationale on that the systemic oxygen-ozone treatment could be effective, positively influencing the disease evolution and/or being able to mitigate the onset of the cytokine storm syndrome at least partially. | 2020-05-28 |
| 32462968 | Prior research on nanotechnologies in diagnostics, prevention and treatment of coronavirus infections is reviewed. […] The current absence of antiviral therapeutics that specifically target human coronaviruses, including SARS-CoV-2, might be largely due to the underuse of nanotechnologies. […] Elucidating the interface between nanoparticles and coronaviruses is timely, but presents the only route to the rational design of precisely targeted therapeutics for coronavirus infections. | 2020-05-28 |
| 32462970 | Two drugs Glisoxepide and Idarubicin used for treatment for diabetes and leukemia respectively were selected as stronger binder of EndoU. | 2020-05-28 |
| 32462984 | In order not to compromise treatment of oncology patients, reducing the number of patients with COVID-19 undergoing treatment is mandatory. | 2020-05-28 |
| 32462988 | The treatment for the severe respiratory illness caused by this virus is primarily symptomatic at this point, although the usage of a broad antiviral drug Remdesivir has been allowed on emergency basis by the Food and Drug Administration (FDA). | 2020-05-28 |
| 32463077 | Requiring them to travel to an infusion center, stay in a skilled nursing facility or remain in the hospital longer than necessary to receive treatment results in avoidable risk of exposure amidst a pandemic. | 2020-05-28 |
| 32463204 | Logistical patient data concerning patient numbers, chief complaints, length of stay in the Emergency Department, acuity level, isolation status, and treatment level were analysed. | 2020-05-29 |
| 32463221 | The aim of this Viewpoint is to justify (1) the crucial roles of glutathione in determining individual responsiveness to COVID-19 infection and disease pathogenesis and (2) the feasibility of using glutathione as a means for the treatment and prevention of COVID-19 illness. […] The hypothesis unravels the mysteries of epidemiological data on the risk factors determining serious manifestations of COVID-19 infection and the high risk of death and opens real opportunities for effective treatment and prevention of the disease. | 2020-05-28 |
| 32463289 | The COVID-19 pandemic has caused many Veterans Healthcare Administration providers working with veterans diagnosed with posttraumatic stress disorder to question the feasibility and appropriateness of continuing to provide trauma-focused treatment during this crisis. […] Data from a Veterans Affairs medical center’s posttraumatic stress disorder clinical team suggest that not only are veterans interested in continuing with treatment but also that the treatments can be modified to accommodate the current climate. | 2020-05-28 |
| 32463308 | Chloroquine and hydroxychloroquine were developed in the World War II era for treatment and prophylaxis of malaria, long before modern drug safety surveillance programs. | 2020-05-28 |
| 32463348 | We evaluated baseline and post-medication QT interval (QTc, Bazett’s) using 12-lead ECGs. | 2020-05-28 |
| 32463377 | This paper examines the extent to which Australia, the United Kingdom (UK) and the United States (US) during the two weeks following the pandemic announcement, sought to promote telehealth as a tool that could help identify COVID-19 among older people who may live alone, be frail and/or be self-isolating; and give support or facilitate the treatment of people who are or maybe infected. | 2020-05-28 |
| 32463478 | The treatment of patients with cancer who test positive for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) poses unique challenges. […] In this commentary, the authors describe the ethical rationale and implementation details for the creation of a novel, multidisciplinary treatment prioritization committee, including physicians, frontline staff, an ethicist, and an infectious disease expert. […] The treatment prioritization committee sets a threshold of acceptable harm to patients from decreased cancer control that is justified to reduce risk to staff. […] The creation of an ethical, consistent, and transparent decision-making process involving such frontline stakeholders is essential as departments across the country are faced with decisions regarding the treatment of SARS-CoV-2-positive patients with cancer. | 2020-05-28 |
| 32463545 | A higher need for assisted ventilation beyond pure oxygen support (Invasive Mechanical Ventilation or Non-Invasive Ventilation) and a higher admission to intensive or semi-intensive care units was observed in patients with overweight and obesity (p<0.01 and p < 0.05, respectively) even after adjusting for sex, age and comorbidities (p<0.05 and p<0.001, respectively), or when patients with dementia or advanced cancer were removed from the analysis (p<0.05). […] Patients with overweight and obesity admitted in a medical ward for SARS-CoV-2 related pneumonia, despite their younger age, required more frequently assisted ventilation and access to intensive or semi-intensive care units than normal weight patients. | 2020-05-28 |
| 32463803 | Off-label treatment with tocilizumab restored the cytotoxic potential of NK cells. | 2020-05-28 |
| 32464081 | Finally, surge requirements should address the needs of both those expected to survive and those who will not, by expanding palliative care and other resources for the dying. | 2020-05-29 |
| 32464097 | Without approved antiviral therapeutics or vaccines to this ongoing global threat, type I and type III interferons (IFNs) are currently being evaluated for their efficacy. […] In this review, we describe the recent progress in our understanding of both type I and type III IFN-mediated innate antiviral responses against human coronaviruses and discuss the potential use of IFNs as a treatment strategy for COVID-19. | 2020-05-31 |
| 32464098 | A better understanding of the immune response to SARS-CoV-2 will be critical for the application and development of therapeutics. […] In this review, we discuss what is known about the role of the innate immune system during SARS-CoV-2 infection, suggest directions for future studies, and evaluate proposed COVID-19 immunomodulating therapeutics. | 2020-05-30 |
| 32464333 | To this aim, twelve influent sewage samples, collected between February and April 2020 from Wastewater Treatment Plants in Milan and Rome, were tested adapting, for concentration, the standard WHO procedure for Poliovirus surveillance. | 2020-05-30 |
| 32464584 | In contrast to ablative haematopoietic stem cell therapy, most multiple-sclerosis-related disease modifying therapies do not particularly target the innate immune system and few have any major long-term impact on CD8 T cells to limit protection against COVID-19. | 2020-05-30 |
| 32464585 | As the two previously reported cases of encephalitis associated with this virus were not widely discussed regarding the treatment, we share our successful approach and add some recommendations about this new and scarce entity. | 2020-05-30 |
| 32464624 | This work reviews effective methods of using filtration devices in treatment to reduce the level of various inflammatory mediators and discharge patients from the ICU faster. | 2020-05-28 |
| 32464637 | Therefore, different scientific discovery strategies need to be connected, to generate a rational treatment which can be made available as rapidly as possible. […] The proposed mechanism by which SARS-CoV-2 causes disease immediately suggests a possible treatment, since the AT1R is a key player in this whole process. […] AT1R antagonists appear to be the ideal candidate for the treatment of SARS-CoV-2 infection. […] Therefore, we propose to consider using AT1R antagonists in the treatment of SARS-CoV-2. | 2020-05-28 |
| 32464662 | The coronavirus disease 2019 pandemic has exacerbated staffing challenges already facing critical care nurses in intensive care units. […] Many intensive care units have been understaffed and the majority of nurses working in these units have little experience. | 2020-05-28 |
| 32464670 | For this purpose, an operational concept was developed, consisting of various individual actions, e. g. the reduction of outpatient treatment to emergencies, life-threatening diseases and urgent aftercare, a double triage of patients and the introduction of treatment teams.The newly developed operational concept was successfully implemented within a few days. | 2020-05-28 |
| 32464700 | Most high-income countries are aggressively engaged in the collection and research evaluation of convalescent plasma as a specific passive immunotherapy for treatment of COVID-19. […] Nevertheless, there is an urgent effort in LMIC to provide COVID-19 convalescent plasma as a potentially effective therapy that can be produced locally. | 2020-05-28 |
| 32466136 | The COVID-19 global pandemic is accelerating investigations for effective vaccines and repurposable validated therapeutics […]. | 2020-06-13 |
| 32466458 | A comprehensive strategy, including surveillance, diagnostics, research, clinical treatment, and development of vaccines, is urgently needed to win the battle against COVID-19. | 2020-06-02 |
| 32466536 | Liquid biopsy is considered a revolutionary technique that is opening unexpected perspectives in the early diagnosis and, in therapy monitoring, severe diseases, including cancer, metabolic syndrome, autoimmune, and neurodegenerative disorders. | 2020-05-29 |
| 32466736 | We report our initial experience in the treatment of acute ischemic stroke with LVO in patients with COVID-19. […] Baseline clinical and radiological findings, treatment, and short-term outcomes are reported. | 2020-05-29 |
| 32466738 | To quantify the impact of the pandemic, the number of stroke code activations, ambulance transfers, consultations through telestroke, stroke unit admissions, and reperfusion therapy times and rates are described in temporal relationship with the rising number of COVID-19 cases in the region. […] Time of arrival from symptoms onset to stroke units was delayed >30 minutes, reperfusion therapy cases fell, and door-to-needle time started 16 minutes later than usual. | 2020-05-29 |
| 32467007 | Because treatment options for coronavirus disease 2019 (COVID-19) are very limited, the use of convalescent plasma has bee explored. […] Without effective treatments and with the increased risks of antiviral therapy for the elderly, this patient was given convalescent plasma. […] With the substantial increase of COVID-19 in recent months,treatment for elderly patients has become restricted in some countries. […] The successful treatment of this 100-year-old patient using convalescent plasma suggests that we should consider adding convalescent plasma in th management of the elderly. | 2020-05-31 |
| 32467101 | The pandemic is the cause of significant mortality and with this the need for rapidly disseminated information for palliative care professionals regarding the prevalence of symptoms, their intensity, their resistance or susceptibility to symptom control and the mode of death for patients. | 2020-05-29 |
| 32467359 | Viral inactivation was performed with three different methods: (1) incubation with TRIzol® LS Reagent for 10 min at room temperature, (2) heating in a waterbath at 56°C for 30 min, and (3) high-temperature treatment, including 121°C autoclaving for 20 min, 100°C boiling for 20 min, and 80°C heating for 20 min. […] Compared to the amount of RNA in the original sample, TRIzol treatment destroyed 47.54% of N gene and 39.85% of ORF 1ab. | 2020-05-29 |
| 32467423 | Elucidation of the disease pathogenesis and prospective histopathological studies are crucial for future proper treatment in case of renewed outbreaks. | 2020-06-16 |
| 32467443 | Online search of published medical literature through PubMed using the term “COVID-19,” “SARS,” “acute respiratory distress syndrome,” “coronavirus,” “coagulopathy,” “thrombus,” and “anticoagulants.” Articles were chosen for inclusion based on their relevance to coagulopathy and thrombosis in coronavirus disease 2019, and anticoagulant therapy. | 2020-05-31 |
| 32467751 | Accustomed to fighting cancer with all available means, surgeons are now being asked to delay treatment or make use of alternate strategies to conserve resources. | 2020-06-01 |
| 32467809 | Appendectomy is the gold standard of treatment for acute appendicitis; however, recent evidence suggests conservative management with intravenous antibiotics may provide similar outcomes and can be used as an alternative in selected patients. […] Medical management eliminates the morbidity and mortality associated with surgery but involves significant risks of treatment failures that, in turn, may lead to perforation, peritonitis, and death. […] Our case report illustrates the implementation of successful conservative treatment for acute appendicitis in COVID-19 patients. | 2020-05-29 |
| 32467810 | Management presents its own set of challenges, including but not limited to, deciding whether postponing cancer treatment until the infection resolves is going to benefit the patient and how to organize all aspects of patient care when social contact is as limited as it is for patients newly diagnosed with COVID-19. | 2020-05-29 |
| 32468014 | Despite the very fast and large flow of scientific data on possible treatment solutions, none have yet demonstrated unequivocal clinical utility against coronavirus disease 2019 (COVID‑19). | 2020-05-29 |
| 32468151 | Despite the course of the disease appearing to be mild in many cases, a significant proportion of symptomatic patients develop pneumonia requiring hospitalisation or progress to manifest respiratory complications leading to intensive care treatment. […] In this article, we discuss fresh perspectives and insights into the potential role of immune dysregulation in COVID-19 as well as similarities with systemic inflammatory response in sepsis and the rationale for exploring novel treatment options affecting host immune response. | 2020-05-29 |
| 32468196 | The Benefit-Risk Action Team (BRAT) framework was used to assess the overall benefit-risk of the use of remdesivir as a treatment for COVID-19 compared with standard of care, placebo or other treatments. […] This trial reported fewer serious adverse events in patients taking remdesivir (18%) compared with the placebo group (26%); however, more patients in the remdesivir group discontinued treatment as a result of an adverse event compared with those patients receiving placebo (12% vs 5%). | 2020-05-31 |
| 32468201 | We described some challenges in the orthopaedic department during the epidemic and formulated a set of medical management procedures to find an balance between effective treatment and infection prevention. | 2020-05-29 |
| 32468230 | Many patients with psoriasis on biologic therapy have asked their medical providers about the effect of biologics on COVID-19. […] However, it is currently unknown how biologic therapy for psoriasis might impact patients with psoriasis and COVID-19. […] In this article, we report on the clinical course of two patients on biologic medication for psoriasis who developed COVID-19 and successfully recovered from SARS-CoV-2 infection. […] While more research is needed, it is reassuring to know that successful recovery is possible after COVID-19 infection in patients on biologic therapy for psoriasis. | 2020-06-01 |
| 32468411 | Furthermore, conventional therapeutics for asthma, including inhaled corticosteroids, allergen immunotherapy (AIT), and anti-IgE monoclonal antibody, might also reduce the risks of asthmatics suffering infection of the virus through alleviating inflammation or enhancing antiviral defense. | 2020-05-29 |
| 32468413 | There is no randomized controlled trial that demonstrated the efficacy of antiviral therapy against COVID-19 yet. | 2020-05-29 |
| 32468425 | There is no approved drug for the definitive treatment of the disease. […] Various drugs are being tried for the treatment of COVID-19, including hydroxychloroquine (HCQ). […] Some of the other studies showed negative results with HCQ therapy along with the risk of adverse reactions. […] Stronger evidence from well-designed robust randomized clinical trials is required before conclusively determining the role of HCQ in the treatment of COVID-19. | 2020-05-31 |
| 32468851 | Immunotherapy restores immunological activity against cancer cells and it has become a standard treatment for several cancers. | 2020-05-29 |
| 32469074 | A variety of trials are in development and underway to examine potential interventions for the treatment and prophylaxis of novel coronavirus disease 2019 (COVID-19). | 2020-05-29 |
| 32469164 | Patients with lung cancer are highly susceptible to infection compared to healthy individuals because of systemic immunosuppression induced by malignancy and anticancer therapy. […] Furthermore, the routine treatment of patients with cancer has been affected during the COVID-19 pandemic, and patients may not have been able to undergo timely and effective antitumor treatment, thereby indicating a poor prognosis. | 2020-06-12 |
| 32469189 | Further treatment decisions were made based on the interview and available documentation. | 2020-05-29 |
| 32469265 | With the help of various computational methods, we have re-explored the potential role of both of these antiviral drugs for the treatment of Covid-19 patients by comparing the efficacy of both of the drugs to bind to S-protein at its host receptor region. | 2020-05-29 |
| 32469301 | No treatment has been approved for COVID-19. […] We previously proposed targets that can serve as binding sites for antiviral drugs for multiple coronaviruses, and here we set out to find current drugs that can be repurposed as COVID-19 therapeutics.Aim. To identify drugs against COVID-19, we performed an in silico virtual screen with the US Food and Drug Administration (FDA)-approved drugs targeting the RNA-dependent RNA polymerase (RdRP), a critical enzyme for coronavirus replication.Methodology. Initially, no RdRP structure of SARS-CoV-2 was available. | 2020-05-29 |
| 32469387 | Recognition and understanding of the range of neurological disorders associated with COVID-19 may lead to improved clinical outcomes and better treatment algorithms. | 2020-05-29 |
| 32469614 | All were taking antiretroviral therapy (ART) with CD4 count >200 cells/mm3 and suppressed HIV viral loads at the time of COVID-19 diagnosis. | 2020-05-29 |
| 32469844 | Both international and national data show that telemedicine can play a major role in the triage process, early identification, diagnosis and treatment of infected individuals, and management of patient pathways in a way that ensures the medical team does not come into contact with potentially infected patients. | 2020-06-02 |
| 32470046 | Exposure to treatment with riboflavin and ultraviolet light (R + UV) reduces blood-borne pathogens while maintaining blood product quality. […] SARS-CoV-2 (isolate USA-WA1/2020) was used to inoculate plasma and whole blood units that then underwent treatment with riboflavin and UV light (Mirasol Pathogen Reduction Technology System, Terumo BCT, Lakewood, CO). […] The infectious titers of SARS-CoV-2 in the samples before and after R + UV treatment were determined by plaque assay on Vero E6 cells. […] Each plasma pool (n = 9) underwent R + UV treatment performed in triplicate using individual units of plasma and then repeated using individual whole blood donations (n = 3). | 2020-05-29 |
| 32470151 | Should trained immunity be proven to be involved in timely immune responsiveness against SARS-CoV-2 and that adaptive memory could be detrimental, both treatment regimens and vaccine design will tremendously change accordingly with more focus on upper respiratory tissue innate immunity to subdue this threat underway. | 2020-05-29 |
| 32470153 | The characteristics of interleukin (IL)-1β, IL-2 receptor (IL-2R), IL-6, IL-8, IL-10, tumor necrosis factor (TNF)-α, C-reactive protein (CRP), serum ferritin and procalcitonin (PCT), and lymphocyte subsets of these patients were retrospectively compared before and after treatment. […] Before treatment, there was no significant difference in most inflammatory factors (IL-1β, IL-2R, IL-6, IL-8, IL-10, CRP and serum ferritin) between male and female patients. […] Levels of IL-2R, IL-6, TNF-α and CRP decreased significantly after treatment, followed by IL-8, IL-10 and PCT. […] Serum Ferritin was increased in all patients before treatment, but did not decrease significantly after treatment. […] IL-1β was normal in most patients before treatment. […] Analysis of lymphocyte subsets showed that CD4+ and particularly CD8+ T lymphocytes increased significantly after treatment. […] However, B lymphocytes and natural killer cells showed no significant changes after treatment. | 2020-05-29 |
| 32470212 | We appreciate the article’s suggestions on protection in ophthalmic diagnosis and treatment, but believe that the data and conclusions in meta-analysis need further study. | 2020-05-29 |
| 32470470 | Current treatment of COVID-19 patients relies mainly on antiviral drugs lopinavir/ritonavir, arbidol, and remdesivir, the anti-malarial drugs hydroxychloroquine and chloroquine, and traditional Chinese medicine. […] Given the rapid growth of the SARS-CoV-2-positive population worldwide, ready-to-use CatL inhibitors should be explored as a treatment option. […] We provide evidence that supports the combined use of serine protease and CatL inhibitors as a possibly safer and more effective therapy than other available therapeutics to block coronavirus host cell entry and intracellular replication, without compromising the immune system. | 2020-06-13 |
| 32470486 | Forty-three patients were randomly assigned (1:1) to receive ruxolitinib plus SoC treatment (22 patients) or placebo based on SoC treatment (21 patients). […] Treatment with ruxolitinib plus SoC was not associated with significantly accelerated clinical improvement in severe patients with COVID-19, although ruxolitinib recipients had a numerically faster clinical improvement. | 2020-05-31 |
| 32470515 | Median time of Ramipril treatment was 6 months [IQR:2.9-11.4]. […] This analysis supports the maintenance of RAAS-inhibitor treatment during COVID-19 crisis. | 2020-05-31 |
| 32470547 | Thus, the review aimed to shed light on the potential beneficial effects of NEP pathways as a novel target for COVID-19 therapy by summarizing its possible molecular mechanisms. […] Additional experimental and clinical studies explaining more the relationships between NEP and COVID-19 will greatly benefit in designing the future treatment approaches. | 2020-06-28 |
| 32470602 | No effective treatment for COVID-19 has been well established yet. […] We report three cases of COVID-19 pneumonia who progressed while using antiviral drugs and needed supplementary oxygen therapy, improved after treatment with nafamostat. […] These preliminary findings show the possibility that Nafamostat can be considered to be used in elderly patients with COVID-19 pneumonia who need oxygen therapy. | 2020-06-01 |
| 32470751 | Vaccines for this deadly virus are currently under development and many drugs used for other indications have been repurposed and investigated for prophylaxis and treatment of COVID 19. […] As per SOLIDARITY trial by WHO, some of the most promising candidates include chloroquine phosphate and hydroxychloroquine which are anti-malarial medications, Remdesivir, Lopinavir-Ritonavir combination with or without interferon which are anti-HIV drugs and convalescent plasma therapy. […] The situation is still evolving and hence there is yet no definitive therapy but to conclude the use of repurposed medications can be a boon till a definitive therapy and vaccines are developed. | 2020-05-29 |
| 32470851 | Receptor-mediated uptake of oxLDL by the monocyte-derived macrophages activates the long-term epigenetic reprogramming of innate immunity, which is termed “trained immunity.” The aim of this work is to investigate the mechanisms and treatment possibilities that can control the activities of these specific macrophages. | 2020-06-09 |
| 32470888 | According to our model, this method would prevent a second peak and the number of intensive care units needed per day would be within the threshold of those currently available. | 2020-05-29 |
| 32470889 | The analysis unravel various amino acid mutations in the viral proteins which may provide an explanation for varying treatment efficacies of different inhibitory drugs and a future direction towards a combinatorial treatment therapies based on the kind of mutation in the viral genome. | 2020-05-29 |
| 32471001 | The main treatment combination was hydroxychloroquine and azithromycin. | 2020-05-29 |
| 32471012 | In brief, any kind of surgical treatment should be scrutinized and postponed if possible. […] Nonoperative conservative treatment including pharmacological therapies for hormone-sensitive pathologies should be implemented. | 2020-06-16 |
| 32471115 | Remarkably, the analysis of the current knowledge of the different GPCRs of the RAS molecular system not only confirms that AT1R could be considered a drug target and that its inhibition by losartan and candesartan could be useful in the treatment of BC, but also identifies Mas-related GPCR member D (MRGD) as a druggable protein. […] Overall, the RAS of GPCRs offers multifaceted opportunities for the development of additional compounds for the treatment of BC. | 2020-05-30 |
| 32471171 | Excess ascorbate (as expected in intravenous treatment proposed for COVID-19 management, for example) oxidizes and/or degrades hemoglobin and albumin, as evidenced by UV-vis spectroscopy, gel electrophoresis, and mass spectrometry. | 2020-05-30 |
| 32471203 | As SARS-CoV-2 can be transmitted through droplets and aerosols, we cannot ignore the risk of transmission during hyperbaric oxygen therapy (HBOT). […] Our hyperbaric oxygen therapy center prioritizes preventing the spread of COVID-19 and maintaining operation for the patients during the pandemic. […] The aim of this article is to share the protocol that we have adopted in our hyperbaric oxygen therapy center to help prevent the spread of COVID-19. | 2020-05-30 |
| 32471205 | Since the outbreak of the COVID-19 pandemic in December 2019 and its rapid spread worldwide, the scientific community has been under pressure to react and make progress in the development of an effective treatment against the virus responsible for the disease. | 2020-05-30 |
| 32471274 | Currently operating in seven countries, the trial had 126 participants on treatment and 312 additional participants in active follow up as of March 31, 2020. […] Areas of particular concern during this global emergency include treatment continuity, supply chain management and participant safety monitoring. | 2020-05-30 |
| 32471278 | At present, there is no vaccine or effective standard treatment for severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection (or coronavirus disease-19 (COVID-19)), which frequently leads to lethal pulmonary inflammatory responses. […] Its anti-inflammatory and antiviral activities, in particular, could likely have utility in multimodal therapies for the treatment of ALI/ARDS in COVID-19 patients. | 2020-05-30 |
| 32471812 | In light of the COVID-19 pandemic, many healthcare systems are experiencing an increased demand for palliative care (PC). | 2020-05-30 |
| 32471876 | Additional mortality risk factors may include age, performance status, treatment with chemotherapy, and exposure to hydroxychloroquine plus azithromycin. | 2020-05-30 |
| 32471884 | To characterize patients with coronavirus disease 2019 (covid-19) in a large New York City medical center and describe their clinical course across the emergency department, hospital wards, and intensive care units. […] Of the first 1000 patients, 150 presented to the emergency department, 614 were admitted to hospital (not intensive care units), and 236 were admitted or transferred to intensive care units. […] Patients in hospital, particularly those treated in intensive care units, often had baseline comorbidities including hypertension, diabetes, and obesity. […] Patients admitted to intensive care units were older, predominantly male (158/236, 66.9%), and had long lengths of stay (median 23 days, interquartile range 12-32 days); 78.0% (184/236) developed acute kidney injury and 35.2% (83/236) needed dialysis. | 2020-05-30 |
| 32472138 | All patients were on antiretroviral therapy and virologically suppressed at the time of admission. | 2020-05-30 |
| 32472191 | In univariate analysis, characteristics prior to admission significantly associated with the primary outcome were sex, BMI and previous treatment with renin-angiotensin-aldosterone system (RAAS) blockers, but not age, type of diabetes, HbA1c, diabetic complications or glucose-lowering therapies. | 2020-05-30 |
| 32472216 | They have to weigh risk and benefit of giving cancer treatment vs chances of getting them infected with COVID-19. | 2020-05-30 |
| 32472231 | This inevitably undermined the right to healthcare of many who now faced great difficulty in getting treatment, especially those with cancer or other life-threatening issues. | 2020-05-30 |
| 32472454 | All units suffered personnel shortages and difficulties in enrolling patients, treatment continuity, or performing trial assessments. | 2020-05-30 |
| 32472459 | No current targeted treatment is yet available for COVID-19, an unknown disease up to 2 months ago, which challenges doctors and researchers to find new drugs or reallocate other treatments for these patients. […] Antivirals, antimalarials, corticosteroids, biotechnological and small molecules, convalescent plasma and anticoagulants are among the drugs proposed for the treatment or in tested for COVID-19. […] Sharing and integrating knowledge between specialists, to evaluate the correct timing and setting of every treatment, could greatly benefit our patients. […] We reviewed the literature, combining it with our experiences and our specialist knowledge, to propose a management algorithm, correlating the clinical features with laboratory and imaging findings to establish the right timing for each treatment.Key Points• Critically ill COVID-19 patients show signs of cytokine storm syndrome. […] • No current targeted therapy is available, but a lot of drugs are in tested. […] • Choosing the correct timing of treatment is of pivotal importance to avoid the most severe complications. | 2020-05-30 |
| 32472461 | The authors also review anti-rheumatic drugs while studying COVID-19 treatment. | 2020-05-30 |
| 32472464 | The use of taxis in emergency inguinal hernia is a useful first line of treatment in areas or situations where surgical care is not immediately available, including the COVID-19 pandemic. | 2020-05-30 |
| 32472653 | Cell therapy with mesenchymal stromal cells (MSCs) is a potential treatment for COVID-19 ARDS based on preclinical and clinical studies supporting the concept that MSCs modulate the inflammatory and remodeling processes and restore alveolo-capillary barriers. […] The authors performed a systematic literature review and random-effects meta-analysis to determine the potential value of MSC therapy for treating COVID-19-infected patients with ARDS. | 2020-05-30 |
| 32472655 | Although several antiviral drugs are widely tested, none of them has been approved as specific antiviral therapy for coronavirus disease 2019 (COVID-19). […] Based on the evidence of the significant role of IL-6 in cytokine storm, diabetes mellitus and cardiovascular diseases as principal comorbidities, it seems that anti-cytokine therapy may be useful in patients with severe COVID-19 to reduce mortality. | 2020-05-30 |
| 32472827 | Complications on the intensive care units include acute respiratory distress syndrome, acute cardiac, and kidney injury as well as shock. […] Here, we present the first case report of a successful treatment of a COVID-19 patient presenting with adult respiratory distress syndrome plus refractory combined cardiogenic and vasoplegic shock, which could be successfully stabilized after implantation of a percutaneous ventricular assist device plus an extracorporeal membrane oxygenation. […] Although such intense treatment might not be feasible in case of a health care disaster as described for the hot spots of the COVID-19 pandemic, it might encourage treatment of younger patients on intensive care units not overcrowded by critically ill patients. | 2020-05-30 |
| 32472897 | OMFS should be able to identify a suspected case of COVID-19, its symptoms, risk groups, disease severity, laboratorial and computed tomography alterations, and treatment guidelines. […] A total of 142 OMFS replied the survey and the results brings light to an incomparable health public problem that the OMFS in Brazil are no able to protect itself, diagnose the suspicious and probable cases, request and interpret the correct laboratorial examinations for the treatment of the COVID-19 patients. | 2020-05-30 |
| 32472989 | In the last few days, much confusion has appeared about the management of therapy with angiotensin converting enzyme inhibitors (ACE-i) and angiotensin receptor blockers (ARBs) in infected patients and in those at risk of critical illness in case of infection. | 2020-05-30 |
| 32472991 | Clinical management involves the intensive care approach with intubation and mechanical ventilation in the most serious cases and drug therapy with several apparently promising old and new molecules. | 2020-05-30 |
| 32473020 | Around the world, several dose regimens of hydroxychloroquine have been used for COVID-19 infection treatment, with the objective of identifying a short-term course. | 2020-05-30 |
| 32473070 | This is a scoping review, in which all related articles on COVID-19 and the probable benefits of Pentoxifylline against COVID-19 pathogenesis, in Medline, Scopus, Web of Sciences and Google Scholar up to March 20, 2020 with proper keywords including: pentoxifylline, Pentoxil, COVID-19, coronavirus, treatment, anti-inflammatory, immunomodulatory, anti-fibrosis, oxygenation, circulation, bronchodilator, ARDS and organ failure. […] The antiviral, anti-inflammatory, anti-oxidative, immune-modulatory, bronchodilator and respiratory supportive effects and protective roles in organ failures of PTX, along with its main functions means better circulation-oxygenation properties, low price and safety, make it a promising drug to be considered for covid-19 treatment, especially as an adjuvant therapy in combination with other drugs. | 2020-05-30 |
| 32473109 | Convalescent plasma therapy has been used with varying degrees of success to treat severe microbial infections for more than 100 years. […] The data indicate that administration of convalescent plasma is a safe treatment option for those with severe COVID-19 disease. | 2020-05-30 |
| 32473124 | Management of these patients should include treatment to target these pathological mechanisms. | 2020-05-30 |
| 32473179 | Physical and chemical methods of decontamination have been tested for treatment of FFRs with ultraviolet germicidal irradiation, sterilization by steam, ethylene oxide and vaporous hydrogen peroxide, demonstrating the most promising results thus far. […] The performance of the filter, especially the efficiency of particle penetration following treatment, varied greatly depending on the processing method as well as the model of the filter itself, however. | 2020-05-30 |
| 32473230 | No specific treatment against SARS-CoV-2 is available after 6 months of COVID-19 worldwide outbreak Antivirals could decrease the viral load and reduce direct and indirect damages of SARSCoV-2 infection Ritonavir-bosted lopinavir is effective against SARS-CoV-2 in vitro Sequential virological and pharmacological monitoring helped to understand the efficacy of ritonavir-boosted lopinavir in a SARS-CoV-2 infected patient Ritonavir-boosted lopinavir could be proposed as early treatment for SARS-CoV-2 infection. | 2020-05-30 |
| 32473390 | This rapid pathogenic virus plays an important role in finding the pathogenic virus, treatment and prevention of pandemics. | 2020-05-30 |
| 32473418 | Only, some signals suggest that people taking an immunosuppressive dose of corticosteroid therapy are at greater risk of developing severe COVID-19. | 2020-05-30 |
| 32473509 | Given the fact that Zinc Iodide has been used as an oral antiseptic agent and DMSO has been already proven as a safe pharmaceutical solvent and therapeutic agent, we hypothesize that the combination of these two agents can be applied as an effective, safe and inexpensive treatment for SARS-CoV-2 and other viral infection. […] The therapeutic compound can be applied as both etiological and pathogenesis therapy and used as an effective and safe antiseptic (disinfectant) for human and animals as well. | 2020-05-30 |
| 32473600 | Baricitinib, is an oral Janus kinase (JAK)1/JAK2 inhibitor approved for the treatment of rheumatoid arthritis (RA) that was independently predicted, using artificial intelligence (AI)-algorithms, to be useful for COVID-19 infection via a proposed anti-cytokine effects and as an inhibitor of host cell viral propagation. […] In a case series of patients with bilateral COVID-19 pneumonia, baricitinib treatment was associated with clinical and radiologic recovery, a rapid decline in SARS-CoV-2 viral load, inflammatory markers, and IL-6 levels. | 2020-05-30 |
| 32473607 | Patients with severe liver injury had a more severe clinical course, including higher rates of ICU admission (69%), intubation (65%), renal replacement therapy (33%), and mortality (42%). […] In multivariable analysis, peak ALT was significantly associated with death or discharge to hospice (OR 1.14, p=0.044), controlling for age, body mass index, diabetes, hypertension, intubation, and renal replacement therapy. | 2020-05-30 |
| 32473657 | Generally, they should receive the same treatment approach applied to the general population. | 2020-06-03 |
| 32473681 | We collected data on baseline clinical conditions, medications, cancer diagnosis and treatment, and COVID-19 disease course. […] The most prevalent malignancies were breast (191 [21%]) and prostate (152 [16%]). 366 (39%) patients were on active anticancer treatment, and 396 (43%) had active (measurable) cancer. […] In logistic regression analysis, independent factors associated with increased 30-day mortality, after partial adjustment, were: increased age (per 10 years; partially adjusted odds ratio 1·84, 95% CI 1·53-2·21), male sex (1·63, 1·07-2·48), smoking status (former smoker vs never smoked: 1·60, 1·03-2·47), number of comorbidities (two vs none: 4·50, 1·33-15·28), Eastern Cooperative Oncology Group performance status of 2 or higher (status of 2 vs 0 or 1: 3·89, 2·11-7·18), active cancer (progressing vs remission: 5·20, 2·77-9·77), and receipt of azithromycin plus hydroxychloroquine (vs treatment with neither: 2·93, 1·79-4·79; confounding by indication cannot be excluded). […] Race and ethnicity, obesity status, cancer type, type of anticancer therapy, and recent surgery were not associated with mortality. | 2020-06-23 |
| 32473682 | This conjecture has considerable effect on the treatment of patients with cancer and data from large, multicentre studies to support this assumption are scarce because of the contingencies of the pandemic. […] We found no significant effect on mortality for patients with immunotherapy, hormonal therapy, targeted therapy, radiotherapy use within the past 4 weeks. […] We are not able to identify evidence that cancer patients on cytotoxic chemotherapy or other anticancer treatment are at an increased risk of mortality from COVID-19 disease compared with those not on active treatment. | 2020-06-23 |
| 32473756 | NMS was suspected, and supportive therapy was initiated. | 2020-06-05 |
| 32473781 | Taken together, this has the potential to adversely impact the ability of practitioners and patients to adhere to treatment guidelines for the prevention of recurrent cardiovascular events. | 2020-06-04 |
| 32474009 | Despite intense research efforts worldwide, an effective vaccine and viable treatment options have eluded investigators. […] Therefore, infection prevention, early viral detection and identification of successful treatment protocols provide the best approach in controlling disease spread. | 2020-06-28 |
| 32474026 | Till date, no drug has been approved for the treatment of this infection. […] A number of medications have been proposed and there are ongoing clinical trials around the world to find a suitable treatment. | 2020-06-05 |
| 32474087 | The aim of the present study was to describe the prevalence of pre-admission antithrombotic therapies in patients with COVID-19 and to investigate the potential association between antithrombotic therapy and ARDS, as disease clinical presentation, or in-hospital mortality. […] Pre-admission antithrombotic therapy, both antiplatelet and anticoagulant, does not seem to show a protective effect in severe forms of COVID-19 with ARDS at presentation and rapidly evolving toward death. | 2020-06-28 |
| 32474101 | All staff assigned in the non-COVID treatment unit should be clothed in level 1 personal protective equipment. | 2020-06-02 |
| 32474129 | Within our department, a multidisciplinary tracer team prospectively monitored all patients under investigation, tracking their test status, treatment delays, clinical outcomes, employee exposures, and quarantines. […] As the median turnaround time for RT-PCR testing decreased from 1.5 (IQR: 1-4) to ≤1-day (P < 0.001), the median treatment delay also decreased from 3.5 (IQR: 1.75-5) to 1 business day (IQR: 1-2) [P < 0.001]. […] Active tracking, rapid diagnosis, and aggressive source control can mitigate the adverse effects on treatment delays, workforce incapacitation, and ideally outcomes. | 2020-06-26 |
| 32474476 | Given the lack of antiviral therapies or vaccines for the disease, the antimalarial drug hydroxychloroquine (HCQ) obtained much attention as a treatment for COVID-19. […] However, there are limited and uncertain clinical data to support the beneficial effect of this drug in COVID-19 treatment. […] However, further well-designed studies that would address the optimal dose, duration of treatment, possible side effects, and long-term usage outcomes are needed to make the final decision. | 2020-05-31 |
| 32474479 | Older patients with severe illness during treatment were more prone to develop fibrosis according to thin-section CT results. | 2020-06-19 |
| 32474523 | These recommendations summarize the preventive measures and management of tumor ablation treatment in medical institutions, including outpatient clinics, oncology wards, ablation operation room, and postablation follow-ups in accordance with the guidelines and protocols imposed by the National Health Commission of the People’s Republic of China and the experience in management and prevention according to various hospitals. | 2020-06-04 |
| 32474561 | Careful nursing, observation, and systemic treatment are very important in elderly patients. | 2020-05-31 |
| 32474629 | • Medial or parahilar area involvement and degree of lung involvement were more serious in the deceased patients when compared with those who recovered from treatment. | 2020-06-03 |
| 32474631 | Univariate analysis demonstrated that older age, therapy, presence of fever, presence of hypertension, decreased lymphocyte count, and increased CRP levels were significant parameters associated with an increased risk for class 2. […] • Older age, therapy, presence of fever, presence of hypertension, decreased lymphocyte count, and increased CRP levels were significant parameters with an increased risk for class 2 defined by LCA. | 2020-06-03 |
| 32474718 | The orthopaedic and trauma units have rescheduled their activities to help SARS-CoV-2 units, but trauma patients require also treatment, and no standardized protocols have been established. | 2020-06-03 |
| 32474751 | Thus, a proper arrangement of medication, surgery and radiotherapy for patients with cancer is of vital importance after the epidemic peak. […] Specific patients take priority for chemotherapy treatment. | 2020-06-03 |
| 32474860 | This treatment should be promoted for PEP use and should be the subject of further investigation. | 2020-06-03 |
| 32474883 | • Not switching could have lead to disruption of care or self-medication in a majority of patients. | 2020-06-03 |
| 32474885 | Once, immunologic complications like cytokine storm occur, anti-viral treatment alone is not enough and should be combined with appropriate anti-inflammatory treatment. […] Early recognition and appropriate treatment of immunologic complications will decrease the morbidity and mortality in COVID-19 infection, which requires the collaboration of infectious disease, lung, and intensive care unit specialists with other experts such as immunologists, rheumatologists, and hematologists. | 2020-06-24 |
| 32474891 | Preventing, identifying and treating early VAP can increase the chances of successful treatment in patients with COVID-19. | 2020-06-03 |
| 32475019 | The anti-retroviral drug favipiravir (FPV) has been experimentally used for COVID-19 treatment since March 2020 in Japan. […] Further study is required to determine the optimal strategy for treatment of patients with severe COVID-19. | 2020-06-19 |
| 32475035 | We conducted a systematic review to reveal the contribution of dermatologists in COVID-19 research. 298 articles were included and classified into cutaneous manifestations of COVID-19, operating experience against COVID-19, mechanisms and treatment of COVID-19, disinfection and personal protective equipment(PPE)-related skin diseases and other topics. | 2020-06-19 |
| 32475036 | Real world case series are suggesting a more consistent improvement, and with this additional personal investigation on 48 patients, we signal that 58% of patients achieved Psoriasis Area and Severity Index (PASI) 50, and 19% PASI 75 improvement in the first 8 weeks of treatment. […] Moreover, the observation period includes the Italian outbreak of COVID-19 epidemic, and further information on apremilast safety are provided, no one of the patients having stopped treatment. | 2020-06-24 |
| 32475183 | Lopinavir in combination with ritonavir is approved for the treatment of HIV and has recently been subject to a clinical trial in severe COVID-19. […] After LOTUS China, there is probably no future for lopinavir in the treatment of severe COVID-19, but some clinical trials for prevention or in various stages of COVID-19 have recently started or are ongoing. | 2020-06-12 |
| 32475223 | The present study present multi-way options either by blocking RBD on S proteins or interaction of S protein with ACE2 receptor proteins or inhibiting RdRp to counter any effect of COVID-19 by Plantaricin molecules paving a way that can be useful in the treatment of COVID-19 until some better option will be available.Communicated by Ramaswamy H. | 2020-06-19 |
| 32475230 | Given the high levels of cytokines induced by SARS-CoV-2, treatment to reduce inflammation-related lung damage is critical. | 2020-06-02 |
| 32475347 | Hydroxychloroquine (HCQ) is the standard of care in the treatment of systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), and other inflammatory rheumatic diseases and potentially for the treatment in COVID-19 patients. […] Thus, whole blood samples should be used for HCQ analysis when patients are monitored for HCQ treatment effects. | 2020-06-12 |
| 32475761 | With disease spread outpacing treatment consensus, provider discretion has taken on a heightened role. […] If dexmedetomidine can improve compliance with non-invasive oxygen support (the current recommended first-line therapy) while promoting better oxygenation, it may also decrease the need for mechanical ventilation and thus improve mortality. | 2020-06-13 |
| 32475877 | All patients received either selfquarantined at home or were admitted to hospital for isolated treatment. | 2020-06-01 |
| 32475880 | This study aims to investigate blood and biochemical laboratory findings in patients with severe Corona Virus Disease 2019 (COVID-19) and to develop a joint predictor for predicting the likelihood of severe COVID-19 and its adverse clinical outcomes, to provide more information for treatment. | 2020-06-01 |
| 32476080 | This study investigates the association between the treatment with heparin and mortality in patients admitted with Covid-19. […] The following variables were extracted for this study: age, gender, temperature, and saturation of oxygen on admission, treatment with heparin, hydroxychloroquine, azithromycin, steroids, tocilizumab, a combination of lopinavir with ritonavir, and oseltamivir, together with data on mortality. | 2020-06-04 |
| 32476155 | Here, we evaluated the major impact of COVID-19 on patients with ovarian cancer, discussing the effect of the outbreak on medical and surgical treatment. | 2020-06-19 |
| 32476228 | Retrospective chart reviews were conducted to determine demographic, disease, and treatment information. | 2020-06-19 |
| 32476258 | We describe our institutional experience with COVID-19 among ten SOT patients, including the clinical presentation, treatment modalities, and outcomes of seven renal transplant recipients, one liver transplant recipient, one heart transplant recipient, and one lung transplant recipient. | 2020-06-19 |
| 32476261 | Tocilizumab is an IL-6 receptor antagonist with a record of use for a variety of rheumatologic conditions and cytokine release syndrome due to CAR T-cell therapy but experience in solid organ and composite tissue transplant recipients (SOT/CTTRs) with SARS-CoV-2-related ARDS has not been previously reported in detail. | 2020-06-19 |
| 32476308 | The aim of this review was to summarize the data on the empirical treatment of COVID-19 acquired during this SARS-CoV-2 infection cycle; this would aid the establishment of an appropriate healthcare policy to meet the challenges in the future. | 2020-06-01 |
| 32476380 | However, since Kawasaki and Kawasaki-like diseases present immunodeficiency, treatment with anti-inflammatory/immunosuppressant molecules must be applied very carefully. | 2020-06-09 |
| 32476576 | Taken together, this structure based optimization has provided lead on two natural Mpro inhibitors for further testing and development as therapeutics against human coronavirus.Communicated by Ramaswamy H. | 2020-06-25 |
| 32476586 | While understanding of the unique needs of COVID-19 survivors is developing, components of the evidence-based Transitional Care Model provide a framework for taking a more immediate, holistic response to caring for these individuals as they moved back into the community. […] Evidence generated from rigorous testing of these components reveal the need for federal and state policy solutions to support the following: employment/redeployment of nurses, social workers, and community health workers; training and reimbursement of family caregivers; widespread access to research-based transitional care tools; and coordinated local efforts to address structural barriers to effective transitions. | 2020-06-25 |
| 32476594 | Using these molecular models, we performed virtual screening with our anti-viral, inti-infectious, and anti-protease compounds, which are attractive therapeutics to prevent infection of the COVID-19. | 2020-06-12 |
| 32476644 | They are often recalled to the hospital for treatment and disease surveillance. […] These patients may be immunocompromised due to the underlying malignancy or anti-cancer therapy. | 2020-06-03 |
| 32476793 | This study will analyze the causes of liver injury in COVID-19 and the influence of liver-related complications on the treatment and prognosis of COVID-19. | 2020-06-08 |
| 32477373 | Neurologists are confronted with the question, how they should advise their patients regarding immunosuppressive treatment. […] In particular, the large number of different disease-modifying therapies (DMTs) in the treatment of neuroimmunological diseases such as multiple sclerosis poses a challenge. […] Overall, immunosuppressive therapy does neither seem to have a major impact on infection with SARS- and MERS-CoV nor does it seem to lead to a severe disease course in many cases. | 2020-06-10 |
| 32477419 | Observations reveal that immunosuppressive therapy may have a role in the treatment of this virus, placing emphasis on the scenario of safety through maintenance of therapy with biologic agents, especially when there are no signs or symptoms related to the infection or contact with an infected patient. | 2020-06-04 |
| 32477912 | According to the situation in our city and hospital, an evaluation questionnaire that is suitable for use with children in our hospital has been formulated to achieve the goals of early detection, isolation, diagnosis, and treatment. | 2020-06-04 |
| 32478302 | The superimposed bacterial infection seems not the determinant of clinical outcomes as most patients had a negative evaluation by specific laboratory tests for bacterial infections; got improved dramatically with a short or no antibiotic therapy. | 2020-06-04 |
| 32478445 | Treatment for COVID-19 was either commenced or changed in 87.5% of the patients (n = 7 of 8) on LUS findings. […] Among patients with abnormal LUS findings, treatment was commenced in 5 patients (71.5%) and changed in 2 patients (28.5%). […] One normal and 7 abnormal LUS cases indicate the impact of routine LUS on the clinical outcome and treatment of pregnant women. | 2020-06-19 |
| 32478465 | Only eight serious liver injuries caused by TCZ were reported before being used in the treatment of patients with COVID-19. […] Considering the significantly increased use of TCZ for the treatment of COVID-19, we would like to warn of its rare but possible serious hepatotoxicity, especially when used together with other hepatotoxic drugs. | 2020-06-11 |
| 32478472 | This creates a new dilemma, minimize exposure to patients and health care professionals to COVID-19 while maintaining high quality in cardiovascular therapeutics. […] In order to achieve this, several international recommendations on treatment algorithms modifications and in safety measures in the catheterization room have been published, always aiming to solve this dilemma in the best possible way. […] Hereby, we present a summary of the most recent treatment algorithms in the most important cardiovascular interventions (acute coronary syndromes, structural and congenital heart diseases) as well as specific safety measures with a step-by-step preparedness before and after any interventional procedure during COVID-19 outbreak. | 2020-06-19 |
| 32478544 | To address the mental health challenges, art therapy is offered as a tool to support individuals during periods of isolation. […] Art therapy is a wonderful self-care activity that can benefit individuals throughout the life span. | 2020-06-04 |
| 32478547 | It is argued that cognitive-behavioral therapy, with components of mindfulness, should be part of the therapeutic response. | 2020-06-04 |
| 32478552 | The KCCTP rapidly transitioned to providing accessible information, active outreach, extensive case management, and flexible delivery of teletherapy and online psychosocial support, finding that attending to structural barriers and basic needs was crucial to family engagement and therapeutic success. | 2020-06-04 |
| 32478556 | Implications for the policy and treatment of health care workers facing the COVID-19 crisis are discussed in this commentary. | 2020-06-04 |
| 32478559 | A higher level of vicarious trauma was associated with younger age, less clinical experience, and negative online treatment experiences. | 2020-06-04 |
| 32478709 | Dr Durán is a native of eastern San-tiago de Cuba and his early medical career began in this mountainous re-gion, where he also headed provin-cial prevention and treatment of HIV/AIDS. | 2020-06-09 |
| 32478867 | Physicians must weigh the patient’s risk of COVID-19 complications in the event of exposure against the risk of worse oncologic outcomes from delaying cancer therapy. […] Herein, the authors have summarized current data regarding the risk of COVID-19 complications and mortality based on age and comorbidities and have reviewed the literature assessing how treatment delays affect oncologic outcomes. […] They also have provided multidisciplinary recommendations regarding the timing of local therapy for early-stage skin cancers during this pandemic with input from experts at 11 different institutions. […] For patients with Merkel cell carcinoma, the authors recommend prioritizing treatment, but a short delay can be considered for patients with favorable T1 disease who are at higher risk of COVID-19 complications. […] For patients with melanoma, the authors recommend delaying the treatment of patients with T0 to T1 disease for 3 months if there is no macroscopic residual disease at the time of biopsy. […] Treatment of tumors ≥T2 can be delayed for 3 months if the biopsy margins are negative. […] For patients with cutaneous squamous cell carcinoma, those with Brigham and Women’s Hospital T1 to T2a disease can have their treatment delayed for 2 to 3 months unless there is rapid growth, symptomatic lesions, or the patient is immunocompromised. […] The treatment of tumors ≥T2b should be prioritized, but a 1-month to 2-month delay is unlikely to worsen disease-specific mortality. […] For patients with squamous cell carcinoma in situ and basal cell carcinoma, treatment can be deferred for 3 months unless the individual is highly symptomatic. | 2020-06-19 |
| 32478959 | The results from a small sample size survey conducted in Zhongfaxincheng campuses of Tongji Hospital showed that treatment with topical rh-aFGF could significantly inhibit the progression of pressure sores and accelerate the wound healing with no apparent ill-effects. | 2020-06-19 |
| 32478971 | Current treatment options are summarized. […] Based upon the experience with COVID-19 the following problems are addressed: (a) Can systemic treatment reduce comorbidities of PsA that are also comorbidities for COVID-19? […] Does systemic medical treatment pose an increased risk of infection with SARS-CoV-2? […] Does systemic drug therapy have an impact on the risk of pulmonary fibrosis - a factor with strong negative impact on COVID-19 outcome? […] In non-symptomatic PsA patients, systemic drug therapy can be continued. | 2020-06-19 |
| 32479246 | To date, no specific treatment has been proven to be effective for coronavirus disease 2019 (COVID-19). […] With the rapid increase of infected patients and deaths, it is urgent to explore an effective treatment for COVID-19. […] Given the previous preclinical and clinical studies, MSCs therapy has been shown safety and efficacy in the treatment of respiratory failure or ARDS. […] Based on similar principles, MSCs therapy may also be an effective therapy in the treatment of COVID-19. | 2020-06-01 |
| 32479659 | Bullous pemphigoid (BP) and pemphigus vulgaris (PV) are blistering disorders associated with barrier disruption, immune dysregulation and use of immunosuppressing systemic therapy. […] Patients with BP and PV have higher potential risk factors for infections secondary to skin alterations, comorbidity and chronic treatment with immunosuppressing agents. | 2020-06-19 |
| 32479771 | Understanding risk of deterioration will assist in admission and discharge decisions, and help selection for clinical studies to indicate where risk of therapy-related complications is justified. | 2020-06-12 |
| 32479816 | Rapid diagnostics have been developed, and significant efforts are being made to develop effective vaccines and therapeutics. […] In the absence of any virus-specific therapy, internationally, health care authorities are recommending the adoption of effective community mitigation measures to counter and contain this pandemic virus. | 2020-06-09 |
| 32479829 | Consideration should be given for postponing non-urgent procedures and promoting non-operative treatment to delay or avoid the need for surgery. | 2020-06-04 |
| 32479861 | The coronavirus disease 2019 surge in New York City created an increased demand for palliative care (PC) services. | 2020-06-16 |
| 32479865 | Given the high need and the absence of specific antivirals for treatment of COVID-19 (the disease caused by severe acute respiratory syndrome-associated coronavirus-2 [SARS-CoV-2]), human immunodeficiency virus (HIV) protease inhibitors are being considered as therapeutic alternatives. […] Prezcobix/Rezolsta is a fixed-dose combination of 800 mg of the HIV protease inhibitor darunavir (DRV) and 150 mg cobicistat, a CYP3A4 inhibitor, which is indicated in combination with other antiretroviral agents for the treatment of HIV infection. […] There are currently no definitive data on the safety and efficacy of DRV/cobicistat for the treatment of COVID-19. […] Overall, the data do not support the use of DRV for the treatment of COVID-19. | 2020-06-28 |
| 32479893 | IVM is also a standard treatment against intestinal helminths and ectoparasites given its action as an oral insecticide. | 2020-06-03 |
| 32479900 | Early during the current coronavirus disease 19 (COVID-19) pandemic, hydroxychloroquine (HCQ) received a significant amount of attention as a potential antiviral treatment, such that it became one of the most commonly prescribed medications for COVID-19 patients. | 2020-06-22 |
| 32479911 | Antiepileptic medication failed to achieve seizure control. | 2020-06-27 |
| 32480326 | At first, it was thought that the patients who use immunmodulator therapy could be even at higher risks of disease complications. […] Therefore, several immunmodulators are currently being tested as potential treatment for COVID-19. […] This report supports the idea of using type 1 interferon in the treatment could be effective in COVID-19 affected patients. | 2020-06-24 |
| 32480361 | Recent advancements in wearable sensor technology have shown the feasibility of remote physical therapy at home. […] This study found that a home care system using a commercial smartwatch and ML model can facilitate participation in home training and improve the functional score of the WMFT and shoulder ROM of flexion and internal rotation in the treatment of patients with chronic stroke. […] This strategy can possibly be a cost-effective tool for the home care treatment of stroke survivors in the future. | 2020-06-02 |
| 32480419 | One possibility is to try to publish a disease to death, a therapy strategy first proposed by my late colleague Prof. | 2020-06-19 |
| 32480420 | The SARS-CoV-2-associated disease (COVID-19) is primarily manifested as a respiratory tract infection but may affect and cause complications from multiple organ systems (cardiovascular, gastrointestinal, kidneys, hematopoietic and immune systems) while no proven specific therapy exists. […] Access to health care may be difficult or limited, diagnosis of AL amyloidosis may be delayed with detrimental consequences, treatment administration may need modification. | 2020-06-19 |
| 32481322 | Many reports suggested that psychological intervention is playing a positive role in COVID-19 treatment, but there is no high-quality evidence to prove its effects. […] This paper reports the protocol of a systematic review and meta-analysis to clarify effectiveness of psychological intervention during the treatment of COVID-19. | 2020-06-08 |
| 32481333 | All patients underwent initial and follow-up CT after admission during the treatment, and were divided into 2 groups. | 2020-06-08 |
| 32481340 | Considering the shortage of medical resources and the need to prevent nosocomic infection, the respiratory-treatment strategy in these nonstandard ICUs is different from those in general wards and standard ICUs. […] All patients had oxygen treatment with HFNC, as well as regular treatment of antivirals and traditional Chinese medicine. […] Two patients survived after treatment, while the other two died from acute respiratory distress syndrome (ARDS) and heart failure, respectively. […] This treatment reduced difficulty and workloads for healthcare professionals, had good tolerability for patients, might not significantly increase the risk of infection for healthcare professionals, and do not require additional preventive measures against nosocomic infection. […] HFNC treatment has its advantages in providing oxygen therapy in COVID-19, but healthcare professionals should still pay close attention to changes in patients’ oxygenation rates and respiratory frequency. | 2020-06-08 |
| 32481380 | There is no specific cure for this disease, and the clinical management mainly depends on supportive treatment. […] Our study aims to systematically present the clinical evidence of CHM in the treatment of COVID-19, which will be of guiding significance for further research and clinical practice. | 2020-06-15 |
| 32481381 | On the fifth day after surgery, the patient died despite medical treatment. […] We are the first to report the diagnosis and treatment process of patients with COVID-19 during perioperative period of lobectomy. | 2020-06-15 |
| 32481433 | The study aims to evaluate the effectiveness and safety of acupuncture therapy for coronavirus disease 2019. | 2020-06-15 |
| 32481460 | The systematic review and meta-analysis aims to review and pool current clinical outcomes of QPD combined with antiviral drugs for the treatment of COVID-19. […] This study will provide a high-quality evidence of QPD for the treatment on COVID-19 patients. | 2020-06-15 |
| 32481690 | Similar to SARS and MERS, the lag time in the development of therapeutics is likely to take months to years. | 2020-06-08 |
| 32481719 | We summarize the most up-to-date information on the role of miRNAs in ASL homeostasis and host-pathogen interactions in the airway and discuss concepts for miRNA-directed therapy. | 2020-06-08 |
| 32482077 | The global COVID-19 pandemic has oversaturated many intensive care units to the point of collapse, leading to enormous spikes in death counts. […] Before critical care becomes a necessity, identifying patients who are likely to become critically ill and providing prompt treatment is a strategy to avoid ICU oversaturation. | 2020-06-26 |
| 32482087 | However, these data raise concerns for a potential undertreatment of HF currently that may impact prognosis in the longer term. | 2020-06-22 |
| 32482134 | The two biomarkers readily available in routine laboratories, blood lymphocytes and neutrophil counts, are expected to provide an accurate clinical tool to incline reasonable medication and care because lymphopenia marks immune exhaustion while neutrophilia demonstrates the immunological exuberation. | 2020-06-02 |
| 32482336 | The spread of COVID-19 and its impact on gynecologic oncology care in terms of alterations to normal treatment patterns and anticipated challenges were assessed. | 2020-06-05 |
| 32482348 | There were 44 cases of facial fractures with a tendency for conservative treatment. 19 cases were related to domestic violence or self-harm. | 2020-06-14 |
| 32482483 | Lung ultrasound is well-established as an important means of evaluating lung pathology in patients in the emergency department and in intensive care units. | 2020-06-05 |
| 32482542 | After endoscopic-related operations and antiviral treatment, the patient was subsequently recovered and discharged. | 2020-06-05 |
| 32482571 | This consensus statement about the indications and modalities of corticosteroid treatment in the context of the COVID-19 pandemic was jointly written by experts from the French Association of Otology and Oto-Neurology (AFON) and from the French Society of Otorhinolaryngology, Head and Neck Surgery (SFORL). […] There is currently not enough data in favour of danger or benefit from corticosteroids in COVID-19, so until this matter is resolved it is advisable to limit their indications to the most serious clinical pictures for which it is well established that this type of treatment has a positive impact on the progression of symptoms. […] Corticosteroid therapy is also recommended in cases of sudden hearing loss of more than 60dB, either in the form of intratympanic injections or a week’s course of oral medication. […] In rhinology, there is no indication for systemic corticosteroid therapy in the current situation. […] However, patients are advised to continue with their local corticosteroid therapy in the form of a nasal spray or by inhalation. […] Finally, systemic or local corticosteroid therapy is not indicated for bacterial ENT infections. | 2020-06-05 |
| 32482597 | Tocilizumab (TCZ), a humanized monoclonal antibody targeting the interleukin-6 (IL-6) receptor, has been proposed for the treatment of COVID-19 patients; however, limited data are available on the safety and efficacy. […] We performed a retrospective study on severe COVID-19 patients with hyper-inflammatory features admitted outside intensive care units (ICUs). […] At baseline, all patients were on high-flow supplemental oxygen and most (78% of TCZ patients and 61% of standard treatment patients) were on non-invasive ventilation. […] During the 28-day follow-up, 69% of TCZ patients experienced a clinical improvement compared to 61% of standard treatment patients (p = 0.61). […] Mortality was 15% in the tocilizumab group and 33% in standard treatment group (p = 0.15). […] At day 28, clinical improvement and mortality were not statistically different between tocilizumab and standard treatment patients in our cohort. […] Bacterial or fungal infections were recorded in 13% of tocilizumab patients and in 12% of standard treatment patients. | 2020-06-18 |
| 32482926 | Currently, there is no specific treatment for this virus and the treatment is mainly relied on controlling symptoms. […] Here we discuss our current understanding of SARS-CoV-2 with respect to its receptor recognition and how this knowledge could be useful in treatment using clinically known inhibitory drugs. […] We have also discussed the diagnosis, treatment and preventive measures that are currently being employed for controlling further spread of the virus. | 2020-06-03 |
| 32482971 | Spine patients, however, often need urgent surgery and, moreover, bear an above-average perioperative risk frequently requiring postoperative surveillance on intensive care units (ICUs). | 2020-06-24 |
| 32482977 | Baseline demographics, comorbidities, treatment characteristics, and COVID-related symptomatology were also evaluated. | 2020-06-19 |
| 32483005 | Epidemiological, demographic, clinical, laboratory, treatment, and outcome data were collected and compared. | 2020-06-16 |
| 32483035 | Because of the highly contagious element and easy spread in a communal living arrangement that exists within an inpatient psychiatric hospitals, the following guidelines were established to improve patient and staff safety while still maintaining efficiency and capability to provide this needed treatment to a subgroup of patients. […] The objective of this study was to devise a safe and efficient methodology to deliver potential lifesaving electroconvulsive therapy to inpatients during the coronavirus disease 2019 pandemic. | 2020-06-19 |
| 32483311 | Their demographic data, clinical manifestations, laboratory indicators, and treatment methods were collected and analyzed. | 2020-06-05 |
| 32483409 | There is still no specific antiviral therapy to the current pandemic. […] To fight with COVID-19, National Health and Commission of PRC has recommended some TCM in the guideline, such as HuoxiangZhengqi, LianhuaQingwen ShufengJiedu and XueBijing, and actually displayed a remarkable effect in clinical treatment strategic for COVID-19. […] We review studies to provide an in-depth understanding into the effect of TCM, and also introduce the possible mechanism involved in COVID-19 treatment. | 2020-06-05 |
| 32483428 | While there is currently no specific treatment for COVID-19, several off label drugs approved for other indications are being investigated in clinical trials across the globe. […] In addition, they allow monitoring infectious sides and treatment responses using noninvasive imaging modalities. […] In this article, we have shed light on the promising role of nanoparticles as effective carriers for therapeutics or immune modulators to help in fighting against COVID-19. | 2020-06-12 |
| 32483523 | Two third of therapeutic studies tested Western medicines including antiviral drugs (17.7%), stem cell and cord blood therapy (10.2%), chloroquine and derivatives (8.3%), 16 (6.0%) on Chinese medicines, and 73 (27.4%) on integrated therapy of Western and Chinese medicines. | 2020-06-05 |
| 32483527 | Until now, no definite effective treatment has been identified. | 2020-06-05 |
| 32484159 | This population experiences high mortality from delays in treatment of valve disease but is largely overlapping with the population of highest mortality from COVID-19. […] Areas of innovation to improve our care during this time include increased use of wearable and remote devices to assess patient performance and vital signs, devices for facile cardiac assessment, and widespread use of clinical protocols for expedient discharge with virtual physical therapy and cardiac rehabilitation options. | 2020-06-12 |
| 32484380 | The role of the MDT continues after cancer treatment, if delivered, and the MDT plays an essential role in surveillance and survivorship programs in these challenging times. | 2020-06-02 |
| 32484453 | To evaluate the clinical value of abnormal laboratory results of multiple organs in patients with coronavirus disease 2019 (COVID-2019) and to help clinicians perform correct treatment. | 2020-06-26 |
| 32484735 | In times of emergency, it is crucial that we uphold the safeguards embodied within mental health legislation to prevent prejudicial treatment of mental health consumers. | 2020-06-02 |
| 32484930 | To recognize the period of exaggerated cytokine response in patients with Coronavirus disease 2019 (COVID-19) pneumonia, and to describe the clinical outcomes of using tocilizumab as a treatment option. […] None of them had fever after tocilizumab treatment and the levels of c-reactive protein (13.08±12.89) were almost within normal limits. […] There is currently no proven treatment for COVID-19 induced by novel coronavirus SARS-CoV-2. | 2020-06-19 |
| 32484966 | Some cases rapidly develop deteriorating lung function, which causes deep hypoxaemia and requires urgent treatment. | 2020-06-19 |
| 32485082 | There was no evidence for increased severity of COVID-19 in hospitalised patients on chronic treatment with ACEi or ARB. | 2020-06-03 |
| 32485101 | Targeting brain inflammation may provide significant clues to the treatment of neurologic complications caused by SARS-CoV-2. | 2020-06-26 |
| 32485164 | Overall, this animal model described here provides a useful tool for studying SARS-CoV-2 transmission and pathogenesis and evaluating COVID-19 vaccines and therapeutics. | 2020-06-05 |
| 32485205 | The in vivo efficacy of CQ in the treatment of COVID-19 is currently a matter of debate. […] In the treatment of malaria, CQ impairs the digestion and growth of the parasite by increasing the pH of the food vacuole. | 2020-06-25 |
| 32485289 | Research evaluating the direct neuropsychiatric consequences and the indirect effects on mental health is highly needed to improve treatment, mental health care planning and for preventive measures during potential subsequent pandemics. | 2020-06-25 |
| 32485418 | A higher frequency seems to be present in severely ill patients, in particular those admitted to intensive care units. | 2020-06-24 |
| 32485483 | This has consequences in the treatment of patients and also may lead to underdiagnosing the infection. | 2020-06-23 |
| 32485610 | At the moment, little treatment options are available for Duchenne muscular dystrophy (DMD). | 2020-06-22 |
| 32485619 | Most patients received antiviral, antibiotic, and corticosteroid treatment. | 2020-06-26 |
| 32485858 | In addition, the treatment of javamide-II decreased the phosphorylation of p38 without significant effects on ERK and JNK phosphorylations in the THP-1 cells. | 2020-06-03 |
| 32485875 | Since it has become a global concern, different countries have been working toward the treatment and generation of vaccine, leading to different speculations. | 2020-06-03 |
| 32485894 | DPP-4 inhibitors with anti-viral action may be more useful for infected patients with diabetes, while anti-coagulant treatment is proposed in severe SARS-CoV-2 induced pneumonia. | 2020-06-12 |
| 32485970 | No proven effective antiviral therapy or vaccine currently exists, and supportive care remains to be the cornerstone treatment. | 2020-06-03 |
| 32486364 | In this regard, smart and innovative nano-based technologies and approaches encompassing applications of green nanomedicine, bio-inspired methods, multifunctional bioengineered nanomaterials, and biomimetic drug delivery systems/carriers can help resolve the critical issues regarding detection, prevention, and treatment of viral infections. […] This perspective review expounds recent nanoscience advancements for the detection and treatment of viral infections with focus on coronaviruses and encompasses nano-based formulations and delivery platforms, nanovaccines, and promising methods for clinical diagnosis, especially regarding SARS-CoV-2. | 2020-06-03 |
| 32486469 | This narrative review summarizes current evidence regarding the epidemiology, clinical features, known and presumed pathophysiology-based models, and treatment guidance regarding COVID-19 coagulopathy. | 2020-06-03 |
| 32486488 | Accumulating evidence on NRs’ health benefits has validated its efficiency across numerous animal and human studies for the treatment of a number of cardiovascular, neurodegenerative, and metabolic disorders. […] Here, we summarize currently available data on NR effects on metabolism, and several neurodegenerative and cardiovascular disorders, through to its application as a treatment for specific pathophysiological conditions. […] In addition, we have reviewed newly published research on the application of NR as a potential therapy against infections with several pathogens, including SARS-CoV-2. […] Additionally, to support rapid NR translation to therapeutics, the challenges related to its bioavailability and safety are addressed, together with the advantages of NR to other NAD+ precursors. | 2020-06-15 |
| 32486556 | This article summarized the understanding of the etiology, pathogenesis, epidemiology, clinical characteristics, diagnosis, treatment, rehabilitation, and prevention and control measures of COVID-19 based on the available data and anti-epidemic experience in China. | 2020-06-04 |
| 32486557 | In some epidemiological backgrounds, CT imaging manifestations and evolutionary characteristics are of great significance for early warning of lung injury, assessment of disease severity, and assistance in clinical typing and post-treatment follow-up. 目的： 探讨新型冠状病毒肺炎（COVID-19）临床表现及高分辨率CT（HRCT）影像分型和影像演变特征的临床意义。 | 2020-06-04 |
| 32487159 | Herein, we summarize the virology, epidemiology, clinical manifestations, diagnosis, treatment and prevention of SARS-CoV-2, and hope that countries can control the outbreak as soon as possible to minimize the loss. | 2020-06-17 |
| 32487271 | The drug treatment was mainly symptomatic support therapy, and antibiotics and antiviral drugs were ineffective. | 2020-06-22 |
| 32487513 | Convalescent immune plasma therapy is a promising option as a sort of ‘rescue’ treatment in COVID-19 immune syndrome, where miraculous antiviral drugs are not available yet. […] In this report, we aim to convey our experience of multi-task treatment approach with convalescent immune plasma and anti-cytokine drug combination in a COVID-19 patient with extremely challenging comorbidities including active myeloid malignancy, disseminated tuberculosis and kidney failure. | 2020-06-05 |
| 32487793 | Because of his poor general conditions, he was treated with a double antifungal scheme, although this lies outside the suggested treatment guidelines. […] IPA remains a life-threatening condition, even in immunocompetent hosts, and should therefore always be suspected; if necessary, a combined treatment should rapidly be started. | 2020-06-11 |
| 32487876 | It is crucial to be able to critical appraise the scientific literature, in order to provide adequate nutrition therapy to patients, and in particular, to Covid-19 infected individuals. | 2020-06-16 |
| 32487990 | Hence, early baloxavir treatment may indirectly prevent transmission. […] Here, we estimate impacts of ramping up and accelerating baloxavir treatment on population-level incidence using a new model that links viral load dynamics from clinical trial data to between-host transmission. […] Treatment within 24 h would almost double the impact. […] Consequently, scaling up early baloxavir treatment would substantially reduce influenza morbidity and mortality every year. | 2020-06-04 |
| 32488319 | V.) has developed consensus-based recommendations on surgical treatment of patients with SARS-CoV‑2 infections. | 2020-06-19 |
| 32488413 | Treatment strategies for mental illness include psychotherapy and psychopharmacological interventions. […] The latter are associated with a multitude of adverse drug reactions (ADR); however, they may currently represent the preferred treatment due to restrictions regarding patient care (i.e. social distancing). […] These include respiratory depression, agranulocytosis, intoxication by inhibition of metabolizing enzymes and venous thromboembolism, each of which may be associated with potentially fatal consequences; however, physicians should simultaneously ensure adequate efficacy of treatment, since the ongoing crisis may lead to a worsening of preexisting mental illnesses and to a surge in first onset of psychiatric disorders. | 2020-06-05 |
| 32488422 | Necessary treatment interventions for other patients with critical and life-limiting diseases have been delayed or suspended in order to free resources for the expected COVID-19 patients; however, these people need to feel social connectedness with their relatives. […] Palliative care patients should be exempted from any ban on visitors. […] Families should be able to visit dying patients even on intensive care units or isolation wards, using adequate protective equipment. | 2020-06-05 |
| 32488505 | While underlying mechanisms remain unclear, further investigations are required to target an optimal treatment. | 2020-06-05 |
| 32488564 | In each group, the type of accident, the anatomical location of the injury, and the treatment were reported and compared. | 2020-06-10 |
| 32488861 | Treatment strategies to effectively address COVID-19 and equitably distribute resources are needed, especially in overwhelmed hospitals. | 2020-06-19 |
| 32488888 | After 5-10 days of treatment, levels of Alb and AST in COVID-19 patients were significantly decreased (P < .001 and P = .027, respectively). | 2020-06-19 |
| 32488958 | This study aimed to investigate clinical characteristics, laboratory indexes, treatment regimens, and short-term outcomes of severe and critical coronavirus disease 2019 (COVID-19) patients. […] Post-admission complications, treatment regimens, and clinical outcomes were also documented. | 2020-06-19 |
| 32489022 | In the previous research, our laboratory established a mouse model combining disease with syndrome of human coronavi-rus pneumonia with pestilence attacking the lung syndrome, based on the national traditional Chinese medicine clinical classification of Novel Coronavirus Infected Pneumonia Diagnosis and Treatment Plan. | 2020-06-05 |
| 32489023 | The aim of this paper was to investigate the therapeutic effect of Compound Qinlan Oral Liquid recommended by Provincial Novel Coronary Virus Pneumonia Treatment Scheme on the treatment of BALB/c mice with combining disease with syndrome of human coronavirus pneumonia with pestilence attacking lung syndrome and to explore its clinical application in the treatment of novel coronavirus pneumonia, and to provide laboratory data support for clinical Chinese medicine. […] This model is suitable for simulating traditional Chinese medicine treatment of common disease syndromes in Novel Coronavirus Pneumonia Diagnosis and Treatment program(trial implementation of the sixth edition). | 2020-06-05 |
| 32489024 | According to 2 prescriptions in the Protocol for the diagnosis and treatment of coronavirus disease 2019(7th edition)and 9 prescriptions in Traditional Chinese medicine prescriptions for treating blight, 959 and 1 047 potential ingredients were obtained as the inhibitors of VEGFR and FGFR respectively with the screening thres-hold set as eighty percent of the docking score of the initial ligands. […] To discuss the rule of TCM in the treatment of pulmonary fibrosis, the networks of TCM-channel tropism and TCM-efficacy of the potential herbs was constructed. […] The results of this study are expected to provide references for clinical medication in preventing and treating pulmonary fibrosis caused by COVID-19. | 2020-06-05 |
| 32489025 | This study systematically constructed the molecular networks of different TCM syndromes during the development and progression of COVID-19 and uncovered the biological basis for symptomatic treatment of TCM. […] Furthermore, our data revealed the pharmacological mechanisms and the scientific connotation of recommended prescriptions, which may provide supports for the prevention and treatment of COVID-19 using TCM. | 2020-06-05 |
| 32489027 | This review has summarized the reports on the treatment of viral pneumonia. […] Our paper summarizes the advantages of Chinese patient medicine in the treatment of viral pneumonia, based on which improvements of clinical therapy are expected to be made soon. | 2020-06-05 |
| 32489028 | Physicians usually increase the dosage of Asari Radix et Rhizoma in clinical therapy according to the actual conditions, and there were no adverse reactions. | 2020-06-05 |
| 32489029 | Therefore, under the guidance of the holistic view, syndrome diffe-rentiation of TCM has achieved good effects in the treatment of COVID-19. […] This treatment mainly aimed at eliminating pathogens and strengthening overall health, regulating the balance of body and coordinating various of functions of Zangfu organs. […] In addition, modern medical proposes host-directed therapy(HDT), a strategy aims to interfere with host cell mechanism, enhance immune responses, and reduce exacerbated inflammation. […] To some extent, the combined application of HDT and antiviral therapy is highly consistent with the therapeutic concept of the holistic view of TCM. […] These therapeutic methods and prescriptions intervened with both virus and host at the same time in the treatment of COVID-19, which has important implications for the effective clinical treatment of COVID-19. | 2020-06-05 |
| 32489030 | The analysis and utilization of clinical scientific research data is an effective means to promote the progress of diagnosis and treatment, and a key step in the development of medical sciences. | 2020-06-05 |
| 32489136 | In the light of the global spread of the novel Coronavirus known as COVID-19 and in the absence of an approved treatment and vaccination, Lebanon has taken national measures, among which was home quarantine of the general public in an attempt to flatten the epidemic curve and avoid flooding the health care system. | 2020-06-05 |
| 32489248 | The 3 factors deemed most important for treatment decision-making were■ cancer prognosis and anticipated benefit from treatment,■ risk of treatment toxicity during scarce health care access, and■ patient risk of contracting covid-19. | 2020-06-17 |
| 32489502 | In the current review article, we discussed the epidemiology and etiology of acute kidney injury, management of acute kidney injury including renal replacement therapy options (both hemodialysis and peritoneal dialysis) for inpatient floor, as well as intensive care unit settings. | 2020-06-05 |
| 32489666 | A 55-year-old male COVID-19-positive patient with obstructive sleep apnoea (OSA), diabetes, and obesity presented with cough and shortness of breath, escalating to requiring high-flow oxygen therapy by high-velocity nasal insufflation. | 2020-06-05 |
| 32489692 | These outcomes displayed that intravenous infiltration of MSCs is a safe and efficacy treatment for COVID-19 pneumonia, a severe acute respiratory illness caused by the coronavirus 2 (SARS-CoV-2). […] Only 7 patients were treated, but with extraordinary results, opening a new strategy in COVID-19 therapy. […] The MSCs therapy outcomes reported, are striking, as these cells inhibit the over-activation of the immune system, promoting endogenous repair, by improving the lung microenvironment after the SARS-CoV-2 infection. […] The MSCs could represent an effective, autologous and safe therapy, and therefore, sharing these published results, here is reported the potential use possibilities in COVID-19 of the most common MSCs represented by Adipose Stem Cells (ASCs). | 2020-06-05 |
| 32489694 | Coronavirus disease 2019 (COVID-19) has spread all over the world with high morbidity and mortality rates and there is no specific treatment for this infection. | 2020-06-05 |
| 32489696 | This therapy has been proven in the past to be effective against pneumonitis of diverse etiology and could be used to prevent death of older infected patients. […] Thus, LDRT radiotherapy may be a cost-effective treatment for this frail patient population whom radiation -induced malignancy is not a concern because of their advanced age. | 2020-06-05 |
| 32489698 | At the current stage, due to the lack of effective treatment strategies for COVID-19 innovative approaches need to be considered. | 2020-06-05 |
| 32489711 | After active treatment, increased risk of mortality in patients with preexisting chronic diseases may reduce. | 2020-06-05 |
| 32489724 | Based on the case presented and other cases, understanding the pathways of virus neuroinvasion is necessary to help recognize possible pathologically related consequences of infection and to evaluate new diagnostic and management approaches that will help improve SARS-CoV-2 infection treatment and control. | 2020-06-05 |
| 32489751 | The treatment recommendations include portal pressure reduction strategies including pharmacotherapy with vasoactive agents and beta-blockers and interventional strategies such as transjugular intrahepatic portosystemic shunt placement. | 2020-06-05 |
| 32489928 | The COVID-19 pandemic seriously threatens the lives of the general public and poses momentous challenges to all medical workers, including those engaged in interventional radiology, who play an important role in the diagnosis and treatment of various diseases. […] To further standardize the prevention and control of nosocomial infections and ensure the safety of doctors and patients, the Chinese Society of Interventional Radiology (CSIR) organized multidisciplinary experts in the field of interventional radiology in China to prepare an “Expert Consensus” elaborating and summarizing the protective strategies and suggestions for medical workers in the field of interventional radiology when they engage in interventional diagnosis and treatment activities against the background of novel coronavirus infection control. […] The key points include the following: (I) non-emergency interventional diagnosis and treatment should be suspended while work is ongoing to prevent and control the spread of COVID-19; (II) protective measures should be taken according to the appropriate level designated for COVID-19 infection prevention and control; (III) patients should take measures to protect themselves when they want to see a doctor, including accessing outpatient services online and other relevant channels of consultation. | 2020-06-05 |
| 32489929 | Chest computed tomography (CT) is frequently used in diagnosing coronavirus disease 2019 (COVID-19) for detecting abnormal changes in the lungs and monitoring disease progression during the treatment process. | 2020-06-05 |
| 32490506 | Acute ST-segment elevation myocardial infarction (STEMI) is a disease with high morbidity and mortality rates, and primary percutaneous coronary intervention is usually recommended for the treatment. | 2020-06-03 |
| 32490532 | A higher incidence of adverse events was observed when results were compared with studies involving patients on long-term hydroxychloroquine therapy. | 2020-06-26 |
| 32490720 | It is useful in the management of chronic disorders or for patients undergoing palliative treatment. […] The University Hospital of Palermo has applied this in cases of chronic illness caring for patients who cannot stop their treatment, such as Department of Onco-Haematology, Internal Medicine, Dermatology, etc. | 2020-06-26 |
| 32490726 | We believe it is useful and advisable to establish early immunomodulator therapy and the prophylaxis anticoagulant therapy should be rethought. | 2020-06-03 |
| 32490843 | South Korea took preemptive action against coronavirus disease (COVID-19) by implementing extensive testing, thorough epidemiological investigation, strict social distancing, and rapid treatment of patients according to disease severity. […] The Korean government entrusted large-scale hospitals with the operation of living and treatment support centers (LTSCs) for the management for clinically healthy COVID-19 patients. […] A multidisciplinary approach was integral to develop systems supporting patient care and management at the living and treatment support center as quickly as possible. | 2020-06-23 |
| 32490889 | Our results evidenced the potential use of coagulation modifiers in COVID-19 treatment due to the structural similarity of SARS-CoV-2 Mpro and human coagulation factors thrombin and Factor Xa. | 2020-06-09 |
| 32490913 | The authors conclude that telehealth offers capabilities for remote screening, care and treatment, and assists monitoring, surveillance, detection, prevention, and mitigation of the impacts on healthcare indirectly related to COVID-19. | 2020-06-09 |
| 32490931 | Considering that female sexual hormones may modulate the inflammatory response and also exhibit direct effects on the cells of the immune system, herein, we intend to discuss the sex differences and the role of estradiol in modulating the lung and systemic inflammatory response, focusing on its possible application as a treatment modality for SARS-CoV-2 patients. […] Direct and indirect mechanisms underlying the effects of estradiol were investigated, and the results point to a possible protective effect of estradiol against COVID-19, indicating that it may be considered as an adjuvant therapeutic element for the treatment of patients affected by the novel coronavirus. | 2020-06-11 |
| 32491073 | Intensive research is promising for the treatment and prevention of COVID-19. | 2020-06-09 |
| 32491075 | However, COVID-19 has a much greater and faster contamination and, unlike influenza, there is no vaccine or treatment available yet. | 2020-06-09 |
| 32491104 | The patient was started on glucocorticoids and non-invasive ventilator treatment. […] After treatment, the patient’s symptoms improved, and the status was confirmed as NCP negative. […] Our results may provide clues for the treatment of NCP. | 2020-06-06 |
| 32491199 | Convalescent plasma (CP) therapy is a potentially effective treatment option. | 2020-06-19 |
| 32491214 | In 1991 and 2009 the Italian sentinel surveillance system was established, consisting in 25 public centers (12 clinical, 13 laboratories) on the national field for diagnosis, treatment and data transmission to the INIH4 . | 2020-06-19 |
| 32492084 | To evaluate the efficacy and adverse effects of convalescent plasma therapy for patients with COVID-19. […] Convalescent plasma in addition to standard treatment (n = 52) vs standard treatment alone (control) (n = 51), stratified by disease severity. […] Convalescent plasma treatment was associated with a negative conversion rate of viral PCR at 72 hours in 87.2% of the convalescent plasma group vs 37.5% of the control group (OR, 11.39 [95% CI, 3.91-33.18]; P < .001). […] Among patients with severe or life-threatening COVID-19, convalescent plasma therapy added to standard treatment, compared with standard treatment alone, did not result in a statistically significant improvement in time to clinical improvement within 28 days. | 2020-06-13 |
| 32492188 | His clinical course of the COVID-19 pneumonia improved smoothly in 9 days; however, his immune status from HIV infection was not well-controlled due to a lack of antiretroviral therapy (ART). […] Antiretroviral therapy was given a month after the twice non-detections of SARS-CoV-2 to avoid immune reconstitution syndrome (IRIS). | 2020-06-19 |
| 32492203 | The challenge for today is building the assessment of genomic susceptibility to COVID-19 in lung cancer, requiring detailed experimental laboratory studies, in addition to in silico analyses, as a way of assessing the mechanism of novel virus invasion that can be used in the development of effective SARS-CoV-2 therapy. | 2020-06-19 |
| 32492205 | The patients were divided into early antiviral treatment group and late antiviral treatment group. […] Our data showed that the median time from illness onset to initiation of antiviral treatment was 6 days in all patients. […] The group with early antiviral treatment demonstrated 7 days shorter in the virus clearance time when compared to the group with late antiviral treatment. […] After virus clearance, the group with early antiviral treatment showed milder illness than the group with late antiviral treatment. […] Early antiviral treatment could effectively shorten the virus clearance time, and prevent the rapid progression of COVID-19. […] Therefore, the COVID-19 patients should receive combined therapies with antiviral treatment at early stage. | 2020-06-19 |
| 32492209 | In terms of in-hospital treatment, use differed not significantly between two groups. | 2020-06-19 |
| 32492211 | Additionally, demographic, clinical, treatment, laboratory and outcome data were also collected from electronic medical records. […] Moreover, the median time from onset to antiviral treatment initiation was 5.0 days (IQR 3.0-7.0). […] Delayed antiviral treatment (HR 0.976 [95% CI, 0.962-0.990]) and lopinavir/ritonavir + IFN-α combination therapy as the initial antiviral treatment (HR 1.649 [95% CI, 1.162-2.339]) were independent factors associated with prolonged SARS-CoV-2 RNA shedding. […] Early initiation of lopinavir/ritonavir + IFN-α combination therapy may help shorten the duration of SARS-CoV-2 shedding. | 2020-06-19 |
| 32492292 | Moreover, the two hits to the RAS may be the primary reason for increased mortality in patients with COVID-19 who have comorbidities and may serve as a therapeutic target for COVID-19 treatment. | 2020-06-25 |
| 32492354 | The Outcomes Related to COVID-19 treated with Hydroxychloroquine among In-patients with symptomatic Disease (ORCHID) trial is a multicenter, blinded, randomized trial of hydroxychloroquine versus placebo for the treatment of adults hospitalized with COVID-19. […] We discuss five novel challenges to the design and conduct of a large, multi-center, randomized trial during a pandemic, including: 1) widespread, off-label use of the study drug before the availability of safety and efficacy data; 2) the need to adapt traditional procedures for documentation of informed consent during an infectious pandemic; 3) developing a flexible and robust Bayesian analysis incorporating significant uncertainty about the disease, outcomes, and treatment; 4) obtaining indistinguishable drug and placebo without delaying enrollment; and 5) rapidly obtaining administrative and regulatory approvals. […] The ORCHID trial will provide high-quality, clinically relevant data on the safety and efficacy of hydroxychloroquine for the treatment of COVID-19 among hospitalized adults. | 2020-06-03 |
| 32492406 | Early detection and effective treatment of severe COVID-19 patients remain major challenges. | 2020-06-05 |
| 32492559 | Furthermore, weight loss interventions have been shown to improve psoriasis, as well as hidradenitis suppurativa, and increase responsiveness to treatment of this conditions. […] We suppose that due to aggressive isolation or restriction measures, in the next future dermatologist will face with a common worsening of chronic skin inflammatory conditions due to reduced physical activities, increased intake of calories with the derived increase body weight and always more frequent treatment discontinuation. | 2020-06-16 |
| 32492560 | Exploring compounds that could offer a breakthrough in treatment is the need of the hour. […] The paper proposes evidence for the potential use of diethylcarbamazine (DEC) in the treatment of COVID-19. | 2020-06-25 |
| 32492743 | Virus excretion in asymptomatic people and in the pre-symptomatic phase of an infection is relevant for transmission- An effective antiviral therapy has not yet been established. […] Steroids for anti-inflammatory therapy are not recommended- It is very important to prepare all actors in the health care system for a longer-term burden of inpatients and complications and to create the necessary capacities. | 2020-06-09 |
| 32492991 | The diagnosis of SARS-CoV-2 infection is crucial for medical and public health reasons, to allow the best treatment of cases and the best control of the pandemic. | 2020-06-04 |
| 32493147 | In this case, the importance of detection of the coronavirus and treatment of the coinfection is explored. | 2020-06-12 |
| 32493409 | Lacking an effective treatment, countries have implemented non-pharmaceutical interventions including social distancing measures and have encouraged maintaining adequate and frequent hand hygiene to slow down the disease transmission. | 2020-06-08 |
| 32493443 | To examine, if a shift in indications for radiotherapy is to be expected in the context of the COVID-19 pandemic, the database Pubmed was searched for multidisciplinary or surgical expert recommendations on the role of radiotherapy in modified treatment concepts. […] Increased use of radiotherapy or chemoradiation instead of surgical treatment was recommended for defined patient groups with head-and-neck cancer, lung cancer, cervix cancer, esophageal cancer and prostate cancer. […] Emerging recommendations on multidisciplinary cancer treatment concepts during the COVID-19 pandemic indicate a shift in radiotherapy indications and a potentially increased demand for radiotherapy. | 2020-06-15 |
| 32493447 | Comparison of the effect of hydroxychloroquine with placebo to prevent infection from the COVID -19 virus among healthcare professionals TRIAL DESIGN: Single centre, 2-arm, double-blind randomised (ratio 1:1) placebo-controlled trial PARTICIPANTS: Treatment staff who are in contact with patients and have at least 3 shifts a week in Arash hospital affiliated with Tehran University of Medical Sciences, in Iran and who consent to participate in the study. […] Allocation to the two treatment groups will be conducted by this researcher using paper labels (random 10-digit codes) in a 1:1 ratio t The labels will be attached to the drug packages in order of randomization. […] Participants and caregivers are blinded to group assignment and the data will be analyzed by an independent statistical expert who is unaware of the treatment allocation. | 2020-06-10 |
| 32493459 | Objective: To undertake a pilot, feasibility RCT of umbilical cord blood derived cell therapy for treatment of adult patients infected with SARS-CoV-2 virus related moderate-to-severe pneumonia to prevent progression to severe ARDS. […] Expanded cord blood derived cell therapy will be feasible, well tolerated and show potential efficacy in the treatment of acute COVID-19 related moderate to severe pneumonia in adult patients because of their powerful anti-inflammatory and immunomodulatory properties. | 2020-06-10 |
| 32493460 | For each list experiment, participants will be randomized to a control or treatment group. […] The control group will receive a list of five items and the treatment group will receive the same five items plus one item about COVID-19 hygiene. […] After completing the list experiment and questionnaire survey, participants in Arms 2 and 3 will receive the CoVideo to ensure post-trial access to treatment. […] Within each trial arm, Gorilla will randomly allocate participants at a 1:1 ratio to the control or treatment group. | 2020-06-10 |
| 32493468 | The investigator will enroll the patients and only then open envelopes to assign patients to the different treatment groups. | 2020-06-10 |
| 32493473 | The study will be conducted in Intensive Care Units in hospitals across the United Kingdom. […] Patients will be excluded for the following reasons: more than 72 hours from the onset of ARDS; age < 16 years; patient known to be pregnant; major trauma in previous 5 days; presence of any active malignancy (other than non-melanoma skin cancer); WHO Class III or IV pulmonary hypertension; venous thromboembolism currently receiving anti-coagulation or within the past 3 months; patient receiving extracorporeal life support; severe chronic liver disease (Child-Pugh > 12); Do Not Attempt Resuscitation order in place; treatment withdrawal imminent within 24 hours; prisoners; declined consent; non-English speaking patients or those who do not adequately understand verbal or written information unless an interpreter is available; previously enrolled in the REALIST trial. […] The cellular product (REALIST ORBCEL-C) was developed and patented by Orbsen Therapeutics. […] The cell therapy facility and clinical trials pharmacist will be unblinded to facilitate intervention and placebo preparation. […] The unblinded individuals will keep the treatment information confidential. | 2020-06-10 |
| 32493475 | Primary objective: to evaluate the efficacy of melatonin as a prophylactic treatment on prevention of symptomatic SARS-CoV-2 infection among healthcare workers at high risk of SARS-CoV-2 exposure. […] Secondary objectives: To evaluate the efficacy of melatonin as a prophylactic treatment on prevention of asymptomatic SARS-CoV-2 infection.To evaluate the efficacy of melatonin to prevent the development of severe COVID-19 in the participants enrolled in this study who develop SARS-CoV-2 infection along the trial.To evaluate the duration of COVID-19 symptoms in participants receiving melatonin before the infection.To evaluate seroconversion timing post-symptom onset. […] Inclusion Criteria: Male or female participants ≥ 18 and ≤ 80 years of age.Healthcare workers from the public and private Spanish hospital network at risk of SARS-CoV 2 infection.Not having a previous COVID19 diagnosis.Understanding the purpose of the trial and not having taken any pre-exposure prophylaxis (PrEP) including HIV PrEP from March 1st 2020 until study enrolment.Having a negative SARS-CoV 2 reverse-transcription PCR (RT-PCR) result or a negative serologic rapid test (IgM/IgG) result before randomization.Premenopausal women must have a negative urinary pregnancy test in the 7 days before starting the trial treatment.Premenopausal women and males with premenopausal couples must commit to using a high efficiency anticonceptive method. […] Weight less than 40 Kg.Participant with any immunosuppressive condition or hematological disease.Treatment with drugs that may prolong QT in the last month before randomization for more than 7 days including: azithromycin, chlorpromazine, cisapride, clarithromycin, domperidone, droperidol, erythromycin, halofantrine, haloperidol, lumefantrine, mefloquine, methadone, pentamidine, procainamide, quinidine, quinine, sotalol, sparfloxacin, thioridazine, amiodarone.Hereditary intolerance to galactose, Lapp lactase deficiency or glucose or galactose malabsorption.Treatment with fluvoxamine.Treatment with benzodiazepines or benzodiazepine analogues such as zolpidem, zopiclone or zaleplon.Pregnancy.Breastfeeding.History of potentially immune derived diseases such as: lupus, Crohn’s disease, ulcerative colitis, vasculitis or rheumatoid arthritis.Insulin-dependent diabetes mellitus.Known history of hypersensitivity to the study drug or any of its components.Patients that should not be included in the study at the judgment of the research team. […] Primary outcome will be measured until the end of treatment for each participant (until the date of the last dose taken by each patient). | 2020-06-10 |
| 32493478 | Primary Objective • To test the efficacy of Hydroxychloroquine (HCQ) (400 mg orally daily for 3 days then 200 mg orally daily for an additional 11 days, to complete 14 days) to prevent incident SARS-CoV-2 infection, compared to ascorbic acid among contacts of persons with SARS-CoV-2 infection Secondary objectives • To determine the safety and tolerability of HCQ as SARS-CoV-2 Post-exposure Prophylaxis (PEP) in adults • To test the efficacy of HCQ (400 mg orally daily for 3 days then 200 mg orally daily for an additional 11 days, to complete 14 days) to prevent incident SARS-CoV-2 infection 2 weeks after completing therapy, compared to ascorbic acid among contacts of persons with SARS-CoV-2 infection • To test the efficacy of HCQ to shorten the duration of SARS-CoV-2 shedding among those with SARS-CoV-2 infection in the HCQ PEP group • To test the efficacy of HCQ to prevent incident COVID-19 TRIAL DESIGN: This is a randomized, multi-center, placebo-equivalent (ascorbic acid) controlled, blinded study of HCQ PEP for the prevention of SARS-CoV-2 infection in adults exposed to the virus. […] Not planning to take HCQ in addition to the study medication Exclusion criteria Participants are excluded from the study if any of the following criteria apply: 1. […] Concomitant use of other anti-malarial treatment or chemoprophylaxis, including chloroquine, mefloquine, artemether, or lumefantrine.6. | 2020-06-10 |
| 32493494 |
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2020-06-10 |
| 32493510 | This situation has urgently impelled many companies and public research institutes to concentrate their efforts on research for effective therapeutics. | 2020-06-16 |
| 32493514 | Objective of this study is to evaluate the efficacy and safety of a single dose treatment with Tocilizumab in patients with severe COVID-19. […] Furthermore, this treatment might result in fewer admissions to intensive care units. […] Next to these efficacy parameters, safety of a therapy with Tocilizumab in COVID-19 patients has to be monitored closely, since immunosuppression could lead to an increased rate of bacterial infections, which could negatively influence the patient’s outcome. […] Immunosuppressive therapy (e.g. mycophenolate, azathioprine, methotrexate, biologicals, prednisolone >10mg/d; exceptions are: prednisolone ≤ 10mg/d, sulfasalazine or hydroxychloroquine)9. […] Intervention arm: Application of 8mg/kg body weight (BW) Tocilizumab i.v. once immediately after randomisation (12 mg/kg for patients with <30kg BW; total dose should not exceed 800 mg) AND conventional treatment. […] Control arm: Placebo (NaCl) i.v. once immediately after randomisation AND conventional treatment. […] The randomisation code will be generated by the CTU (Clinical Trials Unit, ZKS Freiburg) using the following procedure to ensure that treatment assignment is unbiased and concealed from patients and investigator staff. | 2020-06-10 |
| 32493604 | As a result of the significant circumstances, delaying diagnosis and treatment of AA during SARS-Cov-2 pandemic, inappropriate management of this common surgical disorder has been noticed. | 2020-06-06 |
| 32493626 | So far, there has been not much progress in terms of drug development for fighting against this deadliest virus, also no existing drugs has been reported completely effective for COVID-19 treatment owing to lack of effective therapeutic targets and a broad understanding of the viral behavior in target cell. […] In current write up we hypothesize that S1 subunit and host proteases as potential therapeutic avenues for the treatment of COVID-19. | 2020-06-06 |
| 32493734 | Much remains unknown about the risk factors, pathogenesis, prognosis, and specific therapy for this emerging manifestation of COVID-19 known as Multisystem Inflammatory Syndrome in Children (MIS-C). […] MIS-C is rare and early recognition is crucial though no standardized treatment guideline have been established. | 2020-06-04 |
| 32493737 | If we are to be prepared to face the many challenges of this pandemic, we must prioritize the ethical demands to our treatment and management concerns. | 2020-06-04 |
| 32493739 | The primary outcomes were clinical and biological data, imaging and echocardiographic findings, treatment, and outcomes. | 2020-06-16 |
| 32493740 | An exception was treatment with lopinavir/ritonavir, for which we found low-quality evidence for a decrease in length of stay in the intensive care unit (risk difference 5 d shorter, 95% confidence interval [CI] 0 to 9 d) and hospital stay (risk difference 1 d shorter, 95% CI 0 to 2 d). […] For safety outcomes, evidence was of low or very low quality, with the exception of treatment with lopinavir/ritonavir for which moderate-quality evidence suggested likely increases in diarrhea, nausea and vomiting. […] To date, persuasive evidence of important benefit in COVID-19 does not exist for any antiviral treatments, although for each treatment evidence has not excluded important benefit. | 2020-06-04 |
| 32493814 | We discuss available pharmaceutical agents that target a critical component of inflammasome activation, signaling leading to cellular pyroptosis, and the downstream cytokines as a promising target for the treatment of severe coronavirus disease 2019-associated diseases. | 2020-06-04 |
| 32493868 | A comprehensive categorization and score scale assessment for dental emergencies allows a better identification of patient’s treatment needs and avoids unnecessary contact between dental health care providers and patients during the SARS-CoV-2 pandemic. | 2020-06-26 |
| 32494546 | To date, there is no approved targeted treatment, and many investigational therapeutic agents and vaccine candidates are being considered for the treatment of COVID-19. […] Currently, there are no effective specific antivirals or drug combinations available for the treatment of COVID-19. | 2020-06-06 |
| 32494567 | In this review the SARS-CoV-2 morphology, pathogenic mechanism, similarities and differences between SARS-CoV and Middle East Respiratory Syndrome and severe acute respiratory syndrome, transmission mode, diagnosis, treatment, and preventive measures were investigated. […] To date, there is no vaccine or no specific treatment for COVID-19. | 2020-06-06 |
| 32494800 | Acute ST-segment elevation myocardial infarction (STEMI) is a disease with high morbidity and mortality rates, and primary percutaneous coronary intervention is usually recommended for the treatment. | 2020-06-04 |
| 32494856 | The patients continued teriflunomide therapy and had self-limiting infection, without relapse of their MS. | 2020-06-06 |
| 32494896 | However, arrhythmia manifestations and treatment strategies used in these patients have not been well-described. […] We sought to better understand the cardiac arrhythmic manifestations and treatment strategies in hospitalized COVID-19 patients through a worldwide cross-sectional survey. […] There were 140 of 631 (22.2%) respondents who reported using anticoagulation therapy in all COVID-19-positive patients who did not otherwise have an indication. […] Sixty of 489 respondents (12.3%) reported having to discontinue therapy with HCQ + AZM due to significant QTc prolongation and 20 (4.1%) reported cases of Torsade de Pointes in patients on HCQ/chloroquine and AZM. […] Large prospective studies to better define arrhythmic manifestations as well as the safety of treatment strategies in COVID-19 patients are warranted. | 2020-06-06 |
| 32494921 | From a public health perspective, strategies have to be developed to assure patients are seeking and getting medical care and treatment in time during SARS-CoV-2 pandemic. | 2020-06-06 |
| 32494931 | To date, there is no licensed treatment or approved vaccine to combat the coronavirus disease of 2019 (COVID-19), and the number of new cases and mortality multiplies every day. […] Therefore, it is essential to develop an effective treatment strategy to control the virus spread and prevent the disease. […] Although it seems that antiviral drugs are effective in improving clinical manifestation, there is no definite treatment protocol. […] There is no doubt that more studies are required to clarify immunopathogenesis and immune response; however, new therapeutic approaches including mesenchymal stromal cell and immune cell therapy showed inspiring results. | 2020-06-23 |
| 32495030 | In oncology, malnutrition was and certainly still is a frequent problem associated with an increase in treatment-related toxicity, a reduced response to cancer treatment, an impaired quality of life, and a worse overall prognosis. | 2020-06-06 |
| 32495226 | In the absence of a vaccine and specifically designed antivirals, the medical community has proposed the use of various previously available medications in order to reduce the number of patients requiring prolonged hospitalizations, oxygen therapy, and mechanical ventilation and to decrease mortality from coronavirus disease 2019 (COVID-19). […] The objective of this article is to review and discuss the possible role of these drugs in the therapy of COVID-19. | 2020-06-06 |
| 32495280 | The priority was made for treatment of COVID-19 patients and emergency cases. | 2020-06-06 |
| 32495299 | Hence, it has been speculated that the treatment with these agents might influence the course of the infection, and both harmful and beneficial effects have been supposed. | 2020-06-06 |
| 32495323 | However, intensive care unit (ICU) survivors may experience complications and problems related to their disease and treatment such as critical illness polyneuropathy, critical illness myopathy, and post intensive care syndrome (PICS; Alhazzani et al., 2020). | 2020-06-08 |
| 32495334 | International medical nurses directly affect the quality and effectiveness of international medical treatment. | 2020-06-08 |
| 32495339 | In this paper, we strongly advocate for universal palliative care access during the COVID-19 pandemic. […] The delivery of universal palliative care services has been called for by leading global health organizations and experts. […] COVID-19 diagnoses and fatalities continue to rise, underscoring the importance of palliative care, particularly in the context of scant resources. […] To inform the writing of this paper, we undertook a review of the COVID-19 and palliative care literature and drew on our experiences. […] It is very clear that investment in nurses is needed to ensure appropriate palliative care services now and into the future. […] Multi-level practices and policies to foster the delivery of safe, high-quality palliative care for all are urgently needed. | 2020-06-24 |
| 32495400 | All patients had pneumonia and nasopharyngeal swab PCR positive for SARS CoV-2 and had received treatment for Covid-19 per protocol established. | 2020-06-19 |
| 32495574 | In this paper, we analyzed medical records of 40 patients with coronavirus disease 2019(COVID-19), in order to explore the clinical efficacy of Matrine and Sodium Chloride Injection in the treatment of COVID-19. […] The investigation was based on the results of a previous animal test, which was aimed to investigate and confirme the clinical efficacy of Matrine and Sodium Chloride Injection in the treatment of COVID-19. […] In these cases, patients were treated with other integrated Chinese and Western medicines regimens in the recommended Matrine and Sodium Chloride Injection diagnosis and treatment regimen. […] The clinical manifestations, laboratory data, nucleic acid clearance time, and imaging data were compared and analyzed before and after treatment. […] We believed that Matrine and Sodium Chloride Injection have a good clinical effect in the treatment of COVID-19, and suggested increasing the clinical application and further conducting large-sample-size cli-nical verification. | 2020-06-08 |
| 32495575 | The statistics was based on the data of the cases treated with Ganlu Xiaodu Decoction, including demographic statistics, clinical cha-racteristics before medication, outcome of after medication and efficacy of drug combination. […] There is a certain regularity and effectiveness in the treatment of COVID-19 infection patients with the combination of Ganlu Xiaodu Decoction and other drugs, but the rationality and safety still need to be further verified. | 2020-06-08 |
| 32495577 | The study aimed to investigate the multi-constituent, multi-target mechanism of Xuanfei Baidu Tang(XFBD) in the treatment of coronavirus disease 2019(COVID-19), through exploring the main ingredients and effective targets of XFBD, as well as analyzing the correlation between XFBD targets and COVID-19. | 2020-06-08 |
| 32495578 | TCMATCOV adopted quantitative evaluation algorithm of disease network disturbance after multi-target drug attack to predict potential drug effects. | 2020-06-08 |
| 32495579 | These become the common characteristics of medical prevention and treatment programs for ethnomedicine to formulate therapeutic programs under the guidance of traditional medicine theories, recommend prescriptions and prevention and treatment methods with characteristics of ethnomedicine, and focus on the conve-nience and standardization. | 2020-06-08 |
| 32495580 | The curative effects of integrated traditional Chinese medicine and Western medicine in the treatment of COVID-19 have been widely recognized and confirmed. […] Based on the guideline from the Diagnosis and Treatment Plans for COVID-19(trial seventh edition), taking the recommended drugs as examples, by Western medicine, traditional Chinese medicine, Chinese herbal injection and integrated traditional Chinese and Western medicine, the study analyzed the basic characteristics of recommended drugs for cardiac injury by means of literature review and bioinformatics methods, and summarized cardiac adverse reactions, toxicity mechanisms, combined pharmacotherapy, special population and drug monitoring, focusing on the clinical manifestations, toxic components, targets and regulatory mechanisms of drug-induced cardiac injury. […] The findings suggested being vigilant to drug-induced cardiac injury during the treatment of COVID-19, playing the advantages of clinical pharmacists and clinical Chinese pharmacists, improving the knowledge reserve of pharmacovigilance, strengthening the prescription review, medication notification and medication monitoring, promoting rational drug use and paying attention to special populations and high-risk groups. | 2020-06-08 |
| 32495581 | Main points of ethical review of traditional Chinese medicine were summarized in the aspects of overall concept, syndrome differentiation and treatment, prevention before disease onset, cultural value, and clinical basis. | 2020-06-08 |
| 32495582 | In the determination of intervention measures, not only the effectiveness evaluation, but also accessibility, treatment cost, inventory and production capacity and other relevant sociological issues shall be considered, especially in low and middle-income countries and regions. […] For the evidence-based evaluation of TCM intervention in new public health emergencies, the basic principles and general methods of clinical epidemiology and evidence-based medicine shall be followed to obtain high-quality evidence; besides, we shall also fully realize that clinical scientific study is carried out with the epidemic treatment as the primary task. […] The scientific study conclusions aim to give feedbacks to clinical diagnosis and treatment regimens. […] It is suggested that scientific experimental design, rigorous collection and scientific data analysis shall be conducted to reflect the therapeutic value of traditional Chinese medicine, so that the study results could be adopted and shared, and become the scientific evidence for China and even the global to republish the diagnosis and treatment regimens. | 2020-06-08 |
| 32495826 | We conducted a national survey among IBD gastroenterologist members of the Spanish Working Group on Crohn’s Disease and Colitis regarding changes of practice, IBD treatments, and diagnosis and treatment of COVID-19. […] We also found that 96.1% of IBD units advised their patients to maintain treatment if they were asymptomatic for COVID-19. […] In addition, 7.5% of IBD units made a COVID-19 diagnosis through polymerase chain reaction and/or chest x-ray.Modifications in IBD treatment and treatment recommended for COVID-19 are also discussed. | 2020-06-26 |
| 32495913 | A nasal swab for COVID-19 was performed, which resulted positive, and so therapy with doxycycline, hydroxychloroquine and antiviral agents was started. | 2020-06-10 |
| 32495915 | During the COVID-19 pandemic, it is necessary to establish standardized out-patient protocols to provide safe and effective treatment for osteoporosis patients and medical staff. […] In an osteoporosis clinic, we advocate the following suggestions to prevent and control osteoporosis during the pandemic period: (1) specialized diagnosis and treatment techniques for osteoporosis patients in the outpatient care, including enhancing the prevention for outpatient medical staff, strengthening awareness of COVID-19 prevention, strictly screening outpatients with COVID-19 infection, and insistent administration of anti-osteoporosis drugs during outbreaks; (2) home prevention for osteoporosis patients including keeping windows open, exposing them to sunlight, supplementing them with enough protein, exercising regularly, and administrating calcium supplements; and (3) simplifying the follow-up and evaluation of osteoporosis using online platforms. | 2020-06-10 |
| 32495917 | The aim was to investigate the viral kinetics and factors associated with viral clearance during lopinavir/ritonavir-based combination treatment in non-severe patients. […] The viral shedding exhibited different patterns during treatment. | 2020-06-10 |
| 32495921 | Currently, there is no specific cure or preventive therapeutics available. | 2020-06-10 |
| 32495940 | Understanding mechanisms of the novel SARS-CoV2 infection and progression, can provide potential novel targets for prevention and/or treatment. | 2020-06-19 |
| 32495979 | Scientists have started trials on potential preventive and treatment options. […] Currently, there is no specific approved treatment for SARS-CoV-2, and various clinical trials are underway to explore better treatments. […] Here we summarize the fight against this novel coronavirus with particular focus on the different treatment options and clinical trials exploring treatment as well as work done toward development of vaccines. | 2020-06-19 |
| 32496012 | Therefore, intensive monitoring and antidiabetic therapy should be considered in diabetic patients with SARS-CoV-2 infection. | 2020-06-22 |
| 32496122 | Granulo-monocytoapheresis is a treatment used in ulcerative colitis outbreaks, whose mechanism of action is to selectively retain activated granulocytes and monocytes, in order to reduce the inflammatory process. | 2020-06-19 |
| 32496123 | With the except of the clinical practice, currently there is no recommendation based on scientific evidence about the use of apheresis in the treatment of ulcerative colitis (UC), and even less in Crohn’s disease (CD). | 2020-06-18 |
| 32496207 | A number of studies about disease diagnosis and treatment have been carried out, and many clinically proven effective results have been achieved. […] This issue becomes even more serious if the knowledge for diagnosis and treatment is updated rapidly as is the case for COVID-19. […] This study aims to develop a shared data model based on the openEHR modeling approach to improve the interoperability among systems for the diagnosis and treatment of COVID-19. […] The latest Guideline of COVID-19 Diagnosis and Treatment in China was selected as the knowledge source for modeling. […] First, the guideline was analyzed and the data items used for diagnosis and treatment, and management were extracted. | 2020-06-17 |
| 32496210 | Since the outbreak of coronavirus disease (COVID-19) that was discovered in 2019 in Wuhan, China, no standard therapy guideline has been set despite the severity of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and its high infectivity. […] A dual-combination of ribavirin and interferon-α has been the widely used regimen for the treatment of this disease in China. […] However, due to the varying results of treatment with these drugs, a novel antiviral combination therapy is urgently needed. | 2020-06-04 |
| 32496239 | Several clinical trials worldwide are evaluating several drugs approved for other indications, as well as multiple investigational agents for the treatment and prevention of COVID-19. […] Here, we give a brief overview of pharmacological agents and other therapies which are under investigation as treatment options or adjunctive agents for patients infected with COVID-19 and for chemoprophylaxis for the prevention of COVID-19 infection. | 2020-06-17 |
| 32496241 | Hydroxychloroquine (HCQ), an antimalarial has been proposed as possible treatment for coronavirus disease-2019 (COVID-19). […] In this review, we go over the available evidence for and against HCQ’s use as prophylaxis or treatment for COVID-19, especially in the Indian context. | 2020-06-17 |
| 32496246 | Increased testing, intensive case-based surveillance and containment efforts, modulated movement restrictions while protecting the vulnerable population, and continuous monitoring of transmission dynamics should be a way forward in the absence of effective treatment, vaccine, and undetermined postinfection immunity. | 2020-06-17 |
| 32496248 | In the absence of any approved treatment or vaccine against novel Severe Acute Respiratory Syndrome Coronavirus -2 (SARS-CoV-2) infection, Non-Pharmaceutical Interventions (NPIs) are the cornerstone to prevent the disease, especially in a populous country like India. | 2020-06-17 |
| 32496364 | Therefore, one can speculate that discontinuing ACE inhibitor or ARB therapy may lead to decreased ACE2 expression, thereby attenuating the infectivity of SARS-CoV-2, and mitigating the disease progression of COVID-19. […] However, several studies have also shown that ACE2 exhibits reno- and cardioprotection and preserves lung function in acute respiratory distress syndrome, which would favor ACE inhibitor or ARB therapy. | 2020-06-15 |
| 32496422 | The effects of corticosteroid treatment on non-severe COVID-19 pneumonia patients are unknown. | 2020-06-04 |
| 32496858 | Community nurses have supported dentists through specific training and competencies so that the latter are equipped with skills to support roles including wound care, catheter care and medication administration. | 2020-06-16 |
| 32496872 | Although current understanding of COVID-19 treatment mainly derives from small uncontrolled trials that are affected by a number of biases, strong background noise and a litany of confounding factors, emerging awareness suggests that drugs currently used to treat COVID-19 (antivirals, antimalarials, immunomodulators, anticoagulants, antibodies) should be evaluated in relation to the pathophysiology of disease progression. | 2020-06-11 |
| 32496926 | Antiviral therapy is the most important treatment for COVID-19. […] Among the drugs under investigation, anti-malarials, chloroquine (CQ) and hydroxychloroquine (HCQ), are being repurposed as treatment for COVID-19. | 2020-06-22 |
| 32496938 | While the COVID-19 epidemic occurred since December 2019, as of end April 2020, no treatment has been validated or invalidated by accurate clinical trials. […] Use of hydroxychloroquine has been popularised on mass media and put forward as a valid treatment option without strong evidence of efficacy. […] Belgian national treatment guidelines recommend the use of HCQ in mild to severe COVID-19 disease. […] As opinions, politics, media and beliefs are governing COVID-19 therapy, performance of randomised controlled blinded clinical trials became difficult. | 2020-06-12 |
| 32497318 | Recent COVID-19 pandemic guidelines recommend genomic assessment of core biopsies to help guide treatment decisions in estrogen receptor (ER)-positive early-stage breast cancer. | 2020-06-04 |
| 32497344 | Most probable diagnosis was COVID-19 induced immune thrombocytopenia (ITP) and high dose intravenous immunoglobulin (IVIg) treatment generated a good response. | 2020-06-19 |
| 32497535 | Several specific anti-inflammatory/immunosuppressive agents are being evaluated by ongoing clinical trials; however, there is currently insufficient evidence for their efficacy and safety in COVID-19 treatment. […] Due to their mechanism of action targeting an early stage of the inflammatory response and ameliorating lung inflammation, we believe that selective PDE4 inhibitors may represent a promising treatment option for the early phase of COVID-19 pneumonia before the cytokine storm and severe multiorgan dysfunction take place. | 2020-06-27 |
| 32497632 | The recent advancements and future perspective of ongoing research for therapy and detection of SARS-CoV-2 are provided. […] The review, in brief, summarizes epidemiology, therapy and the current scenario for combating SARS-CoV-2. | 2020-06-28 |
| 32497662 | Sudden dramatic changes in the environment, medical practice, and medication use have altered the asthma management landscape with potential impacts on asthma outcomes. | 2020-06-12 |
| 32497745 | Subjects with complicated DFUs received outpatient evaluation (within 48-72 h) and were admitted to hospital if required (revascularization, surgical intervention, intravenous antibiotic therapy); after the first outpatient visit or hospitalization, patients were followed according to the number of comorbidities (in the case of 3 or more comorbidities patients were followed up by telemedicine). | 2020-06-28 |
| 32497746 | Utilizing case-specific treatment planning for vascular patients with COVID-19, favoring minimally invasive methods; 4. | 2020-06-06 |
| 32497747 | The global SARS-CoV-2/COVID-19 pandemic has required a reduction in non-emergency treatment for a variety of disorders. […] This report summarizes conclusions of an international multidisciplinary consensus group assembled to address evaluation and treatment of patients with thoracic outlet syndrome (TOS), a group of conditions characterized by extrinsic compression of the neurovascular structures serving the upper extremity. […] The following recommendations were developed in relation to the 3 defined types of TOS (neurogenic, venous, and arterial) and 3 phases of pandemic response (preparatory, urgent with limited resources, and emergency with complete diversion of resources): (1) In-person evaluation and treatment for neurogenic TOS (interventional or surgical) is generally postponed during all pandemic phases, with telephone/telemedicine visits and at-home physical therapy exercises recommended when feasible. […] (2) Venous TOS presenting with acute upper extremity deep vein thrombosis (Paget-Schroetter syndrome) is managed primarily with anticoagulation, with percutaneous interventions for venous TOS (thrombolysis) considered in early phases (I and II) and surgical treatment delayed until pandemic conditions resolve. […] Catheter-based interventions may also be considered for selected patients with central subclavian vein obstruction and threatened hemodialysis access in all pandemic phases, with definitive surgical treatment postponed. […] (3) Evaluation and surgical treatment for arterial TOS should be reserved for limb-threatening situations, such as acute upper extremity ischemia or acute digital embolization, in all phases of pandemic response. […] In late pandemic phases surgery should be restricted to thrombolysis or brachial artery thromboembolectomy, with more definitive treatment delayed until pandemic conditions resolve. | 2020-06-06 |
| 32497751 | Delayed diagnosis, lack of cancer awareness, low adherence to treatment, and unequal or limited access to treatment are among the challenging factors of cancer management in developing countries. | 2020-06-26 |
| 32497796 | The combination of rt-PA with targeted anti-inflammatory treatment could be a new therapeutic option for patients with COVID-19, ARDS, hyperinflammation, and increased blood viscosity. | 2020-06-28 |
| 32498076 | It remains unknown whether the treatment of hypertension influences the mortality of patients diagnosed with coronavirus disease 2019 (COVID-19). […] The hospital was dedicated solely to the treatment of COVID-19 in Wuhan, China. […] Patients with a history of hypertension but without antihypertensive treatment (n = 140) were associated with a significantly higher risk of mortality compared with those with antihypertensive treatments (n = 730) (7.9% vs. […] While hypertension and the discontinuation of antihypertensive treatment are suspected to be related to increased risk of mortality, in this retrospective observational analysis, we did not detect any harm of RAAS inhibitors in patients infected with COVID-19. | 2020-06-22 |
| 32498085 | The pandemic of COVID-19 has presented new challenges to hospital personnel providing care for infected patients with diabetes who represent more than 20% of critically ill patients in intensive care units. | 2020-06-26 |
| 32498128 | The psychosocial effects of the pandemic, an increase in contact dermatitis and several other skin diseases because of stress, disinfectants and protective equipment use, especially in health care workers, the temporary limited access to dermatologic care, the dilemma whether or not to pause immunosuppressive therapy, and, finally, the occurrence of skin lesions in patients infected by COVID-19 all contribute to significant quality of life (QoL) impairment. | 2020-06-19 |
| 32498207 | This Dutch study confirms that there is a (highly) significant inverse correlation between pollen count and weekly changes in medical flu consults, and that there is a highly significant inverse correlation between hay fever incidence, as measured by prescribed medication revenues, and weekly flu consults. | 2020-06-09 |
| 32498262 | Four patients received mechanical ventilation and continuous renal replacement therapy at a median duration of 14.0 and 8.5 days, respectively. […] Despite the high-risk conditions associated with worse outcomes, patients on HD did not exhibit extremely poor overall COVID-19 outcomes perhaps due to early diagnosis, prompt hospitalization, and antiviral therapy. | 2020-06-05 |
| 32498493 | However, the case fatality in Wuhan has being kept the highest in China, indicating that clinical treatment for this virus-caused emerging infectious disease, whose pathogenesis remains to be elucidated, had a limited effect in controlling this epidemic. […] Recently, profit-seeking mechanism run in Chinese health service system disorganized the balance of clinical service and public health service patterns in China, promoting the vicious circle of “attaching importance to clinical treatment and despising disease prophylaxis” , damaging the infrastructure of public health capacity, thus contributing to the formation of the inevitability in various fortuities of public health emergency. […] Second, the vicious circle of profit-seeking-caused “attaching importance to clinical treatment and despising disease prophylaxis” should be immediately broken to optimize the national health service system in China by increasing the investment in public health service. | 2020-06-05 |
| 32498556 | The COVID-19 pandemic continues to significantly impact the treatment of people living with aortic stenosis, and access to transcatheter aortic valve implantation. […] We propose an alternative streamlined evaluation pathway to minimize patients’ pre-procedure exposure to the hospital environment while ensuring appropriate treatment decision and shared decision-making. | 2020-06-05 |
| 32498612 | Analyzing the available literature, there is very scarce evidence regarding the use of MIS and robotics for treatment of pediatric surgical and urological pathologies during this pandemic. | 2020-06-05 |
| 32498686 | The advancement in our understanding of the mechanisms underlying the host immune responses promises to facilitate the development of approaches for prevention or treatment of diseases. […] We also describe the diagnostic methods being used for COVID-19 identification and summarize the current status of various therapeutic strategies, including vaccination, being considered for treatment of the disease. | 2020-06-10 |
| 32498696 | Animal models that mimic the human disease are highly essential to develop therapeutics and vaccines against COVID-19. […] This literature review aims to present the importance of utilizing the human ACE2 transgenic mouse model to better understand the pathogenesis of COVID-19 and develop both therapeutics and vaccines. | 2020-06-15 |
| 32498762 | A comprehensive search using the PubMed database was carried out to summarize the latest published information about the epidemiology, definition, pathogenesis, clinical characteristics, treatment options, prognosis and prevention of coronavirus disease 2019. | 2020-06-05 |
| 32498938 | The possibility of coagulopathies in peri- and postmenopausal women taking estrogen therapies makes it necessary to consider antithrombotic strategies, such as the use of low molecular weight heparins (LMWH) at specific prophylactic or treatment doses for each individual case, depending on the risk factors that each woman presents. […] For such reasons, a panel of experts from various Spanish scientific societies has met to develop usage recommendations for managing menopausal women taking menopausal hormone therapy (MHT) or combined hormonal contraception (CHC) during the COVID-19 pandemic. | 2020-06-09 |
| 32499132 | These areas include: the types of data that would help clarify risks for PwDs and help assure their safety long term; the prevention, treatment and mitigation measures for PwDs that are needed through the duration of the outbreak; and the issues of equity in access to and quality of medical care for PwDs. | 2020-06-08 |
| 32499154 | The viruses remain a threat till date and are of serious concern since no vaccine or specified drug therapy has been approbated for treating human coronaviruses. | 2020-06-08 |
| 32499161 | Barriers to deprescribing before the pandemic include patient and system related factors, such as resistance to change, patient’s knowledge deficit about deprescribing, lack of alternatives for treatment of disease, uncoordinated delivery of health services, prescriber’s attitudes and/or experience, limited availability of guidelines for deprescribing, and lack of evidence on preventative therapy. […] Some of these barriers can be mitigated by using the following interventions:patient education, prioritization of non-pharmacological therapy, incorporation of electronic health record (EHR), continuous prescriber education, and development of research studies on deprescribing. | 2020-06-08 |
| 32499236 | Cardiac troponin levels are significantly higher in patients with more severe infections, patients admitted to intensive care units or in those who have died. | 2020-06-05 |
| 32499303 | Treatment options for non-hospitalised patients with coronavirus disease 2019 (COVID-19) to reduce morbidity, mortality and spread of the disease are an urgent global need. […] The over-the-counter histamine-2 receptor antagonist famotidine is a putative therapy for COVID-19. | 2020-06-24 |
| 32499448 | More older patients received immunoglobulin therapy and mechanical ventilation. | 2020-06-26 |
| 32499832 | To date, clinical evidence and guidelines based on reliable data and randomized clinical trials for the treatment of COVID-19 are lacking. […] Corticosteroids and tocilizumab seem to guarantee positive results in selected patients so far, although the timing of starting therapy and the most appropriate therapeutic schemes remain to be clarified. | 2020-06-07 |
| 32499983 | While there is no consensus on the treatment of the disease yet, understanding the virus and its transmission is a cardinal priority. […] We also elaborate on the current research and evidence on treatment options and vaccine development based on the literature. | 2020-06-07 |
| 32500134 | An online survey covering key areas for esophagogastric cancer services, including staging investigations and oncological and surgical therapy before and during (at two separate time-points-24th March 2020 and 18th April 2020) the COVID-19 pandemic were developed. | 2020-06-26 |
| 32500409 | In light of the current data, the aspects of COVID-19 resembling rheumatic diseases, the possible reasons for why children are affected less severely, the hypothetic role of available vaccines in preventing COVID-19, the unique position of patients with rheumatic diseases in this pandemic, and the use of anti-rheumatic drugs in COVID-19 treatment are discussed. | 2020-06-26 |
| 32500431 | Few patients had liver cirrhosis (12.5%) or received preoperative systemic therapy (16.6%). 36 (50%) high-risk surgical procedures were performed, including major hepatectomies, pancreaticoduodenectomies, total gastrectomies, multivisceral resections, and transplantations. | 2020-06-08 |
| 32500509 | An early diagnosis of COVID-19 is crucial for disease treatment and control of the disease spread. | 2020-06-25 |
| 32500510 | Hospital administrations had to provide a prompt response to a rapidly evolving emergency characterized by the necessity of giving access to an enormous number of infected patients, guaranteeing appropriate care to patients in need of other types of treatment, and simultaneously preserving the well-being of healthcare providers. | 2020-06-25 |
| 32500518 | The majority of endocrine disorders requiring surgical treatment in patients identifiable as first-priority class, or needing hospitalization within 30 days, are generally represented by malignant thyroid tumors, hyperthyroidism, hyperparathyroidism, and some adrenal disorders. | 2020-06-25 |
| 32500526 | A significant numberof the patients are on treatment with biologicals and clinicians face the challenge to provide optimal care during the pandemic. […] At present, non-infected patients on biologicals for the treatment of asthma, atopic dermatitis, chronic rhinosinusitis with nasal polyps or chronic spontaneous urticaria should continue their biologicals targeting type 2 inflammation via self-application. […] In case of an active SARS-CoV-2 infection, biological treatment needs to be stopped until clinical recovery and SARS-CoV-2 negativity is established and treatment with biologicals should be re-initiated. […] Maintenance of add-on therapy and a constant assessment of disease control, apart from acute management is demanded. | 2020-06-19 |
| 32500549 | We also review the recommended management of pregnant women with suspected or confirmed COVID-19 and the various pharmacological agents that are being investigated and may have a role in the treatment of this disease. | 2020-06-19 |
| 32500793 | Here we suggest including nimesulide in the list of drugs to be tested for the identification of co-adjuvants in the treatment of COVID-19. | 2020-06-05 |
| 32500942 | Accordingly, treatment and changes to immunosuppression were adapted to the severity of the disease. […] Besides depicting Covid-19 course and possible treatment scenarios in liver transplant patients, these cases are discussed in relation to the changes in our practice prompted by Covid-19 epidemic, with potential implications for other transplant programs. | 2020-06-19 |
| 32501022 | Prior to the Coronavirus disease 2019 (COVID-19) epidemic, stable patients with chronic conditions attended the facility or support groups to obtain their medication. […] During the COVID-19 epidemic, these patients would be put at risk if they had to travel and gather in groups to receive medication. […] The Metropolitan Health Services, therefore, decided to offer home delivery of medication. […] Medication was delivered as usual to primary care pharmacies, but then a variety of means were used to disseminate the parcels to local non-profit organisations, where they could be delivered by a city-wide network of community health workers (CHWs). | 2020-06-09 |
| 32501023 | The effective use of available resources in response to the epidemic should mainly focus on community mobilisation and PHC teams for the prevention, screening, testing and treatment of mild and moderate cases. | 2020-06-16 |
| 32501190 | Hypertension medication modulation, may alter ACE2 and angiotensin(1-7), particularly in variants that have been shown to influence renin-angiotensin-aldosterone system function, which could be clinically useful in patients with COVID-19. | 2020-06-05 |
| 32501218 | Since the physiological Cav-1 deficiency appears to prevent acute cell damage treatment algorithms could potentially be developed to block this pathway in the non-pregnant population affected by SARS-CoV-2. | 2020-06-26 |
| 32501293 | Our data also suggest that measurement of levels of CCL5, as well as IL-1Ra, IL-10 in blood individually and in combination might be useful prognostic bio-markers to guide treatment strategies. | 2020-06-05 |
| 32501367 | Currently no specific medicinal treatment exists against the new SARS-CoV2 and chloroquine is widely used, since it can decrease the length of hospital stay and improve the evolution of the associated COVID-19 pneumonia. […] The aim of this study is to provide a critical appraisal of the safety information regarding chloroquine treatment and to apply simulation techniques to unveil relationships between the observed serious adverse events and overdosing, as well as to propose optimized dosage regimens. […] Among others, treatment with chloroquine can lead to severe adverse effects like prolongation of the QT interval and cardiomyopathy. […] Co-administration of chloroquine with other drugs for the treatment of COVID-19 patients, like azithromycin, can further increase the risk of QT prolongation and cardiomyopathy. | 2020-06-08 |
| 32501377 | The health officials and government should adopt new strategies to control the pandemic from further spread until a proper treatment or vaccine is developed. | 2020-06-08 |
| 32501378 | The latest version of human coronavirus said to be COVID-19 came out as a sudden pandemic disease within human population and in the absence of vaccination and proper treatment till date, it daunting threats heavily to human lives, infecting more than 12, 11, 214 people and death more than 67, 666 people in 208 countries across the globe as on April 06, 2020, which is highly alarming. […] When no treatment or vaccine is available till date and to avoid COVID-19 to be transmitted in the community, social distancing is the only way to prevent the disease, which is well taken into account in our novel epidemic models as a special compartment, that is, home isolation. […] Our research reveals that home isolation and quarantine to hospitals are the two pivot force-control policies under the present situation when no treatment is available for this pandemic. | 2020-06-08 |
| 32501392 | We use the DPSIR (Drivers-Pressures-State change-Impact-Response) framework to explore three aspects of zoonotic diseases: (1) the significance of disease regulation ecosystem services and their degradation in the emergence of Covid-19 and other zoonotic diseases; and of the protection of natural resources as mitigating contributions to both (2) regulating human-to-human disease transfer; and (3) treatment of disease outbreaks. | 2020-06-09 |
| 32501423 | Analysis of its genome may provide clues toward the proper treatment of patients and the design of new drugs and vaccines. | 2020-06-16 |
| 32501429 | Hence, we propose the use of nanofiber filters as a wastewater pretreatment routine and upgradation of existing wastewater evaluation and treatment systems to serve as a beneficial surveillance tool. | 2020-06-08 |
| 32501454 | In areas of pandemic outbreak, the number of patients can exceed maximum capacity of intensive care units (ICUs), and, thus, these individuals often receive non-invasive ventilation outside of the ICU. […] We included consecutive patients (aged ≥18 years) with COVID-19, moderate-to-severe ARDS, and hyperinflammation (defined as serum C-reactive protein ≥100 mg/L, ferritin ≥900 ng/mL, or both) who were managed with non-invasive ventilation outside of the ICU and who received standard treatment of 200 mg hydroxychloroquine twice a day orally and 400 mg lopinavir with 100 mg ritonavir twice a day orally. […] We compared survival, mechanical ventilation-free survival, changes in C-reactive protein, respiratory function, and clinical status in a cohort of patients who received additional treatment with anakinra (either 5 mg/kg twice a day intravenously [high dose] or 100 mg twice a day subcutaneously [low dose]) with a retrospective cohort of patients who did not receive anakinra (referred to as the standard treatment group). […] Between March 17 and March 27, 2020, 29 patients received high-dose intravenous anakinra, non-invasive ventilation, and standard treatment. […] Between March 10 and March 17, 2020, 16 patients received non-invasive ventilation and standard treatment only and comprised the comparison group for this study. […] A further seven patients received low-dose subcutaneous anakinra in addition to non-invasive ventilation and standard treatment; however, anakinra treatment was interrupted after 7 days because of a paucity of effects on serum C-reactive protein and clinical status. […] At 21 days, treatment with high-dose anakinra was associated with reductions in serum C-reactive protein and progressive improvements in respiratory function in 21 (72%) of 29 patients; five (17%) patients were on mechanical ventilation and three (10%) died. […] In the standard treatment group, eight (50%) of 16 patients showed respiratory improvement at 21 days; one (6%) patient was on mechanical ventilation and seven (44%) died. […] At 21 days, survival was 90% in the high-dose anakinra group and 56% in the standard treatment group (p=0·009). […] Mechanical ventilation-free survival was 72% in the anakinra group versus 50% in the standard treatment group (p=0·15). […] Bacteraemia occurred in four (14%) of 29 patients receiving high-dose anakinra and two (13%) of 16 patients receiving standard treatment. […] In this retrospective cohort study of patients with COVID-19 and ARDS managed with non-invasive ventilation outside of the ICU, treatment with high-dose anakinra was safe and associated with clinical improvement in 72% of patients. | 2020-06-08 |
| 32501511 | To define pediatric-specific dosing regimens for hydroxychloroquine and remdesivir for COVID-19 treatment. […] The primary outcome for hydroxychloroquine was average unbound plasma concentrations for 5 treatment days. […] This analysis provides pediatric-specific dosing suggestions for hydroxychloroquine and remdesivir and raises concerns regarding hydroxychloroquine use for COVID-19 treatment because concentrations were less than those needed to mediate an antiviral effect. | 2020-06-13 |
| 32501538 | However, there is no specific antiviral treatment for COVID-19. […] Patients were divided into two groups according to different treatment plans (danoprevir and lopinavir/ritonavir). […] Indexes like blood routine, inflammation and immune-related indexes were significantly recovered after treatment. […] Collectively, applying danoprevir is a good treatment plan for COVID-19 patients. | 2020-06-24 |
| 32501754 | The coronavirus disease 2019 (COVID-19) pandemic is exacting a disproportionate toll on ethnic minority communities and magnifying existing disparities in health care access and treatment. | 2020-06-19 |
| 32501807 | However, 188 (85%), 165 (74%), and 127 (57%) oncologists preferred the virtual prescription of hormonal therapy, bone modifying agents, and targeted therapy, respectively. […] Overall, 118 (53%) respondents preferred to continue first-line palliative treatment, in contrast to 68 (30%) and 47 (21%) respondents indicating a preference to interrupt second- and third-line palliative treatment, respectively. | 2020-06-25 |
| 32501808 | Additionally, the time distributions of tweets containing information about dental services, needs of dental treatment, and home oral care during the COVID-19 epidemic were further analyzed. […] The distributions of tweets containing information about dental services, needs of dental treatment, and home oral care information dynamically changed with time. | 2020-06-23 |
| 32501839 | The electronic medical record was queried for patient age, type and mechanism of injury, location where injury was sustained, presence of domestic violence, length of inpatient hospital stays and treatment rendered. […] The two 3-week periods were then comparatively analyzed to determine differences and trends in these variables. and treatment rendered. | 2020-06-19 |
| 32502008 | Massage is used as an alternative therapy. […] We will search the randomized controlled trials related to acupuncture therapy and postoperative anorectal diseases from inception to January 2020. | 2020-06-16 |
| 32502034 | Thirty-three severe patients with a median age of 66 years (range, 33-82 years, IQR, 57-76) were treated in intensive care units; out of these patients, 66.7% (22) were men and 19 (57.5%) had chronic diseases, including hypertension, diabetes, heart failure, stroke, and renal insufficiency. | 2020-06-16 |
| 32502054 | The patient was admitted to hospital and treated symptomatically with oral medication. | 2020-06-16 |
| 32502282 | During the EM clerkship, students play an integral role in interviewing patients, formulating treatment plans, facilitating patient discharges, and counseling patients. | 2020-06-19 |
| 32502288 | Early detection and definitive surgical treatment are key to improving MM prognosis, and in England there is a suspected skin cancer referral pathway that facilitates specialist Dermatology assessment within two weeks. | 2020-06-19 |
| 32502303 | 1] An appeal for adherence to therapy was shared among rheumatologists, but special attention should be paid to pregnant women who suffer from RDs. | 2020-06-05 |
| 32502389 | For each scenario, we projected estimated new cases over time, patients requiring inpatient and critical care (ie, admission to the intensive care units [ICU]) treatment, and deaths, and compared the effect of each intervention on the basic reproduction number, R0. | 2020-06-08 |
| 32502594 | This recognition has led to the urgent need for practical guidance regarding prevention, diagnosis, and treatment of VTE. […] A group of approved panelists developed key clinical questions by using the PICO (Population, Intervention, Comparator, Outcome) format that addressed urgent clinical questions regarding the prevention, diagnosis, and treatment of VTE in patients with COVID-19. | 2020-06-26 |
| 32502659 | They may have a potential role as adjunctive therapy to mitigate the effects of endothelial dysfunction and dysregulated inflammation in patients with COVID-19 infection. | 2020-06-12 |
| 32502796 | RT-PCR testing for SARS-CoV-2 prior to treatment was reported by 44.8% of the institutions. […] The estimated time interval between diagnosis and treatment initiation increased for about 20% of institutions. […] Indications for primary systemic therapy were modified in 56% (211/377), with upfront surgery increasing from 39.8% to 50.7% (p < 0.002) and from 33.7% to 42.2% (p < 0.016) in T1cN0 triple-negative and ER-negative/HER2-positive cases, respectively. […] In luminal-A tumours, a large majority (68%) recommended endocrine treatment to postpone surgery. […] Postoperative radiation therapy was postponed in 20% of the cases. | 2020-06-26 |
| 32502882 | Eligible patients using renin-angiotensin system blockers (ACEI/ARBs) with a confirmed diagnosis of COVID-19 will be randomized to a strategy of continued ACEI/ARB treatment versus temporary discontinuation for 30 days. […] SUMMARY: BRACE CORONA will evaluate whether the strategy of continued ACEI/ARB therapy compared with temporary discontinuation of these drugs impacts clinical outcomes among patients with COVID-19. | 2020-06-26 |
| 32502901 | This research proposes RPs extracted from bacillus sp. and yeast as new forum for the advancement of antiviral therapy. […] Hitherto, antiviral therapy with RPs-involving viral infection has not been widely investigated as critical targets. […] Also, exploring antiviral strategy based on RPs could be a promising guide for more potential therapeutics. | 2020-06-16 |
| 32503061 | Homeopathic symptoms from this case series were collected from 18 consecutive patients who, in addition to their concurrent conventional treatment or traditional Chinese medicine, actively sought help from homeopathy as an adjunctive measure for symptomatic relief from COVID-19. | 2020-06-06 |
| 32503092 | After treatment, both patients recovered from pneumonia and neither patient experienced new attacks due to predisposing SARS-CoV-2 infection in the following 2 months. | 2020-06-11 |
| 32503117 | Some of these issues include the lack of a detailed understanding of the viral and participating host factors in completing the virus life cycle, in mediating disease pathogenesis or protection from disease, and in activating or suppressing host innate and cellular immunity against virus infection, as well as of the animal models required for testing vaccines and therapeutics. | 2020-06-08 |
| 32503382 | The identification of effective laboratory biomarkers able to classify patients based on their risk is imperative in being able to guarantee prompt treatment. | 2020-06-12 |
| 32503620 | Patients of both groups will be treated under optimal treatment based on the CDC and WHO guidelines and national consensus proposed in Iran including the same dosages of Lopinavir/Ritonavir, antibiotics, trace elements and antioxidants while only in group-B patients Colchicine will be added on top of this protocol. […] Primary: Time for clinical improvement and lung CT score changes 14 days after treatment. […] Secondary: 14 days after treatment - C-Reactive Protein test x Neutrophil to Lymphocyte Ratio , Interleukin-6, malondialdehyde (MDA) levels reduction - Percentage of patients who require supplemental Oxygen - Mean hospital stay length RANDOMISATION: Patients will be allocated to each group (ratio 1:1) by using an online randomization tool: http://www.graphpad.com/quickcalcs/index.cfm BLINDING (MASKING): This will be a double-blind study in which participants and those assessing the final outcomes will be blinded to group assignment. | 2020-06-08 |
| 32503657 | We will enroll patients who are discharged after treatment, whose nucleic acid test has changed from negative to positive during the screening visit, regardless of the severity of the symptoms, to investigate the mechanism, clinical outcome and therapeutic efficacy with Favipiravir patients with Corona virus Disease 2019. […] Favipiravir is an anti-viral agent that selectively and potently inhibits the RNA-dependent RNA polymerase, it has been used for treatment of some life-threatening infections such as Ebola virus, Lassa virus and rabies. […] After the first diagnosis and treatment of COVID-19, the nucleic acid test of respiratory specimens such as sputum or nasopharyngeal swabs, has been negative for two consecutive times (sampling time interval of at least 24 hours), in accordance with the COVID-19’s diagnosis and treatment Plan (7th Edition), discharged.3. […] Favipiravir group (experimental): Favipiravir 1600mg each dose, twice a day on the 1st day; 600mg each dose, twice a day from the 2nd to the 7th day, Oral administration, the maximum number of days taken will be no more than 14 days plus routine treatment for COVID-19. […] Regular treatment group (control): Treatments other than Antiviral drugs can be given. […] Routine treatment for patients with the corona virus will be administered, this includes oxygen therapy, drugs that reduced phlegm and relieve cough, including thymosin, proprietary Chinese medicine, etc. […] Trial participants, investigators, care givers, outcome assessors, and date analysts are not blinded to group assignment. 210 patients are expected to be enrolled and allocated according to the ratio of 2 (Favipiravir group, n=140): 1(regular treatment group, n=70). | 2020-06-08 |
| 32503662 | The hypothesis of the study is that treatment with hydroxychloroquine sulphate in hospitalised patients with coronavirus disease 2019 (Covid-19) is safe and will accelerate the virological clearance rate for patients with moderately severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) when compared to standard care. […] Furthermore, we hypothesize that early treatment with hydroxychloroquine sulphate is associated with more rapid resolve of clinical symptoms as assessed by the National Early Warning Score 2 (NEWS2), decreased admission rate to intensive care units and mortality, and improvement in protein biomarker profiles (C-reactive protein, markers of renal and hepatic injury, and established cardiac biomarkers like cardiac troponin and B-type natriuretic peptide). […] The study is a two-arm, open label, pragmatic randomised controlled group sequential adaptive trial designed to assess the effect on viral loads and clinical outcome of hydroxychloroquine sulphate therapy in addition to standard care compared to standard care alone in patients with established Covid-19. […] The pragmatic approach will enable swift initiation of randomisation and allocation to treatment. […] Clinical data, including standard hospital biochemistry, medical therapy, vital signs, NEWS2, and microbiology results (including blood culture results and reverse transcriptase polymerase chain reaction [RT-PCR] for other upper airway viruses), will be automatically extracted from the hospital electronic records and merged with the study specific database. […] The virologist assessing viral load in the oropharyngeal samples and the statistician responsible for analysis of the data will be blinded to the treatment allocation for the statistical analyses. | 2020-06-08 |
| 32503663 | Patients were excluded from the trial in case of (1) known serious allergic reactions to yeast-derived products, (2) lithium carbonate therapy, (3) mechanical ventilation prior to randomization, (4) peripheral white blood cell count above 25.000/μL and/or active myeloid malignancy, (5) high dose systemic steroid therapy (> 20 mg methylprednisolone or equivalent), (6) enrolment in another investigational study, (7) pregnant or breastfeeding or (8) ferritin levels > 2000 μg/mL. […] The primary endpoint of this intervention is measuring oxygenation after 5 days of inhaled (and intravenous) treatment through assessment of a change in pretreatment and post-treatment ratio of PaO2/FiO2 and through measurement of the P(A-a)O2 gradient (PAO2= Partial alveolar pressure of oxygen, PaO2=Partial arterial pressure of oxygen; FiO2= Fraction of inspired oxygen). | 2020-06-08 |
| 32503806 | Investigators quickly turned to regulatory bodies to simplify treatment schedules, facilitate telemedicine and to decrease required data collection Going forward the oncology research community must use the lessons learned to focus on redesigning studies to ensure that the critical scientific questions are answered safely while expanding access and increasing partnerships with community physicians. | 2020-06-06 |
| 32503814 | Since then, thousands of people have suffered and died, making the need for a treatment of severe acute respiratory syndrome-related coronavirus-2 (SARS-CoV-2) more crucial than ever. […] The results support the combination of copper, N-acetylcysteine (NAC), colchicine and nitric oxide (NO) with candidate antiviral agents, remdesivir or EIDD-2801, as a treatment for patients positive for SARS-CoV-2. […] The authors propose to study the effects of the combination of copper, NAC, colchicine, NO and currently used experimental antiviral agents, remdesivir or EIDD-2801, as a potential treatment scheme for SARS-COV-2. | 2020-06-22 |
| 32503815 | This article demonstrates the importance of IL6 in progression of disease and the possibility of inhibition of IL6 signaling in COVID-19 therapy. | 2020-06-22 |
| 32503816 | The Covid-19 pandemic is a world-wide crisis without an effective therapy. […] While most approaches to therapy are using repurposed drugs that were developed for other diseases, it is thought that targeting the biology of the SARS-CoV-2 virus, which causes Covid-19, can result in an effective therapeutic treatment. […] The evidence reviewed here suggests that oral recombinant methioninase could be a promising treatment for coronavirus patients. | 2020-06-22 |
| 32503817 | Thus, it is extremely necessary to identify new drugs suitable for the treatment of the 2019-nCoV outbreak. […] Herein, we recapitulate these experimental studies to highlight the use of antiviral drugs for the treatment of SARS-Cov-2 disease. | 2020-06-22 |
| 32503818 | Furthermore, trainee’s mental health should be safeguarded, and medical students can be involved in the COVID-19 clinical treatment if needed. | 2020-06-22 |
| 32503820 | The range of ocular manifestations, either as a result of the infection or as a result of the treatment, has not yet been discussed. | 2020-06-22 |
| 32503821 | It is probably no accident that a sequence from the SARS-CoV-2 orf1b gene is found in the human NTNG1 gene, implicated in schizophrenia, and that haloperidol, used to treat schizophrenia, may also be a treatment for COVID-19. […] These analogs might be valuable in the treatment of COVID-19 and other coronavirus infections. | 2020-06-22 |
| 32503825 | Breast Cancer (BC) patients are concerned both with BC treatment and COVID-19. […] BC and SBL analysis showed no difference in pre-treatment characteristics (p>0.05). | 2020-06-22 |
| 32503826 | Temporary recommendations are needed that could assist specialists in preventing COVID-19 infection and optimizing resources for diagnosis and treatment of BC patients. | 2020-06-22 |
| 32503874 | The secondary endpoints will be proportion of participants relieved from clinical symptoms defined at the time (in hours) from initiation of the study treatment, all-cause mortality, discharged date, frequency of respiratory progression and treatment-emergent adverse events. | 2020-06-16 |
| 32503877 | Over a 10-14 day treatment course, acalabrutinib improved oxygenation in a majority of patients, often within 1-3 days, and had no discernable toxicity. […] At the end of acalabrutinib treatment, 8/11 (72.7%) patients in the supplemental oxygen cohort had been discharged on room air, and 4/8 (50%) patients in the mechanical ventilation cohort had been successfully extubated, with 2/8 (25%) discharged on room air. | 2020-06-19 |
| 32504106 | The incidence of deep vein thrombosis (DVT) in CoViD-19 patients in intensive care units (ICU) has so far been investigated in only a few studies. | 2020-06-09 |
| 32504637 | Moreover the patients hospitalized in high-intensity care unit showed significantly elevated MDW respects to middle or low symptomatic one, suggest including this parameter as prognostic marker or of therapy efficacy, integrated with other laboratory findings. | 2020-06-27 |
| 32504757 | In light of the outbreak of the 2019 novel coronavirus disease (COVID-19), the international scientific community has joined forces to develop effective treatment strategies. | 2020-06-28 |
| 32504923 | We hypothesize that NAC could act as a potential therapeutic agent in the treatment of COVID-19 through a variety of potential mechanisms, including increasing glutathione, improving T cell response, and modulating inflammation. […] In this article, we present evidence to support the use of NAC as a potential therapeutic agent in the treatment of COVID-19. | 2020-06-16 |
| 32505066 | We suggest a possible role of loss of bridging between innate and adaptive immunity in COVID-19 and a potential treatment modality also discussed. | 2020-06-26 |
| 32505070 | It is proposed that nebulized lidocaine might be beneficial in reducing cytokines, protecting patients’ lungs and improving outcomes in COVID-19 patients when administered via inhalation as an adjunctive treatment for severe respiratory symptoms in patients fighting the novel Coronavirus. | 2020-06-28 |
| 32505072 | This approach, which can be expressed in terms of picotechnology, makes it possible to identify living cell types or in general, chemical and biological surfaces using their atomic arrays, and applied for early diagnosis even treatment of the disease. | 2020-06-26 |
| 32505076 | We also describe clinical and demographic factors associated with poor prognosis and Covid-19 treatment outcomes. […] We also described Covid-19 treatment outcome, mortality and associated risk factors using univariate and multivariate logistic regression analysis. 17/1878 total diagnosis in our center had lung cancer (0.9 %) versus 1878/320,000 of the total reference population (p = 0.09). 9/17 lung cancer patients with Covid-19 diagnosis died (52.3 %) versus 192/1878 Covid-19 patients in our center (p < 0.0001). […] Combined treatment with hydroxychloroquine and azithromycin improves the outcome of Covid-19 in lung cancer patients, detecting only 1/6 deaths between patients under this treatment versus others treatment, with statistical significance in the univariate and multivariate logistic regression (OR 0.04, p = 0.018). […] Combined hydroxychloroquine and azithromycin treatment seems like a good treatment option. | 2020-06-26 |
| 32505462 | She was transferred to ICU and administered multiple treatment according to the disease progression and chest CT manifestations. | 2020-06-17 |
| 32505643 | Family meetings are fundamental to the practice of palliative medicine and serve as a cornerstone of intervention on the inpatient palliative care consultation service. […] We describe implementation of telemedicine to facilitate electronic family (e-family) meetings to facilitate in-patient palliative care. […] Of 67 scheduled meetings and performed by the palliative care service, only 2 meetings were aborted for a 97% success rate of scheduled meetings occurring. | 2020-06-11 |
| 32505658 | As we begin to emerge from the crisis, we will need to manage the backlog of nonemergency neurosurgical patients whose treatment has been delayed and remain responsive to further possible surges of SARS-CoV-2 infections. | 2020-06-16 |
| 32505805 | The primary outcome measures were COVID-19 requiring oxygen (oxygen therapy or noninvasive ventilation) and critical COVID-19 (requiring invasive mechanical ventilation or extracorporeal membrane oxygenation, ECMO). […] By April 14, among the 617 pregnant women with COVID-19, 93 women (15.1 %; 95 %CI 12.3-18.1) had required oxygen therapy and 35 others (5.7 %; 95 %CI 4.0-7.8) had had a critical form of COVID-19. | 2020-06-21 |
| 32505811 | With the exponential surge in coronavirus disease 2019 (COVID-19) patients worldwide, the resources needed to provide continuous kidney replacement therapy (CKRT) for patients with acute kidney injury or kidney failure may be threatened. | 2020-06-11 |
| 32505821 | The therapeutic effect for PDL treatment on COVID-19 was validated by the TCMATCOV (TCM Anti COVID-19) platform. | 2020-06-26 |
| 32505908 | A multiple sclerosis patient infected by SARS-CoV-2 during fingolimod therapy was hospitalized with moderate clinical features, and recovered in 15 days. | 2020-06-26 |
| 32506111 | This document prepared for our nation by the Bangladesh Society of Cardiovascular Interventions (BSCI) is intended to serve as a clinical practice guideline for cardiovascular health care professionals, with a focus on modifying standard practice of care during the COVID-19 pandemic, in order to ensure continuation of adequate and timely treatment of cardiovascular emergencies avoiding hospital-based transmission of SARS-COV-2 among healthcare professionals and the patients. […] This guideline is limited to the provision of cardiovascular care, and it is expected that specific targeted pharmaco-therapeutics against SARS-CoV-2 be prescribed as stipulated by the National Guidelines on Clinical Management of Corona virus Disease 2019 (COVID-19) published by the Director General of Health Services, Ministry of Health and Family Welfare of Bangladesh. | 2020-06-09 |
| 32506122 | Non-respiratory complications are common, suggesting that the treatment of respiratory conditions needs to be combined with strategies to prevent and mitigate the effects of non-respiratory complications. | 2020-06-26 |
| 32506142 | Among the 1397 chest CT scans performed during the pandemic period from 1 March 2020 to 10 May 2020, in two centres with orthopaedic surgery, we selected all the 118 thoracic or chest CT performed for patients who presented to the Emergency Department of the hospital with a diagnosis of trauma for orthopaedic surgical treatment. | 2020-06-11 |
| 32506258 | A comprehensive document with 46 statements are presented, including protection of medical personnel, etiological treatment, diagnosis and treatment of tissue and organ functional impairment, psychological interventions, immunity therapy, nutritional support, and transportation of critically ill COVID-19 patients. […] Dynamic monitoring and supportive treatment for the restoration of tissue vascularization and organ function are particularly important. | 2020-06-11 |
| 32506699 | None of the patients had severe complications or required intensive care treatment, and all of them temporarily discontinued ongoing ts/bDMARDs therapy. […] Almost all patients adopted precautions to prevent the contagion (90.6%) and maintained the ongoing treatment with ts/bDMARDs (93.2%). | 2020-06-19 |
| 32506726 | Increasingly, confirmed patients being discharged according to the current diagnosis and treatment protocols, follow-up of convalescent patients is important to knowing about the outcome. | 2020-06-19 |
| 32506768 | Between March 18, 2020 and April 5, 2020, 18 patients admitted with COVID-19 who has BPH and are using medication for this were included in the study and analysed retrospectively. […] Standard COVID-19 treatment protocol determined by our Ministry of Health was applied to all patients according to their risk groups. | 2020-06-23 |
| 32506862 | To evaluate the effectiveness and safety of Jinhua Qinggan granules in the treatment of patients with novel coronavirus pneumonia (COVID-19). […] All 80 patients received symptomatic and supportive treatment. […] Among them, 44 patients took Jinhua Qinggan granules (treatment group) within 24 h of admission, and the remaining 36 patients either did not take Jinhua Qinggan granules or took the granules for less than 2 d (control group). […] Of the two groups, 56.82% in the Jinhua Qinggan treatment group and 27.78% in the control group demonstrated negative nucleic acid tests within 7 d or less. […] No adverse reactions were found in the treatment group after taking this medicine. | 2020-06-22 |
| 32506865 | The TCM protocol in the Diagnosis and Treatment Protocol for corona virus disease 2019 (COVID-19) (Trial Version 7) has been updated from previous versions. | 2020-06-22 |
| 32507060 | The use of chronological age is an unjustified threshold for the creation of public policies to control the spreading of the virus; doing so reinforces intrapersonal and interpersonal negative age stereotypes and violates older persons’ human rights to autonomy, proper care treatment, work, and equality. | 2020-06-25 |
| 32507113 | This change allowed our subspecialist providers to review charts quickly to optimize potential therapy and management during the patient surge. | 2020-06-25 |
| 32507520 | In this review, we specify physiopathological mechanisms of each phase of COVID-19 - viral, immune and pro-thrombotic - notably because they involve different treatment. | 2020-06-25 |
| 32507536 | Of the deceased, only 6 patients (40%) were in active treatment. […] No specific treatment was established in 40% (6/15) of the patients. | 2020-06-11 |
| 32507543 | In this review, we summarize the current epidemiological status of COVID-19 and consider the virological and immunological lessons, animal models, and tools developed in response to prior SARS-CoV and MERS-CoV outbreaks that can serve as resources for development of SARS-CoV-2 therapeutics and vaccines. | 2020-06-15 |
| 32507556 | The results reviewed here highlight the importance of considering and further investigating the impact of the current pandemic on the diagnosis and treatment of panic disorder (alone or comorbid with the COVID-19). | 2020-06-11 |
| 32507557 | In France and around the world, centers practicing electroconvulsive therapy (ECT) have seen their activity decrease, or even stop for many reasons. | 2020-06-11 |
| 32507625 | Finally, 47% of the respondents believed that the accumulated workload could be dealt with in a timely manner after the COVID-19 outbreak, but 50% thought the postponement of urological services would affect the treatment and survival outcomes of their patients. | 2020-06-16 |
| 32507686 | Advances in treating and preventing Alzheimer disease and other neurocognitive disorders of aging arise from rigorous preclinical and clinical research, with randomized controlled treatment trials as the last and definitive test. | 2020-06-11 |
| 32507746 | In the present study, we devised a mathematical model focusing on the treatment of people complaining of influenza-like-illness (ILI) symptoms, potentially at risk of contracting COVID-19 or other emerging/re-emerging respiratory infectious agents during their admission at the health-care setting, who will occupy the detection kits causing a severe shortage of testing resources. | 2020-06-25 |
| 32508022 | Although no effective treatment is formally approved for COVID-19 infection, support of ventilation with oxygen therapy and sometimes mechanical ventilation is often required. […] Treatment with systemic and/or local glucocorticoids might be helpful to alleviate the pulmonary inflammation and edema, which may decrease the development and/or consequences of ARDS. | 2020-06-11 |
| 32508041 | We summarized clinical phenomes of 3795 patients with COVID-19 based on 80 published reports from the onset of outbreak to March 2020 to emphasize the importance and specificity of those phenomes in diagnosis and treatment of infection, and evaluate the impact on medical services. | 2020-06-11 |
| 32508062 | All showed post treatment immediate improvements in gas exchange and/or hemodynamics. […] Treatment for COVID-19 pneumonia may warrant anticoagulation for milder cases and thrombolysis for more severe disease. | 2020-06-13 |
| 32508107 | In palliative care, we strive to provide care to the whole patient. […] Our New York City-based palliative care team has found that caring for patients’ loved ones has proven to be an even more important aspect of the care we have provided during the COVID epidemic. | 2020-06-08 |
| 32508168 | The complete lack of specific treatment forced clinicians to use old drugs, chosen for their efficacy against similar viruses or their in vitro activity. […] We aimed to provide a literature review on the putative effectiveness and safety of available treatments for COVID-19 in pregnant women.Methods: We reviewed all the available literature concerning the drugs that have been used in the treatment of COVID-19 during pregnancy and whose safe assumption during pregnancy had been demonstrated by clinical studies (i.e. including studies on other infectious diseases). | 2020-06-12 |
| 32508257 | Considering patients who had been enrolled before the pandemic, and who plan to take the study medication, the situation becomes complicated. | 2020-06-08 |
| 32508311 | Androgen suppression by androgen deprivation therapy and androgen receptor signaling inhibitors form the foundation of prostate cancer treatment. […] We also discuss the future directions and controversies that need to be addressed in order to establish the viability of targeting TMPRSS2 and/or ACE2 through androgen signaling regulation for COVID-19 treatment, particularly its relevance in the context of prostate cancer management. | 2020-06-08 |
| 32508329 | She was quarantined for total of 14 days and recovered successfully without any complications (no myasthenia exacerbation or crisis, no COVID-19 related complications), with no changes to her immunosuppressive therapy. […] Treatment of MG patients with COVID-19 needs to be tailored to individual patient. | 2020-06-18 |
| 32509205 | However, the information regarding treatment of severe and critical COVID-19 is limited. […] The current study reviewed published evidence of clinical interventions of severe and critical COVID-19, aiming to provide an up-to-date reference for further clinical treatment. | 2020-06-11 |
| 32509294 | COVID-19 is a new infectious disease worldwide, and its infectious source, transmission route, susceptible population, and therapy are not clear. | 2020-06-09 |
| 32509394 | On the one hand, almost all doctors participated in the treatment of patients of COVID-19. […] On the other hand, the government restricted residents to go out, and the sick people were also afraid of being infected with COVID-19 when seeking medical treatment. […] Whether cancer patients seek medical treatment or not has become a contradiction for a long time. | 2020-06-11 |
| 32509977 | Anxieties may be heightened by concerns over whether endometriosis may be an underlying condition that could predispose to severe COVID-19 infection and what constitutes an appropriate indication for presentation for urgent treatment in the epidemic. | 2020-06-09 |
| 32510142 | A return to normality is unlikely until effective therapeutics and a vaccine are available. […] In particular, we make a case for evaluation of the well-tolerated drugs miglitol, celgosivir and especially miglustat for the treatment of COVID-19. | 2020-06-08 |
| 32510155 | However, the patient deteriorated quickly in spite of optimal medical therapy making urgent aortic valve replacement necessary. | 2020-06-26 |
| 32510169 | This study aims to explore the clinical effect of Arbidol (ARB) combined with adjuvant therapy on patients with coronavirus disease 2019 (COVID-19). […] Various indexes in the two groups before and after treatment were observed and recorded, including fever, cough, hypodynamia, nasal obstruction, nasal discharge, diarrhea, C-reactive protein (CRP), procalcitonin (PCT), blood routine indexes, blood biochemical indexes, time to achieve negative virus nucleic acid, and so on. […] ARB combined with adjuvant therapy might be able to relieve the fever of COVID-19 sufferers faster and accelerate the cure time to some degree, hence it’s recommended for further research clinically. | 2020-06-19 |
| 32510173 | Data on epidemiological and clinical characteristics, laboratory findings, treatment procedures, and clinical outcomes were retrieved from electronic medical records. | 2020-06-19 |
| 32510283 | Here we investigate the impact of the coronavirus disease 2019 outbreak on stroke manifestations, treatment courses, the outcome of stroke patients, and the hospitalization rate in a referral center for stroke management in Tehran, Iran. […] Treatment approaches, duration of hospitalization, and mortality rates did not differ significantly. […] Although the pandemic did not affect the treatment plans and care of the patients, stroke cases with coronavirus disease 2019 had higher age, more large vessel ischemic stroke, and more severe stroke. | 2020-06-26 |
| 32510329 | We propose that a Global Immunological Observatory and associated developments in systems immunology, therapeutics and vaccine design should be at the heart of this enterprise. | 2020-06-26 |
| 32510340 | Timely detection and diagnosis are urgently needed to guide epidemiological measures, infection control, antiviral treatment, and vaccine research. | 2020-06-23 |
| 32510581 | Appropriate advice and positive treatment might be critical to the prognosis when dealing with these pregnant patients. […] Responsive medical advice and active treatment for those patients are critical to recovery. | 2020-06-08 |
| 32510734 | The devastating effects of the coronavirus designated severe acute respiratory syndrome coronavirus 2 (SARS-Cov-2) has led to urgent attempts to find effective therapeutic agents for inpatient and outpatient treatment of COVID-19. […] There is one clinical trial initiated, the individually-randomized, telemedicine-based, “Azithromycin for COVID-19 Treatment in Outpatients Nationwide (ACTION)” based at the University of California San Francisco. | 2020-06-19 |
| 32510748 | In the absence of an efficient drug treatment or a vaccine, the control of the COVID-19 pandemic relies on classic infection control measures. | 2020-06-27 |
| 32510771 | We reduced immunosuppressive regimen in all these patients, typically holding the antiproliferative agent and augmenting steroids; everybody received hydroxychloroquine, initial empiric antibiotic treatment with piperacillin/tazobactam, and high-dose low molecular weight heparin. | 2020-06-26 |
| 32510799 | This novel type has created a pandemia throughout the world most notably causing death owing to pneumonia.Nowadays the entire world is searching the curative treatment but outcomes are discouraging for intensive care critical patients. | 2020-06-19 |
| 32510978 | This may, in turn, inform the design of biomarkers predictive of disease course, as well as therapeutics targeting pathogenic endothelial responses. | 2020-06-08 |
| 32511042 | Severe restrictions have been imposed in most countries for oral health care to the general population, allowing treatment only for emergencies, because of the generation of aerosols during clinical procedures and to ration personal protective equipment (PPE) during the pandemic. | 2020-06-08 |
| 32511078 | Most seem to agree that a patient’s ability to benefit from treatment and to survive are first-order considerations. | 2020-06-08 |
| 32511100 | Of the 30,100,826 adults included in this study, the average age is 50 years, 15% have at least one specialty medication, and the average patient has 2 to 3 comorbidities. | 2020-06-24 |
| 32511148 | Additionally, an overuse of antimalarials for the treatment of COVID-19 could lead to shortages in our region. | 2020-06-08 |
| 32511171 | The literature addressing the palliative care response to COVID-19 has surged, and yet, there is a critical gap regarding the unique contributions of palliative nurses and their essential role in mitigating the sequelae of this crisis. | 2020-06-08 |
| 32511678 | There was no statistical difference between ACEIs and ARBs groups in terms of hospital admission rate, oxygen therapy and need for non-invasive ventilation. […] Patients chronically treated with RAAS inhibitors showed a significantly lower rate of admission to semi-intensive/intensive care units, when compared to the non-RAAS population (odds ratio [OR] 0.25, CI95% 0.09-0.66 p=0.006). | 2020-06-26 |
| 32511724 | Preparedness of health workers and health services is crucial to tackle the enormous challenge posed by SARS-CoV-2 in wards, operating theatres, intensive care units, and interventionist laboratories. | 2020-06-23 |
| 32511744 | The spread of novel coronavirus disease (COVID-19) urged a never-seen coordinated global response to prepare the health system, including primary care, hospital facilities and intensive care units (ICUs). | 2020-06-19 |
| 32511784 | Given the huge influence caused by the overwhelming COVID-19 pandemic affecting over three million people worldwide, a wide spectrum of drugs is considered for the treatment in the concept of repurposing and off-label use. | 2020-06-19 |
| 32511951 | Around the world, recommendations for cancer treatment are being adapted in real time in response to the pandemic of COVID-19. […] We propose treatment recommendations related to COVID-19 for the different stages of hepatocellular carcinoma (ie, 0, A, B, and C), specifically in relation to surgery, locoregional therapies, and systemic therapy. […] We suggest potential strategies to modify risk during the pandemic and aid multidisciplinary treatment decision making. | 2020-06-11 |
| 32511971 | The characteristics of laboratory findings of coronavirus are of great significance for clinical diagnosis and treatment. | 2020-06-27 |
| 32512073 | As the backlog of patients waiting to start treatment will inevitably grow, some insight on how to proactively manage this issue will also be described. | 2020-06-27 |
| 32512089 | Currently, approved treatment modalities consist of only supportive care and oxygen supplementation. | 2020-06-27 |
| 32512122 | Irrespective of etiology, patients with acute myocardial injury should be prioritized for treatment. […] Randomized trials are urgently needed to investigate treatment modalities to reduce the incidence and mortality associated with COVID-19 related acute myocardial injury. | 2020-06-11 |
| 32512133 | The epidemiological, demographic, clinical, laboratory, treatment, and outcome data were collected from electronic medical records and compared between the good-sleep group and poor-sleep group. […] There were no significant between-group differences regarding demographic and baseline characteristics, as well as laboratory parameters upon admission and in-hospital treatment. | 2020-06-14 |
| 32512271 | Although development of novel vaccines can prevent the SARS CoV-2 infections, it is still impeded by several other factors and therefore novel approaches towards treatment and management of this disease is the urgent need. […] We provide an overall importance for the use of monoclonal chicken egg yolk antibodies (IgY) using phage display method describing their potential passive immunotherapeutic application for the treatment and prevention of SARS CoV-2 infection which is simple, fast and safe way of approach for treating patients effectively. | 2020-06-23 |
| 32512289 | This hypothesis has consequences for treatment of patients, evaluation of personal and herd immunity and vaccine development. | 2020-06-16 |
| 32512291 | The active-treatment arm will receive valsartan in a dosage titrated to blood pressure up to a maximum of 160 mg bid, and the placebo arm will receive matching placebo. […] Treatment duration will be 14 days, or until the occurrence of the primary end point or until hospital discharge, if either of these occurs within 14 days. […] The results of this study might impact the treatment of SARS-CoV-2 patients globally. | 2020-06-26 |
| 32512383 | Here, a potential radiation-mediated CS regulation is raised by reevaluating the radiation-mediated pneumonia control in the 1920s, with the following latent advantages of lung radiotherapy (LR) in treatment of COVID-19: (1) radiation accesses poorly circulated tissue more efficiently than blood-delivered medications; (2) low-dose radiation (LDR)-mediated metabolic rewiring and immune cell activation inhibit virus loading; (3) pre-consumption of immune reserves by LDR decreases CS severity; (4) higherdose radiation (HDR) within lung-tolerable doses relieves CS by eliminating in situ overactive cytokine-releasing cells. | 2020-06-24 |
| 32512472 | Ketogenic diet therapy is often started in the hospital, with families educated in hospital-based classes, but this is difficult to do in this current pandemic. […] At our two academic centers, both our pediatric and adult epilepsy diet centers have had to quickly consider alternative methods to both start and maintain ketogenic diet therapy. […] This paper provides several examples of how ketogenic diet therapy can be provided to patients in unique ways, along with recommendations from other experts and patients, learned over the past few months. | 2020-06-26 |
| 32512490 | Zn may also act in a synergistic manner when co-administered with the standard antiviral therapy, as was demonstrated in patients with hepatitis C, HIV, and SARS-CoV-1. […] Therefore, it may be hypothesized that Zn supplementation may be of potential benefit for prophylaxis and treatment of COVID-19. | 2020-06-26 |
| 32512702 | Moreover, the management of chronic neurological diseases, such as Multiple Sclerosis (MS), underwent guided modifications, such as an Extended Interval Dose (EID) of Disease-Modifying Treatment (DMT) administration, in order to minimize patients’ exposure to the health system, thus reducing the risk of SARS-CoV-2 infection. | 2020-06-09 |
| 32512988 | The role of non-invasive ventilation (NIV), high flow nasal cannula (HFNC) or continuous positive airway pressure devices (C-PAP) in the treatment of the 2019 corona virus disease (COVID-19) is not yet clear. […] We hereby report a case of a 44-year-old COVID-19 positive male patient suffering from hypoxic respiratory failure that was successfully treated with high flow nasal cannula oxygen therapy in a negative pressure intensive care room. | 2020-06-16 |
| 32513231 | Dual therapy by combining appropriate doses of these two medications with diverse activities against COVID-19 is expected to be better than monotherapy with hydroxychloroquine. […] Dual therapy - Hydroxychloroquine 400 mg taken orally every 12 hours for two days and then 200 mg taken orally every 12 hours for four days + Nitazoxanide 500 mg orally every 6 hours taken with food, for seven days. […] Patients will be randomly allocated using allocation papers and opaque sealed envelopes to either receive the placebo or the dual therapy intervention treatment in a 1:1 ratio until we have recruited the required number of patients for each group. […] Trial participants will be blinded. 86 participants will be randomized to each group, with 43 in the control group and 43 in the dual therapy group. | 2020-06-11 |
| 32513287 | The recommendations on emergency surgery have fueled a debate among surgeons on an international level.We maintain that laparoscopic cholecystectomy remains the treatment of choice for acute cholecystitis, even in the COVID-19 era. | 2020-06-23 |
| 32513289 | The primary objective is to determine the efficacy of a single dose of ivermectin, administered to low risk, non-severe COVID-19 patients in the first 48 hours after symptom onset to reduce the proportion of patients with detectable SARS-CoV-2 RNA by Polymerase Chain Reaction (PCR) test from nasopharyngeal swab at day 7 post-treatment. […] To assess the efficacy of ivermectin to reduce the SARS-CoV-2 viral load in the nasopharyngeal swab at day 7 post treatment.2. […] Participants will be randomized to receive a single dose of 400 μg/kg ivermectin or placebo, and the number of patients in the treatment and placebo groups will be the same (1:1 ratio). […] Ivermectin will be administered to the treatment group at a 400μg/Kg dose (included in the EU approved label of Stromectol and Scabioral). […] Primary Proportion of patients with a positive SARS-CoV-2 PCR from a nasopharyngeal swab at day 7 post-treatment. […] The sample size is 24 patients: 12 participants will be randomised to the treatment group and 12 participants to the control group. | 2020-06-11 |
| 32513290 | Exclusion criteria are: 1) previous allergic reaction to plasma exchange or its ingredients (i.e., sodium citrate), 2) two consecutive negative RT-PCR tests for SARS-CoV-2 at least 24 hours apart, 3) mild COVID-19 not requiring ICU admission and 4) terminally ill patients receiving palliative care. […] The intervention group will receive TPE, plus empiric treatment for COVID-19. […] The comparators are controls not receiving TPE but usual empiric treatment for COVID-19 as per institutional, national and international recommendations. […] A web-based randomization service, randomize.net, is used to allocate patients to their respective strata prior to the intervention or control therapy. | 2020-06-11 |
| 32513299 | The aim of this study is to evaluate the efficacy and safety of Anluohuaxian in the treatment of pulmonary fibrosis in patients with severe COVID-19. […] Confirmed COVID-19, and the nucleic acid test of respiratory specimens such as sputum or nasopharyngeal swabs is negative twice after the treatment (sampling interval is at least 24 hours);2. […] Brands can be selected according to the treatment routines of each research center to facilitate the improvement of treatment compliance. […] Trial participants, investigators, care givers, outcome assessors, and date analysts are not blinded to group assignment. 750 patients are expected to be enrolled and the cases are allocated according to the ratio of 2 (Anluohuaxian combined with regular treatment group):1 (regular treatment group). | 2020-06-11 |
| 32513308 | *Use of remdesivir as treatment for COVID-19 is permitted. […] The investigational treatment is anti-SARS-CoV-2 human convalescent plasma. […] To procure the investigational treatment, volunteers who recovered from COVID-19 will undergo testing to confirm the presence of anti-SARS-CoV-2 antibody to the spike trimer at a 1:400 dilution. […] Hospitalized, requiring high-flow oxygen therapy or non-invasive mechanical ventilation 6. […] A recent clinical trial evaluating the efficacy and safety of lopinavir- ritonavir for patients hospitalized with severe COVID-19 used a similar ordinal scale, as have recent clinical trials of novel therapeutics for severe influenza, including a post-hoc analysis of a trial evaluating immune plasma. […] Treatment assignments will be generated using randomly permuted blocks of different sizes to minimize imbalance while also minimizing predictability. […] The study participants and the clinicians who will evaluate post-treatment outcomes will be blinded to group assignment. | 2020-06-23 |
| 32513393 | In the absence of adequate diagnosis and treatment of SCC and melanoma in the current lockdown situation in Spain, we can expect to see to a considerable increase in large and thick SCCs and melanomas. | 2020-06-12 |
| 32513532 | However, there are no effective prophylactics or therapeutics available. […] CSE treatment significantly elevated ACE2 expression in human brain vessels. | 2020-06-25 |
| 32513593 | The current severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) outbreak poses a major challenge in the treatment decision-making of patients with cancer, who may be at higher risk of developing a severe and deadly SARS-CoV-2 infection compared with the general population. […] To guide our clinical decisions at the National Cancer Institute of Milan (Lombardy region, the epicenter of the outbreak in Italy), we formulated Coronavirus-adapted institutional recommendations for the systemic treatment of patients with gastrointestinal cancers. | 2020-06-12 |
| 32513653 | In patients requiring rescue therapy, infliximab with continuing steroids was recommended. […] Post-ASUC maintenance therapy was dependent on SARS-CoV-2 status but, in general, biologics were more likely to be deemed appropriate than azathioprine or tofacitinib. | 2020-06-27 |
| 32513664 | Between 16% (27/165) (before surgery) and 25% (26/102) (before medical treatment) did not perform any tests to rule out COVID-19 infection among patients. […] The majority of respondents did not alter indications of treatment if patients were COVID-19-negative, while treatments were generally postponed in COVID-19-positive patients. […] Treatment of early stage low-grade endometrioid endometrial cancer was deferred according to 49% (91/187) of respondents, with hormonal treatment as the option of therapy (31%; 56/178). […] A total of 77% (136/177) of respondents reported no changes in (surgical) treatment for early stage cervical cancer in COVID-19-negative patients, while treatment was postponed by 54% (96/177) of respondent, if the patient tested COVID-19-positive. […] Neoadjuvant chemotherapy for advanced ovarian cancers was considered by over one-third of respondents as well as hypofractionation of radiation treatment for locally advanced cervical cancers. […] COVID-19 affected the treatment of gynecologic cancers patients, both in terms of prioritization and identification of strategies to reduce hospital access and length of stay. | 2020-06-24 |
| 32513678 | In 2020, during the first months of the COVID-19 pandemic, a letter from a palliative care doctor to his patient was read out as part of an online campaign entitled #ReadALetter, organised by the organisation Letters Live. | 2020-06-09 |
| 32513791 | Moreover those biologics were originally investigated by Rheumatologists for the treatment of numerous rheumatic conditions, including macrophage activating syndrome (MAS), a similar form of storm that resembles the one occurring in COVID-19 patients (3). | 2020-06-09 |
| 32513807 | Because of their potential to influence immune response, ascorbic acid (vitamin C), zinc, vitamin D, and N-acetylcysteine have been hypothesized to be useful for prevention or treatment of COVID-19. | 2020-06-11 |
| 32513850 | Thus, understanding the immune response to SARS-CoV-2 is of the utmost importance for developing and testing vaccines and therapeutics. | 2020-06-19 |
| 32513867 | These findings may help guide rational vaccine design and facilitate development and evaluation of effective therapeutics and vaccines against COVID-19 disease. | 2020-06-13 |
| 32513951 | Here, we update the recent understanding in clinical characteristics, diagnosis strategies, as well as clinical management of COVID-19 in China as compared to Italy, with the purpose to integrate the China experience with the global efforts to outline references for prevention, basic research, treatment as well as final control of the disease. […] Being the first two countries we feel appropriate to evaluate the evolution of the disease as well as the early result of the treatment, in order to offer a different baseline to other countries. | 2020-06-26 |
| 32514104 | The neuropeptide oxytocin has attracted great attention of the general public, basic neuroscience researchers, psychologists, and psychiatrists due to its profound pro-social, anxiolytic, and “anti-stress” behavioral and physiological effects, and its potential application for treatment of mental diseases associated with altered socio-emotional competence. | 2020-06-27 |
| 32514228 | Due to the absence of effective treatment or vaccines against COVID-19 so far, the precautionary measures according to WHO’s strategic objectives are the only way to confront this crisis. | 2020-06-11 |
| 32514230 | Community-based involvement is crucial to ensure continuity of care and treatment for PLWH. | 2020-06-11 |
| 32514287 | An effective, safe and proven treatment has not yet been found. […] Chloroquine has been recommended by some authors to be used for the treatment of patients infected with this virus however chloroquine may have side effects and drug resistance problems. […] Artesunate was thought to be an effective treatment for covid-19 because of its anti-inflammatory activity, NF-κB (nuclear Factor kappa B)-coronavirus effect and chloroquine-like endocytosis inhibition mechanism. | 2020-06-11 |
| 32514320 | Rapid assessment of the cardiorespiratory function to monitor disease progression and guide treatment is essential. | 2020-06-11 |
| 32514354 | We report a case series of seven mechanically ventilated patients with acute respiratory distress syndrome (ARDS) caused by coronavirus disease (COVID-19) who received early treatment with high-dose, short-term systemic corticosteroids to prevent cytokine overproduction. […] This high-dose, short-term corticosteroid therapy enabled extubation of the patients within seven days. […] Many questions on the clinical management of COVID-19 remain unanswered, and data on corticosteroid therapy as a choice of treatment are mixed. | 2020-06-19 |
| 32514399 | This report describes a case of Bacillus cereus bacteremia in a COVID-19 patient with prior inhalational steroid use and inpatient steroid treatment for COVID-19 pulmonary symptoms. | 2020-06-11 |
| 32514431 | As inflammatory bowel disease (IBD) is a chronic disease, and most patients are on long-term immunosuppressive agents, there is understandable concern, particularly in terms of therapy. | 2020-06-11 |
| 32514587 | Oncocardiology aims to detect and treat cardiovascular diseases associated with cancer and cancer therapy. […] This review summarizes current developments in the field of oncocardiology with regard to advances in cancer therapy and challenges in clinical oncocardiology work. | 2020-06-12 |
| 32514598 | The purpose of this rapid guideline is to provide recommendations on the organizational management of intensive care units caring for patients with COVID-19 including: planning a crisis surge response; crisis surge response strategies; triage, supporting families, and staff. | 2020-06-12 |
| 32514620 | For aSAH, the number of cases, aSAH grade, aneurysm localization, and treatment modality did not change but strikingly, elderly patients with cSDH presented less frequently, with more severe symptoms (p = 0.046), and were less likely to reach favorable outcome (p = 0.003) at discharge compared with previous years. | 2020-06-12 |
| 32514674 | Therefore, the challenge in everyday life will be to achieve in due time the differential diagnosis as well as the long-term psychological impact.Key Points• SSc patients should be encouraged to continue their chronic therapy; in case of immunosuppressive therapy it must be discontinued for safety in case of COVID-19 infection. | 2020-06-24 |
| 32514682 | Patients on anticoagulant treatment are constantly increasing, with an estimated prevalence in Italy of 2% of the total population. | 2020-06-12 |
| 32514854 | A case with rheumatoid arthritis and insufficient compensation under disease-modifying combined long-term therapy with methotrexate and leflunomide is reported. […] After recovery from a COVID-19 infection, a tumor necrosis factor (TNF) inhibitor therapy was initiated. | 2020-06-12 |
| 32514935 | Angiotensin-converting enzyme (ACE) inhibitors (ACEIs) and angiotensin II type‑1 receptor blockers (ARBs) are among the most widely prescribed drugs for the treatment of arterial hypertension, heart failure and chronic kidney disease. | 2020-06-12 |
| 32515033 | The immune system of cancer patient gets compromised because of cancer therapy, surgery and malignancy and thus the probability of infection are increased than the general patients. | 2020-06-19 |
| 32515039 | Hospital resources have been compromised, especially in intensive care units (ICUs). […] Regarding that, some nephrologists have alerted about the potential shortages of our ability to deliver kidney replacement therapy to all patients who need it (1). | 2020-06-19 |
| 32515084 | The advice is based on psychobiological principles of sleep regulation and on guidelines for the treatment of insomnia and was implemented within an initiative offering psychological support to the staff of three university hospitals in Rome. | 2020-06-19 |
| 32515125 | Female sex, steroid treatment, and using the local newspaper as a primary source of information were independently associated with expressed fear of infection in SOT recipients. | 2020-06-27 |
| 32515168 | Our hypothesis can be tested in COVID-19-infected patients and eventually lead to new approaches to risk stratification and therapy. | 2020-06-19 |
| 32515253 | Common unintended non-therapeutic target effects of COVID-19 treatment include IKr blockade, CYP450 isoenzyme inhibition or activation, and P-glycoprotein inhibition. | 2020-06-09 |
| 32515332 | After a few days of treatment, the patient was discharged in stable condition for isolation at home. […] The patient had previously had contact with the mental health services and was diagnosed with catatonic schizophrenia but had been without outpatient contact or treatment for the last four years. | 2020-06-15 |
| 32515370 | As of now, there is no confirmed treatment or vaccine against COVID-19. | 2020-06-18 |
| 32515372 | Resource husbandry, which refers to the judicious use of available stocks, is a vital concept that needs to be promoted during such challenging times to combat the shortage of medical resources while simultaneously providing effective treatment to the patients. | 2020-06-18 |
| 32515380 | Currently, if these subjects are infected with SARS-CoV-2, they must not stop their treatment. | 2020-06-18 |
| 32515382 | Cardiac dysfunction has been identified as a risk factor, a prognostic factor, a diagnostic tool, differential diagnosis, a complication of COVID 19, and a side effect of its treatment. | 2020-06-18 |
| 32515383 | Novel coronavirus disease (COVID-19) infection is a global pandemic, of high infectivity, variable mortality, with currently no established treatment. […] This review summarizes different molecules which are being evaluated for COVID19 treatment. […] PubMed and Medline, search for articles published to March 2020 was done using terms “COVID19” OR “corona-virus 2019” OR “2019-nCoV” or “severe acute respiratory syndrome coronavirus” AND “treatment”. […] COVID19 treatment agents can be broadly classified into immuno-modulators (prevent hyperimmune-activation and cytokine storm) and anti-viral therapies (prevent virus entry, replication or viricidal). […] It may be concluded that the most successful regimen is going to be multi-drug therapy, a combination of immunomodulatory agent with anti-viral agent. | 2020-06-18 |
| 32515386 | We put a spotlight on investigational new drugs for treatment of COVID medications and virtual care. | 2020-06-18 |
| 32515389 | Standardised guidelines from initial studies are now available for diagnosis, treatment, and prevention. […] Treatment is mostly supportive with no recommendations for any specific drugs so far. | 2020-06-18 |
| 32515391 | Guidelines for the delivery of emergency dental treatment are formulated based on different guidelines from various international dental associations and organisations. | 2020-06-18 |
| 32515395 | Its treatment and management require huge efforts from medical professionals often at the cost of their own health and life. […] Nutrition is the epicenter for the management of such diseases which works synergistically with the medical treatment for quick and better recovery. […] Medical nutritional therapy is thus among the mainstay of core components of comprehensive treatment measures for patients with COVID-19. | 2020-06-18 |
| 32515397 | Currently, there is no definitive treatment or vaccine for COVID-19. | 2020-06-18 |
| 32515500 | Clinical history, comorbidities, laboratory findings and treatment were recorded for each patient. | 2020-06-19 |
| 32515570 | The coronavirus disease 2019 (COVID-19) pandemic affects anticoagulation not only in those infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) but also in most patients who require daily anticoagulant therapy and are facing substantial limitations in medical care these days. […] Concomitant venous thromboembolism (VTE), a potential cause of unexplained deaths, has frequently been reported in patients with COVID-19, but its management is still challenging due to the complexity between antithrombotic therapy and hematological alterations. […] In the era of COVID-19 pandemic, it is highly recommended for patients who require chronic anticoagulation to continue therapy to prevent thromboembolic events. […] In patients with COVID-19 who are suspected of VTE or in whom the diagnosis is confirmed, parenteral therapy with low-molecular-weight heparin should be initiated in the absence of contraindications. […] In case of confirmed acute pulmonary embolism, treatment should be guided by risk stratification as defined in the current guidelines. | 2020-06-26 |
| 32515676 | All patients recovered after intravenous immunoglobulin therapy. | 2020-06-16 |
| 32515698 | Information about the epidemiology, etiology, pathogenesis, clinical and laboratory diagnostics, as well as prevention and therapy for this disease is constantly being expanded and reviewed. | 2020-06-17 |
| 32515699 | The article discusses pathogenesis and treatment of COVID-19. | 2020-06-17 |
| 32515982 | There is currently no vaccine available and also no effective drug for the treatment of COVID-19. […] Preclinical studies and clinical trials with slow-releasing H2S donor(s) or the activators of endogenous H2S-generating enzymes should be considered as a preventative treatment or therapy for COVID-19. | 2020-06-09 |
| 32516107 | The patient’s felt relieved immediately after the procedure; however, the oxygen saturation did not raise above 85% despite the oxygen therapy. […] Thus, the treatment for COVID-19 was immediately initiated. | 2020-06-09 |
| 32516119 | Patients with inflammatory bowel disease are more susceptible to severe viral infections requiring hospitalization regardless of treatment. […] Immunosuppressives and biological treatments multiply the chances of opportunistic and lung infections, especially in combination therapy, so due to the new coronavirus (severe acute respiratory syndrome coronavirus-2) epidemic, which primarily causes respiratory disease, it is advisable to use different therapeutic considerations for effective and safe patient care. […] However, it should not be forgotten that the patients on immunosuppressive and/or biological therapy belong to the compromised group. […] Consequently, in some cases there is a need to modify the therapy, but we should keep in mind that the relapse alongside with the need of medical consultation and even hospitalization elevate the chance of being infected. […] Thus, flare-ups ought to be avoided as far as they can be, so continuing the already started maintenance therapy can be a reasonable solution, but, in the high-risk group, modifying it can be reasonable as well. | 2020-06-11 |
| 32516124 | Following 6 weeks of therapeutic dose low-molecular-weight heparin (LMWH) treatment, the cancerous colonic section was resected. […] Post-operatively she became pyrexial and COVID-19 was confirmed, but later became apyrexial with symptomatic treatment. […] It is worthy of note that due to the active anastomosis bleed the angiotensin-converting enzyme (ACE)-inhibitor treatment was stopped, and later the patient got infected with SARS-CoV-2. […] A long-lasting LMWH therapy was performed. […] The appropriate treatment of these patients during the pandemic presents a great challenge for all doctors, but, as shown in our case report, surgical treatment of even those with multiple co-morbidities can be successful. | 2020-06-11 |
| 32516161 | We recorded the number of patients managed, of patients transferred to emergency departments (ED), and of mobile intensive care units (MICUs) dispatched. | 2020-06-09 |
| 32516421 | World health systems are organizing to respond to the pandemic by implementing acute intensive care and sub-intensive care units. | 2020-06-09 |
| 32516429 | COVID-19 is a highly prothrombotic disease, frequently requiring anticoagulation for prevention or treatment of thrombosis and to enable organ support (Bikdeli, Madhavan et al. | 2020-06-19 |
| 32516482 | The case is a splendid example of the implementation of TM and good collaboration between a Comprehensive Hemophilia Treatment Center (CHTC) and a local hospital. | 2020-06-19 |
| 32516506 | However, remaining a bridging strategy, extracorporeal life support cannot act as the ultimate treatment of the underlying COVID-19 disease. […] Further, we believe, that research should be facilitated and promoted, particularly under the guidance of recognized scientific societies or expert-based multicenter investigation, with rapid communication of critical and relevant information to enhance better appraisal of patient profiles, complications, and treatment modalities. | 2020-06-19 |
| 32516571 | Our results show that the hACE2 mouse would be a valuable tool for testing potential vaccines and therapeutics. | 2020-06-25 |
| 32516658 | The authors aimed to introduce an appropriate treatment protocol for oropharyngeal bleeding that provides first aid to patients while protecting medical staff at high-risk of infection such as COVID-19. | 2020-06-28 |
| 32516704 | Patients with haematological cancer and those who are receiving active chemotherapy treatment may be at greatest risk due to increased immunosuppression. […] In this review we will discuss the impact of COVID-19 on patients affected by cancer, their diagnosis and management, as well as the pathophysiology of COVID-19 induced acute respiratory distress symptoms and currently investigated treatment approaches. | 2020-06-19 |
| 32516766 | We propose nurse-led and allied health-led ACP discussions to ensure patient and family inclusion and understanding of the disease prognosis, prevention of overtreatment, and potential outcomes in crisis times. | 2020-06-09 |
| 32516795 | However, for the moment, it is crucial that asthmatic patients maintain their controller medication, from inhaled corticosteroids to biologics, without making any dose adjustments on their own or stopping the medication. | 2020-06-09 |
| 32516797 | Effective therapeutics to treat COVID-19 are urgently needed. […] In animal models, remdesivir treatment was effective against MERS-CoV and SARS-CoV infection.2,5,6 In vitro, remdesivir inhibited replication of SARS-CoV-2.7,8 Here, we investigated the efficacy of remdesivir treatment in a rhesus macaque model of SARS-CoV-2 infection9. […] In contrast to vehicle-treated animals, animals treated with remdesivir did not show signs of respiratory disease and had reduced pulmonary infiltrates on radiographs and reduced virus titers in bronchoalveolar lavages 12hrs after the first treatment administration. […] Virus shedding from the upper respiratory tract was not reduced by remdesivir treatment. […] Thus, therapeutic remdesivir treatment initiated early during infection had a clinical benefit in SARS-CoV-2-infected rhesus macaques. […] Although the rhesus macaque model does not represent the severe disease observed in a proportion of COVID-19 patients, our data support early remdesivir treatment initiation in COVID-19 patients to prevent progression to pneumonia. | 2020-06-09 |
| 32516839 | In the absence of a vaccine or specific drug treatment options for coronavirus disease (COVID-19), attention has been shifted in China to the possible therapeutic use of convalescent plasma. […] We summarized clinical studies and other research data available as of May 5, 2020, on CCP therapy according to the Clinical Treatment Guideline of COVID-19 Convalescent Plasma in China, as well as clinical experience at the First Affiliated Hospital of Zhejiang University, as part of a comprehensive anti-epidemic strategy. […] From initial studies, convalescent plasma therapy appears effective and safe for COVID-19. | 2020-06-19 |
| 32516853 | One example is the creation of the CTAP (Coronavirus Treatment Acceleration Program) by the FDA (U.S Foods And Drugs Administration) to support clinical trials. | 2020-06-19 |
| 32517166 | COVID-19-associated pulmonary aspergillosis (CAPA) is a recently described disease entity affecting patients with severe pulmonary abnormalities treated in intensive care units. […] Delays in diagnosis contribute to a delayed start of antifungal therapy. […] We present a patient with putative CAPA due to Aspergillus fumigatus with identification of a triazole-resistant isolate during therapy. | 2020-06-11 |
| 32517786 | Hydroxychloroquine and chloroquine, also known as antimalarial drugs, are widely used in the treatment of rheumatic diseases and have recently become the focus of attention because of the ongoing COVID-19 pandemic. […] We also discuss possible adverse effects, adding a practical and comprehensive approach to monitoring rheumatic patients during treatment with these drugs. | 2020-06-24 |
| 32517803 | In this descriptive study, we detail Twitter activity regarding spinal manipulative therapy (SMT) and claims it increases, or “boosts”, immunity. | 2020-06-18 |
| 32517822 | A close look at how long COVID-19 patients stayed in the hospital could provide an overview of their treatment process in Vietnam, and support the country’s National Steering Committee on COVID-19 Prevention and Control in the efficient allocation of resources over the next stages of the COVID-19 prevention period. | 2020-06-25 |
| 32517998 | Due to the absence of treatment and vaccine against these emerging pathogens, the relation between these beliefs and these behaviors represents a crucial issue for public health policies. | 2020-06-12 |
| 32518045 | Supportive treatments were invasive mechanical ventilation (n=9), catecholamine (n=4), erythropheresis (n=4), renal replacement therapy (n=1), and extracorporeal membrane oxygenation (n=1). | 2020-06-17 |
| 32518172 | Concerns for modifications-if any-of chronic immunotherapies with steroids, mycophenolate, azathioprine, IVIg, and anti-B-cell agents were addressed; the role of complement in innate immunity to viral responses and anti-complement therapeutics (i.e. eculizumab) were reviewed. […] Emerging data indicate that COVID-19 can trigger not only GBS but other autoimmune neurological diseases necessitating vigilance for early diagnosis and therapy initiation. | 2020-06-25 |
| 32518212 | Cross-sectional analysis of clinical trials for the treatment of COVID-19 that were registered in the USA or in countries contributing to the WHO’s International Clinical Trials Registry Platform. […] In 152 trials (75.7%), patients were randomised to treatment or comparator, including 55 trials with some form of blinding and 97 open-label studies. | 2020-06-23 |
| 32518317 | As of today, there is no antiviral for the treatment of the SARS-CoV-2 infection, and the development of a vaccine might take several months or even years. | 2020-06-26 |
| 32518419 | Rux treatment for COVID-19 in patients with hyperinflammation is shown to be safe with signals of efficacy in this pilot case series for CRS-intervention to prevent or overcome multiorgan failure. | 2020-06-13 |
| 32518555 | The TCM theoretical system of treating epidemic diseases with TCM and the treatment scheme of integrated Chinese and Western medicine have proved their effectiveness in clinical practice. | 2020-06-12 |
| 32518636 | On April 28, 2020, a total of 945 studies on COVID-19 have been registered in ClinicalTrials.gov; 586 studies are interventional (62.0%), the most frequent allocation scheme is the parallel group assignment (437; 74.6%), they are open-label and the most common primary purpose is the research on treatment. | 2020-06-17 |
| 32519117 | Currently, there are no treatment recommendations for conjunctivitis associated with COVID-19. […] Tear substitutes might be helpful for symptom relief but there is no evidence for a topical antiviral therapy. […] In the future ophthalmologists could play a decisive role in the screening of maculopathies that might occur during COVID-19 treatment using chloroquine or hydroxychloroquine. | 2020-06-12 |
| 32519281 | Hydroxychloroquine has been promoted for its use in treatment of COVID-19 patients based on in-vitro evidences. | 2020-06-13 |
| 32519302 | Mesenchymal stem cell (MSC)-based therapy may be an potential alternative strategy for treating ARDS by targeting the various pathophysiological events of ARDS. […] An increasing number of experimental animal studies and early clinical studies verify the safety and efficacy of MSC therapy in ARDS. […] Here, we provide a comprehensive review of the mechanisms and optimization of MSC therapy in ARDS and highlighted the potentials and possible barriers of MSC therapy for COVID-19 patients with ARDS. | 2020-06-13 |
| 32519568 | The Covid-19 pandemic caused a marked increase in admissions to intensive care units. | 2020-06-10 |
| 32519617 | We retrospectively evaluated demographic characteristics, currently used immunosuppressant treatment, present complaints, treatment and diagnosis of comorbid diseases, and results of COVID-19 tests. […] He received treatment with hydroxychloroquine (400 mg/day). | 2020-06-24 |
| 32519618 | Among these, we retrospectively evaluated 602 patients (257 female/345 male) with chronic renal failure receiving hemodialysis as renal replacement therapy; 7 patients (1.1%) were infected with SARS-CoV-2. | 2020-06-24 |
| 32519768 | Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a global health emergency, in which its effective treatment and prevention remain obscured. […] Understanding the association between hyperpyrexia and SARS-CoV-2 will help to elucidate the COVID-19 pathogenesis, which is mandatory for developing effective treatment strategies. | 2020-06-19 |
| 32519786 | Our patients were treated by oxygen via face mask in one case and mechanical ventilation as supportive treatment in the other patient. […] Treatment is based on a good oxygenation, intravenous corticosteroids, diuretics, Azithromycine, vitamin C, and other symptomatic treatments. | 2020-06-19 |
| 32519827 | One-third of the subjects were not aware regarding Personal Protective Equipment (PPE) to be used while rendering dental treatment. 75% of subjects were of the opinion that supportive care is the current treatment regime for COVID-19. | 2020-06-22 |
| 32519842 | The COVID-19 outbreak has fueled a global demand for effective diagnosis and treatment as well as mitigation of the spread of infection, all through large-scale approaches such as specific alternative antiviral methods and classical disinfection protocols. | 2020-06-26 |
| 32519894 | Due to this lack of data-driven treatment strategies, broad variations in practice patterns have emerged. […] We seek to provide an overview of the data supporting the therapeutic use of heparin, both unfractionated and low molecular weight, as an anticoagulant for the treatment of SARS-CoV-2 infection. […] Finally, we discuss known adverse effects and theoretical off-target effects that may temper enthusiasm for the adoption of heparin as a therapy in COVID-19 without confirmatory prospective randomized controlled trials. […] Despite previous failures of anticoagulants in critical illness, plausibility of heparin for COVID-19 is sufficiently robust to justify urgent randomized controlled trials to determine the safety and effectiveness of this therapy. | 2020-06-10 |
| 32519921 | There is no data on COVID-19 in patients with severe asthma or patients with asthma who are treated with monoclonal antibodies.Case Study: Here, we present the case of a severe eosinophilic asthmatic in whom benralizumab treatment, an anti-IL-5R monoclonal antibody, was initiated 2 years ago. […] Prior to benralizumab treatment, every viral infection had resulted in a prolonged course of oral corticosteroids (OCS). | 2020-06-19 |
| 32519978 | A literature review of PubMed, ResearchGate, ScienceDirect, the Cochrane Library, and TCM monographs was conducted and the effects of the plants on the cardiovascular system and the mechanisms of action in COVID-19 treatment were evaluated. […] The mechanism of action, cardiovascular effects, and possible toxicity of 10 plants frequently found in TCM formulations that were used in the clinical treatment of COVID-19 were examined. […] TCM formulations that had been originally developed for earlier viral diseases have been used in COVID-19 treatment. | 2020-06-24 |
| 32520031 | To date, no specific drug has been discovered for the treatment of COVID-19 and hence, people are in a state of anxiety. | 2020-06-25 |
| 32520071 | There is no randomized controlled clinical trial addressing potential therapies for patients with confirmed COVID-19 infection at the time of publishing these treatment recommendations. | 2020-06-15 |
| 32520076 | Approximately 81.08% of the parents expressed confidence after we informed them about the preventive measures taken in the dental department to ensure safe treatment for their children. | 2020-06-15 |
| 32520155 | The challenges of cancer treatment in the midst of COVID-19 global pandemic highlight the importance of a rapid response by institutions, where organizational structure, strategic planning, agility in guidelines implementation and alternative ways to protect and support clinical staff, employees and patients may be the key to mitigate pandemic effects. | 2020-06-15 |
| 32520160 | The present study aimed to review the epidemiology, clinical manifestation, laboratory diagnosis, treatment, and future perspectives related to COVID-19 infections. | 2020-06-15 |
| 32520223 | Pediatric gastroenterologists, family members, and caregivers of patients with inflammatory bowel disease (IBD) are on alert; they are all focused on implementing prophylactic measures to prevent infection by severe acute respiratory syndrome coronavirus 2, evaluating the risks in each patient, guiding them in their treatment, and keeping IBD in remission. | 2020-06-22 |
| 32520289 | This can potentially reduce adhesion to ongoing treatment resulting in avoidable recurrence of a disorder. | 2020-06-17 |
| 32520508 | However, early diagnosis may be challenging, especially in cancer patients under treatment with immunotherapy as drug-induced pneumonitis can present similar clinical and radiological features. […] We describe the findings of a SARS-CoV-2 infection on PET/CT with F-FDG in a 51-year-old man with metastatic renal cell carcinoma under treatment with nivolumab. | 2020-06-19 |
| 32520683 | Potential therapeutic drugs, vaccine and stem cell replacement methods are emerging, it is urgent to find specific therapeutic drugs and the best treatment regimens. […] After the publication of hydroxychloroquine (HCQ) with anti-SARS-COV-2 activity in vitro, a small, non-randomized, open-label clinical trial showed that HCQ treatment was significantly associated with reduced viral load in patients with coronavirus disease-19 (COVID-19). […] HCQ offered a promising efficacy in the treatment of COVID-19, but the optimal administration is still being explored. | 2020-06-10 |
| 32520743 | They all had higher grade surgeries but none required escalated or intensive care treatment related to COVID infection. | 2020-06-19 |
| 32520747 | These benefits include improved medication adherence, appointment adherence, reduced instances of relapse, and fewer re-hospitalizations. | 2020-06-10 |
| 32520770 | This review introduces current understanding of SARS-CoV-2 infection and treatment strategies, emphasizing the relevant challenges associated with prevention, diagnosis, and management. | 2020-06-10 |
| 32520888 | All 25 children with laboratory-confirmed 2019-nCoV infection by real-time reverse transcription-PCR (RNA-PCR) were admitted from the 4 designated treatment hospitals of 2019-nCoV in Chongqing from January 19 to March 12, 2020. […] There was no significant difference of RNA turning negative between the groups of interferon, interferon plus ribavirin and interferon plus lopinavir or ritonavir treatment. | 2020-06-26 |
| 32521039 | Alternative options for the treatment of patients with headache disorders and the use of telemedicine are also explored. […] Though headache care in the COVID-19 era requires alterations, the improved preventive treatment options now available and evidence for feasibility and safety of telemedicine well positions clinicians to take care of such patients, especially in the COVID-19 epicenter of New York City. | 2020-06-20 |
| 32521191 | One first proposed clinical trial has drawn worldwide hype to the benefit of chloroquine (CQ), in the treatment of patients infected by the recently emerged deadly coronavirus (SARS-CoV-2). | 2020-06-19 |
| 32521463 | We have performed an extensive literature search for articles in PubMed, EMBASE and Google Scholar databases till 25 May 2020, with the following keywords: “COVID-19”, “diabetes mellitus”, “thyroid disorders”, “primary adrenal insufficiency”, “Cushing’s syndrome”, “pituitary tumors”, “vitamin D″”, “osteoporosis”, “primary hyperparathyroidism”, “hypoparathyroidism”, “management”, “treatment” and “guidelines” with interposition of the Boolean operator “AND”. | 2020-06-26 |
| 32521580 | It was indicated in the diagnosis and treatment scheme, by the National Health Commission of the People’s Republic of China, that blood purifications such as plasma exchange, plasma adsorption, hemoperfusion, hemofiltration and plasmafiltration could be considered for use in the critical patients with cytokine storm syndrome. […] This expert consensus, proposed by the Chinese Society of Nephrology and the Nephrology Committee of Chinese Research Hospital Association, is to guide and standardize the clinical application of blood purifications in the treatment of severe or critical patients with COVID-19. | 2020-06-10 |
| 32521771 | The pharmacokinetic profile of mefloquine was investigated as a preliminary study towards a potential treatment for feline coronavirus infections (such as feline infectious peritonitis) or feline calicivirus infections. […] Mefloquine may provide a safe effective treatment for feline coronavirus and feline calicivirus infections in cats. | 2020-06-11 |
| 32521953 | The treatment strategy for the elderly patients has its own characteristics and treatment protocol should be considered accordingly. […] To improve the diagnosis, treatment, and prevention of COVID-19 in the elderly, the Expert Committee of Geriatric Respiratory and Critical Care Medicine, China Society of Geriatrics established the “Expert consensus for the diagnosis, treatment, and prevention of Coronavirus disease 2019 in the elderly” . […] We focused on the clinical characteristics and key points for better treatment and prevention of COVID-19 in the elderly. […] (2) For treatment, strategy of multiple disciplinary team (mainly the respiratory and critical care medicine) should be adopted and multiple systemic functions should be considered. | 2020-06-11 |
| 32522037 | We reviewed the literature of patients coinfected with both viruses and discussed the characteristics, as well as treatment options. | 2020-06-22 |
| 32522067 | In this short perspective, we discuss the roles of CQ/HCQ in the treatment of COVID-19 patients and propose new ways of possible treatment for SARS-CoV-2 infection based on the molecules that selectivity target autophagy.Abbreviation: ACE2: angiotensin I converting enzyme 2; CoV: coronavirus; CQ: chloroquine; ER: endoplasmic reticulum; HCQ: hydroxychloroquine; MERS-CoV: Middle East respiratory syndrome coronavirus; SARS-CoV: severe acute respiratory syndrome coronavirus; SARS-CoV-2: severe acute respiratory syndrome coronavirus 2. | 2020-06-24 |
| 32522207 | A better understanding of the pathophysiology associated with COVID-19 is crucial to improve treatment modalities and to develop effective prevention strategies. | 2020-06-23 |
| 32522223 | If we focus our attention on seven main features of COVID-19 infection (heterogeneity, fragility, lack of effective treatments and vaccines, “miraculous cures”, psychological suffering, deprivation, and globalization), we may establish parallelism with the challenges faced in the steep road to the understanding and treatment of neoplastic diseases. | 2020-06-22 |
| 32522282 | The aim of this randomised GCP-controlled trial is to clarify whether combination therapy with the antibiotic azithromycin and hydroxychloroquine via anti-inflammation/immune modulation, antiviral efficacy and pre-emptive treatment of supra-infections can shorten hospitalisation duration for patients with COVID-19 (measured as “days alive and out of hospital” as the primary outcome), reduce the risk of non- invasive ventilation, treatment in the intensive care unit and death. […] • Myasthenia gravis • Treatment with digoxin* • Glucose-6-phosphate dehydrogenase deficiency • Porphyria • Hypoglycaemia (Blood glucose at any time since hospitalization of <3.0 mmol/L) • Severe mental illness which significantly impedes cooperation • Severe linguistic problems that significantly hinder cooperation • Treatment with ergot alkaloids *The patient must not be treated with digoxin for the duration of the intervention. […] For atrial fibrillation/flutter, select according to the Cardiovascular National Treatment Guide (NBV): Calcium antagonist, Beta blocker, direct current (DC) conversion or amiodarone. […] In case of urgent need for digoxin treatment (contraindication for the aforementioned equal alternatives), the test drug should be paused, and ECG should be taken daily. […] Control group: The control group will receive the standard treatment + placebo for both types of intervention medication at all times. […] If part or all the intervention therapy being investigated becomes standard treatment during the study, this may also be offered to the control group. […] Immediately after randomisation to the intervention group, the patient will begin treatment with: Azithromycin: Day 1-3: 500 mg x 1 Day 4-15: 250 mg x 1 If the patient is unable to take the medication orally by themselves, the medication will, if possible, be administered by either stomach-feeding tube, or alternatively, temporary be changed to clarithromycin 500 mg x 2 (this only in agreement with either study coordinator Pradeesh Sivapalan or principal investigator Jens-Ulrik Stæhr Jensen). | 2020-06-17 |
| 32522307 | In this article, we explain the symptoms and course of the disease and the treatment for an adult patient with CHD who has been infected with novel nCoV-19. | 2020-06-25 |
| 32522513 | Social distancing requirements may place patients at higher risk for intimate partner violence and mental health concerns; threaten continued access to contraception and abortion services; impact prepregnancy planning; interrupt routine screening for breast and cervical cancer; increase risk of sexually-transmitted infection acquisition and decrease access to treatment; and exacerbate already underlying racial and minority disparities in care and health outcomes. […] Reproductive healthcare access can be ensured through reducing needs for ultrasound and laboratory testing for certain eligible patients desiring abortion and conducting phone follow-up for medication abortions. […] Priority for in-person appointments should be given to patients with sexually-transmitted infection symptoms, particularly if at risk for complications, while also offering expedited partner therapy. | 2020-06-11 |
| 32522574 | This epidemiological finding raises the question of whether physiological mechanisms underlying the acclimatization to high altitude identifies therapeutic targets for the effective treatment of severe acute respiratory syndrome pivotal to the reduction of global mortality during the COVID-19 pandemic. […] Finally, since erythropoietin (EPO) is an effective prophylactic treatment for AMS, this article reviews the potential benefits of implementing FDA-approved erythropoietin-based (EPO) drug therapies to counteract a variety of acute respiratory and non-respiratory (e.g. excessive inflammation of vascular beds) symptoms of SARS-CoV-2 infection. | 2020-06-21 |
| 32522597 | Coronavirus 2019 (COVID-19) is a pandemic with substantial mortality and no accepted therapy. […] All four patients experienced significant improvement in objective and symptomatic disease measures after one day of high dose therapy suggesting that zinc therapy was playing a role in clinical recovery. […] The limited sample size and study design preclude a definitive statement about the effectiveness of zinc as a treatment for COVID-19 but suggest the variables to be addressed to confirm these initial findings in future trials. | 2020-06-11 |
| 32522617 | Currently, there is no effective, proven treatment or vaccination for COVID-19, but many investigators are struggling to find a treatment strategy as soon as possible. […] Some potential medications like chloroquine by itself or in combination with azithromycin, and some protease inhibitors used for the treatment of COVID-19 have cardiovascular adverse effects that should be kept in mind in order to close monitor of the patients receiving these medications. | 2020-06-13 |
| 32522674 | Several improvements have been made, including discovery of the clinical efficacy of chloroquine (CQ) in patients with COVID-19, but effective treatment protocols remain elusive. […] In the search for novel treatment options, many scientists have used the in-silico approach to identify compounds that could interfere with the key molecules involved in entrance, replication or dissemination of severe acute respiratory syndrome coronavirus-2. […] As some of these drugs have probably been used empirically in the treatment of COVID-19, it is hoped that colleagues worldwide will publish patient data to enable evaluation of the potential efficacy of these agents in the clinical context, and rapid implementation in therapeutic protocols if they are shown to have a beneficial effect on clinical outcome. | 2020-06-22 |
| 32522737 | These study participants worked 4-6 hour shifts for an average of 5.4 days a week; they worked an average of 16.2 hours each week in intensive care units. | 2020-06-19 |
| 32522754 | A rapid recovery of respiratory and general symptoms was observed after 1 week of treatment with lopinavir/ritonavir plus hydroxychloroquine and broad-spectrum antibiotics (piperacillin-tazobactam plus teicoplanin). | 2020-06-23 |
| 32522812 | The COVID-19 pandemic crisis has necessitated widespread adaptation of revised treatment regimens for both urgent and routine medical problems in patients with and without COVID-19. […] Should doctors share information about unavailable but standard treatment alternatives when seeking consent? | 2020-06-24 |
| 32522813 | Key ethical challenges for healthcare workers arising from the COVID-19 pandemic are identified: isolation and social distancing, duty of care and fair access to treatment. […] Priority setting and access to treatment raise ethical issues of utility and equity. […] Difficult ethical dilemmas around triage, do not resuscitate decisions, and withholding and withdrawing treatment are discussed in the light of recently published guidelines. | 2020-06-27 |
| 32522846 | Because of these protective effects of ACE2 on ARDS, the development of drugs enhancing ACE2 activity may become one of the most promising approaches for the treatment of COVID-19 in the near future. | 2020-06-25 |
| 32523135 | The communications accumulated in the last weeks make it clear that there is no agreement to define the best treatment strategy in patients with acute coronary syndrome (SICA). […] In SICAs without ST segment elevation (SICASESST) the recommendations are very similar, favoring medical treatment over percutaneous coronary intervention in this subgroup of patients1. | 2020-06-23 |
| 32523136 | Reperfusion therapy is a measure of care in patients with ST-elevation myocardial infarction (STEMI), which should be performed once we have the diagnosis. […] Percutaneous coronary intervention is considered the gold standard, however in patients with SARS-CoV-2 infection, the reperfusion strategy is more focused on fibrinolytic therapy due to the shorter time required to perform and less exposure. | 2020-06-23 |
| 32523137 | There is no specific treatment or vaccine yet, so it is important to have hygiene, social isolation and personal protection measures. | 2020-06-23 |
| 32523141 | In this review article we have focused on four specific points: 1) epidemiology of the prevalence and mortality of COVID 19 in the general population and in the population with type 2 diabetes mellitus; 2) pathophysiology related to the binding of SARS-CoV-2 to receptors in subjects with diabetes; 3) the immune response induced by SARS-CoV-2, and 4) the outpatient and hospital treatment recommended in patients with diabetes who become infected with SARS-CoV-2. | 2020-06-23 |
| 32523142 | Given this need, some proposals have emerged to be able to diagnose, monitor and respond to the treatment of patients with COVID-19, such as pulmonary ultrasound (USP). | 2020-06-23 |
| 32523145 | The response of practically all Scientific Societies was almost immediate, with the precise indication that treatment with these drugs should not be discontinued, since the evidence of their usefulness is based on very solid and high-quality evidence. […] Simultaneously, a different hypothesis also appeared, also based on very preliminary evidence, that these drugs are not only harmful but also beneficial, however these medicaments are not yet accepted as agents for the prevention or treatment of this disease or its complications. | 2020-06-23 |
| 32523150 | The pandemic caused by the SARS-COV-2 or COVID-19 virus has been a global challenge given its high rate of transmission and lack of effective therapy or vaccine. […] The use of chloroquine/hydroxychloroquine, azithromycin and antiviral treatment and has been proposed by various groups, supported by in-vitro studies and limited patient series, without the adequate scientific rigor that precedes drug prescription. | 2020-06-23 |
| 32523151 | Finally, a review of the pharmacological recommendations on both oral and parenteral treatment in the outpatient, in hospitalization and in critical states infected with SARS-CoV-2 is made. | 2020-06-23 |
| 32523258 | Access to diagnostic tests, treatment facilities with the need to use clinical and prediction tools to guide management Telemedicine has an evolving role. […] A clinical decision along with use of clinical prediction tools for osteoporosis should be used to direct treatment. | 2020-06-12 |
| 32523681 | In this descriptive study, we detail Twitter activity regarding spinal manipulative therapy (SMT) and claims it increases, or “boosts”, immunity. | 2020-06-23 |
| 32523686 | Medication supplement is important for pulmonary hypertension patients when their heart function is well maintained. | 2020-06-12 |
| 32523870 | We provide important information regarding our clinical experience for further understanding of management discrepancies, as treatment with extracorporeal membrane oxygenation or pharmacotherapy (e.g., antivirals, immunomodulators, and glucocorticoids) is often dependent on the severity of symptoms. | 2020-06-12 |
| 32523920 | SARS-CoV-2 is a novel infectious agent that causes COVID-19, which can manifest in several ways, affecting endothelial cells and most organs.There is growing evidence that SARS-CoV-2-mediated endothelial damage is due to direct viral injury and the systemic inflammatory response, possibly together with a cytokine storm.As endothelial damage can manifest as thromboembolic disease, such as pulmonary thromboembolism, appropriate anti-thrombotic preventive strategies should be followed, and proper screening and treatment for thromboembolic complications should be implemented. | 2020-06-12 |
| 32523921 | We report a case of acute viral pericarditis and cardiac tamponade in a patient with COVID-19 to highlight the associated treatment challenges, especially given the uncertainty associated with the safety of standard treatment. […] Large pericardial effusion and cardiac tamponade should be considered in patients with COVID-19 who decompensate further after intubation and mechanical ventilation.The characteristics of pericardial effusion in patients with COVID-19 are described.A successful treatment approach for acute pericarditis in a patient with COVID-19 in light of differing opinions over the safety of NSAID use is described. | 2020-06-12 |
| 32523932 | The patient died despite appropriate treatment. […] The NIHSS score on admission of our patient meant anticoagulation therapy was not appropriate. | 2020-06-12 |
| 32523933 | Treatment for COVID-19 and empiric antibiotic therapy were promptly started. | 2020-06-12 |
| 32524147 | From the 594 patient questions analyzed, confirming diagnosis and seeking medical treatment account for 60.61% and 38.05%, respectively, followed by treating (25.59%), preventing (4.38%), and relieving anxiety (1.68%). | 2020-06-26 |
| 32524164 | The appropriate protective measures for orthopedic surgeons and patients were reviewed (on-site first aid, emergency room, operating room, isolation wards, general ward, etc.) during the entire diagnosis and treatment process of traumatic patients. […] Lessons learnt from our experience provide some recommendations of protective measures during the entire diagnosis and treatment process of traumatic patients and help others to manage orthopedic patients with COVID-19, to reduce the risk of cross-infection between patients and to protect healthcare workers during work. | 2020-06-13 |
| 32524227 | Hygienic measures and contact precautions, aimed at preventing the spread of MRDO, may have helped to prevent a SARS-CoV-2 transmission to HCW-despite high-risk exposure during intubation, surgical treatment and general care. | 2020-06-13 |
| 32524266 | However, the recent outbreak of coronavirus-associated disease-2019 (COVID-19) is placing an unprecedented strain on patients, physicians and world healthcare systems that resulted in deferral of elective and semi-elective procedures, such as SHD, and delay in the treatment of patients with acute coronary syndrome (ACS). | 2020-06-17 |
| 32524333 | These cases are characterized by extreme variability, from a mild or asymptomatic form lasting for a few days up to severe forms of interstitial pneumonia that may require ventilatory therapy and can lead to patient death.Several hypotheses have been drawn up to understand the role of the interaction between the infectious agent and the immune system in the development of the disease and the most severe forms; the role of the cytokine storm seems important.Innate immunity, as one of the first elements of guest interaction with different infectious agents, could play an important role in the development of the cytokine storm and be responsible for boosting more severe forms. […] Research on this topic is also needed to develop therapeutic strategies for treatment of this disease. | 2020-06-13 |
| 32524516 | After treatments, D-dimer levels decreased which was synchronous with hsCRP levels in patients with good clinical prognosis, but there were still some patients with anomalous increasing D-dimer levels after therapy. […] However, the abnormal changes of D-dimer and inflammatory factors suggest that anticoagulant therapy might be needed. | 2020-06-13 |
| 32524537 | As regards the treatment, it is advisable to use non-pharmacological interventions first where possible. […] Medication may be needed for patients with agitation where there is intractable distress or high risk to self/others. | 2020-06-13 |
| 32524646 | Despite numerous preliminary results, there is as yet no treatment of proven efficacy for this condition. […] In this context, the pharmacological properties of lithium, better known as a treatment for mood disorders, merit closer examination. […] These promising reports must be balanced against the narrow therapeutic index and high risk of toxicity associated with lithium therapy, its documented interactions with several commonly used drugs, and the absence of evidence of its efficacy against coronaviruses responsible for human disease. | 2020-06-24 |
| 32524708 | The current recommendations suggest that dental treatment of patients with suspected/confirmed coronavirus disease should be postponed for at least 14 days from the onset of symptoms (Peng et al., 2020). | 2020-06-23 |
| 32524712 | It is worth noting the complexity of the management of COVID-19 in two patients on prophylaxis with non-factor replacement therapy. […] Adherence to the prescribed treatment was maintained by 95.5% of patients. […] Their identification and treatment by a specialist team from a Haemophilia Treatment Center is essential to make a correct assessment of the risk of haemorrhage/thrombosis.COVID-19 had a major impact on the psychosocial aspects of these patients which must be remedied with recovery plans. | 2020-06-23 |
| 32524786 | CT quantitative parameters showed strong correlations with laboratory inflammatory markers, suggesting that CT quantitative analysis might be an effective and important method for assessing the severity of COVID-19, and may provide additional guidance for planning clinical treatment strategies. | 2020-06-19 |
| 32524843 | No targeted drugs have yet been available for intervention and treatment of this virus. | 2020-06-13 |
| 32524893 | Lockdown requires people to stay home and only leave when essential such as to purchase groceries and medication. | 2020-06-11 |
| 32524953 | We suggest that fecal matter from treatment facilities and recovered patients should be carefully and properly disposed. | 2020-06-11 |
| 32525005 | Pirfenidone (PFD), a pyridone compound, is well recognized as an antifibrotic agent tailored for the treatment of idiopathic pulmonary fibrosis. […] Recently, through its anti-inflammatory and anti-oxidant effects, PFD based clinical trial has also been launched for the treatment of coronavirus disease (COVID-19). | 2020-06-28 |
| 32525022 | Where uncertainty exists treatment should be informed by a dynamic risk assessment which may consider current COVID-19 prevalence, the person’s presentation (e.g. history of COVID-19 contact, COVID-19 symptoms), likelihood that treatment will be effective, availability of personal protective equipment (PPE) and personal risks for those providing treatment. | 2020-06-28 |
| 32525056 | In an effort to reduce potential exposure to aerosols generated during treatment, a device has been developed in which a polycarbonate shield is mounted to the dental operating microscope with an attached high velocity vacuum hose. | 2020-06-13 |
| 32525081 | The experiences of nurses who utilize telehealth in their care for children receiving end of life care in rural regions may enable palliative care teams to understand both the benefits and challenges of telehealth use. […] Nurse insights on telehealth may help palliative care teams better honor the communication needs of patients and families while striving to improve care access. | 2020-06-13 |
| 32525367 | This article (a) analyzes factors related to bereavement in the context of the COVID-19 pandemic; (b) proposes avenues for meaning-making practices to facilitate individual and collective mourning process; and (c) invites clinicians to pay attention to the traumatic characteristics of COVID-19-related deaths adopting a holistic approach of PGD clinical manifestations, as well as in evaluation and treatment of cases. | 2020-06-11 |
| 32525371 | The mental health consequences of the COVID-19 pandemic are particularly relevant in African-American communities because African-Americans have been disproportionately impacted by the disease, yet they are traditionally less engaged in mental health treatment compared with other racial groups. […] Using the state of Michigan as an example, we describe the social and psychological consequences of the pandemic on African-American communities in the United States, highlighting community members’ concerns about contracting the disease, fears of racial bias in testing and treatment, experiences of sustained grief and loss, and retraumatization of already-traumatized communities. | 2020-06-11 |
| 32525402 | Other factors that are also making this infection spread like a pandemic include global travelers, lack of proven treatment, asymptomatic carriers, potential reinfection, underprepared global health care systems, and lack of public awareness and efforts to prevent further spread. | 2020-06-22 |
| 32525548 | To investigate the prevalence, causes, and clinical implications of hypokalemia, including its possible association with treatment outcomes, among patients with COVID-19. […] The clinical features, therapy, and outcomes were compared between the 3 groups. […] The patients were given general support and antiviral therapy. […] The prevalence of hypokalemia and response to treatment with potassium supplements were measured by analyzing plasma and urine potassium levels. | 2020-06-17 |
| 32525568 | However, there is some cause for optimism, for example, in West Africa where infrastructure like diagnostic testing facilities, intensive care units, surveillance, and systems for reporting emergencies used during the EVD outbreak of 2013-2016 can be leveraged to fight the COVID-19 pandemic. | 2020-06-24 |
| 32525705 | Telehealth also enabled us to support patient-family communication, post-discharge follow-up, and palliative care for COVID-19 patients. | 2020-06-11 |
| 32525744 | However, in the setting of infection control policies, visitor restrictions, social distancing, and a lack of personal protective equipment, many of these important conversations are occurring by virtual visits. Objective: From our experience with a multisite study exploring the effectiveness of virtual palliative care, we have identified key elements of webside manner that are helpful when conducting serious illness conversations by virtual visit. Results: The key elements and components of webside manner skills are proper set up, acquainting the participant, maintaining conversation rhythm, responding to emotion, and closing the visit. | 2020-06-11 |
| 32525755 | It was concluded that telepsychiatry in the early stages of mental problems during a catastrophic event like the coronavirus pandemic, can be an efficient instrument for the screening of psychosomatic comorbidities, so that pharmacological treatment (considering possible drug interactions with COVID-19 medications) and psychotherapeutic intervention can be optimized by psychiatrists. | 2020-06-11 |
| 32525813 | Concerns arose regarding therapy with RAS inhibition during the COVID-19 pandemic. […] Unless large controlled studies are performed, RAS inhibition remains the cornerstone therapy in populations with cardiovascular disorders. | 2020-06-17 |
| 32525826 | At a time when the COVID-19 pandemic is approaching its peak, apart from the problems with treatment of the disease and care for critically ill patients, there are other equally important problems, such as organization of outbreak response, provision of health care, lack of hospital personnel, disruption of personal protective equipment supply chains and health care workers (HCWs) protection. | 2020-06-22 |
| 32525829 | We describe the clinical manifestations, disease progression, and treatment of wife and husband. | 2020-06-22 |
| 32525844 | Convalescent plasma is the only antibody based therapy currently available for COVID 19 patients. […] Although promising, convalescent plasma has not yet been shown to be safe as a treatment for COVID-19. | 2020-06-11 |
| 32525973 | The evaluation and treatment of thyrotoxicosis heavily relies on laboratory assessment and imaging with physical exam playing a role to help differentiate the etiology and assess the severity of thyrotoxicosis. | 2020-06-11 |
| 32526044 | To determine the acceptance rate of treatment alternatives for women with either preinvasive conditions or gynecologic cancers during the COVID-19 pandemic among Latin American gynecological cancer specialists. […] Respondents favored offering teleconsultation as triage for post-cancer treatment follow-up (94.6%), neoadjuvant chemotherapy in advanced stage epithelial ovarian cancer (95.6%), and total hysterectomy with bilateral salpingo-oophorectomy and defining adjuvant treatment with histopathological features in early stage endometrial cancer (85.4%). | 2020-06-11 |
| 32526046 |
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2020-06-23 |
| 32526068 | Patient concerns regarding risks conferred by their rheumatological disease or medications, impact of receiving the information sheet on the likelihood of staying on medication, and acceptance of telehealth, were ascertained. 2,630 patients received the message and the survey response rate was 21% (n=550). […] Proactive dissemination of information is needed to address misconceptions relating to medication risk, improve medication adherence and minimise the risk of flares. | 2020-06-19 |
| 32526079 | Since there are no effective preventive or curative therapies currently, MSC therapy (MSCT) has emerged as a possible candidate despite the lack of preclinical data of MSCs for COVID-19. | 2020-06-19 |
| 32526193 | Importantly, the presence of platelet-fibrin thrombi in small arterial vessels is consistent with coagulopathy, which appears to be common in patients with COVID-19 and should be one of the main targets of therapy. | 2020-06-13 |
| 32526208 | Nucleotide analog inhibitors, including broad-spectrum remdesivir and favipiravir, have shown promise in in vitro assays and some clinical studies for COVID-19 treatment, this despite an incomplete mechanistic understanding of the viral RNA-dependent RNA polymerase nsp12 drug interactions. | 2020-06-13 |
| 32526282 | Collectively, this work provides the basis for the future rational design of new antiviral therapeutics and vaccine development strategies targeting enveloped viruses. | 2020-06-17 |
| 32526365 | However, patients with tumor-like brain lesions requiring urgent surgery still received treatment as usual, in order to ensure ongoing neuro-oncological care. | 2020-06-26 |
| 32526698 | The emergence of several new NMOSD therapeutics, including immune-modulating agents, concurrently with the worldwide spread of the COVID-19 global pandemic call for careful therapeutic planning and add to the complexity of NMOSD management. […] Altering the common therapeutic approach to NMOSD during the pandemic may be necessary to balance both efficacy and safety of treatment. […] Selection of preventive therapy should take in consideration the viral exposure risk related to the route and frequency of administration and, most importantly, the immunological properties of each therapeutic agent and its potential impact on the risk of SARS-CoV-2 susceptibility and severity of infection. […] In this review, we will discuss the immune response against SARS-CoV-2 and evaluate the potential impact of the current and emerging NMOSD therapeutics on infection risk, infection severity, and future SARS-CoV-2 vaccination. | 2020-06-26 |
| 32526746 | It is a respiratory disease, and acute kidney injury (AKI) is rare; however, if a patient develops severe AKI, renal replacement therapy (RRT) should be considered. | 2020-06-11 |
| 32526774 | As most treatment modalities including antivirals and anti-inflammatory agents are mostly ineffective, an immunological approach is needed. […] As SARS-CoV-2 has many characteristics in common with two other viruses, SARS-CoV that cause severe acute respiratory syndrome (SARS) and MERS-CoV (Middle East respiratory syndrome coronavirus) that causes Middle East respiratory syndrome (MERS), the experiences learned from the use of passive immunity in treatment can be applied to COVID-19. | 2020-06-11 |
| 32527136 | The patient received antiviral therapy, antibacterial therapy, recombinant human interferon-α2a, vitamin C and oxygen inhalation. […] After two weeks of treatment and observation, the patient was clinical cured and discharged. | 2020-06-12 |
| 32527257 | To date, an ongoing experimental therapy with monoclonal antibody against the IL-6 receptor in Italy seems to have beneficial effects on severe lung disease and prognosis in patients with Covid-19 infection. | 2020-06-25 |
| 32527340 | To investigate the clinical treatment and assess the knowledge and use of the coronavirus disease 2019 (COVID-19) treatment plan issued by the nation. […] A nationwide questionnaire survey on line was administered to medical staffs involved in COVID-19 treatment on February 28th, 2020. […] The questionnaire included drug treatment, respiratory support therapy, sedation and analgesia, continuous renal replacement therapy (CRRT) and extracorporeal membrane oxygenation (ECMO), etc. […] There were 1 103 respondents, of whom 699 (504 doctors and 195 nurses) participated in the treatment of COVID-19. […] Considering that doctors dominated in the diagnosis and treatment of COVID-19, the results of the questionnaires of doctors were mainly analyzed. […] 55.4% of the doctors came from tertiary three hospitals, and most of them have senior titles (56.4%). 232 doctors (53.7%) participated in the treatment of mild COVID-19, and 200 doctors (46.3%) participated in the treatment of severe and critically ill patients. […] More than 95% of the doctors expressed that they would carry out antiviral treatment for patients with COVID-19 regardless of disease severity. […] The choice of antiviral drugs was highly consistent with the national treatment programs of COVID-19. […] 94.0% of doctors agreed to prescribe low-dose glucocorticoid therapy to severe and critically ill patients. […] About 2/3 of doctors would perform lung recruitment or prone position treatment for critical patients with invasive ventilation. […] Medical staffs are familiar with the national treatment plan of COVID-19 and willing to follow it. […] Further practical training is needed to make clinicians more aware of the disease, and more evidence-based evidence is needed to guide clinical treatment. | 2020-06-16 |
| 32527341 | Patients were divided into the normal type (set as normal group) and severe/critical type (set as severe group) according to the COVID-19 treatment plan classification standard published by National Health Commission of the People’s Republic of China. […] The establishment of early warning model could help to screen severe/critical patients at an early stage, with certain significance for guiding treatment. | 2020-06-16 |
| 32527343 | To investigate the clinical characteristics of gastrointestinal symptoms in patients with coronavirus disease 2019 (COVID-19) during the whole disease process, and provide reference for etiological diagnosis and treatment. […] The characteristics of gastrointestinal symptoms, such as poor appetite, nausea, vomiting and diarrhea were counted and analyzed, and the correlation between gastrointestinal symptoms and gender, age, basic diseases, disease severity, laboratory examination and drug treatment were analyzed. […] Whether it is caused by the virus or related drugs, diet and mental conditions, clinicians should analyze the causes of these symptoms timely, and then provide a better treatment for patients with COVID-19. | 2020-06-16 |
| 32527344 | To discuss the effective of artesunate in the treatment of coronavirus disease 2019 (COVID-19). […] Using prospective method, the 43 cases of confirmed COVID-19 patients in Nanning Fourth People’s Hospital from January 22nd to February 15th in 2020 were enrolled and divided into routine treatment group (n = 25) and artesunate treatment group (n = 18) by odd-even rule after admission. […] According to the guidelines, the routine treatment group was recommended to receive lopinavir/ritonavir 500 mg + α-aerosolized interferon 500×104 U, twice daily; the artesunate treatment group was given artesunate 60 mg, twice daily besides the routine treatment, for 10 days in both groups. […] During the treatment period, the pharynx swab test of 2019 novel coronavirus (2019-nCoV) nucleic acid was carried out every 2 days, and the routine blood test, liver and kidney functions, blood coagulation function and myocardial enzymes were re-examined. […] Chest CT was checked every 3 days after the treatment, and re-examined every 5 days after the condition was improved. […] There were no significant differences between the two groups in terms of gender, age, body weight, routine blood test and biochemical results before treatment. […] In artesunate treatment group, the time for significant improvement of symptoms (days: 3.33±1.91 vs. […] 18.04±3.97) were significantly shorter than those in routine treatment group, with significant differences (all P < 0.05). […] Artesunate can shorten the treatment time of COVID-19, improve prognosis and eliminate pathogens, with fewer adverse reactions and a good application prospect. | 2020-06-16 |
| 32527345 | However, at present, the treatment of patients has not been completed, and the effective treatment strategy and final prognosis are unclear. | 2020-06-16 |
| 32527346 | Sixty severe COVID-19 patients admitted to Changsha Public Health Treatment Center (North Hospital of the First Hospital of Changsha City) from January to March in 2020 were randomly divided into routine treatment group, Xuebijing 50 mL group and Xuebijing 100 mL group, with 20 cases in each group. […] The routine treatment group was treated according to the National Health Commission’s guide for COVID-19. […] On the basis of conventional treatment, Xuebijing injection was injected by 50 mL twice a day for 7 days in Xuebijing 50 mL group, while by 100 mL twice a day for 7 days in Xuebijing 100 mL group. […] The blood routine test, C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), acute physiology and chronic health evaluation II (APACHE II) score, 2019 novel coronavirus (2019-nCoV) nucleic acid test and disease classification of three groups before and 8 days after treatment were observed. […] (1) After treatment, the white blood cell count (WBC) and lymphocyte count (LYM) of three groups increased, meanwhile CRP and ESR decreased. […] Compared with routine treatment group, the WBC count of Xuebijing 100 mL group after treatment significantly increased (×109/L: 7.12±0.55 vs. […] (2) After treatment, the APACHE II score of three groups decreased. […] In Xuebijing 100 mL group, the APACHE II score after treatment was significantly lower than those in routine treatment and Xuebijing 50 mL groups (12.3±1.5 vs. […] After treatment, the 2019-nCoV nucleic acid test in three groups partly turned negative, with 9 cases in routine treatment group, 8 cases in Xuebijing 50 mL group and 9 cases in Xuebijing 100 mL group, without significant difference (P > 0.05). […] The conditions of patients in the three groups were improved after treatment, among them, 8 cases in the routine treatment group were transformed into common type, 1 case into critical type; 9 cases and 12 cases of Xuebijing 50 mL group and 100 mL group were transformed into common type respectively. […] Xuebijing 100 mL group was improved more obviously than Xuebijing 50 mL group and routine treatment group (both P < 0.05). | 2020-06-16 |
| 32527348 | To systematically review evidence for the effect of convalescent plasma and immunoglobulin on treatment of severe acute respiratory syndrome (SARS), and further provide advice on the treatment of coronavirus disease 2019 (COVID-19). […] Clinical studies of convalescent plasma and immunoglobulin in the treatment of SARS were collected from a variety of databases such as PubMed, Cochrane Library, Web of Science, Embase, CNKI, VIP, Wanfang, and CBM from November 2002 to March 2020. […] The systematic analysis showed that 107 patients administered convalescent plasma and 16 patients used immunoglobulin during the treatment of SARS. […] The treatment of convalescent plasma and immunoglobulin could both improve the symptoms and reduce the mortality (12 died), and most SARS patients got better, while 11 SARS patients who did not receive the above therapies died. | 2020-06-16 |
| 32527573 | Youth with HIV (YHIV) face many psychosocial and structural challenges resulting in poor clinical outcomes including lower rates of medication adherence and higher rates of uncontrolled HIV. […] We chronicle the structural and logistic approaches that our team has taken to proactively address the social determinants of health that will be negatively impacted by the COVID-19 pandemic, while supporting YHIV to maintain medication adherence and viral suppression. | 2020-06-12 |
| 32527675 | Whether patients with autoimmune rheumatic diseases (ARD) have a higher risk for SARS-CoV-2 infection (COVID-19) and how SARS-CoV-2 pandemic impacts on adherence to therapy has not been fully elucidated. […] We assessed the rate and clinical presentation of COVID-19, and adherence to therapy in a large cohort of patients with ARD followed-up in a tertiary University-Hospital in Northeast Italy. […] Demographics, disease activity status, therapy, occupational exposure, and adherence to social distancing advise were also collected. 916 patients (397 SLE, 182 AAV, 176 SSc, 111 RA, 50 IIM) completed the survey. 148 patients developed at least one symptom compatible with COVID-19 (cough 96, sore throat 64, fever 64, arthromyalgias 59, diarrhea 26, conjunctivitis 18, ageusia/hyposmia, 18). […] No deaths occurred. 31 patients (3.4%) withdrew ≥1 medication, mainly immunosuppressants or biologics. […] Adherence to therapy and to social distancing advise was high. | 2020-06-12 |
| 32527699 | Debate has been generated as to the association between antihypertensive therapy with renin-angiotensin-aldosterone system (RAAS) inhibitors and SARS-CoV-2 infection. | 2020-06-14 |
| 32527713 | Based on these, we proposed the new formulation called as “SNACK-V” CONCLUSION: Based on further experiments and clinical trials, these formulations could be used for effective treatment of COVID-19. | 2020-06-25 |
| 32527730 | Our patients were advised to maintain their scheduled appointments, and planned cancer treatment was continued without unnecessary delays in an outpatient setting. […] As of the data cut-off on 9 April 2020, a total of 156 oncology patients with a median age of 67 (range 26-86) years and 63 haematology patients (median age 69 years, range 23-89) were screened for COVID-19 during active cancer treatment. […] Our data indicate that continuation of anticancer treatment in epidemic areas during the COVID-19 pandemic seems to be safe and feasible, if adequate and strict preventive measures are vigorously and successfully carried out. | 2020-06-17 |
| 32527790 | In this review, we describe some of the important palliative care considerations that need to be incorporated into COVID-19 pandemic planning. […] The main aspects to be considered include decision algorithms for rationing care, training on effective symptoms management, alternative delivery methods of palliative care services such as telemedicine and finally death and bereavement support for surviving family members who are likely to be isolated from their loved one at the moment of death. | 2020-06-12 |
| 32527863 | The COVID-19 pandemic forces the whole rheumatic and musculoskeletal diseases community to reassemble established treatment and research standards. | 2020-06-12 |
| 32527868 | Only five patients (31%) were successfully treated with a single intravenous immunoglobulin (IVIg) infusion, while 10 patients (62%) required a second line of treatment. […] The Kawa-COVID-19 cohort differed from a comparator group of ‘classical’ KD by older age at onset 10 vs 2 years (p<0.0001), lower platelet count (188 vs 383 G/L (p<0.0001)), a higher rate of myocarditis 7/16 vs 3/220 (p=0.0001) and resistance to first IVIg treatment 10/16 vs 45/220 (p=0.004). | 2020-06-27 |
| 32528194 | CQ has been used for decades for the treatment and prophylaxis against malaria in endemic countries. […] This experience could be adapted to deploy CQ or HCQ for prophylaxis or treatment of COVID19 if strong evidence could be generated for these uses. | 2020-06-13 |
| 32528233 | Future research could target these inflammatory-immunological responses to develop effective therapy for COVID-19. | 2020-06-13 |
| 32528621 | Until now there is no real treatment of COVID-19 and many proposed drugs are under clinical trials. | 2020-06-17 |
| 32528622 | Until now there is no real treatment of COVID-19 and many proposed drugs are under clinical trials. | 2020-06-17 |
| 32528820 | Streamlined processes of detection, subsequent testing, isolation, and treatment by public health authority, was key in minimizing the risk of secondary transmission. | 2020-06-13 |
| 32529116 | We discuss potential treatment developments in the context of recent outbreaks, drug repurposing, and development timelines. | 2020-06-19 |
| 32529409 | Cryoablation is a minimally-invasive percutaneous procedure that is capable of reducing the psychosocial burden of surgical delay while also decreasing the morbidity of breast cancer therapy. | 2020-06-28 |
| 32529516 | After neurological examination, including a panel of blood cerebrospinal fluid biomarkers, a diagnosis of Miller Fisher syndrome (MFS) was hypothesized and intravenous immunoglobulin therapy (IVIG) was initiated. […] Fourteen days after the start of IVIG treatment, the patient has been discharged at home with the resolution of respiratory symptoms and only minor hyporeflexia at the lower limbs, without any side effect. | 2020-06-15 |
| 32529517 | In this article, we review currently available clinical data, and mechanisms for COVID-associated coagulopathy, and propose algorithms for screening, prevention (including extended-duration prophylaxis), and treatment of these patients. | 2020-06-18 |
| 32529545 | Since its genomic sequence has a notable similarity to that of SARS-CoV, antiviral drugs used to treat SARS and MERS are now being also applied for COVID-19 treatment. | 2020-06-15 |
| 32529737 | Two therapeutic strategies were compared: Group 1) minimization of calcineurin inhibitors (N=6); Group 2) cyclosporine-based therapy (N=23), with 15 patients switched from tacrolimus. […] Renal function did not deteriorate and signs of rejection were not observed in any patient on the second treatment regime. […] In conclusion, immunosuppressant treatment based on cyclosporine could be safe and effective for KTRs diagnosed with COVID-19. | 2020-06-23 |
| 32529795 | EMB-based identification of the cause of myocardial injury may contribute to explain the different evolution of complicated SARS-CoV-2-infection and to design future specific and personalized treatment strategies. | 2020-06-24 |
| 32529866 | With limited knowledge about SARS-CoV-2, no approved treatment or vaccine is available till date. | 2020-06-12 |
| 32529889 | Prevention and control of the pandemic and ensuring the progress of the cancer diagnosis and treatment is a significant problem in the current scenario. […] This article proposes a scientific management system for patients with solid tumors to guarantee emergency surgery, rationally arrange limited-term surgery, appropriately defer elective surgery, and guarantee regular chemotherapy, while protecting children from SARS-CoV-2 infection and ensuring the continuity of comprehensive diagnosis and treatment. | 2020-06-12 |
| 32530369 | New treatment options for patients with severe symptoms and ways of reducing transmission in the community are taken into consideration. […] Further studies are needed in order to evaluate the effectiveness of lopinavir/ritonavir in the treatment of patients with SARS-CoV-2 infection. | 2020-06-19 |
| 32530453 | This matched cohort study conducted in the general, vascular and thoracic surgery, orthopedic, and neurosurgery units of Spedali Civili Hospital (Brescia, Italy) included patients who underwent surgical treatment from February 23 to April 1, 2020, and had positive test results for COVID-19 either before or within 1 week after surgery. | 2020-06-12 |
| 32530776 | Prone positioning is a postural therapy that aims to enhance respiratory function through increasing oxygenation levels. | 2020-06-22 |
| 32530808 | Despite the high prevalence of the disease, it has currently no definitive treatment. […] Treatment with IVIG at the therapeutic dose of 0.3-0.5 g/kg can improve the clinical condition and O2 saturation and prevent the progression of pulmonary lesions in COVID-19 patients with severe symptoms in whom standard treatments have failed. | 2020-06-26 |
| 32530862 | Men and women living with HIV (N = 162) ages 20 to 37 participating in a longitudinal study of HIV treatment and care completed routine study measures and an assessment of COVID-19-related experiences. […] Social distancing and other practices intended to mitigate the spread of COVID-19 interfered with HIV care, and impeded access to food and medications, although an immediate adverse impact on medication adherence was not evident. | 2020-06-12 |
| 32530870 | Since 5-ASAs are a mainstay treatment for inflammatory bowel disease, the authors review the pharmacology of both classes of drugs and discuss the potential relevance of 5-ASAs in the ongoing discussion of medication use in patients infected with COVID-19. | 2020-06-12 |
| 32530889 | The global pandemic of coronavirus disease 2019 (Covid-19) may disproportionately affect persons in congregate settings, including those in residential substance use treatment facilities. […] We aimed to determine the point prevalence of SARS-CoV-2 in a residential treatment program setting and to understand the unique challenges of Covid-19 transmission in this setting. […] We performed a case series of SARS-CoV-2 rT-PCR testing via nasopharyngeal in a residential substance use treatment program for women in Boston. […] Staff and residents of the treatment program were tested for SARS-CoV-2. […] Based on test results, residents were cohorted by infection status and continued to participate in addiction treatment on-site. […] SARS-CoV-2 infection was common among staff and residents within a residential substance use treatment program for women in Boston. […] Universal SARS-CoV-2 testing in residential substance use programs can be instituted to reduce the risk of further transmission and continue addiction treatment programming when accompanied by adequate space, supplies, and staffing. | 2020-06-12 |
| 32531040 | To describe the characteristics of patients hospitalized with COVID-19 (including their long-term at-home medication use), and compare them with regard to the course of the disease. | 2020-06-26 |
| 32531046 | We focus on key aspects of the clinical trial pipeline including remote: 1) study recruitment and screening, 2) informed consent, 3) assessment, 4) biomarker collection, and 5) medication adherence monitoring. | 2020-06-12 |
| 32531110 | Based on diagnostic and treatment standards developed by EAACI, on international information regarding COVID-19, on guidelines of the World Health Organization (WHO) and other international organizations as well as on previous experience, a panel of experts including clinicians, psychologists, IT experts and basic scientists along with EAACI and the “Allergic Rhinitis and its Impact on Asthma (ARIA)” inititiative have developed recommendations for the optimal management of allergy clinics during the current COVID-19 pandemic. | 2020-06-12 |
| 32531119 | On day 35 post admission, while on therapy only with corticosteroids, he developed a symmetrically distributed maculopapular purpuric exanthema on the face, trunk and extremities (Fig.1 a,b). | 2020-06-12 |
| 32531129 | Therefore, with the objective of avoiding delay with the initiation of therapy and reducing the hazard of transport, we implemented a protocol for bedside ECMO cannulation. | 2020-06-24 |
| 32531138 | To date, little is known about the viral shedding duration, clinical course and treatment efficacy of COVID-19 near Hubei Province, China. […] The viral shedding duration, full clinical course and treatment efficacy were analysed in different subgroups of patients. […] Current treatment with any anti-viral agent or combination did not present the benefit of shortening viral shedding period and clinical course (all p > .05) in real-life settings. | 2020-06-25 |
| 32531236 | The general pharmacological characteristics, indications, adverse reactions, general usage, and especially current status of the treatment of COVID-19 of those potentially effective drugs, including chemical drugs, traditional Chinese medicines (TCMs), and biological products in China were summarized in this review to guide reasonable medication and the development of specific drugs for the treatment of COVID-19. | 2020-06-28 |
| 32531256 | This article reviews the mechanisms of SARS-CoV-2-induced cytokine storm in detail based on the current discovered researches, and put forward some valuable medication ideas for the targeted cytokines drug researches and treatment. | 2020-06-15 |
| 32531538 | The challenge is to control its rapid spread meanwhile looking for a specific treatment to improve patient outcomes. […] Hesperidin is a well-known herbal medication used as an antioxidant and anti-inflammatory agent. […] Available shreds of evidence support the promising use of hesperidin in prophylaxis and treatment of COVID 19. […] Herein, we discuss the possible prophylactic and treatment mechanisms of hesperidin based on previous and recent findings. […] Anti-viral activity of hesperidin might constitute a treatment option for COVID-19 through improving host cellular immunity against infection and its good anti-inflammatory activity may help in controlling cytokine storm. […] Based on that, hesperidin might be used as a meaningful prophylactic agent and a promising adjuvant treatment option against SARS-CoV-2 infection. | 2020-06-26 |
| 32531539 | OA with NPT treatment may have a role in optimization of bowel microcirculation and in the reduction of the endothelial and the systemic cytokine-related damage, improving also respiratory function. | 2020-06-26 |
| 32531620 | All articles that met criteria where analyzed for demographics, clinical, laboratory, radiographic, treatment and outcomes data. […] Various treatment regimens including interferon, antivirals, and hydroxychloroquine therapies have been trialed on the pediatric population but there are currently no studies showing efficacy of one regimen over the other. | 2020-06-25 |
| 32531754 | Natalizumab, approved for Multiple Sclerosis (MS) treatment, acts blocking α4-integrin. | 2020-06-26 |
| 32531808 | This, used in conjunction with robust in vitro and clinical data, can help in the assessment of COVID-19 therapeutics going forward. | 2020-06-12 |
| 32531948 | The recent exponential increase in the number of COVID-19 patients in Italy led to the adoption of specific extraordinary measures, such as the need to convey treatment of all non-deferrable cancer patients to specialized centres (hubs). […] Oncologic hubs must fulfil some specific requirements such as a high experience in oncologic patient treatment, strict strategies applied to remain a “COVID-19-free” centre, and the creation of a dedicated multidisciplinary “hub team”. […] Cancer treatment of patients who belong to external centres, namely spoke centres, could be organized in different pathways according to the grade of involvement and/or availability of the medical team of the spoke centre. […] Moreover, dedicated areas should be created for the management and treatment of patients who developed COVID-19 symptoms after hospitalization (i.e., dedicated wards, operation rooms and intensive care beds). | 2020-06-15 |
| 32532069 | Because there is no cure or treatment for this virus, it is emergingly urgent to find effective and validated methods to prevent and treat COVID-19 infection. […] In this context, alternatives related to nutritional therapy might help to control the infection. […] This narrative review proposes the importance and role of probiotics and diet as adjunct alternatives among the therapies available for the treatment of this new coronavirus. […] This review discusses the relationship between intestinal purine metabolism and the use of Lactobacillus gasseri and low-purine diets, particularly in individuals with hyperuricemia, as adjuvant nutritional therapies to improve the immune system and weaken viral replication, assisting in the treatment of COVID-19. | 2020-06-15 |
| 32532085 | The ongoing Coronavirus Disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) signals an urgent need for an expansion in treatment options. | 2020-06-19 |
| 32532356 | Patients have received other experimental treatment for COVID-19 within the last 30 days;2. […] Patients with severe renal insufficiency (estimated glomerular filtration rate <=30mL / min/1.73 m2) or patients receiving continuous renal replacement therapy, hemodialysis, peritoneal dialysis;4. […] Both will receive all necessary routine treatment for COVID-19. […] Six grades of ordered variables: GradeDescriptionGrade 1:Discharged of patient;Grade 2:Hospitalized without oxygen supplement;Grade 3:Hospitalized, oxygen supplement is required, but NIV / HFNC is not required;Grade 4:Hospitalized in intensive care unit, and NIV / HFNC treatment is required;Grade 5:Hospitalized in intensive care unit, requiring ECMO and/or IMV;Grade 6:Death. | 2020-06-22 |
| 32532449 | Here, in Part I of a duology on the characterization and potential treatment for COVID-19, we define severe COVID-19 as a consequence of the ability of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) to trigger what we now designate for the first time as a ‘Prolific Activation of a Network-Immune-Inflammatory Crisis’, or ‘PANIC’ Attack, in the alveolar tree. | 2020-06-16 |
| 32532461 | Treatment is tocilizumab. […] In other very similar CSS, such as macrophage activation syndrome (MAS) and hemophagocytic syndrome (HFS), the main treatment are corticosteroids. | 2020-06-16 |
| 32532691 | Passive immunotherapy with plasma derived from patients convalescent from SARS-CoV-2 infection can be a promising approach in the treatment of COVID-19 patients. | 2020-06-16 |
| 32532703 | There was consensus on postponing radical prostatectomy except for high-risk prostate cancer, and delaying treatment for low-grade bladder cancer, small renal masses up to T2, and stage I seminoma. | 2020-06-16 |
| 32532755 | Of all the late complications of diabetes, those involving the foot have traditionally required more face-to-face patient visits to clinics to treat wounds by debridement, offloading, and many other treatment modalities. | 2020-06-13 |
| 32532764 | Overwhelmingly, current best practice guidelines worldwide recommended the continuation of immunosuppression treatment in patients who require them except for perhaps high-dose corticosteroid therapy and in patients with associated risk factors for severe COVID-19 disease. | 2020-06-27 |
| 32532933 | To date, despite the whole world effort to review various aspects of SARS-CoV-2, including epidemiology, clinical manifestations, diagnosis, and treatment options, there are still gaps in the knowledge of this disease and many issues remain unclear. | 2020-06-22 |
| 32532939 | Hydroxychloroquine, lopinavir/ritonavir, remdesivir, umifenovir, favipiravir, ribavirin and beta-interferon-1 gave rise to variable but still inconsistent proof of clinical efficacy in the treatment of COVID-19. | 2020-06-22 |
| 32532948 | A 71-year old gentleman with history of arterial hypertension treated with valsartan presented on was hospitalized at the Infectious Diseases Unit, University of Bologna (Italy) for severe acute respiratory syndrome- coronavirus-2 (SARS-CoV-2) and received treatment with hydroxychloroquine 200mg bid (400 mg bid the first day), azithromycin 400 mg qd, thrombotic prophylaxis with enoxaparin 4000 UI qd and Venturi mask oxygen delivering FiO2 of 31%. […] Considering the available information we believe that LMWH may represent a promising treatment for COVID-19 but further well-designed trials are needed to address these points. | 2020-06-22 |
| 32533062 | Here, recent studies are summarized and reviewed, with a focus on virus-host interactions, vaccine-based and drug-targeted therapies, and the development of new approaches for clinical diagnosis and treatment. | 2020-06-28 |
| 32533071 | Ivermectin plays a role in several biological mechanisms, therefore it could serve as a potential candidate in the treatment of a wide range of viruses including COVID-19 as well as other types of positive-sense single-stranded RNA viruses. | 2020-06-16 |
| 32533166 | Many academics and researchers have responded to the COVID-19 pandemic by forming on-line national and international collaborative groups to rapidly investigate issues of prevention and treatment. | 2020-06-26 |
| 32533197 | AKI is associated with high mortality rates in this setting, especially when renal replacement therapy is required. […] To date, there is no specific treatment for COVID-19 induced AKI. […] A number of investigational agents are being explored for antiviral/immunomodulatory treatment of COVID-19 and their impact on AKI is still unknown. […] Indications, timing and modalities of renal replacement therapy currently rely on non-specific data focusing on patients with sepsis. | 2020-06-16 |
| 32533263 | The co-administration of hydroxychloroquine with azithromycin is proposed in COVID-19 therapy. | 2020-06-25 |
| 32533443 | The treatment of patients with community-acquired pneumonia (CAP), including SARS-CoV‑2 infections, should continue to be based on evidence-based CAP guidelines during the pandemic; however, COVID-19 specific adjustments are useful. […] The treatment of patients with chronic lung diseases has to be adapted during the pandemic but must still be guaranteed. | 2020-06-16 |
| 32533585 | Some therapeutics under investigation for COVID-19 may also have adverse cardiac effects. | 2020-06-13 |
| 32533662 | Thus, the pandemic has affected areas of economic management, magistral preparation, dispensing of medication to inpatients, ambulatory patients, patients monitored at home, institutionalized patients, and patients from private hospitals and field hospitals. | 2020-06-19 |
| 32533663 | These circumstances revealed the need to increase stocks of drugs, both for basic treatment as well as for specific SARS-CoV-2 infection management. | 2020-06-19 |
| 32533666 | Given that covid-19 affects elderly population with greater severity and many of them are polymedicated, great effort have been focused on monitoring interactions, both pharmacokinetic and pharmacodynamic (specially prolongation of the QT interval), monitoring correct concentrations of electrolytes, nutritional support, adaptation of chemotherapy treatment protocols and anticoagulant management, among others. | 2020-06-19 |
| 32533669 | Since the implementation of the Antimicrobial Therapy Optimization Programme, hospital pharmacy specialists have collaborated with infectious disease specialists on a regular basis in most hospitals in Spain. […] Realtime information sharing between different medicine specialties is an effective strategy to generate and maintain treatment protocols adapted to each center, with continuous evidence-based modifications as new publications appear. […] The most effective antiviral drug and anti inflammatory therapy remains elusive. | 2020-06-19 |
| 32533672 | In response to the SARS-CoV-2 pandemic, the Hospital Pharmacy Services have quickly adapted to respond to a critical situation characterized by the constant and continuous admission of patients with severe pneumonia who needed treatment, requiring a transformation of the hospital in order to increase the number of hospital and critical beds. […] Standard stocks were assigned for COVID units, and different dispensing circuits to avoid the risk of cross-contamination between COVID and non-COVID units were created, as well as disinfection protocols for medication transport systems and medication return protocols. […] All this without forgetting COVID treatment protocol’s changes that were affected by the availability of the drugs. […] The increase in the number of beds in out-of-hospital spaces, such as field hospitals, hotels, socio-medical centers and nursing homes, has challenged Pharmacy Services, since new medication dispensing and conciliation circuits have been created forcing the increase of pharmacy staff’s presence and modifying work shifts, to afford all the new tasks successfully. | 2020-06-19 |
| 32533673 | The constitution of a multidisciplinary Pharmacy and Therapeutics Committee let agree to a pharmacotherapy guide, pres cription protocols, therapeutic equivalences, interactions, and drug dispensing circuits. | 2020-06-19 |
| 32533674 | With regard to remote outpatient pharmacy services, teleconsultation with drug dispensing has been promoted based on five basic procedures, each with its advantages and limitations: home drug delivery from HPSs, with the advantage of universal access and the limitation of entailing a substantial investment in resources; HPS coordination with primary care pharmacists, which requires no investments but with limited access to some geographic areas; HPS coordination with community pharmacists based on a large network of pharmacies, which requires the patient to go to the pharmacy, without confidentiality being guaranteed for any patient; geolocation and hospital-based medication dispensing, which provides universal access and direct traceability, but entails investment in human resources; and HPS coordination with associations of patients, which does not entail any additional cost but limits the information available on the diseases of society members. […] Three main lessons have been learned during the pandemic: the satisfactory capacity of HPS to provide outpatient pharmacy consultation services in the setting of a public health crisis; the usefulness of Telepharmacy for the clinical follow-up, healthcare coordination, outpatient counseling, and informed dispensing and delivery of medication (with a high level of satisfaction among patients); and the need to foster Telepharmacy as a complementary tool through a mixed model of outpatient pharmacy consultation service that incorporates the advantages of each procedure and adapts to the individual needs of each patient in a context of humanized healthcare. | 2020-06-19 |
| 32533675 | The Spanish Agency for Medicines and Medical Devices (AEMPS), in coordination with Institutional Review Boards, has adopted a fast-track review procedure to accelerate authorizations for CTs related to the treatment or prevention of COVID-19. | 2020-06-19 |
| 32533799 | The necessity to employ distance-based methods to deliver on-going eating disorder care due to the novel coronavirus (COVID-19) pandemic represents a dramatic and urgent shift in treatment delivery. […] Based on clinical experience within our clinic and research programs, we aim to highlight the common challenges clinicians may encounter in providing family-based treatment (FBT) via TeleHealth for children and adolescents with anorexia nervosa and bulimia nervosa. […] Additional research in TeleHealth treatment for eating disorders in youth may lead to improved access, efficiency, and effectiveness of FBT delivered via videoconferencing. | 2020-06-13 |
| 32533844 | In the absence of a clearly defined temporal connection, the relationship between exanthems and SARS-CoV-2 infection is at times unclear, as in the case of urticarial/maculopapular eruptions in patients undergoing treatment with multiple drugs. | 2020-06-13 |
| 32533848 | 1] One purpose of the report was to advise restructuring of healthcare services by limiting them to urgent or emergent cases in order to reduce pressure on the intensive care units (ICU) of hospitals treating COVID-19-positive patients. | 2020-06-13 |
| 32533868 | The challenges to advance CCP therapy are different between HICs and LMICs. | 2020-06-13 |
| 32534013 | Thus, fast and accurate diagnostic methods are of great significance for prevention and accurate treatment. | 2020-06-16 |
| 32534094 | These properties look very promising considering the COVID-19 epidemy and allow propose that Panavir® would be effective in the therapy of the SARS-CoV-2 infection. | 2020-06-27 |
| 32534129 | Although the PD program was successful in its ability to provide much-needed kidney replacement therapy (KRT) when hemodialysis was not available, challenges to delivering adequate PD dosage included difficulties in providing nurse training and availability of supplies. […] Providing adequate clearance and ultrafiltration for patients in intensive care units was especially difficult due to high prevalence of hypercatabolic state, volume overload, and prone positioning. | 2020-06-16 |
| 32534175 | New ways of screening the general population for COVID-19 are urgently needed along with novel effective prevention and treatment strategies. […] A hypothetical three-part prevention, diagnostic, and treatment approach based on an up-to-date scientific literature review for COVID-19 is proposed. […] Third, concerning treatment, COVID-19 induced inflammation and “cytokine storm syndrome” with hemophagocytic lymphohistiocytosis (HLH)/Macrophage Activation Syndrome (MAS) have resulted in extreme morbidity and mortality in those with certain comorbidities, secondary to “acute respiratory distress syndrome” (ARDS) and multiorgan dysfunction with disseminated intravascular coagulation (DIC). […] Since high mortality rates from sepsis induced DIC due to COVID-19 infection has also been associated with thrombotic events and elevated levels of D-dimer, randomized controlled trials of using anticoagulant therapy with heparin is urgently required. […] A three-part prevention, diagnostic, and treatment plan is proposed for addressing the severe complications of COVID-19. […] Digital monitoring of symptoms to clinically diagnose early exposure and response to treatment; prevention with ivermectin as well as nutritional therapies that support a healthy immune response; treatment with anti-inflammatory therapies that block NF-κB and activate Nrf2 pathways, as well as novel therapies that address COVID-19 pneumonia and ARDS with DIC including anticoagulation and/or novel respiratory therapies with or without acetazolamide and sildenafil. | 2020-06-16 |
| 32534187 | We also discuss the clinical application prospects and limitations of 3CLpro inhibitors for COVID-19 treatment. | 2020-06-16 |
| 32534188 | Currently, the existing treatment is essentially supportive and role of antiviral agents is yet to be established as there is no vaccination or therapy available. | 2020-06-16 |
| 32534189 | Since the most severe clinical manifestation of COVID-19 appeared to be a severe acute respiratory syndrome, azithromycin has been proposed as a potential treatment. | 2020-06-16 |
| 32534226 | Coronavirus disease 2019 (COVID-19) is expanding rapidly, which made it as one of top priorities for scientists to develop novel treatment strategies. […] As well as studies on patients who are plasma therapy, the patient’s condition shows improvement. […] The evidence for these studies is very promising and demonstrates the potential of monoclonal antibody therapy as a therapeutic approach and prevention of covid-19 infection. | 2020-06-26 |
| 32534337 | Importantly, rhein inhibits the interaction between the SARS-CoV S protein and ACE2 in a dose-dependent manner, suggesting rhein as a potential therapeutic agent for the treatment of SARS-CoV infection. […] Based on these findings, we hypothesize that DAR is a multi-target drug useful for COVID-19 treatment. | 2020-06-26 |
| 32534369 | Despite these warnings, in several developing countries the official guidelines for treatment of Covid-19 patients at the primary care level recommend Hydroxychloroquine and azithromycin, among other treatments, as the first-choice for mild symptomatic Covid-19 patients, asymptomatic contacts or for prophylaxis. | 2020-06-23 |
| 32534451 | In the present work, we present evidence that low-dose lithium can reduce the SASP of human iPSCs-derived astrocytes following acute treatment, suggesting that microdose lithium could protect cells from senescence and development of aging-related conditions. | 2020-06-26 |
| 32534467 | With an emphasis on immune modulation, we also look at ongoing clinical studies aimed at blocking proinflammatory cytokines; transfer of immunosuppressive mesenchymal stem cells; use of convalescent plasma transfusion; as well as immunoregulatory therapy and traditional Chinese medicine regimes. […] By better understanding the mechanisms that drive the intensity of a cytokine storm, we can tailor treatment strategies at specific disease stages and improve our response to this worldwide public health threat. | 2020-06-13 |
| 32534807 | Here, in Part II of a duology on the characterization and potential treatment for COVID-19, we characterize the application of an innovative treatment regimen for the prevention of the transition from mild to severe COVID-19, as well as detail an intensive immunotherapy intervention hypothesis. […] Further, we describe a preventative treatment intervention regimen for those designated as having mild to moderate COVID-19 disease, but who exhibit features which herald the transition to the severe variant of this disease. | 2020-06-14 |
| 32534808 | Overall, 355 patients had active treatment during the study period due to newly diagnosed or recurrent gynecological disease. […] More important, patients under active treatment for cancer are at high risk of developing severe evolution of COVID-19. | 2020-06-14 |
| 32534848 | Subjects with obesity affected by COVID-19 require longer hospitalization, more intensive and longer oxygen treatment, and they may have longer SARS-COV-2 shedding. | 2020-06-28 |
| 32534910 | Preliminary data suggest that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is associated with higher mortality among cancer patients, particularly in those on systemic therapy. […] These data suggest that the higher risk of COVID-19 death associated with systemic therapy in cancer may not apply to patients on ICIs. […] Assessment of COVID-19 severity in these patients can be complicated by the underlying cancer and its treatment. | 2020-06-14 |
| 32534945 | Overall, 71.6% of patients were admitted to hospitals and 4.7% required ICU treatment. | 2020-06-14 |
| 32534946 | The knowledge of available laboratory methods is essential for early and correct diagnosis of COVID-19 to identify new cases as well as monitoring treatment of confirmed cases. | 2020-06-14 |
| 32534969 | Following a COVID-19 outbreak, 101 patients with advanced genitourinary cancers are currently managed “virtually” for therapy administration at our tertiary care unit. […] Anxiety of cancer (6/10, interquartile range [IQR] 3-8) superseded that of COVID-19 (four/10, IQR 2-5.25, p<0.001), and patients oppose temporary treatment interruption. […] Of the patients, 66.0% perceive their susceptibility to COVID-19 as equal to or lower than the general population and 52.2% believe that COVID-19 will not affect their therapy. […] Beyond the crisis, maintaining telehealth has low preference rates (four/10, IQR 2-7), with high acceptance for external laboratory controls (60.9%) and online visit management (48.9%), but lower acceptance for remote treatment planning including staging discussions (44.6%) and for referral to secondary care oncologists (17.4%). […] Despite the pandemic, cancer remains the key concern and patients are not willing to compromise on their treatment. | 2020-06-14 |
| 32535032 | Coronavirus infection is a serious health problem awaiting an effective vaccine and/or antiviral treatment. | 2020-06-14 |
| 32535080 | After all the simulations and predictions here performed, we obtained 10 top-ranked compounds that were again in silico analyzed inside the Mpro catalytic site, together some drugs that are being currently investigated for treatment of COVID-19. […] After proposing and analyzing the interaction modes of these compounds, we submitted one molecule then selected as template to a 2D similarity study in a database containing drugs approved by FDA and we have found and indicated Apixaban as a potential drug for future treatment of COVID-19. | 2020-06-28 |
| 32535294 | A positive response to COVID-19-specific treatment in the SARS-CoV-2 positive SSNHL patient was noted. […] Awareness of such a non-specific presentation of COVID-19 patients is crucial during this pandemic period for preventing infectious spread through isolation and early initiation of COVID-19 targeted treatment. | 2020-06-28 |
| 32535298 | The Rt continued to decline following additional measures in line with the policy of “early detection, early report, early quarantine and early treatment”. | 2020-06-14 |
| 32535509 | An option currently being explored for the treatment of COVID-19 is the use of interferons (INFs), either alone or in combination with other antiviral agents. | 2020-06-26 |
| 32535547 | Based on the most recently available data both about the novel coronavirus and the approved immunotherapies for neurological diseases, we provide an updated overview that includes current treatment strategies and the associated COVID-19 risk, but also the potential of immunotherapies to treat COVID-19. | 2020-06-28 |
| 32535573 | We also made recommendations on prophylaxis and patients treatment in cases of COVID-19 and diabetes mellitus co-morbidity. | 2020-06-18 |
| 32535705 |
|
2020-06-23 |
| 32535732 | At present, there are no proven agents for treatment of coronavirus disease (COVID-19). […] IL-6 inhibitors could be one such treatment option, with generation of more evidence and completion of a larger number of systematic studies. | 2020-06-17 |
| 32535752 | The pandemic has united researchers from bench to bedside in attempts to understand the pathophysiology of the disease and define optimal treatment strategies. […] Additionally, there are concerns about the cardiac effects of the numerous treatment agents under study. | 2020-06-17 |
| 32535837 | The most common management decisions were medication prescription (102 visits, 46%) or reassurance (86 visits, 39%), while 17 video visit patients (8%) were escalated to an urgent, in-person evaluation. | 2020-06-17 |
| 32535870 | Perspectives are provided on: (1) maintaining a safe environment for surgical oncology care; (2) redirecting the multidisciplinary model to guide surgical decisions; (3) harnessing telemedicine to accommodate requisite physical distancing; (4) understanding interactions between SARS CoV-2 and cancer therapy; (5) considering the ethical impact of professional guidelines for surgery prioritization; and (6) advocating for our patients who require oncologic surgery in the midst of the COVID-19 pandemic. | 2020-06-17 |
| 32535877 | We collect data on epidemiology, demography, medical history, symptoms, clinical course, and pathogen testing and treatment. | 2020-06-17 |
| 32535894 | In multivariable analysis, anti-inflammatory treatment was independently associated with the development of BSI (cause-specific hazard ratio [csHR] 1.07 with 95% CI 0.38-3.04 for tocilizumab, csHR 3.95 with 95% CI 1.20-13.03 for methylprednisolone, and csHR 10.69 with 95% CI 2.71-42.17 for methylprednisolone plus tocilizumab, with no anti-inflammatory treatment as the reference group; overall p for the dummy variable = 0.003). | 2020-06-14 |
| 32535946 | Data comprised of demographic data, current occupation (shown in Table 1), duration of symptoms, past medical history, regular medication and treatment interventions. | 2020-06-14 |
| 32535955 | This paper answers pressing questions, formulated by young clinicians and scientists, on SARS-CoV-2, COVID-19 and allergy, focusing on the following topics: virology, immunology, diagnosis, management of patients with allergic disease and asthma, treatment, clinical trials, drug discovery, vaccine development and epidemiology. | 2020-06-14 |
| 32536150 | To compare the virological and clinical responses to lopinavir-ritonavir and hydroxychloroquine treatment in COVID-19 patients. […] The median duration of symptoms before treatment was 7 days and 26 patients (40%) required oxygen support at baseline. […] Treatment with lopinavir-ritonavir (adjusted hazard ratio [aHR], 2.28; 95% confidence interval [CI], 1.24 to 4.21) and younger age (aHR, 2.64; 95% CI 1.43 to 4.87) was associated with negative conversion of viral RNA. | 2020-06-15 |
| 32536226 | Therefore, further studies, particularly in the context of the virus pathogenesis, diagnosis, treatment, and vaccine development, are warranted. | 2020-06-15 |
| 32536457 | Highlighting the experience gained from targeting Nsp13 in similar coronaviruses (SARS-CoV and MERS) and known inhibitors, the article calls for research on helicase inhibitors as potential COVID-19 therapy. | 2020-06-19 |
| 32536480 | No type of biologic therapy should be suspended, unless there are signs of COVID-19. […] Finally, biologic treatment with anti-TNF-alpha agents or any other mechanism of action, such as anti-integrins or anti-interleukins, should be suspended if patients become infected with SARS-CoV-2. | 2020-06-19 |
| 32536516 | The patient improved after antiviral treatment but eventually developed severe respiratory distress syndrome and cardiac insufficiency. […] The patient was finally intubated and transferred to a higher-level care centre for further treatment. […] We were very focused on infectious disease protection throughout the treatment, however, suboptimal treatment was provided due to the switch in antihypertensive medication, lack of early nutritional support and fluid restriction management. | 2020-06-19 |
| 32536564 | Notably, there has been no specific, clinically approved vaccine or anti-viral treatment strategy for COVID-19. | 2020-06-15 |
| 32536632 | The current treatment for cytokine storms is limited, so the international medical community is focusing on a specific and effective remedy. […] Jaktinib hydrochloride has great potential for the treatment of patients with coronavirus disease 2019 (COVID-19). | 2020-06-15 |
| 32536670 | In light of the recent pandemic, favipiravir (Avigan®), a purine nucleic acid analog and antiviral agent approved for use in influenza in Japan, is being studied for the treatment of coronavirus disease 2019 (COVID-19). […] Here, we discussed the mechanism of blood uric acid elevation during favipiravir treatment. […] Elevated uric acid levels were returned to normal after discontinuation of favipiravir, and favipiravir is not used for long periods of time for the treatment of viral infection. | 2020-06-19 |
| 32536734 | While the COVID-19 prevention intervention tests now being run for several promising vaccines are true experiments, the researchers analyzing the data from these interventions may need prompting to examine the efficacy of each vaccine tested by modeling demographic subgroups for the members in the treatment and placebo groups in the randomized control trials. | 2020-06-15 |
| 32536759 | Presently, COVID-19 has posed a serious threat to researchers, scientists, health professionals, and administrations around the globe from its detection to its treatment. | 2020-06-15 |
| 32536762 | Until now, there is no known safe treatment, hence the immunity system of the individual has a crucial role in recovering from this contagious disease. | 2020-06-15 |
| 32536965 | The traditional Chinese medicine prescription Dayuanyin (DYY), a classic prescription for the treatment of plague, has shown significant effects in the treatment of COVID-19. […] This study aims to explore the mechanism of action of DYY in the treatment of COVID-19 with the hope of providing a theoretical basis for its clinical application. […] First, 174 compounds, 7053 target genes of DYY and 251 genes related to COVID-19 were selected, among which there were 45 target genes of DYY associated with treatment of COVID-19. […] This study demonstrated that the use of DYY in the treatment of COVID-19 involved a variety of biological processes, and DYY acted on key targets such as IL6, ILIB, and CCL2 through signaling pathways such as the IL-17 signaling pathway, AGE-RAGE signaling pathway in diabetic complications, and cytokine-cytokine receptor interaction. | 2020-06-15 |
| 32536988 | Supportive care remains the mainstay of therapy at present, as it is still unclear how well these data can be extrapolated to SARS-CoV-2. […] In this review, we summarize the strategies currently employed in the treatment of COVID-19. | 2020-06-15 |
| 32537099 | The results of a clinical trial comparing hydroxychloroquine with or without azithromycin to the standard of care for the treatment of COVID-19 were recently published by Philippe Gautret et al. […] This study provides outstanding results for the combination of hydroxychloroquine and azithromycin over the standard of care, but the evidence was deemed insufficiently robust to warrant a public health decision to widen the use of hydroxychloroquine for the treatment of COVID-19. […] The study has a number of limitations, including small sample size, lack of comparability between patients in active treatment and control arms, lack of blinding, use of interim analyses without controlling for the risk of type 1 error, use of analysis in the per-protocol population instead of the intention-to-treat population, and inconsistencies between the study protocol and article. | 2020-06-15 |
| 32537140 | Surgeons worry, that whilst healthcare-resources are directed against the pandemic, double effect may predict these benevolent public health efforts will cause unintended maleficent effects through delays to surgical treatment. | 2020-06-15 |
| 32537272 | Given the incomplete understanding of the virus at this time, healthcare professionals must continue to remain informed of the vast number of clinical presentations of the virus to ensure early supportive treatment, ideally leading to improved outcomes. | 2020-06-15 |
| 32537481 | For treating viral infections and cancer therapy, we discuss potential size- and lipid-type-based selectivity principles for developing membrane active nanomedicine. | 2020-06-15 |
| 32537482 | In addition, two other biologically active compounds, Mupirocin (DB00410) and Simvastatin (DB00641) could be an option for the treatment of viral infections. | 2020-06-15 |
| 32537483 | These systems allow patients to recover and receive treatment in their homes and among their families, where patient health and the hospitalization room environmental state are monitored, to enable doctors to follow the hospitalization process and make recommendations to patients and their supervisors, through monitoring units and mobile applications developed for this purpose. | 2020-06-15 |
| 32537529 | EEG findings were correlated with demographic data, clinical presentation and history, and medication usage. | 2020-06-25 |
| 32537610 | While there is no specific treatment for severe acute lung injury (ALI) and ARDS due to the COVID-19 and the management is mostly supportive, it is very important to better understand the pathophysiological processes activated by the inflammatory mediators such as cytokines and metalloproteinases with the aim of their subsequent inhibition in the course of the complex treatment. […] Experimental data support that the use of aprotinin to inhibit MMPs and KKS may be a new potential approach to the treatment of ALI / ARDS. | 2020-06-15 |
| 32537615 | To determine the usefulness of social media for rapid communication with experts to discuss strategies for prioritization and safety of deferred treatment for urologic malignancies during COVID-19 pandemic, and to determine whether the discourse and recommendations made through discussions on social media (Twitter) were consistent with the current peer-reviewed literature regarding the safety of delayed treatment. […] We reviewed and compiled the responses to our questions on Twitter regarding the management and safety of deferred treatment in the setting of COVID-19 related constraints on non-urgent care. […] Further, we analyzed peerreviewed literature on the safety of deferred treatment (surgery or systemic therapy) to make made evidence-based recommendations. […] We did not find evidence to support the idea of using nonsurgical therapies, such as hormone therapy for prostate cancer or chemotherapy for bladder cancer for safer deferment of previously planned surgery. […] These real-time communications via Twitter provided sound guidance which was readily available to the public and participants, and was generally in concordance with the peerreviewed data on safety of deferred treatment. | 2020-06-15 |
| 32537662 | Consequently, treatment of these patients should include careful guideline-conform cardiovascular evaluation and treatment. […] Thus, formation of a competent Cardio-COVID-19 team may represent a major clinical measure to optimize therapy of cardiovascular patients during this pandemic. | 2020-06-19 |
| 32537687 | We aimed to assess the impact of such measures on thyroid cancer treatment plans. […] Since papillary carcinoma was the preoperative diagnosis in all cases, radioactive iodine ablation (RIA) therapy was also planned 3-4 weeks following surgery after withdrawing thyroxine and achieving a thyroid stimulating hormone (TSH) level > 30 mU/L. […] However, the RIA treatment plan was altered considerably according to the period in which they were operated. 6 out of the 7 patients operated in March changed to the stimulated method of RIA at a considerable additional extra cost. | 2020-06-19 |
| 32537704 | In this review, we discuss how to appropriately identify high-risk patients for GIB and how to mitigate GIB risk with proton-pump inhibitor co-therapy, medication reconciliation, and Helicobacter pylori testing and treating in this complex and morbid population. | 2020-06-19 |
| 32537771 | We chose the first 30 videos for seven different search phrases: “2019 nCoV,” “SARS CoV-2,” “COVID-19 virus,” “coronavirus treatment,” “coronavirus explained,” “what is the coronavirus” and “coronavirus information.” Video contents were evaluated by two independent medical students with more than 5 years of experience using the DISCERN instrument. | 2020-06-15 |
| 32537957 | The outcome measures were in-hospital mortality and the treatment with mechanical ventilation (MV) or high-flow nasal cannula (HFNC). | 2020-06-18 |
| 32537960 | We review similarities in disease presentation between infection and allergy, relevant immunopathology, and outline phases of SARS-CoV-2 disease with perspectives on therapy and critical care. | 2020-06-15 |
| 32537961 | The insights from these data will be useful in determining the treatment policies and preventive measures of COVID-19. | 2020-06-15 |
| 32538003 | This article proposes the theoretical feasibility and reliability of acupuncture and moxibustion interventional prevention and treatment by discussing the recognition of coronavirus disease 2019 (COVID-19) from the perspective of acupuncture and moxibustion. […] The unique “acupuncture and moxibustion program” for COVID-19 is presented including treatment in different stages, selecting acupoints by distinguishing meridians, applying needle technique by various methods. | 2020-06-17 |
| 32538004 | To observe clinical effect of heat-sensitive moxibustion on coronavirus disease 2019 (COVID-19) and to discusses the effective moxibustion treatment program. […] The treatment was conducted under the standards of heat-sensitive moxibustion manipulation, which were “locating acupoint by feeling, moxibustion by differentiate sensation, dosage varies individually, ending after sufficient dosage”. […] The incidence of deqi after first heat-sensitive moxibustion, the reduction of negative emotions, the improvement of chest distress and impaired appetite, and the active acceptance rate of moxibustion before and after treatment were observed. […] ② The incidences of feeling relaxed and comfortable immediately after the first, second, and third heat-sensitive moxibustion were 61.9% (26/42), 73.8% (31/42), and 92.9% (39/42), which were higher than 42.9% (18/42) before heat-sensitive moxibustion treatment (P<0.05). […] ③ The incidences of chest distress after the first, second, and third heat-sensitive moxibustion were 23.8% (10/42), 16.7% (7/42), and 9.5% (4/42), which were lower than 50.0% (21/42) before heat-sensitive moxibustion treatment (P<0.05); the incidences of impaired appetite after the first, second, and third heat-sensitive moxibustion were 26.2% (11/42), 19.0% (8/42), 9.5% (4/42), which were lower than 57.1% (24/42) before heat-sensitive moxibustion treatment (P<0.05). […] ④ After the first treatment, the active acceptance rate of patients for heat-sensitive moxibustion was 100.0% (42/42), which was higher than 11.9% (5/42) before heat-sensitive moxibustion (P<0.05). […] It is generally accepted by patients, and worthy of popularization and application in clinical treatment. | 2020-06-17 |
| 32538025 | High number of intensive care unit beds and ventilators, national treatment algorithms, governmental support for free testing and medications, tedious contact-tracing with early detection and isolation of cases together with early shelter-in-place for the elderly and youngsters, and subsequent weekend curfews in selected cities have so far prevented the surge pressure on the health care system. | 2020-06-19 |
| 32538209 | Herein, we represented possible therapeutic agents that may stand as a potential therapy against COVID-19. […] A combination, at least dual or even triple therapy, of the aforementioned efficacious and safe therapies is greatly recommended for COVID-19. | 2020-06-15 |
| 32538276 | To date, there is no confirmed treatment or vaccine prevention strategy against COVID-19. […] Due to the urgent need for effective treatment, drug repurposing is regarded as the immediate option. | 2020-06-19 |
| 32538594 | ARDS is responsible for one in 10 admissions to intensive care units and one in four mechanical ventilations. […] Treatment of ARDS is supportive and includes mechanical ventilation, prophylaxis for stress ulcers and venous thromboembolism, nutritional support, and treatment of the underlying injury. | 2020-06-16 |
| 32538597 | When empiric treatment is appropriate, suggested antibiotics include ceftriaxone or cefotaxime for infants one to three months of age and ampicillin with gentamicin or with cefotaxime for neonates. | 2020-06-25 |
| 32538646 | Parent-Child Interaction Therapy (PCIT) is particularly well-positioned to address some of the most pressing child and parental needs that arise during stressful times, and telehealth formats of PCIT, such as Internet-delivered PCIT (iPCIT), have already been supported in controlled trials. | 2020-06-15 |
| 32538648 | In responding to the 2019 novel coronavirus (COVID-19), health-care workers have been exposed to a range of traumatic experiences, including the management of ventilators; provision of treatment; and issues with access to and the use of personal protective equipment. | 2020-06-15 |
| 32538775 | It is also critical that we adopt these new pathways to the treatment of pregnant women affected by SARS-CoV-2, based on the scientific data we use to treat the general population. | 2020-06-26 |
| 32538803 | Health resources and facilities are being destined for the treatment of critically ill infected patients. | 2020-06-18 |
| 32538804 | In a great effort to standardize the management and treatment guidelines, the different health authorities and scientific associations have tried to issue recommendations on how to act in this new and complex scenario. | 2020-06-18 |
| 32538805 | Kidney cancer scenarios are quite different depending on their stage, distinguishing mainly between low priority of localized disease or high priority of locally advanced and metastatic under active treatment. | 2020-06-18 |
| 32538806 | The risk of severe morbidity as a result of SARS-CoV-2 infection may out weigh the risk of PC morbidity/mortalityin many men; therefore, in the short term it is unlikely that delays in diagnosis or treatment can led to worse cancer outcomes. […] The COVID-19 pandemic has resulted in a challenge for our health system, which raises several considerations in the treatment of patients with PC. | 2020-06-18 |
| 32538807 | RESULTS: Different proposals for treatment and follow-up of patients diagnosed with bladder cancer adjusted for oncological risk and the different phases of the pandemic are presented. | 2020-06-18 |
| 32538808 | The resulting manuscript was critically revised by national authors in order to establish common criteria about treatment and follow up. […] EVIDENCE SYNTHESIS: Four studies were identified that assessed the impact of delaying radical nephrouretrectomy as curative treatment. […] CONCLUSIONS: A delay in curative treatment of upper tract urothelial tumours for more than three months results in adverse outcomes as overal survival and cancer specific survival. | 2020-06-18 |
| 32538809 | Initial diagnostic procedures for testicular cancer such as scrotal US, orchiectomy, staging CT and adjuvant treatment (if required) are priority. […] Reducing the usage of chemotherapy with respiratory toxicity and increasing the usage ofgrowth factors during chemotherapy treatment are the main stakeholders of treatment. | 2020-06-18 |
| 32538810 | Clear diagnostic and treatment criteria and referral criteria must be established. […] The diagnosis and prescription of treatment for BPH during the COVID-19 pandemic should be based on telemedicine and joint protocols for primary care attention and urology. […] Elective surgical treatment can be delayed until we are in phases I or II, individualizing the surgical and anaesthetic technique of choice to minimize risks. | 2020-06-18 |
| 32538812 | Offer some recommendations or guidelines during the evolution of the COVID-19 pandemic in terms of diagnosis, treatment and follow-upin the field of Reconstructive Urology. | 2020-06-18 |
| 32538813 | MATERIAL AND METHODS: Experts in Functional Urology from different autonomous communities of Spain were contacted to design a strategy to reorganize the activity of both, diagnosis and treatment. | 2020-06-18 |
| 32538814 | A classification is provided prioritizing conservative/outpatient management and the surgical treatment of the events occurring in neurourological patients during the COVID-19 pandemic. […] CONCLUSIONS: In neurourological patients we can find exceptional clinical situations in which a delayed treatment could develop irreversible changes in the upper urinary tract, advocating a more urgent treatment inspecific scenarios. | 2020-06-18 |
| 32538815 | The objective of this article is to establish strategies and recommendations for the treatment and follow-up in COVID-19 pandemic in phases I, II and III, based on available scientific evidence and the consensus of a group of experts in these pathologies. […] CONCLUSION: Treatment of Urolithiasis in COVID-19 pandemic calls for prioritization of patients, maximum efficiency in treatments, adequate protection of healthcare personnel, and the implementation of telemedicine as a measure to reduce patient attendance to the hospital. | 2020-06-18 |
| 32538820 | The Goddess of Health had two daughters, Panacea and Higinia, the fruit of the first is diagnosis, prognosis and treatment, and the fruit of the second is health management, prevention, and statistics. | 2020-06-18 |
| 32538831 | In the face of the lack of an antiviral treatment and the lack of a protective vaccine one must state Taiwan has made the best out of the pandemic situation whereas Sweden failed completely. | 2020-06-15 |
| 32538870 | Along with these new care models, digital therapeutics, defined as treatments delivered through software programs, are emerging. | 2020-06-15 |
| 32538995 | Non-invasive mechanical ventilation and high-flow oxygen therapy are not recommended due to the generation of aerosol (associated with risk of viral spread among health personnel), and neither is extracorporeal membrane oxygenation or the use of steroids. […] So far, there is no specific antiviral treatment for patients with COVID-19, and neither are there results of controlled trials supporting the use of any. | 2020-06-22 |
| 32539257 | Because of its dynamic, real-time, non-invasive, repeatable and other advantages, critical ultrasonography can be widely used in the diagnosis, assessment and guidance of treatment for severe patients. […] Based on the recommendations of critical care experts from all over the country who fight against the epidemic in Wuhan, this article summarizes the guidelines for the treatment of COVID-19 based on critical ultrasonography, hoping to provide help for the treatment of severe patients. […] The recommendations mainly cover the following aspects: (1) lung ultrasound in patients with COVID-19 is mainly manifested by thickened and irregular pleural lines, different types of B-lines, shred signs, and other consolidation like dynamic air bronchogram; (2) Echocardiography may show right heart dysfunction, diffuse cardiac function enhancement, stress cardiomyopathy, diffuse cardiac depression and other multiple abnormalities; (3) Critical ultrasonography helps with initiating early treatment in the suspect patient, screening confirmed patients after intensive care unit admission, early assessment of sudden critical events, rapid grading assessment and treatment based on it; (4) Critical ultrasonography helps to quickly screen for the etiology of respiratory failure in patients with COVID-19, make oxygen therapeutic strategy, guide the implementation of lung protective ventilation, graded management and precise off-ventilator; (5) Critical ultrasonography is helpful for assessing the circulatory status of patients with COVID-19, finding chronic cardiopulmonary diseases and guiding extracorporeal membrane oxygenation management; (6) Critical ultrasonography Contributes to the management of organs besides based on cardiopulmonary oxygen transport; (7) Critical ultrasonography can help to improve the success of operation; (8) Critical ultrasonography can help to improve the safety and quality of nursing; (9) When performing critical ultrasonography for patients with COVID-19, it needs to implement three-level protection standard, pay attention to disinfect the machine and strictly obey the rules from nosocomial infection. […] (10) Telemedicine and artificial intelligence centered on critical ultrasonography may help to improve the efficiency of treatment for the patients with COVID-19. […] In the face of the global spread of the epidemic, all we can do is to share experience, build a defense line, We hope this recommendations can help COVID-19patients therapy. | 2020-06-16 |
| 32539378 | At this time, no specific prophylactic or postexposure therapy for COVID-19 are currently available. | 2020-06-26 |
| 32539876 | We describe a widespread laboratory surveillance program for severe acute respiratory coronavirus virus 2 (SARS-CoV-2) at an integrated medical campus that includes a tertiary-care center, a skilled nursing facility, a rehabilitation treatment center, and temporary shelter units. | 2020-06-25 |
| 32539942 | Patients of any age, sex, histology, or stage were considered eligible, including those in active treatment and clinical follow-up. […] Between March 26 and April 12, 2020, 200 patients with COVID-19 and thoracic cancers from eight countries were identified and included in the TERAVOLT registry; median age was 68·0 years (61·8-75·0) and the majority had an Eastern Cooperative Oncology Group performance status of 0-1 (142 [72%] of 196 patients), were current or former smokers (159 [81%] of 196), had non-small-cell lung cancer (151 [76%] of 200), and were on therapy at the time of COVID-19 diagnosis (147 [74%] of 199), with 112 (57%) of 197 on first-line treatment. 152 (76%) patients were hospitalised and 66 (33%) died. 13 (10%) of 134 patients who met criteria for ICU admission were admitted to ICU; the remaining 121 were hospitalised, but were not admitted to ICU. […] Univariable analyses revealed that being older than 65 years (OR 1·88, 95% 1·00-3·62), being a current or former smoker (4·24, 1·70-12·95), receiving treatment with chemotherapy alone (2·54, 1·09-6·11), and the presence of any comorbidities (2·65, 1·09-7·46) were associated with increased risk of death. […] Whether mortality could be reduced with treatment in intensive care remains to be determined. | 2020-06-19 |
| 32539986 | A combination of RT-PCR and serology should be implemented for case finding and contact tracing to facilitate early diagnosis, prompt isolation, and treatment. | 2020-06-19 |
| 32539988 | We defined asymptomatic infection as SARS-CoV-2 infection with no history of clinical signs and symptoms, severe COVID-19 as clinical symptoms of pneumonia (dyspnoea, tachypnoea, peripheral capillary oxygen saturation <93%, and need for oxygen therapy), and mild COVID-19 as all other symptoms. | 2020-06-19 |
| 32540142 | In the context of the novel coronavirus pneumonia, new challenges have arisen for surgeons in terms of ways to effectively treat outpatients, safety of medical staffs in performing surgery treatment, and the lack of efficient postoperative management and follow-up procedure. […] It is hoped that through this article, surgeons will have a better system in hepatobiliary diseases classification, treatment selection, and protective measures to improve the clinical practice in accordance with the guidelines for the diagnosis and treatment of the novel coronavirus pneumonia. | 2020-06-19 |
| 32540201 | Severe traumatic brain injury (TBI), as one of critical conditions in the department of neurosurgery, requires an early and effective treatment, especially surgery. […] According to the corresponding treatment regulations and guidelines issued by the authorities, we summarized the management strategy of TBI patients in perioperative period during the COVID-19 outbreak based on medical and nursing practice, in order to provide a reference for clinicians. | 2020-06-19 |
| 32540204 | None of the treatment given in the previous month (including cytotoxics, PD1 Ab, anti-CD20, VEGFR2…) correlated with survival. | 2020-06-19 |
| 32540264 | Previous studies have paid more attention to the epidemic situation of COVID-19 and patient diagnosis and treatment. | 2020-06-19 |
| 32540267 | To propose, based on expert advice and current evidence where available, a strategy to reorganize female and functional urological (FFU) activity (diagnosis and treatment). […] In all the treatment schemes proposed in the literature on the COVID-19 pandemic, FFU surgery is not adequately covered and usually grouped into the category that is not urgent or can be delayed, but in a sustained pandemic scenario there are cases that cannot be delayed that should be considered for surgery as a priority. […] Many patients will suffer delays in urology treatment because of COVID-19, with consequent impairment of their physical and psychological health and deterioration of their quality of life. | 2020-06-19 |
| 32540268 | Amid the coronavirus disease 2019 (COVID-19) pandemic, patients diagnosed with renal cell carcinoma and infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) may receive complimentary treatment modalities to enhance therapeutic response. | 2020-06-19 |
| 32540345 | Among the various treatment proposals for COVID-19 infection, passive immunotherapy using plasma from recovering patients - “convalescent plasma” (CP)- could be a promising option in the treatment of SARS-CoV-2 infections. […] According to the World Health Organization (WHO), the use of plasma therapy is permitted when faced with «serious diseases for which there are no effective pharmacological treatments». […] The Food and Drug Administration (FDA), the U.S. regulatory authority, has approved the use of CP for compassionate use in the treatment of patients with a critical COVID-19 infection. […] Below are the general indications for drawing up clinical protocols for the integral management of “COVID-19-convalescent plasma” for which the validation and approval of the Ethics Committees is still necessary. | 2020-06-19 |
| 32540367 | As a consequence, there is an unprecedented urgency for researchers and scientific committees from all over the world to find an effective treatment and vaccine. […] The crucial issue is now clearly to find the suitable treatment strategy for patients given comorbidities and the timeline of the illness. […] In light of pathogenesis and proposed clinical classification, this review’s purpose is to summarize and simplify the most important updates on the management and the potential treatment of this emergent disease. | 2020-06-19 |
| 32540370 | Investigation of clinical characteristics and outcomes of severe cases of COVID-19 will contribute to early prediction, accurate diagnosis, and treatment to improve the prognosis of patients with severe illness. | 2020-06-19 |
| 32540428 | The COVID-19 pandemic, caused by the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), is a current global threat for which there is an urgent need to search for an effective therapy. […] Hence, it is worth further exploring eltrombopag as a potential drug for the treatment of SARS-CoV-2 infection. | 2020-06-28 |
| 32540603 | The rheological, anti-inflammatory, and renin-angiotensin axis properties of PTX highlight this drug as a therapeutic treatment alternative for patients with COVID-19 by helping reduce the production of the inflammatory cytokines without deleterious effects on the immune system to delay viral clearance. […] Therefore, we propose repositioning PTX in the treatment of COVID-19. | 2020-06-26 |
| 32540605 | Hence, every branch of Medicine, even though not directly involved in the treatment, has been called upon to provide its contribution to resolve the crisis. | 2020-06-26 |
| 32540733 | The proposed drugs that are in clinical trial for COVID-19 treatment must be carefully considered for clinical use, especially in patients with MS. […] The drugs currently evaluated for the infection treatment are promising but need further studies to prove their efficacy and safety, due to the adverse effects may be exacerbated by combination therapy or due to viral infection. | 2020-06-26 |
| 32540737 | There is an urgent need to assess clinically relevant outcomes in people with diabetes and COVID-19 based upon baseline antidiabetes therapy, in particular pioglitazone. | 2020-06-26 |
| 32540749 | The COVID-19 pandemic has brought major challenges to healthcare systems and public health policies globally, as it requires novel treatment and prevention strategies to adapt for the impact of the pandemic. […] Moreover, social and economic changes caused by the pandemic, along with the traditional difficulties regarding treatment access and adherence-will certainly worsen during this period, therefore aggravate their condition. […] In that sense, specific strategies for prevention and treatment must be discussed. health care professionals dealing with SUD must be aware of the risks and challenges they will meet during and after the COVID-19 outbreak. | 2020-06-27 |
| 32540837 | Comprehensive analysis using the following parameters were performed, Age, Sex, Ethnicity, Body Mass Index (BMI), Comorbidities, Inflammatory markers, Laboratory values, cardiac and renal function, electrocardiogram (EKG), Chest x ray findings, temperature, treatment groups, hospital acquired SARS-CoV-2 patients. | 2020-06-16 |
| 32540850 | The potential immune intersection between COVID-19 disease and cancer therapy raises important practical clinical questions and highlights multiple scientific gaps to be filled. […] Among available therapeutic approaches to consider, checkpoint inhibitors (ICI) seem to require major attention as they may act at the cross-road between cancer treatment and COVID-19 disease, due to their profound immunomodulatory activity. […] Comprehensively, though with the necessary caution, ICI therapy seems to remain a suitable therapeutic option for cancer patients during the COVID-19 pandemic. | 2020-06-16 |
| 32540883 | Increasing appreciation of this by clinicians will ensure earlier diagnosis, monitoring and treatment of patients presenting with this. | 2020-06-23 |
| 32540901 | Based on these criteria, we selected pairs of highly-potent individual antibodies that simultaneously bind the receptor-binding domain of the spike protein, providing ideal partners for a therapeutic antibody cocktail that aims to decrease the potential for virus escape mutants that might arise in response to selective pressure from a single antibody treatment. | 2020-06-16 |
| 32540902 | In addition to providing guidance for vaccine design, the antibodies described here are promising candidates for COVID-19 treatment and prevention. | 2020-06-16 |
| 32540903 | The study suggests a role for nAbs in prophylaxis, and potentially therapy, of COVID-19. | 2020-06-19 |
| 32540904 | Importantly, escape mutants were not generated following treatment with a non-competing antibody cocktail. | 2020-06-16 |
| 32541085 | To date, no medication supported by randomized clinical trials has been approved for the treatment of COVID-19. […] Authors describe a case and review recent knowledge on the treatment of COVID-19. | 2020-06-17 |
| 32541352 | This analysis extrapolates information from prior studies and experiences to bring PM&R perspective and intervention to the multidisciplinary treatment of COVID-19. […] Pulmonary rehabilitation during the acute management of COVID-19 should be considered when possible and safe and may include nutrition, airway, posture, clearance technique, oxygen supplementation, breathing exercises, stretching, manual therapy, and physical activity. | 2020-06-16 |
| 32541471 | Treatment of COVID-19 especially in solid organ transplant recipients is empirical and controversial, especially the adjustment of the immunosuppressants. | 2020-06-22 |
| 32541475 | Currently, the global number of infected novel coronavirus has exceeded 2.6 million and the death toll has exceeded 170,000, but the specific drug for the treatment of COVID-19 has been not appears. […] In the process of fighting COVID-19 in China, JHQG has been promoted by the Chinese government and widely used in the treatment of COVID-19. | 2020-06-22 |
| 32541495 | The conclusion of this study will provide evidence to determine whether Jinhua Qinggan granules is an effective treatment for COVID-19. | 2020-06-22 |
| 32541496 | We aim to assess the efficacy and safety of Chinese medicine in treatment of coronavirus-related pneumonia with the updated results of relevant clinical trials. […] The second outcomes include the length of stay in hospital and intensive care units, the duration of mechanical ventilation, and adverse events. […] The evidence to date of Chinese medicine in treatment of coronavirus-related pneumonia will be systematically reviewed and meta-analyzed. | 2020-06-17 |
| 32541844 | Care providers from neonatal intensive care units on six continents exchanged and compared protocols on the management of neonates born to SARS-CoV-2-positive mothers. | 2020-06-25 |
| 32541865 | Overall, the compounds identified herein provide promising starting points for the further development of SARS-CoV-2 therapeutics. | 2020-06-27 |
| 32541971 | To explore the infection prevention and control strategy of bedside blood purification treatment in corona virus disease 2019 (COVID-19) isolation ward, and to evaluate the effect of infection prevention and control management measures. […] We summarized and analyzed the clinical features, infection status, outcome and infection prevention and control measures of bedside blood purification treatment patients in COVID-19 isolation ward from February 8, 2020 to March 31, 2020, analyzed the COVID-19 cross-infection between the patients and medical staffs, and the blood-borne pathogens cross-infection situation between the patients, and analyzed the effect of bundle prevention and control measures in controlling the occurrence and spread of cross-infection. […] A total of 101 COVID-19 patients were hospitalized in this COVID-19 isolation ward, of whom 10 patients (9.90%) received bedside blood purification treatment and the blood purification treatment method was continuous hemodialysis filtration (CVVHDF), and the 10 patients received 79 times of blood purification treatment in total. […] Bedside blood purification treatment in the COVID-19 isolation ward, the occurrence and spread of healthcare associated infection can be effectively controlled through effective infection prevention and control management, including divisional isolation, patient behavior isolation and patient placement, operator personal protection and hand hygiene, dialysis waste fluid disposal, isolation room’s air purification, object surfaces, medical devices and medical fabrics disinfection, which can provide experience for diagnosis, treatment and prevention and control of patients in the respiratory infectious disease ward. | 2020-06-17 |
| 32542111 | Clozapine is the only available treatment for refractory schizophrenia but its use involves frequent physical contact with healthcare workers for the purpose of mandatory blood monitoring. | 2020-06-17 |
| 32542131 | Furthermore, disease management has been challenging for the clinicians and other medical personnel in terms of treatment options and availability of personal protective equipment. […] The use of convalescent serum has also shown some interim benefit until a definitive treatment and preventive options are uncovered, such as vaccines and other effective treatment regimens. | 2020-06-17 |
| 32542159 | Given the patient’s lack of respiratory symptoms, diagnosis and treatment were ultimately delayed. […] During this global health crisis, an improved understanding of the various presentations of COVID-19 is paramount in an effort to initiate immediate treatment and prevent further transmission. | 2020-06-17 |
| 32542180 | There is a clear disparity that is represented within the public county health systems, which leads to a widening gap between those who receive adequate treatment for mental illness and those who do not. | 2020-06-17 |
| 32542185 | The current project provides a novel tool for biological studies that can contribute to breakthroughs in coronavirus diagnosis, treatment, and prevention. | 2020-06-17 |
| 32542210 | As a few drugs targeting contact activation are already in clinical development, immediate clinical trials for their use in patients with COVID-19 are potentially feasible for the prevention or treatment of respiratory distress. | 2020-06-17 |
| 32542213 | There are animal data and a previous human trial demonstrating a survival advantage with fibrinolytic therapy to treat acute respiratory distress syndrome. | 2020-06-17 |
| 32542349 | Both the research and policy recommendations included in this commentary emphasize equity-driven: (1) research practices, including applying a social determinants and health equity lens on monitoring, evaluation, and clinical trials activities on COVID-19; and (2) policy actions, such as dedicating resources to prioritize high-risk communities for testing, treatment, and prevention approaches and implementing organizational, institutional, and legislative policies that address the social and economic barriers to overall well-being that these populations face during a pandemic. | 2020-06-16 |
| 32542396 | A competitive inhibition therapy could therefore be developed, using sEVs from engineered mesenchymal stromal/stem cells (MSCs), overexpressing ACE2. | 2020-06-23 |
| 32542464 | Review 1: we synthesized results from randomized-controlled trials (RCTs) comparing HFNC to conventional oxygen therapy (COT) in critically ill patients with acute hypoxemic respiratory failure. […] Review 1: 12 RCTs (n = 1,989 patients) provided low-certainty evidence that HFNC may reduce invasive ventilation (relative risk [RR], 0.85; 95% confidence interval [CI], 0.74 to 0.99) and escalation of oxygen therapy (RR, 0.71; 95% CI, 0.51 to 0.98) in patients with respiratory failure. […] High-flow nasal cannula may reduce the need for invasive ventilation and escalation of therapy compared with COT in COVID-19 patients with acute hypoxemic respiratory failure. | 2020-06-19 |
| 32542571 | Thus, concerns about the reducing and management of COVID-19 are on the rise, as there is need to provide diagnosis, treatment, monitoring, and follow-ups during the pandemic. […] Medical centers are now responding to COVID-19 through rapid adoption of digital tools and technologies such as telemedicine and virtual care which refer to the delivery of healthcare services digital or at a distance using Information and Communications Technology (ICT) for treatment of patients. […] Accordingly, a rapid literature review was conducted, and 35 research studies published from 2019 to May 2020 were employed to provide theoretical and practical evidence on the significance of using telemedicine and virtual care for remote treatment of patients during the COVID-19 pandemic. | 2020-06-23 |
| 32542637 | Patients in inpatient or outpatient psychiatric treatment received a questionnaire, examining psychological distress and psychiatric care during the COVID-19 pandemic. | 2020-06-16 |
| 32542750 | Effect of antiviral therapy was evaluated observationally and fecal viral excretion times among groups with different antiviral regiments were compared with Kaplan Meier plot. | 2020-06-16 |
| 32542785 | Agents that inhibit components of the pro-inflammatory cascade have garnered interest as potential treatment options with hopes that dampening the pro-inflammatory process may improve clinical outcomes. | 2020-06-16 |
| 32542838 | Because of the rapid worldwide propagation of COVID-19 (coronavirus disease 2019), each health care system had to urgently adapt with all efforts aimed to maximize the capacity of treatment for infected patients. […] With this in mind, the President of the French Republic declared on March 12, 2020: “Non-essential hospital care will be postponed, i.e. surgical procedures that are not urgent.” But, in spite of the effort deployed by each hospital to provide a sufficient capacity of treatment for patients requiring a surgical procedure as an emergency, we have observed that the management of these patients have been largely affected, not because of a lack of resources but because of a surprising lack of patients. | 2020-06-16 |
| 32542847 | Use of convalescent plasma for Coronavirus disease 2019 (COVID-19) treatment has gained interest worldwide. […] Gaps in knowledge were identified in the following main domains: study design, patient eligibility, CCP dose, frequency and timing of CCP administration, parameters to assess response to CCP treatment and long-term outcome, adverse events, and CCP application in less resourced countries as well as in paediatrics and neonates. | 2020-06-16 |
| 32542914 | Although far from conclusive and limited by the small sample size and selection bias, these cases demonstrate mild and self-limited disease despite immunosuppressive therapy and various comorbidities that are expected to increase the severity of the clinical picture based on extrapolation from the adult experience with this novel disease. | 2020-06-28 |
| 32542964 | The recent outbreak of Corona Virus disease 19 (COVID-19) highlighted the urgent need for effective treatment, and initiated rapid search for therapies, able to counter the most severe disease effects. […] There is no available specific antiviral treatment of this disease, therefore repurposing of drugs already available for the treatment of other viral and autoimmune diseases has been a part of research efforts. […] Well known anti-inflammatory properties of Chloroquine and Hydroxychloroquine, agents widely used in dermatology, made them potential candidates for the treatment of COVID-19. […] We review pathogenesis and clinical characteristic of COVID-19, as well as treatment options that have been under evaluation in past several months. | 2020-06-16 |
| 32543164 | This study aims to compare the effectiveness of LINCOCIN® and AZITRO® in the treatment of COVID-19 associated pneumonia. […] The patients were divided into LINCOCIN® and AZITRO® treatment groups. […] Bronchoalveolar-lavage PCR results were compared after treatment. […] On the 6th day after starting treatment, negative bronchoalveolar PCR result was 83.3% in the LINCOCIN® group and 33.3% in the AZITRO® group. […] LINCOCIN® usage may be more appropriate in the treatment of COVID-19 associated pneumonia. | 2020-06-19 |
| 32543176 | The available hospital bed for COVID-19 treatment per capita (1.17 × 10-3) in Wuhan was adopted as a reference for manageable risk. | 2020-06-26 |
| 32543196 | Currently, there is no specific anti-SARS-CoV-2 medication. | 2020-06-26 |
| 32543702 | Demographic data, underlying comorbidities, clinical presentation, complications, treatment, and outcomes were collected. | 2020-06-24 |
| 32543802 | Important perioperative management recommendations during this outbreak are emphasized, in addition to discussion of current treatment techniques and strategies available in the battle against COVID-19. | 2020-06-25 |
| 32544034 | Inclusion criteria were: (i) positive nasopharyngeal or lower respiratory tract reverse transcriptase-polymerase chain reaction assays; (ii) severe COVID infection defined as requirement for hospitalization and oxygen therapy; (iii) neurologic manifestations; (iv) abnormal brain MRI. […] A majority of patients (20/37, 54%) had intracerebral hemorrhagic lesions with a more severe clinical presentation: higher admission rate in intensive care units, 20/20 patients, 100% versus 12/17 patients, 71%, p=0.01; development of the acute respiratory distress syndrome in 20/20 patients, 100% versus 11/17 patients, 65%, p=0.005. | 2020-06-23 |
| 32544150 | The current COVID-19 pandemic has the potential to overwhelm the capacity of hospitals and Intensive Care Units in Chile and Latin America. | 2020-06-22 |
| 32544155 | Clinical and epidemiological characteristics were analyzed on the basis of demographic data, medical history, laboratory tests, radiological findings, and treatment information. […] Lesions in lobules still existed in 24 (among 32 patients with lesions; 75%) patients that were discharged, although the main symptoms disappeared a few days after treatment. | 2020-06-25 |
| 32544294 | Immunosuppressive or cytotoxic treatment within 3 months of the diagnosis of SARS-CoV-2 infection was associated with a significantly higher preliminary Case Fatality Rate (pCFR) of 70%, compared with 28% in those not on active treatment (P = 0.0013, 2 proportions z-test). | 2020-06-16 |
| 32544304 | As with previous novel infection outbreaks, antiretrovirals are just one drug class that has been held up as a potential strategy for prophylaxis and treatment with scant evidence and risk of harm. | 2020-06-16 |
| 32544372 | These VH domains may have potential applications for prophylaxis and therapy of COVID-19 alone or in combination, as well as for diagnosis and as tools for research. | 2020-06-26 |
| 32544615 | There is currently no vaccine or specific antiviral treatment existing for COVID-19 virus infection. […] Exosome-based strategies for the treatment of COVID-19 virus infection may include following items: inhibition of exosome biogenesis and uptake, exosome-therapy, exosome-based drug delivery system, and exosome-based vaccine. | 2020-06-28 |
| 32544647 | In the setting of the COVID-19 pandemic, new strategies are needed to address the unique and significant palliative care (PC) needs of patients with COVID-19 and their families, particularly when health systems are stressed by patient surges. | 2020-06-27 |
| 32544648 | Over the course of March and April 2020, New York City experienced a surge of a hundred and seventy thousand COVID-19 cases, overwhelming hospital systems and leading to an unprecedented need for palliative care services. […] To present a model for rapid palliative care workforce expansion under crisis conditions, utilizing supervised advanced psychiatry trainees to provide primary palliative services in the acute care and emergency setting. […] In response to the New York City COVID-19 surge, advanced psychiatry trainees at New York-Presbyterian Columbia University Irving Medical Center were rapidly trained and redeployed to a newly formed psychiatry-palliative care liaison team. […] Under the supervision of consultation-liaison psychiatrists (who also served as team coordinators), these trainees provided circumscribed palliative care services to patients and/or their families, including goals of care discussions and psychosocial support. […] Palliative care attendings remained available to all team members for more advanced, specialized supervision. […] The psychiatry-palliative care liaison team effectively provided palliative care services during the early phase and peak of New York City’s COVID-19 crisis, managing up to 16 new cases per day and provided longitudinal follow-up, thereby enabling palliative care specialists to focus on providing services requiring specialist-level palliative care expertise. […] By training and supervising psychiatrists and advanced psychiatry trainees in specific palliative care roles, palliative care teams could more effectively meet markedly increased service needs of varying complexity during the COVID-19 crisis. […] As new geographic regions experience possible COVID-19 surges in the coming months, this may serve as a model for rapidly increasing palliative care workforce. | 2020-06-27 |
| 32544670 | However, the risk associated with mild and moderate illness from Covid-19 is unknown, and there is no current recommendation for prophylaxis against thromboembolism in patients after hospital treatment unless there are established thrombophilic risk factors. | 2020-06-19 |
| 32544799 | Herein, we report the biological rationale of immune-activating drugs and a brief summary of literature data on the potential therapeutic value of immune checkpoint inhibitors that have been recently tested beyond cancer treatment for their potential to restore cellular immunocompetence. | 2020-06-26 |
| 32544802 | It is reasonable to think that cancer patients undergoing chemotherapy, targeted therapy or immunotherapy could have a more aggressive course if positive for Coronavirus disease CoV-2 (COVID- 19). […] We conducted a literature review on https://www.ncbi.nlm.nih.gov/pubmed/, https://scholar.google.com, www.arxiv.org, www.biorxiv.org, of all articles published using the keywords COVID-19 therapy or treatment and cancer until May 2, 2020. | 2020-06-25 |
| 32544867 | All patients received conventional therapy including Hydroxychloroquine, and lopinavir/ritonavir. | 2020-06-23 |
| 32544879 | Considerations include the infective risk of patients who are inherently immunosuppressed from their malignancy and therapies, long-term oncological outcomes from the treatment decisions undertaken during this extraordinary period, and diverted healthcare resources to support a coordinated whole-of-society outbreak response. | 2020-06-16 |
| 32545171 | Antimicrobial photodynamic therapy (aPDT), using well known, safe and cost-effective photosensitizers, such as phenothiazines, e.g., methylene blue (MB), or porphyrins, e.g., protoporphyrin-IX (PP-IX), might help to mitigate the COVID-19 either to prevent infections or to develop photoactive fabrics (e.g., masks, suits, gloves) to disinfect surfaces, air and wastewater, under artificial light and/or natural sunlight. | 2020-06-17 |
| 32545224 | Currently, there is no vaccine or treatment, and researchers around the world are attempting to fight the infection. | 2020-06-17 |
| 32545240 | Older age or last academic years, being men, and being able to pay for medication were associated with lower FCoV-19S scores. | 2020-06-25 |
| 32545268 | Here, we report on flavonoid phytomedicines with potential for development into prophylactics or therapeutics against coronavirus disease 2019 (COVID-19). | 2020-06-24 |
| 32545409 | These malignancies develop in critical areas for eating, talking, and breathing and are associated with substantial morbidity and mortality despite advances in treatment. […] Additionally, the recent Coronavirus Disease 2019 (COVID-19) pandemic has necessitated adaptations to head and neck cancer care to accommodate the mitigation of COVID-19 risk and ensure timely treatment. […] Then, this review summarizes emerging developments in immunotherapy, radiation therapy, cancer survivorship, and the delivery of care during the COVID-19 era. | 2020-06-19 |
| 32545556 | According to specialists from the Chinese Medical Association for Parenteral and Enteral Nutrition (CSPEN), these activities are crucial for both the therapy success and reduction of mortality rates. […] Nutritional approach should be an inseparable element of therapy in patients with COVID-19. | 2020-06-24 |
| 32545647 | It is important to examine how these factors may be implicated in COVID-19 onset, treatment, and outcomes. | 2020-06-19 |
| 32545714 | There is no vaccine or specific antiviral treatment for COVID-19, which is causing a global pandemic. […] Without this understanding, it is challenging to discover a successful treatment to be approved for clinical use. […] We also identify a class of potent drugs for effective treatment of invading pathogens such as HIV and SARS-CoV-2 (COVID-19), cancer and other diseases, and provide a molecular mechanism of action of the drugs or candidates. | 2020-06-26 |
| 32545799 | Convalescent sera and safe-in-man broad-spectrum antivirals (BSAAs) are readily available treatment options. […] We identified the most potent sera from recovered patients for the treatment of SARS-CoV-2-infected patients. | 2020-06-19 |
| 32546029 | Tocilizumab and lenzilumab are recombinant monoclonal antibodies against IL-6 and granulocyte macrophage colony-stimulating factor, respectively, and have been proposed as a potential treatment for acute, hypoxic respiratory failure associated with COVID-19. Results & methodology: We present the case of a 68-year-old man with COVID-19 who was initially treated with hydroxychloroquine and lenzilumab, but continued to develop hypoxemia, requiring an increase in respiratory support with an associated rise in serum inflammatory markers. […] He was subsequently treated with tocilizumab with marked clinical improvement and a decrease in acute phase reactants within 48 h. Discussion & conclusion: This case demonstrates the effective use of tocilizumab in the treatment of COVID-19 and suggests the superiority of tocilizumab over lenzilumab in the management of this cytokine-mediated syndrome. | 2020-06-27 |
| 32546234 | Allergy and asthma are the most prevalent chronic disorders in children and adolescents, so they need careful attention and, if necessary, an adaptation of their regular treatment plans. | 2020-06-19 |
| 32546446 | Since the beginning of the COVID-19 pandemic, researchers have focused on repurposing of existing antibiotics, antivirals and anti-inflammatory drugs to find an effective therapy. […] Based on their potential antiviral activity and immunomodulatory properties, the favorable pharmacokinetics and safety profile, we propose the use of respiratory fluoroquinolones as adjuncts in the treatment of SARS-CoV-2 associated pneumonia. | 2020-06-19 |
| 32546449 | Some of the novel legal extensions aimed at aiding overloaded healthcare systems are as follows: authorisation to prepare hand and surface disinfectants, eligibility to renew chronic treatment prescriptions, as well as filling pro auctore and pro familia prescriptions by pharmacists, performing COVID-19, influenza, and Group A Streptococcus screening tests, and vaccine administration. | 2020-06-19 |
| 32546453 | In India, the Covid-19 pandemic has thrown open challenges on multiple fronts: (a) the reconfiguration of care in hospitals, in response to Covid-19, has led to many patients suffering non-Covid conditions having to delay their treatment, and (b) the lockdown which though necessary has affected people unequally, some being much worse-off than others. | 2020-06-17 |
| 32546457 | Currently, in the absence of proven therapies, empirical evidence is being used for treatment of Covid-19 disease. […] In the ethics context and in the interest of the larger public good, we suggest the inclusion of simple and safe measures from AYUSH systems in the integrative protocols for prophylaxis and treatment of Covid-19. | 2020-06-17 |
| 32546557 | Sputum was positive for SARS-CoV-2 by PCR, and culture grew Yersinia enterocolitica He recovered following supportive management and treatment with piperacillin-tazobactam. | 2020-06-23 |
| 32546559 | The challenges of the COVID-19 pandemic for UK community palliative care has stimulated rapid innovation in AP. | 2020-06-17 |
| 32546589 | Since the COVID-19 outbreak, Wuhan has adopted three methods of admitting patients for treatment: designated hospitals, newly built temporary hospitals and Fangcang shelter hospitals. […] It has been proven that converting large-scale public venues such as stadiums and exhibition centres into Fangcang shelter hospitals, which serve as hospitals for isolation, treatment and disease monitoring of patients with mild symptoms, is the most effective way to control virus transmission and reduce mortality. | 2020-06-25 |
| 32546635 | Invitations for this survey were sent out as a collaborative effort of the European Society of Minimally Invasive Neurological Therapy (ESMINT), the Society of NeuroInterventional Surgery (SNIS), the Sociedad Iberolatinoamericana de Neuroradiologia Diagnostica y Terapeutica (SILAN), the Society of Vascular and Interventional Neurology (SVIN), and the World Federation of Interventional and Therapeutic Neuroradiology (WFITN). | 2020-06-27 |
| 32546849 | Our newly optimized protocol should be helpful for the large-scale, high-fidelity screening of asymptomatic people, even without any high-specification equipment, for the further prevention of transmission, and to achieve early intervention and treatment for the rapidly propagating virus. | 2020-06-19 |
| 32546882 | Since the disease does not currently have a particular treatment, there is a compelling need to find substitute means to dominate its expansion. | 2020-06-19 |
| 32547039 | With the rise of COVID-19 in China and worldwide, further prevention, diagnosis, and treatment measures are a critical unmet need. | 2020-06-19 |
| 32547222 | To prevent further spread of the disease, restrictions of population flow from the government and measures to reduce virus transmission from hospitals may lead to the delay of diagnosis and treatment in patients with nasopharyngeal carcinoma (NPC). […] The waiting intervals of each step and variation from the diagnosis and treatment path of NPC between two groups were compared. […] During the waiting period of radiotherapy, 32.4% of the NPC patients received an additional one cycle of chemotherapy to the original treatment strategy. […] The prevalence of COVID-19 caused delay in the diagnosis and treatment of NPC patients to a certain extent. […] Additional chemotherapy could be considered to counteract the effect of treatment delay. […] More specific measures should be taken to balance the risk of delayed diagnosis and treatment of NPC and infection of COVID-19. | 2020-06-19 |
| 32547625 | Numerous clinical trials have been initiated to identify an effective treatment. […] One leading candidate is remdesivir (GS-5734), a broad-spectrum antiviral that was initially developed for the treatment of Ebola virus (EBOV). | 2020-06-19 |
| 32547769 | In the wake of atrocious rise in COVID-19 cases, developed countries are leveraging a range of community pharmacy services with the goal of improving access to essential medication and healthcare services. | 2020-06-19 |
| 32547891 | Considering the fact that miRNA-based therapies have been paid attention, based on the findings of this study, comprehending mode of actions of miRNAs and their possible roles during SARS-CoV-2 infections could create new opportunities for the development and improvement of new therapeutics. | 2020-06-19 |
| 32548163 | As a clinician, mastery of the clinical characteristics, basic diagnosis, and treatment methods of COVID-19 are required to provide help to patients. […] In addition to nasal catheter oxygen inhalation and symptomatic support, antiviral drugs were used throughout the treatment. […] COVID-19 in young adults can be successfully treated with active treatment. […] We report a typical case of COVID-19, analyze its clinical characteristics, summarize its clinical diagnosis and treatment experience, and provide a reference for clinical colleagues. | 2020-06-19 |
| 32548259 | Selectively delivering adenosine and antioxidants together could serve as a novel therapeutic approach for safe treatment of acute paradoxal inflammation. | 2020-06-19 |
| 32548598 | The guidelines are in accordance with the relevant laws and documents from the health administration and range from technical guidelines to advice on how dental treatment should be conducted. | 2020-06-18 |
| 32548599 | Tens of thousands of medical staff throughout the country have since rushed to Wuhan to provide intensive medical treatment. […] This article will offer some suggestions for the prevention, treatment and care of the above-mentioned oral mucosal diseases during the fight against coronavirus 2019, focusing on measures to deal with the oral mucosal damage caused in response to stress. | 2020-06-18 |
| 32548600 | COVID-19 is mainly transmitted through respiratory droplets and close physical contact, so it is challenging to prevent nosocomial infection and possible spread during dental treatment. […] Nosocomial infection prevention and control concepts and measures relating to dental diagnosis and treatment are critically checked in the hospital. | 2020-06-18 |
| 32549025 | He had hypoxic respiratory failure and required oxygen therapy. | 2020-06-25 |
| 32549073 | In the same way, most of the localised PCa patients are suitable for active surveillance (AS) or hormonal therapy until local definitive treatment could be reconsidered. […] In metastatic as well as castration resistant PCa stages, adding androgen receptor targeted agents (abiraterone, apalutamide, darolutamide or enzalutamide) to androgen-deprivation therapy (ADT) could be considered in high risk patients. […] ADT allows us to defer definitive local treatment in many cases of intermediate and high risk PCa. | 2020-06-17 |
| 32549074 | We aim to summarise updates on diagnosis, treatment and follow up of bladder cancer during the COVID-19 outbreaks. | 2020-06-17 |
| 32549075 | Recently the COVID-19 pandemic became the main global priority; main efforts and health infrastructures have been prioritized in favor of COVID-19 battle and the treatment of benign diseases has been postponed. […] After a literature review focused in COVID-19 and current RCC treatments, we suggest therapeutic strategies of RCC in two sections: surgical approach and systemic therapy, in all stages of this malignance. […] Upfront cytoreduction, is not recommendable for low risk oligometastatic patients, which must start systemic treatment or even could be put under surveillance and delayed therapy. […] Intermediate and poor risk metastatic patients must start target therapy and/or immunotherapy (few good responders intermediate cases can have postponed cytoreduction). | 2020-06-17 |
| 32549076 | To date there is no study that demonstrates or can suggest the ability for a virus to be transmitted during surgical treatment whether open, laparoscopic or robotic. | 2020-06-17 |
| 32549077 | A non-systematic review of available literature on the management of urological malignancies during the COVID-19 pandemic was performed to summarize recommendations to improve the diagnosis and treatment of urological cancers during and after the contingence, including clinical and research aspects. […] For proper patient management, multidisciplinary approach is encouraged tailoring therapy according to COVID-19 regional behavior and local institutional resources. | 2020-06-17 |
| 32549125 | We highlight that immunomodulatory treatment must be tailored to the underlying immunobiology at different stages of disease. | 2020-06-18 |
| 32549293 | QT prolongation and TdP are most relevant to the COVID-19 treatment regimen of high doses for a comparatively short period and represent the most common HCQ-associated AEs. […] These findings highlight the urgent need for prospective, randomized, controlled studies to assess the risk/benefit ratio of HCQ in the COVID-19 setting before its widespread adoption as therapy. | 2020-06-18 |
| 32549297 | This review also reports the rationale for a possible use of drugs commonly employed in neoplastic therapy, such as bevacizumab, ibrutinib, selinexor, thalidomide, carfilzomib, and PD-1 inhibitors, for the treatment of SARS-CoV-2 infection. | 2020-06-18 |
| 32549298 | Meticulous adherence to rules among patients and personnel and collaboration between leadership and medical staff in order to continue to perform multidisciplinary treatment protocols, maintain the availability of infrastructural spaces and source protective equipment, swabs and screening samples have been successful in the aim towards a safe cure for cancer patients. | 2020-06-18 |
| 32549531 | Despite a strong pathophysiological rationale, the evidences in literature are not enough to recommend an aggressive antithrombotic therapy in COVID- 19. | 2020-06-18 |
| 32549692 | There has been limited information available on the presenting characteristics and outcomes of COVID-positive patients with hip fractures who undergo surgical treatment. […] This was a retrospective study of 10 patients ≥60 years of age with a hip fracture and COVID-19 who underwent surgical treatment in New York City during the COVID-19 outbreak from March 1, 2020 to May 22, 2020. […] Two patients had persistently elevated oxygen demands requiring prolonged administration of supplemental oxygen therapy beyond postoperative day 3. | 2020-06-19 |
| 32549989 | Earlier publications worldwide demonstrate higher mortality among patients receiving mechanical ventilation in intensive care units during “surges” in the number of cases. | 2020-06-19 |
| 32550035 | 0.1 g bid Quetiapine was given orally, then gradually increased to 0.4 g per day, supplemented by cognitive therapy. | 2020-06-19 |
| 32550040 | Human recombinant ACE2 has been considered as a potential therapy for SARS-CoV-2 by blocking virus entry and redressing the imbalance of RAAS in SARS-CoV-2 infection. […] The level of ACE2 expression can be upregulated by treatment with an ACE inhibitor (ACEI) or angiotensin Ⅱ type 1 receptor blocker (ARB). | 2020-06-19 |
| 32550054 | Given the scarcity of resources including healthcare staff, hospital capacities, test kits, etc., timely diagnosis and treatment of this virus are of paramount importance. […] However, there is no vaccination or drug developed for the treatment of this disease up to today. […] Because the spreading rate of the virus is very high worldwide and there is no definitive treatment, diagnosis becomes even more important. | 2020-06-19 |
| 32550056 | We searched using PubMed and Google Scholar using keywords such as COVID-19, coronavirus, and their combination with pathological findings, clinical features, management, and treatment to search for relevant published literature. […] Supportive treatment such as oxygen therapy, extracorporeal membrane oxygenation, and ventilator support can also be used. […] There is no definitive treatment, although a combination of hydroxychloroquine and azithromycin have shown good results, and passive immunization also shows promising results, their safety profile is yet to be studied in detail. | 2020-06-19 |
| 32550069 | New anticoagulant, nafamostat, used in Japan is also discussed as a possible potentiate for heparin therapy. | 2020-06-19 |
| 32550078 | The goal of this technical report is to further encourage the study of heated air as a potential COVID-19 treatment. | 2020-06-19 |
| 32550090 | Demographic, clinical, laboratory, and treatment data were reviewed against periods of bradycardia in each patient. | 2020-06-19 |
| 32550127 | Treatment strategy adopted was supportive and patient improved wit timely symptomatic management. | 2020-06-19 |
| 32550141 | In conclusion, enlarged PA diameter was associated to death in COVID-19 patients, a finding deserving further investigation as a potential driver of therapy decision-making. | 2020-06-19 |
| 32550223 | The pandemic demands action on many fronts, from prevention to testing to treatment. […] It is widely believed that during the pandemic treatment suffers. | 2020-06-19 |
| 32550287 | Acute stroke care demands real-time, specialist-led treatment decisions, including thrombolysis and referral for mechanical thrombectomy. | 2020-06-19 |
| 32550670 | The purpose of this document is to propose technical strategies to assist the pediatric surgeons to minimize the potential aerosolization of viral particles in COVID-19 patients undergoing urgent or emergent surgical treatment using laparoscopic approaches, based on the currently available literature. […] A consensus regarding urgent laparoscopic procedures, setting and operation techniques was obtained within the Committee and the Board. Conclusions: The ESPES proposes the following recommendations in case minimally invasive surgery is needed in a COVID-19 positive pediatric patients: (1) consider conservative treatment whenever safely possible, (2) dedicate a theater, columns and reusable laparoscopic instrumentation to COVID-19 pediatric patients, (3) prefer disposable instrumentation and cables, (4) use low CO2 insufflation pressures, (5) use low power electrocautery, (6) prefer closed-systems CO2 insufflation and desufflation systems, and (7) avoid leaks through ports. | 2020-06-23 |
| 32550701 | Surgical elective treatment of benign prostatic hyperplasia (BPH) is not considered as a priority. | 2020-06-18 |
| 32550705 | From the beginning of the pandemic, several publications and on-line resources about different treatment lines have been done, and development effort in response to the COVID-19 pandemic to investigate potential therapies is unprecedented. […] Unfortunately, until now, there is not enough evidence to recommend any specific anti-COVID19 treatment. | 2020-06-18 |
| 32550706 | Responsible use of these tools can help quickly disseminate important new information, relevant new scientific findings, share diagnostic, treatment, and follow-up protocols, as well as compare different approaches globally, removing geographic boundaries for the first time in history. | 2020-06-18 |
| 32551214 | Early diagnosis and surgical therapy are critical in patients with gangrenous cholecystitis. | 2020-06-20 |
| 32551560 | These aptamers present an opportunity for generating new probes for recognition of SARS-CoV-2, and could provide assistance in the diagnosis and treatment of SARS-CoV-2 while providing a new tool for in-depth study of the mechanisms behind the coronavirus infection. | 2020-06-19 |
| 32551639 | In the current situation, the virus is rapidly spreading worldwide, and the discovery of a vaccine and potential therapeutics are critically essential. | 2020-06-22 |
| 32551759 | While the United States has acted to improve access to treatment for mental health and opioid use, research will be needed to understand the effectiveness of new policies in the context of COVID-19. | 2020-06-23 |
| 32551760 | This strategy has inhibited treatment and care for certain groups of people who are not COVID-19 patients. | 2020-06-19 |
| 32551771 | The authors encourage specific therapeutic considerations and offer suggestions for adapting treatment with regard to these early observations. | 2020-06-19 |
| 32551775 | Trauma-informed guilt reduction therapy is a brief intervention that helps clients accurately appraise their role in a stressful event (such as those experienced during the COVID-19 pandemic) and find positive ways to express important values going forward. […] Future studies of trauma-informed guilt reduction therapy with those affected by COVID-19 will be helpful for clarifying its effectiveness with this population. | 2020-06-19 |
| 32551777 | Older adults’ struggles with loneliness, fear of dying, and the sequelae of untreated medical conditions are viewed through the lens of anticipatory grief, and coping and treatment strategies are offered. | 2020-06-25 |
| 32551792 | The concerted efforts of Chinese scientists led to the independent isolation from patients and identification of a novel coronavirus, SARS coronavirus 2 (SARS-CoV-2), on 6 January 2020; this has been an important step in the development of treatment. […] The purpose of this article is to overview the history, epidemiology, clinical characteristics, diagnosis, and treatment of COVID 2019 reported in recently published studies. | 2020-06-23 |
| 32551814 | Fulminant thrombotic complications emerge as critical issues in patients with severe COVID-19. Objective: To present a review of the literature and discuss the mechanisms of COVID-19 underlying coagulation activation and the implications for anticoagulant and thrombolytic treatment in the management of COVID-19. Data Sources: We performed a systemic review of scientific papers on the topic of COVID-19, online available via the PubMed NCBI, medRxiv, and Preprints as of May 15, 2020. | 2020-06-19 |
| 32551855 | The recent COVID-19 outbreak created an urgent need for treatment. […] To expedite the development of such treatment, pharmaceutical companies and government agencies are currently testing several existing drugs for their effect on the virus. | 2020-06-27 |
| 32552021 | This model illustrates the functions of social media across the epidemic-response continuum, ranging across contagion, vector, surveillance, inoculant, disease control, and treatment.We also describe attributes of the communications, diseases and pathogens, and hosts that influence whether certain functions dominate over others. | 2020-06-19 |
| 32552110 | The coronavirus disease 2019 (COVID-19) pandemic has imposed a unique challenge to oncology patients and their treatment. […] There is no study related to the patients’ preference for systemic therapy during this pandemic. […] Treatment was curative in 150 patients and palliative in 152. […] Knowledge about COVID-19 strongly correlated with intent of treatment (P = .01), disease status (P = .02), knowledge about immunosuppression (P < .001), home location (P = .02), and education status (P = .003). […] The treatment guidelines in the COVID-19 scenario should incorporate patients’ perspectives. | 2020-06-23 |
| 32552178 | Most infected patients who have been admitted to intensive care units show SARS signs. | 2020-06-19 |
| 32552412 | Cardiac rehabilitation (CR) is a class I treatment for cardiovascular disease, however, underutilization of these services remains. | 2020-06-19 |
| 32552462 | Traditional Chinese medicine has recommended the use of liquorice (Glycyrrhiza species) in the treatment of infections caused by SARS-CoV-2. | 2020-06-25 |
| 32552500 | Background: The COVID-19 pandemic has created an environment in which existence is more fragile and existential fears or terror rises in people. Objective: Managing existential terror calls for being mature about mortality, something with which palliative care providers are familiar and in need of greater understanding. Methods: Using a case to illustrate, we describe existential terror, terror management, and existential maturity and go on to outline how existential maturity is important for not only the dying and the grieving but for also those facing risk of acquiring COVID-19. Results: Next, we describe how essential components in attaining existential maturity come together. | 2020-06-19 |
| 32552549 | In this study, we evaluated the heat treatment method without RNA extraction as a reliable option to nucleic acid purification. | 2020-06-24 |
| 32552872 | Continuous renal replacement therapy (CRRT) was required in 5.6% (95% CI 2.6-8.6%) severe patients, 0.1% (95% CI - 0.1-0.2%) non-severe patients and 15.6% (95% CI 10.8-20.5%) non-survivors and 0.4% (95% CI - 0.2-1.0%) survivors, respectively. | 2020-06-22 |
| 32553273 | The development of an accessible mouse model of SARS-CoV-2 infection and pathogenesis will expedite the testing and deployment of therapeutics and vaccines. | 2020-06-22 |
| 32553309 | The TB treatment centres and hospitals needs to be prepared for early diagnosis and management of severe COVID-19 in TB patients. | 2020-06-22 |
| 32553456 | We describe how we have adjusted our current treatment of multiple facets of pediatric surgery including oncology, trauma, minimally invasive procedures, and extracorporeal membrane oxygenation (ECMO). | 2020-06-22 |
| 32553507 | One of the peculiar aspects of the transplant patient’s life is that, in the post-surgery phase, the patient lives in an “isolation” condition, having to pay particular attention to the living environment and preferring a limited social life given that the immunosuppressive treatment entails immunodepression in the patient. […] Transplant patients have faced the measure of social distancing adequately and in adherence to the treatment thanks to the phone assistance of all the medical-surgical and psychological team. | 2020-06-22 |
| 32553516 | COVID-19 pandemic caused not only many deaths around the world but also made evident technical limitations of hospital and intensive care units (ICU). | 2020-06-19 |
| 32553536 | A treatment algorithm that included tocilizumab to target CRS may influence mechanical ventilation and survival outcomes. | 2020-06-19 |
| 32553562 | Up to date, a lot of reports have shown that olfactory dysfunction is related to viral infections but no exact mechanism, clinical course, and definite treatment have been discovered, which is also same in COVID-19. | 2020-06-22 |
| 32553666 | With lack of definitive therapy, patient education, hand hygiene and social distancing appears to be the cornerstone in minimising the disease spread. | 2020-06-22 |
| 32553705 | We aimed to evaluate the perception of this in Celiac Disease (CeD) patients who require a lifelong gluten-free diet as a therapy. | 2020-06-19 |
| 32553772 | The recommendations for those patients, in addition to the general measures of physical distancing and handwashing for all persons, include social, medical, and psychologic support during the period of home quarantine to prevent lapses in treatment. | 2020-06-22 |
| 32553861 | Children with MIS-C admitted to pediatric intensive care units (PICU) in New York City between April 23 and May 23, 2020 were included. […] For treatment, intravenous immunoglobulin was used in 18 (54%), corticosteroids in 17 (51%), tocilizumab in 12 (36%), remdesivir in 7 (21%), vasopressors in 17 (51%), mechanical ventilation in 5 (15%), extracorporeal membrane oxygenation (ECMO) in 1 (3%), and intra-aortic balloon pump in 1 (3%). | 2020-06-22 |
| 32553907 | During the treatment of COVID-19 in chronic HBV-infected patients, liver function should be taken seriously and evaluated frequently. | 2020-06-21 |
| 32553928 | It is urgent to propose new treatment options, which are more effective in the interaction between viruses and cells. | 2020-06-28 |
| 32554043 | This study supported the advantage of the combined method for detection of SARS-COV-2 with a high degree of sensitivity and specificity, as a useful tool for accurate diagnosis and timely treatment of suspected patients, epidemiological investigation, as well as monitoring ongoing outbreaks of infections with SARS-COV-2. | 2020-06-23 |
| 32554284 | We speculate that immune reconstitution induced by treatment may induce positive changes in the immune system in the defense against SARS-CoV2. | 2020-06-26 |
| 32554380 | Given accessibility of methods with demonstrated efficacy in reducing depression and anxiety (e.g., mindfulness meditation and cognitive behavioural therapy [CBT]) and limitations imposed by geographic obstructions and localized expertise, web-based alternatives have become vehicles for scaled-up delivery of benefits at modest cost. […] Mindfulness Virtual Community (MVC), a web-based program informed by cognitive behavioral therapy (CBT) constructs and featuring online videos, discussion forums, and videoconferencing was developed to target depression, anxiety, and experiences of excess stress among university students. […] Assessment of an eight-week web-based mindfulness and cognitive behavioural therapy (CBT) program in reducing symptoms of depression, anxiety, and stress (primary outcomes) and increasing mindfulness (secondary outcome) within a randomized controlled trial (RCT) with undergraduate students at a large Canadian university. | 2020-06-19 |
| 32554697 | New approaches are needed to understand enteric pathogenesis and develop vaccines and therapeutics to prevent the spread of these viruses. | 2020-06-19 |
| 32554825 | In viral pandemics, most specifically Covid-19, many patients with neuroendocrine neoplasms (NENs), including phaeochromocytomas, paragangliomas and medullary thyroid carcinoma, may develop Covid-19 in a mild or severe form, or be concerned about the influence of viral infection relative to their anti-tumoral therapy. […] In general, newly-presenting patients should be assessed, and patients recently receiving chemotherapy, targeted therapy or radionuclide therapy, or showing tumour growth, should be closely followed. […] For previously diagnosed patients, who have indolent disease, some delay in routine follow-up or treatment may not be problematic. […] However, patients developing acute secretory syndromes due to functional neuroendocrine neoplasms (such as of the pancreas, intestine or lung), phaeochromocytomas and paragangliomas, will require prompt treatment. […] In patients with especially aggressive NENs, a careful judgement should be made regarding the severity of any Covid-19 illness, tumour grade, and the immunosuppressant effects of any planned chemotherapy, immunotherapy, targeted therapy or related treatment. | 2020-06-19 |
| 32554861 | All patients received antiviral treatment, including Lopinavir / Ritonavir (29.3%), Interferon (14.6%) and their combination (40.6%), Arbidol (6.7%), Xuebijing (7.1%) and Chloroquine phosphate (1.3%). | 2020-06-19 |
| 32554879 | Historical literature dating back to the 1940s and earlier contains many reports of successful treatment of pneumonias with ionizing radiation. | 2020-06-19 |
| 32554953 | Several anti-viral drugs such as RNA dependent RNA polymerase inhibitors (remdesivir, favipiravir, ribavirin), protease inhibitors (lopinavir, ritonavir) and drugs targeting endocytic pathway (hydroxychloroquine) are being evaluated for COVID-19 but standard therapeutics yet not available. […] To combat cytokine storm, immune-therapy targeting IL-1, IL-2, IL-6 and TNFα are being evaluated and one of the promising immune-modulator is the mesenchymal stem cells (MSCs) that can surmount the severity of COVID-19 infections. […] Recent studies have shown that MSC-therapy significantly dampens the cytokine storm in critically ill COVID-19 patients. […] This communication endows with the insight of stem cell therapy and summarizes the recent studies on COVID-19 patients. | 2020-06-19 |
| 32554959 | Electroconvulsive therapy (ECT) is a critical procedure in psychiatric treatment, but as typically delivered involves the use of bag-mask ventilation (BMV), which during the COVID-19 pandemic exposes patients and treatment staff to potentially infectious aerosols. […] No acute physical, respiratory, or psychiatric complications occurred during treatment. | 2020-06-25 |
| 32555006 | The clinical and imaging data of 64 patients with confirmed diagnoses of COVID-19 were retrospectively selected and divided into a stable group and a progressive group according to the data obtained from the ongoing treatment process. | 2020-06-19 |
| 32555087 | The current surgical gold treatment standard is intramedullary nail fixation. […] Optimum treatment involves rapid execution of surgery, minimal trauma during surgery, maximum mechanical stability, and rapid weight-bearing. | 2020-06-22 |
| 32555446 | In response to this epidemic, China has issued seven trial versions of diagnosis and treatment protocol for COVID-19. […] According to the information that we have collected so far, this article provides an overview of potential therapeutic drugs and compounds with much attention, including favipiravir and hydroxychloroquine, as well as traditional Chinese medicine, which have been reported with good clinical treatment effects. | 2020-06-28 |
| 32555564 | In the present position paper we collected current evidence from the literature to provide practical recommendations on the management of antithrombotic therapies (antiplatelet and anticoagulant) in various clinical contexts prevalent during the SARS-CoV-2 outbreak: in-home management of oral anticoagulant therapy; interactions between drugs used in the SARS-CoV-2 infection and antithrombotic agents; in-hospital management of antithrombotic therapies; diagnosis, risk stratification and treatment of in-hospital thrombotic complications. | 2020-06-19 |
| 32555565 | It seems therefore necessary that patients, especially for time-dependent diseases such as ACS, continue to refer to hospital care; that contemporary standard of care for acute cardiac disease should be guaranteed, and that intensivist cardiologists acquire specific skills for the treatment of patients with clinical conditions normally treated by other specialists. | 2020-06-19 |
| 32555723 | We examined the decision-making impact of these actions and their effects on access to hospital treatment in patients with neurosurgical conditions. […] Spinal or cranial conditions requiring immediate hospital admission and treatment constituted emergencies. | 2020-06-22 |
| 32555949 | Patients undergoing glucocorticoid (GC) replacement therapy for adrenal insufficiency (AI) represent a highly vulnerable group that could develop severe complications due to the SARS-CoV-2 infection. […] Once patients with AI present symptoms of COVID-19, the dose of GC replacement therapy should be immediately doubled. | 2020-06-24 |
| 32555974 | These include chloroquine (CQ), hydroxychloroquine (HCQ), nitazoxanide, remdesivir, Lopinavir/ritonavir (LPV / r), in addition to treatment with convalescent plasma. […] Most of the information obtained about treatment is based on preliminary and limited studies. | 2020-06-19 |
| 32556054 | Researchers globally are dedicating efforts to the search for an effective treatment for COVID-19. | 2020-06-23 |
| 32556143 | After propensity score weighting, treatment with hydroxycholoroquine was not associated with a significantly reduced risk of unfavorable outcome (HR 0.90 [0.38; 2.1], p = 0.81). […] Ongoing controlled trials in patients with varying degrees of initial severity on a larger scale will help determine whether there is a place for hydroxychloroquine in the treatment of Covid-19. | 2020-06-19 |
| 32556147 | Topics addressed include diagnosis, triage, and the fundamental principles of treatment with a focus on the importance of characterizing DKA severity and medical complexity to determine the best approach. […] Evidence for alternative treatment strategies is explored with special attention placed on treatment options that may be more relevant during the pandemic including use of subcutaneous insulin therapy. | 2020-06-19 |
| 32556191 | Testing asymptomatic individuals without known exposure is suggested when the results will impact isolation/quarantine/personal protective equipment (PPE) usage decisions, dictate eligibility for surgery, or inform administration of immunosuppressive therapy. | 2020-06-19 |
| 32556293 | The signature of COVID-19 presents a novel predictor and prognostic biomarker for closely monitoring patients and providing timely treatment for those who are severely or critically ill. | 2020-06-19 |
| 32556323 | The recommendations include safety recommendations, treatment recommendations, discharge recommendations, and staffing recommendations. […] Treatment recommendations address 2 phases of hospitalization: when patients are critically ill and admitted to the ICU, and when patients are severely ill and admitted to the COVID ward. | 2020-06-19 |
| 32556449 | In fact, unlike when using conservative methods for the treatment of protruding ears, this prolonged pressure can increase the cephaloauricular angle of the outer auricle. | 2020-06-22 |
| 32556649 | Although several studies have reported on the clinical and epidemiological characteristics of the patient with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), clinical course of the most severe cases requiring treatment in ICU have been insufficiently reported. […] A 73-year-old man traveling on a cruise ship with history of hypertension and dyslipidemia developed high fever, dyspnea and cough after 7 days of steroid treatment for sudden sensorineural hearing loss, and tested positive for SARS-CoV-2 in sputa polymerase chain reaction (PCR) examination. […] Interferon beta-1b subcutaneous injection was initiated immediately to enhance anti-viral therapy, and favipiravir on ICU day 10 upon availability. […] Progression of organ dysfunctions necessitated inhalation of nitrogen oxide for respiratory dysfunction, noradrenaline for cardiovascular dysfunction and continuous renal replacement therapy for renal dysfunction. | 2020-06-22 |
| 32556781 | These findings may aid future research on the diagnosis, prevention, and treatment of COVID-19 consequences. | 2020-06-22 |
| 32556875 | These studies all included different interventions (thromboprophylaxis with unfractionated heparin (UFH) or low molecular-weight heparin (LMWH); an intensive thromboprophylaxis protocol with LMWH, antithrombin, and clopidogrel; and salvage therapy with tissue plasminogen activator and heparin). […] Prospective trials of antithrombotic treatment strategies among patients with COVID-19 are urgently needed. | 2020-06-22 |
| 32556942 | The innate immune system is therefore a potentially important target for therapeutic treatment of COVID-19, but experimental studies are needed, and SARS-CoV-2 presents unique challenges for pre-clinical and mechanistic studies in vivo. | 2020-06-22 |
| 32557183 | The second aim is to suggest minimally invasive treatment alternatives for caries management, minimising the risk of viral cross-infection and offering a safer clinical environment. […] All guidelines released in response to COVID-19 centred around minimising Aerosol Generating Procedures (AGP) impacting the provision of regular dental treatment of paediatric patients. | 2020-06-22 |
| 32557209 | Hemodialysis therapy was performed in isolation with hydroxychloroquine administration, but the formation of a dialysis membrane clot forced the withdrawal of dialysis therapy. […] Changing the dialysis membrane material and anticoagulant enabled the resumption of dialysis therapy, allowing the body weight to correct downward. | 2020-06-22 |
| 32557214 | As interleukin-6 (IL-6) acts as a key driver of the inflammation associated with coronavirus disease 2019 (COVID-19), IL-6 and IL-6 receptor (IL-6R) inhibition appear to be promising targets for the treatment of COVID-19 patients. | 2020-06-22 |
| 32557271 | Elderly males, especially those affected by previous diseases or with comorbidities, are more prone to develop interstitial pneumonia that can deteriorate evolving to ARDS (acute respiratory distress syndrome) that require hospitalization in Intensive Care Units (ICUs). […] In this review, we suggest that vitamin D supplementation might play a role in the prevention and/or treatment to SARS-CoV-2 infection disease, by modulating the immune response to the virus both in the adult and pediatric population. | 2020-06-22 |
| 32557347 | Hospitalization with supportive therapy (azithromycin) as well as non-invasive oxygenation led to a stabilization of the patient. […] Negative pressure therapy resulted in regression of the pneumothorax and the patient was discharged after 9 days of treatment. | 2020-06-22 |
| 32557405 | Scientists are attempting to investigate antivirals specific to COVID-19 treatment. | 2020-06-22 |
| 32557533 | In British Columbia, the health care system has launched resources to support clinicians in proactive advance care planning discussions, and is providing enhanced supportive and palliative care options to residents of long term care facilities. | 2020-06-19 |
| 32557541 | Given these points, we reviewed the current evidence regarding the potential therapeutic role of tocilizumab and its important clinical issues in the treatment of ARDS related to COVID-19. | 2020-06-19 |
| 32557557 | Here, we argue that the demonstrated anti-inflammatory, pro-resolving, anti-thrombogenic and anti-microbial effects of pro-resolution mediators may be useful in the treatment of the late stages of disease in patients with COVID-19. | 2020-06-19 |
| 32557593 | This has included staffing dramatically expanded intensive care units, redeployment, cross-skilling and embracing new ways of working. | 2020-06-19 |
| 32557596 | Individualizing the management of patients while ensuring their safety and adherence to the study protocol, establishing specific staff contingency plans, and maintaining sponsor and contract research organization (CRO) alignment are some of the key issues for maintaining the continuity of cancer patients’ investigational treatment and minimizing their infection risk as well as the risk to staff members of the unit, sponsors, and CROs while maintaining the integrity of data quality and compliance with good clinical practice. | 2020-06-22 |
| 32557623 | In the present report, we first describe two cases of persisting SARS-CoV-2 viraemia with fatal outcome in patients after rituximab therapy. | 2020-06-22 |
| 32557648 | Scientific simulations and more in-depth data analysis permit to validate or refute drug repurposing opportunities predicted via target similarity profiling to speed up the development of a new more effective anti-2019-nCoV therapy especially where in vitro and/or in vivo data are not yet available. | 2020-06-19 |
| 32557815 | National training on Covid-19 treatment for healthcare professionals across the entire hospital system was useful to expand the health service availability. | 2020-06-19 |
| 32557905 | Research into understanding the pathophysiology behind this virus, to ascertain best medical management and treatment, has been accelerated to keep up with the rapidly evolving situation. | 2020-06-19 |
| 32557972 | Aim of our work is to report organization strategies at a radiation therapy (RT) department in the first European area experiencing the COVID-19 pandemic. […] Median overall treatment time was 50 (interquartile range: 47-54.25) days. | 2020-06-19 |
| 32558015 | Although dermatologic societies recommend the continuing of psoriatic systemic therapies and biologics, little is known about treatment adherence in psoriatic patients during COVID-19 outbreak. […] Medication self-management may feel burdensome to patients with psoriasis due to the nature of treatments and many of them face additional challenges as they may suffer from comorbidities. […] Acknowledging treatment non-adherence as a consequence of conflicting goals may help to find the reasons for but, most important, solutions to non-adherence especially during public health crises. […] The objective of our study was to evaluate the adherence of psoriatic patients in traditional systemic treatment as well as biologics and identify possible influencing factors of drug interruption during COVID-10 pandemic. | 2020-06-19 |
| 32558069 | Several new routines and practices have been proposed to reduce this risk in dental offices, but standard dental treatment is expected to happen only after the “first wave” of disease and on an entirely new basis. | 2020-06-19 |
| 32558150 | Human and mice data analysis further revealed ACE2 expression is reduced in T2D patients and with inflammatory cytokine treatment and upregulated by estrogen and androgen (both decrease with age). […] These results will be instrumental when designing potential prevention and treatment strategies for ACE2 binding coronaviruses in general. | 2020-06-19 |
| 32558193 | Their treatment has been continued as before, after the symptoms improved. […] Discontinuing the treatment in the acute period of COVID and the restart after recovery may prevent severe recurrence in these patients. | 2020-06-19 |
| 32558210 | The lack of elimination was also confirmed by the fact that plasma levels did not change over the 120 min treatment. […] As neither chloroquine nor hydroxychloroquine were removed by the treatment with the Seraph dose adjustments in COVID-19 patients undergoing this treatment are not necessary. | 2020-06-19 |
| 32558354 | In order to reduce peak viral load by more than 2 logs, drug efficacy needs to be greater than 90% if treatment is administered after symptom onset; an efficacy of 60% could be sufficient if treatment is initiated before symptom onset. | 2020-06-19 |
| 32558435 | In the absence of definitive anti-viral therapy, there is considerable interest in mitigating against severe inflammatory reactions in coronavirus disease-2019 (COVID-19) pneumonia to improve survival. […] We highlight how PDE4i could be an overlooked treatment from the rheumatologic and respiratory armamentarium, which has potential beneficial immune-modulation for treating severe COVID-19 pneumonia associated with cytokine storms. | 2020-06-19 |
| 32558922 | After long term hospitalization or ICU treatment, COVID-19 patients are severe functionally impaired. […] In this article we present a patient centered model to tailor treatment in the view of the Dutch health care system. […] This model can be helpful to determine the appropriate treatment for each patient at the right time in the right setting. | 2020-06-19 |
| 32558945 | Demographic information, epidemiologic data, clinical features and treatment data were extracted from medical records. […] No patient was admitted to the intensive care units or developed liver failure during hospitalization. | 2020-06-19 |
| 32559081 | All structures are available in CHARMM-GUI COVID-19 Archive (http://www.charmm-gui.org/docs/archive/covid19), so researchers can use these models to carry out innovative and novel modeling and simulation research for the prevention and treatment of COVID-19. | 2020-06-19 |
| 32559282 | SARS-CoV-2-targeted antiviral therapy was given to 9 patients, and immunomodulatory therapy to 18 patients. | 2020-06-19 |
| 32559308 | This led to the UK government advising patients with blood cancers to shield, massive re-organisation of NHS haematology and cancer services, and changes in treatment plans for thousands of patients. | 2020-06-19 |
| 32559354 | Her hepatitis and respiratory symptoms improved coincident with completing treatment with hydroxychloroquine, reduced immunosuppression, and intravenous gamma globulin (IVIG). | 2020-06-25 |
| 32559589 | The goal of this systematic review is to assess the published literature for seizure risk with chloroquine or hydroxychloroquine therapy in persons with and without epilepsy. […] With the COVID-19 pandemic, there is a desperate need for treatment against the SARS CoV-2 virus. […] Chloroquine or hydroxychloroquine is one proposed medication that has received substantial public attention. | 2020-06-23 |
| 32559771 | The world is faced with the dire challenge of finding an effective treatment against the rampaging COVID 19 pandemic. | 2020-06-19 |
| 32559820 | In the absence of a commonly agreed dosing protocol based on pharmacokinetic considerations, the dose and treatment duration for hydroxychloroquine (HCQ) COVID-19 disease currently vary across national guidelines and clinical study protocols. | 2020-06-19 |
| 32560203 | This review points to a growing interest in the development of compounds bearing a quinoxaline moiety for antiviral treatment. | 2020-06-22 |
| 32560322 | Numerous countries shut-down various activities that were considered “not essential.” Dental treatment was in this category and, at the time of writing, only non-deferrable emergencies are still allowed in many countries. […] Therefore, follow-up visits of ongoing active therapies (e.g., orthodontic treatment) must be handled taking special precautions. | 2020-06-22 |
| 32560646 | Herein, we reported a case receiving combination therapy with CP transfusion and hydroxychloroquine for the first time. […] These findings suggested that the effectiveness of combination therapy with CP and hydroxychloroquine may be non-optimal, and specific therapy needs to be explored. | 2020-06-23 |
| 32560658 | Four levels of thromboembolic risk were defined according to the severity of COVID-19 reflected by oxygen requirement and treatment, the body mass index, and other risk factors. […] In ICU patients, it is sometimes difficult to confirm a diagnosis of thrombosis, and curative anticoagulant treatment may also be discussed on a probabilistic basis. […] In all these situations, therapeutic doses of LMWH, or UFH in case of renal insufficiency with monitoring of anti-Xa activity, are proposed.In conclusion, intensification of heparin treatment should be considered in the context of COVID-19 on the basis of clinical and biological criteria of severity, especially in severely ill ventilated patients, for whom the diagnosis of pulmonary embolism cannot be easily confirmed. | 2020-06-23 |
| 32560665 | An integrated therapy including these drugs has the potential to improve outcomes in COVID-19. | 2020-06-23 |
| 32560694 | We aimed to analyze the demographics, clinical characteristics and treatment of 61 patients. […] Multi-site screening of SARS-CoV-2 including nasal and pharyngeal swabs, stool and sputum specimens could be considered to improve the diagnosis, treatment and infection control in patients with COVID-19. | 2020-06-23 |
| 32560744 | AGILE-ACCORD is a Bayesian multicentre, multi-arm, multi-dose, multi-stage open-label, adaptive, seamless phase I/II randomised platform trial to determine the optimal dose, activity and safety of multiple candidate agents for the treatment of COVID-19. […] Candidates that prevent uncontrolled cytokine release, prevention of viral replication, and other anti-viral treatment strategies are at various stages of development for inclusion into AGILE-ACCORD. […] However simulations have shown that around 16 participants are necessary to determine futility or promise of a candidate at a given dose (in efficacy evaluation alone) and between 32 and 40 participants are required across the dose-finding and efficacy evaluation when capping the maximum number of participants contributing to the evaluation of a treatment at 40. | 2020-06-22 |
| 32560745 | However, corticosteroids can have side effects, so simultaneous administration of immunoglobulin (IV-IG) and interferon-beta can help manage treatment using corticosteroids. […] The study subjects will be randomly allocated to three treatment arms: two experimental groups (two arms: Intervention 1 and Intervention 2) and one Control Group, which will be matched for age and sex using frequency matching method. […] Each eligible patient in the control arm will receive the standard treatment for COVID-19 based on WHO guidelines and the Ministry of the Health and Medical Education (MOHME) of Iran. […] Each patient in the Intervention Group 1 will receive the standard treatment for COVID-19 and dexamethasone, at the first 24 hours’ time of admission. | 2020-06-22 |
| 32560746 | Dornase alfa is a FDA-approved recombinant human DNAse 1 for the treatment of cystic fibrosis, which cleaves extracellular DNA and may break up cell-free DNA, loosening sticky mucus in the distal airways and reducing NETs-induced toxicity on alveolar pneumocytes. | 2020-06-22 |
| 32561113 | There is currently no specific treatment available for patients with COVID-19 infection. […] Numerous potential therapies, including supportive intervention, immunomodulatory agents, antiviral therapy, and convalescent plasma transfusion, have been used in clinical practice. […] Herein, we summarize the current potential therapeutic approaches for diseases related to COVID-19 infection and discusses the clinical value of blood transfusion-related technologies used in COVID-19 treatment. | 2020-06-20 |
| 32561148 | There is currently no drug that has been proven as an effective therapy for COVID-19. […] Several candidate drugs are being considered and evaluated for treatment. […] This includes clinically available drugs, such as chloroquine, hydroxychloroquine, and lopinavir/ritonavir, which are being repurposed for the treatment of COVID-19. […] This review article examines the evidence behind the potential use of these leading drug candidates for the treatment of COVID-19. […] Until the results of controlled trials are available, none of the suggested therapeutics is clinically proven as an effective therapy for COVID-19. | 2020-06-23 |
| 32561274 | Unfortunately no treatment therapy or vaccine is yet available to counter the SARS-CoV-2 infection, which substantiates the need to expand research efforts in this direction. | 2020-06-23 |
| 32561317 | This study aims to assess the prevalence of pulmonary adverse drug effects (ADEs) in patients with diabetes who were taking ACEI or ARBs to provide guidance as to how these medications could affect outcomes in acute respiratory illnesses such as SARS-CoV-2 infection. […] These analyses suggest that pharmacists and clinicians will need to consider the specific medication’s adverse event profile, particularly captopril, on how it may affect infections and other acute disease states that alter pulmonary function, such as COVID-19. | 2020-06-23 |
| 32561366 | The impact of COVID-19 on patients with Fabry disease receiving enzyme replacement therapy is still unknown. […] Many patients who receive treatment in the hospital experienced infusion disruptions due to fear of infection. […] Effects of temporary treatment interruption was described in more detail in other lysosomal storage diseases, but the recommencement of therapy does not fully reverse clinical decline due to the temporary discontinuation. […] When possible, home-therapy seems to be the most efficient way to maintain enzyme replacement therapy access during pandemic. […] Sentence take-home message: Home-therapy, when possible, seems to be the most efficient way to maintain enzyme replacement therapy access during pandemic in patients with Fabry disease. | 2020-06-23 |
| 32561438 | Multi-modality tobacco treatment increases rates of successful cessation by at least 20%. […] The COVID-19 pandemic has put a halt to many inpatient and outpatient medical visits deemed non-essential, including tobacco treatment. […] A military health facility on Fort Eustis in Virginia runs a successful tobacco treatment program and adapted it to pandemic times. | 2020-06-26 |
| 32561465 | We hypothesized that low molecular weight heparin (LMWH) may attenuate cytokine storm in COVID-19 patients therefore LMWH could be a valid adjunctive therapeutic drug for the treatment of COVID-19 pneumopathy. […] In this paper we review potential mechanisms involved in coagulation impairment following viral infection and the possible role of heparin in the treatment of COVID-19 patients. | 2020-06-23 |
| 32561660 | Humanitarian crises and emergencies, events often marked by high mortality, have until recently excluded palliative care-a specialty focusing on supporting people with serious or terminal illness or those nearing death. […] In the COVID-19 pandemic, palliative care has received unprecedented levels of societal attention. […] Unfortunately, this has not been enough to prevent patients dying alone, relatives not being able to say goodbye and palliative care being used instead of intensive care due to resource limitations. […] In 2018, the WHO released a guide on ‘Integrating palliative care and symptom relief into the response to humanitarian emergencies and crises’-the first guidance on the topic by an international body. […] Immediate steps to support better resolutions to ethical dilemmas of the provision of palliative care in humanitarian and emergency contexts will require honest debate; concerted research effort; and international, national and local ethical guidance. | 2020-06-20 |
| 32561681 | The requirement of patients on dialysis for regular treatment in settings typically not conducive to social distancing may increase their vulnerability to COVID-19. | 2020-06-20 |
| 32561873 | The pattern of pro-inflammatory cytokines induced in COVID-19 has similarities to those targeted in the treatment of rheumatoid arthritis. […] Several clinical studies are underway that test the effects of inhibiting IL-6, IL-1β or TNF or targeting cytokine signalling via Janus kinase inhibition in the treatment of COVID-19. | 2020-06-23 |
| 32561979 | Several new and repurposed drugs are being tested for their effectiveness in the treatment regime, and the development of vaccines is underway. | 2020-06-23 |
| 32561990 | Moving forward, further studies are needed to clarify the prevalence of the neurological complications of SARS-CoV-2 infection, investigate their biological backgrounds, and test treatment options. | 2020-06-23 |
| 32562070 | As an important cytokine in immune responses, IL-6 can be a double-edged sword: interference in the IL-6-IL-6 receptor signaling may save patients from cytokine release storm (CRS), but can also weaken the anti-infectious immunity, particularly in rheumatic patients, who may have received a long-term treatment with immunosuppressive/modulatory agents. […] Besides tocilizumab, several disease-modifying antirheumatic drugs (DMARDs) can also be applied in the treatment of COVID-19. | 2020-06-23 |
| 32562119 | This report provides an instruction manual to operationalize a same-day breast reconstruction protocol, to meet demands of providing appropriate cancer treatment during times of unprecedented resource limitations. | 2020-06-28 |
| 32562159 | There is no identified pharmacological therapy for COVID-19 patients, where potential therapeutic strategies are underway to determine effective therapy under such unprecedented pandemic. | 2020-06-23 |
| 32562325 | Potential drivers of disparate HNC survival resulting from the pandemic include (a) differential access to telemedicine, timely diagnosis, and treatment; (b) implicit bias in initiatives to triage, prioritize, and schedule HNC-directed therapy; and (c) the marked changes in employment, health insurance, and dependent care. | 2020-06-22 |
| 32562427 | Hypotension during treatment, severe myocardial injury and pericardial effusion were independent risk factors predicting the critical status of COVID-19 infection. […] Monitoring of vital signs and cardiac function of COVID-19 patients and applying potential interventions especially for those with hypotension during treatment, severe myocardial injury or pericardial effusion, is of vital importance. | 2020-06-20 |
| 32562480 | The search for a medication that could reduce risk of serious disease, and ideally of any manifestation of disease from SARS-CoV2, and of asymptomatic shedding of SARS-CoV2 is of urgent interest. | 2020-06-22 |
| 32562483 | In view of uncertainty associated with immunosuppressive treatments, such as corticosteroids and their possible secondary effects, including risks of secondary infections, we suggest immunotherapies as an adjunct therapy in severe COVID-19 cases. | 2020-06-22 |
| 32562547 | The spread of novel coronavirus disease (COVID-19) urged a never-seen coordinated global response to prepare the health system, including primary care, hospital facilities and intensive care units (ICUs). | 2020-06-20 |
| 32562561 | Immunomodulatory therapy with tocilizumab was used in 2 patients. | 2020-06-20 |
| 32562594 | The global pandemic calls for a revisiting of frameworks for the inclusion of pregnant women in research, as these women have an important stake in the prevention and treatment of Covid-19. | 2020-06-20 |
| 32562625 | We present a case of acute Stanford type A aortic dissection in a patient with covid-19 under treatment of ACE inhibitors. | 2020-06-22 |
| 32562701 | Apelin or its receptor agonists are of great potential treatment for COVID-19 through suppressing angiotensin-converting enzyme (ACE) and angiotensin II (Ang-II) production, as well as, down-regulating angiotensin receptor 1 (AT1R) and ACE2 up-regulation. | 2020-06-27 |
| 32562705 | Prodrugs of five of these nucleotide analogues (Cidofovir, Abacavir, Valganciclovir/Ganciclovir, Stavudine and Entecavir) are FDA-approved medications for treatment of other viral infections, and their safety profiles are well established. | 2020-06-28 |
| 32562911 | One of the therapeutic approaches for treatment of ARDS is a mesenchymal stem cell (MSC). […] COVID-19 treatment is currently focused on supportive therapies and no vaccine has been developed for it. | 2020-06-26 |
| 32562913 | Therefore, we suggest oral cancer patients require extra attention during COVID-19 pandemic and re-evaluation of current treatment paradigms in oral oncology is also needed. | 2020-06-26 |
| 32562915 | Critical patients have been shown to develop acute respiratory distress syndrome (ARDS) and hospitalization in intensive care units. […] In the absence of a therapy of proven efficacy, current management consists of off-label or compassionate use therapies based on antivirals, antiparasitic agents in both oral and parenteral formulation, anti-inflammatory drugs, oxygen therapy and heparin support and convalescent plasma. | 2020-06-26 |
| 32563134 | Main concern was to prevent overwhelming of the healthcare systems, mainly of the intensive care units (ICUs) by decreasing the spreading of the disease. | 2020-06-23 |
| 32563197 | In Italy the lack of preparation for supporting the patient load (shortage of personal protection devices, shortage of Intensive Care Unit (ICU) beds in comparison to other European Countries, and the poor early diagnostic and therapeutic activity) has led us to suggest a project that uses an online platform between General Practitioners and patients, in order to reduce moving infected individuals and to perform the diagnosis and treatment early on. | 2020-06-20 |
| 32563234 | We also discuss the possibility of using “smell and taste loss” as a screening tool for COVID-19 and treatment options in the post-SARS-CoV-2 infectious olfactory loss. | 2020-06-21 |
| 32563271 | When mild rhabdomyolysis lack of myoglobinuria and complications was diagnosed, treatment-related rhabdomyolysis was also avoided as no treatment related to COVID-19 was initiated yet. | 2020-06-21 |
| 32563494 | Presently, there is no antiviral medication or vaccination for the ECoVs, early induction of antiviral drugs remains the backbone of management. | 2020-06-24 |
| 32563519 | The data of patients’ demographics (age and gender), injury related data (fracture type, fractured site, osteoporosis fracture, concurrent fractures, injury mechanism, places where fracture occurred, ISS score, Gustilo-Anderson Classification for open fracture), mortality and treatment modality were compared between the two groups. | 2020-06-24 |
| 32563547 | These observations have crucial therapeutic implications since immunomodulatory drugs are at present the most likely best candidates for COVID-19 therapy. | 2020-06-24 |
| 32563584 | Various treatment strategies have been attempted. […] Although not yet FDA approved, it is being investigated for treatment of renal antibody-mediated rejection. […] Clinical trials of clazakizumab for treatment of COVID-19 are underway worldwide. | 2020-06-24 |
| 32563593 | To develop expert consensus recommendations regarding radiation therapy for gynecologic malignancies during the COVID-19 pandemic. […] An international committee of ten experts in gynecologic radiation oncology convened to provide consensus recommendations for patients with gynecologic malignancies referred for radiation therapy. […] Treatment priority groups were established. […] Hypofractionated radiation therapy should be used when feasible and recommendations regarding radiation dose, timing, and technique have been provided for external beam and brachytherapy treatments. […] The expert consensus recommendations provide guidance for delivering radiation therapy during the COVID-19 pandemic. | 2020-06-24 |
| 32563685 | The efficacy of renal denervation, and the use of sodium-glucose cotransporter 2 and aminopeptidase A inhibitors, have been studied for treatment of resistant hypertension. | 2020-06-24 |
| 32563697 | This biobank can provide applicants with biosamples, such as serum, DNA and RNA, and also the clinical and genomic data, so as to accelerate the COVID-19 treatment and prevention research in Taiwan. | 2020-06-24 |
| 32563787 | Povidone-iodine is an anti-bacterial and anti-viral that is affordable and available over-the-counter and may demonstrate advantages over mupirocin as a sinus irrigation therapy. […] Outcomes were post-treatment culture negativity (primary) and Sinonasal Outcome Test-20 and Lund-Kennedy endoscopic score change (secondary). […] Of the 62 subjects analyzed, post-treatment culture negativity rate was higher in the MUP (14/20, 70%) group compared to the PI (9/21, 43%) and SAL (9/19, 47%) groups, although this was not significant (p = 0.29). […] In patients who have had prior sinus surgery with acute exacerbations of CRS and gram-positive bacteria on culture, mupirocin sinus irrigations achieved a better post-treatment culture “control” rate compared to saline and povidone-iodine. | 2020-06-25 |
| 32563812 | Remdesivir (GS-5734), a viral RNA-dependent RNA polymerase (RdRP) inhibitor that can be used to treat a variety of RNA virus infections, is expected to be an effective treatment for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. […] Furthermore, perspectives regarding the use of remdesivir for the treatment of COVID-19 are also discussed. | 2020-06-23 |
| 32563813 | The current COVID-19 pandemic caused by the recently emerged coronavirus SARS-CoV-2 is one significant and unfortunate example of what the world will have to face in the future with emerging viruses in absence of appropriate treatment. | 2020-06-24 |
| 32563940 | Till now there are no vaccines and explicit medicines available for the treatment of COVID-19 disease, therefore the initiatives like public health and social measures are helpful in limiting the quantity of contaminations and saving lives. | 2020-06-26 |
| 32563969 | Information on treatment of COVID-19 infection in renal transplant recipients is scarce, especially in symptomatic patients and patients with recent major clinical events. […] Currently available expert opinions suggest reduction of immunosuppression therapy for renal transplant recipients with symptomatic COVID-19 infection with either antiviral drugs, hydroxychloroquine and/or azithromycin. […] Inspired by our experience in treatment of CMV pneumonia and literature data on the potential benefit of convalescent plasma for treatment of different viral diseases we suggest use of the hyperimmune anti-CMV gamma globulins in addition to other available therapies. | 2020-06-26 |
| 32563999 | Management of COVID-19 is mainly by supportive therapy along with mechanical ventilation in severe cases. | 2020-06-21 |
| 32564002 | At present, neither specific curative treatment nor vaccines for novel coronavirus 2019 (COVID-19) are available. […] There is an urgent need to look for alternative strategies for COVID-19 treatment especially in the case of severe and/or critically ill patients with cytokine release syndrome (CRS). […] Therefore, convalescent plasma could be a promising treatment option for severe COVID-19 patients. […] At the time of plasma therapy both patients were on mechanical ventilation and received antiviral agents and a full scale of supportive care. […] Both patients were weaned from mechanical ventilation within 2 weeks of treatment. […] Our experience indicates that convalescent plasma therapy is well tolerated and could potentially improve clinical outcomes. […] Optimal dose and timing as well as precise assessment of clinical benefit of convalescent plasma therapy will need further investigation in larger, well-controlled trials. […] This is the first report of the successful use of convalescent plasma in the treatment of critically ill patients with COVID-19 infection in Hungary. | 2020-06-23 |
| 32564028 | Against the background of the pandemic caused by infection with the SARS-CoV-2 virus, the German Respiratory Society has appointed experts to develop therapy strategies for COVID-19 patients with acute respiratory failure (ARF). […] Based on the current knowledge, inhalation therapy, nasal high-flow therapy (NHF), continuous positive airway pressure (CPAP), or noninvasive ventilation (NIV) can be performed without an increased risk of infection to staff if PPE is provided. […] In this situation, the oxygen therapy can be escalated to CPAP or NIV when the criteria for endotracheal intubation are not met. | 2020-06-21 |
| 32564046 | Numerous observational studies indicate a relationship between arterial hypertension and its treatment and SARS-Cov-2 coronavirus infection. […] It has been shown that the use of recombinant ACE2 can be potentially beneficial in COVID-19 therapy by limiting the entry of the virus into the cell. | 2020-06-25 |
| 32564068 | The influence of inflammatory bowel disease (IBD) medication and IBD itself on COVID-19 is controversial. […] To determine COVID-19 prevalence/exposure, perception and information sources, medication compliance, patient behaviour and physician contact among patients with IBD compared with non-IBD controls. […] Patients taking immunosuppressants were concerned about interactions between medication and COVID-19, whereas patients taking 5-aminosalicylates were not. […] Nonetheless, 96.4% of patients adhered to continuing their medication. […] Patients with IBD are significantly more affected by the COVID-19 pandemic than their non-IBD peers, but they continue to adhere to their medication regimens. | 2020-06-21 |
| 32564256 | Regenerative medicine offers various cell-tissue therapeutics and related products, such as stem cell therapy, natural killer (NK) cell therapy, Chimeric antigen receptor (CAR) T cell therapy, exosomes, and tissue products. […] Notably, having the potentials to exert cytotoxic effects on infected cells and induce interferon production probably make NK cells a candidate for COVID-19 cell therapy. […] The paper aims to briefly consider current options for COVID-19 therapy to show that there is no specific cure for COVID-19, and then assess the real opportunities and range of promises regenerative medicine can provide for specific treatment of COVID-19. | 2020-06-24 |
| 32564270 | In contrast, it has also been hypothesized that overactive immune responses may trigger a cytokine storm associated with clinical deterioration, which has generated an interest in certain immunosuppressant drugs as potential treatment for COVID-19. […] We would like to present the first case report of a patient who was formally diagnosed with COVID-19 while being under disease-modifying treatment with rituximab, an anti-CD20 B cell depleting agent, for multiple sclerosis. | 2020-06-24 |
| 32564306 | Prognosis or optimal treatment strategy for renal transplant recipients in SARS-CoV-2 infection is still unknown. […] In addition, COVID-19 treatment and the maintenance immunosuppression strategy is still under debate. | 2020-06-24 |
| 32564623 | In this review, we focus on potential druggable targets and suitable therapeutics, currently being explored in clinical trials, to treat SARS-CoV-2 infection. | 2020-06-25 |
| 32564693 | Several factors have been proposed to explain the high death rate of the coronavirus disease 2019 (COVID-19) outbreak, including hypertension and hypertension-related treatment with Renin Angiotensin System inhibitors. […] Our data do not support a significant interference of hypertension and antihypertensive therapy on COVID-19 lethality. | 2020-06-22 |
| 32564983 | The aim of the study was to describe the population and diagnoses and evaluate the main judgment criteria, defined as the ‘ability of teleconsultation to properly indicate a physical consultation for fair diagnosis and treatment in eye emergencies’. | 2020-06-25 |
| 32564984 | Treatment and evolution in octogenarians are not well defined. […] Retrospective observational study of consecutive patients admitted in the period between March 23 and April 12, 2020 with confirmed SARS-CoV-2 infection, with pneumonia by radiological study or chest tomography, whith STC criteria and who received treatment. […] STC mortality from SARS-CoV-2 is high despite treatment. | 2020-06-25 |
| 32565030 | There is no single therapeutic approach to the treatment of COVID-19 and the associated immune disorder. | 2020-06-25 |
| 32565132 | At least three inflammatory disorders or syndromes associated with immune dysfunction have been described in the context of cellular therapy. […] Here we discuss these diseases, their management, and potential applications of these treatment in the context of COVID-19. […] We also discuss current cellular therapies that are being evaluated for the treatment of COVID-19 and/or its associated symptoms. | 2020-06-25 |
| 32565134 | Middle East Respiratory Syndrome Coronavirus (MERS-CoV) causes severe respiratory in human with high mortality and it has been a challenge to determine optimum treatment for MERS-CoV-induced respiratory infection. | 2020-06-28 |
| 32565195 | There is currently an increased interest in using the antimalarials chloroquine and hydroxychloroquine for the treatment of other diseases, including cancer and viral infections such as COVID-19. | 2020-06-28 |
| 32565199 | A treatment with lopinavir/ritonavir and hydroxychloroquine twice daily was started. […] Consequently, treatment with lopinavir/ritonavir and hydroxychloroquine was stopped. | 2020-06-25 |
| 32565232 | To do so, the Brazilian Society of Thrombosis and Hemostasis (BSTH) and the Thrombosis and Hemostasis Committee of the Brazilian Association of Hematology, Hemotherapy and Cellular Therapy (ABHH) have constituted a panel of experts to carefully review and discuss the available evidence about this topic. | 2020-06-25 |
| 32565264 | Prone positioning is an adjuvant therapy used to treat COVID-19 pneumonia complicated by acute respiratory distress syndrome. | 2020-06-24 |
| 32565306 | Clinical molecular laboratory professionals are at the frontline of the response to the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic, providing accurate, high-quality laboratory results to aid in diagnosis, treatment, and epidemiology. | 2020-06-28 |
| 32565309 | This study aims to find a new antiviral combination regimen by investigating the frequency of clinically relevant and objectively identified comorbidities, and the clustering of these clinical syndromes and varying results of treatment with antiviral drugs in patients hospitalized with severe COVID-19. […] This study recruited 151 severe COVID-19 infection cases diagnosed in our hospital examination and illustrated the clinical potential during a consecutive 25-day medication period. […] Our results for the first time suggest that a quadruple combination therapy (Ribavirin, Lopinavir/ritonavir, Umifenovir, and Lianhua Qingwen) can be considered as a preferred treatment approach to severe COVID-19 patients. […] After treatment, abnormal coagulation and leukocyte had markedly improved with a better prognosis. […] This study expands the understanding of the co-occurrence of combination therapy in patients with COVID-19, which provides the probability of developing novel combined therapy. | 2020-06-25 |
| 32565362 | These findings may provide additional insight into the prevention and treatment of SARS-CoV-2 infection, in particular for patients with these 10 vulnerable cancer types. | 2020-06-25 |
| 32565364 | Similarly, the role of oxygen therapy as an anti-inflammatory strategy is evident and access to oxygen therapy should be prioritized to avoid the aggravation of COVID-19 infection. | 2020-06-24 |
| 32565398 | In the absence of direct evidence examining efficacy of providing additional micronutrients or conditional amino acids to standard care, registered dietitian nutritionists must rely on clinical expertise and indirect evidence to guide medical nutrition therapy for patients infected with COVID-19. | 2020-06-25 |
| 32565599 | The review focuses on the various approaches adopted till date for developing effective therapeutic strategies including combination of drugs, vaccine therapy, and convalescent plasma therapy to combat this viral outbreak. | 2020-06-23 |
| 32565620 | Asymptotic individuals either recovered without undergo treatment or moved to infected class after some duration. | 2020-06-23 |
| 32565894 | The onset of the COVID-19 pandemic has changed the face of the treatment of breast cancer and breast reconstruction globally. […] However, due to the prioritisation of the critically ill and diversion of the work force, breast cancer treatment has drastically changed. | 2020-06-23 |
| 32565897 | International guidelines (CDC; ASCO, NCCN and ESMO) were considered as a background for analysis, as well as institutional guidelines and an open ad hoc survey administered to 114 healthcare professionals from the scientific societies involved in this study.The recommendations are grouped as follows: 1) general care interventions-training of the personnel, cleaning and disinfection of the hospital premises and patient scheduling; 2) treatment decisions-patient care, surgeries, immunosuppressive therapy, radiotherapy and screening; 3) ethical considerations-optimisation of resources, end-of-life care for critically-ill patients; 4) management of hospitalised patients; and 5) wellbeing of the healthcare team.The general recommendation arising from the study is that the management of cancer patients must adapt to the exceptional pandemic status quo without disregarding treatment or cure options. | 2020-06-23 |
| 32565905 | In our Radiation Oncology Department, experienced in administering hypofractionated treatments (partial irradiation in breast cancer, moderate hypofractionation in localized prostate cancer, etc), we have increased the hypofractionated treatment indications. […] We report the results of the first 100 patients who have experienced radiotherapy treatment since the state of alarm (66 women and 34 men). | 2020-06-23 |
| 32565968 | Moreover, evolving treatment strategies and novel ways of addressing the needs of oncology patients in the new context of the pandemic are discussed. | 2020-06-23 |
| 32566237 | However, the optimal treatment for respiratory failure in COVID-19 patients is yet to be determined. | 2020-06-22 |
| 32566261 | Development of new vaccines and therapeutics are important to achieve long-term prevention and control of the virus. | 2020-06-23 |
| 32566414 | The direct inhibition of the PTGS2 gene product can be considered as another therapeutic strategy for SARS-CoV-2 infection and could suggest six approved PTGS2 inhibitor drugs for the treatment of COVID-19. | 2020-06-23 |
| 32566429 | The widely used management for ARDS in COVID-19 has been in line with the standard approach, but the need to adjust the treatment protocols has been questioned based on the reports of higher mortality risk among those requiring mechanical ventilation. […] Treatment options for this widespread disease are limited and there are no definitive therapies or vaccines until now. | 2020-06-23 |
| 32566483 | Coronavirus disease 2019 (COVID-19) is a major public health challenge, and the current antiviral arsenal for treatment is limited, with questionable efficacy. […] In this article, we argue for the potential benefits of using doxycycline with either hydroxycholoroquine or other putative agents for COVID-19 treatment, as doxycycline has antiviral and anti-inflammatory activities by dampening the cytokine storm and to prevent lung damage. | 2020-06-23 |
| 32566556 | One cohort study on MERS indicated that macrolide therapy was not associated with a significant reduction in 90-day mortality (adjusted OR 0.84, 95% CI: 0.47-1.51, P=0.56) and improvement in MERS-CoV RNA clearance (adjusted HR 0.88, 95% CI: 0.47-1.64, P=0.68). | 2020-06-23 |
| 32566558 | Supportive treatment is an important and effective part of the management for patients with life-threatening diseases. | 2020-06-23 |
| 32566562 | Intravenous immunoglobulin (IVIG) is usually used as supportive therapy, but the treatment of COVID-19 by IVIG is controversial. […] This rapid review aims to explore the clinical effectiveness and safety of IVIG in the treatment of children with severe COVID-19. […] The existing evidence is insufficient to support the efficacy or safety of IVIG in the treatment of COVID-19. | 2020-06-23 |
| 32566563 | We included studies about the content of the consultation (such as symptoms, therapy and prevention, policy, public service), screening of suspected cases, the provision of advice given to those people who may have symptoms or contact history. […] During the SARS epidemic, the proportions of people asking for consultation for symptoms, prevention and therapy, and psychological problems were 35.0%, 22.0%, and 23.0%, respectively. […] Telemedicine services should focus on the issues that the public is most concerned about, such as the symptoms, prevention and treatment of the disease, and provide reasonable advice to patients with symptoms or people with epidemic history. | 2020-06-23 |
| 32566564 | Glucocorticoids are widely used in the treatment of various pulmonary inflammatory diseases, but they are also often accompanied by significant adverse reactions. […] Published guidelines point out that low dose and short duration systemic glucocorticoid therapy may be considered for patients with rapidly progressing coronavirus disease 2019 (COVID-19) while the evidence is still limited. […] The use of systemic glucocorticoid therapy prolonged the duration of hospital stay in all patients (COVID-19, SARS and MERS). […] Glucocorticoid therapy was found to reduce the duration of fever, but not mortality, duration of hospitalization or lung inflammation absorption. | 2020-06-23 |
| 32566569 | These trials are classified into 4 categories based on treatment modalities, including chemical drugs (CDs), biological therapies (BTs), traditional Chinese medicine (TCM) treatments and other therapies. […] More trials on traditional Chinese medical treatment use 2 or more PEs than those on CDs or biological treatments (57.6%, 39.4% and 40.5%, respectively). | 2020-06-23 |
| 32566579 | We aimed to describe the clinical characteristics of hospitalized patients with confirmed COVID-19 infection in Shaoxing, and provide an insight into the treatment of COVID-19 across China and elsewhere. […] Epidemiological, demographic, clinical, laboratory, radiological feature, and treatment data were all collected. […] All patients were given psychological counseling, 15 (93.8%) patients were administered with antiviral therapy, 8 (50%) received empirical antibiotic treatment, and 5 (31.3%) patients were given systematic corticosteroids. […] Currently, there is no effective drug treatment or vaccine for COVID-19, and psychological counseling cannot be ignored. | 2020-06-23 |
| 32566603 | Severe group required more main interventions such as received antiviral therapy (OR 1.69; 95% CI, 1.23 to 2.32, P=0.001), corticosteroids (OR 5.07; 95% CI, 3.69 to 6.98, P<0.001), CRRT (OR 37.95; 95% CI, 7.26 to 198.41, P<0.001) and invasive mechanical ventilation (OR 129.35; 95% CI, 25.83 to 647.68, P<0.001). | 2020-06-23 |
| 32566621 | The value of chest computed tomography (CT) is debatable during the treatment of COVID-19 patients. […] The automatic quantitative model based on VB-Ne can supply useful information for ARDS risk stratification in COVID-19 patients during treatment. | 2020-06-23 |
| 32566896 | Due to their small size and high stability, single-domain antibodies might have the ability to be administered by an inhaler making them potentially attractive therapeutics for respiratory infections. | 2020-06-26 |
| 32566934 | Additionally, this might augment and refine diagnosis and prognostic management as well as treatment. | 2020-06-23 |
| 32567239 | As hospitals have experienced a surge of Covid-19 patients, investigators of Covid-19 treatment trials face a difficult problem: when an institution has more eligible and interested patients than trial slots, who should be enrolled? […] Defining a clear strategy for selecting participants for “high-demand” Covid-19 treatment trials is important to avoid ad hoc and potentially biased decision-making by local investigators, which could inadvertently compromise a trial’s social value, participants’ interests, or fairness. | 2020-06-22 |
| 32567260 | Coronavirus disease 2019 (COVID-19) has resulted in an ongoing pandemic; however, the socioeconomic burden of COVID-19 treatment in the pediatric population remains unclear. […] The study showed that individual treatment costs for children with COVID-19 are approximately USD 2,192 under the Korean National Health Insurance Service System. […] Tailored COVID-19 treatment strategies by age group may lower costs and increase the effectiveness of resource allocation. | 2020-06-25 |
| 32567487 | Molecular peptide docking with Moringa oleifera, phytochemicals (aqueous and ethanolic) leaf extracts of flavonoids (3.56 ± 0.03), (3.83 ± 0.02), anthraquinone (11.68 ± 0.04), (10.86 ± 0.06) and hydroxychloroquine present therapy of COVID-19 in Pakistan for comparative study. | 2020-06-22 |
| 32567501 | Statistics show alarming numbers of infected and killed in the world, caused by the Covid-19 pandemic, which still doesn’t have a specific treatment and effective in combating all efforts to seek treatments and medications against this disease. | 2020-06-22 |
| 32567505 | In January 2020, the coronavirus disease 2019 (COVID-19) outbreak in Italy necessitated rigorous application of more restrictive safety procedures in the management and treatment of patients with cancer to ensure patient and staff protection. | 2020-06-25 |
| 32567656 | For healthcare providers, specifically military and federal public health personnel, prompt and accurate diagnosis and isolation of SARS-CoV-2 novel coronavirus patients provide a two-fold benefit: (1) directing appropriate treatment to the infected patient as early as possible in the progression of the disease to increase survival rates and minimize the devastating sequelae following recovery and remission of symptoms; (2) provide critical information requirements that enable commanders and public health officials to best synchronize policy, regulations, and troop movement restrictions while best allocating scarce resources in the delicate balance of risk mitigation versus mission readiness. | 2020-06-22 |
| 32567800 | Government guidelines and restrictions implemented to mitigate the risk of COVID-19 community transmission have forced radiation therapy departments to promptly adjust to the significant impact on our ability to deliver best clinical care. […] The aim of this paper is to describe the experience of the Peter MacCallum Cancer Centre’s (Peter Mac) radiation therapy services during the preliminary stages of the COVID-19 pandemic in minimising risk to patients, staff and our clinical service. […] Each of these initiatives had a focus on continuum of clinical care, whilst minimising risk of cross infection for our radiation therapy workforce and patients alike. […] Initiatives included, but were not limited to, establishing COVID-Eclipse clinical protocols, remote access to local applications, implementation of Microsoft Teams, personal protective equipment (PPE) guidelines and virtual ‘Division of Radiation Oncology’ briefing/updates. […] The COVID-19 pandemic has dictated change in conventional radiation therapy practice. […] It is hoped that by sharing our experiences, the radiation therapy profession will continue to learn, adapt and navigate this period together, to ensure optimal outcomes for ourselves and our patients. | 2020-06-22 |
| 32567872 | Due to stringent but necessary infection control mandates, the COVID-19 pandemic is increasingly resulting in family separation from loved ones admitted to intensive care units (ICUs). […] Consequently, ICU families are facing additional barriers in fully understanding the complex medical needs of their loved ones (and hence being able to make informed care decisions on their behalf); establishing rapport and bonding with nurses and other members of the ICU treatment team; and, in the event that a loved one passes, achieving closure. | 2020-06-22 |
| 32567938 | Pending further clinical studies able to clarify the infection and transmission dynamics, it is therefore important to apply also in children all preventive and hygiene measures recommended by the health authorities during dental treatment. […] When possible, it is recommended to employ minimally invasive procedures and ART (Atraumatic Restorative Treatment). […] Ozone therapy could be of great help in the control of the progression of the asymptomatic carious lesions, especially during the Phase 2 of reopening, when we should to minimise the use of rotating instruments producing aerosols. | 2020-06-24 |
| 32567949 | Tele-orthodontics demonstrated to be a viable tool to continue at least some orthodontic care in times of emergency, but it may be considered an appropriate solution and addition even in normal times to ease therapy demands for both the orthodontist and the patient, while reducing time and money spent, without an excessive decrease in orthodontic quality. | 2020-06-24 |
| 32567972 | No drug has yet been approved for the treatment of SARS-CoV-2 infection; however, preclinical investigations suggested repurposing of several FDA-approved drugs for clinical trials. | 2020-06-25 |
| 32567979 | We strongly believe the final compounds can become COVID-19 therapeutics, with huge international support.Communicated by Ramaswamy H. | 2020-06-22 |
| 32567989 | Utilizing contemporary strategies, these phyto-compounds from a natural origin might establish a reliable medication or support lead identification. | 2020-06-22 |
| 32568009 | Psoriasis is a systemic immune-mediated inflammatory disease that requires consistent treatment and follow-up. […] We provide guidelines for optimizing care for psoriasis patients, including considerations for medication management, lifestyle adjustments, and utilization of telemedicine. | 2020-06-22 |
| 32568012 | COVID-19 has ravaged the world and is the greatest of pandemics in modern human history, in the absence of treatment or vaccine, the mortality and morbidity rates are very high. […] Based on proven therapeutic, that is, immunomodulatory, antioxidant and anti-inflammatory roles and plausible potential against n-CoV-2 proteins, Indian ginseng could be one of the alternatives as an antiviral agent in the treatment of COVID 19. | 2020-06-22 |
| 32568013 | Thus, paving the way for further biological validation as a potential treatment.Communicated by Ramaswamy H. | 2020-06-22 |
| 32568027 | Furthermore, we determined that the sensitivity of the two viruses to three established inhibitors of coronavirus replication (remdesivir, alisporivir and chloroquine) is very similar, but that SARS-CoV-2 infection was substantially more sensitive to pre-treatment of cells with pegylated interferon alpha. | 2020-06-22 |
| 32568102 | A nucleic acid test for SARS-CoV-2 was positive, and the patient was then transferred to the Department of Infectious Disease for further special treatment. | 2020-06-25 |
| 32568282 | The likelihood is that combination therapy addressing both upstream and downstream pathways may be required to prevent progression of severe COVID-19 infection in susceptible older patients with comorbidities and we believe further studies are now warranted to specifically target such at-risk groups who are more prone to worse outcomes. | 2020-06-25 |
| 32568401 | Seven individuals with COVID-19 acquired outside the community (age, 20-70 years; 3 [42%] women) were moved from quarantine to a hospital for standard isolation treatment. | 2020-06-25 |
| 32568411 | We read with great interest the research article written by Borku Uysal B et al which is in accordance with the so far accumulating knowledge that tocilizumab is an effective treatment for COVID-19 cytokine storm syndrome (CSS). | 2020-06-22 |
| 32568444 | These factors may have affected the principles of evidence-based medicine and encouraged the widespread use of non-tested pharmacological and aggressive respiratory support therapies, even in intensive care units (ICUs). | 2020-06-22 |
| 32568496 | To describe the recommendations for diagnosis, treatment and follow-up of patients with TC amidst COVID- 19 pandemic. […] The biology of TC requires immediate care of patients during diagnosis, initial surgical therapy and management of recurrent disease. […] Complications of therapy and symptomatic patients represent medical emergencies and should be treated immediately. | 2020-06-22 |
| 32568497 | Prognosis is determined by several characteristics, being the most important the presence of lymph nodes, in which case, treatment should not be delayed. […] Priority classifications, based on the oncological outcomes when treatment is delayed, have been made in order to separate deferrable disease from the one that needs high priority treatment. […] In penile cancer with low risk of progression, surgical treatment can be delayed, but other options must be considered, like topical treatment or laser therapy. […] In cases with intermediate risk of progression, surgical treatment may be delayed up to three months, but we must consider radiation therapy and brachytherapy as effective options. […] In case of superficial non-invasive disease, topical treatment is effective in absence of lymph node involvement. […] Non-deferrable surgical treatment must be performed by an experienced surgeon and as an outpatient procedure when possible. | 2020-06-22 |
| 32568498 | This review discusses the impact of COVID-19 in Female Urology, revises the most important disorders in this field and how their diagnosis and treatment may be modified due to the current pandemic. | 2020-06-22 |
| 32568613 | Lack of specific drug molecules or treatment strategy against this disease makes it more devastating. […] Altogether, our study shows that these three polyphenols can be used as potential inhibitors against SARS CoV-2 Mpro and are promising drug candidates for COVID-19 treatment.Communicated by Ramaswamy H. | 2020-06-22 |
| 32568662 | We evaluated the clinical course of asymptomatic and mildly symptomatic patients with laboratory-confirmed coronavirus disease (COVID-19) admitted to community treatment centers (CTCs) for isolation in South Korea. | 2020-06-22 |
| 32568663 | As a part of measures to decrease spikes in coronavirus disease (COVID-19) cases and deaths outside of hospitals, the government of South Korea introduced a plan for community treatment centers (CTCs) to isolate and monitor patients with mild COVID-19 symptoms. | 2020-06-22 |
| 32568665 | We describe the structure and operating protocols of a community treatment center (CTC) run by Seoul National University Hospital (SNUH) in South Korea. | 2020-06-22 |
| 32568722 | To describe the epidemiological features and clinical symptoms of patients receiving remote diagnosis and treatment at the online outpatient clinic of our hospital during the coronavirus disease 2019 (COVID-19) outbreak, and to analyze the outcomes and advantages of telemedicine during the COVID-19 pandemic. […] All patients receiving remote diagnosis and treatment and consultation services over COVID-19 concerns at the online outpatient clinic of Henan Provincial People’s Hospital from January 24 to February 17, 2020, were collected. […] A total of 4,589 patients receiving remote diagnosis and treatment were recruited. […] Remote diagnosis and treatment offered via the online outpatient consultation effectively reduce the burden on hospitals, prevent overcrowding, reduce the risk of cross-infection and relieve patients’ anxiety during the COVID-19 outbreak, which play an essential role in the pandemic management. | 2020-06-22 |
| 32568727 | The system helped patients self-assess their conditions and update the multi-disciplinary team through a telemedicine form stored on a cloud service, based on which the team made treatment decisions accordingly. […] The results are useful for medical staff to identify disease progression, and hence, make appropriate and timely treatment decisions. | 2020-06-24 |
| 32568771 | Nine of 10 persons on antiretroviral therapy (ART) presented with only mild COVID-19 symptoms. | 2020-06-22 |
| 32568969 | As the coronavirus disease 2019 (COVID-19, also called severe acute respiratory syndrome coronavirus-2, SARSCoV-2) outbreak accelerates, vigorous and diverse efforts were made in developing treatment strategies. […] This article reviewed the pharmacological development of potential adjuvants for COVID-19 treatment. | 2020-06-22 |
| 32569196 | As an important means of treatment now, Chinese medicine plays a significant role in the treatment of respiratory diseases in China. […] Randomized controlled trials will be included if they recruited participants with COVID-19 for assessing the effect of Chinese medicine vs control (placebo, no treatment, and other therapeutic agents). […] The available evidence of the treatment of COVID-19 with traditional Chinese medicine will be summarized, and evaluation of the efficacy and the adverse effects of these treatments will be made. | 2020-06-22 |
| 32569204 | The purpose of this study is to evaluate the efficacy and safety of Chinese patent medicine injection in the treatment of COVID-19. […] Evidence regarding the efficacy and safety of Chinese patent medicine injection in the treatment of COVID-19 will be provided to clinicians.PROSPERO registration number: CRD42020182725. | 2020-06-22 |
| 32569363 | There was a non-statistically significant lower mortality in the treatment group (52% versus 62.1% P = 0.09). | 2020-06-22 |
| 32569491 | All patients were on ACE inh/ARBs or other antihypertensive therapy unless no contraindication was present. […] Kaplan-Meir curve analysis displayed that patients on ACE inh/ARBs therapy had higher incidence of in-hospital death than those who were not. […] The present study has found that the use of ACE inh/ARBs therapy might be associated with an increased in-hospital mortality in patients who were diagnosed with Covid-19 pneumonia. […] It is likely that ACE inh/ARBs therapy might not be beneficial in the subgroup of hypertensive Covid-19 patients despite the fact that there might be the possibility of some unmeasured residual confounders to affect the results of the study. | 2020-06-22 |
| 32569493 | Psoriasis patients treated with immunosuppressive medications, including those under biologic therapy, are a special group. […] Many scientific societies do not recommend discontinuing therapy in patients without symptoms or confirmation of SARS-CoV-2 infection despite the potentially higher risk of respiratory tract infections in this patient population. […] Based on our own experience, we present the organization of the biologic therapy within the unit of a Single Specialty Infectious Hospital. | 2020-06-26 |
| 32569708 | Treatment options for the pulmonary phase include: Hydroxychloroquine, Remdesivir, Lopinavir/Ritonavir. | 2020-06-28 |
| 32569797 | The interdisciplinary panel of experts emphasize a stepwise, shared decision-making approach in the management of immunosuppressive therapy. | 2020-06-24 |
| 32569833 | Clinical studies using the XPO1 inhibitor selinexor as a therapy for COVID-19 infection are in progress. | 2020-06-27 |
| 32570016 | CIoMT is a promising technology for rapid diagnosis, dynamic monitoring and tracking, better treatment and control without spreading the virus to others. | 2020-06-26 |
| 32570043 | In the TOCI group, all received anti-viral therapy and 40% also received glucocorticoids. […] Despite the confounding factors, this suggests that therapy time in anti-cytokine randomized trials will be key. | 2020-06-28 |
| 32570174 | Mesenchymal stem cells appear to be a promising cell therapy given that they favorably modulate the immune response to reduce lung injury. […] Ultimately, vaccines, natural killer cells and induced-pluripotent stem cell-derived virus-specific cytotoxic T lymphocytes may offer off-the-shelf therapeutics for preventing coronavirus reemergence. | 2020-06-26 |
| 32570196 | The therapy of chronic patients has been prolonged for 6 months via an electronic prescription. | 2020-06-25 |
| 32570240 | We have analyzed all patients with prostate cancer undergoing hormonal or chemotherapy treatment and receiving telephone and in person pre-triage between March 1 and 27, 2020, at the Tortora Hospital, Pagani, Italy. […] Both patients were receiving LHRH agonist therapy, and 1 patient was receiving enzalutamide. […] Retroviral therapy, antibiotics, heparin, and chloroquine were prescribed at the beginning. […] One patient also received tocilizumab as a salvage treatment. […] Investigating whether hormonal therapy, especially in advanced disease, acts as a protective factor or a risk factor during COVID-19 could be useful. | 2020-06-22 |
| 32570882 | Lower rates of mortality and intubation have been reported in studies investigating statin therapy in influenza infection, and statin therapy was shown to increase viral clearance from the blood during chronic hepatitis C infection. | 2020-06-23 |
| 32570995 | To date, there has been no definite therapy for COVID-19. | 2020-06-23 |
| 32571007 | Nano intervention is discussed in terms of designing effective nanocarriers to counter the conventional limitations of antiviral and biological therapeutics. | 2020-06-23 |
| 32571115 | The utility of hydroxychloroquine for the prophylaxis and treatment of alarmingly rising COVID-19 infection has been widely explored in several studies. | 2020-06-23 |
| 32571182 | In the second stage, when the multiplication of the virus decreases and threatening pathological processes of excessive inflammation, acute respiratory distress syndrome, pulmonary edema, hypoxia, and secondary bacterial pneumonia and sepsis events develop, a pathogenetic therapeutic approach including extracorporeal blood oxygenation, detoxification, and anti-inflammatory and anti-bacterial therapy seems to be the most effective way for the patient’s recovery. | 2020-06-25 |
| 32571224 | PTGD, antibacterial and anti-virus combined with interferon inhalation treatment were successful. | 2020-06-25 |
| 32571455 | A retrospective analysis was performed for the clinical data of 53 children who were confirmed with asymptomatic or subclinical COVID-19, including epidemiological history, clinical typing, co-infection, time to clearance of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) nucleic acid in nasopharyngeal swabs, laboratory examination results, length of hospital stay, and treatment outcome. | 2020-06-25 |
| 32571532 | After a series of conservative treatment which did not work at all, posterior open reduction and pedicle screw internal fixation of the thoracolumbar fracture were performed in Wuhan Union Hospital. | 2020-06-25 |
| 32571605 | Para-clinical investigations including laboratory tests and radiologic findings play an important role in early diagnosis and treatment monitoring of COVID-19. | 2020-06-25 |
| 32571606 | In the absence of a vaccine or medication to help prevent or decrease the effects of the disease, we suggest that amantadine may reduce the effects of COVID-19. | 2020-06-25 |
| 32571730 | Several studies have proposed that anti-IL-6 receptor antibodies, such as tocilizumab, play an important role in the treatment of severe acute respiratory infection associated with SARS-CoV-2. […] However, the role of anti-IL-1 receptor antibodies, such as anakinra, in the treatment of COVID-19 has not been established. […] We present a case report of a 51-year-old man diagnosed with severe respiratory infection associated with SARS-CoV-2 that was refractory to antiviral and anti-IL-6 treatment, with a favourable clinical outcome and analytical improvement after treatment with anti-IL-1 (anakinra). | 2020-06-25 |
| 32571773 | Patients infected with the novel coronavirus (SARS-CoV-2) are being treated empirically with oseltamivir, but there is little evidence from randomised controlled trials to support the treatment of coronavirus infections with oseltamivir. | 2020-06-26 |
| 32571831 | To determine the role of steroids in in-hospital mortality, patients admitted with SARS-CoV-2 pneumonia and treated with steroids were compared to patients not treated with steroids, adjusting by a propensity-score for steroid treatment. […] Median time to steroid treatment from symptom onset was 10 days (IQR 8-13). […] Steroid treatment reduced mortality by 41.8% relative to no steroid treatment (RRR 0,42 [0.048- 0.65). […] Initial treatment with 1 mg/kg/day of methylprednisolone versus steroid pulses was not associated with in-hospital mortality (13.5% [42/310] versus 15.1% [13/86], OR 0.880 [0.449-1.726], p=0.710).Conclusions: Our results show that survival of patients with SARS-CoV2 pneumonia is higher in patients treated with glucocorticoids than in those not treated. | 2020-06-23 |
| 32571838 | Developing therapeutics against SARS-CoV-2 could be guided by the distribution of epitopes, not only on the receptor binding domain (RBD) of the Spike (S) protein, but also across the full Spike (S) protein. | 2020-06-23 |
| 32571847 | This requires attention to culturally safe care in the following interlinked areas: palliative care, communication and decision support and advanced care planning. | 2020-06-23 |
| 32571972 | Baseline characteristics, clinical presentation, management of immunosuppressive therapy and outcomes were collected. 57 patients were included (70% male, median (IQR) age at diagnosis 65 (57-70) years). 21 (37%), 32 (56%) and 21 (37%) patients had one cardiovascular disease, arterial hypertension and diabetes mellitus, respectively. | 2020-06-26 |
| 32572325 | Management of a difficult airway caused by pathology below the glottis is high-risk and requires a shared approach to airway planning and surgical treatment. | 2020-06-24 |
| 32572334 | Finding an influential treatment strategy against COVID-19 can be facilitated through better understanding of the virus pathogenesis and consequently interrupting the biochemical pathways that the virus may play role in human body as the current reservoir of the virus. | 2020-06-24 |
| 32572338 | We next evaluated the impact of repeated VHP treatment on physical features, permeability, and fabric integrity of coveralls and N-95 masks. […] Further, repeated VHP treatment did not result in any physical tear, deformity or other appreciable change in the coverall and N-95 masks. […] There was no change in user comfort and experience following VHP treatment of PPE. […] VHP treatment did not damage coveralls, cause physical deformity and also did not alter fabric architecture of melt blown layer. | 2020-06-24 |
| 32572350 | Alongside ICU nurses, physicians, and respiratory therapists, hospital pharmacists have been part of the COVID-19 efforts and their roles include management of drug shortages, development of treatment protocols, participation of patient rounds, interpretation of lab results for COVID-19, participant recruitment for clinical trials, exploration of new drugs, medication management advice, and antimicrobial stewardship. | 2020-06-24 |
| 32572376 | However, empirical therapy is being followed to manage and save the lives of the patients. | 2020-06-24 |
| 32572809 | The correct sentence should be “In this retrospective study, we included 550 critically ill COVID-19 patients who need mechanical ventilation (63.5%) and oxygen therapy (35.6%) in Tongji Hospital, Wuhan, from February 1, 2020 to April 4, 2020.” 2. | 2020-06-25 |
| 32572816 | The pandemic of COVID-19 presents an unprecedented challenge to identify effective prevention and treatment. | 2020-06-25 |
| 32572835 | Various clinical presentations have been reported so far and no definite therapy is established. | 2020-06-25 |
| 32573311 | Knowledge of those most at risk is integral for treatment, guideline implementation and resource allocation. | 2020-06-23 |
| 32573353 | We aimed to describe epidemiological features and clinical course in a large urban center to inform prevention and treatment of imported epidemics. Methods We retrospectively analyzed data collected at Shanghai Public Health Clinical Center, between January 20 and February 29, 2020. Results Among 325 cases admitted, median age was 51 years and 47.4% (154/325) had visited Wuhan within 2 weeks of illness onset. […] Half required oxygen therapy and 7.1% high-flow nasal oxygen (HFNO); median time from onset to oxygen therapy and HFNO was 7 and 9 days. […] The case fatality rate was 0.92% with median time from onset to death of 16 days. Conclusion COVID-19 cases in Shanghai were imported, presenting as viral pneumonia with half of cases needing oxygen therapy. | 2020-06-23 |
| 32573355 | It is concluded that Raltegravir and Maraviroc which may be used in the treatment of COVID-19 after Invitro and invivo studies and clinical trial for final confirmation of drug effectiveness.Communicated by Ramaswamy H. | 2020-06-25 |
| 32573419 | Blocking excessive IL-6 production might be the key to the COVID-19-ARDS treatment. […] Patients with increasing O2 requirements, within the window of opportunity for TCZ treatment (Day 7 to Day 17 after onset of symptoms) were treated with TCZ (2 infusions of 8 mg/kg). […] In patients with COVID-19 acute respiratory distress syndrome, treatment with TCZ resulted in favourable evolution in 75% of the cases. | 2020-06-23 |
| 32573538 | The article provides a review of foreign literature for 2020 on existing methods of drug treatment of coronavirus disease COVID-19. […] To date, in the treatment of COVID-19 in different countries, a little more than 10 drugs are used. […] It should be noted that among these drugs there is not a single new drug developed specifically for the treatment of COVID-19, the recommended and used drugs have previously been used to treat, as a rule, diseases of the viral etiology, less often another pathology. | 2020-06-24 |
| 32573551 | Finally, the document was approved by the National Boards of the Italian Society of Anesthesia and Intensive Care (SIAARTI), Italian Association of Critical Care Nurses (Aniarti), Italian Society of Emergency Medicine (SIMEU), and Italian Society of Palliative Care (SICP). | 2020-06-26 |
| 32573724 | To comprehensively evaluate the effectiveness, safety, and indications of convalescent plasma transfusion (CPT) therapy for severe or critical COVID-19 patients, we analyzed the clinical, laboratory, and radiologic characteristics of 1,568 patients from a single center, in which 138 patients received ABO-compatible CPT. […] 2.2% and 4.1% of cases died in the CPT group and in the standard-treatment group, respectively. […] 2.4% and 5.1% of patients in the CPT and the standard-treatment group have been admitted to ICU eventually. 70% of the patients who had severe respiratory symptoms got improved and removed oxygen supports within 7 days after CPT. […] Our study will provide important information for the clinical practice in COVID-19 treatment, as well as provide real-world observations and clinical data for the development of monoclonal antibodies. | 2020-06-23 |
| 32573737 | In this review, we review the cardiovascular manifestations of COVID-19 and describe our system-wide adaptations to the pandemic, including the use of telemedicine, how a severe reduction in operative volume affected our programme, the process of redeployment of staff, repurposing of residents into specific task teams, the creation of operation room intensive care units, and the challenges that we faced in this process. | 2020-06-23 |
| 32573776 | Clinical parameters relating to cancer history (type and treatment) and COVID-19 were collected. […] A total of 37 patients (34.6%) were receiving active anticancer treatment when diagnosed with COVID-19, whereas 70 patients (65.4%) were on follow-up. […] Overall, 52.3% of patients (56 patients) developed severe COVID-19; this rate was found to be higher among patients receiving anticancer treatment than those on follow-up (64.9% vs 45.7%), which corresponded to an inferior OS in the former subgroup of patients (hazard ratio, 3.365; 95% CI, 1.455-7.782 [P = .005]). […] The detrimental effect of anticancer treatment on OS was found to be independent of exposure to systemic therapy (case fatality rate of 33.3% [systemic therapy] vs 43.8% [nonsystemic therapy]). […] This risk is aggravated by simultaneous anticancer treatment and portends for a worse survival, despite treatment for COVID-19. | 2020-06-23 |
| 32573882 | Significant controversies exist regarding treatment modalities for this novel disease, especially in immunocompromised patients. […] Over the course of follow up, 23 have been discharged home with a functioning allograft and in stable condition; 4 experienced acute kidney injury requiring renal replacement therapy; 7 patients were intubated and 6 expired. | 2020-06-23 |
| 32573919 | In this article, we will discuss the potential phototherapy problems and also alternative options for dermatologists, ultraviolet treatment against covid-19 virus, vitamin D-associated problems in these coronavirus days. | 2020-06-23 |
| 32573921 | He successfully cleared the virus with treatment and was very compliant with his surveillance ultrasounds for hepatocellular carcinoma (HCC). | 2020-06-23 |
| 32574131 | A significant change was also observed in delaying the timing for monitoring therapy with CDK4/6 inhibitors, assessing treatment response with imaging tests, and flushing central venous devices. […] Although most of the changes in their attitudes and practice were reasonable responses to the current health care emergency without expected major negative impact on patient outcomes, some potentially alarming signals of undertreatment were observed. | 2020-06-23 |
| 32574196 | The presence of these variants in the VRC suggests a promising model for SARS-CoV-2 infection and vaccine and therapy development. | 2020-06-27 |
| 32574236 | Despite promising preventive measures being taken, there is no vaccine or drug therapy officially approved to prevent or treat the infection. | 2020-06-23 |
| 32574237 | Adaptive clinical trials with parallel enrollment to different arms each evaluating a rationally designed combination modality could provide the foundation for the accelerated identification of effective and safe multi-modality treatment algorithms for COVID-19 pneumonia. | 2020-06-23 |
| 32574243 | If the current pandemic is unprecedented, the grief following the coronavirus outbreak is likely to share features with grief related to natural disasters and after Intensive Care Unit (ICU) treatment. […] The aim of this paper is to review the most prominent literature on CG after natural disasters, as well as after diseases requiring ICU treatment. | 2020-06-23 |
| 32574255 | We compared the clinical course and outcomes of COVID-19, SARS, and MERS in pregnancy and discussed several drugs for the treatment of COVID-19 in pregnancy. | 2020-06-23 |
| 32574258 | Currently, no vaccine or treatment is available to control this pandemic. | 2020-06-26 |
| 32574260 | Therefore, further understanding of the host immune response to SARS-CoV-2 is extremely important for clinical resolution and saving medication cost. […] This may provide guidance over using immune therapy as a combined treatment to prevent patients developing severe respiratory syndrome and largely reduce complications. | 2020-06-26 |
| 32574261 | Currently, the lock down imposed by many governments is an important measure to contain the spread, as there is no specific antiviral therapy or a vaccine and the main treatments are supportive. | 2020-06-26 |
| 32574262 | We describe here the effects of treatment with interferon (IFN)-α2b in a cohort of confirmed COVID-19 cases in Wuhan, China. […] Treatment with IFN-α2b with or without arbidol significantly reduced the duration of detectable virus in the upper respiratory tract and in parallel reduced duration of elevated blood levels for the inflammatory markers IL-6 and CRP. […] These findings suggest that IFN-α2b should be further investigated as a therapy in COVID-19 cases. | 2020-06-26 |
| 32574263 | Numerous clinical trials of mesenchymal stromal/stem cells (MSCs) as a new treatment for coronavirus-induced disease (COVID-19) have been registered recently, most of them based on intravenous (IV) infusion. […] There is no approved effective therapy for COVID-19, but MSC therapies have shown first promise in the treatment of acute respiratory distress syndrome (ARDS) pneumonia, inflammation, and sepsis, which are among the leading causes of mortality in COVID-19 patients. […] While the need for MSC therapy in COVID-19 is apparent, integrating both innate and adaptive immune compatibility testing into the current guidelines for cell, tissue, and organ transplantation is critical for safe and effective therapies. […] We here propose three steps to mitigate the risk for these vulnerable patients: (1) updated clinical guidelines for cell and tissue transplantation, (2) updated minimal criteria for characterization of cellular therapeutics, and (3) updated cell therapy routines reflecting specific patient needs. | 2020-06-26 |
| 32574265 | These drugs include therapeutics with potential to inhibit SARS-CoV-2 entry into host cells such as serine protease inhibitors of the cellular protease TMPS2 and drugs targeting the renin-angiotensin system; antivirals with potential to block SARS-CoV-2 replication or factors that could boost the antiviral response; monoclonal antibodies targeting pro-inflammatory cytokines that drive the hyperinflammatory response during COVID-19 progression toward the severe stage and therapeutics that could ameliorate the function of the lungs. […] Furthermore, in order to help make more informed decisions on the timing of the intervention with the drugs listed in this review, we have grouped these therapeutics according to the stage of COVID-19 progression that we considered most appropriate for their mechanism of action. | 2020-06-26 |
| 32574277 | An ongoing challenge is to determine the optimal treatment duration to find the balance between efficacy, toxicity and cost. […] From the onset of ICPI trials, different durations were used, ranging from treatment until progression or toxicity, to fixed durations of 2 years. […] Here, we will discuss current data regarding ICPI treatment duration and incorporate this into the context of the ongoing pandemic. […] We conclude with a discussion of pragmatic approaches, should physicians be unable to continue standard therapy. | 2020-06-23 |
| 32574278 | Lymphoma patients need to be distinguished from the general population because of their deficient immune status and intensive anti-tumor treatment. […] The impacts of cancer subtypes and treatment on COVID-19 infection are unclear. Case Presentation: We here report the case of a primary mediastinal large B-cell lymphoma patient who was infected with COVID-19 after intensive immunochemotherapy (DA-EPOCH-R). […] With treatment with Arbidol Hydrochloride and LianHuaQingWen capsule, his COVID-19 was cured. Conclusions: To the best of our knowledge, this is the first report focusing on COVID-19 infection in a lymphoma patient undergoing intensive immunochemotherapy. […] The impacts of anti-cancer treatment on COVID-19 infection need to be explored further. | 2020-06-23 |
| 32574283 | The health, social, and economic impacts of the pandemic are dramatic, and vaccines or specific treatment options are not yet available. | 2020-06-26 |
| 32574284 | For three of the five patients, the primary onset disease required an emergency operation or treatment, and included intussusception, acute suppurative appendicitis perforation with local peritonitis, and traumatic subdural hemorrhage with convulsion, while for the other two it was acute gastroenteritis (including one patient with hydronephrosis and a stone in his left kidney). | 2020-06-23 |
| 32574286 | The management and treatment strategies have also been improved, which we believe would be helpful to pediatric series in other countries as well. | 2020-06-23 |
| 32574287 | There is no specific treatment for the disease, but hemodynamic stabilization of the infant, respiratory management and other daily care are essential. | 2020-06-23 |
| 32574291 | The newly emerging virus brings with it uncertainty-not only regarding its behavior and transmission dynamics but also regarding the current lack of approved antiviral therapy or vaccines-and this represents a major challenge for decision makers at various levels and sectors. | 2020-06-23 |
| 32574292 | Currently, there are no specific antiviral drugs for the treatment of COVID-19. […] This article reviews the epidemiology, pathogenesis, clinical manifestations, diagnosis, and treatment methods of severe COVID-19 and puts forward some tentative ideas, aiming to provide some guidance for the diagnosis and treatment of severe COVID-19. | 2020-06-23 |
| 32574299 | There are no treatment options available for the virus as such, limited to the use of anti-HIV drugs and/or other antivirals such as Remdesivir and Galidesivir. | 2020-06-23 |
| 32574309 | Participants were enrolled from patients presenting at the Chongqing Public Health Medical Treatment Center from Jan 24 to Feb 7, 2020, and were confirmed as having COVID-19. Results: A total of 114 COVID-19 patients (99 mild, 4 severe, 11 critical) of which 56 (56/114; 49.1%) were male, 58 (58/114; 50.9%) were female with a mean age of 46.05 years. | 2020-06-23 |
| 32574312 | Benefits of chloroquine and hydroxychloroquine for the treatment of COVID-19 infection have been proposed and clinical trials are underway. […] Chloroquine and hydroxychloroquine, typically used for the treatment of malaria and autoimmune diseases, have been considered for off-label use in several countries. […] The characteristics of sensorineural hearing loss and/or tinnitus after chloroquine or hydroxychloroquine treatment can be temporary but reports of persistent auditory and vestibular dysfunction exist. […] Additionally, abnormal cochleovestibular development in the newborn was also reported after chloroquine treatment in pregnant women. […] The suggested dose of chloroquine for COVID-19 infection is considerably higher than the usual dosage for malaria treatment; therefore, it is plausible that the ototoxic effects will be greater. | 2020-06-23 |
| 32574317 | A number of medicines are currently under investigation for the treatment of COVID-19 disease including anti-viral, anti-malarial, and anti-inflammatory agents. […] There are currently 17 clinical trials evaluating the therapeutic potential of MSCs for the treatment of COVID-19, the majority of which are administered intravenously with only one clinical trial testing MSC-derived exosomes via inhalation route. […] While we wait for the outcomes from these trials to be reported, here we emphasize opportunities and risks associated with these therapies, as well as delineate the major roadblocks to progressing these promising curative therapies toward mainstream treatment for COVID-19. | 2020-06-23 |
| 32574318 | Clinical signs, treatment, and prevention characteristics of the novel coronavirus pneumonia have been receiving attention worldwide, especially from medical personnel. […] Our report provides important information for current clinicians, for the prevention and treatment of COVID-19 pneumonia. | 2020-06-23 |
| 32574327 | New drugs and vaccines are being designed as COVID-19 treatment, but their development and testing will require months to years. […] Here, we suggest melatonin be given consideration for prophylactic use or treatment alone or in combination with other drugs. | 2020-06-23 |
| 32574328 | The objective of this systematic review was to characterize the clinical, diagnostic, and treatment characteristics of hospitalized patients presenting with COVID-19. Methods: We conducted a structured search using PubMed/Medline, Embase, and Web of Science to collect both case reports and case series on COVID-19 published up to April 24, 2020. […] The most commonly used antiviral treatment modalities included, lopinavir (HIV protease inhibitor), arbidiol hydrochloride (influenza fusion inhibitor), and oseltamivir (neuraminidase inhibitor). Conclusions: Development of ARDS may play a role in estimating disease progression and mortality risk. […] There is currently not a well-established gold standard therapy for the treatment of diagnosed COVID-19. | 2020-06-23 |
| 32574337 | This paper reports the clinical characteristics, diagnosis, and treatment of the first critical COVID-19 patient in Liaocheng City, who was admitted to the intensive care unit isolation ward of Liaocheng People’s Hospital on February 11, 2020. […] After comprehensive treatment including high-flow nasal cannula oxygen therapy, plasma exchange, antiviral and anti-infection therapies, immune regulation, liquid volume management, glucocorticoid, enteral nutrition support, analgesia and sedation, blood glucose control, anticoagulation and thrombus prevention, and electrolyte balance maintenance, the patient was finally cured, and discharged. […] The purpose of this case report is to provide a reference for the clinical diagnosis and treatment of critical COVID-19 patients. | 2020-06-23 |
| 32574338 | Multiple strategies would be highly necessary to handle the current outbreak; these include computational modeling, statistical tools, and quantitative analyses to control the spread as well as the rapid development of a new treatment. | 2020-06-23 |
| 32574340 | Chinese herbal medicine (CHM) was also included as part of the treatment plans at various stages of COVID-19. Methods: We conducted a pilot randomized, controlled trial in patients with severe COVID-19 in Wuhan, China. […] The primary outcome was the change in the disease severity category of COVID-19 after treatment. Results: Between Jan 31, 2020, and Feb 19, 2020, 42 out of 100 screened patients were included in the trial: 28 in the CHM plus standard care group and 14 in the standard care alone group. […] For the primary outcome, one patient from each group died during treatment; the odds of a shift toward death was lower in the CHM plus group than in the standard care alone group (common OR 0.59, 95% CI 0.148-2.352, P = 0.454). […] After treatment, mild, moderate, and severe COVID-19 disease accounted for 17.86% (5/28) vs. […] 7.14% (1/28) of the patients treated with CHM plus standard care vs. standard care alone. Conclusions: For the first time, the G-CHAMPS trial provided valuable information for the national guideline-based CHM treatment of hospitalized patients with severe COVID-19. | 2020-06-23 |
| 32574346 | About 70.9% of outpatients had to postpone their mental health treatment; 43.2% of patients admitted that their mental health was adversely affected by the COVID-19 outbreak-these patients tended to be older, male and less educated. | 2020-06-23 |
| 32574408 | In addition to the economic and social damage caused by COVID-19 outbreak prolongation, damage caused by delayed treatment of other diseases such as severe cirrhosis is also serious. | 2020-06-23 |
| 32574432 | Recently the internet has been abuzz with new ideas to treat COVID-19, including hyperbaric oxygen (HBO2) therapy, undoubtedly driven by the fact that until recently there have been few therapeutic options for this highly contagious and often lethal infection. . . . | 2020-06-23 |
| 32574433 | To determine whether hyperbaric oxygen (HBO2) therapy be effective to improve hypoxemia for severe COVID-19 pneumonia patients. […] Patients were treated with 1.5 atmospheres absolute HBO2 with an oxygen concentration of more than 95% for 60 minutes per treatment, once a day for one week. […] For both patients, dyspnea and shortness of breath were immediately alleviated after the first HBO2 treatment and remarkably relieved after seven days of HBO2 therapy. […] Our preliminary uncontrolled case reports suggest that HBO2 therapy may promptly improve the progressive hypoxemia of patients with COVID-2019 pneumonia. […] However, the limited sample size and study design preclude a definitive statement about the potential effectiveness of HBO2 therapy to COVID-2019 pneumonia. | 2020-06-23 |
| 32574446 | The UHMS Hyperbaric Oxygen Therapy Committee, UHMS Executive Committee, with collaborative input from multiple senior UHMS members and researchers have drafted this position statement. | 2020-06-23 |
| 32574702 | A cross-sectional study was conducted between Jan. 1st, and Feb. 30th, 2020, where front line members of medical staff that took part in the care and treatment of patients with COVID-19 were enrolled. | 2020-06-23 |
| 32574789 | At baseline, all patients had multiple biological abnormalities (lymphopenia, increased CRP, ferritin, fibrinogen, D-dimer and liver enzymes). 24 patients (70.5%) recovered after TCZ therapy and 10 died (29.5%). […] Deceased subjects differed from patients in whom treatment was effective with regard to more pronounced lymphopenia (0.6 vs 1.0 G/l; p = 0.037), lower platelet number (156 vs 314 G/l; p = 0.0001), lower fibrinogen serum level (0.6 vs 1.0 G/l; p = 0.03), higher aspartate-amino-transferase (108 vs 57 UI/l; p = 0.05) and greater O2 requirements (11 vs 8 l/min; p = 0.003). | 2020-06-27 |
| 32574894 | A significant proportion of COVID 19 sufferers are asymptomatic, but shedding these viral particles, PVP-I has been shown to be a safe therapy when used as a mouthwash or taken nasally or used during ophthalmic surgeries. | 2020-06-25 |
| 32574956 | We report the fundamental pathological investigation in the lungs and other organs of fatal cases for the mechanistic understanding of severe COVID-19 and the development of specific therapy in these cases. | 2020-06-26 |
| 32574982 | We aimed to study lifestyle changes and other common issues related to treatment in our previously seen and treated patients with T2DM. | 2020-06-26 |
| 32575019 | Pirfenidone is approved for the treatment of Idiopathic Pulmonary Fibrosis (IPF) for patients with mild to moderate disease. […] Based on the pirfenidone mechanism of action and the known pathophysiology of COVID-19, I believe that pirfenidone has the potential for the treatment of COVID-19 patients. | 2020-06-26 |
| 32575124 | Tocilizumab (anti-IL-6R) is FDA-approved for treatment of cytokine storm associated with chimeric antigen receptor T-cell therapy. […] We examined clinical and laboratory parameters including oxygen and vasopressor requirements, cytokine profiles, and C-reactive protein (CRP) levels pre- and post-tocilizumab treatment. […] IL-6 was the predominant cytokine detected at tocilizumab treatment. […] The rationale for tocilizumab treatment is supported by detection of IL-6 in pathogenic levels in all patients. | 2020-06-23 |
| 32575350 | We underscore the potential benefits of conducting a randomized open-label unblinded clinical trial to evaluate the role of ursodeoxycholic acid (UDCA) in the treatment of COVID-19. […] UDCA is an existing drug with proven safety profiles that can reduce inflammation and prevent cell death. National Geographic reported that, “China Promotes Bear Bile as Coronavirus Treatment”. | 2020-06-24 |
| 32575380 | In March 2020, the World Health Organization (WHO) declared Coronavirus Disease 2019 (COVID-19) a pandemic, therefore the efforts of scientists around the world are focused on finding the right treatment and vaccine for the novel disease. […] The aim of this narrative review is to present the possible causes and pathophysiology of pulmonary fibrosis associated with COVID-19 based on the mechanisms of the immune response, to suggest possible ways of prevention and treatment. | 2020-06-24 |
| 32575476 | Until now, no precise treatment modality has been developed. […] Next, we found that treatment with citronellol and limonene significantly downregulated ACE2 expression in epithelial cells. | 2020-06-24 |
| 32576057 | On April 6, 2020, the Child Neurology Society issued an online statement of immediate recommendations to streamline diagnosis and treatment of infantile spasms with utilization of telemedicine, outpatient studies, and selection of first-line oral therapies as initial treatment. | 2020-06-26 |
| 32576319 | Based on these considerations we would hold that telepsychiatry is a vital aspect of providing psychiatric care, and ethically should be offered as a format for treatment, likely beyond the pandemic period. | 2020-06-25 |
| 32576325 | This article discusses how the Palliative Care Team of the Komfo Anokye Teaching Hospital in Ghana has modified its services in accordance with public health guidelines. […] It also suggests a strategy to deal with palliative care needs of critically ill patients with COVID-19 and their families. | 2020-06-24 |
| 32576328 | According to this classification, risk management was based on a treatment flowchart for tailored clinical decisions-making. | 2020-06-24 |
| 32576343 | The COVID-19 TCM treatment plan and syndrome related literature published before February 24, 2020 was searched and a database was established. […] Forty-two literatures about treatment plans, and 212 syndromes records were enrolled. | 2020-06-24 |
| 32576345 | To investigate the clinical characteristics and CT imaging features of patients with different clinical types of coronavirus disease 2019 (COVID-19), so as to provide a reference for the treatment and evaluation of COVID-19. | 2020-06-24 |
| 32576357 | It is speculated that RAS imbalance plays an important role in the development of multi-organ dysfunction caused by 2019-nCoV, and the usage of angiotensin converting enzyme inhibitor/angiotensin II receptor blocker (ACEI/ARB) may become a new treatment of 2019-nCoV-related organ injury. | 2020-06-24 |
| 32576358 | Continuous renal replacement therapy (CRRT) has become an effective multiple organ support therapy instead of single renal replacement as initially expected, and it is widely used in intensive care unit (ICU). […] Accordingly, the paper aims to elaborate the similarities and differences between CRRT in COVID-19 and routine treatment in terms of safety and accessibility, indications and timing, clinical operation, anticoagulation, fluid management, prevention and control of infectious diseases, etc. | 2020-06-24 |
| 32576359 | This article reviews the mechanism, clinical significance, understanding of TCM and common methods of promoting blood circulation and removing blood stasis caused by 2019-nCoV, in order to provide ideas for the prevention and treatment of impaired blood coagulation in patients with COVID-19. | 2020-06-24 |
| 32576530 | Although urologists are less involved in the direct treatment of COVID-19 patients, the current situation strongly affects the urological work routine. | 2020-06-24 |
| 32576608 | It is a balancing act: limited resources and a hostile environment pitted against the time-sensitive nature of cancer treatment. | 2020-06-24 |
| 32576712 | Covariates were lymphocyte count, serum levels of albumin, C-Reactive Protein, D-Dimers and Lactate Dehydrogenase (LDH), anticoagulation level, and exposure to the hydroxychloroquine and azithromycin combined therapy. | 2020-06-24 |
| 32576980 | Therapeutics against coronavirus disease 2019 (COVID-19) are urgently needed. | 2020-06-26 |
| 32577056 | To describe and establish role of Nrf2 activators for treatment COVID-19 positive patients. […] We used method of analysis of the published papers with described studies about COVID-19 connected with pharmacological issues and aspects which are included in global fighting against COVID-19 infection, and how using DMF (Nrf2 activator) in clinical trial for nCOVID-19 produce positive effects in patients for reduce lung alveolar cells damage. we are found that Nrf2 activators an important medication that’s have a role in reduce viral pathogenesis via inhibit virus entry through induce SPLI gene expression as well as inhibit TRMPSS2, upregulation of ACE2 that’s make a competition with the virus on binding site, induce gene expression of anti-viral mediators such as RIG-1 and INFs, induce anti-oxidant enzymes, also they have a role in inhibit NF-κB pathway, inhibit both apoptosis proteins and gene expression of TLRs. | 2020-06-25 |
| 32577236 | Selecting specific pharmacological targets for the treatment of viral pathogens has traditionally relied in blockage of specific steps in their replicative lifecycle in human cells. | 2020-06-25 |
| 32577324 | At present, there is a substantial amount of research being done to discover suitable treatment modalities. | 2020-06-25 |
| 32578027 | Till now, there has not been any specific treatment found for this virus. | 2020-06-26 |
| 32578070 | From home to intensive care units, innovations in pulse oximetry are susceptible to improve the monitoring and management of patients developing acute respiratory failure, and particularly those with the coronavirus disease 2019 (COVID-19). […] Tracking changes in the peripheral perfusion index during a preload-modifying maneuver may be useful to predict preload responsiveness and rationalize fluid therapy. | 2020-06-26 |
| 32578156 | The exposure of interest was lopinavir-ritonavir treatment in severe COVID-19 compared to standard of care, placebo or other treatments. | 2020-06-26 |
| 32578309 | Careful dermatological examination improves diagnostic accuracy in skin disorders and skin manifestations of COVID-19 infection that provides an early diagnosis and treatment, helps to improve the quality of the patient care and management. | 2020-06-24 |
| 32578683 | The aim of this meta-analysis was to calculate the prevalence and geographical distribution of comorbidities in all patients admitted to intensive care units (ICUs), and the mortality rate of COVID-19. | 2020-06-24 |
| 32578694 | We present an experience report on the implementation of real-time telehealth in speech-language and hearing therapy for patients who were previously seen on an outpatient basis in a primary health care service. […] The Speech-Language Therapy (SLT) team was monitoring twenty-five users when the first cases of COVID-19 were notified in southern Brazil. | 2020-06-24 |
| 32578696 | The COVID-19 Pandemic has resulted in a high number of hospital admissions and some of those patients need ventilatory support in intensive care units. | 2020-06-24 |
| 32578784 | The main measures used by physiotherapists to monitor their patients at a distance included: written treatment prescription (38%), making explanatory videos (26.7%), and synchronous video conference treatment (23.5%). […] Our data revealed that most of the physiotherapists interrupted their face-to-face practices because of the COVID-19 pandemic, however, once they do not follow up their patients’ treatment in person, most of them adapted to monitor their patients from a distance. | 2020-06-24 |
| 32578785 | Approximately 5% of the patients will require intensive care unit treatment with oxygen therapy and mechanical ventilation. […] Limited data are available about rehabilitation protocols for severe illness and intensive care treatment of COVID-19 increase. | 2020-06-24 |
| 32578790 | Radiologic findings, fluid therapy, hemodynamic support, use of inotropic/vasopressors, nutritional therapy, antiviral therapy, corticosteroids, antithrombotic therapy, and immunoglobulins are analyzed to guide all professionals during hospitalization. | 2020-06-24 |
| 32578794 | In severe cases, the use of medications such as hydroxychloroquine and azithromycin or medication can be promising. | 2020-06-24 |
| 32578820 | There is no specific vaccine or medication available. […] Treatment is supportive and nonspecific. | 2020-06-24 |
| 32578825 | On the basis of the opinions of front-line experts and a review of the relevant literature on several topics, we proposed clinical practice recommendations on the following aspects for physiotherapists facing challenges in treating patients and containing virus spread: 1. personal protective equipment, 2. conventional chest physiotherapy, 3. exercise and early mobilization, 4. oxygen therapy, 5. nebulizer treatment, 6. non-invasive ventilation and high-flow nasal oxygen, 7. endotracheal intubation, 8. protective mechanical ventilation, 9. management of mechanical ventilation in severe and refractory cases of hypoxemia, 10. prone positioning, 11. cuff pressure, 12. tube and nasotracheal suction, 13. humidifier use for ventilated patients, 14. methods of weaning ventilated patients and extubation, and 15. equipment and hand hygiene. | 2020-06-24 |
| 32578826 | Pulmonary ultrasonography can also be an auxiliary method, especially for monitoring hospitalized patients in intensive care units, where transfer to a tomography scanner is difficult. | 2020-06-24 |
| 32578829 | Patients with lung cancer are at risk of pulmonary complications from COVID-19, and as such, the risk/benefit ratio of local and systemic anticancer treatment has to be considered. […] For each patient, several factors, including age, comorbidities, and immunosuppression, as well as the number of hospital visits for treatment, can influence this risk. […] In this regard, the Brazilian Thoracic Oncology Group has developed recommendations to guide decisions in lung cancer treatment during the SARS-CoV-2 pandemic. […] Due to the scarcity of relevant data, discussions based on disease stage, evaluation of surgical treatment, radiotherapy techniques, systemic therapy, follow-up, and supportive care were carried out, and specific suggestions issued. […] All recommendations seek to reduce contagion risk by decreasing the number of medical visits and hospitalization, and in the case of immunosuppression, by adapting treatment schemes when possible. | 2020-06-24 |
| 32578893 | As a leader in SOT, we recognized the need to enhance patient engagement by implementing a comprehensive pharmacist-driven medication knowledge program encompassing didactics, visual tools and virtual learning. | 2020-06-24 |
| 32579059 | Recently Chloroquine and its derivative Hydroxychloroquine have garnered enormous interest amongst the clinicians and health authorities’ world over as a potential treatment to contain COVID-19 pandemic. | 2020-06-24 |
| 32579064 | COVID-19 has ravaged the world and is the greatest of pandemics in human history, in the absence of treatment or vaccine the mortality and morbidity rates are very high. | 2020-06-24 |
| 32579067 | How high these numbers will eventually go depends on many factors, including policies on travel and movement, availability of medical support, and, because there is no vaccine or highly effective treatment, the pace of biomedical research. | 2020-06-24 |
| 32579195 | To evaluate the effect of treatment with colchicine on cardiac and inflammatory biomarkers and clinical outcomes in patients hospitalized with coronavirus disease 2019 (COVID-19). […] In this prospective, open-label, randomized clinical trial (the Greek Study in the Effects of Colchicine in COVID-19 Complications Prevention), 105 patients hospitalized with COVID-19 were randomized in a 1:1 allocation from April 3 to April 27, 2020, to either standard medical treatment or colchicine with standard medical treatment. […] Colchicine administration (1.5-mg loading dose followed by 0.5 mg after 60 min and maintenance doses of 0.5 mg twice daily) with standard medical treatment for as long as 3 weeks. | 2020-06-27 |
| 32579254 | All eight compounds can combine well with NSP12-NSP7-NSP8 in the crystal structure, providing drug candidates for the treatment and prevention of COVID-19 and SARS. | 2020-06-24 |
| 32579293 | 82.7% received antiviral therapy, but such therapy did not shorten virus negative time or hospital stay (P=0.082). […] Children with SARS-CoV-2 infection had a mild fever, lymphocyte elevation was more common than reduction, antiviral treatment had no obvious effect. | 2020-06-24 |
| 32579597 | This retrospective case-control study was aimed at identifying potential independent predictors of severe/lethal COVID-19, including the treatment with Angiotensin-Converting Enzyme inhibitors (ACEi) and/or Angiotensin II Receptor Blockers (ARBs). […] At multivariate analysis, no association was observed between therapy and disease severity (Adjusted OR for very severe/lethal COVID-19: 0.87; 95% CI: 0.50-1.49). […] No association was found between COVID-19 severity and treatment with ARBs and/or ACEi, supporting the recommendation to continue medication for all patients unless otherwise advised by their physicians. | 2020-06-24 |
| 32579707 | Numerous drugs are being investigated for the treatment of COVID-19, including antivirals and therapies targeting complications related to COVID-19. […] This review offers key clinical pharmacology considerations involved in the development of small molecules for the treatment of COVID-19. | 2020-06-24 |
| 32579957 | In this context, special attention should be given towards COVID-19 patients with concurrent cardiovascular diseases, and special cardiovascular attention is warranted for treatment of COVID-19. | 2020-06-26 |
| 32579986 | A subgroup of COVID-19 patients develop very severe disease with requirement for ICU treatment, ventilation, and ECMO therapy. | 2020-06-26 |
| 32580130 | Thus, numerous recommendations and therapeutic options have been reported to optimize therapy delivery to patients with chronic disease and cancer. […] In this review, we aimed to summarize these international guidelines in accordance with cancer types, making a synthesis for daily practice to protect patients, staff and tailor anti-cancer therapy delivery taking into account patients/tumour criteria and tools availability. | 2020-06-26 |
| 32580131 | Overall, 8 of 85 oncology health professionals tested positive for SARS-CoV-2 infection (all but one employed in the COVID Unit, no hospital admissions and no treatment required); among 471 patients admitted for SARS-CoV-2 infection, 7 had an “active”’ oncological disease (2 died of infection-related complications). | 2020-06-26 |
| 32580215 | We believe that the clinical course and pathology findings obtained after right pneumonectomy in a patient with pre-symptomatic COVID-19 pneumonia will guide the diagnosis and treatment of patients infected with SARS-CoV-2. | 2020-06-24 |
| 32580256 | We report a case that presented to and was managed in our Sioux Falls pediatric intensive care unit in April 2020 that fits the description, course, and successful treatment described by our European colleagues. […] We will review and discuss the European and US case definitions of this syndrome and similarities, and differences with Kawasaki disease and treatment options. | 2020-06-24 |
| 32580257 | Treatment for ARDS in the setting of SARS-CoV-2 should follow pre-established goals of care and the wishes of the patient and family members or caregivers and consider the high risk for polypharmacy, cognitive decline, malnutrition, and depression, particularly in older adults. […] Treatment recommendations have outlined ventilation goals to minimize further lung injury. | 2020-06-24 |
| 32580258 | Based on the most recently published evidence, this article will review and discuss comprehensive information on its clinical manifestations, laboratory tests, potential therapeutics, and prevention guidelines. | 2020-06-24 |
| 32580641 | During COVID-19 pandemic, cancer patients are considered one of the most vulnerable to infection since they tend to have advanced age, multiple comorbidities, and are often immunosuppressed by their cancer or therapy. […] Hence, the Saudi Oncology Pharmacy Assembly has issued recommendations to reduce the frequency of cancer patients’ visits to oncology centers during the pandemic while maintaining the access to cancer therapy and minimize the risk of exposure to coronavirus disease. […] On that basis, the panelists developed eight practice-related recommendations for action, with a main focus on cancer treatment modification. […] The SOPA expert panel developed these recommendations, to ultimately contribute in maintaining access to cancer therapy while minimizing the risk of COVID-19 exposure. | 2020-06-25 |
| 32580752 | No effective antiviral treatment has been proved thus far. […] Traditional Chinese medicine (TCM) has been widely applied in the treatment of a variety of infection diseases in China, hoping to produce clinical effects and reduce the use of antibiotics and glucocorticoid. […] The aim of this study is to evaluate the efficacy and safety of Shenhuang granule in treatment of severe COVID-19. […] The participants will be randomly (1:1) divided into treatment group or control group. […] All participants are given standard therapy at the same time. […] The experiment will receive Shenhuang granule treatment twice a day for 14 days. […] The clinical indicators of patients will be assessed at baseline and at 3, 5, 7, and 14 days after treatment initiation. | 2020-06-27 |
| 32580895 | Therefore, the treatment of cytokine storm has been proposed as a critical part of rescuing severe COVID-19. | 2020-06-27 |
| 32581015 | Anticoagulant therapy, mainly with low molecular weight heparin (LMWH), appears to be associated with better prognosis in patients with severe COV-ID-19. […] Markedly elevated D-Dimer can be used to guide the introduction of anticoagulation therapy and evaluate prognosis of COVID-19. | 2020-06-25 |
| 32581016 | Epidemiological, clinical, laboratory, and treatment data were collected and analyzed. […] After the treatment, the counts of white blood cells and platelets, and the level of prealbumin increased significantly, while aspartate aminotransferase (AST), lactate dehydrogenase (LDH), and hsCRP decreased. | 2020-06-25 |
| 32581017 | This suggests that a targeted therapy could address the biology of COVID-19 pneumonia, enhance the host immune response and prevent its progression to a life-threatening, ventilator-dependent clinical situation. | 2020-06-25 |
| 32581069 | Within this framework, it is crucial to ensure no disruption to essential oncological services and guarantee the optimal care.This is a structured proposal for the management of lung cancer, comprising three levels of priorities, namely: tier 1 (high priority), tier 2 (medium priority) and tier 3 (low priority)-defined according to the criteria of the Cancer Care Ontario, Huntsman Cancer Institute and Magnitude of Clinical Benefit Scale.The manuscript emphasises the impact of the COVID-19 pandemic on lung cancer care and reconsiders all steps from diagnosis, staging and treatment.These recommendations should, therefore, serve as guidance for prioritising the different aspects of cancer care to mitigate the possible negative impact of the COVID-19 pandemic on the management of our patients.As the situation is rapidly evolving, practical actions are required to guarantee the best patients’ treatment while protecting and respecting their rights, safety and well-being. | 2020-06-25 |
| 32581323 | Population-based studies from China and Italy suggested a higher coronavirus disease 2019 (COVID-19) death rate in patients with cancer2,3, although there is a knowledge gap as to which aspects of cancer and its treatment confer risk of severe COVID-194. […] This information is critical to balance the competing safety considerations of reducing SARS-CoV-2 exposure and cancer treatment continuation. […] Age older than 65 years and treatment with immune checkpoint inhibitors (ICIs) were predictors for hospitalization and severe disease, whereas receipt of chemotherapy and major surgery were not. | 2020-06-25 |
| 32581514 | Among all trials, 27.9% of the studies used traditional Chinese medicine (TCM), 10.3% used cell therapy, and 5.0% used plasma therapy. […] This study is the first snapshot of the landscape of COVID-19 clinical trials registered in China and provided the basic features of clinical trial designs for the treatment and prevention of COVID-19 to offer useful information to guide future clinical trials on COVID-19 in other countries. | 2020-06-26 |
| 32581809 | This commentary elaborates on the pharmacological rationale of repositioning the mast cell stabilizer chromones as an adjunctive treatment for SARS-CoV-2 infection, and proposes their practical clinical testing as an early, safe, and cost-effective anti-inflammatory intervention in COVID-19 to limit the eventual secondary progression toward life-threatening respiratory complications. | 2020-06-26 |
| 32581810 | To date, there are no specific therapeutic strategies for treatment of COVID-19. […] Based on the hypothesis that complement and coagulation cascades are activated by viral infection, and might trigger an acute respiratory distress syndrome (ARDS), we report clinical outcomes of 17 consecutive cases of SARS-CoV-2-related ARDS treated (N = 7) with the novel combination of ruxolitinib, a JAK1/2 inhibitor, 10 mg/twice daily for 14 days and eculizumab, an anti-C5a complement monoclonal antibody, 900 mg IV/weekly for a maximum of three weeks, or with the best available therapy (N = 10). […] Patients treated with the combination showed significant improvements in respiratory symptoms and radiographic pulmonary lesions and decrease in circulating D-dimer levels compared to the best available therapy group. […] Our results support the use of combined ruxolitinib and eculizumab for treatment of severe SARS-CoV-2-related ARDS by simultaneously turning off abnormal innate and adaptive immune responses. | 2020-06-26 |
| 32581816 | Mechanical respirator devices are the most widely applied therapy for ARDS in COVID-19, yet mechanical ventilation achieves strikingly poor survival. | 2020-06-27 |
| 32582134 | The communication between the microbiota and SARS-CoV-2 and the role of this association in diagnosis and treatment are unclear. | 2020-06-26 |
| 32582321 | With no available vaccine, the treatment is primarily symptomatic for those affected and preventative for those at risk. | 2020-06-26 |
| 32582324 | There is no evidence-based treatment for the infection and prevention of transmission using social distancing, isolation and hygiene measures is widely recommended. | 2020-06-26 |
| 32582330 | Without effective treatment, it is imperative to take precautionary measures. | 2020-06-26 |
| 32582375 | Considering this, a careful consideration for treatment management of different malignancies is required. | 2020-06-26 |
| 32582382 | To explore safe delays for the treatment of common paediatric orthopaedic conditions when faced with a life-threatening pandemic, COVID-19, and to propose a categorization system to address this question. […] Review of the literature related to acceptable delays for treatment of common orthopaedic conditions, experience of healthcare professionals from low resource communities and expertise of experienced surgeons. | 2020-06-26 |
| 32582401 | Hence, they are potential candidate agents for treatment of severe cases of COVID-19. […] Finally, we report the potential of MSC and exosome therapy in severe cases of COVID-19 in recently initiated or planned clinical trials of MSCs (33 trials) and exosomes (1 trial) registered in 13 countries on ClinicalTrials.gov. | 2020-06-26 |
| 32582489 | In light of the patient’s poor clinical status, age, and significant comorbidities, prognosis was conveyed about medical futility and patient’s family agreed to terminal extubation and the patient expired peacefully, exactly one week from hospital admission. | 2020-06-26 |
| 32582574 | As such, it is now receiving renewed attention as a potential target for anti-viral therapeutics. | 2020-06-27 |
| 32582575 | According to scoring system, the probability of patients in high risk group developing severe disease was 20.24 times than that in low risk group. Conclusions: The possibility of severity in COVID-19 infection predicted by scoring system could help patients to receiving different therapy strategies at a very early stage. Topic: COVID-19, severe and fetal pneumonia, logistic regression, scoring system, prediction. | 2020-06-26 |
| 32582576 | More importantly, although modulation of ACE2 will certainly not provide a cure for the COVID-19 disease, modulation of ACE2 by sex hormone modulators, if they affect the expression of ACE2, could potentially be developed into a supportive therapy for COVID-19 patients. | 2020-06-26 |
| 32582740 | Most patients (23/29; 79.8%) received supplemental oxygen therapy and antibiotics (23/29; 79.8%) in addition to traditional Chinese medicines (26/29; 89.7%). […] Need of oxygen therapy, mechanical ventilation, intravascular immunoglobulin, and duration of antibiotic therapy were increased in those with severe disease. Conclusions: Significant differences in demographical and clinical characteristics were observed in patients with moderate and severe COVID-19. | 2020-06-26 |
| 32582745 | Transfusion dependent patients require regular monitoring for iron overload, and iron chelation therapy may be stopped by the physician depending on the situation. | 2020-06-26 |
| 32582747 | Poor responses from the authorities to the spread of infection, lack of effective measures for prevention, unavailability of promising treatment options, and sufficient diagnostic options have created an alarming for the world. […] Implementing proper strategies addressing the infection control and clinical supplies, understanding the mechanism associated with pathogenesis, advancing in preventive measures and effective treatment and diagnostic options are necessary to control the ongoing pandemic. | 2020-06-26 |
| 32582818 | Given that the United States has the greatest number of positive coronavirus cases, it is likely that many, if not all, radiation oncology clinics will be faced with the challenge of safely balancing a patient’s risk of contracting COVID-19, while under active radiation treatment, against their risk of cancer progression if treatment is delayed. […] To address this challenge, the New York Proton Center established an internal algorithm that considers treatment-related, tumor-related, and patient-related characteristics. […] Despite having suffered staff shortages due to illness, this algorithm has allowed the center to maintain patient treatment volumes while keeping the rate of COVID-19 infection low. | 2020-06-26 |
| 32583086 | This review also highlights potential targets for prevention and therapy of COVID-19-related organ damage and discusses the role of marketed drugs, such as eculizumab and imatinib, as suitable candidates for clinical trials. | 2020-06-27 |
| 32583172 | Results highlighted coordination of resources, essential services and treatment, data collection, communication among public health and healthcare systems, and dissemination of information. | 2020-06-27 |
| 32583216 | Half of responders modified their approach to intra-abdominal infections towards a more conservative treatment. 43% of responders, mainly in the North, were shifted to assist non-surgical patients. | 2020-06-27 |
| 32583289 | When conducting clinical trials under COVID-19 pandemic, protocol deviations and/or protocol violations are inevitably encountered due to possible environment change which may have an impact on the accuracy and reliability of clinical evaluation of the test treatment under investigation. […] Protocol deviations and/or violations include, but are not limited to, eligibility criteria, testing procedure, dose and dose regiment, treatment duration and clinical operation of the intended trial. | 2020-06-27 |
| 32583353 | In addition, the hybrid compounds, such as COX-2 inhibitors/TP antagonists, can be an innovative treatment to control the overall balance between AA mediators in patients with COVID-19. | 2020-06-27 |
| 32583423 | However, we caution how government failure to account for structural inequalities can alienate vulnerable groups, inhibit groups from being able to follow guidance, and lead to the creation of new groups in response to illegitimate treatment. | 2020-06-25 |
| 32583465 | Columbia University Irving Medical Center/NewYork-Presbyterian Hospital (CUIMC/NYPH) had to make changes to its cellular therapy operations to ensure patient, donor, and staff safety and well-being. […] In this article, we discuss the process changes we instituted for cellular therapy clinical care, collection, processing, and cryopreservation to cope with the rapidly evolving pandemic. | 2020-06-25 |
| 32583525 | This contingency guide was formulated on the premise that delivering standard treatment for hepatocellular carcinoma (HCC) has come under strain due to the COVID-19 pandemic. | 2020-06-25 |
| 32583538 | I believe that the risk of bringing this virus into our study ecosystems is too great and that primatologists should cancel all field research until the pandemic ends or a vaccine/reliable treatment is widely available. | 2020-06-25 |
| 32583620 | All five patients were on immunosuppressive therapy with mycophenolate mofetil (MMF) and tacrolimus and three that were transplanted within the prior two months were additionally on prednisone. | 2020-06-25 |
| 32583640 | Various drugs are involved in the treatment plan and are often known to fail. […] All in all, we continue to wander in the dark, both about the disease and certainly, regarding the treatment. […] The primary treatment involves maximum efforts for respiratory, hematologic, nephrologic and cardiologic support. | 2020-06-25 |
| 32583671 | In our experience, permanent tracheostomy did not significantly affect the choice of treatment. […] However, dedicated devices and repeated tracheal toilettes may be needed to deal with oxygen-therapy-related tracheal crusting. | 2020-06-25 |
| 32583680 | Recommendations are provided according to each clinical situation: patients undergoing treatment, new cases, hospitalized patients, palliative care and surveillance. | 2020-06-27 |
| 32583751 | Local, regional, and national government actions taken to mitigate the spread of COVID-19 have thus served, in part, to shield older adults from the virus, though not without adverse side effects, including increased social isolation, enhanced economic risk, revealed ageism, delayed medical treatment, and challenges getting basic needs met. | 2020-06-25 |
| 32584062 | Third, the article discusses key opportunities for improvement in HSP education and training, including more effective use of competency evaluations; distance technologies in therapy, supervision, and admissions; and reconsideration of internship and degree timing and HSP’s identity as a health care profession; and the potential for comprehensive review and redesign of HSP education and training. | 2020-06-25 |
| 32584101 | Integrated primary care settings are ideal locations for treatment of posttraumatic stress concerns as primary care is the principal access point for mental health treatment in the United States. | 2020-06-25 |
| 32584106 | The spread of coronavirus disease 2019 (COVID-19) has placed many individuals in need of critical care, with a high proportion of hospitalized patients being admitted to intensive care units (ICU) to treat acute outcomes of COVID-19 (e.g., respiratory failure via mechanical ventilation). | 2020-06-25 |
| 32584199 | Clinical trials for therapeutics and vaccine development should include paediatric considerations. | 2020-06-25 |
| 32584236 | In this narrative review, the Turkish Thoracic Society Early Career Taskforce members aimed to provide a summary on recent literature regarding epidemiology, clinical findings, diagnosis, treatment, prevention, and control of COVID-19. […] Despite these efforts, we still have much to learn regarding the transmission, treatment, and prevention of COVID-19. | 2020-06-26 |
| 32584322 | The ideal treatment of coronavirus disease (COVID)-19 has yet to be defined, but convalescent plasma (CoPla) has been successfully employed. | 2020-06-26 |
| 32584326 | The objective of the study to describe the clinical features of COVID-19 patients diagnosed in a tertiary-care center in Mexico City and to assess differences according to the treatment setting (ambulatory vs. hospital) and to the need of intensive care (IC). […] Twenty-nine (20.7%) inpatients required treatment in the IC unit (ICU). | 2020-06-26 |
| 32584416 | 6-8) Based on the success of IL-6 receptor blockade for chimeric antigen receptor T-cell therapy associated cytokine release syndrome (CAR T-cell CRS), similar strategies using tocilizumab are being investigated in COVID-19. | 2020-06-25 |
| 32584418 | The optimal treatment for patients with newly diagnosed acute myeloid leukaemia (AML) who are infected with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2)/COVID-19 is unknown.1 We report the case of a previously fit 27-year-old male who presented with a 3-day history of fever (>39 C), swollen, erythematous elbows and no respiratory symptoms. | 2020-06-25 |
| 32584421 | (5-7) Ruxolitinib (RXB), a JAK-STAT inhibitor, has also been shown to have proven efficacy in the treatment of sHLH. | 2020-06-25 |
| 32584441 | There is an urgent need of unbiased expert knowledge guiding the development of efficient treatment and prevention strategies. | 2020-06-25 |
| 32584474 | Current therapeutic options are limited and there is no registered and/or definite treatment or vaccine for this disease or the causative infection, severe acute respiratory coronavirus 2 syndrome (SARS-CoV-2). | 2020-06-25 |
| 32584604 | That is because it is rapid and easily accessible and helpful for monitoring patient progress during treatment. | 2020-06-25 |
| 32584762 | The cause of acute respiratory failure is a massive hyperinflammation in the lungs, and treatment with glucocorticoids is not recommended by the WHO. […] Janus kinase (JAK) 1/2 inhibitor treatment is highly efficacious in HLS. | 2020-06-25 |
| 32584894 | For planning of treatment capacities, it is of major importance to obtain reliable information on infection and fatality rates of the novel coronavirus. | 2020-06-25 |
| 32584978 | The hub-and-spoke organization system efficiently safeguards access to heart and vascular surgical services for patients who require ND, urgent and emergency treatment. | 2020-06-25 |
| 32585074 | Lastly, other skin manifestations to be considered are the cutaneous adverse reactions to the drugs prescribed for the treatment of COVID-19. | 2020-06-25 |
| 32585135 | There are as yet no licensed therapeutics for the COVID-19 pandemic. | 2020-06-27 |
| 32585136 | Clinical scenarios covering the use of pharmacological treatment for COVID-19 in the case of liver derangement, and assessment and management of patients with chronic hepatitis B or hepatitis C, non-alcoholic fatty liver disease, liver cirrhosis, and liver transplantation during the pandemic are discussed. | 2020-06-27 |
| 32585284 | A total of 31 COVID-19 patients were included with an overall mean age of 51 ± 15 years (range: 27-76 years), 90% (n = 28) were males, and 35% (n = 11) of the patients had TPE as a mode of treatment. | 2020-06-27 |
| 32585435 | The implementation of the algorithm is designed to mitigate COVID-19 transmission, preserve the safest and least restrictive treatment environment for psychiatric inpatients, and provide a model adaptable to other institutional settings. | 2020-06-27 |
| 32585497 | In summary, we recommend the screening of every single person accessing the treatment room, the consideration of hypofractionation and to delay postoperative RT for non-small cell lung cancer, to avoid twice-daily treatments and delay or deliver prophylactic cranial irradiation during radio(chemo)therapy for limited-stage small cell lung cancer, review image guided RT images for suspicious image findings, and the use of single-fraction RT for the palliative treatment of stage IV lung cancer patients. | 2020-06-27 |
| 32585765 | High-flow nasal cannula oxygen therapy was required on day 4-5 of hospitalization. […] Symptoms of pneumonia were improved which no oxygen treatment required from day 10 of hospitalization. […] Drug interaction between tacrolimus and anti-viral treatment lead to severely high level of tacrolimus which caused reversible acute kidney injury (AKI) after supportive treatment. | 2020-06-25 |
| 32585805 | Currently, no definitive treatment or prevention therapy exists for COVID-19. […] The unprecedented rise of this pandemic has rapidly fueled research efforts to discover and develop new vaccines and treatment strategies against this novel coronavirus. […] While hundreds of vaccines/therapeutics are still in the preclinical or early stage of clinical development, a few of them have shown promising results in controlling the infection. […] Here, in this review, we discuss the promising vaccines and treatment options for COVID-19, their challenges, and potential alternative strategies. | 2020-06-26 |
| 32586154 | Montelukast can be effective in the treatment of SARS-CoV-2 infection. | 2020-06-26 |
| 32586156 | Despite the direct effect on the routine of all life aspects, there are no clinical guidelines regarding phototherapy treatment during COVID-19 pandemic and as a result, phototherapies units continued to deliver this therapy for patients worldwide.Objective: We wish to explore the phototherapy utilization among dermatologic patients.Methods: We marked all patients that continue to arrive and being treated during COVID-19 pandemic.Results: From March more than 50% of patients stopped arriving to treatments due to the fear of COVID-19 infection.Conclusions: COVID-19 has a major implication on chronic dermatology treatments such as phototherapy. | 2020-06-26 |
| 32586214 | The growing awareness and mechanistic understanding of the prothrombotic state of COVID-19 patients is driving efforts to more stringent diagnostic screening for thrombotic compli¬cations and to the early institution of antithrombotic drugs, for both the prevention and therapy of thrombotic complications. […] The shifting paradigm of diagnostic and treatment strategies holds significant promise to reduce the burden of thrombotic complications and ultimately improve the prognosis for patients with COVID-19. | 2020-06-26 |
| 32586363 | Patients with acute lymphoid and myeloid leukemias in the first line treated with curative intent, patients with high-grade non-Hodgkin’s lymphoma treated with leukemia protocols and patients with non-metastatic breast and colon cancer in the first line of treatment will enter the study. […] During two months of treatment, the two groups are treated with either hydroxychloroquine (Amin® Pharmaceutical Company, Isfahan, Iran) or placebo (identical in terms of shape, colour, smell) as a single 200 mg tablet every other day. […] This trial has been registered by the title of “Effect of Hydroxychloroquine on Novel Coronavirus Disease (COVID-19) prevention in cancer patients under treatment” in Iranian Registry of Clinical Trials (IRCT) with code “IRCT20200405046958N1”, https://www.irct.ir/trial/46946. | 2020-06-28 |
| 32586380 | We applied two computational approaches to identify potential therapeutics. | 2020-06-28 |
| 32586394 | Concomitant anticoagulant treatment for other indications (e.g. atrial fibrillation, venous thromboembolism, prosthetic heart valves) 10. […] Concomitant double antiplatelet therapy 11. […] This dose is commonly used in Italy when a bridging strategy is required for the management of surgery or invasive procedures in patients taking anti-vitamin K oral anticoagulants Body Weight (kg)Enoxaparin dose every 12 hours (IU)<50200050-69400070-89600090-1108000>11010000 The treatment with Enoxaparin will be initiated soon after randomization (maximum allowed starting time 12h after randomization). […] The treatment will be administered every 12 hours in the intervention group and every 24 hours in the control group. […] Need of either: a.Continuous Positive Airway Pressure (Cpap) or Non-Invasive Ventilation (NIV) orb.IMV in patients who at randomisation were in standard oxygen therapy by delivery interfaces5. […] Need of either: a.Continuous Positive Airway Pressure (Cpap) or Non-Invasive Ventilation (NIV) orb.IMV in patients who at randomisation were in standard oxygen therapy by delivery interfaces5. | 2020-06-28 |
| 32586395 | On home/therapy oxygen (i.e. for patients with Chronic Obstructive Pulmonary Disease) at baseline prior to development of CoViD-193. […] If shortness of breath (SOB) persists 20 minutes after the start of the first treatment, a second dose will be administered. […] Max doses per day is 9 or 18 stimulations.Plus standard of care Control: Standard of care: oxygen therapy, antibiotics and ventilatory support if necessary depending on the clinic MAIN OUTCOMES: Primary Endpoint: Initiation of mechanical ventilation, from randomization until ICU admission or hospital discharge, whatever occurs first Secondary Endpoints: Safety; ascertainment of Adverse Effects/Serious Adverse Events, from randomisation to ICU admission or hospital discharge, whatever occurs firstCytokine Storm measured by: Tumor necrosis factor α, Interleukin 6, Interleukin 1β. | 2020-06-28 |
| 32586396 | Approximately 8 - 10 % of COVID-19 patients present with a serious clinical course and need for hospitalization, 8% of hospitalized patients need ICU-treatment. […] Currently, no causal therapy is available and treatment is purely supportive. […] However, in a number of patients a severe hyperinflammatory response with excessively elevated proinflammatory cytokines causes vasoplegic shock resistant to vasopressor therapy. […] Patients are recruited from the Intensive Care Units (ICUs) of 7 participating centers in Germany (approximately 10 ICUs). […] Patients are included irrespective of indication for renal replacement therapy. […] Within 24 hours after meeting the inclusion criteria patients will be randomized to receive either standard of care or standard of care and additional “CytoSorb” therapy via a shaldon catheter for 3-7 days. […] If patients receive antibiotics, an additional dose of antibiotics is administered after each change of “CytoSorb” filter in order to prevent underdosing due to “CytoSorb” treatment. | 2020-06-28 |
| 32586399 | Thus, TH may be a novel treatment in the setting of critical illness due to viral infection in which hypoxia prevails. […] Patients will be excluded in cases of pregnancy, severe systemic disease with life expectancy less than 6 months, participation in another trial of an investigational drug or device, corticosteroid and/or sympathomimetic use before initiation of treatment. […] A 1:1 treatment allocation will be adopted. […] Triiodothyronine for the Treatment of Critically Ill Patients With COVID-19 Infection (Thy-Support), ClinicalTrials.gov Identifier: NCT04348513, date of trial registration: April 16, 2020, EudraCT Identifier: 2020-001623-13, date of trial registration: April 22, 2020 FULL PROTOCOL: The full protocol is attached as an additional file, accessible from the Trials website (Additional file 1). | 2020-06-28 |
| 32586628 | We consider implications of the pandemic for people with obesity in relation to: difficulties in managing hospitalized patients, implications of confinement for the control and treatment of obesity, and the stigma people with obesity suffer, that could increase should the relationship between obesity and COVID-19 be confirmed. | 2020-06-28 |
| 32586678 | Reliable circuits for staff as well as for patients are installed and treatment protocols are adapted to the current COVID-19 situation. | 2020-06-28 |
| 32586724 | Previous studies have suggested a more frequent and severe course of novel coronavirus SARS-CoV-2 infection in cancer patients undergoing active oncologic treatment. […] Cancer patients under active treatment admitted for SARS-CoV-2 infection have worse outcomes in terms of mortality and respiratory failure rates compared with COVID-19 global population. | 2020-06-28 |
| 32586839 | We aimed to study predictors of in-hospital death, characteristics of arrhythmias and the effects of QT-prolonging therapy in patients with cardiac injury. […] We determined that patients who received QT-prolonging drugs had longer QTc intervals than those who did not receive them (difference in medians, 45 ms, p = 0.01), but such treatment was not independently associated with mortality (HR 1.04, 95% CI 0.69-1.57). […] Patients with COVID-19 warrant assessment for cardiac injury and monitoring, especially if therapy that can prolong repolarization is started. | 2020-06-26 |
| 32586885 | The epidemiology, immunology of these viral infections and their interactions with TB are discussed with implications on diagnosis, treatment and prevention of airborne infections (infection control, viral containment and workplace safety). | 2020-06-26 |
| 32586933 | Immunomodulatory therapy (IMT) is often considered for systemic treatment of non-infectious uveitis (NIU). […] Highest consensus was achieved for not initiating IMT in patients who have suspected or confirmed COVID-19, and for using local over systemic corticosteroid therapy in patients who are at high-risk and very high-risk for severe or fatal COVID-19. […] While there was a consensus in starting or initiating NSAIDs for the treatment of scleritis in healthy patients, there was no consensus in starting hydroxychloroquine in any risk groups. […] Consensus guidelines were proposed based on global expert opinion and practical experience to bridge the gap between clinical needs and the absence of medical evidence, to guide the treatment of patients with NIU during the COVID-19 pandemic. | 2020-06-28 |
| 32587063 | Employing this methodology against MS2 phage, a highly conservative surrogate for SARS-CoV-2 contamination, we report an average 6-log10 plaque-forming unit (PFU) (99.9999%) and a minimum 5-log10 PFU (99.999%) reduction after a single 3-min microwave treatment. | 2020-06-26 |
| 32587152 | Suspension of oncology services will have major implications on cancer care due to delayed diagnosis and treatment leading to irreversible adverse consequences. | 2020-06-26 |
| 32587157 | Though tele-ophthalmology has been popular for screening, there are no clear guidelines on how to comprehensively manage patients seeking advice and treatment for a particular eye condition. | 2020-06-26 |
| 32587169 | About 40% required physical examination, mostly due to uncertain diagnosis (22%) or inadequate response to prescribed treatment (19%). | 2020-06-26 |
| 32587649 | Despite reported observational data about the experimental use of certain drugs, there is no conclusively proven curative therapy for COVID-19 as of now; however, remdesivir received emergency use authorization (EUA) by the Food and Drug Administration (FDA) recently for use in patients hospitalized with COVID-19. […] There are several ongoing clinical trials related to the pharmacological choices of therapy for COVID-19 patients; however, drug trials related to observational studies so far have yielded mixed results and therefore have created a sense of confusion among healthcare professionals (HCPs). […] In this review article, we seek to collate and provide a summary of treatment strategies for COVID-19 patients with a variable degree of illness and discuss pharmacologic and other therapies intended to be used either as experimental medicine/therapy or as part of supportive care in complicated cases of COVID-19. | 2020-06-27 |
| 32587651 | Continuous renal replacement therapy (CRRT) is the most used blood purification technique when needed. | 2020-06-27 |
| 32587806 | With no standard of care for the treatment of COVID-19, there is an urgent need to identify therapies that may be effective in treatment. […] Here we provide a systematic review of the available literature and an impetus for further research on the use of Gal-3 inhibitors in the treatment of COVID-19. […] Further, we propose a dual mechanism by which Gal-3 inhibition may be beneficial in the treatment of COVID-19, both suppressing the host inflammatory response and impeding viral attachment to host cells. | 2020-06-27 |
| 32587886 | In light of the available literature regarding the pro-thrombotic effects of this novel corona virus, we continued full dose anticoagulation with Enoxaparin after the cardiac catheterization and transitioned to rivaroxaban and we also continued the patient on dual antiplatelet therapy prior to discharge. | 2020-06-28 |
| 32588061 | Most (some 80%) cases of COVID‑19 infection are asymptomatic, a substantial number of cases (15%) require hospitalization and an additional fraction of patients (5%) need recovery in intensive care units. | 2020-06-26 |
| 32588105 | The establishment of centers dedicated to COVID-19 treatment and care also necessitates preparation of the surgical departments for the forthcoming emergency interventions for infected patients and patients with an unclear infection status. | 2020-06-28 |
| 32588163 | Based on the promising role of cell therapy and regenerative medicine approaches in the treatment of several life-threatening diseases, it seems that applying cell-based approaches can also be a hopeful strategy for improving subjects with severe acute respiratory infections caused by the 2019 novel coronavirus. […] Herein, due to the amazing effects of mesenchymal stem cells in the treatment of various diseases, this review focuses on the auxiliary role of mesenchymal stem cells to reduce inflammatory processes of acute respiratory infections caused by the 2019 novel coronavirus. | 2020-06-28 |
| 32588213 | Triage measures for patients who visit respiratory clinics, quality control for pediatric respiratory clinics and other preventive measures for related examinations and treatment have been introduced in this review article. | 2020-06-28 |
| 32588427 | Before therapy initiation, a baseline 12 lead-ECG was electronically sent to our cardiology department for automated and manual QT analysis (Bazett and Fridericia’s correction), repeated 2 days after initiation. […] Baseline average automated QTc was 415 ± 29 ms and lengthened to 438 ± 40 ms after 48 hours of combined therapy. […] The treatment had to be stopped because of significant QTc prolongation in 2 out of 71 patients (2.8 %). | 2020-06-26 |
| 32588493 | Restoring lipoprotein function with ApoA-I raising agents or blocking relevant scavenger receptors with neutralizing antibodies could, therefore, be of value in the treatment of COVID-19. | 2020-06-26 |
| 32588499 | Increasing activity levels should be prioritized as a treatment target, especially when the barriers to exercise are greater than ever. […] We present theoretical perspectives and therapy techniques relating to (1) beliefs about physical activity, (2) motivation to be physically active, and (3) the sense of reward achieved through being physically active. | 2020-06-26 |
| 32588530 | The race for a vaccine against SARS-CoV-2 has accelerated research on RNA-based therapeutics. | 2020-06-26 |
| 32588590 | The development of host-directed antiviral therapy seems to be a promising way to treat infections with SARS-CoV or other pathogenic coronaviruses. | 2020-06-26 |
| 32588748 | A retrospective review of the electronic patient record of 61 hospital inpatients referred to the specialist palliative care team with swab-confirmed COVID-19 who subsequently died over a 1-month period. […] In seven of eight patients where higher doses were prescribed, this was on specialist palliative care team advice. […] Prescription of end-of-life symptom control drugs for COVID-19 fell within the existing guidance when supported by specialist palliative care advice. | 2020-06-26 |
| 32588801 | Based on the results of Least Absolute Shrinkage and Selection Operator (LASSO) logistic regression, age, and suggestive chest X-ray (CXR) findings for SARS-CoV-2 infection, cardiovascular diseases, diabetes mellitus, chronic lung diseases, and intensive care units admission had significant associations with positive RT-PCR results for COVID-19 infection. | 2020-06-26 |
| 32588943 | Although epidemiological and clinical characteristics of Covid-19 have been constantly reported, no article has systematically illustrated the role of obesity and diabetes in Covid-19, or how Covid-19 affects obesity and diabetes, or special treatment in these at-risk populations. […] Here, we present a synthesis of the recent advances in our understanding of the relationships between obesity, diabetes and Covid-19 along with the underlying mechanisms, and provide special treatment guidance for these at-risk populations. | 2020-06-26 |
| 32589042 | Remote therapy has been used by analytic therapists for quite some time, though many have been reluctant to use it regularly, out of concern that it might distort analytic frame and relational dynamics. […] Now the Covid-19 pandemic has forced therapists to make a sudden, across-the-board transition to remote therapy. […] This study reports on survey responses from 190 analytic therapists on their transition to online therapy via videoconferencing during the pandemic and their previous experience with remote therapy (the majority had such experience). […] Moreover, despite technical and relational challenges, they remained as strong, emotionally connected, and authentic in their online therapy sessions as they were in person. […] These experiences during the pandemic led to more positive views of online therapy than they held before, but a majority still considered online therapy less effective than in-person sessions. | 2020-06-26 |
| 32589054 | While we and our patients have many transferences to the modality of video or telephone therapy, these meanings are ultimately not intrinsic to the medium itself. […] This paper discusses the symbolic meanings that we attribute to teletherapy and the ways we may use these attributed meanings to dissociate the trauma of Covid-19. | 2020-06-26 |
| 32589146 | One trial reported that remdesivir was superior to placebo in shortening the time to recovery, while the other two showed no benefit of the treatment under investigation. | 2020-06-26 |
| 32589149 | The main specific factors of increase in C/S food intake (n=10,771) were female gender (aOR=1.62; 95%CI=1.48-1.77), being aged less than 29 years (p-values<0.001), having a partner (aOR=1.19; 95%CI=1.06-1.35), being locked down in a more confined space (per one m2/person decrease: aOR=1.02; 95%CI=1.01-1.03), being locked down alone (aOR=1.29; 95%CI=1.11-1.49), and reporting a current (aOR=1.94; 95%CI=1.62-2.31) or past (aOR=1.27; 95%CI=1.09-1.47) psychiatric treatment. […] The main specific factors of increase in alcohol use (n= 7,108) were being aged 30-49 years (p-values <0.05), a high level of education (p-values <0.001), or a current psychiatric treatment (aOR=1.44; 95%CI=1.10-1.88). | 2020-06-26 |
| 32589165 | Since the beginning of the outbreak of severe acute respiratory syndrome (SARS) coronavirus (CoV) 2 lopinavir/ritonavir was selected for treatment. […] The recent publication of Cao et al in the NEJM[1] showed that lopinavir/ritonavir treatment did not accelerate clinical improvement compared with standard of care. | 2020-06-26 |
| 32589265 | The challenges for family therapists, whose practices are confined largely to online therapy, and who are struggling with the same fears and constraints as those persons they are attempting to help, are also discussed. | 2020-06-26 |
| 32589267 | The issues discussed in this paper are specific to the United States despite their relevance to family therapy as a field. | 2020-06-26 |
| 32589449 | Background: There is currently no effective treatment against coronavirus disease 2019 (COVID-19). […] Therefore, evidence from randomized controlled trials (RCTs) to support specific treatment against COVID-19 is urgently needed. […] The use of Chinese herbal medicines (CHMs) might have a role in the treatment and symptomatic management of patients with COVID-19. […] It was aimed at providing an overview of the available evidence and ongoing trials concerning the effects of CHMs for the treatment of COVID-19. Methods: This is a narrative review of relevant studies. […] Electronic databases, evidence-based collections, websites of relevant organizations, and trial registries were consulted. Results: A total of 25 guidelines on the treatment of patients with COVID-19 were identified. […] No finished RCTs of CHMs for the treatment of patients with COVID-19 was found. […] A total of 52 ongoing clinical trials of CHM interventions for the treatment of COVID-19 were found. […] Forty-seven trials (90%) will have a sample size <400 participants. Conclusions: To the authors’ knowledge, only the Chinese and the South Korean guidelines recommend CHMs as a treatment option for patients with COVID-19. […] Due to the absence of RCT, there is currently no reliable evidence on the effects of any specific CHM intervention for the treatment of patients with COVID-19. | 2020-06-26 |
| 32589451 | The incidence and severity of coronavirus disease 2019 (COVID-19) among HIV-positive persons receiving antiretroviral therapy (ART) have not been characterized in large populations. | 2020-06-26 |
| 32589531 | Patients with mild disease can now be managed in the outpatient setting and with newly developed therapies, such as catheter-directed thrombolysis, becoming available in more centres, treatment options for those with more severe disease are also expanding. | 2020-06-26 |
| 32589691 | Additionally, patients who underwent at least one of the following treatments were assigned to the severe group: continuous renal replacement therapy, high-flow oxygen absorption, noninvasive and invasive mechanical ventilation, or extracorporeal membrane oxygenation. | 2020-06-26 |
| 32589718 | This article describes COVID-19 as the next historical turning point in the physical therapy profession’s growth and development. […] ARDS is well familiar to physical therapists in intensive care units. | 2020-06-26 |
| 32589775 | RDV received FDA’s emergency use authorization in United States and approval in Japan for treatment of severe COVID-19 patients. | 2020-06-26 |
| 32589897 | All the three proteins showed strong inhibition on type I interferon (IFN-β) and NF-κB-responsive promoter, further examination revealed that these proteins were able to inhibit the interferon-stimulated response element (ISRE) after infection with Sendai virus, while only ORF6 and ORF8 proteins were able to inhibit the ISRE after treatment with interferon beta. | 2020-06-28 |
| 32589990 | In that same scenario, postponement or interruption of radiotherapy treatment of COVID-19 positive patients is generally recommended to avoid exposure of cancer patients and staff to an increased risk of COVID-19 infection. […] Case-specific consensus recommendations regarding multimodality treatment strategies and fractionation of radiotherapy are provided. | 2020-06-26 |
| 32590117 | Specialized iNO machines can now be developed to provide the drug intermittently in short bursts at high concentration dose, which would then provide both a preventative drug for those at high risk, as well as an effective treatment, without the health hazards associated with smoking. | 2020-06-26 |
| 32590314 | Laboratory blood tests delay is associated with the type of treatment. | 2020-06-26 |
| 32590324 | Pharmacologic inhibitors or antibodies specific to adenosinergic pathway components or adenosine receptors in microbial and tumor therapy have shown efficacy in pre-clinical studies and are entering the clinical arena. […] In this review, we provide a novel hypothesis explaining the potential for improving the efficiency of innate and adaptive immune systems by targeting adenosinergic pathway components and adenosine A2A receptor signaling for the treatment of COVID-19. | 2020-06-28 |
| 32590779 | This case indicated that the comprehensive measures performed by a multidisciplinary team achieved good treatment effects on a COVID-19 patient with diabetes. […] Targeted treatment and nursing methods should be performed based on patients’ actual situations in clinical practice. | 2020-06-26 |
| 32591003 | There are many expediencies provided by the use of hiPSCs, which can represent a disease model clinically relevant and predictive, with a great potential if associated to CRISPR/Cas9 technology, a gene editing tool powered by ease and precision never seen before.Here, we describe the possible applications of CRISPR/Cas9 to hiPSCs: from drug development to drug screening and from gene therapy to the induction of the immunological response to specific virus infection, such as HIV and SARS-Cov-2. | 2020-06-27 |
| 32591132 | In this review, we review the cardiovascular manifestations of COVID-19 and describe our system-wide adaptations to the pandemic, including the use of telemedicine, how a severe reduction in operative volume affected our program, the process of redeployment of staff, repurposing of residents into specific task teams, the creation of operation room intensive care units, and the challenges that we faced in this process. | 2020-06-27 |
| 32591152 | The COVID-19 pandemic is changing approaches to diagnosis, treatment, and care provision in multiple sclerosis (MS). […] The purpose of this study is to present a safety algorithm enabling patients to resume pulse immunosuppressive therapy (PIT) during the easing of lockdown measures. | 2020-06-27 |
| 32591180 | In this work we aim to describe the clinical characteristics, treatment and outcome of pneumococcal infection in COVID-19 patients. […] Radiological pattern of COVID-19 can be indistinguishable from that of pneumococcus pneumonia and frequency of co-infection is not well stablished, therefore clinicians should be aware of the possible SARS-CoV-2-pneumococcus association to avoid misdiagnosis and delay antibiotic therapy. | 2020-06-27 |
| 32591185 | In view of the need to optimise the management of hypercoagulability, the working groups of the Scientific Societies of Anaesthesiology-Resuscitation and Pain Therapy (SEDAR) and of Intensive, Critical Care Medicine and Coronary Units (SEMICYUC) have developed a consensus to establish guidelines for actions to be taken against alterations in haemostasis observed in severely ill patients with COVID-19. […] These recommendations include prophylaxis of venous thromboembolic disease in these patients, and in the peripartum, management of patients on long-term antiplatelet or anticoagulant treatment, bleeding complications in the course of the disease, and the interpretation of general alterations in haemostasis. | 2020-06-27 |
| 32591283 | On the other hand, hypotheses in favour and against a deleterious effect of angiotensin converting enzyme inhibitors and angiotensin receptor blockers, a usual treatment for cardiovascular disease, have been raised. | 2020-06-27 |
| 32591393 | There are no widely available licensed therapeutics against SARS-CoV-2, highlighting an urgent need for effective interventions. | 2020-06-27 |
| 32591654 | The paper summarises the current guidelines outlined by the CDC and presents the triaging protocols to identify potential carriers and how to safely limit treatment to low-risk patients. | 2020-06-27 |
| 32591657 | With regards to previous treatment outcomes, a few systematic reviews were included, but again, the novel nature of this outbreak means that largely, there are only cohort or case studies available for review.Data extraction and synthesis There are ten authors, with no indication of how many performed the literature review or if a mediator was involved in the final decision making on what papers would be reviewed.Results Excessive consumption of alcohol, history of tobacco use, an ageing population, and comorbidities such as cardiopulmonary issues are substantial risk factors for episodes of unfavourable respiratory outcomes. | 2020-06-27 |
| 32591663 | All 48 dental hospitals suspended general non-emergency dental treatment. | 2020-06-27 |
| 32591664 | The inclusion and exclusion criteria for the data sources are not reported in the manuscript.Study selection The authors included six studies on the effectiveness of hydroxychloroquine or chloroquine for the prevention and treatment of COVID-19 in humans. […] Treatment regimens and the study outcomes were extracted where available and overall findings were presented in a table. […] Narrative synthesis of each of the included studies identified important and significant limitations, precluding the studies from demonstrating a statistically significant difference in outcomes.Conclusions This review highlights the urgent need for more high quality evidence on the use of hydroxychloroquine and chloroquine in the prevention and treatment of COVID-19. […] The authors suggested that the studies be viewed as hypothesis-generating and should not be used in decision making around the recommendations and guidelines in the prevention and treatment of COVID-19. | 2020-06-27 |
| 32591667 | Additionally, 18 guidelines about the COVID-19 were reviewed and the key points were represented in this study.Study selection The review included human trials, in-vitro studies, review articles, and credible news reports about severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and COVID-19 complications, treatment guidelines, management strategies, and epidemiological features. […] The following sequence was also suggested as early supportive therapy and monitoring: intravenous fluid administration, oxygen therapy, and application of corticosteroids. | 2020-06-27 |
| 32591704 | Seventy-six percent of patients attending met the agreed local criteria for urgent treatment, with the most common presentation being irreversible pulpitis. | 2020-06-27 |
| 32591712 | The potential for aerosol generation, the presence of the virus within saliva and the fact that dental professionals work with the oral-pharyngeal environment determines that dental treatment poses a risk of viral transmission. | 2020-06-27 |
| 32591771 | Experimental and preclinical data should be integrated into a comprehensive analysis, where drug potency, the timing of therapy initiation, drug combinations, variability in systemic and local drug exposure and short- and long-term toxicities represent fundamental factors for the rational identification of candidates and prioritization of clinical investigations. […] Although the identification of SARS-CoV-2 therapeutics is a priority, rigorous and transparent methodologies are crucial to ensure that accelerated research programmes result in high-quality and reproducible findings. | 2020-06-27 |
| 32591888 | • Compromised lung values in the 6-23% range prompt oxygenation therapy; values above 23% increase the need for intubation. | 2020-06-27 |
| 32591890 | The percentage of patients with fever, cough, shortness of breath, and myalgia obviously decreased at 7-13 days with regular treatment (p < 0.05). […] CT imaging may be indicated when patients fail to improve within a week of treatment, but repeated chest CT may be unnecessary when the patients show improvements clinically. | 2020-06-27 |
| 32591913 | Resources were redirected across all healthcare sectors to support the treatment of viral pneumonia with resultant effects on other essential services. | 2020-06-27 |
| 32591960 | The surgical treatment of femoral neck fractures showed a stable reduction from 15 to 20% without a significant variation during the timeframe. […] Covid-19 outbreak showed a tremendous impact on all orthopaedic trauma activities throughout the country except for the surgical treatment of femoral neck fractures, which, although reduced, did not change in percentage within the analysed timeframe. | 2020-06-27 |
| 32591970 | The aim of the current article is to review the growing body of knowledge on the course/management of COVID-19 in patients with inflammatory rheumatic diseases by presenting a SARS-CoV-2 infected case with ankylosing spondylitis under secukinumab therapy. […] A 61-year old patient with ankylosing spondylitis who was on secukinumab therapy for 5 months admitted with newly onset fever and gastrointestinal complaints. | 2020-06-27 |
| 32592145 | Due to the incessant spread of the disease with substantial morbidity and mortality rates, there is an urgent demand for effective therapeutics and vaccines to control and diminish this pandemic. […] Our findings suggest that computationally developed inhibitory peptide may be developed as an anti-SARS-CoV-2 agent for the treatment of SARS-CoV-2 infection. | 2020-06-27 |
| 32592163 | As no effective treatment is currently available, we propose ‘Primed’ Mesenchymal Stem Cells (MSCs) as a therapeutic alternative to tackle devastating epidemic. […] The individual response to MSCs treatment is heterogeneous. […] During the treatment of infectious pathology, the effectiveness of the treatment may vary based on the disease scenario. | 2020-06-27 |
| 32592268 | The treatment of the glabella complex not only has been shown to inhibit the negative emotions of the treated individual but also can reduce the negative in those who come in contact with the treated individual. | 2020-06-27 |
| 32592461 | We review the existing literature on COVID-19 among immunocompromised populations ranging from cancer patients and solid organ transplant recipients to patients with HIV and those receiving immunomodulatory therapy for autoimmune disease. | 2020-06-27 |
| 32592501 | Additionally, we suggest that the identification and treatment of the cytokine storm are important components for rescuing patients with severe COVID-19. | 2020-06-27 |
| 32592502 | In this study, retrospective analysis was used to explore the dynamic changes of serum IgM and IgG antibody and factors affecting diagnostic efficacy, so as to provide a theoretical basis for clinical diagnosis and treatment. | 2020-06-27 |
| 32592564 | The most studied of the physical methods that have a proven effect are physical exercises, breathing exercises, the complex effect of factors of resort therapy, hydrotherapy, which affect the main clinical manifestations of the underlying disease, astheno-neurotic syndrome and increasing immunity. […] Regular generalization and analysis of high-quality randomized controlled clinical trials to evaluate various physical methods of treatment of patients with pneumonia associated with the new COVID-19 coronavirus infection is Necessary, which serve as a basis for the development of future valid clinical recommendations. | 2020-06-27 |
| 32592657 | Statins are lipid-lowering therapeutics with favorable anti-inflammatory profiles and have been proposed as an adjunct therapy for COVID-19. […] These results give support for the completion of ongoing prospective studies and randomized controlled trials involving statin treatment for COVID-19, which are needed to further validate the utility of this class of drugs to combat the mortality of this pandemic. | 2020-06-27 |
| 32592716 | Based on this analysis, we conclude that GLR should be further considered and rapidly evaluated for the treatment of patients with COVID-19. | 2020-06-27 |
| 32592817 | In this review, we discuss the types, characteristics, antiviral mechanisms, and shortcomings of recommended candidate medicines for SARS-CoV-2 infection, as well as perspectives of the drugs for the disease treatment, which may provide a theoretical basis for drug screening and application. | 2020-06-27 |
| 32592842 | This includes drive-through screening facilities, high-speed RT-PCR technologies, convalescent patients’ plasma therapy, which potentially had some positive contributions in combatting COVID-19 in the WPR as well as globally. | 2020-06-27 |
| 32592911 | The corona virus pandemic has ignited a proliferation of research aimed at prevention of spread, early diagnosis and treatment. | 2020-06-27 |
| 32593116 | Teledentistry is the remote facilitating of dental treatment, guidance, and education via the use of information technology instead of direct face-to-face contact with patients. | 2020-06-27 |
| 32593183 | Anti-IL6 therapy has shown promise in restraining the hyperinflammatory syndrome and while IL-6 is a pleiotropic mediatory of the inflammatory response, redundancy within inflammatory pathways means that the use of such targeted monoclonal therapy may have too restricted a repertoire in some patients. […] We present the case of a 53-year-old haematopoetic stem cell transplant recipient who developed a severe COVID-19 that was refractory to anti-IL6 therapy, but responded to Jak-Stat inhibition with ruxolitinib, demonstrating its safety and efficacy in this setting. | 2020-06-27 |
| 32593196 | Delirium caused by hypoxia, a prominent clinical feature of COVID-19, may increase the need for treatment of Alzheimer’s disease (AD) patients (1). […] Therefore, drug-drug interactions should be considered in AD patients while receiving COVID-19 treatment. | 2020-06-27 |
| 32593209 | Therapy of severe COVID-19 infection has relied on supportive intensive care measures. […] Since abrupt discontinuation of ruxolitinib may cause fatal cytokine storm and ARDS, ruxolitinib treatment was continued and was well tolerated, and the patient´s condition remained stable, without the need for mechanical ventilation or vasopressors. […] In conclusion, our report provides clinical evidence that ruxolitinib treatment is feasible and can be beneficial in patients with COVID-19 pneumonia, preventing cytokine storm and ARDS. | 2020-06-27 |
| 32593339 | We explored factors associated with need for intensive care unit (ICU) admission and initiation of drug treatment for COVID-19 using univariable analysis, and applied multivariable logistic regression with backwards stepwise analysis to further explore those factors significantly associated with ICU admission. 582 individuals with PCR-confirmed SARS-CoV-2 infection were included, with a median age of 5·0 years (IQR 0·5-12·0) and a sex ratio of 1·15 males per female. 145 (25%) had pre-existing medical conditions. 363 (62%) individuals were admitted to hospital. 48 (8%) individuals required ICU admission, 25 (4%) mechanical ventilation (median duration 7 days, IQR 2-11, range 1-34), 19 (3%) inotropic support, and one (<1%) extracorporeal membrane oxygenation. […] Immunomodulatory medication used included corticosteroids (22 [4%] patients), intravenous immunoglobulin (seven [1%] patients), tocilizumab (four [1%] patients), anakinra (three [1%] patients), and siltuximab (one [<1%] patient). […] The data also reflect the current uncertainties regarding specific treatment options, highlighting that additional data on antiviral and immunomodulatory drugs are urgently needed. ptbnet is supported by Deutsche Gesellschaft für Internationale Zusammenarbeit. | 2020-06-29 |
| 32593519 | On the base of historical experiences, Convalescent Plasma (CP), a passive antibody therapy, has been evaluated as a hopeful and potential therapeutic option since the beginning of the COVID-19 outbreak. […] Immune plasma had been used previously for the treatment of H1N1 influenza virus, SARS-CoV-1 and MERS-CoV epidemics successfully. […] The first part encompasses the supply of CCP and the second part lead the clinical use of CCP for the treatment of patients with severe COVID-19 infection. […] This follow-up process is thought to be crucial for the creation and development of current and future treatment modalities. […] This guide would be a pathfinder for clinicians and/or institutions those eager to conduct CCP treatment more effectively. | 2020-06-29 |
| 32593614 | As prevention and treatment efforts continue with regard to COVID-19, the general public has developed poor sleep hygiene habits, which deserve attention. | 2020-06-29 |
| 32593740 | Irisin treatment increased by 3-fold the levels of TRIB3 transcript and decreased the levels of other genes. […] Our results, in human subcutaneous adipocytes cell culture, indicate a positive effect of irisin on the expression of multiple genes related to viral infection by SARS-CoV-2; furthermore, translatable for other tissues and organs targeted by the novel coronavirus and present, thus, promising approaches for the treatment of COVID-19 infection as therapeutic strategy to decrease ACE2 regulatory genes. | 2020-06-29 |
| 32593807 | This article has the purpose of examining the problem of getting help for the medical-psychiatric-substance use group of “homeless” people on the streets of our cities, who refuse treatment. […] It has been stalemated, in part, by advocates, who argue for personal autonomy and freedom rather than involuntary diagnosis and treatment over the life of these people. […] We review A) the nature of the problem, B) the current social-legal availability of treatment and long-term management (or lack of one) in the context of societal rejection of these potential patients, and C) suggest what might be done, locally and nationally. | 2020-06-29 |
| 32593867 | Hospitalization and early treatment with hydroxychloroquine and azithromycin (HCQ-AZ) was proposed for the positive cases. […] Treatment with HCQ-AZ was associated with a decreased risk of transfer to ICU or death (Hazard ratio (HR) 0.18 0.11-0.27), decreased risk of hospitalization ≥10 days (odds ratios 95% CI 0.38 0.27-0.54) and shorter duration of viral shedding (time to negative PCR: HR 1.29 1.17-1.42). […] QTc prolongation (>60 ms) was observed in 25 patients (0.67%) leading to the cessation of treatment in 12 cases including 3 cases with QTc> 500 ms. […] Although this is a retrospective analysis, results suggest that early diagnosis, early isolation and early treatment of COVID-19 patients, with at least 3 days of HCQ-AZ lead to a significantly better clinical outcome and a faster viral load reduction than other treatments. | 2020-06-29 |
| 32593935 | Despite many unsolved controversies in screening, treatment, and follow-up of gestational diabetes, it seems involvement with novel coronavirus have made a reach to a global agreement simpler. | 2020-06-29 |
| 32593961 | The emergency represented by the COVID-19 pandemic represents a new challenge for clinicians who deal with autoimmune diseases because of patients undergoing immunosuppressive therapy. | 2020-06-29 |
| 32594085 | Punctual and early use of HP and CRRT in the treatment of ARDS in patients with COVID-19 prevented the progression of ARDS and patient intubation, reduced respiratory distress and the patient’s dependence on oxygen, prevented other complications such as AKI and septic shock in the patient, and reduced mortality and hospital length of stay. | 2020-06-29 |
| 32594120 | Until further details upon this interaction become available, we recommend physicians to be cautious with the prescription of P-gp inhibitors in patients receiving remdesivir therapy. | 2020-06-29 |
| 32594142 | Pediatric trials should focus on characterizing a treatment’s pharmacokinetics, optimal dose and safety, across the age spectrum. […] These trials should use an adaptive design to efficiently add or remove arms in what will be a rapidly evolving treatment landscape, and should involve a large number of sites across the globe in a collaborative effort to facilitate efficient implementation. […] All stakeholders must commit to equitable access to any effective, safe treatment for children everywhere. | 2020-06-29 |
| 32594164 | We collected data on baseline clinical characteristics, laboratory values, HIV infection status, COVID-19 treatment, and outcomes from this group and matched comparators (one PWH to up to five patients by age, sex, race/ethnicity and calendar week of infection). […] PWH hospitalized with COVID-19 had high proportions of HIV virologic control on antiretroviral therapy. | 2020-06-29 |
| 32594204 | Describe the scientific rationale related to the use of an antifibrotic therapy with pirfenidone, as monotherapy and/or in combination with anti-inflammatory drugs to manage and control complications of SARS-CoV-2 infection. […] The same approach can also be effective as postinfection therapy in patients with residual pulmonary fibrotic damage. […] Management of inflammation and fibrotic status with a combination therapy of pirfenidone and IL-6 or IL-1 inhibitors could represent a pharmacological synergy with added value. […] In this article, we consider the role of antifibrotic therapy with pirfenidone in patients with SARS-CoV-2 infection on going or in the stage of postinfection with pulmonary fibrotic consequences. | 2020-06-29 |
| 32594268 | We then summarize other challenging issues that may happen in PWE, who have COVID-19 and are receiving treatment. | 2020-06-29 |
| 32594281 | The outbreak of the coronavirus disease 2019 (COVID-19) has led to interruption or delay in treatment of breast cancer patient. […] This commentary aims to standardize the management procedures and ensure complete or relatively complete treatment for breast cancer patients during the outbreak of COVID-19. […] Provide detailed online diagnosis, online treatment recommendations, and face-to-face consultation suggestions. | 2020-06-29 |
| 32594284 | In oncofertility, patients should receive their fertility preservation treatments urgently even in limited resource settings before initiation of anticancer therapy. | 2020-06-29 |
| 32594470 | In spite of that we see almost two-thirds of the infected are still alive with a majority recovering fully after receiving treatment at the nursing home. | 2020-06-29 |
| 32594527 | Online therapy and supervision, a rapidly rising practice in couple and family therapy, has been the subject of a growing body of literature. […] From its early days, family therapy training has included live supervision, which has typically been conducted by a supervisor and a team of trainees situated on the other side of a one-way mirror. […] With the outbreak of the COVID-19 global pandemic, we-the staff of supervisors at the Barcai Institute in Tel Aviv, Israel-were compelled to find solutions to continue meeting with clients and to provide supervision for family therapy trainees. | 2020-06-29 |
| 32594562 | There is currently no known effective treatment for COVID-19. […] We have grouped these trials into four categories: prophylaxis; treatment of outpatients with mild COVID-19; treatment of hospitalised patients with moderate COVID-19; and treatment of hospitalised patients with moderate or severe disease. | 2020-06-29 |
| 32594627 | Participants with complaints were asked what they did for treatment. | 2020-06-29 |
| 32594756 | The impact of COVID-19 has challenged the long accepted ‘norm’ in delivery of psychological therapy. […] Further research is needed to better understand what might be lost and what gained in comparison to face-to-face therapy, and for which client groups and settings it might be most effective. | 2020-06-30 |
| 32594778 | PubMed/MEDLINETM databases were accessed between May 9th-June 9th, 2020, to review the latest perspectives on the treatment and pathogenesis of CRS. | 2020-06-30 |
| 32594821 | This review aims to answer the question, are biological therapies warranted in the treatment of psoriasis during the COVID-19 outbreak, or should they be discontinued? | 2020-06-30 |
| 32595136 | The COVID-19 pandemic has developed as a consequence of sheer prevention failures, leading in many countries to a sizeable number of deaths and over-saturation of intensive care units. | 2020-06-30 |
| 32595349 | In this review, we present the current scenario and status of epidemiology, diagnosis, treatment, vaccine development for COVID-19, and its impact on the socio-economic structure. | 2020-06-30 |
| 32595350 | Researchers are putting their very high efforts to develop suitable vaccines and therapeutics/drugs to combat COVID-19. | 2020-06-30 |
| 32595352 | All these data should be considered towards development of vaccine and antiviral treatment strategies as well as tracing diversity of virus in all over the world. | 2020-06-30 |
| 32595359 | Despite the highest scientific efforts and investments, a reliable and certified medication has yet to be developed regarding to immune or cure this virus. […] It also shows the importance of antiviral plants substances, particularly in the development of a broad spectrum medication for coronaviruses including SARS-CoV-2 responsible for COVID-19. | 2020-06-30 |
| 32595362 | Discovery of novel and broad-acting immunomodulators is of critical importance for the prevention and treatment of disorders occurring due to overexuberant immune responseincluding SARS-CoV-2 triggered cytokine storm leading to lung pathology and mortality during the ongoing viral pandemic. […] Owing to that, MSCs have been heavily investigated in clinic for the treatment of autoimmune and inflammatory diseases along with transplant rejection. […] In this review, we present the outcomes of preclinical and clinical studies utilizing MSC EVs as therapeutic agents for the treatment of a wide variety of immunological disorders. | 2020-06-30 |
| 32595613 | Currently, no registered antivirals have been approved for clinical therapy. […] Currently, remdesivir is under phase 3 clinical development for disease COVID-19 treatment. […] These data extend the remdesivir antiviral activity to enteroviruses and indicate that remdesivir is a promising antiviral treatment for EV71 and other enterovirus infections. | 2020-06-30 |
| 32595653 | In conclusion, our hypothesis proposes that nicotine could constitute a novel potential CRS therapy in severe SARS-CoV-2 patients. | 2020-06-30 |
| 32595947 | In this review, we have provided a picture of SARS-CoV-2 epidemiological characteristics, the clinical symptoms experienced by patients of varying age groups, the molecular virology of SARS-CoV-2, and the treatment regimens currently employed for fighting SARS-CoV-2 infection as well as their outcomes. | 2020-06-30 |
| 32595974 | The COVID-19 pandemic has brought about an urgent need for effective treatment, while conserving vital resources such as intensive care unit beds and ventilators. | 2020-06-30 |
| 32596068 | As the coronavirus 2019 (COVID-19) began spreading globally with no clear treatment in sight, prevention became a major part of controlling the disease and its effects. | 2020-06-30 |
| 32596078 | Although multiple drugs show promise in the treatment of COVID-19 via either inhibiting viral replication or preventing fusion of the virus to the ACE2 receptors, further investigation is still warranted and necessary before the admission of any type of pharmaceutical agent. […] Furthermore, several supplements have also been documented in being utilized as treatment of COVID-19. […] This review explores various drugs and their mechanism of action which are either currently being used in clinical trials or may be used in the future for the treatment of COVID-19. | 2020-06-30 |
| 32596085 | This case report provides anecdotal evidence for the effectiveness of the hydroxychloroquine and azithromycin combination currently being used across the nation to manage COVID-19, pending development of a definitive vaccine or antiviral treatment. | 2020-06-30 |
| 32596489 | Primary treatment entails radiotherapy ± chemotherapy depending on disease stage at presentation. […] These include patient selection and timing of treatment, while preventing disease transmission to heath care providers. | 2020-06-30 |
| 32596884 | In a field that strives to care for patients and families together, what can palliative care clinicians do when patients’ families are physically absent? […] Recently, I saw this in the case of a patient our palliative care team was consulted to see. | 2020-06-30 |
| 32596900 | Patients whose freedom and self-determination have been temporarily overruled as they receive involuntary psychiatric treatment deserve a setting that maintains their health and safety. […] While tele-mental health has been rapidly expanded to provide new ways to access psychiatric treatment, some patients may have limitations in technological literacy or access to devices. | 2020-06-30 |
| 32596910 | Madeleine, who was twenty-four years old, was dying of end-stage acute myeloid leukemia and was intubated in one of our intensive care units. […] Her intensivist had requested a clinical ethics consultation for potentially inappropriate medical treatment-in my world of clinical ethics consultation, routine stuff. | 2020-06-30 |
| 32596914 | However, neither employment-based health care nor a competitive health care market can adequately provide treatment during a global pandemic. | 2020-06-30 |
| 32596965 | However, at the end of the pandemic emergency, many benign and reconstructive cases will return to our attention and their surgical treatment will be necessary as soon as possible. | 2020-06-30 |
| 32597045 | Prescriptions of antihypertensive medication during the year before the outbreak were extracted from the National Health Insurance Service registry. […] Medications were categorized by types and stratified by the medication possession ratios (MPRs) of antihypertensive medications after controlling for the potential confounders. | 2020-06-30 |
| 32597046 | Currently there is no effective antiviral treatment for COVID-19. | 2020-06-30 |
| 32597047 | The epidemiological, laboratory, radiological, and treatment features of the pediatric patients who were positive for SARS-CoV-2 based on the reverse-transcription polymerase chain reaction (RT-PCR) test, were investigated retrospectively. | 2020-06-30 |
| 32597076 | So far, National Health Commission of the People’s Republic of China has issued seven trial versions of the “Guidelines for the Diagnosis and Treatment of COVID-19”. […] This paper reports a computer-aided intelligent analysis method based on machine learning, which can automatically analyze the similarities and differences of different treatment plans, present the focus of the new version to doctors, reduce the difficulty in interpreting the “diagnosis and treatment plan” for the professional, and help the general public better understand the professional knowledge of medicine. […] It enables the computer interpretation of “diagnosis and treatment plan” automatically and intelligently. | 2020-06-30 |
| 32597389 | We present two COVID-19 treatment center designs that leverage lessons learned from previous outbreaks of communicable infectious diseases and provide potential solutions when caseload exceeds existing capacity, with and without access to SARS-CoV-2 testing. | 2020-06-30 |
| 32597466 | In this small uncontrolled cohort of patients with moderate-severe COVID-19, treatment with baricitinib plus hydroxychloroquine was associated with recovery in 11 of 15 patients. […] Baricitinib for the treatment of COVID-19 should be further investigated in randomized controlled clinical trials. | 2020-06-30 |
| 32597503 | Our results indicate that melatonin could be a potential auxiliary therapy to treat immune dysfunction and microbial infections, including virus, under chronic disease conditions by restoring neutrophil functions. | 2020-06-30 |
| 32597627 | Currently, no adequate curative therapy for Coronavirus Disease 2019 (COVID-19) disease exists. | 2020-06-30 |
| 32597995 | To support frontline health care professionals caring for older adults, the current article provides guidance on strategies to optimize medication management within nursing homes and long-term care facilities. […] Food and Drug Administration emergency use authorization for treatment of COVID-19: hydroxychloroquine and remdesivir. | 2020-06-30 |
| 32598204 | Background: There is concern about susceptibility of psoriatic patients on biologics to coronavirus disease 2019 (COVID-19) and its clinical course.Purpose: The aims of present review were to determine whether the biologic treatment of psoriasis increases the risk of SARS-CoV-2 infection and if biologics affect the clinical course of COVID-19 in these patients.Methods: We searched database of MEDLINE (PubMed) for key term of psoriasis biologic and COVID-19 until June 9, 2020 and all published 14 papers and an experience from Iran (10509 cases) related to the psoriatic patients on biologics and COVID-19 along with relevant papers were summarized. […] Reports indicated psoriatic patients on biologics were not more susceptible to COVID-19 and the severe clinical course of disease.Conclusion: While there is not definitive controlled trial data, the available evidence suggests that patients with psoriasis without COVID-19 can continue the biologic therapy for psoriasis. | 2020-06-30 |
| 32598835 | ART services must return to operation, since infertility is also a disease and treatment has to start. […] Change is mandatory, to set us back to successful ART treatment without compromising on quality, and to minimize the spread of COVID-19 among staff and patients; and for this we need to take measured and vigilant steps. | 2020-06-30 |
| 32598880 | This study mainly focused on the very serious COVID-19 epidemic situation at present and provided a new insight for the treatment and monitor of patients with COVID-19. | 2020-06-30 |
| 32598911 | People with cancer and their physicians must balance plausible fears of coronavirus disease 2019 and cancer treatment with the consequences of delaying cancer care. […] Women with a current or previous diagnosis of ovarian cancer completed an online survey focusing on treatment interruptions and quality of life. […] At the time of survey completion, 217 participants (43.3%) were in active treatment. […] Ten (26.3%) of the 38 participants scheduled for surgery experienced a delay, as did 18 (8.3%) of the 217 participants scheduled for nonsurgical cancer treatment. […] On univariate analysis, age less than 65 years, being scheduled for cancer treatment or cancer surgery, delay in oncology care, being self-described as immunocompromised, and use of telemedicine were all associated with higher levels of cancer worry. | 2020-06-30 |
| 32598953 | This article reviewed the clinical use, mechanism and efficacy of the clinically approved drugs recommended in the Diagnosis and Treatment Protocol for Novel Coronavirus Pneumonia (DTPNCP) released by National Health Commission of P.R.China, and the novel therapeutic agents now undergoing clinical trials approved by China National Medical Products Administration (NMPA) to evaluate experimental treatment for COVID-19. […] Reviewing the progress in drug development for the treatment against COVID-19 in China may provide insight into the epidemic control in other countries. | 2020-06-30 |
| 32599011 | We evaluated common surgical masks and N95 respirators with respect to the changes in their performance and integrity resulting from autoclave sterilization and a 70% ethanol treatment; these methods are frequently utilized for re-used filtering facepieces in hospitals. […] The initial collection efficiency and the filter breathability may be compromised by sterilization in an autoclave and ethanol treatment. […] The effect depends on a protective device, particle size, breathing flow rate, type of treatment and other factors. | 2020-06-30 |
| 32599178 | There are no data on how acute treatment of COVID-19 may affect the convalescent phase or long-term cardiac recovery and function. | 2020-06-30 |
| 32599245 | A better understanding of the immune response to SARS-CoV-2 will be important to develop therapeutics against COVID-19. | 2020-06-30 |
| 32599258 | Balancing management of the infection and treatment of underlying cardiovascular disease requires further study. | 2020-06-30 |
| 32599285 | There is currently no effective antiviral therapy or immune-based treatment for coronavirus disease (COVID-19). […] This paper discussed nocturnal oxygen therapy as a new option for people with COVID-19 under home quarantine. […] It suggested that nocturnal oxygen therapy in the early stages may be helpful in preventing disease progression by inhibiting the rapid replication of the virus and improving the body’s antiviral ability. | 2020-06-30 |
| 32599499 | Surgery is the preferred treatment modality for oral squamous cell carcinoma (OSCC). […] However, due to limited resources, re-assessment of treatment paradigms in the wake of the Coronavirus Disease 2019 (COVID-19) pandemic is urgently required. | 2020-06-30 |
| 32599633 | Specific medical or drug treatment was not necessary. | 2020-06-30 |
| 32599783 | Given that HIV also has a disproportionate impact on marginalized communities, COVID-19 is affecting people with HIV (PWH) in unique ways and will continue to have an impact on HIV research and treatment after the COVID-19 crisis passes. […] Using the biopsychosocial framework to contextualize the impact of COVID-19 on PWH, the purpose of this review article is to: (1) outline the similarities and differences between the COVID-19 and HIV pandemics; (2) describe the current and future impact of COVID-19 on PWH; and (3) outline a call to action for scientists and practitioners to respond to the impact of COVID-19 on HIV prevention and treatment. | 2020-07-01 |
| 32599813 | Finally, the treatment of CAPA is complicated by drug-drug interactions associated with broad spectrum azoles, renal tropism and damage caused by SARS-CoV-2, which may challenge the use of liposomal amphotericin B, as well as the emergence of azole-resistance. | 2020-07-01 |
| 32599963 | Famotidine, a class A G protein-coupled receptor antagonist used for the treatment of gastroesophageal reflux was recently identified in an in silico screening. […] Additionally, a recent retrospective clinical report showed that the treatment with famotidine provided a good outcome in patients infected with SARS-CoV2. […] However, weak binding affinity of famotidine to these proteases suggests that a successful famotidine therapy could likely be achieved only in combination with other antiviral drugs. | 2020-07-01 |
| 32599968 | The aim of this manuscript is to investigate skin diseases associated with COVID-19 under three main headings: Skin problems related to personal protective equipment and personal hygiene measures, skin findings observed in SARS-CoV-2 virus infection and finally skin findings due to COVID- 19 treatment agents. […] In addition skin lesions could occur due to COVID-19 treatment agents. | 2020-07-01 |
| 32600002 | Joint replacement surgery is a highly effective treatment option for patients with severe osteoarthritis (OA) of the hip and knee when other treatments have failed. […] Non-operative treatment modalities for OA include education, lifestyle modification and exercise, mass reduction, physiotherapy, orthoses, psychology, pharmaceuticals and injections. […] Multimodal therapy is required for patients with severe symptoms. | 2020-07-01 |
| 32600165 | All the patients did not receive thyroid hormone replacement therapy. | 2020-07-01 |
| 32600183 | Prioritizing trainee protection and education as well as high-quality treatment for patients, the authors discuss effective communication strategies, rapid telepsychiatry expansion into clinical practice, curricular adjustments, and the importance of well-being. | 2020-07-01 |
| 32600350 | After 12 days of treatment, he can walk normally and communicate with near fluent language. | 2020-07-01 |
| 32600363 | Participants are assigned to treatment groups by using a randomisation list (1:1, block size = 4) and consecutive enrolment. | 2020-07-01 |
| 32600505 | As the most accessible health care professionals, community and ambulatory care pharmacists are well positioned to respond to this public health crisis by testing eligible patients–recently allowed by federal regulation–counseling them on treatment options for symptomatic relief, reinforcing prevention measures, and managing drug shortages. […] Hospital pharmacists also play an important role by assisting prescribers in selecting the best treatment regimens for patients, evaluating and securing investigational agents, developing criteria for drug use, mitigating drug shortages, and preserving personal protective equipment. […] In addition, long-term care pharmacists are instrumental in optimizing medication management and developing policies to reduce the risk of COVID-19 transmission among vulnerable residents. | 2020-07-01 |
| 32600512 | CMS now requires plans to waive cost sharing for COVID-19-related immunizations, testing, and treatment and suspend utilization review requirements related to drug-supply limits unless these limits are related to patient safety. | 2020-07-01 |
| 32600823 | The only currently effective treatment for obesity is metabolic surgery, which confers prompt, lasting benefits. | 2020-07-01 |
| 32600945 | A total of 6% of patients stated that infertility treatment, including IVF, should not be offered during the COVID-19 pandemic. | 2020-07-01 |
| 32600991 | It is unclear whether previous treatment with angiotensin-converting enzyme inhibitors (ACEI) and angiotensin receptor blockers (ARB) affects the prognosis of COVID-19 patients. […] The aim of this study was to evaluate the clinical implications of previous treatment with ACEI/ARB on the prognosis of patients with COVID-19 infection. […] Of the total population, 447 979 inhabitants, 965 patients (0.22%) were diagnosed with COVID-19 infection, and 210 (21.8%) were under ACEI or ARB treatment at the time of diagnosis. […] Treatment with ACEI/ARB (combined and individually) had no effect on mortality (OR, 0.62; 95%CI, 0.17-2.26; P=.486), heart failure (OR, 1.37; 95%CI, 0.39-4.77; P=.622), hospitalization rate (OR, 0.85; 95%CI, 0.45-1.64; P=.638), ICU admission (OR, 0.87; 95%CI, 0.30-2.50; P=.798), or major acute cardiovascular events (OR, 1.06; 95%CI, 0.39-2.83; P=.915). […] Previous treatment with ACEI/ARB in patients with COVID-19 had no effect on mortality, heart failure, requirement for hospitalization, or ICU admission. | 2020-07-01 |
| 32601006 | The clinical therapy for severe 2019 coronavirus disease (i.e., COVID-19) sufferers is relatively challenging. […] Eventually, the endotracheal tube was feasibly removed after intubation for 18 days and subsequently replaced with noninvasive ventilation and a high-flow nasal cannula oxygen therapy. | 2020-07-01 |
| 32601019 | From practice of prophylactic measures to availability of personal protective equipment, from access to diagnostic tests to treatment resources, there are many facets and distinct disease processes of a virus that, among many things, serves to expose and highlight our global disparities. | 2020-07-01 |
| 32601623 | We discuss here the disruptions on research in cancer with its immediate and delayed consequences and offer some suggestions to modify our practices, strategies and rationalization to help succeed the cancer treatment and research after the crisis is over. | 2020-07-01 |
| 32601708 | The definition, prevention, and treatment of symptoms of CRS in critically ill patients with COVID-19 are important problems. | 2020-07-01 |
| 32601725 | The FAHZU, as the earliest designated hospital, accomplished the transformation from general hospital to infectious disease hospital under the guiding ideology of centralized patients, centralized experts, centralized resources, and centralized treatment with measures to transfer the Zhijiang campus hospitalized patients quickly, complete the space layout, create diagnosis and treatment space, streamline logistics, and transform logistics facilities within 48 h. […] Of the severe cases in Zhejiang province 95% underwent centralized treatment with the goal of zero deaths for severely ill patients, zero misdiagnoses for infected patients, and zero infections for medical staff, and this served as a reference for large medical institutions regarding how to manage such a public health emergency. […] The successful cases of FAHZU provided a valuable experience for large medical institutions on how to address public health emergencies and how to carry out diagnosis and treatment and streamline the layout and related facilities in emergency reconstruction. | 2020-07-01 |
| 32601848 | The care of each patient must of course be determined on an individual basis; however, the experience of the authors is that a short delay in scheduled distractions and clinic visits will not adversely impact patient treatment. | 2020-07-01 |
| 32601854 | Dexamethasone is commonly used for antiemetic prophylaxis with systemic therapy for cancer. […] Our purpose was to minimize dexamethasone exposure during antiemetic prophylaxis for systemic therapy for solid tumors during the COVID-19 pandemic, while maintaining control of nausea and emesis. | 2020-07-01 |
| 32601923 | Deep knowledge about the interaction between coronaviruses and the host factors could be useful to provide a better support for the disease sufferers and be advantageous for managing and treatment of the lung infection caused by the virus. | 2020-07-01 |
| 32602006 | These patients received less frequently pharmacological treatment with hydroxychloroquine or antivirals and had a greater number of complications such as sepsis (11.9% vs 26.4% vs 40.8%, p < 0.001) and respiratory failure (35.4% vs 72.2% vs 62.0%, p < 0.001) as well as a higher in-hospital mortality rate (eGFR > 60 vs eGFR 30-60 vs and eGFR < 30, 18.4% vs 56.5% vs 65.5%, p < 0.001). | 2020-07-01 |
| 32602202 | Epidemiological, clinical, and laboratory characteristics and treatment data were collected. | 2020-07-01 |
| 32602262 | Our patient selection and treatment approach should be considered for investigation in a clinical trial to determine the safety and efficacy of anakinra in patients with COVID-19 and features of CSS. | 2020-07-01 |
| 32602272 | The use of medication did not affect the SCO, but the renin-angiotensin system inhibitors showed protective effects against acute cardiac injury (OR, 0.048; P=0.045). | 2020-07-01 |
| 32602404 | We expanded intensive care units into our medical surgical units while turning conference rooms into medical surgical patient care areas. | 2020-07-01 |
| 32602604 | The data on demographics, comorbidities, clinical symptoms, laboratory examinations on admission, complications, treatment, and outcome were collected. | 2020-07-01 |
| 32602627 | We also provide our perspectives on COVID-19 treatment and prevention. | 2020-07-01 |
| 32602676 | Epidemiological, demographic, clinical, laboratory, radiological, and treatment data were collected and analyzed. | 2020-07-01 |
| 32602678 | Demographical, clinical, laboratory, and radiological characteristics and treatment and outcomes data were obtained with data collection forms and history given by 26 COVID-19 patients. | 2020-07-01 |
| 32602680 | Cancer patients are considered to be at higher risk of developing life-threatening complications from COVID-19 and at the same time treatment delays can lead to poorer oncological outcomes. […] Appropriate planning is therefore important to continue with cancer treatment services and simultaneously avoiding the risk of infection to the patients and healthcare staff and not allowing community transmission of viral infection. […] We modified our practice measures in cancer patients receiving systemic therapy. | 2020-07-01 |
| 32602763 | Teledermatology was efficient in triaging and treatment, hence, decreasing risk of COVID-19 exposure for the physician, the patient and the paramedical personel in heavily populated third world countries. | 2020-07-01 |
| 32603180 | It has been observed that about 20 % of patients will require hospitalization, and some of them will need the support of invasive mechanical ventilation in intensive care units. | 2020-07-01 |
| 32603252 | Providers must carefully weigh risks and benefits of delivering immunosuppressive therapy during the pandemic. […] For breast cancer, a key difference is increased use of neoadjuvant systemic therapy due to deferral of many breast surgeries during the pandemic. […] In some cases, this necessitates increased use of genomic tumor profiling on core biopsy specimens to guide neoadjuvant therapy decisions. […] Breast cancer treatment during the pandemic requires multidisciplinary input and varies according to stage, tumor biology, comorbidities, age, patient preferences, and available hospital resources. […] These algorithms emphasize medical oncology treatment decisions and demonstrate how we have operationalized the general treatment recommendations during the pandemic proposed by national groups, such as the COVID-19 Pandemic Breast Cancer Consortium. […] Guidelines such as these will be important as we continue to balance treatment of breast cancer against risk of SARS-CoV-2 exposure and infection until approval of a vaccine. | 2020-07-01 |
| 32603486 | Introducing a treatment against COVID-19, either on an outpatient basis or during hospitalization for more severe cases, raises the question of potential drug-drug interactions. […] Here, we analyzed the potential or proven risk of the co-administration of drugs used for the most common chronic diseases and those currently offered as treatment or undergoing therapeutic trials for COVID-19. | 2020-07-01 |
| 32603505 | Therefore, there is an urgent need for devising more efficient preventive measures, to limit the spread of the infection until an effective treatment or vaccine is available. […] These findings suggest a possible risk of faecal-oral, foodborne and waterborne transmission of SARS-CoV-2 in developing countries that often use sewage-polluted waters in irrigation and have poor water treatment systems. | 2020-07-01 |
| 32603531 | In addition, CT findings were evaluated on admission and 14 days after initiation of treatment. […] The mean percentages of lung involvement were significantly reduced to 7.3% and 8% after 14 days of treatment with FBX and HCQ, respectively. […] This trial suggests that FBX is as an alternative treatment to HCQ for COVID-19 infection and may be considered in patients with a contraindication or precaution to HCQ. | 2020-07-01 |
| 32603572 | He was commenced on broad-spectrum antimicrobials and oxygen therapy. […] Patient 2 was transferred to another centre for ECMO therapy. | 2020-07-01 |
| 32603679 | In case of severe disease, treatment with a calcineurin inhibitor could be promising. […] In this article we explain the mechanisms of calcineurin inhibitor treatment for COVID-19, based on experiences seen in solid organ transplant recipients who suffered from COVID-19. | 2020-07-01 |
| 32603692 | Despite the knowledge of previous coronaviruses, such as those responsible for the SARS and MERS-CoV epidemic, there is no drug or prophylaxis treatment to this day. | 2020-07-01 |
| 32603802 | Corticosteroids are commonly used as adjuvant therapy for acute respiratory distress syndrome by many clinicians because of their perceived anti-inflammatory effects. […] However, for patients with severe viral pneumonia, the corticosteroid treatment is highly controversial. […] We comprehensively searched all manuscripts on corticosteroid therapy for influenza, severe acute respiratory syndrome (SARS), Middle East respiratory syndrome (MERS) and SARS coronavirus 2 (SARS-CoV-2) viral pneumonia from the PubMed, EMBASE, Web of Science and Cochrane Library databases. […] We systematically summarized the effects of corticosteroid therapy for pandemic viral pneumonia and the potential mechanism of action for corticosteroids in coronavirus disease 2019 (COVID-19). […] Observational studies showed that corticosteroid treatment was associated with increased mortality and nosocomial infections for influenza and delayed virus clearance for SARS-CoV and MERS-CoV. […] Limited data on corticosteroid therapy for COVID-19 were reported. […] Although clinical observational studies reported the improvement in symptoms and oxygenation for individuals with severe COVID-19 who received corticosteroid therapy, case fatality rate in the corticosteroid group was significantly higher than that in the non-corticosteroid group (69/443, 15.6% versus 56/1310, 4.3%). […] Compared individuals with non-severe disease, those with severe disease were more likely to receive corticosteroid therapy (201/382, 52.6% versus 201/1310, 15.3%). […] Although there is no evidence that corticosteroid therapy reduces mortality in people with COVID-19, some improvements in clinical symptoms and oxygenation were reported in some clinical observational studies. […] Sufficiently powered randomized controlled trials with rigorous inclusion/exclusion criteria and standardized dose and duration of corticosteroids are needed to verify the effectiveness and safety of corticosteroid therapy. | 2020-07-01 |
| 32603887 | The identified articles, journal papers and preprints, mostly covered the epidemiology of COVID-19 (35.7 %), clinical aspects of infection (21.0 %), preventative measures (12.8 %), treatment options (12.5 %), diagnostics (12.2 %), mathematical modeling of disease transmission and mitigation (9.6 %), and molecular biology and pathogenesis of SARS-CoV-2 (8.7 %). | 2020-07-01 |
| 32603930 | Nine of the cases presented with psychotic symptoms at least two weeks after the first somatic manifestations attributed to COVID-19 and receiving pharmacological treatment. | 2020-07-01 |
| 32604085 | Computed tomography (CT) of the chest can verify infection in patients with clinical symptoms and a negative test result, accelerating treatment and actions to prevent further contagion. | 2020-07-01 |
| 32604133 | Arbitrary laws and counterproductive policies previously subject to only incremental reform have given way to sweeping changes: people convicted of nonviolent drug crimes have been released from jails and prisons, the enforcement of drug laws has been cast aside as a priority, and the regulations surrounding addiction treatment medications and treating patients with OUD have been greatly loosened. | 2020-07-01 |
| 32604223 | Due to our insufficient understanding of its pathophysiology and lack of effective treatment, the morbidity and mortality of severe COVID-19 patients are high. […] Given that B-1a cells protect against ARDS via immunoglobulin production and the anti-COVID-19 effects of convalescent plasma treatment, we recommend that studies be conducted to further examine the role of B-1a cells in the pathogenesis of COVID-19 and explore their therapeutic potential to treat COVID-19 patients. | 2020-07-01 |
| 32604407 | We believe that a personalized, immunophenotype-driven approach to immunomodulation that may include anti-cytokine therapy in carefully selected patients and immunostimulatory therapies in others is the shortest path to success in the study and treatment of patients with critical illness due to COVID-19. | 2020-07-01 |
| 32604415 | During this period there were approximately 950 patients hospitalized for treatment of COVID-19. | 2020-07-01 |
| 32604478 | The ongoing COVID-19 pandemic is having a significant impact on people with palliative care needs. | 2020-07-01 |
| 32604730 | Under the current circumstances where reliable antiviral therapeutics or vaccination tools are lacking, several trials are underway to examine viral agents. | 2020-07-02 |
| 32604775 | Treatment approaches are the most frequent purpose of the registered studies. | 2020-07-02 |
| 32604895 | Eosinophilic gastrointestinal diseases (EGIDs) are chronic gastrointestinal conditions requiring corticosteroid and immunosuppressive therapy for disease control. […] All of them were adherent to therapy and preventive measures adoption. […] Most patients were worried because of COVID-19 and social preventing measures but did not consider themselves at major risk or susceptible to COVID-19 or other infections due to their chronic condition or therapy. | 2020-07-02 |
| 32604919 | This would facilitate an appropriate treatment, a prompt isolation and consequently deceleration of the pandemic. | 2020-07-02 |
| 32605192 | Consequently, the scientific community is working hard to gain useful information about the history of this virus, its transmission, diagnosis, clinical features, radiological findings, research and development of candidate therapeutics as well as vaccines. | 2020-07-02 |
| 32605194 | Similarly, vaccines and therapeutics against COVID-19 are currently in the pipeline for clinical trials. […] In this review, we discuss the noteworthy advancements, focusing on the etiological viral agent, comparative genomic analysis, population susceptibility, disease epidemiology and diagnosis, animal reservoirs, laboratory animal models, disease transmission, therapeutics, vaccine challenges, and disease mitigation measures. | 2020-07-02 |
| 32605278 | Currently, there is no vaccine and no approved therapy. […] Thus, efforts should be made to provide adjuvant organ protection therapy. | 2020-07-02 |
| 32605363 | The SARS-CoV-2 pandemic has created an unprecedented need for rapid diagnostic testing to enable the efficient treatment and mitigation of COVID-19. | 2020-07-02 |
| 32605549 | Scientific studies to date have focused primarily on describing the clinical course of patients, identifying treatment options and developing vaccines. | 2020-07-02 |
| 32605661 | We illustrated that meta uncovered rich genetic information in the clinical samples besides SARS-CoV-2, providing references for clinical diagnostics and therapeutics. | 2020-07-02 |
| 32605683 | The most common pharmacological treatment regimens administered were zinc, hydroxychloroquine plus azithromycin and convalescent plasma. […] These findings may provide insight into disease severity and treatment options in the rural setting with limited resources to participate in clinical trials and encourage larger comparative studies evaluating treatment efficacy. | 2020-07-02 |
| 32605700 | However, for patients with asthma and who have recovered from COVID-19 infection, the timing of resumption of asthma therapy is equally uncertain. […] We highlighted the potential utility of using COVID-19 RNA detection as well as immunoglobulin G antibody testing to help guide the timing of resumption of asthma therapy. | 2020-07-02 |
| 32606050 | Drug repurposing, a strategy that uses existing drugs, offers potential prevention and treatment options for COVID-19. […] We discuss one treatment strategy that combines anti-inflammatory (melatonin) and antiviral (toremifene) agents for patients infected with SARS-CoV-2 from network medicine-based findings. […] We also describe the pathobiology and immunologic characteristics of COVID-19 and highlight the rationale of combination drug treatment to rescue the pulmonary and cardiovascular conditions resulting from COVID-19. […] A preliminary analysis reveals a high potential for the synergistic effects of melatonin and toremifene to reduce viral infection and replication, and the aberrant host inflammatory responses, offering strong biologic plausibility as an effective therapy for COVID-19. | 2020-07-02 |
| 32606103 | At sites with suspended trials (n=51), endovascular treatment without enrollment occurred at 31 (61%) sites for stroke and 23 (45%) sites for aneurysms. | 2020-07-02 |
| 32606248 | The flat-targeting modality demonstrated here has the potential to expand the druggable target range of small-molecule therapeutics. | 2020-07-02 |
| 32606886 | Understanding the nature of pathogen-host interaction in COVID-19 symptomatology together with the role of hypercytokinemia in disease severity may permit developing new avenues of approach for prevention and treatment and can delineate public health measures to control the spread of the disease. | 2020-07-02 |
| 32607332 | The diagnostic criteria, clinical classification, and discharge standard related to COVID-19 were in line with the Diagnosis and Treatment Protocol for Novel Coronavirus Pneumonia (Trial Version 7) released by National Health Commission and National Administration of Traditional Chinese Medicine. […] All the patients received antiviral drugs, 38 (79.2%) accepted traditional Chinese medicine, and 2 (4.2%) received treatment of human umbilical-cord mesenchymal stem cells. | 2020-07-02 |
| 32607346 | Body temperature in all 3 patients returned to normal after several days without treatment, and fever recurrence was not observed. | 2020-07-02 |
| 32607373 | The first case of #COVID19 in Foshan provides a reference for the treatment of severe #SARSCoV2 pneumonia https://bit.ly/3eD81qj. | 2020-07-02 |
| 32607393 | Comprehension of the disease molecular pathogenesis could provide useful tools for COVID-19 patients in surveillance, prognosis, treatment, vaccine development and therapeutic targeting. […] Plasmin is another possible candidate both in diagnosis and treatment areas. | 2020-07-02 |
| 32607394 | Since our hospital had become a leading center for the treatment of COVID-19 patients, and the number of referred trauma patients, elective, and trauma operations, along with educational activities, was reduced. | 2020-07-02 |
| 32607398 | Leucomethylene Blue (reduced form of MB, colorless) may be applied for the treatment of COVID-19 according to the scientific evidences. | 2020-07-02 |
| 32607400 | According to the results, two patients underwent surgical treatment, and one patient had negative reverse transcription-CRP; however, all of them underwent medical treatment for COVID-19 infection. | 2020-07-02 |
| 32607467 | Future treatment options should focus on blocking the thrombogenic and inflammatory properties of angiotensin II in COVID-19 patients. | 2020-07-02 |
| 32607499 | To date, there is no specific vaccine or treatment proven effective against this viral disease. | 2020-07-02 |
| 32607505 | It is hoped that these efforts will results in a successful treatment to COVID-19, especially in a timely fashion before the second pandemic expected in fall. | 2020-07-02 |
| 32607555 | Remdesivir is a prodrug of the nucleoside analogue GS-441524 and is under evaluation for treatment of SARS-CoV-2-infected patients. | 2020-07-02 |
| 32607704 | Diagnostic catheterisations, coronary and structural interventions, as well as the incidence and delay to reperfusion therapy of myocardial infarction (STEMI), were recorded. […] There was a significant decrease in the number of diagnostic procedures (-65.2%), coronary interventions (-59.4%), structural therapeutics (-86.1%) and STEMI care (-51.2%). […] Healthcare providers should encourage patients with suspected symptoms of STEMI to call for emergency care to ensure rapid diagnosis and timely reperfusion treatment. | 2020-07-02 |
| 32607830 | A comprehensive summary of the preparation of the facilities as well as pre- treatment, treatment and posttreatment protocols are described and arising problems are being discussed. […] The importance of rigorous hygiene and treatment protocols as well as a sufficient supply of PPE for dental offices and hospitals is highlighted. | 2020-07-02 |
| 32607860 | In rectal cancer, time to surgery over 7 to 8 weeks following neoadjuvant therapy is associated with decreased survival. […] Early resection of gastrointestinal malignancies provides the best chance for curative therapy. | 2020-07-02 |
| 32608159 | C5 blockade reduces inflammatory cytokines and their manifestations in animal studies, and has shown benefits in patients with aHUS, prompting investigation of this approach in the treatment of COVID-19. | 2020-07-02 |
| 32608926 | We describe the presentation of the COVID-19 patients on the emergency department, the development of the disease, and the treatment of these patients on the ICU. | 2020-07-02 |
| 32609083 | Because of in vitro studies, hydroxychloroquine has been evaluated as a preexposure or postexposure prophylaxis for coronavirus disease (COVID-19) and as a possible COVID-19 curative treatment. […] We report a case of COVID-19 in a patient with sarcoidosis who was receiving long-term hydroxychloroquine treatment and contracted COVID-19 despite adequate plasma concentrations. | 2020-07-02 |
| 32609142 | to describe the most frequent signs and symptoms of infection by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). this is a narrative literature review carried out in April 2020; the search was performed on electronic databases and complemented with a manual review of the references of the selected papers and Brazilian Ministry of Health publications. the spectrum of clinical disease was wide; fever, coughing and dyspnea were the most frequent signs/symptoms, however, they may not be present, thus hindering case definition; gastrointestinal symptoms and loss of taste or smell have been reported among mild cases; dyspnea was frequent among severe and fatal cases. considering the scarcity of diagnostic tests and the diversity of symptoms, health services should use a sensitive case definition, in order to adopt appropriate surveillance, prevention and treatment actions. | 2020-07-02 |
| 32609145 | The present study sought to evaluate the impact of quarantine resulting from the coronavirus disease 2019 (COVID-19) pandemic on dental appointments and patients’ positions and concerns regarding their ongoing dental treatment. […] Patients from private dental clinics answered an online questionnaire anonymously regarding their treatment, availability and willingness to attend dental appointments, and concerns about contamination. […] Most patients reported they were receiving dental treatment (orthodontics) and would attend to a dental appointment; meanwhile, those patients not receiving treatment would not attend or would visit only in the case of an emergency. […] Males reported to be calmer than females, who were more anxious and afraid; as such, males reported more willing to go a dental appointment while, in general, females were not worried about how quarantine could affect dental treatment. […] Patients actively undergoing treatment and orthodontic patients were more concerned about a delay in treatment. […] Overall, patients undergoing dental treatment and orthodontics were more willing to attend an appointment and were more concerned about an increase in treatment duration. | 2020-07-02 |
| 32609168 | The main questions by participants related to risk factors, transmission, immunity to the novel coronavirus, care related to prevention, symptoms, and treatment; and COVID-19 and influenza vaccine. | 2020-07-02 |
| 32609235 | Due to the lack of a vaccine or specific treatment, there are at least three types of interventions used in the first wave of this pandemic: increased alertness and hygiene (e.g. […] The search for a miracle drug is dangerous because it is based on the mistaken belief that any treatment option is better than “nothing”. | 2020-07-02 |
| 32609284 | Data were analyzed and synthesized in the form of a narrative. the final sample was composed of 24 records, the content of which was synthesized in these conceptual categories: clinical manifestations, diagnosis, treatment, working pregnant women, vaccine development, complications, prenatal care, vertical transmission, and placental transmissibility. | 2020-07-02 |
| 32609290 | We focus on how to 1) reduce COVID-19 infection risk, such as social distancing, telemedicine, and wider interval between laboratory testing/imaging; 2) manage relapses, such as avoiding treatment of mild relapse and using oral steroids; 3) manage disease-modifying therapies, such as preference for drugs associated with lower infection risk (interferons, glatiramer, teriflunomide, and natalizumab) and extended-interval dosing of natalizumab, when safe; 4) individualize the chosen MS induction-therapy (anti-CD20 monoclonal antibodies, alemtuzumab, and cladribine); 5) manage NMOSD preventive therapies, including initial therapy selection and current treatment maintenance; 6) manage MS/NMOSD patients infected with COVID-19. | 2020-07-02 |
| 32609336 | All 4 patients required intensive care unit admission for the treatment of COVID-19 pediatric multisystem inflammatory syndrome. | 2020-07-02 |
| 32609557 | However, thoracic cancer surgery should proceed as normal for all solid tumors, without restrictions based on disease stage, availability of non-surgical treatment options, or patient condition (unless there is a high likelihood of postoperative intensive care unit stay). | 2020-07-02 |
| 32609839 | This association may not imply a true or causal relationship, and smoking is not advocated as a prevention or treatment of COVID-19. […] Most importantly, to date, no study, including this one, supports the view that smoking acts as a treatment intervention or prophylaxis to reduce the impact or ameliorate the negative health impacts of COVID-19. | 2020-07-02 |
| 32610165 | Hydroxychloroquine (HCQ) has been promoted as a potential treatment of coronavirus disease 2019 (COVID-19), but there are safety concerns. […] The purpose of this study was to determine the effects of HCQ treatment on QT interval. […] The primary outcome was corrected QT (QTc) interval, by Bazett formula, during HCQ therapy. […] Median dosage of HCQ was 400 mg daily, and median (25th-75th percentile) duration of HCQ therapy was 1006 (471-2075) days. […] Mean on-treatment QTc was 430.9 ± 31.8 ms. […] In a subset of 591 patients who also had a pretreatment electrocardiogram, mean QTc increased from 424.4 ± 29.7 ms to 432.0 ± 32.3 ms (P <.0001 during hcq treatment. of these patients had either prolongation qtc>15% or on-treatment QTc >500 ms. […] QTc >470 ms during HCQ treatment was associated with a greater mortality risk (hazard ratio 1.78; 95% confidence interval 1.16-2.71; P = .008) in univariable but not in multivariable analysis. </.0001> | 2020-07-02 |
| 32610262 | Interest in corticosteroid therapy in COVID-19 has been rekindled after the results from Randomized Evaluation of COVid-19 thERapY (RECOVERY) Trial. […] However, the World health Organization has not recommended corticosteroid in the treatment of COVID-19. […] RECOVERY trial is the only randomized controlled trial that has shown a significant reduction of death by 35% in ventilated patients and by 20% amongst patients on supplemental oxygen therapy with the dexamethasone, although no benefit was observed in mild cases. | 2020-07-02 |
| 32610401 | Methods: A retrospectively analysis was conducted to explore the clinical data of COVID-19 patients who received tracheotomy in February to March 2020, and descriptive statistics were used to analyze the indication of tracheotomy, particularity of intraoperative treatment and protective measures. | 2020-07-02 |
| 32610445 | Our study provides insight into the role of the Mpro structural flexibility during interactions with the possible inhibitors and sheds light on the structure-based design of anti-coronavirus disease 2019 (COVID-19) therapeutics targeting SARS-CoV-2. | 2020-07-03 |
| 32610730 | We describe the positive opportunities that the COVID-19 crisis has opened to reduce the sources of waste for our health systems: failures of care delivery, failures of care coordination, overtreatment or low-value care, administrative complexity, pricing failures and fraud and abuse. | 2020-07-03 |
| 32610859 | The aim of this report is to describe the clinical profiles of these Covid-19 infected patients admitted in Sawai Mansingh Hospital(S.M.S), Jaipur ranging from their age, sex, travel history, clinical symptoms, laboratory evaluation, radiological characteristics, treatment provided along with common side effects and the final outcome. […] Epidemiological, clinical, laboratory, and radiological characteristics and treatment and outcomes data were obtained with data collection forms from electronic medical records and history given by 21 Covid-19 infected patients admitted in S.M.S., Jaipur. […] These patients had deranged liver functions and had elevated pro-calcitonin levels, serum ferritin levels and LDH levels. 1 out of the these 4 cases went into ARDS during the course of treatment. 10 patients yielded negative results for Covid-19. […] The mean duration from admission to getting 1st Covid-19 sample negative was 8.3 days. 18 patients (85.71%) are still under treatment. | 2020-07-03 |
| 32610873 | The present study was undertaken to investigate epidemiological distribution, clinical manifestation, co morbid status, treatment strategy and case fatality index of emerging COVID-19 infection at SMS Medical College Hospital, Jaipur, Rajasthan. […] It also evaluated efficacy of hydroxychloroquine (HCQ) in treatment of patients and risk of serious adverse outcomes in patients with COVID-19 in relation to their co morbid status. […] The indoor admitted patient’s information inclusive of demographic profile (age, sex, nationality, residence), date of confirmation for positive COVID-19 case, travel/ exposure history, date of recovery/ death, clinical features, co morbidities and treatment plan was recorded. […] 60.27% of patient population with underlying co morbid conditions were more prone to develop symptomatology complex as compared to that observed in patients with no co morbidity (18.42%). 116 patients had recovered with effective treatment till the date of data analysis. […] Asymptomatic patients (cases) treated with HCQ recovered early (average recovery time =5.4 days) compared to asymptomatic patients who did not receive any treatment (control group) and had longer recovery time (average recovery time =7.6 days). […] Average recovery time from COVID-19 was 8 days with effective treatment. […] Treatment with HCQ had early recovery without effectively influencing the overall mortality. | 2020-07-03 |
| 32610879 | These drugs are already in widespread use for the treatment of COVID-19 in India, mainly because they are cheap and easily available, and because of the absence of any readily available alternative therapy. | 2020-07-03 |
| 32611087 | There is an urgent necessity of effective medication against severe acute respiratory syndrome coronavirus 2 (SARS CoV-2), which is producing the COVID-19 pandemic across the world. | 2020-07-03 |
| 32611470 | Youth mental health is a rapidly developing field with a focus on prevention, early identification, treatment innovation and service development. | 2020-07-03 |
| 32611473 | The COVID-19 pandemic has posed many challenges in maintaining standards of care and treatment for patients while managing the increased anxieties of patients, carers and the public in general. | 2020-07-03 |
| 32611509 | Video visits were conducted for eating disorders (39%), contraception/menstrual disorders (22%), gender-affirming care (17%), general adolescent medicine (15%), HIV treatment (6%), and substance abuse (1%). | 2020-07-03 |
| 32611701 | These findings suggest that a potential for fomite transmission may persist for hours to days in indoor environments and have implications for assessment of the risk posed by surface contamination in indoor environments.IMPORTANCE Mitigating the transmission of SARS-CoV-2 in clinical settings and public spaces is critically important to reduce the number of COVID-19 cases while effective vaccines and therapeutics are under development. | 2020-07-03 |
| 32611911 | This article was aimed to review the evidence on clinical management and to deal with the identification of high-risk groups, warning signs, appropriate investigations, proper sample collection for confirmation, general and specific treatment measures, strategies as well as infection control in the healthcare settings. | 2020-07-03 |
| 32611912 | Retinal screening is unnecessary for coronavirus patients taking chloroquine or hydroxychloroquine as the probability of toxic damage to the retina is less due to short-duration of drug therapy. | 2020-07-03 |
| 32612371 | Since no successful treatment and vaccine have been reported, efforts to enhance the knowledge, attitudes, and practice of the public, especially the high-risk groups, are critical to manage COVID-19 pandemic. | 2020-07-03 |
| 32612430 | Herein, we aimed to investigate unclear issues related to transmission and pathogenesis of disease as well as accuracy of diagnostic tests and treatment modalities. | 2020-07-03 |
| 32612432 | In this review, we aimed to present the current understanding of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection during pregnancy and neonatal periods considering diagnosis, treatment, prognosis, and prevention. […] There is much to be learnt about COVID-19 in pregnant women and in the neonates, especially concerning prognosis- and treatment-related issues. | 2020-07-03 |
| 32612465 | All individuals developed acute respiratory distress syndrome refractory to conventional medical therapy and subsequently died from their disease. | 2020-07-03 |
| 32612666 | We also review therapeutic considerations and strategies for treatment of COVID-19 in diabetic patients, and how the additional challenge of this co-morbidity requires attention to glucose homeostasis so as to achieve the best outcomes possible for patients. | 2020-07-03 |
| 32612712 | These disruptions will call on clinicians to have greater consideration for non-operative treatment options to help manage patient symptoms and provide therapeutic care in lieu of the traditional surgical management course of action. […] The general guidance provided by these reports was to have an increased consideration for non-operative treatment options whenever possible and safe. […] It is imperative that clinicians and patients consider non-operative, conservative treatment options in order to manage conditions and symptoms until surgical management options become available again, and to manage the increased surgical waitlists caused by the elective surgery shutdowns. | 2020-07-03 |
| 32612804 | As yet, no agents have been approved for the treatment of COVID-19, although several experimental drugs are being used off licence. […] We reviewed the common agents being used across the world for the treatment of COVID-19 and investigated their drug interaction potential with psychotropic agents using several drug interaction databases and resources. […] Significant caution should be exercised if using any of the medications being trialled for the treatment of COVID-19 until robust clinical trial data are available. | 2020-07-03 |
| 32612971 | Objective: Report the epidemiological, clinical features, laboratory, radiological characteristics, and treatment of SARS-CoV-2 infections. | 2020-07-03 |
| 32613010 | Moreover, the reorganization of health services around the pandemic response further exacerbates the growing crisis around limited access, treatment compliance, acute medical needs, and mental health of patients in this specific subgroup. | 2020-07-03 |
| 32613089 | The biggest complication is pneumonia, which has a serious inflammatory component, with no standardized treatment. […] Low-dose radiation therapy (LD-RT) is non-invasive and has anti-inflammatory effects that can interfere with the inflammatory cascade, thus reducing the severity of associated cytokine release and might be useful in the treatment of respiratory complications caused by COVID-19. […] This multicentric prospective clinical trial seeks to evaluate the efficacy of bilateral lung LD-RT therapy as a treatment for interstitial pneumonia in patients with COVID-19 for improving respiratory function.This prospective study will have 2 phases: I) an exploratory phase enrolling 10 patients, which will assess the feasibility and efficacy of low-dose lung irradiation, evaluated according to an increase in the PaO2/FiO2 ratio of at least 20% at 48-72 h with respect to the pre-irradiation value. […] II) Non-randomized comparative phase in two groups: a control group, which will only receive pharmacological treatment, and an experimental arm with pharmacological treatment and LD-RT. | 2020-07-03 |
| 32613258 | Despite the challenge of a significant shift of medical resources during the SARS-CoV‑2 pandemic, medically urgently necessary ophthalmological treatments are continuously provided by maximum care clinics; however, based on currently available data, it cannot be ruled out whether treatment of emergency patients was delayed during the pandemic. | 2020-07-03 |
| 32613637 | On the whole, the favorable effects of naringenin lead to a conclusion that naringenin may be a promising treatment strategy against COVID-19. | 2020-07-03 |
| 32613660 | The patients with higher nutrition risk have worse outcome and require nutrition therapy. | 2020-07-03 |
| 32613929 | The second is to adapt and adopt current venous thromboembolism diagnostic and treatment guidelines, while relying on the limited available observational reporting of COVID-19 patients to create a comprehensive clinical guideline to treat COVID-19 patients. | 2020-07-03 |
| 32614392 | Antiviral therapy and corticosteroid treatment were not independent factors. | 2020-07-03 |
| 32614440 | In this paper, we report the lessons from the Fukushima disaster that can be applied to the COVID-19 pandemic and describe how the telephonic intervention facilitates easier access to psychological help for people with a broad range of psychological distress who are not able to visit treatment or care resources. | 2020-07-03 |
| 32614464 | We recorded their clinical manifestations, epidemiological history, laboratory examination, and treatment in detail. | 2020-07-03 |
| 32614740 | The review focuses on the life cycle, targets, and possible therapeutic strategies, which can lead to further research and development of COVID-19 therapy. | 2020-07-03 |
| 32614777 | Purpose was further classified into the following categories: news, general information, self-diagnosis, contact tracing, notices to contacts, notification of close cases, awareness, helplines, monitoring of clinical parameters, recording of symptoms and treatment, and messaging with health care professionals. | 2020-07-03 |
| 32614778 | Additional research is needed to identify trusted sources of information in Hispanic and non-Hispanic Black communities and create effective messaging to disseminate correct COVID-19 prevention and treatment information. | 2020-07-03 |
| 32614854 | Dynamic observations were performed in four patients after COVID-19 treatment. […] Among these four patients, one patient showed normal on the initial examination, and new lesions were observed after 3 days; 1 patient showed progression after 7 days of treatment, with expansion of the lesion area; and the other 2 patients showed improvement after 14 days of treatment, with reduction in the density and area of lesions and appearance of linear opacity. | 2020-07-03 |
| 32615046 | Immunosuppressive therapy should not be withheld, unless the patient develops SARS-CoV2 infection. | 2020-07-03 |
| 32615182 | Since Covid-19 infection and complications involve severe inflammation and oxidative stress in people with obesity and diabetes, we anticipated the inclusion of melatonin, as powerful antioxidant, within proposed treatment protocols. | 2020-07-03 |
| 32615317 | The current result provides an explanation of the pathophysiology for post-infectious sequelae and potential targets for treatment. | 2020-07-03 |
| 32615555 | Continuous renal replacement therapy was significantly more frequent in severe cases and in dead patients. | 2020-07-03 |
| 32615569 | Finally, we discuss the enormous potential of this technology in an era of increasing antibiotic resistance and high mortality associated with sepsis and consider the application of this as a possible treatment option for COVID-19. | 2020-07-03 |
| 32615987 | Due to the severity of the disease, invasive mechanical ventilation was instituted and SARS-CoV-2 treatment (azithromycin 250 mg once-daily and hydroxychloroquine 200 mg trice-daily) started. | 2020-07-04 |
| 32616030 | The immunosuppressive state induced by liver transplantation and anti-rejection therapy might contribute to the severity of COVID-19 in Case 4, who suffered from hepatitis B related hepatocellular carcinoma. […] However, Case 4 was recovered from COVID-19 after a combination therapy against virus, bacteria and fungi, and also respiratory support. […] And the treatment of SARS-CoV-2 infection in cancer patients is challenged by the immunosuppressive state of these patients under chemotherapy or surgery. | 2020-07-04 |
| 32616063 | To describe the effects of maternal SARS-CoV-2 infection on pregnancy and perinatal outcomes by treatment group. […] Participants will be randomized to receive a 14-day oral treatment course of HCQ or placebo, ratio 1:1. […] The primary outcome is the number of PCR-confirmed infected pregnant women assessed from collected nasopharyngeal and oropharyngeal swabs at day 21 after treatment start (one week after treatment is completed). […] Each number will be related to a treatment number, which assigns them to one of the study arms. | 2020-07-04 |
| 32616067 |
|
2020-07-04 |
| 32616077 | All-cause mortality was 10% overall (95% PI, 2 to 39%; 1687/14203 patients; 43 studies), 34% in patients admitted to intensive care units (95% PI, 8 to 76%; 659/2368 patients; 10 studies), 83% in patients requiring invasive ventilation (95% PI, 1 to 100%; 180/220 patients; 6 studies), and 75% in patients who developed ARDS (95% PI, 35 to 94%; 339/455 patients; 11 studies). | 2020-07-04 |
| 32616134 | Methods Totally 63 discharged patients in Wuhan,China,who underwent both chest CT and reverse transcription-polymerase chain reaction(RT-PCR)from February 1 to February 29,2020,were included.With RT-PCR as a gold standard,the performance of chest CT in diagnosing COVID-19 was assessed.Patients were divided into mild/moderate and severe/critical groups according to the disease conditions,and clinical features such as sex,age,symptoms,hospital stay,comorbidities,and oxygen therapy were collected.CT images in the recovery phase were reviewed in terms of time from onset,CT features,location of lesions,lobe score,and total CT score. […] 53.85%; χ2=18.90, P<0.001), lower nasal oxygen therapy ratio (81.08% vs. | 2020-07-04 |
| 32616381 | The viral infection by SARS-CoV-2 has irrevocably altered the life of the majority of human beings, challenging national health systems worldwide, and pushing researchers to rapidly find adequate preventive and treatment strategies. | 2020-07-04 |
| 32616498 | The COVID-19 global pandemic has drastically impacted cancer care, posing challenges in treatment and diagnosis. […] There is increasing evidence that cancer patients, particularly those who have advanced age, significant comorbidities, metastatic disease, and/or are receiving active immunosuppressive therapy may be at higher risk of COVID-19 severe complications. […] Universal testing of asymptomatic cancer patients may be key to ensure safe continuation of treatment and appropriate hospitalized patients cohorting during the pandemic. | 2020-07-04 |
| 32616524 | Therefore, we described the clinical characteristics, laboratory features, treatment and outcomes of CVD complicating SARS-CoV-2 infection. […] Of 10 patients with ischemic stroke; 6 received antiplatelet treatment with aspirin or clopidogrel; and 3 of them died. […] The other four patients received anticoagulant treatment with enoxaparin and 2 of them died. | 2020-07-04 |
| 32616594 | While severe coronavirus infections, including Middle East respiratory syndrome coronavirus (MERS-CoV) cause lung injury with high mortality rates, protective treatment strategies are not approved for clinical use. […] We elucidated the molecular mechanisms by which the cyclophilin inhibitors Cyclosporin A (CsA) and Alisporivir (ALV) restrict MERS-CoV to validate their suitability as readily-available therapy in MERS-CoV infection. | 2020-07-04 |
| 32616970 | Methods The present is a retrospective study describing three protocols: 1) reduction in the risk of infection for patients and healthcare workers; 2) adaptation of work, academic and scientific activities; and 3) adaptation of the orthopedic treatment during the pandemic. […] The protocols focused on reducing the risk of infection for patients and healthcare professionals, adapting work, academic and scientific activities, and modifying the orthopedic treatment. | 2020-07-04 |
| 32617048 | However, it must be kept in mind that these patients also need surgical treatment, and the delay time should not cause a negative effect on the surgical outcome or disease process. | 2020-07-04 |
| 32617049 | Cancer patients are at a significantly higher risk of getting infected with COVID-19 since their immune system can be compromised and that reality has to do with both that they have cancer and that they are on therapy for their cancer. […] We should make sure cancer patients on active treatment are treated appropriately. […] In this review, we tried to explain how to prevent the negative effects of the COVID-19 pandemic on the diagnosis and treatment of breast cancer patients. | 2020-07-04 |
| 32617050 | In this study, we analyzed the treatment processes of our patients with malignancy that underwent a surgical oncological procedure during this pandemic. | 2020-07-04 |
| 32617169 | One such medication includes the antimalarial hydroxychloroquine (HCQ), which recently reported as a possible therapy for shortening the duration of COVID-19 symptoms, reducing inflammatory reactions to infection, impairing the exacerbation of pneumonia and boosting lung imaging findings. | 2020-07-04 |
| 32617220 | Background/Aims Novel coronavirus disease 2019 (COVID-19) is a global challenge due to little available knowledge and treatment protocols. | 2020-07-04 |
| 32617313 | The unique pathophysiology of COVID-19 requires the customization of therapy by individual patient characteristics and according to the phase-specific, evolving derangement of the multiple biological pathways. | 2020-07-04 |
| 32617402 | Results Our IBD Unit, with up to 1,500 IBD patients receiving biotechnological or experimental therapy, represents a high-volume Italian and European IBD center. […] Specific strategies have been designed to guarantee a high level of safety for both patients with IBD and healthcare personnel dedicated to their treatment. | 2020-07-04 |
| 32617527 | Currently, there is no specific treatment against the new virus. | 2020-07-04 |
| 32617611 | These problems continue to exist even after months of the covid-19 crisis.The Nursing Section of the DGIIN expressly declares its willingness to actively and constructively participate in any processes in the future and, with the following 5 points, offers initial practical assistance to improve the situation in German intensive care units. | 2020-07-04 |
| 32617666 | There is no difference in ophthalmological treatment between SARS-CoV‑2 positive and other intensive care patients. | 2020-07-04 |
| 32617738 | Patients with ODs less frequently needed oxygen therapy. | 2020-07-04 |
| 32617968 | Drug treatment for acute pulpitis was used more often in 2020 than in 2019, and endodontic treatment and examination consultations were less common in 2020 than in 2019 (P = 0.022). | 2020-07-04 |
| 32617984 | The main purpose of this article is to discuss how orthopedic oncology clinics should be organized during the pandemic and to present the process management scheme for patients requiring orthopedic surgery, including trauma surgery, from diagnosis to treatment, together with our experiences. […] The early identification, strict isolation, and effective treatment of these patients prevented any nosocomial infections and disease-related comorbidities. | 2020-07-04 |
| 32617986 | Demographic, clinical, laboratory, and treatment data were presented using descriptive statistics and frequencies. […] Inpatient mortality occurred in 70% who needed mechanical ventilation (OR: 29.51; 95% CI: 13.28-65.60; P < .0001), 58% who required continuous renal replacement therapy/hemodialysis (CRRT/HD) (OR: 6.63; 95% CI: 2.74-16.05; P < .0001), and 69% who needed vasopressors (OR: 30.64; 95% CI: 13.56-69.20; P < .0001). | 2020-07-04 |
| 32617987 | A number of potential drugs/vaccines as well as antibody/cytokine-based therapeutics are in various developmental stages of preclinical/clinical trials against SARS-CoV, MERS-CoV, and 2019-nCoV with substantial cross-reactivity, and may be used against COVID-19. […] This review comprehensively summarizes the recent reports available regarding the host-pathogen interaction, morphological and genomic structure of the virus, and the diagnostic techniques as well as the available potential therapeutics against COVID-19. | 2020-07-04 |
| 32618198 | Since DPP4-inhibitors are currently used for the treatment of patients with type-2 diabetes (T2DM), there is currently high interest in the possibility that these agents, or incretin-based therapies (IBTs) in general, may be of benefit against the new coronavirus infection. […] Further research into prognostic variables associated with various antidiabetic treatment regimens, and in particular the IBT, in patients with T2DM affected by the COVID-19 pandemic is therefore warranted. | 2020-07-04 |
| 32618260 | Our understanding of SARS-CoV-2, the virus responsible for coronavirus disease 2019 (COVID-19), its clinical manifestations, and treatment options continues to evolve at an unparalleled pace. […] A clear definition of a COVID-19 case is essential for the management, treatment, and tracking of clinical illness, and to inform the quarantine measures and social distancing that can help control the spread of SARS-CoV-2. | 2020-07-04 |
| 32618402 | There is a growing concern regarding how patients on immunosuppressant biologic therapies might be at higher risk of being infected and whether they need to discontinue their treatment preemptively. | 2020-07-04 |
| 32618463 | Since COVID-19 disease was declared by the WHO there has been a redistribution of the healthcare system for these types of patients, especially in the front line, which is, in primary care, emergencies and in intensive care units (ICU). […] ARDS’s treatment strategies include pulmonary protection ventilation, prone position, recruitment maneuvers and, less frequently, oxygenation by extracorporeal membrane. | 2020-07-04 |
| 32618658 | Epidemiological, demographic, clinical, laboratory, treatment, and outcome data were collected and compared. | 2020-07-04 |
| 32618700 | Patients with severe acute respiratory syndrome coronavirus 2-related severe acute respiratory distress syndrome requiring venovenous extracorporeal membrane oxygenation therapy with an injected CT scan performed after extracorporeal membrane oxygenation retrieval. | 2020-07-04 |
| 32618746 | Accurate screening and diagnosis of gestational diabetes are critical to treatment, and in a pandemic scenario like coronavirus disease 2019 needing a simple test that minimises prolonged hospital stay. | 2020-07-04 |
| 32618794 | There are limited data regarding treatment options for pregnant women with severe coronavirus disease 2019 (COVID-19). […] Tocilizumab and remdesivir may be effective for treatment of severe COVID-19 in pregnancy, but additional data are needed to guide risk-benefit considerations. | 2020-07-04 |
| 32618909 | These guidelines may be helpful to decrease the infection rate of orthopaedic trauma personnel and to provide diagnosis and treatment therapy for patients with fracture and COVID-19. | 2020-07-04 |
| 32619162 | The current pandemic SARS-CoV-2 has wreaked havoc in the world, and neither drugs nor vaccine is available for the treatment of this disease. […] Thus, there is an immediate need for novel therapeutics that can combat this deadly infection. […] Our data suggest that the p28 has potential as an anti-SARS-CoV-2 agent and can be further exploited to establish its validity in the treatment of current and future SARS-CoV crisis.Communicated by Ramaswamy H. | 2020-07-04 |
| 32619167 | The aim of the present review is to provide basic knowledge about the treatment of Coronavirus via medicinal plants. […] There is currently no specific medicine or vaccine available and it is considered a threat to develop effective novel drug or anti-coronavirus vaccine treatment. […] The view on anti-coronavirus (anti-CoV) activity in the plant derived phytochemicals and medicinal plants give the strong base to develop a novel treatment of corona virus activity. | 2020-07-04 |
| 32619318 | Due to the rapid containment of the prior epidemics, however, these were generally not followed up with in vivo animal studies or clinical investigations and thus largely overlooked as treatment prospects in the current COVID-19 trials. | 2020-07-04 |
| 32619329 | However, D-dimer may not be able to reflect accurate fibrinolysis status of COVID-19 patients, and therefore can’t guide the possible antifibrinolysis or thrombolytic therapy in different stages of COVID-19, as Professor Robert L. | 2020-07-04 |
| 32619669 | In this context, this study aimed to evaluate in silico the molecular interactions of drugs with therapeutic indications for treatment of COVID-19 (Azithromycin, Baricitinib and Hydroxychloroquine) and drugs with similar structures (Chloroquine, Quinacrine and Ruxolitinib) in docking models from the SARS-CoV-2 main protease (M-pro) protein. | 2020-07-04 |
| 32619686 | Based on a survey conducted nationwide, we observed a decrease in the number of emergency cases and cancellation of elective cases, shift to a more conservative treatment approach, use of personal protective equipment, and decrease in the number of outpatient visits and tests. | 2020-07-04 |
| 32619700 | At present, there is no treatment for COVID-19 that is clinically effective, but there is a huge amount of data from studies that analyze potential drugs. | 2020-07-04 |
| 32619760 | Older age (hazard ratio (HR) 0.99, 95% confidence interval (CI) 0.98-1.00; p = 0.04), time lag from illness onset to hospital admission (HR 0.91, 95% CI 0.88-0.94; p < 0.001), diarrhea (HR 0.59, 95% CI 0.36-0.96; p = 0.036), corticosteroid treatment (HR 0.60, 95% CI 0.39-0.94; p = 0.024), and lopinavir/ritonavir use (HR 0.70, 95% CI 0.52-0.94; p = 0.014) were significantly and independently associated with prolonged viral RNA shedding. […] Corticosteroid treatment is associated with prolonged viral RNA shedding and should be used with caution. | 2020-07-04 |
| 32619764 | Data on treatment are scare and parallels have been made between SARS-CoV-2 and other coronaviruses. […] This case series of five COVID-19 patients requiring intensive care unit treatment for respiratory distress and treated with remdesivir, highlights the complexity of remdesivir use in such critically ill patients. | 2020-07-04 |
| 32619884 | We believe that anti-CD20 therapy may jeopardise the efficacy of such a vaccine. […] This is regrettable because patients receiving anti-CD20 therapy (i.e. those with haematologic malignancies or autoimmune disorders) are particularly at risk of severe COVID-19 and, as such, are the most in need of a vaccine. […] Here, we review the reasons why anti-CD20 therapy may abrogate or diminish the efficacy of a vaccine against SARS-CoV-2 and we draw physicians’ attention towards this potential risk so that it can be considered when evaluating the risk/benefit ratio of anti-CD20 therapy during the current pandemic. | 2020-07-04 |
| 32619956 | The clinical features and treatment of COVID-19 patients remain largely elusive. | 2020-07-04 |
| 32619956 | The clinical features and treatment of COVID-19 patients remain largely elusive. | 2020-07-04 |
| 32619956 | The clinical features and treatment of COVID-19 patients remain largely elusive. | 2020-07-04 |
| 32619956 | The clinical features and treatment of COVID-19 patients remain largely elusive. | 2020-07-04 |
| 32619956 | The clinical features and treatment of COVID-19 patients remain largely elusive. | 2020-07-04 |
| 32619956 | The clinical features and treatment of COVID-19 patients remain largely elusive. | 2020-07-04 |
| 32619956 | The clinical features and treatment of COVID-19 patients remain largely elusive. | 2020-07-04 |
| 32619956 | The clinical features and treatment of COVID-19 patients remain largely elusive. | 2020-07-04 |
| 32619956 | The clinical features and treatment of COVID-19 patients remain largely elusive. | 2020-07-04 |
| 32619956 | The clinical features and treatment of COVID-19 patients remain largely elusive. | 2020-07-04 |
| 32619956 | The clinical features and treatment of COVID-19 patients remain largely elusive. | 2020-07-04 |
| 32619956 | The clinical features and treatment of COVID-19 patients remain largely elusive. | 2020-07-04 |
| 32619956 | The clinical features and treatment of COVID-19 patients remain largely elusive. | 2020-07-04 |
| 32619956 | The clinical features and treatment of COVID-19 patients remain largely elusive. | 2020-07-04 |
| 32619956 | The clinical features and treatment of COVID-19 patients remain largely elusive. | 2020-07-04 |
| 32619956 | The clinical features and treatment of COVID-19 patients remain largely elusive. | 2020-07-04 |
| 32619956 | The clinical features and treatment of COVID-19 patients remain largely elusive. | 2020-07-04 |
| 32619956 | The clinical features and treatment of COVID-19 patients remain largely elusive. | 2020-07-04 |
| 32619956 | The clinical features and treatment of COVID-19 patients remain largely elusive. | 2020-07-04 |
| 32619956 | The clinical features and treatment of COVID-19 patients remain largely elusive. | 2020-07-04 |
| 32619956 | The clinical features and treatment of COVID-19 patients remain largely elusive. | 2020-07-04 |
| 32619956 | The clinical features and treatment of COVID-19 patients remain largely elusive. | 2020-07-04 |
| 32619956 | The clinical features and treatment of COVID-19 patients remain largely elusive. | 2020-07-04 |
| 32619956 | The clinical features and treatment of COVID-19 patients remain largely elusive. | 2020-07-04 |
| 32619956 | The clinical features and treatment of COVID-19 patients remain largely elusive. | 2020-07-04 |
| 32619956 | The clinical features and treatment of COVID-19 patients remain largely elusive. | 2020-07-04 |
| 32619956 | The clinical features and treatment of COVID-19 patients remain largely elusive. | 2020-07-04 |
| 32619956 | The clinical features and treatment of COVID-19 patients remain largely elusive. | 2020-07-04 |
| 32619956 | The clinical features and treatment of COVID-19 patients remain largely elusive. | 2020-07-04 |
| 32619956 | The clinical features and treatment of COVID-19 patients remain largely elusive. | 2020-07-04 |
| 32619956 | The clinical features and treatment of COVID-19 patients remain largely elusive. | 2020-07-04 |
| 32619956 | The clinical features and treatment of COVID-19 patients remain largely elusive. | 2020-07-04 |
| 32619956 | The clinical features and treatment of COVID-19 patients remain largely elusive. | 2020-07-04 |
| 32619956 | The clinical features and treatment of COVID-19 patients remain largely elusive. | 2020-07-04 |
| 32619956 | The clinical features and treatment of COVID-19 patients remain largely elusive. | 2020-07-04 |
| 32619956 | The clinical features and treatment of COVID-19 patients remain largely elusive. | 2020-07-04 |
| 32619956 | The clinical features and treatment of COVID-19 patients remain largely elusive. | 2020-07-04 |
| 32619956 | The clinical features and treatment of COVID-19 patients remain largely elusive. | 2020-07-04 |
| 32619956 | The clinical features and treatment of COVID-19 patients remain largely elusive. | 2020-07-04 |
| 32619956 | The clinical features and treatment of COVID-19 patients remain largely elusive. | 2020-07-04 |
| 32619956 | The clinical features and treatment of COVID-19 patients remain largely elusive. | 2020-07-04 |
| 32619956 | The clinical features and treatment of COVID-19 patients remain largely elusive. | 2020-07-04 |
| 32619956 | The clinical features and treatment of COVID-19 patients remain largely elusive. | 2020-07-04 |
| 32619956 | The clinical features and treatment of COVID-19 patients remain largely elusive. | 2020-07-04 |
| 32619956 | The clinical features and treatment of COVID-19 patients remain largely elusive. | 2020-07-04 |
| 32619956 | The clinical features and treatment of COVID-19 patients remain largely elusive. | 2020-07-04 |
| 32619956 | The clinical features and treatment of COVID-19 patients remain largely elusive. | 2020-07-04 |
| 32619956 | The clinical features and treatment of COVID-19 patients remain largely elusive. | 2020-07-04 |
| 32619956 | The clinical features and treatment of COVID-19 patients remain largely elusive. | 2020-07-04 |
| 32619956 | The clinical features and treatment of COVID-19 patients remain largely elusive. | 2020-07-04 |
| 32619956 | The clinical features and treatment of COVID-19 patients remain largely elusive. | 2020-07-04 |
| 32619956 | The clinical features and treatment of COVID-19 patients remain largely elusive. | 2020-07-04 |
| 32619956 | The clinical features and treatment of COVID-19 patients remain largely elusive. | 2020-07-04 |
| 32619956 | The clinical features and treatment of COVID-19 patients remain largely elusive. | 2020-07-04 |
| 32619956 | The clinical features and treatment of COVID-19 patients remain largely elusive. | 2020-07-04 |
| 32619956 | The clinical features and treatment of COVID-19 patients remain largely elusive. | 2020-07-04 |
| 32619956 | The clinical features and treatment of COVID-19 patients remain largely elusive. | 2020-07-04 |
| 32619956 | The clinical features and treatment of COVID-19 patients remain largely elusive. | 2020-07-04 |
| 32619956 | The clinical features and treatment of COVID-19 patients remain largely elusive. | 2020-07-04 |
| 32619956 | The clinical features and treatment of COVID-19 patients remain largely elusive. | 2020-07-04 |
| 32619956 | The clinical features and treatment of COVID-19 patients remain largely elusive. | 2020-07-04 |
| 32619956 | The clinical features and treatment of COVID-19 patients remain largely elusive. | 2020-07-04 |
| 32619956 | The clinical features and treatment of COVID-19 patients remain largely elusive. | 2020-07-04 |
| 32619956 | The clinical features and treatment of COVID-19 patients remain largely elusive. | 2020-07-04 |
| 32620062 | In particular, the off-label use of hydroxychloroquine for COVID-19 prophylaxis and treatment has created many unprecedented challenges for the scientific community and the public. […] We critically assessed major events from February - May 2020 that contributed to widespread use of hydroxychloroquine for the treatment and prophylaxis of COVID-19. | 2020-07-05 |
| 32620144 | The exclusion criteria were: (1) Patients who need ICU management, (2) Positive tests for other pathogens such as Tuberculosis, Mycoplasma, (3) Patients with respiratory failure or requiring mechanical ventilation, (4) Patients with metal implants or pacemakers, (5) Those with shock (6) Those that have bleeding tendency or active bleeding in the lungs, (7) Patients with multiple organ failure who need ICU monitoring and treatment, (8) Cancer patients and those with severe underlying diseases, (9) Pregnant or lactating women, (10) Patients with severe cognitive impairment who cannot follow the instructions to complete the treatment, (11) Those without signed informed consent and (12) Those with other contraindications to short wave. […] The experimental group will be given the nationally recommended standard medical treatment + ultra-short-wave diathermy treatment. […] Ultra-short-wave therapy treatment will be performed through application of ultra-short-wave therapy machine electrodes on the anterior and posterior parts of the trunk for 10 minutes, twice a day for 12 consecutive days. […] The comparator will be the control, not receiving ultra-short-wave therapy, and will be given only the nationally recommended standard medical treatment. | 2020-07-05 |
| 32620174 | As there is no treatment for COVID-19 with a proven mortality benefit at this moment in the pandemic, supportive management including mechanical ventilation is the core management in an intensive care unit (ICU). […] The participants will be recruited from two intensive care units in Canadian Academic Hospitals (one pediatric and one adult ICU). | 2020-07-05 |
| 32620267 | Our tertiary care children’s hospital pivoted towards a brief trial of intravenous (IV) antibiotic therapy in all patients in order to limit operating room (OR) utilization and avoid prolonged hospital stays. | 2020-07-05 |
| 32620315 | The relation of the disease caused by SARS-Cov-2 to immunosuppressive treatment used in different gastrointestinal disorders is uncertain, resulting in debate with regard to suspending immunosuppressive therapy to improve infection outcome. […] Based on the presently available evidence, a treatment stance has been established for patients with gastrointestinal diseases that require immunosuppressive therapy. | 2020-07-05 |
| 32620366 | This could help understand the susceptibility of urological patients, especially those receiving androgen deprivation therapy for prostate cancer, and testosterone replacement therapy. | 2020-07-05 |
| 32620409 | Convalescent Plasma (CP) therapy is of interest as no vaccine or specific treatment is available for emerging viruses such as severe acute respiratory syndrome coronavirus 2 causing Covid-19. […] It was aimed to report the results of our patients who underwent CP in the treatment of Covid-19. […] CP treatment was applied to 26 Covid-19 patients in intensive care unit who had quantitative reverse transcriptase-polymerase chain reaction positive Sars-Cov-2 infection. […] CP therapy has the potential to provide immediate and promising treatment options before specific vaccines and treatments are developed. […] In early stage Covid-19 patients who do not need mechanical ventilation, CP treatment may be a curative treatment option. | 2020-07-05 |
| 32620465 | Currently, the COVID-19 pandemic is affecting the continuity of essential routine healthcare services and procedures, including chimeric antigen receptor T-cell (CAR-T) therapy, a life-saving option for patients with relapsed/refractory (R/R) hematologic malignancies. […] However, CAR-T treatment has become extraordinarily challenging during this COVID-19 pandemic. […] Thus, many medical and technical factors must now be taken into consideration before, during, and after CAR-T therapy. […] The purpose of this review is to provide brief suggestions for rational decision-making strategies in evaluating and selecting CAR T-cell treatment and appropriate CAR T-cell products, and protective strategies for medical staff and patients to prevent infection in the midst of the current COVID-19 pandemic. | 2020-07-05 |
| 32620487 | The authors recommend the preemptive placement of central venous lines in high-risk patients with intravenous tubing extensions that allow for medication delivery from outside the patients’ rooms. | 2020-07-05 |
| 32620549 | Faecal microbiota transplantation (FMT) has a well-established role in the treatment of Clostridioides difficile infection. | 2020-07-05 |
| 32620591 | The need to don higher-level PPE has to be weighed against the resulting delay to emergency treatment.We performed a literature search on this topic which found eight relevant studies. | 2020-07-05 |
| 32620597 | Median time to clinical improvement in patients with lung consolidation <17% was shorter after sarilumab (10 days) than after standard treatment (24 days; p=0.01). | 2020-07-05 |
| 32620678 | The measures to control the COVID-19 outbreak will likely remain a feature of our working lives until a suitable vaccine or treatment is found. | 2020-07-05 |
| 32620682 | A Treatment Escalation Plan of ward-based care was put in place and the palliative care team involved. […] The validated COVID-GRAM calculator predicted a greater than 99% risk that this patient would require intensive therapy unit admission or die. | 2020-07-05 |
| 32621065 | Although only a limited proportion of COVID-19 patients develop respiratory or circulatory failure that is refractory to conventional treatment, it is of utmost importance to clearly define criteria for the use of ECMO in this steadily growing patient population. | 2020-07-05 |
| 32621109 | Little is known, at the country level, where and how patients on renal replacement therapy (RRT) have been mostly affected. […] The proportion of SARS-CoV-2 positive RRT patients in Italy was 2.26% (95% CI 2.14-2.39) with significant differences according to treatment modality (p < 0.001). […] Infection risk and rates seems to differ substantially across regions, along geographical latitude, and by treatment modality. | 2020-07-05 |
| 32621178 | With advances in diagnosis, treatment, and transfusion support, the prognosis of patients with thalassemia has improved over the past few decades. | 2020-07-05 |
| 32621202 | Patients on anti-hypertensive treatment with or without ACEI/ARB were compared on their clinical characteristics and outcomes. […] Among the 101 patients with a history of hypertension and taking at least one anti-hypertensive medication, 40 patients were receiving ACEI/ARB as part of their regimen, and 61 patients were on antihypertensive medication other than ACEI/ARB. […] 26%, P = 0.31) between patients with or without ACEI/ARB treatment. […] Further multivariable adjustment of age and gender did not provide evidence for a significant association between ACEI/ARB treatment and severe COVID-19 outcomes. […] Patients should continue previous anti-hypertensive therapy until further evidence is available. | 2020-07-05 |
| 32621206 | However, the hepatic injury could be due to a consequence of systemic inflammatory response, viral infection of hepatocytes, or as a result of intensive care treatment or drug toxicity. | 2020-07-05 |
| 32621238 | Yet, chest CT is often used in patients with known or suspected COVID-19 due to regional preferences, lack of availability of PCR assays, and false-negative PCR assays, as well as for monitoring of disease progression, complications, and treatment response. | 2020-07-05 |
| 32621284 | Herein, we attempt to identify potentially safe immunotherapies that may be used in the treatment of cutaneous diseases during the current COVID-19 pandemic. […] Furthermore, reported risk of infections of biologic and non-biologic therapeutics for skin diseases from clinical trials and drug data registries were evaluated. | 2020-07-05 |
| 32621312 | As a result, her therapy is shaped in such a way that she tends to raise more questions instead of providing answers. | 2020-07-05 |
| 32621371 | Therefore, recommendations for navigating affair recovery during the pandemic, including adaptations for therapy, are also discussed. | 2020-07-05 |
| 32621462 | Based on the experience of other countries that have already encountered the massive spread of COVID-19, the author presents a review of the proposed urgent and preventive organizational and treatment measures and suggests practical recommendations on urgent temporary reorganization of the psychiatric service, and the provision of psychological and psychotherapeutic support to the most vulnerable groups of the population, including medical personnel working with patients with COVID-19, and the management of mentally ill patients with severe acute respiratory syndrome. […] Particular attention is paid to the management of mentally ill patients with coronavirus respiratory syndrome and the characteristics of psychopharmacological therapy with an overview of the potential risks of side-effects and complications related primarily to respiratory function, including those due to adverse drug interactions. | 2020-07-05 |
| 32621481 | Recommendations for anxiety adjustment disorders psychopharmacotherapy with the use of tranquillizers as treatment of choice are given. | 2020-07-05 |
| 32621523 | Among the 5 OHT patients, 2 of 5 (20%) had mild disease and had no change in baseline immunosuppression therapy. […] Two of 5 (20%) had moderate disease and received remdesivir as part of a clinical trial and reduced immunosuppression therapy. | 2020-07-05 |
| 32621628 | The pandemic made concerns, especially about immunosuppressive therapy. | 2020-07-05 |
| 32621718 | The novel compound nCorv- EMBS herein proposed stands as a promising inhibitor to be evaluated further for COVID-19 treatment. | 2020-07-05 |
| 32621728 | However, CT has been found to have limited sensitivity and negative predictive value in the early stages of the disease, and the value of its use has come under debate due to whether its images change the treatment plan, the risk of radiation, as well as its practicality with infection control. | 2020-07-05 |
| 32621814 | Rapid and early laboratory diagnosis of COVID-19 is the main focus of treatment and control. | 2020-07-05 |
| 32621881 | There is limited data regarding the electrophysiological abnormalities and arrhythmias in children with COVID-19, including those associated with treatment using potentially proarrhythmic hydroxychloroquine (HCQ) and azithromycin (AZN). […] To describe the electrophysiologic findings and arrhythmias associated with pediatric COVID-19 and its treatment. […] All were self-resolving and half prompted prophylactic antiarrhythmic therapy. […] COVID-19 treatment using HCQ is associated with QTc prolongation but was not associated with arrhythmias in pediatric patients. | 2020-07-05 |
| 32622261 | The rapid and global spread of a new human coronavirus (SARS-CoV-2) has produced an immediate urgency to discover promising targets for the treatment of COVID-19. […] Here, we review current information concerning the global health issue of COVID-19 including promising approved drugs and ongoing clinical trials for prospective treatment options. | 2020-07-05 |
| 32622338 | We report a series of two MS patients who developed COVID-19 while on Ocrelizumab therapy and subsequently exhibited negative SARS-CoV-2 serology. […] A 42-year-old man and 39-year-old woman with MS developed COVID-19 while on Ocrelizumab therapy. | 2020-07-05 |
| 32622450 | Despite the issuance of emergency use authorization for remdesivir, there are still no proven effective antiviral and immunomodulatory therapies, and their use in COVID-19 management should be guided by clinical trial protocols or treatment registries. | 2020-07-06 |
| 32622469 | Furosemide is a “repurpose-able” small molecule therapeutics, that is safe, easily synthesized, handled, and stored, and is available in reasonable quantities worldwide. | 2020-07-06 |
| 32622684 | The modified Buda scoring system for interstitial lung disease was used to evaluate the severity and treatment effect of COVID-19 on ultrasonography. […] MLUS scores (Z = 2.61, p = 0.009) and HRCT Warrick scores (Z = 2.63, p = 0.009) of five severe or critical COVID-19 patients significantly decreased as their conditions improved after treatment. […] The MLUS scoring system could be used to evaluate the severity and treatment effect of COVID-19. | 2020-07-06 |
| 32622730 | Societal measures in context of the COVID-19 outbreak forced us to transform our schema therapy based day-treatment for older adults with chronic affective disorders and personality problems into an online program. […] Using over-the-phone instructions initially, all patients were able to participate with the online therapy program. […] Sending homework by email and mail seems to facilitate therapy adherence. […] Nonverbal therapy could be important to stimulate the online group process. | 2020-07-06 |
| 32622963 | Mesenchymal stem/stromal cells (MSCs) have been tested during the last two decades for the treatment of various pathologic conditions, including acute and chronic lung diseases, both in animal models and in patients. […] In particular, promising results have been obtained in the experimental therapy of acute respiratory distress syndrome, which represents the most threatening complication of COVID-19 infection. | 2020-07-06 |
| 32622993 | (Hydroxy)chloroquine ((H)CQ) is being investigated as a treatment for COVID-19, but studies have so far demonstrated either no or a small benefit. […] Another suggested approach uses prophylactic (H)CQ treatment aimed at preventing either severe acute respiratory syndrome coronavirus 2 infection or the development of disease. […] This review provides an overview of the current evidence on (H)CQ therapy in patients with COVID-19 and discusses different strategies for prophylactic (H)CQ therapy (ie, preinfection, postexposure, and postinfection). | 2020-07-06 |
| 32623036 | All respondents reported that one of the main fear was to “be infected and not to receive adequate treatment” and/or “getting infected if going to the hospital or medical appointments”. | 2020-07-06 |
| 32623038 | Therefore, we review the current knowledge of COVID-19 including the global and regional epidemiology, virology, impact of diabetes on COVID-19, treatment of COVID-19, and standard of care in the management of diabetes during this critical period. | 2020-07-06 |
| 32623041 | COVID-19 has significantly impacted the daily lives of individuals living with diabetes through financial implications, food and medication scarcity and its burden on mental health. | 2020-07-06 |
| 32623082 | Currently there is no known effective therapy or vaccine for treatment of SARS-CoV-2, highlighting urgency around identifying effective therapies. […] The purpose of this study was to evaluate the role of hydroxychloroquine therapy alone and in combination with azithromycin in hospitalized patients positive for COVID-19. […] Overall in-hospital mortality was 18.1% (95% CI:16.6%-19.7%); by treatment: hydroxychloroquine+azithromycin, 157/783 (20.1% [95% CI: 17.3%-23.0%]), hydroxychloroquine alone, 162/1202 (13.5% [95% CI: 11.6%-15.5%]), azithromycin alone, 33/147 (22.4% [95% CI: 16.0%-30.1%]), and neither drug, 108/409 (26.4% [95% CI: 22.2%-31.0%]). […] Hydroxychloroquine provided a 66% hazard ratio reduction, and hydroxychloroquine+azithromycin 71% compared to neither treatment (p<0.001). […] In this multi-hospital assessment, when controlling for COVID-19 risk factors, treatment with hydroxychloroquine alone and in combination with azithromycin was associated with reduction in COVID-19 associated mortality. | 2020-07-06 |
| 32623083 | A comprehensive strategy - including surveillance, diagnostics, research, and clinical treatment - is urgently needed to win the battle against COVID-19. | 2020-07-06 |
| 32623176 | Till date no medication or vaccine is available to cope with the COVID-19 infection and infection rate is increasing drastically across the globe. | 2020-07-06 |
| 32623296 | This review is dedicated to the optimization of care pathways and therapeutics in cancer patients during the pandemic and aims to discuss successive issues. […] First we focused on the international guidelines proposing adjustments and alternative options to cancer care in order to limit hospital admission and cytopenic treatment in cancer patients, most of whom are immunocompromised. | 2020-07-06 |
| 32623357 | These molecules can be further tested to speed the development of therapeutics against COVID-19. | 2020-07-06 |
| 32623480 | While several countries have chosen the almost complete lock-down for slowing down SARS-CoV-2 spread, the scientific community is called to respond to the devastating outbreak by identifying new tools for diagnosis and treatment of the dangerous COVID-19. | 2020-07-06 |
| 32623500 | Demographic survey data, change of clinical practice, current performance of procedures, and current commencement of treatment for 5 conditions in medical urological oncology were evaluated. 235 urologists from 44 countries responded. […] (Neo)adjuvant/palliative treatment is currently not started by more than half of the urologists. […] COVID-19 high-risk-countries had higher total cancellation rates for non-oncological procedures (78% vs. 68%, p = 0.01) and were performing oncological treatment for metastatic diseases at a lower rate (35% vs. 48%, p = 0.02). […] The impact of implementing surgical prioritization protocols with moderate cancellation rates for oncological surgeries and delay or reduction in (neo)adjuvant/palliative treatment will have to be evaluated after the pandemic. | 2020-07-06 |
| 32623963 | Accurate and early detection of infectious pathogens are crucial for transmission control, clinical diagnosis, and therapy. | 2020-07-07 |
| 32624303 | In this review, we review the cardiovascular manifestations of COVID-19 and describe our system-wide adaptations to the pandemic, including the use of telemedicine, how a severe reduction in operative volume affected our program, the process of redeployment of staff, repurposing of residents into specific task teams, the creation of operation room intensive care units, and the challenges that we faced in this process. | 2020-07-07 |
| 32624376 | Ayurvedic clinical profiling of COVID-19 is a pre-requisite to develop standalone and integrative treatment approaches. | 2020-07-07 |
| 32624494 | In a substantial number of patients, adequate arterial oxygenation cannot be achieved with supplementary oxygen therapy alone. […] These results suggest that ward-based NIPS should be considered as a treatment option in an integrated escalation strategy in all units managing respiratory failure secondary to COVID-19. | 2020-07-07 |
| 32624690 | Based on clinical presentation, pathophysiology, high infectivity, high cardiovascular involvement, and therapeutic agents with cardiovascular toxicity of coronavirus disease 2019 (COVID-19), regular cardiovascular treatment is being changing greatly. […] Fibrinolytic therapy can be considered a reasonable option for the relatively stable ST segment elevation myocardial infarction (STEMI) patient with suspected or known COVID-19. | 2020-07-07 |
| 32625198 | Likewise, the repurposing of antimalarials for treatment of COVID-19 shared symptoms and the shift in focus from the production of malaria rapid diagnostic tests (RDTs) to COVID-19 RDTs is a cause for concern in malaria-endemic regions. […] However, due to the fears of contracting SARS-CoV-2, the elderly who are worst affected by COVID-19 may not take children for malaria medication, resulting in high malaria-related mortalities among children. | 2020-07-07 |
| 32626626 | The instrumental role of recombinant ACE2, AT2 receptor agonists, and AT1 receptor blockers may be helpful in the treatment of COVID-19. | 2020-07-07 |
| 32626870 | Based on the normative standards issued by the National Health Commission of China, consensus on clinical trial management formulated by the organization of clinical research, and regulations for the diagnosis and treatment of oral diseases during public health emergencies by Chinese Stomatological Association, we drafted the guideline for clinical research of oral diseases, with a view to provide reference for the clinical studies of oral diseases under the first level response to major public health emergencies. | 2020-07-07 |
| 32626871 | For these three problems, we invited the experts from the Society of Oral Medicine, Shanghai Stomatological Association and the Oral Mucosal Disease Specialist Alliance Organization of Shanghai Ninth People’s Hospital Group to write the recommendation on the diagnosis and treatment of oral mucosal disease during prevention and control stage of novel coronavirus infection, in order to provide references for oral mucosal disease medical physicians and patients in this special period. […] This recommendation will be updated according to the situation of epidemic prevention and control in China and the new relevant diagnosis and treatment plans. | 2020-07-07 |
| 32626872 | During the epidemic period of COVID-19, due to the particularity of diagnosis and treatment of oral diseases, there is great challenges for how to deal with various types of dental emergency. […] In order to prevent and control the epidemic situation strictly, and to perform a scientific and orderly clinical diagnosis and treatment of dental emergency, this article provided suggestions on personnel management training, procedures and treatment, protection and disinfection of dental emergency during COVID-19 epidemic, and reference for dental institutions and medical staff. | 2020-07-07 |
| 32627127 | Currently, there is no robust clinical evidence for the use of these drugs in the treatment of COVID-19, with most, if not all of these medications associated with the potential for QT interval prolongation, torsades de pointes, and resultant drug-induced sudden cardiac death. | 2020-07-07 |
| 32627205 | Intention-to-treat analyses and average-treatment-effect-on-the-treated estimations confirmed that Questionnaire 1 could motivate SWBDs to actually donate blood. | 2020-07-07 |
| 32627330 | This raised concern about the potential association between hypertension (and its treatment) and propensity for COVID-19. | 2020-07-07 |
| 32627442 | Although convalescent plasma (CP) therapy can be useful in the treatment of COVID-19, it has not been widely used in Korea because of the concerns about adverse effects and the difficulty in matching patients to donors. […] The use of ABO-incompatible plasma is not contraindicated in treatment, but can be hesitated due to the lack of experience of physicians. […] Here, we describe a 68-year old man with COVID-19 who was treated ABO-incompatible plasma therapy; additionally, we comment on the acute side effects associated with ABO mismatch transfusion. […] We suggest that experience gained in CP therapy will be useful for not only the treatment of COVID-19, but also for coping with new emerging infectious diseases. | 2020-07-07 |
| 32627515 | Although administration of immunomodulatory drugs is recommended under certain conditions by the guidelines for COVID‑19 management, controversies regarding treatment protocols in immunocompromised patients infected with SARS‑CoV‑2 still exist. | 2020-07-07 |
| 32627534 | To contain those viruses, accurate and fast diagnosis followed by effective isolation and treatment of patients are pivotal at the early stage of virus breakouts. | 2020-07-07 |
| 32627622 | The article reflects the main types of TMA, pathogenesis and principles of therapy. […] Through a deeper understanding of pathogenesis, it will be possible to develop more effective diagnosis and therapy. | 2020-07-07 |
| 32627963 | It is recommended that all thoracic cancer patients should be offered treatment according to the accepted standard of care until shortage of services require a progressive reduction in surgical cases. | 2020-07-07 |
| 32628003 | Within 14 days of treatment, 29% of patients had clinical improvement, 20% had minimal or no improvement, 17% worsened, 27% died, and 7% were transferred to an outside hospital. | 2020-07-07 |
| 32628131 | Some patients reported an alteration of medication regimens during the epidemic. | 2020-07-07 |
| 32628248 | There are currently no widely accepted evidence-based guidelines regarding specifics related to treatment and prevention of COVID-19-related coagulopathies. […] Areas of management requiring clinical equipoise include agent selection and dosing, continuation vs interruption of home oral anticoagulant therapy during hospital admission, and postdischarge VTE prophylaxis. | 2020-07-07 |
| 32628399 | Advances in early diagnosis and treatment of diseases using minimally invasive procedures has led to an increase in the number of cases in locations outside the operating room. | 2020-07-07 |
| 32628416 | In the absence of available vaccines or antiviral therapies, symptomatic and respiratory support is the current standard of therapy. | 2020-07-07 |
| 32628591 | Therefore, MSCs therapy could be game charges in the treatment of the current COVID-19 pandemic. […] It is important to indicate that, these medication does not target the virus itself. | 2020-07-07 |
| 32629084 | The coronavirus disease 2019 (COVID-19) crisis has amplified the importance of palliative care to countless patients suffering with and dying from this disease, as well as to their families, communities, and the worldwide cadre of overburdened health care workers. […] Although spiritual care has long been recognized as one of the domains of quality palliative care, it is often not fully integrated into practice. […] Although the pandemic has revealed serious fault lines in many health care domains, it has also underscored the need to recommit to spiritual care as an essential component of whole-person palliative care. | 2020-07-07 |
| 32629085 | The lymphocyte count after ciclesonide treatment in the non-severe pneumonia group was significantly higher (p = 0. 0156) than before. […] Treatment with ciclesonide may prevent the development of severe COVID-19. | 2020-07-07 |
| 32629100 | The optimal management of respiratory failure and the role of lung ultrasound imaging in the evaluation of efficacy of treatment are unknown. […] In March 2020 we treated 18 patients with mild and moderate ARDS secondary to SARS-CoV-2 with non-invasive continuous positive airway pressure therapy (NI-CPAP). […] After one hour of treatment we observed a significant improvement in PaO2/FiO2 ratio in 10 patients. | 2020-07-07 |
| 32629115 | All evidence-based treatment strategies need to be considered to combat this new virus. […] Chloroquine (CQ) and hydroxychloroquine (HCQ) are old drugs used in the treatment of malaria. […] These could be integrated into current treatment strategies while novel treatments are awaited, also in light of the fact that they display an anticoagulant effect that facilitates the activity of low-molecular-weight heparin, aimed at preventing acute respiratory distress syndrome (ARDS)-associated thrombotic events. | 2020-07-07 |
| 32629187 | The first method involves incubating the specimen with proteinase K, and then heat treatment at 98 °C for 5 min (PKH); the second method involves heat treatment at 98 °C for 5 min without proteinase K pre-incubation (heat only); the third method involves no pre-processing steps (direct). | 2020-07-07 |
| 32629273 | Hence, the proposed measures include decentralization of wastewater treatment facilities, community-wide monitoring and testing of SARS-CoV-2 in wastewater samples, improved sanitation, developing point-of-use devices for wastewater decontamination, and more focused policy interventions. | 2020-07-07 |
| 32629402 | The cases involved a combination of relapsing and progressive MS phenotypes treated with a range of DMT (5 anti CD20 therapy, 4 cladribine, 4 fingolimod, 4 injectables, 3 alemtuzumab, 2 dimethyl fumarate, 2 untreated, 1 teriflunomide, 1 natalizumab). | 2020-07-07 |
| 32629531 | The selective JAK1/2 inhibitor ruxolitinib has shown promising results in the context of GVHD, and different trials are currently underway in patients with severe COVID-19; nevertheless, no clinical observation of safety or efficacy of treatment with ruxolitinib in this context has been published yet. […] We describe a first case of severe COVID-19 developed after hematopoietic stem cell transplantation in a patient with a concomitant chronic GVHD (cGVHD), in which a treatment with ruxolitinib was administered with good tolerance and positive outcome. | 2020-07-07 |
| 32629539 | As the COVID-19 pandemic continues to claim lives across the globe, insufficient data exists regarding the optimal treatment. | 2020-07-07 |
| 32629642 | Our present findings will indicate the application of acupuncture as an adjunctive treatment for dyspnea in COVID-19, which will be published in a peer-reviewed journal. […] Our study will provide a reference foundation for clinical optimization of treatment. | 2020-07-08 |
| 32629670 | With active antiviral and noninvasive respiratory supportive therapy, there was no improvement, thus mechanical ventilation (MV) was adopted. […] Combining with symptomatic and supportive treatment, their oxygenation recovered and then extubation was carried out. […] Initial Strategy for respiratory failure included endotracheal intubation, MV, antiviral treatment and cortisol in both cases. […] Later, veno-venous extracorporeal membrane oxygenation was performed owing to aggravation of respiratory failure, assisted by prone position treatment and sputum drainage, then status became stable and stepped into recovery stage. […] Through prone position treatment, sputum drainage and awake extracorporeal membrane oxygenation strategy, patient has been transferred to rehabilitation unit in Case 1, and patient in Case 2 has been in recovery stage as well with stable pulmonary status and was expected to receive evaluation in recent future. | 2020-07-08 |
| 32629703 | The treatment was mainly supportive and the patient was intensively monitored. […] The patient took continuous renal replacement therapy (CRRT) every 2 days. […] The courses of disease and treatment options for this individual were significantly more complicated than those for ordinary patients. […] Compared with other severe COVID-2019 cases, this patient recovered more quickly following treatment, which was likely due to the removal of inflammatory mediators by CRRT. | 2020-07-08 |
| 32629768 | In our opinion, despite the controversial results of an important randomized clinical trial, and some recommendations, clinicians should not abandon the use of LPV/r for the treatment of COVID-19, possibly using this drug inside a prospective randomized trial, waiting for the results of the numerous ongoing trials evaluating its efficacy. | 2020-07-08 |
| 32629788 | We here describe the course and the outcome of COVID-19 in a cohort of patients undergoing treatment with calcineurin inhibitors. […] Patients were followed at our hospital for solid organ transplantation or systemic rheumatic disorders (RMDs) and were on calcineurin inhibitor (CNI)-based therapy. | 2020-07-08 |
| 32629804 | To identify therapeutics that might be repositioned for treatment of the SARS-CoV-2 disease COVID-19, we strategically reviewed the literature to identify existing therapeutics with evidence of efficacy for the treatment of the three coronaviruses that cause severe respiratory illness (SARS-CoV, MERS-CoV, and SARS-CoV-2). […] Therapeutics with particularly high potential efficacy for repurposing include camostat mesylate, remdesivir, favipiravir, tocilizumab, baricitinib, convalescent plasma, and humanized monoclonal antibodies. | 2020-07-08 |
| 32629817 | Lack of effective conventional treatment of this septic state has spiked an interest in alternative medicine. | 2020-07-08 |
| 32629875 | Neither curative anti-viral drugs nor a protective vaccine is currently available for the treatment and prevention of COVID-19. | 2020-07-08 |
| 32630032 | These could be co-caused by COVID-19, prolonged bed rest, the complex medical nutritional therapy, and the starting condition of low-grade inflammation of the obese. […] The assessment of nutritional status, with body composition applied to imaging diagnostics and metabolic profiles in COVID-19, will assist in prescribing appropriate medical nutritional therapy. | 2020-07-08 |
| 32630111 | Probiotic preparations of Saccharomyces are broadly used for the prevention of antibiotic-associated complications, especially in the intensive care units (ICU). | 2020-07-08 |
| 32630212 | Specific immunomodulatory therapy depends on the clinical presentation. | 2020-07-08 |
| 32630746 | A detailed pharmacological description of the novel potential anti-COVID-19 therapeutics was also included. | 2020-07-08 |
| 32631083 | Chloroquine (CQ) and hydroxychloroquine (HCQ) originally were prescribed for prevention or treatment of malaria, but now successfully are used in several rheumatologic diseases. […] HCQ/CQ showed acceptable efficacy in HIV especially as an adjuvant treatment beside routine HAART. | 2020-07-08 |
| 32631130 | A 3-month pilot randomized controlled trial was conducted to compare the mobile interventionist approach as an add-on to assertive community treatment (ACT) versus ACT alone. […] Clinical outcomes were evaluated at baseline, posttreatment, and 6-month follow-up, and satisfaction was evaluated posttreatment. […] Exploratory posttreatment clinical effect estimations suggested greater reductions in the severity of paranoid thoughts (Cohen’s d=-0.61) and depression (d=-0.59) and improved illness management (d=0.31) and recovery (d=0.23) in the mobile interventionist group. | 2020-07-08 |
| 32631317 | The evaluation of clinical response to therapy was based on chest CT scan. […] Serum LDH was validated for its potential usefulness as markers for evaluating clinical severity and monitoring treatment response in COVID-19 pneumonia. | 2020-07-08 |
| 32631393 | Critically ill adult patients admitted to intensive care units (ICUs) from 3 hospitals in Wuhan, China, were included. | 2020-07-08 |
| 32631405 | We are conducting this study in patients with COVID-19 admitted to intensive care units at the Imam Khomeini Hospital Complex in Tehran, Iran. […] Duration of intervention: 7 days from randomization Intervention in the treatment group: Vitamin A 25,000 IU daily Vitamin D 600,000 IU once during study Vitamin E 300 IU twice daily Vitamin C is taken four times per day B vitamins are taken as a daily Soluvit [which included thiamine nitrate 3.1 mg, sodium riboflavin phosphate 4.9 mg (corresponding to vitamin B2 3.6 mg), nicotinamide 40 mg, pyridoxine hydrochloride 4.9 mg (corresponding to vitamin B6 4.0 mg), sodium pantothenate 16.5 mg (corresponding to pantothenic acid 15 mg), sodium ascorbate 113 mg (corresponding to vitamin C 100 mg), biotin 60 μg, folic acid 400 μg, and cyanocobalamin 5 μg] The control group will not receive any supplements or placebo. […] All treatment staff will be aware of which group each of the patients is in due to the specific conditions of the ICU and the absence of placebo for the control group. | 2020-07-08 |
| 32631442 | Intensive clinical trials on the treatment of COVID-19 using traditional Chinese medicine and Western medicine are ongoing or will be performed in China. […] However, based on the uncertain methodological quality, small sample size, and long trial duration, we will not be able to obtain reliable, high-quality clinical evidence regarding the treatment of COVID-19 in the near future. | 2020-07-08 |
| 32631459 | However, many non-palliative care clinicians face deep uncertainty in planning, conducting, and evaluating such interactions. […] We believe that specialists within palliative care are aptly positioned to address such uncertainties, and in this article offer a relevant update to a concise framework for clinicians to plan, conduct, and evaluate goals-of-care conversations: the GOOD framework. […] Once familiar with this framework, palliative care clinicians may use it to educate their non-palliative care colleagues about a timely and critical component of care, now and beyond the COVID-19 era. | 2020-07-08 |
| 32631469 | Most of them are not eligible for intensive care treatment but can still expect palliative care - in many cases provided by a Hospital Palliative Care Team (HPCT). […] COVID-19 patients who are not eligible for ICU treatment may have a particularly high need for palliative care. […] Since beds in specialist palliative care units are limited, the HPCT should be prepared to care for these patients. | 2020-07-08 |
| 32631470 | Early isolation and treatment, stressing prevention of cluster outbreaks, could help prevent further spread of the epidemic. | 2020-07-08 |
| 32631666 | In this critical scenario, lung cancer patients scheduled for surgical treatment need to continue to receive optimal care while protecting them from an eventual severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. | 2020-07-08 |
| 32631736 | The patient who continued iguratimod therapy without dose reduction was treated with ciclesonide had an uneventful clinical course, but prolonged detection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was observed after resolution of symptoms. | 2020-07-08 |
| 32631771 | We recommend physicians remain vigilant for inflammatory syndromes that mimic KD/KDSS which may warrant prompt treatment with IVIG and steroids. | 2020-07-08 |
| 32631958 | Further studies of both the role of nasal receptors in cough pathophysiology and the role of fan therapy in cough, where there is no concern of an airborne infectious pathogen such as COVID-19, are warranted. | 2020-07-08 |
| 32632359 | During the current COVID-19 pandemic, a need for evaluation of already available drugs for treatment of the disease is crucial. […] Therefore, early treatment with anti-oxidants such as NAC during COVID-19 can be a way to bypass the excessive inflammation and cell damage that lead to severe infection, thus early NAC as intervention should be evaluated in a clinical trial setting. | 2020-07-08 |
| 32632417 | Supplemental oxygen therapy was required in 18 patients (56·3%), with high-flow requirements in six (18·7%). | 2020-07-08 |
| 32632558 | Consequently, in accordance with previous studies, our study outlines that anti-coagulation may constitute a promising tool for the treatment of SARS-CoV-2, reducing both, the cytokine storm, as well as the risk for thrombotic complications. | 2020-07-08 |
| 32632667 | ICU-treatment included mechanical ventilation and therapeutic anticoagulation. | 2020-07-08 |
| 32632717 | To seek potential Chinese herbal medicine (CHM) for the treatment of coronavirus disease 2019 (COVID-19) through the molecular docking of the medicine with SARS-CoV-2 3CL hydrolytic enzyme and the angiotensin converting enzyme II(ACE2) as receptors, using computer virtual screening technique, so as to provide a basis for combination forecasting. | 2020-07-08 |
| 32632766 | Many drugs have shown promise for treatment of COVID-19. […] Nevertheless, up to date, no drugs have been confirmed as a definitive treatment for COVID-19. […] Trials such as the SOLIDARITY and RECOVERY are ongoing, and first results were announced in favour of therapy with dexamethasone with a significant trend showing greatest benefit among those patients requiring ventilation. | 2020-07-08 |
| 32632825 | There have been significant advances in the diagnosis and treatment of cardiovascular disease; however, racial disparities continue to create inequity in the medical community especially for African Americans. […] Williams founded the Association of Black Cardiologists (ABC) in 1974 to address the misperception about, and the misdiagnosis and maltreatment of African American patients. […] He emphasized the importance of diversity and the non-biased approach to the treatment of all communities. | 2020-07-08 |
| 32632947 | We recorded detailed treatment and follow-up process, and collected relevant data. | 2020-07-08 |
| 32632960 | To date, no vaccines or effective therapeutics have been discovered yet that may successfully treat COVID-19 patients or contain the transmission of the virus. […] In this uncertainty, repurposing the existing antiviral drugs could be the best strategy to speed up the discovery of effective therapeutics against SARS-CoV-2. […] Progresses on the development of potential therapeutics and vaccines that are under the preclinical studies and clinical trials have been highlighted. […] We anticipate that this review will provide valuable information that would help to accelerate the development of therapeutics and vaccines against SARS-CoV-2 infection. | 2020-07-08 |
| 32633068 | Significant differences between subjects with and without DVT were D-dimer > 3000 µg/L (P < .05), current or previous cancer (P < .05), and need of high flow nasal oxygen therapy and/or non-invasive ventilation (P < .01). | 2020-07-08 |
| 32633162 | Since the patient refused admission to the hospital and had stable vital signs, we chose to treat him with a safe anti-inflammatory and non-immunosuppressive therapy. […] Unexpectedly, 48 hours after treatment, not only did his ongoing fever and toe pain disappear, he also had significant improvements in his general state of health and all his inflammatory markers including fibrinogen, ferritin, D-dimer, and IL-6 levels normalized. […] This observation merits the consideration of colchicine as a safe, inexpensive and oral medication for the treatment of mild to moderate CRS in Covid-19 patients. […] Indeed, multicenter, randomized controlled studies are required to evaluate the benefits of this therapy. | 2020-07-08 |
| 32633215 | Many centers have established prone ventilation in their treatment algorithm for mechanically ventilated patients with severe acute respiratory distress syndrome (ARDS). | 2020-07-08 |
| 32633235 | RAS inhibitors are currently widely used in the treatment of hypertension. […] While the SARS-CoV-2 viral load remains the highest in upper respiratory tract of COVID-19 patients, it has also been reported in multiple sites in COVID-19, and patients not infrequently require the Intensive Care Units (ICU) admission. | 2020-07-08 |
| 32633236 | COVID-19 impacts the therapy of patients with inflammatory bowel disease (IBD), particularly those using high doses of corticosteroids, immunosuppressive agents and biologics. | 2020-07-08 |
| 32633410 | However, the effective treatment for COVID-19 patients with bronchogram has not been discussed. […] These findings revealed that the body temperature and clinical laboratory test all returned to normal after this patient received a prolonged treatment. […] These results provide an important reference for treatment option of COVID-19 with bronchogram. | 2020-07-08 |
| 32633418 | This study aimed to investigate whether the use of oral antithrombotic therapy (OAT) was associated with a lower mortality in NH residents with COVID-19. […] Age, comorbidity, and medication use were comparable among NH residents who survived and who died. | 2020-07-08 |
| 32633464 | Strategies such as maintaining a healthy lifestyle and social contacts, acceptance of anxiety and negative emotions, fostering self-efficacy, and information on where to get medical treatment if needed, seem of help, while substance abuse and suppression of anxiety and negative emotions seem to be associated with more psychological burden. | 2020-07-08 |
| 32633594 | Thus, patients with hypertension undergoing angiotensin-converting enzyme inhibitor and/or angiotensin receptor blockers drug therapy may be at a higher risk of contracting a serious COVID-19 infection and should be monitored. […] Consequently, tailored anti-inflammatory and immune therapies in addition to chronic antihypertensive therapy, could prevent a worse prognosis, as well as improve the clinical outcomes in patients with hypertension with COVID-19 infection. | 2020-07-08 |
| 32633712 | Among patients, 52 (52%) were hospitalized, 10 (10%) in intensive care units (ICUs). | 2020-07-08 |
| 32633733 | If confirmed in vitro, our results provide a molecular rationale for the use of HCQ or of strictly related derivatives in the treatment of Covid-19. | 2020-07-08 |
| 32633860 | Young plasma infusions have emerged as a potential treatment for neurodegenerative disease, and convalescent plasma therapy has been used safely in the management of viral pandemics. […] However, the effect of plasma therapy in Parkinson’s disease (PD) is unknown. […] A total of 15 people with clinically established PD, at least 1 cognitive complaint, and on stable therapy received 1 unit of young fresh frozen plasma twice a week for 4 weeks. […] Assessments and adverse effects were performed/reported on and off therapy at baseline, immediately after, and 4 weeks after the infusions ended. […] Exploratory outcomes included Unified Parkinson’s Disease Rating Scale Part III off medication, neuropsychological battery, Parkinson’s Disease Questionnaire-39, inflammatory markers (tumor necrosis factor-α, interleukin-6), uric acid, and quantitative kinematics. […] The results of this study warrant further therapeutic investigations in PD and provide safety and feasibility data for plasma therapy in people with PD who may be at higher risk for severe complications of COVID-19. | 2020-07-08 |
| 32633997 | To date, there is no recommended medical treatment, and supportive measures are a crucial part of management. | 2020-07-08 |
| 32634004 | Other measures include incorporating family-focused behavioural interventions in their practice, home-based care to reduce the number of persons visiting the hospital, telemedicine and Hospice and palliative care services to the elderly and terminally ill. […] In conclusion, FPs in Nigeria are helping to reduce the scourge of COVID-19 through patient education and innovative healthcare delivery that does not put patients at increased risk of the disease whilst promptly recognising potential COVID-19 patients and referring them for early diagnosis and treatment. | 2020-07-08 |
| 32634005 | As the Coronavirus disease 2019 (COVID-19) pandemic has spread globally, with no effective treatment or vaccine yet available, governments in many countries have put in place social interventions to control the outbreak. | 2020-07-08 |
| 32634023 | This multicentre cohort study included 340 COVID-19-negative patients versus 82 COVID-19-positive patients undergoing surgical treatment for hip fractures across nine NHS hospitals in Greater London, UK. […] Patients in both treatment groups were comparable for age, sex, body mass index, fracture configuration, and type of surgery performed. | 2020-07-08 |
| 32634024 | More than ever, valid, transparent, and intuitive summaries of the treatment effects, including efficacy and harm, are needed. […] Moreover, almost all trials have quantified treatment effects by using the hazard ratio, which is difficult to interpret for a positive event, especially in the presence of competing risks. […] Furthermore, an intuitive and clinically interpretable summary of treatment efficacy based on this curve is also proposed. […] Clinical investigators are encouraged to consider applying these methods for quantifying treatment effects in future studies of COVID-19. | 2020-07-08 |
| 32634079 | Currently, they are used as monotherapy or in conjunction with other therapies for the treatment of autoimmune diseases such as systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), Sjögren’s syndrome (SS) and antiphospholipid antibody syndrome (APS). […] Based on its effects on the modulation of the autophagy process, various clinical studies suggest that CQ and HCQ could be used in combination with other chemotherapeutics for the treatment of various types of cancer. […] Food and Drug Administration (FDA) for the treatment of infected patients with the coronavirus SARSCoV- 2, causing the disease originated in December 2019, namely COVID-2019. | 2020-07-08 |
| 32634080 | No specific treatment for COVID-19 is currently available. […] Usual palliative treatment includes maintaining hydration and nutrition and controlling fever and cough. […] The present review discusses the recent repurposing of drugs for COVID-19 treatment. […] Although some evidence indicates the positive actions of different classes of compounds for the treatment of COVID-19, few clinical assays have been established to definitively demonstrate their therapeutic value in humans. | 2020-07-08 |
| 32634106 | Patients who receive treatment at concussion specialty clinics, versus primary care, experience faster recovery, thereby reducing patient burden and subsequent medical-related costs. […] However, a model of telehealth delivered concussion assessment, treatment, and management has not been established. […] This is the first paper to provide a clinically relevant framework for the assessment, management, and treatment of acute concussion via telehealth in a pediatric population. | 2020-07-08 |
| 32634126 | These observations provide important information on the serological response to SARS-CoV-2 of hospitalized patients with COVID-19 that can inform the use of convalescent plasma therapy. | 2020-07-08 |
| 32634129 | Two groups of patients with RT-PCR-confirmed COVID-19 were enrolled in this study: 12 severely ill patients in intensive care units who needed mechanical ventilation and 11 mildly ill patients in isolation wards. | 2020-07-08 |
| 32634438 | There are no known treatment regimens with proven efficacy and vaccines thus far, posing an unprecedented challenge to identify effective drugs and vaccines for prevention and treatment. […] The urgency for its prevention and cure has resulted in an increased number of proposed treatment options. […] This review describes the proposed drug targets for therapy, and outcomes of clinical trials that have been reported. […] It also identifies the adopted treatment modalities that are showing promise, and those that have failed as drug candidates. […] It further highlights various emerging therapies and future strategies for the treatment of COVID-19 and delivery of Anti-SARS-CoV2 drugs. | 2020-07-08 |
| 32634459 | The aim is to provide new strategies for COVID-19 prevention and treatment. | 2020-07-08 |
| 32634550 | The lack of specific treatment and gold-standard diagnostic system has made the situation more complicated. […] On the other hand, some of already-introduced aptamers have shown the inhibitory effects on coronavirus that could be applied as therapeutics. | 2020-07-08 |
| 32634585 | Dynamic monitoring of human immune function is one of the indicators for evaluating the severity of disease and the prognosis of COVID-19 patients, and is useful for formulating appropriate treatment strategies. | 2020-07-08 |
| 32634589 | Convalescent plasma (CP) has been used successfully to treat many types of infectious disease, and has shown initial effects in the treatment of the emerging 2019 coronavirus disease (COVID-19). […] To explore the effectiveness of treatment and predict the potential effects of CP with COVID-19, studies of different types of infectious disease treated with CP were included in this systematic review and meta-analysis. […] The data quality was assessed, and the data were extracted and pooled for analysis. 40 studies on CP treatment for infectious diseases were included. […] Our study found that CP treatment could reduce the risk of mortality, with a low incidence of adverse events, promote the production of antibodies, lead to a decline in viral load, and shorten the disease course. […] CP therapy has some curative effect and is well tolerated in treating infectious diseases. […] It is a potentially effective treatment for COVID-19. | 2020-07-08 |
| 32634602 | The aim of this study was to evaluate the impact of addition of corticosteroids to the hospital protocol for treatment of suspected or confirmed COVID-19 pneumonia on rates of death or intensive care unit (ICU) admission. […] A before-after study was performed to evaluate the effect of addition of corticosteroids to our institution’s COVID-19 treatment protocol on hospital mortality. […] In conclusion, addition of corticosteroids to our institution’s COVID-19 treatment protocol was associated with a significant reduction in hospital mortality in the ‘after’ period. | 2020-07-08 |
| 32634603 | Currently, there is no approved therapy for coronavirus disease 2019 (COVID-19). […] However, frontline clinicians and researchers have been experimenting with several virus-based and host-based therapeutics since the outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in China. […] China’s National Health Commission has issued the first COVID-19 treatment guidelines with therapy suggestions, which has inspired clinical studies worldwide. […] This review evaluates the major therapeutics. […] Ribavirin may be beneficial as an add-on therapy but is ineffective as monotherapy. | 2020-07-08 |
| 32634717 | This technology has the potential to improve the drug discovery, planning, treatment, and reported outcomes of the COVID-19 patient, being an evidence-based medical tool. | 2020-07-08 |
| 32634734 | The current SARS-Cov-2 virus pandemic challenges critical care physicians and other caregivers to find effective treatment for desperately ill patients - especially those with sudden and extreme hypoxemia. | 2020-07-08 |
| 32634830 | Significantly fewer female patients received antibiotics treatment (p=0.001), antiviral therapy (p=0.025) glucocorticoids treatment (p<0.0001), mechanical ventilation (p<0.0001) and had Intensive Care Unit admission (p<0.0001). | 2020-07-08 |
| 32635188 | In fact, patients at higher risk of neurological involvement may need different monitoring and treatment strategies in order to prevent severe, permanent brain injury. | 2020-07-09 |
| 32635302 | Severity of infection varies from complete absence of symptomatology to more aggressive symptoms, characterized by sudden acute respiratory distress syndrome (ARDS), multiorgan failure, and sepsis, requiring treatment in intensive care unit (ICU). | 2020-07-09 |
| 32635353 | The treatment was well-tolerated in conjunction with standard drug therapies for COVID-19 (hydroxychloroquine, azithromycin, and zinc). […] Conclusion: The early, proactive identification of serum acute phase reactants should be implemented in the treatment of COVID-19 in order to screen for a primary contributor to mortality-the cytokine storm. […] This screening, when followed by aggressive early treatment for cytokine storm, may have optimal therapeutic benefits and obviate the need for mechanical ventilation, thereby decreasing mortality. […] Additionally, we review current evidence regarding cytokine release syndrome in COVID-19 and the use of IL-6 receptor inhibition as a therapeutic strategy, and examine other reported cases in the literature describing IL-6 antagonist treatment for patients with COVID-19. | 2020-07-09 |
| 32635422 | Overall, the total number of patients treated did not differ during COVID-19 from the months before (p = 0.133) and psychotherapy in personal contact remained the most common treatment modality. | 2020-07-09 |
| 32635444 | In the absence of vaccines and effective therapeutics, reliable serological testing must be a key element of public health policy to control further spread of the disease and gradually remove quarantine measures. | 2020-07-09 |
| 32635598 | In turn, the maneuverability margins of such hijacking appear to be so narrow that the modulation of the autophagy, regardless of whether using inducers or inhibitors (many of which are FDA-approved for the treatment of other diseases), is usually detrimental to viral replication, including SARS-CoV-2. […] Thus, the combinatory treatment of COVID-19 with drugs affecting both canonical and noncanonical autophagy pathways may be a turning point in the fight against this and other viral infections, which may also imply beneficial prospects of long-term protection. | 2020-07-09 |
| 32635752 | Understanding this molecular mechanism of ILs, T cells, and dendritic cells will be helpful to design immunotherapy and novel drugs for the treatment of nCOVID-19 infection. | 2020-07-09 |
| 32635912 | This strategy would require deliberate exposure of volunteers to SARSCoV2 with no currently available treatment and a small but definite risk of serious illness or death. | 2020-07-09 |
| 32635960 | It is imperative to consider how the rising proportion of XDR-TB is best tackled during the pandemic; this includes finding a solution to the problem of non-adherence at the level of community-based healthcare, the utility and practicality of simultaneous testing for COVID-19 and TB, and reconciliation of the World Health Organization’s recommendation of home-based treatment with the need for frequent monitoring of anti-tubercular therapy in XDR-TB. | 2020-07-09 |
| 32636061 | Aggressive treatment should be suggested, especially when these patients had low CD4+T lymphocyte counts and high SAA levels. | 2020-07-09 |
| 32636114 | Even though there are clinical trials on the development of therapeutics and vaccines, there are currently no licensed vaccines or therapeutics for COVID-19. […] Extracorporeal blood purification could be proposed as an adjunctive therapy for sepsis, aiming to control the associated dysregulation of the immune system, which is known to protect organ functions. […] For this purpose, plasmapheresis and immunoadsorption may be an important adjunctive treatment option to manage the complications caused by cytokine storm in critically ill patients with COVID-19. | 2020-07-09 |
| 32636116 | At the beginning of the disease, we used antiviral drugs and immune modulators as therapy but without any positive results. […] We did not observe any adverse events of this treatment. […] The girl still has a diagnosis of aplastic anemia and requires specialist therapy. | 2020-07-09 |
| 32636240 | BCG remains the standard immunotherapy treatment for patients with high-risk non-muscle invasive bladder cancer globally for more than 44 years. […] We propose that lessons learned from BCG immunotherapy success could be applied to not only augment such microbe-based therapeutics but also lead to similar adjunctive IFN-1 activating approaches to improve response to immune checkpoint blockade therapy in cancer. | 2020-07-09 |
| 32636454 | The non-human primate model that we established here provides a valuable platform to study SARS-CoV-2 pathogenesis and to evaluate candidate vaccines and therapeutics. | 2020-07-09 |
| 32636542 | Diagnostic tests for the coronavirus infection 2019 (COVID-19) are critical for prompt diagnosis, treatment and isolation to break the cycle of transmission. […] Serology is gaining attention, mainly because of convalescent plasma gaining importance as treatment for clinically worsening COVID-19 patients. | 2020-07-09 |
| 32636686 | The aim of this review was to describe the current knowledge about coronavirus disease 2019 (COVID-19, which is caused by severe acute respiratory syndrome coronavirus 2 [SARS-CoV-2]) in children, from epidemiological, clinical, and laboratory perspectives, including knowledge on the disease course, treatment, and prognosis. […] The recommended treatment includes providing symptomatic therapy, with no specific drug recommendations for children. […] This review highlights that COVID-19 in children is similar to the disease in the adult population, but with particularities regarding clinical manifestations, laboratory test results, chest imaging, and treatment. | 2020-07-09 |
| 32636851 | It is imperative to study and develop pharmacological treatments suitable for the prevention and treatment of COVID-19. […] We present the current evidence for the use of vitamin C and quercetin both for prophylaxis in high-risk populations and for the treatment of COVID-19 patients as an adjunct to promising pharmacological agents such as Remdesivir or convalescent plasma. | 2020-07-09 |
| 32636919 | While certain medications initially garnered attention as potential treatment options, further studies failed to demonstrate great promise but did demonstrate the need to reduce the cytokine storm experienced by patients with this potentially life-threatening virus. […] Unfortunately, there is no cure on the horizon, but members of the medical community are beginning to evaluate the potential role of vitamins and supplements as potential treatment options or addition to other treatments. […] The goal of this narrative review is to evaluate current and ongoing clinical trials of vitamins and supplements, alone or in combination with each other or other therapies, for the treatment of coronavirus disease-2019 (COVID-19). | 2020-07-09 |
| 32637086 | Two male cases (a 46-year-old and a 56-year-old) after being diagnosed with severe COVID-19, they deteriorated despite supportive care and antiviral therapy. […] CP might be an effective therapy for severe COVID-19 patients. | 2020-07-09 |
| 32637266 | However, the evidence regarding the association of mental health illnesses and psychiatric treatment on the prognoses of COVID-19 is still lacking. […] Lithium is a commonly prescribed psychiatric medication that is also well known for its highly lethal toxicity. | 2020-07-09 |
| 32637278 | Currently, there is limited evidence available in this area and further research may help in developing effective treatment strategies. | 2020-07-09 |
| 32637293 | In the United States, applied behavior analysis (ABA) is broadly recognized as a medically necessary treatment for individuals diagnosed with autism and related disorders (Association of Professional Behavior Analysts, 2020, Guidelines for practicing applied behavior analysis during COVID-19 pandemic, Retrieved from https://cdn.ymaws.com/www.apbahome.net/resource/collection/1FDDBDD2-5CAF-4B2A-AB3F-DAE5E72111BF/APBA_Guidelines_-_Practicing_During_COVID-19_Pandemic_040920.pdf). […] We argue that this designation should not be called into question in light of a particular disaster and that it is critical to consider that an interruption of services can have long-lasting effects on the treatment of the individual (practitioners are ethically obligated to uphold the continuity of services while doing no harm). | 2020-07-09 |
| 32637987 | Further clinical, neuroradiological, biomarker and neuropathological studies are essential to determine the underlying pathobiological mechanisms, which will guide treatment. | 2020-07-09 |
| 32638107 | To report the understanding and decision-making of neuroimmunologists and their treatment of patients with multiple sclerosis (MS) during the early stages of the SARS-CoV-2 (COVID-19) outbreak. | 2020-07-09 |
| 32638507 | Moreover, the impact of treatment with antihyperglycemic drugs and glucocorticoids is unclear. […] In severe COVID-19 patients with T2DM, we demonstrated a higher risk of all-cause fatality with glucocorticoid treatment (adjusted hazard ratio [HR], 3.61; 95% CI, 1.14-11.46; P = .029) and severe hyperglycemia (fasting plasma glucose ≥11.1 mmol/L; adjusted HR, 11.86; 95% CI, 1.21-116.44; P = .034). […] Poor fasting blood glucose (≥ 11.1 mmol/L) and glucocorticoid treatment are associated with poor prognosis for T2DM patients with severe COVID-19. | 2020-07-09 |
| 32638509 | A thorough understanding of how coronaviruses interact with RNA-related posttranscriptional processes in the cell should allow for new insights into aspects of viral pathogenesis as well as identify new potential avenues for the development of anti-coronaviral therapeutics. | 2020-07-09 |
| 32638559 | For allergic patients who have been followed up at an allergy clinic in our region, it is recommended that they (patients with asthma, rhinitis, atopic dermatitis or chronic urticaria) continue to receive maintenance therapy and be in a well-controlled status. […] Patients who have used biologics (currently available for targeting type 2 inflammation) and allergen immunotherapy should continue the treatment while minimizing hospital and face-to-face visits. | 2020-07-09 |
| 32638632 | Patients were divided into 2 groups, those with a palliative care consult (palliative group: 14.2% [n = 32]) versus those with no palliative care consult (no palliative group: 85.8% [n = 193]). […] Patients with palliative care had higher rates of invasive mechanical ventilation than those without (46.9% vs 10.4%, P < .001). […] The rate of full code decreased by 70% in the palliative group and by 47.5% in the no palliative care group from admission to the time of death. | 2020-07-09 |
| 32638647 | There is no agreed treatment for cytokine storm. […] Three therapeutic agents with proven immune-modulatory properties in regular use in a wide range of inflammatory disorders (high dose intravenous immunoglobulin, Rituximab and thalidomide) are proposed for the treatment of cytokine storm. […] Safety and efficacy of the proposed treatment should be assessed by randomised controlled clinical trials. […] The use of the proposed treatment is expected to reduce the mortality rate and alter the overall management of the pandemic. | 2020-07-09 |
| 32638909 | As malignant tumors of the head and neck are clinically time sensitive, neither consultations for these tumors nor their treatment should be postponed. […] Postponing surgical treatment can result in a change in the disease stage and alter an individual’s chance of survival. […] The treatment of other chronic diseases, such as cancer, should be continued, as the damming of cases of these diseases will have a deleterious effect on the public healthcare system. | 2020-07-09 |
| 32638911 | In this regard, there were several doubts on how to approach these cases, among them: how to quickly identify the patient with COVID-19, what is the impact of the abdominal surgical disease and its treatment on the evolution of patients with COVID-19, in addition to the discussion about the role of the non-operative treatment for abdominal disease under these circumstances. | 2020-07-09 |
| 32638914 | Priority consensus: 1- Construction of service priorities; 2 - Interdisciplinary discussion on minimally invasive or conventional pathways. the Brazilian Society of Surgical Oncology (BSSO) suggests a script for coping with oncological treatment, remembering that the impoundment in the assistance of these cases, can configure a new wave of overload in health systems. | 2020-07-09 |
| 32638937 | Treatment algorithms have changed in general surgery clinics, as in other medical disciplines providing emergency services, with greater changes seen especially in pandemic hospitals. | 2020-07-09 |
| 32638938 | The population for this descriptive study comprised clinicians working in a variety of healthcare organizations in Turkey who provide monitoring and treatment within the intensive care process for COVID-19 patients. […] Among all the participants, 54.8% stated that they were undecided about corticosteroid treatment for patients who had been intubated due to COVID-19. […] Many medications and methods are used for COVID-19 treatment. […] All national science committees are attempting to create standard treatment protocols. […] For intensive care treatment of COVID-19 patients, many factors require management, and clinicians’ experience is guiding future processes. […] We believe that this study will create awareness about this topic and contribute to the creation of standard treatment algorithms and the provision of better and safer healthcare services for this patient group. | 2020-07-09 |
| 32639031 | Vorapaxar is an approved inhibitor of PAR1, used for treatment of patients with myocardial infarction or peripheral arterial disease. […] We discuss evidence for a possible beneficial role for vorapaxar in the treatment of COVID-19 patients and other as-yet non-approved antagonists of PAR1 and proteinase-activated receptor 4 (PAR4). | 2020-07-09 |
| 32639051 | This review summarizes research on behavioral strategies to address handwashing in children, offers areas for additional research, and suggests a treatment package to teach handwashing to young children. | 2020-07-09 |
| 32639062 | Given its approval for the treatment of cytokine release syndrome, tocilizumab is under investigation in severe coronavirus disease-2019. | 2020-07-09 |
| 32639077 | During pandemic, Non-infected non-at risk patients with immune-medicated dermatologic disorders under treatment with immunosuppressive immunomodulators do not need to alter their regimen or discontinue their therapies. | 2020-07-09 |
| 32639183 | In addition, the clinical uses of these molecules are explored, such as in the treatment of inflammatory conditions including sepsis and Kawasaki disease, which has recently been associated with severe acute respiratory syndrome coronavirus 2 infection in children. | 2020-07-09 |
| 32639233 | Hydroxychloroquine and chloroquine are used extensively in malaria and rheumatological conditions, and now in COVID-19 prevention and treatment. | 2020-07-09 |
| 32639615 | Timely head and neck cancer (HNC) treatment must be prioritized, even during emergencies. | 2020-07-09 |
| 32639679 | Brain MRI raised evidence that Covid-19 or its related treatment may involve the brain with an unusual pattern of microbleeds, predominantly affecting the corpus callosum. | 2020-07-09 |
| 32639711 | Along with this, a challenge has been raised for research professionals to find effective drugs for its treatment since the recent spread of this virus from Wuhan, China. […] Targeting the treatment of brain infection, it has also been a challenge that the clinical drug should have good CNS penetration ability to cross the blood-brain barrier. | 2020-07-09 |
| 32639742 | With the current COVID-19 outbreak, it has become essential to develop efficient methods for the treatment and detection of this virus. | 2020-07-09 |
| 32639848 | Thus, treatment options for COVID-19 patients should be promptly adjusted when they have gastrointestinal symptoms. | 2020-07-09 |
| 32639860 | Anecdotal evidence suggests that the coronavirus disease 2019 (COVID-19) pandemic mitigation efforts may inadvertently discourage patients from seeking treatment for stroke with resultant increased morbidity and mortality. […] Reperfusion treatment rates, particularly thrombolysis, also appeared to decline qualitatively, and this finding requires further study. | 2020-07-09 |
| 32639862 | Triage urgency was determined based on clinical assessment of urgency with which a patient would require medical treatment or surgical intervention. | 2020-07-09 |
| 32639877 | Face-to-face appointments remained for patients who needed urgent start of therapy or performance status assessment. | 2020-07-09 |
| 32640172 | In recent years, several ultrapotent PARP inhibitors have been approved for clinical use (for the therapy of various oncological diseases): these newly-approved PARP inhibitors were recently reported to show efficacy in animal models of ALI. […] In addition, the article also overviews the scientific basis of potentially applying PARP inhibitors for the experimental therapy of viral ALI, such as COVID-19-associated ARDS. | 2020-07-09 |
| 32640179 | Here, we provide a general overview of what is currently known about the structure and characteristic features of SARS-CoV-2, some of which could potentially be exploited for the purposes of antiviral therapy and vaccine development. […] This minireview also covers selected and noteworthy antiviral agents/supportive therapy out of hundreds of drugs that are being repurposed or tested as potential treatments for COVID-19, the disease caused by SARS-CoV-2. | 2020-07-09 |
| 32640331 | Prevention and treatment of non-communicable diseases (NCDs), including cardiovascular disease, diabetes, obesity, cancer, Alzheimer’s and Parkinson’s disease, arthritis, non-alcoholic fatty liver disease and various infectious diseases; lately most notably COVID-19 have been in the front line of research worldwide. | 2020-07-09 |
| 32640487 | Clinical trials with BTK inhibitors in COVID-19 treatment have been proposed, and previous studies have attempted to investigate the therapeutic effects of ibrutinib and underlying mechanisms in treating viral pneumonia. […] These attempts, however, did not consider potential off target effect of BTK inhibitors on T cell differentiation, function, and survival, which may be beneficial in treatment for COVID-19. […] Here, we summarize the current knowledge of BTK/IL-2-inducible T-cell kinase (ITK) signaling in immunopathology and lymphopenia and discuss the potential of BTK/ITK dual inhibitors such as ibrutinib in modulating immunopathology and lymphopenia, for COVID-19 therapy. | 2020-07-09 |
| 32640747 | Furthermore, we discuss how immune modifying drugs, such as tocilizumab, chloroquine, glucocorticoids and immunoglobulins, and blood purification therapy, can constitute a fundamental moment in the therapy of the infection. | 2020-07-10 |
| 32640852 | Clinicians should also consider integrating new technologies such as virtual reality (VR) in the treatment of these trauma and stress-related psychopathological symptoms. | 2020-07-10 |
| 32640936 | The patient failed to respond to initial treatment with intravenous immunoglobulin, high-dose steroids, and platelet transfusion, but responded to eltrombopag, with prompt improvement of a platelet count. | 2020-07-10 |
| 32641013 | By sharing the clinical characteristics, treatments and outcomes of 18 patients with COVID-19 during late pregnancy, we hope to provide some references for obstetric treatment and management. […] The majority of patients in late term pregnancy with COVID-19 were of ordinary type, and they were less likely to develop into critical pneumonia after early isolation and antiviral treatment. | 2020-07-10 |
| 32641059 | So far, there is no effective therapy and vaccine available against this novel virus and therefore, only supportive care is used as the mainstay of management of patients with COVID-19. […] This work aimed to provide insight on the newly emerged COVID-19, in the hope to gain a better understanding on the general overview, epidemiology, transmission, clinical features, diagnosis, treatment, and clinical outcomes as well as the prevention and control of COVID-19. | 2020-07-10 |
| 32641091 | The outbreak of COVID-19 (caused by SARS-Cov-2) is very serious, and no effective antiviral treatment has yet been confirmed. […] We found that the lopinavir/ritonavir treatment recommended in the fifth edition of the Treatment Plan of China can only help to improve a minority of throat-swab nucleic-acid results (3/15) in hospitals. […] The study consists of three phases: a screening period, a treatment period of no more than 10 days, and a follow-up period for each participant. […] The control group will be given lopinavir/ritonavir treatment for no more than 10 days. […] The trial group will be given chloroquine phosphate treatment for no more than 10 days. […] The primary outcome is the clinical recovery time at no more than 28 days after the completion of therapy and follow-up. […] The secondary outcomes include the rate of treatment success after the completion of therapy and follow-up, the time of treatment success after no more than 28 days, the rate of serious adverse events during the completion of therapy and follow-up, and the time to return to normal temperature (calculated from the onset of illness) during the completion of therapy and follow-up. […] If the new treatment including chloroquine shows a higher rate of throat-swab SARS-CoV-2 real-time fluorescent reverse transcription polymerase chain reaction (RT-PCR) negativity and is safe, it could be tested as a future COVID-19 treatment. | 2020-07-10 |
| 32641121 | The aim of our study is to summarize the characteristics of different subtypes and explore risk factors of illness severity for early identification and prompt treatment. | 2020-07-10 |
| 32641133 | The treatment of the data will be completed through Thematic Analysis and discussed in light of the Health Psychology framework, with the production of categories that answer the proposed research questions. | 2020-07-10 |
| 32641154 | Eligible patients will be randomised using a central web-based randomisation service (Sealed Envelope) in a 1:1:1 ratio, stratified by site to one of the treatment arms or SoC. | 2020-07-10 |
| 32641163 | Exclusion criteria include duration symptoms of febrile disease for ≥ 1 week, treatment limitations in place or moribund patients, allergy or intolerance of any study treatment, and pregnancy. […] Therefore, patients most likely to benefit from the treatment are those with severe but early disease. […] This trial is designed and powered to investigate whether the treatment in this cohort of patients leads to improved clinical patient-centred outcomes, such as mechanical ventilation-free survival. | 2020-07-10 |
| 32641169 | The symptoms were relieved 6 days after treatment. […] In this case report, the pathogenesis, clinical manifestations, treatment, and outcome of a case with COVID-19 complicated by relapsing viral keratoconjunctivitis is described, and the involvement of topical cytokine surge in the pathogenesis of COVID-19 as it relates to viral keratoconjunctivitis is reported. | 2020-07-10 |
| 32641292 | Local authorities and employers must act quickly to stop the spread, ensure easy access to testing and treatment, provide adequate housing and clear communication, encourage wide social support, safeguard financial protection and mental well-being and continuously re-evaluate the situation as more data are collected. | 2020-07-10 |
| 32641296 | The median durations from symptom onset to hospitalization and treatment initiation were 7 days (interquartile range [IQR], 4 to 10) and 8 days (IQR, 5 to 10), respectively. […] The median LPV trough concentration on day 3 of treatment was 26.5 μg/ml (IQR, 18.9 to 31.5). | 2020-07-10 |
| 32641312 | However, during the surgical phase of treatment, the COVID-19 or SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) outbreak occurred changing the healthcare landscape due to uncertainty regarding the virus, risk of COVID-19 infection and complications, and implementation of an enhanced community quarantine restricting movement of people within cities. […] Multidisciplinary sarcoma team meetings with family members and a sarcoma navigator nurse were crucial in managing expectations and deciding on appropriate treatment in the setting of a novel infectious disease causing a pandemic. | 2020-07-10 |
| 32641343 | To date, symptomatic supportive care has been the most common treatment. […] Therefore, we hypothesise that HIVC could be added to the treatment of ARDS and multiorgan dysfunction related to COVID-19. | 2020-07-10 |
| 32641394 | We retrospectively analyzed the records of patients who were referred between March 2020 and May 2020 for primary surgical treatment of breast, endometrial, ovarian, cervical, or vulvar cancer. | 2020-07-10 |
| 32641446 | During the COVID-19 epidemic, the treatment of critically ill patients has been increasingly difficult and challenging. | 2020-07-10 |
| 32641482 | Interestingly, overexpression of serine protease TMPRSS2 or amphotericin treatment significantly neutralized the IFN-inducible transmembrane 3 (IFITM3) restriction of human coronavirus (CoV) entry, but did not compromise the effect of LY6E on the entry of human coronaviruses. | 2020-07-10 |
| 32641525 | Significant improvement in the parkinsonian symptoms was observed without any specific treatment. | 2020-07-10 |
| 32641644 | The National and International health agencies, including the National Institutes of Health (NIH), the Centers for Disease Control and Prevention (CDC), and the WHO have provided clear guidelines for both preventive and treatment suggestions. | 2020-07-10 |
| 32641700 | Thus, aberrant activation and dysregulation of CD8+ T cells occur in patients with severe COVID-19 disease, an effect that might be for pathogenesis of SARS-CoV-2 infection and indicate that immune-based targets for therapeutic interventions constitute a promising treatment for severe COVID-19 patients. | 2020-07-10 |
| 32641860 | We also give special consideration to immunosuppressive treatment and cell-depleting therapies that might increase susceptibility to SARS-CoV-2 infection but reduce the risk of severe COVID-19. | 2020-07-10 |
| 32641867 | These service constraints, coupled with concerns relating to an increased incidence and severity of COVID-19 among patients with cancer, should lead to re-consideration of the risk-benefit balance for standard treatment pathways. […] This is of particular importance to pancreatic cancer, given that standard diagnostic modalities such as endoscopy may be restricted, and that disease biology precludes significant delays in treatment. […] The outcomes are described here and include recommendations for treatment prioritisation, strategies to bridge to later surgical resection in resectable disease and factors that modify the risk-benefit balance for treatment in the resectable through to the metastatic settings. […] Priority is given to strategies that limit hospital visits, including through the use of hypofractionated precision radiotherapy and chemoradiotherapy treatment approaches. | 2020-07-10 |
| 32641873 | In the absence of an absolute cure, it is essential to explore the molecular pathogenesis of the disease to identify people at risk of developing severity so that alternative treatment modalities may be planned. | 2020-07-10 |
| 32641874 | Right at the center of the debate is the use of drug “Hydroxychloroquine” as a prophylaxis as well as a treatment strategy against Covid-19 in conjunction with azithromycin. | 2020-07-10 |
| 32641875 | As a novel viral disease there in no antiviral treatment or vaccine for the COVID-19. […] Currently the nucleic acid based polymerase chain reaction is used as the reliable diagnostic platform and antigen/antibody detection immunoassays are playing the role of screening tests for early detection and prognosis in COVID-19 treatment. | 2020-07-10 |
| 32641902 | Unfortunately, there is no available treatment for COVID-19, and there is no available vaccine against SARS-CoV-2. | 2020-07-10 |
| 32641984 | Quantitative nucleic acid testing has become the gold standard for diagnosis and guiding clinical decisions regarding the use of antiviral therapy. […] This brief review will be useful for the accurate diagnosis and timely treatment of the new coronavirus pneumonia. | 2020-07-10 |
| 32642005 | While our current understanding of COVID-19 pathogenesis is limited, a better understanding will help us develop efficacious treatment and prevention strategies for COVID-19. […] Importantly, targeting ACE2/Ang 1-7 axis and blocking ACE2 interaction with the S protein of SARS-CoV-2 to curtail SARS-CoV-2 infection are becoming very attractive therapeutics potential for treatment and prevention of COVID-19. […] Here, we will discuss the following subtopics: 1) ACE2 as a receptor of SARS-CoV-2; 2) clinical and pathological features of COVID-19; 3) role of ACE2 in the infection and pathogenesis of SARS; 4) potential pathogenic role of ACE2 in COVID-19; 5) animal models for pathological studies and therapeutics; and 6) therapeutics development for COVID-19. | 2020-07-10 |
| 32642345 | Gaining a better insight into the pathophysiology of renal failure will hopefully help develop more directed treatment options. […] Renal replacement therapy is used for a long time in critically ill septic patients who develop progressive renal failure despite adequate conservative support. […] Timing and choice of renal replacement therapy in critically ill COVID-19 patients remains an area of future research that may help decrease mortality in this patient population. | 2020-07-10 |
| 32642390 | Rapid identification and treatment with aggressive intravenous hydration and correction of electrolyte abnormalities remain key to successful management. […] In a pandemic, often atypical presentations of this new disease have to be considered as differentials for early diagnosis and treatment of life-threatening conditions. | 2020-07-10 |
| 32642770 | The present analysis implies that SARS-CoV-2 could affect multi-targets in diverse host tissues, and the treatment of COVID-19 would be a complex task. | 2020-07-10 |
| 32642806 | A patient with COVID-19-related severe respiratory failure, with insufficient response to an antiretroviral therapy, hydroxychloroquine and Interleukin-6 (IL-6) antagonist therapy, presented a prompt resolution of the respiratory function and improvement in the radiological picture after baricitinib at an oral dose of 4 mg per day for 2 weeks. | 2020-07-10 |
| 32642842 | To date, no vaccines are available nor any specific treatment. | 2020-07-10 |
| 32643004 | Endocrine treatment modifications as a consequence of COVID-19 infection are required in a proactive manner, in order to avoid decompensation and eventual hospital admission. | 2020-07-10 |
| 32643017 | As COVID-19 is spreading all over the world, we are in a desperate situation to find treatment solutions; however, despite the urgency, scientific rules have to be applied as bad science is unethical since it might be harmful for patients. | 2020-07-10 |
| 32643158 | Since no specific therapy is currently available for the same, the present study was aimed to explore the SARS-CoV-2 genome for the identification of immunogenic regions using immunoinformatics approach. | 2020-07-10 |
| 32643200 | There are currently no licensed vaccines or therapeutics for COVID-19. […] CP may be an adjunctive treatment option to the anti-viral therapy. […] Even though limited published studies are not prospective or randomized, until the development of vaccines or therapeutics, CP seems to be a safe and probably effective treatment for critically ill patients with COVID-19. | 2020-07-10 |
| 32643418 | The pooled incidence over follow-up of 2-28 days was 12.5% (10.1-15.0) for electrolyte disturbance (e.g. hyperkalaemia), 11.0% (7.4-15.1) for acute kidney injury (AKI) and 6.8% (1.0-17.0) for renal replacement therapy (RRT). | 2020-07-10 |
| 32643436 | Immunomodulatory molecules such as sarilumab, tocilizumab, janus kinase inhibitors, and hyperimmune convalescent plasma have mixed outcomes from initial clinical findings; however, pending randomised controlled trials will assist national health institutions to make treatment recommendations for COVID-19. […] This review discusses pharmacological interventions at play and evidence-based successes and limitations of non-pharmacological therapies such as social distancing, personal protective equipment, and ventilator support associated with the prevention and treatment of COVID-19. | 2020-07-10 |
| 32643489 | Lymphopenia, leukopenia, thrombocytopenia, disseminated intravascular coagulation, and a prothrombotic state are common manifestations of COVID-19 and have important treatment and prognostic implications. | 2020-07-10 |
| 32643550 | Inhalation of nitric oxide is used in the treatment of severe acute respiratory syndrome. | 2020-07-10 |
| 32643551 | Extracorporeal membrane oxygenation is a standard tool for the management of life-threatening acute respiratory distress syndrome, but the use of this resource-intensive therapy has come into question due to strained medical systems and limited proven treatments for COVID-19. | 2020-07-10 |
| 32643552 | Lack of targeted therapeutics and vaccines for COVID-2019 have triggered the scientific community to develop new vaccines or drugs against this novel virus. | 2020-07-10 |
| 32643596 | Although the genome of this novel viral RNA was sequenced quickly and testing kits were manufactured to assist in combatting COVID-19, the diagnosis and treatment will remain relatively unsuccessful until the pathology of this disease is fully understood. | 2020-07-10 |
| 32643603 | It is critical that vaccines and therapeutics be developed very rapidly. | 2020-07-10 |
| 32643811 | These studies targeted functional assessment and function-based treatment for challenging behavior. […] We briefly summarize what is known relative to the assessment and treatment of challenging behavior via telehealth, place these results within a descriptive context of the decisions made by the research team at the University of Iowa, and discuss what we, as behavior analysts, should consider next to advance our understanding and practice of telehealth. | 2020-07-10 |
| 32643844 | Increased remote support by ED services enabled the continuation of treatment and self-management resources and strategies promoted self-efficacy in both groups. | 2020-07-10 |
| 32643874 | Therefore, antihypertensive therapy with these agents should be continued. | 2020-07-10 |
| 32644205 | Fingolimod is a drug used for immune therapy in patients with multiple sclerosis (MS) through the sequestration of activated lymphocytes in the lymph nodes. | 2020-07-10 |
| 32644223 | Univariate regression analysis showed that disease severity, corticosteroid therapy, fever (temperature>38.5°C), and time from onset to hospitalization were associated with prolonged duration of viral shedding (P < .05). […] Multivariate regression analysis showed that fever (temperature>38.5°C) (OR, 5.1, 95%CI: 1.5-18.1), corticosteroid therapy (OR, 6.3, 95%CI: 1.5-27.8), and time from onset to hospitalization (OR, 1.8, 95%CI: 1.19-2.7) were associated with increased odds of prolonged duration of viral shedding. […] Corticosteroid treatment, fever (temperature>38.5°C), and longer time from onset to hospitalization were associated with prolonged viral shedding in COVID-19 patients. | 2020-07-10 |
| 32644224 | Hydroxychloroquine sulfate (HCQ) is being scrutinized for repositioning in the treatment and prevention of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. […] Cross linking the two sets of data has allowed us to compare the proportion of HCQ chronic treatment (at least 2 grams per month) in laboratory confirmed cases of SARS-CoV-2 infection with laboratory confirmed negative cases. […] After adjustment for age, sex, and chronic treatment with corticosteroids and/or immunosuppressants, the odds ratio of SARS-CoV-2 infection for chronic treatment with HCQ has been 0.51 (0.37-0.70). […] Our data suggest that chronic treatment with HCQ confer protection against SARS-CoV-2 infection. | 2020-07-10 |
| 32644254 | IL-6, C-reactive protein (CRP), ferritin, lactate dehydrogenase (LDH), D-dimer, and procalcitonin were monitored on days 0, 3, and 6 of therapy. […] CRP, ferritin, LDH, and D-dimer levels were reduced after TCZ therapy. | 2020-07-10 |
| 32644765 | The risk of experiencing adverse outcomes from the coronavirus disease 2019 (COVID-19), such as hospitalization, admission to intensive care units and death, is elevated for older individuals and those with certain underlying health conditions including diabetes, chronic conditions affecting lungs, heart or kidneys, and a compromised immune system. | 2020-07-10 |
| 32644868 | Individuals with eating disorders (EDs) are at significant risk for increases in symptomatology and diminished treatment access during the COVID-19 pandemic. | 2020-07-10 |
| 32644876 | This paper aimed to investigate the effect of nutrients on the immune system and their possible roles in the prevention, treatment, and management of COVID-19 in adults. […] Following a balanced diet and supplementation with proper nutrients may play a vital role in prevention, treatment, and management of COVID-19. | 2020-07-10 |
| 32644878 | With ongoing advances patients may benefit from improved detection and earlier treatment of eye diseases, resulting in better care and improved visual outcomes. | 2020-07-10 |
| 32645151 | Available data on comorbidity, laboratory parameters, treatment administered, neuroimaging, neuropathological studies and clinical evolution during hospitalization, measured by the modified Rankin scale, were analysed. | 2020-07-10 |
| 32645175 | One neonate received antiviral therapy with remdesivir and is, to our knowledge, the youngest patient to receive this drug for COVID-19. | 2020-07-10 |
| 32645311 | The COVID-19 pandemic has seen a surge of patients with acute respiratory distress syndrome (ARDS) in intensive care units across the globe. […] Personalised lung-protective mechanical ventilation reduces mortality and has become the mainstay of treatment in ARDS. | 2020-07-10 |
| 32645391 | Thus, new ideas for an appropriated assessment of patients’ condition and clinical treatment are of utmost importance. | 2020-07-10 |
| 32645436 | Daylight photodynamic therapy (dPDT) is an effective and patient preferred treatment that uses sunlight to clear AK. […] Currently, there is no standardised method for measuring the light received during treatment. […] The application also provides forecast of expected radiant exposures for 24- and 48-hs prior to the treatment period. […] Agreement between direct ground measurements and satellite-determined radiant exposure for 2-h treatment was excellent at -0.1 % ± 5.1 % (mean ± standard deviation). […] Relative Root Mean Square of the Error (RMSEr) demonstrated that agreement improved as time to treatment reduced (RMSEr = 22.5 % (48 -hs), 11.2 % (24-hs), 5.2 % (real-time)). | 2020-07-10 |
| 32645478 | More data are needed to evaluate HCQ in the context of COVID-19 treatment. | 2020-07-10 |
| 32645614 | This model can potentially be used to identify patients at risks of developing severe disease in the early stage and therefore guide treatment decisions. | 2020-07-10 |
| 32645630 | There is no vaccine or specific antiviral treatment for HCoVs infection. | 2020-07-10 |
| 32645632 | In this paper, we will elaborate the role of cytokine storm mediated by JAK-STAT pathway in severe COVID-19, the possible mechanisms of baricitinib on reducing the viral entry into the target cells and cytokine storm, the key points of pharmaceutical care based on the latest research reports, clinical trials progress and drug instruction from the US FDA, so as to provide reference for the treatment of severe COVID-19. | 2020-07-10 |
| 32645633 | For decades, antibodies and antibody fragments have occupied a significant body of the treatment approaches against infectious diseases. | 2020-07-10 |
| 32645636 | Current treatment includes long-term use of immunomodulatory therapies, leading to increased rates of infections among this population. | 2020-07-10 |
| 32645876 | This paper proposes that a model of tele-rehabilitation is integrated within the pathway by using digital communication technology to offer quick remote assessment and efficient therapy delivery to these patients. | 2020-07-11 |
| 32645974 | Lack of targeted therapeutics led to the idea of repurposing broad-spectrum drugs for viral intervention. | 2020-07-11 |
| 32646015 | Lastly, 56 °C-30 min treatment of serum specimens had a negligible influence on the results of IgG detection using a commercial ELISA test, whereas a drastic decrease in neutralizing titers was observed. | 2020-07-11 |
| 32646061 | When compiled, this evidence suggests that ergothioneine has a potential application in the treatment of the underlying pathology of COVID-19. | 2020-07-11 |
| 32646234 | Therefore, for some suspected children with COVID-19, we can make a comprehensive judgment through clinical symptoms, epidemiological history, LYM number, myocardial enzyme spectrum, chest CT, and electrocardiogram; put these children in an isolation ward for treatment; and then transfer them to a general ward for treatment after excluding COVID-19. | 2020-07-11 |
| 32646343 | Finally, respondents were asked whether a teleconsultation was carried out before sending patients their medication and whether these deliveries were recorded. […] Before the beginning of the crisis, 83.2% (n = 154) of hospital pharmacy services did not carry out remote pharmaceutical care activities that included telepharmacy with remote delivery of medication. […] During the study period, 119,972 patients were treated, with 134,142 deliveries of medication being completed. […] The means used to deliver the medication mainly included the use of external courier services (47.0%; 87 hospitals) or the hospital’s own transport services (38.4%; 71 hospitals). | 2020-07-11 |
| 32646502 | The aim of this study is to explore the effectiveness and safety of oral corticosteroids (prednisone) in the treatment of early stage SARS-Cov-2 pneumonia in patients who do not yet meet hospital admission criteria. […] Eligible patients will be randomized to receive standard outpatient treatment only (group 1) or standard outpatient treatment plus prednisone (group 2). - Group 1: paracetamol 1 g/8 h (on demand) + hydroxychloroquine 400 mg/12h the first day, 200 mg/12 h for 4 days + azithromycin 500 mg/24h for 5 days. - Group 2: paracetamol 1 g/8 h (on demand) + hydroxychloroquine 400 mg/12h the first day, 200 mg/12 h for 4 days + azithromycin 500 mg/24h for 5 days + prednisone 60 mg / 24 h for 3 days, 30 mg / 24 h for 3 days and 15 mg / 24 h for 3 days. […] Treatment will be assigned according to stratified randomization by the presence or absence of radiological data of lung involvement (previously performed by random sequence 1:1 generated with Epidat and kept hidden by opaque, sealed envelopes, which will only be opened after inclusion and basal measurement). […] The trial was registered under the title “OUTPATIENT TREATMENT OF EARLY PULMONARY COVID19 WITH CORTICOSTEROIDS AS AN OPPORTUNITY TO MODIFY THE COURSE OF THE DISEASE” with EudraCT number 2020-001622-64 , registered on 3 April 2020. | 2020-07-11 |
| 32646505 | Indications for therapy and fractionation schemes were adapted when possible. […] The start of the treatment for the PCR-positive patient was deferred for 2 weeks. | 2020-07-11 |
| 32646545 | Chief complaints of patients admitted to hospitals changed drastically in the proceeding months, which worsened the treatment of many acute and chronic conditions involving cardiovascular system pathologies and resources were moved in order to fight COVID-19. | 2020-07-11 |
| 32646669 | Thus, a systematic review has been performed to define the role of D-dimer in the disease, the prevalence of DIC and the usefulness of anticoagulant treatment in these patients. […] The present review suggests the presence of higher levels of D-dimer in those with worse prognosis, there may be an overdiagnosis of DIC in the course of the disease and there is no evidence on the benefit of starting anticoagulant treatment based only on isolated laboratory data. | 2020-07-11 |
| 32646770 | Epidemiologic, demographic, laboratory, prognostic scores, treatment, and outcome data were collected and analyzed. | 2020-07-11 |
| 32646885 | Of the entire group, 64 (84%) patients were on disease-modifying therapy (DMT) including anti-CD20 therapies (n = 34, 44.7%) and sphingosine-1-phosphate receptor modulators (n = 10, 13.5%). | 2020-07-11 |
| 32646930 | Interleukin 1 (IL-1) is a potential target of therapy in COVID-19 during the severe respiratory-inflammatory phase (“cytokine release syndrome”), when pulmonary macrophages are hyperactivated, releasing IL-1 and other cytokines. | 2020-07-11 |
| 32647324 | Only 60 patients (39.7%) with severe COVID-19 were receiving or had recent (≤12 months) treatment for CLL at the time of COVID-19 versus 30/39 (76.9%) patients with mild disease. […] Hospitalization rate for severe COVID-19 was lower (p < 0.05) for patients on ibrutinib versus those on other regimens or off treatment. […] In CLL, (1) COVID-19 severity increases with age; (2) antileukemic treatment (particularly BTK inhibitors) appears to exert a protective effect; (3) age and comorbidities did not impact on mortality, alluding to a relevant role of CLL and immunodeficiency. | 2020-07-11 |
| 32647390 | The absence of any known treatment procedures, drugs, or vaccines has created panic around the World. | 2020-07-11 |
| 32647672 | We report the epidemiology, radiological characteristics, treatment, and clinical outcomes of these patients. | 2020-07-11 |
| 32647674 | Based on the lean management model, the research group established a process of less-link visits, which sees reduced contact between patients and physicians during diagnosis and treatment, and zero-contact consultation through lean workflow and value stream analysis. […] The median waiting time for image examination has been reduced from 40 to 3 minutes, and the moving distance has been shortened from 800 to 10 m; (V) the diagnosis and treatment process is facilitated by 5G, achieving zero contact between doctors and patients. | 2020-07-11 |
| 32647807 | Plasma from patients that have overcome COVID-19 infection, referred to as convalescent plasma, is a treatment option with considerable background in viral diseases such as Spanish influenza, H1N1, Ebola, Severe Acute Respiratory Syndrome (SARS), and Middle East Respiratory Syndrome (MERS). […] Although convalescent plasma has historically proven beneficial in the treatment of some viral diseases, its use is still explorative in the context of COVID-19. […] A detailed overview of randomized as well non-randomized trials of treatment with convalescent plasma, which have been registered worldwide, is provided in this review. […] This treatment should be administered as early as possible to maximize efficacy, but at the same time be reserved for severe cases. | 2020-07-11 |
| 32648153 | Therefore, chloroquine is considered as a treatment option for coronavirus disease 2019 (COVID-19). […] Furthermore, the number of patients who prematurely discontinued treatment or had an adjustment in dose due to QTc-interval prolongation was established. […] A retrospective, observational study was performed in patients aged over 18 years, hospitalised for a suspected or proven infection with COVID-19, and therefore treated with chloroquine, with a baseline electrocardiogram (ECG) performed prior to the start of treatment and at least one ECG after starting the treatment. […] The mean increase in QTc interval throughout the treatment with chloroquine was 33 ms. […] Nineteen out of 344 patients unnecessarily had their treatment prematurely discontinued or adjusted due to a prolonged QTc interval based on the computerised interpretation of the ECG. […] Chloroquine treatment in COVID-19 patients gradually increased the QTc interval. […] Due to a significant number of overestimated QTc intervals by computer analysis, it is advisable to measure the QTc interval manually before adjusting the dose or withdrawing this potentially beneficial medication. | 2020-07-11 |
| 32648245 | At this time there is no particular therapy, drug or vaccine available to deal with COVID-19. […] Although mild cases of COVID-19 can be controlled with antiviral, anti-inflammatory and immunomodulatory treatment, severe cases may need intensive care unit support and ventilation. | 2020-07-11 |
| 32648313 | Some potential immunotherapeutic strategies to control the progression of COVID-19, such as passive antibody therapy and use of interferon αβ and IL-6 receptor (IL-6R) inhibitor, have also been discussed. | 2020-07-11 |
| 32648389 | Combined with previous clinical experience in anti-epidemic and acupuncture, the prevention program of fire needling therapy for coronavirus disease 2019 (COVID-19) was drawn out. […] Fire needling therapy has the effects of clearing heat, removing dampness, replenishing for the deficiency, removing stasis and detoxifying, which is mainly aimed at preventing populations, light and common types cases, and cases in the recovery period. […] It is hoped that fire needling therapy will be applied in the community and square cabin hospitals as an effective supplement to anti-epidemic of traditional Chinese medicine (TCM). | 2020-07-11 |
| 32648592 | Several health organizations have concluded that treatment with corticosteroids during active infection should be avoided due to concerns of prolonged viral shedding in the respiratory tract and the lack of survival benefit based on the data from past coronaviruses and influenza virus; specific exceptions exist including treatment for underlying asthma or chronic obstructive pulmonary disease, septic shock, and acute respiratory distress syndrome. […] It is recommended that prior to prescribing non-steroidal anti-inflammatory drugs and steroids for the treatment of headache, clinicians have open discussions with their patients about the potential risks and benefits of using these medications during the COVID-19 pandemic. | 2020-07-11 |
| 32648667 | Importantly, cancer therapeutics could potentially render cancer patients more susceptible to demise from COVID-19 yet the poor survival outcome of many cancer diagnoses outweighs this risk. | 2020-07-11 |
| 32648899 | Treatment for individuals with COVID-19 includes best practices for supportive management of acute hypoxic respiratory failure. […] Emerging data indicate that dexamethasone therapy reduces 28-day mortality in patients requiring supplemental oxygen compared with usual care (21.6% vs 24.6%; age-adjusted rate ratio, 0.83 [95% CI, 0.74-0.92]) and that remdesivir improves time to recovery (hospital discharge or no supplemental oxygen requirement) from 15 to 11 days. […] Many aspects of transmission, infection, and treatment remain unclear. | 2020-07-11 |
| 32648950 | Childhood cancer is a highly curable disease when timely diagnosis and appropriate therapy are provided. […] Almost all centers applied guidelines to optimize resource utilization and safety, including delaying off-treatment visits, rotating and reducing staff, and implementing social distancing, hand hygiene measures, and personal protective equipment use. […] Essential treatments, including chemotherapy, surgery, and radiation therapy, were delayed in 29% to 44% of centers, and 24% of centers restricted acceptance of new patients. […] Greater than 70% of centers reported shortages in blood products, and 47% to 62% reported interruptions in surgery and radiation as well as medication shortages. […] Mechanisms to approach childhood cancer treatment delivery during crises need to be re-evaluated, because treatment interruptions and delays are expected to affect patient outcomes in this otherwise largely curable disease. | 2020-07-11 |
| 32648959 | Convalescent plasma and hyperimmune immunoglobulin may reduce mortality in patients with viral respiratory diseases, and are currently being investigated in trials as potential therapy for coronavirus disease 2019 (COVID-19). […] OBJECTIVES: To continually assess, as more evidence becomes available, whether convalescent plasma or hyperimmune immunoglobulin transfusion is effective and safe in treatment of people with COVID-19. […] Control groups received standard care at time of treatment without convalescent plasma. […] We are very uncertain whether or not convalescent plasma therapy affects the risk of moderate to severe adverse events (very low-certainty evidence). | 2020-07-11 |
| 32649222 | The best cut-offs for death prediction were >731 U/L for lactate dehydrogenase and ≤18 g/L for albumin, while a lactate dehydrogenase activity <425 U/L was associated with a negative likelihood ratio of 0.10 for intensive treatment. | 2020-07-11 |
| 32649262 | Aim of this communication is to remind clinical professionals to be aware of ototoxic side effects of several specific drugs proposed for the treatment of the new virus SARS-CoV-2 (Covid-19). | 2020-07-11 |
| 32649266 | Aim: To examine the effect of rapid scaling of tobacco treatment telehealth on patient engagement, as measured by attendance rates for in-person counseling visits versus remote telehealth counseling visits. […] Methods: Data collected from the electronic medical record during the first 4 months of the COVID-19 pandemic were examined for tobacco treatment counseling. […] Results: From January 1, 2020 to March 30, 2020, markedly improved patient engagement was observed in ambulatory tobacco treatment services with greater attendance at scheduled telehealth visits than in-person visits, 75% versus 60.3%, odds ratio 1.84 (confidence interval: 1.26-2.71; p < 0.001). […] Discussion: Clinical, Information Technology (IT), and hospital system barriers were successfully addressed for most cancer patients seeking individual telehealth treatment. […] Conclusions: MSK’s rapid leap into virtual care delivery mitigated disruption of tobacco treatment services and demonstrated strong feasibility and acceptance for managing complex tobacco-dependent patients. | 2020-07-11 |
| 32649272 | Clinical recommendations are given for prevention and treatment of COVID-19. […] Our group is working with the Academy of Nutrition and Dietetics to collect patient-level data from intensive care units across the United States to better understand nutrition care practices that lead to better outcomes. | 2020-07-11 |
| 32649301 | Unfortunately, this pandemic is expected to make a resurgence in the fall, but hopefully more will be known about SARS-CoV-2, better treatment protocols will be established, and, possibly, a safe and effective vaccine will be developed and available soon. | 2020-07-11 |
| 32649560 | Despite that a maxillofacial department is not a frontline specialty in the treatment of coronavirus disease 2019 infections, our department has found itself faced with numerous problems in keeping the care system active and efficient while ensuring safety for patients and healthcare professionals. […] This article outlines new guidelines for infection prevention: from clinical control, treatment processes, clinical management, protection, and disinfection of healthcare professionals. | 2020-07-11 |
| 32649713 | Owing to uncertainties and crisis amid the pandemic, as an emergency announcement, the World Health Organization (WHO) solicits the help of health authorities, especially, researchers to conduct in-depth research on the evolution and treatment of COVID-19. | 2020-07-11 |
| 32649747 | Personalized treatment decisions decreased early mortality (OR 0.144, CI 0.03-0.686; p=0.015). | 2020-07-11 |
| 32649791 | Clinical presentation, laboratory values, immunosuppression and treatment strategies were reviewed and predictors of poor clinical outcomes were determined through multivariable analyses. | 2020-07-11 |
| 32649840 | Nevertheless, further studies are needed focusing on the preexisting hepatic diseases on prevention, treatment and outcome of COVID-19. | 2020-07-11 |
| 32649988 | This review aims to understand the viral load of SARS-CoV-2 in faeces and sewage and its fate in wastewater treatment plants (WWTPs). […] The detection of SARS-CoV-2 in sewage, based on RNA sequences and RT-PCR, requires a shared approach on sample pre-treatment and on-site collection to ensure comparable results. […] In sludge treatment, thermophilic digestion is effective, based on the general consensus that CoVs are highly sensitive to increased temperatures. | 2020-07-11 |
| 32650121 | Neurologists are interested in understanding whether patients with multiple sclerosis (pwMS) undergoing immunomodulatory/immunosuppressive therapy are more susceptible to developing COVID-19 or have worse outcomes. | 2020-07-11 |
| 32650189 | EMA decided that with ulipristal acetate (UPA) treatment for uterine fibroids, should be discontinued due to the associated risk of hepatic failure, We analyzed whether the risk of recurrent symptoms due to fibroids may lead to an increased risk of Covid -19 infection and death, that would exceed the former risk of hepatic failure and transplantation. […] Our calculations suggest that the decision to stop UPA in the middle of the Covid- 19 pandemic may be untimely, since it may result in an increased risk of Covid-19 infection, due to the recurrence of symptoms and the need for medical and surgical treatment. | 2020-07-11 |
| 32650215 | As such, lung cancer patients must be prioritized in terms of prevention, detection and treatment. […] Special care must be taken to maintain treatment while avoiding exposure. | 2020-07-11 |
| 32650220 | This has presented a critical challenge for the delivery of exposure and response prevention (ERP) therapy to individuals with contamination fears due to Obsessive Compulsive Disorder (OCD), as providers must manage not only their clients’ attitudes and reactions but their own as well. […] In this investigation, self-identified anxiety and OCD treatment specialists (N = 139) provided demographic information, including their anxiety and OCD caseloads, and completed measures related to intolerance of uncertainty (IUS-SF; Carlton et al., 2007), beliefs about exposure therapy (TBES; Deacon et al., 2013), and emotional reactions to physical sensations (The Chills; Maruskin et al., 2012). […] Findings are useful in determining methods for aiding clinicians in developing effective approaches to contamination fears during and post-pandemic that include addressing their own BIS-related concerns and mapping out means for social behavioral norms associated with engaging in exposure treatment. | 2020-07-11 |
| 32650354 | Data on the association between obesity and COVID-19 are growing; the available studies, have reported a high prevalence of overweight and obesity in patients experiencing a severe COVID-19 course, with serious complications requiring hospitalization and admission to intensive care units. […] Patients with obesity require preferential access dedicated to primary care services to ensure they are regularly taking their medications for the treatment of any concurrent chronic diseases. | 2020-07-11 |
| 32650355 | It is a very complex systemic disease in terms of pathogenesis, treatment, and prognosis. […] Pharmacological treatment may include antiviral and antimalarial drugs, antibiotics, monoclonal antibodies, corticosteroids as well as low-molecular-weight heparins to prevent the evolution of the disease from reaching the severe inflammatory phase that can lead to respiratory complications, multiple organ failure, disseminated intravascular coagulation (DIC), and finally death. | 2020-07-11 |
| 32650356 | His condition improved, and in the ensuing days, the treatment gradually switched to a high-flow nasal cannula (HFNC); after 18 days, the patient’s clinical condition was good.The successful results we have been able to obtain are closely associated with avoidance of invasive ventilation that may lead to intensive care unit (ICU)-related superinfections. | 2020-07-11 |
| 32650409 | Belief in conspiracy regarding the origin of COVID-19 was associated with misinformation about the availability of a vaccine and the therapeutic use of antibiotics for COVID-19 treatment. | 2020-07-12 |
| 32650523 | Multi-variable analyses confirmed age > 65 and > 2 co-morbidities to predict for patient mortality independent of tumor stage, active malignancy, or anticancer therapy. | 2020-07-12 |
| 32650681 | Other differences related to knowledge of COVID-19 were symptoms, treatment, ways of spreading (p < .001), prevention by avoiding crowded places (p = .008) and isolation (p = .002). […] Multivariate stepwise regression analysis indicated that level of education, avoiding going to crowded places, eye, nose and mouth organs are sensitive organs to the virus, keeping physical distance due to epidemic affect by COVID-19 virus, isolation and treatment of people reduce the spread of COVID-19 virus and 14-days period of time, COVID-19 is mainly transmitted through contact with the respiratory droplets of an infected person, occupational status, health education programme needed and antibody treatment variables were significantly associated with fatigue after adjusting for age, gender and income variables. | 2020-07-12 |
| 32650756 | Numerous cancer patients from non-Western countries, including the United Arab Emirates (UAE), seek cancer care outside their home countries and many are sponsored by their governments for treatment. […] Many patients interrupted their cancer treatment abruptly and so returned to their home countries with unique challenges. […] In this review we will discuss practical challenges and recommendations for all cancer patients returning to their home countries from treatment abroad. […] The taskforce which consisted of experts from medical oncology, hematology, surgical oncology, radiation oncology, pathology, radiology and palliative care summarized the current challenges and suggested a practical approaches to address these specific challenges to improve the returning cancer patients care. […] Difference in approaches and treatment recommendations between the existing treating oncologists abroad and receiving oncologists in the UAE regarding the optimal management which can be addressed by early and empathic communications with patients and by engaging the previous treating oncologists in treatment planning based on the available resources and expertise in the UAE. […] Interruption of curative radiotherapy (RT) schedules which can potentially increase risk of treatment failure has been a major challenge, RT dose-compensation calculation should be considered in these circumstances. […] This pandemic may also serve as an opportunity to encourage patients to receive treatment locally in their home country. […] Future studies will be needed to address the steps to retain cancer patients in the UAE rather than seeking cancer treatment abroad. | 2020-07-12 |
| 32650818 | The aim of this trial is to identify the effect of ambulatory treatment in early COVID-19 disease with hydroxychloroquine on the rate of hospitalization or death in older patients above the age of 64. […] Patients and investigators, as well as treating physicians are blinded to the treatment- allocation. | 2020-07-12 |
| 32650840 | Five early actions (early detection, early reporting, early diagnosis, early isolation, and early treatment) and four centralized responses (centralized coordination by experts, centralized allocation of resources, centralized placement of patients, and centralized provision of treatment) ensured effective prevention and control. | 2020-07-12 |
| 32651031 | The current clinical management of diabetes is a work in progress, requiring a shift in patient-provider interaction beyond the walls of clinics and hospitals: the use of tele-medicine when feasible, innovative patient education programs, strategies to ensure medication and glucose testing availability and affordability, as well as numerous ideas on how to improve meal plans and physical activity. | 2020-07-12 |
| 32651067 | ARB treatment was associated with a significantly lower risk of hospitalization (HR: 0.29, 95% CI: 0.10 - 0.88). […] ARB or ACEI treatment was not associated with a worse clinical outcome in consecutive hypertensive patients infected by SARS-CoV-2. | 2020-07-12 |
| 32651106 | This suite of complementary tests will inform crucial decisions by healthcare providers and policy makers, and understanding their strengths and limitations will be critical to their judicious application for the development of algorithmic approaches to treatment and public health strategies. | 2020-07-12 |
| 32651176 | Adoption of new methods should be based on clinical judgement, the weight of evidence and the balance of probabilities that any new technique, test or treatment might work. | 2020-07-12 |
| 32651218 | Currently there are few treatment options for SARS-CoV-2 infections. […] These findings provide a basis for testing the potential use of therapies directed at modulation of Th17 cells and IL-17A signaling in the treatment of COVID-19. | 2020-07-12 |
| 32651254 | The COVID-19 pandemic has introduced new ethical challenges in the care of patients with serious psychiatric illness who require inpatient treatment and who may have beeen exposed to COVID-19 or have mild to moderate COVID-19 but refuse testing and adherence to infection prevention protocols. | 2020-07-12 |
| 32651513 | As the government’s coronavirus (COVID-19) lockdown starts to be eased and the NHS starts entering phase two of its response to the COVID-19 pandemic, dental practices are expecting a sharp increase in the need for dental treatment. | 2020-07-12 |
| 32651586 | It is important to develop vaccines that can also mediate T-cell responses to SARS-CoV-2 to limit severity of infections, and to analyze the cellular immunome in the use of anti-SARS-CoV-2 therapeutics. | 2020-07-12 |
| 32651664 | In light of the recent retraction of the New England Journal of Medicine article entitled “Cardiovascular Disease, Drug Therapy, and Mortality in COVID-19” (Mehra et al., full citation provided below), the authors would like to remove the following statement, which appeared on page 2, under the heading Cardiovascular Disease and COVID-19. | 2020-07-12 |
| 32651686 | In this unprecedented COVID-19 pandemic, several key issues must be addressed to ensure safe treatment and prevent rapid spread of the virus and a consequential medical crisis. […] As functionality of the medical care system is greatly affected by the environmental situation, the treatment may differ according to the medical and infectious disease circumstances of the institution. […] In this article, the Japan Surgical Society addresses the general principles of surgical treatment in relation to COVID-19 infection and advocates preventive measures against viral transmission during this unimaginable COVID-19 pandemic. | 2020-07-12 |
| 32651894 | After two negative Covid tests were obtained, three patients with macro GH-secreting tumors, and two patients with micro ACTH-secreting tumors resistant to medical treatment underwent surgery during the pandemic. | 2020-07-12 |
| 32651936 | Here, we summarize the TCM-related measures that were widely used in China, including TCM guidelines, the Wuchang pattern, mobile cabin hospitals, integrated treatment of TCM and modern medicine for critical patients, and non-medicine therapy for convalescent patients, and describe how TCM effectively treated patients afflicted with the COVID-19. | 2020-07-12 |
| 32651941 | Remdesivir is a nucleoside antiviral recently studied in several randomized trials for treatment of COVID-19. […] The available observational and prospective data are conflicting, requiring clinicians to critically evaluate and reconcile results to determine patient populations that may optimally benefit from remdesivir therapy, especially while drug supply is scarce. | 2020-07-12 |
| 32651959 | This review systematically summarizes the immune-pathobiological characteristics, diagnosis, potential therapeutic options for the treatment and prevention of COVID-19 based on the current published literature and evidence. […] In addition, possible therapeutic interventions, treatment strategies and vaccine development initiatives to manage COVID-19 have been proposed. | 2020-07-12 |
| 32651961 | This review will focus on the antiviral mechanism, effectiveness and safety, dosage and DDIs of chloroquine, for the purpose to provide evidence-based support for rational use of chloroquine in the treatment of COVID-19. […] However, studies of effectiveness and safety on chloroquine treatment of COVID-19 for the general and geriatric patients are not enough. […] Although there have been reports of successful clinical application of chloroquine in treatment COVID-19，more clinical test data are still needed to prove its effectiveness and safety. | 2020-07-12 |
| 32651961 | This review will focus on the antiviral mechanism, effectiveness and safety, dosage and DDIs of chloroquine, for the purpose to provide evidence-based support for rational use of chloroquine in the treatment of COVID-19. […] However, studies of effectiveness and safety on chloroquine treatment of COVID-19 for the general and geriatric patients are not enough. […] Although there have been reports of successful clinical application of chloroquine in treatment COVID-19，more clinical test data are still needed to prove its effectiveness and safety. | 2020-07-12 |
| 32651961 | This review will focus on the antiviral mechanism, effectiveness and safety, dosage and DDIs of chloroquine, for the purpose to provide evidence-based support for rational use of chloroquine in the treatment of COVID-19. […] However, studies of effectiveness and safety on chloroquine treatment of COVID-19 for the general and geriatric patients are not enough. […] Although there have been reports of successful clinical application of chloroquine in treatment COVID-19，more clinical test data are still needed to prove its effectiveness and safety. | 2020-07-12 |
| 32651961 | This review will focus on the antiviral mechanism, effectiveness and safety, dosage and DDIs of chloroquine, for the purpose to provide evidence-based support for rational use of chloroquine in the treatment of COVID-19. […] However, studies of effectiveness and safety on chloroquine treatment of COVID-19 for the general and geriatric patients are not enough. […] Although there have been reports of successful clinical application of chloroquine in treatment COVID-19，more clinical test data are still needed to prove its effectiveness and safety. | 2020-07-12 |
| 32651961 | This review will focus on the antiviral mechanism, effectiveness and safety, dosage and DDIs of chloroquine, for the purpose to provide evidence-based support for rational use of chloroquine in the treatment of COVID-19. […] However, studies of effectiveness and safety on chloroquine treatment of COVID-19 for the general and geriatric patients are not enough. […] Although there have been reports of successful clinical application of chloroquine in treatment COVID-19，more clinical test data are still needed to prove its effectiveness and safety. | 2020-07-12 |
| 32651961 | This review will focus on the antiviral mechanism, effectiveness and safety, dosage and DDIs of chloroquine, for the purpose to provide evidence-based support for rational use of chloroquine in the treatment of COVID-19. […] However, studies of effectiveness and safety on chloroquine treatment of COVID-19 for the general and geriatric patients are not enough. […] Although there have been reports of successful clinical application of chloroquine in treatment COVID-19，more clinical test data are still needed to prove its effectiveness and safety. | 2020-07-12 |
| 32651961 | This review will focus on the antiviral mechanism, effectiveness and safety, dosage and DDIs of chloroquine, for the purpose to provide evidence-based support for rational use of chloroquine in the treatment of COVID-19. […] However, studies of effectiveness and safety on chloroquine treatment of COVID-19 for the general and geriatric patients are not enough. […] Although there have been reports of successful clinical application of chloroquine in treatment COVID-19，more clinical test data are still needed to prove its effectiveness and safety. | 2020-07-12 |
| 32651961 | This review will focus on the antiviral mechanism, effectiveness and safety, dosage and DDIs of chloroquine, for the purpose to provide evidence-based support for rational use of chloroquine in the treatment of COVID-19. […] However, studies of effectiveness and safety on chloroquine treatment of COVID-19 for the general and geriatric patients are not enough. […] Although there have been reports of successful clinical application of chloroquine in treatment COVID-19，more clinical test data are still needed to prove its effectiveness and safety. | 2020-07-12 |
| 32651961 | This review will focus on the antiviral mechanism, effectiveness and safety, dosage and DDIs of chloroquine, for the purpose to provide evidence-based support for rational use of chloroquine in the treatment of COVID-19. […] However, studies of effectiveness and safety on chloroquine treatment of COVID-19 for the general and geriatric patients are not enough. […] Although there have been reports of successful clinical application of chloroquine in treatment COVID-19，more clinical test data are still needed to prove its effectiveness and safety. | 2020-07-12 |
| 32651961 | This review will focus on the antiviral mechanism, effectiveness and safety, dosage and DDIs of chloroquine, for the purpose to provide evidence-based support for rational use of chloroquine in the treatment of COVID-19. […] However, studies of effectiveness and safety on chloroquine treatment of COVID-19 for the general and geriatric patients are not enough. […] Although there have been reports of successful clinical application of chloroquine in treatment COVID-19，more clinical test data are still needed to prove its effectiveness and safety. | 2020-07-12 |
| 32651961 | This review will focus on the antiviral mechanism, effectiveness and safety, dosage and DDIs of chloroquine, for the purpose to provide evidence-based support for rational use of chloroquine in the treatment of COVID-19. […] However, studies of effectiveness and safety on chloroquine treatment of COVID-19 for the general and geriatric patients are not enough. […] Although there have been reports of successful clinical application of chloroquine in treatment COVID-19，more clinical test data are still needed to prove its effectiveness and safety. | 2020-07-12 |
| 32651961 | This review will focus on the antiviral mechanism, effectiveness and safety, dosage and DDIs of chloroquine, for the purpose to provide evidence-based support for rational use of chloroquine in the treatment of COVID-19. […] However, studies of effectiveness and safety on chloroquine treatment of COVID-19 for the general and geriatric patients are not enough. […] Although there have been reports of successful clinical application of chloroquine in treatment COVID-19，more clinical test data are still needed to prove its effectiveness and safety. | 2020-07-12 |
| 32651961 | This review will focus on the antiviral mechanism, effectiveness and safety, dosage and DDIs of chloroquine, for the purpose to provide evidence-based support for rational use of chloroquine in the treatment of COVID-19. […] However, studies of effectiveness and safety on chloroquine treatment of COVID-19 for the general and geriatric patients are not enough. […] Although there have been reports of successful clinical application of chloroquine in treatment COVID-19，more clinical test data are still needed to prove its effectiveness and safety. | 2020-07-12 |
| 32651961 | This review will focus on the antiviral mechanism, effectiveness and safety, dosage and DDIs of chloroquine, for the purpose to provide evidence-based support for rational use of chloroquine in the treatment of COVID-19. […] However, studies of effectiveness and safety on chloroquine treatment of COVID-19 for the general and geriatric patients are not enough. […] Although there have been reports of successful clinical application of chloroquine in treatment COVID-19，more clinical test data are still needed to prove its effectiveness and safety. | 2020-07-12 |
| 32651961 | This review will focus on the antiviral mechanism, effectiveness and safety, dosage and DDIs of chloroquine, for the purpose to provide evidence-based support for rational use of chloroquine in the treatment of COVID-19. […] However, studies of effectiveness and safety on chloroquine treatment of COVID-19 for the general and geriatric patients are not enough. […] Although there have been reports of successful clinical application of chloroquine in treatment COVID-19，more clinical test data are still needed to prove its effectiveness and safety. | 2020-07-12 |
| 32651961 | This review will focus on the antiviral mechanism, effectiveness and safety, dosage and DDIs of chloroquine, for the purpose to provide evidence-based support for rational use of chloroquine in the treatment of COVID-19. […] However, studies of effectiveness and safety on chloroquine treatment of COVID-19 for the general and geriatric patients are not enough. […] Although there have been reports of successful clinical application of chloroquine in treatment COVID-19，more clinical test data are still needed to prove its effectiveness and safety. | 2020-07-12 |
| 32651961 | This review will focus on the antiviral mechanism, effectiveness and safety, dosage and DDIs of chloroquine, for the purpose to provide evidence-based support for rational use of chloroquine in the treatment of COVID-19. […] However, studies of effectiveness and safety on chloroquine treatment of COVID-19 for the general and geriatric patients are not enough. […] Although there have been reports of successful clinical application of chloroquine in treatment COVID-19，more clinical test data are still needed to prove its effectiveness and safety. | 2020-07-12 |
| 32651961 | This review will focus on the antiviral mechanism, effectiveness and safety, dosage and DDIs of chloroquine, for the purpose to provide evidence-based support for rational use of chloroquine in the treatment of COVID-19. […] However, studies of effectiveness and safety on chloroquine treatment of COVID-19 for the general and geriatric patients are not enough. […] Although there have been reports of successful clinical application of chloroquine in treatment COVID-19，more clinical test data are still needed to prove its effectiveness and safety. | 2020-07-12 |
| 32651961 | This review will focus on the antiviral mechanism, effectiveness and safety, dosage and DDIs of chloroquine, for the purpose to provide evidence-based support for rational use of chloroquine in the treatment of COVID-19. […] However, studies of effectiveness and safety on chloroquine treatment of COVID-19 for the general and geriatric patients are not enough. […] Although there have been reports of successful clinical application of chloroquine in treatment COVID-19，more clinical test data are still needed to prove its effectiveness and safety. | 2020-07-12 |
| 32651961 | This review will focus on the antiviral mechanism, effectiveness and safety, dosage and DDIs of chloroquine, for the purpose to provide evidence-based support for rational use of chloroquine in the treatment of COVID-19. […] However, studies of effectiveness and safety on chloroquine treatment of COVID-19 for the general and geriatric patients are not enough. […] Although there have been reports of successful clinical application of chloroquine in treatment COVID-19，more clinical test data are still needed to prove its effectiveness and safety. | 2020-07-12 |
| 32651961 | This review will focus on the antiviral mechanism, effectiveness and safety, dosage and DDIs of chloroquine, for the purpose to provide evidence-based support for rational use of chloroquine in the treatment of COVID-19. […] However, studies of effectiveness and safety on chloroquine treatment of COVID-19 for the general and geriatric patients are not enough. […] Although there have been reports of successful clinical application of chloroquine in treatment COVID-19，more clinical test data are still needed to prove its effectiveness and safety. | 2020-07-12 |
| 32651961 | This review will focus on the antiviral mechanism, effectiveness and safety, dosage and DDIs of chloroquine, for the purpose to provide evidence-based support for rational use of chloroquine in the treatment of COVID-19. […] However, studies of effectiveness and safety on chloroquine treatment of COVID-19 for the general and geriatric patients are not enough. […] Although there have been reports of successful clinical application of chloroquine in treatment COVID-19，more clinical test data are still needed to prove its effectiveness and safety. | 2020-07-12 |
| 32651961 | This review will focus on the antiviral mechanism, effectiveness and safety, dosage and DDIs of chloroquine, for the purpose to provide evidence-based support for rational use of chloroquine in the treatment of COVID-19. […] However, studies of effectiveness and safety on chloroquine treatment of COVID-19 for the general and geriatric patients are not enough. […] Although there have been reports of successful clinical application of chloroquine in treatment COVID-19，more clinical test data are still needed to prove its effectiveness and safety. | 2020-07-12 |
| 32651961 | This review will focus on the antiviral mechanism, effectiveness and safety, dosage and DDIs of chloroquine, for the purpose to provide evidence-based support for rational use of chloroquine in the treatment of COVID-19. […] However, studies of effectiveness and safety on chloroquine treatment of COVID-19 for the general and geriatric patients are not enough. […] Although there have been reports of successful clinical application of chloroquine in treatment COVID-19，more clinical test data are still needed to prove its effectiveness and safety. | 2020-07-12 |
| 32651961 | This review will focus on the antiviral mechanism, effectiveness and safety, dosage and DDIs of chloroquine, for the purpose to provide evidence-based support for rational use of chloroquine in the treatment of COVID-19. […] However, studies of effectiveness and safety on chloroquine treatment of COVID-19 for the general and geriatric patients are not enough. […] Although there have been reports of successful clinical application of chloroquine in treatment COVID-19，more clinical test data are still needed to prove its effectiveness and safety. | 2020-07-12 |
| 32651961 | This review will focus on the antiviral mechanism, effectiveness and safety, dosage and DDIs of chloroquine, for the purpose to provide evidence-based support for rational use of chloroquine in the treatment of COVID-19. […] However, studies of effectiveness and safety on chloroquine treatment of COVID-19 for the general and geriatric patients are not enough. […] Although there have been reports of successful clinical application of chloroquine in treatment COVID-19，more clinical test data are still needed to prove its effectiveness and safety. | 2020-07-12 |
| 32651961 | This review will focus on the antiviral mechanism, effectiveness and safety, dosage and DDIs of chloroquine, for the purpose to provide evidence-based support for rational use of chloroquine in the treatment of COVID-19. […] However, studies of effectiveness and safety on chloroquine treatment of COVID-19 for the general and geriatric patients are not enough. […] Although there have been reports of successful clinical application of chloroquine in treatment COVID-19，more clinical test data are still needed to prove its effectiveness and safety. | 2020-07-12 |
| 32651961 | This review will focus on the antiviral mechanism, effectiveness and safety, dosage and DDIs of chloroquine, for the purpose to provide evidence-based support for rational use of chloroquine in the treatment of COVID-19. […] However, studies of effectiveness and safety on chloroquine treatment of COVID-19 for the general and geriatric patients are not enough. […] Although there have been reports of successful clinical application of chloroquine in treatment COVID-19，more clinical test data are still needed to prove its effectiveness and safety. | 2020-07-12 |
| 32651961 | This review will focus on the antiviral mechanism, effectiveness and safety, dosage and DDIs of chloroquine, for the purpose to provide evidence-based support for rational use of chloroquine in the treatment of COVID-19. […] However, studies of effectiveness and safety on chloroquine treatment of COVID-19 for the general and geriatric patients are not enough. […] Although there have been reports of successful clinical application of chloroquine in treatment COVID-19，more clinical test data are still needed to prove its effectiveness and safety. | 2020-07-12 |
| 32651961 | This review will focus on the antiviral mechanism, effectiveness and safety, dosage and DDIs of chloroquine, for the purpose to provide evidence-based support for rational use of chloroquine in the treatment of COVID-19. […] However, studies of effectiveness and safety on chloroquine treatment of COVID-19 for the general and geriatric patients are not enough. […] Although there have been reports of successful clinical application of chloroquine in treatment COVID-19，more clinical test data are still needed to prove its effectiveness and safety. | 2020-07-12 |
| 32651961 | This review will focus on the antiviral mechanism, effectiveness and safety, dosage and DDIs of chloroquine, for the purpose to provide evidence-based support for rational use of chloroquine in the treatment of COVID-19. […] However, studies of effectiveness and safety on chloroquine treatment of COVID-19 for the general and geriatric patients are not enough. […] Although there have been reports of successful clinical application of chloroquine in treatment COVID-19，more clinical test data are still needed to prove its effectiveness and safety. | 2020-07-12 |
| 32651961 | This review will focus on the antiviral mechanism, effectiveness and safety, dosage and DDIs of chloroquine, for the purpose to provide evidence-based support for rational use of chloroquine in the treatment of COVID-19. […] However, studies of effectiveness and safety on chloroquine treatment of COVID-19 for the general and geriatric patients are not enough. […] Although there have been reports of successful clinical application of chloroquine in treatment COVID-19，more clinical test data are still needed to prove its effectiveness and safety. | 2020-07-12 |
| 32651961 | This review will focus on the antiviral mechanism, effectiveness and safety, dosage and DDIs of chloroquine, for the purpose to provide evidence-based support for rational use of chloroquine in the treatment of COVID-19. […] However, studies of effectiveness and safety on chloroquine treatment of COVID-19 for the general and geriatric patients are not enough. […] Although there have been reports of successful clinical application of chloroquine in treatment COVID-19，more clinical test data are still needed to prove its effectiveness and safety. | 2020-07-12 |
| 32651961 | This review will focus on the antiviral mechanism, effectiveness and safety, dosage and DDIs of chloroquine, for the purpose to provide evidence-based support for rational use of chloroquine in the treatment of COVID-19. […] However, studies of effectiveness and safety on chloroquine treatment of COVID-19 for the general and geriatric patients are not enough. […] Although there have been reports of successful clinical application of chloroquine in treatment COVID-19，more clinical test data are still needed to prove its effectiveness and safety. | 2020-07-12 |
| 32651961 | This review will focus on the antiviral mechanism, effectiveness and safety, dosage and DDIs of chloroquine, for the purpose to provide evidence-based support for rational use of chloroquine in the treatment of COVID-19. […] However, studies of effectiveness and safety on chloroquine treatment of COVID-19 for the general and geriatric patients are not enough. […] Although there have been reports of successful clinical application of chloroquine in treatment COVID-19，more clinical test data are still needed to prove its effectiveness and safety. | 2020-07-12 |
| 32651961 | This review will focus on the antiviral mechanism, effectiveness and safety, dosage and DDIs of chloroquine, for the purpose to provide evidence-based support for rational use of chloroquine in the treatment of COVID-19. […] However, studies of effectiveness and safety on chloroquine treatment of COVID-19 for the general and geriatric patients are not enough. […] Although there have been reports of successful clinical application of chloroquine in treatment COVID-19，more clinical test data are still needed to prove its effectiveness and safety. | 2020-07-12 |
| 32651961 | This review will focus on the antiviral mechanism, effectiveness and safety, dosage and DDIs of chloroquine, for the purpose to provide evidence-based support for rational use of chloroquine in the treatment of COVID-19. […] However, studies of effectiveness and safety on chloroquine treatment of COVID-19 for the general and geriatric patients are not enough. […] Although there have been reports of successful clinical application of chloroquine in treatment COVID-19，more clinical test data are still needed to prove its effectiveness and safety. | 2020-07-12 |
| 32651961 | This review will focus on the antiviral mechanism, effectiveness and safety, dosage and DDIs of chloroquine, for the purpose to provide evidence-based support for rational use of chloroquine in the treatment of COVID-19. […] However, studies of effectiveness and safety on chloroquine treatment of COVID-19 for the general and geriatric patients are not enough. […] Although there have been reports of successful clinical application of chloroquine in treatment COVID-19，more clinical test data are still needed to prove its effectiveness and safety. | 2020-07-12 |
| 32651961 | This review will focus on the antiviral mechanism, effectiveness and safety, dosage and DDIs of chloroquine, for the purpose to provide evidence-based support for rational use of chloroquine in the treatment of COVID-19. […] However, studies of effectiveness and safety on chloroquine treatment of COVID-19 for the general and geriatric patients are not enough. […] Although there have been reports of successful clinical application of chloroquine in treatment COVID-19，more clinical test data are still needed to prove its effectiveness and safety. | 2020-07-12 |
| 32651961 | This review will focus on the antiviral mechanism, effectiveness and safety, dosage and DDIs of chloroquine, for the purpose to provide evidence-based support for rational use of chloroquine in the treatment of COVID-19. […] However, studies of effectiveness and safety on chloroquine treatment of COVID-19 for the general and geriatric patients are not enough. […] Although there have been reports of successful clinical application of chloroquine in treatment COVID-19，more clinical test data are still needed to prove its effectiveness and safety. | 2020-07-12 |
| 32651961 | This review will focus on the antiviral mechanism, effectiveness and safety, dosage and DDIs of chloroquine, for the purpose to provide evidence-based support for rational use of chloroquine in the treatment of COVID-19. […] However, studies of effectiveness and safety on chloroquine treatment of COVID-19 for the general and geriatric patients are not enough. […] Although there have been reports of successful clinical application of chloroquine in treatment COVID-19，more clinical test data are still needed to prove its effectiveness and safety. | 2020-07-12 |
| 32651961 | This review will focus on the antiviral mechanism, effectiveness and safety, dosage and DDIs of chloroquine, for the purpose to provide evidence-based support for rational use of chloroquine in the treatment of COVID-19. […] However, studies of effectiveness and safety on chloroquine treatment of COVID-19 for the general and geriatric patients are not enough. […] Although there have been reports of successful clinical application of chloroquine in treatment COVID-19，more clinical test data are still needed to prove its effectiveness and safety. | 2020-07-12 |
| 32651961 | This review will focus on the antiviral mechanism, effectiveness and safety, dosage and DDIs of chloroquine, for the purpose to provide evidence-based support for rational use of chloroquine in the treatment of COVID-19. […] However, studies of effectiveness and safety on chloroquine treatment of COVID-19 for the general and geriatric patients are not enough. […] Although there have been reports of successful clinical application of chloroquine in treatment COVID-19，more clinical test data are still needed to prove its effectiveness and safety. | 2020-07-12 |
| 32651961 | This review will focus on the antiviral mechanism, effectiveness and safety, dosage and DDIs of chloroquine, for the purpose to provide evidence-based support for rational use of chloroquine in the treatment of COVID-19. […] However, studies of effectiveness and safety on chloroquine treatment of COVID-19 for the general and geriatric patients are not enough. […] Although there have been reports of successful clinical application of chloroquine in treatment COVID-19，more clinical test data are still needed to prove its effectiveness and safety. | 2020-07-12 |
| 32651961 | This review will focus on the antiviral mechanism, effectiveness and safety, dosage and DDIs of chloroquine, for the purpose to provide evidence-based support for rational use of chloroquine in the treatment of COVID-19. […] However, studies of effectiveness and safety on chloroquine treatment of COVID-19 for the general and geriatric patients are not enough. […] Although there have been reports of successful clinical application of chloroquine in treatment COVID-19，more clinical test data are still needed to prove its effectiveness and safety. | 2020-07-12 |
| 32651961 | This review will focus on the antiviral mechanism, effectiveness and safety, dosage and DDIs of chloroquine, for the purpose to provide evidence-based support for rational use of chloroquine in the treatment of COVID-19. […] However, studies of effectiveness and safety on chloroquine treatment of COVID-19 for the general and geriatric patients are not enough. […] Although there have been reports of successful clinical application of chloroquine in treatment COVID-19，more clinical test data are still needed to prove its effectiveness and safety. | 2020-07-12 |
| 32651961 | This review will focus on the antiviral mechanism, effectiveness and safety, dosage and DDIs of chloroquine, for the purpose to provide evidence-based support for rational use of chloroquine in the treatment of COVID-19. […] However, studies of effectiveness and safety on chloroquine treatment of COVID-19 for the general and geriatric patients are not enough. […] Although there have been reports of successful clinical application of chloroquine in treatment COVID-19，more clinical test data are still needed to prove its effectiveness and safety. | 2020-07-12 |
| 32651961 | This review will focus on the antiviral mechanism, effectiveness and safety, dosage and DDIs of chloroquine, for the purpose to provide evidence-based support for rational use of chloroquine in the treatment of COVID-19. […] However, studies of effectiveness and safety on chloroquine treatment of COVID-19 for the general and geriatric patients are not enough. […] Although there have been reports of successful clinical application of chloroquine in treatment COVID-19，more clinical test data are still needed to prove its effectiveness and safety. | 2020-07-12 |
| 32651961 | This review will focus on the antiviral mechanism, effectiveness and safety, dosage and DDIs of chloroquine, for the purpose to provide evidence-based support for rational use of chloroquine in the treatment of COVID-19. […] However, studies of effectiveness and safety on chloroquine treatment of COVID-19 for the general and geriatric patients are not enough. […] Although there have been reports of successful clinical application of chloroquine in treatment COVID-19，more clinical test data are still needed to prove its effectiveness and safety. | 2020-07-12 |
| 32651961 | This review will focus on the antiviral mechanism, effectiveness and safety, dosage and DDIs of chloroquine, for the purpose to provide evidence-based support for rational use of chloroquine in the treatment of COVID-19. […] However, studies of effectiveness and safety on chloroquine treatment of COVID-19 for the general and geriatric patients are not enough. […] Although there have been reports of successful clinical application of chloroquine in treatment COVID-19，more clinical test data are still needed to prove its effectiveness and safety. | 2020-07-12 |
| 32651961 | This review will focus on the antiviral mechanism, effectiveness and safety, dosage and DDIs of chloroquine, for the purpose to provide evidence-based support for rational use of chloroquine in the treatment of COVID-19. […] However, studies of effectiveness and safety on chloroquine treatment of COVID-19 for the general and geriatric patients are not enough. […] Although there have been reports of successful clinical application of chloroquine in treatment COVID-19，more clinical test data are still needed to prove its effectiveness and safety. | 2020-07-12 |
| 32651961 | This review will focus on the antiviral mechanism, effectiveness and safety, dosage and DDIs of chloroquine, for the purpose to provide evidence-based support for rational use of chloroquine in the treatment of COVID-19. […] However, studies of effectiveness and safety on chloroquine treatment of COVID-19 for the general and geriatric patients are not enough. […] Although there have been reports of successful clinical application of chloroquine in treatment COVID-19，more clinical test data are still needed to prove its effectiveness and safety. | 2020-07-12 |
| 32651961 | This review will focus on the antiviral mechanism, effectiveness and safety, dosage and DDIs of chloroquine, for the purpose to provide evidence-based support for rational use of chloroquine in the treatment of COVID-19. […] However, studies of effectiveness and safety on chloroquine treatment of COVID-19 for the general and geriatric patients are not enough. […] Although there have been reports of successful clinical application of chloroquine in treatment COVID-19，more clinical test data are still needed to prove its effectiveness and safety. | 2020-07-12 |
| 32651961 | This review will focus on the antiviral mechanism, effectiveness and safety, dosage and DDIs of chloroquine, for the purpose to provide evidence-based support for rational use of chloroquine in the treatment of COVID-19. […] However, studies of effectiveness and safety on chloroquine treatment of COVID-19 for the general and geriatric patients are not enough. […] Although there have been reports of successful clinical application of chloroquine in treatment COVID-19，more clinical test data are still needed to prove its effectiveness and safety. | 2020-07-12 |
| 32651961 | This review will focus on the antiviral mechanism, effectiveness and safety, dosage and DDIs of chloroquine, for the purpose to provide evidence-based support for rational use of chloroquine in the treatment of COVID-19. […] However, studies of effectiveness and safety on chloroquine treatment of COVID-19 for the general and geriatric patients are not enough. […] Although there have been reports of successful clinical application of chloroquine in treatment COVID-19，more clinical test data are still needed to prove its effectiveness and safety. | 2020-07-12 |
| 32651961 | This review will focus on the antiviral mechanism, effectiveness and safety, dosage and DDIs of chloroquine, for the purpose to provide evidence-based support for rational use of chloroquine in the treatment of COVID-19. […] However, studies of effectiveness and safety on chloroquine treatment of COVID-19 for the general and geriatric patients are not enough. […] Although there have been reports of successful clinical application of chloroquine in treatment COVID-19，more clinical test data are still needed to prove its effectiveness and safety. | 2020-07-12 |
| 32651961 | This review will focus on the antiviral mechanism, effectiveness and safety, dosage and DDIs of chloroquine, for the purpose to provide evidence-based support for rational use of chloroquine in the treatment of COVID-19. […] However, studies of effectiveness and safety on chloroquine treatment of COVID-19 for the general and geriatric patients are not enough. […] Although there have been reports of successful clinical application of chloroquine in treatment COVID-19，more clinical test data are still needed to prove its effectiveness and safety. | 2020-07-12 |
| 32651961 | This review will focus on the antiviral mechanism, effectiveness and safety, dosage and DDIs of chloroquine, for the purpose to provide evidence-based support for rational use of chloroquine in the treatment of COVID-19. […] However, studies of effectiveness and safety on chloroquine treatment of COVID-19 for the general and geriatric patients are not enough. […] Although there have been reports of successful clinical application of chloroquine in treatment COVID-19，more clinical test data are still needed to prove its effectiveness and safety. | 2020-07-12 |
| 32651961 | This review will focus on the antiviral mechanism, effectiveness and safety, dosage and DDIs of chloroquine, for the purpose to provide evidence-based support for rational use of chloroquine in the treatment of COVID-19. […] However, studies of effectiveness and safety on chloroquine treatment of COVID-19 for the general and geriatric patients are not enough. […] Although there have been reports of successful clinical application of chloroquine in treatment COVID-19，more clinical test data are still needed to prove its effectiveness and safety. | 2020-07-12 |
| 32651961 | This review will focus on the antiviral mechanism, effectiveness and safety, dosage and DDIs of chloroquine, for the purpose to provide evidence-based support for rational use of chloroquine in the treatment of COVID-19. […] However, studies of effectiveness and safety on chloroquine treatment of COVID-19 for the general and geriatric patients are not enough. […] Although there have been reports of successful clinical application of chloroquine in treatment COVID-19，more clinical test data are still needed to prove its effectiveness and safety. | 2020-07-12 |
| 32651961 | This review will focus on the antiviral mechanism, effectiveness and safety, dosage and DDIs of chloroquine, for the purpose to provide evidence-based support for rational use of chloroquine in the treatment of COVID-19. […] However, studies of effectiveness and safety on chloroquine treatment of COVID-19 for the general and geriatric patients are not enough. […] Although there have been reports of successful clinical application of chloroquine in treatment COVID-19，more clinical test data are still needed to prove its effectiveness and safety. | 2020-07-12 |
| 32651961 | This review will focus on the antiviral mechanism, effectiveness and safety, dosage and DDIs of chloroquine, for the purpose to provide evidence-based support for rational use of chloroquine in the treatment of COVID-19. […] However, studies of effectiveness and safety on chloroquine treatment of COVID-19 for the general and geriatric patients are not enough. […] Although there have been reports of successful clinical application of chloroquine in treatment COVID-19，more clinical test data are still needed to prove its effectiveness and safety. | 2020-07-12 |
| 32651961 | This review will focus on the antiviral mechanism, effectiveness and safety, dosage and DDIs of chloroquine, for the purpose to provide evidence-based support for rational use of chloroquine in the treatment of COVID-19. […] However, studies of effectiveness and safety on chloroquine treatment of COVID-19 for the general and geriatric patients are not enough. […] Although there have been reports of successful clinical application of chloroquine in treatment COVID-19，more clinical test data are still needed to prove its effectiveness and safety. | 2020-07-12 |
| 32651961 | This review will focus on the antiviral mechanism, effectiveness and safety, dosage and DDIs of chloroquine, for the purpose to provide evidence-based support for rational use of chloroquine in the treatment of COVID-19. […] However, studies of effectiveness and safety on chloroquine treatment of COVID-19 for the general and geriatric patients are not enough. […] Although there have been reports of successful clinical application of chloroquine in treatment COVID-19，more clinical test data are still needed to prove its effectiveness and safety. | 2020-07-12 |
| 32651997 | Severe COVID-19 can manifest in rapid decompensation and respiratory failure with elevated inflammatory markers, consistent with cytokine release syndrome for which IL-6 blockade is approved treatment. | 2020-07-12 |
| 32652164 | As the novel SARS-CoV-2 pandemic occurred, no specific treatment was yet available. […] This retrospective, single-center analysis included all the patients consecutively admitted to our Hospital with severe or critical COVID-19 who started TCZ treatment from March 13th to April 03rd, 2020. […] Some of the tocilizumab doses used in the subjects included in this analysis were provided by the “Multicenter study on the efficacy and tolerability of tocilizumab in the treatment of patients with COVID-19 pneumonia” (EudraCT Number: 2020-001110-38) supported by the Italian National Agency for Drugs (AIFA). | 2020-07-12 |
| 32652214 | Viral viability was determined after treatment with various disinfectants and pH solutions at room temperature (20-25oC). | 2020-07-12 |
| 32652308 | Existing HCC risk stratification models should be utilized to prioritize imaging resources to those patients at highest risk of incident HCC and recurrence following therapy though surveillance can likely continue as before in settings where COVID-19 prevalence is low and adequate protections are in place. […] Waitlisted patients who will benefit from urgent LT should be prioritized for surveillance whereas it would be reasonable to extend surveillance interval by a short period in HCC patients with lower risk tumor features and those more than 2 years since their last treatment. […] For patients eligible for systemic therapy, the treatment regimen should be dictated by the risk of COVID-19 associated with route of administration, monitoring and treatment of adverse events, within the context of relative treatment efficacy. | 2020-07-12 |
| 32652357 | Although there is no current evidence showing that coronaviruses can be transmitted through contaminated drinking water, there is a growing concern on the impact of the current pandemic wave on underprivileged societies because of their poor wastewater treatment infrastructures, overpopulation, and outbreak management strategies. | 2020-07-12 |
| 32652385 | Derived from the self-medication hypothesis, this research explored how perceived threat and psychological distress related to the COVID-19 pandemic are associated with drinking behavior among an American sample of adults. | 2020-07-12 |
| 32652443 | We investigated the medical records on the number of cancer diagnosis, cancer surgery, radiation therapy and scheduled chemotherapy conducted in Korea University Anam Hospital from January 1 to April 30, 2019 and from the same period in 2020. […] Of all diagnoses, 1694 cancer diagnoses were made in the study period of 2019, and 1445 diagnoses in 2020 (decreased by 14.7%); the cancer surgery performed 830 and 800 cases; the set-up for radiation therapy decreased from 185 to 140 cases; the number of systemic chemotherapies for metastatic cancer patients treated in department of medical oncology increased from 2555 to 2878 cases. | 2020-07-12 |
| 32652454 | Chest CT plays an important role in the diagnosis and monitoring treatment response of this disease. | 2020-07-12 |
| 32652521 | Specific SARS-CoV-2 treatment seems unnecessary for most children. | 2020-07-12 |
| 32652713 | Cardiac-specific biomarkers provide a useful prognostic tool in helping identify patients with the severe disease early and allowing for escalation of treatment in a timely fashion. | 2020-07-12 |
| 32652782 | During the COVID-19 pandemic caused by the SARS-CoV-2 virus, patients with BC still require timely treatment and follow-up; however, hospitals are overwhelmed with infected patients and, if exposed, patients with BC are at higher risk for infection and serious complications if infected. […] Thus, health care providers need to evaluate each BC treatment and in-hospital visit to minimize pandemic-associated risks while maintaining adequate treatment efficacy. […] Here we present a set of guidelines regarding available options for BC patient management and treatment by BC subtype in the context of the COVID-19 pandemic. […] IMPLICATIONS FOR PRACTICE: This work presents a set of guidelines regarding available options for breast cancer (BC) patient management and treatment by BC subtype in the context of the COVID-19 pandemic. | 2020-07-12 |
| 32652862 | The preparedness plan was activated March 23, 2020, and data were collected on treatment planning and chart checking efficiency for 6 weeks. […] Efficiency of treatment planning and chart checking was slightly better than a comparable 6-week interval in 2019. | 2020-07-12 |
| 32652912 | It appears that existing infection with HIV or receiving antiretroviral treatment (ART) might reduce the susceptibility to the infection with SARS-CoV-2 or decrease the severity of the infection acquired. | 2020-07-13 |
| 32652915 | Despite many groups engaged in studying the newly emerged virus and searching for the treatment, the understanding of the SARS-CoV2 target ligand interactions represents a key challenge. […] Several studies are being conducted to identify potential treatment. […] Furthermore, given the demonstrated results of thymoquinone, we can conclude that it may be considered as an effective or adjuvant treatment for SARS CoV2 infection. | 2020-07-13 |
| 32653015 | To date, no specific treatment has convincingly demonstrated its efficacy. […] The primary outcomes were treatment escalation (intubation, extra-corporeal membrane oxygenation support, or renal replacement therapy) after day 1 until day 28. […] Secondary outcomes included ventilator-free days at day 28, mortality at day 14 and day 28, treatment safety issues and changes in respiratory tracts, and plasma viral load (as estimated by cycle threshold value) between admission and day 7. […] Treatment escalation occurred in 9 (41%), 10 (50%), and 15 (39%) patients who received standard of care only, standard of care and lopinavir/ritonavir, and standard of care and hydroxychloroquine, respectively (p = 0.567). […] In critically ill patients admitted for SARS-CoV-2-related pneumonia, no difference was found between hydroxychloroquine or lopinavir/ritonavir as compared to standard of care only on the proportion of patients who needed treatment escalation at day 28. | 2020-07-13 |
| 32653054 | In April, 2020, clinicians in the UK observed a cluster of children with unexplained inflammation requiring admission to paediatric intensive care units (PICUs). | 2020-07-13 |
| 32653111 | Forty EEGs were reviewed in 36 COVID-19 patients, 18 in intensive care units (ICU) and 22 in medicine units. | 2020-07-13 |
| 32653160 | The PaO2:FiO2 ratio and minimum SpO2 were lower in the death group, and a higher proportion of these patients received noninvasive mechanical ventilation, invasive mechanical ventilation and extracorporeal membrane oxygenation treatment. […] For such patients, comprehensive treatment should be performed as soon as possible to improve the prognosis and reduce mortality. | 2020-07-13 |
| 32653224 | BCG can be uses as a prophylactic treatment until the availability of the COVID-19 vaccine. | 2020-07-13 |
| 32653423 | More attention should be paid to the prevention and treatment for diabetic patients, especially those who require insulin therapy. | 2020-07-13 |
| 32653518 | Then the therapeutic steps and potential vaccine candidates have been described in a hope to provide a better prospective of effective treatment and preventive strategies to the novel SARS-CoV in near future. | 2020-07-13 |
| 32653520 | Based on combinatorial molecular simulation analysis, doxycycline and minocycline were selected as potent inhibitor against SARS-CoV-2 Mpro which can used in combinational therapy against SARS-CoV-2 infection. | 2020-07-13 |
| 32653522 | Thus, the authors aim to provide an opportunity for the researchers to consider RAAS system to be a significant element in development of suitable treatment regime for COVID-19 pandemic. | 2020-07-13 |
| 32653618 | However, surveillance, prevention and treatment must be strictly evidence-based and not dictated by fear. | 2020-07-13 |
| 32653627 | Individuals affected by cancer are more susceptible to infections owing to coexisting chronic diseases (cardiovascular, pulmonary, and diabetes), overall poor health status, and systemic immunosuppressive states caused by both cancer and the anticancer treatment. | 2020-07-13 |
| 32653649 | Traditional Chinese medicine (TCM) has fully engaged and played an essential role in the prevention and treatment of Coronavirus Disease 2019 (COVID-19). | 2020-07-13 |
| 32653701 | To address this concern, a specific multidisciplinary working group was settled by the Italian National Institute of Health (ISS) during the COVID-19 emergency, in order to establish guidelines related to solid waste collection, delivering, withdrawal, transport, treatment and disposal. […] Incineration, sterilization and properly managed landfills were identified as the facilities to be preferentially adopted for the treatment of this kind of waste, considering the main inactivation strategies of SARS-CoV-2 (e.g. treatment length > 9 days and temperature > 70 °C for more than 5 min). | 2020-07-13 |
| 32653736 | We wonder why surfactants are still not tried for prophylaxis or therapy against COVID-19? […] Therefore, we postulate that surfactant-based prophylaxis and therapy would be promising. […] We believe that our hypothesis would stimulate debate or new research exploring the possibility of surfactant-based prophylaxis and therapy against COVID-19. | 2020-07-13 |
| 32653775 | While the challenge of integration is not unique to oncology, the organisation of cancer care and its linkages to palliative care and to global health may allow it to be a demonstration model for how the problem of integration can be addressed. […] Before the pandemic, the large majority of individuals with cancer in need of palliative care in low- and middle-income countries and the poor or marginalised in high-income countries were denied access. | 2020-07-13 |
| 32653804 | Management of idiopathic Central Nervous system inflammatory disorders (iCNSID) such as Multiple sclerosis, Neuromyelitis optica and its spectrum disorders and related conditions during this pandemic needs to be addressed with affirmative and sustainable strategies in order to prevent disease related risks, medication related complications and possible COVID-19 disease associated effects. […] In this retrospective study with longitudinal follow-up, we describe stratification of patients for face to face versus virtual visits in the absence of formal teleneurology, stratification of patients for treatment according to disease activity, rescheduling, deferring initiation or extending treatment intervals of certain disease modifying therapies(DMT’s) or immunosuppressants(IS), especially those producing lymphocyte depletion in MS and the continuation of IS in patients with NMO/NMOSD. | 2020-07-13 |
| 32653890 | This paper reviews the different imaging modalities used in the diagnosis and treatment process of COVID-19, such as chest radiography, computerized tomography (CT) scan, ultrasound examination, and positron emission tomography (PET/CT) scan. […] In the absence of vaccines and treatments for COVID-19, prompt diagnosis and appropriate treatment are essential. | 2020-07-13 |
| 32653986 | The SARS-CoV-2 induced infection is associated with higher rates of thrombotic events of the extracorporeal system during V-V ECMO therapy. | 2020-07-13 |
| 32654006 | Despite considerable advances in our knowledge regarding the pathophysiology of ARDS, insights into the biologic mechanisms of lung injury and repair, and advances in supportive care, particularly ventilatory management, there remains no effective pharmacological therapy for this syndrome. | 2020-07-13 |
| 32654018 | Elective surgeries have been canceled or delayed in order to reallocate resources to the treatment of COVID-19 patients. […] Laparoscopy was still the preferred treatment for surgical emergencies, but a trend towards conservative treatment of acute appendicitis and acute cholecystitis was shown. | 2020-07-13 |
| 32654021 | We characterized the economic, mental health, HIV prevention and HIV treatment impacts of COVID-19 and the COVID-19 response, and examined whether sub-groups of our study population are disproportionately impacted by COVID-19. […] Many gay men and other MSM not only reported economic and mental health consequences, but also interruptions to HIV prevention and testing, and HIV care and treatment services. | 2020-07-13 |
| 32654049 | The aim of this study was investigation of COVID-19 disease and its outcome in cancer patients who needed treatment, in a 90-day period. […] Cancer patient who required treatment, were evaluated for potential COVID-19 infection in a 90-day period, starting from beginning of this epidemic in Iran, January, to April 19, 2020. […] For treatment of solid tumor patients, if they did not have symptoms related to COVID-19, just chest X-ray was requested. […] Patients with cancer who need treatment can be treated by taking some measures. […] These measures include observing individual and collective protection principles in patients and health-care personnel, increasing patients’ awareness particularly about self-care behavior, performing a COVID-19 test, and taking a chest X-ray, before the treatment starts. | 2020-07-13 |
| 32654082 | Isolated heparin therapy may not be sufficient to combat thrombosis in this disease. […] • Patients with COVID-19 at high risk for thrombosis should be put on high dose heparin therapy. | 2020-07-13 |
| 32654098 | Hydroxychloroquine, chloroquine, and azithromycin have been used for treatment of COVID-19, but may cause QT prolongation. […] We examined electrocardiograms (ECG) pre/post-medication initiation to evaluate QTc, HR, QRS duration, and presence of other arrhythmias. […] The median time from the first dose of any treatment to post-medication ECG was 2 days (IQR: 1-3). […] The number of patients whose QTc > 500 ms was significantly increased after treatment (16.2% vs. […] Our findings suggest that any harm is unlikely to outweigh potential benefits of treatment. | 2020-07-13 |
| 32654134 | However, COVID-19 is a serious disease that currently has no effective treatment or vaccine. […] On the other hand, in the absence of any proven treatment or vaccine to combat COVID-19, prevention is the best available strategy and it is probably not reasonable to suggest avoid wearing face masks in PWE under any circumstances. | 2020-07-13 |
| 32654210 | Therefore, the use of echocardiography, according to the safety local protocols and ensuring the use of personal protective equipment, could be useful firstly to discriminate between primary cardiac disease or COVID-19-related myocardial damage, and then for assessing and monitoring COVID-19 cardiovascular complications: acute myocarditis and arrhythmias, acute heart failure, sepsis-induced myocardial impairment, and right ventricular failure derived from treatment with high-pressure mechanical ventilation. | 2020-07-13 |
| 32654332 | Acute kidney injury requiring renal replacement therapy occurred in 20% of SOTr compared to 4% of controls (OR 6 CI [1.64-22] P = .007). | 2020-07-13 |
| 32654357 | Treatment with cyclosporine was associated with better clinical outcome. | 2020-07-13 |
| 32654378 | Susceptibility to viral infection, development of immunity, response to treatment and patient clinical outcomes are all under the control of heritable factors in the host. | 2020-07-13 |
| 32654387 | Few data are available in these species; we first listed forty-six possible drivers of emergence of COVID-19 in pets, regrouped in eight domains (i.e. pathogen/disease characteristics, spatial-temporal distance of outbreaks, ability to monitor, disease treatment and control, characteristics of pets, changes in climate conditions, wildlife interface, human activity, and economic and trade activities). […] Five drivers were ranked with the highest probability to play a key role in the emergence of COVID-19 in pets: availability and quality of diagnostic tools, human density close to pets, ability of preventive/control measures to avoid the disease introduction or spread in a country (except treatment, vaccination and reservoir(s) control), current species specificity of the disease-causing agent and current knowledge on the pathogen. | 2020-07-13 |
| 32654428 | This study aims to review the studies and researches of COVID-19 among people living with HIV, covering the impacts of COVID-19 on their disease progression, HIV-related medical services, HIV epidemics, and measures on relieving the above-mentioned impacts, which might provide references for targeted scientific research and prevention practice of COVID-19 in HIV population, and optimizing prevention and treatment services in the context of this pandemic. | 2020-07-13 |
| 32654433 | This perspective looks at the impact of COVID-19 in South America and argues that the health critical care systems of these countries are particularly vulnerable due to the underestimation of the number of cases currently confirmed and the strong need for treatment of these patients in intensive care units (ICUs). | 2020-07-14 |
| 32654434 | While these “flattening the curve” initiatives are showing signs of impeding the potential surge in COVID-19 cases, it is not known whether these measures alleviate the burden placed on intensive care units. | 2020-07-14 |
| 32654489 | Drug repurposing offers a promising route for the development of prevention and treatment strategies for COVID-19. | 2020-07-14 |
| 32654514 | Although it is generally believed that QTc changes almost exclusively result from concomitant treatment with QT-prolonging antimicrobials, direct effects of inflammatory cytokines on ventricular repolarization are increasingly recognized. […] During acute infections, systemic inflammation rapidly induces cytokine-mediated ventricular electrical remodeling and significant QTc prolongation, regardless concomitant antimicrobial therapy. […] It is timely and warranted to transpose these findings to the current coronavirus disease 2019 (COVID-19) pandemic, in which both increased amounts of circulating cytokines and cardiac arrhythmias are demonstrated along with a frequent concomitant treatment with several QT-prolonging drugs. | 2020-07-14 |
| 32654555 | Patients with hypertension were further divided into the RAAS inhibitor group (n=41) and non-RAAS inhibitor group (n=241) according to their medication history. […] In addition, hypertensive patients with a history of RAAS inhibitor treatment had lower levels of C-reactive protein and higher levels of CD4+ cells. | 2020-07-14 |
| 32654557 | When comparing exposure to RAAS inhibitors and nonexposure to RAAS inhibitors for intensive care unit admission, high-flow oxygen therapy, and death, the adjusted odds ratios (95% CIs) were 1.515 (0.402-5.701), 0.663 (0.272-1.619), and 1.363 (0.513-3.662), respectively. | 2020-07-14 |
| 32654634 | With new findings suggesting that COVID-19 is a systemic disease, impacting the respiratory system and beyond in some individuals, we need new molecular targets for therapeutics innovation more than ever. | 2020-07-14 |
| 32654907 | Some reports suggested a relation between the Bacillus Calmette-Guérin (BCG) vaccine and the malaria treatment to the prevention of SARS-CoV-2 infection. | 2020-07-14 |
| 32654921 | Automatic recording was made of demographic variables, severity parameters, laboratory data, assisted ventilation (HFO: high-flow oxygen therapy and IMV: invasive mechanical ventilation), oxygenation (PaO2, PaO2/FiO2) and complications. […] High-flow oxygen therapy was used in 62.7% of the patients, with failure in 85%. | 2020-07-14 |
| 32654931 | The Food and Drug Administration has recently approved the off-label use of hydroxychloroquine (HCQ) for the treatment of coronavirus disease 2019 (COVID-19) infections. […] However, a recent study not only failed to demonstrate HCQ efficacy but also documented a serious side effect of COVID-19 therapy with HCQ: QT prolongation and secondary arrhythmia. […] HCQ has been used as an off-label drug and deemed safe and effective for the treatment of oral lesions, such as Sjogren syndrome (SS), chronic ulcerative stomatitis (CUS), and oral lichen planus (OLP). […] Because HCQ may be appropriately used for the off-label treatment of SS, CUS, and OLP, relevant safety concerns regarding HCQ therapy with regard to dosage, drug-to-drug interactions, and QT prolongation and secondary arrhythmia are discussed here. | 2020-07-14 |
| 32654963 | Compared with patients in the highest RVLS tertile, those in the lowest tertile were more likely to have higher heart rate; elevated levels of D-dimer and C-reactive protein; more high-flow oxygen and invasive mechanical ventilation therapy; higher incidence of acute heart injury, acute respiratory distress syndrome, and deep vein thrombosis; and higher mortality. | 2020-07-14 |
| 32654986 | In the current scenario, it is not clear how patients with myeloproliferative neoplasms (including chronic myelogenous leukemia) should be managed, considering the risk of therapy, the need for social distancing and the risk of untimely therapy discontinuation of delay. | 2020-07-14 |
| 32655013 | From 26 studies (n=5497), the pooled incidence of AKI in patients with COVID-19 was 8.4% (95% CI 6.0% to 11.7%) with a pooled incidence of renal replacement therapy of 3.6% (95% CI 1.8% to 7.1%). | 2020-07-14 |
| 32655019 | Treatment of coronavirus disease 2019 (COVID-19) among patients with CKD requires special pharmacotherapy considerations that are reviewed here. […] Literature review was done for several pharmacotherapy aspects in CKD patients including selection and modification of COVID-19 treatment, drug interactions, nephrotoxicity of drugs that are used for treatment of COVID-19 and potential risks/benefits of routine medications of CKD patients during COVID-19 pandemic. […] Fluid therapy and anticoagulant prophylaxis/ treatment need special attention in CKD patients with COVID-19. | 2020-07-14 |
| 32655489 | Treatment of these symptoms is addressed with paracetamol being recommended as a possible, but not conclusive, treatment to some CNS symptoms. […] Possible treatment options for these symptoms are then addressed as a major limitation, as anecdotal, and not conclusive evidence can be made. | 2020-07-14 |
| 32655577 | Due to the increasing number of patients experiencing a severe outcome, global scientific efforts are ongoing to find the most appropriate treatment. […] The usefulness of specific anti-rheumatic drugs came out as a promising treatment option together with antiviral drugs, anticoagulants, and symptomatic and respiratory support. | 2020-07-14 |
| 32655582 | Here we review the literature that describes the pathogenesis of severe COVID-19 and NLRP3 activation and describe an important role in targeting this pathway for the treatment of severe COVID-19. | 2020-07-14 |
| 32655654 | It is hoped that existing antivirals including remdesivir and lopinavir-ritonavir might have roles in the treatment of COVID-19, but results from trials thus far have not been promising. […] Immunomodulatory treatments and biologics are also being actively explored as therapeutics for COVID-19. | 2020-07-14 |
| 32655724 | If they become positive for SARS-CoV-2 RNA or COVID-19, their biologic therapy should be either delayed or on hold temporarily. | 2020-07-14 |
| 32655741 | Extracorporeal blood purification is proposed as an adjuvant therapy for sepsis and aims at controlling the dysregulated autoimmune system. […] We describe our experience in treating COVID-19 patients with the oXiris® hemofilter which adsorbs both cytokines and endotoxins, provides renal replacement therapy and has anti-thrombogenic properties. | 2020-07-14 |
| 32655742 | Anticoagulation treatment may cause life-threatening bleeding complications such as retroperitoneal hemorrhage. […] Anticoagulation therapy, while indicated in COVID-19 patients, has its own challenges and guidelines describing dosages and indications in this disease are lacking. […] Rare bleeding complications such as psoas hematoma should be kept in mind in patients who become hemodynamically unstable, warranting prompt imaging for diagnosis and treatment with arterial embolization, thus eliminating need of surgical intervention. | 2020-07-14 |
| 32655846 | The collected information may suggest that psoriasis, biotechnologically treated or not, cannot promote or aggravate the clinical trend of the SARS-CoV-2 infection, hence stopping systemic therapy in negative or clinically free SARS-CoV-2 patients is not recommended in general. | 2020-07-14 |
| 32655856 | Early detection and treatment of right ventricle dysfunction may lead to decreased mortality and improved patient outcomes in corona virus disease of 2019. | 2020-07-14 |
| 32655899 | Convalescent plasma therapy holds promise as a transient treatment for COVID-19. […] Great care must be taken to prevent plasma therapy from fueling HIV epidemics in the developing world. | 2020-07-14 |
| 32656006 | We conducted a systematic review and included 16 case reports to summarize the transmission and pathology of 2019-nCoV, and clinical presentation, laboratory and imaging findings, and treatment in 2019-nCoV pneumonia. […] Although there is no definitive treatment for 2019-nCoV pneumonia so far, some antiviral drugs have shown promising results. […] Nonetheless, we need more randomized clinical trials (RCTs) and treatment guidelines for developing effective management of the 2019-nCoV and improve patient outcomes by reducing mortality in high-risk patients. | 2020-07-14 |
| 32656044 | We present the cases of three patients with severe, life-threatening coronavirus disease 2019 (COVID-19) who had failed to achieve substantial improvement on intial treatment. […] They subsequently received pulse therapy with methylprednisolone [1,000 mg/day intravenously (IV) for three consecutive days] and IV immunoglobulin (20 g/day). […] This treatment regimen was associated with a prompt resolution of respiratory failure, elimination of clinical manifestations of the cytokine release syndrome (CRS), and reversal of pulmonary CT changes. […] The treatment was generally safe and well-tolerated. […] Further randomized controlled trials are required to better understand the efficacy and safety of high-dose methylprednisolone and IV immunoglobulin, separately or in combination with each other, in the treatment of severe, life-threatening COVID-19. | 2020-07-14 |
| 32656050 | This case emphasizes the importance of continued investigation regarding diagnosis and treatment of COVID-19 and its related symptoms. | 2020-07-14 |
| 32656087 | However, ovarian tissue cryopreservation is an additional FP practice suitable when an anti-cancer treatment is urgently required, whereas, for male patients, sperm cryopreservation is a simple and well-adopted procedure. | 2020-07-14 |
| 32656221 | During treatment, 2 patients died due to organ failure. | 2020-07-14 |
| 32656222 | Demographics, clinical characteristics, treatments, and treatment outcomes between patients with or without liver injury were compared within each group. […] Multivariable regression showed that the number of concomitant medications (odds ratio [OR]: 1.12, 95% confidence interval [CI]: 1.05-1.21) and the combination treatment of lopinavir/ritonavir and arbidol (OR: 3.58, 95% CI: 1.44-9.52) were risk factors for liver injury in non-critically ill patients. | 2020-07-14 |
| 32656223 | After treatment, all patients had two consecutively negative nucleic acid tests and were discharged from hospital. […] The positive patient was immediately readmitted and received a new round of treatment. | 2020-07-14 |
| 32656306 | Containment of the infection of this virus is the only available measure to control the disease as no vaccine or specific antiviral treatment is available. | 2020-07-14 |
| 32656310 | and (4) study the possible drugs/treatment plans against COVID-19. […] (4) Researchers’ claim that nutrition and immunity enhancers and treatment plans such as arbidol, lopinavir/ritonavir, convalescent plasma and mesenchymal stem cells and drugs including remdesivir, hydroxychloroquine, azithromycin and favipiravir are effective against COVID-19. […] This complied report serves as guide to help the administrators, researchers and the medical officers to adopt recommended intervention strategies and the optimal treatment/drug against COVID-19. | 2020-07-14 |
| 32656311 | Although few molecules have been tested and shown some efficacy against SARS-CoV-2 in humans but a safe and cost-effective attachment inhibitors are still required for the treatment of COVID-19. | 2020-07-14 |
| 32656501 | We introduce a website to be used by The Bill & Melinda Gates Foundation, Wellcome Trust, and other funders of the COVID Therapeutics Accelerator that accept proposals for future clinical research. | 2020-07-14 |
| 32656589 | It also argues that a negative test result on symptomatic individuals should not be over-relied upon for allowing the treatment to proceed. | 2020-07-14 |
| 32656638 | The cases were divided into regular group, severe group and critically ill group according to the sixth edition scheme for COVID-19 diagnosis and treatment of China. | 2020-07-14 |
| 32656663 | Postponing cancer treatment without consideration of its implications could cost more lives than can be saved. […] This article provides general guidance on supporting curative treatment strategies in vulvar cancer patients. […] At our institution, a vulvar cancer multidisciplinary team (Vul.Can MDT) of specialists is responsible for personalized treatment of this disease. […] In brief, an accurate remote and in person triage must be provided routinely and patients submitted to specific diagnostic tests prior to every major treatment or procedure (surgery, RT, and CT) or in case of suspicion for COVID-19 syndrome. […] The team produced two types of recommendations concerning: (1) safety regulations of care pathways, patients and health care providers, (2) personalized treatment strategies. […] We present a protocol that can be applied in clinical practice: the flowcharts provided, include the modulation of treatment intensity designed for surgical procedures and radiation, stratified for FIGO stage of disease and intention. | 2020-07-14 |
| 32656794 | There is concern that reduced access to diagnosis and treatment can also lead to increased morbidity in patients with liver diseases and we may witness a delayed surge of hospitalizations related to decompensated liver disease after the COVID-19 pandemic has receded. | 2020-07-14 |
| 32656888 | Epidemiological, clinical, laboratory, and treatment data were collected and explored the risk factors associated with in-hospital death. | 2020-07-14 |
| 32656985 | In a minority of patients, SARS-CoV-2 manifests with a severe acute respiratory illness and currently there is insufficient data regarding the virulence of COVID-19 in inflammatory bowel disease patients taking immunosuppressive therapy. | 2020-07-14 |
| 32657000 | The study concludes that the COVID-19 infodemic is full of false claims, half backed conspiracy theories and pseudoscientific therapies, regarding the diagnosis, treatment, prevention, origin and spread of the virus. | 2020-07-14 |
| 32657091 | He was receiving mechanical ventilation and veno-venous extracorporeal membrane oxygenation treatment for severe hypoxia. […] Active surveillance and intensive treatment strategy are important for saving lives of COVID-19 patients with acute myocardial infarction. | 2020-07-14 |
| 32657186 | Thirty-one percent of the patients were admitted to intensive care units (ICUs), and 16% required intubation. […] No substantial conclusions could be drawn on the efficacy of any particular treatment. | 2020-07-14 |
| 32657436 | Moreover, since these Basidiomycota also have anti-inflammatory properties, they may be suited for treatment of the severe lung inflammation that often follows COVID-19 infection. | 2020-07-14 |
| 32657483 | Although there are a lot of agents under investigation, there is no approved agent for the prevention or treatment of the COVID-19 yet. […] Treatment of patients remains mainly supportive as well as compassionate use of the agents under investigation. […] In this review, we aimed to update knowledge about pathogenesis, clinical features and pharmacological treatment of COVID-19 and review the potential beneficial effects of ancient antioxidant, anti-inflammatory and immunomodulatory molecule melatonin for prevention and treatment of COVID-19. | 2020-07-14 |
| 32657527 | All had HIV viral load <200 copies/mL and were on antiretroviral therapy with CD4 count range 87 to 1441 cells/µL. […] More data are needed as we develop our understanding of how HIV and antiretroviral therapy are affected by or have an impact on this pandemic. | 2020-07-14 |
| 32657540 | Management of COVID-19 in kidney transplant recipients should include treatment of the infection, regulation of immunosuppression, and supportive therapy. […] The frequency of previous induction and rejection therapy was significantly higher in the group with severe pneumonia compared to the moderate pneumonia group. […] Induction therapy with lymphocyte-depleting agents should be carefully avoided in kidney transplant recipients during the pandemic period. | 2020-07-14 |
| 32657586 | However, the complexities of COVID-19 are such that fuller definitions of patient status, trajectory, sequelae, and responses to therapy are now required. | 2020-07-14 |
| 32657601 | Treatment of the infection is still not available; however, antivirals are under clinical trials. | 2020-07-14 |
| 32657643 | The results pointed out here suggest new potential drugs for therapy to aid the rational drug search against COVID-19. | 2020-07-14 |
| 32657671 | Considering the benefits of smoking cessation in this vulnerable population, the current pandemic should be used as an opportunity to further enforce smoking cessation in mental health facilities and encourage nicotine replacement therapy alongside cessation counseling. | 2020-07-14 |
| 32657810 | The current controversies include quantifying safety outcomes, such as potential delayed or missed injuries, inadequate treatment, and medicolegal claims. | 2020-07-14 |
| 32657818 | Critical elements of a comprehensive rehabilitation treatment plan for those who have been prone positioned, including implementation of preventive strategies, as well as early recognition and treatment of related injuries, will be described. | 2020-07-14 |
| 32657965 | Although clinical outcomes in the treatment of aspergillosis have markedly improved with the availability of newer triazoles, the development of resistance to these antifungals, especially in Aspergillus fumigatus, is a growing concern. […] The purpose of this review is to provide an update on azole resistance mechanisms and their epidemiology in A. fumigatus, the clinical implications of azole resistance, and to discuss future treatment options against azole-resistant aspergillosis. […] Although current treatment options are limited, newer therapies are in clinical development. […] While treatment options are currently limited, new agents under clinical development may offer hope. | 2020-07-14 |
| 32658005 | In both conditions, clinicians may be doubtful regarding the safety of nonsteroidal anti-inflammatory drugs (NSAIDs), corticosteroids, colchicine, and biological agents, such as anti-IL1 agents (e.g. anakinra), that are the mainstay of therapy for pericarditis.For NSAIDs, there is no clear scientific evidence linking ibuprofen and other NSAIDs to worsening of COVID-19; however, it seems prudent to continue them, if necessary to control pericarditis, and on the other hand, to prefer paracetamol for fever and systemic symptoms related to COVID-19. | 2020-07-14 |
| 32658017 | To provide a treatment algorithm for care of COVID-19 positive/suspected hip fractures patients that accounts for their increased risk of morbidity and mortality. […] Patients with COVID-19 symptoms on presentation should have surgery deferred until symptoms improve or resolve and should be reassessed for surgical treatment versus definitive nonoperative treatment with palliative care and/or hospice care. | 2020-07-14 |
| 32658300 | Anti-inflammatory treatment may be considered and discussed with a nephrologist. […] Treatment with ACEi/ARBs should be continued if possible. | 2020-07-14 |
| 32658716 | At the end of March 2020, ivermectin was confirmed as a drug for COVID-19 treatment. | 2020-07-14 |
| 32658735 | To date, no approved treatment regimen or vaccine is available to effectively attenuate or prevent the infection. […] Therefore, collective and multidisciplinary efforts are needed to identify new therapeutics or to explore effectiveness of existing drugs and drug-like small molecules against SARS-CoV-2 for lead identification and repurposing prospects. | 2020-07-14 |
| 32658818 | Regular screening and appropriate treatment of depression are urgently warranted for this population. | 2020-07-14 |
| 32658841 | Convalescent plasma is the only antibody-based therapy available for COVID-19 patients to date. […] EpAbs are easy to manufacture allowing a fast development and scaling up for a treatment. | 2020-07-14 |
| 32658842 | The model used was the “Susceptible-Exposed-Infectious-Recovered” framework which incorporated appropriate compartments relevant to interventions such as quarantine, isolation and treatment. | 2020-07-14 |
| 32658848 | Guidelines on resource allocation, ethics, triage processes with admission and discharge criteria from critical care and palliative care units during the pandemia are here presented. […] The interdisciplinary and multi-society panel that prepared these guidelines represented by bioethicists and specialists linked to the end of life: clinicians, geriatricians, emergentologists, intensivists, and experts in palliative care and cardiopulmonary resuscitation. […] The available information indicates that approximately 80% of people with COVID-19 will develop mild symptoms and will not require hospital care, while 15% will require intermediate or general room care, and the remaining 5% will require assistance in intensive care units. | 2020-07-14 |
| 32658849 | We suggest starting prophylactic anticoagulant therapy for all patients hospitalized with a symptomatic infection with COVID-19, unless contraindicated, with enoxaparin 40 mg SC daily if creatinine clearance is greater than 30 ml/min. | 2020-07-14 |
| 32658857 | Providing easily accessible guidance is a first step but will need cultural change to implement as clinicians start to view telepsychiatry not just as a replacement but as a parallel and complementary form of delivering therapy with its own advantages and benefits as well as restrictions. […] A combination or hybrid approach can be the most successful approach in the new world of mental health post-COVID-19, and guidance will need to expand to encompass the use of telepsychiatry in conjunction with other in-person and digital technologies, and its use across all psychiatric disorders, not just those who are the first to access and engage with remote treatment. | 2020-07-14 |
| 32658879 | Lockdown and self-isolation are to date the only solution to limit the spread of recent outbreak of coronavirus disease (CoViD-19), highlighting the great advantage of home dialysis in a patient otherwise forced to travel from / to the dialysis center to receive this “life-saving” treatment. […] Peritoneal dialysis (PD) represents a type of home dialysis therapy not yet adequately implemented to date, in spite of safe and simple practice, as well as similar dialytic efficiency vs in-center hemodialysis. […] Remote patient monitoring (RPM) systems have been developed in automated PD (APD) cyclers in order to improve the acceptance of this dialysis method, to increase the compliance to the prescribed therapy and to control treatment adequacy. […] In this review we assess the potential advantages of RPM in APD, that are the chance for patients to acquire greater independence and safety in the home treatment, to allow better access to care for residents in remote areas, faster resolution of problems, reduction in hospitalizations and mortality rates, as well as time and cost saving for both the patient and the staff. […] The use of medical devices (sphygmomanometer, glucometer, balance, etc.), connected by wireless to the clinician’s portal, might also allow a wider diffusion of incremental dialysis, an integrated therapy that combines conservative management of ESKD patients with a soft dialysis based on the residual kidney function and symptomatology, with potential prognosis and economic benefits. | 2020-07-14 |
| 32658884 | Sixty-five patients adhere the televideoconsultation completely and were cured, also with home oxygen therapy and other treatments additional to the standard anti-inflammatory and antibiotic drugs. | 2020-07-14 |
| 32659214 | Demographic, clinical, laboratory, treatment, and outcome data were extracted from electronic medical records and compared between patients with moderate, severe, and critical disease (defined according to the diagnosis and treatment protocol for novel coronavirus pneumonia, trial version 7, published by the National Health Commission of China). | 2020-07-14 |
| 32659271 | In this short communication, we will evaluate the use of corticosteroids as an adjunctive pharmacological therapy in the management of COVID-19 and describe its pros and cons in light of the latest available evidence. | 2020-07-14 |
| 32659292 | To date, no vaccines or specific antiviral drugs have been approved for the treatment of this disease in clinic. […] These results highlight RBD-specific equine immunoglobulin F(ab’)2 fragment as a candidate for the treatment of SARS-CoV-2. | 2020-07-14 |
| 32659293 | In the context of the COVID-19 pandemic, several drugs have been repurposed as potential candidates for the treatment of COVID-19 infection. | 2020-07-14 |
| 32659462 | Early detection of suspected critical patients infected with coronavirus disease 2019 (COVID-19) is very important for the treatment of patients. […] A cohort study was designed from government designated COVID-19 treatment center. | 2020-07-14 |
| 32659475 | Of the patients that attended the hospital to receive cytotoxic chemotherapy alone or in combination with other therapy, 59 of 2001 (2.9%) were admitted to the hospital for COVID-19-related issues and 20 of 2001 (1%) died. […] Administration of systemic anticancer therapy appears to be associated with a modest risk of severe COVID-19 infection. […] Based on this snapshot taken as the first wave of COVID-19 hit our practice, we conclude that continuation of active cancer treatment, even in the palliative setting, is appropriate. | 2020-07-14 |
| 32659694 | We discussed issue of diabetes management in glycemic control and monitoring, dietary intake, physical activity, medication, education and prevention of COVID-19 infection that applicable for diabetes patients. | 2020-07-14 |
| 32659729 | COVID-19 pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and spreading worldwide has become a serious challenge for the entire health care system as regards infection prevention, rapid diagnosis, and treatment. | 2020-07-14 |
| 32659757 | There is no information on acute kidney injury (AKI) and continuous renal replacement therapy (CRRT) among invasively ventilated coronavirus disease 2019 (COVID-19) patients in Western healthcare systems. | 2020-07-14 |
| 32659783 | Second, because ADE of disease cannot be reliably predicted after either vaccination or treatment with antibodies-regardless of what virus is the causative agent-it will be essential to depend on careful analysis of safety in humans as immune interventions for COVID-19 move forward. | 2020-07-14 |
| 32660185 | Liver injury is a common complication of patients receiving COVID-19 treatment and its possible high incidence may affect the outcome of the disease. […] The pathogenesis of COVID-19 combined with liver injury in existing studies is still unclear, and relevant guidelines and expert consensuses are insufficient for clinical diagnosis and treatment. | 2020-07-15 |
| 32660307 | Because RdRP is a viral enzyme with no host cell homologs, selective SARS-CoV-2 RdRP inhibitors can be developed that have improved potency and fewer off-target effects against human host proteins and thus are safer and more effective therapeutics for treating COVID-19. | 2020-07-15 |
| 32660314 | Tempered CHX 0.2% presented the highest probabilities of being ranked the most effective treatment (31.2%). | 2020-07-15 |
| 32660334 | Existing data supports the use of OT for the treatment of existing and newly emerging cases of PVOD. | 2020-07-15 |
| 32660339 | Intranasal drug delivery has potential relevance for future clinical trials in the settings of disease spread prevention and treatment of SARS-CoV-2 and other viral diseases. | 2020-07-15 |
| 32660401 | The insights learned from previous respiratory viral infection control have given guidance into COVID- 19 therapy. | 2020-07-15 |
| 32660402 | Antiviral effects of NPC1-inhibiting drugs for COVID-19 treatment should be explored. | 2020-07-15 |
| 32660520 | The neurological manifestations of COVID-19 are not uncommon, but our study found most resolve with treatment of the underlying infection. | 2020-07-15 |
| 32660611 | Secondary Objectives • Number of days free of mechanical ventilation at Day 29 • Duration of intensive care unit stay at Day 29 • Change from baseline in Sequential Organ Failure Assessment (SOFA) score at Day 29 • Change from baseline in peripheral capillary oxygen saturation/ fraction of inspired oxygen (SpO2 /FiO2) at Day 29 • Duration of hospitalization at Day 29 • Survival (based on all-cause mortality) at Day 60 and Day 90 Safety • Incidence of treatment-emergent adverse events and treatment-emergent serious adverse events. […] Male or female patients at least 18 years of age, weighing ≥ 40 kg, admitted to a designated hospital facility for treatment will be screened for eligibility in this study. […] Key Inclusion criteria • Confirmed diagnosis of SARS-CoV-2 infection (eg, via polymerase chain reaction [PCR] and/or antibody test) presenting as severe COVID-19 requiring hospitalization • Severe pneumonia, acute lung injury, or ARDS confirmed by computed tomography (CT) or X-ray at Screening or within the 3 days prior to Screening, as part of the patient’s routine clinical care • Respiratory distress requiring mechanical ventilation, which can be either invasive (requiring endotracheal intubation) or non-invasive (with continuous positive airway pressure [CPAP] or bilevel positive airway pressure [BiPAP]) Key Exclusion criteria • Patient is not expected to survive for more than 24 hours • Patient is on invasive mechanical ventilation with intubation for more than 48 hours prior to Screening • Severe pre-existing cardiac disease (ie, NYHA Class 3 or Class 4, acute coronary syndrome, or persistent ventricular tachyarrhythmias) • Patient has an unresolved Neisseria meningitidis infection Excluded medications and therapies • Current treatment with a complement inhibitor • Intravenous immunoglobulin (IVIg) within 4 weeks prior to randomization on Day 1 Excluded prior/concurrent clinical study experience • Treatment with investigational therapy in a clinical study within 30 days before randomization, or within 5 half-lives of that investigational therapy, whichever is greater • Exceptions a. […] Investigational therapies will be allowed if received as part of best supportive care through an expanded access protocol or emergency approval for the treatment of COVID-19. b. […] The block size will be kept concealed so that investigators cannot select patients for a particular treatment assignment. | 2020-07-15 |
| 32660660 | We compared the 2007 and 2015 guidelines, with particular emphasis on the ethical issues and clinical protocols. […] Patients with the highest likelihood of short-term survival with ventilator therapy have priority access. […] Other forms of medical intervention/palliative care and review of triage decisions are discussed. | 2020-07-15 |
| 32660663 | The main measures include telephone triage, temperature taking on arrival at the office, the organization of the waiting room, washing hands before entering the office, knowing the auxiliary radiographic exams of choice and what type of treatment can be performed, albeit with restrictions. | 2020-07-15 |
| 32660890 | Many observational and prospective studies are ongoing or initiating to further examine the role of sex hormones in SARS-CoV-2 infection and if modulation of them is a realistic treatment option. | 2020-07-15 |
| 32660907 | Following verbal consent, participants were asked 8 open-ended questions, 5 on awareness about COVID-19 and 3 catering to problems being faced concerning diet, physical activity and treatment amid lockdown. […] Most participants could continue with their routine diet and prescribed treatment regime, however, 90% reported a reduction in physical activity and 72% experienced worsening of glycemic control amid lockdown. | 2020-07-15 |
| 32661006 | To the best of our knowledge, there is no published study on the use of interferon β-1a (IFN β-1a) in the treatment of severe COVID-19. | 2020-07-15 |
| 32661037 | As the pandemic decelerates, practices are now preparing to address the direct and indirect consequences-complications from COVID-19 infections, missed treatment for acute problems, inadequate prevention, uncontrolled chronic disease, mental illness, and greater social needs. | 2020-07-15 |
| 32661105 | The model was used to map critical drug requirements to available stock in Trusts and wholesalers/suppliers, enabling the identification of treatment capacity for these medicines regionally, both currently and for projected surges. | 2020-07-15 |
| 32661197 | It has placed intense pressure on the collective scientific community to develop therapeutics and vaccines, whose engineering relies on a detailed understanding of coronavirus biology. | 2020-07-15 |
| 32661375 | Currently, there is no worldwide-approved treatment for COVID-19. […] Nevertheless, it is important to generate knowledge on SARS-CoV-2 mechanisms of infection and its impact on host immunity, to guide the design of COVID-19 specific therapeutics and vaccines suitable for mass immunization. | 2020-07-15 |
| 32661487 | Despite receiving treatment dose anticoagulation and undergoing arterial embolectomy, revascularization was unsuccessful. | 2020-07-15 |
| 32661494 | Since the outbreak of the 2019 novel coronavirus disease (COVID-19), the medical research community is vigorously seeking a treatment to control the infection and save the lives of severely infected patients. […] In this short letter, we report our calculations on the inhibitors for the SARS-CoV-2 3CL protease and the spike protein for the potential treatment of COVID-19. | 2020-07-15 |
| 32661497 | Indeed, for many other viral infections, early treatment soon after development of symptoms is associated with decreased mortality, lower hospitalization rates, and lower likelihood of transmission to others. | 2020-07-15 |
| 32661499 | The severity of COVID-19 was negatively correlated with serum iron levels before and after treatment and was positively correlated with C-reactive protein, serum amyloid A, D-dimer, lactate dehydrogenase, urea nitrogen, and myoglobin levels. […] Seven (53.8%) patients with a lower serum iron level after treatment in the critical group had died. […] There was a significant difference in posttreatment serum iron levels between COVID-19 survivors and nonsurvivors. | 2020-07-15 |
| 32661507 | The general condition of the elderly should be considered during diagnosis and treatment. […] In addition to routine care and measures-such as oxygen therapy, antiviral therapy, and respiratory support-treatment of underlying disease, nutritional support, sputum expectoration complication prevention, and psychological support should also be considered for elderly patients. […] Based on a literature review and expert panel discussion, we drafted the “Recommendations for the Prevention and Treatment of the Novel Coronavirus Pneumonia in the elderly in China,” aiming to provide help with the prevention and treatment of NCP and the reduction of harm to the elderly population. | 2020-07-15 |
| 32661758 | System processes timings, treatment and clinical outcome variables were collected. […] Across the study period, number of stroke activations showed significant decline (p = 0.004, 95% CI 6.513 to - 2.287), as the number of COVID-19 cases increased exponentially, whilst proportion of activations receiving acute recanalization therapy remained stable (p = 0.519, 95% CI - 1.605 to 2.702). […] Amongst AIS patients that received acute recanalization therapy, early neurological outcomes in terms of change in median NIHSS at 24 h (-4 versus -4, p = 0.685) were largely similar between the pre- and during DORSCON orange periods. […] The number of stroke activations decreased while the proportion receiving acute recanalization therapy remained stable in the current COVID-19 pandemic in Singapore. | 2020-07-15 |
| 32661780 | The Italian College of Breast Radiologists by the Italian Society of Medical Radiology (SIRM) provides recommendations for breast care provision and procedural prioritization during COVID-19 pandemic, being aware that medical decisions must be currently taken balancing patient’s individual and community safety: (1) patients having a scheduled or to-be-scheduled appointment for in-depth diagnostic breast imaging or needle biopsy should confirm the appointment or obtain a new one; (2) patients who have suspicious symptoms of breast cancer (in particular: new onset palpable nodule; skin or nipple retraction; orange peel skin; unilateral secretion from the nipple) should request non-deferrable tests at radiology services; (3) asymptomatic women performing annual mammographic follow-up after breast cancer treatment should preferably schedule the appointment within 1 year and 3 months from the previous check, compatibly with the local organizational conditions; (4) asymptomatic women who have not responded to the invitation for screening mammography after the onset of the pandemic or have been informed of the suspension of the screening activity should schedule the check preferably within 3 months from the date of the not performed check, compatibly with local organizational conditions. | 2020-07-15 |
| 32661796 | Despite several studies, there is yet a dearth of data regarding the mechanisms of cardiac injury, clinical presentation, risk factors, and treatment of COVID-19-associated cardiovascular disease. […] This systematic review and meta-analysis is aimed at defining the clinical, electrocardiographic, and pathologic spectrum of cardiovascular disease (CVD), frequency of elevated cardiac and inflammatory biomarkers, and their frequency and relationship with severity of the disease and mortality in COVID-19 patients and to develop a triage risk stratification tool (TRST) that can serve as a guide for the timely recognition of the high-risk patients and mechanism-targeted therapy. […] There is a wide spectrum of cardiac involvement in COVID-19 patients, and hence a Triage Risk Stratification Tool can serve as a guide for the timely recognition of the high-risk patients and mechanism-targeted therapy. | 2020-07-15 |
| 32661859 | Thus, treatment can be personalized and adjusted to help protect and combat COVID-19 infections, especially in individuals with non-communicable diseases. […] Based on current published scientific and medical evidence, the suggestions made in this article for combination of vitamin therapy as epigenetic modifiers to control the unregulated inflammatory and cytokine marker expressions, further needs to be clinically proven. | 2020-07-15 |
| 32661928 | During pandemic, 375 (93%) were on colchicine treatment and 48 (11.8%) were receiving biologic treatment. […] Severe acute respiratory syndrome coronavirus-2 (SARS CoV-2) was identified through rhinopharyngeal swabs in seven patients, six of whom were only on colchicine treatment. […] In conclusion, pediatric patients with AIDs, those receiving biologic treatment and/or colchicine, may not be at increased risk for neither being infected nor the severe disease course. | 2020-07-15 |
| 32661930 | Much of the disaster planning in hospitals around the country addresses overcrowded emergency departments and decompressing these locations; however, in the case of COVID-19, intensive care units, emergency departments, and medical wards ran the risk of being overwhelmed by a large influx of patients needing high-level medical care. | 2020-07-15 |
| 32661947 | Despite being a trivial matter for patients in intensive care units (ICUs), erectile dysfunction (ED) is a likely consequence of COVID-19 for survivors, and considering the high transmissibility of the infection and the higher contagion rates among elderly men, a worrying phenomenon for a large part of affected patients. […] Treatment with phosphodiesterase-5 (PDE5) inhibitors might be beneficial for both COVID-19 and ED. | 2020-07-15 |
| 32662057 | Overall, intravenous medication was sparsely used during the procedure, with 48 of the 90 (53%) patients receiving no unplanned intravenous medication. […] This strategy may (temporarily) eliminate the need for an anaesthesiologist to be present in the cath lab and enables ongoing TAVI treatment amidst the global COVID-19 crisis. | 2020-07-15 |
| 32662060 | In the setting of an immunocompromised status due to recent chemotherapy cycles for lung adenocarcinoma and prolonged corticosteroid therapy (due to frequent exacerbations of chronic obstructive pulmonary disease in recent months), we actively searched for the pathological agent and found it to be Pneumocystis jirovecii. […] The patient started specific antibiotic treatment but finally had a negative outcome due to the progression of the lung adenocarcinoma. | 2020-07-15 |
| 32662099 | This study was aimed to discuss functional pathways related to NSPs in CoVs with updated knowledge regarding SARS CoV-2, mechanisms of action of certain approved and investigational drugs for correct orientation regarding the treatment strategies, including nucleotide analog mechanism, receptor analog mechanism, and peptide-peptide interactions, along with the impact of COVID-19 on a global scale. | 2020-07-15 |
| 32662571 | The coronavirus disease 2019 (COVID-19) pandemic has revealed major shortcomings in our ability to mitigate transmission of infectious viral disease and provide treatment to patients, resulting in a public health crisis. […] Strategies and opportunities for novel biomaterials intervention spanning diagnostics, treatment strategies, vaccines, and virus-deactivating surface coatings are discussed. | 2020-07-15 |
| 32662690 | So far, there is scarce evidence for the current treatment options available for COVID-19. […] Vitamin C has previously been used for treatment of severe sepsis and septic shock. […] We sequentially identified a series of patients who were requiring at least 30% of FiO2 or more who received IV vitamin C as part of the COVID-19 treatment and analyzed their demographic and clinical characteristics. […] We compared inflammatory markers pre and post treatment including D-dimer and ferritin. | 2020-07-15 |
| 32662742 | Our findings show no apparent difference in disease-modifying treatment (DMT) use and COVID-19 disease course in Dutch MS patients. | 2020-07-15 |
| 32662749 | Retrospective chart reviews were conducted to determine the patients’ demographic, disease, and treatment information. | 2020-07-15 |
| 32662814 | Although COVID-19 can be rapidly diagnosed, efficient clinical treatment of COVID-19 remains unavailable, resulting in high fatality. […] The aim of this study was to determine pharmacological targets and molecular mechanisms of VC + GA treatment for COVID-19, using bioinformational network pharmacology. […] Our findings suggested that combinatorial VC and GA treatment for COVID-19 was associated with elevation of immunity and suppression of inflammatory stress, including activation of the T cell receptor signaling pathway, regulation of Fc gamma R-mediated phagocytosis, ErbB signaling pathway and vascular endothelial growth factor signaling pathway. […] For the first time, our study uncovered the pharmacological mechanism underlying combined VC and GA treatment for COVID-19. | 2020-07-15 |
| 32662899 | Peripheral nervous system involvement after infection with COVID-19 is possible and may include several signs that may be successfully treated with immunoglobulin therapy. | 2020-07-15 |
| 32662949 | The findings advocate for an initiation of therapy of viral myocarditis as early as possible, even before the onset of inflammation-induced myocardial dysfunction. […] This may also have implications for coronavirus disease-19 therapy. | 2020-07-15 |
| 32662982 | Furthermore, some calcium channel blockers (CCBs), such as nimodipine, memantine, etc., have been reported to be effective in the treatment of dementia in Alzheimer’s disease (AD) as well as have shown inhibition in various virus infections. | 2020-07-15 |
| 32663256 | These differences may affect strategies for seroprevalence studies, therapeutics and vaccine development. | 2020-07-15 |
| 32663415 | This article aims to acquaint clinicians treating pediatric patients with COVID-19 hazards and delineate the steps required for minimizing cross-infection in case of providing emergency treatment to children in dental offices. | 2020-07-15 |
| 32663490 | The patient was prescribed anti-viral medication. | 2020-07-15 |
| 32663575 | The outbreak of Coronavirus disease 2019 (COVID-19) is the current world health concern, presenting a public health dilemma with ascending morbidity and mortality rates exceeding any previous viral spread, without a standard effective treatment yet. […] Taking into account that the vast majority of the COVID-19 cases are aggravated by the respiratory and multiorgan failure triggered by the sustained release of cytokines, implementing therapeutics that alleviate or diminish the upregulated inflammatory response would provide a therapeutic advantage to COVID-19 patients. […] This work focused on highlighting and contrasting the current success and limitations towards the involvement of these agents in future treatment protocols. | 2020-07-15 |
| 32663615 | Hospice care focuses on improving the quality of end-of-life care and respecting patients’ preferences regarding end-of-life treatment. […] Home care for hospice patients is an essential component of palliative care during a pandemic. | 2020-07-15 |
| 32663690 | Amid this natural experiment, current study evaluates prevailing municipal solid waste (MSW) management practices, with the emphasis on MSW treatment and disposal facilities in select developed and developing countries. […] Discussion includes identifying parameters of disease transmission through solid waste handling, consequences of medical waste surge on current municipal waste treatment and disposal systems. […] The paper recommends alternatives approaches for MSW treatment and disposal and outlines the future scope of work to achieve sustainable waste management during and aftermath of the pandemics. | 2020-07-15 |
| 32663742 | Tamoxifen treatment causes down-regulation, mutation, or loss in estrogen receptors. | 2020-07-15 |
| 32663827 | The principles of initiation, prescription, and complications related to renal replacement therapy are the same for coronavirus disease (COVID) patients as for non-COVID patients. […] Continuous renal replacement therapy (CRRT) remains the most common modality of treatment. | 2020-07-15 |
| 32664113 | However, there is still no effective drug to treat the disease, and acupuncture and moxibustion is utilized as adjuvant therapy for the treatment of COVID-19 in China. | 2020-07-16 |
| 32664179 | Isolation antiviral treatment. […] After 19 days of isolation and antiviral treatment, his temperature returned to normal and the symptoms were relieved. | 2020-07-16 |
| 32664185 | Tuina (massage) therapy is 1 of the widely employed complementary and alternative medicine interventions in the world. […] We will search the following electronic databases for randomized controlled trials to evaluate the effectiveness and safety of massage therapy in treating exercise-induced fatigue: China National Knowledge Infrastructure, Wanfang and Pubmed Database, Cochrane Central Register of Controlled Trials, Cumulative Index of Nursing and Allied Health Literature, Excerpta Medica database and MEDLINE. […] This proposed study will evaluate the effectiveness and safety of massage therapy for diarrhea symptoms in COVID-19 patients. […] This proposed systematic review will evaluate the existing evidence on the effectiveness and safety of massage therapy for diarrhea symptoms in COVID-19 patients.Dissemination and ethics: The results of this review will be disseminated through peer-reviewed publication. | 2020-07-16 |
| 32664543 | Increasing interest has been highlighted on the possible preventative role and adjunct treatment of lactoferrin, glycoprotein of human secretions part of a non-specific defensive system, known to play a crucial role against microbial and viral infections and exerting anti-inflammatory effects on different mucosal surfaces and able to regulate iron metabolism. […] In this review, analysing lactoferrin properties, we propose designing a clinical trial to evaluate and verify its effect using a dual combination treatment with local, solubilized intranasal spray formulation and oral administration. | 2020-07-16 |
| 32664709 | Patients with severe pneumonia caused by SARS-CoV-2 show more severe hypercytokinemia with corresponding lymphocytopenia than patients with mild pneumonia; thus, early immunomodulator treatment, including corticosteroids, has been considered. […] Since the immunopathogenesis of pneumonia may be the same for all patients regardless of age or severity and the critical immune-mediated lung injury may begin in the early stage of the disease, early immunomodulator treatment, including corticosteroids and intravenous immunoglobulin, can help reduce morbidity and possibly mortality rates of older patients with underlying conditions. | 2020-07-16 |
| 32664761 | Antithrombotic therapy was used in most cases. […] The antithrombotic therapy could play a role in the positive course of COVID-19 also in pregnant women. | 2020-07-16 |
| 32664810 | Results & methodology: Here we present two successful cases of tocilizumab administration in two COVID-19 patients with prior administration of antiviral therapy (hydroxychloroquine, azithromycin, lopinavir and ritonavir) with adequate response and resolution of ARDS, septic shock and severe pneumonia within the first 72 h. […] Discussion & conclusion: This case supports the usage of tocilizumab as an effective therapy in COVID-19 associated cytokine storm syndrome. | 2020-07-16 |
| 32664932 | Therefore, patients with severe COVID-19 should be screened for hyperinflammation using standard laboratory tests to identify those for whom immunosuppressive therapy may improve outcomes. | 2020-07-16 |
| 32664944 | People with coronavirus disease (COVID-19) may frequently require treatment with psychotropic medications, but are at the same time at higher risk for safety issues because of the complex underlying medical condition and the potential interaction with medical treatments. […] A set of practical recommendations was drawn in order to inform frontline clinicians on the assessment of the anticipated risk of psychotropic-related unfavorable events, and the possible actions to take in order to effectively manage this risk, such as when it is appropriate to avoid, withdraw, switch, or adjust the dose of the medication. | 2020-07-16 |
| 32664944 | People with coronavirus disease (COVID-19) may frequently require treatment with psychotropic medications, but are at the same time at higher risk for safety issues because of the complex underlying medical condition and the potential interaction with medical treatments. […] A set of practical recommendations was drawn in order to inform frontline clinicians on the assessment of the anticipated risk of psychotropic-related unfavorable events, and the possible actions to take in order to effectively manage this risk, such as when it is appropriate to avoid, withdraw, switch, or adjust the dose of the medication. | 2020-07-16 |
| 32664944 | People with coronavirus disease (COVID-19) may frequently require treatment with psychotropic medications, but are at the same time at higher risk for safety issues because of the complex underlying medical condition and the potential interaction with medical treatments. […] A set of practical recommendations was drawn in order to inform frontline clinicians on the assessment of the anticipated risk of psychotropic-related unfavorable events, and the possible actions to take in order to effectively manage this risk, such as when it is appropriate to avoid, withdraw, switch, or adjust the dose of the medication. | 2020-07-16 |
| 32664944 | People with coronavirus disease (COVID-19) may frequently require treatment with psychotropic medications, but are at the same time at higher risk for safety issues because of the complex underlying medical condition and the potential interaction with medical treatments. […] A set of practical recommendations was drawn in order to inform frontline clinicians on the assessment of the anticipated risk of psychotropic-related unfavorable events, and the possible actions to take in order to effectively manage this risk, such as when it is appropriate to avoid, withdraw, switch, or adjust the dose of the medication. | 2020-07-16 |
| 32664944 | People with coronavirus disease (COVID-19) may frequently require treatment with psychotropic medications, but are at the same time at higher risk for safety issues because of the complex underlying medical condition and the potential interaction with medical treatments. […] A set of practical recommendations was drawn in order to inform frontline clinicians on the assessment of the anticipated risk of psychotropic-related unfavorable events, and the possible actions to take in order to effectively manage this risk, such as when it is appropriate to avoid, withdraw, switch, or adjust the dose of the medication. | 2020-07-16 |
| 32664944 | People with coronavirus disease (COVID-19) may frequently require treatment with psychotropic medications, but are at the same time at higher risk for safety issues because of the complex underlying medical condition and the potential interaction with medical treatments. […] A set of practical recommendations was drawn in order to inform frontline clinicians on the assessment of the anticipated risk of psychotropic-related unfavorable events, and the possible actions to take in order to effectively manage this risk, such as when it is appropriate to avoid, withdraw, switch, or adjust the dose of the medication. | 2020-07-16 |
| 32664944 | People with coronavirus disease (COVID-19) may frequently require treatment with psychotropic medications, but are at the same time at higher risk for safety issues because of the complex underlying medical condition and the potential interaction with medical treatments. […] A set of practical recommendations was drawn in order to inform frontline clinicians on the assessment of the anticipated risk of psychotropic-related unfavorable events, and the possible actions to take in order to effectively manage this risk, such as when it is appropriate to avoid, withdraw, switch, or adjust the dose of the medication. | 2020-07-16 |
| 32664944 | People with coronavirus disease (COVID-19) may frequently require treatment with psychotropic medications, but are at the same time at higher risk for safety issues because of the complex underlying medical condition and the potential interaction with medical treatments. […] A set of practical recommendations was drawn in order to inform frontline clinicians on the assessment of the anticipated risk of psychotropic-related unfavorable events, and the possible actions to take in order to effectively manage this risk, such as when it is appropriate to avoid, withdraw, switch, or adjust the dose of the medication. | 2020-07-16 |
| 32664944 | People with coronavirus disease (COVID-19) may frequently require treatment with psychotropic medications, but are at the same time at higher risk for safety issues because of the complex underlying medical condition and the potential interaction with medical treatments. […] A set of practical recommendations was drawn in order to inform frontline clinicians on the assessment of the anticipated risk of psychotropic-related unfavorable events, and the possible actions to take in order to effectively manage this risk, such as when it is appropriate to avoid, withdraw, switch, or adjust the dose of the medication. | 2020-07-16 |
| 32664944 | People with coronavirus disease (COVID-19) may frequently require treatment with psychotropic medications, but are at the same time at higher risk for safety issues because of the complex underlying medical condition and the potential interaction with medical treatments. […] A set of practical recommendations was drawn in order to inform frontline clinicians on the assessment of the anticipated risk of psychotropic-related unfavorable events, and the possible actions to take in order to effectively manage this risk, such as when it is appropriate to avoid, withdraw, switch, or adjust the dose of the medication. | 2020-07-16 |
| 32664944 | People with coronavirus disease (COVID-19) may frequently require treatment with psychotropic medications, but are at the same time at higher risk for safety issues because of the complex underlying medical condition and the potential interaction with medical treatments. […] A set of practical recommendations was drawn in order to inform frontline clinicians on the assessment of the anticipated risk of psychotropic-related unfavorable events, and the possible actions to take in order to effectively manage this risk, such as when it is appropriate to avoid, withdraw, switch, or adjust the dose of the medication. | 2020-07-16 |
| 32664944 | People with coronavirus disease (COVID-19) may frequently require treatment with psychotropic medications, but are at the same time at higher risk for safety issues because of the complex underlying medical condition and the potential interaction with medical treatments. […] A set of practical recommendations was drawn in order to inform frontline clinicians on the assessment of the anticipated risk of psychotropic-related unfavorable events, and the possible actions to take in order to effectively manage this risk, such as when it is appropriate to avoid, withdraw, switch, or adjust the dose of the medication. | 2020-07-16 |
| 32664944 | People with coronavirus disease (COVID-19) may frequently require treatment with psychotropic medications, but are at the same time at higher risk for safety issues because of the complex underlying medical condition and the potential interaction with medical treatments. […] A set of practical recommendations was drawn in order to inform frontline clinicians on the assessment of the anticipated risk of psychotropic-related unfavorable events, and the possible actions to take in order to effectively manage this risk, such as when it is appropriate to avoid, withdraw, switch, or adjust the dose of the medication. | 2020-07-16 |
| 32664944 | People with coronavirus disease (COVID-19) may frequently require treatment with psychotropic medications, but are at the same time at higher risk for safety issues because of the complex underlying medical condition and the potential interaction with medical treatments. […] A set of practical recommendations was drawn in order to inform frontline clinicians on the assessment of the anticipated risk of psychotropic-related unfavorable events, and the possible actions to take in order to effectively manage this risk, such as when it is appropriate to avoid, withdraw, switch, or adjust the dose of the medication. | 2020-07-16 |
| 32664944 | People with coronavirus disease (COVID-19) may frequently require treatment with psychotropic medications, but are at the same time at higher risk for safety issues because of the complex underlying medical condition and the potential interaction with medical treatments. […] A set of practical recommendations was drawn in order to inform frontline clinicians on the assessment of the anticipated risk of psychotropic-related unfavorable events, and the possible actions to take in order to effectively manage this risk, such as when it is appropriate to avoid, withdraw, switch, or adjust the dose of the medication. | 2020-07-16 |
| 32664944 | People with coronavirus disease (COVID-19) may frequently require treatment with psychotropic medications, but are at the same time at higher risk for safety issues because of the complex underlying medical condition and the potential interaction with medical treatments. […] A set of practical recommendations was drawn in order to inform frontline clinicians on the assessment of the anticipated risk of psychotropic-related unfavorable events, and the possible actions to take in order to effectively manage this risk, such as when it is appropriate to avoid, withdraw, switch, or adjust the dose of the medication. | 2020-07-16 |
| 32664944 | People with coronavirus disease (COVID-19) may frequently require treatment with psychotropic medications, but are at the same time at higher risk for safety issues because of the complex underlying medical condition and the potential interaction with medical treatments. […] A set of practical recommendations was drawn in order to inform frontline clinicians on the assessment of the anticipated risk of psychotropic-related unfavorable events, and the possible actions to take in order to effectively manage this risk, such as when it is appropriate to avoid, withdraw, switch, or adjust the dose of the medication. | 2020-07-16 |
| 32664944 | People with coronavirus disease (COVID-19) may frequently require treatment with psychotropic medications, but are at the same time at higher risk for safety issues because of the complex underlying medical condition and the potential interaction with medical treatments. […] A set of practical recommendations was drawn in order to inform frontline clinicians on the assessment of the anticipated risk of psychotropic-related unfavorable events, and the possible actions to take in order to effectively manage this risk, such as when it is appropriate to avoid, withdraw, switch, or adjust the dose of the medication. | 2020-07-16 |
| 32664944 | People with coronavirus disease (COVID-19) may frequently require treatment with psychotropic medications, but are at the same time at higher risk for safety issues because of the complex underlying medical condition and the potential interaction with medical treatments. […] A set of practical recommendations was drawn in order to inform frontline clinicians on the assessment of the anticipated risk of psychotropic-related unfavorable events, and the possible actions to take in order to effectively manage this risk, such as when it is appropriate to avoid, withdraw, switch, or adjust the dose of the medication. | 2020-07-16 |
| 32664944 | People with coronavirus disease (COVID-19) may frequently require treatment with psychotropic medications, but are at the same time at higher risk for safety issues because of the complex underlying medical condition and the potential interaction with medical treatments. […] A set of practical recommendations was drawn in order to inform frontline clinicians on the assessment of the anticipated risk of psychotropic-related unfavorable events, and the possible actions to take in order to effectively manage this risk, such as when it is appropriate to avoid, withdraw, switch, or adjust the dose of the medication. | 2020-07-16 |
| 32664944 | People with coronavirus disease (COVID-19) may frequently require treatment with psychotropic medications, but are at the same time at higher risk for safety issues because of the complex underlying medical condition and the potential interaction with medical treatments. […] A set of practical recommendations was drawn in order to inform frontline clinicians on the assessment of the anticipated risk of psychotropic-related unfavorable events, and the possible actions to take in order to effectively manage this risk, such as when it is appropriate to avoid, withdraw, switch, or adjust the dose of the medication. | 2020-07-16 |
| 32664944 | People with coronavirus disease (COVID-19) may frequently require treatment with psychotropic medications, but are at the same time at higher risk for safety issues because of the complex underlying medical condition and the potential interaction with medical treatments. […] A set of practical recommendations was drawn in order to inform frontline clinicians on the assessment of the anticipated risk of psychotropic-related unfavorable events, and the possible actions to take in order to effectively manage this risk, such as when it is appropriate to avoid, withdraw, switch, or adjust the dose of the medication. | 2020-07-16 |
| 32664944 | People with coronavirus disease (COVID-19) may frequently require treatment with psychotropic medications, but are at the same time at higher risk for safety issues because of the complex underlying medical condition and the potential interaction with medical treatments. […] A set of practical recommendations was drawn in order to inform frontline clinicians on the assessment of the anticipated risk of psychotropic-related unfavorable events, and the possible actions to take in order to effectively manage this risk, such as when it is appropriate to avoid, withdraw, switch, or adjust the dose of the medication. | 2020-07-16 |
| 32664944 | People with coronavirus disease (COVID-19) may frequently require treatment with psychotropic medications, but are at the same time at higher risk for safety issues because of the complex underlying medical condition and the potential interaction with medical treatments. […] A set of practical recommendations was drawn in order to inform frontline clinicians on the assessment of the anticipated risk of psychotropic-related unfavorable events, and the possible actions to take in order to effectively manage this risk, such as when it is appropriate to avoid, withdraw, switch, or adjust the dose of the medication. | 2020-07-16 |
| 32664944 | People with coronavirus disease (COVID-19) may frequently require treatment with psychotropic medications, but are at the same time at higher risk for safety issues because of the complex underlying medical condition and the potential interaction with medical treatments. […] A set of practical recommendations was drawn in order to inform frontline clinicians on the assessment of the anticipated risk of psychotropic-related unfavorable events, and the possible actions to take in order to effectively manage this risk, such as when it is appropriate to avoid, withdraw, switch, or adjust the dose of the medication. | 2020-07-16 |
| 32664944 | People with coronavirus disease (COVID-19) may frequently require treatment with psychotropic medications, but are at the same time at higher risk for safety issues because of the complex underlying medical condition and the potential interaction with medical treatments. […] A set of practical recommendations was drawn in order to inform frontline clinicians on the assessment of the anticipated risk of psychotropic-related unfavorable events, and the possible actions to take in order to effectively manage this risk, such as when it is appropriate to avoid, withdraw, switch, or adjust the dose of the medication. | 2020-07-16 |
| 32664944 | People with coronavirus disease (COVID-19) may frequently require treatment with psychotropic medications, but are at the same time at higher risk for safety issues because of the complex underlying medical condition and the potential interaction with medical treatments. […] A set of practical recommendations was drawn in order to inform frontline clinicians on the assessment of the anticipated risk of psychotropic-related unfavorable events, and the possible actions to take in order to effectively manage this risk, such as when it is appropriate to avoid, withdraw, switch, or adjust the dose of the medication. | 2020-07-16 |
| 32664944 | People with coronavirus disease (COVID-19) may frequently require treatment with psychotropic medications, but are at the same time at higher risk for safety issues because of the complex underlying medical condition and the potential interaction with medical treatments. […] A set of practical recommendations was drawn in order to inform frontline clinicians on the assessment of the anticipated risk of psychotropic-related unfavorable events, and the possible actions to take in order to effectively manage this risk, such as when it is appropriate to avoid, withdraw, switch, or adjust the dose of the medication. | 2020-07-16 |
| 32664944 | People with coronavirus disease (COVID-19) may frequently require treatment with psychotropic medications, but are at the same time at higher risk for safety issues because of the complex underlying medical condition and the potential interaction with medical treatments. […] A set of practical recommendations was drawn in order to inform frontline clinicians on the assessment of the anticipated risk of psychotropic-related unfavorable events, and the possible actions to take in order to effectively manage this risk, such as when it is appropriate to avoid, withdraw, switch, or adjust the dose of the medication. | 2020-07-16 |
| 32664944 | People with coronavirus disease (COVID-19) may frequently require treatment with psychotropic medications, but are at the same time at higher risk for safety issues because of the complex underlying medical condition and the potential interaction with medical treatments. […] A set of practical recommendations was drawn in order to inform frontline clinicians on the assessment of the anticipated risk of psychotropic-related unfavorable events, and the possible actions to take in order to effectively manage this risk, such as when it is appropriate to avoid, withdraw, switch, or adjust the dose of the medication. | 2020-07-16 |
| 32664944 | People with coronavirus disease (COVID-19) may frequently require treatment with psychotropic medications, but are at the same time at higher risk for safety issues because of the complex underlying medical condition and the potential interaction with medical treatments. […] A set of practical recommendations was drawn in order to inform frontline clinicians on the assessment of the anticipated risk of psychotropic-related unfavorable events, and the possible actions to take in order to effectively manage this risk, such as when it is appropriate to avoid, withdraw, switch, or adjust the dose of the medication. | 2020-07-16 |
| 32664944 | People with coronavirus disease (COVID-19) may frequently require treatment with psychotropic medications, but are at the same time at higher risk for safety issues because of the complex underlying medical condition and the potential interaction with medical treatments. […] A set of practical recommendations was drawn in order to inform frontline clinicians on the assessment of the anticipated risk of psychotropic-related unfavorable events, and the possible actions to take in order to effectively manage this risk, such as when it is appropriate to avoid, withdraw, switch, or adjust the dose of the medication. | 2020-07-16 |
| 32664944 | People with coronavirus disease (COVID-19) may frequently require treatment with psychotropic medications, but are at the same time at higher risk for safety issues because of the complex underlying medical condition and the potential interaction with medical treatments. […] A set of practical recommendations was drawn in order to inform frontline clinicians on the assessment of the anticipated risk of psychotropic-related unfavorable events, and the possible actions to take in order to effectively manage this risk, such as when it is appropriate to avoid, withdraw, switch, or adjust the dose of the medication. | 2020-07-16 |
| 32664944 | People with coronavirus disease (COVID-19) may frequently require treatment with psychotropic medications, but are at the same time at higher risk for safety issues because of the complex underlying medical condition and the potential interaction with medical treatments. […] A set of practical recommendations was drawn in order to inform frontline clinicians on the assessment of the anticipated risk of psychotropic-related unfavorable events, and the possible actions to take in order to effectively manage this risk, such as when it is appropriate to avoid, withdraw, switch, or adjust the dose of the medication. | 2020-07-16 |
| 32664944 | People with coronavirus disease (COVID-19) may frequently require treatment with psychotropic medications, but are at the same time at higher risk for safety issues because of the complex underlying medical condition and the potential interaction with medical treatments. […] A set of practical recommendations was drawn in order to inform frontline clinicians on the assessment of the anticipated risk of psychotropic-related unfavorable events, and the possible actions to take in order to effectively manage this risk, such as when it is appropriate to avoid, withdraw, switch, or adjust the dose of the medication. | 2020-07-16 |
| 32664944 | People with coronavirus disease (COVID-19) may frequently require treatment with psychotropic medications, but are at the same time at higher risk for safety issues because of the complex underlying medical condition and the potential interaction with medical treatments. […] A set of practical recommendations was drawn in order to inform frontline clinicians on the assessment of the anticipated risk of psychotropic-related unfavorable events, and the possible actions to take in order to effectively manage this risk, such as when it is appropriate to avoid, withdraw, switch, or adjust the dose of the medication. | 2020-07-16 |
| 32664944 | People with coronavirus disease (COVID-19) may frequently require treatment with psychotropic medications, but are at the same time at higher risk for safety issues because of the complex underlying medical condition and the potential interaction with medical treatments. […] A set of practical recommendations was drawn in order to inform frontline clinicians on the assessment of the anticipated risk of psychotropic-related unfavorable events, and the possible actions to take in order to effectively manage this risk, such as when it is appropriate to avoid, withdraw, switch, or adjust the dose of the medication. | 2020-07-16 |
| 32664944 | People with coronavirus disease (COVID-19) may frequently require treatment with psychotropic medications, but are at the same time at higher risk for safety issues because of the complex underlying medical condition and the potential interaction with medical treatments. […] A set of practical recommendations was drawn in order to inform frontline clinicians on the assessment of the anticipated risk of psychotropic-related unfavorable events, and the possible actions to take in order to effectively manage this risk, such as when it is appropriate to avoid, withdraw, switch, or adjust the dose of the medication. | 2020-07-16 |
| 32664944 | People with coronavirus disease (COVID-19) may frequently require treatment with psychotropic medications, but are at the same time at higher risk for safety issues because of the complex underlying medical condition and the potential interaction with medical treatments. […] A set of practical recommendations was drawn in order to inform frontline clinicians on the assessment of the anticipated risk of psychotropic-related unfavorable events, and the possible actions to take in order to effectively manage this risk, such as when it is appropriate to avoid, withdraw, switch, or adjust the dose of the medication. | 2020-07-16 |
| 32664944 | People with coronavirus disease (COVID-19) may frequently require treatment with psychotropic medications, but are at the same time at higher risk for safety issues because of the complex underlying medical condition and the potential interaction with medical treatments. […] A set of practical recommendations was drawn in order to inform frontline clinicians on the assessment of the anticipated risk of psychotropic-related unfavorable events, and the possible actions to take in order to effectively manage this risk, such as when it is appropriate to avoid, withdraw, switch, or adjust the dose of the medication. | 2020-07-16 |
| 32664944 | People with coronavirus disease (COVID-19) may frequently require treatment with psychotropic medications, but are at the same time at higher risk for safety issues because of the complex underlying medical condition and the potential interaction with medical treatments. […] A set of practical recommendations was drawn in order to inform frontline clinicians on the assessment of the anticipated risk of psychotropic-related unfavorable events, and the possible actions to take in order to effectively manage this risk, such as when it is appropriate to avoid, withdraw, switch, or adjust the dose of the medication. | 2020-07-16 |
| 32664944 | People with coronavirus disease (COVID-19) may frequently require treatment with psychotropic medications, but are at the same time at higher risk for safety issues because of the complex underlying medical condition and the potential interaction with medical treatments. […] A set of practical recommendations was drawn in order to inform frontline clinicians on the assessment of the anticipated risk of psychotropic-related unfavorable events, and the possible actions to take in order to effectively manage this risk, such as when it is appropriate to avoid, withdraw, switch, or adjust the dose of the medication. | 2020-07-16 |
| 32664944 | People with coronavirus disease (COVID-19) may frequently require treatment with psychotropic medications, but are at the same time at higher risk for safety issues because of the complex underlying medical condition and the potential interaction with medical treatments. […] A set of practical recommendations was drawn in order to inform frontline clinicians on the assessment of the anticipated risk of psychotropic-related unfavorable events, and the possible actions to take in order to effectively manage this risk, such as when it is appropriate to avoid, withdraw, switch, or adjust the dose of the medication. | 2020-07-16 |
| 32664944 | People with coronavirus disease (COVID-19) may frequently require treatment with psychotropic medications, but are at the same time at higher risk for safety issues because of the complex underlying medical condition and the potential interaction with medical treatments. […] A set of practical recommendations was drawn in order to inform frontline clinicians on the assessment of the anticipated risk of psychotropic-related unfavorable events, and the possible actions to take in order to effectively manage this risk, such as when it is appropriate to avoid, withdraw, switch, or adjust the dose of the medication. | 2020-07-16 |
| 32664944 | People with coronavirus disease (COVID-19) may frequently require treatment with psychotropic medications, but are at the same time at higher risk for safety issues because of the complex underlying medical condition and the potential interaction with medical treatments. […] A set of practical recommendations was drawn in order to inform frontline clinicians on the assessment of the anticipated risk of psychotropic-related unfavorable events, and the possible actions to take in order to effectively manage this risk, such as when it is appropriate to avoid, withdraw, switch, or adjust the dose of the medication. | 2020-07-16 |
| 32664944 | People with coronavirus disease (COVID-19) may frequently require treatment with psychotropic medications, but are at the same time at higher risk for safety issues because of the complex underlying medical condition and the potential interaction with medical treatments. […] A set of practical recommendations was drawn in order to inform frontline clinicians on the assessment of the anticipated risk of psychotropic-related unfavorable events, and the possible actions to take in order to effectively manage this risk, such as when it is appropriate to avoid, withdraw, switch, or adjust the dose of the medication. | 2020-07-16 |
| 32664944 | People with coronavirus disease (COVID-19) may frequently require treatment with psychotropic medications, but are at the same time at higher risk for safety issues because of the complex underlying medical condition and the potential interaction with medical treatments. […] A set of practical recommendations was drawn in order to inform frontline clinicians on the assessment of the anticipated risk of psychotropic-related unfavorable events, and the possible actions to take in order to effectively manage this risk, such as when it is appropriate to avoid, withdraw, switch, or adjust the dose of the medication. | 2020-07-16 |
| 32664944 | People with coronavirus disease (COVID-19) may frequently require treatment with psychotropic medications, but are at the same time at higher risk for safety issues because of the complex underlying medical condition and the potential interaction with medical treatments. […] A set of practical recommendations was drawn in order to inform frontline clinicians on the assessment of the anticipated risk of psychotropic-related unfavorable events, and the possible actions to take in order to effectively manage this risk, such as when it is appropriate to avoid, withdraw, switch, or adjust the dose of the medication. | 2020-07-16 |
| 32664944 | People with coronavirus disease (COVID-19) may frequently require treatment with psychotropic medications, but are at the same time at higher risk for safety issues because of the complex underlying medical condition and the potential interaction with medical treatments. […] A set of practical recommendations was drawn in order to inform frontline clinicians on the assessment of the anticipated risk of psychotropic-related unfavorable events, and the possible actions to take in order to effectively manage this risk, such as when it is appropriate to avoid, withdraw, switch, or adjust the dose of the medication. | 2020-07-16 |
| 32664944 | People with coronavirus disease (COVID-19) may frequently require treatment with psychotropic medications, but are at the same time at higher risk for safety issues because of the complex underlying medical condition and the potential interaction with medical treatments. […] A set of practical recommendations was drawn in order to inform frontline clinicians on the assessment of the anticipated risk of psychotropic-related unfavorable events, and the possible actions to take in order to effectively manage this risk, such as when it is appropriate to avoid, withdraw, switch, or adjust the dose of the medication. | 2020-07-16 |
| 32664944 | People with coronavirus disease (COVID-19) may frequently require treatment with psychotropic medications, but are at the same time at higher risk for safety issues because of the complex underlying medical condition and the potential interaction with medical treatments. […] A set of practical recommendations was drawn in order to inform frontline clinicians on the assessment of the anticipated risk of psychotropic-related unfavorable events, and the possible actions to take in order to effectively manage this risk, such as when it is appropriate to avoid, withdraw, switch, or adjust the dose of the medication. | 2020-07-16 |
| 32664944 | People with coronavirus disease (COVID-19) may frequently require treatment with psychotropic medications, but are at the same time at higher risk for safety issues because of the complex underlying medical condition and the potential interaction with medical treatments. […] A set of practical recommendations was drawn in order to inform frontline clinicians on the assessment of the anticipated risk of psychotropic-related unfavorable events, and the possible actions to take in order to effectively manage this risk, such as when it is appropriate to avoid, withdraw, switch, or adjust the dose of the medication. | 2020-07-16 |
| 32664944 | People with coronavirus disease (COVID-19) may frequently require treatment with psychotropic medications, but are at the same time at higher risk for safety issues because of the complex underlying medical condition and the potential interaction with medical treatments. […] A set of practical recommendations was drawn in order to inform frontline clinicians on the assessment of the anticipated risk of psychotropic-related unfavorable events, and the possible actions to take in order to effectively manage this risk, such as when it is appropriate to avoid, withdraw, switch, or adjust the dose of the medication. | 2020-07-16 |
| 32664944 | People with coronavirus disease (COVID-19) may frequently require treatment with psychotropic medications, but are at the same time at higher risk for safety issues because of the complex underlying medical condition and the potential interaction with medical treatments. […] A set of practical recommendations was drawn in order to inform frontline clinicians on the assessment of the anticipated risk of psychotropic-related unfavorable events, and the possible actions to take in order to effectively manage this risk, such as when it is appropriate to avoid, withdraw, switch, or adjust the dose of the medication. | 2020-07-16 |
| 32664944 | People with coronavirus disease (COVID-19) may frequently require treatment with psychotropic medications, but are at the same time at higher risk for safety issues because of the complex underlying medical condition and the potential interaction with medical treatments. […] A set of practical recommendations was drawn in order to inform frontline clinicians on the assessment of the anticipated risk of psychotropic-related unfavorable events, and the possible actions to take in order to effectively manage this risk, such as when it is appropriate to avoid, withdraw, switch, or adjust the dose of the medication. | 2020-07-16 |
| 32664944 | People with coronavirus disease (COVID-19) may frequently require treatment with psychotropic medications, but are at the same time at higher risk for safety issues because of the complex underlying medical condition and the potential interaction with medical treatments. […] A set of practical recommendations was drawn in order to inform frontline clinicians on the assessment of the anticipated risk of psychotropic-related unfavorable events, and the possible actions to take in order to effectively manage this risk, such as when it is appropriate to avoid, withdraw, switch, or adjust the dose of the medication. | 2020-07-16 |
| 32664944 | People with coronavirus disease (COVID-19) may frequently require treatment with psychotropic medications, but are at the same time at higher risk for safety issues because of the complex underlying medical condition and the potential interaction with medical treatments. […] A set of practical recommendations was drawn in order to inform frontline clinicians on the assessment of the anticipated risk of psychotropic-related unfavorable events, and the possible actions to take in order to effectively manage this risk, such as when it is appropriate to avoid, withdraw, switch, or adjust the dose of the medication. | 2020-07-16 |
| 32664944 | People with coronavirus disease (COVID-19) may frequently require treatment with psychotropic medications, but are at the same time at higher risk for safety issues because of the complex underlying medical condition and the potential interaction with medical treatments. […] A set of practical recommendations was drawn in order to inform frontline clinicians on the assessment of the anticipated risk of psychotropic-related unfavorable events, and the possible actions to take in order to effectively manage this risk, such as when it is appropriate to avoid, withdraw, switch, or adjust the dose of the medication. | 2020-07-16 |
| 32664944 | People with coronavirus disease (COVID-19) may frequently require treatment with psychotropic medications, but are at the same time at higher risk for safety issues because of the complex underlying medical condition and the potential interaction with medical treatments. […] A set of practical recommendations was drawn in order to inform frontline clinicians on the assessment of the anticipated risk of psychotropic-related unfavorable events, and the possible actions to take in order to effectively manage this risk, such as when it is appropriate to avoid, withdraw, switch, or adjust the dose of the medication. | 2020-07-16 |
| 32664944 | People with coronavirus disease (COVID-19) may frequently require treatment with psychotropic medications, but are at the same time at higher risk for safety issues because of the complex underlying medical condition and the potential interaction with medical treatments. […] A set of practical recommendations was drawn in order to inform frontline clinicians on the assessment of the anticipated risk of psychotropic-related unfavorable events, and the possible actions to take in order to effectively manage this risk, such as when it is appropriate to avoid, withdraw, switch, or adjust the dose of the medication. | 2020-07-16 |
| 32664944 | People with coronavirus disease (COVID-19) may frequently require treatment with psychotropic medications, but are at the same time at higher risk for safety issues because of the complex underlying medical condition and the potential interaction with medical treatments. […] A set of practical recommendations was drawn in order to inform frontline clinicians on the assessment of the anticipated risk of psychotropic-related unfavorable events, and the possible actions to take in order to effectively manage this risk, such as when it is appropriate to avoid, withdraw, switch, or adjust the dose of the medication. | 2020-07-16 |
| 32664944 | People with coronavirus disease (COVID-19) may frequently require treatment with psychotropic medications, but are at the same time at higher risk for safety issues because of the complex underlying medical condition and the potential interaction with medical treatments. […] A set of practical recommendations was drawn in order to inform frontline clinicians on the assessment of the anticipated risk of psychotropic-related unfavorable events, and the possible actions to take in order to effectively manage this risk, such as when it is appropriate to avoid, withdraw, switch, or adjust the dose of the medication. | 2020-07-16 |
| 32664944 | People with coronavirus disease (COVID-19) may frequently require treatment with psychotropic medications, but are at the same time at higher risk for safety issues because of the complex underlying medical condition and the potential interaction with medical treatments. […] A set of practical recommendations was drawn in order to inform frontline clinicians on the assessment of the anticipated risk of psychotropic-related unfavorable events, and the possible actions to take in order to effectively manage this risk, such as when it is appropriate to avoid, withdraw, switch, or adjust the dose of the medication. | 2020-07-16 |
| 32664944 | People with coronavirus disease (COVID-19) may frequently require treatment with psychotropic medications, but are at the same time at higher risk for safety issues because of the complex underlying medical condition and the potential interaction with medical treatments. […] A set of practical recommendations was drawn in order to inform frontline clinicians on the assessment of the anticipated risk of psychotropic-related unfavorable events, and the possible actions to take in order to effectively manage this risk, such as when it is appropriate to avoid, withdraw, switch, or adjust the dose of the medication. | 2020-07-16 |
| 32664949 | However, there is no specific treatment for COVID-19 and much remains unknown about this disease. | 2020-07-16 |
| 32664991 | Chest CT can assess the severity of COVID-19 and has sufficient sensitivity to assess changes in response to glucocorticoid therapy. […] Treatment with a glucocorticoid increased the LY count, reduced the CT score and CRP level, and improved coagulation function. […] Glucocorticoid treatment appears to reduce systemic inflammation in these patients. | 2020-07-16 |
| 32665039 | Frontline HCWs aged 18 years of age or older, at high risk of SARS-CoV-2 exposure (including staff of emergency departments, intensive care units, intubation teams, COVID-wards, and staff deployed to Long Term Care facilities) of five academic hospitals in downtown Toronto, Canada. | 2020-07-16 |
| 32665040 | This is an open-label study, with researchers assessing the laboratory outcomes blinded to treatment allocation. | 2020-07-16 |
| 32665041 | HEP will be an active treatment program that incorporates mind-body interventions. […] HEP will consist of time-matched online self-paced modules with psychoeducation on healthy active living as well as interactive modules comprising of guided de-stressing exercises including music therapy, mindfulness and progressive muscle relaxation. | 2020-07-16 |
| 32665090 | The use of certain drugs for autoimmune inflammatory rheumatisms appears to be a potentially interesting options for the treatment. […] Notably, patients on chloroquine or hydroxychloroquine as a treatment for their autoimmune rheumatic disease are not protected from COVID-19. | 2020-07-16 |
| 32665227 | During the coronavirus disease 2019 outbreak, the treatment of families with children on long-term KRT is challenging. […] This study was conducted to identify the current difficulties, worries regarding the next 2 months, and mental distress experienced by families with children on long-term KRT during the coronavirus disease 2019 outbreak and to deliver possible management approaches to ensure uninterrupted treatment for children on long-term KRT. […] At the time of the submission of this paper, no treatment interruption had been reported. | 2020-07-16 |
| 32665259 | Patients applying the outpatient clinic and outpatient palliative care (OPC) clinic for the first time and patients admitted to inpatient wards in the first 30 days after the first case of COVID-19 in Turkey were evaluated. […] By comparison, the rate of hospitalisations for palliative care (p=0.028) or elective interventional procedures (p=0.001) was significantly reduced. […] There were significant drops in the numbers of newly diagnosed patients, patients having interventional procedures and palliative care services, and these problems should be the focus points for the risk mitigation efforts for prevention of care disruptions. | 2020-07-16 |
| 32665352 | We aim to investigate the effects of respiratory rehabilitation therapy on patients infected with the novel coronavirus by conducting a systematic review and meta-analysis. | 2020-07-16 |
| 32665394 | Our secondary outcomes include resuscitation preferences, palliative care consultations, death, hospice use and final cancer-directed therapy. | 2020-07-16 |
| 32665420 | Demographics, symptoms, comorbidities, treatment, and mortality of patients whose sera were used were also reviewed. | 2020-07-16 |
| 32665542 | Thus, CoVex is a resource to understand molecular mechanisms of pathogenicity and to prioritize candidate therapeutics. | 2020-07-16 |
| 32665633 | The objective of this study is to expound the CT features of COVID-19 patients whose throat swab samples were negative for two consecutive nucleic acid tests after treatment. […] We retrospectively reviewed 46 COVID-19 patients with two consecutive negative RT-PCR tests after treatment. | 2020-07-16 |
| 32665751 | This study aimed to compare the treatment pathway and 30-day outcomes of hip fracture patients admitted during the COVID-19 pandemic with the pre-pandemic period. […] No statistically significant differences in time to surgery, type of treatment, complications, and mortality rates were noted. […] Institutional adaptions to facilitate prompt treatment in hip fractures during the pandemic resulted in favourable outcomes. | 2020-07-16 |
| 32665783 | Based on the past contribution of traditional Chinese medicines (TCM) and immune-based therapies as a treatment option in crucial pathogen outbreaks, we aimed to summarize potential therapeutic strategies that could be helpful to stop further spread of SARS-CoV-2 by effecting its structural components or modulation of immune responses. | 2020-07-16 |
| 32665786 | Based on traumatology experience, we propose that immunoprotective protocols including lung protective ventilation, optimal thrombosis prophylaxis, secondary infection prevention and calculated antibiotic therapy are likely also beneficial in the treatment of SARS-CoV-2 infections. […] Finally, rising SARS-CoV-2 infection and mortality rates mandate exploration of out-of-the box treatment concepts, including experimental therapies designed for trauma care. | 2020-07-16 |
| 32665808 | By discussing the current inventory of viral inhibitors, we identify molecular scaffolds that may be improved by medicinal chemistry efforts for effective therapeutics to treat current and future coronavirus-caused diseases. | 2020-07-16 |
| 32665809 | With its synthetic simplicity and in vivo efficacy in the veterinary setting, we contend that GS-441524 is superior to remdesivir for Covid-19 treatment. | 2020-07-16 |
| 32665935 | The severity of haemorrhagic syndrome is not correlated with the severity of COVID-19 infection.Thrombocytopenia in mild COVID-19 infection seems to have an autoimmune mechanism.Intravenous immunoglobulins (1 g/kg) should be the first line of treatment. | 2020-07-16 |
| 32665938 | Single room accommodation should be preferred to double room accommodation in standard wards during the COVID-19 pandemic.Anticoagulation therapy and the presence of lupus anticoagulant may induce cutaneous complications during COVID-19 infection.The discontinuation of anticoagulation therapy did not help improve the management of cutaneous lesions. | 2020-07-16 |
| 32665940 | Patients with COVID-19 pneumonia who are receiving non-vitamin K antagonists or direct oral anticoagulants for chronic disease are usually switched to heparin treatment during hospitalization. […] However, information about the most appropriate antithrombotic therapy after the acute infection phase is lacking. […] Four weeks after discharge he experienced an episode of an acute pulmonary embolism while on rivaroxaban therapy with adequate drug plasma levels, and in the absence of strong predisposing risk factors. […] This case highlights the risk of thrombotic complications after COVID-19 infection, raises some concern about their underlying mechanisms, and supports the use of effective anti-thrombotic therapy. […] COVID-19 infection is associated with frequent thrombotic events.A pro-coagulative status could be triggered by the persistent inflammatory phase of the infection despite anticoagulation.Adequate antithrombotic therapy is necessary for the prevention of acute and later thrombotic complications and needs close monitoring. | 2020-07-16 |
| 32665942 | One of the main pathophysiological hypotheses for severe COVID-19 pneumonia is inappropriate immunological hyperactivation.Corticosteroid therapy may be useful in these patients. | 2020-07-16 |
| 32665962 | Recently, a critical debatable question has arisen whether using antihypertensive medications will have a favorable impact on people infected with SARS-CoV-2 or a deleterious one, mainly because angiotensin-converting enzyme inhibitor (ACEI) and angiotensin-receptor blocker (ARB) therapy can modulate the expression of ACE2 protein. | 2020-07-16 |
| 32665963 | Currently there is no effective proven drug for the treatment of COVID-19; therefore, development of effective therapeutic drugs to suppress SARS-CoV-2 infection is urgently needed. […] Then, we review the clinical symptoms, diagnosis, and treatment options of COVID-19 patients. […] We further discuss the potential molecular targets and drug development strategies for treatment of the emerging COVID-19. […] This review provides some insights for the treatment of COVID-19. | 2020-07-16 |
| 32665967 | Throughout the patient care pathway, there are opportunities for ML-supported decisions based on collected vitals, laboratory results, medication orders, and comorbidities. | 2020-07-16 |
| 32666088 | In response to the coronavirus pandemic, New York State mandated that all hospitals double the capacity of their adult intensive care units In this facility, resources were mobilized to increase from 104 to 283 beds. […] Curricular elements included respiratory failure and ventilator management, shock and hemodynamics, pharmacotherapy for critical illnesses, and renal replacement therapy. […] As of June 2020, 151 patients with coronavirus disease 2019 still required mechanical ventilation at our institution, and 7 of 10 temporary intensive care units remained operational. | 2020-07-16 |
| 32666137 | In addition, the myriad of antiviral drugs presently being tried in the treatment of COVID-19 can result in several rheumatic musculoskeletal adverse effects. […] In this review, we have addressed the possible spectrum and mechanisms of various autoimmune and rheumatic musculoskeletal manifestations that can be precipitated by COVID-19 infection, its therapy, and the preventive strategies to contain the infection. | 2020-07-16 |
| 32666376 | The use of technology and risk stratification to establish the priority of access to the treatments that we have been forced to undertake will be useful tools for a new phase of a more efficient and successful treatment of diabesity. | 2020-07-16 |
| 32666676 | We have reviewed the mechanistic evidence in four major areas that are relevant to the management of COVID-19. (a) Assessment of combination therapy for MERS highlights the need for systematic assessment of mechanistic evidence. (b) That hypertension is a risk factor for severe disease in the case of SARS-CoV-2 suggests that altering hypertension treatment might alleviate disease, but the mechanisms are complex, and it is essential to consider and evaluate multiple mechanistic hypotheses. (c) Confidence that public health interventions will be effective requires a detailed assessment of social and psychological components of the mechanisms of their action, in addition to mechanisms of disease. (d) In particular, if vaccination programmes are to be effective, they must be carefully tailored to the social context; again, mechanistic evidence is crucial. | 2020-07-16 |
| 32666816 | Key trial design elements useful in this circumstance include futility hypotheses, treatment pooling, reciprocal controls, ranking and selection, and platform administration. […] Assuming most of the many candidates for COVID-19 treatment are likely to be ineffective, these components can be combined to facilitate very efficient comparisons of treatments. […] Simulations indicate such designs can reliably discard underperforming treatments using sample size to treatment ratios under 30. | 2020-07-16 |
| 32666857 | Objectives: We conducted a phone survey among 123 OPWH with substance use disorders (SUD) in Kyiv in May 2020 to learn if these older adults may continue HIV and SUD therapy while coping with the Covid-19 pandemic. […] Results: Data from the survey demonstrated that while OPWH with SUD maintained HIV and SUD therapy throughout Covid-19 lockdown, social support is critical to avoiding treatment interruption for OPWH with SUD. […] Post-Covid-19 pharmacological approaches to SUD treatment without social support are like vehicles without gas. | 2020-07-16 |
| 32666875 | Therapeutic plasma exchange (TPE) merits consideration in the treatment of critically ill COVID-19 patients and is an avenue for clinical trials to pursue. […] Herein, we briefly discuss some of the various approaches currently being investigated for the treatment of SARS-CoV-2 with a focus on potential benefits of TPE for selected critically ill patients. | 2020-07-16 |
| 32666887 | Therefore, the goal of this report is to share our own experiences, combined with a review of the emerging literature, by highlighting principles for the adult cardiac surgery community regarding treatment of patients scheduled for surgery. | 2020-07-16 |
| 32666912 | The COVID-19 pandemic has altered clinical practice and education in manual therapy globally. […] Education in manual therapy has moved to online platforms with in-person instruction restricted. […] The global impact on the clinical practice of manual therapy and education has to date not been explored. a questionnaire survey methodology was used. […] A sample of convenience of global leaders in manual therapy practice and education received an electronic link to two surveys: one on clinical practice and one on education. […] Twenty-five surveys were received on clinical practice and 23 on education in manual therapy, representing the six major continents. […] Global themes in clinical practice demonstrated a sudden and dramatic shift away from patient contact, with limited modifications to manual therapy in patient care currently adopted. […] The international perspectives provided demonstrate a major change in manual therapy practice and education globally. | 2020-07-16 |
| 32667047 | However, we strongly believe that the existing evidence is enough to raise awareness among clinicians and help guide them through the diagnosis and optimal therapy of COVID-19 patients. | 2020-07-16 |
| 32667077 | Moreover, we need a keen eye on deciding which pathologies have to be treated with priority: Coronary artery Disease showed a higher mortality rate in patients affected by COVID19, but it is, however, reasonable to think that all the cardiac pathologies affecting the lung circulation-such as symptomatic severe mitral diseases or aortic stenosis-might deserve a priority access to treatment, to increase the survival rate in case of an acquired-Coronavirus infection later on. | 2020-07-16 |
| 32667150 | COronaVIrus Disease 2019 (COVID-19) pandemic is quickly spreading, putting under heavy stress health systems worldwide and especially Intensive Care Units (ICU). […] This study could provide an accurate description of COVID-19 subacute patients admitted to a Rehabilitation Unit along with a proposal of treatment to help physicians to tailor the best possible rehabilitative treatment. | 2020-07-16 |
| 32667391 | There are few data on the impact of COVID-19 in pregnancy, however, analyzing these data is important to guide the clinical practice, covering the early prevention, detection, patients’ isolation, epidemiological investigation, diagnosis and early treatment. | 2020-07-16 |
| 32667418 | MEDLINE® and Embase databases were extensively searched for major clinical manifestations of gastrointestinal involvement in children and adolescents with COVID-19 reported in medical literature, and for nutritional therapy-related data. […] Nutritional support plays an important role in treatment of pediatric patients, particularly those with severe or critical forms of the disease. […] Nutritional therapy is vital to prevent malnutrition and sarcopenia in severe cases. | 2020-07-16 |
| 32667435 | Admissions to intensive care units have suddenly increased, but many of these patients do not present with clinical manifestations related to the viral infection but rather exacerbation of preexisting diseases. | 2020-07-16 |
| 32667444 | Different therapies are currently used, considered, or proposed for the treatment of COVID-19; for many of those therapies, no appropriate assessment of effectiveness and safety was performed. […] This document aims to provide scientifically available evidence-based information in a transparent interpretation, to subsidize decisions related to the pharmacological therapy of COVID-19 in Brazil. […] We do not recommend the routine use of hydroxychloroquine, chloroquine, azithromycin, lopinavir/ritonavir, corticosteroids, or tocilizumab for the treatment of COVID-19. […] So far no pharmacological intervention was proven effective and safe to warrant its use in the routine treatment of COVID-19 patients; therefore such patients should ideally be treated in the context of clinical trials. | 2020-07-16 |
| 32667665 | Notably, the two antiviral drugs have also previously been identified using molecular docking methods, and ribavirin is a recommended drug in the diagnosis and treatment protocol for COVID pneumonia (trial version 5-7) published by the National Health Commission of the P.R. of China. […] Our study demonstrates the value of the cogena-based drug repositioning method for emerging infectious diseases, improves our understanding of SARS-CoV-2-induced disease, and provides potential drugs for the prevention and treatment of COVID-19 pneumonia. | 2020-07-16 |
| 32667668 | The US is currently an epicenter of the coronavirus disease 2019 (COVID-19) pandemic, yet few national data are available on patient characteristics, treatment, and outcomes of critical illness from COVID-19. […] To assess factors associated with death and to examine interhospital variation in treatment and outcomes for patients with COVID-19. […] This multicenter cohort study assessed 2215 adults with laboratory-confirmed COVID-19 who were admitted to intensive care units (ICUs) at 65 hospitals across the US from March 4 to April 4, 2020. […] Multilevel logistic regression was used to evaluate factors associated with death and to examine interhospital variation in treatment and outcomes. | 2020-07-16 |
| 32667669 | To evaluate the independent risk factors associated with mortality of patients with COVID-19 requiring treatment in ICUs in the Lombardy region of Italy. […] No medication was independently associated with mortality (angiotensin-converting enzyme inhibitors HR, 1.17; 95% CI, 0.97-1.42; angiotensin receptor blockers HR, 1.05; 95% CI, 0.85-1.29). | 2020-07-16 |
| 32667699 | Treatment options for severe acute respiratory syndrome-related coronavirus-2 (SARS-CoV-2) are limited with no clarity on efficacy and safety profiles. | 2020-07-16 |
| 32668007 | A total of 99 patients (median age 67 years [interquartile range 56–76], 37% females) were included and 35% developed severe COVID-19 progression (24% needed ICU treatment, 19% died). | 2020-07-16 |
| 32668015 | The 51% of patients were tested during their admission for SARS-CoV-2; 5% were diagnosed/developed symptoms of SARS-CoV-2 during and until 14 days post-discharge; four were male and one female, mean age 41.2 years (range, 17-75 years), all had primary malignant bone or soft-tissue tumours, four of five had received immunosuppressive therapy pre-operatively. | 2020-07-16 |
| 32668034 | Majority guidelines for various types of cancers favored a delay in treatment or a nonsurgical approach wherever feasible. | 2020-07-16 |
| 32668037 | Various nutrition societies have recently published their guidelines in context of the pandemic, and several points emphasize the impact of these GI manifestations on nutrition therapy. […] Among patients admitted to intensive care units, a significant barrier is GI intolerance, and it appears to be exacerbated by significant GI involvement specific to the SARS-CoV-2 infection. | 2020-07-16 |
| 32668041 | We describe veno-venous (VV) ECMO in a COVID-19-positive woman with hypoxic respiratory dysfunction failing mechanical ventilation support while prone and receiving inhaled pulmonary vasodilator therapy. […] With proper patient selection and careful attention to hemodynamic management, ECMO remains a reasonable treatment option for patients with COVID-19. | 2020-07-16 |
| 32668047 | While it is essential to prevent the virus from resurging and focus on developing a COVID-19 treatment as soon as possible, it is just as important to our society that we continue developing new drugs for other conditions. | 2020-07-16 |
| 32668058 | Thirty percent of Covid-19 patients admitted to intensive care units present with thrombotic complications despite thromboprophylaxis. […] Better understanding of the underlying mechanisms leading to thrombosis is crucial for developing more appropriate prophylaxis and treatment strategies. […] We observed two key findings: a high thrombin generation capacity that remained within normal values despite heparin therapy and a hypofibrinolysis mainly associated with increased PAI-1 levels. | 2020-07-16 |
| 32668134 | Nutritional interventions have attained considerable scientific evidence in disease prevention and treatment. | 2020-07-16 |
| 32668216 | These data demonstrate that RDV is potently active against SARS-CoV-2 in vitro and in vivo, supporting its further clinical testing for treatment of COVID-19. | 2020-07-16 |
| 32668312 | Iron oxide nanoparticles (IONPs) were previously approved by the US food and drug administration (FDA) for anemia treatment and studies have also demonstrated its antiviral activity in vitro. […] Therefore, we recommend FDA-approved-IONPs to proceed for COVID-19 treatment clinical trials. | 2020-07-16 |
| 32668317 | SARS-CoV-2 RNAemia peaked several days later, followed by a seroconversion despite the absence of circulating CD19-positive lymphocytes at admission due to rituximab-based treatment of antibody-mediated rejection 3 months earlier. | 2020-07-16 |
| 32668512 | Emergency use authorization for some laboratory diagnostic kits has been granted, enabling the timely diagnosis and treatment of COVID-19, and the isolation of infected patients. | 2020-07-16 |
| 32668763 | Clinical characteristics, laboratory findings, and treatment strategies were retrospectively reviewed for the analysis. […] Meta-analysis of treatment approaches indicated that three modalities of treatment were predominantly used in the majority of patients with a similar prevalence, including antiviral agents (79%), antibiotics (78%), and oxygen therapy (77%). […] Moreover, treatments such as antiviral agents, antibiotics, and oxygen therapy which are used in over three quarters of patients are also analyzed. | 2020-07-17 |
| 32668803 | SARS-CoV-2 infection/COVID-19 provides numerous therapeutic targets, each of them promising, but not leading to the success of therapy to date. […] Neither an antiviral nor an immunomodulatory therapy in patients with SARS-CoV-2 infection/COVID-19 or pre-exposure prophylaxis against SARS-CoV-2 has proved to be effective. […] In this review, we try to close the gap and point out the likely relationships among lysosomotropism, increasing lysosomal pH, SARS-CoV-2 infection, and disease process, and we deduce an approach for the treatment and prophylaxis of COVID-19, and cytokine release syndrome (CRS)/cytokine storm triggered by bacteria or viruses. […] As supported by recent clinical data, patients who have already taken lysosomotropic drugs for other pre-existing conditions likely benefit from this treatment in the COVID-19 pandemic. | 2020-07-17 |
| 32668969 | No specific treatment and vaccine with documented safety and efficacy for the disease have been established. […] Hence it is of utmost importance to identify more therapeutics such as Chinese medicine formulae to meet the urgent need. […] While large scale clinical studies on QFPDT are being conducted in China, one should use real world data for exploration of integrative treatment with inclusion of pharmacokinetic, pharmacodynamic and herb-drug interaction studies. | 2020-07-17 |
| 32668970 | Seven versions of the Diagnosis and Treatment Program for Coronavirus Disease-2019 successively issued by the Chinese government have designated traditional Chinese medicine (TCM) as a necessary medical strategy. […] Based on the changes in TCM diagnosis and treatment strategies in these seven versions of Diagnosis and Treatment Program for Coronavirus Disease-2019, this paper collected data reported by the Chinese government media; analyzed the understanding of the etiology, pathogenesis, syndrome differentiation, treatment methods, and prescriptions of COVID-19 by TCM and evaluated the clinical efficacy of TCM strategies. | 2020-07-17 |
| 32669027 | The thrombosis has been resolved with anticoagulant therapy with low molecular weight heparin of 100 IU/kg bid without giving pulmonary embolism. | 2020-07-17 |
| 32669265 | Given that sufficient safety and efficacy data are available for GC376 as an investigational veterinary drug, expedited development of GC376, or its optimized analogues, for treatment of SARS-CoV-2 infection in human is recommended. | 2020-07-17 |
| 32669297 | These immunotypes may have implications for the design of therapeutics and vaccines for COVID-19. | 2020-07-17 |
| 32669298 | We performed an online survey among physicians involved in the treatment of mccRCC, and 41 experts responded. […] Questions focused on criteria relevant for treatment decision outside the pandemic and the modifications of systemic therapy during COVID-19. […] The main treatment choice in fit, favourable risk patients outside the pandemic is pembrolizumab/axitinib for 53%, avelumab/axitinib, sunitinib or pazopanib for 13% of experts each. […] In patients responding to established therapies with ICI/ICI or ICI/TKI combinations, most participants modify treatment regimen by extending cycle length, holding one ICI or even both. mccRCC treatment modifications in light of the coronavirus pandemic are variable, with a shift from ICI/ICI to ICI/TKI or TKI monotherapy. | 2020-07-17 |
| 32669360 | To minimise contaminated aerosol generation during CPAP treatment, filters can be attached to expiratory tubing with only a minimal increase in imposed WOB in a non-humidified environment. | 2020-07-17 |
| 32669523 | Traditional Chinese medicine has a history of more than 2,000 years in the prevention and treatment of epidemics and plagues. | 2020-07-17 |
| 32669664 | The genome sequence and protein structure of the 2019-novel coronavirus (nCoV or SARS-CoV-2) were made available in record time, allowing the development of inactivated or attenuated viral vaccines along with subunit vaccines for prophylaxis and treatment. | 2020-07-17 |
| 32669787 | This is particularly true in the current landscape, where efforts to “scale up” mental health and to reduce “treatment gaps” are gaining momentum and where post-pandemic responses are still being formulated. | 2020-07-17 |
| 32669846 | In this narrative paper, we reviewed major neurologic adverse drug reactions (ADRs) and pharmacokinetics of drugs which are routinely used for COVID-19 infection and their potential drug-drug interactions (PDDIs) with common drugs used for the treatment of stroke. | 2020-07-17 |
| 32669866 | In this study, we assessed the characteristics of markers of the liver in patients with COVID-19 to provide new insights in improving clinical treatment. | 2020-07-17 |
| 32669938 | The principal recommendation is that the cancer centre executive committee and the multidisciplinary tumour board always try to find a solution to maintain standard-of-care therapy for all patients with thoracic tumours, using novel approaches to treatment and the adoption of a network approach to care, as needed. | 2020-07-17 |
| 32669941 | The emergence of the covid-19 disease pandemic caused by the 2019 novel coronavirus has required a re-evaluation of treatment practices for clinicians caring for patients with chronic lymphocytic leukemia (cll). […] The American Society for Hematology (ash) has provided a series of recommendations for the treatment of patients with cll during the pandemic, covering a range of topics, including testing for covid-19, cll treatment initiation and selection, use of immunoglobulin therapy, in-person monitoring, and treatment of patients with cll and covid-19. […] We summarize the ash recommendations and discuss their applicability as guidelines for the treatment of cll during the covid-19 pandemic in Canada. | 2020-07-17 |
| 32670066 | Due to its sudden and rapid outbreak, effective treatment for COVID-19 is scarce. | 2020-07-17 |
| 32670071 | Given the extreme importance of the current pandemic caused by COVID-19 and due to the fact that scientists agree that there is no identified treatment, this paper analyzes in detail the treatment of a severe COVID-19 patient with convalescent plasma and drugs based on current guidelines for COVID-19 diagnosis and treatment. | 2020-07-17 |
| 32670273 | With the sudden outbreak of COVID-19 patient worldwide and associated mortality, it is critical to come up with an effective treatment against SARS-CoV-2. […] Recently, it was shown that the treatment with sphingosine-1-phosphate receptor 1 analog, CYM5442, resulted in the significant dampening of the immune response upon H1N1 challenge in mice and improved survival of H1N1 infected mice in combination with an antiviral drug, oseltamivir. | 2020-07-17 |
| 32670297 | We sketch the outlines of five possible scenarios for COVID-19 in medical practice and provide potential treatment options targeting dysregulated endogenous adjuvant activity in severe COVID-19 patients. | 2020-07-17 |
| 32670522 | We report a severe case of COVID-19 in a patient with chronic lymphocytic leukemia and describe primarily the clinical presentation and the challenges encountered in the COVID-19 diagnosis, treatment, and specimens sampling pitfalls. | 2020-07-17 |
| 32670524 | Six patients had pneumonia, and 4 needed oxygen therapy. | 2020-07-17 |
| 32670595 | Pharmacists helped to protect the public from Covid-19 pandemic disease by participating in various initiatives including health education and promotion, medication dispensing, medication reconciliation, medication and patient counselling, training for self-management in current outbreak and emergency preparedness. | 2020-07-17 |
| 32670680 | Notch signaling pathway therapy along with anti-viral agents, interleukin-6 inhibitors, and convalescent serum are possible treatment options to better control the inflammatory state that drives the cardiac damage. | 2020-07-17 |
| 32670785 | In the current paper, we describe our successful treatment of one COVID-19 pneumonia patient case with high mortality risk factors. | 2020-07-17 |
| 32670990 | Clinical and laboratory findings in COVID-19 are unspecific.Chest CT has a diagnostic sensitivity comparable to nasopharyngeal swab RT-PCR assay but lacks specificity.RT-PCR assays on biological specimens, particularly nasopharyngeal swabs, are considered the diagnostic gold standard.Bronchoscopy and bronchoalveolar lavage can help confirm the diagnosis and should be performed in patients in whom diagnostic-driven treatment for COVID-19, such as tocilizumab or remdesivir, is being considered. | 2020-07-17 |
| 32671007 | The median duration of symptom onset to treatment was [1.0 (0.0-4.0) days], the duration of symptom onset to isolation [2.0 (0.0-6.0) days], and the duration of symptom onset to diagnosis [5.0 (2.0-8.0) days]. | 2020-07-17 |
| 32671115 | There is currently no specific treatment or vaccine against COVID-19. […] In this review, we highlight the epidemiology, transmission, symptoms, and treatment of this disease, as well as future strategies to manage the spread of this fatal coronavirus. | 2020-07-17 |
| 32671230 | Methods: We used Google Trends data (1 Jan 2020 - 30 Mar 2020) to investigate the impact of the pandemic and government measures to curb it on people’s concerns, as indexed by changes in search frequency for topics indicating mental distress, social and economic stressors and mental health treatment-seeking. […] Concerns over education and access to medication appear to be particular social stressors. | 2020-07-18 |
| 32671348 | Respiratory therapy laboratory. | 2020-07-17 |
| 32671351 | Current news and social media predictions of ventilator, medication, and personnel shortages are rampant. | 2020-07-17 |
| 32671352 | A subset of patients with coronavirus disease 2019 develop renal failure and require continuous renal replacement therapy. […] We reviewed the available literature to understand the frequency of continuous renal replacement therapy use among patients with coronavirus disease 2019 who required intensive care. […] Observational and randomized studies that report the frequency of continuous renal replacement therapy use in adult patients with coronavirus disease 2019. […] We found that up to 20% of patients admitted to ICUs may require continuous renal replacement therapy. […] Given the high utilization of continuous renal replacement therapy by critically ill patients with coronavirus disease 2019, there may be an urgent need to mobilize inpatient dialysis resources to cope with the anticipated increase in the demand. | 2020-07-17 |
| 32671432 | All of them were admitted to the Infectious Diseases Unit, rather than the Orthopaedic and Traumatology Unit, in order to provide the best measures to prevent the spread of the contagion and to ensure the best treatment for COVID-19. | 2020-07-17 |
| 32671455 | Low-molecular-weight heparin should be chosen as early treatment because of its anti-inflammatory action and its ability to antagonize histones and so defend the endothelium. […] However, several therapeutic possibilities have also been proposed such as fibrinolytic treatment, drugs that target NETs, and complement inhibition. | 2020-07-17 |
| 32671539 | This data could help to minimise delay in treatment by allowing a greater number of elective head and neck cancer operations to proceed. | 2020-07-17 |
| 32671601 | An approved therapy for patients with COVID-19 has yet to emerge; however, there are some medications used in the treatment of SARS-CoV-2 infection globally including hydroxychloroquine, remdesivir, dexamethasone, protease inhibitors, and anti-inflammatory agents. […] This article seeks to review the latest evidence with a view to explaining possible pharmacotherapies for the cardiovascular complications of COVID-19 including acute coronary syndrome, heart failure, myocarditis, arrhythmias, and venous thromboembolism, as well as possible interactions between these medications and those currently administered (or under evaluation) in the treatment of COVID-19. | 2020-07-17 |
| 32671829 | Moreover, clinical trials on the use of zinc alone or in addition to other drugs in the prophylaxis/treatment of COVID-19 are ongoing. […] Thereby, we aim to discuss the rationale for targeting zinc metalloenzymes as a new strategy for the treatment of COVID-19. | 2020-07-17 |
| 32672029 | Rehabilitation that mainly requested by the patients included exercise guidance, dietary instruction, traditional Chinese medicine therapy, physical therapy, and Chinese traditional health exercises. | 2020-07-17 |
| 32672061 | In this review, we summarize peptide and peptide-based therapeutics that target one main entry pathway of SARS-CoV-2, which involves the host ACE2 receptor and viral spike (S) protein interaction. […] Furthermore, we discuss the advantages of peptidomimetics and other potential targets that have been studied using peptide-based therapeutics for COVID-19. | 2020-07-17 |
| 32672430 | They can act as fast tools for the early identification and timely treatment of critical cases since their arrival in the ED. | 2020-07-17 |
| 32672528 | Nonetheless, experimental studies are needed to further assess the potentials of these compounds as possible therapeutics against coronaviruses. | 2020-07-17 |
| 32672860 | In this observational single-center study, TCZ appeared to be useful and safe as immunomodulatory therapy for severe COVID-19 pneumonia. | 2020-07-17 |
| 32672988 | This article examines positive and negative responses toward older adults in the United States during the pandemic and the consequences for older adults and society using data from the pandemic in the United States (and informed by data from other countries) as well as past theorizing and empirical research on views and treatment of older adults. […] Pressing policy issues evident from the treatment of older adults during the pandemic include health care (triaging, elder abuse), employment (layoffs, retirement), and education about ageism, as well as the intersection of ageism with other forms of prejudice (e.g., racism) that cuts across these policies. | 2020-07-17 |
| 32673060 | No effective oral therapy exists for early coronavirus disease 2019 (COVID-19). […] Medication adverse effects occurred in 43% (92 of 212) of participants receiving hydroxychloroquine versus 22% (46 of 211) receiving placebo (P < 0.001). | 2020-07-17 |
| 32673086 | An expanded palliative care team held virtual consultations with families to discuss advance care planning and end-of-life decisions. | 2020-07-17 |
| 32673355 | These findings suggest that, under specific conditions, UVA reduces various pathogens including coronavirus-229E, and may provide a safe and effective treatment for infectious diseases of internal viscera. | 2020-07-17 |
| 32673567 | Because approved drugs and vaccines are limited or not available, new options for COVID-19 treatment and prevention are in high demand. | 2020-07-17 |
| 32673577 | The greatest impact on HIV was estimated to be from interruption to antiretroviral therapy, which could occur during a period of high health system demand. […] For tuberculosis, the greatest impact would be from reductions in timely diagnosis and treatment of new cases, which could result from any prolonged period of COVID-19 suppression interventions. | 2020-07-17 |
| 32673617 | Staged ultrasound-assisted catheter-directed thrombolysis was used for treatment of bilateral pulmonary emboli and the extensive lower extremity deep vein thrombosis while the patient received extracorporeal membrane oxygenation support. | 2020-07-17 |
| 32673651 | An increase in visceral fat area (VFA) by ten square centimeters was associated with a 1.37-fold higher likelihood of ICU treatment and a 1.32-fold higher likelihood of mechanical ventilation (adjusted for age and sex). […] For upper abdominal circumference, each additional centimeter of circumference was associated with a 1.13-fold higher likelihood of ICU treatment and a 1.25-fold higher likelihood of mechanical ventilation. | 2020-07-17 |
| 32673837 | It is observed that the studies pertaining to virology, diagnosis and treatment, clinical features etc. have received highest citations than general studies on epidemiology or pandemic. | 2020-07-17 |
| 32673841 | Only 4% of the patients get cured after 10 days of treatment. | 2020-07-17 |
| 32673995 | Our findings demonstrate that IL6 expression is significant for the prediction of 30-day mortality in hospitalized COVID19 patients and, therefore, may assist in treatment decisions. | 2020-07-17 |
| 32674001 | Pathological data of critical ill COVID-19 patients is essential in the search for optimal treatment options. | 2020-07-17 |
| 32674126 | No therapeutics have yet been proven effective for the treatment of mild-illness caused by SARS-CoV-2. […] We aimed to determine whether early treatment with hydroxychloroquine (HCQ) would be more efficacious than no-treatment for outpatients with mild Covid-19. […] Patients were assigned to receive HCQ (800 mg on day 1, followed by 400 mg once daily for 6 days) or no antiviral treatment (not-placebo controlled). […] Study outcomes were the reduction of viral RNA load in nasopharyngeal swabs up to 7 days after treatment start, patient disease progression using the WHO scale up to 28 days, and time to complete resolution of symptoms. […] This treatment regimen did not reduce risk of hospitalization (7.1%, control vs. […] No relevant treatment-related AEs were reported. | 2020-07-17 |
| 32674170 | Discovering the characteristics of the pediatric COVID-19 disease is important for contributing to the diagnosis and treatment of the disease in this population. | 2020-07-17 |
| 32674191 | After failure of mechanical ventilation because of persistant severe hypoxemia treatment was switched to ECMO which was applicated for 24 days. | 2020-07-17 |
| 32674206 | Disease progression and treatment with hydroxychloroquine and azithromycin ere associated with increased all-cause 30-day mortality in patients with cancer compared with patients either in remission or with no evidence of disease, according to data presented during a 2020 American Society of Clinical Oncology Virtual Scientific Program press briefing. | 2020-07-17 |
| 32674214 | No effective treatment for COVID-19 has been established. | 2020-07-17 |
| 32674217 | No effective treatment for COVID-19 has been established. | 2020-07-17 |
| 32674306 | Overall, 24 (12.5%) children were admitted to paediatric intensive care units, 12 required mechanical ventilation, and three died. […] However, one-eighth of children were admitted to paediatric intensive care units and three died. | 2020-07-18 |
| 32674356 | As such, we suggest that kurarinone may be a useful therapeutic for the treatment of diseases associated with coronavirus infection. | 2020-07-18 |
| 32674481 | Effective treatment of retinal diseases with adeno-associated virus (AAV)-mediated gene therapy is highly dependent on the proportion of successfully transduced cells. […] However, due to inflammatory reactions at high vector doses, adjunctive treatment may be necessary to enhance the therapeutic outcome. […] Hydroxychloroquine and chloroquine are anti-malarial drugs that have been successfully used in the treatment of autoimmune diseases. […] This effect has led to investigations into the potential benefits of these drugs in the treatment of viral infections, including human immunodeficiency virus and severe acute respiratory syndrome coronavirus-2. […] In this review, we explore the immunomodulatory activity of hydroxychloroquine and chloroquine, their impact on viral infections, and their potential to improve the efficacy and safety of retinal gene therapy by reducing AAV-induced immune responses. | 2020-07-18 |
| 32674594 | While improvement in mortality would provide unquestionable evidence about the clinical significance of a treatment, sample sizes for a study evaluating mortality are large and may be impractical, particularly given a multitude of putative therapies to evaluate. […] Outcomes measured at fixed time points, such as a comparison of severity scores between treatment and control at day 14, may risk missing the time of clinical benefit. […] We evaluate statistical power for possible trial endpoints for COVID-19 treatment trials using simulation models and data from two recent COVID-19 treatment trials. […] Time-to-event analysis methods have advantages in the COVID-19 setting, unless the optimal time for evaluating treatment effect is known in advance. | 2020-07-18 |
| 32674654 | Introduction/Objectives: National guidelines underscore the need for improvement in the detection and treatment of mood disorders in the perinatal period. | 2020-07-18 |
| 32674732 | No treatment currently exists for infections caused by CoVs; however, some natural products may represent potential treatment resources, such as those that contain diterpenes. | 2020-07-18 |
| 32674821 | Demographic, biochemical, and radiologic variables, comorbidities, symptoms, and treatment were extracted from electronic medical records. | 2020-07-18 |
| 32674823 | This sudden health emergency severely challenged the Italian Health System, in particular acute care hospitals and intensive care units. | 2020-07-18 |
| 32674827 | Management of the situation requires a systemic response, and post-acute care (PAC) can provide an adequate mix of active treatment, management of associated geriatric syndromes and palliative care, both in the acute phase, and in post-COVID-19 recovery. | 2020-07-18 |
| 32674856 | The COVID-19 epidemic has brought tremendous challenges to the diagnosis and treatment of such patients. […] To coordinate the diagnosis and treatment of infectious disease prevention and spine trauma so as to formulate a rigorous diagnosis and treatment plan and to reduce the disability and mortality of the disease, multidisciplinary collaboration is needed. […] This expert consensus is formulated in order to (1) prevent and control the epidemic, (2) diagnose and treat patients with spine trauma reasonably, and (3) reduce the risk of cross-infection between patients and medical personnel during the treatment. | 2020-07-18 |
| 32674929 | The severity of COVID-19 has resulted in a global rush to find the right antiviral treatment to conquer the pandemic and to treat patients. […] This requires reliable studies to support treatment. | 2020-07-18 |
| 32675009 | Even in the current pandemic, we should not reduce our attention towards the diagnosis and treatment of GDM. | 2020-07-18 |
| 32675044 | Traditional Chinese medicine (TCM) has made contributions to the treatment of COVID-19 because of its efficacy and comprehensive therapeutic theory. […] In this commentary, the advantage, etiology and mechanism of TCM therapy were discussed in the aspect of its functions in reducing the harms brought by COVID-19 to human beings. | 2020-07-18 |
| 32675129 | We also address the potential benefits of experimental therapy, including tocilizumab, a monoclonal antibody that targets interleukin-6 receptors. | 2020-07-18 |
| 32675132 | Nevertheless, there is a subset of patients who require emergency treatment such as aerosol-generating procedures. | 2020-07-18 |
| 32675133 | We describe a 40-year-old woman with severe, persistent macroglossia following prone positioning as part of treatment for COVID-19. […] We used the treatment method of lingual compression with satisfactory results. | 2020-07-18 |
| 32675211 | Many people are dying from coronavirus disease 2019 (COVID-19), but consensus guidance on palliative care in COVID-19 is lacking. […] This new life-threatening disease has put healthcare systems under pressure, with the increased need of palliative care provided to many patients by clinicians who have limited prior experience in this field. […] Therefore, we aimed to make consensus recommendations for palliative care for patients with COVID-19 using the Convergence of Opinion on Recommendations and Evidence (CORE) process. […] Most participants were experts in palliative care, respiratory medicine or critical care medicine. […] This multi-national task force provides consensus recommendations for palliative care for patients with COVID-19 concerning: advance care planning; (pharmacological) palliative treatment of breathlessness; clinician-patient communication; remote clinician-family communication; palliative care involvement in patients with serious COVID-19; spiritual care; psychosocial care; and bereavement care. | 2020-07-18 |
| 32675285 | Moreover, we found that TMPRSS11A activation cleavage occurred before the protein reached the cell surface, as indicated by studies with trypsin digestion to remove cell surface proteins, treatment with cell organelle-disturbing agents to block intracellular protein trafficking, and analysis of a soluble form of TMPRSS11A without the transmembrane domain. | 2020-07-18 |
| 32675436 | In this article, we analyze and report cases of three patients who were admitted to Renmin Hospital, Wuhan University, China, for treating COVID-19 pneumonia in February 2020 and were unresponsive to initial treatment of steroids. […] They were then received titrated steroids treatment based on the assessment of computed tomography (CT) images augmented and analyzed with the artificial intelligence (AI) tool and output. | 2020-07-18 |
| 32675503 | VV ECMO can be utilized as an advanced therapy in select patients with COVID-19 respiratory failure refractory to traditional critical care management and optimal mechanical ventilation. […] Anticipating a need for such therapies during the pandemic, our center created a targeted protocol for ECMO therapy in COVID-19 patients that allows us to provide this life-saving therapy to our sickest patients without overburdening already stretched resources or excessively exposing healthcare staff to infection risk. […] The median duration of VV ECMO therapy for patients who have been decannulated is 12 days (4-18 days). | 2020-07-18 |
| 32675507 | This global survey elucidates the role of pancreatic surgery during the COVID-19 pandemic, regarding patient selection for the surgical and oncological treatment of pancreatic diseases to support clinical decision-making and creating a starting point for further discussion. | 2020-07-18 |
| 32675511 | Cancer surgeons should continue to use their oncologic knowledge to determine the window of opportunity for each surgical procedure, based on tumor biology, preoperative treatment sequencing, and response to systemic therapy, to safely guide patients through this cautious recovery phase. | 2020-07-18 |
| 32675512 | COVID-19 emergency shocked national health systems, subtracting resources from treatment of other diseases. […] The commonest criteria to prioritize surgery were tumor biology (80%), time interval from neoadjuvant therapy (61%), risk of becoming unresectable (57%), and tumor-related symptoms (52%). | 2020-07-18 |
| 32675668 | The “COVID-19 cohort” of patients who received treatment from January 25 to March 27, 2020, was compared with the “control cohort” of patients who received treatment during the same time of year over the past 4 years. […] Operations for the treatment of upper and lower-limb fractures decreased by 23% (from 98.5 ± 14 to 75.9 ± 15.2 per week; p < 0.001) and 20% (from 210.6 ± 29.5 to 168.4 ± 16.9 per week; p < 0.001), respectively, whereas elective joint replacement and ligamentous reconstruction procedures decreased by 74% to 84% (p < 0.001). | 2020-07-18 |
| 32675713 | In the second period, all patients admitted for fracture treatment were screened by RT-qPCR. | 2020-07-18 |
| 32675715 | Adjusted analyses from the largest published studies demonstrate independent effects of systemic glucocorticoids, as well as age and comorbidities with poorer COVID-19 outcomes (SECURE-IBD registry, n = 525; COVID-19 Global Rheumatology Alliance registry, n = 600); biologic or targeted synthetic disease-modifying antirheumatic drug therapy has not been associated with more severe outcomes. | 2020-07-18 |
| 32675717 | Currently, there is a large debate on the use of antimalarials for prophylaxis and treatment of SARS-CoV-2-induced disease based on preclinical in-vitro data, small case series and extrapolation from earlier studies of their effect on intracellular pathogens, including many viruses. […] For SARS-CoV-2 various large studies will provide answers as to whether antimalarials have a place in prophylaxis or treatment of the acute virus infection with SARS-CoV-2 but compelling data are missing so far. | 2020-07-18 |
| 32675771 | No patient required bilevel positive airway pressure or nebulizer use in the emergency department, and none developed acute respiratory distress syndrome, pulmonary embolism, deep venous thrombosis, or a cytokine storm while on therapy for COVID-19. | 2020-07-18 |
| 32676039 | The majority of patients affected by COVID-19 complained only slight symptoms: fatigue, myalgia or cough, but more than 15% of Chinese patients progressed into severe complications, with acute respiratory distress syndrome (ARDS), needing intensive treatment. | 2020-07-18 |
| 32676052 | This may help with early diagnosis, prevention of disease spread, and treatment planning. […] Therefore, clinicians need to be vigilant in the diagnosis and treatment of these patients. | 2020-07-18 |
| 32676080 | Chimeric antigen receptor T cell (CART) therapy, administration of certain T cell-agonistic antibodies, immune check point inhibitors, coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) and Toxic shock syndrome (TSS) caused by streptococcal as well as staphylococcal superantigens share one common complication, that is T cell-driven cytokine release syndrome (CRS) accompanied by multiple organ dysfunction (MOD). […] As a result, there is no specific treatment available to date for CRS, and it is managed only symptomatically to support the deteriorating organ functions and maintain the blood pressure. […] Therefore, we used the superantigen-induced CRS model in HLA-DR3 transgenic mice, that closely mimics human CRS, to delineate the immunopathogenesis of CRS as well as to validate a novel treatment for CRS. | 2020-07-18 |
| 32676257 | By day 4, the patient had marked response to treatment with platelet recovery to 105 K/µL and subsequently discharged by day 5 with complete resolution of symptoms and platelet count of 146 K/µL. | 2020-07-18 |
| 32676299 | In order to contain the spread of COVID-19, China adopted a centralized treatment plan by appointing designated hospitals in each region. […] It was appointed as a provincial COVID-19 designated treatment hospital on January 21, 2020, to provide all COVID-19-related treatments for the city of Shantou. […] To summarize the role of nursing management in transforming a general hospital into a designated hospital for treatment of COVID-19 patients. | 2020-07-18 |
| 32676372 | The lesions of COVID-19 pneumonia distributed mainly in the back-lung segments, which characteristic may light new ideas in clinical treatment and nursing strategy. | 2020-07-18 |
| 32676459 | Healthcare systems across the world had to adapt quickly to mitigate this risk, while continuing to provide potentially lifesaving treatment to patients. […] These care models provide the right treatment, to the right patient, at the right time, in the right place. | 2020-07-18 |
| 32676492 | A positive association of shutdown and social distancing with the fear of losing one’s own or a family members’ life, influenced by a lack of healthcare treatment (p < 0.05), reveals that, due to the decision of shutting down normal activities, people may be experiencing mental and economic stress. | 2020-07-18 |
| 32676677 | Speech therapy should, therefore, not be associated with an increased risk of contamination when implementing standard recommendations. | 2020-07-18 |
| 32676681 | To assess the impact of the lockdown due to coronavirus disease 2019 (COVID-19) on key quality indicators for the treatment of ST-segment elevation myocardial infarction (STEMI) patients. […] Data were obtained from 41 hospitals participating in the prospective Feedback Intervention and Treatment Times in ST-Elevation Myocardial Infarction (FITT-STEMI) study, including 15,800 patients treated for acute STEMI from January 2017 to the end of March 2020. | 2020-07-18 |
| 32676695 | To evaluate the effects of an association therapy of hydroxychloroquine (HY) plus ritonavir/darunavir (RD) or azithromycin (AZ) on QTc intervals. […] Patients underwent an ECG at baseline, then 3 and 7 days after starting therapy. […] A significant increase in median QTc was reported after seven days of therapy in both groups: from 438 to 452 ms in HY/RD patients; from 433 to 440 ms in HY/AZ patients (p = 0.001 for both). 23 patients (21.2%) had a QTc > 500 ms at 7 days. […] The risk of developing a QTc > 500 ms was greater in patients with prolonged baseline QTc values (≥ 440 ms for female and ≥ 460 ms for male patients) (OR 7.10 (95% IC 1.88-26.81); p = 0.004) and in patients with an increase in the QTc > 40 ms 3 days after onset of treatment (OR 30.15 (95% IC 6.96-130.55); p = 0.001). […] Hydroxychloroquine with both ritonavir/darunavir or azithromycin therapy significantly increased the QTc-interval at 7 days. | 2020-07-18 |
| 32676882 | Even if much more data are needed to ascertain the real thrombotic risk of haemophilia A in COVID-19 patients, it’s clear that the FVIII and vWF should be strictly monitored in order to promptly establish an adequate treatment and avoid the onset of thromboembolic events, even fatal, causing many deaths in COVID-19 patients. | 2020-07-18 |
| 32676883 | Here, based on currently available evidence, we review the pathogenic mechanisms of the hypercoagulable state associated with severe cases of COVID-19 to give insights into prevention and treatment of the vascular thrombotic events in COVID-19. | 2020-07-18 |
| 32676935 | Coronavirus disease (COVID-19) symptoms were mild and the patient was managed with no specific treatment and recovered rapidly. […] All findings were consistent with SAT, and treatment with oral prednisone (25 mg/day as the starting dose, gradually tapered) was started. […] Under the corticosteroid therapy, there was progressive resolution of symptoms and signs, and, within 4 weeks, all thyroid functional tests and inflammatory indexes normalized. | 2020-07-18 |
| 32676976 | The two arms of the trial consist of a control therapy (alpha interferon inhalation, 50 µg twice daily; and lopinavir/ritonavir, 400 and 100 mg twice daily, respectively) and a testing therapy (control therapy plus Keguan-1 19.4 g twice daily) by random number table at 1:1 ratio with 24 cases each group. […] After 2-week treatment, adverse events, time to fever resolution, ARDS development, and lung injury on newly diagnosed COVID-19 patients were assessed. […] Keguan-1-based integrative therapy was safe and superior to the standard therapy in suppressing the development of ARDS in COVID-19 patients. | 2020-07-18 |
| 32677007 | On day 10, heparin treatment was replaced by danaparoid sodium, but by day 13, the continued low platelet count made a diagnosis of heparin-induced thrombocytopenia unlikely. | 2020-07-18 |
| 32677081 | Unsurprisingly, there are shortages of supplies and equipment, treatment space and people with the skills to respond to the containment, treatment and prevention of COVID-19. […] Nurses are at the front line of every nation’s response, trying to provide assessment, protection, treatment and prevention as being part of the overwhelming care demand that is occurring. | 2020-07-18 |
| 32677113 | The number of CV events increased by 25 (95% confidence interval [CI]: 8, 42, p=0.005) per 1000 people per year of treatment with hydroxychloroquine alone compared with pretreatment levels and by 201 (95% CI: 145, 256, p<0.001) events per 1000 people per year when individuals took hydroxychloroquine and azithromycin. […] These rates translate to an additional 0.34 (95% CI: 0.11, 0.58) CV events per 1000 patients placed on a 5-day treatment with hydroxychloroquine monotherapy and 2.75 (95% CI: 1.99, 3.51) per 1000 patients on a 5-day treatment with both hydroxychloroquine and azithromycin. […] For females aged 60 to 79 years prescribed hydroxychloroquine, the rate of adverse CV events was 0.92 per 1000 patients on 5 days of therapy, but it increased to 4.78 per 1000 patients when azithromycin was added. | 2020-07-18 |
| 32677114 | As the backbone of the epidemic prevention and control system, the community prevention and control system plays an important role in improving the pattern of disorderly medical treatment, screening suspected patients, preventing the input of pathogens, ensuring residents’ medical needs, stabilizing public sentiment, reducing disease fear, and maintaining residents’ national security. | 2020-07-18 |
| 32677329 | According to our results, at this relatively early point in the pandemic, subjective patterns of recovery of olfactory dysfunction in COVID-19 patients are valuable for our patients, for hypothesis generation and for treatment development. | 2020-07-18 |
| 32677386 | When clinicians desire a CT scan of a patient with COVID-19 to monitor treatment response, a safe method for patient transport is necessary. | 2020-07-18 |
| 32677462 | The median time to come back to treatment of the COV-FA group was 47 days (range 19-72 days). […] Advanced age (≥60 years) was found to be the independent factor that was predictive of time to come back to treatment (p = 0.043). […] Advanced age could be predictive of time to come back to treatment. | 2020-07-18 |
| 32677509 | Improved ability to identify high-risk patients will improve clinicians’ ability to provide appropriate palliative care, including engaging in shared decision-making about life-sustaining therapies. […] Using logistic regression, Palliative Performance Scale was assessed as a predictor of mortality controlling for demographics, comorbidities, palliative care measures and socioeconomic status. […] Improved predictors of mortality can help clinicians caring for patients with COVID-19 to discuss prognosis and provide appropriate palliative care including decisions about life-sustaining therapy. | 2020-07-18 |
| 32677513 | A proper patient selection of patients requiring virtual treatment versus those requiring in-person visits should be considered. | 2020-07-18 |
| 32677533 | Despite these debilitating conditions, no medication to stop the disease progression or vaccination is available till now. | 2020-07-18 |
| 32677545 | We aimed to analyze the interactions of both hydroxychloroquine and chloroquine with SARS-CoV-2 and identify their possible role for the prevention/treatment of COVID-19 by molecular docking studies. | 2020-07-18 |
| 32677557 | In this review, we will provide an overview of COVID-19’s clinical features, and discuss the optimization and treatment of spine pathology during the ongoing global pandemic. | 2020-07-18 |
| 32677591 | We focus on one variable, vitamin D adequacy in the general population, and consider statistics of two sub-populations to propose a possible treatment to improve outcomes. | 2020-07-18 |
| 32677734 | Treatment for COVID-19 is currently predominantly supportive care, focused on appropriate management of respiratory dysfunction. | 2020-07-18 |
| 32677858 | Few studies have examined the prehospital presentation, assessment, or treatment of patients diagnosed with coronavirus disease 2019 (COVID-19). | 2020-07-18 |
| 32677875 | The findings were analyzed separately in patients in intensive care units (ICU) and other departments (non-ICU). | 2020-07-18 |
| 32677879 | To address the issue, a novel datamining method is introduced and applied to repositioning of drugs for hypertension (HT) which is a serious medical condition and needs some improved treatment plans to help treat it. | 2020-07-18 |
| 32677909 | After 18 days of treatment, he was discharged with improved symptoms, lung lesions and negative results of nasopharyngeal swab. […] A combination of patient’s exposure history, clinical manifestations, laboratory tests, and typical imaging findings plays a vital role in making preliminary diagnosis and guide early isolation and treatment. | 2020-07-18 |
| 32677909 | After 18 days of treatment, he was discharged with improved symptoms, lung lesions and negative results of nasopharyngeal swab. […] A combination of patient’s exposure history, clinical manifestations, laboratory tests, and typical imaging findings plays a vital role in making preliminary diagnosis and guide early isolation and treatment. | 2020-07-18 |
| 32677909 | After 18 days of treatment, he was discharged with improved symptoms, lung lesions and negative results of nasopharyngeal swab. […] A combination of patient’s exposure history, clinical manifestations, laboratory tests, and typical imaging findings plays a vital role in making preliminary diagnosis and guide early isolation and treatment. | 2020-07-18 |
| 32677909 | After 18 days of treatment, he was discharged with improved symptoms, lung lesions and negative results of nasopharyngeal swab. […] A combination of patient’s exposure history, clinical manifestations, laboratory tests, and typical imaging findings plays a vital role in making preliminary diagnosis and guide early isolation and treatment. | 2020-07-18 |
| 32677909 | After 18 days of treatment, he was discharged with improved symptoms, lung lesions and negative results of nasopharyngeal swab. […] A combination of patient’s exposure history, clinical manifestations, laboratory tests, and typical imaging findings plays a vital role in making preliminary diagnosis and guide early isolation and treatment. | 2020-07-18 |
| 32677909 | After 18 days of treatment, he was discharged with improved symptoms, lung lesions and negative results of nasopharyngeal swab. […] A combination of patient’s exposure history, clinical manifestations, laboratory tests, and typical imaging findings plays a vital role in making preliminary diagnosis and guide early isolation and treatment. | 2020-07-18 |
| 32677909 | After 18 days of treatment, he was discharged with improved symptoms, lung lesions and negative results of nasopharyngeal swab. […] A combination of patient’s exposure history, clinical manifestations, laboratory tests, and typical imaging findings plays a vital role in making preliminary diagnosis and guide early isolation and treatment. | 2020-07-18 |
| 32677909 | After 18 days of treatment, he was discharged with improved symptoms, lung lesions and negative results of nasopharyngeal swab. […] A combination of patient’s exposure history, clinical manifestations, laboratory tests, and typical imaging findings plays a vital role in making preliminary diagnosis and guide early isolation and treatment. | 2020-07-18 |
| 32677909 | After 18 days of treatment, he was discharged with improved symptoms, lung lesions and negative results of nasopharyngeal swab. […] A combination of patient’s exposure history, clinical manifestations, laboratory tests, and typical imaging findings plays a vital role in making preliminary diagnosis and guide early isolation and treatment. | 2020-07-18 |
| 32677909 | After 18 days of treatment, he was discharged with improved symptoms, lung lesions and negative results of nasopharyngeal swab. […] A combination of patient’s exposure history, clinical manifestations, laboratory tests, and typical imaging findings plays a vital role in making preliminary diagnosis and guide early isolation and treatment. | 2020-07-18 |
| 32677909 | After 18 days of treatment, he was discharged with improved symptoms, lung lesions and negative results of nasopharyngeal swab. […] A combination of patient’s exposure history, clinical manifestations, laboratory tests, and typical imaging findings plays a vital role in making preliminary diagnosis and guide early isolation and treatment. | 2020-07-18 |
| 32677909 | After 18 days of treatment, he was discharged with improved symptoms, lung lesions and negative results of nasopharyngeal swab. […] A combination of patient’s exposure history, clinical manifestations, laboratory tests, and typical imaging findings plays a vital role in making preliminary diagnosis and guide early isolation and treatment. | 2020-07-18 |
| 32677909 | After 18 days of treatment, he was discharged with improved symptoms, lung lesions and negative results of nasopharyngeal swab. […] A combination of patient’s exposure history, clinical manifestations, laboratory tests, and typical imaging findings plays a vital role in making preliminary diagnosis and guide early isolation and treatment. | 2020-07-18 |
| 32677909 | After 18 days of treatment, he was discharged with improved symptoms, lung lesions and negative results of nasopharyngeal swab. […] A combination of patient’s exposure history, clinical manifestations, laboratory tests, and typical imaging findings plays a vital role in making preliminary diagnosis and guide early isolation and treatment. | 2020-07-18 |
| 32677909 | After 18 days of treatment, he was discharged with improved symptoms, lung lesions and negative results of nasopharyngeal swab. […] A combination of patient’s exposure history, clinical manifestations, laboratory tests, and typical imaging findings plays a vital role in making preliminary diagnosis and guide early isolation and treatment. | 2020-07-18 |
| 32677909 | After 18 days of treatment, he was discharged with improved symptoms, lung lesions and negative results of nasopharyngeal swab. […] A combination of patient’s exposure history, clinical manifestations, laboratory tests, and typical imaging findings plays a vital role in making preliminary diagnosis and guide early isolation and treatment. | 2020-07-18 |
| 32677909 | After 18 days of treatment, he was discharged with improved symptoms, lung lesions and negative results of nasopharyngeal swab. […] A combination of patient’s exposure history, clinical manifestations, laboratory tests, and typical imaging findings plays a vital role in making preliminary diagnosis and guide early isolation and treatment. | 2020-07-18 |
| 32677909 | After 18 days of treatment, he was discharged with improved symptoms, lung lesions and negative results of nasopharyngeal swab. […] A combination of patient’s exposure history, clinical manifestations, laboratory tests, and typical imaging findings plays a vital role in making preliminary diagnosis and guide early isolation and treatment. | 2020-07-18 |
| 32677909 | After 18 days of treatment, he was discharged with improved symptoms, lung lesions and negative results of nasopharyngeal swab. […] A combination of patient’s exposure history, clinical manifestations, laboratory tests, and typical imaging findings plays a vital role in making preliminary diagnosis and guide early isolation and treatment. | 2020-07-18 |
| 32677909 | After 18 days of treatment, he was discharged with improved symptoms, lung lesions and negative results of nasopharyngeal swab. […] A combination of patient’s exposure history, clinical manifestations, laboratory tests, and typical imaging findings plays a vital role in making preliminary diagnosis and guide early isolation and treatment. | 2020-07-18 |
| 32677909 | After 18 days of treatment, he was discharged with improved symptoms, lung lesions and negative results of nasopharyngeal swab. […] A combination of patient’s exposure history, clinical manifestations, laboratory tests, and typical imaging findings plays a vital role in making preliminary diagnosis and guide early isolation and treatment. | 2020-07-18 |
| 32677909 | After 18 days of treatment, he was discharged with improved symptoms, lung lesions and negative results of nasopharyngeal swab. […] A combination of patient’s exposure history, clinical manifestations, laboratory tests, and typical imaging findings plays a vital role in making preliminary diagnosis and guide early isolation and treatment. | 2020-07-18 |
| 32677909 | After 18 days of treatment, he was discharged with improved symptoms, lung lesions and negative results of nasopharyngeal swab. […] A combination of patient’s exposure history, clinical manifestations, laboratory tests, and typical imaging findings plays a vital role in making preliminary diagnosis and guide early isolation and treatment. | 2020-07-18 |
| 32677909 | After 18 days of treatment, he was discharged with improved symptoms, lung lesions and negative results of nasopharyngeal swab. […] A combination of patient’s exposure history, clinical manifestations, laboratory tests, and typical imaging findings plays a vital role in making preliminary diagnosis and guide early isolation and treatment. | 2020-07-18 |
| 32677909 | After 18 days of treatment, he was discharged with improved symptoms, lung lesions and negative results of nasopharyngeal swab. […] A combination of patient’s exposure history, clinical manifestations, laboratory tests, and typical imaging findings plays a vital role in making preliminary diagnosis and guide early isolation and treatment. | 2020-07-18 |
| 32677909 | After 18 days of treatment, he was discharged with improved symptoms, lung lesions and negative results of nasopharyngeal swab. […] A combination of patient’s exposure history, clinical manifestations, laboratory tests, and typical imaging findings plays a vital role in making preliminary diagnosis and guide early isolation and treatment. | 2020-07-18 |
| 32677909 | After 18 days of treatment, he was discharged with improved symptoms, lung lesions and negative results of nasopharyngeal swab. […] A combination of patient’s exposure history, clinical manifestations, laboratory tests, and typical imaging findings plays a vital role in making preliminary diagnosis and guide early isolation and treatment. | 2020-07-18 |
| 32677909 | After 18 days of treatment, he was discharged with improved symptoms, lung lesions and negative results of nasopharyngeal swab. […] A combination of patient’s exposure history, clinical manifestations, laboratory tests, and typical imaging findings plays a vital role in making preliminary diagnosis and guide early isolation and treatment. | 2020-07-18 |
| 32677909 | After 18 days of treatment, he was discharged with improved symptoms, lung lesions and negative results of nasopharyngeal swab. […] A combination of patient’s exposure history, clinical manifestations, laboratory tests, and typical imaging findings plays a vital role in making preliminary diagnosis and guide early isolation and treatment. | 2020-07-18 |
| 32677909 | After 18 days of treatment, he was discharged with improved symptoms, lung lesions and negative results of nasopharyngeal swab. […] A combination of patient’s exposure history, clinical manifestations, laboratory tests, and typical imaging findings plays a vital role in making preliminary diagnosis and guide early isolation and treatment. | 2020-07-18 |
| 32677909 | After 18 days of treatment, he was discharged with improved symptoms, lung lesions and negative results of nasopharyngeal swab. […] A combination of patient’s exposure history, clinical manifestations, laboratory tests, and typical imaging findings plays a vital role in making preliminary diagnosis and guide early isolation and treatment. | 2020-07-18 |
| 32677909 | After 18 days of treatment, he was discharged with improved symptoms, lung lesions and negative results of nasopharyngeal swab. […] A combination of patient’s exposure history, clinical manifestations, laboratory tests, and typical imaging findings plays a vital role in making preliminary diagnosis and guide early isolation and treatment. | 2020-07-18 |
| 32677909 | After 18 days of treatment, he was discharged with improved symptoms, lung lesions and negative results of nasopharyngeal swab. […] A combination of patient’s exposure history, clinical manifestations, laboratory tests, and typical imaging findings plays a vital role in making preliminary diagnosis and guide early isolation and treatment. | 2020-07-18 |
| 32677909 | After 18 days of treatment, he was discharged with improved symptoms, lung lesions and negative results of nasopharyngeal swab. […] A combination of patient’s exposure history, clinical manifestations, laboratory tests, and typical imaging findings plays a vital role in making preliminary diagnosis and guide early isolation and treatment. | 2020-07-18 |
| 32677909 | After 18 days of treatment, he was discharged with improved symptoms, lung lesions and negative results of nasopharyngeal swab. […] A combination of patient’s exposure history, clinical manifestations, laboratory tests, and typical imaging findings plays a vital role in making preliminary diagnosis and guide early isolation and treatment. | 2020-07-18 |
| 32677909 | After 18 days of treatment, he was discharged with improved symptoms, lung lesions and negative results of nasopharyngeal swab. […] A combination of patient’s exposure history, clinical manifestations, laboratory tests, and typical imaging findings plays a vital role in making preliminary diagnosis and guide early isolation and treatment. | 2020-07-18 |
| 32677909 | After 18 days of treatment, he was discharged with improved symptoms, lung lesions and negative results of nasopharyngeal swab. […] A combination of patient’s exposure history, clinical manifestations, laboratory tests, and typical imaging findings plays a vital role in making preliminary diagnosis and guide early isolation and treatment. | 2020-07-18 |
| 32677909 | After 18 days of treatment, he was discharged with improved symptoms, lung lesions and negative results of nasopharyngeal swab. […] A combination of patient’s exposure history, clinical manifestations, laboratory tests, and typical imaging findings plays a vital role in making preliminary diagnosis and guide early isolation and treatment. | 2020-07-18 |
| 32677909 | After 18 days of treatment, he was discharged with improved symptoms, lung lesions and negative results of nasopharyngeal swab. […] A combination of patient’s exposure history, clinical manifestations, laboratory tests, and typical imaging findings plays a vital role in making preliminary diagnosis and guide early isolation and treatment. | 2020-07-18 |
| 32677909 | After 18 days of treatment, he was discharged with improved symptoms, lung lesions and negative results of nasopharyngeal swab. […] A combination of patient’s exposure history, clinical manifestations, laboratory tests, and typical imaging findings plays a vital role in making preliminary diagnosis and guide early isolation and treatment. | 2020-07-18 |
| 32677909 | After 18 days of treatment, he was discharged with improved symptoms, lung lesions and negative results of nasopharyngeal swab. […] A combination of patient’s exposure history, clinical manifestations, laboratory tests, and typical imaging findings plays a vital role in making preliminary diagnosis and guide early isolation and treatment. | 2020-07-18 |
| 32677909 | After 18 days of treatment, he was discharged with improved symptoms, lung lesions and negative results of nasopharyngeal swab. […] A combination of patient’s exposure history, clinical manifestations, laboratory tests, and typical imaging findings plays a vital role in making preliminary diagnosis and guide early isolation and treatment. | 2020-07-18 |
| 32677909 | After 18 days of treatment, he was discharged with improved symptoms, lung lesions and negative results of nasopharyngeal swab. […] A combination of patient’s exposure history, clinical manifestations, laboratory tests, and typical imaging findings plays a vital role in making preliminary diagnosis and guide early isolation and treatment. | 2020-07-18 |
| 32677909 | After 18 days of treatment, he was discharged with improved symptoms, lung lesions and negative results of nasopharyngeal swab. […] A combination of patient’s exposure history, clinical manifestations, laboratory tests, and typical imaging findings plays a vital role in making preliminary diagnosis and guide early isolation and treatment. | 2020-07-18 |
| 32677909 | After 18 days of treatment, he was discharged with improved symptoms, lung lesions and negative results of nasopharyngeal swab. […] A combination of patient’s exposure history, clinical manifestations, laboratory tests, and typical imaging findings plays a vital role in making preliminary diagnosis and guide early isolation and treatment. | 2020-07-18 |
| 32677909 | After 18 days of treatment, he was discharged with improved symptoms, lung lesions and negative results of nasopharyngeal swab. […] A combination of patient’s exposure history, clinical manifestations, laboratory tests, and typical imaging findings plays a vital role in making preliminary diagnosis and guide early isolation and treatment. | 2020-07-18 |
| 32677909 | After 18 days of treatment, he was discharged with improved symptoms, lung lesions and negative results of nasopharyngeal swab. […] A combination of patient’s exposure history, clinical manifestations, laboratory tests, and typical imaging findings plays a vital role in making preliminary diagnosis and guide early isolation and treatment. | 2020-07-18 |
| 32677909 | After 18 days of treatment, he was discharged with improved symptoms, lung lesions and negative results of nasopharyngeal swab. […] A combination of patient’s exposure history, clinical manifestations, laboratory tests, and typical imaging findings plays a vital role in making preliminary diagnosis and guide early isolation and treatment. | 2020-07-18 |
| 32677909 | After 18 days of treatment, he was discharged with improved symptoms, lung lesions and negative results of nasopharyngeal swab. […] A combination of patient’s exposure history, clinical manifestations, laboratory tests, and typical imaging findings plays a vital role in making preliminary diagnosis and guide early isolation and treatment. | 2020-07-18 |
| 32677909 | After 18 days of treatment, he was discharged with improved symptoms, lung lesions and negative results of nasopharyngeal swab. […] A combination of patient’s exposure history, clinical manifestations, laboratory tests, and typical imaging findings plays a vital role in making preliminary diagnosis and guide early isolation and treatment. | 2020-07-18 |
| 32677909 | After 18 days of treatment, he was discharged with improved symptoms, lung lesions and negative results of nasopharyngeal swab. […] A combination of patient’s exposure history, clinical manifestations, laboratory tests, and typical imaging findings plays a vital role in making preliminary diagnosis and guide early isolation and treatment. | 2020-07-18 |
| 32677909 | After 18 days of treatment, he was discharged with improved symptoms, lung lesions and negative results of nasopharyngeal swab. […] A combination of patient’s exposure history, clinical manifestations, laboratory tests, and typical imaging findings plays a vital role in making preliminary diagnosis and guide early isolation and treatment. | 2020-07-18 |
| 32677909 | After 18 days of treatment, he was discharged with improved symptoms, lung lesions and negative results of nasopharyngeal swab. […] A combination of patient’s exposure history, clinical manifestations, laboratory tests, and typical imaging findings plays a vital role in making preliminary diagnosis and guide early isolation and treatment. | 2020-07-18 |
| 32677909 | After 18 days of treatment, he was discharged with improved symptoms, lung lesions and negative results of nasopharyngeal swab. […] A combination of patient’s exposure history, clinical manifestations, laboratory tests, and typical imaging findings plays a vital role in making preliminary diagnosis and guide early isolation and treatment. | 2020-07-18 |
| 32677909 | After 18 days of treatment, he was discharged with improved symptoms, lung lesions and negative results of nasopharyngeal swab. […] A combination of patient’s exposure history, clinical manifestations, laboratory tests, and typical imaging findings plays a vital role in making preliminary diagnosis and guide early isolation and treatment. | 2020-07-18 |
| 32677909 | After 18 days of treatment, he was discharged with improved symptoms, lung lesions and negative results of nasopharyngeal swab. […] A combination of patient’s exposure history, clinical manifestations, laboratory tests, and typical imaging findings plays a vital role in making preliminary diagnosis and guide early isolation and treatment. | 2020-07-18 |
| 32677909 | After 18 days of treatment, he was discharged with improved symptoms, lung lesions and negative results of nasopharyngeal swab. […] A combination of patient’s exposure history, clinical manifestations, laboratory tests, and typical imaging findings plays a vital role in making preliminary diagnosis and guide early isolation and treatment. | 2020-07-18 |
| 32677909 | After 18 days of treatment, he was discharged with improved symptoms, lung lesions and negative results of nasopharyngeal swab. […] A combination of patient’s exposure history, clinical manifestations, laboratory tests, and typical imaging findings plays a vital role in making preliminary diagnosis and guide early isolation and treatment. | 2020-07-18 |
| 32677909 | After 18 days of treatment, he was discharged with improved symptoms, lung lesions and negative results of nasopharyngeal swab. […] A combination of patient’s exposure history, clinical manifestations, laboratory tests, and typical imaging findings plays a vital role in making preliminary diagnosis and guide early isolation and treatment. | 2020-07-18 |
| 32677909 | After 18 days of treatment, he was discharged with improved symptoms, lung lesions and negative results of nasopharyngeal swab. […] A combination of patient’s exposure history, clinical manifestations, laboratory tests, and typical imaging findings plays a vital role in making preliminary diagnosis and guide early isolation and treatment. | 2020-07-18 |
| 32677909 | After 18 days of treatment, he was discharged with improved symptoms, lung lesions and negative results of nasopharyngeal swab. […] A combination of patient’s exposure history, clinical manifestations, laboratory tests, and typical imaging findings plays a vital role in making preliminary diagnosis and guide early isolation and treatment. | 2020-07-18 |
| 32677909 | After 18 days of treatment, he was discharged with improved symptoms, lung lesions and negative results of nasopharyngeal swab. […] A combination of patient’s exposure history, clinical manifestations, laboratory tests, and typical imaging findings plays a vital role in making preliminary diagnosis and guide early isolation and treatment. | 2020-07-18 |
| 32677909 | After 18 days of treatment, he was discharged with improved symptoms, lung lesions and negative results of nasopharyngeal swab. […] A combination of patient’s exposure history, clinical manifestations, laboratory tests, and typical imaging findings plays a vital role in making preliminary diagnosis and guide early isolation and treatment. | 2020-07-18 |
| 32677909 | After 18 days of treatment, he was discharged with improved symptoms, lung lesions and negative results of nasopharyngeal swab. […] A combination of patient’s exposure history, clinical manifestations, laboratory tests, and typical imaging findings plays a vital role in making preliminary diagnosis and guide early isolation and treatment. | 2020-07-18 |
| 32678017 | No effective treatment has been discovered to date. […] We note that the intravenous infusion of CP and MSCs for the treatment of severe COVID-19 patients may have synergistic characteristics in inhibiting cytokine storm, promoting the repair of lung injury, and recovering pulmonary function. | 2020-07-18 |
| 32678040 | Demographic, clinical, radiographic, and laboratory measures; treatment; proximate causes of death; and 14-day and 28-day mortality are described. | 2020-07-18 |
| 32678049 | Further, routine sterile procedures in the wards and intensive care units were video recorded, and the footage was discussed by the infection control team and the personnel involved in the videos. | 2020-07-18 |
| 32678060 | ECHO (Extension for Community Healthcare Outcomes), a videoconferencing peer learning application, engaged health care providers across Missouri in the treatment and management of complex COVID-19-positive patients. | 2020-07-18 |
| 32678371 | To plan for a proactive approach to support patients traveling for their treatment during the COVID-19 pandemic, a network of oncology hospitals worked within existing collaborative agreements to define policies and procedures to transition care for patients living in communities in close proximity to a member institution. […] These efforts led to patients’ abilities to continue treatment in their local community, ensuring continuity of cancer care. | 2020-07-18 |
| 32678432 | In this Viewpoint, we summarize recent evidence for the role of neutrophils in the pathogenesis of COVID-19 and propose CXCR2 inhibition as a promising treatment option to block neutrophil recruitment and activation. | 2020-07-18 |
| 32678695 | There is an urgent need to develop vaccines against the virus, and both convalescent plasma and immune globulin are currently in clinical trials for treatment of patients with COVID-19. | 2020-07-18 |
| 32678815 | Provide a timely, rigorous, and continuously updated summary of the evidence on the role of lopinavir/ritonavir in the treatment of patients with COVID-19. […] We searched for randomized trials and non-randomized studies evaluating the effect of lopinavir/ritonavir versus placebo or no treatment in patients with COVID-19. | 2020-07-18 |
| 32678882 | Kidney graft recipients receiving immunosuppressive therapy may be at heightened risk for coronavirus disease 2019 (Covid-19) and adverse outcomes. […] In the hospitalized group, tacrolimus dosage was reduced in 46% of patients and mycophenolate mofetil (MMF) therapy was stopped in 61% of patients. | 2020-07-18 |
| 32678948 | We aimed to identify risk factors for COVID-19 severity and assess outcomes in patients where COVID-19 complicated the treatment of their haematological disorder. […] Among patients, 82% were on systemic anti-cancer therapy (SACT) at the time of COVID-19 diagnosis. […] Delay or modification of therapy should be considered on an individual basis. […] Long-term follow-up studies in larger patient cohorts are required to assess the efficacy of treatment strategies employed during the pandemic. | 2020-07-18 |
| 32678949 | Should patients develop coronavirus disease (COVID-19) pneumonia requiring hospital admission for treatment of hypoxia, the risk for thromboembolic complications increases greatly. | 2020-07-18 |
| 32678978 | A rush to find a cure prompted re-evaluation of a range of existing therapeutics vis-à-vis their potential role in treating COVID-19, placing a premium on analytical tools capable of supporting such efforts. | 2020-07-18 |
| 32679055 | Combination of host-directed drugs with direct acting antivirals underscore further validation in more physiological models, yet they open up interesting avenues for the treatment of COVID-19. | 2020-07-18 |
| 32679111 | The reduced number of admissions during this period is likely to have resulted in increases in out-of-hospital deaths and long-term complications of myocardial infarction and missed opportunities to offer secondary prevention treatment for patients with coronary heart disease. | 2020-07-18 |
| 32679150 | Due to scarcity of the suitable treatment strategy, the present study was undertaken to explore host protein(s) targeted by potent repurposed drug(s) in COVID-19. | 2020-07-18 |
| 32679155 | Further work is required to understand the mechanism of increased thrombosis and the benefit of aggressive antithrombotic therapy in selected cases. | 2020-07-18 |
| 32679328 | Additionally, we speculate the possible mechanisms of polysaccharides anti-SARS-CoV-2, and propose the strategy of loading S or N protein from coronavirus onto polysaccharide capped gold nanoparticles vaccine for COVID-19 treatment. | 2020-07-18 |
| 32679422 | Although a spesific drug has not been found yet, the medications currently in use for other indications, whose pharmacokinetic- pharmacodynamic properties and toxic doses are already known; are included in the treatment practice of COVID-19. […] Therefore, we think that Proton Pump Inhibitors (PPI’s) with similar mechanisms of action may also be involved in COVID-19 treatment and prophylaxis. | 2020-07-18 |
| 32679425 | This hypothesis may provide a new idea for future treatment of COVID-19 male patients with reproductive function injury, and it can also prompt medical staff and patients to consciously check their reproductive function. | 2020-07-18 |
| 32679506 | High viral loads are found at the sewage pipeline or at the entrance of wastewater treatment plants from cities where the number of COVID-19 cases are significant. | 2020-07-18 |
| 32679582 | Since data regarding the epidemiologic and clinical characteristics in neonates and children developing coronavirus disease 2019 (COVID-19) are scarce and originate mainly from one country (China), we reviewed all the current literature from 1 December 2019 to 7 May 2020 to provide useful information about SARS-CoV2 viral biology, epidemiology, diagnosis, clinical features, treatment, prevention, and hospital organization for clinicians dealing with this selected population. […] IMPACT: Children usually develop a mild form of COVID-19, rarely requiring high-intensity medical treatment in pediatric intensive care unit.Vertical transmission is unlikely, but not completely excluded.Children with confirmed or suspected COVID-19 must be isolated and healthcare workers should wear appropriate protective equipment.Some clinical features (higher incidence of fever, vomiting and diarrhea, and a longer incubation period) are more common in children than in adults, as well as some radiologic aspects (more patchy shadow opacities on CT scan images than ground-glass opacities). […] Supportive and symptomatic treatments (oxygen therapy and antibiotics for preventing/treating bacterial coinfections) are recommended in these patients. | 2020-07-18 |
| 32679775 | Therapeutic strategies for the treatment of any severe disease are based on the discovery and validation of druggable targets. | 2020-07-19 |
| 32679784 | Accordingly, a number of clinical trials aiming to determine the efficacy of administration of vitamin D and its metabolites for treatment of these diseases have been conducted with variable outcomes. | 2020-07-19 |
| 32680440 | This commentary adopts a health information management lens to focus on aspects of data in one of the studies (investigating the use of hydroxychloroquine or chloroquine with or without a macrolide for treatment of COVID-19). | 2020-07-19 |
| 32680520 | Increasing access to safe and effective opioid agonist treatment (OAT) and other harm reduction services during this pandemic is critical to reduce risk. | 2020-07-19 |
| 32680602 | The only literature relevant to the treatment of Coronavirus disease has surfaced from Traditional Chinese Medicine (TCM). | 2020-07-19 |
| 32680780 | Cross-sectional survey experiment in which participants read 6 scenarios, each stating that they had a 3-day supply of a particular medication remaining. […] Participants reported whether they would go to a pharmacy, have a medication delivered, or restrict the use of each medication. […] They reported their perceptions and experiences with COVID-19, health risk factors, preferences for more or less care (medical maximizer-minimizer), medication attitudes (beliefs about medicines questionnaire), health literacy, prescription insurance status, and demographics. […] Participants most often reported that they would go to the pharmacy to obtain each medication (ranging from tramadol 48.9% to insulin 64.9%) except for zolpidem, which they were most likely to restrict (45.4%). | 2020-07-19 |
| 32680828 | Finally, as a clinical community we need to drive a shift in culture towards measurement of patient quality of life as a marker of treatment effectiveness. | 2020-07-19 |
| 32680888 | Palliative care (PC) is centred on effective symptom control, promotion of quality of life, complex decision-making, and holistic care of physical, psychological, social and spiritual health. | 2020-07-19 |
| 32680889 | With only limited palliative care-specific literature and no time to set up and evaluate pilots, we had to get on and set up a prototype ‘virtual visits’ model, retro-fitting guidance and a supporting ethical framework. […] Unsurprisingly, it appears clear that a ‘one-size-fits-all’ mentality is a poor fit for the individualised needs of the heterogeneous palliative care population. | 2020-07-19 |
| 32680896 | Correcting hypoperfusion and treating the underlying process are fundamental aspects of treatment. | 2020-07-19 |
| 32680910 | Biopsy diagnosis informed treatment and prognosis in all patients. | 2020-07-19 |
| 32681141 | Twenty (10.99%) patients out of the 182 were detected to be SARS-CoV-2 RNA positive (re-positives), although none showed any clinical symptomatic recurrence, indicating that COVID-19 responds well to treatment. | 2020-07-19 |
| 32681385 | In patients with advanced disease, tumor growth control, and sometimes also syndrome control are the main goals of systemic therapy. | 2020-07-19 |
| 32681398 | The MISS-HP is a reliable and valid measure of moral injury symptoms in health professionals that can be used in clinical practice to screen for MI and monitor response to treatment, as well as when conducting research that evaluates interventions to treat MI in HPs. | 2020-07-19 |
| 32681447 | There is no registered drug for the treatment of virus infections in cattle and we are limited to supportive therapy and preventative measures. […] This paper will cover epidemiology, taxonomy, pathogenesis, clinical signs, diagnosis, therapy, economic impact and prevention of coronavirus infections in cattle. | 2020-07-19 |
| 32681497 | Iron chelation represents a pillar in the treatment of iron overload. […] Herein, we analyse the pathogenic role of ferritin and iron during SARS-CoV-2 infection and propose iron depletion therapy as a novel therapeutic approach in the COVID-19 pandemic. | 2020-07-19 |
| 32681537 | Intense efforts are underway to evaluate potential therapeutic agents for the treatment of COVID-19. […] This is important due to the harm-benefit ratios that may be encountered when treating COVID-19, which can depend on the stage of the disease, when therapy is administered and underlying clinical factors in individual patients. | 2020-07-19 |
| 32681716 | Given the preponderance of COVID-19 related mortality in elderly males, additional testing for gonadal function and treatment with T may be merited. | 2020-07-19 |
| 32681752 | Furthermore, we noticed a significant increase in the average complexity of cases presenting to the ED in 2020, as proven by the increased need for biopsies and systemic therapy. | 2020-07-19 |
| 32681756 | Each patient received antiviral therapy based on the latest updated version of local protocol at the time of admission. | 2020-07-19 |
| 32681950 | The situation of the COVID-19 pandemic reminds us that we permanently need high-value flexible solutions to urgent clinical needs including simplified diagnostic technologies suitable for use in the field and for delivering targeted therapeutics. | 2020-07-19 |
| 32681968 | In the current time where we face a COVID-19 pandemic, there is no vaccine or effective treatment at this time. | 2020-07-19 |
| 32681986 | In the absence of targeted therapy and a reported 5.5% case fatality rate in the United States, treatments preventing rapid cardiopulmonary failure are urgently needed. | 2020-07-19 |
| 32681989 | Retrospective observational study of children 1 month to 21 years admitted March 14 to May 2, 2020, to 9 New York City pediatric intensive care units (PICUs) with severe acute respiratory syndrome coronavirus 2 infection. […] Twelve patients (17%) met severe sepsis criteria; 14 (20%) required vasopressor support; 21 (30%) developed acute respiratory distress syndrome (ARDS); 9 (12.9%) met acute kidney injury criteria; 1 (1.4%) required renal-replacement therapy, and 2 (2.8%) had cardiac arrest. […] For treatment, 27 (38.6%) patients received hydroxychloroquine; 13 (18.6%) remdesivir; 23 (32.9%) corticosteroids; 3 (4.3%) tocilizumab; and 1 (1.4%) anakinra; no patient was given immunoglobulin or convalescent plasma. | 2020-07-19 |
| 32682303 | Here we report a novel reason for suicide and seemingly COVID-19-related - negligence in getting treatment by Bangladeshi healthcare providers. | 2020-07-19 |
| 32682342 | COVID-19 therapy was given to 10 (34.5%) patients. | 2020-07-19 |
| 32682360 | New treatment regimens for COVID-19, which threatened the world recently, continue to be investigated. […] Although some of the treatments are promising, it is thought to be early to clearly state that there is definitive treatment. […] Experiences and treatment protocols studies coming from the centers are still very important. […] The aim of this study is to evaluate factors affecting the treatment process in the first cases followed in our clinic. […] Early treatment and early admission to the hospital can be crucial for the better treatment process. […] Combination therapy with azithromycin may be preferred in the first treatment choice because it can shorten the length of hospital stay. | 2020-07-20 |
| 32682440 | These findings open new avenues for host-directed therapies in patients with symptomatic SARS-CoV-2 infection and might in addition to antiviral treatment be enough to curb the currently unacceptably high morbidity and mortality associated with COVID-19. | 2020-07-20 |
| 32682444 | Is it safe to use “medications” used in the treatment of COVID-19 during antenatal, perinatal, postnatal, and breastfeeding? | 2020-07-20 |
| 32682454 | Therefore, we should be watchful, searching for early evidence of neurological insults and promoting clinical protocols to investigate them. | 2020-07-20 |
| 32682460 | Mental health concerns have been addressed via the public mental health response and by adapting mental health services, mostly focusing on infection control, modifying access to diagnosis and treatment, ensuring continuity of care for mental health service users, and paying attention to new cases of mental ill health and populations at high risk of mental health problems. | 2020-07-20 |
| 32682575 | Anecdotal evidence suggests that the modulation of systemic immune responses may have a potential role in the treatment of patients with COVID-19. […] Given the importance of the issue and the lack of therapeutic treatment or vaccine; anti-cytokine therapy such as IL-6, TNFα and IL-1 antagonists have been suggested for the alleviation of hyper-inflammation status in these patients. | 2020-07-20 |
| 32682653 | On 23rd March, the UK Government announced a nationwide lockdown in response to the COVID-19 pandemic, resulting in the unequivocal and absolute cessation of all elective dental treatment. […] With much conflicting evidence on best practice to deliver safe treatment comprising of emergency dento-alveolar surgery, this paper describes the protocols which were undertaken to successfully set up a novel Urgent Dental Care Centre (UDCC) service within a short timeframe. […] We present patient data from referral through to treatment for the entire ten-week period of operation. […] Our UDCC received 1,311 referrals within a 10-week period, with 884 patients being accepted for treatment. […] The majority of treatment delivered in this emergency setting was surgical dento-alveolar procedures (84%). […] Sixteen per cent of patients attended for trauma, first stage restorative treatment for teeth and postoperative complications. […] Our results advocate that our unique UDCC is efficient and provides appropriate patient access and outcomes for those most in need of urgent dental treatment in the face of a pandemic. | 2020-07-20 |
| 32682660 | Because orthodontic treatment involves a large population who need routine return-visits, it was significantly affected and suspended because of the COVID-19 pandemic and the shutdown of the dental clinics and hospitals. […] The close proximity between the practitioners and the patients, and the generation of droplets and aerosols that contain saliva and blood during treatment further increase the risks of transmission. | 2020-07-20 |
| 32682671 | The clinical features and subsequent medical treatment, combined with the impact of a global pandemic, require specific nutritional therapy in hospitalised adults. | 2020-07-20 |
| 32682787 | The emergence of the global pandemic caused by novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has put a challenge to identify or derive the therapeutics for its prevention and treatment. | 2020-07-20 |
| 32682788 | Scientists are endeavoring across the world to find effective therapy to combat COVID 19. […] We have also discussed the in-line treatment strategies, preventive measures, and vaccines to combat the emergence of COVID-19. | 2020-07-20 |
| 32683039 | The article culminates with the therapeutics opportunities based on these pathways. | 2020-07-20 |
| 32683212 | To assess efficacy and safety of chloroquine (CQ)/hydroxychloroquine (HCQ) for treatment or prophylaxis of COVID-19 in adult humans. […] Low and moderate risk of bias studies suggest that treatment of hospitalized COVID-19 with CQ/HCQ may not reduce risk of death, compared to standard care. | 2020-07-20 |
| 32683273 | Overall, 30% of patients reported consequences for their oncological treatment or follow-up. […] Among patients with delay and discontinuation of treatment, 55% and 63% of patients, respectively, were (very) concerned about these consequences of the COVID-19 pandemic. | 2020-07-20 |
| 32683296 | Currently, there is no vaccine or approved treatment for this infectious virus so the invention of an efficient vaccine is certainly a high priority. | 2020-07-20 |
| 32683304 | According therapy groups there was significant difference between the groups regarding some variables: patients using ocrelizumab are most concerned about COVID-19; patients using interferon beta 1a i.m. statistically more often have frequent changes in their mood, memory problems, poor appetite, feeling of nausea or upset stomach and patients on fingolimod have bigger afraid of coming to regular visits. | 2020-07-20 |
| 32683373 | Hospitals must be reorganized in order to create a cancer hub that is free of infection, allowing for the safe treatment of patients. | 2020-07-20 |
| 32683660 | Basal-bolus insulin therapy is a safe and effective intervention for the management of hyperglycaemia in hospitalised patients. | 2020-07-20 |
| 32683801 | Several treatment modalities, including the utilization of mechanical ventilation (MV), antivirals, immune-modulating drugs, or other agents, may present promising results in reducing the symptoms of COVID-19, particularly in severe cases. | 2020-07-21 |
| 32683948 | Our world and everything around have changed, our surgical practicehas changed, our life has changed, but Intensive Care Units (ICU)in WestchesterMedical center in Valhalla, NY, continue to care for the sickest of thesickest. | 2020-07-21 |
| 32684101 | Monitoring NLR, T lymphocytes, and subsets would help physicians with the proper diagnosis and treatment of COVID-19. | 2020-07-21 |
| 32684122 | The first line of BrS therapy remains an implantable cardioverter defibrillator (ICD), although radiofrequency catheter ablation has been shown to be an effective option in patients with contraindications for an ICD. […] Aggressive antipyretic therapy and regular ECG monitoring until fever resolves are current recommendations to help reduce the arrhythmic risk in these COVID-19 patients. […] In this review, we summarise the current knowledge on the epidemiology, pathophysiology, genetics, clinical diagnosis, risk stratification and treatment of patients with BrS, with special emphasis on COVID-19 comorbidity. | 2020-07-21 |
| 32684166 | Due to a lack of data, no consensus has been reached about the best practices for the diagnosis and treatment of cancer patients. | 2020-07-21 |
| 32684205 | As the ability of treating coronavirus disease 2019 (COVID-19) improves, the theory and method of diagnosis and treatment of COVID-19 need to be further enriched and perfected. […] In the clinical treatment of COVID-19, the theoretical system of “three syndromes and three methods” for treating critical diseases based on syndrome differentiation by integrated traditional Chinese medicine (TCM) and Western medicine has been recognized by the majority of clinical respiratory and critical disease experts. […] Xuebijing injection, which was developed based on “three syndromes and three methods”, has been repeatedly recommended in the national diagnosis and treatment guidelines. […] In order to facilitate the clinical practitioners better understanding the “three syndromes and three methods”, and apply the theory into the treatment of COVID-19, Expert opinion on diagnosis and treatment of coronavirus disease 2019 with traditional Chinese medicine based on “three syndromes and three methods” was organized by experts from China Association of Integrative Medicine Emergency Medicine Committee, which could make references for clinical practice. | 2020-07-21 |
| 32684206 | The main contents include the possible mechanism of CP, the evidence of CP in the treatment of COVID-19 patients, the safety of clinical application of CP and the main factors affecting the clinical effect of CP, which may provide some basis for clinicians to choose CP for the treatment of adult patients with COVID-19. | 2020-07-21 |
| 32684207 | Coronavirus disease 2019 (COVID-19) is sweeping the world with strong infectivity and high mortality, but by now, we still lack specific treatment. […] Cellular immunity plays a crucial role in the body’s elimination of coronavirus, so it is necessary to study cellular immunity on the basis of plasma therapy. […] This article summarizes the infusion safety, therapeutic mechanism of all above components, and their effects on immunologic derangement and excessive inflammatory response, in order to provide an alternative reference for the treatment of COVID-19. | 2020-07-21 |
| 32684210 | The Chinese keyword co-occurrence, clustering and highlighted words analysis showed that the main research areas of severe COVID-19 included clinical features, traditional Chinese medicine treatment, medical imaging, integrated traditional Chinese and Western medicine treatment and so on; nucleic acid detection, clinical features and diagnosis, plague theory and etiology mechanism, traditional Chinese medicine and integrated Chinese and Western medicine treatment, severe COVID-19 combined with diabetes and prognosis research will become future research trends; keyword cluster analysis showed that severe COVID-19, combined chronic underlying diseases, CT imaging characteristics will also become new trends in the field of research. […] Domestic research focuses on the diagnosis and treatment of severe cases, while foreign countries attach importance to epidemic response and prevention. | 2020-07-21 |
| 32684211 | HR decreased gradually after sedation treatment, which was significantly lower after 12 hours of sedation than that before sedation, and HR in dexmedetomidine group was significantly lower than that in control group after 12 hours of sedation (bpm: 84.0±13.9 vs. | 2020-07-21 |
| 32684225 | With reference to the customs inspection and quarantine regulations, in accordance with the Diagnosis and treatment of pneumonia caused by novel coronavirus (trial version 3) for mulated by the National Health Commission of the People’s Republic of China and the Novel coronavirus infected pneumonia port control and technology plan (first version) formulated by the General Administration of Customs, combined with the actual situation of cruise ships, the medical investigation team developed the inspection standards, including door-to-door inspections, temperature measurement and epidemiological investigations on all persons on board of the cruise ship. | 2020-07-21 |
| 32684351 | Scientists have taken great efforts to investigate the effective methods for the treatment of COVID-19. […] In this article, we reviewed the current options for COVID-19 therapy including small molecules such as Remdesivir, Favipiravir, Lopinavir/Ritonavir etc, peptide inhibitors of ACE2, Traditional Chinese Medicines and Biologics such as SARS-CoV-2-specific neutralizing antibodies, mesenchymal stem cells and vaccines etc. […] The therapeutic effect of these antiviral drugs is summarized and compared, hoping to provide some ideas for clinical options of COVID-19 treatment and also provide experiences for the life-threatening virus diseases in the future. | 2020-07-21 |
| 32684483 | Fifty-four registered cellular therapy trials were identified and included for analysis. | 2020-07-21 |
| 32684674 | The recent spread of severe acute respiratory syndrome coronavirus (SARS-CoV2) and its associated coronavirus disease has gripped the entire international community and has caused widespread public health concerns due to the unavailability of treatment to this deadly disease. | 2020-07-21 |
| 32684717 | For each centre, we reported the number, diagnosis, co-morbidities, treatment, hospital course, complications and outcomes of confirmed COVID 19 patients. […] The COVID-19 raised many important issues, such as the optimal management of patients requiring the treatment of conventional diseases during a pandemic. | 2020-07-21 |
| 32684752 | Perinatal-neonatal departments should cooperate closely and take integrated approaches, and neonatal intensive care units (NICU) should prepare emergency plans for the coronavirus disease 2019 (COVID-19) as far as possible, so as to ensure the optimal management and treatment of potential victims. […] During the epidemic of COVID-19, the emergency response plan for the NICU should be based on the actual situation, including diagnosis, isolation, and treatment, as well as available equipment and staffing, and take into account the psychosocial needs of the families and neonatal care staff. | 2020-07-21 |
| 32684754 | There is currently no specific antiviral treatment against the SARS-CoV-2 virus. […] Supportive treatment is recommended in children with a mild course, and some treatments are recommended in children with comorbidities or in children who are observed to have a more severe course. | 2020-07-21 |
| 32685022 | At present, various diagnostic kits to test for SARS-CoV-2 are available for use to initiate appropriate treatment faster and to limit further spread of the virus. […] Given the urgency of the outbreak, we focus here on recent advances in the diagnostics, treatment, and vaccine development for SARS-CoV-2 infection, helping to guide strategies to address the current COVID-19 pandemic. | 2020-07-21 |
| 32685042 | Corticosteroids are a mainstay of treatment in Covid-19 infection, therefore it is important to consider all aspects involved by high doses, including metabolic adverse reactions especially in diabetic patients. | 2020-07-21 |
| 32685049 | After the initiation of treatment, the patient developed hyponatremia. | 2020-07-21 |
| 32685191 | In conclusion from the perspective of the ACE2 receptor, COVID-19 prevention and treatment are distinctly different. | 2020-07-21 |
| 32685234 | N. sativa could be used as an adjuvant therapy along with repurposed conventional drugs to manage the patients with COVID-19. | 2020-07-21 |
| 32685259 | Oncology patients are especially vulnerable to infection due to the underlying disease and the type of therapy received. | 2020-07-21 |
| 32685262 | Our goal should be to maintain high standards in the treatment of cardiovascular diseases, reducing the risk of esposure to Covid-19 for patients and healthcare professionals. | 2020-07-21 |
| 32685300 | Currently, there is no effective treatment available and the data are evolving through continuous clinical trials and ongoing research. […] Later, their clinical course worsened despite ongoing treatment with multiple medications such as hydroxychloroquine and azithromycin until they were started on tocilizumab. | 2020-07-21 |
| 32685301 | Patients with acute kidney insufficiency showed a more severe disease course, and these patients ended up more in intensive care units. […] Particular attention should be paid to those with already established kidney disease, such as chronic kidney disease, or renal transplant recipients, as these patients are already on immunosuppressive therapy. | 2020-07-21 |
| 32685302 | We report the case of a polymerase chain reaction (PCR)-confirmed COVID-19 in a Hispanic male with no past medical history who presented to the ED with upper respiratory tract symptoms including shortness of breath and cough, requiring continuous positive airway pressure (CPAP) therapy. | 2020-07-21 |
| 32685326 | Interestingly, despite intensive treatment, the patient developed sudden complications during the second week of his hospitalization. […] The symptoms started to resolve on pharmacological treatment and supplemental noninvasive oxygen supply over the next weeks. | 2020-07-21 |
| 32685374 | The neonate’s medical history indicated no close contact except with family members and hospital treatment staffs, but the RT-PCR test results of all family members were also negative. | 2020-07-21 |
| 32685484 | The identification of viral pathogenic mechanisms is important for further developing effective drugs and targeted clinical treatment methods. […] The delayed revelation of viral infectious mechanisms is currently one of the technical obstacles in the prevention and treatment of infectious diseases. | 2020-07-21 |
| 32685610 | In summary, the 10 million older adults in rural communities in the United States may face challenges with obtaining critical care treatment due to the increased need of ICU beds during the COVID-19 pandemic. | 2020-07-21 |
| 32685653 | Definitive diagnosis and treatment occurred only after completion of the impending fracture. | 2020-07-21 |
| 32685691 | To address the epidemic, it is necessary not only to take good prevention and treatment measures, but also to have effective and targeted public health emergency governance. | 2020-07-21 |
| 32685880 | This forum discusses the lungs as the epicenter for the hemostatic issues, puts forward a proposal for staging COVID-19 coagulopathy based on available diagnostic markers, and suggest considering current and future treatment options based on these different stages. | 2020-07-21 |
| 32685905 | We recommend clinicians monitor platelet counts closely during heparin therapy, with a low threshold to evaluate for HIT. | 2020-07-21 |
| 32685969 | A major error is found in the article: Early Outpatient Treatment of Symptomatic, High_Risk Covid-19 Patients that Should be Ramped-Up Immediately as Key to the Pandemic Crisis, by Harvey Risch, which highlights how the work by Prof. | 2020-07-21 |
| 32686011 | Due to between-study differences in treatment strategy and reporting methods the results were not pooled and findings of the current review were presented in a narrative manner. […] Management is performed at home and consists of exercise, proper nutrition, physical therapy and use of corrective and assistive orthotics. | 2020-07-21 |
| 32686059 | Vitamin K-Antagonists (VKAs) are the treatment of choice in patients with indications other than atrial fibrillation and venous thromboembolism. […] Moreover, some patients still assume VKAs refusing to change their therapy when direct oral anticoagulants (DOACs) are properly indicated. | 2020-07-21 |
| 32686219 | In preclinical models, senolytics delay, prevent or alleviate frailty, cancers and cardiovascular, neuropsychiatric, liver, kidney, musculoskeletal, lung, eye, haematological, metabolic and skin disorders as well as complications of organ transplantation, radiation and cancer treatment. | 2020-07-21 |
| 32686245 | The pandemic has affected the management of psoriasis not only for those who are under treatment but also for those who are about to begin a new therapy to control their disease. […] The treatment approach should be personalized, considering the advantages and disadvantages for each case separately. | 2020-07-21 |
| 32686260 | On the other hand, COVID-19 resulted in several hundred thousand deaths since December 2019 and remains without an efficient and safe treatment. […] The antimalarials chloroquine (CQ) and its analog, hydroxychloroquine (HCQ), have been tested for COVID-19 treatment, and several conflicting evidence has been obtained. | 2020-07-21 |
| 32686331 | Identification of prognostic factors is important for prevention and early treatment. | 2020-07-21 |
| 32686372 | Psychotropic medication was needed in five (6.9%), one of whom was admitted to the psychiatry department due to suicidality. | 2020-07-21 |
| 32686633 | Electrocardiograms were evaluated before, one day after and at the termination of the treatment. 21 patients aged 9 to 18 years were evaluated. […] We did not detect QT prolongation during or at the termination of the treatment. […] We did not detect QT prolongation during or at the termination of the treatment in our patients due to the fact that they were not severely affected by the disease. | 2020-07-21 |
| 32686774 | This paper reviews currently available data on the novel coronavirus and clinical features of COVID-19, followed by a detailed section on possible modifications of immunomodulatory therapy in multiple sclerosis patients with COVID-19, based on what we know so far. […] There are discussed: (i) The COVID-19 disease (Epidemiological background SARS-CoV-1 coronavirus; Autoimmune response to COVID-19; Asymptomatic course; SARS-CoV-2 test; COVID-19 symptoms), (ii) Treatment of COVID-19 (Experimental plasma treatment; Antiviral therapy; Antimalarial treatment scheme; Biological treatment; Corticosteroid treatment; Symptomatic treatment; Vaccine preparation) and (iii) Multiple sclerosis and SARS-CoV-2 infection (Epidemiological recommendation). | 2020-07-21 |
| 32686899 | Our aim was to investigate the impact of national lockdown and SARS-CoV-2 pandemic on percutaneous treatment of coronary artery disease in Poland. | 2020-07-21 |
| 32687061 | The questionnaire included sections on general information, the General Health Questionnaire-28 (GHQ-28), and the participant’s worries, disease knowledge, and need for hospital treatment. […] The hospital treatment need score after the internet consultation decreased from 3.3 (SD 1.2) to 1.6 (SD 0.8), and the difference was statistically significant (t3058=45.765, P<.001> | 2020-07-21 | </.001>
| 32687112 | Health systems have responded with the guidelines for prevention, management, and surveillance of the disease, while effort is being put in place to find a vaccine and a specific therapy for the cure of the disease. | 2020-07-21 |
| 32687151 | This article describes the processes and workflows for service delivery and early results of telehealth for IOP services in 2 adolescent treatment programs. | 2020-07-21 |
| 32687191 | To conduct a systematic literature review investigating treatment of neurosurgical patients via telemedicine, and to evaluate barriers and challenges. […] A systematic review was performed including all studies investigating success regarding treatment of neurosurgical patients via telemedicine. […] Telemedicine visits failed in 162 cases, 81.5% of which were due to technology failure, and 18.5% of which were due to patients requiring further face-to-face evaluation or treatment. | 2020-07-21 |
| 32687204 | The authors describe the treatment of pediatric patients with ophthalmological problems during the COVID-19 pandemic in an Italian tertiary eye center. | 2020-07-21 |
| 32687400 | This mechanistic link provides a scientific framework for translational studies of drugs developed for treatment of cardiometabolic disease as novel therapeutic interventions to mitigate inflammation and improve outcomes in patients with COVID-19. | 2020-07-21 |
| 32687485 | Here we describe a case of COVID-19 provoked pulmonary embolism in a young patient already receiving prophylactic treatment for VTE. | 2020-07-21 |
| 32687630 | To date, these medications are not approved for the treatment of viral infections, and there are no well-controlled, prospective, randomized clinical studies or evidence to support their use in patients with coronavirus disease 2019 (COVID-19). […] Nevertheless, chloroquine and hydroxychloroquine are being studied alone or in combination with other agents to assess their effectiveness in the treatment or prophylaxis for COVID-19. […] The effective use of any medication involves an understanding of its pharmacokinetics, safety, and mechanism of action. | 2020-07-21 |
| 32687645 | We performed a retrospective analysis of hospitalised patients who had a positive polymerase chain reaction test for SARS-CoV-2 and received HCQ plus Az or no targeted therapy. […] Data from a total of 134 patients were evaluated; 82 patients received HCQ/Az and 52 patients received no targeted therapy. […] The rates of intensive care transfer and mechanical ventilation were higher in the treatment group, but these differences were not significant. […] Mortality at day 28 was significantly higher in the treatment group (P = .03). […] The risk of QT prolongation was significantly higher in the treatment group. […] Treatment was stopped early in 6 (7.3%) patients due to adverse events. | 2020-07-21 |
| 32687677 | Some challenges and dilemmas currently faced during the pandemic include the management of cancer patients during the treatment and follow-up phases, the assessment of the safety of treatments currently used for the management of SARS-CoV-2 for use in cancer patients, the development of psychoeducation and emotional support for cancer patients and the safe conduct of clinical trials involving participation of cancer patients. | 2020-07-21 |
| 32687756 | Remdesivir for the treatment of Covid-19-preliminary report. | 2020-07-21 |
| 32687760 | Treatment of patients with nonsevere and severe coronavirus disease 2019: an evidence-based guideline. | 2020-07-21 |
| 32687917 | Extensive research work on recently discovered SARS-CoV-2 is in the pipeline to clarify pathogenic mechanisms, epidemiological features, and identify new drug targets that will lead to the development of successful strategies for prevention and treatment. | 2020-07-21 |
| 32687918 | Here, we describe the monocytes and macrophage responses during severe coronavirus infections, while highlighting potential therapeutic interventions to attenuate macrophage-related inflammatory reactions in possible approaches for COVID-19 treatment. | 2020-07-21 |
| 32687949 | The coronavirus infection (COVID-19) has turned into a global catastrophe and there is an intense search for effective drug therapy. […] Both drugs have been used in the treatment and prophylaxis of malaria. […] Long-term use of hydroxychloroquine is the cornerstone in the treatment of several auto-immune disorders. […] A few small uncontrolled trials and several anecdotal reports have shown conflicting results of such drug therapy in COVID-19. […] However, the results of preliminary large-scale randomized controlled trials have failed to show any survival benefit of such drug therapy in COVID-19. […] Despite the lack of such evidence, hydroxychloroquine has been used as a desperate attempt for prophylaxis and treatment of COVID-19. […] Indiscriminate unsupervised use can expose the public to serious adverse drug effects. | 2020-07-21 |
| 32687996 | For this reason, researchers and practitioners have promptly investigated the impact associated with the spread of SARS-CoV-2 on water treatment processes, focusing specifically on water disinfection. | 2020-07-21 |
| 32688005 | However, due to the occurrence of pre-symptomatic infections, the effect of the measures to shorten treatment time is markedly reduced and the importance of contact quarantine and social distancing increases. | 2020-07-21 |
| 32688099 | We suggest that these preliminary findings should be further investigated to help policymakers improve both their treatment of pandemic-related anxiety and their messages. | 2020-07-21 |
| 32688107 | 91.7 % of patients were prescribed antiviral therapy, followed by immune globulin (52.9 %) and systemic glucocorticoids (43.6 %). | 2020-07-21 |
| 32688137 | Now, numerous scientist are going on in the hope of obtaining medication and vaccination to prevent the spread of the disease and mortality of the disease. | 2020-07-21 |
| 32688139 | However, the recent discovery on benefits deriving from use of such anticoagulants for Covid-19 patients, has increased the success of patients’ treatment. […] Among lots of old and new drugs, PARP-inhibitors were not considered as possible option in the treatment of Covi-2 infection, being the latter able to induce the inflammatory and thrombotic cascades. | 2020-07-21 |
| 32688219 | The median age was 47 years old (y.o.), 31 patients were ≥ 60 y.o.; and 34% of patients reported comorbidities. 46% (51/110) of patients were treated by enzyme replacement therapy (ERT), 48 of them at hospitals; 45.1% (45/110) were on substrate reduction therapy (SRT) and 9% (10/110) receive no therapy. 25% (11/48) of ERT-hospital-based patients reported therapy interruptions, while SRT-patients did not report missing doses. […] Home-based therapy may need to be considered in order to minimize the impact of the COVID-19 pandemic. | 2020-07-21 |
| 32688395 | Robust analysis of outcomes for CLL patients, particularly examining effects of baseline characteristics and CLL-directed therapy, is critical to optimally manage CLL patients through this evolving pandemic. […] Thirty-nine percent were treatment naive (“watch and wait”), while 61% had received ≥1 CLL-directed therapy (median, 2; range, 1-8). […] Ninety patients (45%) were receiving active CLL therapy at COVID-19 diagnosis, most commonly Bruton tyrosine kinase inhibitors (BTKi’s; n = 68/90 [76%]). […] CLL-directed treatment with BTKi’s at COVID-19 diagnosis did not impact survival (case fatality rate, 34% vs 35%), though the BTKi was held during the COVID-19 course for most patients. […] These data suggest that the subgroup of CLL patients admitted with COVID-19, regardless of disease phase or treatment status, are at high risk of death. | 2020-07-21 |
| 32689586 | Despite treatment with prophylactic enoxaparin (initial D-Dimer 1.14 µg/ml FEU (normal < 0.05 µg/ml FEU), D-Dimer increased to above 20 µg/ml FEU and patient continued to spike high fevers. […] Treatment was changed to enoxaparin and no thrombotic events were encountered to date. | 2020-07-22 |
| 32689588 | Anticoagulation therapy may be considered in patients with COVID-19 though the risk of ICH should be taken into account when developing a treatment regimen. | 2020-07-22 |
| 32689813 | Therefore, it is important to strengthen the warning and monitoring of severe patients, and early identify the severe and critically severe types in time in the clinical treatment of COVID-19. […] Moreover, it is necessary to pay attention to the adverse reactions and damage to vital target organs caused by treatment drugs. […] This study reports the successful experience of diagnosis and treatment of an older patient with COVID-19 accompanied by progressive renal impairment, and pertinent literature was reviewed to help clinicians raise awareness of the disease. | 2020-07-22 |
| 32690074 | To assess the efficacy of local intranasal treatment with budesonide (nasal irrigation), in addition to olfactory rehabilitation, in the management of loss of smell in COVID-19 patients without signs of severity and with persistent hyposmia 30 days after the onset of symptoms. […] To search for an association between the presence of an obstruction on MRI and the severity of olfactory loss, at inclusion and after 30 days of treatment. […] Non-inclusion criteria - Known hypersensitivity to budesonide or any of the excipients; - Hemostasis disorder or epistaxis; - Oral-nasal and ophthalmic herpes virus infection; - Long-term corticosteroid treatment; - Treatment with potent CYP3A4 inhibitors (e.g., ketoconazole, itraconazole, voriconazole, posaconazole, clarithromycin, telithromycin, nefazodone and HIV protease inhibitors); - Severe forms of SARS-CoV-2 with respiratory or other signs; - Hyposmia persisting for more than 90 days after the onset of symptoms - Other causes of hyposmia found on interrogation or MRI; - Patient benefiting from a legal protection measure; - Pregnant or breastfeeding women. […] Percentage of patients with an improvement of more than 2 points on the ODORATEST score after 30 days of treatment. | 2020-07-22 |
| 32690096 | The fight against COVID-19 should have two aspects: one is the treatment of infected patients, and the other is the mobilization of the society to avoid the spread of the virus. […] The treatment of patients includes supportive treatment, antiviral treatment, and oxygen therapy. […] Plasma therapy and traditional Chinese medicine have also achieved good outcomes. […] This review is intended to summarize the research on this new coronavirus, to analyze the similarities and differences between COVID-19 and previous outbreaks of severe acute respiratory syndrome (SARS) and Middle East respiratory syndrome (MERS) and to provide guidance regarding new methods of prevention, diagnosis and clinical treatment based on autodock simulations. | 2020-07-22 |
| 32690179 | In the absence of treatment for this virus, there is an urgent need to find alternative methods that can contribute to control of disease. | 2020-07-22 |
| 32690231 | Therefore, in addition to etiological and supportive treatment, immunomodulatory therapy is also appropriate to severe COVID-19. […] Although there is still a lack of consensus on immunotherapy for sepsis so far, relatively rich experiences have been accumulated in the past decades, which will help us in the treatment of severe COVID-19. | 2020-07-22 |
| 32690444 | Epidemiological, clinical, laboratory, radiological, and treatment data from 17 patients diagnosed with COVID-19 between January 20 and February 20, 2020 were collected and analyzed retrospectively. […] Treatment outcomes among subgroups of patients with non-severe and severe symptoms of COVID-19 were compared. […] All patients received antiviral therapy, while some patients also received intravenous antibiotics therapy (76.5%), Chinese medicinal preparation therapy (Lianhuaqingwen capsule, 64.7%), corticosteroids (35.3%) or immunoglobin (29.4%). | 2020-07-22 |
| 32690572 | The patient was admitted for 1 day; immunosuppressive therapy with tacrolimus and low-dose prednisolone was continued; and the patient recovered successfully without the use of antiviral agents or oxygen therapy. […] Withdrawal of immunosuppressive therapy could be associated with poorer outcomes and should not be implemented thoughtlessly. | 2020-07-22 |
| 32690631 | Adaptations in diabetes care in the hospital (ie, changes in treatment protocols according to clinical status, diabetes technology implementation) and outpatient setting (telemedicine, mail delivery, patient education, risk stratification, monitoring) have been improvised to address this challenge. | 2020-07-22 |
| 32690870 | Benefit of care from treatment must be carefully weighed against the potential of infection and morbidity from COVID-19. […] Treatment may be safely deferred in low and intermediate risk patients. […] In patients with cN1 disease, treatment within 6 weeks is advocated. | 2020-07-22 |
| 32690998 | We present a case of a young veteran who presented with e-cigarette vaping associated lung injury (EVALI) to a primary care clinic and who required subsequent inpatient admission and home oxygen therapy after discharge. | 2020-07-22 |
| 32690999 | Rapid review methods will be applied to a systematic review of zinc for the prevention or treatment of SARS-CoV-2 and viral respiratory tract infections in humans. | 2020-07-22 |
| 32691000 | A total of 14 sources were searched for potential guidelines that provide herbal medicine treatment for the medical observation period of COVID-19. | 2020-07-22 |
| 32691002 | We analyzed the symptoms of SARS-CoV-2, a classification of the Chinese medicine dialectic and treatment regimen, and promptly enacted the recommendation of Korean medicine preparations in herbal medicine covered under domestic medical insurance benefits depending on the circumstances in our country. […] The clinical practice guideline (CPG) for the treatment of SARS-CoV-2 was developed based on consensus from a group of experts. […] The CPG was developed to guide the use of Korean herbal medicine in the treatment of SARS-CoV-2, and it is expected that this will be the basis for providing proper treatment of similar infectious diseases in the future. | 2020-07-22 |
| 32691003 | This findings may help the clinician determine the correct treatment and security measure that need to be taken aaccording to the phase of the disease. | 2020-07-22 |
| 32691006 | This review describes the etiology and signs and symptoms as well as the current allopathic therapy for COVID-19. […] Additionally, findings of previous studies on the immunomodulatory effects and antiviral activities of particular foods and herbs on influenza virus and coronaviruses have been collated, with the aim of promoting the use of dietary therapy and herbal medicine as COVID-19 preventive therapies, while specific drugs and vaccines are yet to be discovered or are still under development. […] Foods and herbs could be used as dietary or complementary therapy to prevent infection and strengthen immunity, as antiviral agents for masks, as disinfectants to curb aerosol transmission, or as sanitizing agents to disinfect surfaces. | 2020-07-22 |
| 32691007 | Immunomodulatory therapy has the potential to inhibit cytokines and quell the immune dysregulation. […] Controversial data found improved oxygenation after treatment with tocilizumab, an interleukin-6 inhibitor, sparking a wave of interest and resultant clinical trials evaluating immunomodulatory therapies. | 2020-07-22 |
| 32691024 | In this review we summarize the most up to date literature around the association between COVID-19 and myocarditis and provide clinicians a practical framework about the clinical manifestations, diagnostic tools, and treatment options currently available. […] Emergent treatment options for COVID-19 are in clinical trials and might be of benefit to COVID-19 patients with myocarditis in addition to current guideline-based recommendations. | 2020-07-22 |
| 32691056 | The goals of the rehabilitation-based prone team were to provide support to nursing and respiratory therapy; create a consistent, efficient process; and ensure patient and staff safety. | 2020-07-22 |
| 32691235 | Other outcomes were the IRR for stroke subtypes, change in use of reperfusion therapy, treatment times, and in-hospital complications. […] There was no change in the proportion of stroke patients treated with intravenous thrombolysis (28% vs. 30%, p = 0.58) or endovascular thrombectomy (11% vs 12%, p = 0.82) or associated treatment times. | 2020-07-22 |
| 32691334 | With evidence collected from clinical studies on COVID-19 and basic research on a rare genetic disease (i.e., Hartnup disorder), we put forward a novel hypothesis to elaborate an effective nutritional therapy. | 2020-07-22 |
| 32691448 | In a region with milder impact of COVID-19, treatment of cancer patients need not be deferred. | 2020-07-22 |
| 32691604 | These guidelines helped with streamlining care in times of crisis, providing care to those in need, supporting frontline staff with primary-level palliative care, and minimizing the GAP team’s risk of infection and burnout during the rapidly changing pandemic response. | 2020-07-22 |
| 32691645 | Management of severe dermatologic disorders in patients who require systemic immunosuppressive treatment is a major concern in COVID-19 pandemic era. […] During this interval, he not only discontinued his medication, but also became SARS-CoV-2 positive. | 2020-07-22 |
| 32691680 | Treatment efforts have been severely impeded due to the lack of specific effective antiviral drugs for the treatment of COVID-associated pathologies. […] Present research findings bestow ample scopes to further exploit the potential of deoxycylindrospermopsin as a successful inhibitor of SARS-CoV-2 in vitro and in vivo and pave the foundation for the development of novel effective therapeutics against COVID-19. | 2020-07-22 |
| 32691695 | Further investigations are required to better understand the molecular sequelae in order to guide potential therapy in the management of severe coronavirus disease 2019 (COVID-19) patients. | 2020-07-22 |
| 32691730 | We describe the clinical characteristics, radiological findings, and treatment of the hemodialysis patient, including the patient’s initial pneumonia at presentation with progression to acute respiratory distress syndrome (ARDS). | 2020-07-22 |
| 32692176 | Neutrophils may contribute to the diffuse alveolar inflammation seen in acute respiratory distress syndrome (ARDS) which is currently a growing challenge for intensive care units due to the outbreak of the COVID-19 pandemic. | 2020-07-22 |
| 32692185 | If sufficient efficacy of some of these FDA-approved drugs in inhibiting viral replication in cell culture is established, they may be explored as potential COVID-19 therapeutics. | 2020-07-22 |
| 32692208 | The information on the epidemiological, clinical characteristics, laboratory tests, radiological features on admission, treatment and outcome were obtained with the final follow-up of March 13, 2020. […] All 86 patients received antiviral and traditional Chinese medicine therapy, 53 (61.6%) received antibacterial therapy, and 3 (3.5%) patients received invasive ventilator mechanical ventilation. […] The proportion of patients received antibiotic treatment in long-hospital stay group was significantly higher than that in the short-hospital stay group (P=0.045). | 2020-07-22 |
| 32692228 | However, a technical standard for oxygen therapy nursing, as well as how this would improve clinical outcomes and symptoms, is yet to be explored. […] Fifteen patients who did not receive oxygen therapy and 13 patients who were transferred from other hospitals were excluded. […] The rest of the 30 patients that received standardized oxygen therapy in our unit were included in the study. […] The fingertip oxygen saturation was 94.80%±3.49% at ICU admission and 97.8%±1.27% when transferred out of ICU after standardized oxygen therapy (P<0.005). […] The standardized oxygen therapy nursing strategy for patients with COVID-19 emphasizes the nursing measurement, which focuses on the patient’s oxygenation. […] It is led by nurses and starts oxygen therapy at an earlier stage. | 2020-07-22 |
| 32692230 | We aimed to clarify the epidemiology, laboratory examinations, imaging findings, and treatment of critically ill patients with COVID-19 in Hebei province, China. […] In this retrospective study, the demographic, laboratory and imaging, and treatment data of patients with severe COVID-19 treated in 13 designated hospitals in Hebei were collected and analyzed. […] The critically severe patients received more fluid and more diuretic treatment; 14 (70.0%) required invasive mechanical ventilation, and 13 (65.0%) developed extrapulmonary complications. | 2020-07-22 |
| 32692238 | This case highlighted the importance of close coordination between Chinese medicine and western medicine in the diagnosis and treatment, as well as the need for rapid dissemination of clinical information related to patient care with this emerging infection. | 2020-07-22 |
| 32692241 | According to the fifth and sixth editions of the new coronavirus pneumonia diagnosis and treatment plan issued by the National Health Commission of the People’s Republic of China and National Administration of Traditional Chinese Medicine, we carried out the case analysis and infectious disease investigation and research on the confirmed and suspected cases of new coronavirus pneumonia admitted to the second-floor ward of the hospital from January 28th, 2020, to February 26th, 2020. […] The combination of traditional Chinese and western medicine in the treatment of new coronavirus pneumonia might help patients. | 2020-07-22 |
| 32692266 | Several pharmaceutical companies in collaboration with various academic institutions and governmental organizations have started investigating new therapeutics and repurposing approved drugs so as to find fast and affordable treatments against this disease. […] This article is going to be of immense help to the scientific community and researchers as it brings forth all the necessary clinical information of the most-talked-about therapeutics against SARS-CoV-2. | 2020-07-22 |
| 32692306 | Computer-aided drug screening by molecular docking, molecular dynamics (MD) and structural-activity relationship (SAR) can offer an efficient approach to identify promising drug repurposing candidates for COVID-19 treatment. | 2020-07-22 |
| 32692406 | However, it remains unclear whether people living with human immunodefeciency virus (PLWH) are at an increased risk of COVID-19 and severe disease manifestation, with controversial suggestion that HIV-infected individuals could be protected from severe COVID-19 by means of antiretroviral therapy or HIV-related immunosuppression. | 2020-07-22 |
| 32692462 | It is not known whether the adverse events (AEs) associated with the administration of lopinavir and ritonavir (LPV/r) in the treatment of COVID-19 are concentration-dependent. | 2020-07-22 |
| 32692584 | Conclusions Speech-language pathologists play a critical role in the assessment, management, and treatment of patients with COVID-19. | 2020-07-22 |
| 32692647 | We have identified a novel antiviral formulation that is of great interest for the prevention and/or treatment of a broad range of enveloped viruses, particularly those of the skin and mucosal surfaces. | 2020-07-22 |
| 32692648 | To estimate the impact of the timing and intensity of such measures, we built a mathematical model of COVID-19 transmission that incorporates age-stratified risks and contact patterns and projects numbers of hospitalizations, patients in intensive care units, ventilator needs, and deaths within US cities. […] A 2-week delay in implementation was projected to accelerate the timing of peak healthcare needs by 4 weeks and cause a bed shortage in intensive care units. | 2020-07-22 |
| 32692700 | Despite continued uncertainty and a lack of clarity about the COVID-19, researchers have made tremendous strides in the development of prevention and treatment strategies. | 2020-07-22 |
| 32692733 | Concurrent treatment with immunosuppressants, including corticosteroids, increases the risk of developing a severe form of coronavirus disease 2019 (COVID-19) due to infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). […] The World Health Organization (WHO) advises against the use of corticosteroids in patients with SARS-CoV-2 due to their poor outcomes in patients with SARS-CoV and Middle East respiratory syndrome (MERS-CoV), unless these patients require steroid treatment for a coexisting disease. […] Thorough etiological workup revealed an elevated IgG4 level of 361 mg/dL and significant clinical response to corticosteroid treatment, leading to a diagnosis of AIP. […] After finishing steroid treatment at home, the patient was readmitted with another episode of AIP complicated by development of acute necrotic collection and COVID-19 while taking a second course of high dose prednisone. […] These findings support the use of corticosteroids when necessary for treatment of coexisting conditions in COVID-19 patients. | 2020-07-22 |
| 32692769 | Lung ultrasound is well suited to this interstitial, subpleural involvement, and it is now broadly used in intensive care units (ICUs). | 2020-07-22 |
| 32692801 | Despite many groups have engaged in studying the newly emerged virus and searching for the treatment of COVID-19, the understanding of the COVID-19 target-ligand interactions represents a key challenge. | 2020-07-22 |
| 32692858 | In this perspective, the potential application of stem cells for the treatment of COVID-19 related pneumonia and their potential mechanism of action have been overviewed. | 2020-07-22 |
| 32692862 | Active cancer required cancer-directed therapy within previous 6 months. | 2020-07-22 |
| 32692867 | Teletherapy became the primary means of service delivery for many who had never or only sparingly used it. […] The Family Institute at Northwestern University, in response to encouraging findings with respect to the effectiveness of teletherapy and recognizing advantages with respect to access to care, launched our teletherapy services in 2018. […] As a relationship-based organization, we were keen to exploit the opportunity that teletherapy provides to integrate additional members of the client system into the treatment. […] Our learning was greatly accelerated by our transition to a 100% teletherapy practice in the wake of the pandemic. […] Teletherapy is a different context. […] Intentionally managing the context’s constraints and exploiting its strengths is key to providing high-quality couple and family therapy. […] This step is often overlooked or resisted when teletherapy is an occasional add-on to a face-to-face practice. | 2020-07-22 |
| 32692877 | We thank Tang et al. for their perspective on the possible limitation of D-dimer levels guiding anticoagulant treatment in patients with COVID-19 [1]. […] It has never been validated to guide clinical treatment or anticoagulation. | 2020-07-22 |
| 32692934 | High risk prostate cancer may need preferential treatment and consideration of neoadjuvant hormonal therapy. […] Likewise, adrenal cancer is aggressive and needs early surgical treatment. […] This review should further assist urologists in recognizing patients with potentially aggressive tumor biology that warrants early treatment. | 2020-07-22 |
| 32693224 | Treatment, scope, duration, and economic burden forced a major restructuring of our medical practice. | 2020-07-22 |
| 32693241 | Given the potential role of these components in organ damage and pathological manifestations of patients infected with COVID-19, their blockage might be a hopeful and promising treatment strategy. […] Notably, more study on long non-coding RNAs involved in inflammatory responses could elevate the efficacy of anti-inflammatory therapy. | 2020-07-22 |
| 32693284 | In this study, raw and treated samples from three wastewater treatment plants, and three river samples within the Milano Metropolitan Area, Italy, were surveyed for SARS-CoV-2 RNA detection by means of real time RT-PCR and infectivity test on culture cells. | 2020-07-22 |
| 32693298 | Unfortunately, no registered specific therapies (including antiviral therapies, immune-modulating agents and vaccines) are currently available to treat coronavirus infections, highlighting an urgent need for therapeutics targeting SARS-CoV-2. | 2020-07-22 |
| 32693436 | Using a target-cell limited model structure that has been used to characterize viral load dynamics from COVID-19 patients, we performed simulations to inform on the combinations of therapeutics targeting specific rate constants. | 2020-07-22 |
| 32693646 | Baricitinib is approved for the treatment of rheumatoid arthritis (RA). | 2020-07-23 |
| 32693650 | This retrospective study included patients with severe COVID-19 requiring oxygen therapy who received tocilizumab in seven centers across Poland. […] We assessed on-treatment changes in clinical status and inflammatory markers. […] Sixteen patients (57%) no longer needed oxygen therapy within a week (p < 0.001). […] Lung changes improved in 21 (84%) patients within two weeks of treatment; 19 had minimal or no changes upon final examination. | 2020-07-23 |
| 32693652 | Given the current lack of an effective vaccine, several drugs have been repurposed for treatment and prophylaxis of COVID-19 in an attempt to find an effective cure. […] To date, clinical evidence suggests lack of benefit from HCQ use for the treatment of hospitalized patients with COVID-19. | 2020-07-23 |
| 32693665 | In absence of a vaccine or a widely available effective therapy, quarantine and other preventive measures are essential in curtailing the risk of pandemic spread. | 2020-07-23 |
| 32693756 | Therefore, there is an urgent need to find new therapeutics that can be progressed to clinical development as soon as possible. | 2020-07-23 |
| 32693757 | The present write-up also discusses the recent progress of patent applications in a period of the year 2010 to 2020 (present) along with the recent developments in India for the treatment options for CoV and 2019-nCoV. […] Present analysis showed that key areas of the inventions have been focused on vaccines and diagnostic kits apart from the composition for treatment of CoV. […] We also observed that no specific vaccine treatments is available for treatment of 2019-nCov, however, developing novel chemical or biological drugs and kits for early diagnosis, prevention and disease management is the primarily governing topic among the patented inventions. […] Further, the findings and outcome of the present study offer insights for the proposed research and innovation opportunities and provide actionable information in order to facilitate policymakers, academia, research driven institutes and also investors to make better decisions regarding programmed steps for research and development for the diagnosis, treatment and taking preventive measures for CoV and 2019-nCoV. | 2020-07-23 |
| 32694043 | However, so far no approved vaccine or drug therapy is available for treatment of virus infection. […] One hundred eighty-nine COVID-19 positive patients including 115 patients in plasma therapy group and 74 patients in control group, registered in the hospitals with confirmed COVID-19 infection, entered this multi-center clinical study. […] This clinical study provides strong evidence to support the efficacy of convalescent plasma therapy in COVID-19 patients and recommends this treatment for management of these patients. […] Clinical efficacy, immediate availability and potential cost effectiveness could be considered as main advantages of convalescent plasma therapy. | 2020-07-23 |
| 32694078 | However, there is very scarce information on the management of thrombotic risk, coagulation disorders, and anticoagulant therapy. […] This article by the Working Group on Cardiovascular Thrombosis of the Spanish Society of Cardiology aims to summarize the available information and to provide a practical approach to the management of antithrombotic therapy. | 2020-07-23 |
| 32694083 | Finally, we identified 25 cases (75.8%) were isolated for hospitalized treatment after positive virus detection. | 2020-07-23 |
| 32694130 | Here, we tested wastewater collected at a major urban treatment facility in Massachusetts and detected SARS-CoV-2 RNA from the N gene at significant titers (57 to 303 copies per ml of sewage) in the period from 18 to 25 March 2020 using RT-qPCR. | 2020-07-23 |
| 32694201 | These findings advance our understanding of SARS-CoV-2 entry and may guide the development of vaccines and therapeutics. | 2020-07-23 |
| 32694244 | In the absence of an effective antiviral treatment, a reasonable causal approach could be constituted by the neutralization of these substances. […] Blood levels of IL-6 and C-reactive protein (CRP) were measured before the initiation of the treatment and in the following 3 days. […] At the end of the treatment, the values of IL-6 and CRP decreased from 1,040 to 415 pg/mL and from 229 to 59 mg/L, respectively. […] The combination of tocilizumab and HA could be valuable in the treatment of SARS-COV-2-19-associated pneumonia and ARDS that are caused by the release of inflammatory mediators. | 2020-07-23 |
| 32694268 | Using natural language processing (NLP) and data integration methods, topic modeling on more than 200 ophthalmology-related articles on COVID-19 can summarize ocular manifestations, viral transmission, treatment strategies, and patient care and practice management. | 2020-07-23 |
| 32694291 | The clinical pharmacist addressed COVID-19 and inflammatory bowel disease treatment concerns with 140 patients, conducted 34 medication education and monitoring visits, reviewed 141 patients’ charts and helped rescheduled 18 patients who missed their biologic infusion, transitioned 12 patients to home infusions, and assisted 5 patients with medication access. | 2020-07-23 |
| 32694358 | Only 6% of respondents prescribed HCQ/CQ for COVID-19 prophylaxis, and only 12% for outpatient treatment of COVID-19. […] Further, compared to the United States and those with 1 to 5 years of experience, rheumatologists in Europe (aRR, 2.9; 95% CI, 1.6-5.3; p < 0.001) and those with 10+ years of experience (11-20 years: aRR, 2.5; 95% CI, 1.2-5.3; p = 0.015; 21+ years: aRR = 3.3; 95% CI, 1.4-7.4; p = 0.004) had a higher likelihood of prescribing HCQ/CQ for outpatient treatment. […] The results suggest that only a small percentage of rheumatologists are prescribing HCQ/CQ for prophylaxis or outpatient treatment of COVID-19. […] Medication shortages experienced by large numbers of autoimmune disease patients are concerning and should play a role in decisions, especially given poor efficacy data for HCQ/CQ in COVID-19. | 2020-07-23 |
| 32694915 | Hydroxychloroquine/chloroquine, lopinavir/ritonavir, ribavirin, interferons, umifenovir, remdesivir, and interleukin antagonists, such as tocilizumab, have been recommended as potential treatment options in COVID-19. […] At the same time, with regard to receiving polypharmacy and immunosuppressants, treatment options should be chosen with more attention in this population. […] Considering drug-drug interactions and adverse effects of medications used for the treatment of COVID-19, such as QT prolongation, the dose reduction of some immunosuppressants or avoidance is recommended in transplant recipients with COVID-19. […] Thus, this narrative review describes clinically important considerations about the treatment of COVID-19 and immunosuppressive regimens regarding modifications, side effects, and interactions in adult kidney or liver allograft recipients. | 2020-07-23 |
| 32695122 | Understanding these pathways may help not only in unraveling disease pathogenesis, but also in suggesting targets for therapy and prophylaxis. […] Importantly such insight should instruct efforts to identify those at increased risk in order to institute preventative measures, such as prophylactic medication and/or vaccination, when such opportunities arise in the later phases of the current pandemic or during future similar pandemics. | 2020-07-23 |
| 32695170 | This review presents evidence-based patient management practice and protocols from the available literature to help formulate a contingency plan with recommendations, for the dental practices prior to patients’ visit, during in-office dental treatment, and post-treatment, during the pandemic and after. | 2020-07-23 |
| 32695203 | The management of locally advanced cervical cancer presents specific challenges in this context, especially brachytherapy and completion of radiotherapy treatment, without compromising the overall treatment time and anticipated outcomes. […] The review attempts to provide possible explanations and pathways based on COVID-19 testing, brachytherapy processes including application, imaging, and fractionation, keeping in mind the overall treatment time. | 2020-07-23 |
| 32695321 | The home treatment setting of peritoneal dialysis (PD) has advantages in terms of implementing self-care when routine hospital visits and social activities are restricted, thus greatly reducing exposure of PD patients to the virus. […] The diagnosis and treatment of PD patients with COVID-19 are discussed. | 2020-07-23 |
| 32695322 | Four of seven (57%) received oxygen therapy, one (14%) received noninvasive and invasive mechanical ventilation, five (71%) received antiviral and antibacterial drugs, three (43%) recieved glucocorticoid therapy and one (14%) received continuous renal replacement therapy. | 2020-07-23 |
| 32695326 | Single-centre cohort performed from 3 March 2020 to 14 April 2020 in four intensive care units in Bordeaux University Hospital, France. […] AKI developed in a total of 57/71 (80%) patients, with 35% Stage 1, 35% Stage 2 and 30% Stage 3 AKI; 10/57 (18%) required renal replacement therapy (RRT). | 2020-07-23 |
| 32695328 | So far, little is known about the course of the disease and its symptoms, complications and treatment. | 2020-07-23 |
| 32695687 | Self medications and poor compliance of dermatology patients in addition to lack of proper treatment protocols and monitoring are a serious concern in the present scenario. | 2020-07-23 |
| 32695791 | Background: The unprecedented impact of the COVID-19 pandemic on modern society has ignited a “gold rush” for effective treatment and diagnostic strategies, with a significant diversion of economic, scientific, and human resources toward dedicated clinical research. | 2020-07-23 |
| 32695804 | This warrants urgent consideration of divergent modalities such as the cellular therapy. […] Cellular therapy (CT) is a new medical paradigm wherein cellular material is administered to patients for therapeutic purposes. | 2020-07-23 |
| 32696004 | Currently, the optimal treatment for severe coronavirus disease 2019 is uncertain. […] Supportive treatment and immunomodulators have a critical place in the treatment of severe patients until effective antivirals are developed. […] Interleukin-6 antagonists, one of the immunomodulating agents, appears to be effective in the treatment of cytokine storm, but some patients continue to have severe lymphopenia and immunosuppression. […] We believe it can be useful as immunomodulator therapy in critical coronavirus disease 2019 patients because of the benefits of immune checkpoint inhibitors in cancer and sepsis patients. | 2020-07-23 |
| 32696013 | Antibody assays that quantitatively measure neutralizing antibodies are needed to test efficacy of convalescent plasma therapy but are more specialized. | 2020-07-23 |
| 32696014 | Renal replacement therapy in coronavirus disease 2019 patients is complicated by increased activation of the coagulation system. […] Nine renal replacement therapy sessions in patients anticoagulated with high doses of unfractionated heparin had to be discontinuated prematurely because of clotting of tubes or membrane and poor quality of hemodialysis. | 2020-07-23 |
| 32696057 | In addition to any direct effects of COVID-19 on the health of PLWH, we need to understand how physical distancing restrictions impact secondary health outcomes, and the need for, accessibility of, and impact of alternative modalities of providing ongoing medical, mental health, and substance use treatment that comply with physical distancing restrictions (e.g., telemedicine). | 2020-07-23 |
| 32696088 | Briefly, in phase 1, EEG was recommended only for those acute/subacute neurological symptoms where EEG is necessary for diagnosis, prognosis, or therapy. […] During the different phases of COVID-19 pandemic, the EEG should be reserved for patients really benefiting from its execution in terms of diagnosis, treatment, prognosis, and avoidance of emergency room access. | 2020-07-23 |
| 32696396 | All the patients accepted standard supportive treatment for COVID-19. | 2020-07-23 |
| 32696426 | Cells derived from the placenta and/or fetal membranes, in particular amniotic epithelial cells (AEC) and decidual stromal cells (DSC), have established, well-characterized, potent anti-inflammatory and immune-modulatory properties that make them attractive candidates for a cell-based therapy of COVID19 pneumonia. […] In view of the existing clinical evidence for the innocuousness and efficiency of systemic administration of DSCs or AECs in similar conditions, we advocate for the initiation of clinical trials using this strategy in the treatment of severe COVID-19 disease. | 2020-07-23 |
| 32696429 | Azithromycin, in association with hydroxychloroquine or chloroquine, has been proposed as one such medication. […] Therefore, this antibacterial should be considered only as empirical treatment of community-acquired pneumonia (CAP), although not all current treatment guidelines are in agreement. […] The World Health Organization has not made recommendations suggesting the use of azithromycin with hydroxychloroquine or chloroquine as treatment for COVID-19, but some national organisations have taken a different position, recommending this as first-line treatment. […] Several scientific societies, including the American College of Cardiology, have cautioned about the risks of this treatment in view of the lack of evidence concerning its benefits. | 2020-07-23 |
| 32696443 | Therefore, several empirical oxygenation support initiatives have been initiated with intermittent hyperbaric oxygen (HBO) therapy to overcome the unrelenting and progressive hypoxemia during maximum ventilator support in intubated patients, despite high FiO2. […] This summary illustrates the biological mechanisms of action of increased O2 pressure, hoping to clarify more appropriate protocols and more useful application of HBO in COVID-19 treatment. | 2020-07-23 |
| 32696720 | Given that these molecules are effective antivirals with excellent safety track records in humans against various ailment, we recommend their potential repurposing for the treatment of SARS-CoV-2 patients after successful clinical studies. | 2020-07-23 |
| 32696759 | Although quarantine can effectively prevent and control viral infections, there is no effective drug treatment available. […] To avoid further greater losses, it is tremendously necessary to investigate an effective treatment plan. | 2020-07-23 |
| 32696810 | A significant correlation between the number of cases and sewage treatment index/population density was observed. […] In addition, COVID-19 incidence and mortality rates were significantly associated with the total water service index and lethality rate was significantly associated with the sewage treatment index. | 2020-07-23 |
| 32696811 | Despite treatment with recombinant human interferon, convalescent plasma from COVID-19 patients, arbidol, etc., nucleic acid results were still positive for SARS-CoV-2. […] After treatment with ritonavir-boosted danoprevir (DNVr, 100/100 mg, once daily), all four patients showed two to three consecutive negative SARS-CoV-2 RNA and were thus discharged from hospital. | 2020-07-23 |
| 32696862 | There is currently no authorized medication for the treatment of COVID-19. […] Remdesivir is currently the most promising molecule in the treatment of COVID-19, taking into account its broad antiviral spectrum (considering the genetic sequences of the virus, it is expected to maintain activity against SARS-CoV-2). | 2020-07-23 |
| 32696883 | Therefore, anticoagulation, considering its mortality benefits in cases of non-Covid sepsis, may also have an important role in the treatment of Covid-19. […] RESULTS Anticoagulation therapy can be started following the DIC diagnosis in Covid-19 patients despite the bleeding risks. […] CONCLUSION Covid-19 is a systemic, hypercoagulable disease requiring more studies concerning treatment. […] Aanticoagulation is still an issue to be studied, but D-dimer rise and disease severity are the indicative factors to start treatment as soon as possible. | 2020-07-23 |
| 32696884 | OBJECTIVE Various integrated Chinese and Western medicines might be beneficial for the treatment of Coronavirus disease 2019 (COVID-19). […] This study aims to evaluate the efficacy of lung computed tomography (CT) of four integrated Chinese and Western medicines in the treatment of COVID-19 using network meta-analysis (NMA). […] METHODS Multiple databases were consulted to find randomized controlled trials of four different types of integrated Chinese and Western medicines for the treatment of COVID-19. […] CONCLUSIONS A combination of symptomatic and supportive care with Lianhua Qingke is the best option among the four integrated Chinese and Western medicines considered for the treatment of COVID-19. | 2020-07-23 |
| 32697120 | Purchasing consecutively at least three ADHD-medication-prescriptions during past year was considered drug-treatment. […] Conclusion: Untreated ADHD seems to constitute a risk factor for Covid-19 infection while drug-treatment ameliorates this effect. | 2020-07-23 |
| 32697171 | Medications for opioid use disorder (MOUD), such as methadone and buprenorphine, are effective strategies for treatment of opioid use disorder (OUD) and reducing overdose risk. […] MOUD treatment rates continue to be low across the US, and currently, some evidence suggests access to evidence-based treatment is becoming increasingly difficult for those with OUD as a result of the 2019 novel corona virus (COVID-19). […] Canadian, Australian, and European pharmacists have made important contributions to the treatment and care of those with OUD over the past decades. […] Unfortunately, US pharmacists are not permitted to prescribe MOUD and are only currently allowed to dispense methadone for the treatment of pain, not OUD. […] Advancing community pharmacy-based MOUD for leading clinical management of OUD and dispensation of treatment medications will afford the US a critical innovation for addressing the opioid epidemic, fallout from COVID-19, and getting individuals the care they need. | 2020-07-23 |
| 32697172 | Hence, we discuss: (1) why persons with substance use disorders are at increased risk for infection with COVID-19 and a severe illness course; (2) anticipated adverse consequences of COVID-19 in persons with substance use disorders; (3) challenges to health care delivery and substance use treatment programs during and after the COVID-19 pandemic; and (4) the potential impact on clinical research in substance use disorders. | 2020-07-23 |
| 32697367 | If this hypothesis is proven, a different treatment approach might change the outcome in severe cases. | 2020-07-23 |
| 32697423 | The COVID-19 pandemic also jeopardizes essential for PWID services, such as needle exchange or substitution therapy programmes, which can be affected both in a short- and a long-term perspective. | 2020-07-23 |
| 32697705 | During the COVID-19 pandemic, electroconvulsive therapy units have had to confront challenges such as the infectious hazard due to aerosol-generating ventilation, or the lack of staff and material resources. | 2020-07-23 |
| 32697769 | Hydroxychloroquine therapy started initially, was discontinued after 3 doses once the G6PD deficiency was diagnosed. […] CONCLUSIONS Hydroxychloroquine therapy can induce hemolytic crises in patients with underlying G6PD deficiency or hemoglobinopathies and should be avoided or closely monitored. | 2020-07-23 |
| 32697835 | Hormone supplement might be a potential therapy for COVID-19 patients. | 2020-07-23 |
| 32698147 | This single-center study was retrospective and consisted in evaluating thyroid function tests and serum interleukin-6 (IL-6) values in 287 consecutive patients (193 males, median age: 66 years, range: 27-92) hospitalized for COVID-19 in non-intensive care units. | 2020-07-23 |
| 32698190 | To develop antiviral interventions quickly, drugs used for the treatment of unrelated diseases are currently being repurposed to treat COVID-19. […] Chloroquine is an anti-malaria drug that is used for the treatment of COVID-19 as it inhibits the spread of SARS-CoV-2 in the African green monkey kidney-derived cell line Vero1-3. | 2020-07-23 |
| 32698191 | Coronavirus disease 2019 (COVID-19) has rapidly become a global pandemic and no antiviral drug or vaccine is yet available for the treatment of this disease1-3. […] In macaques, we tested different treatment strategies in comparison to a placebo treatment, before and after peak viral load, alone or in combination with azithromycin (AZTH). […] When the drug was used as a pre-exposure prophylaxis treatment, HCQ did not confer protection against infection with SARS-CoV-2. […] Our findings do not support the use of HCQ, either alone or in combination with AZTH, as an antiviral drug for the treatment of COVID-19 in humans. | 2020-07-23 |
| 32698230 | Yet homeopathy may have a relevant role to play, inasmuch as the vast majority of patients only exhibit the mild form of disease and are indicated to self-care at home, without standard monitoring, follow-up, or treatment. | 2020-07-23 |
| 32698378 | Pain in ICU patients can be associated with viral disease itself (myalgia, arthralgia, peripheral neuropathies), may be caused by continuous pain and discomfort associated with ICU treatment, intermittent procedural pain and chronic pain present before admission to the ICU. […] Undertreatment of pain, especially when sedation and neuromuscular blocking agents are used, prone positioning during mechanical ventilation or extracorporeal membrane oxygenation (ECMO) may trigger delirium and cause peripheral neuropathies. […] A structured prospective evaluation should be undertaken to analyze the probability, severity, sources and adequate treatment of pain in patients with COVID-19 infection. | 2020-07-24 |
| 32698440 | Treatment with tiotropium has been shown to improve pulmonary function by alleviating airway inflammation. | 2020-07-24 |
| 32698479 | More than 10 million affected cases and more than half a million deaths have been reported so far, while no vaccine is yet available as a treatment. | 2020-07-24 |
| 32698626 | Proposed molecules have been designed based on the structure of triterpene oleanolic acid and complemented by structures characteristic of selected anti-COVID therapy assisted drugs. | 2020-07-24 |
| 32698732 | Considering the possibility of neurological involvement in patients with SARS-CoV-2 infection can result in earlier diagnosis and treatment; otherwise permanent, irreversible sequelae and even death may follow. | 2020-07-24 |
| 32698822 | The current study suggested that SpO2/FiO2 could serve as a non-invasive prognostic marker to facilitate early adjustment for treatment, thus improving overall survival. | 2020-07-24 |
| 32698853 | UFH is widely available and inexpensive, which may make this treatment also accessible for low- and middle-income countries.These potentially important therapeutic properties of nebulised UFH underline the need for expedited large-scale clinical trials to test its potential to reduce mortality in COVID-19 patients. | 2020-07-24 |
| 32698898 | Current clinical management strategies are respiratory support and restricted fluid input, and there is no suggested pharmacological treatment. […] In this review, we will focus on clinical progress in the use of MSCs as a cell therapy for ARDS, which may have clinical implications during the coronavirus disease 2019 (COVID-19) pandemic. | 2020-07-24 |
| 32698917 | During the pandemic, the proportion of COVID-19 positive patients was low (3%), the time from symptom onset to hospital presentation was significantly longer, and a smaller proportion of patients underwent reperfusion therapy. | 2020-07-24 |
| 32698942 | However, interpretation and implementation of infection control guidelines is varied across Australian Radiation Therapy Departments, highlighting inconsistencies. | 2020-07-24 |
| 32698948 | Radiologists’ image reading skills vary, such variations in image interpretations can influence the effectiveness of the early treatment of disease and may have important clinical and economic implications. | 2020-07-24 |
| 32699026 | This review aims to give a brief summary of current knowledge of the epidemiology, pathophysiology, diagnosis and treatment of viral sepsis. | 2020-07-24 |
| 32699031 | Among 2,186 U.S. adults with invasive cancer and laboratory-confirmed SARS-CoV-2 infection, we examined the association of COVID-19 treatments with 30-day all-cause mortality and factors associated with treatment. […] Hydroxychloroquine with any other drug was associated with increased mortality versus treatment with any COVID-19 treatment other than hydroxychloroquine or untreated controls; this association was not present with hydroxychloroquine alone. […] Baseline COVID-19 severity was strongly associated with receipt of any treatment. […] Treatment receipt reflects clinical decision-making and suggests disparities in medication access.This article is highlighted in the In This Issue feature, p. | 2020-07-24 |
| 32699094 | However, pretreatment and posttreatment with type I and III IFNs significantly reduced virus replication in pHAE cultures that correlated with upregulation of antiviral effector genes. […] However, treatment of airway cultures with the immune molecules type I or type III interferon (IFN) was able to inhibit SARS-CoV-2 infection. | 2020-07-24 |
| 32699149 | We retrospectively compared 22 patients from three different centers in France with stages 2b and 3 COVID-19-associated pneumonia presenting with acute severe respiratory failure and systemic inflammation who received either standard-of-care treatment alone (10 patients) or combined with intravenous anakinra (12 patients). […] Treatment started at 300 mg⋅d-1 for 5 d, then tapered with lower dosing over 3 d. | 2020-07-24 |
| 32699166 | The study findings will be disseminated in peer-reviewed journals and presented at national and international conferences in order to improve the understanding of the clinical course among neonates exposed to SARS-CoV-2 and to provide evidence-based treatment and prevention strategies for this group. | 2020-07-24 |
| 32699167 | As there is no effective therapy or vaccine yet, rigorous implementation of traditional public health measures such as isolation and quarantine remains the most effective tool to control the outbreak. | 2020-07-24 |
| 32699182 | Identifying the exact cause of a pneumonitis in patients on treatment with immunotherapy is crucial to promptly start the most appropriate treatment. | 2020-07-24 |
| 32699423 | These patients do not need treatment in hospital and can be isolated at home. | 2020-07-24 |
| 32699509 | Digital technology has great potential for mental health assessment and treatment, and the improvement of personal mental performance. . | 2020-07-24 |
| 32699547 | To prevent damage to the coronary arteries, treatment should be started as soon as the diagnosis is made. […] There have been a lot of advances in medical therapy in recent years, which are reviewed together with conventional proven therapy for KD. […] Early diagnosis and prompt treatment are important to achieve optimal treatment outcome in KD. | 2020-07-24 |
| 32699612 | In the current setting of global containment, peritoneal dialysis (PD) and home haemodialysis are the best modalities of renal replacement therapy (RRT) to reduce the rate of transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. | 2020-07-24 |
| 32699615 | In this review we discuss the chronic immunologic changes observed in CKD patients, the risk of COVID-19 infections and the clinical implications for and specific COVID-19 therapy in CKD patients. | 2020-07-24 |
| 32699671 | Food and Drug Administration (FDA) has sent warning letters to CBD retailers who promoted CBD to treat Alzheimer’s disease, cancer, diabetes, and other serious conditions for which there is no evidence of its efficacy as a treatment or preventive. | 2020-07-24 |
| 32699691 | After a prolonged hospital course, she improved clinically and was able to have VV-ECMO explanted, after 18 days of extracorporeal therapy. […] The complexity of ECMO therapy requires a well-trained multidisciplinary team present only at expert centers. […] Considering the limitations of this resource-intensive therapy, clinical judgment is crucial to decide whether ECMO is an appropriate option for the patient. […] However, for young patients with no underlying conditions who are critically ill despite optimized mechanical ventilation, we believe that extracorporeal therapy represents a reasonable option when available. | 2020-07-24 |
| 32699874 | Today they are discussed as potential starting compounds for developing drug candidates and therapeutics. | 2020-07-24 |
| 32699889 | Amid this public health emergency, the urgent need for palliative care integration throughout critical care settings has never been more crucial. […] To promote palliative care engagement in critical care; share palliative care resources to support critical care nurses in alleviating suffering during the coronavirus disease 2019 pandemic; and make recommendations to strengthen nursing capacity to deliver high-quality, person-centered critical care. […] Nurses are ideally positioned to drive full integration of palliative care into the critical care delivery for all patients, including those with coronavirus disease 2019, given their relationship-based approach to care, as well as their leadership and advocacy roles. […] Nurses should focus on a strategic integration of palliative care, critical care, and ethically based care during times of normalcy and of crisis. […] Primary palliative care should be provided for each patient and family, and specialist services sought, as appropriate. […] Palliative care is critical care. | 2020-07-24 |
| 32700004 | We analyzed the clinical manifestations, laboratory test results, computed tomography (CT) images, treatment, and clinical outcomes. | 2020-07-24 |
| 32700083 | Dental patients and professionals have a high risk of the coronavirus infection and also have a huge responsibility to prevent its spread during emergency dental treatment over the period of the COVID-19 outbreak. | 2020-07-24 |
| 32700223 | As the COVID-19 pandemic continues to unfold, payers across the USA have stepped up to alleviate patients’ financial burden by waiving cost-sharing for COVID-19 testing and treatment. […] There may also be long-term sequelae of adverse events that develop in the course of COVID-19 and its treatment. | 2020-07-24 |
| 32700336 | Presently, there remains no effective vaccine or efficient treatment strategies against COVID-19. | 2020-07-24 |
| 32700555 | Until today, there is no known medication to improve clinical symptoms or even prevent or fight the infection. […] Although it has been used in the treatment of rheumatoid arthritis, discoid or systemic lupus erythematosus, and malaria prophylaxis and therapy for decades, knowledge on HCQ as a potential treatment for COVID-19 is limited and multiple clinical trials have just emerged. | 2020-07-24 |
| 32700573 | An individualized approach to medication management among hospitalized COVID-19 patients with concurrent CVDs would seem prudent with attention paid to changes in clinical conditions and medications intended for COVID-19. […] The decision to modify prescribed long-term CV medications should be entailed by close follow-up to check if a revision on the decision is needed, with resumption of any long-term CV medication before discharge if it is discontinued during hospitalization for COVID-19, to ensure continuity of care. | 2020-07-24 |
| 32700619 | Of the respondents, 4.7% and 14.0% were involved in frontline treatment for COVID-19 patients with non-orthopaedic and orthopaedic problem, respectively. […] Respondents working in Ministry of Health had highest percentage of involvement as frontliner, 7.8% (8/103) and 20.4% (21/103) for non-orthopaedic and orthopaedic related COVID-19 treatment, respectively (not significant). […] Direct exposure to treatment of COVID-19 patients among the respondent is low and the main concern was infecting their family member. | 2020-07-24 |
| 32700681 | Its severe clinical manifestations associated with the need for admission into Intensive Care Units and high mortality rate represent a therapeutic challenge for the medical community. […] Currently, there is no drug approved for its treatment and different therapeutic options are being essayed to address pathophysiological processes underlying the clinical manifestations experienced by patients. […] New and old drugs, whether as a single treatment or in combination, in immunologically compromised patients may favour the development of adverse drug reactions (ADR), including drug hypersensitivity, which must be identified and managed accordingly. | 2020-07-24 |
| 32700936 | The health threat posed by the novel coronavirus that caused the COVID-19 pandemic has particular implications for people with disabilities, including vulnerability to exposure and complications, and concerns about the role of ableism in access to treatment and medical rationing decisions. | 2020-07-24 |
| 32701249 | Identifying animal species susceptible to infection with the SARS-CoV-2/ HCoV-19 pathogen is essential for controlling the outbreak and for testing valid prophylactics or therapeutics based on animal model studies. | 2020-07-24 |
| 32701511 | The clinical characteristics, laboratory studies, and treatment response were collected. […] Immunomodulatory therapy given to patients with MIS-C included intravenous immune globulin (IVIG) (71%), corticosteroids (61%), and anakinra (18%). […] Clinical and laboratory improvement were observed in all cases, including 6 cases that did not require immunomodulatory therapy. | 2020-07-24 |
| 32701630 | We report the emergency use of immunomodulatory therapy utilizing an extracorporeal selective cytopheretic device (SCD) in two patients with elevated serum interleukin (IL)-6 levels and refractory COVID-19 ARDS requiring extracorporeal membrane oxygenation (ECMO). […] Once identified, emergency/expanded use permission for SCD treatment was obtained and patient consented. […] The two patients were successfully weaned off ECMO after 17 and 16 days of SCD therapy respectively. […] The results observed with SCD therapy on these two critically ill COVID-19 patients with severe ARDS and elevated IL-6 is encouraging. […] A multicenter clinical trial is underway with a FDA-approved Investigational Device Exemption to evaluate the potential of SCD therapy to effectively treat COVID-19 ICU patients. | 2020-07-24 |
| 32701920 | Ultimately, only 0.1% of HCWs dedicated to the treatment of COVID-19 patients contracted the infection (one was asymptomatic). | 2020-07-24 |
| 32701934 | Despite ventilation strategies, neuromuscular blockade, inhalation therapy, and vitamin C, he remained asynchronous to the ventilator with volumes and pressures beyond accepted thresholds, eventually developing a fatal tension pneumothorax. | 2020-07-24 |
| 32701969 | We measured incident Grade 3 or 4 blood count and liver test abnormalities, ventricular arrhythmias, and vomiting and diarrhea within 10 days after HCQ initiation, and the proportion of patients who completed HCQ therapy. […] Eighty-nine percent of patients completed their HCQ course and three patients discontinued therapy because of QT prolongation. […] However, nearly one-half of patients did not improve with this treatment, highlighting the need to evaluate HCQ and alternate therapies in randomized trials. | 2020-07-24 |
| 32702095 | The antiviral drug remdesivir has been shown clinically effective for treatment of COVID-19. […] Combination therapy or longer treatment duration may be needed in immunocompromised patients. | 2020-07-24 |
| 32702153 | Therefore, we conducted a search in English database from October 2019 to July 2020 and extracted data from cases with treatment details worldwide, and total of 41 recipients with a median age of 50 years were enrolled in this study. […] 68.3% received oxygen support; all patients received antiviral therapy, and 15 (36.6%) recipients were additionally treated with intravenous immunoglobulin and interferon-α. […] 19.5% of patients maintained immunosuppressive therapy; 36.6% suspended antimetabolite; and 43.9% only treated with corticosteroid. […] In all, it is necessary to pay close attention to renal function and lymphocyte count in KTRs infected with COVID-19 and choose appropriate medication programs according to the specific situations. | 2020-07-24 |
| 32702176 | Endoscopy is widely used as a clinical diagnosis and treatment method for certain hepatobiliary and pancreatic diseases. […] This article introduces preventive measures for endoscopic treatment enacted in our medical center during COVID-19, including the adjustment of indications, the application of endoscope protective equipment, the design and application of endoscopic masks and splash-proof films, and novel recommendations for bedside endoscope pre-sterilization. | 2020-07-24 |
| 32702224 | Clozapine is the most effective antipsychotic for treatment resistant schizophrenia but adverse reactions to clozapine include neutropenia. […] We report on two actively psychotic patients with treatment resistant schizophrenia who required admission to our inner-London acute psychiatric unit during the COVID-19 pandemic and who were treated with clozapine. […] One was a young patient who developed COVID-19 symptoms and tested positive for the SARS-CoV-2 virus while receiving clozapine and the other was an aging man who tested negative for the SARS-CoV-2 virus but had contact with COVID-19 during initiation of clozapine treatment. […] Both responded to clozapine treatment and were safely discharged from hospital without any complication. […] These cases suggest that, in the absence of complications, exposure to COVID-19 per se and the onset of mild symptoms in those infected may not warrant withdrawal or postponement of clozapine treatment when this is indicated. | 2020-07-24 |
| 32702311 | We applied per-day hazard ratios (HRs) for cancer progression that we generated from observational studies of delay to treatment. […] From these numbers, we estimated the aggregate number of lives and life-years lost in England for per-patient delays of 1-6 months in presentation, diagnosis, or cancer treatment, or a combination of these. | 2020-07-24 |
| 32702415 | We analyzed their clinical and demographic data, laboratory parameters, radiological findings, symptoms, and treatment outcomes. […] The overall mortality in Daegu was low, which might have resulted from large scale mass screening to detect patients and starting appropriate treatment, including hospitalization for severe cases, and quarantine for asymptomatic patients. | 2020-07-24 |
| 32702547 | Use of antimicrobials in the treatment and prevention of COVID-19, caused by novel coronavirus SARS-CoV-2, is on the rise. […] Current wastewater treatment techniques are unable to offer complete elimination of antibacterial biocides. | 2020-07-24 |
| 32702641 | The main concerns in RRMS patients were that someone that they know could be infected with COVID-19 (78.5%), or could die due to the infection (33.8%), and the lack of specific treatment options (25.8%). | 2020-07-24 |
| 32702822 | No specific anti-virus drugs or vaccines have been available for the treatment of COVID-19. […] This protocol is proposed for a systematic review and meta-analysis that aims to evaluate the efficacy of integrative traditional Chinese and western medicine treatment on patients with COVID-19. […] This study will provide a well-reported and high-quality synthesis on the efficacy of integrative traditional Chinese and western medicine treatment on patients with COVID-19. […] This systematic review protocol will be helpful for providing evidence of whether integrative traditional Chinese and western medicine treatment is an effective therapeutic approach for patients with COVID-19. | 2020-07-25 |
| 32702935 | The therapeutic schedule included aerosol inhalation of recombinant human interferon α-2b and supportive therapy. […] Strengthening infants’ virus screening in families with infected kins is important for early diagnosis, isolation, and treatment when symptoms are atypical. | 2020-07-25 |
| 32703036 | We have reviewed the literature focusing on the prevention, diagnosis, and treatment of COVID-19. […] The most relevant reports from the recent two decades were collected utilizing keywords including SARS-CoV, MERS-CoV, COVID-19, epidemiology, therapeutics and diagnosis. […] Based on this literature review, both traditional and emerging approaches are vital for the prevention, diagnosis and treatment of COVID-19. […] The traditional sciences play an essential role in the preventive and supportive care of corona infection, and modern technologies appear to be useful in the development of precise diagnosis and powerful treatment approaches for this disease. | 2020-07-25 |
| 32703085 | In this essay, we summed up our safety measures on how to protect PD patients and our staffs, and our experience on how to ensure the dialysis treatment of PD patients during the pandemic period. […] According to the patient survey, 11 patients (3.3% of the total) reduced their treatment of dialysis exchange due to the shortage of PD solution or the affection of the pandemic. | 2020-07-25 |
| 32703089 | Nine patients were on active cancer therapy during the infection and all stopped medical treatments. […] The management of patients with cancer during the pandemic should be carefully balanced and discussed among oncologists and other key professionals involved in the treatment of this vulnerable group of patients, in order to balance the risk of treatment and the risk of infection. | 2020-07-25 |
| 32703328 | Unfortunately, few studies about SARS-CoV-2 concerning its immunopathogenesis and treatment are available. | 2020-07-25 |
| 32703636 | We reviewed all relevant articles pertaining to kidney, upper tract urothelial cell, bladder, prostate, penile, and testicular cancer in regard to diagnostic, surgical, or treatment delay. […] The majority of urologic cancers rely on surgery as primary treatment. […] Treatment of unfavorable intermediate or high-risk prostate cancer, can likely be delayed for 3 to 6 months without affecting oncologic outcomes. […] Clinicians must manage emotional anxiety and stress when decisions around treatment delays are necessary as a result of a pandemic. | 2020-07-25 |
| 32703645 | The COVID-19 epidemic represents a special risk for kidney patients due to their comorbidities and advanced age, and the need for hemodialysis treatment in group rooms. | 2020-07-25 |
| 32703664 | The collection and clinical use of COVID-19 convalescent plasma (CCP) as a therapy for COVID-19 infection is under development and early use in many centers worldwide. | 2020-07-25 |
| 32703700 | Although some insurers are waiving cost-sharing payments for coronavirus disease 2019 treatment, self-insured employers remain exempt. | 2020-07-25 |
| 32703797 | Hyperimmune plasma from Covid-19 convalescent is a potential treatment for severe Covid-19. […] Five serious adverse events occurred in 4 patients (2 likely, 2 possible treatment related). | 2020-07-25 |
| 32703818 | Therefore, this approach has considerable therapeutic potential for treatment of COVID-19. | 2020-07-25 |
| 32703883 | This observational study aims to assess the outcome and safety of O2-therapy by high-flow nasal cannula (HFNC) in 28 consecutive patients with severe hypoxemic acute respiratory failure (hARF) consequent to SARS-CoV-2 infection, unresponsive to conventional O2-therapy. […] Nine patients required escalation of treatment to non-invasive ventilation (five subsequently intubated). […] These data suggest HFNC to be a safe treatment for less severe patients with SARS-CoV-2 hARF and efficacy will need to be assessed as part of a clinical trial. | 2020-07-25 |
| 32703906 | The coronavirus disease 2019 (COVID-19) pandemic has led to accelerated efforts to develop therapeutics and vaccines. | 2020-07-25 |
| 32703908 | There are no approved vaccines or therapeutics for treating COVID-19. […] Our results highlight a key role for antibody-based therapeutic interventions in the treatment of COVID-19. | 2020-07-25 |
| 32704352 | Others have shown that GM-CSF is an effective treatment for both bacterial and viral pneumonias, and their associated inflammation, in animals and that it has successfully treated pneumonia-associated Acute Respiratory Distress Syndrome in humans. […] These and other data strongly suggest that GM-CSF may be an effective treatment for many viral infections, including COVID-19. | 2020-07-25 |
| 32704354 | Methods: In this study, we present the results of molecular docking processes through high throughput virtual screening to analyze drugs recommended for the treatment of COVID-19. | 2020-07-25 |
| 32704366 | New treatment and teaching modalities emerged in response to the pandemic. | 2020-07-25 |
| 32704376 | Being frontline healthcare workers, pharmacists have experienced an increase in the number of patients seen, the amount of screening and triage being done, the amount of COVID-19 information being delivered, the number of medication shortages, and the amount of workplace harassment taking place. | 2020-07-25 |
| 32704408 | The provision of medical equipment (e.g., masks, alcohol, ventilators, medication, etc.), the reopening of schools and universities, the start of tourism and public gatherings, the provision of medical staff and preventive planning depend on the number of patients with the disease. | 2020-07-25 |
| 32704455 | Upon treatment with furosemide, LPS-induced production of pro-inflammatory cytokines was reduced, indicating that furosemide suppresses the M1 polarization, including IL-6 and TNF-α release. […] Our pre-clinical data suggest that it may be a candidate for repurposing as an inhaled therapy against COVID-19. | 2020-07-25 |
| 32704470 | Due to the risk of cross - infection involved within in the dental setting, the dental professional is even scared to provide emergent treatment for a patient. | 2020-07-25 |
| 32704471 | Based on the 6th edition of the COVID-19 treatment plan, the patient met the discharge standards after treatment and was discharged after consultation with the expert panel. | 2020-07-25 |
| 32704472 | The patient developed a severe macrophage activation syndrome diagnosed by bone marrow biopsy, which did not respond to immunoglobulin therapy. | 2020-07-25 |
| 32704477 | All five women were outpatients with mild or moderate forms of COVID-19 and were not taking any medication. | 2020-07-25 |
| 32704548 | Introduction: Vaccines and drugs for the treatment and prevention of COVID-19 require robust evidence generated from clinical trials before they can be used. | 2020-07-28 |
| 32705115 | Ultimately, our institution developed a 140-medication field hospital formulary, a process to enable appropriate use of nonformulary drugs, and a mixed operations model including automated dispensing cabinets and a manual cart-fill process. […] A methodical approach to developing limited formularies and pharmacy operations in a field hospital setting will allow health systems to establish efficient and effective medication distribution services in the event of a second surge of COVID-19 cases. | 2020-07-25 |
| 32705298 | The new severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has far reaching effects on society, the economy and medical treatment. […] Mutations can impair the diagnostics and treatment, which makes monitoring necessary. | 2020-07-25 |
| 32705370 | Optimal support for PLWH and SUD is critical during pandemics like COVID-19, as drug-related and HIV antiretroviral therapy (ART) non-adherence risks such as overdose, unsafe sexual behaviors, and transmission of infectious diseases may unfold. | 2020-07-25 |
| 32705718 | Promoting awareness of COVID-19-related ICD is vital to highlight prevention and treatment for frontline staff. | 2020-07-25 |
| 32705860 | This paper improves the methodology of the first edition of the rapid living systematic review started in April 2020, with the aim to gather and present the current evidence informing rehabilitation of patients with COVID-19 and/or describing the consequences due to the disease and its treatment. | 2020-07-25 |
| 32705880 | The mortality rates of vulnerable and minority populations alone suggest a need to re-evaluate clinical decision making protocols, especially given the recently passed Emergency or Disaster Treatment Protection Act, which grants healthcare institutions full immunity from liability stemming from resource allocation/triage decisions. […] Finally, we make the claim that the state must successfully develop ones that ensure the just treatment of our most vulnerable. | 2020-07-25 |
| 32705889 | We document the demographics, symptoms experienced, medications required, effectiveness observed, and challenges to high-quality holistic palliative care in 31 patients. […] A retrospective survey was conducted of patients referred to the hospital palliative care service in a tertiary hospital, south east of England between March 21 and April 26, 2020. | 2020-07-25 |
| 32705942 | The five identified drugs could be evaluated experimentally as inhibitors of the SARS-CoV-2 main protease in view of a possible COVID-19 treatment. | 2020-07-25 |
| 32705945 | A telephone survey was conducted in May 4-10 2020 about the Italian lockdown period (March 9-May 3 2020) in a cohort of psoriatic patients treated with biologics, asking about any exposure to COVID-19, disease status, continuation of therapy, work activity and psychological status through Hospital Anxiety and Depression Scale (HADS), Perceived Stress Scale (PSS) and Brief Resilience Scale (BRS). 226 patients were interviewed, with no COVID-19 positive cases. | 2020-07-25 |
| 32705962 | The scarcity of appropriate medical treatment and no effective vaccine or medicine against SARS-CoV-2 has turned the situation worst. | 2020-07-25 |
| 32705976 | The search for new or repurposed drugs for treatment of COVID-19 continues. […] Derivatives from the herb Artemisia annua have been used as traditional medicine over centuries for the treatment of fevers, malaria, and respiratory tract infections. | 2020-07-25 |
| 32705981 | The treatment of affective bipolar disorder and schizophrenia have now added increased difficulties. […] Some psychotropic drugs interfere with the pathophysiology of the novel coronavirus infection and they could interact with the drugs used in the treatment of COVID-19. […] The regular treatment of mentally ill patients with COVID-19 presents increased complexity. | 2020-07-25 |
| 32705994 | For instance, the disease has interrupted the provision of Speech-Language Pathology (SLP) services to children due to the need for face-to-face communication between Speech and Language Pathologists (SLPs) and children during the evaluation and treatment processes. | 2020-07-25 |
| 32706088 | There is no antiviral therapy and only symptomatic care. | 2020-07-25 |
| 32706108 | There is currently no treatment for COVID-19, therefore the key therapeutic intervention centers around the symptomatic treatment of respiratory failure. […] In some patients, conventional (passive) oxygen therapy alone is sufficient. […] In patients with worsening respiratory failure high flow nasal oxygen therapy (HFNOT) may be effective. […] The authors of this article set themselves the goal of presenting the most current knowledge about the epidemiology and patho-physiology of respiratory failure in COVID-19, as well as the methods of its treatment. | 2020-07-25 |
| 32706216 | Consideration of thrombolysis as first-line reperfusion therapy in patients with COVID-19 and STEMI is recommended by ACC/SCAI guidelines. […] Our case illustrates that thrombolytic therapy alone may not be adequate in patients with STEMI and COVID-19, as well as the importance of early invasive hemodynamics in management of shock in patient with STEMI and COVID-19 infection. | 2020-07-25 |
| 32706293 | This review highlights the important considerations related to the CV manifestations of COVID-19 infections, describes the mechanisms and clinical presentation of CV injury, and provides practical management and therapy suggestions. | 2020-07-25 |
| 32706299 | To explore patterns of mortality during the COVID-19 pandemic and implications for palliative care, service planning and research. […] The COVID-19 pandemic has led to a surge in palliative care needs. […] Health and social care systems must ensure availability of palliative care to support people with severe COVID-19, particularly in care homes. | 2020-07-25 |
| 32706390 | There are numerous ongoing studies assessing treatment options for preventing, treating, and managing complications of coronavirus disease-2019 disease. […] There are 134 different drug-based interventions being assessed in 463 clinical trials as treatment options China accounts for 35% of all ongoing clinical studies followed by USA 23% and other countries together account for 42%. […] Amongst the 463 studies assessing drug-based treatment options, studies that are funded by federal and academic institutions are 79.6%, pharmaceutical company-funded studies are 15.11%, and no funding information is available in 5.10%. | 2020-07-25 |
| 32706409 | There was no significant difference between SARS-CoV-2 positive or negative patients for age distribution, gender, time with HIV infection, nadir CD4-cell counts, type and number of co-morbidities, current CD4 and CD8 counts and type of anti-HIV therapy. | 2020-07-25 |
| 32706411 | The pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-Cov-2) has led to the elaboration of multiple studies to increase knowledge and understanding, hence, having the ability to accomplish an adequate and timely diagnosis and give an optimal treatment according to the patient’s condition. […] Therefore, we consider that the search for other infections should be performed exhaustively, especially in those cases that may be susceptible to treatment such as Influenza A, human immunodeficiency virus, or bacterial infections. | 2020-07-25 |
| 32706420 | Sera losing IgG reactivity after urea treatment (n = 28) were drawn significantly earlier (P = .04) after onset of symptoms than those which preserved it (n = 48). | 2020-07-25 |
| 32706426 | These findings are of great clinical value for timely and effective treatment of the COVID-19 cases. | 2020-07-25 |
| 32706615 | The mean percentage of patients receiving endovascular therapy was 10% from April 2019 to March 2020 and increased to 19% in April 2020. | 2020-07-25 |
| 32706783 | Based on its critical role in viral replication, the viral protease can prove to be a promising “target” for antiviral drug therapy. | 2020-07-25 |
| 32706790 | Therefore, the current social distancing measures to reduce contacts will remain key in controlling the infection in the absence of vaccines and other therapeutics. | 2020-07-25 |
| 32706859 | We compared the efficacy of the antiviral agent, remdesivir, versus standard-of-care treatment in adults with severe COVID-19 using data from a phase 3 remdesivir trial and a retrospective cohort of patients with severe COVID-19 treated with standard-of-care. […] GS-US-540-5807 is an ongoing real-world, retrospective cohort study of clinical outcomes in patients receiving standard-of-care treatment (non-remdesivir-cohort). […] Stabilized inverse probability of treatment weighted multivariable logistic regression was used to estimate the treatment effect of remdesivir versus standard-of-care. […] After the inverse probability of treatment weighting procedure 312 and 818 patients were counted in the remdesivir- and non-remdesivir-cohorts, respectively. […] In this comparative analysis, by day 14, remdesivir was associated with significantly greater recovery and 62% reduced odds of death versus standard-of-care treatment in patients with severe COVID-19. | 2020-07-25 |
| 32707089 | G6PD deficiency may especially predispose to hemolysis upon coronavirus disease-2019 (COVID-19) infection when employing pro-oxidant therapy. | 2020-07-25 |
| 32707096 | Additionally, early IFN-α2b and umifenovir alone or together were associated with reduced mortality and accelerated recovery in comparison with treatment with lopinavir/ritonavir (LPV/r) alone. | 2020-07-25 |
| 32707160 | However, a number of ongoing clinical trials are investigating the efficacy and safety of the medicines which have already been registered and used for the treatment of other diseases, in the treatment of the coronavirus infection. […] The most often reported toxic effects of these medicines such as hepatotoxicity, retinal damage, nephrotoxicity, and cardiotoxicity, together with the fact that the health status of the patients with COVID-19 disease is often complicated by co-existing illnesses and therapy implicate that the decision on the therapeutic strategy should be made with caution. | 2020-07-25 |
| 32707212 | These findings provide a reference for clinicians that for COVID-19 patients with DM and the lowest decline of lymphocyte and subsets, immunomodulatory therapy as soon as possible might avoid or slow down disease progression; moreover for COVID-19 critical illness patients with or without DM and non-critical illness patients with DM, continuous immunomodulatory therapy in later stages of disease might speed up virus clearance, shorten hospital stay, improve disease prognosis in COVID-19 critical illness patients with DM. | 2020-07-25 |
| 32707213 | Lymphocytes were measured and recorded at admission and during treatment. | 2020-07-25 |
| 32707230 | A single dose of 10 U/mL interferon-β (IFNβ) pretreatment potently protected both Calu3 and Caco2 against SARS-CoV-2 infection. […] Interestingly, SARS-CoV-2 was more sensitive to the pretreatment with IFNβ and IFN inducer than SARS-CoV in Calu3. | 2020-07-25 |
| 32707264 | This pilot study aimed to evaluate the clinical efficacy of low-dose whole-lung radiation therapy in patients with COVID-19 pneumonia. […] They were followed for 5 to 7 days to evaluate the response to treatment and toxicities. | 2020-07-25 |
| 32707288 | Herein, based on publicly available genomic data, we analyzed the codon usage co-adaptation profiles of SARS-CoV-2 and other respiratory coronaviruses (CoVs) with their human host, identified CoV-responsive human genes and their functional roles on the basis of both the relative synonymous codon usage (RSCU)-based correlation of viral genes with human genes and differential gene expression analysis, and predicted potential drugs for COVID-19 treatment based on these genes. […] Using the drug-gene interaction database, we screened a list of drugs that could target these genes as potential COVID-19 therapeutics. | 2020-07-25 |
| 32707307 | For SARS-CoV-2 and other disease-causing agents we envision an aggregate wastewater-monitoring system at the level of a wastewater treatment plant and exploratory or confirmatory monitoring of the sewerage system at the neighborhood scale to identify or confirm clusters of infection or assess impact of control measures where transmission has been established. | 2020-07-25 |
| 32707480 | This position paper of the Respiratory Support and Chronic Care Group of the French Society of Respiratory Diseases is intended to help respiratory clinicians involved in care of COVID-19 pandemic in the rational use of non-invasive techniques such as oxygen therapy, CPAP, non-invasive ventilation and high flow oxygen therapy in managing patients outside intensive care unit (ICU). | 2020-07-25 |
| 32707537 | Currently, cytokine storm is one of the leading causes of morbidity and mortality in SARS-CoV-2, but there is no proven treatment to combat this systemic response. […] The aim of this paper is to study the cytokine storm response in SARS-CoV-2 and to explore the early treatment options for patients who are critically ill with the coronavirus disease (COVID-19) in the early stages of the pandemic by reviewing the literature. […] Many treatment options with different targets have been proposed during the early stages of the COVID-19 pandemic, ranging from targeting the virus itself to managing the systemic inflammation caused by the virus and the excessive cytokine response. […] Among the different agents to manage cytokine storm in patients with COVID-19, there is developing support for convalescent plasma therapy particularly for patients who are critically ill or mechanically ventilated and resistant to antivirals and supportive care. […] Treatment options that were proposed in the beginning phases of the pandemic were multidimensional, and further research is needed to develop a more established treatment guideline. | 2020-07-25 |
| 32707573 | Since most of the molecules identified in this study have already advanced into the clinic, their known pharmacological and human safety profiles will enable accelerated preclinical and clinical evaluation of these drugs for the treatment of COVID-19. | 2020-07-25 |
| 32707770 | The phase II of the COVID-19 epidemic in cancer patients needs a strategy to reduce the likelihood of infection and identify the vulnerable population, both in patients with active antineoplastic treatment and in survivors with frequently different coexisting medical conditions. | 2020-07-26 |
| 32707942 | As a result of its recent appearance (December 2019), an efficacious treatment is not yet available. | 2020-07-26 |
| 32707965 | Additionally, with the global emergence of triazole resistance, we emphasize the importance of antifungal susceptibility testing in order to ensure appropriate antifungal therapy. | 2020-07-26 |
| 32708112 | In a guarded optimistic view, we hope that the undertaken preventive and treatment measures will at least contribute to contain viral diffusion, attenuate activity, or even eliminate SARS-CoV2. […] In this review, we discuss emerging perspectives for prevention/treatment of COVID-19 infection. | 2020-07-26 |
| 32708319 | For this reason, the use of gene networks may well encourage therapy-associated research in the context of the coronavirus pandemic, orchestrating experimental scrutiny and reducing costs. | 2020-07-26 |
| 32708322 | Since EGCG can restore the natural immunological homeostasis in many different autoimmune diseases, we propose here a supplementation therapy with EGCG in COVID-19 patients. | 2020-07-26 |
| 32708334 | We conclude by looking at point-of-care devices and methodologies in COVID-19 management and suggest that a personalized medicine approach should be considered in the treatment of patients. | 2020-07-26 |
| 32708357 | The factors associated with outcomes of critically ill patients with coronavirus disease 2019 (Covid-19) who required treatment in an intensive care unit (ICU) are yet to be determined. […] The results of our multivariable model suggest that further evaluation is needed of antiviral and antibacterial agents in the treatment of sepsis and secondary infection. | 2020-07-26 |
| 32708430 | The majority of the medications used in the treatment of COVID-19 are metabolized by cytochrome P450 (CYP) enzymes, primarily CYP2D6. […] Current therapy must focus on antivirals and heme oxygenase upregulation. | 2020-07-26 |
| 32708495 | We will also provide insights and considerations for COVID-19 treatment and prevention in patients with SUDs. | 2020-07-26 |
| 32708504 | The major principles of optimal care for mild outpatient cases include a patient-tailored therapeutic approach, regular glucose monitoring and adherence to medical recommendations regarding lifestyle measures and drug treatment. […] Further research is needed to examine which subgroups of DM patients are expected to benefit the most from specific antiviral, immunomodulatory and other treatment strategies in the context of patient-tailored precision medicine, which emerges as an urgent priority in the era of COVID-19. | 2020-07-26 |
| 32708750 | The clinical and analytical spectrum and treatment responses and mortality are poorly characterized. […] Clinical and analytical features, chest X-ray, polymerase chain reaction (PCR) and antibodies for SARS-CoV-2, treatment and outcomes were analyzed in 48 patients diagnosed with COVID-19 during March and April 2020 in two coordinated Spanish hemodialysis units. | 2020-07-26 |
| 32708803 | Meanwhile, machine and deep learning models have been revolutionary across numerous domains and applications whose potency have been exploited to birth numerous state-of-the-art technologies utilised in disease detection, diagnoses, and treatment. | 2020-07-26 |
| 32708838 | The COVID-19 pandemic has had economic repercussions in dentistry as only urgent treatment was available during the State of Alarm. | 2020-07-26 |
| 32708858 | To date, most evidence has come from renal transplantation, with about 45 patients reported thus far, and the current data from the ERA-EDTA (ERACODA) registry for transplanted patients and patients on Renal Replacement Therapy (RRT); as for those with glomerular diseases, data are lacking. […] After treatment with hydroxychloroquine and azithromycin, despite his low chances, he gradually recovered and survived. | 2020-07-26 |
| 32709280 | A multicenter retrospective cohort study was conducted to analyze clinical, laboratory data and treatment of 60 severe cases with COVID-19 infection in Jiangsu Province between January 24, 2020 and April 20, 2020. […] There were no statistically significant differences in immunoglobulin therapy and GCs therapy between the improvement and deterioration subgroups. […] Logistic regression analysis identified higher levels of troponin T (odds ratio [OR]: 1.04; 95% confidence interval [CI]: 1.00-1.08; P = 0.04), antiviral therapy with aerosol inhalation of interferon (OR: 6.33; 95% CI: 1.18-33.98; P = 0.03), and the application of non-invasive mechanical ventilation (OR: 1.99; 95%CI: 1.17-3.41; P = 0.01) as predictors of disease progression, whereas higher lymphocyte count (OR: 0.11; 95% CI: 0.02-0.57; P = 0.01) and early prone ventilation were associated with improvement (OR: 0.11; 95% CI: 0.01-0.98; P = 0.04). […] Early prone ventilation may be an effective treatment for severe cases. | 2020-07-26 |
| 32709413 | Immunosuppressive therapy was modulated, and intravenous corticosteroids and potentially effective antiviral therapy were administered with a favorable outcome. | 2020-07-26 |
| 32709482 | Data collection included clinical presentation, laboratory and radiological findings, treatment and outcome. | 2020-07-26 |
| 32709495 | The International Society of Geriatric Oncology (SIOG) formed a panel of experts to develop consensus recommendations on the implications of the pandemic on several aspects of cancer care in this age group including geriatric assessment (GA), surgery, radiotherapy, systemic treatment, palliative care and research. […] GA may aid estimating physiologic reserve and adaptive capability, assessing risk-benefits of either providing or temporarily withholding treatments, and determining patient preferences to help inform treatment decisions. | 2020-07-26 |
| 32709505 | Of patients with BC, 46.2% had to modify planned necessary anti-cancer treatment during the outbreak. […] Poor physical condition and treatment discontinuation were underlying risk factors for distress based on multivariable analysis. […] Special attention should be paid to the psychological status of patients with BC, especially those with poor general condition, treatment discontinuation, aggressive molecular subtypes, and metastatic BC. | 2020-07-26 |
| 32709637 | Outcome measures were level of oxygen therapy, discharge and death. […] Patients were followed up until 21 April 2020. 108 patients were included. 34 (31%) died in hospital or were discharged for palliative care. 43% of patients aged over 65 died. | 2020-07-26 |
| 32709734 | Treatment with steroids allowed a rapid improvement of symptoms. | 2020-07-26 |
| 32709770 | Records of all the patients who presented from March 25th to May 3rd, 2020 were scanned to evaluate the details regarding the presenting complaints, diagnosis, advised treatment and surgical interventions. […] A significant number of patients could not get adequate treatment during the lockdown period. | 2020-07-26 |
| 32709887 | 2’-O-RNA methyltransferase (MTase) is one of the enzymes of this virus that is a potential target for antiviral therapy as it is crucial for RNA cap formation; an essential process for viral RNA stability. | 2020-07-26 |
| 32709978 | Efforts were combined since then to rapidly develop a treatment and/or a vaccine to combat the deadly virus. | 2020-07-26 |
| 32710161 | The mortality of patients with the disease escalates, particularly at the moment when the treatment possibilities of intensive medical care end. […] In the routine intensive medical care practice, the challenges due to the special features of infections with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and its treatment become obvious. […] These occur in the development and treatment of respiratory and multiorgan failure as well as the severe inflammatory syndrome. […] In addition to the knowledge that can be gained from the rapid performance of clinical trials, the treatment is therefore based on analogies to other syndromes, such as sepsis and macrophage activation syndrome. | 2020-07-26 |
| 32710269 | Without a specific antiviral treatment or vaccine, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused a global pandemic, affecting over 200 countries worldwide. […] A better understanding of B- and T-cell immunity is critical to the diagnosis, treatment and prevention of coronavirus disease 2019 (COVID-19). | 2020-07-26 |
| 32710297 | Such programs include diagnostic procedures (spirometry, ECG, blood tests) and treatments like respiratory physio-kinesiotherapy and postural drainage of the lungs; mechanical pulmonary ventilation for rehabilitative purposes, with or without drugs, along with standard medical and, when required, oxygen therapy; inhalation therapies with mineral waters; physical activity and psychological support. | 2020-07-26 |
| 32710359 | A panel of doctors and nursing staff should review COVID-19 patients with higher BMI with other co-morbidities (diabetes and hypertension), and they should be given increased vigilance, priority in testing, and treatment to control the associated co-morbidities. | 2020-07-26 |
| 32710500 | Active chemotherapy, viral load at diagnosis and COVID-19 therapy were not predictors of outcome. | 2020-07-26 |
| 32710571 | We review several current and potential genetic (DNA) and transcriptional (RNA)-based parameters in women with infertility that can be significant in diagnosis and treatment. | 2020-07-26 |
| 32710599 | In this pandemic period, 44 of 54 patients were recommended to continue their previous treatment. […] While the dose of medication used by 7 patients was reduced, it was decided to change the treatment of 3 patients. […] This article is important in terms of being the first study in the literature examining the treatment of patients with Behçet’s disease during the COVID-19. […] In this period, we know that the treatment practices in chronic diseases change frequently daily, and in this respect, we hope that our study will provide a perspective to other dermatology clinics in terms of the treatment of Behçet’s disease during the pandemic. | 2020-07-26 |
| 32710693 | Understanding pediatric-specific acute and delayed immune responses to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is critical for the development of vaccination strategies, immune-targeted therapies, and treatment and prevention of multisystem inflammatory syndrome in children. | 2020-07-26 |
| 32710732 | No specific curative therapy is available for CoVid-19. | 2020-07-26 |
| 32710774 | We describe our approach to adapting the pharmacy leadership structure to address critical medication shortages through innovative data analysis, procurement strategies, and rapid implementation of medication policy. […] By refining a model to project health-system medication needs, we were able to anticipate challenges and devise alternative treatment algorithms. […] With medication shortages posing a threat to patient care, dynamic pharmacy leadership proved essential to providing patient care at the height of the COVID-19 pandemic. […] System alignment and the rapid adaption of the existing framework for drug shortage management and medication use policy were crucial to success in crisis response. | 2020-07-26 |
| 32710969 | In most cases, and due to the urgency imposed by the number and severity of the patients’ clinical conditions, the choice of treatment has been limited to repurposed drugs, approved for other indications, or investigational agents used for other viral infections often rendered available on a compassionate-use basis. […] In several months, an exceptionally large number of clinical trials have been designed to evaluate the safety and efficacy of anti-COVID-19 therapies in different clinical settings (treatment or pre- and post-exposure prophylaxis) and levels of disease severity, but only few of them have been completed so far. | 2020-07-26 |
| 32711003 | This paper also provides recommendations and guidelines for which could be useful for prevention and treatment of diabetic patients affected by COVID-19. | 2020-07-26 |
| 32711058 | The majority of these patients may not require empirical antibacterial treatment. | 2020-07-26 |
| 32711111 | Hundreds of clinical trials on existing approved drugs from different classes acting on a multitude of targets in the virus life cycle are ongoing to examine potential effectiveness for the prevention and treatment of the infection. […] The viral life cycle provides potential targets for drug therapy. | 2020-07-26 |
| 32711241 | Efforts should be made to prospectively collect data, to identify effective interventions to guide treatment decision. | 2020-07-26 |
| 32711297 | Alemtuzumab is a treatment for highly active multiple sclerosis (MS). […] We describe the clinical and immunological evolution of two MS patients under alemtuzumab treatment who were affected by COVID-19, one of them only one week after receiving her last dose, and both recovered without sequelae. […] In selected patients (young, without comorbidities, and with high activity), MS itself could be more dangerous than COVID-19, so we should consider continuing MS treatment as previously planned, including alemtuzumab. | 2020-07-26 |
| 32711332 | This paper, provides a review of the literature on the occurrence of coronaviruses in wastewater treatment processes. […] We also reviewed the literature on the presence, survival and potential removal of coronaviruses in common wastewater treatment processes. […] We, therefore, highlighted the potential risk of infection with coronaviruses for workers in wastewater treatment plants and the public that may be exposed through faulty plumbing or burst sewer networks. | 2020-07-26 |
| 32711503 | Appropriate public risk communication and public advocacy strategies should be implemented to strengthen the understanding that reporting on travel history facilitates infection screening and prompt treatment, and to decrease the fear of potentially becoming quarantined after reporting. | 2020-07-27 |
| 32711839 | This new tool can be used to evaluate the severity and progression of the main disease, other comorbidities, and the urgency of the surgical treatment as well as preferencing anesthetic procedures. | 2020-07-27 |
| 32711848 | Characterizing how KTRs may present differently than the general population would allow for more targeted and timely evaluation and treatment of KTRs with COVID-19 infection. […] In addition, 16 (80%) of the 20 patients who tested positive required inpatient treatment. | 2020-07-27 |
| 32712049 | Screening of coagulatory parameters upon admission and during entire course of treatment is recommended, especially those who are at increased risk of thrombosis. […] Also, anticoagulant treatment can be used as thromboprophylaxis measure. […] Dose and duration of anticoagulation treatment requirement may vary and thus regular monitoring is needed. | 2020-07-27 |
| 32712069 | Those working at intensive care units (ICUs) or in departments of respiratory medicine (RM) demonstrated significantly higher perceived stress than those at other departments (adjusted mean: 17.48 ± 0.96 vs. | 2020-07-27 |
| 32712122 | Of these, 214 were admitted to isolation wards and 41were admitted to intensive care units (ICUs). […] Demographic, clinical, treatment, and laboratory data were collected and compared between ICU and non-ICU patients. | 2020-07-27 |
| 32712272 | Inhalation of nitric oxide (NO) gas is currently being investigated as a treatment for patients with moderate to severe COVID-19. | 2020-07-27 |
| 32712333 | This systemic review and meta-analysis aimed to assess the efficacy of tocilizumab for the treatment of severe coronavirus disease 2019 (COVID-19). […] Treatment outcomes included mortality, risk of intensive care unit (ICU) admission and the requirement for mechanical ventilation (MV). | 2020-07-27 |
| 32712334 | The aim of this study was to compare ribavirin therapy versus supportive therapy only for patients with severe coronavirus disease 2019 (COVID-19). […] The 115 patients comprised 44 patients who received intravenous ribavirin (treatment group) and 71 who did not (control group). […] In conclusion, in patients with severe COVID-19, ribavirin therapy is not associated with improved negative conversion time for SARS-CoV-2 test and is not associated with an improved mortality rate. | 2020-07-27 |
| 32712629 | Moreover, rational management of the immune responses to SARS-CoV-2, which includes enhancing anti-viral immunity while inhibiting systemic inflammation, may be key to successful treatment. | 2020-07-27 |
| 32712670 | Does HIV protease inhibitor (PI)-based combination antiretroviral therapy (cART) initiated at periconception affect key events in early pregnancy, i.e. decidualization and spiral artery remodeling? […] C57Bl/6 female mice (four/treatment group) were administered either lopinavir-cART, darunavir-cART or water by oral gavage once daily starting on the day of plug detection until sacrifice. […] Lopinavir-cART treatment was also associated with selective depletion of uNK cells, reduced trophoblast migration and defective placentation. | 2020-07-27 |
| 32712675 | Utilization of hydroxychloroquine, chloroquine, and supportive therapy drugs in hospitals in New York during the early weeks of the coronavirus disease 2019 (COVID-19) pandemic was analyzed. […] The increased utilization of supportive therapy drugs was consistent with the surge in patients with presumed or confirmed COVID-19 during the study period. | 2020-07-27 |
| 32712704 | The treatment of surgical patients who are confirmed or suspected of coronavirus disease 2019 (COVID-19) is a challenge for all anesthesiologists. | 2020-07-27 |
| 32712708 | To assess the treatment position of all patients who have had an anti-VEGF injection in 2020, prior to the UK lockdown on 23 March. […] Of the patients receiving treatment to one eye, 57.6% was receiving treatment to their worse seeing eye. […] Assessing the treatment position of patients prior to COVID-19 lockdown enables objective stratification for prioritization for continued treatment. | 2020-07-27 |
| 32712775 | In the absence of effective treatment options, the recent SARS-CoV2 pandemic poses a great challenge to the health and social sectors worldwide. | 2020-07-27 |
| 32712878 | Published data and multidisciplinary clinical judgement were used to assign risk scores based on patient and tumor factors, length of delay, and tumor response to preoperative therapy. […] Among patients receiving neoadjuvant endocrine therapy or no medical therapy, higher scores were assigned for low-estrogen receptor or high-genomic risk scores, higher grade, larger tumors, younger age and longer delay. […] High priority scores were assigned for progression during preoperative therapy. | 2020-07-27 |
| 32713239 | The increasingly common presence of cardiovascular disease in patients during or after cancer treatment led to the rapid growth of the field of cardio-oncology with a mandate of identifying, treating, and preventing the various forms of cardiovascular disease seen among this population. | 2020-07-28 |
| 32713282 | Everyday nephrologists see patients with hypertension, chronic kidney disease, maintenance dialysis treatment or kidney transplant who are also high-risk groups for the COVID-19. | 2020-07-28 |
| 32713374 | Clozapine, an antipsychotic with unique efficacy in treatment-resistant psychosis, is associated with increased susceptibility to infection, including pneumonia. […] To investigate associations between clozapine treatment and increased risk of COVID-19 infection in patients with schizophrenia-spectrum disorders who are receiving antipsychotic medications in a geographically defined population in London, UK. […] People who were on clozapine treatment were compared with those on any other antipsychotic treatment for risk of contracting COVID-19 between 1 March and 18 May 2020. […] We tested associations between clozapine treatment and COVID-19 infection, adjusting for gender, age, ethnicity, body mass index (BMI), smoking status and SLAM service use. […] Individuals who were on clozapine had increased risk of COVID-19 infection compared with those who were on other antipsychotic medication (unadjusted hazard ratio HR = 2.62, 95% CI 1.73-3.96), which was attenuated after adjusting for potential confounders, including clinical contact (adjusted HR = 1.76, 95% CI 1.14-2.72). […] These findings provide support for the hypothesis that clozapine treatment is associated with an increased risk of COVID-19 infection. | 2020-07-28 |
| 32713385 | Absolute isolation and atraumatic restorative therapy techniques are a good alternative to decrease fluid exposure. | 2020-07-28 |
| 32713387 | This is the case for the use of noninvasive positive pressure ventilation and continuous airway pressure ventilation, combined with prone position in patients with COVID-19 and acute respiratory distress syndrome treated outside of intensive care units. | 2020-07-28 |
| 32713389 | As the largest obstetrics and gynecology hospital in North China, here we summarize the diagnosis and treatment process and key points of obstetrics and gynecology patients in our hospital during the period of the COVID-19 pandemic, hoping to provide available information to inform care of obstetrics and gynecology patients. | 2020-07-28 |
| 32713658 | Statistical analysis was conducted on the number of admissions for urolithiasis, rate of complications, hospitalization and the type of treatment received. 304 patients were included in the analysis. […] Moreover, regarding the choice of treatment of hospitalized patients, a statistically significant increase of stone removal procedures versus urinary drainage was reported in 2020 (p = 0.015). | 2020-07-28 |
| 32713784 | Tocilizumab is an IL-6 receptor-blocking agent proposed for the treatment of severe COVID-19. […] The aim of this systematic review was to describe the rationale for the use of tocilizumab for the treatment of COVID-19 and to summarize the available evidence regarding its efficacy and safety. | 2020-07-28 |
| 32713821 | Treatment with low-molecular-weight heparin and aspirin was prescribed. | 2020-07-28 |
| 32713924 | Neurological disorders including GBS should be considered when intubated SARS-CoV-2 patients present with a loss of cough reflex during the treatment period. | 2020-07-28 |
| 32714077 | Several risk factors were confirmed to significantly improve the risk of exacerbation in patients with NCIP, which was very important for the exacerbation prediction and treatment of these patients. | 2020-07-28 |
| 32714083 | This article introduced the origin, virological characteristics and epidemiological overview of SARS-CoV-2, reviewed the currently known drugs that may prevent and treat coronavirus, explained the characteristics of the new coronavirus and provided novel information for the prevention and treatment of COVID-19. | 2020-07-28 |
| 32714335 | As the world is severely affected by COVID-19 pandemic, the use of chloroquine and hydroxychloroquine in prevention or for the treatment of patients is allowed in multiple countries but remained at the center of much controversy in recent days. […] This duality could explain the discrepancy with the recently published studies on CQ/HCQ treatment efficacy in COVID-19 patients. | 2020-07-28 |
| 32714386 | In this paper, we aimed at reviewing the current knowledge about COVID-19 infectious risk status in inflammatory bowel disease (IBD) patients requiring immunosuppressive medication. […] PubMed electronic database was interrogated for relevant articles involving data about common molecular pathways and shared treatment strategies between SARS-CoV-2, SARS-CoV-1, MERS-CoV, and inflammatory bowel diseases. […] Second, IBD medication was discussed in the context of possible beneficial effects on COVID-19 pathogeny, including “cytokine storm” prevention and treatment, immunomodulation, interferon signaling blocking, and viral endocytosis inhibition. […] Whether our findings are entirely applicable to the pathogenesis, disease susceptibility, and treatment management of SARS-CoV-2 infection in IBD must be further explored. | 2020-07-28 |
| 32714688 | Although no antiviral treatments have been approved, several approaches have been proposed, and at present, optimized supportive care remains the mainstay of therapy. | 2020-07-28 |
| 32714705 | The multimodal therapy mentioned above resulted in the improvement of his general condition, including acute respiratory distress syndrome (ARDS). […] In this report, we discuss the benefits of ECMO and immune modulation therapy in the treatment of severe ARDS. | 2020-07-28 |
| 32714844 | A preterm emergency Caesarean section was performed, after steroid treatment for foetal lung maturation. | 2020-07-28 |
| 32714873 | Responses were analyzed in relation to responders’ age, sex, and clinical status (advanced/metastatic disease undergoing systemic treatment vs. stable metastatic thyroid cancer in active surveillance vs. low-risk thyroid cancers with no evidence of structural disease during standard follow-up). | 2020-07-28 |
| 32714874 | As immune checkpoint inhibitors (ICIs) constitute the therapeutic backbone for the vast majority of patients with advanced lung cancer in the absence of actionable driver oncogenes, there have been intense discussions within the oncology community regarding risk-benefit of delaying these treatments or use of alternative extended-interval treatment strategies to minimize the risk of viral transmission secondary to unintended nosocomial exposures. | 2020-07-28 |
| 32715080 | Novel virus also cause chronic damage to the cardiovascular system, and attention should be given to cardiovascular protection during treatment for COVID-19. | 2020-07-28 |
| 32715376 | After 6 days of treatment in ICU, he was extubated. […] Our experience of these two cases indicates that anti-cytokine therapy might be effective for severe COVID-19 pneumonia in ESRD patients. | 2020-07-28 |
| 32715460 | Cancer cases high-risk for stage progression and surgical emergencies, were elected to proceed directly to treatment. | 2020-07-28 |
| 32715661 | Current trials of therapeutics are largely focused on the inhibition of viral processes. | 2020-07-28 |
| 32715776 | Deescalation of systemic and radiation therapy can be utilized safely in selected clinical scenarios. | 2020-07-28 |
| 32715804 | She received lopinavir/ritonavir and azithromycin as well as early methyl prednisolone therapy. […] Given the persistent hypoxemia despite oxygen therapy via non rebreather face mask (FiO2:80%), convalescent plasma transfusion was administered that led to a mild clinical improvement as well as decrease in inflammatory markers. […] Judicious corticosteroid therapy along with convalescent plasma transfusion to suppress viremia and cytokine storm can lead to favorable outcome in the pregnant women with ARDS caused by SARS-CoV2 infection without superimposed bacterial infection. | 2020-07-28 |
| 32715956 | Still, no drugs are available for its treatment. | 2020-07-28 |
| 32715960 | The ever-vulnerable medication supply chain is being further strained by the COVID-19 pandemic. | 2020-07-28 |
| 32716009 | Treatment and management for pregnant patients infected with COVID-19 has been poorly described in the literature. | 2020-07-28 |
| 32716217 | In the stepwise regression analysis of anti-hypertensive medications, none of the therapy predicted the composite endpoint. […] Anti-hypertensive therapy did not affect patient outcomes. | 2020-07-28 |
| 32716647 | While there are studies under way to characterize the direct effects of the COVID-19 pandemic on the care of patients with cancer, there have been few quantitative reports of the impact that efforts to control the pandemic have had on the normal course of cancer diagnosis and treatment encounters. | 2020-07-28 |
| 32716818 | Time to presentation, stroke severity, and time to treatment were unchanged. | 2020-07-28 |
| 32716826 | The coronavirus disease 2019 (COVID-19) pandemic has in some regions overwhelmed the capacity and staffing needs of healthcare systems, necessitating the provision of resources and staff from different disciplines to aid COVID treatment teams. […] Stroke centers have multidisciplinary clinical and procedural expertise to support COVID treatment teams. | 2020-07-28 |
| 32716828 | Since these measures have been put in place, anecdotal reports describe a decrease in the number of endovascular therapy (EVT) treatments for acute ischemic stroke due to large vessel occlusion. | 2020-07-28 |
| 32716898 | The advantages of virtual clinics include reduced treatment burden, improved therapeutic alliances, societal and psychological benefits, and in our experience, innovative solutions to overcome the challenges presented by the transition from in-person to virtual care. | 2020-07-28 |
| 32716900 | Advance care planning is the process of discussing health care treatment preferences based on patients’ personal values, and it often involves the completion of advance directives. […] Patient portals are an important tool for providing advance care planning resources and documenting medical decision makers during the pandemic to ensure that medical treatment aligns with patient goals and values. | 2020-07-28 |
| 32717066 | We conducted logistic regression analysis to estimate odds ratio (OR) with 95% confidence intervals (CI) using inverse probability of treatment weighting to minimize confounding. | 2020-07-28 |
| 32717116 | A further level of complexity opens up as soon as we look at diseases whose pathogenesis and therapy involve different immunological signaling pathways, which are potentially affected by COVID-19. […] Thus, following these patterns of skin inflammation, our review may supply treatment recommendations and thoughtful considerations for disease management even beyond the most frequent diseases discussed here. | 2020-07-28 |
| 32717282 | This includes the encapsulation and transport of specific drugs, as adjuvants to stabilize proteins, vaccines or other molecules involved in the infection, as cholesterol trappers to destabilize the virus envelope, as carriers for RNA therapies, as direct antiviral drugs and even to rescue blood coagulation upon heparin treatment. | 2020-07-28 |
| 32717321 | COVID-19 caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is devastative to the humankind for which neither vaccines nor precise therapeutic molecules for treatment are identified. | 2020-07-28 |
| 32717346 | This work provides enough evidence for further implementation of the identified compounds in the development of effective therapeutics of COVID-19. | 2020-07-28 |
| 32717367 | Palliative care (PC) workers have been an essential part of the COVID-19 response in advising on goals of care, symptom management and difficult decision making, and in supporting distressed health care workers, patients, and families. | 2020-07-28 |
| 32717432 | © 2020 American Society for Transplantation and Cellular Therapy. | 2020-07-28 |
| 32717504 | Individuals with opioid use disorder may be at heightened risk of opioid overdose during the COVID-19 period of social isolation, economic distress, and disrupted treatment services delivery. | 2020-07-28 |
| 32717568 | The urgent need to control the disease, combined with the lack of specific and effective treatment modalities, call for the use of FDA-approved agents that have shown efficacy against similar pathogens. […] We discuss a number of other drugs that are currently in clinical trials, whose results are not yet available, and in various instances we enrich such efficacy analysis by invoking historic data on the treatment of SARS, MERS, influenza, or in vitro studies. | 2020-07-28 |
| 32717596 | Finally, guidelines on the most appropriate waste treatment are presented and analyzed. | 2020-07-28 |
| 32718020 | This is primarily because of the lack of vaccines to protect against the infection and the lack of highly effective therapeutics to prevent and/or treat the illness. […] Nevertheless, researchers have swiftly responded to the pandemic by advancing old and new potential therapeutics into clinical trials. […] In this review, we summarize potential anti-COVID-19 therapeutics that block the early stage of the viral life cycle. […] The review presents the structures, mechanisms, and reported results of clinical trials of potential therapeutics that have been listed in clinicaltrials.gov. […] Given the fact that some of these therapeutics are multi-acting molecules, other relevant mechanisms will also be described. […] The reviewed therapeutics include small molecules and macromolecules of sulfated polysaccharides, polypeptides, and monoclonal antibodies. […] The potential therapeutics target viral and/or host proteins or processes that facilitate the early stage of the viral infection. […] Overall, the review aims at presenting update-to-date details, so as to enhance awareness of potential therapeutics, and thus, to catalyze their appropriate use in combating the pandemic. | 2020-07-29 |
| 32718042 | The narrow specificity of conventional vaccines and the drug resistance of currently circulating viruses reduce the effectiveness of prophylaxis and treatment and require the development of new broad-spectrum preparations. | 2020-07-29 |
| 32718086 | The inflammatory pathways in which IL-6 is involved are also partly responsible of the development and progression of rheumatoid arthritis (RA), opening interesting perspectives in terms of therapy. […] In this review we discuss the main immunologic aspects that make anti-IL-6 a good candidate in RA, but despite the main therapeutic options available to target IL-6, no gold standard treatment has been established so far. | 2020-07-29 |
| 32718127 | We evaluated the role of a combined effort of early hospitalization in combination with early antiviral therapy with COVID-19 patients in a tertiary care university hospital. | 2020-07-29 |
| 32718128 | A wide variety of treatment options are being considered for COVID-19, but there is still no definitive treatment or vaccine. […] This review aims to explain the background of the convalescent plasma treatment and its relations with COVID-19 immunity, to define the ideal treatment procedures and to reveal present and future perspectives in the light of rapidly growing data. […] Immunological basis of COVID-19 associated immune response and convalescent plasma as a treatment option: Since it has been shown that the impaired immune response of the host is one of the most important factors that increase the severity of the infection, treatment strategies to suppress aberrant immune activation are being dwelled on. […] Conclusion and future perspectives: Even though mechanisms of action of plasma therapy are not fully delineated, it has been shown that it could lead to a reduction in mortality since other alternatives such as monoclonal antibodies or SARS-CoV-2 hyper immunoglobulin require much more time and effort to be developed. | 2020-07-29 |
| 32718282 | IBD is a common and troublesome disease that still lacks effective therapy and imaging options. […] As an attempt to improve the disease treatment, we tested αMSH for the targeting of nanoliposomes to IBD sites. αMSH, an endogenous tridecapeptide, binds to the melanocortin-1 receptor (MC1-R) and has anti-inflammatory and immunomodulating effects. | 2020-07-29 |
| 32718300 | Thus, screening of potential arsenic drugs would help in providing the fast invitro to in-vivo analysis towards development of therapeutics against SARS-CoV-2. | 2020-07-29 |
| 32718425 | Of the smokers who were ready to quit, 50 (37.31%) accepted referral for smoking cessation counseling, treatment, or both. […] Only 13 (9.70%) of the 134 smokers were already receiving treatment. | 2020-07-29 |
| 32718560 | This small molecule, which has been evaluated in multiple Phase 1-2 clinical trials for cancer as well as a Phase 3 clinical trial for the treatment of small cell lung cancer called REPLATINUM (NCT03699956), is minimally toxic and demonstrates clear evidence of antitumor activity. | 2020-07-29 |
| 32718669 | Furthermore, due to their immunomodulatory properties, they have been used in the treatment of various infectious diseases such as community-acquired pneumonia and influenza. […] In this review we analyze the pathophysiological foundations that support the use of statins as an adjunctive treatment in patients with COVID-19. | 2020-07-29 |
| 32718670 | Although we lack enough evidence to justify supplementing with vitaminD in the prevention and treatment of COVID-19 infection, it is increasingly feasible that this hypothesis is valid. | 2020-07-29 |
| 32718715 | Currently, there is no treatment approved for COVID-19. | 2020-07-29 |
| 32718719 | COVID-19 patients over 18 years of age, admitted to hospital and under treatment with LPV/r were included. […] A screening of potential interactions related to LPV/r and home and hospital medication was carried out. […] The prevalence of potential interactions in COVD-19 patient undergoing treatment with LPV/r is high, with age (> 65), ICU admission, previous respiratory and psychiatric pathology, dyslipidemia and the number of prescribed drugs acting as risk factors. | 2020-07-29 |
| 32718772 | Thoracic surgeons will need to recalibrate their approach to ensure that patients receive timely and effective treatment for early stage NSCLC. […] This article will address the current challenges with treating early stage NSCLC during the COVID-19 pandemic and provide a clinical framework for providing effective surgical therapy while mitigating the risk of transmission of the SARS-CoV-2 virus to patients and surgeons. | 2020-07-29 |
| 32718781 | Doubts have been raised regarding lipid therapy in these patients. […] The objectives are to analyze the efficacy and safety of lipid lowering therapy in patients with COVID-19. […] Patients treated with iPCSK9 should continue treatment for its beneficial effects in preventing cardiovascular disease. […] Patients with familial hypercholesterolemia and COVID-19 are especially vulnerable to cardiovascular disease and should continue to receive severe lipid lowering therapy. […] In these patients, intensive treatment with statins and/or fixed combination with ezetimibe and/or iPCSK9 plays a fundamental role. | 2020-07-29 |
| 32718894 | Timely medical treatment and clear diagnosis after the onset might be beneficial to control the condition of COVID-19. | 2020-07-29 |
| 32718896 | The accurate detection of SARS-CoV-2 through respiratory sampling is critical for the prevention of further transmission and the timely initiation of treatment for COVID-19. | 2020-07-29 |
| 32719045 | At baseline all patients with COVID-19 in the treatment group (n=86) and control group (n=86) had symptoms of CSS and faced acute respiratory failure. […] Treatment effects remained constant in confounding and sensitivity analyses. | 2020-07-29 |
| 32719218 | Tocilizumab (TCZ), an interleukin-6 receptor antagonist, is approved for the treatment of CRS. […] TCZ is likely a safe and effective modality of treatment for improving clinical and laboratory parameters of SARS CoV-2 patients with a reduction in ICU stay and ventilatory care need. | 2020-07-29 |
| 32719281 | Hence, the Association of Radiation Oncologists of India has come up with an advisory for radiation therapy keeping in mind such aspects. | 2020-07-29 |
| 32719655 | Sixty-seven PwE (18%) reported seizure worsening, which was best explained by the number of anti-seizure medications (ASM) of chronic therapy and the severity of sleep disorder. | 2020-07-29 |
| 32719683 | COVID-19 is a disease characterized by a strong inflammatory response in severe cases, which fails to respond to corticosteroid therapy. | 2020-07-29 |
| 32719731 | Since SARS-CoV2 was declared a Public Health Emergency of International Concern, those tasked with the stewardship of public health at a global, regional, and local level-policymakers, politicians, scientists, drug regulators, health officials, professional associations, journal editors, publishers, and clinicians-have displayed rushed decisions and lapses in judgment in their handling of chloroquine and hydroxychloroquine as potential COVID-19 therapeutics and prophylactics. | 2020-07-29 |
| 32719737 | The Coronavirus (2019-Cov-2) infection Covid-19 is highly contagious caused by single stranded RNA virus (+ssRNA) with nucleocapsid and spreading widely all across the world and responsible for more than 3.6 million morbidity and 0.25 million mortality No specific treatment is available till date. […] The genetic composition of Corona Virus (SARS-CoV) is almost similar to Covid-19, thus indicates good chances of effectiveness or enhancement in results by Nitric Oxide along with other modes in treatment of Covid-19. | 2020-07-29 |
| 32719749 | Patients with cancer, and particularly hematologic malignancies may be at higher risk for severe complications due to their malignancy, immune dysregulation, therapy, and associated comorbidities. | 2020-07-29 |
| 32719750 | Results: A combination regimen of antiviral therapy and high-dose intravenous immunoglobulin (IVIG) in the early stage seemed to be effective for treating CLL and SARS-Cov-2 infection. […] We need further studies to clarify suspending or continuing CLL therapy during COVID infection. | 2020-07-29 |
| 32719766 | The median time from illness onset to corticosteroid treatment was 9 days (IQR, 7-10). […] The median duration and accumulated dose of corticosteroid treatment were 4.5 days [interquartile range (IQR), 3-5] and 140 mg of methylprednisolone (IQR, 120-200). […] With the corticosteroid treatment, all patients achieved an abatement of fever within 1 day, and 78.6% (22/28) of the patients achieved radiological remission when evaluated about 3 days later. […] When adjusted for age, sex, underlying comorbidities, baseline blood laboratory parameters, viral load, and chest radiological findings, the causal hazard ratio of corticosteroid treatment for the viral clearance was 0.79 (95%CI, 0.48-1.30, p = 0.34). | 2020-07-29 |
| 32719767 | However, the current rapid and exponential rise in the number of patients has necessitated efficient and quick prediction of the possible outcome of an infected patient for appropriate treatment using AI techniques. | 2020-07-29 |
| 32719799 | Research on synthetic drugs and vaccines has become a focus of attention in China and other countries, as such approaches are regarded as key tools for disease prevention and control; however, the development of these therapeutics will take months, or even years. […] Under such circumstances, development of coronavirus specific therapeutics is urgent. | 2020-07-29 |
| 32719806 | Demographic, clinical characteristics, comorbidities, and chest computed tomography (CT) image, mental state, medication status, and nucleic acid test data were summarized and analyzed. | 2020-07-29 |
| 32719848 | Among patients with CAPA receiving voriconazole treatment (13 patients, 43%) A trend toward lower mortality (46% vs 59% p=0.30) and reduction of galactomannan index in consecutive samples was observed. | 2020-07-29 |
| 32719932 | Appropriate adjustments of trauma bay protocols during pandemics should improve safety for both patients and medical personnel while guaranteeing the optimal treatment quality. | 2020-07-29 |
| 32720082 | Guideline-directed medical therapy for heart failure should not be interrupted for theoretical concerns but rather based on tolerance and clinical presentation. | 2020-07-29 |
| 32720233 | It is currently unknown whether concomitant SARS-CoV-2 infection and GBS are pathophysiologically related, what biomarkers are useful for diagnosis, and what is the optimal treatment given the medical comorbidities, complications, and simultaneous infection. | 2020-07-29 |
| 32720256 | We found that moist mask heating (65-80°C at 50-85% relative humidity for 20-30 min) and vaporous hydrogen peroxide treatment were supported by the literature to provide consistent viral decontamination without compromising mask seal and filtration efficiency. | 2020-07-29 |
| 32720259 | Age, sex, comorbidities, rheumatic disease diagnosis and treatment, disease activity prior to infection, radiographic and laboratorial results at arrival were analysed. […] No differences in sex, radiological abnormalities, rheumatological disease, background therapy or symptoms before admission between deceased patients and survivors were found. […] Our results suggest that comorbidities, rheumatic disease activity and laboratorial abnormalities such as C-reactive protein (CRP), D-Dimer, lactate dehydrogenase (LDH), serum ferritin elevation significantly associated with mortality whereas previous use of rheumatic medication did not. | 2020-07-29 |
| 32720298 | In the face of a pandemic or similar emergencies, communities of people who use drugs face risks that result from their ongoing drug use, reduced ability to secure treatment for drug use and correlated maladies, lack of access to preventive hygiene, and the realities of homelessness, street-level policing, and criminal justice involvement. […] This coalition identified the communities at risk: active users needing access to harm reduction services, persons in treatment needing access to their medications, the homeless and marginally housed needing improved hygiene, people engaged in sex work, and the incarcerated needing release from custody. | 2020-07-29 |
| 32720374 | The impact of the COVID-19 pandemic on the treatment of patient with aortic valve stenosis is unknown and there is uncertainty on the optimal strategies in managing these patients. | 2020-07-29 |
| 32720399 | Participants in the United States (US, N = 511) and the Netherlands (NL, N = 510), recruited through ongoing studies and social media, completed an online survey that included both quantitative measures and free-text responses assessing the impact of COVID-19 on situational circumstances, eating disorder symptoms, eating disorder treatment, and general well-being. […] Although many participants acknowledged and appreciated the transition to telehealth, limitations of this treatment modality for this population were raised. | 2020-07-29 |
| 32720520 | The coronavirus disease 2019 (COVID-19) pandemic laid bare the immediate need for primary palliative care education for many clinicians. […] This article describes the design and dissemination of palliative care education for primary care clinicians using an established curriculum development method. […] To develop a succinct and practical palliative care toolkit for use by primary care clinicians during the COVID-19 pandemic, focused on 2 key elements: (i) advance care planning communication skills based on the narrative 3-Act Model and (ii) comfort care symptom management at the end of life. […] The toolkit was finalized through an iterative process involving a team of end-users and experts in palliative care and primary care, including social work, pharmacy, nursing, and medicine. […] While we had been focused primarily on the inpatient setting, our palliative care team at Johns Hopkins Bayview Medical Center pivoted existing infrastructure and curriculum development expertise to meet the expressed needs of our primary care colleagues during the COVID-19 pandemic. […] Through collaboration with an interprofessional team including end-users, we designed and disseminated a concise palliative care toolkit within 6 weeks. | 2020-07-29 |
| 32720577 | Overall, our results suggest that EGCG, TF2a, TF2b, TF3 can inhibit RdRp and represent an effective therapy for COVID-19. | 2020-07-29 |
| 32720578 | The targeted therapeutics of small molecules helps the scientific community to fight against SARS-CoV-2. […] Compound A38 has the highest G-score (-7.83) when compared to all the standard compounds which are proposed for COVID-19 treatment such as ritonavir (-7.48), lopinavir (-6.94), nelfinavir (-5.93), hydroxychloroquine (-5.47) and mataquine (-5.37). | 2020-07-29 |
| 32720605 | No FDA approved vaccine or antiviral is available for the treatment of this infection. | 2020-07-29 |
| 32720611 | This article discusses relevant aspects in the treatment of patients with COVID-19. […] Recommendations are provided for outpatient and inpatient antithrombotic therapy for patients with COVID-19. | 2020-07-29 |
| 32720612 | Since there is no specific therapy for this new coronavirus infection (COVID-19), searching for an effective and safe anti-inflammatory therapy is critical.Materials and methods This study evaluated efficacy and safety of pulse therapy with high doses of glucocorticosteroids (GCS), methylprednisolone 1,000 mg for 3 days plus dexamethasone 8 mg for another 3-5 days, in 17 patients with severe coronavirus pneumonia as a part of retrospective comparative analysis (17 patients in control group). […] Patients had signs of lung injury (53.2 % and 25.6 %), increases in CRP 27 and 19 times, and a more than doubled level of D-dimer (to 1.41 µg/ml and 1.15 µg/ml) in the active therapy and the control groups, respectively. […] The GCS treatment group had a more severe condition at baseline.Results The GCS pulse therapy proved effective and significantly decreased the CCS-COVID scores. […] The dynamics of lung injury by CT was better in the treatment group but the difference did not reach a statistical significance (р=0.062). […] Following the GCS treatment, neutrophilia increased (р=0.0001) with persisting lymphopenia, and the neutrophil/lymphocyte (N/L) ratio, a marker of chronic inflammation, increased 2.5 times (р=0.006). […] The changes in the N/L ratio and D-dimer were found to correlate in the GCS pulse therapy group (r =0.49, p=0.04), which underlined the relationship of chronic autoimmune inflammation with thrombus formation in COVID-19. […] In result, four patients developed venous thromboembolic complications (two of them had pulmonary artery thromboembolism) after the GCS pulse therapy despite the concomitant antiplatelet treatment at therapeutic doses. […] Recovery was slower in the hormone treatment group (median stay in the hospital was 26 days vs 18 days in the control group, р=0.001). […] Conclusion Pulse therapy with high doses of GCS exerted a rapid anti-inflammatory effect but at the same time, increased the N/L ratio and the D-dimer level, which increased the risk of thromboembolism. | 2020-07-29 |
| 32720702 | Since cytokine release syndrome with elevation of interleukin-6 (IL-6) is considered to be associated with severe cases of coronavirus disease 2019 (COVID-19); IL-6 inhibitors, such as tocilizumab, are expected to be effective for its treatment. | 2020-07-29 |
| 32720761 | However, the prognosis may depend on the cancer stage and the type of treatment administered. […] In cases of patients with active infection, the recommendation is to hold treatment until recovery. […] For other patients, due to the aggressive nature of lung cancer, the guidelines suggest not to delay curative treatments in non-metastatic disease and provide palliative treatment in shortened protocols. | 2020-07-29 |
| 32720827 | Heparin-induced thrombocytopenia (HIT) is a well-known complication of heparin therapy. | 2020-07-29 |
| 32720978 | Pathogenesis of SARS-CoV-2 infection presents significant similarities to those of some immune-mediated diseases, such as inflammatory bowel diseases or rheumatoid arthritis, leading to the hypothesis that targeted therapies used for the treatment of immune-mediated disease could be effective to treat (and possibly prevent) the main complications of COVID-19. | 2020-07-29 |
| 32721015 | The COVID-19 pandemic has disrupted healthcare, with its far-reaching effects seeping into chronic disease evaluation and treatment. […] Pre-pandemic, we were able to ensure rapid treatment via validated protocols delivered by a co-localized multidisciplinary team within the hospital setting. | 2020-07-29 |
| 32721038 | After a series of treatment, 176 and 1169 were stable and alive in groups A and B, respectively. | 2020-07-29 |
| 32721206 | This document summarizes the experience of the International Uveitis Study Group (IUSG), the Intraocular Inflammation Society (IOIS), and the Foster Ocular Inflammation Society (FOIS) and can aid as a guide for the treatment of uveitis patients in the era of COVID-19 pandemic. | 2020-07-30 |
| 32721449 | Some strategies adopted by China where existing antiviral therapy was initially used to treat COVID-19 have not given very successful results. […] In some cases, combination therapy of antiviral drugs with chloroquine showed better action against COVID-19. […] In Israel as well as in other developed countries, pluristems allogeneic placental expanded cell therapy has been found successful. | 2020-07-30 |
| 32721500 | The national Swedish Register of Palliative Care was used. | 2020-07-30 |
| 32721528 | IL6ri were initially reserved for critically ill patients, but after review, treatment was liberalized to patients with lower oxygen requirements. | 2020-07-30 |
| 32721534 | Adsorptive granulocyte and monocyte apheresis (GMA), used for ulcerative colitis, is an extracorporeal therapy designed to remove activated myeloid lineage cells. […] The modes of action of GMA together with the findings of this case report indicate that GMA could be a relevant treatment option for COVID-19. | 2020-07-30 |
| 32721580 | Recently, the Food and Drug Agency (FDA) and the European Medicines Agency (EMA) recommended remdesivir for the treatment of patients hospitalized with severe coronavirus disease 2019 (COVID-19) infection.1,2 In the remdesivir clinical development program, some cases have raised concerns regarding potential hepatobiliary disorders associated with remdesivir, including in healthy volunteers and patients with COVID-19.3 In cohort studies of patients hospitalized for severe COVID-19 who were treated with compassionate-use remdesivir, elevated hepatic enzymes were the most frequent adverse drug reaction reported.4,5 In the first randomized, double-blind, placebo-controlled clinical trial assessing the effect of intravenous remdesivir in adults admitted to hospital with severe COVID-19 (n = 237), a higher proportion of remdesivir recipients than placebo recipients had dosing prematurely stopped by the investigators because of adverse events including aminotransferase or bilirubin increases (3 versus 0).6 Although there is no signal from the available data of severe hepatotoxicity or drug-induced liver injury in clinical trials, the number of patients exposed to remdesivir was too limited. | 2020-07-30 |
| 32721813 | Utilising biomarkers for COVID-19 diagnosis, prediction of treatment response and overall prognostication have been investigated recently. | 2020-07-30 |
| 32721958 | This pandemic has caused disruption in communities and hospital services, as well as straining blood product supply, affecting chemotherapy treatment and haematopoietic stem cell transplantation schedule. | 2020-07-30 |
| 32722014 | The economic and health crisis created by the COVID-19 pandemic as well as the public health measures currently taken to stop the spread of the virus may have an impact on household TB transmission, treatment and diagnostic services, and TB prevention and control programs. | 2020-07-30 |
| 32722574 | The clinical treatment of the severe acute respiratory syndrome (SARS) CoV-2 is currently based on the experimental administration of HIV antiviral drugs, such as lopinavir, ritonavir, and remdesivir (a nucleotide analogue used for Ebola infection). | 2020-07-30 |
| 32722596 | While the main treatment of the COVID-19 intoxication is focused on neutralizing the excessive inflammatory response, it is worth considering an equally significant problem of the immunosuppressive conditions including immuno-paralysis, which lead to the secondary infection. […] Therefore, choosing a treatment strategy for the immune-mediated complications of coronavirus infection, one has to pass between Scylla and Charybdis, so that, in the fight against the “cytokine storm,” it is vital not to miss the point of the immune silence that turns into immuno-paralysis. | 2020-07-30 |
| 32722697 | This approach may prove useful to stage lung disease severity, prognosticate, and predict treatment response and survival, thereby informing risk management and resource allocation. | 2020-07-30 |
| 32722924 | With no effective treatment or vaccine, prolonged mechanical ventilation is common in survivors. | 2020-07-30 |
| 32722927 | Therefore, anticoagulation and anti-inflammatory therapy can be used as important treatment strategies for severe COVID-19. | 2020-07-30 |
| 32722946 | The study of common pathogenetic mechanisms, such as the involvement of toll-like receptor 4, could contribute to the knowledge and treatment of idiopathic and RA-ILD. | 2020-07-30 |
| 32722980 | The clinical features of patients include epidemiology, clinical symptoms, laboratory and imaging test, treatment and prognosis. | 2020-07-30 |
| 32722990 | Early detection and treatment for these presymptomatic patients before symptom onset can shorten the communicable period for the coronavirus and reduce the occurrence of severe cases. | 2020-07-30 |
| 32723104 | Nonsteroidal anti-inflammatory drugs (NSAIDs) have been an important therapy in the treatment of a large number of cutaneous pathologies for more than three decades. | 2020-07-30 |
| 32723108 | Long term immunosuppressive treatment may be required to minimize the consequences of the disease. | 2020-07-30 |
| 32723142 | Due to the lack of specific treatment against SARS-CoV-2, effective vaccines and antiviral agents are urgently needed to properly restrain the COVID-19 pandemic. […] This review discusses the potential therapeutic approaches, in addition to the contribution of nanomedicine against CoVs in the fields of vaccination, diagnosis and therapy. | 2020-07-30 |
| 32723229 | There is still not any proved exact treatment of COVID-19 with high level of evidence. | 2020-07-30 |
| 32723442 | This systematic review discusses epidemiology, pathogenesis, transmission, clinical manifestations, severity, treatment, prevention, vaccination, medication repositioning, potential drug candidates, and control and public awareness of COVID-19. | 2020-07-30 |
| 32723443 | Key Words: Acute kidney injury, Angiotensin-converting enzyme, Sepsis, Cytokine storm, Kidney replacement therapy, Coronavirus disease 2019. | 2020-07-30 |
| 32723554 | In this document, we suggest recommendations as to how to triage patients diagnosed with ACSs and provide with algorithms of how to manage the patients and decide the appropriate treatment options in the era of COVID-19 pandemic. | 2020-07-30 |
| 32723601 | Tocilizumab, a monoclonal antiinterluekin-6 receptor antibody, has been empirically used in the treatment of cytokine release syndrome associated with severe coronavirus disease 2019 infections. […] This case report analyzes the risks of acute large bowel perforation after using this medication empirically and discusses the appropriate management of this adverse event. | 2020-07-30 |
| 32723622 | Its correct treatment helps to improve the control of the same and the correct use of the resources available at the moment. | 2020-07-30 |
| 32723801 | The search for a suitable vaccine as well as effective therapeutics for the treatment of COVID-19 is underway. […] Drug repurposing screens provide a useful and effective solution for identifying potential therapeutics against SARS-CoV-2. […] For example, the experimental drug remdesivir, originally developed for Ebola virus infections, has been approved by the US Food and Drug Administration as an emergency use treatment of COVID-19. […] In this review, we discuss recent findings on the pathology of coronaviruses and the drug targets for the treatment of COVID-19. […] A multitarget treatment approach with synergistic drug combinations containing different mechanisms of action may be a practical therapeutic strategy for the treatment of severe COVID-19. […] SIGNIFICANCE STATEMENT: Understanding the biology and pathology of RNA viruses is critical to accomplish the challenging task of developing vaccines and therapeutics against SARS-CoV-2. […] This review highlights the anti-SARS-CoV-2 drug targets and therapeutic development strategies for COVID-19 treatment. | 2020-07-30 |
| 32724028 | He tested positive for SARS-CoV-2, and was treated with hydroxychloroquine, azithromycin and ceftriaxone, and was discharged home after five days of inpatient treatment. | 2020-07-30 |
| 32724296 | Therefore, blocking these molecules might be useful in COVID-19 treatment and should be further studied in the context of targeted therapy. | 2020-07-30 |
| 32724668 | In this study, we describe our experience regarding the necessary protective measures that need to be taken during ophthalmic examination and treatment. | 2020-07-30 |
| 32724831 | Here we review the cellular pathophysiology, clinical manifestations and treatment modalities of the cardiac manifestations seen in patients with COVID-19. | 2020-07-30 |
| 32724866 | Given the high case fatality rate of SARS-CoV-2, for which there is no cure and no vaccine, clinicians are forced to make decisions about how best to manage patients with limited high-quality evidence to guide treatment. | 2020-07-30 |
| 32725059 | By using ultracentrifugation method associated to quantitative reverse transcription polymerase chain reaction (RT-qPCR) we detected SARS-CoV-2 in 41.6% (5/12) of raw sewage samples obtained from sewage treatment plants and sewers network in the city. | 2020-07-30 |
| 32725209 | It includes an emergency room doctor, a supervisor from the medical regulation centre (Centre 15), an infectious disease physician, a medical hygienist and a palliative care specialist.To organise an ad hoc follow-up channel, including the necessary resources for the different levels of care required, according to the resources of the territorial network, and the creation of a specific COVID geriatric palliative care service. | 2020-07-30 |
| 32725286 | The current outbreak of pandemic coronavirus disease 2019 (COVID-19) aggravates serious need for effective therapeutics. | 2020-07-30 |
| 32725351 | A large number of reports have explained the clinical characteristics and treatment strategies of COVID-19, but the characteristics and treatment of COVID-19 patient with systemic lupus erythematosus (SLE) are still unclear. […] Here, we report the clinical features and treatment of the first SLE patient with confirmed COVID-19 pneumonia. […] She continued to take the previous SLE drugs (doses of glucocorticoids, hydroxychloroquine, and immunosuppressive agents were not reduced) and was treated with strict antiviral and infection prevention treatment. […] After the first discharge, she got a recurrence of COVID-19 during her home isolation, and then returned to hospital and continued the previous therapy. […] The successful recovery of this case has significant reference value for the future treatment of COVID-19 patients with SLE. […] Key Points • COVID-19 patients with SLE is advocated to continue the medical treatment for SLE. | 2020-07-30 |
| 32725382 | Any therapy should be used with caution in the light of potential drug interactions and the uncertainty of optimal doses for treating mild versus serious infections. | 2020-07-30 |
| 32725501 | Verified areas of care include treatment of chronic conditions, topical skin cancer therapy, wound monitoring, and post-procedural follow-up. | 2020-07-30 |
| 32725744 | After symptomatic support treatment, in both the patients, renal function was obviously restored, and both recovered from this pneumonia and conformed to the discharge criteria. | 2020-07-30 |
| 32725762 | Data on clinical and demographic features, maintenance treatment, disease course, and outcomes in individuals with IA (rheumatoid arthritis and spondyloarthritis) with symptomatic COVID-19 infection were prospectively assessed via web-based questionnaire followed by individual phone calls and electronic medical record review. […] Baseline characteristics and medication use were summarized for hospitalized and ambulatory patients, and outcomes with the different medication classes were compared using multivariable logistic regression. […] Among patients with underlying IA, COVID-19 outcomes were worse in those receiving glucocorticoids but not in patients receiving maintenance anticytokine therapy. | 2020-07-30 |
| 32725858 | During coronavirus disease 2019 (COVID-19) epidemic, reducing the number of invasive procedure and choosing conservative medication strategy for patients with non-ST-segment elevation myocardial infarction (NSTEMI) is unavoidable. | 2020-07-30 |
| 32725884 | Understanding the epidemiological characteristics, clinical characteristics, and diagnosis and treatment of the first patients in various countries are of great significance for the identification, prevention and control of COVID-19. | 2020-07-30 |
| 32725890 | Medications used in COVID-19 treatment (lopinavir/ritonavir, hydroxychloroquine, remdesivir, and tocilizumab) were associated with peak hospitalization liver transaminase elevations >5x ULN. | 2020-07-30 |
| 32725927 | This phenotype could be partially rescued by treatment with the AngII type 1 receptor (AT1R) antagonist, losartan, suggesting that the observed effect was mediated by AngII acting on its main receptor. […] Thus the Ace2-/- cornea, because of easy accessibility, may provide an attractive model to explore the molecular mechanisms, immunological changes, and treatment modalities in patients with COVID-19. | 2020-07-30 |
| 32726003 | The study found that with the intake of medication, the incidence rate of TCM intervention group was basically maintained at a low and continuous stable level(0.01%-0.02%), while the non-intervention group showed an overall trend of continuous growth(0.02%-0.18%) from 3 to 14 days. | 2020-07-30 |
| 32726004 | Traditional Chinese medicine(TCM) has both systematism theory knowledge and clinical practical value in the prevention and treatment of COVID-19. […] Therefore, it was particularly important to examine the effect of TCM in the prevention and treatment of COVID-19. […] We aimed to provide reference for the prevention and treatment of COVID-19 by extracting and analyzing the TCM patents from the Patent Information Sharing Platform of COVID-19. […] There were total 292 TCM patents, including 52 patents for etiological treatment and 240 patents for symptomatic treatment. […] The patents for treatment of coronavirus mainly focused on the treatment of coronavirus, while the patents for symptomatic treatment mainly focuses on the improvement of respiratory symptoms, such as fever and cough. […] The analyzed results of the TCM patents from the patent information sharing platform of COVID-19 were consistent with the Guideline of Diagnosis and Treatment of COVID-19(7th edition), and the combination of TCM in each cluster may also provide future directions for drug compatibility. | 2020-07-30 |
| 32726005 | It is of great significance to discuss the rules and characteristics of the prescription of traditional Chinese medicine in the treatment of COVID-19. […] From the analysis of high-frequency drugs to the core combinations, one can see that the main treatment principle for severe COVID-19 is to remove internal and external dampness, protect the spleen and stomach, remove evil energy, and support righteousness. | 2020-07-30 |
| 32726006 | Based on the second edition and the third edition of COVID-19 Mongolian Medicine Prevention and Treatment Guidance Program issued by the Inner Mongolia Autonomous Region Health Commission, using Excel 2007, SPSS Modeler 18, SPSS Statistics 25, Cytoscape 3.7.1 statistical software as a tool, the association rules analysis and cluster analysis of Mongolian medicine included in the standard were carried out. […] The main drugs for the prevention of COVID-19 were Liang(13 times, 38.23%), Wen(9 times, 26.47%), the flavor was Ku(20 times, 34.48%), Xin(13 times, 22.41%), Gan(11 times, 18.97%), the most used drugs treating hot evil(99 times, 32.46%), treatment of “Heyi” drugs(51 times, 16.72%), treatment of “Badagan” drugs(40 times, 13.11%), treatment of “sticky” drugs(37 times, 12.13%), and a cough, eliminating phlegm and antiasthmatic(31 times, 10.16%), the association rule analysis found that the highest association intensity of the drug pair combination of 11. […] In this study, 45 prescriptions of Mongolian medicine for the prevention of COVID-19 were collec-ted and further analyzed, hoping to provide new ideas for clinical diagnosis and treatment. | 2020-07-30 |
| 32726007 | The model can simulate the traditional Chinese medicine treatment of common disease syndromes in Coronavirus Disease 2019 Diagnosis and Treatment Program(the sixth edition for trial). | 2020-07-30 |
| 32726008 | This study analyzed the application of classic prescriptions in the diagnosis and treatment schemes based on the Diagnosis and Treatment Schemes for Coronavirus Disease at the country, provincial and municipal levels, and further explored its disrobing effect on COVID-19 disease severe phase network, and selected representative prescriptions for core target screening and gene enrichment analysis, so as to reveal its mechanism of action. | 2020-07-30 |
| 32726134 | The thrombus was partially or completely absorbed after anticoagulant therapy in 3 patients who underwent a follow-up CTPA. | 2020-07-30 |
| 32726206 | Extracorporeal membrane oxygenation (ECMO) treatment can provide patients with cardiopulmonary function support and buy time for clinicians’ treatment. […] However, some patients still suffer from poor oxygenation after ECMO treatment. […] It is a great challenge for COVID-19 patients to change their postures while receiving ECMO treatment. | 2020-07-30 |
| 32726217 | According to the published data, we summarize the myocardial injury manifestations, characteristics, effects on disease condition, and prognosis of 2019-nCoV-infected patients and discuss the possible injury mechanism, treatment methods, and future research directions. | 2020-07-30 |
| 32726230 | Given that there is neither a vaccine nor proven treatment for COVID-19, there is currently an urgent need for effective pharmacotherapy. […] To address the need for an effective treatment of SARS-CoV-2 during the worldwide pandemic, this systematic review of intravenous (IV) remdesivir was performed. […] Therefore, despite supportive data from in vitro and in vivo studies, the clinical effectiveness of IV remdesivir for treatment of COVID-19 and potential side effects remain incompletely defined in the human population. | 2020-07-30 |
| 32726238 | Here, we present a brief overview of the pharmacology of chloroquine and hydroxychloroquine, manifestations of toxicity, and treatment considerations. | 2020-07-30 |
| 32726244 | Early detection and treatment of agitation, precautions to minimize staff hazards, coordination with security personnel and psychiatric services, and avoidance of coercive strategies that cause respiratory depression will help mitigate heightened risks to safety caused by this outbreak. | 2020-07-30 |
| 32726355 | Although IFN treatment gave some encouraging results against SARS-CoV and MERS-CoV in animal models, its potential as a therapeutic against COVID-19 awaits validation. […] While awaiting the results of the many clinical trials that are evaluating the efficacy of IFN-I alone or in combination with antiviral molecules, we discuss the potential benefits of a well-timed IFN-I treatment and propose strategies to boost pDC-mediated IFN responses during the early stages of viral infection. | 2020-07-30 |
| 32726361 | There are no drugs or other therapeutics approved by the US Food and Drug Administration to prevent or treat COVID-19: information on the disease is very limited and scattered even if it exists. | 2020-07-30 |
| 32726441 | Winter CARVs were dominant during the early SARS-CoV-2 pandemic, impacting infection control and treatment decisions, but were rapidly replaced, suggesting competitive infection. | 2020-07-30 |
| 32726515 | Approximately one-fifth of the participants had no idea about treatment and immunisation against COVID-19. | 2020-07-30 |
| 32726561 | A majority of centers curtailed diagnostic testing and a minority limited new starts of medical therapy. […] While the total number of patients with PAH/CTEPH recognized to have COVID-19 was small, the impact of COVID-19 on broader clinic operations, testing, and treatment was substantial. | 2020-07-30 |
| 32726724 | This study aimed to describe the effectiveness and optimum use of tocilizumab (TCZ) treatment by the support of clinical, laboratory and radiologic observations. | 2020-07-30 |
| 32726792 | This study summarizes a single-centre experience, during the COVID-19 period in Italy, in the treatment of brain metastases with Gamma Knife stereotactic radiosurgery (GKRS). | 2020-07-30 |
| 32726868 | With respect to the treatment of the acute phase, therapy with steroids was associated with the adverse composite endpoint (OR = 3.61, 95% CI 1.934-6.73), but not with mortality. | 2020-07-30 |
| 32727050 | Yet, there is no specific vaccine or treatment for this COVID-19 where anti-disease measures rely on preventing or slowing the transmission of infection from one person to another. | 2020-07-31 |
| 32727101 | During the spread of epidemics, restricting the range of activities of personnel is one of the options for the prevention and treatment of infectious diseases. | 2020-07-31 |
| 32727107 | Treatment of acute respiratory distress syndrome (ARDS) due to COVID-19 pneumonia (CARDS) represents a clinical challenge, requiring often invasive mechanical ventilation (IMV). […] Despite treatment with antiviral and non-invasive ventilation (NIV), after 24 h there was a progressive worsening of clinical conditions with higher fever (40 °C), increased dyspnea, and hypoxia (PaO2/FiO2 or P/F ratio of 150). | 2020-07-31 |
| 32727145 | These PDE inhibitors have already been used in the treatment of pathologies that show clinical signs and symptoms completely or partially overlapping with post-COVID-19 conditions (e.g., thrombosis, inflammation, fibrosis), while new PDE-selective or pan-selective inhibitors are currently under study. […] This review discusses the state of the art of the different pathologies currently treated with phosphodiesterase inhibitors, highlighting the numerous similarities with the disorders linked to SARS-CoV2 infection, to support the hypothesis that PDE inhibitors, alone or in combination with other drugs, could be beneficial for the treatment of COVID-19. | 2020-07-31 |
| 32727177 | The patients were divided into the death group (n=40) and the survival group (n=24) according to the treatment outcomes. […] Early prevention of myocardial injury and treatment of acute viral myocarditis complicated with disease progression may provide insights into treatment and reduction of mortality in patients with severe COVID-19. | 2020-07-31 |
| 32727305 | Clinical characteristics, reperfusion therapy modalities, COVID-19 status and in-hospital mortality of consecutive STEMI patients who were admitted to Belgian hospitals for percutaneous coronary intervention (PCI) were recorded during a three-week period starting at the beginning of the lockdown period on 13 March 2020. […] However, there was a significant delay in treatment during the lockdown period, with more late presentations (>12 h after onset of pain) (14% versus 7.6%, p = .04) and with longer door-to-balloon times (median of 45 versus 39 min, p = .02). […] The present study revealed a 26% reduction in STEMI admissions and a delay in treatment of STEMI patients. | 2020-07-31 |
| 32727456 | The median COVID-19 treatment duration and hospital stay were 14.0 and 18.0 days, respectively. […] The length of hospital-stay and antiviral treatment duration for COVID-19 were slightly longer than those in Wuhan. | 2020-07-31 |
| 32727467 | Relatively little attention has been paid to understanding how the pandemic has affected treatment, prevention and control of malaria, which is a major cause of death and disease and predominantly affects people in less well-resourced settings. […] For detection and treatment of malaria, individuals may stop attending health facilities, out of fear of exposure to COVID-19, or because they cannot afford transport, and health care workers require additional resources to protect themselves from COVID-19. | 2020-07-31 |
| 32727485 | Meanwhile, pathogenesis, cardiovascular disease in COVID-19 patients, myocardial injury and venous thromboembolism induced by SARS-CoV-2 as well as the treatment methods are summarized in this review. | 2020-07-31 |
| 32727583 | The majority of head and neck surgical oncology from initial diagnosis and work up to surgical treatment and then follow-up involves aerosol generating medical procedures (AGMPs) which inherently put head and neck surgeons and practitioners at high risk for transmission of COVID19. […] The aggressive nature of the majority of head and neck cancer negates the ability for deferring surgical treatment for a prolonged period of time. […] Enhanced triaging including aggressive pre-treatment COVID19 testing should be used to identify patients with high risk of COVID19 transmission. | 2020-07-31 |
| 32727613 | Participants with any of the following conditions are excluded: pregnancy, breastfeeding, ongoing antiviral, antiretroviral or corticosteroids treatment, chloroquine or hydroxychloroquine uptake the last month or any contraindication to hydroxychloroquine treatment. […] Eligible participants will be allocated to one of the two study groups: Intervention group (PrEP): participants will receive the standard of care and will take 400mg of hydroxychloroquine (2 tablets of 200 mg per Dolquine® tablet) daily the first four consecutive days, followed by 400 mg weekly for a period of 6 months. participants will receive placebo tablets with identical physical appearance to hydroxychloroquine 200 mg (Dolquine®) tablets following the same treatment schedule of the intervention group. […] As secondary endpoints, we will obtain: i) the SARS-CoV-2 seroconversion in the PrEP group compared to placebo during the 6 months of follow-up in healthcare workers with negative serology at day 0; ii) the occurrence of any adverse event related with hydroxychloroquine treatment; iii) the incidence of SARS-CoV-2 infection and COVID-19 among healthcare workers in the non-PrEP group, among the total of healthcare workers included in the non-PrEP group during the study period; iv) the risk ratio for the different clinical, analytical and microbiological conditions to develop COVID-19; v) a repository of serum samples obtained from healthcare workers confirmed COVID-19 cases for future research on blood markers to predict SARS-CoV-2 infection. | 2020-07-31 |
| 32727624 | The trial objective is to determine if Continuous Positive Airway Pressure (CPAP) or High-Flow Nasal Oxygen (HFNO) is clinically effective compared to standard oxygen therapy in patients with confirmed or suspected COVID-19. […] 1) Planned tracheal intubation and mechanical ventilation imminent within 1 hour; 2) Known or clinically apparent pregnancy; 3) Any absolute contraindication to CPAP or HFNO; 4) Decision not to intubate due to ceiling of treatment or withdrawal of treatment anticipated; and 5) Equipment for both CPAP and HFNO not available. […] Set-up and therapy titration is not protocolised and is delivered in accordance with clinical discretion. […] Set-up and therapy titration is not protocolised and is delivered in accordance with clinical discretion. […] Set-up and therapy titration is not protocolised and is delivered in accordance with clinical discretion. | 2020-07-31 |
| 32727662 | Treatment in this subpopulation is complex due to the potential hepatotoxicity of some of the medicinal products used. […] Moreover, the pandemic has also negatively impacted patients with liver disease who have not contracted COVID-19, since the reallocation of human and material resources to the care of patients with the virus has resulted in a decrease in the treatment, diagnosis and follow-up of patients with liver disease, which will surely have negative consequences in the near future. | 2020-07-31 |
| 32727701 | We report a mild and attenuated SARS CoV-2 infection in a patient who is 17 months post stem cell transplantation and maintained on the JAK/STAT inhibitor ruxolitinib, a proposed novel therapy for SARS CoV-2 pneumonia. | 2020-07-31 |
| 32727811 | The coronavirus disease 2019 (COVID-19) pandemic placed unprecedented pressure on various healthcare systems, including departments that use immunotherapies such as chimeric antigen receptor (CAR) T-cell therapy and immunosuppression therapy in organ transplantation units. […] The true impact of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection on immunocompromised CAR T-cell therapy recipients and kidney transplant recipients (KTRs) has not yet been established. […] He received fully humanized, anti-B-cell maturation antigen, CAR T-cell therapy before 4 months and achieved strict complete remission. […] Viral clearance occurred together with the generation of specific anti-immunoglobulin G-SARS-CoV-2 antibodies after 2 weeks of treatment. […] We report a CAR T-cell therapy recipient diagnosed with COVID-19 for the first time. […] His virus clearance failure and life-threating cytokine storm during SARS-CoV-2 infection suggested that any decision to proceed CAR T-cell therapy during COVID-19 pandemics will require extensive discussion of potential risks and benefits. […] Immunosuppressant treatment based on ciclosporin could be relatively safe for KTRs diagnosed with COVID-19. | 2020-07-31 |
| 32727845 | Given its high specificity and affinity, we anticipate that these anti-CoV-2 antibodies will be useful as valuable reagents for accessing the antigenicity of vaccine candidates, as well as developing antibody-based therapeutics and diagnostics for CoV-2. | 2020-07-31 |
| 32728383 | The treatment of endometrial cancers remained the same although there was a marked shift from minimal access surgery to conventional surgery. | 2020-07-31 |
| 32728388 | Due to this situation, Zambia has not been able to import radioactive isotopes for High Dose Rate (HDR) brachytherapy, Iridium 192 (I192) and this has led to suspension of treatment for patients. […] Cancer of the cervix is the most common cancer in Zambia and brachytherapy is a core component of the treatment armamentarium. | 2020-07-31 |
| 32728419 | We therefore suggest that patients who develop COVID-19 should generally have their clozapine treatment continued. | 2020-07-31 |
| 32728438 | The level of interleukin-6 declined after treatment in five of six (83.3%) treatment group patients [compared to 15 of 28 (53.6%) in the control group] with a greater reduction in absolute IL-6 levels (P-value = 0.025). […] Treatment with COX-2 inhibitors was not associated with an increase in adverse outcomes. | 2020-07-31 |
| 32728444 | Gastrointestinal complications in critically ill patients during the COVID-19 pandemic pose a diagnostic and treatment dilemma. | 2020-07-31 |
| 32728473 | This has implications for the management of COVID-19-associated AKI and the resulting increased need for kidney replacement therapy (KRT) in the intensive care unit (ICU) and elsewhere in the hospital. […] (1) Nephrology programs should work with ICU programs to plan for the possibility that up to 30% or more of critically ill patients with COVID-19 admitted to ICU will require kidney replacement therapy (KRT). | 2020-07-31 |
| 32728768 | Medical decisions must always be based on the need and the treatment preferences of the individual patient. | 2020-07-31 |
| 32728769 | Medical decisions must always be based on the need and the treatment preferences of the individual patient. | 2020-07-31 |
| 32728817 | The differences from “classic” acute respiratory distress syndrome and the major effects these have on the treatment of COVID-19 are elucidated. […] With regard to treatment, supportive and intensive care approaches are discussed, including O2 administration and (non-)invasive ventilation. | 2020-07-31 |
| 32728926 | If a second wave occurs, a serious consideration should be given to ways of minimising the risk of contracting COVID-19 in these vulnerable patients either by using COVID-free facilities or delaying treatment until peak of infection has passed. | 2020-07-31 |
| 32728951 | Only one patient admitted for therapy has been identified as COVID-19 positive. | 2020-07-31 |
| 32728965 | This is a multicenter, prospective, observational study in consecutive, mechanically ventilated patients with ARDS (as defined by the Berlin criteria) affected with with COVID-19 (confirmed SARS-CoV-2 infection in nasal or pharyngeal swab specimens), admitted to a network of 36 Spanish and Andorran intensive care units (ICUs) between March 12 and June 1, 2020. | 2020-07-31 |
| 32729064 | Hence, it is the need of the hour to investigate the mechanisms which could better aid in the treatment of COVID-19-infected cardiovascular disease (CVD) patients. | 2020-07-31 |
| 32729110 | Treatment consisted in anticoagulation until removal of the central venous catheter and simple anti-aggregating medication on discharge. | 2020-07-31 |
| 32729111 | Mainly in the youngest stages, a new patient evaluated by telemedicine can be more difficult to diagnose and manage, and therefore some neuropaediatricians have chosen to carry out only follow-up visits, medication management and outcome reviews. | 2020-07-31 |
| 32729139 | To present the adaptations to treatment protocols made in a child and adolescent eating disorders (ED) unit during the eight-week confinement period mandated in response to the COVID-19 pandemic and examine clinical and treatment variables in the outpatient, day hospital, and inpatient care programs. […] Description of the implementation of a combined teletherapy program for outpatient and day-hospital patients and the adaptations made to the inpatient protocol. […] We held 1,329 (73.10%) telehealth consultations and 489 (26.9%) face-to-face outpatient visits with 365 patients undergoing treatment in the outpatient clinic or day hospital. […] Almost half of the children and adolescents studied experienced reactivation of ED symptoms despite treatment, and severe patients (25%) presented self-harm and suicide risk. […] The implementation of a combined teletherapy program has enabled continuity of care during confinement for children and adolescents with ED. […] Delivery of treatment to adolescents in the day hospital program posed the biggest challenge due to their greater degrees of severity and higher hospitalization rates. | 2020-07-31 |
| 32729142 | Only recent immunotherapy use (RR, 3.49; 95% CI, 1.08-11.27) was associated with death due to COVID-19 on multivariable analysis; chemotherapy treatment and recent major surgery were not predictive of COVID-19 severity or mortality. | 2020-07-31 |
| 32729288 | Overall, 60.0% of patients received antibiotic treatment and 66.0%, empirical antiviral treatment, mainly with lopinavir/ritonavir (65%) or hydroxychloroquine (42%). | 2020-07-31 |
| 32729363 | We have summarized and analyzed the clinical trial registration status and the latest research progress of eight major antiviral drugs during the epidemic of Coronavirus Disease 2019 (COVID-19), which can provide reference methods for clinical formulation of the best antiviral treatment. […] At present, no specific drug has been found for the treatment of COVID-19, the efficacy of antiviral drugs mostly comes from small sample studies or retrospective studies, and the level of clinical evidence is low. […] Besides, multi-drug combination therapy may become a more effective treatment choice, but the drug interactions and adverse drug reactions also need to be closely monitored. | 2020-07-31 |
| 32729367 | The aim of our present review is to furnish brief details about the statistics, diagnosis, epidemiology, pathogenesis, prevention and treatment of COVID-19 to assist researchers and the society at large to come to grip with the deadly disease.HighlightsCumbersome outbreak of the novel Coronavirus Disease 2019 (COVID-19) became a pandemicAt June 19, 2020, as per WHO report 8,618,787 infected cases and 457,275 dead were recorded globallyMajor spread was found to be human to human transmissionsPeople with positive COVID-19 were infected with severe respiratory syndromeMore animal and clinical studies have to be done to overcome this pandemic. | 2020-07-31 |
| 32729370 | However, no specific antiviral drugs or vaccines are immediately available for the treatment of this lethal disease. | 2020-07-31 |
| 32729392 | As of June 2020, there is no FDA approved antiviral therapy to eradicate this dreadful virus. | 2020-07-31 |
| 32729428 | Mesenchyma stem cells (MSCs) based treatment has the advantage of targeting numerous pathophysiological components of ARDS by secreting a series of cell factors, exerting anti-inflammatory, antioxidative, immunomodulatory, antiapoptotic, and proangiogenic effects, resulting in significant structural and functional recovery following ARDS in various preclinical models. […] And recently pilot clinical studies indicated MSCs based therapy was promise in treatment of ARDS caused by SARS-CoV-2. […] However, little is known about MSCs therapy for ARDS caused by COVID-19. | 2020-07-31 |
| 32729460 | He developed acute kidney injury requiring renal replacement therapy without reversibility, despite optimal treatment. | 2020-07-31 |
| 32729463 | Hence, the possibility of neurological damage caused by the virus demands immediate attention and investigation of the mechanisms involved, so as to customize the treatment of patients presenting with neurological complications. | 2020-07-31 |
| 32729494 | As knowledge regarding the dynamics and host-path interaction of COVID-19 causing Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) is currently unknown, the formulation of strategies concerning antiviral treatment, vaccination, and epidemiological control stands crucial. | 2020-07-31 |
| 32729620 | The patients belonging to this subset are most likely beyond the point where they could benefit from an antiviral therapy because most of their illness at this stage of disease is driven by inflammatory (over)response of the immune system. | 2020-07-31 |
| 32729633 | Whether antiaggregation therapy may play a role on fundoscopic-selected patients with COVID-19 requires prospective trials. | 2020-07-31 |
| 32729823 | Treatment of these critically ill patients is becoming one of the major challenges we are facing. […] Frequently, more than 10 types of drugs are used simultaneously in the treatment of these critically ill patients, and the combination of many different drugs may easily lead to drug interactions and adverse reactions. […] Therefore, clinical pharmacist should participate in the optimization of drug treatment programs. […] A case of a critically ill COVID-19 patient with respiratory failure and diabetes mellitus is used as an example of an analysis of the treatment plan, utilization of combined medications, and the delivery of pharmaceutical care. […] There were some drug use unreasonable phenomena, including the extended continuation of arbidol treatment, the use of broad-spectrum antibacterial drugs, the use of drugs with unproven anti-coronavirus effects. […] Clinical pharmacists should participate in the optimization of drug treatment programs and provide pharmaceutical care for critically ill COVID-19 patients; this can promote the rational use of drugs. | 2020-07-31 |
| 32729826 | The number of patients receiving their drugs from pharmacies was significantly higher in March 2020 than in March 2019, which is an indication of good therapy adherence. | 2020-07-31 |
| 32729939 | Thirty-two participants required treatment in intensive care unit (ICU group) and 68 were managed in hospital wards without needing ICU care (ward group). | 2020-07-31 |
| 32730095 | Along with the medicines, some countries are using convalescent plasma and mesenchymal stem cells for treatment. […] In this detailed review, we have discussed the structure of SARS-CoV-2, essential proteins, its lifecycle, transmission, symptoms, pathology, clinical features, diagnosis, prevention, treatment and epidemiology of the disease. | 2020-07-31 |
| 32730192 | COVID-19 may have an effect on HIV treatment outcomes and psychosocial health among older adults living with HIV. | 2020-07-31 |
| 32730199 | These services include telehealth with virtual and telephone medication therapy management sessions led by ambulatory care pharmacists and student pharmacists. | 2020-07-31 |
| 32730205 | This review analyzes the epidemiology, etiology, clinical characteristics, treatment and sequelae of the severe acute respiratory syndrome (SARS), the Middle East respiratory syndrome (MERS) and the 2019 novel coronavirus disease (COVID-19) to help provide direction for further studies that can help understand COVID-19. | 2020-07-31 |
| 32730214 | Tremendous efforts and resources have been invested in developing diagnosis, prognosis and treatment strategies to combat the disease. | 2020-07-31 |
| 32730233 | FUNDINGFinancial support for this project was provided by CHOP Frontiers Program Immune Dysregulation Team; National Institute of Allergy and Infectious Diseases; National Cancer Institute; the Leukemia and Lymphoma Society; Cookies for Kids Cancer; Alex’s Lemonade Stand Foundation for Childhood Cancer; Children’s Oncology Group; Stand UP 2 Cancer; Team Connor; the Kate Amato Foundations; Burroughs Wellcome Fund CAMS; the Clinical Immunology Society; the American Academy of Allergy, Asthma, and Immunology; and the Institute for Translational Medicine and Therapeutics. | 2020-07-31 |
| 32730234 | Benzodiazepines were given per treatment guidelines, abating the seizure activity. […] CONCLUSIONS For proper diagnosis and treatment, patients and clinicians should be aware that COVID-19 may not present in the typical fashion of respiratory distress and fever. | 2020-07-31 |
| 32730352 | We model the current scenario of closed schools and universities, social distancing of people above sixty years old and voluntary home quarantine to show that it is still not enough to protect the health system by explicitly computing the demand for hospital intensive care units. | 2020-07-31 |
| 32730589 | Given the absence of implemented therapies, new analysis, diagnosis, and therapeutics are of great importance. […] Applying protein structural prediction, we localized this PmRAW at the surface of the Spike protein, providing a potential targeted vector for diagnostics and therapeutics. | 2020-07-31 |
| 32730620 | We aimed to determine whether the COVID-19 pandemic changed patient response, hospital treatment and mortality from AMI. | 2020-07-31 |
| 32730678 | In this study, we aimed to evaluate the clinical findings, laboratory parameters, and prognosis of COVID-19 disease in end-stage renal patients undergoing hemodialysis treatment. […] We included the hemodialysis patients who have been diagnosed with COVID-19 disease and received inpatient treatment between 11 Match 2020 and 24 April 2020 in hospital. | 2020-07-31 |
| 32730781 | A detailed understanding of the role of metabolic regulation with respect to antiviral and inflammatory responses, together with knowledge of the strategies used by viruses to exploit immunometabolic pathways, will ultimately change our understanding and treatment of pathogenic viral diseases. | 2020-07-31 |
| 32730812 | During the coronavirus disease 2019 (COVID-19) pandemic, New York encountered shortages in continuous kidney replacement therapy (CKRT) capacity for critically ill patients with acute kidney injury stage 3 requiring dialysis. […] These findings, although based on limited data for CKRT demand and capacity, suggest there being value during health care crises such as the COVID-19 pandemic in establishing an inpatient kidney replacement therapy national registry and maintaining a national stockpile of CKRT equipment. | 2020-07-31 |
| 32730827 | Air and surface samples were collected from the isolation wards and intensive care units designated for coronavirus disease 2019 (COVID-19) patients. | 2020-07-31 |
| 32730830 | Two pandemic scenarios, early (risk mitigation) and late (severely reduced radiation therapy resources), were evaluated. […] The panel developed treatment recommendations for 5 HNC cases. […] There was agreement or strong agreement across a number of practice areas, including treatment prioritization, whether to delay initiation or interrupt radiation therapy for intercurrent SARS-CoV-2 infection, approaches to treatment (radiation dose-fractionation schedules and use of chemotherapy in each pandemic scenario), management of surgical cases in event of operating room closures, and recommended adjustments to outpatient clinic appointments and supportive care. | 2020-07-31 |
| 32730951 | The COVID-19 pandemic has highlighted the essential role of palliative care to support the delivery of compassionate, goal-concordant patient care. […] We created the Web-based application, PalliCOVID (https://pallicovid.app/), in April 2020 to provide all clinicians with convenient access to palliative care resources and support. […] PalliCOVID features evidence-based clinical guidelines, educational content, and institutional protocols related to palliative care for COVID-19 patients. […] It is a publicly available resource accessible from any mobile device or desktop computer that provides clinicians with access to palliative care guidance across a variety of care settings, including the emergency department, hospital ward, intensive care unit, and primary care practice. […] The primary objective of this study was to evaluate usage patterns of PalliCOVID to understand user behavior in relation to this palliative care content platform during the period of the local peak of COVID-19 infection in Massachusetts. […] PalliCOVID is one example of a scalable digital health solution that can bring palliative care resources to frontline clinicians. | 2020-07-31 |
| 32730975 | General demographics, clinical status, mechanism of trauma, diagnosis, and treatment instituted were recorded. | 2020-07-31 |
| 32731059 | Outcome was favorable in all cases despite immunosuppressive therapy, use of experimental COVID-19 medication and switching of plasma exchange for IVIG. | 2020-07-31 |
| 32731090 | Patients with ongoing or recent cancer treatment for advanced active disease, metastatic solid tumors and hematological malignancies are at higher risk of developing severe COVID-19 respiratory disease that requires hospitalization and have a poorer disease outcome compared to individuals without cancer. […] Surgery during the peak of the pandemic seems to increase mortality, but there is no convincing evidence that adjuvant systemic cancer therapy and radiotherapy are contraindicated, implicating that cancer treatment can be provided safely after individual risk/benefit assessment and some adaptive measures. | 2020-07-31 |
| 32731115 | The public has started to increasingly scrutinize the proper disposal and treatment of rapidly growing medical wastes, in particular, given the COVID-19 pandemic, raised awareness, and the advances in the health sector. | 2020-07-31 |
| 32731139 | During their treatment with hydroxychloroquine (HCQ), azithromycin and favipiravir, ventricular tachycardia episodes were observed in in two COVID-19 patients during their hospitalization in the intensive care unit. […] We believe that pre-treatment evaluation of repolarization parameters in newly diagnosed COVID-19 would be beneficial for predicting ventricular arrhythmia risk. | 2020-07-31 |
| 32731215 | Of 419 hospitalized patients with ESKD, 11 were on chronic PD therapy (2.6%). | 2020-07-31 |
| 32731277 | In analogy to the cytokine release syndrome (CRS) after CAR-T cell therapy, the therapeutic activity of the IL-6 receptor antibody tocilizumab is investigated in clinical studies.The coagulation system is activated during the inflammatory phase of COVID infection, most likely on the pathophysiological basis of immune thrombosis. […] Guidelines for the prophylaxis and therapy of COVID-associated coagulopathy have been developed. | 2020-07-31 |
| 32731279 | Many treatment modalities of COVID patients are “best practice”, but some aspects remain unclear at present. […] This article deals with diagnostics, monitoring and therapy with COVID-19 patients in intensive care units and with a suitable hygiene concepts.A hygiene concept is obligatory and must ensure - in addition to general measures - the training of employees and the hygienic discharge of material. […] After extubation, an intermittent NIV treatment for atelectase prophylaxis can be performed. | 2020-07-31 |
| 32731280 | Last, we review the current evidence on drugs which have been evaluated or are currently tested for the treatment of COVID-19 patients. | 2020-07-31 |
| 32731281 | Immunosuppressive therapy after kidney transplantation needs to be adapted upon diagnosis of COVID-19 depending on the severity of the initial presentation. | 2020-07-31 |
| 32731284 | Systematic follow-up, based on prudent pulmonary function testing, is warranted for the correct diagnosis, graduation and treatment of the underlying pathology at an early stage. | 2020-07-31 |
| 32731331 | Cyclosporine is an immunosuppressive drug, which is widely used in medicine, including in the treatment of autoimmune skin diseases in dermatology, rheumatology, ophthalmology and nephrology, and in organ transplantation. […] A usual concern associated with immunosuppressive treatment is the potential risk of infections. | 2020-08-01 |
| 32731360 | It may also lead to new therapeutic options for the treatment of thrombotic and cardiovascular disorders. | 2020-08-01 |
| 32731751 | At the end, 132 patients (45.6%) remained in VSC, 106 (36.6%) were discharged, 47 (16.2%) returned to face-to-face clinic or treatment, and 5 (1.7%) had emergency admissions. […] Conclusion: Nurse-led VSC not only provided a safe follow-up but also allowed to substantially reduce the cost of treatment by allowing patients to be either discharged or return to a face-to-face clinic or surgical intervention if needed. | 2020-08-01 |
| 32731868 | The COVID-19 pandemic offers a unique opportunity to reshape and update addiction treatment networks. […] Renewed treatment systems should be based on these seven pillars: (1) telemedicine and digital solutions, (2) hospitalization at home, (3) consultation-liaison psychiatric and addiction services, (4) harm-reduction facilities, (5) person-centered care, (6) promote paid work to improve quality of life in people with substance use disorders, and (7) integrated addiction care. […] The heroin pandemic four decades ago was the last time that addiction treatment systems were updated in many western countries. […] A revised and modernized addiction treatment network must include improved access to care, facilitated where appropriate by technology; more integrated care with addiction specialists supporting non-specialists; and reducing the stigma experienced by people with SUDs. | 2020-08-01 |
| 32731913 | Because the pandemic is growing rapidly, it is important to consider diverse treatment options to effectively treat people worldwide. […] The use of stem cells as treatment options has gained tremendous momentum in the past decade. […] The MSCs and MSCExos have immunomodulatory functions; they can be used as therapy to strike a balance in the immune cells of patients with COVID-19. | 2020-08-01 |
| 32732010 | During hospitalization, 8 (10%) developed acute respiratory distress syndrome, and 14 (18%) required mechanical ventilation. 19 (24%) patients were treated with primary Percutaneous Coronary Intervention (PCI) and 59 (76%) were treated with fibrinolytic therapy. 13 (17%) patients required cardiac resuscitation, and 9 (11%) died. […] A total of 5 patients (26%) died during hospitalization. 50 (85%) of the 59 patients initially treated with fibrinolytic therapy had successful fibrinolysis. | 2020-08-01 |
| 32732190 | Randomised clinical trials in which people with suspected, probable, or confirmed covid-19 were randomised to drug treatment or to standard care or placebo. | 2020-08-01 |
| 32732229 | A single heat treatment rendered SARS-CoV-2 undetectable in all mask samples. | 2020-08-01 |
| 32732245 | The outbreak of COVID-19 posed the issue of urgently identifying treatment strategies. […] Cox proportional hazards regression survival analysis showed that a lower risk of death was independently associated with colchicine treatment (HR=0.151 (95% CI 0.062 to 0.368), p<0.0001), whereas older age, worse PaO2/FiO2, and higher serum levels of ferritin at entry were associated with a higher risk. […] This proof-of-concept study may support the rationale of use of colchicine for the treatment of COVID-19. | 2020-08-01 |
| 32732260 | Given the clinical and epidemiological complexity of COVID-19, patiens with heart failure may require particular care since the viral infection has been identified, considering an adequate re-evaluation of medical therapy and a careful monitoring during ventilation. | 2020-08-01 |
| 32732316 | No patients with a presumed rather than confirmed diagnosis were started on anti-tumour necrosis factor (TNF) therapy.Most IBD follow-up appointments were able to occur using phone/webcam or face to face. […] To date, therapy and review of known paediatric patients with IBD has continued. | 2020-08-01 |
| 32732352 | What is the role of remdesivir in the treatment of severe covid-19? […] Remdesivir has received worldwide attention as a potentially effective treatment for severe covid-19. […] Most patients with severe covid-19 would likely choose treatment with remdesivir given the potential reduction in time to clinical improvement. | 2020-08-01 |
| 32732512 | Patients with CAD also had significantly higher inpatient mortality (31% vs 20%, P = 0.046) and need for renal replacement therapy (33% vs 11%, P < 0.0001) compared to the non-CAD group. […] Patients with CAD and COVID-19 have higher rates of comorbidities, inpatient mortality and need for renal replacement therapy compared to their non-CAD counterparts. | 2020-08-01 |
| 32732634 | Among PWH, the median (interquartile range) CD4 T-cell count was 624 (475, 811) cells/μl; 98.7% were on antiretroviral therapy. | 2020-08-01 |
| 32732744 | The rehabilitation therapy was begun on day 6. | 2020-08-01 |
| 32732746 | The COVID-19 pandemic affects a large number of patients with a rapid progression of respiratory failure often requiring hospitalization or intensive care unit treatment in some patients. […] Seventeen patients (61%) needed previous intensive care unit treatment in the acute care hospital. | 2020-08-01 |
| 32732883 | These organic changes, emerging in concert with environmental stress caused by experiences of intensive therapy wards, pandemic fears and social restrictions, promote neuropsychiatric pathologies including major depressive disorder, bipolar disorder (BD), various psychoses, obsessive-compulsive disorder and post-traumatic stress disorder. | 2020-08-01 |
| 32733001 | Finally, we find that IFN-β treatment effectively blocks SARS-CoV-2 replication. | 2020-08-01 |
| 32733003 | This perspective has critical implications for treatment. | 2020-08-01 |
| 32733404 | We describe possible non-antibiotic treatment options, when small molecule drugs have no effect on the bacterial pathogen and explore the potential of phage therapy and phage-derived therapeutic proteins and strategies in treating secondary bacterial infections, including their application in combination with chemical antibiotics. | 2020-08-01 |
| 32733488 | Here, we propose trehalose as a potential preventative treatment for SARS-CoV-2 infection and transmission. | 2020-08-01 |
| 32733668 | By searching PubMed and the Cochrane Library, we selected the most updated systematic reviews of randomised trials on the pharmacological treatment of delirium in both intensive and non-intensive care settings, and on the treatment of agitation related to acute psychosis or dementia. […] We identified medications performing significantly better than placebo or haloperidol as the reference treatment in each population considered, and assessed the strength of association according to validated criteria. […] Despite limitations related to the rapid review methodology and the use of data from indirect populations, the evidence retrieved can pragmatically support treatment choices of frontline practitioners involved in the COVID-19 outbreak, and indicate future research directions for the treatment of delirium in particularly vulnerable populations. | 2020-08-01 |
| 32733692 | To provide guidance on the management of patients with advanced chronic kidney disease (CKD) not requiring kidney replacement therapy during the COVID-19 pandemic. […] We identified 11 broad areas of advanced CKD care management that may be affected by the COVID-19 pandemic: (1) clinic visit scheduling, (2) clinic visit type, (3) provision of multidisciplinary care, (4) bloodwork, (5) patient education/support, (6) home-based monitoring essentials, (7) new referrals to multidisciplinary care clinic, (8) kidney replacement therapy, (9) medications, (10) personal protective equipment, and (11) COVID-19 risk in CKD. | 2020-08-01 |
| 32733710 | The patient tested positive for COVID-19 and required intensive care treatment for ventilation and haemofiltration. | 2020-08-01 |
| 32733765 | In this article, we summarise some evidence on the various steps in SARS-CoV-2 pathogenesis and immune evasion strategies to assess their contribution to our understanding of unresolved problems related to SARS-CoV-2 prevention, control, and treatment protocols. | 2020-08-01 |
| 32733775 | To address the indisputably urgent need for therapeutics for COVID-19, a specialized interdisciplinary medical panel convened in Shanghai in March 2020 to consider all relevant clinical and experimental evidence on the possible utility of intravenous (IV) ascorbate in the treatment of COVID-19-related ARDS. […] The Shanghai panel, and a parallel medical group in Guangzhou, are advising the use of high-dose IV ascorbate for the treatment of ARDS, along with other supportive therapies, including Vitamin D and zinc. […] We report preliminary progress in using this treatment for 50 consecutive cases treated in Shanghai hospitals, consistent with earlier reports from a meta-analysis of the use of IV ascorbate to treat sepsis. | 2020-08-01 |
| 32733785 | To characterize changes in global gene expression in the hearts and kidneys of rtTA/hACE2 double transgenic (dTg) mice in response to hACE2 overexpression, total RNA extracted from these tissues from dTg mice after doxycycline (Dox) treatment was hybridized to oligonucleotide microarrays. | 2020-08-01 |
| 32733837 | This article reviewed the viral replication, pathogenicity, prevention and treatment strategies. […] With a lack of approved treatment options for this virus, alternative approaches to control the spread of disease is in urgent need. […] Ongoing clinical studies related to possible treatments for COVID-19, potential vaccines, and alternative medication such as natural compounds are also discussed. | 2020-08-01 |
| 32733842 | Confronted with such a highly infectious respiratory disease, the research and development of anti-COVID-19 drugs became an urgent work due to the lack of specific drugs for the treatment of COVID-19. | 2020-08-01 |
| 32733907 | Since there are currently no coded therapies or guidelines for treatment of COVID-19, this study aimed to evaluate the possible role of a specific oral bacteriotherapy as complementary therapeutic strategy to avoid the progression of COVID-19. […] All the patients had fever, required non-invasive oxygen therapy and presented a CT lung involvement on imaging more than 50%. […] A second group of 28 subjects received the same therapy added with oral bacteriotherapy, using a multistrain formulation. | 2020-08-01 |
| 32733908 | In the era of this pandemic, diagnosis of other life-threatening diseases might delay treatment. […] At day 10, treatment response was noticed as indicated by respiratory and renal function improvement. | 2020-08-01 |
| 32733979 | The pediatric orthopaedic practice is in a unique position, with the treatment of many conditions being treated by pediatric orthopedists being non-emergent, but time-sensitive. | 2020-08-01 |
| 32733984 | Here we discuss the issue in terms of clinical severity of COVID-19 pneumonia, priority of orthopedic surgical trauma procedures and standard of care for the treatment of trauma injuries. | 2020-08-01 |
| 32734298 | Although direct comparisons with pre-coronavirus recruitment are difficult due to the recency of the Engage-PD implementation study, this recruitment rate was larger than expected, which may have been due to several factors (eg, most patients had limited, if any, access to in-person programs and therapy services during this time, so the Engage program filled an immediate need to provide exercise and activity guidance). | 2020-08-01 |
| 32734311 | (“Promoting Resilience Among College Student Veterans Through an Acceptance-and-Commitment-Therapy App: An Intervention Refinement Study”, 2020) the importance of repurposing their app to help these users to improve their emotional resilience and subsequently their ability to cope with the trauma of their experience. | 2020-08-01 |
| 32734327 | In the “COVID-19 era”, fast track awake breast surgery provides a reduction of ORT, LOS and potentially surgical treatment for a wider number of oncological patients. | 2020-08-01 |
| 32734438 | Studies described 252 patients, 80.9% were male, the mean age was 52.7 years, and 98% were on antiretroviral treatment (ART). | 2020-08-01 |
| 32734518 | Besides, the possible effective therapeutics’ mechanism and the pharmaceutical agents that had at least one experience as a preclinical or clinical study on COVID-19 were clearly defined. […] The treatment protocol would be occasional based on the stage of the infection and the patient situation. | 2020-08-01 |
| 32734526 | Regarding management of people with STEMI, although the superiority of primary percutaneous coronary intervention (PCI) over thrombolysis is well established, the notable exposure risks due to absence of negative pressure in catheterization rooms and the increased difficulty in fine manipulation on guidewires under proper protection equipment may contribute to the relatively secondary role of PCI during the COVID-19 pandemic; thus, fibrinolytic therapy or robotic-assisted PCI in early presenting STEMI patients may have an alternative role during this period if prevention measures cannot be taken. | 2020-08-01 |
| 32734554 | We wanted to describe the effects of a 6 week shutdown of a large German botulinum toxin (BT) outpatient clinics on patients and their well-being. 45 patients (age 61.9 ± 9.8 years, 29 females, 16 males) receiving BT therapy (319.3 ± 201.9MU-equivalent, treatment duration 8.3 ± 5.5 years) were surveyed with a standardised questionnaire. […] The shutdown delayed BT therapy by 6.6 ± 2.3 weeks. 93% of the patients noticed increased muscle cramps and 82% increased pain reducing their quality of life by 40.2 ± 19.5%. […] After the shutdown 66% of patients perceived BT therapy as more important than before, 32% perceived it as unchanged. […] For all patients long-term availability of BT therapy was very important or important. 98% of the patients perceived the shutdown as inadequate and felt their patient rights not respected. […] The shutdown confirmed the considerable burden of disease caused by dystonia, spasticity, hemifacial spasm and various pain conditions and the importance of BT therapy to treat them. | 2020-08-01 |
| 32734556 | The SAA levels of all patients were recorded and compared on 1 day after admission (before treatment) and 3 days, 5 days, and 7 days after treatment. […] The difference of comparison of SAA between survival group and non-survival group before treatment was not statistically significant, Z1 = - 1.426, P = 0.154. […] The Z1 values (Z1 is the Z value of the rank sum test) of the two groups of patients at 3 days, 5 days, and 7 days after treatment were - 5.569, - 6.967, and - 7.542, respectively. […] The ROC curve results showed that SAA has higher sensitivity to the prognostic value of 1 day (before treatment), 3 days, 5 days, and 7 days after treatment, with values of 0.806, 0.972, 0.861, and 0.961, respectively. | 2020-08-01 |
| 32734609 | The COVID-19 outbreak and the subsequent declaration of pandemic was an unprecedented event, which created different complex situations for treatment of cancer patients. […] Analysis of the impact on healthcare was done by comparing the number of patients taking treatment in the lockdown period in India with the previous year’s data in the same corresponding period in all three departments. […] The treatment of patients with cancer should not be delayed, even in times of a pandemic. | 2020-08-01 |
| 32734626 | Surgical treatment of T3/T4 melanomas should be prioritized over T1/T2 melanomas except for any melanoma in which large clinical residual lesion is visible. […] PD-1 inhibitor monotherapy is recommended for patients starting immunologic therapy. […] Encorafenib and binimetinib should be prioritized for patients requiring BRAF-targeted therapy due to the lower chance of symptoms mimicking COVID-19 infection. | 2020-08-01 |
| 32734777 | The high mortality in COVID-19 associated ARDS necessitates a prompt and aggressive treatment strategy which includes corticosteroids. […] Most of the studies included no information on the dosing regimen of corticosteroid therapy, however, low-dose corticosteroid therapy or pulse corticosteroid therapy appears to have a beneficial role in the management of severely ill COVID-19 patients. | 2020-08-01 |
| 32734810 | With the emergence of a novel severe acute respiratory syndrome coronavirus, investigators worldwide are scrambling to identify appropriate treatment modalities, develop accurate testing, and produce a vaccine. […] To date, effective treatment remains elusive. […] Chloroquine phosphate and hydroxychloroquine sulfate (HCQ), well-known antimalarial drugs effective in the treatment of systemic lupus erythematosus, rheumatoid arthritis, porphyria cutanea tarda, and chronic Q fever, are currently under investigation. […] The United States Food and Drug Administration recently issued an Emergency Use Authorization for CQ and HCQ use in the treatment of coronavirus disease 2019 (COVID-19). | 2020-08-01 |
| 32734828 | The identified compounds in this study are expected to support the global drug discovery efforts in fighting against this highly contagious virus by narrowing the searchable chemical space for potential effective therapeutics. | 2020-08-01 |
| 32734862 | Acute treatment with all-trans retinoic acid and cytoreduction was started and coagulation parameters corrected. | 2020-08-01 |
| 32734864 | Glucose levels should be monitored rigorously, and patient-tailored aggressive treatment of hyperglycaemia is recommended, often with the use of insulin. | 2020-08-01 |
| 32734910 | A set of online questionnaires were used to measure mental problems (i.e., anxiety, insomnia, and depressive symptoms), and help-seeking behavior and treatment for these mental problems. […] 4.5%, adjusted OR=1.00, 95% CI=0.53-1.87) or treatment (3.4% vs. […] Frontline medical workers had more mental problems but comparable help-seeking behaviors and treatment for these problems than non-frontline medical workers. | 2020-08-01 |
| 32735134 | The disease affects healthy young adults and commonly has a benign course, however, if complications such as macular edema or ischemia appears, treatment should be instituted immediately to avoid poor prognosis. | 2020-08-01 |
| 32735170 | Although of high utility in the management of HAPE and acute mountain sickness, systemically delivered pulmonary vasodilators and acetazolamide should not be used in the treatment of COVID-19, as they carry the risk of multiple adverse consequences, including worsened ventilation-perfusion matching, impaired carbon dioxide transport, systemic hypotension, and increased work of breathing. | 2020-08-01 |
| 32735326 | Since the initial reports of the association between hypovitaminosis D and COVID-19, Vitamin D has been pointed as a potentially interesting treatment for SARS-Cov-2 infection We provide an overview on the current status of vitamin D deficiency, the mechanisms of action of vitamin D and the current literature on the topic, with a special focus on the potential implications for COVID-19 pandemic. | 2020-08-01 |
| 32735386 | Our study highlights the common efforts of GCT experts in Europe and Canada to maintain high standards of treatment for patients with GCT with few changes in their management during the COVID-19 pandemic. | 2020-08-01 |
| 32735457 | The National Institute for Public Health of the Netherlands published a report for guidance on diagnosis, prevention and treatment of thromboembolic complications in COVID-19 with a new vascular disease concept. […] Therefore anticoagulant profylaxis, close lab and CT imaging monitoring and early anticoagulant therapy are indicated. | 2020-08-01 |
| 32735546 | We believe, however, the full treatment to be a multifaceted, adjuvant approach where multiple drugs may need to be taken at the same time. | 2020-08-01 |
| 32735699 | The revolution of surgical and interventional therapy of structural heart disease has had ’profoundly positive effects on survival and quality of life over the decades. […] Personalized medicine, rapid genetic diagnostics, RNA and extracellular vesicle biology, epigenetics, gene editing, gene and stem cell-derived therapy are exemplary areas where specialized training for paediatric/congenital cardiology physician scientists will be increasingly needed to further advance the field. | 2020-08-01 |
| 32735768 | In such trials, careful attention must be paid to the duration of the treatment, the onset of beneficial effects, and the severity of the disease, otherwise, the outcomes may still remain inconclusive. | 2020-08-01 |
| 32735810 | We chose the most user-friendly, easily scalable viral decontamination methods, including ultraviolet irradiation and heat treatment. | 2020-08-01 |
| 32735883 | Due to the lack of specific medication and vaccination, drug-repurposing attempts has emerged as a promising approach and identified several human proteins interacting with the virus. | 2020-08-01 |
| 32735965 | Finite clinical data and understanding of COVID-19 immunopathology has led to limited, opinion-based recommendations for the management of patients with immune-mediated inflammatory disease (IMID) receiving immunosuppressive (IS) therapeutics. […] We conducted a retrospective cohort analysis of Henry Ford Health System patients tested for COVID-19 between February 1 and April 18, 2020, treated with IS medication for IMID. […] Therapeutic class of IS medication, comorbidities, and demographic factors were combined into multivariate models to determine predictors of COVID-19 infection, admission, ventilation, and mortality. | 2020-08-01 |
| 32736007 | There are currently limited data on the epidemiology, clinical manifestations, and optimal management of Coronavirus Disease 2019 (COVID-19) in hematopoietic cell transplantation and cellular therapy recipients. […] These guidelines were developed by members of the American Society for Transplantation and Cellular Therapy Infectious Diseases Special Interest Group. | 2020-08-01 |
| 32736027 | Treatment consists in anticoagulation and antiaggregant drugs and thrombectomy. […] Preventing venous thromboembolism treatment is recommended in case of severe infection or in the ICU, but there is no clear recommendation for arterial thromboembolism prevention. | 2020-08-01 |
| 32736197 | The epidemiological, demographic, clinical, laboratory, treatment, and outcome data were collected. | 2020-08-01 |
| 32736237 | The aim of the present study was to identify the clinical efficacy of glucocorticoid therapy on the treatment of patients with Coronavirus Disease 2019 (COVID-19) pneumonia. […] Clinical and laboratory parameters were collected from 308 patients with COVID-19 pneumonia from the fever clinic of Wuhan Pulmonary Hospital (Wuhan City, Hubei Province, China) between January 14, 2020 and February 9, 2020, of which 216 patients received low-dose (equivalent of methylprednisolone 0.75-1.5 mg/kg/d) glucocorticoid treatment. […] Lymphocyte count and C-reactive protein (CRP) significantly differed between the glucocorticoid therapy and non-glucocorticoid therapy groups. […] Compared with the non-glucocorticoid therapy group, glucocorticoid therapy did not significantly influence the clinical course of COVID-19 pneumonia, including imaging progress and the time duration for negative transformation of nucleic acid. […] Glucocorticoid therapy did not significantly influence the outcomes nor the adverse events of COVID-19 pneumonia. […] For the treatment of COVID-19 pneumonia, systemic and in-depth investigation is needed to determine the timing and dosage of glucocorticoids needed to inhibit overwhelming inflammatory response and not the protective immune response to COVID-19 pneumonia. | 2020-08-01 |
| 32736332 | In this work, the objective is to determine an optimal control strategy for vaccine administration in COVID-19 pandemic treatment considering real data from China. […] Two optimal control problems (mono- and multi-objective) to determine a strategy for vaccine administration in COVID-19 pandemic treatment are proposed. […] The first consists of minimizing the quantity of infected individuals during the treatment. […] The second considers minimizing together the quantity of infected individuals and the prescribed vaccine concentration during the treatment. | 2020-08-01 |
| 32736369 | Therapeutic BAL might improve regional ventilation for COVID-19 and EIT could be a useful tool at the bedside to monitor the ventilation treatment of COVID-19. | 2020-08-01 |
| 32736393 | It is estimated that around 28 million surgeries will be postponed or canceled worldwide as a result of this pandemic, causing a delay in the diagnosis and treatment of more than 2 million cancer cases. […] However, some women need treatment for various gynecological diseases that cannot be postponed. […] The purpose of this article is to present recommendations on surgical treatment during the COVID-19 pandemic. | 2020-08-01 |
| 32736468 | Surgical treatment of lung cancer in the conditions of the COVID-19 pandemic poses new challenges to ensure the perioperative safety of patients. […] In the conditions of the COVID-19 pandemic within two months (March-April 2020) 138 patients underwent surgical treatment for malignant tumors, including 22 videothoracoscopic operations: 3 (13.6%) segmentectomies, 16 (72.7%) lobectomies, and 5 (22.7%) bilobectomies for non-small cell lung cancer. […] Following the principles that ensure the prevention of infection and the prevention of severe COVID-19, we managed to avoid the first stage of the pandemic (March-April 2020) cases of infection with a new coronavirus infection in patients who underwent surgical treatment for lung cancer. | 2020-08-02 |
| 32736485 | Palliative care services face challenges in adapting and responding to the COVID-19 pandemic. […] Understanding how palliative care needs and outcomes have changed during the pandemic compared to before the pandemic is crucial to inform service planning and research initiatives. […] To evaluate the impact of COVID-19 on symptoms, clinical characteristics, and outcomes for patients referred to a hospital-based palliative care service in a district general hospital in London, UK. […] The first 60 inpatients with confirmed COVID-19 infection, referred to the hospital palliative care service between 1 March 2020 and 23 April 2020, and another 60 inpatients, referred to the hospital palliative care service between 11 March 2019 and 23 April 2019, were included from a district general hospital in East London, UK. […] Time from admission to referral to palliative care is longer for Black, Asian and minority ethnic patients, especially during COVID-19. […] Early referral to palliative care is essential in COVID-19, especially for Black, Asian and minority ethnic groups. […] There is urgent need to research why Black, Asian and minority ethnic patients are referred late; how palliative care services have changed; and possible solutions to setting up responsive, flexible, and integrated services. | 2020-08-02 |
| 32736486 | Hospital palliative care is an essential part of the COVID-19 response, but relevant data are lacking. […] The recent literature underscores the need to implement protocols for symptom control and the training of non-specialists by palliative care teams. […] The aim of the study was to describe a palliative care unit’s consultation and assistance intervention at the request of an Infectious Diseases Unit during the COVID-19 pandemic, determining what changes needed to be made in delivering palliative care. […] This study was conducted in the Palliative Care Unit of the AUSL-IRCCS hospital of Reggio Emilia, which has no designated beds, consulting with the Infectious Diseases Unit of the same hospital. […] A total of 9 physicians and 22 nurses of the Infectious Diseases Unit and two physicians of the Palliative Care Unit participated in the study.Our Palliative Care Unit developed a feasible 18-day multicomponent consultation intervention. […] From the perspective of palliative care, some changes in usual care needed to be made. | 2020-08-02 |
| 32736493 | The aim of this audit was to assess the utility of our end-of-life care plan, and specifically the effectiveness of our standardised end-of-life care treatment algorithms, in dying patients with COVID-19. […] The audit primarily involved data extraction from the end-of-life care plan, which includes four hourly nursing (ward nurses) assessments of specific problems: patients with problems were managed according to standardised treatment algorithms, and the intervention was deemed to be effective if the problem was not present at subsequent assessments. | 2020-08-02 |
| 32736494 | Only five studies met the inclusion criteria, highlighting a striking lack of evidence base for the response of primary healthcare services in palliative care during epidemics and pandemics. […] As the COVID-19 pandemic progresses, there is an urgent need for research to provide increased understanding of the role of primary care and community nursing services in palliative care, alongside hospices and community specialist palliative care providers. | 2020-08-02 |
| 32736592 | EDP1815 will be given as 2 capsules twice daily (1.6 x 1011 cells) for up to 7 days with the option to extend up to 14 days at the discretion of the principal investigator or their delegate, if the patient is felt to be clinically responding to treatment, is tolerating treatment, and is judged to be likely to benefit from a longer treatment course. […] Eligible patients will be randomised using a central web-based randomisation service (Sealed Envelope) in a 1:1:1 ratio, stratified by site to one of the treatment arms or standard of care. | 2020-08-02 |
| 32736596 | ACCORD is a seamless, Phase 2, adaptive, randomised controlled platform study, designed to rapidly test candidate agents in the treatment of COVID-19. […] The study will include hospitalised adult patients (≥18 years) with confirmed SARS-CoV-2 infection, the virus that causes COVID-19, that clinically meet Grades 3 (hospitalised - mild disease, no oxygen therapy), Grades 4 (hospitalised, oxygen by mask or nasal prongs) and 5 (hospitalised, non-invasive ventilation or high flow oxygen) of the WHO Working Group on the Clinical Characteristics of COVID-19 9-point category ordinal scale. […] Comparator is current standard of care (SoC) for the treatment of COVID-19. […] ACCORD is linked with the UK national COVID therapeutics task force to help prioritise candidate agents. | 2020-08-02 |
| 32736597 | The main objective of the present study is to evaluate the efficacy of hydroxychloroquine for (I) the prevention of COVID-19 or related symptoms in SARS-CoV-2-exposed subjects, such as as household members/contacts of COVID-19 patients and (II) the treatment of early-phase asymptomatic or paucisymptomatic COVID-19 patients. […] SARS-CoV-2-exposed subjects, including household members and/or contacts of COVID-19 patients and healthcare professionals (Group 1) or patients with COVID-19 (positive PCR test on a rhinopharyngeal or oropharyngeal swab for SARS-CoV-2), asymptomatic or paucisymptomatic in home situations who are not undergoing treatment with any anti COVID-19 medication (Group 2), will be enrolled. […] All subjects must be aged ≥18 years, male or female, must be willing and able to give informed consent and must not have any contraindications to take hydroxychloroquine (intolerance or previous toxicity for hydroxychloroquine/chloroquine, bradycardia or reduction in heart rhythm with arrhythmia, ischemic heart disease, retinopathy, congestive heart failure with use of diuretics, favism or glucose-6-phosphate dehydrogenase (G6PD) deficiency, diabetes type 1, major comorbidities such as advanced chronic kidney disease or dialysis therapy, known history of ventricular arrhythmia, any oncologic/hematologic malignancy, severe neurological and mental illness, current use of medications with known significant drug-drug interactions, and known prolonged QT syndrome or current use of drugs with known QT prolongation). […] Hydroxychloroquine will be administered with the following schedule: Group1: A loading dose hydroxychloroquine 400 mg twice daily on day 1, followed by a weekly dose of hydroxychloroquine 200 mg twice daily on days 8, 15 and 22, for a total of one month of treatment. […] The comparator in this trial is observation given that currently neither treatment is administered to asymptomatic or paucisymptomatic subjects, nor prophylaxis is available for contacts. […] During treatment, each subject will be contacted every other day for the first week and weekly thereafter (Group 2) or weekly (Group 1) by a study physician to assess early onset of any COVID-19 symptom or any adverse reaction to hydroxychloroquine and to check subject compliance. […] Index case with COVID-19 treatment (yes vs. no) An independent statistician not otherwise involved in the trial will generate the allocation sequence, and COVID-19 response teams will be unaware of the allocation of clusters. | 2020-08-02 |
| 32736887 | On April 14, the Society of Swallowing and Dysphagia of Japan (SSDJ) proposed its position statement on dysphagia treatment considering the ongoing spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). […] Dysphagia treatment includes a broad range of clinical assessments and examinations, dysphagia rehabilitation, oral care, nursing care, and surgical treatments. […] In terms of proper infection control measures, all healthcare professionals involved in dysphagia treatment must be fully briefed and must appropriately implement all measures. […] Accordingly, the SSDJ proposes specific infection countermeasures that should be implemented considering 1) the current status of SARS-CoV-2 infection in the region, 2) the patient status of SARS-CoV-2 infection, and 3) whether the examinations or procedures conducted correspond to aerosol-generating procedures, depending on the status of dysphagia treatment. […] This statement is arranged into separate sections providing information and advice in consideration of the COVID-19 outbreak, including “terminology”, “clinical swallowing assessment and examination”, “swallowing therapy”, “oral care”, “surgical procedure for dysphagia”, “tracheotomy care”, and “nursing care”. […] The current set of statements on dysphagia management in the COVID-19 outbreak is not an evidence-based clinical practice guideline, but a guide for all healthcare workers involved in the treatment of dysphagia during the COVID-19 epidemic to prevent SARS-CoV-2 infection. | 2020-08-02 |
| 32736906 | The rationale, concerns, and possible side effects of specific therapeutic measures, including anticoagulants, renin-angiotensin-aldosterone system inhibitors, and anti-inflammatory/antiviral medications applied to the treatment of COVID-19 are also discussed. | 2020-08-02 |
| 32736981 | During the surge phase, treatment should broadly be limited to those at increased risk of complications in the near term. […] During the peak phase, treatment should be limited to inpatients for whom it may facilitate discharge. | 2020-08-02 |
| 32737082 | There is uncertainty as to the contribution of patients’ demographics and oncological features on severity and mortality from Covid-19 and little guidance as to the role of anti-cancer and anti-Covid-19 therapy in this population. […] Provision of chemotherapy, targeted therapy and immunotherapy did not worsen mortality. […] This study highlights the clinical utility of demographic factors for individualized risk-stratification of patients and support further research into emerging anti-Covid-19 therapeutics in SARS-Cov-2 infected cancer patients. | 2020-08-02 |
| 32737100 | All randomised clinical trials investigating the safety and efficacy of favipiravir compared with other control groups for the treatment of patients with confirmed infection with SARS-CoV-2 will be included. […] Patients’ survival at the end of the treatment as well as the follow-up will be the primary outcome of the treatment, followed by the time and rate of the patient with a negative COVID-19 test. | 2020-08-02 |
| 32737101 | We will investigate the development of these psychological disturbances in HCPs at the treatment front line and second line during the COVID-19 pandemic over a 12-month period in different countries. | 2020-08-02 |
| 32737423 | Finally, we review evidence on the use of antihypertensive medication, namely, ACE inhibitors and angiotensin receptor blockers, in patients with COVID-19. | 2020-08-02 |
| 32737471 | Overall, this study provides an example for exploring the in vitro potency of Chinese traditional patent medicines and effectively identifying bioactive ingredients toward a specific target, and gains evidence supporting the in vivo studies of Shuanghuanglian oral liquid as well as two natural products for COVID-19 treatment. | 2020-08-02 |
| 32737627 | Treatment with glucocorticoids increased the risk of progression from not severe to severe disease (OR 3.79, 95% CI 2.39-6.01, p < 0.001). | 2020-08-02 |
| 32737681 | These could be used as potential molecules or hits for further drug development to obtain clinically useful therapeutic agents for the treatment of COVID-19. | 2020-08-02 |
| 32737746 | The COVID-19 patients at high risk included those with acute respiratory distress syndrome, in intensive care units, receiving broad-spectrum antibiotics, immunosuppressants or corticosteroid, and supported by invasive or noninvasive ventilation. | 2020-08-02 |
| 32737747 | We suggest it is prudent to assess the risk factors, the types of invasive mycosis, the strengths and limitations of diagnostic methods, clinical settings, and the need for standard or individualized treatment in COVID-19 patients. | 2020-08-02 |
| 32737799 | As a result, treatment with lopinavir/ritonavir was initiated, and patient symptoms and signs improved significantly during the course of hospitalization. | 2020-08-02 |
| 32737817 | PrEP/ART continuation were reported by the majority, despite reports of impediments to medication refill. | 2020-08-02 |
| 32738040 | Early adrenal axis testing, as well as directed imaging, is crucial for immediate diagnosis and treatment. […] Four weeks after discharge she had no signs of COVID-19 infection and her polymerase chain reaction test for COVID-19 was negative, but she still needed glucocorticoid and mineralocorticoid replacement therapy. | 2020-08-02 |
| 32738060 | The mode of healthcare and medication use was compared before and after COVID-19 outbreak. | 2020-08-02 |
| 32738140 | A coordinated on-site medicalization program (MP) in response to a sizeable COVID-19 outbreak in four nursing homes was organized, with the objectives of improving survival, offering humanistic palliative care to residents in their natural environment, and reducing hospital referrals. […] Ten key processes and interventions were established (provision of informatics infrastructure, medical equipment, and human resources, universal testing, separation of ‘clean’ and ‘contaminated’ areas, epidemiological surveys, and unified protocols stratifying for active or palliative care approach, among others). […] Main outcomes were a composite endpoint of survival or optimal palliative care (SOPC), survival, and referral to hospital. 272 out of 457 (59.5%) residents and 85 out of 320 (26.5%) staff members were affected. […] The SOPC was independently associated to MP (OR=15 [3-81]); and survival in patients stratified to active approach, to the use of any antiviral treatment (OR=28 [5-160]). […] A coordinated on-site medicalization program of nursing homes with COVID-19 outbreaks achieved a higher survival or optimal palliative care rate, and a reduction in referrals to hospital, thus ensuring rigorous but also humanistic and gentle care to residents. | 2020-08-02 |
| 32738184 | Identifying other target proteins is of high importance as targeting the alternative receptors for SARS-CoV-2 might open up a promising avenue for the treatment of COVID-19 patients, including those who have cancer. | 2020-08-02 |
| 32738193 | There is an urgent need for vaccines and therapeutics to prevent and treat COVID-19. […] Our findings underscore the utility of rVSV-SARS-CoV-2 S for the development of spike-specific therapeutics and for mechanistic studies of viral entry and its inhibition. | 2020-08-02 |
| 32738257 | Consequently, we conclude that treatment with renin-angiotensin-aldosterone-system inhibitors should not be discontinued and, therefore, these therapies should not be interrupted. | 2020-08-02 |
| 32738287 | We screened for psychiatric symptoms 402 adults surviving COVID-19 (265 male, mean age 58), at one month follow-up after hospital treatment. | 2020-08-02 |
| 32738305 | Here we review the underlying biological mechanisms of Lf as an antiviral and immune regulator, and propose its unique potential as a preventative and adjunct treatment for COVID-19. | 2020-08-02 |
| 32738360 | Currently, no proper medicine or effective treatment strategies are available; therefore, repurposing of FDA approved drugs may play an important role in overcoming the situation. | 2020-08-02 |
| 32738497 | With the increasing number of COVID-19 cases in the United States, more data is being reported on transmission, symptomatology, clinical course, and treatment of the virus. | 2020-08-02 |
| 32738870 | Pharmacists are permitted to provide medication management reviews via telehealth. […] Anticipatory prescribing and medication imprest systems are valuable for access to end-of-life medications within residential aged care. | 2020-08-03 |
| 32739134 | In this moments, of extreme gravity in which we find ourselves, and in the uncertainty face about the most effective treatment against COVID-19 disease and with the aim of find the evidence that support the chloroquine/hydroxychloroquine use recommendation to treat COVID-19 disease, a systematic review of published studies and RCT studies publishes until April 28, 2020 was carried out. | 2020-08-03 |
| 32739174 | Although they emerged in the early period of the twenty first century, resilient biomedical and expertise in pharmaceutical domain could not appropriate any proprietary therapeutics. […] The review unravels key events involved in the lifecycle of SARS-CoV-2 while highlighting the possible avenues of therapy. | 2020-08-03 |
| 32739381 | Secondary analysis of 5974 HAPO study women with singleton pregnancies who underwent 75 g OGTTs and HbA1c assays between 24 and 32 weeks’ gestation and who received no treatment for GDM. | 2020-08-03 |
| 32739404 | CVC is currently under clinical trials in the patients for treatment of nonalcoholic steatohepatitis, in which immune cell activation and dysregulation of proinflammatory cytokines play an important role in its pathogenesis. […] Considering the fact that the regulation of excessive immune activation is required to treat COVID-19 patients at the late stage of the disease, CVC should be further pursued for its potential in the treatment of SARS-CoV-2 infection. | 2020-08-03 |
| 32739424 | Clinicians should pay more attention to the monitoring and treatment of COVID-19 patients with AKI. | 2020-08-03 |
| 32739908 | In this category of pregnant women, use of low-molecular-weight heparins (LMWH) is particularly important for both prevention of vascular and obstetric complications, and for pathogenetic therapy of COVID-19. | 2020-08-03 |
| 32739959 | Here, biomarkers of coagulation (such as D-dimer, fibrinogen, platelet count), inflammation (such as interleukin-6) and immunity (such as lymphocyte count) as well as clinical scoring systems (such as SOFA, ISTH DIC and SIC score) can be helpful in predicting clinical course, need for hospital resources (such as ICU beds, intubation and ventilator therapy, and ECMO) and patient’s outcome in patients with COVID-19. […] However, therapeutic options are actually limited to unspecific supportive therapy. | 2020-08-03 |
| 32740062 | Multiple therapeutic options are being explored across a variety of medication classes with diverse ocular side effects. | 2020-08-03 |
| 32740069 | They enable risk stratifying patients based on individual risk of vision-threatening diabetic retinopathy including diabetic macular edema (DME), and predicting which patients with DME best respond to antivascular endothelial growth factor therapy. | 2020-08-03 |
| 32740371 | The effectiveness of lopinavir/ritonavir (LPV/r) and chloroquine treatment for COVID-19 has not been verified. […] The main outcome measurements include the changes of cycle threshold values of open reading frame 1 ab (ORF1ab) and nucleocapsid (N) genes by reverse transcriptase-polymerase chain reaction assay from day 1 to 7 after admission for patients receiving standard care or after treatment being initiated for patients receiving either LPV/r or chloroquine. […] The median increase in cycle threshold values of N and ORF1ab gene for patients receiving LPV/r or chloroquine or the standard care during the treatment course was 7.0 and 8.5, 8.0, and 7.6, 5.0, and 4.0, respectively. […] Antiviral therapy using LPV/r or chloroquine seemed not to improve the prognosis or shorten the clinical course of COVID-19. | 2020-08-03 |
| 32740801 | However, there are currently no approved antiviral drugs for the COVID-19 treatment. […] Preliminary clinical evidence suggests these drugs may have an effect on the treatment of COVID-19. […] Herein, we review the pharmacokinetics characteristics and antiviral effects of these drugs, in addition to their side effects and clinical evidence of their use for the COVID-19 treatment. | 2020-08-03 |
| 32740858 | To date, only remdesivir and dexamethasone have demonstrated a positive response in a prospective, randomized trial for the treatment of patients with COVID-19. […] Unfortunately, results of randomized trials evaluating HCQ as treatment against a control group are lacking, and little is known about its pharmacokinetic/pharmacodynamic (PK/PD) profile against SARS-CoV-2. | 2020-08-03 |
| 32740890 | Mesenchymal stem cell (MSC) therapy has been shown to alleviate pneumonia and acute respiratory syndrome (ARDS) symptoms, through their immunomodulatory activities in COVID-19 patients. […] Results from clinical trials are encouraging as patients treated with MSCs, regain lung functions and have restored levels of cytokines and trophic factors underscoring the fact that stem cell therapy can be, at least, a complementary therapy to alleviate sufferings in COVID-19 patients. | 2020-08-03 |
| 32741139 | Included studies described one or more relevant clinical outcomes in five or more people who were infected with SARS-CoV-2 and were treated with antirheumatic disease therapy between 01/01/2019 and 05/29/2020. | 2020-08-03 |
| 32741160 | The management of asymptomatic cases now in China focuses on isolation and medical observation according to the guideline of “early detection, early report, early isolation and early treatment” . | 2020-08-04 |
| 32741218 | Through this narrative review, we provide an evidence-based overview of idiopathic and secondary chilblains, distinguishing features of COVID-19 chilblains, and a systematic clinical approach to history, examination, investigations, and treatment. | 2020-08-04 |
| 32741322 | The results in this study can be used for the treatment of COVID-19 and can also form the basis of rational drug design against NSP16 of SARS-CoV-2. | 2020-08-04 |
| 32741386 | For patients receiving intravenous tPA treatment, we also found a significant increase (p = 0.005) in the median door-to-needle time (61 min, IQR: 46-72 min vs. 37 min, IQR: 30-50 min). […] We detected an increase in our institutional time to treatment metrics for acute ischemic stroke patients receiving tPA and/or endovascular reperfusion therapies, related to delays from hospital presentation to the acquisition of cranial CT imaging for both tPA- and EVT-treated patients, and an added delay to treatment with tPA. | 2020-08-04 |
| 32741691 | In some regions, urology residents have been deployed to emergency rooms, intensive care units, and medical floors to care for COVID-19 patients. | 2020-08-04 |
| 32741697 | An alternative way of treatment could be the use of naturally derived molecules with known antiviral properties. […] This review summarizes the available reports and evidences which support the use of tea polyphenols as potential candidates in prophylaxis and treatment of COVID-19. | 2020-08-04 |
| 32741731 | Due to the higher transmissibility and infectiousness, asymptomatic infection, and lack of effective treatment options and vaccine, fatalities and morbidities are increasing day by day globally. | 2020-08-04 |
| 32741930 | Current clinical examinations for treatment and discharge standard are limited to respiratory samples. | 2020-08-04 |
| 32741931 | Repeated monitoring of ferritin, interleukin-6, C-reactive protein, lactic acid dehydrogenase, and erythrocyte sedimentation rate during COVID-19 treatment may assist the prediction of disease severity and evaluation of treatment effects. […] Repeated monitoring of ferritin, interleukin-6, C-reactive protein, lactic acid dehydrogenase, and erythrocyte sedimentation rate during COVID-19 treatment may assist the prediction of disease severity and evaluation of treatment effects. | 2020-08-04 |
| 32742146 | While strategies have been implemented to improve external validity with greater participation among all segments of the population in RCTs, the coronavirus disease 2019 (COVID-19) pandemic may exacerbate disparities in RCT participation with the potential impact of delaying treatment development and vaccine interventions that are applicable and generalizable. | 2020-08-04 |
| 32742294 | Herein, we present the case of a 14-year-old girl with systemic lupus erythematosus, who developed hyperpigmentation on her shins and dorsum of the left foot, approximately 3 years after initiating treatment with HCQ. | 2020-08-04 |
| 32742314 | Proper recommendations have been proposed for a wide range of respiratory disorders including chronic obstructive pulmonary disease (COPD), asthma and interstitial lung diseases, regarding the continuation or not of the treatment during this period and ways to maintain stability. | 2020-08-04 |
| 32742564 | Cell therapy is a promising therapeutic strategy for refractory and unmanageable pulmonary illnesses, as proved by accumulating preclinical studies. […] In this review, we systematically summarize the global trends for the cell therapy of common airway and lung diseases registered for clinical trials. | 2020-08-04 |
| 32742639 | Heat is a cheap, convenient and widely accessible therapeutic modality and while no clinical protocols exist for using heat to treat COVID-19, protocols that draw from traditional practices and consider contraindications, adverse effects and infection control measures could be developed and implemented rapidly and inexpensively on a wide scale. | 2020-08-05 |
| 32742647 | In the ongoing COVID-19 emergency, the surgical treatment of GD is postponed, resulting in a huge number of untreated patients who could develop severe morbidity. | 2020-08-04 |
| 32742815 | Overall, the exploration of the diversity of these isolates, mutational hotspots and pan-genome will shed light on the evolution and pathogenicity of SARS-CoV-2 and help in developing putative methods of diagnosis and treatment. | 2020-08-04 |
| 32742920 | Under these circumstances, it is important to explore various possibilities for the treatment of COVID-19 including herbal medicines. […] In a number of recent clinical studies, treatment with SSHT improved the infection status of the respiratory and hepatobiliary systems, and experimental studies demonstrated the antiviral effect of SSHT and its components. | 2020-08-04 |
| 32742969 | Treatment of COVID-19 Patients at a Medical College Hospital in Bangladesh. | 2020-08-04 |
| 32742978 | In this review, we summarize the clinical characteristics of COVID-19 induced AKI by focusing on its epidemiology, pathogenesis, clinical diagnosis, and treatment. […] This article reviews the characteristics of COVID-19-induced AKI largely based on up-to-date studies in the hope that it will be helpful in the current global fight against and treatment of COVID-19. | 2020-08-04 |
| 32743022 | Indeed, through the wide innervation of the organism by the vagus nerve, especially the lungs and gastrointestinal tract, VNS appears as a serious candidate for a few side effect treatment that could dampen or prevent the cytokine storm observed in COVID-19 patients with severe symptoms. […] Finally, a continuous vagal tone monitoring in patients with COVID-19 could be used as a predictive marker of COVID-19 illness course but also as a predictive marker of response to COVID-19 treatment such as VNS or others. | 2020-08-04 |
| 32743211 | The current COVID-19 outbreak warrants the design and development of novel anti-COVID therapeutics. | 2020-08-04 |
| 32743622 | This work will enable large scale serosurveillance, which can play an important role in the months and years to come to implement efficient containment and mitigation measures, as well as help develop therapeutics and vaccines to treat and prevent the spread of COVID-19. | 2020-08-04 |
| 32743705 | The aim of the research was to further extend current knowledge of whether severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) disease 2019 (COVID-19) entails a risk for children with various rheumatic diseases under immunosuppressive treatment. […] Patients who were followed-up under immunosuppressive treatment (n = 439) were attempted to be contacted. […] Although circumstances such as compliance in social distancing policy, transmission patterns, attitude following contact may have influenced the results, immunosuppressive treatment does not seem to pose an additional risk in terms of COVID-19. | 2020-08-04 |
| 32743771 | The complete title should be “Remdesivir for Treatment of COVID-19: Combination of Pulmonary and IV Administration May Offer Additional Benefit”. | 2020-08-04 |
| 32743938 | However, it is also currently under discussion whether patients under immunosuppressive therapy also have a higher risk of suffering a severe course of the COVID-19 disease. […] However, since there is currently neither an effective therapy nor corresponding vaccination protection, the indication for a prolonged immunosuppressive therapy should be made with special care. | 2020-08-04 |
| 32743995 | Disease severity scores were defined as: 1) no limitation of daily activities; 2) limitation of daily activities but no need for supplemental oxygen; 3) supplemental oxygen via nasal cannula; 4) supplemental oxygen via facial mask; 5) non-invasive mechanical ventilation; 6) invasive mechanical ventilation; 7) multi-organ failure or extracorporeal membrane oxygenation therapy; and 8) death. | 2020-08-04 |
| 32744052 | In vitro enhanced thromboxane B2 release by polymorphonuclear leukocytes and macrophages after treatment with human recombinant interleukin 1. […] The thrombogenesis that occurs in COVID-19 includes platelet and cell aggregation with clotting abnormalities, and anti-clotting inhibitor agents are used in the prevention and therapy of thrombotic diseases. […] The treatment of innate immune cells producing IL-1 with IL-1 receptor antagonist (IL-1Ra) can avoid hemodynamic changes, septic shock and organ inflammation by carrying out a new therapeutic efficacy on COVID-19 induced by SARS-CoV-2. | 2020-08-04 |
| 32744108 | As the health knowledge construction is infused with identity and personal meanings, this reflection also shows that people from a racial group may face unfair treatment in a pandemic. | 2020-08-04 |
| 32744242 | Based on prior epidemics and financial recessions, it is likely that delayed presentation and treatment of high-grade malignancy will be associated with worse cancer outcomes. | 2020-08-04 |
| 32744511 | Prior to SARS-CoV-2 emergence, high throughput screens utilizing clinically developed drugs identified compounds with in vitro inhibitory effect on human coronaviruses that may have potential for repurposing as treatment options for COVID-19. | 2020-08-04 |
| 32744713 | The liver function recovered in all patients within one week of conventional liver protection treatment. | 2020-08-04 |
| 32744714 | Furthermore, therapy choice and timing in this challenging setting should be urgently investigated in randomized clinical trials. | 2020-08-04 |
| 32744717 | There is a great challenge for intensive care units (ICUs) in hospitals. […] The comment mainly focused on admission and discharge criteria, therapy protocol, prevention and control strategies for ICU during COVID-19 outbreak. […] The emergency strategy for ICU will be helpful for prevention and control of COVID-19 and treatment of critically ill patients with COVID-19. | 2020-08-04 |
| 32744841 | Finally, this study indicated two modifiable factors that could act as treatment targets when adapting interventions for mental health during the COVID-19 global health crisis. | 2020-08-04 |
| 32744917 | The review also highlights their advantages, disadvantages, and clinical utility for the treatment of COVID-19 patients. | 2020-08-04 |
| 32744989 | Primate models of coronavirus disease are needed to support development of therapeutics, but few models exist that recapitulate severe disease. | 2020-08-04 |
| 32745196 | Coronavirus disease 2019 (COVID-19) is a global pandemic with no licensed vaccine or specific antiviral agents for therapy. | 2020-08-04 |
| 32745217 | The results provide insight into the concerns of therapists regarding the delivery of care, and responses clarify indications for therapy and for the use of telemedicine to achieve goals during the pandemic. […] The results of this study can be used to establish guidelines for safe, effective, and efficient therapy during the pandemic. | 2020-08-04 |
| 32745304 | Studies are ongoing to decipher the risk factors and risk groups among cancer patients as well as strategies to refine treatment approaches. […] We report that patients that succumbed to COVID-19 presented with either progressive tumor disease under daratumumab treatment or were in remission under lenalidomide-dexamethasone treatment. | 2020-08-04 |
| 32745502 | For the first time, we found that zidovudine may be effective clues of treatment of COVID-19. | 2020-08-04 |
| 32745533 | The COVID-19 pandemic had a small impact on the surgical treatment of patients with head and neck oncology. | 2020-08-04 |
| 32745548 | Quercetin, with well-known pharmacokinetic and ADMET properties, can be considered as a good candidate for further optimization and development, or repositioned for COVID-19 therapeutic treatment. | 2020-08-04 |
| 32745596 | As it relates to hospitalized patients with COVID-19, such findings could prove essential in defining the role of empiric antimicrobial therapy or stewardship strategies. | 2020-08-04 |
| 32745693 | Overall, the expert panel agreed on 28 consensus statements that can be used to overcome many of the clinical and technical areas of uncertainty ranging from diagnosis to therapeutic planning and treatment during the COVID-19 pandemic. | 2020-08-04 |
| 32745811 | The immense spread of the disease in a very small period demands urgent development of therapeutic and prophylactic interventions for the treatment of SARS-CoV2 infected patients. | 2020-08-04 |
| 32745861 | In this research, a linear programming model with three objective functions is developed to minimize the total costs, the risk associated with the transportation and treatment of IMW, and the maximum amount of uncollected waste in MWGCs. […] The final results show that the model can create a balance between three considered objectives by determining the flow between centers, deciding to install two new temporary treatment centers, and allowing the network to only have uncollected waste in the first two periods in some MWGCs. | 2020-08-04 |
| 32746481 | Therefore, development of potential and effective treatment regimens (prophylactic/therapeutic) is urgently required which could resolve the issue. | 2020-08-04 |
| 32746653 | The urgent pandemic presents an unprecedented challenge to develop and identify effective medication therapy strategies to combat the COVID-19. […] Here, we summarized and evaluated the current treatment drugs and regimens, and put forward the treatment recommendations, including using the potential repurposed or experimental drugs against COVID-19, e.g. chloroquine (CQ), hydroxychloroquine (HCQ), lopinavir/ritonavir (LPV/r), remdesivir (RDV), and favipiravir (FPV). […] We also analyzed the specific drugs and vaccines against SARS-CoV-2 ongoing development and formulated the comprehensive treatment regimens based on condition of patients, diseases and drugs as well as concomitant medications. […] The recommended comprehensive medication therapy strategies have already displayed favorable effect in the fight against COVID-19. […] Research should be focused on the development of anti-SARS-CoV-2 drugs and vaccines based on high-quality clinical trial evidence, treatment guidelines and expert consensus. | 2020-08-05 |
| 32746685 | Design: The Swedish Register of Palliative Care with national coverage was used. […] Deaths in other settings (specialized palliative care wards [n = 11], in palliative home care [n = 2], or in their own homes [n = 8]) were excluded (n = 21). | 2020-08-05 |
| 32746913 | Updated versions of diagnosis and treatment guideline for novel coronavirus (COVID-19) patients have been issued, and traditional Chinese herbal medicine has been recommended as a treatment. | 2020-08-05 |
| 32746940 | The demographic, clinical characteristics and laboratory findings at admission, and treatment used in these patients were collected. | 2020-08-05 |
| 32747012 | All the patients were given antiviral and antihypertension treatment, of which 14 patients were treated with RASI and 13 patients without RASI. | 2020-08-05 |
| 32747155 | To describe the prevalence of NCDs in patients with COVID-19 in Mexico and analyze the increased risk due to comorbidities and risk factors on hospitalization, utilization of intensive care units and death. | 2020-08-05 |
| 32747201 | Delayed evaluation and/or treatment for urolithiasis during the COVID-19 pandemic provide a unique opportunity to organically reassess many well-established stone management strategies. | 2020-08-05 |
| 32747391 | The coronavirus disease 2019 (COVID-19) pandemic has elicited a swift response by the scientific community to elucidate the pathogenesis of severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2)-induced lung injury and develop effective therapeutics. | 2020-08-05 |
| 32747398 | Data were collected including medication, mode and usage of the NRS (i.e. high-flow nasal cannula (HFNC), continuous positive airway pressure (CPAP), noninvasive ventilation(NIV)), length of stay in hospital, endotracheal intubation(ETI) and deaths. | 2020-08-05 |
| 32747597 | This case highlights a broad range of vascular sequalae associated with COVID-19 and the fact that these can occur despite a combination of prophylactic and treatment dose anticoagulation. | 2020-08-05 |
| 32747703 | This paper assesses the possibility of using debt relief funds to sustain HIV treatment in sub-Saharan Africa, suppress transmission, and reach global goals to quell the epidemic by 2030. […] The cost of providing antiretroviral treatment is a huge burden on African countries. […] By analysing levels of ‘debt distress’, health expenditure per capita, and HIV antiretroviral therapy requirements in sub-Saharan African countries, the need for innovative finance with international cooperation emerges clearly. […] Relief from debt service payments could release funds for sub-Saharan African countries to support universal HIV antiretroviral treatment with sustainable results. | 2020-08-05 |
| 32747875 | Management with corticosteroids was favored in most cases, followed by antiviral medication. | 2020-08-05 |
| 32747912 | The patient had not received any treatment. | 2020-08-05 |
| 32748035 | The capacity of the virus to destroy the host cell by liberating its own DNA or RNA and replicating inside the host cell poses challenges in the development of antiviral therapeutics. […] In recent years, many new technologies have been explored for diagnosis, prevention, and treatment of viral infections. […] It includes various lipid-based, polymer-based, lipid-polymer hybrid-based, carbon-based, inorganic metal-based, surface-modified, and stimuli-sensitive nanomaterials and their application in antiviral therapeutics. […] The authors also highlight newer promising treatment approaches like nanotraps, nanorobots, nanobubbles, nanofibers, nanodiamonds, nanovaccines, and mathematical modeling for the future. | 2020-08-05 |
| 32748122 | Many aspects of care such as management of hypercoagulable state in COVID-19 patients, especially those admitted to intensive care units is challenging in the rapidly evolving pandemic of novel coronavirus disease 2019 (COVID-19). […] We seek to systematically review the available evidence regarding the anticoagulation approach to prevent venous thromboembolism (VTE) among COVID-19 patients admitted to intensive care units. […] With a high prevalence of thromboprophylaxis failure among COVID-19 patients admitted to intensive care units, individualised rather than protocolised VTE thromboprophylaxis would appear prudent at interim. | 2020-08-05 |
| 32748124 | In this review we will discuss the correlations between pathogen toxicity and endo-lysosomal cation channel function, and their potential as drug targets for infectious disease therapy. | 2020-08-05 |
| 32748212 | For cancer patients, especially those with lung cancers, their immune systems are compromised due to the disease itself as well as the treatment for cancer. […] In this study, through a literature review and data collection, we focus on the selection and consideration of antitumor treatment strategies for advanced lung cancer during the coronavirus disease 2019 (COVID-19) epidemic. | 2020-08-05 |
| 32748244 | This data includes previously used strategies against infectious disease, recent clinical trials and FDA-approved diagnostic and treatment strategies. […] Of the 98 references included in the review, the majority focused on pathogen and host targeting, symptomatic treatment and convalescent plasma utilization. […] Mixed results have been observed so far when utilising these approaches for the treatment of COVID-19 infection. […] It is concluded that the exploration of a range of diagnostic and treatment strategies for the management of COVID-19 is the need of the hour. | 2020-08-05 |
| 32748331 | However, it is not clearly delineated whether hypertension itself or associated comorbidities or antihypertensive therapy contributes to the grave prognosis of COVID-19 infections. […] Although various clinical trials are being conducted on renin- angiotensin- system inhibitor, till to date there is no standard treatment protocol approved for critically ill COVID-19 positive cases with pre-existing hypertension. […] Therefore, identification of future novel therapeutics in the form of mesenchymal stem cell either alone or in combination with pharmacological approach could be recommended for combating SARS-CoV-2 which might be dreadful to debilitating elderly people. | 2020-08-05 |
| 32748336 | Data on treatment are limited, although prophylactic anticoagulation is advised in all hospitalized patients. | 2020-08-05 |
| 32748578 | Because of its broad antiviral activity, interferon (IFN) should be evaluated as a potential therapeutic agent for treatment of coronavirus disease 2019 (COVID-19), especially while COVID-19-specific therapies are still under development. […] The patients were separated into an IFN group and a control group according to whether they received initial IFN-α2b inhalation treatment after admission. | 2020-08-05 |
| 32748740 | Once the efficacy of the drug is determined, it can be approved for of their in vitro and in vivo activity against the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), that could be interesting for rapid clinical treatment of patients. […] These promising drugs could inhibit the replication of the virus; hence, we suggest the repurposing of these compounds for thetreatment of COVID-19. | 2020-08-05 |
| 32748782 | Triggered by early outbreak signs, dissemination via community hubs and mass/social media of instructions to treat the home immediately, with monthly re-treatment thereafter, provides a simple means to engage and empower householders. | 2020-08-05 |
| 32748797 | In 4 out of 10 patients, the attempt failed due to lack of compliance of the patient, scarce pain control even with ongoing treatment and refusal by the patient to prone positioning. | 2020-08-05 |
| 32748963 | COVID-19 convalescent plasma (CCP) represents an appealing approach to the treatment of patients with infections due to SARS-CoV-2. […] Overall, six major implementation “themes” were addressed: (a) registration of individual hospitals and principal investigators with a national investigational new drug research protocol; (b) collaboration with a regional blood donor center; (c) targeted recruitment of convalesced donors; (d) IT issues related to all aspects of CCP ordering, distribution, and transfusion; (e) prioritization of patients to receive CCP; and (f) evaluation of CCP products including antibody characteristics and patient response to therapy. | 2020-08-05 |
| 32749040 | Eight patients received antifungal treatment. | 2020-08-05 |
| 32749558 | Admission rates for cardiovascular and cerebrovascular emergencies declined during the pandemic in Germany, while patients’ comorbidities and treatment allocations remained unchanged. | 2020-08-05 |
| 32749642 | It is also reassuring that the outcome of COVID-19 is unaffected by the underlying GI disorder or its treatment, though potential concerns remain in regard to the use of immunomodulatory treatments in inflammatory bowel disease (IBD) and liver transplant recipients. […] In addition, COVID-19 does not appear to impact the manifestations, course, outcome, and treatment of comorbid GI disorders, e.g. | 2020-08-05 |
| 32749697 | COVID-19 has had a significant impact on the number of patients undergoing breast cancer prevention, screening, diagnosis, and treatment. | 2020-08-05 |
| 32749808 | On 3 March 2020, the document ‘Drug treatment options for patients with COVID-19 (infections with SARS-CoV-2)’ was published on the website of the Dutch Working Party on Antibiotic Policy (StichtingWerkgroepAntibioticabeleid, SWAB). […] However, recent weeks have seen the publication of the results of various studies into the effectiveness of treatment with HCQ and CQ in patients with COVID-19. […] On the basis of these results, we conclude that there is insufficient evidence to consider HCQ and CQ as meaningful treatment options in patients with COVID-19. | 2020-08-05 |
| 32749822 | Better differentiation of suicidality can help clinical practice to offer tailored treatment and prevention. | 2020-08-05 |
| 32749826 | The treatment effects of antiviral agents, glucocorticoids, antibiotics, and intravenous immunoglobulin are controversial in patients with coronavirus disease 2019 (COVID‑19). […] This study aimed to evaluate the impact of drug therapy on the risk of death in patients with COVID‑19. | 2020-08-05 |
| 32749914 | The current management of COVID-19 is based generally on supportive therapy and treatment to prevent respiratory failure. […] The effective option of antiviral therapy and vaccination are currently under evaluation and development. […] The exit strategy for a path back to normal life is required, which should involve a multi-prong effort toward development of new treatment and a successful vaccine to protect public health worldwide and prevent future COVID-19 outbreaks. | 2020-08-05 |
| 32750000 | A majority of pregnant and nonpregnant groups received antiviral (13/17, 76% vs 25/26, 96%) and antibiotic (13/17, 76% vs 23/26, 88%) therapy. | 2020-08-05 |
| 32750006 | We also detected a low volume of pharmaceuticals that have not been approved for COVID-19 treatment. […] This cybercrime challenge is likely to continue as the pandemic progresses and more people seek access to COVID-19 testing and treatment. | 2020-08-05 |
| 32750012 | We will implement daily supportive text messaging as a way of reducing and managing anxiety and depression related to cancer diagnosis and treatment in Alberta, Canada. | 2020-08-05 |
| 32750019 | No proven effective treatment for SARS-CoV-2 exists currently. […] Early thromboprofilaxis combination with low-molecular-weight heparin and low-dose aspirin is strongly recommended with the maintenance of angiotensin-converting enzyme inhibitor (ACEI) or angiotensin-II-receptor blocker (ARB) therapy when they were prescribed earlier. | 2020-08-05 |
| 32750131 | We have published a drug-drug interaction resource to facilitate medication review for the critically ill patient. | 2020-08-05 |
| 32750187 | The emergence of the COVID-19 has caused public health problems worldwide and there is no effective pharmacological treatment for this disease. | 2020-08-05 |
| 32750201 | All patients received antiviral therapy, with arbidol and interferon being the commonest. […] Treatment should be started as early as possible, but corticosteroid and oseltamivir should be initiated with caution. | 2020-08-05 |
| 32750366 | Having studied the available publications concerning the mechanisms of damage to tissues and organs of patients with COVID-19, as well as the available treatment strategies, we propose to investigate salicyl-carnosine as a potential drug for treating COVID-19 patients. […] Thus, we propose to consider salicyl-carnosine as a potential drug for the treatment of patients with severe cases of COVID-19 infection. | 2020-08-05 |
| 32750438 | We also provide a systematic review to collate and describe all published reports of the using immunotherapies, including convalescent plasma therapy, monoclonal antibodies, cytokine therapy, mesenchymal stem cell therapy, and intravenous immunoglobulin and their important outcomes in COVID-19 patients. […] From an initial screen of 80 identified studies, 24 studies provided clinical outcome data on the use of immunotherapies for the treatment of COVID-19 patients, including convalescent plasma therapy (33 patients), monoclonal antibodies (55 patients), interferon (31 patients), mesenchymal stem cell therapy (8 patient), and immunoglobulin (63 patients). […] Except for nine severe patients who died after treatment, most patients were recovered from COVID-19 with improved clinical symptoms and laboratory assessment. […] Based on the available evidence, it seems that treatment with immunotherapy along with other standard cares could be an effective and safe approach to modulate the immune system and improvement of clinical outcomes. | 2020-08-05 |
| 32750604 | In this article, we briefly review the extensive literature supporting the effectiveness of telepsychiatry relative to in-person mental health care, and describe how payment and regulatory challenges were the primary barriers preventing more widespread adoption of this treatment modality prior to COVID-19. […] Finally, we provide clinical suggestions for optimizing telepsychiatry based on our experience, make a call for advocacy to continue the reduced insurance and regulatory restrictions affecting telepsychiatry even once this public health crisis has passed, and pose research questions that can help guide optimal utilization of telepsychiatry as mainstay or adjunct of outpatient psychiatric treatment now and in the future. | 2020-08-05 |
| 32750677 | Our recent experience of the COVID-19 pandemic has highlighted the importance of easy-to-use, quick, cheap, sensitive and selective detection of virus pathogens for the efficient monitoring and treatment of virus diseases. | 2020-08-05 |
| 32751615 | Considering the widespread use of topical ophthalmic medications (e.g., eye drops) by the general population, for various reasons (e.g., artificial tears, anti-glaucoma medications, topical antibiotics, etc.), the existence of their side effects as antiviral action should be investigated in-depth because it could possibly explain the aforementioned controversial data and represent a potential antiviral treatment for SARS-CoV-2 replication/diffusion on the ocular surface. […] Here, we discuss and elucidate the antiviral side effect of many eye drops and ophthalmic ointments commonly used for others purposes, thus showing that these secondary effects (not to be confused with the ‘adverse effects’) might be of primary importance in a number of viral infections (e.g., those for which there is no validated treatment protocol), according to a drug repurposing approach. | 2020-08-06 |
| 32751749 | Samples of untreated wastewater were collected from 33 wastewater treatment plants (WWTPs) of different sizes within the Czech Republic. | 2020-08-06 |
| 32752010 | Although antioxidant therapy has not been tested in corona virus disease-19, the consequences of antioxidant therapy in sepsis, acute respiratory distress syndrome and acute lung injury are known. | 2020-08-06 |
| 32752043 | Such biosensing devices hold the advantage of being portable for on-site testing in hospitals, airports, and hotspots, virtually without any sample treatment or complicated lab precautions. | 2020-08-06 |
| 32752270 | Given the growing body of evidence demonstrating their key contribution to pathogenesis, the viral deconjugases are now recognized as attractive targets for the design of novel antiviral therapeutics. | 2020-08-06 |
| 32752556 | Specific patient criteria for the LAHS were established, staffing was prioritized, and clinical protocols were designed to facilitate care. | 2020-08-06 |
| 32752560 | He received empiric therapy and higher level of respiratory support via a high flow nasal cannula. | 2020-08-06 |
| 32752938 | As these drugs are well tolerated, cost-effective, and widely used, our study suggests that they could potentially to be used in clinical trials for the treatment of SARS-CoV-2-infected patients. | 2020-08-06 |
| 32752944 | Until now, there is no specific drug therapy or vaccine available for the treatment of COVID-19. | 2020-08-06 |
| 32752970 | The authors systematically review the published literature on COVID-19 therapeutics, grouping candidate treatments into repurposed, adjunct, and experimental agents. | 2020-08-06 |
| 32753052 | Optimal treatment options for these patients also remains unknown at this time. | 2020-08-06 |
| 32753076 | PubMed and Google Scholar were searched from 1 January 2020 to 30 May 2020 with the following key terms: “COVID-19”, “SARS-CoV-2”, “pandemic”, “neuro-COVID”, “stroke-COVID”, “epilepsy-COVID”, “COVID-encephalopathy”, “SARS-CoV-2-encephalitis”, “SARS-CoV-2-rhabdomyolysis”, “COVID-demyelinating disease”, “neurological manifestations”, “psychosocial manifestations”, “treatment recommendations”, “COVID-19 and therapeutic changes”, “psychiatry”, “marginalised”, “telemedicine”, “mental health”, “quarantine”, “infodemic” and “social media”. | 2020-08-06 |
| 32753141 | Twelve-lead electrocardiograms were recorded before treatment, at day 3, at day 5, and at discharge. […] Treatment discontinuation was decided in 6 patients (12%), leading to QTc normalization in 5 of them. […] Our report confirms that a short duration treatment with HCQ + AZ modifies the QTc interval. […] The treatment had to be discontinued for QTc modifications in 12% of patients. | 2020-08-06 |
| 32753143 | The purpose of this cross-sectional analysis of telestroke activations in the 30 days before and after the declaration of the COVID-19 pandemic is to describe the difference in case volumes of telestroke activations, the characteristics of patients, and treatment recommendations between the 2 time frames. […] The percentage of patients for whom we recommended urgent stroke treatment with intravenous alteplase, mechanical thrombectomy, or both decreased from 44.4% (28 of 63) to 33.3% (11 of 33). […] The reasons for the sunstantial decrease in telestroke activations and urgent stroke treatment recommendations are likely multifactorial but nevertheless underscore the importance of continued public health measures to encourage patients and families to seek emergency medical care at the time of symptom onset. | 2020-08-06 |
| 32753145 | In this article, we explore the possible anti-inflammatory effects of estrogen and testosterone and the anabolic effect of testosterone, with particular attention to the potential therapeutic role of hormone replacement therapy in older men and women with COVID-19. | 2020-08-06 |
| 32753148 | Medical therapy, during pregnancy and breastfeeding, relies on medications with proven safety, but safety data are often missing for medications in the early stages of clinical trials. […] We summarize guidelines for medical/obstetric care and outline future directions for optimization of treatment and preventive strategies for pregnant patients with COVID-19 with the understanding that relevant data are limited and rapidly changing. | 2020-08-06 |
| 32753243 | We evaluated published information in peer-reviewed journals between January 1, 2020, and April 24, 2020, with available data on acute kidney injury (AKI), renal replacement therapy (RRT), intensive care unit (ICU) stay, and death and compared clinical outcomes in KTR vs nontransplant recipients with COVID-19. | 2020-08-06 |
| 32753340 | Electroconvulsive therapy (ECT) is an essential psychiatric service with an important role in treating older adults with severe or treatment-resistant depression. […] The 600-pulses aiTBS treatment protocol reported here warrants further study and evaluation, but may be a potential option in cases where older adults with severe depressive symptoms cannot access ECT during the COVID-19 pandemic. | 2020-08-06 |
| 32753362 | This study sought to estimate the impact of cessation of treatment on individual prognosis and US population live birth rates. […] The effect of a 1-month, 3-month and 6-month shutdown in IVF treatment was calculated as the effect of the equivalent increase in a woman’s age, stratified by age group. […] The study demonstrated that the discontinuation of fertility treatment for even 1 month in the USA could result in 369 fewer women having a live birth, due to the increase in patients’ age during the shutdown. | 2020-08-06 |
| 32753375 | A short-cut review of the available medical literature was carried out to establish whether remdesivir was an effective treatment for patients with confirmed COVID-19 infection. | 2020-08-06 |
| 32753393 | In response, clinical staff and resources have been redeployed to the areas of greatest need, that is, intensive care units and emergency rooms (ER), to reinforce front-line manpower. | 2020-08-06 |
| 32753516 | Review of the records revealed 138 (92%) patients had pulmonary infiltrates on chest radiography, and 146 (97%) required oxygen therapy. | 2020-08-06 |
| 32753638 | Individuals with spinal cord injury (SCI) develop systemic physiological changes that could increase the risk of severe evolution of coronavirus disease 2019 (COVID-19) and result in atypical clinical features of COVID-19 with possible delay in both diagnosis and treatment. […] Nevertheless, no significant differences in clinical expression of COVID-19 and treatment strategies were observed between the two groups. | 2020-08-06 |
| 32753646 | As no approved therapeutics exists to treat COVID-19, the disease associated to SARS-Cov-2, there is an urgent need to propose molecules that could quickly enter into clinics. | 2020-08-06 |
| 32753794 | Face shields can be made more effective in different triaging and treatment situations by varying the device setup. | 2020-08-06 |
| 32753816 | We cannot be callous about treatment of non-COVID-19-related patients. | 2020-08-06 |
| 32753842 | There have been studies on the COVID-19 to find a certain treatment, but yet, there is no certain cure. […] Therefore, we propose a way of washing out (by plasmapheresis) the possible antibodies against the spike protein of the virus out of patients’ plasma to stop the antibody-dependent enhancement (ADE)-mediated infection of the immune system cells at the first phase of the treatment and simultaneous use of the anti-ACE2 with anti-FcγRII monoclonal antibodies at the second phase. | 2020-08-06 |
| 32753986 | Therefore, limiting people’s psychological damage demands both medium- and long-term policy strategies, which include mapping the rates of stress and anxiety for effective psychological treatment allocation and establishing innovative online methods of heightening people’s mental wellbeing. | 2020-08-06 |
| 32754000 | SARS-CoV-2 cases and deaths in children are minimal compared to adults, but the pandemic impacts other ‘essential’ aspects of children’s health including child development and the associated areas of paediatric behaviour, mental health, and maltreatment. […] Alongside the management of severe SARS-CoV-2 cases in emergency rooms and intensive care units, continuing to care for children with developmental disabilities must also be concurrently championed as ‘essential’ during this crisis. | 2020-08-06 |
| 32754003 | However, some others need special and emergency treatment to get rid of this widespread disease. […] Till now, there are numbers of proposed novel compounds as well as standards therapeutics agent existed for other conditions seems to have efficacy against the 2019-nCoV. […] The main purpose of this paper is to review typical and ongoing treatments for coronavirus disease including home remedies, herbal medicine, chemical drugs, plasma therapy, and also vaccinies. […] We hope that this work could pave the way for researchers to develop faster and more reliable methods for earlier treatment of patients and rescue more people. | 2020-08-06 |
| 32754005 | We then created machine learning (ML) models that could analyze the collected physiologic data to determine if the ventilator was delivering potentially harmful therapy and if a deadly respiratory condition, acute respiratory distress syndrome (ARDS), was present. | 2020-08-06 |
| 32754036 | The sudden outbreak of the COVID-19 pandemic, caused by SARS-CoV-2, has put the whole world into a difficult situation, asking for the immediate development of therapeutics and vaccines against the disease. | 2020-08-06 |
| 32754041 | Although COVID-19 patients are administered glucocorticoid therapy to treat the excessive immune response to severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection, the efficacy of this form of therapy is unclear. […] Cellular therapy, along with organ support systems such as oxygen therapy, artificial ventilation, extra corporeal membrane oxygenation and dialysis, as well as antiviral therapy, are required. […] The application of pharmacological chaperone therapy to treat COVID-19 patients is additionally discussed. | 2020-08-06 |
| 32754102 | Monitoring and timely treatment of these conditions is needed. | 2020-08-06 |
| 32754119 | Clinical information, laboratory findings, complications, treatment regimens, and mortality status were collected. | 2020-08-06 |
| 32754134 | Here, several pharyngeal samples with COPD were collected to enrich viral particles using an optimized method (M3), which involved M1 with centrifugation, filtration, and concentration, M2 (magnetic beads) combined with mixed nuclease digestion, and M4 with no pretreatment as a control. | 2020-08-06 |
| 32754159 | In this article, we present an overview of the cytokine storm and its implications in COVID-19 settings and identify potential pathways or biomarkers that could be targeted for therapy. | 2020-08-06 |
| 32754224 | The therapeutic benefits of Cold‒Damp Plague Formula (CDPF) against COVID-19, which was used to treat “cold‒dampness stagnation in the lung” in Trial Versions 6 and 7 of the “Diagnosis and Treatment Protocol for COVID-19”, have been demonstrated, but the effective components and their mechanism of action remain unclear. […] In this study, a network pharmacology approach was employed, including drug-likeness evaluation, oral bioavailability prediction, protein‒protein interaction (PPI) network construction and analysis, Gene Ontology (GO) terms, and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway annotation, and virtual docking, to predict the bioactive components, potential targets, and molecular mechanism of CDPF for COVID-19 treatment. […] Subsequently, the candidate targets of the active compounds were compared to those relevant to COVID-19, to identify the potential targets of CDPF for COVID-19 treatment. […] This study revealed the active ingredients and potential molecular mechanism by which CDPF treatment is effective against COVID-19, and provides a reference basis for the wider application and further mechanistic investigations of CDPF in the fight against COVID-19. | 2020-08-06 |
| 32754225 | This is in order that they can be sustained for an extended period of time, until COVID-19 can be controlled or vaccine and treatment options become available. | 2020-08-06 |
| 32754234 | Conclusion The study demonstrated a direct impact of the COVID-19 pandemic on the clinical practice of specialties related to the treatment of patients with diseases of the head and neck region already in the beginning of the illness management in Brazil. | 2020-08-06 |
| 32754248 | Objective The present review summarizes currently published evidence of Covid-19 epidemiology, clinical characteristics, treatment and prevention. […] However, no current treatments (April 27, 2020) have been proven to be the key to success in the treatment of patients with COVID-19. | 2020-08-06 |
| 32754319 | National and international authorities and societies have recently published important cancer treatment recommendations in order to propose extra measures that should be taken during the COVID-19 pandemic, such as prioritisation of intend-to-cure treatments and younger patients, omission of non-urgent cases, and reduction of personnel present. | 2020-08-06 |
| 32754377 | There are no guidelines, based on randomized controlled trials, for the treatment of COVID-19 patients. […] The treatment is based on antiviral drugs, invasive and non-invasive ventilation supports, and anticoagulant therapy. […] This is a pictorial essay covering the multiple adverse events encountered during the treatment of COVID-19 patients in an area with a high pandemic incidence. […] Adverse events are defined as unexpected events following treatment for the infection. […] The cases described would be useful in aiding early diagnosis, limiting and improving the management of serious complications for patients, and allowing rapid and appropriate treatment. | 2020-08-06 |
| 32754388 | With the rapidly increasing number of positive cases and deaths, there is a dire need for effective treatment. […] An urgent unmet need led to the planning and opening of multiple drug development trials for treatment and vaccine development. […] We have tabulated available data on various clinical trials testing various aspects of COVID-19 therapeutics. | 2020-08-06 |
| 32754408 | An urgent unmet need led to the planning and opening of multiple drug development trials for treatment and vaccine development. | 2020-08-06 |
| 32754447 | Cancer patients are a population at high risk of contracting COVID-19 and, also of developing severe complications due to the infection, which is especially true when they are undergoing immunosuppressive treatment. […] In this context, we have evaluated the psychological status of onco-hematological outpatients receiving infusion and not deferrable anti-neoplastic treatment for lymphoproliferative neoplasms, with the aim of both measuring the levels of post-traumatic symptoms, depression, and anxiety during the pandemic and also of investigating the perception of risk of potential nosocomial infection. | 2020-08-06 |
| 32754570 | Currently, no approved treatment is available for SARS-CoV-2 given the lack of evidence. […] The results from preliminary clinical trials have been mixed as far as improvement in the clinical condition and reduction in the duration of treatment are concerned. […] This review focuses on recent advancements in the field of development of diagnostic tests, vaccines, and treatment approaches for COVID-19. | 2020-08-06 |
| 32754600 | Through associating infection symptoms with the transmission routes of virus and the patient course of the disease, we expect to provide guidelines for clinical diagnosis and the basis for suppressing the spread of the virus and antiviral treatment. | 2020-08-06 |
| 32754730 | By presenting 3 such cases, we highlight that pneumomediastinum can complicate the course of a severe coronavirus disease 2019 infection but emphasize that conservative management is the first-line method of treatment, with gradual resorption of the air from the tissues. | 2020-08-06 |
| 32754756 | In addition, as of 13 April, the case fatality rate of COVID-19 in Korea was 2.1%, suggesting a positive effect of the targeted treatment policy for severe patients and medical resources. | 2020-08-06 |
| 32755094 | In this review, we summarize the virus immune response steps, underlying the relevance of introducing the measurement of plasma cytokine levels and of circulating lymphocyte subsets in clinical practice for the follow-up of critically ill COVID-19 patients and support new therapy. | 2020-08-06 |
| 32755117 | In recent years, high flow nasal cannula (HFNC) is a respiratory support system that has become prominent in the treatment of respiratory failure. […] So, HFNC treatment should be carried out in a negative pressure room; when it is not possible, devices should be undertaken in a single room. | 2020-08-06 |
| 32755231 | To date, there is no approved vaccine or specific therapy against COVID-19, but many trials are ongoing with some of them showing promising results. | 2020-08-07 |
| 32755287 | Conclusions and Relevance: Our findings offer guidance for a wide spectrum of clinicians to early identify severe COVID-19 patients, transport to specialised centres, and initiate appropriate treatment. […] These findings provide guidance to health professionals with early identification of severe COVID-19 patients, transportation to specialised care and initiate appropriate supportive treatment. | 2020-08-07 |
| 32755302 | This highlights the importance of understanding the SARS-CoV-2 mechanisms of actions and the urgent need of prospecting for new or alternative treatment options. | 2020-08-07 |
| 32755395 | Thus, a combined intervention of AMPK and MDM2 in the pulmonary endothelium might be therapeutically effective in PH treatment. | 2020-08-07 |
| 32755466 | Importantly, IGF-1 supplementation or anti-IL-6 treatment rescued the arrhythmia substrates induced by failing hMSCs. […] Importantly, therapy inhibiting (anti-IL-6) or mimicking (IGF-1) the cardiac hMSC secretome can rescue arrhythmia substrates. | 2020-08-07 |
| 32755472 | Psychiatric services that provide acute inpatient care have to respond to the challenges brought about by the COVID-19 pandemic to consistently deliver high standards of treatment to patients and ensure the safety of staff. | 2020-08-07 |
| 32755479 | Testing patients with cancer for COVID-19 via reverse transcriptase polymerase chain reaction before systemic treatment was not routinely implemented: 58% reported no routine testing, 39% performed testing in selected patients, and 3% performed systematic testing in all patients. […] The most significant factors influencing an oncologist’s decision making regarding choice of systemic therapy included patient age and comorbidities (81% and 92%, respectively). […] Although treatment in neoadjuvant, adjuvant, and first-line metastatic disease was less affected, most of the participants stated that they would be more hesitant to recommend second- or third-line therapies in metastatic disease. | 2020-08-07 |
| 32755538 | In this context, a race against the clock is launched in order to develop a treatment to stop the pandemic as soon as possible. | 2020-08-07 |
| 32755598 | These findings suggest a potential application of FRIL for the prevention and/or treatment of influenza and COVID-19. | 2020-08-07 |
| 32755653 | The present study showed a significant decrease in admission to ICU over time, which was probably related to multiple factors, including a better indication of pulmonary CT-scan, oxygen therapy, and a suitable prescription of anti-infective agents. | 2020-08-07 |
| 32755673 | Researchers worldwide are pacing with high efforts to counter the spread of this virus and to design effective vaccines and therapeutics/drugs. | 2020-08-07 |
| 32755836 | Till date, there is no approved medicine/treatment to cure COVID-19, whereas, vaccine development efforts are going on high priority. | 2020-08-07 |
| 32755844 | Thus, a web-based survey was conducted to decipher the approach of Indian doctors to the various options for treatment of COVID-19. | 2020-08-07 |
| 32755848 | Tuberculosis (TB) still continues to be endemic in various regions of the world, including in India and needs surveillance, clinical assessment, testing, contact tracing, confirmation of diagnosis with supervised or in-supervised treatment regimens for an effective eradication. […] COVID-19 pandemic has had a significant impact in the delivery of various tuberculosis prevention, surveillance, and treatment programmes. | 2020-08-07 |
| 32756065 | Considering the significant respiratory sequelae reported following COVID-19, proper respiratory and physical therapy programs should be promptly made available. | 2020-08-07 |
| 32756089 | This systematic review protocol is designed to provide evidence regarding the effects and safety of Chinese traditional medicine injections on patients with COVID-19, such evidence may be useful and important for clinical treatment decisions. | 2020-08-07 |
| 32756114 | At present, there is still a lack of reevaluation of systematic evaluation of traditional Chinese medicine treatment IPF. […] Therefore, a systematic re-evaluation of the systematic evaluation of traditional Chinese medicine in the treatment of pulmonary fibrosis may help to understand the effective treatment scheme of traditional Chinese medicine in the treatment of pulmonary fibrosis and provide more reliable evidence for the first-line clinicians to treat novel coronavirus. […] We will consider SRs and meta-analysis of Traditional Chinese Medicine for the Treatment of pulmonary fibrosis. […] We expect to obtain reliable evidence from systematic analysis of traditional Chinese medicine treatment of pulmonary fibrosis in an available and useful document. | 2020-08-07 |
| 32756149 | Therefore, investigating the potential of hUCMSCs to the treatment of COVID-19 critically ill patients is necessary. […] According to the guideline for the diagnosis and treatment of 2019 novel coronavirus infected pneumonia (Trial 4th Edition), COVID-19 was diagnosed, based on the real-time RT-PCR test of SARS-CoV-2. […] After regular treatment for 12 days, the inflammation symptom of the patient was still very severe and the potential side effects of corticosteroid were observed. | 2020-08-07 |
| 32756178 | The original report also showed that the mortality rate of COVID-19 in breast cancer patients is more dependent on comorbidities than previous radiation therapy or current anti-cancer therapy. […] This study will provide comprehensive evidence for medical staff to adopt effective treatment strategies for breast cancer patients during the COVID-19 pandemic. | 2020-08-07 |
| 32756188 | Other causes of syncope such as adrenal insufficiency secondary to corticosteroids treatment, cardiac rhythm disorders, neurological impairment, dehydration, vasoactive medication, malignancies, pulmonary hypertension and coughing were excluded. […] The treatment of SARS-CoV-2 infection was performed following the local and national guidelines. | 2020-08-07 |
| 32756215 | The patient was treated with a moderate dose of intravenous corticosteroids and high-flow nasal cannula oxygen therapy. | 2020-08-07 |
| 32756271 | Emergency surgery is still a priority, but in case of spinal tumors it should be better defined which conditions require emergency treatment. […] Most complex surgery, like en bloc resection, associated with high morbidity and mortality rate for the treatment of low grade malignancy like chordoma or chondrosarcomas, if intensive care unit availability is reduced, can be best delayed some weeks, as not impacting on prognosis, due to the slow growth rate of these conditions. […] Even more than during normal times, a multidisciplinary approach is mandatory to share the decision to modify a treatment strategy. | 2020-08-07 |
| 32756382 | Of those on long-term NCD medication, 10% reported having less than one week’s supply of medication. | 2020-08-07 |
| 32756480 | The most promising therapy to date is remdesivir, which is US Food and Drug Administration (FDA) approved for emergency use in adults and children hospitalized with severe suspected or laboratory-confirmed COVID-19. | 2020-08-07 |
| 32756535 | Noninvasive respiratory support (NRS) such as noninvasive ventilation (NIV) and high flow nasal therapy (HFNT) have been used in the treatment of acute hypoxemic respiratory failure (AHRF) related to the coronavirus disease (COVID-19) and other viral infections. […] Use of NRS and treatment failure in the context of COVID-19 and viral infection associated-AHRF, varied widely. | 2020-08-07 |
| 32756614 | The results demonstrate that aptamers are powerful molecular tools for virus detection, diagnosis, and antiviral therapy. | 2020-08-07 |
| 32756734 | Furthermore, pre-existing neurological conditions may require special treatment and may be associated with worse outcomes. […] After diagnosis, neurologists were involved in the treatment. | 2020-08-07 |
| 32756857 | Although the 2019 severe acute respiratory syndrome coronavirus 2 infection (SARS-CoV-2, COVID-19) pandemic poses new challenges to the healthcare system to provide support for thousands of patients, there is special concern about common medical emergencies, such as stroke, that will continue to occur and will require adequate treatment. […] The allocation of both material and human resources to fight the pandemic cannot overshadow the care for acute stroke, a time-sensitive emergency that with an inefficient treatment will further increase mortality and long-term disability. | 2020-08-07 |
| 32757246 | ACEI/ARB therapy might be associated with the reduced inflammatory factor (interleukin-6) and elevated immune cells counts (CD3, CD8). […] Meta-analysis showed no significant increase in the risk of COVID-19 infection (odds ratio [OR]: 0.95, 95%CI: 0.89-1.05) in patients receiving ACEI/ARB therapy, and ACEI/ARB therapy was associated with a decreased risk of severe COVID-19 (OR: 0.75, 95%CI: 0.59-0.96) and mortality (OR: 0.52, 95%CI: 0.35-0.79). […] Subgroup analyses showed among the general population, ACEI/ARB therapy was associated with reduced severe COVID-19 infection (OR: 0.79, 95%CI: 0.60-1.05) and all-cause mortality (OR: 0.31, 95%CI: 0.13-0.75), and COVID-19 infection (OR: 0.85, 95% CI: 0.66-1.08) were not increased. […] On the basis of the available evidence, ACEI/ARB therapy should be continued in patients who are at risk for, or have COVID-19, either in general population or hypertension patients. | 2020-08-07 |
| 32757278 | The aim of this study was to evaluate the applicability of bedside ultrasonography for the diagnosis of deep venous thrombosis (DVT) in patients infected with corona virus disease 2019 (COVID-19) with and without treatment with low molecular weight heparin (LMWH). | 2020-08-07 |
| 32757345 | Recently, there exist no effective treatment procedures that can control this disease [1]. | 2020-08-07 |
| 32757420 | Uncertainties remain concerning the pathophysiology, epidemiology, and potential therapeutics for COVID-19. | 2020-08-07 |
| 32757497 | There are no proven therapeutics for Coronavirus disease 2019 (COVID-19) pneumonia outbreak. | 2020-08-07 |
| 32757499 | Depending on the epidemiological situation, each medical institution should systematically share the responsibility for patient screening, disposition and treatment according to clinical severity. | 2020-08-07 |
| 32757500 | A novel antiviral agent, remdesivir (RDV), is a promising candidate treatment for coronavirus disease 2019 (COVID-19) in the absence of any proven therapy. | 2020-08-07 |
| 32757544 | The national and international health agencies, including the Centers for Disease Control and Prevention (CDC) and the WHO, have provided guidelines for prevention and treatment suggestions. | 2020-08-07 |
| 32757745 | However, it is imperative to develop the regimens for more accurate diagnostic tools, preventive care and effective therapy. […] Our critical and comprehensive review presents emerging avenues of molecular diagnostics as well as therapeutics translated into clinical approaches. […] This manuscript critically reviews the rampant future of AuNPs in the diagnosis and treatment of the most important diseases, such as cancer and viruses of respiratory system. | 2020-08-08 |
| 32757760 | In patients with psoriasis, inhibition of select pro-inflammatory cytokines through the use of biologic agents has been shown to be an effective treatment option. […] Currently, there is insufficient evidence to discontinue biologic therapy in patients with psoriasis who have not tested positive for COVID-19. […] The decision to pause biologic therapy should be considered on a case-by-case basis in patients in higher risk populations, and should take into account individual risk and benefit. […] Until more is known about the impact of biologic therapy on COVID-19 outcomes, we recommend patients with psoriasis who test positive for COVID-19 be instructed to discontinue or postpone biologic treatment until they have recovered from infection. | 2020-08-08 |
| 32757995 | All 4 patients achieved significant partial olfactory recovery by one week after treatment with subjective ratings of 40% to 85% of normal (mean 60%) and complete olfaction recovery after 2 to 3 weeks in all 4 patients. | 2020-08-08 |
| 32758037 | In this review, it was aimed to discuss that Covidien-19 against antiviral drugs used in the struggle across the globe and plasma treatment options about the current state of knowledge and Turkey algorithm by comparing the therapeutic treatment options. | 2020-08-08 |
| 32758273 | Focusing on epigenetic therapies reaching clinical trials, clinically approved epigenetic-targeted agents, and combination therapy of antivirals and epigenetic drugs is currently considered an effective and valuable approach for viral replication and inflammatory overdrive control. | 2020-08-08 |
| 32758298 | All patients will receive standard-of-care treatment according to the current institutional protocols. […] After 3 days of treatment, 3 intensive care physicians will evaluate the participant and decide whether or not to complete the treatment based on their clinical assessment: • If objective or subjective signs of improvement or no worsening of the general clinical condition, respiratory failure, inflammatory state or multi-organ failure are observed, the participant will continue the treatment until completion. […] • If an adverse effect or clinical impairment is observed that is objectively or subjectively attributable to the study drug the treatment will be stopped. | 2020-08-08 |
| 32758318 | In response to the COVID-19 pandemic, in addition to actively finding effective treatment drugs and developing vaccines, it is more important to identify the source of infection at the community level as soon as possible to block the transmission path of the virus to prevent the spread of the pandemic. | 2020-08-08 |
| 32758336 | BCG is a multi-face vaccine that has been used extensively in protection from tuberculosis (TB) and leprosy and has been repositioned for treatment of bladder cancer, diabetes and multiple sclerosis. | 2020-08-08 |
| 32758363 | It has also impacted different aspects of caring for people with kidney disease, including those with acute kidney injury (AKI), chronic kidney disease (CKD), those requiring kidney replacement therapy (KRT), and those with a kidney transplant. | 2020-08-08 |
| 32758569 | It is observed that Eriodictyol binds to almost all selected target proteins with good binding energy, suggesting its importance in treatment of COVID 19. […] Molecular interactions of Ritonavir, Lopinavir and Remdesivir against SARS-CoV-2 proteins enhanced their potential as a candidate drug for treatment of COVID-19. | 2020-08-08 |
| 32758625 | This review highlights the current scenario of coronavirus disease in pre-existing diabetic patients, epidemiology, molecular perception, investigations, treatment and management of COVID-19 disease in patients with pre-existing diabetes. | 2020-08-08 |
| 32758659 | We collected demographic, clinical, laboratory, treatment and complications data. […] During hospitalization, 1255 (31.5%) of 3979 patients developed acute respiratory distress syndrome, 736 (18.5%) of 3988 were admitted to intensive care units and 619 (15.5%) of 3992 underwent mechanical ventilation. | 2020-08-08 |
| 32758689 | Antiviral effects of Novaferon in COVID-19 patients with treatment of Novaferon, Novaferon plus Lopinavir/Ritonavir, or Lopinavir/Ritonavir were evaluated. […] The primary endpoint was the SARS-CoV-2 clearance rates on day six of treatment, and the secondary endpoint was the time to SARS-CoV-2 clearance. | 2020-08-08 |
| 32758747 | This paper presents an updated and comprehensive review on the different methods used for detection and quantification of viruses in wastewater treatment systems. […] Recent studies have mostly focused on determining the abundance and diversity of viruses in wastewater influents, in samples from primary, secondary, and tertiary treatment stages, and in final effluents. […] A summary and a detailed comparison of the pre-treatment methods that have been utilized for wastewater and sludge samples are also presented. […] The role of metagenomics or sequencing analysis in monitoring wastewater systems to predict disease outbreaks, to conduct public health surveillance, to assess the efficiency of existing treatment systems in virus removal, and to re-evaluate current regulations regarding pathogenic viruses in wastewater is discussed in this paper. | 2020-08-08 |
| 32758871 | SARS-CoV-2, the agent of COVID-19, shares a lineage with SARS-CoV-1, and a common fatal pulmonary profile but with striking differences in presentation, clinical course, and response to treatment. […] Our proposed mechanism of lung injury provides an explanation for early hypoxia without reduction in lung compliance and suggests a need for revision of treatment protocols to address vasoconstriction, thromboprophylaxis, and to minimize additional small airways and alveolar trauma via ventilation choice. | 2020-08-08 |
| 32758873 | Repurposed EDTA delivery to respiratory tissues at an initial target dose of 2.4 mg per aerosol treatment is readily achievable with standard nebulizer and mechanical ventilator equipment. […] EDTA warrants further investigation as a potential treatment for SARS-CoV-2/COVID-19 in consideration of the new calcium requirements for virus infection and the regular presence of EDTA excipients in common asthma medications such as Metaproterenol. | 2020-08-08 |
| 32758881 | Although vaccines and antiviral agents are the main focus of therapy, here we present a plausible hypothesis to leverage our understanding of neuroimmunomodulation to intervene in the pathophysiology of the disease to prevent death. | 2020-08-08 |
| 32758889 | The use of drugs that inhibit IL-6 biological activity has been proposed as a treatment for patients with Coronavirus Disease 2019 (COVID-19). | 2020-08-08 |
| 32758903 | In the attempt to decipher the enigma of SARS-CoV-2 infectivology, the hypothesis should be tested whether the population of subjects who succumbed to Covid-19 may have developed a compromised immunity at sub-clinical levels and have become more susceptible to fatal consequences from SARS-Cov-2 infection due to statin therapy. | 2020-08-08 |
| 32758904 | Consequently we hypothesize that N-acetylcysteine along with the conventional treatment may be treated as a potential therapeutic solution in cases of COVID-19 patients. | 2020-08-08 |
| 32758945 | Municipal wastewater seeded with a human coronavirus (CoV) surrogate, murine hepatitis virus (MHV), was used to test the efficiency of seven wastewater virus concentration methods: (A-C) adsorption-extraction with three different pre-treatment options, (D-E) centrifugal filter device methods with two different devices, (F) polyethylene glycol (PEG 8000) precipitation, and (G) ultracentrifugation. […] The most efficient methods were adsorption-extraction methods with MgCl2 pre-treatment (Method C), and without pre-treatment (Method B). […] Our results suggest that absorption-extraction methods with minimal or without pre-treatment can provide suitably rapid, cost-effective and relatively straightforward recovery of enveloped viruses in wastewater. | 2020-08-08 |
| 32759013 | Tachyphylaxis to the current therapy, inhaled nitric oxide (iNO), is also common. […] We therefore hypothesise that folic acid, 5 mg or greater, is a useful therapeutic option for pulmonary hypertension and/or refractory severe hypoxaemia, in patients with severe COVID-19 associated pneumonia in whom NO therapy is considered, with a very low risk of adverse effects. | 2020-08-08 |
| 32759092 | Antiseizure medication weaning plans and changes in vagal nerve stimulator settings were halted. | 2020-08-08 |
| 32759101 | We explored the effects of long-term treatment by calcium channel blockers on the outcomes of COVID-19 infection in patients with high blood pressure during in-patient hospital stays using two sources of information: data available strictly from structured electronic health records (EHRs) and data available through structured EHRs and text mining. […] When that information was used to supplement existing structured data, the sample size could be increased sufficiently to see treatment effects that were not previously statistically detectable. | 2020-08-08 |
| 32759176 | Given the lack of currently available effective treatment for COVID-19, it has re-emerged as a potential therapeutic option. […] While convalescent plasma therapy is proven safe and historical evidence suggests it may be effective, it has not been proven to be of benefit in acute COVID-19. […] Many clinical trials are currently underway to evaluate convalescent plasma for treatment of COVID-19, but the vast majority of plasma is currently administered as compassionate use of an experimental therapy through an expanded access program. | 2020-08-08 |
| 32759228 | The French military medical supply chain supported all military medical treatment facilities in France as well as overseas, coping with a growing shortage of medical equipment. | 2020-08-08 |
| 32759247 | Community-based and palliative care specialist physicians who visit residents in LTC facilities play an important role in supportive end-of-life care. […] The objective of this study was to explore barriers and facilitators to optimal supportive end-of-life palliative care in LTC through the experiences and perceptions of community-based and palliative specialist physicians who visit LTC facilities. […] Residential long-term care. 23 physicians who visit LTC facilities from across Alberta, Canada, including both in urban and rural settings of whom 18 were community-based physicians and 5 were specialist palliative care physicians. […] Capability barriers include lack of symptom assessment tools, as well as palliative care knowledge, training and mentorship. […] Findings reveal that validating families’ concerns, having appropriate symptom assessment tools, providing mentorship in palliative care and adapting the physical and social environment to support dying and grieving with dignity facilitates supportive, end-of-life care within LTC. | 2020-08-08 |
| 32759457 | Problematic is not just the limitation of physical spaces in intensive care units, but also the availability of trained personnel. | 2020-08-08 |
| 32759459 | We report the case of an elderly female where the sum of such factors - together with massive findings in the computed tomography of the lung - led us to a therapy with hydroxychloroquine as a compassionate use. | 2020-08-08 |
| 32759504 | Treatment of control neutrophils with COVID-19 platelet-rich plasma generated TF-bearing NETs that induced thrombotic activity of HAECs. | 2020-08-08 |
| 32759887 | The shortage of specific anti-viral treatment and vaccines remains a huge challenge. | 2020-08-08 |
| 32759894 | We searched for randomized trials evaluating the effect, in patients with COVID-19, of vitamin C versus placebo or no treatment. […] We did not find any studies that met our inclusion criteria, and hence there is no evidence to support or refute the use of vitamin C in the treatment of patients with COVID-19. | 2020-08-08 |
| 32760195 | This review summarizes the expert consensus on the mental health treatment and services for severe psychiatric disorders during the COVID-19 outbreak developed by the Chinese Society of Psychiatry and other academic associations. […] The Expert Recommendations on Internet and Telehealth in Psychiatry during Major Public Health Crises (COVID-19) describe the assessment and treatment issues of internet-based mental health services during the COVID-19 outbreak. | 2020-08-08 |
| 32760206 | COVID-19 is a public health emergency that has rapidly spread to over 200 countries and regions, and no effective treatment has been established to date. […] Based on the novelty and recent emergence of COVID-19, no effective treatment regimen has been identified, thus prompting clinicians to engage in drug repurposing to address the immediate therapeutic need. | 2020-08-08 |
| 32760350 | We collected and analyzed their data, including demographic data, history of comorbidity, clinical symptoms, laboratory tests, chest computed tomography (CT) images, treatment options, and survival. | 2020-08-08 |
| 32760407 | While most infected individuals only experience mild symptoms or may even be asymptomatic, some patients rapidly progress to severe acute respiratory failure with substantial mortality, making it imperative to develop an efficient treatment for severe SARS-CoV-2 pneumonia alongside supportive care. […] So far, the optimal treatment strategy for severe COVID-19 remains unknown. […] In this review, we aim to highlight the known mechanisms of immunomodulatory effects of high-dose IVIg therapy, the immunopathological hypothesis of viral pneumonia, and the clinical evidence of IVIg therapy in viral pneumonia. […] We then make cautious therapeutic inferences about high-dose IVIg therapy in treating severe COVID-19. […] These inferences may provide relevant and useful insights in order to aid treatment for COVID-19. | 2020-08-08 |
| 32760409 | Ultimately, we hypothesize that the use of oral β-glucan in a prophylactic setting could be an effective way to boost immune responses and abrogate symptoms in COVID-19, though clinical trials are necessary to confirm the efficacy of this treatment and to further examine differential effects of β-glucan’s from various sources. | 2020-08-08 |
| 32760619 | There was minimal improvement in her vestibular symptoms with the recommended COVID-19 treatment as of March 2020 (hydroxychloroquine and azithromycin) and symptomatic management. | 2020-08-08 |
| 32760732 | The global pandemic of coronavirus disease 2019 (COVID-19) has resulted in an increased demand for testing, diagnosis, and treatment. | 2020-08-08 |
| 32760733 | A combined treatment with colchicine, tocilizumab, high dose immunoglobulins, and methylprednisolone allowed to control the inflammatory process and to limit the development of coronary aneurysm. | 2020-08-08 |
| 32760752 | Demographic, clinical, radiological, laboratory, and treatment data were reviewed. | 2020-08-08 |
| 32760887 | This clinical practice guideline includes pulmonary rehabilitation (PR) recommendations for adult COVID-19 patients and has been developed in the light of the guidelines on the diagnosis and treatment of COVID-19 provided by the World Health Organization and Republic of Turkey, Ministry of Health, recently published scientific literature, and PR recommendations for COVID-19 regarding basic principles of PR. | 2020-08-08 |
| 32761102 | The physicians identified 8 oncology-specific, COVID-19-related scenarios in which communication might be challenging: (1) worse outcomes from COVID-19, (2) delay in cancer screening, (3) delay in diagnostic workup, (4) delay in initiation of treatment, (5) offer of nonstandard treatment, (6) treatment breaks, (7) delay in follow-up imaging or care, and (8) inability to be admitted into the hospital for management. | 2020-08-08 |
| 32761149 | Fourth, proactive safeguards must be implemented to protect vulnerable individuals, or disparities in cancer treatment and outcomes will only widen further. | 2020-08-08 |
| 32761196 | Rapid discharge (length of stay = 13,8 ± 6,9) with remission of symptoms (BPRS = 27,5 ± 3,1) and satisfactory insight were possible after relatively low-dose antipsychotic treatment (Olanzapine-equivalents = 10,6 ± 5,4 mg). | 2020-08-08 |
| 32761248 | Psychological research on COVID-19 suggests that people are more anxious than historical norms and moderately to extremely upset about fertility treatment cancellation owing to COVID-19. […] Second, closure was appraised as a threat to attainability of the parenthood goal largely due to uncertainty of the situation (e.g., re-opening, effect of delay) and intensification of pre-existing hardships of fertility problems (e.g., long time waiting for treatment, history of failed treatment). | 2020-08-08 |
| 32761374 | Data from general admission, intensive care units, and elective and emergency surgeries were collected and analyzed. | 2020-08-08 |
| 32761481 | Therefore, strengthening the diagnosis of the disease is particularly important for children, and early and clear diagnosis can determine treatment strategies and reduce the harm caused by the disease to children. […] According to the Novel Coronavirus Infection Pneumonia Diagnosis and Treatment Standards (trial version 7) issued by National Health Committee and the latest diagnosis and treatment strategies for novel coronavirus infection pneumonia in children, this review summarizes current strategies on diagnosis and treatment of SARS-CoV-2 infection in children. | 2020-08-08 |
| 32761491 | Mesenchymal stem cell (MSC) therapy is the immediate treatment used for patients with severe cases of COVID-19. […] Herein, we describe two confirmed cases of COVID-19 in Wuhan to explore the role of MSC in the treatment of COVID-19. […] Results indicated that MSC transplantation provides clinical data on the treatment of COVID-19 and may serve as an alternative method for treating COVID-19, particularly in patients with ARDS. | 2020-08-08 |
| 32761894 | These include both the course and treatment of diseases. | 2020-08-08 |
| 32761900 | Collected data included demographic information, epilepsy-related characteristics (seizure type, frequency, antiepileptic drugs [AEDs], and medication management), direct and perceived threat of COVID-19, and changes in seizures during the outbreak. […] Exposure history to COVID-19 (P = .001), uncontrolled seizure after AED therapy (P = .020), seizure frequency of two or more times per month before the outbreak (P = .005), change of AED regimen during the outbreak (AED reduction, withdrawal, replacement, skipping altogether; P = .002), and worry about the adverse effect of the outbreak on overall seizure-related issues (severity = moderate to critical; P = .038) were risk factors for increased seizures. | 2020-08-08 |
| 32761981 | All patients receiving reperfusion therapy for ischaemic stroke between 30 December 2019 and 3 May 2020 were recorded, and their baseline, clinical and radiological characteristics, extra- and intra-hospital times of action, Code Stroke activation pathway, COVID-19 status, reperfusion rate, and short-term outcome before and after the setting of the emergency state were analysed. […] Patients receiving endovascular therapy obtained less successful reperfusion rates (92.9% vs. | 2020-08-08 |
| 32762043 | The COVID-19 pandemic has dramatically challenged care for cancer patients, especially those with active treatment that represent a vulnerable population for SARS-CoV-2 infection. […] Because of that, our clinical practice was changed so as to minimize risk of SARS-CoV-2 infection while continuing haematological treatment. […] In this report, we analyse the management of front-line therapy in 18 patients during COVID-19 outbreak, as well as the results of the implemented measures in their outcome. | 2020-08-08 |
| 32762106 | Demographic, clinical, laboratory, and treatment data were obtained from the registry and compared between hospitalized and nonhospitalized patients as well as those with critical illness. | 2020-08-08 |
| 32762118 | COVID-19 is associated with a substantial risk of venous thrombotic events, even in the presence of adequate thromboprophylactic therapy. […] We aimed to better characterize the hypercoagulable state of COVID-19 patients in patients receiving anticoagulant therapy. […] We took plasma samples of 23 patients with COVID-19 who were on prophylactic or intensified anticoagulant therapy. […] Ongoing activation of coagulation despite normal to intensified anticoagulant therapy indicates studies on alternative antithrombotic strategies are urgently required. | 2020-08-08 |
| 32762158 | Dynamic monitoring as well as early prevention and treatment are of great significance for improving the prognosis of patients. | 2020-08-08 |
| 32762168 | Nutritional support is an indispensable part in the treatment of critically ill patients with coronavirus disease 2019 (COVID-19). […] For patients with normal gastrointestinal function who require prone position ventilation or receive extracorporeal membrane oxygenation (ECMO) treatment, enteral nutrition is recommended as the first choice. […] Based on the metabolic characteristics of critically ill patients with COVID-19, this paper makes a summary and suggestion on the following perspectives such as nutritional risk screening and assessment, target amount of nutritional treatment, nutritional intervention and treatment, nutritional support of special populations, and common adverse reactions in nutritional support treatment, so as to provide reference for individualized nutritional support therapy of critically ill patients with COVID-19. | 2020-08-08 |
| 32762368 | Despite the correction of hypoxemia and the absence of reversible factors, such as adverse medication effects, electrolyte derangements, and usage of hydroxychloroquine/azithromycin, the QT interval remained persistently prolonged compared with the baseline with subsequent degeneration into ventricular tachycardia and death. | 2020-08-09 |
| 32762374 | Following the administration of convalescent plasma therapy and inotropic support, left ventricular function recovered fully in accordance with the decrease in the concentration of the inflammatory markers. | 2020-08-09 |
| 32762477 | Telemedicine technology has become essential to healthcare delivery in the COVID-19 era, but concerns remain regarding whether the intimacy and communication that is central to high-quality palliative care will be compromised by the use of this technology. […] We employed a business model approach to identify the need for system innovation in palliative care, and a quality improvement approach to structure the project. […] Products from this project included a standard operating procedure for safe use of tablet computers for inpatient palliative care consultations and family visitations; tablet procurement with installation of video telehealth software; and training and education for clinical staff and other stakeholders. […] We describe a case illustrating the successful use of palliative care telehealth in the care of a COVID-19-positive patient at the end of life. […] Successful use of video telehealth for palliative care involved overcoming inertia to the development of telehealth infrastructure and learning clinical video telehealth skills; and engaging front-line care staff and family members who were open to a trial of telehealth for communication. | 2020-08-09 |
| 32762488 | Most cases of COVID-19 are considered mild, but patients with immunosuppressant treatment might be prone to severe courses of disease. […] Expert panels advise to delay treatment with cell-depleting MS therapies during the COVID-19 pandemic. […] We report a case of a patient with relapsing-remitting multiple sclerosis who developed COVID-19 pneumonia 2 weeks after the first week of cladribine therapy. […] Apart from maximal supportive treatment, this could be due to cladribine reducing inflammatory response, which probably contributes considerably to severe courses of COVID-19 pneumonia. | 2020-08-09 |
| 32762511 | The selection of Tinospora cordifolia was motivated by the fact that the main constituents of it are known to be responsible for various antiviral activities and the treatment of jaundice, rheumatism, diabetes, etc. | 2020-08-09 |
| 32762561 | In the absence of specific guidelines for the prevention and treatment of COVID-19 for patients with diabetes, they remain at higher risk and are more susceptible to COVID-19. […] In consideration of the higher risk of mortality in patients with diabetes and COVID-19, novel diagnostic test and treatment strategy are urgently warranted in post-COVID-19 era. | 2020-08-09 |
| 32762696 | The treatment modalities for pediatric COVID-19 patients were not as complex as those of adult COVID-19 patients. | 2020-08-09 |
| 32762723 | We describe the clinical presentation, diagnosis, treatment, and outcome. | 2020-08-09 |
| 32762834 | We propose the systematic use of LDCT in addition to RT-PCR testing because it helps correct false-negative RT-PCR results, because its results are available much faster than those of RT-PCRtesting, and because it provides additional diagnostic information useful for treatment planning regardless of the type of the infectious agent. | 2020-08-09 |
| 32763089 | As the backbone for the treatment of patients with coronavirus disease 2019 (COVID-19), nurses have been playing key roles in cabin hospitals, isolation wards, and intensive care units for critical cases. […] With rich experience in emergency responses and nursing, anesthesia nurses, along with emergency nurses and critical care nurses, play important roles during the treatment of patients with COVID-19. […] Given their specialty, anesthesia nurses have played important roles in the treatment of patients with COVID-19. | 2020-08-09 |
| 32763101 | On day-1, ARDS-net/prone positioning ventilation, and empiric anti-COVID treatment integrating prophylactic anticoagulation was administered. […] Intravenous alteplase (100 mg over 2 h) was administered as rescue therapy. | 2020-08-09 |
| 32763298 | Also, regular control of retina should be considered for patients under HCQ treatment. […] The major focus of the present review is to discuss about the pharmacokinetic and pharmacodynamic properties of CQ and HCQ that may be influenced by epigenetic mechanisms, and consequently cause several side effects especially retinopathy during SARS-CoV-2 therapy. | 2020-08-09 |
| 32763302 | However, until now, no promising treatment options, as well as vaccines, are available. | 2020-08-09 |
| 32763357 | We utilized treatment effects with inverse-probability-weighting and Cox proportional hazards models. […] Nevertheless, the treatment was safely studied under the guidance of an antimicrobial stewardship program. | 2020-08-09 |
| 32763444 | Health systems must plan to provide adequate access to rehabilitative facilities for both pulmonary and motor rehabilitative treatment after COVID-19. | 2020-08-09 |
| 32763457 | Chronic limb ischemia was the indication to treatment in 24 (20.7%) patients. | 2020-08-09 |
| 32763536 | A 23 item interview proforma comprising of self-reported knowledge related to COVID-19 by patients and their illness and treatment status from their caregivers. […] One out of five patients lacked knowledge of the mode of transmission and stopped their psychiatric treatment. | 2020-08-09 |
| 32763640 | Follow-up phone interviews with patients revealed that while many were interested in getting follow-up for their symptoms, there were many barriers to accessing appropriate therapy and clinical attention. […] This study demonstrates the high prevalence of ICU-related PTSD in our cohort of survivors, the high barrier to accessing care for appropriate treatment of PICS, and the consequence of that barrier-prolonged psychological morbidity. | 2020-08-09 |
| 32763844 | We encourage studies on the effectiveness of multiple sclerosis drugs for the treatment of ARDS in COVID-19 infection. | 2020-08-09 |
| 32763890 | Challenges exist in patients accessing facial neuromuscular retraining (NMR), a therapy used to strengthen muscle and improve nerve function. […] Access to therapy could potentially be improved through the use of digital technology. […] However, there is limited research available on patients’ and clinicians’ views about the potential benefits of such telerehabilitation based on their lived experiences of treatment pathways. […] This study aims to gather information about facial palsy treatment pathways in the United Kingdom, barriers to accessing NMR, factors influencing patient adherence, measures used to monitor recovery, and the potential value of emerging wearable digital technology. […] Separate surveys of patients with facial palsy and facial therapy specialists were conducted. […] Questionnaires explored treatment pathways and views on telerehabilitation, were co-designed with users, and followed a similar format to enable cross-referencing of responses. […] Significant variations were observed in individual treatment pathways. […] For patients diagnosed most recently, there was evidence of more rapid initial prescribing of corticosteroids (prednisolone) and earlier referral for NMR therapy. […] The study findings provide valuable information on facial palsy treatment pathways and views on the future introduction of digital technology. | 2020-08-09 |
| 32763956 | On day 21, 1 day after starting physical therapy, he developed acute bilateral arthritis in his ankles, with mild enthesitis in his right Achilles tendon, without rash, conjunctivitis, or preceding diarrhoea or urethritis. | 2020-08-09 |
| 32764120 | Successful management of acute bacterial infections requires early diagnosis and treatment, which are not always easy to achieve. | 2020-08-09 |
| 32764200 | Convalescent plasma is a leading treatment for coronavirus disease 2019 (COVID-19), but there is a paucity of data identifying its therapeutic efficacy. | 2020-08-09 |
| 32764665 | Furthermore, although tocilizumab treatment attenuates the inflammation, immune cells, including plasma B cells and CD8+ T cells, still exhibit robust humoral and cellular antiviral immune responses. | 2020-08-09 |
| 32764907 | Moreover, there is evidence that ACE genotype affects the outcomes of acute respiratory distress syndrome (ARDS) treatment, the most severe consequence of SARS-CoV-2 infection. […] There is no direct evidence yet for ACE-I or ARBs in the treatment of COVID-19. […] However, for those already taking these medications, both the European Society of Cardiology and the American College of Cardiology recommend continuing the treatment, because at present, there is no clear clinical or scientific evidence to justify the discontinuation of ACE-I or ARBs. […] Individualized treatment decisions should be based on the clinical condition and co-morbidities of each patient. | 2020-08-09 |
| 32765013 | The three mentioned CoVs exhibit some similarities in S protein whereby constitute a promising target for the development of prophylactics and therapeutics in the future. | 2020-08-09 |
| 32765138 | Epidemiological, demographic, clinical, laboratory, radiological, treatment data, and clinical outcomes were collected. | 2020-08-09 |
| 32765274 | However, there is no specific antiviral therapy for coronavirus disease 2019 (COVID-19). […] We conducted a clinical trial to compare the effectiveness of three antiviral treatment regimens in patients with mild to moderate COVID-19. | 2020-08-09 |
| 32765283 | These findings may guide future treatment of COVID-19 patients. | 2020-08-09 |
| 32765482 | However, approved antiviral agents for the treatment of patients with COVID-19 remain unavailable. […] A combination of repurposed drugs can improve the efficacy of treatment, and structure-based drug design can be employed to specifically target SARS-CoV-2. | 2020-08-09 |
| 32765592 | A detailed understanding of the molecular mechanism of SARS-CoV-2 pathogenesis is still elusive, and there is a need to address its deadly nature and to design effective therapeutics. […] These results will also be useful in designing RNA therapeutics to alleviate the complications from COVID-19. | 2020-08-09 |
| 32765712 | Therefore, it is important to include frequent symptoms in the anamnesis and questionnaires to select those patients who might benefit from testing, isolation, and treatment. | 2020-08-09 |
| 32765938 | The lack of a valid, accepted treatment protocol and vaccine that leads to continued treatment searches. […] Leng et al published their article in the Aging and Disease journal, which demonstrates that mesenchymal stem cells (MSCs) can be used for COVID-19 treatment. […] Finally, Gentile and Sterodimas, have also published their article for the potential use of SVF in COVID-19 treatment in Aging and Disease journal. […] While suggesting any adipose tissue-derived treatment method possibility, the relation of adipose tissue COVID-19 should not be ignored. | 2020-08-09 |
| 32765941 | This proposal implies that pretreatment of MSCs with BALs enhance their physiological action or improve their (MSCs) anti-inflammatory and disease resolution capacity to a significant degree. […] Since PGE2, LXA4 and their precursors AA (arachidonic acid), dihomo-gamma-linolenic acid (DGLA) and gamma-linolenic acid (GLA) inhibit the production of pro-inflammatory IL-6 and TNF-α, they could be employed to treat cytokine storm seen in COVID-19, immune check point inhibitory (ICI) therapy, sepsis and ARDS (acute respiratory disease). […] Thus, infusions of appropriate amounts of GLA, DGLA, AA, PGE2 and LXA4 are of significant therapeutic benefit in COVID-19, ICI therapy and other inflammatory conditions including but not limited to sepsis. | 2020-08-09 |
| 32765943 | They were also more prone to develop into severe or critically severe cases, receive ICU admission, and require respiratory support treatment. | 2020-08-09 |
| 32766087 | Rates of breast cancer diagnoses are rising, and more women are seeking mastectomy as treatment and as prophylaxis. | 2020-08-09 |
| 32766161 | Abnormal coagulation parameters and potential benefits of anticoagulant therapy in general population with novel coronavirus pneumonia (COVID-19) have been reported. […] Importantly, three patients, one severe and two critical ill type, with increased D-dimer survived after anticoagulant therapy with continuous heparin infusion. […] Cancer patients with COVID-19 showed prominent hypercoagulability associated with severe inflammation, anticoagulation therapy might be useful to improve the prognosis and should be immediately used after the onset of hypercoagulability. | 2020-08-09 |
| 32766266 | Polyclonal preparation of IgM as an adjuvant therapy has been reported as a relevant immunomodulant therapy in several infectious diseases, exhibiting, in most cases, improvement of the clinical course. […] Immunomodulatory treatment with hydroxychloroquine and biologics as tocilizumab, in fact, has not proven to show satisfactory results in several reports. […] We therefore treated a selected patient with interstitial multifocal pneumonia, positive to COVID-19, with polyclonal preparation of immunoglobulins as an adjuvant therapy, obtaining in few days clinical remission and improvements in radiological findings. […] Based on this case report, we suggest that clinical trials are conducted to test the efficacy and safety of polyclonal immunoglobulins for adjunctive therapy of COVID-19. | 2020-08-09 |
| 32766396 | Surgery in the time of COVID-19 pandemic is a challenging issue while treatment of affected fracture patients is inevitable. […] The present study summarizes the challenges that an orthopedic surgeon is confronting during the surgical treatment of fracture patients with concomitant COVID-19 infection. | 2020-08-09 |
| 32766417 | Experts from Cina, UK and US suggested to reconsider thrombolysis as the best treatment in term of balance between time consumption and operators safety for ST-segment elevation myocardial infarction (STEMI) patients respect to primary PCI (pPCI). […] No significant differences were found among the two groups regarding key time points of STEMI care and interestingly we didn’t find any treatment delay in pCOV+. […] In conclusion, a focused overhaul of the EMS may allow to maintain pPCI as the treatment of choice for patients and operators. | 2020-08-09 |
| 32766461 | The effect of quarantine and centralized medical treatment was also measured through numerical modeling analysis. | 2020-08-09 |
| 32766497 | However, we acknowledge that this may come at the expense of the overtreatment of viral infiltrates and atelectasis. | 2020-08-09 |
| 32766535 | The interleukin-6 receptor inhibitor tocilizumab is used for the treatment of chimeric antigen receptor T-cell therapy-induced CRS. […] Patients aged 18 years or older with laboratory-confirmed COVID-19 admitted to the Annunziata Hospital in Cosenza, Italy, through March 7, 2020, who received at least one dose of tocilizumab 162 mg subcutaneously for the treatment of COVID-19-related CRS in addition to standard care were included in this retrospective observational study. […] The primary observation was the incidence of grade 4 CRS after tocilizumab treatment. […] Seven patients received high-flow nasal cannula oxygen therapy and five received non-invasive mechanical ventilation for lung complications of COVID-19. […] Follow-up CT scans 7 to 10 days after tocilizumab treatment showed improvement of lung manifestations in all patients. […] Tocilizumab administered subcutaneously to patients with COVID-19 and CRS is a promising treatment for reduction in disease activity and improvement in lung function. | 2020-08-09 |
| 32766537 | Tocilizumab was approved for chimeric antigen receptor T-cell therapy induced cytokine release syndrome and it may provide clinical benefit for selected COVID-19 patients. | 2020-08-09 |
| 32766566 | The purpose of this study was to report our experience in terms of ICU organization and anticipation, as well as reporting patient characteristics, treatment, and outcomes. | 2020-08-09 |
| 32766569 | To determine whether Seraph-100 (Exthera Medical Corporation, Martinez, CA) treatment provides clinical benefit for severe coronavirus disease 2019 cases that require mechanical ventilation and vasopressor support. […] These cases were reviewed by the Food and Drug Administration prior to granting an emergency use authorization for treatment of coronavirus disease 2019. | 2020-08-09 |
| 32766706 | We performed an international web-based survey and investigated the pattern of antibiotic use as reported by physicians involved in treatment of COVID-19. […] The mean reported duration of antibiotic treatment was 7.12 (SD = 2.44) days. […] Implementation of antimicrobial stewardship principles is warranted to mitigate the negative consequences of antibiotic therapy. | 2020-08-09 |
| 32766756 | To define changes in AMI case rates, patient demographics, cardiovascular comorbidities, treatment approaches, and in-hospital outcomes during the pandemic. […] The secondary outcomes were patient characteristics, treatment approaches, and in-hospital outcomes of this patient population. […] No appreciable differences in patient demographics, cardiovascular comorbidities, and treatment approaches were observed across periods. | 2020-08-09 |
| 32766846 | However, subsequent large prospective epidemiological surveys indicate that the risk for severe COVID-19 may be largely attributed to the multiple confounders operating in this highly heterogeneous population of patients rather than the cancer or its treatment per se. […] In this viewpoint, we critically discuss the conundrums of SARS-CoV-2 infection in cancer patients and underscore mechanistic insights on the outcome of COVID-19 as it relates to cancer therapy and the type and status of the underlying malignancy. | 2020-08-09 |
| 32767260 | To standardize and share the treatment procedures of severe and critically ill cases, Wuhan Union Hospital has established a working group and formulated an operational recommendation, including the monitoring, early warning indicators, and several treatment principles for severe and critically ill cases. […] The treatment experiences may provide some constructive suggestions for treating the severe and critically ill COVID-19 cases all over the world. | 2020-08-09 |
| 32767286 | Adrenal insufficiency (AI) requires life-long treatment with glucocorticoid replacement therapy. […] Glucocorticoid replacement therapy needs to be flexible with dose adaptation in special situations. […] This could not be managed by medical personnel on a daily basis, but requires an educated patient who has a good knowledge of the disease, understands his medical therapy and is able to perform situational dose adaptation. […] The rarity of the disease in combination with the need to respond to stressful situations with rapid glucocorticoid dose adjustment underlines that a well-trained patient is crucial for optimal management of the disease.In this literature review we provide background information further clarifying the need of education in patients with AI including the current shortcomings of medical therapy and of the treatment of patients with AI. | 2020-08-09 |
| 32767296 | In Germany, an exponential increase in the number of infections was registered at the beginning of March 2020 and led to a call of the Ministry of Health to create more capacity for intensive medical treatment in hospitals. […] In contrast, emergency treatment remained unchanged or even increased in 80 % of the facilities and surgical treatment of emergency patients remained unchanged or even increased in more than 90 %. […] Emergency outpatient and surgical treatment of patients was provided throughout the pandemic in all facilities. […] As a result of the acute structural changes, the potential danger of falling below current treatment standards was seen in individual areas of patient care. […] The majority of the chairmen are critically aware of the risk of falling below current medical treatment standards or guidelines. […] In the phase of an exponential increase in the number of infections, significant changes in treatment processes had to be accepted for understandable reasons. […] However, with the currently significantly reduced number of infections, falling below treatment standards and guidelines should not be allowed to remain constant and tolerated. | 2020-08-09 |
| 32767349 | Corticosteroid therapy in patients with severe COVID-19 cannot reduce the hospital mortality, and is not associated with delayed viral clearance, but it could relieve the inflammatory storm and improve clinical symptoms in brief. […] Patients with severe COVID-19 could benefit from low-dose corticosteroid treatment. | 2020-08-09 |
| 32767351 | According to the Guidelines on Novel Coronavirus-Infected Pneumonia Diagnosis and Treatment (Provisional 6th Edition), COVID-19 patients were divided into mild type (7), common type (34), severe type (7) and critical type (10 patients). | 2020-08-09 |
| 32767353 | Age, sex, length of stay (LOS), pharmacological treatment, and timing of antiviral administration (morning or evening), were recorded. […] The total sample consisted of 151 patients, 33 (21.8%) of whom were selected for antiviral treatment. | 2020-08-09 |
| 32767466 | Updated clinical protocols should be established for the new normal period in accordance with these findings. | 2020-08-09 |
| 32767631 | This clinical case suggests that coronary thrombosis in COVID-19 patients may be unresponsive to optimal pharmacological (GP IIb-IIIa infusion) and mechanical treatment (PCI). | 2020-08-09 |
| 32767687 | Currently, no treatment effective for COVID-19 is available in the form of vaccines or antiviral drugs and patients are currently treated symptomatically. […] Recent use of stem cells for critically ill COVID-19 patients in a small group of patients in China and subsequent Emergency Use Authorization of stem cells by Food and Drug Administration to Global Institute of Stem Cell Therapy and Research and Athersys has created excitement among the medical community. […] As a result, several clinical trials have been registered using stem cells for COVID-19 treatment that aim to use different cell sources, dosage, and importantly diverse targeted patient groups. | 2020-08-09 |
| 32767707 | Utilizing the adaptive, data-driven programme approaches in facilities and communities established and supported by PEPFAR provides the opportunity to strengthen the COVID-19 response while protecting the immense gains spanning HIV prevention, testing and treatment reached thus far. | 2020-08-09 |
| 32767823 | A meta-analysis of eligible studies comparing the occurrence of severe and fatal COVID-19 in infected hypertensive patients who were under treatment with angiotensin-converting enzyme inhibitors (ACEI) or angiotensin receptor blockers (ARB) vs no treatment or other antihypertensives was conducted. | 2020-08-09 |
| 32767852 | Surgical nurses and nurses with positive professional perceptions are more likely to be willing to participate in treatment. | 2020-08-09 |
| 32767858 | Face-to-face psychotherapy decreased by 56% but videoconferencing therapy was only used by 22% of patients. […] In challenging times when face-to-face therapy options are restricted, e-health treatments such as videoconferencing therapy should be considered to ensure continuity of care. | 2020-08-09 |
| 32767920 | At this moment, there is no specific treatment and the therapeutic strategies to deal with the infection are only supportive, and prevention aimed at reducing community transmission. […] Indian Traditional System, Ayurveda has a clear concept of the cause and treatment of pandemics. | 2020-08-10 |
| 32768101 | Psychiatric services can play a key role in addressing this issue by (a) addressing certain risk factors for perpetration of domestic violence through, for example, assertive identification and management of substance misuse; (b) providing support, advocacy and treatment services for victims of domestic violence; and (c) multi-agency working to strengthen medical and social responses to domestic violence. | 2020-08-10 |
| 32768138 | It included all patients admitted for urgent abdominal pathology with potential surgical treatment in our General and Digestive Surgery Department from February 24, 2020 to April 19, 2020. | 2020-08-10 |
| 32768311 | This study explored the early impact of COVID-19 on the emotional well-being of patients and self-reported changes in their home therapy since the start of the pandemic. […] The questionnaire covered the emotional impact of the pandemic, changes in CF and LTX treatment, changes in health-protecting behaviours and CF-related concerns, and their perception of their COVID-19 status. […] Changes in treatment were positive, including more physiotherapy for adults and better-quality nebulizing. […] Changes in routine were reported, such as different treatment timing. […] The impact on home treatment was reassuringly small. | 2020-08-10 |
| 32768388 | Facing children with suspected or confirmed COVID-19, health professionals should 1) diagnose excess weight; 2) advise on health care in times of isolation; 3) screen for comorbidities, ensuring that treatment is not interrupted; 4) measure levels of immunonutrients; 5) guide the family in understanding the specifics of the situation; and 6) refer to units qualified to care for obese children and adolescents when necessary. | 2020-08-10 |
| 32768490 | Melatonin, a multifunctional neurohormone mainly synthesized and secreted by the pineal gland, plays some roles in the treatment of viral infections. […] Therefore, in this review, we summarize current evidence on melatonin therapy for viral infections with focus on possible underlying mechanisms of melatonin actions. | 2020-08-10 |
| 32768693 | After accounting for differences in disease severity at treatment initiation, this apparent superiority of anakinra over tocilizumab was no longer statistically significant (propensity score-adjusted hazards ratio 0.46, 95% confidence interval 0.18-1.20). […] Prompt identification and treatment of COVID19-CS before intubation may be more important than the specific type of anti-inflammatory treatment. | 2020-08-10 |
| 32768696 | A description of the subgroup of people at higher risk of mortality will be crucial for prioritizing and implementing future public health prevention and treatment programs. | 2020-08-10 |
| 32768701 | None of the TCZ-treated patients had disease progression, defined as requirement of oxygen therapy or mechanical ventilation, whereas progression occurred in five (50%) patients among the SOC group. | 2020-08-10 |
| 32768772 | Hearing and balance deficits have been reported during and following treatment with the antimalarial drug chloroquine. […] These findings suggest a need for future studies employing hearing and balance monitoring during exposure to chloroquine and related compounds, particularly with interest in these compounds as therapeutics against viral infections including coronavirus. | 2020-08-10 |
| 32768790 | Sampling was carried out on 8 and 27 May 2020 at the Old Pirana Waste Water Treatment Plant (WWTP) at Ahmedabad, Gujarat that receives effluent from Civil Hospital treating COVID-19 patients. | 2020-08-10 |
| 32768938 | A total of 40 patients with yidu-toxicity blocking lung syndrome, diagnosed as severe pneumonia of SARS-COV-2 following the latest Chinese national recommendations for the diagnosis and treatment of pneumonia caused by SARS-COV-2 (the 5th edition), were recruited. […] They were randomly divided into the pure western medicine therapy group (PWM) and integrated into Chinese and Western medicine therapy group (ICW). […] The results showed that IL-6 (P = 0.013) and TNF-α (P = 0.035) levels in the PWM group were significantly higher than those in the ICW group after treatment. […] CM can serve as a complementary medication to western medicine, which should be highlighted in clinical settings. | 2020-08-10 |
| 32768971 | Meanwhile efforts to find an effective treatment to inhibit virus replication, mitigate the symptoms, increase survival and decrease mortality rate are ongoing. […] Herein we will provide an updated overview of the natural history and current knowledge on drugs and therapeutic agents being tested for the prevention and treatment of COVID-19. | 2020-08-10 |
| 32768974 | No specific medication is approved to treat COVID-19, raising the urgent need for antiviral drug development. […] By 12 June 2020, there are over 1000 clinical trials registered in clinicaltrials.gov for treatment of COVID-19. […] This review summarizes the epidemiology, virology, clinical presentation, pathophysiology, diagnosis, and particularly the antiviral drugs currently under clinical trials for treatment of SARS-CoV-2 infection, together with the challenges and perspectives of this disease are also discussed. | 2020-08-10 |
| 32768975 | Qingfei Paidu decoction (QPD)3 is strongly recommended in the Chinese Novel Coronavirus Pneumonia Diagnosis and Treatment Plan (Provisional 6th Edition). […] Our study aimed to explore the effects of combined treatment with QPD and Western medicine on COVID-19. […] During the first 14 days of hospitalization, patients with deteriorating symptoms were administered QPD along with Western medicine therapy (the antiviral medicine selected from interferon, lopinavir, or arbidol). […] The clinical characteristics and blood laboratory indices (blood routine, inflammatory factors, and multi-organ biochemical indices) were examined, and the total lung severity scores were evaluated in each patient by reviewing chest computed tomography before treatment and at the end of treatment. […] Before QPD treatment, the combined treatment group showed higher blood C-reactive protein levels and more severe pulmonary inflammation and clinical symptoms than the Western medicine treatment group. […] At the end of treatment, circulating white blood cells, total lymphocyte count, and glutamic-oxaloacetic transaminase levels improved dramatically in both groups (P < 0.05). […] In contrast, C-reactive protein, creatine kinase, creatine kinase-myocardial band, lactate dehydrogenase, and blood urea nitrogen levels were improved only in the combined treatment group (P < 0.05), and C-reactive protein and creatine kinase were the most pronounced (P < 0.01). […] Compared with baseline, at the end of treatment, the proportion of patients with normal values of C-reactive protein, total lymphocyte count, and lactate dehydrogenase were increased in the combined treatment group (P < 0.05), whereas no significant difference was observed in the Western medicine treatment group (P > 0.05). […] Moreover, the combined treatment tended to mitigate the extent of multi-organ impairment. | 2020-08-10 |
| 32768994 | The objective of this study is to provide an analysis of treatment and management-related functionality and characteristics of high-rated mobile applications (apps) for anxiety, which are available for Android and iOS systems. […] The apps adopted various treatment and management approaches such as meditation, breathing exercises, mindfulness and cognitive behavioral therapy. | 2020-08-10 |
| 32769050 | Therefore, 3CLpro has emerged as promising drug target for therapeutic treatment of infections caused by Coronaviruses. | 2020-08-10 |
| 32769063 | Limited data suggest vaccine responses to be preserved with dimethyl fumarate treatment, as well. […] Responses to any vaccination depend on the vaccine type, the type of response (recall versus response to a novel antigen), and the impact of the individual disease-modifying therapy on humoral and cellular immunity in response to that vaccine type. […] When considering a given therapy, clinicians should weigh its efficacy against MS for the individual patient versus potential impact on responses to vaccinations that may be needed in the future. | 2020-08-10 |
| 32769075 | Older cancer survivors, faced with both age- and treatment-related morbidity, are at increased and premature risk for physical function limitations. | 2020-08-10 |
| 32769128 | To examine whether HbA1c, outpatient diabetes treatment regimen, demographics, and clinical characteristics are associated with mortality in hospitalized patients with diabetes and coronavirus disease 2019 (COVID-19). […] Multivariate modeling was used to assess the independent association of HbA1c levels and outpatient diabetes treatment regimen with mortality, in addition to independent effects of demographic and clinical characteristics. […] HbA1c levels were not associated with mortality in unadjusted or adjusted analyses, but an outpatient regimen with any insulin treatment was strongly predictive. […] In this large U.S. cohort of hospitalized patients with diabetes and COVID-19, insulin treatment, as a possible proxy for diabetes duration, and obesity rather than long-term glycemic control were predictive of mortality. | 2020-08-10 |
| 32769228 | We then apply this ethical framework to evidence-based treatment and its improvement, planned home birth, ring-fencing obstetric services, attendance of spouse or partner at birth, and the responsible management of organizational resources. | 2020-08-10 |
| 32769230 | We describe the demographic, clinical and laboratory findings along with the treatment and outcomes among children meeting the case definition of Pediatric Inflammatory Multisystem Syndrome - Temporally Associated with SARS-CoV-2 (PIMS-TS). | 2020-08-10 |
| 32769235 | Bronchoscopy plays an important role in diagnosis and therapy of pulmonary diseases, especially in patients with severe pulmonary infection, however, application of bronchoscopy in patients suspected or confirmed SARS-CoV-2 infection is extremely limited for the potential airborne transmission from aerosol generated during the procedure. | 2020-08-10 |
| 32769321 | Diagnostic laboratories testing different types of samples play a vital role in the treatment management. | 2020-08-10 |
| 32769322 | Knowledge of the viral structure, factors that help in its progression and spread, pathological findings, diagnostic methods and, treatment modalities helps in understanding the viral disease and also in treating the patients in a better way besides preventing the community spread of this deadly infection. […] Different treatment modalities are being tried and under trial. […] This review article thus highlights the global epidemiological status, characteristic of the virus, symptomatology of the patients, role of diagnostic tests available, organs affected including their morphological changes and the latest line of treatment of COVID-19. | 2020-08-10 |
| 32769401 | The United States Food and Drug Administration has declared that the potential benefits of these agents no longer outweigh the possible risks, and unless new emerging information suggests a more favorable risk:benefit ratio, neither chloroquine nor hydroxychloroquine should be recommended for COVID-19 treatment or prevention at this time. | 2020-08-10 |
| 32769659 | Because pregnant women are at increased risk for hospitalization, intensive care unit admission, and mechanical ventilation support, obstetricians will be facing the dilemma of initiating maternal corticosteroid therapy while weighing its potential adverse effects on the fetus (or neonate if the patient is postpartum and breastfeeding). […] Our objective is to summarize the current evidence supporting steroid therapy in the management of patients with acute respiratory distress syndrome and COVID-19 and to elaborate on key modifications for the pregnant patient. | 2020-08-10 |
| 32769869 | To further identify the current role of antiplatelet/anticoagulant therapy in the prophylaxis and treatment of COVID-19 patients is important. | 2020-08-10 |
| 32769892 | This study aimed to evaluate the onset characteristics of patients with uremia undergoing maintenance hemodialysis complicated with COVID-19, so as to improve the understanding, diagnosis, and treatment.26 cases were confirmed cases of COVID-19. […] According to the onset characteristics of this population, early diagnosis and treatment could help reduce the risk of developing a critical illness and control the spread of the COVID-19 epidemic. | 2020-08-10 |
| 32769921 | In China, the Shufeng Jiedu capsule has been widely used in the treatment of COVID-19, but there is still a lack of evidence-based medical evaluation. […] This study will evaluate the efficacy and safety of the Shufeng Jiedu capsule in the treatment of COVID-19 and provide a more reasonable choice of medication in clinical practice. | 2020-08-10 |
| 32769922 | At present, there is no highly effective medicine for the prevention and treatment of 2019-nCoV. […] Western medicine for COVID-19 is mainly based on symptomatic support therapy. […] Western medicine routine treatment combined with Chinese herbal medicine is an alternative clinical option but lacks evidence-based medical evidence. […] The systematic review protocol aims to formulate a research plan that can evaluate the efficacy and safety of western medicine routine treatment combined with Chinese herbal medicine for COVID-19. […] We will provide evidence-based medical evidence of the efficacy and safety of western medicine routine treatment combined with Chinese herbal medicine for COVID-19. | 2020-08-10 |
| 32770240 | In May 2020 the Russian Ministry of Health granted fast-track marketing authorization to RNA polymerase inhibitor AVIFAVIR (favipiravir) for the treatment of COVID-19 patients. | 2020-08-10 |
| 32770414 | Presented herein is a severe case of SARS-CoV-2 associated Guillain-Barré syndrome (GBS), showing only slight improvement despite adequate therapy. | 2020-08-10 |
| 32770646 | By far, a KT recipient seems to develop more severity despite antiviral therapy, cessation of immunosuppressant, and aggressive intensive care support. | 2020-08-10 |
| 32770652 | The diverse scope of clinical practice involves highly specialized assessment and treatment practices in patients in high-risk categories. | 2020-08-10 |
| 32770691 | Recently, there have been several reports with inconsistent results after treatment with convalescent plasma (CP) on critically ill patients with COVID-19, which was produced with a neutralizing antibody titer and tested in a P3 or P4 laboratory. […] No therapeutic effect of CP was observed in any of the patients; instead, all three patients deteriorated and required extracorporeal membrane oxygenation treatment. | 2020-08-10 |
| 32770797 | Most of patients with severe COVID-19 pneumonia showed marked improvement of acute exudative lesions on chest imagings, and satisfactory prognosis of severe COVID-19 pneumonia could be achieved after active treatment. | 2020-08-10 |
| 32770825 | Efforts made to develop antiviral strategies for the treatment of COVID-19 are underway. […] Numerous types of antibiotics such as azithromycin have been employed for the prevention and treatment of bacterial co-infection and secondary bacterial infections in patients with a viral respiratory infection (e.g., SARS-CoV-2). | 2020-08-10 |
| 32770854 | There is not treatment for COVID-19, and several anti-inflammatory and antiviral molecules are being tested, and different vaccines are in preparation. […] Thus, looking for an effective treatment of COVID-19 is mandatory. […] Because COVID-19 courses with a severe septic response, multiple reviews proposing melatonin as a treatment for COVID-19 have been published. | 2020-08-10 |
| 32770858 | The purpose of this review is to elaborate on the more precise mechanism(s) to manage the treatment of the disease. | 2020-08-10 |
| 32771032 | Those pregnant or lactating, severely dyspneic or with respiratory distress, already undergoing treatment, and with serious comorbidities like liver or kidney failure will be excluded. | 2020-08-11 |
| 32771034 | Inclusion Criteria: - Patients with mild COVID19 (defined as upper respiratory tract infection symptoms in the absence of clinical or radiological signs of pneumonia). - Adult (18 - 65 years old). - Written informed consent by the patient (or legally authorized representative) prior to initiation of any study procedures. - All patients should understand and agree to comply with planned study procedures. - Polymerase chain reaction (PCR)-confirmed infection with Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) from throat swab. - Patients with pneumonia or severe illness requiring admission to intensive care unit. - Severe chronic kidney disease (i.e. estimated glomerular filtration rate [eGFR] < 30 mL / min) or end stage renal disease requiring dialysis - Severe chronic liver disease (Alanine transaminase [AlT] or Aspartate transaminase [AST] > 5 times the upper limit of normal). - Pregnancy or breast feeding. - Anticipated transfer within 72 hours to another hospital that is not a study site. - Allergy to the study medication The trial is currently conducted on patients recruited from King Abdulaziz University Hospital, Jeddah, Saudi Arabia. […] Intervention group: Nigella sativa oil (MARNYS® Cuminmar) 500 mg softgel capsules, one capsule orally twice daily for 10 days plus standard of care treatment (antipyretic, antitussive). […] Comparator group: standard of care treatment. […] Patients will be randomly assigned to treatment or control groups in a 1:1 ratio using a computer-generated randomization scheme (Random permuted blocks of 10) developed using the web-based program: http://www.randomization.com . […] Up to 200 eligible patients will be randomly assigned to either treatment or control groups. | 2020-08-11 |
| 32771068 | Individuals cannot participate if they report having chronic sleep problems (where they have existed for more than three months immediately prior to providing consent), nor will individuals who are actively seeking treatment for their sleep problems irrespective of how long they have had the sleep problem. […] A printed version of this leaflet has been successfully used in previous treatment studies, which have been conducted by our research group. | 2020-08-11 |
| 32771089 | In this modelling study, we used five well described models of HIV epidemics (Goals, Optima HIV, HIV Synthesis, an Imperial College London model, and Epidemiological MODeling software [EMOD]) to estimate the effect of various potential disruptions to HIV prevention, testing, and treatment services on HIV-related deaths and new infections in sub-Saharan Africa lasting 6 months over 1 year from April 1, 2020. […] A 6-month interruption of supply of antiretroviral therapy (ART) drugs across 50% of the population of people living with HIV who are on treatment would be expected to lead to a 1·63 times (median across models; range 1·39-1·87) increase in HIV-related deaths over a 1-year period compared with no disruption. | 2020-08-11 |
| 32771272 | Many parallel studies of convalescent plasma with modest enrolment projections have been launched for the treatment of COVID-19. […] The majority of studies (33 studies with 4440 projected enrolment) will address the treatment of severe and/or critical cases of COVID-19. […] Heterogeneity in product potency due to different antibody titers is anticipated and studies using conventional treatment as controls instead of placebo may complicate our understanding of efficacy. | 2020-08-11 |
| 32771304 | These results provide insights for understanding the infection dynamics and might help develop treatment strategies against COVID-19. | 2020-08-11 |
| 32771337 | Front-line professionals exposed and involved in the diagnosis and treatment of COVID-19 patients are more susceptible. | 2020-08-11 |
| 32771461 | The rapidity and highly communicable nature of the SARS-CoV-2 outbreak has hampered the design and execution of definitive randomized, controlled trials of therapy outside of the clinic or hospital. […] In the absence of clinical trial results, physicians must use what has been learned about the pathophysiology of SARS-CoV-2 infection in determining early outpatient treatment of the illness with the aim of preventing hospitalization or death. […] Therapeutic approaches based on these principles include 1) reduction of reinoculation, 2) combination antiviral therapy, 3) immunomodulation, 4) antiplatelet/antithrombotic therapy, and 5) administration of oxygen, monitoring, and telemedicine. | 2020-08-11 |
| 32771488 | In conclusion, anti-complement therapy may be beneficial in at least some patients with critical COVID-19. | 2020-08-11 |
| 32771560 | Observations between patients with and without asthma were similar when stratified by obesity, other comorbid conditions (ie, hypertension, hyperlipidemia, and diabetes), use of controller asthma medication, and absolute eosinophil count. | 2020-08-11 |
| 32771635 | Patients with anosmia had pneumonia less often (10/37 vs 17/33, p = 0.036), were hospitalized less often (13/37 vs 20/33, p = 0.033), and needed oxygen therapy less often (6/37 vs 17/33, p = 0.002) than patients without anosmia. | 2020-08-11 |
| 32771654 | During the COVID-19 pandemic, surgical delays have been common for patients with ductal carcinoma in situ (DCIS) and early-stage estrogen receptor-positive (ER+) breast cancer, often in favor of neoadjuvant endocrine therapy (NET). […] Analyses were stratified by disease stage and initial treatment strategy. […] Increased time to operation was associated with increased odds of pathologic upstaging in DCIS patients (ER+: 60 to 120 days: odds ratio 1.15; 95% CI, 1.08 to 1.22; more than 120 days: odds ratio 1.44; 95% CI, 1.24 to 1.68; ER-: 60 to 120 days: NS; more than 120 days: odds ratio 1.36; 95% CI, 1.01 to 1.82; 60 days or less: reference), but not in patients with invasive cancer, irrespective of initial treatment strategy. | 2020-08-11 |
| 32771661 | In addition, these vulnerable groups frequently have greater difficulty accessing health services and in treatment adherence. […] Moreover, the reduction seen in follow-up compliance increases the risk of treatment discontinuation and possible relapse. | 2020-08-11 |
| 32771797 | In this review, we summarized the real-time information of 2019-nCoV treatment methods and mainly focused on the chemical drugs including lopinavir/ritonavir, chloroquine, hydroxychloroquine, arbidol, remdesivir, favipiravir and other potential innovative active molecules. […] In addition, Traditional Chinese Medicine (TCM), Convalescent plasma therapy (CPT) and biological reagents available, as well as the promising vaccine candidates against 2019-nCoV are also discussed. | 2020-08-11 |
| 32771883 | Factors predicting survival were a female sex (OR 0.271; 0.128-0.575, p = 0.001), previous treatment with RAAS inhibitors (OR 0.459; 0.222-0.949, p = 0.036), a higher oxygen saturation at admission (OR 0.901; 0.842-0.963 per percentage point increase, p = 0.002), and a greater platelet count (OR 0.995; 0.991-0.999 per 106/L, p = 0.025). […] Previous treatment with RAAS inhibitors, and demographic, clinical and laboratory data influence prognosis. | 2020-08-11 |
| 32771918 | Both patients responded well to treatment and were discharged in a stable condition. | 2020-08-11 |
| 32772007 | With no approved vaccination or therapy available, we found physical distancing and isolation that include public awareness and case-finding and isolation of 40% of infected people could reduce the burden of COVID-19 in Iran by 90% by mid-June. | 2020-08-11 |
| 32772051 | Although the COVID-19 pandemic has largely not clinically affected infants in neonatal intensive care units around the globe, it has affected how care is provided. | 2020-08-11 |
| 32772053 | When we compare our current knowledge of the impact of the pandemic on the development of mental disorders with the findings of research on acute stress disorder (ASD) and posttraumatic stress disorder (PTSD) over the last 40 years, it may turn out that they are different from each other, the symptomatic spectrum of mental disorders varies and the possibilities of an effective treatment are very limited. | 2020-08-11 |
| 32772225 | This US survey of breast cancer survivors characterizes treatment delays early period in the pandemic. […] Forty-four percent of participants reported cancer care treatment delays during the pandemic. […] Delays in all aspects of cancer care and treatment were reported. | 2020-08-11 |
| 32772324 | Severe vitamin D deficiency may be a marker of poor prognosis in these patients, suggesting that adjunctive treatment might improve disease outcomes. | 2020-08-11 |
| 32772343 | The aim of this study was finding the appropriate conditions for the expression of reluctant proteins that is the human neutral amino acid transporters ASCT2 and B0AT1, that have great relevance to human health in cancer therapy and in COVID-19 research, respectively. […] The results have a potentially great interest in drug discovery since ASCT2 is an acknowledged target of anticancer therapy, and B0AT1 together with ACE2 is part of a receptor for the SARS-Cov-2 RBD proteins. | 2020-08-11 |
| 32772412 | Here we detail the background to such countermeasures, present some examples in different settings and finally emphasise that they should remain in place worldwide as a cultural and behavioural “new normal” until a vaccine or a decisive treatment for COVID-19 is developed and made available globally. | 2020-08-11 |
| 32772497 | The new coronavirus has become a global health concern with over 6 million infected and more than 350,000 deaths Researchers around the world are looking for solutions for early detection, monitoring of the evolution of viral infection, for etiological or pathophysiological treatment. | 2020-08-11 |
| 32772627 | However, there is no effective prophylaxis or treatment available for Group 4 viruses. […] Admittedly, the availability of a new vaccine or treatment would change this conclusion, which was reached in the middle of the first pandemic. | 2020-08-11 |
| 32772722 | There has been a surging interest in using elastomeric infusion devices to deliver outpatient parenteral antimicrobial therapy (OPAT), which is more cost-effective than standard antibiotic administration, which requires multiple daily home visits. […] In patients with bloodstream infections, no significant difference was found between the treatment modes (p=.93). | 2020-08-11 |
| 32772743 | The guidelines stress a shared decision-making approach with risk-benefit analysis and treatment strategy modifications tailored to each unique patient case. | 2020-08-11 |
| 32772807 | 4.4% reported changes to therapy plans, primarily delays in infusions, and 15.5% a disruption to rehabilitative services. | 2020-08-11 |
| 32772892 | Although no vaccine or therapeutic treatment has been approved till now for CoV infection, trials of vaccine against SARS CoV-2 are in progress. […] The work focuses on designing of multi-epitope vaccine construct for treatment of seven human CoV infections using the epitopes present on the spike protein of human CoVs. | 2020-08-11 |
| 32773098 | In this review, we will summarize our current knowledge on the thromboembolic manifestations, the disturbed hemostatic parameters, and the thromboinflammatory conditions associated to Covid-19 and we will discuss the modalities of anticoagulant treatment or other potential antithrombotic options. | 2020-08-11 |
| 32773101 | Scientists are scrambling for ideas to develop treatment and prevention strategies to thwart the disease condition. […] In this review, we have attempted to summarize the latest information on the virus, disease, prevention, and treatment strategies. | 2020-08-11 |
| 32773102 | Pandemic coronavirus disease 2019 (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and poses an unprecedented challenge to healthcare systems due to the lack of a vaccine and specific treatment options. | 2020-08-11 |
| 32773103 | In particular, as regards allogeneic (and to a lesser extent autologous) hematopoietic cell transplantation and CAR T-cell therapy, specific recommendations have been issued by the transplant community on the criteria to be used to decide whether or not to postpone these procedures and on the clinical management of recipients and donors exposed to COVID-19. | 2020-08-11 |
| 32773105 | Various types of patients have delayed treatment or even routine check-ups and we are adapting to a virtual world. | 2020-08-11 |
| 32773212 | The unprecedented challenge faced by mankind due to emergence of coronavirus 2019 (COVID-19) pandemic has obligated researchers across the globe to develop effective medicine for prevention and treatment of this deadly infection. […] Short term therapy of remdesivir claimed to be beneficial. […] Food and Drug administration issued only emergency use authorization to remdesivir for the treatment of suspected or laboratory-confirmed COVID-19 in adults and children hospitalized with severe disease. | 2020-08-11 |
| 32773251 | When the health authorities allow the return to normality, and in the absence of an effective treatment for or preventive vaccine against COVID-19 infection, we recommend a strict protocol for classifying patients according to their infectious-contagious status through the appropriate use of tests for the detection of the virus and the immune response to it, and the following of protective measures by the healthcare personnel to prevent contagion during the performance of a gastrointestinal motility test. | 2020-08-11 |
| 32773257 | However, no suitable treatment has found yet. | 2020-08-11 |
| 32773262 | Treatment with hydroxychloroquine or in combination with other medicines did not reduce the quarantine duration. | 2020-08-11 |
| 32773405 | Both sites report that the predominant ethical challenges centered around end-of-life decision making, setting goals of care, and medical futility, all complicated by resource allocation questions and the ambiguity of state law under crisis standards of care. | 2020-08-11 |
| 32773409 | Elucidating the protective mechanisms in children may aid in developing novel treatment strategies. | 2020-08-11 |
| 32773414 | Majority of the patients were managed with supportive treatment with hydroxychloroquine and azithromycin given on a case-to-case basis. | 2020-08-11 |
| 32773727 | Pathophysiology and potential impact on treatment options are discussed. | 2020-08-11 |
| 32773818 | There is currently no vaccine or treatment for COVID-19. […] In terms of treatment, because the immunity of kidney transplant recipients has been suppressed for a long time, it is a very common strategy to suspend the use of immunosuppressive agents. […] Its immunosuppressive and anti-inflammatory effects played a large role in the treatment process.In addition, prophylactic antibiotics was needed, and nephrotoxic drugs should be used with caution. […] Finally, following discounting the use of immunosuppressant and a low-dose glucocorticoid-based treatment regimen, COVID-19 in this renal transplant recipient was successfully cured. […] The cure of this case was of great significance, and this adjuvant nonspecific antiviral therapy could provide a template for the treatment of other such patients. | 2020-08-11 |
| 32773845 | The challenges are not only limited to its preventive strategies, but also extend to curative treatment, and are amplified during the management of critically ill patients with COVID-19. | 2020-08-11 |
| 32773878 | A particular vulnerable group of patients is those with opioid dependence maintained on opioid substitution therapy (OST). […] These patients are pharmacologically dependent on the OST medication (buprenorphine, buprenorphine-naloxone combination [BNX], and methadone) for their healthy functioning and recovery. | 2020-08-11 |
| 32773928 | The social distancing measures seem to have been working for India in absence of treatment in sight for COVID-19. | 2020-08-11 |
| 32773989 | There is at the moment no vaccine or effective treatment for this disease which constitutes a serious global health problem. | 2020-08-11 |
| 32773996 | As the race to develop an effective vaccine intensifies, several clinical trials of antivirals and immune modulators are underway, though no reliable COVID-19-specific therapeutics (inclusive of some potentially effective single and multi-drug regimens) have been identified as of yet. | 2020-08-11 |
| 32774008 | We conducted a systematic review to evaluate the fracture types, presentation, treatment, complications, and early outcomes of fractures occurring amidst COVID-19 pandemic. […] Conservative treatment should be adopted as far as possible in non-obligatory fractures and in lesser equipped centers. | 2020-08-11 |
| 32774178 | To quickly diagnose and control such a highly infectious disease, suspicious individuals were isolated and diagnostic/treatment procedures were developed through patients’ epidemiological and clinical data. […] Early in the COVID-19 outbreak, WHO invited hundreds of researchers from around the world to develop a rapid quality diagnosis, treatment and vaccines, but so far no specific antiviral treatment or vaccine has been approved by the FDA. | 2020-08-11 |
| 32774508 | It was named by the World Health Organization as Coronavirus Disease 2019 (COVID-19), and it garnered unprecedented attention from public health researchers around the world, and studies analyzing chloroquine and hydroxychloroquine as a possible therapy have arisen in the last 2 months. […] Data Synthesis The most typical treatment regimen is 5 days of hydroxychloroquine at daily doses of 400 to 600 mg. […] There is no randomized clinical trial that can prove so far the efficacy of this medication, and few studies have evaluated adverse events potentially linked to their use in patients with COVID-19. […] While there is no concrete evidence on the incidence of ototoxicity using chloroquine in the short term, we need to consider that, as a pandemic disease, millions of patients with COVID-19 may receive this treatment, and ototoxicity can be a possible adverse event. […] Conclusion Despite the urgent global situation caused by the COVID-19, the risk of irreversible hearing loss may outweigh the unproven benefit of using hydroxychloroquine or chloroquine, especially in patients with mild forms of COVID-19, who may be cured with supportive treatment. | 2020-08-11 |
| 32774577 | An interdisciplinary decision for interventional therapy was made. | 2020-08-11 |
| 32774639 | There is currently no vaccine or effective treatment for COVID-19. | 2020-08-11 |
| 32774998 | In traditional Chinese medicine (TCM), the epidemic disease concepts of “febrile epidemics” (wenyi) or “warm diseases” (wenbing) are based on geographic and cultural aspects, and Chinese herbal medicine (CHM) played an important role in the treatment of epidemic diseases. […] We propose the use of CHM treatment principles for clinical practice, based on four main stages of COVID-19 infection: early, intermediate, severe, and convalescence. | 2020-08-11 |
| 32775080 | Even with aggressive antibiotic treatment, the patient remained bacteremic and developed endocarditis with a worsening aortic root abscess. | 2020-08-11 |
| 32775090 | There is no effective, safe treatment for COVID-19. […] In this review, we provide a detailed update on various emerging treatment options and analyze the results of recent trials. | 2020-08-11 |
| 32775372 | This means that these patients require multidisciplinary treatment including early diagnosis, timely transport, emergency surgery and intensive critical care. […] To provide support for the health protection requirements of the medical services in the Neonatal Surgery Department, we developed recommendations focusing on patient transport, surgery selection and protection requirements with the aim of improving treatment strategies for patients and preventing infection in medical staff during the current COVID-19 pandemic. | 2020-08-11 |
| 32775377 | Epidemiological, demographic, clinical, laboratory, and treatment data were collected for analysis. […] Among the 50 patients recruited, no patient has been admitted to intensive care units, and no patient died during the study. | 2020-08-11 |
| 32775378 | Optimizing the diagnosis process, shortening the diagnosis time, and constructing teams of clinical experts facilitated the provision of “one team of medical experts for each patient” treatment for severe patients, which significantly improved the recovery rate and reduced the infection fatality rate. | 2020-08-11 |
| 32775696 | The SEI2RS model considers five strategies for control, namely: large-scale social restriction (u 1), contact tracing (u 2), mass testing (u 3) , case detection and treatment (u 4), and the wearing of face masks (u 5). […] The study concludes that scenario 2, which consists of large-scale social restriction (u1), contact tracing (u2), case detection and treatment (u4), and the wearing of face masks (u5), is the most rational scenario to control COVID-19 spreading in Indonesia. | 2020-08-11 |
| 32775770 | Radiation therapy treatments were resumed on January 30th and have never stopped again at the hospital regardless of the circumstances of the ongoing outbreak. […] Between January 30th and the time of the writing, we have treated over 100 radiation therapy patients, with no incidence of on-site COVID-19 transmission between patients and health care workers in the duration. | 2020-08-11 |
| 32775775 | During the first weeks of the coronavirus disease 2019 (COVID-19) outbreak in France, it was necessary to clearly define organizational priorities in the radiation therapy (RT) departments. […] In this report, we focus on the urgent measures taken to reduce risk for both our staff and patients by reducing the number of patients receiving treatment. […] We reviewed the fractionation schemes for all patients in our department, including those receiving treatment and those soon to start treatment. […] We identified 50 patients who were receiving treatment (n = 6), were going to start radiation after CT scan simulation (n = 41), or for whom the CT scan was pending (n = 3). […] The majority were offered hormone therapy as “waiting therapy.” […] To conserve resources during the pandemic, we successfully reduced the number of patients receiving treatment in a proactive fashion and adapted our organization to minimize the risk of COVID-19 contamination. | 2020-08-11 |
| 32775776 | Perhaps more than any other disease site we commonly see, the evaluation and treatment of head and neck cancer has posed the greatest risk of COVID-19 transmission between patients and radiotherapy providers. | 2020-08-11 |
| 32775777 | Thus, at times treatment decisions might result in delays in initiating therapy, modifying the radiation treatment course (such as to a short course rather than a long course of therapy), and the sequence of therapies, all to minimize viral exposure. […] It is important that altered therapy is based as much as possible on institutional or departmental decisions and, to the extent possible, not on a case-by-case basis. | 2020-08-11 |
| 32775778 | Patients who tested positive for COVID-19 between March 14 and April 15, 2020, at our institution and who previously received radiation therapy for cancer in our department were included in this analysis. […] A logistic model was used to characterize the association between mean lung radiation therapy dose and 14-day mortality risk after COVID-19 diagnosis. […] Increasing mean lung dose (hazard ratio [HR] per Gy = 1.1, P = .002), lung cancer diagnosis (HR = 3.0, P = .034), and receiving radiation therapy between 1 month and 1 year before COVID-19 testing (HR = 3.4, P = .013) were associated with increased risk of death. […] Our survival model demonstrates a near linear relationship between mortality risk after COVID-19 diagnosis and mean lung radiation therapy dose. […] COVID-19 patients with a history of radiation therapy for cancer have a poor prognosis, and mortality risk appears to be associated with extent of lung irradiation. | 2020-08-11 |
| 32775781 | Patients with cancer undergoing radiation therapy (RT) commonly have daily cone beam computed tomography (CBCT) obtained for image-guided RT, and such imaging frequently includes the chest. […] Familiarity with typical CT changes of COVID-19 pneumonitis may allow for early detection in cancer patients undergoing CBCT for RT treatment. | 2020-08-11 |
| 32775783 | Didactic sessions include lectures, case-based discussions, treatment planning seminars, and material adapted from the Radiation Oncology Education Collaborative Study Group curriculum. | 2020-08-11 |
| 32775784 | The pandemic has also increased the use of hypofractionated treatment schedules where magnetic resonance-guided online adaptive radiation therapy (ART) can aid in dose escalation. […] The time from completion of image registration to the beginning of treatment was recorded for 20 fractions before remote-physician ART coverage and 14 fractions after implementation of remote-physician ART coverage. […] Visual quality was calculated using cross-correlation between the treatment delivery and remote-physician computer screens. […] For the 14 fractions after implementation, the average time from image registration to the beginning of treatment was 24.9 ± 6.1 minutes. | 2020-08-11 |
| 32775788 | Mitigation strategies to balance the risk of coronavirus disease 2019 (COVID-19) infection against oncologic risk in patients with breast cancer undergoing radiation therapy have been deployed. […] To this end, shorter hypofractionated regimens have been recommended where appropriate, with prioritization of radiation therapy by oncologic risk and omission or deferral of radiation therapy for lower risk cases. […] Herein, we present our early response and adaptation of breast radiation therapy utilization during the COVID-19 pandemic at a large academic cancer center in Canada. […] To examine our response, the number of weekly breast radiation therapy starts, type of breast radiation therapy, and patient age were compared from March 1 to April 30, 2020 to the same period in 2019. […] After the declaration of emergency in Ontario, there was a decrease of 39% in radiation therapy starts in 2020 compared with 2019 (79 vs 129, P < .001). […] A smaller proportion of patients starting radiation therapy were aged >50 years in 2020, 66% (78 of 118) versus 83% (132 of 160) in 2019, P = .0027. […] A significant reduction in breast radiation therapy starts was noted during the early response to the COVID-19 pandemic, with prioritization of radiation therapy to patients associated with higher oncologic risk requiring RNI. | 2020-08-11 |
| 32775789 | A critical component of this effort is the timely identification of patients undergoing treatment who have COVID-19. | 2020-08-11 |
| 32775790 | Owing to the coronavirus disease 2019 (COVID-19) pandemic, radiation oncology departments have adopted various strategies to deliver radiation therapy safely and efficiently while minimizing the risk of severe acute respiratory syndrome coronavirus-2 transmission among patients and health care providers. […] One practical strategy is to deliver stereotactic body radiation therapy (SBRT) in a single fraction, which has been well established for treating bone metastases, although it has been infrequently used for other extracranial sites. […] A critical review was performed of the articles that described clinical outcomes of single-fraction SBRT for treatment of primary extracranial cancers and oligometastatic extraspinal disease. […] Although single-fraction SBRT is promising for the definitive treatment of other primary or oligometastatic cancers, multi-fraction SBRT should be the preferred regimen owing to the need for additional prospective evaluation to determine long-term efficacy and safety. | 2020-08-11 |
| 32775814 | Approximately 5% of all patients required use of renal replacement therapy (RRT). | 2020-08-11 |
| 32775943 | The explicit lack of standardization of evidence-based maternity care, whether expressed in clinical protocols or institutional policy, has disproportionately impacted marginalized communities. | 2020-08-11 |
| 32775986 | A standard strategy of immunosuppression minimization and treatment was applied, with 11% mortality among kidney transplant recipients hospitalized with COVID-19 infection. | 2020-08-11 |
| 32776139 | Therefore, special considerations should be given to treatment methods for pregnant women with COVID-19. […] Osteopathic manipulative treatment techniques to mitigate the underlying pathology were identified, and modifications for use in pregnancy and the critical care setting are described. | 2020-08-11 |
| 32776243 | The current COVID-19 pandemic is transforming our urologic practice and most urologic societies recommend to defer any surgical treatment for prostate cancer (PCa) patients. […] Multivariable analysis using binary logistic regression and Cox proportional hazard model tested association between surgical delay and upgrading on final pathology, lymph-node invasion (LNI), pathological locally advanced disease (pT3-4 and/or pN1), need for adjuvant therapy, and biochemical recurrence. | 2020-08-11 |
| 32776251 | From the beginning of the SARS-CoV‑2 pandemic the German healthcare system focused on the treatment of COVID-19 patients. | 2020-08-11 |
| 32776298 | Outcomes investigated included in-hospital mortality, intensive care unit (ICU) admission, length of stay, PCR (polymerase chain reaction) negativity and side effects of treatment. […] Median time from symptom onset to treatment initiation was 8 days and was similar between the groups (p = 0.727). […] Side effects led to treatment discontinuation in 15% of patients in the LPV/RTV group. […] Additionally, in comparison to other studies we demonstrated a lower mortality in patients treated with LPV/RTV despite having similar patient groups, perhaps due to early initiation of treatment. | 2020-08-11 |
| 32776309 | A multicenter cohort study was conducted among newborns born to mothers with COVID-19 in 34 neonatal intensive care units (NICUs) in Turkey. | 2020-08-11 |
| 32776534 | To compare the rate of clinical improvement between those who started LPV/ritonavir (LPV/r)+HCQ within 5 days of symptom onset (early treatment, ET) and those who started later (delayed treatment, DT). […] The association between the timing of treatment and the probability of 30-day mortality was assessed using univariable and multivariable logistic models. […] After adjusting for potentially relevant clinical variables, there was no significant association between the timing of the start of treatment and the probability of 30-day mortality (adjusted odds ratio [aOR] ET vs DT = 1.45, 95% confidence interval 0.50-4.19). […] Eight percent of the patients discontinued the treatment becausebecause of severe gastrointestinal disorders attributable to LPV/r. […] The timing of the start of LPV/r + HCQ treatment does not seem to affect the clinical course of hospitalized patients with COVID-19. | 2020-08-11 |
| 32776573 | In the absence of definitive therapy for coronavirus disease (COVID-19), convalescent plasma therapy (CPT) may be a critical therapeutic option. | 2020-08-11 |
| 32776624 | Tocilizumab, an interleukin-6 inhibitor, has been trialled for treatment of CRS in COVID-19, but not yet approved. | 2020-08-11 |
| 32776805 | The sudden outbreak of severe acute respiratory syndrome coronavirus 2 pneumonia posed a significant challenge to medical professionals because treatment of critically ill patients requires the efforts of a multidisciplinary team. | 2020-08-11 |
| 32777212 | Several clinical studies are being performed to test possible drugs in response to the COVID-19 outbreak; however, there is still no treatment that is completely effective. | 2020-08-11 |
| 32777268 | While POS caused alarm and reduced tolerance to therapy, this phenomenon resolved over a median of 17 days with improvement of parenchymal disease. | 2020-08-11 |
| 32777300 | Another concern is the lack of definitive treatment for this disease. […] The researchers tried different treatment options which are not specific. […] The result indicates that simeprevir (Hepatitis C virus NS3/4A protease inhibitor) and pyronaridine (antimalarial agent) could fit well to the binding pocket of the main protease and because of some other beneficial features including broad-spectrum antiviral properties and ADME profile, they might be a promising drug candidate for repurposing to the treatment of COVID-19. […] Simeprevir and pyronaridine were selected by the combination of virtual screening and molecular dynamics simulation approaches as a potential candidate for treatment of COVID-19. | 2020-08-11 |
| 32777318 | Although new skin manifestations caused by COVID-19 are continuously being described, other cutaneous entities should also be considered in the differential diagnosis, including adverse cutaneous reactions to drugs used in the treatment of COVID-19 infections. | 2020-08-11 |
| 32777322 | Previously developed models were adapted for 110 countries to include a status quo or “no delay” scenario and a “1-year delay” scenario assuming significant disruption in interventions (screening, diagnosis and treatment) in the year 2020. […] In order to mitigate the impact on viral hepatitis programming and reduce excess mortality from delayed treatment, policy makers should prioritize hepatitis programs as soon as it becomes safe to do so. | 2020-08-11 |
| 32777401 | Infectious disease, pulmonology, and intensive care units have been strengthened and expanded. […] The profound effects on spine surgery call for systematic approaches to optimizing the diagnosis and treatment of spinal diseases. | 2020-08-11 |
| 32777488 | We found high percentages of men (63%), open wounds (70%), domestic accidents (88%) and surgical treatment being required (76%). | 2020-08-11 |
| 32777745 | In the last decades DMTs have been widely employed, and ocrelizumab represents one of the newest therapies for the relapsing remitting and progressive forms of multiple sclerosis (MS). to describe SARS-CoV-2 related pneumonia in two MS patients under ocrelizumab treatment. […] Ocrelizumab treatment is not necessarily associated to increased severity in MS patients with SARS-CoV-2 infection. | 2020-08-11 |
| 32777758 | The incidence of renal replacement therapy (RRT) is variable, ranging from 0-37%. | 2020-08-11 |
| 32777784 | The patients were divided into three groups according to their liver status during treatment. […] Liver injury was detected in 75 (50.7%) and 93 (63%) patients by admission and during treatment respectively. | 2020-08-11 |
| 32777902 | For this reason, melatonin supplementation in elderly could be beneficial in COVID-19 treatment. […] Therefore, studies on the usage of melatonin in COVID-19 treatment are needed. | 2020-08-12 |
| 32778033 | We also reviewed the probable mechanism of using ACE2 in viral attachment and the probable treatment processes will also be discussed based on the surface proteins of the virus and ACE2. | 2020-08-12 |
| 32778174 | Data of 402 cancer patients undergoing active treatment from February 24 to April 24, 2020 were retrospectively reviewed; several indicators of the Department functioning were also analyzed. […] Decrease of radiotherapy treatment number reached 17%, while the number of administration of systemic treatment and follow up evaluations kept constant. […] Conversely, new treatment planning faced substantial decline. […] Considering only the last month, infection rate among patients undergoing treatment precipitated to 0.43% (1/232) and no new contagions were reported within our staff. […] Although mortality rate in COVID-19 cancer patients is elevated, our results support the feasibility and safety of continuing anticancer treatment during SARS-Cov-2 pandemic by endorsing consistent preventive measures. | 2020-08-12 |
| 32778359 | Key identified areas of consideration when offering telemedicine included (1) how to set up and structure a telemedicine visit and maintain patient confidentiality, (2) patient examination and treatment initiation, (3) optimization of the tele-visit, (4) limitations and recognition of when a tele-visit is insufficient for patient care needs, (5) billing/reimbursement considerations. | 2020-08-12 |
| 32778421 | Up until now, no specific treatment has yet been proven effective against SARS-CoV-2. | 2020-08-12 |
| 32778622 | It is overlapping the curative or treatment strategies as it is states “to cure is to prevent”. […] In 2020, in which each underlying conditions require effective treatment and each disease should be prevented. | 2020-08-12 |
| 32778631 | Oncology patients even have a worse prognosis with greater infection susceptibility because they are in a state of suppression of the systemic immune system due to malignancy and anticancer therapy. […] This problem makes adequate and appropriate treatment urgently needed. […] She was undergoing hormone therapy but experiencing disease progression after achieving complete remission based on PET-CT scan 4 months before. | 2020-08-12 |
| 32778634 | Uncertain treatment for this viral infection increases excessive anxiety, which does not occur only in one person but also in majority of people; therefore, it can create mass panic. | 2020-08-12 |
| 32778886 | Early recognition is important to administer immunomodulatory therapy which may be life saving for these patients. | 2020-08-12 |
| 32778950 | In this review, we elaborate all currently available data that shed light on possible methods for treatment of COVID-19, such as antiviral drugs, corticosteroids, convalescent plasma, and potentially effective vaccines. | 2020-08-12 |
| 32778962 | There are numerous protein kinases associated with these processes that can be inhibited by FDA-approved drugs, the repurposing of which presents an alluring option as they have been thoroughly vetted for safety and are more readily available for treatment of patients and testing in clinical trials. | 2020-08-12 |
| 32779213 | Therefore, a direct delivery of hydroxyderivatives of vitamin D deserves consideration in the treatment of COVID-19 or ARDS of different aetiology. […] We also recommend treatment of COVID-19 patients with high-dose vitamin D since populations most vulnerable to this disease are likely vitamin D deficient and patients are already under supervision in the clinics. | 2020-08-12 |
| 32779280 | We described patient demographics, the therapy received by the patient and the characteristics of each pattern. | 2020-08-12 |
| 32779305 | The world is in an immediate need of treatment for coronavirus disease (COVID-19). […] Chronic exposure of hydroxychloroquine in the treatment of COVID-19 may have multiple adverse effects on human physiology, such as cardiac arrhythmias. […] Natural compounds need to be evaluated as treatment and preventive agents in coronavirus infection. […] Results indicated (a) curcumenol, (b) N-desmethylselegiline, (c) phentermine and (d) sphingolipid derivatives as a selective and potent candidates in comparison to hydroxychloroquine for COVID-19 treatment. | 2020-08-12 |
| 32779309 | This article will benefit the treatment and prognosis of fetuses and newborns of SARS-CoV-2-infected pregnant women. | 2020-08-12 |
| 32779326 | Moreover, the observed discrepancies might also result from differences in the clinical inclusion criteria, including the possibility of early treatment that may be essential for therapy efficacy in patients with Covid-19. […] Successful treatment will probably be based on multitherapies with antiviral compounds that target different steps of the virus life cycle. […] Finally, large retrospective studies on hospitalized patients are needed to evaluate the different treatments with robust statistical tools and to identify the best treatment for each Covid-19 stage. | 2020-08-12 |
| 32779341 | No effective treatment is yet in sight for this catastrophic illness. […] Immunomodulatory agents like hydroxychloroquine (HCQ) as well as biological disease-modifying anti-rheumatic drugs (bDMARDs) such as tocilizumab and anakinra received worldwide attention for treatment of critical patients with COVID-19. | 2020-08-12 |
| 32779446 | The goal of IBD treatment is to reduce the inflammation period and induce long-term remission. […] Use of anti-inflammatory drugs including corticosteroids, immunosuppressants and biologicals, is often the first step in the treatment of IBD. […] This might be because of particular anti-TNF-α treatment or any immunosuppressant that IBD patients receive. | 2020-08-12 |
| 32779465 | Due to the lack of ophthalmological approaches to the treatment of such patients, different management tactics are given based on the severity of local and systemic disease manifestations. | 2020-08-12 |
| 32779705 | Convalescent plasma (CP) is a potentially important therapy for coronavirus disease 2019 (COVID-19). | 2020-08-12 |
| 32779728 | The primary outcome is days alive without life support (ie mechanical ventilation, circulatory support, and renal replacement therapy) at day 28. | 2020-08-12 |
| 32779737 | Hypercytokines cause acute respiratory distress syndrome (ARDS) in coronavirus disease 2019 (COVID-19) patients, which is the main reason for intensive care unit treatment and the leading cause of death in COVID-19 patients. […] This study evaluated the efficacy and safety of Oxiris filter in the treatment of COVID-19 patients. […] Five patients with COVID-19 who received continuous renal replacement therapy (CRRT) in Henan provincial people’s hospital between January 23, 2019 and March 28, 2020, were enrolled in this study. […] After treatment, HR (101.4 ± 14.08 vs. […] No adverse events occurred during the treatment. […] Our study observed a reduced level of overexpressed cytokines, stabilization of hemodynamic status, and staged improvement of organ function during the treatment with Oxiris filter. | 2020-08-12 |
| 32779744 | These data will provide a theoretical basis for clinical diagnosis and treatment. | 2020-08-12 |
| 32779748 | In this editorial perspective, we (a) provide data on COVID-19 pandemic-related psychopathology in children and adolescents from a large psychiatric treatment setting in Denmark, (b) give advice on how the likely harmful effects of the COVID-19 pandemic on the mental health of children and adolescents may be minimized, and (c) propose six lines of research into pandemic-related psychopathology with emphasis on children and adolescents. | 2020-08-12 |
| 32779755 | In this descriptive observational study, we aimed to discuss the treatment response of HCQ in COVID-19 infected patients and 30 cases were included. […] The demographic, treatment, laboratory parameters of C-reactive protein (CRP) and interleukin-6 (IL-6) before and after HCQ therapy and clinical outcome in the 30 COVID-19 patients were assessed. […] We found that, the elevated IL-6, a risk factor in severe patients were reduced to normal level after HCQ treatment. | 2020-08-12 |
| 32779768 | He had no past medical history (no chronic diseases or medication) or any symptoms of COVID-19; however, his brother reported that his roomate was diagnosed with COVID-19 one day prior and went to a protective isolation institution. | 2020-08-12 |
| 32779770 | However, no studies have reported an association between corrected QT (QTc) prolongation and antiviral therapy in patients with novel coronavirus disease (COVID-19). […] We present two cases from our institution in which patients with COVID-19 experienced QTc prolongation during treatment with antiviral therapy. […] Careful analysis of electrocardiograms for QTc duration should be performed at baseline and during antiviral therapy to identify individuals at high risk of arrhythmias. | 2020-08-12 |
| 32779784 | Mutational changes in amino acids are predicted to alter the structure and function of the corresponding proteins, thereby, it is imperative to consider the mutational spectra while designing new antiviral therapeutics targeting viral orf1ab. | 2020-08-12 |
| 32779820 | In this study, we aimed to conduct a systematic review on COVID-19 clinical manifestations and treatment strategies in SOT recipients. […] There are different treatment strategies, but in most of them, antimetabolite and Calcineurin inhibitors were decreased or discontinued, while corticosteroids were increased. | 2020-08-12 |
| 32779822 | These symptomatic patients all recovered after antibacterial combined with antifungal treatment, but without any antiviral agents. | 2020-08-12 |
| 32779823 | Whereas the oncology societies favored a more or less conservative approach which considered the possibility of delaying treatment administration on a case-by-case basis, the hematology community guidelines were less stringent and recommended adequate individualized regimens. | 2020-08-12 |
| 32779824 | Here, the feasibility, advantages, and disadvantages of a therapy based on oral administration of possible volatile drugs for COVID-19 will be discussed. […] Both aerosolized antiviral therapy and oral intake of volatile molecules are briefly reviewed, and an evaluation of 1,8-cineole is provided in view of a possible clinical use and also for asymptomatic COVID-19. | 2020-08-12 |
| 32779848 | Our neurology department at Xuanwu Hospital in Beijing is one of the national centers for the research and treatment of neurological disorders in China. | 2020-08-12 |
| 32779878 | The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-caused coronavirus disease 2019 (COVID-19) pandemic has become a global health crisis with an extremely rapid progress resulting in thousands of patients requiring intensive care unit (ICU) treatment who may develop acute respiratory distress syndrome (ARDS). | 2020-08-12 |
| 32779917 | Due to the poor prognosis, care for patients with progressive disease during neoadjuvant systemic therapy and a triple negative, may not be postponed. […] In certain groups of patients, including those with ductal carcinoma in situ or an endocrine sensitive tumour, treatment may be postponed or modified, although with certain reservations.At the initiative of the NationaalBorstkankerOverleg Nederland, prospective data are currently being collected in order to gain more insight into the impact of COVID-19 on breast cancer care. | 2020-08-12 |
| 32780011 | The study objective was to examine the effect of COVID-19 on treatment adherence and self-reported sleep duration among patients with Obstructive Sleep Apnea (OSA) treated with positive airway pressure (PAP) therapy. | 2020-08-12 |
| 32780229 | Many concerns still exist regarding the safety of hydroxychloroquine (HCQ) in the treatment of Coronavirus Disease 2019 (COVID-19). […] The purpose of this study was to evaluate the safety of HCQ in the treatment of COVID-19 and other diseases by performing a systematic review and meta-analysis. | 2020-08-12 |
| 32780290 | Beyond the pathogenesis of SARS-CoV-2, microbial coinfection plays an important role in the occurrence and development of SARS-CoV-2 infection by raising the difficulties of diagnosis, treatment, prognosis of COVID-19, and even increasing the disease symptom and mortality. […] • Microbial coinfection exacerbates the processes of the occurrence, development and prognosis of COVID-19, and the difficulties of clinical diagnosis and treatment. | 2020-08-12 |
| 32780294 | More than a third of participants reported social distancing themselves (38.3%), and 28.8% reported obtaining prescription medication to prepare for the outbreak. […] Individuals with low health literacy were less likely to report obtaining medication supplies. | 2020-08-12 |
| 32780299 | The immunomodulatory effect of mesenchymal stem cells (MSCs) as the alternative therapy for the treatment of inflammatory and autoimmune diseases is well known. | 2020-08-12 |
| 32780300 | Decisions regarding initiation or continuation of disease-modifying therapy for multiple sclerosis have to consider the potential relevance to the pandemic. […] The infectious side-effect profile as well as the route and frequency of administration of each therapeutic agent should be carefully considered when selecting a new treatment or deciding on risk mitigation strategies for existing therapy. […] More importantly, the impact of each agent on the future severe acute respiratory syndrome coronavirus type-2 (SARS-CoV-2) vaccine should be carefully considered in treatment decisions. […] However, moderate and highly active multiple sclerosis will continue to require treatment with oral or intravenous high-potency agents but a number of risk mitigation strategies may have to be implemented. […] Patients with iatrogenic hypogammaglobulinemia may require prophylactic intravenous immunoglobulin therapy in certain situations. […] We propose risk mitigation strategies and practical approaches to disease-modifying therapy during the COVID-19 pandemic. | 2020-08-12 |
| 32780426 | Treatment prioritization tools have shown benefit in helping to triage patients equitably with minimal provider cognitive burden. | 2020-08-12 |
| 32780518 | We defined inpatients with severe COVID-19 as those requiring admission to the Intensive Therapy Unit (ITU). | 2020-08-12 |
| 32780765 | Hospitalization risk was increased with older age, black race, male sex, former smoking history, diabetes, hypertension, chronic lung disease, poor socioeconomic status, shortness of breath, diarrhea, and certain medications (NSAIDs, immunosuppressive treatment). | 2020-08-12 |
| 32780793 | Participants were isolated in a community treatment center in Cheonan, Republic of Korea. […] In this cohort study of symptomatic and asymptomatic patients with SARS-CoV-2 infection who were isolated in a community treatment center in Cheonan, Republic of Korea, the Ct values in asymptomatic patients were similar to those in symptomatic patients. | 2020-08-12 |
| 32780853 | This case report describes a 42-year-old male with COVID-19 who developed a massive pulmonary embolism resulting in cardiac arrest after suspected failure of low-molecular-weight heparin therapy for a deep venous thrombosis. […] Administration of two 50-mg doses of intravenous alteplase resulted in return of spontaneous circulation, and low-dose argatroban was used as follow-up anticoagulation therapy without complications. […] Argatroban may be used as an alternate anticoagulation strategy in COVID-19 patients who fail low-molecular weight therapy. […] A risk versus benefit discussion should be had regarding appropriateness of therapy as well as dosing. […] More data is needed to understand the unique hypercoagulable condition in COVID-19 patients as well as research that further highlights the role of argatroban and bivalirudin therapy in this patient population. | 2020-08-12 |
| 32780854 | Symptoms disappeared a few days after commencement of treatment (prednisone in 3 patients and ibuprofen in 1). | 2020-08-12 |
| 32780893 | Moreover, high-dose intravenous NAC may be expected to play an adjuvant role in the treatment of severe COVID-19 cases and in the control of its lethal complications, also including pulmonary and cardiovascular adverse events. | 2020-08-12 |
| 32780961 | This study aimed to shed light on physicians’ knowledge of potential DDIs related to COVID-19 treatment, to determine the effect of an information brief about these DDIs on their correct response rates, and to identify factors associated with higher levels of knowledge about these DDIs. […] The knowledge of physicians regarding the clinical significance and intervention of 7 common potential DDIs during COVID-19 treatment was evaluated via an online survey. […] A total of 244 physicians participated in the survey, 147 (60.2%) of whom were involved in the treatment of COVID-19 patients. […] In comparisons of pretest knowledge, physicians involved in the treatment of COVID-19 patients showed significantly higher correct response rate for interventions compared to physicians who had not treated COVID-19 patients (p = 0.003). […] Physicians involved in the treatment of COVID-19 patients had more knowledge regarding clinical significance and appropriate management of potential DDIs than those not involved. | 2020-08-12 |
| 32781034 | Prospective, multicenter, observational study, in 19 pediatric intensive care units. […] Demographic, clinical-epidemiological features, treatment, and outcomes were collected. […] In Brazilian pediatric intensive care units, COVID-19 had low mortality, age less than 1 year was not associated with a worse prognosis, and patients with multisystemic inflammatory syndrome had more severe symptoms, higher inflammatory biomarkers, and a greater predominance of males, but only comorbidities and chronic diseases were independent predictors of severity. | 2020-08-12 |
| 32781230 | Globally, there has been a rapid proliferation of research studies and clinical trials assessing risks, infectivity and treatment. | 2020-08-12 |
| 32781247 | Historically, the standard of care for total skin electron beam therapy (TSEBT) delivered 30 to 36 Gy over 5 to 10 weeks. […] Cumulative incidence of subsequent treatment was 28.0% at 3 months, 46.8% at 6 months, and 70.0% at 1 year. […] Patients who underwent repeat courses of HTSEBT continued to have similar treatment responses to repeat courses without increased toxicities. […] HTSEBT allows therapy to be completed in far fewer treatments. […] Low-dose HTSEBT is an appropriate treatment option for patients unable to come for daily treatment. | 2020-08-12 |
| 32781283 | After 14 days of treatment, there was no significant difference in the improvement rate of clinical symptoms among the three groups (P > 0.05). […] Huoxiang Zhengqi dropping pills combined with Lianhua Qingwen granules has advantages in the treatment of nausea, vomiting and limb soreness. […] During treatment, all participants were treated with western medicine, and there was a significant difference in the use of macrolides among the three groups (P < 0.05). | 2020-08-12 |
| 32781471 | We aimed to report the impact of the pandemic lockdown period on the treatment and prognosis of superficial gastrointestinal neoplastic lesions. | 2020-08-12 |
| 32781614 | Lastly, the latest evidence on pharmacological treatment is summarised. | 2020-08-13 |
| 32781617 | In this review, we have systematically summarized the epidemiological studies, clinical features, biological properties, diagnostic methods, treatment modalities, and preventive measurements related to COVID-19. | 2020-08-13 |
| 32781623 | The clinical, laboratory, radiologic, and pathologic findings, therapy and outcomes in COVID-19 patients presenting with intracranial bleeding were analyzed. | 2020-08-13 |
| 32782044 | The present consideration statement summarizes current strategies on pre-diagnosis, triage, diagnosis, treatment, and prevention of 2019-nCoV infection, which provide practical suggestions on strengthening the management of pediatric fever clinics during the novel coronavirus pneumonia epidemic period. | 2020-08-13 |
| 32782047 | The clinical laboratory center of Leishenshan Hospital (CLCLH) was constructed at the same time within 11 days to support the treatment of inpatients in Leishenshan Hospital and the testing of suspected patients from different fever clinics in Wuhan. | 2020-08-13 |
| 32782059 | In order to increase the likelihood of successfully managing future events, it is important to consider preexisting health security, valid population-based management approaches, medical decision-making, communication, continuous assessment, triage, treatment, early and complete physical distancing strategies, and logistics. […] There is a need for innovative and regular educational activities for all stakeholders committed to safeguarding our future defense systems concerning diagnostic, protection, treatment, and rehabilitation in pandemics, as well as other emergencies. | 2020-08-13 |
| 32782109 | This study aims to compare and analyze the clinical outcomes and characteristics of confirmed and clinically diagnosed COVID-19 patients to determine whether they are of the same type and require equal treatment. […] They are of the same type and require equal treatment. | 2020-08-13 |
| 32782110 | Patients with previous treatment with RAS inhibitor (42.4%) showed lower risk of the primary composite endpoint (mortality or need for invasive mechanical ventilation). […] Treatment with RAS inhibitor (both outpatient treatment and during hospitalization) had neither effect on mortality nor need for invasive ventilation. […] RAS inhibitor treatment prior to admission in patients with COVID-19 respiratory infection was associated with lower risk of the primary composite endpoint and did not show neither impact on mortality nor need for invasive mechanical ventilation, even if these drugs were prescribed during hospitalization. | 2020-08-13 |
| 32782493 | The present review presents the most promising repurposed regimens, which may be used for the treatment of COVID-19. | 2020-08-13 |
| 32782767 | An efficient pharmacological treatment for COVID-19 is not ready yet; in the meanwhile, a general quarantine has been initiated as a preventive action against the spread of the disease. | 2020-08-13 |
| 32782814 | The rapid worldwide spread of COVID-19 has posed a serious threat to patients treated with kidney replacement therapy (KRT). | 2020-08-13 |
| 32782815 | With all the uncertainty during this time, it is hopeful to hear many promising COVID-19 treatments being researched, one of them being a PD drug therapy, amantadine. | 2020-08-13 |
| 32782898 | This concerns the correct procedure for the use of personal protective materials as well as process adjustment for parallel treatment of positive and negative patients in the central OR, and handling of aerosols in the operating theater, operating room, and surgical site under consideration of staff and patient protection. | 2020-08-13 |
| 32782914 | However, the management of other disease states may require some patients to undergo outpatient parenteral antimicrobial therapy (OPAT). […] These include shortening durations of therapy, utilizing the oral route, avoiding medications requiring therapeutic drug monitoring, selecting antimicrobials with long durations, decreasing frequency of laboratory blood draws, and performing tele-health visits. | 2020-08-13 |
| 32783196 | Presently, the pivotal role of H2 S in modulating the inflammatory response and pro-inflammatory cytokine cascade is well recognized, and the usefulness of some H2 S-donors for the treatment of acute lung inflammation has been reported. […] Therefore, repurposing of H2 S-releasing drugs may be a potential therapeutic opportunity for treatment of COVID-19. | 2020-08-13 |
| 32783247 | The main 3-chymotrypsin-like cysteine protease (3CLPro) enzyme of SARS-CoV-2, which operates its replication, could be used as a medication discovery point. | 2020-08-13 |
| 32783337 | Treatment performance indicators were tested by chi-squared test for proportions, and by Student’s t-test or Mann-Whitney test for continuous variables. | 2020-08-13 |
| 32783352 | The interaction of nanomaterials and microorganisms is considered as a potential treatment method because the nanomaterials owe unique physicochemical properties. | 2020-08-13 |
| 32783511 | The anti-infection protocol divided patients into 3 categories, namely outpatients, inpatients, and patients receiving radiation therapy at our cancer center, and each category had a distinct anti-infection protocol to minimize the risk of Coronavirus disease 2019 transmission. […] We found that the total volume of both outpatient visits and inpatient treatment declined significantly depending on the conditions of each group. […] Radiation therapy and palliative service had the lowest and highest volume reductions at 58.3% and 100%, respectively. […] The decline in outpatient volumes was higher than the decline in inpatient treatment services (78.8% vs 71.8%). | 2020-08-14 |
| 32783586 | Currently, all the attention of research centers and governments globally are focused on the investigation of vaccination studies and the discovery of small molecules that inhibit the SARS-CoV-2 virus in the treatment of patients. | 2020-08-14 |
| 32783643 | In the absence of an effective vaccine or any definitive cure, the use of host-directed therapies is an effective alternative and demanding treatment option in the current pandemic outbreak of COVID-19. | 2020-08-14 |
| 32783675 | Increased risk of transmission has been associated with aerosol generating procedures that include endotracheal intubation, bronchoscopy, open suctioning, administration of nebulized treatment, manual ventilation before intubation, turning the patient to the prone position, disconnecting the patient from the ventilator, noninvasive positive-pressure ventilation, tracheostomy, and cardiopulmonary resuscitation. | 2020-08-14 |
| 32783758 | Finally, the potential use of ACE2 as a treatment target in COVID-19, despite its role to allow viral entry into host cells, is suggested. | 2020-08-14 |
| 32783794 | Claims were related to illness, transmission and mortality (24%), control measures (21%), treatment and cure (19%), cause of disease including the origin (15%), violence (1%), and miscellaneous (20%). | 2020-08-14 |
| 32783878 | Influent and secondary-treated (before chlorination) wastewater samples and river water samples were collected five times from a wastewater treatment plant and three times from a river, respectively, between March 17 and May 7, 2020. | 2020-08-14 |
| 32783916 | We also observe ADP-Mg2+ bound in the nsp12 N-terminal nidovirus RdRp-associated nucleotidyltransferase domain, detailing a new pocket for anti-viral therapy development. | 2020-08-14 |
| 32784217 | In this retrospective case series, clinical outcomes and correlates of response to treatment with the IL-6 receptor antagonist sarilumab are described for 15 patients with COVID-19 from a single institution in Southern Italy. […] Among 10 patients whose symptoms improved after sarilumab treatment, rapid decreases in CRP levels corresponded with clinical improvement. […] Lower levels of IL-6 at baseline as well as lower neutrophil to lymphocyte ratio as compared with patients whose COVID-19 did not improve with treatment were associated with sarilumab-responsive disease. […] This observation may reflect a possible clinical benefit regarding early intervention with IL-6-modulatory therapies for COVID-19 and that CRP could be a potential biomarker of response to treatment. | 2020-08-14 |
| 32784242 | His neurological symptoms improved significantly after treatment with intravenous methylprednisone. | 2020-08-14 |
| 32784243 | He improved with anticoagulation and antiepileptic therapy. | 2020-08-14 |
| 32784499 | Pharmaceutical companies and academic researchers are relentlessly working to investigate experimental, repurposed or FDA-approved drugs on a compassionate basis and novel biologics for SARS-CoV-2 prophylaxis and treatment. | 2020-08-14 |
| 32784543 | Efforts to find a treatment for COVID-19 has fueled a recent surge in interest in chloroquine/hydroxychloroquine and its effects. | 2020-08-14 |
| 32784601 | Subjects in high-risk groups should have high priority as regards this nutritive adjuvant therapy, which should be started prior to administration of specific and supportive medical measures. | 2020-08-14 |
| 32784922 | Nowadays, one of the critical issues still to be pointed out regards COVID-19 treatment regimens and timing: which drug, in which phase, for how long? […] Methods: Our narrative review, developed using MEDLINE and EMBASE, summarizes the main evidences in favor or against the current proposed treatment regimens for COVID-19, with a particular focus on antiviral agents. […] Results: Although many agents have been proposed as possible treatment, to date, any of the potential drugs against SARS-CoV-2 has shown to be safe and effective for treating COVID-19. | 2020-08-14 |
| 32785021 | Appendicular and total lean mass (ASM; +3%, TLM; +2%), lean mass to fat ratios (ASM/% body fat; +6%, TLM/% body fat; +5%), maximal strength (grip; +8%, leg press; +17%), and function (5-Times Sit-to-Stand time; -9%) were significantly improved in the M5 group following HBRE/MIS therapy (pre vs. post tests; p < 0.05). […] Sub-group analysis indicated even greater gains in total lean mass in sarcopenic individuals following HBRE/MIS therapy (TLM; +1.65 kg/+3.4%, p < 0.05). | 2020-08-14 |
| 32785121 | However, nutritional therapy appears as first-line treatment and should be implemented into standard practice. | 2020-08-14 |
| 32785285 | A model for predicting intensive care unit admission or death with excellent discrimination was created that may aid in treatment decisions and resource allocation. | 2020-08-14 |
| 32785687 | Although disrupting the viral life cycle is critical for limiting viral spread and disease, it has proven challenging to develop targeted and selective therapeutics. | 2020-08-14 |
| 32785710 | Patients in the MP arm tended to need more insulin therapy, and no difference was seen in virus clearance in respiratory secretion until day 7. | 2020-08-14 |
| 32785756 | Some otolaryngology healthcare workers in Hubei province experienced anxiety during the epidemic, but most of them did not receive treatment. | 2020-08-14 |
| 32785855 | Lung ultrasound is a point-of-care imaging tool that proved to be useful in the identification and severity assessment of different pulmonary conditions, particularly in the setting of emergency and critical care patients in intensive care units; HRCT of the thorax is regarded as the mainstay of imaging evaluation of lung disorders, enabling characterization and quantification of pulmonary involvement. | 2020-08-14 |
| 32785899 | The survey consisted of 16 questions on the local COVID-19 case numbers, protective measures, procedural instructions and treatment concepts. […] Test results influenced decisions on treatment in 71.2% of the clinics. […] The applied procedural instructions as well as the effects of COVID-19 on treatment decisions and patient-doctor contact differed between the reporting clinics. | 2020-08-14 |
| 32785928 | He had progressed to first-line therapy for CRPC with abiraterone plus androgen-deprivation therapy (ADT) and as second-line therapy he was being treated with docetaxel, with biochemical progression in his last prostate specific antigen measurement. | 2020-08-14 |
| 32786117 | The population infected with SARS-CoV-2 requiring an intensive care unit admission often requires nutrition therapy as part of supportive care. […] This article offers relevant and practical recommendations on how to optimize nutrition therapy in critically ill patients with COVID-19. | 2020-08-14 |
| 32786152 | Whether kidney transplant recipients are capable of mounting an effective anti-severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) adaptive immune response despite chronic immunosuppression is unknown and has important implications for therapy. […] The findings raise the possibility that empiric reductions in immunosuppressive therapy for all kidney transplant recipients with active COVID-19 may not be required. | 2020-08-14 |
| 32786284 | Artemisinins are a cluster of artemisinin-related drugs developed for the treatment of malaria and have been reported to have multiple pharmacological activities, including anticancer, antiviral, and immune modulation. | 2020-08-14 |
| 32786401 | The only current FDA-approved treatment, which directly targets the virus, is the ProTide prodrug remdesivir. | 2020-08-14 |
| 32787225 | Unravelling the mechanisms of Furin action, binding dynamics, and the genetic variants opens the growing arena of bona fide antibodies and development of potential therapeutics targeting the blockage of Furin cleavage. | 2020-08-14 |
| 32787328 | Overall, this work expands our knowledge of small-molecule treatment against COVID-19 and provides a general screening pathway (combining quick ML models with expensive high-fidelity simulations) for targeting several chemical/biochemical problems. | 2020-08-14 |
| 32787373 | The diagnostic and classification criteria were based on the 7th edition of Diagnosis and Treatment Guideline of COVID-19 published by the National Health Commission of the People’s Republic of China. | 2020-08-14 |
| 32787378 | The patient was a 24-year-old male who was diagnosed with HIV infection 2 years ago and then followed a regular antiretroviral therapy (ART). […] After standard treatment by 9 days, the patient was cured and discharged. | 2020-08-14 |
| 32787379 | In the last decade we have been able to identify key molecular features that have provided us with greater insight into the behavior of these tumors, but the spectrum of treatment options remains limited. […] This review aims to discuss prognostication in low grade versus high grade gliomas, variability in treatment of these tumors, clinical features of poor prognosis, and differences in prognostic understanding between patients, caregivers, and providers. […] We will also make some general recommendations where appropriate on how to approach this subject from a palliative care perspective. | 2020-08-14 |
| 32787389 | To address some of the pertinent issues with these assessments, the end-of-life decision-making capacity of a 72-year-old female with treatment-resistant schizophrenia and terminal cancer is discussed, as are the role of the treating clinician and the importance of health-related values. […] This implies that the decision-making capacity of the patient is only practically important when the treatment team is willing to proceed against the patient’s wishes. […] This shifts the focus from a potentially difficult assessment to the simpler question of whether the patient’s capacity will change the treatment approach. […] Compared to the general populations people with serious mental illness (SMI) have higher rates of physical illness and die at a younger age, but they do not commonly access palliative care services. […] More research about palliative care and advance care planning for people with SMI is needed. | 2020-08-14 |
| 32787397 | The treatment of severely ill coronavirus disease 2019 (COVID-19) patients has brought the worldwide shortage of oxygen and ventilator-related resources to public attention. […] Most patients need oxygen and supportive therapy. | 2020-08-14 |
| 32787399 | Infection prevention in older persons in Nigeria will far outweigh the possibilities of treatment given limited resources. | 2020-08-14 |
| 32787442 | The Covid-19 pandemic has caused changes in the surgical treatment of non-Covid patients, especially in thoracic surgery because most procedures are aerosol generating. | 2020-08-14 |
| 32787470 | These observations could be reinforced by the more and more evident existence of a lung-gut axis, suggesting the modulation of gut microbiota among the approaches to the COVID-19 prevention and treatment. | 2020-08-14 |
| 32787701 | Background The prognosis of hospitalized patients with severe coronavirus disease 2019 (COVID-19) is difficult to predict, while the capacity of intensive care units (ICUs) is a limiting factor during the peak of the pandemic and generally dependent on a country’s clinical resources. | 2020-08-14 |
| 32787748 | Therefore, it may be hypothesized that early treatment of COVID-19 patients with pentoxifylline, alone or in combination with oxypurinol, would prevent the potentially lethal acute respiratory distress syndrome. | 2020-08-14 |
| 32787752 | Furthermore, ribavirin may also be a potential treatment against CHIKV; sofosbuvir against ZIKV; celgosivir against DENV, and favipiravir against EBOV and MARV, representing new hopes against these pathogens. | 2020-08-14 |
| 32787771 | The coronavirus disease 2019 (nCOV-2019) has created mass panic in China due to its highly contagious by contact and aerosols and lack of effective treatment. | 2020-08-14 |
| 32787782 | We consider handling missing data arising due to (i) participant infection, (ii) treatment disruptions and (iii) loss to follow-up. […] We consider both settings where treatment effects for a ‘pandemic-free world’ and ‘world including a pandemic’ are of interest. […] In any trial, investigators should; (1) Clarify the treatment estimand of interest with respect to the occurrence of the pandemic; (2) Establish what data are missing for the chosen estimand; (3) Perform primary analysis under the most plausible missing data assumptions followed by; (4) Sensitivity analysis under alternative plausible assumptions. […] To obtain an estimate of the treatment effect in a ‘pandemic-free world’, participant data that are clinically affected by the pandemic (directly due to infection or indirectly via treatment disruptions) are not relevant and can be set to missing. […] For the treatment effect in the ‘world including a pandemic’, all participant data is relevant and should be included in the analysis. | 2020-08-14 |
| 32787822 | It is very challenging to treat such cancer patients because of the complexity of providing care and treatment, along with COVID-19. […] Hence, an effective treatment comparison strategy is needed. | 2020-08-14 |
| 32787916 | In the next step, the health education about COVID-19 should be strengthened and carried out according to the special culture of ethnic minorities to enhance public awareness of timely medical treatment. | 2020-08-14 |
| 32787937 | We collected chest CT scans of 202 patients diagnosed with the COVID-19, and try to develop a rapid, accurate and automatic tool for severity screening follow-up therapeutic treatment. | 2020-08-14 |
| 32788008 | All patients had a positive nucleic acid test for 2019 novel coronavirus (2019-nCoV), and were discharged after clinical treatment with oxygen therapy, antiviral, antibacterial, anti-inflammatory, and nutritional support. | 2020-08-14 |
| 32788025 | To make a new simple respirator and observe the oxygen therapy effect of the respirator on patients with severe and critical coronavirus disease 2019 (COVID-19). […] Based on the infectivity and hospital requirements of COVID-19, a new simple respirator was designed by the medical staff of the Department of Anesthesiology of the Second Affiliated Hospital of Nanchang University, which was applied on the 22 patients with severe and critical COVID-19 who needed oxygen therapy admitted to the Cancer Center of Tongji Medical College of Huazhong University of Science and Technology from February 15th to March 15th in 2020. […] The new simple respirator can significantly improve the oxygen therapy effect of patients with severe and critical COVID-19. | 2020-08-14 |
| 32788071 | As we face the threat of emerging and re-emerging infectious diseases, this is a stark reminder to invest in population health, climate change countermeasures, a global health surveillance system and effective research into identifying pathogens, their treatment and prevention and effective health delivery systems. | 2020-08-14 |
| 32788120 | Secondary outcomes include two-week and three-week mortality, the incidence of VTE, acute kidney injury and continuous renal replacement therapy (CRRT). | 2020-08-14 |
| 32788191 | This longitudinal professional survey aims to understand the evolving and cumulative effects of working during the COVID-19 outbreak on the psychological well-being of doctors working in emergency departments (ED), intensive care units (ICU) and anaesthetics during the pandemic. | 2020-08-14 |
| 32788235 | From a total of 14 MSI-H metastatic prostate cancer patients at participating centers, nine patients with mCRPC with 56% bone, 33% nodal, 11% liver and 11% soft-tissue metastases and a median PSA of 29.3 ng/dL, were treated with pembrolizumab after 2 lines of therapy for CRPC. […] Four patients (44%) achieved PSA50 after a median of 4 (3-12) weeks after treatment initiation including three patients with >99% PSA decline. […] At time of cut-off, four patients were still on pembrolizumab while four patients discontinued therapy due to progressive disease and one due to COVID-19 infection. | 2020-08-14 |
| 32788312 | Treatment is primarily supportive, however, prognosis is dismal in those who need invasive ventilation. | 2020-08-14 |
| 32788344 | These information are valuable for the understanding of COVID-19 pathogenesis, identification of biomarkers and development of the optimal anti-inflammation therapy. | 2020-08-14 |
| 32788432 | We describe the presentation, treatment and outcome of children with multisystem inflammatory syndrome with COVID-19 (MIS-C) in Mumbai metropolitan area in India. […] Steroids were used most commonly for treatment (96%), usually along with intravenous immunoglobulin (IVIg) (65%). […] Further studies and longer surveillance of patients with MIS-C are required to improve our diagnostic, treatment and surveillance criteria. | 2020-08-14 |
| 32788506 | Actually, they can reliably indicate the use of antithrombotic therapy at prophylactic or therapeutic doses (mainly D-dimer), as has already been established in those patients who, after an individualized assessment, appear to be at high risk for thrombotic events. | 2020-08-14 |
| 32788835 | Up till now, several attempts have been made for potential therapeutics against SARS-COV2. […] In this retrospective, single-center study, we extracted data from 122 COVID-19, RT-PCR confirmed patients. who were treated with a new treatment strategy of lianhuaqingwen with Arbidol Hydrochloride. | 2020-08-14 |
| 32788840 | During this period, Malaysians displayed a variety of behaviour changes as a response to COVID-19, including panic buying, mass travelling during movement restriction and even absconding from treatment facilities. | 2020-08-14 |
| 32788884 | Our research could assist the clinicians recognize severe and critically ill patients timely and focus on the expectant treatment for each patient. | 2020-08-14 |
| 32788913 | Early diagnosis, treatment and future prevention are keys to COVID-19 management. […] Remdesivir may be the most promising therapy up till now. […] Food and Drug Administration (FDA) has granted emergency use authorization (EUA) for the investigational Remdesivir as a potential antiviral for COVID-19 treatment. […] On May 7, 2020, Gilead Sciences, announced that the Japanese Ministry of Health, Labour and Welfare (MHLW) has granted regulatory approval of Veklury® (Remdesivir) as a treatment for SARS-CoV-2 infection, the virus that causes COVID-19 acute respiratory syndrome, under an exceptional approval pathway. | 2020-08-14 |
| 32789020 | We describe the case of a 64-year-old woman with microbiologically confirmed COVID-19-induced respiratory distress whose treatment resulted in a negative nasopharyngeal swab reverse transcriptase PCR (RT-PCR) result for COVID-19. | 2020-08-14 |
| 32789084 | There were four patients (30.8%) of tuberculosis of the spine of whom two (50%) were managed with posterior decompression, debridement, and stabilization with pedicle screws, samples for culture, biopsy, and cartridge-based nucleic acid amplification test (CBNAAT) were collected during the procedure; for the remaining two patients (50%), a trans-pedicular biopsy was performed to confirm the diagnosis for initiation of anti-tubercular therapy. | 2020-08-14 |
| 32789088 | The heterogeneous nature of the symptoms of the disease caused by SARS-CoV-2, coronavirus disease 2019 (COVID-19), ranging from being asymptomatic to severe acute respiratory distress syndrome (ARDS), has created significant interest in potential therapeutics. […] One medication that emerged as an early frontrunner as a promising therapeutic was hydroxychloroquine (HCQ), a common antimalarial and lupus drug. […] We present the cases of two COVID-19-positive patients treated with HCQ at our institution, which showed adverse effects of the medication. | 2020-08-14 |
| 32789106 | The man had been under treatment for 2 years with Adalimumab, a tumor-necrosis-factor (TNF) inhibitor, for ulcerative colitis. | 2020-08-14 |
| 32789144 | The patient responded well to high-dose LMWH treatment with cessation of the embolic process. | 2020-08-14 |
| 32789145 | Unusual radiological findings are being seen in COVID-19 patients.Pleural effusion in a mildly symptomatic patient is a rare presentation of the disease.Early aggressive treatment can produce dramatic improvement in COVID-19 pneumonia. | 2020-08-14 |
| 32789160 | The patient required continuous positive airway pressure therapy (CPAP) in the hospital ward and subsequently orotracheal intubation while in intensive care unit. […] The patient laid in lateral decubitus position for several hours every day while receiving CPAP therapy. | 2020-08-14 |
| 32789282 | All published COVID-19 treatment-related clinical research studies with study participants in the United States were identified. […] For each study, the date published, treatment investigated, study design, race/ethnicity of participants, sample size and study site were recorded. […] Given that racial/ethnic disparities in COVID-19 disease burden and outcomes have emerged in the United States, it is essential that all investigators uniformly report race/ethnicity data as well as attempt, in earnest, to obtain representativeness among study participants in order to ensure that we do not develop a further widening of the treatment gap during this pandemic. | 2020-08-14 |
| 32789604 | The systematic use of unfractionated heparin therapy to prevent circuit thrombosis is warranted during ECMO support. […] The clinical presentation and management of heparin-induced thrombocytopenia, which is a rare but life-threatening complication of heparin therapy, has not been described in those patients yet. […] We report herein two cases of laboratory-confirmed HIT in COVID-19 patients with severe ARDS admitted to our intensive care unit for VV-ECMO support and the successful use of argatroban as an alternative therapy. | 2020-08-14 |
| 32789663 | In an effort to reduce the severity of organ dysfunction, including respiratory insufficiency, monoclonal antibodies (Mabs) that block the interleukin-6 receptor, such as tocilizumab, sarilumab, and siltuximab, are under investigation for the treatment of COVID-19. […] The short half-life (4-6 h) of the drug offers the opportunity for ideal monitoring of the degree and duration of cytokine blocking, simply by the adjusting dose and duration of therapy. | 2020-08-14 |
| 32789756 | • The computer software has the potential to assist in the detection of the pneumonic regions, monitor disease progression, and assess treatment efficacy related to COVID-19. | 2020-08-14 |
| 32789802 | First, those who survived the first wave developed immunity to the second wave, highlighting the potential of passive immunity-based treatments like convalescent plasma and cell-based therapy. […] This review will cover our current understanding of the pathology and treatment for COVID-19 and highlight similarities between past pandemics. | 2020-08-14 |
| 32789839 | However, no targeted medication or vaccines for COVID-19 are yet available. […] The management of cardiovascular disease in patients with COVID-19 include general supportive treatment, circulatory support, other symptomatic treatment, psychological assistance as well as online consultation. | 2020-08-14 |
| 32790028 | Therefore, in this study, we aimed to evaluate the impact of COVID-19 pandemic on lung cancer treatment scheduling. […] We retrospectively reviewed the medical records of lung cancer patients who were undergoing anticancer treatment at the National Hospital Organization Kyoto Medical Center (600 beds) in Kyoto, Japan, between 1 March 2020 and 31 May 2020. […] After the medical records were reviewed, the patients were assigned to one of two groups, depending on whether their lung cancer treatment schedule was delayed. […] We assessed the characteristics, types of histopathology and treatment, and the reason for the delay. […] A total 15 (9.1%) patients experienced a delay in lung cancer treatment during the COVID-19 pandemic. […] Patients with a treatment delay received significantly more immune checkpoint inhibitor (ICI) monotherapy than patients without a treatment delay (P = 0.0057). […] On the contrary, no patients receiving molecular targeted agents experienced a treatment delay during the COVID-19 pandemic period (P = 0.0027). […] We determined that 9.1% lung cancer patients suffered anxiety and requested a treatment delay during the COVID-19 pandemic. | 2020-08-14 |
| 32790065 | The human viral challenge model studies can shorten the time to assess the efficacy of a new vaccine or treatment by combining this with the assessment of safety. […] In the early 2000s, the authors successfully developed a pathogenic human viral challenge model for another virus for which there was no effective treatment and established it to evaluate potential therapies and vaccines against respiratory syncytial virus. | 2020-08-14 |
| 32790253 | For the prevention and treatment of new coronavirus infection COVID-19, a significant role is played by the correction of eating disorders, including vitamin and micronutrient deficiency. […] Another aspect that the medical community has faced in connection with the pandemic is the need to reorient specialized medical organizations that have not previously worked with patients with infectious diseases in order to create Clinical centers for the treatment of the new coronavirus infection COVID-19. | 2020-08-14 |
| 32790309 | The combination of such powerful tools might help us understand the clotting phenomenon and pave the way for development of new diagnostics and therapeutics in the fight against COVID-19. | 2020-08-14 |
| 32790493 | Standard poststroke treatment monitoring protocols are made problematic during the coronavirus disease 2019 (COVID-19) pandemic by the frequency of patient assessments, requiring repeated donning and doffing procedures in a short interval of time. […] A streamlined poststroke treatment protocol was developed to limit frequency of patient encounters while maximizing the yield of each encounter by grouping together different components of poststroke care into single bedside visits. […] Of these, 33 (47.1%) patients received acute reperfusion therapy. | 2020-08-14 |
| 32790495 | Health professionals must take immediate steps to ensure equitable treatment of SGM populations. | 2020-08-14 |
| 32790652 | Treatment with intravenous immunoglobulin and aspirin was used because this regimen has been shown to be beneficial in vasculitis of Kawasaki disease. | 2020-08-14 |
| 32790662 | Treatment of methanol poisoning includes supportive care, correction of acidosis, administration of an alcohol dehydrogenase inhibitor (e.g., fomepizole), and frequently, hemodialysis. | 2020-08-14 |
| 32790663 | As the COVID-19 pandemic continues to expand in many jurisdictions, clinicians should be aware of the signs and symptoms of MIS-C and report suspected cases to their state or local health departments; analysis of reported cases can enhance understanding of MIS-C and improve characterization of the illness for early detection and treatment. | 2020-08-14 |
| 32790733 | Hydroxychloroquine has been touted as a potential COVID-19 treatment. […] Tocilizumab, an inhibitor of IL-6, has also been proposed as a treatment of critically ill patients. […] In this retrospective observational cohort study drawn from electronic health records we sought to describe the association between mortality and hydroxychloroquine or tocilizumab therapy among hospitalized COVID-19 patients. […] Among 547 evaluable ICU patients, including 134 receiving tocilizumab in the ICU, an exploratory analysis found a trend towards an improved survival association with tocilizumab treatment (adjusted HR, 0.76 [95% CI, 0.57-1.00]), with 30 day unadjusted mortality with and without tocilizumab of 46% versus 56%. | 2020-08-14 |
| 32790773 | In mixed urban/rural geographies steps may need to be taken to temporarily accommodate renal COVID-19 positive patients closer to treatment facilities. | 2020-08-14 |
| 32790836 | The rate of glucocorticoid therapy (36.7% vs 25.5%), Vitamin C (23.3% vs 11.8%), mechanical ventilation (21.9% vs 7.6%), intensive care unit admission (12.6% vs 3.7%) and mortality (16.7% vs 4.7%) were higher in patients with CVD (both p < 0.05). | 2020-08-14 |
| 32790891 | Applications of this tool include early identification for specific treatment and isolation, rational use of laboratory tests, and input for modelling epidemiological trends. | 2020-08-14 |
| 32790918 | These included mechanical ventilation, observed in 280 (29.7%) patients with an ROC yielding an area under the curve (AUC) of 0.769, and new renal replacement therapy, observed in 80 (8.5%) of patients with an ROC yielding an AUC of 0.787. | 2020-08-14 |
| 32791067 | The visual acuity as measured by the GoCheck Kids application was compared with that of the Amblyopia Treatment Study (ATS) and the authors’ clinic protocol. […] GoCheck Kids as checked by a family member provided a modest correlation of visual acuity compared to the chart screen and a fair correlation of visual acuity compared to HOTV-Amblyopia Treatment Study protocol, although most were within 1 line. | 2020-08-14 |
| 32791191 | This case highlights that the shift of coagulation profile toward hypercoagulability was associated with the acute ischemic event and influenced the therapy. | 2020-08-14 |
| 32791222 | As health care workers and society adjust to focus treatment and prevention of COVID-19, other facets of the health care enterprise are affected, particularly surgical volume and revenue. […] We also review strategies for triaging neurosurgical disease as needing emergent, urgent, or routine operative treatment. | 2020-08-14 |
| 32791240 | Development of new interventions including therapeutics and vaccines against SARS-CoV-2 will require time and validation before it could be made available for public use. […] Keeping in view of the emergent and evolving situation the motive is to repurpose and test the immediate efficacy of available drugs and therapeutics against COVID-19. | 2020-08-14 |
| 32791241 | There is currently no treatment known to alter the course of coronavirus disease 2019 (COVID-19). […] A review of articles published in PubMed was performed on 13 July 2020 to summarize the currently available evidence in human studies for convalescent plasma as a treatment for coronaviruses. […] There is currently no effective treatment for COVID-19, and preliminary trials for convalescent plasma suggest that there may be some benefits. | 2020-08-14 |
| 32791493 | Participants who sought health care services were asked additional questions regarding diagnostics and treatment. | 2020-08-14 |
| 32791519 | Following the suspension of elective surgery, priority was placed in providing urgent and emergency surgery for patients with no alternative treatment. | 2020-08-14 |
| 32791552 | As there is no evidence that inhibition of the renin-angiotensin-aldosterone-system is harmful in COVID-19, therapy should be continued as indicated in hypertension or heart failure patients. […] In times of rigorous public health measures such as social distancing, efforts should be undertaken to ensure timely treatment of acute CVD and continuation of guideline-directed treatment in order to avoid an increase in morbidity and mortality. | 2020-08-14 |
| 32791668 | Assessing the effectiveness and safety of acupuncture therapy for treating patients with COVID-19 is the main purpose of this systematic review protocol. | 2020-08-15 |
| 32791675 | Lianhua Qingwen has been used in the treatment of COVID-19 in China, but there is no systematic review about it. […] This study will systematically evaluate its efficacy and safety in the treatment of COVID-19. | 2020-08-15 |
| 32791699 | Some research reports have shown that traditional Chinese medicine has a significant effect on COVID-19 infection, and the treatment of traditional Chinese medicine is used in some special people, such as children. […] This systematic review protocol is designed to provide evidence regarding the effectiveness and safety of traditional Chinese medicine for the treatment of children with COVID-19, such evidence may be useful and important for clinical treatment decisions. | 2020-08-15 |
| 32791723 | Traditional Chinese medicine plays an irreplaceable role in the treatment and prevention of epidemic diseases in China. […] Our findings will evaluate the feasibility of acupuncture and related interventions as adjunctive therapy for anxiety in COVID-19 patients, which will be disseminated in a relevant conference and published in a peer-reviewed publication. | 2020-08-15 |
| 32791731 | The pregnant women received nebulized inhalation and oral cephalosporin treatment in a community hospital and was discharged after the symptoms disappeared. | 2020-08-15 |
| 32791748 | With the emergence 2019 novel coronavirus (SARS-CoV-2), expanded guidelines have not been proposed for screening in these patients before starting advanced therapy. […] We present an unique circumstance whereas a patient with a 5 year history of inflammatory muscle disease, diagnosed by clinical history and muscle biopsy with elevated creatine kinase levels, suffered a hypoxemic cardiopulmonary arrest due to asymptomatic SARS-CoV-2 after receiving advanced immunosuppressive therapy. […] After no improvement with intravenous immunoglobulin the patient received mycophenolate and plasma exchange therapy. […] We conclude that rheumatic patients, asymptomatic for SARS-CoV-2 infection, be screened and tested before initiating second-line immunosuppressive treatment. | 2020-08-15 |
| 32791753 | To provide the latest evidence of clinical efficacy and safety of arbidol in the treatment of COVID-19. | 2020-08-15 |
| 32791754 | We aim to assess the efficacy and safety of Lianhua Qingwen combined with Conventional antiviral Western Medicine in Clinical treatment of COVID-19 or asymptomatic infection. […] STATA15.1 and RevMan5.3 software were used to analyze meta outcomes of different intervention measures for the treatment of new crown pneumonia and the control group (conventional antiviral western medicine treatment) clinical efficacy. […] This study will provide a relatively high-quality synthesis of current evidence of Lianhua Qingwen combined with Conventional antiviral Western Medicine in the treatment of COVID-19 from several aspects including the Clinical effective rate, CT improvement rate, severe conversion rate, antipyretic time, disappearance rate of fever symptoms, disappearance rate of cough symptoms, disappearance rate of asthenia symptoms, and adverse drug events. […] This systemic review will evaluate the efficacy and safety of Lianhua Qingwen combined with Conventional antiviral Western Medicine in the treatment of COVID-19. | 2020-08-15 |
| 32791757 | The aim of this study was to examine the anxiety status of the frontline clinical nurses in the designated hospitals for the treatment of coronavirus disease 2019 (COVID-19) in Wuhan and to analyze the influencing factors, to provide data for psychologic nursing.This study used a cross-sectional survey design and convenience sampling. […] The frontline nurses working in the designated hospitals for the treatment of COVID-19 in Wuhan had serious anxiety. | 2020-08-15 |
| 32791938 | Breast cancer (BC) treatments, including chemotherapy (CT), targeted therapy and immunotherapy can weaken the immune system and possibly cause lung problems. | 2020-08-15 |
| 32791953 | On admission, medical therapy, including angiotensin-converting enzyme inhibitors and angiotensin receptor blockers use, was similar between cohorts. | 2020-08-15 |
| 32792041 | We systematically reviewed the existing clinical evidence of HCQ use for the prevention and treatment of COVID-19. […] A total of 623 studies were screened; 17 studies evaluating HCQ treatment were included. […] There is no evidence supporting HCQ for prophylaxis or treatment of COVID-19. | 2020-08-15 |
| 32792042 | Such care is complicated by the need for complex critical care, dynamic treatment guidelines, and a vague knowledge regarding the disease’s pathophysiology. | 2020-08-15 |
| 32792043 | Despite multiple publications and increasing knowledge regarding the biological secrets of SARS-CoV-2, as of the writing of this paper, there is neither an approved vaccine nor medication to prevent infection or cure for this highly infectious disease. | 2020-08-15 |
| 32792048 | This perspective piece focuses on the main challenges faced by Italian hospital managements: hospital overcrowding; the need for urgent reorganization of the country’s healthcare systems; the lack of data regarding COVID-19 diagnostics, clinical course, and effective treatment; individual and collective consequences of the crisis; and the importance of disease containment measures and early treatment strategies. | 2020-08-15 |
| 32792167 | Information was collected on the use of therapeutic agents for human therapy in patients with COVID-19 up to May 2020. […] Most of the clinical trials are ongoing and hence, there is a lack of precise results for the treatment.There is a lack of high-quality clinical evidence. | 2020-08-15 |
| 32792249 | We encountered 2 cases of COVID-19 with progression resulting in severe respiratory failure and improvement without any specific treatment. | 2020-08-15 |
| 32792254 | There is currently no drug or therapy that cures COVID-19, a highly contagious and life-threatening disease. […] Further, included RCTs had a control group that was given standard care (SC; such as conventional Western medicine treatments or routine medical care), and a treatment group that was given SC plus CHM. […] The primary outcomes included scores that represented changes in symptoms and signs over the course of treatment. […] Current evidence shows that CHM, as an adjunct treatment with standard care, helps to improve treatment outcomes in COVID-19 cases. | 2020-08-15 |
| 32792262 | The 2019 novel coronavirus disease (COVID-19) pandemic poses unique challenges to the medical community as the optimal treatment has not been determined and is often at the discretion of institutional guidelines. | 2020-08-15 |
| 32792417 | Convalescent plasma (CP) therapy has been used since the early 1900s to treat emerging infectious diseases; its efficacy was later associated with the evidence that polyclonal neutralizing antibodies can reduce the duration of viremia. […] Recent large outbreaks of viral diseases for which effective antivirals or vaccines are still lacking has renewed the interest in CP as a life-saving treatment. […] The ongoing COVID-19 pandemic has led to the scaling up of CP therapy to unprecedented levels. | 2020-08-15 |
| 32792455 | The e-mental health intervention ‘CoPE It’ consists of four 30 min modules, conducted every other day, involving psychotherapeutic techniques of mindfulness-based stress reduction and cognitive-behavioural therapy. | 2020-08-15 |
| 32792628 | Therefore, a high-throughput assay to measure SARS-CoV-2 neutralizing antibodies is urgently needed for COVID-19 serodiagnosis, convalescent plasma therapy, and vaccine development. | 2020-08-15 |
| 32792708 | Treatment of chronic pain is an essential service. | 2020-08-15 |
| 32792754 | Reproductive care is essential for the well-being of society and therefore the treatment needs to be completely re-thought and individualised. | 2020-08-15 |
| 32792942 | Remdesivir (RDV, GS-5734), a broad-spectrum antiviral drug in the class of nucleotide analogs, has been particularly tailored for treatment of coronavirus infections. | 2020-08-15 |
| 32793008 | A significantly increased need of therapy adjustment and family accommodation was also observed. | 2020-08-15 |
| 32793181 | As there is no specific treatment prescribed to treat COVID-19, the seeking of suitable therapeutics among existing drugs seems valuable. […] The structure availability of coronavirus macromolecules has encouraged the finding of conceivable anti-SARS-CoV-2 therapeutics through in silico analysis. […] In conclusion, owing to their ability to target functional macromolecules of SARS-CoV-2, along with positive ADMET properties, quinoline,1,2,3,4-tetrahydro-1-[(2-phenylcyclopropyl)sulfonyl]-trans-(8CI), saquinavir, elvitegravir, oxolinic acid, and rilapladib are suggested for the treatment of COVID-19. | 2020-08-15 |
| 32793246 | Since both targeting strategies are different, the window drug administration plays a crucial role in the efficacy of the treatment. | 2020-08-15 |
| 32793443 | Since there is not a medication or vaccine for treating the disease and drug development project is a time and cost consuming process, drug repurposing approaches may yield to proper curing plans. | 2020-08-15 |
| 32793504 | Recent epidemiological models show that, without effective treatment or vaccine, there will be a long-lasting phase of cohabitation with the virus. | 2020-08-15 |
| 32793519 | This study argues the main concepts that need to be considered for the gradual reopening of dental offices include treatment planning approaches, fundamental elements needed to prevent transmission of SARS-CoV-2 virus in dental healthcare settings, personal protection equipment (PPE) for dental health care providers, environmental measures, adjunctive measures, and rapid point of care tests in dental offices. | 2020-08-15 |
| 32793619 | Therefore, the impact of pre-existing liver disease on treatment and clinical outcomes of COVID-19 should be determined. | 2020-08-15 |
| 32793661 | Disease treatment, spike protein and vaccine may be hotspots in the future. | 2020-08-15 |
| 32793725 | With no current vaccine, treatment is still a critical intervention for minimizing morbidity and preventing disease-specific mortality. […] This study aimed to assess the clinical outcomes of critically ill COVID-19 patients using Tocilizumab treatment to provide recommendations for the treatment of COVID-19 patients with severe disease. […] Four to eight milligrams (mg)/kilogram (kg) of Tocilizumab was prescribed, with Chinese treatment guidelines. […] Anti-inflammatory treatment with Tocilizumab was found to improve inflammatory responses in critically ill COVID-19 patients. […] Although some side reactions will occur, patients can gradually recover without affecting the efficacy of the therapy. | 2020-08-15 |
| 32793973 | If a patient was diagnosed with COVID-19, immunomodulatory therapy was mostly held. | 2020-08-15 |
| 32793988 | Elective units in particular showed a shortfall up to 128,163 € with respect to inpatient treatment for 7 weeks. | 2020-08-15 |
| 32794113 | Data extraction included diagnosis, demographics, immunosuppressive treatment, comorbidities, and laboratory tests. […] There were no statistically significant between-group differences for rheumatologic diagnosis and for baseline use of immunosuppressive therapy except for glucocorticoids that were more frequent in hospitalized patients. | 2020-08-15 |
| 32794144 | Management of stroke patients in the acute setting is a high-stakes task with several challenges including the need for rapid assessment and treatment, maintenance of high-performing team dynamics, management of cognitive load affecting providers, and factors impacting team communication. | 2020-08-15 |
| 32794245 | She was treated with antiviral agents and steroid pulse therapy. […] Thus, early treatment is essential to prevent viral replication from reaching a level that triggers DAD. | 2020-08-15 |
| 32794348 | This data supports the notion of IL-1β blockade in treatment of COVID-19. | 2020-08-15 |
| 32794435 | Patients hospitalised with COVID-19 have increased morbidity and mortality, which requires extensive involvement of specialist Hospital Palliative Care Teams. […] Evaluating the response to the surge in demand for effective symptom management can enhance provision of Palliative Care in this patient population. […] To characterise the symptom profile, symptom management requirements and outcomes of hospitalised COVID-19 positive patients referred for Palliative Care, and to contextualise Palliative Care demands from COVID-19 against a ‘typical’ caseload from 2019. […] Demographic data, patient symptoms, drugs/doses for symptom control, and patient outcomes were captured for all COVID-19 positive patients referred to Hospital Palliative Care Teams between 30th March and 26th April 2020. […] Hospitalised COVID-19 positive patients referred for Palliative Care may have a short prognosis, differ from ‘typical’ caseload, and predominantly suffer from dyspnoea and agitation. | 2020-08-15 |
| 32794460 | During pandemic COVID-19 was the main concern in every clinic and as we discuss here overlapping respiratory diseases may result in delaying of the diagnosis and treatment. | 2020-08-15 |
| 32794463 | In the case of convalescent plasma, this therapy consists in obtaining neutralizing antibodies from previously infected individuals by plasmapheresis and administering them to patients with severe disease. […] Recently, the use of convalescent plasma has shown promising results in preliminary studies, with case series reporting a decrease in temperature, and viral load, as well as improvement in clinical parameters among patients receiving this treatment. […] However, there are still unmet needs regarding the safety profile, tolerability, dosage, and timing this therapy should be given. […] Based on this, the objective of our study was to develop and propose a practical approach for the compassionate use of convalescent plasma for the treatment of patients with severe COVID-19, given the constrains and limitations of developing countries. | 2020-08-15 |
| 32794466 | We collected patient’s demography, symptoms, comorbidities, therapy, laboratory, chest x-ray and ECG consecutively. | 2020-08-15 |
| 32794674 | On the basis of the latest literature and evidence-based medical evidence on the fight against COVID-19 epidemic and steroid ONFH diagnosis and treatment, the Bone Circulation and Osteonecrosis Professional Committee, Shockwave Medical Specialty Committee of Chinese Research Hospital Association organized Chinese bone necrosis related experts to jointly write this consensus, focusing on the prevention strategy and the protective management measures in the ONFH diagnosis and treatment process during the prevention and control of COVID-19, which can provide reference for hospitals at all levels to carry out early prevention and treatment of ONFH. | 2020-08-15 |
| 32794675 | This article, based on Prevention and Treatment of Pressure Ulcers/Injuries: Quick Reference Guide 2019, references, and clinical experiences of wound specialists in West China Hospital of Sichuan University, summarize the preventive and protective measures of West China Hospital for medical personnel to prevent DRPI, so as to provide clinical preventive measurements for medical personnel. | 2020-08-15 |
| 32794676 | The patient had a 10-year history of chronic nephritis and began dialysis treatment due to renal failure 1 month ago. […] Then, the patient was transferred to the isolation ward, where he was given anti-infection, anti-virus, expectorant, heat-clearing and detoxifying drugs, bedside dialysis, and nutrition support symptomatic treatment. […] After 2 weeks of treatment, the patient is getting better, with no fever, cough, wheezing, and other discomfort. | 2020-08-15 |
| 32795131 | Previously, discharged patients with coronavirus disease 2019 (COVID-19) patients met the criteria of China’s pneumonia diagnosis and treatment program of novel coronavirus infection (trial version 7) for cure of viral infection. | 2020-08-16 |
| 32795165 | Despite the danger of infection during the outbreak of the 2019 novel coronavirus (COVID-19) in Wuhan, many patients still need surgical treatment. | 2020-08-16 |
| 32795186 | A better understanding of COVID-19 pathophysiology, in particular hemostatic disorders, will help to choose appropriate treatment strategies. | 2020-08-16 |
| 32795196 | As a result of their immunocompromised status associated with disease and treatment, patients with cancer face a profound threat for higher rates of complications and mortality if they contract the coronavirus disease 2019 infection. […] Medical oncology communities have developed treatment modifications to balance the risk of contracting the virus with the benefit of improving cancer-related outcomes. […] We studied a cohort of 282 patients receiving treatment and found that 159 patients (56.4%) had treatment modifications. […] The incidence of treatment modification was observed in patients undergoing adjuvant and neoadjuvant (41.4%), palliative (62.9%), or injectable endocrine or bone-modulating only (76.0%) treatments. […] Treatment modifications in 112 patients (70.4%) were recommended by providers, and 47 (29.6%) were initiated by patients. […] The most common strategy of modification was to skip or postpone a scheduled treatment (49%). […] Among treatment with no modifications, treatment regimens were maintained in patients who tolerated treatment well (37.0%), in treatments with curative intent (22%), and in symptomatic patients who required treatment (14%). […] Our observation and analysis suggested that the primary goal of treatment modification was to decrease potential exposure. […] Providers have to consider individualized recommendations incorporating multiple factors, such as tolerance, potential toxicity, treatment nature and route, and disease severity. | 2020-08-16 |
| 32795225 | Recent cytotoxic chemotherapy treatment was not associated with adverse COVID-19 outcomes. […] Interactions among antineoplastic therapy, cancer type, and COVID-19 are complex and warrant further investigation. | 2020-08-16 |
| 32795227 | A total of 270 of 1,016 (26.6%) of the patients were undergoing active anticancer treatment in a neoadjuvant/adjuvant and 560 of 1,016 (55.1%) in a palliative setting. […] Our data indicate that continuation of active anticancer therapy and follow-up visits in a large tertiary care hospital are feasible and safe after implementation of strict population-wide and institutional safety measures during the current COVID-19 pandemic. | 2020-08-16 |
| 32795303 | The attention of health systems is mainly focused on COronaVIrus Disease 19 patients and on the risk that intensive care units might be overwhelmed by the serious pulmonary complications. […] When dealing with COronaVIrus Disease 19, policy makers and healthcare personnel should consider the indirect effects on the treatment of non-communicable diseases. | 2020-08-16 |
| 32795359 | Mesenchymal stem cell-derived exosomes (MSC-Exo) are believed to have anti-inflammatory effects and immune-modulating capacity as well as the ability to induce tissue regeneration, suggesting a significant therapeutic opportunity that could be used to SARS-CoV-2 pneumonia treatment. […] MSC-Exo may serve as a promising tool in the treatment of SARS-CoV-2 pneumonia. […] However, further work needs to be carried out to confirm the efficacy of exosomes in the treatment of SARS-CoV-2 pneumonia. | 2020-08-16 |
| 32795424 | Transfusion of convalescent plasma collected from donors who have recovered from COVID-19 is among many approaches being studied as potentially efficacious therapy. […] We are conducting a prospective, propensity score-matched study assessing the efficacy of COVID-19 convalescent plasma transfusion versus standard of care as treatment for severe and/or critical COVID-19. […] These data suggest that treatment of COVID-19 with high anti-receptor binding domain IgG titer convalescent plasma is efficacious in early-disease patients. | 2020-08-16 |
| 32795645 | Although in theory, cloth masks can be helpful to limit the spread of the COVID-19, serious consideration should be given to the choice of textile, the number of layers of cloth used, pre-treatment of the material with water repellent material and other compounds that can enhance the filtration efficiency of the masks without compromising their breathability. | 2020-08-16 |
| 32795828 | Adverse pregnancy outcomes were associated with infection acquired at early gestational ages, more symptomatic presentation, myalgia symptom at presentation, and use of oxygen support therapy. | 2020-08-16 |
| 32795832 | Figuring out the early event of immune dysregulation would provide a potential treatment for COVID-19. […] We hypothesize that MitoQ could act as a potential treatment in COVID-19. […] In this article, we provide evidence to support the use of MitoQ as a potential treatment or adjunct therapy in the context of COVID-19. | 2020-08-16 |
| 32795835 | Teprotumumab is a monoclonal antibody directed against the IGF-1R that was FDA-approved in 2020 for the treatment of Graves’ orbitopathy. […] Once these are ascertained, and if the data support IGF-1 involvement, a randomized, placebo-controlled phase 2A trial of teprotumumab therapy in the setting of COVID-19-related ARDS and non-COVID-19-related ARDS designed to generate initial data on short-term efficacy, safety, dosing and administration should be performed. | 2020-08-16 |
| 32795841 | This study aims to investigate mortality and renal recovery in patients with Acute Kidney Injury (AKI) and Renal Replacement Therapy (RRT) due to COVID-19. | 2020-08-16 |
| 32795893 | No proven effective therapies currently exist for this virus, and efforts to develop antiviral strategies for the treatment of COVID-19 are underway. […] In this review, we describe the latest information in the context of immunological approaches and emerging current antiviral strategies for COVID-19 treatment. | 2020-08-16 |
| 32795897 | This multicenter retrospective cohort study was performed in 8 government-designated treatment centers for COVID-19 patients in China from Dec. 2019 to Mar. […] In the subgroup analysis, it was found that thymosin α1 therapy significantly reduced 28-day mortality (Hazards Ratios HR, 0.11, 95% confidence interval CI 0.02-0.63, P=0.013) via improvement of Pa02/FiO2 (P = 0.036) and prolonged the hospital length of stay (P = 0.024) as well as the total duration of the disease (P=0.001) in the critical type patients, especially those aged over 64 years, with white blood cell >6.8×109/L, neutrophil >5.3×109/L, lymphocyte < 0.73 × 109/L, PaO2/FiO2 < 196, SOFA > 3, and acute physiology and chronic health evaluation (APACHE) II > 7. […] These results suggest that treatment with thymosin α1 can markedly decrease 28-day mortality and attenuate acute lung injury in critical type COVID-19 patients. | 2020-08-16 |
| 32795898 | This study evaluated the potential efficacy of a novel approach to treat COVID-19 patients, using an oxygen-ozone (O2-O3) mixture, via a process called Oxygen-Ozone- Immunoceutical Therapy. […] The methodology met the criteria of a novel, promising approach to treat successfully elderly COVID-19 patients, particularly when hospitalized in intensive care units (ICUs) Experimental design: We investigated the therapeutic effect of 4 cycles of O2-O3 in 50 hospitalized COVID-19 subjects suffering from acute respiratory disease syndrome (ARDS), aged more than 60 years, all males and undergoing non invasive mechanical ventilation in ICUs. […] Following O2-O3 treatment a significant improvement in inflammation and oxygenation indexes occurred rapidly and within the first 9 days after the treatment, despite the expected 14-20 days. […] Our results show that O2-O3 treatment would be a promising therapy for COVID-19 patients. […] This study may encourage the scientific community to further investigate and evaluate the proposed method for the treatment of COVID-19 patients. | 2020-08-16 |
| 32795902 | In this narrative review, based on a selective literature search in EMBASE, MEDLINE, Scopus, The Cochrane Library, Web of Science, and Google Scholar and ClinicalTrials.gov, we have examined the emerging evidence on the possible treatment of CARDS. […] There is still no recommendation for the therapeutic use of any specific agent to treat CARDS because no drugs are validated to have significant efficacy in clinical treatment of COVID-19 patients in large-scale trials. […] The real challenge now is to link the right patient to the right treatment. | 2020-08-16 |
| 32795985 | Dental visits are unpleasant; sometimes, patients only seek treatment when they are in intolerable pain. | 2020-08-16 |
| 32795997 | The COVID-19 pandemic has necessitated a rapid increase of space in highly infectious disease intensive care units (ICUs). […] Virtual family visitation via the Consultant Bridge application, palliative care delivery, and specialist consultation for patients with COVID-19 exemplify the successful adaptation of the vICU implementation. […] Overall responses from patients, families, and physicians are in favor of continued vICU care; however, further research is required to examine the impact of innovative applications of telecritical care in the treatment of critically ill patients. | 2020-08-16 |
| 32796045 | We assessed the association between the outcome and the potential prognostic variables, adjusted by COVID-19 treatment, using logistic regression. | 2020-08-16 |
| 32796159 | In order for public health, care delivery systems, clinicians and other stakeholders to be better prepared for the next wave of SARS-CoV-2 infections, which, at this point, seems inevitable, we need to better understand this disease-not only from a clinical diagnosis and treatment perspective-but also from a forecasting, planning, and advanced preparedness point of view. […] To predict the onset and outcomes of a next wave, we first need to understand the pathologic mechanisms and features of COViD-19 from the point of view of the intricacies of clinical presentation, to the nuances of response to therapy. | 2020-08-16 |
| 32796176 | Transfusion requirements between patients who underwent endoscopic therapy and those who were conservatively managed were not significantly different. | 2020-08-16 |
| 32796217 | Mean C-reactive protein, ferritin, erythrocyte sedimentation rate and lactate dehydrogenase levels after COVID-19 diagnosis were not statistically different and mortality was not different for PLH with a history of antiretroviral treatment. | 2020-08-16 |
| 32796445 | To describe our managing strategy for COVID-19 emergency, to evaluate the adherence to intravitreal treatment (AtT) rate during the outbreak in a referral hospital in Milan and to correlate it with patients clinical features. […] Patients adherent to treatment were significantly younger (p<0.001) and had a lower best-corrected visual acuity in the fellow eye (p=0.046). | 2020-08-16 |
| 32796683 | The development of biological disease-modifying antirheumatic drugs (bDMARDs) and target synthetic DMARDs (tsDMARDs), also known as small molecule inhibitors, represent a breakthrough in rheumatoid arthritis (RA) treatment. […] This review highlights current challenges associated with the treatment of RA using small molecule inhibitors targeting intracellular JAKs/MAPKs/NF-κB/SYK-BTK signaling pathways. […] Indeed, we have provided the latest update on development of small molecule inhibitors, their clinical efficacy and safety as a strategy for RA treatment. […] Interestingly, recent events of SARS-CoV-2 outbreak have demonstrated the potential use of small molecule inhibitors not only in RA treatment, but also in fighting COVID-19 via blocking the viral entry, preventing of hyperimmune activation and reducing cytokine storm. | 2020-08-16 |
| 32796765 | Within a “treatment on a named-patient basis” approach, Adrecizumab was administered to eight extreme-critically ill COVID-19 patients with acute respiratory distress syndrome (ARDS). […] Moreover, six of the patients suffered from acute renal failure, of whom five needed renal replacement therapy. | 2020-08-16 |
| 32796809 | Short-term corticosteroid therapy was initiated, and SpO₂ and radiographic findings promptly improved without use of antiviral agents. | 2020-08-16 |
| 32797188 | This poses a challenge in which clinicians must weigh the benefits of initiation or resumption of antineoplastic therapy against the risks that antineoplastic treatment may worsen outcomes related to COVID-19 infection. […] A recent study of 423 patients at our institution found that patients in active cancer treatment who develop COVID-19 infection did not fare any worse than other hospitalized patients yet guidance as to who requires testing prior to antineoplastic therapy and when to resume therapy post-COVID diagnosis remains unknown. […] The taskforce focused on the ambulatory care testing guidelines only, as all inpatients receiving antineoplastic therapy are tested for COVID-19 prior to hospital admission. […] The guidelines focus solely on the safety and well-being of the individual patient undergoing antineoplastic therapy and are not designed to address infection control issues. | 2020-08-16 |
| 32797326 | Despite growing knowledge of the nature of Severe Acute Respiratory Syndrome coronavirus-2 (SARS-CoV-2), treatment options are still poorly defined. | 2020-08-16 |
| 32797464 | This document summarizes the experience of the International Uveitis Study Group (IUSG), the Intraocular Inflammation Society (IOIS) and the Foster Ocular Inflammation Society (FOIS) and can aid as a guide for the treatment of uveitis patients in the era of COVID-19 pandemic. | 2020-08-16 |
| 32797762 | Numerous clinical trials are being initiated to identify effective treatments for COVID-19 and are directed toward treatment of the two phases of infection and inflammation that influence the pathogenesis of COVID-19. […] An important resource for the allergist/immunologist is the COVID-19 Treatment Guidelines Panel (COVID-19 TGP), a National Institutes of Health sponsored panel of U.S. physicians, statisticians, and other experts, which has developed a set of continuously updated treatment guidelines intended for clinicians caring for patients during the rapidly evolving COVID-19 pandemic. […] In this report, the pathogenesis of COVID-19 and the influence it has on COVID-19 presentations is reviewed, together with recommended potential therapeutic targets and treatment recommendations. | 2020-08-17 |
| 32798019 | The present review found that traditional Chinese herbs commonly used for the clinical treatment of organ damages caused by COVID-19, such as Scutellaria baicalensis, Salvia miltiorrhizaSalvia miltiorrhiza, and ginseng, could act on multiple signaling pathways involved in inflammation, oxidative stress and apoptosis. […] This review provides evidence and support for clinical treatment and novel drug research using TCM. | 2020-08-17 |
| 32798063 | Numerous publications during the COVID-19 pandemic recommended the use of hypofractionated radiation therapy. […] A large number of publications recommended hypofractionated radiation therapy schedules across numerous major disease sites during the COVID-19 pandemic, which were supported by a lower quality of evidence than the highest-quality routinely used dose fractionation schedules. […] These data could also be used to support radiation therapy practices in the event of second waves or surges of the pandemic in new regions of the world. | 2020-08-17 |
| 32798098 | Mental health treatment was modified to limit staff exposure. | 2020-08-17 |
| 32798104 | From 151 consultations, 149 (98.7%) successfully established a working diagnosis and treatment plan and/or concluded an episode of patient care, without the need to convert to a face-to-face encounter between clinician and patient. | 2020-08-17 |
| 32798300 | The results of this study may guide the diagnosis and treatment of coronavirus disease, COVID-19, as well as similar processes that occur with acute respiratory distress syndrome. | 2020-08-17 |
| 32798320 | Nine essential stakeholder engagement practices were reviewed: formative research; stakeholder engagement plan; communications and issues management plan; protocol development; informed consent process; standard of prevention for vaccine research and standard of care for treatment research; policies on trial-related physical, psychological, financial, and/or social harms; trial accrual, follow-up, exit trial closure and results dissemination; and post-trial access to trial products or procedures. | 2020-08-17 |
| 32798346 | Heparin treatment including unfractionated and low molecular weight heparin appears to be associated with better prognosis in severe COVID-19 patients with coagulopathy. | 2020-08-17 |
| 32798373 | To identify potential drugs that can be repurposed for treatment of COVID-19 by using molecular docking based virtual screening of all approved drugs. […] Saquinavir and Beclabuvir were identified as the best novel candidates for COVID-19 therapy by using Virtual Screening of drugs approved for other clinical indications. […] Protease inhibitors approved for treatment of other viral diseases have the potential to be repurposed for treatment of COVID-19. | 2020-08-18 |
| 32798468 | This retrospective cohort study was done in the Paris-Sorbonne University Hospital Network, comprising five intensive care units (ICUs) and included patients who received ECMO for COVID-19 associated ARDS. | 2020-08-18 |
| 32798473 | The high mortality among patients with haematological malignancies hospitalised with COVID-19 highlights the need for aggressive infection prevention strategies, at least until effective vaccination or treatment strategies are available. | 2020-08-18 |
| 32798660 | No therapy has proven to be effective yet to reduce mortality and/or invasive mechanical ventilation (IMV) requirement in COVID-19. […] Tocilizumab (TCZ) in patients with severe COVID-19 could be an effective treatment. […] TCZ was used in patients in critical condition (oxygen therapy flow at TCZ onset was 10.5 L/min and 14/30 patients had ≥ 50% lung involvement on CT scan) as a rescue treatment (8/30 patients who died were not admitted in USC in regard to their comorbidities). | 2020-08-18 |
| 32798764 | Placental extract treatment is proposed as a suitable therapeutic approach consideringthe above properties which could protect against initial viral entry and acute inflammation of alveolar epithelial cells, reconstitute pulmonary microenvironment and regenerate the lung. […] We reviewed useful therapeutic information of placental biomolecules in relation to COVID-19 treatment. […] Executing a clinical trial using placental extract as preventive, protective and/or therapeutic approach for COVID-19treatment could advance the development of a most promising therapeutic candidate that can join the armamentaria against the COVID-19 virus. | 2020-08-18 |
| 32798769 | Current SARS-CoV-2 outbreak have fueled ongoing efforts to exploit various viral target proteins for therapy, but strategies aimed at blocking the viral proteins as in drug and vaccine development have largely failed. […] This demands the understanding of phenotypic and genotypic classification, and pathogenesis of SARS-CoV-2 for the production of potential therapy. […] We also consider the host immune response and viral evasion based on available clinical evidences which would be helpful to remodel COVID-19 pathogenesis; and hence, development of therapeutics against broad spectrum of coronaviruses. | 2020-08-18 |
| 32798855 | Apnea testing was performed for 1 patient due to the decision to withdraw treatment (n = 2), concern for inability to tolerate testing (n = 2) and observation of spontaneous respirations (n = 1). | 2020-08-18 |
| 32799178 | Further studies are needed to determine which parameters are useful in monitoring coagulopathy and which dose of anti-thrombotic therapy in Covid-19 patients is adequate, even when overt DIC is not present. | 2020-08-18 |
| 32799197 | With an expedited and adequate delivery protocol, less invasive treatment principle, and active infection precautious, we found a limited impact of COVID-19 mothers on preterm delivery and neonatal short-term outcomes. | 2020-08-18 |
| 32799213 | Treatment was ineffective, and the patient died. | 2020-08-18 |
| 32799217 | Trimethoprim/sulfamethoxazole combination (TMP/SMX) is considered the treatment of choice but can itself lead to AKI, posing a significant challenge in the management of patients with concomitant COVID-19 and S. maltophilia pneumonia. | 2020-08-18 |
| 32799308 | Healthcare authorities and hospitals must ensure low barriers to treatment and business as usual for all patients. | 2020-08-18 |
| 32799416 | Because I experienced firsthand horrors of expensive vaccines or medicines, I devoted most of my career to develop affordable therapeutics. | 2020-08-18 |
| 32799423 | ACE2 was increased with only a few of the tested medication groups, namely the renin-angiotensin inhibitors, such as enalapril, antibacterial agents, such as nitrofurantoin, and the proton pump inhibitor, omeprazole. | 2020-08-18 |
| 32799566 | The high fatality rate associated with coronavirus infection underlines the urgent need for an effective treatment to reduce disease severity and mortality. […] Nucleoside analogs and IL-6 receptor antagonists have been identified as the best candidates for treatment of this disease. […] Multi-drug therapy by targeting different pathways will need to be corroborated and then confirmed through clinical trials. | 2020-08-18 |
| 32799618 | The specificity of IgM and IgG strips in healthy people and in patients with non-COVID-19 disease was 94%, 96.72% and 95.50%, 99.49%, respectively; and sensitivity of IgM and IgG strips for patients during treatment and follow-up was 63.02%, 37.61% and 87.28%, 90.17%, respectively. | 2020-08-18 |
| 32799694 | We reviewed the application of rehabilitation therapy in the clinical treatment of COVID-19 patients. | 2020-08-18 |
| 32799739 | The importance of caring for children with complex and serious conditions means that paediatric palliative care must continue during pandemics. […] This study, a sub-study of a larger project, aimed to examine real-world instances of communication in paediatric palliative care consultations prior to and during the COVID-19 pandemic to understand how clinicians and families talk about the pandemic. […] Paediatric palliative care consultations prior to, during, and immediately following the initial peak of COVID-19 cases in Australia were video recorded and analysed using Conversation Analysis methods. […] Twenty-five paediatric palliative care consultations (including face-to-face outpatient, telehealth outpatient and inpatient consultations) were video recorded within a public children’s hospital in Australia. […] Topics typical of a standard paediatric palliative care consultation often led to discussion of the pandemic. […] Clinicians should not be surprised by the pervasiveness of COVID-19 or other pandemic talk within standard paediatric palliative care consultations. | 2020-08-18 |
| 32799796 | We presented a 69-year-old Chinese female colon cancer patient with COVID-19, the first case accepted the surgical treatment during the pandemic in China. […] It is meaningful and imperative to share our experience of protecting health care personnels from SARS-CoV-2 infection and providing references for optimizing treatment of cancer patients, at least for the operative intervention with absolute necessity or surgical emergency, during the outbreak of COVID-19. | 2020-08-18 |
| 32799933 | We postulated that adjunctive treatment of established ARDS caused by COVID-19 with intravenous dexamethasone might change the pulmonary and systemic inflammatory response and thereby reduce morbidity, leading to a decrease in duration of mechanical ventilation and in mortality. | 2020-08-18 |
| 32800044 | Continuous positive airway pressure (CPAP) has been suggested as a beneficial treatment for patients with coronavirus disease 2019 (COVID-19). […] The objective of CPAP treatment is to improve oxygenation, unload respiratory muscles and possibly delay or avoid intubation. […] This review describes the physiological rationale behind CPAP therapy for patients with COVID-19 and the clinical experience with CPAP, implemented in a medical ward without prior knowledge of the treatment. […] CPAP has the potential for reducing the burden on intensive care units if implemented on a medical ward by a multidisciplinary approach. | 2020-08-18 |
| 32800066 | Clinical data, treatment and outcome were analysed in this retrospective study of 101 consecutive patients with COVID-19 admitted to a regional Danish hospital from 2 March 2020, based on data from electronic medical records. | 2020-08-18 |
| 32800073 | Twelve (10.4%) received invasive mechanical ventilation and three (2.6%) renal replacement therapy. | 2020-08-18 |
| 32800295 | Thirty-one (31%) patients developed AKI and 1 (1%) patient required renal replacement therapy. | 2020-08-18 |
| 32800347 | The risk of neuropsychiatric side effects of chloroquine and hydroxychloroquine when used for coronavirus disease-2019 treatment is not known. | 2020-08-18 |
| 32800516 | We present a case of a solid organ transplant recipient on immunosuppressive therapy who successfully recovered from COVID-19 infection. […] We also review 10 similar cases found in the literature and describe the clinical course and management, including immunosuppressive therapy. | 2020-08-18 |
| 32800699 | Chinese herbal medicine (CHM) is thought to be a potential intervention in the treatment of coronavirus disease (COVID-19). […] This study aimed to investigate the efficacy and safety of CHM or CHM combination therapy for COVID-19. […] Randomized controlled trials, cohort studies, and case-control studies on CHM or CHM combination therapy for COVID-19 were included. […] Meta-analysis showed that the overall clinical effectiveness (OR = 2.67, 95% CI 1.83-3.89, I2 = 0%), improvement in the CT scan (OR = 2.43, 95% CI 1.80-3.29, I2 = 0%), percentage of cases turning to severe/critical (OR = 0.40, 95% CI 0.24-0.67, I2 = 17.1%), reverse transcription-polymerase chain reaction (RT-PCR) negativity rate (OR = 2.55, 95% CI 1.06-6.17, I2 = 56.4%) and disappearance rate of symptoms (fever, cough, and fatigue) were superior by combined CHM treatment of COVID-19. […] The combined treatment of COVID-19 with Chinese and Western medicine may be effective in controlling symptoms and reducing the rate of disease progression due to low quality evidence. | 2020-08-18 |
| 32800805 | The current COVID-19 pandemic has urged the scientific community internationally to find answers in terms of therapeutics and vaccines to control SARS-CoV-2. | 2020-08-18 |
| 32800857 | We formulated a cost appraisal framework which evaluated the treatment costs averted from the prevention of secondary transmission in the hospital setting, as determined by a branching process infection model, and compared these to the costs of the additional testing required to meet the criteria. | 2020-08-18 |
| 32801052 | Current treatment of patients with coronavirus 2019 (COVID-19) involves repurposed drugs that inhibit viral infection by either binding to their respective targets or via modulating cellular signal transduction. […] However, there is still a great deal of efficacy enhancement through combination therapy and derivatization. […] Combination therapy should involve agents with significant activity and different mechanisms of action. | 2020-08-18 |
| 32801068 | Two hundred thirty-nine patients with epilepsy (53% female, 35% seizure-free, 97% on antiseizure medication) answered a structured audit on telemedical counseling as part of individual outpatients’ care. | 2020-08-18 |
| 32801210 | Secondary outcome measures included changes in surgical extent, numbers referred to MDT, number of patients denied surgery not receiving any treatment and reasons for any variation across the UK. 18 units (75%) provided information from 80 MDT meetings that discussed 1221 patients. […] 10.7% of patients had their management changed-the majority (68%) did not undergo surgery and more than half of this group not undergoing surgery had no active treatment. […] COVID-19 has had an impact on patients requiring surgery for malignant brain tumours, with patients receiving different treatments-most commonly not receiving surgery or any treatment at all. | 2020-08-18 |
| 32801413 | A consensus on what constitutes special treatment for COVID-19 has yet to emerge. | 2020-08-18 |
| 32801428 | The death toll is high, despite the therapy being applied. […] We do not currently have a specific and effective therapy against COVID-19. […] In addition, we do not have a single clinical study that would support prophylactic therapy that could affect COVID-19. | 2020-08-18 |
| 32801547 | Head and neck cancer has a survival rate of 40% to 50% after definitive therapy and the delay in treatment for even 1-2 months may lead to inoperability and poorer outcomes. | 2020-08-18 |
| 32801640 | The antiviral treatment acts as one of the most important means of SARS-CoV-2 infection. […] Alteration of physiological characteristics in special populations may lead to the change in drug pharmacokinetics, which may result in treatment failure or increased adverse drug reactions. […] Here, we reviewed the literature on clinical effects in COVID-19 patients of these antiviral agents and provided the potential antiviral agent options for pregnant women, elderly patients, liver or renal dysfunction patients, and severe or critically ill patients receiving renal replacement therapy or ECMO after SARS-CoV-2 infection. | 2020-08-18 |
| 32801722 | There is an absence of consensus on guidelines or treatment strategies for complex disorders such as multiple sclerosis (MS), in which the risk of infections is higher than in the general population. | 2020-08-18 |
| 32801727 | Immune-based therapies such as chimeric antigen receptor (CAR)-T-cell therapy have revolutionized the landscape of cancer treatment in recent years. […] Although this class of therapy has demonstrated impressive clinical efficacy against cancers that were once thought to be incurable, its success is in part limited by unique toxicities which can be severe or even fatal. […] As a direct anti-cytokine drug, tocilizumab has been a cornerstone in the treatment of CAR-T-associated CRS through its ability to dampen CRS without compromising CAR-T-cell function. […] We also discuss alternative therapies that may be considered for refractory CRS therapy and the use of tocilizumab in the current COVID-19 global pandemic. | 2020-08-18 |
| 32801787 | Treatment strategies incorporating the blockade of migration and differentiation of monocyte-macrophage, such as granulocyte macrophage-colony stimulating factor inhibitors, might enhance the promising results seen so far with selective cytokine blockade. | 2020-08-18 |
| 32801803 | Information recorded included demographic data, medical history, exposure history, underlying comorbidities, symptoms, signs, laboratory findings and radiologic assessments, severity of disease, treatment, and mortality. […] Since a high rate of false negative RT-PCR test was observed, early detection of children with COVID-19 infection by CT is conducive to reasonable management and early treatment. | 2020-08-18 |
| 32801840 | In this review, we will discuss the most recent evidence about the current potential treatment options including anti-inflammatory drugs, angiotensin-converting enzyme inhibitors/angiotensin receptor blockers, nucleoside analogs, protease inhibitors, monoclonal antibodies, and convalescent plasma therapy. […] Moreover, the potential use of convalescent plasma for treatment of COVID-19 infection was described. | 2020-08-18 |
| 32801842 | Otolaryngologic treatment mainly involves supportive adjuvant usage of interferon or antiviral drugs; however, approximately one-third of patients may not survive, and, therefore, otolaryngologists should be familiar with and remain mindful of the disease. | 2020-08-18 |
| 32801857 | This article will discuss the arrangements and management of surgical treatment for patients with breast cancer. | 2020-08-18 |
| 32801886 | Treatment of gastric cancer (GC) patients in the pandemic era with high hospital burden and under severe oncological/surgical resource constraints should implicate a need for resource re-allocation with a new “pandemic” GC treatment algorithm. […] The neoadjuvant/perioperative (radio-)chemotherapy is applied in the majority of advanced GC cases with poor postoperative therapy compliance. […] The pandemic framework to provide optimal care for GC patients must be based on multidisciplinary decision-making and include all anti-cancer treatment options: surgery, systemic therapy, and radiotherapy. | 2020-08-18 |
| 32801972 | The treatment of some acute and worsened cardiovascular diseases has become more complex because of epidemic prevention measures. […] We examined cardiovascular patients in the emergency department, as well as outpatient clinics and inpatient units in the Zhongnan Hospital of Wuhan University, from March 20th to April 17th, 2020, as the study subjects, and we performed standard medical activities according to the principles of border treatment and border protection. […] Additionally, we aimed to minimize the adverse effects of the epidemic on the therapy that was administered to cardiology patients. […] Our study aimed to provide prevention and treatment strategies for the rapid and effective medical recovery of patients in non-COVID-19 designated hospitals in high-risk areas after remission, as well as in low- and medium-risk areas. | 2020-08-18 |
| 32802003 | Results showed that .edu and .org website category sites were excellent in communicating coronavirus related health information; however, they received lower scores for treatment effect and treatment choices. | 2020-08-18 |
| 32802216 | A positive role was seen in pharmacists acting as first-line healthcare providers, creating public’s awareness regarding COVID-19, and being responsible for chronic medication refill during the pandemic. | 2020-08-18 |
| 32802219 | We retrospectively analyzed the clinical data of COVID-19 patients who were cured and discharged from the Public Health Treatment Center of Changsha from January 30, 2020, to February 19, 2020. | 2020-08-18 |
| 32802540 | We report effective treatment of anosmia by oral corticosteroid therapy in a patient recovered from COVID-19. | 2020-08-18 |
| 32802622 | As a less toxic option, we initiated treatment with doxycycline (DOXY) very early in the course of illness. […] Eighty-five percent (85%) of patients (n=76) demonstrated clinical recovery that is defined as resolution of fever (average 3.7 days, Coeff = -0.96, p = 0.0001), resolution of SOB (average 4.2 days), and improvement of POX: average 84% before treatment and average 95% after treatment (84.7 ± 7% vs. […] Higher pre- and post-treatment POX is associated with lower mortality (oxygen saturation (Spo2) vs. […] Conclusion Early treatment with DOXY for high-risk patients with moderate to severe COVID-19 infections in non-hospital settings, such as LTCFs, is associated with early clinical recovery, decreased hospitalization, and decreased mortality. | 2020-08-18 |
| 32802693 | Humanitas Clinical and Research Hospital (Rozzano, MI, Italy) was declared a regional hub for the treatment of COVID-19 patients. | 2020-08-18 |
| 32802744 | Five research topics were identified: Data mining method based analysis on the medication law of Chinese medicine in prevention and management of COVID-19; exploration of active compounds of Chinese medicine for COVID-19 treatment based on network pharmacology and molecular docking; expert consensus and interpretation of COVID-19 treatment; research on the etiology and pathogenesis of COVID-19; and clinical research of TCM for COVID-19 treatment. | 2020-08-18 |
| 32802745 | This study aimed to introduce the Korean Medicine (KM) telemedicine center for treatment of COVID patients in Korea. […] Data on demographic characteristics, treatment frequency, number of consultation were collected. […] These results show some advantages of the telemedicine center’s implementation in terms of the effective use of medical resources and continuous treatment for patients. | 2020-08-18 |
| 32802747 | There are similar symptoms and laboratory findings with both dengue fever and COVID-19, paving way to dangerous possibilities such as incorrect or delayed initial treatment. | 2020-08-18 |
| 32802787 | Physicians and scientists around the world are aggressively attempting to develop effective treatment strategies. […] The treatment goal is to reduce the fatality rate in 15% to 20% of individuals infected with SARS-CoV-2 who develop severe inflammatory conditions that can lead to pneumonia, and acute respiratory distress syndrome. […] Convalescent plasma (CP) collected from patients recovered from the novel corona virus disease (COVID-19) has been considered as an effective treatment method for COVID-19. […] Moreover, low-dose radiation therapy (LDRT) for COVID-19 pneumonia was historically used to treat pneumonia during the first half of the 20th century. […] Later scientists from Canada, Spain, United States, Germany and France also confirmed the potential efficacy of LDRT for treatment of COVID-19 pneumonia. […] The rationale behind introducing LDRT as an effective treatment method for pneumonia in COVID-19 patients is not only due to its anti-inflammatory effect, but also in optimization of the activity of the immune system. […] Moreover, LDRT, unlike other treatment methods such as antiviral drugs, does not have the key disadvantage of exerting a significant selective pressure on the SARS-CoV-2 virus and hence does not lead to evolution of the virus through mutations. […] Given these considerations, we believe that a hybrid treatment including both CP and LDRT can trigger synergistic responses that will help healthcare providers in mitigating today’s COVID-19 pandemic. | 2020-08-18 |
| 32802824 | In the era of this pandemic, the role of medicinal nicotine in the prevention and treatment of #COVID19 disease should be evaluated in placebo-controlled trials, while smoking cessation should be further promoted as a general public health measure https://bit.ly/3fpsBdq. | 2020-08-18 |
| 32802924 | These are needed for children and the enteral nutrition of inpatients of intensive care units. | 2020-08-18 |
| 32802980 | There is an urgent need for the identification of effective therapeutics for COVID-19 and we have developed a machine learning drug discovery pipeline to identify several drug candidates. […] Prospective volatile candidates are proposed as novel inhaled therapeutics since the nasal cavity and respiratory tracts are early bottlenecks for infection. […] We anticipate that this theoretical study can accelerate testing of two categories of therapeutics: repurposed drugs suited for short-term approval, and novel efficacious drugs suitable for a long-term follow up. | 2020-08-18 |
| 32802981 | In the present work, the succinic acid (SA), L-pyroglutamic acid (L-PGA), N-phenyl-thioacetamide (N-NPTA), 2-amino-5-chloropyridine hydrogen succinate (ACPS), epigallocatechine Gallate (EGCG) or KDH and, selenomethionine (SeM) compounds have been proposed as potential antiviral candidates to treatment of COVID-19 based on B3LYP/6-311++G∗∗ calculations and molecular docking. […] From the above studies for six species we can propose that the better potential antiviral candidate to treatment of COVID-19 is ACPS and then, KDH. | 2020-08-18 |
| 32802983 | Hence, the treatment of COVID-19 using Hydroxychloroquine and Azithromycin in some patients as single dose and their combination in patients with Corona virus resistance can be more effective. | 2020-08-18 |
| 32803133 | In the light of the COVID-19 pandemic, the International Workshop on Waldenström Macroglobulinemia (IWWM) Treatment Recommendations Panel felt the need to provide a consensus statement for the management of Waldenström Macroglobulinemia (WM) patients during this challenging time. […] In this Consensus Statement, the Panel addresses questions related to treatment initiation, preferred therapies, minimizing visit to clinics and infusions centers, supportive care and guidance for WM patients in clinical trials. | 2020-08-18 |
| 32803146 | The understanding and linking of such mechanisms might help in tailoring drug repurposing for treatment or prophylaxis of COVID-19 cardiovascular complications. | 2020-08-18 |
| 32803216 | Efforts need to maintain the persistent supply of antiretroviral treatment to elderly PLWH aged 50 years or above during the COVID-19 epidemic. | 2020-08-18 |
| 32803240 | Hospitals and intensive care units were suddenly faced with a “tsunami” warning requiring instantaneous implementation and escalation of disaster plans. […] An evidence-based question was developed and an extensive review of the literature was completed, resulting in a structured plan for the intensive care units to manage a surge of patients critically ill with COVID-19 in March 2020. | 2020-08-18 |
| 32803251 | The use of antiretroviral therapy (ART) for people with HIV (PWH) has improved life expectancy. | 2020-08-18 |
| 32803422 | Initial reports on COVID-19 described children as largely spared from severe manifestations, with only 2-6% of children requiring intensive care treatment. | 2020-08-18 |
| 32803472 | Identifying people in need of mental health care and determining the appropriate psychiatric services and therapy needed will be important. | 2020-08-18 |
| 32803479 | In this review, role of EOs in the prevention and treatment of COVID-19 is discussed. | 2020-08-18 |
| 32803637 | The COVID-19 pandemic has impacted early breast cancer (EBC) treatment worldwide. […] Most of the respondents (324; 64.4%) lived in a state capital city, were board-certified as breast specialists (395; 78.5%) and either worked in an academic institute or one associated with breast cancer treatment (390; 77.5%). […] For hormone receptor-positive tumors with the best prognosis (Ki-67 < 20%), 47.9% and 17.7% of specialists would recommend neoadjuvant endocrine therapy for postmenopausal and premenopausal women, respectively. […] For tumors ≥ 1.0 cm, 42.9% of respondents would recommend neoadjuvant systemic therapy for triple-negative tumors and 39.6% for HER2 + tumors. […] Important changes occurred in EBC treatment, particularly for hormone receptor-positive tumors, as the outbreak progressed in each region. […] Systematic monitoring could assure appropriate breast cancer treatment, mitigating the impact of the pandemic. | 2020-08-18 |
| 32803662 | A survey with 57 questions was sent to NEN-dedicated Italian centers regarding the management of patients in the period March 9, 2020, to May 9, 2020 RESULTS: The main modification in the centers’ activity consisted of decreases in newly diagnosed NEN patients (- 76.8%), decreases in performed surgical procedures (- 58%), delays to starting peptide receptor radionuclide therapy (45.5%), postponed/canceled follow-up examinations (26%), and canceled multidisciplinary teams’ activity (20.8%). […] A low proportion of centers (< 10%) reported having to withdraw systemic anti-tumor medical treatment due to concerns about the pandemic situation, whereas PRRT was withdrawn from no patients. […] Although the COVID-19 outbreak induced the centers to reduce some important activities in the management of NEN patients, the Italian network was able to provide continuity in care without withdrawing anti-tumor treatment for the majority of patients. | 2020-08-18 |
| 32803670 | In this review, we discuss the most updated evidence on the pathophysiology, diagnosis, and treatment of the coagulopathy of COVID-19. | 2020-08-18 |
| 32803762 | Since the new coronavirus known as 2019-nCoV (severe acute respiratory syndrome coronavirus 2, SARS-CoV-2) has widely spread in Wuhan, China, with severe pneumonia, scientists and physicians have made remarkable efforts to use various options such as monoclonal antibodies, peptides, vaccines, small-molecule drugs and interferon therapies to control, prevent or treatment infections of 2019-nCoV. | 2020-08-18 |
| 32803988 | We report a case of a severe Clostridium difficile colitis in a post-treatment and recovered COVID-19 patient. […] An urgent pancolectomy was performed due to her bad response to conservative treatment. […] The updated criteria for severe colitis and severe C. difficile infection should be considered to ensure an early effective treatment for the complication. | 2020-08-18 |
| 32804015 | In the absence of a proven effective vaccine preventing infection by SARS-CoV-2, or a proven drug to treat COVID-19, the positive results of passive immune therapy using convalescent serum provide a strong lead. […] We have developed a new class of tetravalent, biparatopic therapy, 89C8-ACE2. | 2020-08-18 |
| 32804047 | Background: COVID-19 is a terrific pandemic and a potential risk for every health care professional (HCP), especially during emergency conditions where the right timing is essential for the correct treatment. | 2020-08-18 |
| 32804086 | The development of our RMA approach was motivated by a currently relevant clinical question: is ocular toxicity and vision compromise a side effect of hydroxychloroquine therapy? […] At the time of designing this study, hydroxychloroquine was a leading candidate in the treatment of coronavirus disease (COVID-19). | 2020-08-18 |
| 32804094 | Demographic, clinical, laboratory, radiological, and treatment data were collected and analyzed. | 2020-08-18 |
| 32804103 | This program targets patients with advanced Parkinson’s disease and related disorders, specifically those who are homebound, receiving or eligible for palliative care, and/or lacking support networks. | 2020-08-18 |
| 32804145 | The current overview aims to examine research studies showing the effect of bright light therapy (BLT) on sleep disorders and sleep-wake patterns in AD. […] Fifteen studies have been thorough: seven followed an environmental-architectural approach and eight followed a treatment devices approach. | 2020-08-18 |
| 32804279 | High-risk conditions include reduced airway clearance due to oropharyngeal weakness and risk of worsening with fever, fasting or infection Isolation requirements may have an impact on treatment regimens administered in hospital settings, such as nusinersen, glucosidase alfa, intravenous immunoglobulin, and rituximab infusions. […] In addition, specific drugs for SARS-CoV2 infection under investigation impair neuromuscular function significantly; chloroquine and azithromycin are not recommended in myasthenia gravis without available ventilatory support and prolonged prone positioning may influence options for treatment. […] Other therapeutics may affect specific NMDs (metabolic, mitochondrial, myotonic diseases) and experimental approaches for Coronavirus disease 2019 may be offered “compassionately” only after consulting the patient’s NMD specialist. | 2020-08-18 |
| 32804389 | The adaptability includes physical layout, triaging, quick testing, isolating confirmed parturients, access to designated intensive care units, facilitating emergent cesarean deliveries, and educating health care personnel. | 2020-08-18 |
| 32804456 | In each case, a treatment decision must be reached based on best clinical practices for the disorder, patient comorbidities, the current state of knowledge about the pathogenesis and infectivity of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), and the utilization of hospital and community resources. […] In this article, we review the current understanding of SARS-CoV-2 and COVID-19 complications to provide a framework for approaching the treatment of inflammatory neuro-ophthalmic disorders during the COVID-19 viral pandemic. | 2020-08-18 |
| 32804597 | So far, no approved therapy has been developed to halt the spread of the pathogen, and unfortunately, the strategies for developing a new therapy will require a long time and very extensive resources. […] Our docking documentation of 69 compounds and future research agenda assumptions were directed toward finding an effective and economic anti-COVID-19 treatment from natural products. | 2020-08-18 |
| 32804611 | This study was designed to determine whether systemic glucocorticoid treatment in COVID-19 patients is associated with reduced mortality or mechanical ventilation. […] However, glucocorticoid treatment of patients with initial C-reactive protein (CRP) ≥20 mg/dL was associated with significantly reduced risk of mortality or mechanical ventilation (odds ratio, 0.23; 95% CI, 0.08-0.70), while glucocorticoid treatment of patients with CRP <10 mg/dL was associated with significantly increased risk of mortality or mechanical ventilation (OR, 2.64; 95% CI, 1.39-5.03). […] Whether glucocorticoid treatment is associated with changes in mortality or mechanical ventilation in patients with high or low CRP needs study in prospective, randomized clinical trials. | 2020-08-18 |
| 32804669 | Early international observations report decreased number of acute ischemic stroke admissions and prolonged onset-to-treatment times during COVID-19 pandemic. […] In the COVID-period, the proportion of patients arriving beyond 24 hours after onset increased by 13% (p = 0.046), the rate of endovascular interventions remained unchanged (8%), the rate of intravenous thrombolysis decreased from 26% to 16%, the mean onset-to-treatment time of thrombolysis increased by 20 minutes, while the mean door-to-treatment time increased by only 5 minutes. […] While the rate of endovascular interventions remained unchanged, the absolute rate of intravenous thrombolysis decreased by 10% and the mean onset-to-treatment time showed a tendency to increase. | 2020-08-18 |
| 32804713 | Telerehabilitation, defined as therapy provided by physical therapy, occupational therapy, and speech and language pathology, was rapidly adopted with goals to provide access to care and limit contagion. […] Most commonly, participants were women (53.7%), 35-64 yrs old, and completed physical therapy (53.7%) for established visits of 30-44 mins in duration for primary impairments in sports, lower limb injuries, and pediatric neurology. | 2020-08-18 |
| 32804802 | Treatment for COVID-19 included frequently hydroxychloroquine, azithromycin, high dose steroids, lopinavir/ritonavir and tocilizumab. | 2020-08-18 |
| 32804917 | At present, there is no proven and efficacious treatment for this new disease. […] Ozone therapy consists of administration of a mixture of oxygen and ozone (a molecule consisting of 3 oxygen atoms). […] The potential benefits of this therapy include reduced tissue hypoxia, decreased hypercoagulability, renal and heart protection, modulated immune function, improved phagocytic function, and impaired viral replication. […] CASE REPORT We report rapidly improved hypoxia with associated decreases in inflammatory markers and D-dimer immediately after 1-4 sessions of oxygen-ozone (O₂-O₃) therapy in 3 patients with COVID-19 pneumonia who presented with respiratory failure. […] All patients were discharged home on days 3-4 after O₂-O₃ therapy. […] CONCLUSIONS O₂-O₃ therapy appears to be an effective therapy for COVID-19 patients with severe respiratory failure. […] Large controlled clinical trials are required to study the efficacy and safety of using O₂-O₃ therapy compared with the standard supportive case in patients with COVID-19 in terms of the need for invasive ventilation and length of hospital and intensive care unit stays. | 2020-08-18 |
| 32804920 | The patient had an untoward clinical course despite treatment with hydroxychloroquine, azithromycin, and corticosteroids, dying on the third day of hospitalization. | 2020-08-18 |
| 32804923 | Rehabilitation and physical therapy have been adapting to the telehealth era, increasing accessibility and improving the continuity of attention in geographically remote populations with disabilities. […] In this context, this protocol has been developed to evaluate the effectiveness of telerehabilitation as a care strategy in physical therapy for different conditions, populations, and contexts. […] It will include systematic reviews of different conditions, populations, and contexts, where the intervention to be evaluated is telerehabilitation by physical therapy. | 2020-08-18 |
| 32805004 | There is hope that AI can help guide treatment decisions within this crisis yet given the pervasiveness of biases, a failure to proactively develop comprehensive mitigation strategies during the COVID-19 pandemic risks exacerbating existing health disparities. | 2020-08-18 |
| 32805237 | The COVID-19 pandemic has accentuated the need for a coordinated, multi-pronged approach to optimize medication availability as individual or unilateral efforts are unlikely to be successful. | 2020-08-18 |
| 32805298 | Novel antibiotics have been studied for CAP and extend the choice of therapy, particularly for those who are intolerant of, or not responding to standard treatment, including those who harbor drug resistant pathogens. […] In this review, we focus on the risk factors, microbiology, site of care decisions and treatment of patients with SCAP. | 2020-08-18 |
| 32805314 | Thus, a comprehensive research is crucially needed to decode the pathogenic tools, plausible drug targets, committed to the development of efficient therapy. | 2020-08-18 |
| 32805422 | One of the hypotheses that could explain the later emergence and spread of COVID-19 pandemic in African countries is the use of antimalarial drugs to treat malaria, and specifically, artemisinin-based combination therapy (ACT). […] The antiviral activity of fixed concentrations of ACT at concentrations consistent with those observed in human plasma when ACT is administered at oral doses for uncomplicated malaria treatment was evaluatedin vitro against a clinically isolated SARS-CoV-2 strain (IHUMI-3) in Vero E6 cells. […] Mefloquine-artesunate exerted the highest antiviral activity with % inhibition of 72.1 ± 18.3 % at expected maximum blood concentration (Cmax) for each ACT drug at doses commonly administered in malaria treatment. […] Thesein vitro results reinforce the hypothesis that antimalarial drugs could be effective as an anti-COVID-19 treatment. | 2020-08-18 |
| 32805702 | Most patients (n=1306, 82.4%) received anticoagulation (either VTE prophylaxis or treatment). | 2020-08-18 |
| 32805722 | Early identification of severe patients with coronavirus disease 2019 (COVID-19) is very important for individual treatment. | 2020-08-18 |
| 32805726 | During the COVID-19 outbreak, some patients with COVID-19 pneumonia also suffered from acute abdomen requiring surgical treatment; however, there is no consensus for the treatment of such patients. | 2020-08-18 |
| 32805728 | Globally, an effective treatment for COVID-19 is still limited. […] With this bioinformatics-based report, we reveal, for the first time, the anti-SARS-CoV-2 functions and mechanisms of VA and suggest that VA may act as a potent treatment option for COVID-19, a deadly global epidemic. | 2020-08-18 |
| 32805781 | Renal replacement therapy was required in 6 of the 37 patients, 4 of whom (66 percent) died. | 2020-08-18 |
| 32806067 | Our work enhances understanding of the binding mechanism of SARS-CoV-2 to ACE2, which may aid the design of therapeutics for COVID-19 infection. | 2020-08-19 |
| 32806422 | Pollution data included three types of air emission concentrations (particulate matter<2.5 μm (PM2.5), ozone and diesel particulate matter (DPM)), and four pollution source variables (proximity to traffic, National Priority List sites, Risk Management Plan (RMP) sites, and hazardous waste treatment, storage and disposal facilities (TSDFs)). | 2020-08-19 |
| 32806699 | The study involved 441 healthcare professionals including 206 healthcare workers at emergency wards, infectious wards, and intensive care units. […] Our study showed that healthcare workers who are exposed to SARS-CoV-2-infected patients at emergency wards, infectious wards, and intensive care units are at a much higher risk of showing symptoms of anxiety, depression, and sleep disorders than healthcare workers working in other wards. | 2020-08-19 |
| 32806708 | Specifically, we have focused on various aspects, including host species, organotropism, transmission, clinical disease, pathogenesis, control and therapy, MHV as a model for SARS-CoV and SARS-CoV-2 as well as mouse models for infection with SARS-CoV and SARS-CoV-2. […] Lessons from prior murine studies on coronavirus, coupled with novel murine models could offer new promising avenues for treatment of COVID-19. | 2020-08-19 |
| 32806998 | More attention should be given to cardiovascular protection during COVID-19 treatment for mortality reduction. | 2020-08-19 |
| 32807002 | Methods and Results We retrospectively assessed 2,297 hospitalized COVID-19 patients at Tongji Hospital in Wuhan, China, from January 10th to March 30th, 2020; and identified 1,182 patients with known hypertension on pre-hospitalization therapy. | 2020-08-19 |
| 32807047 | At present, the world is facing a global pandemic threat of SARS-CoV-2 or COVID-19 and till date, there are no clinically approved vaccines or antiviral drugs available for the treatment of coronavirus infections. | 2020-08-19 |
| 32807209 | It is a safe, inexpensive, generic licenced drug available worldwide and manufactured to scale and is a potential candidate therapy for pandemic coronavirus disease 2019 (COVID-19). | 2020-08-19 |
| 32807241 | To assess the hypothesis that an adjunctive therapy with methylprednisolone and unfractionated heparin (UFH) or with methylprednisolone and low molecular weight heparin (LMWH) are more effective in reducing any-cause mortality in critically-ill ventilated patients with pneumonia from SARS-CoV-2 infection compared to LMWH alone. […] Patients, who satisfy all inclusion criteria and no exclusion criteria, will be randomly assigned to one of the three treatment groups in a ratio 1:1:1. […] Inpatients will be recruited from 8 Italian Academic and non-Academic Intensive Care Units INCLUSION CRITERIA (ALL REQUIRED): 1. […] On-going treatment with anticoagulant drugs 3. […] Active bleeding or on-going clinical condition deemed at high risk of bleeding contraindicating anticoagulant treatment 7. […] Clinical decision to withhold life-sustaining treatment or “too sick to benefit” 11. […] The treatment with UFH will be administered up to ICU discharge. […] After ICU discharge anticoagulant therapy may be interrupted or switched to prophylaxis with LMWH in the destination ward up to clinical judgement of the attending physician. […] The treatment will be administered subcutaneously once a day up to ICU discharge. | 2020-08-19 |
| 32807416 | In this scenario, managing acute medical conditions, such as stroke, requires a timely treatment together with proper strategies that minimize the risk of infection spreading to health care workers and other patients. […] We are aware that such measure results in some delay of the acute treatment of stroke, which could be minimal using well-exercised containment protocols. | 2020-08-19 |
| 32807425 | Previously established SAH treatment protocols are impractical to impossible to adhere to in the current COVID-19 crisis due to the need for infection containment and shortage of critical care resources, including personal protective equipment (PPE). | 2020-08-19 |
| 32807471 | We compared stroke quality metrics including treatment times and discharge outcomes of AIS patients during the pandemic (03/012020-05/152020) compared with a historical pre-pandemic group (6/1/2019-2/29/2020). […] After adjusting for stroke severity, age and a prior history of transient ischemic attack/stroke, pandemic patients had increased discharge mortality (adjusted OR 2.90 95% CI 1.77 - 7.17, p = 0.021) CONCLUSION: Despite unprecedented demands on emergency healthcare services, early multidisciplinary efforts to adapt the acute stroke treatment process resulted in keeping the stroke quality time metrics close to pre-pandemic levels. | 2020-08-19 |
| 32807688 | Lopinavir-interferon α2b boosted ribavirin following with lopinavir boosted budesonide might be a potent treatment for viral clearance. | 2020-08-19 |
| 32807934 | Hence, contingent upon independent validation in other COVID-19 cohorts, individual traits within this signature may collectively and individually guide treatment options; offer insights into COVID-19 pathogenesis; and aid early, risk-based patient stratification that is particularly beneficial in phasic diseases such as COVID-19. | 2020-08-19 |
| 32808089 | The Italian Society of Radiotherapy and Clinical Oncology (AIRO) identified the need of practice recommendations on logistic issues, treatment delivery and healthcare personnel’s protection in a time of limited resources. […] There was agreement or strong agreement across the majority (93%) of proposed items including treatment strategies, use of personal protection devices, set-up modifications and follow-up re-scheduling. […] Guaranteeing treatment delivery for HNC patients is well-recognized in Radiation Oncology. | 2020-08-19 |
| 32808105 | Treatment with therapeutic anticoagulation was associated with improved inpatient mortality compared with prophylactic anticoagulation alone (63% vs 86.2%, p < 0.0001) in patients requiring mechanical ventilation. | 2020-08-19 |
| 32808122 | In this article, we highlighted the pharmacological treatment strategies for COVID-19 and purposed the therapeutic targets for the development of vaccines or anti-viral drug molecules against SARS-CoV-2 infection in humans. | 2020-08-19 |
| 32808174 | They developed respiratory failure and were admitted to ICU for mechanical ventilation and intense medical treatment. | 2020-08-19 |
| 32808185 | Treatment of common co-morbidities often require chronic use of multiple medications, which may result in an additive increase in the expression of ACE2 and TMPRSS2. | 2020-08-19 |
| 32808446 | Various diagnostic approaches were developed and implemented to assist in the rapid identification of patients and treatment of their illness, yet many of the approaches required days or weeks from the onset of fever to show statistical significance. | 2020-08-19 |
| 32808459 | In conclusion, several sources of evidence have supported a relationship between GHD and COVID-19, and they also shed light upon potential beneficial effects of recombinant GH treatment on COVID-19 patients. | 2020-08-19 |
| 32808462 | The absence of specific treatment neither against SARS-CoV-2 nor against acute respiratory distress syndrome (ARDS), the most serious stage of this infection, has emphasized the need to find alternative treatments. […] Several therapeutics are currently tested and among them, mesenchymal stromal cells. | 2020-08-19 |
| 32808585 | As a result, many older adults are changing their health-seeking behavior by staying at home and resorting to informal healthcare such as the use of traditional therapies and over-the-counter medicines for self-treatment or to boost their immune system. | 2020-08-19 |
| 32808695 | A total of 67% of patients received antibiotic therapy, yet 72% did not have an obvious source of bacterial infection. | 2020-08-19 |
| 32808712 | Moreover, many adverse effects were reported with hydroxychloroquine therapy. | 2020-08-19 |
| 32808850 | Extensive, global collation of our current knowledge of SARS-CoV-2 will provide insights into novel treatment modalities, such as monoclonal antibodies, and support the development of a SARS-CoV-2 vaccine. | 2020-08-19 |
| 32808877 | Construct validity was supported by the positive correlations between the CAS-HC and measures of depression and generalized anxiety, while known groups validity was found with high CAS-HC scores exhibited by those working in emergency rooms, triage, and intensive care units. | 2020-08-19 |
| 32808940 | We suggest using colchicine, a class of drugs with low-cost, extensively tested, well-tolerated medicine as a complementary treatment for patients with COVID-19, in early stages of the disease based on knowledge of its immunomodulatory properties. | 2020-08-19 |
| 32808988 | The panel devised a framework for considering the use of immunomodulatory therapy based on an assessment of clinical disease severity and degree of multi-organ involvement combined with evidence of hyperinflammation. […] Immunomodulatory therapy is not recommended for the majority of pediatric patients, who typically develop mild or moderate COVID-19. […] The framework presented herein offers an approach to decision-making regarding immunomodulatory therapy for severe or critical pediatric COVID-19 and is informed by currently available data, while awaiting results of placebo-controlled randomized clinical trials. | 2020-08-19 |
| 32809050 | Reliable data on the course and treatment of pediatric COVID-19 (“corona virus disease 2019”) in immunosuppressed patients with rheumatic diseases are missing. […] Over 95% of the respondents did not support a preventive adaptation of the anti-rheumatic treatment during the SARS-CoV‑2 pandemic. […] Conversely, >70% of the respondents would continue the treatment with nonsteroidal anti-inflammatory drugs, hydroxychloroquine (HCQ), oral steroids, mycophenolate, IL‑1 blockade and immunoglobulins (Ig). […] In the case of inpatients 74.6% of respondents would consider targeted COVID-19 treatment. […] In stable patients with oxygen treatment (stage I) HCQ (18.3%), azithromycin (16.9%) and Ig (9.9%) were most frequently used. […] Therefore, the presented results have to be interpreted with caution and mostly as hypothetical treatment considerations. […] It is to be expected that there will always be a limited amount of evidence on pediatric COVID-19; therefore, a continuous and critical exchange of expert opinions on the treatment strategies is important. | 2020-08-19 |
| 32809060 | We undertook an evaluation of differences in COVID-19 symptom occurrence rates, COVID-19 testing rates, clinical care activities, knowledge of COVID-19, and use of mitigation procedures between patients who were and were not receiving active cancer treatment. […] Of the 174 patients who participated, 27.6% (n = 48) were receiving active treatment, 13.6% were unemployed because of COVID-19, 12.2% had been tested for COVID-19, and 0.6% had been hospitalized for COVID-19. […] Patients who were not on active treatment reported a higher mean number of COVID-19 symptoms (3.1 (± 4.2) versus 1.9 (± 2.6)), and patients who reported a higher number of COVID-19 symptoms were more likely to be tested. […] For patients on active treatment, clinicians face challenges with how to assess and manage symptoms that, prior to COVID-19, would be ascribed to acute toxicities associated with cancer treatments or persistent symptoms in cancer survivors. | 2020-08-19 |
| 32809158 | Hence, we review the pathogenesis and therapy of COVID 19-related thrombosis disease, focusing on the available evidence on the possible treatment strategies and proposing an algorithm for the anticoagulation strategy based on disease severity. | 2020-08-19 |
| 32809210 | The quality of early evidence favoring the different treatment options needs to be apprised for informed decision-making. […] In this systematic literature review, we apprised the quality of available evidence for different therapeutic options and also the basis for different treatment guidelines. […] Further clinical evidence from the ongoing trials may lead to evolution of treatment guidelines with the addition of more therapeutic options. | 2020-08-19 |
| 32809870 | The core treatment strategy to manage the pulmonary phase includes the combination of methylprednisolone, ascorbic acid, thiamine, and heparin (MATH+ protocol). […] We provide an overview on the pathophysiological changes occurring in patients with COVID-19 respiratory failure and a treatment strategy to reverse these changes thereby preventing progressive lung injury and death. | 2020-08-19 |
| 32809889 | The article describes how adolescents with cancer utilized an artistic approach to discuss about their social isolation caused by disease and treatment. | 2020-08-19 |
| 32809910 | We present practical infection control guidelines to lessen the burden of dental professionals in resource poor countries who dispense treatment under trying circumstance. | 2020-08-19 |
| 32809918 | Here, we are proposing intravenous oxytocin (OXT) as a candidate for adjunctive therapy for COVID-19. […] Our results also suggest that carbetocin is more effective at inducing immune cell responses than either lopinavir or hydroxychloroquine, both of which have been explored for the treatment of COVID-19. | 2020-08-19 |
| 32809963 | Conclusions He was treated for DKA and COVID-19 infection, and fortunately, had a good response to the treatment. | 2020-08-19 |
| 32810081 | At present, an effective treatment regimen and vaccination has not been established. […] Endotracheal suctioning was performed prior to medication administration. | 2020-08-19 |
| 32810285 | Several therapeutic agents have been investigated for treatment of novel coronavirus 2019 (nCOV-2019). […] We conducted a systematic review and meta-analysis to assess the efficacy of various treatment modalities in nCOV-2019 patients. […] Our meta-analysis suggests that except in vitro studies, no treatment has shown overall favourable outcomes in nCOV-2019 patients. | 2020-08-19 |
| 32810386 | We explore how services in oncology have transformed to deliver services including consultations, systemic anticancer therapy, and surgery for patients, while shielding them from contracting COVID-19. […] The long-term effects are yet to be seen, such as safety of home-based treatment, and effectiveness of virtual communication on patient care. | 2020-08-19 |
| 32810426 | Materials and Methods: A multidisciplinary strategy has been adopted to allocate HCC patients to a treatment that permitted to reduce the risk of complications and the hospital stay, thus preventing contamination by the virus. […] [Figure: see text] Conclusions: An adapted algorithm for the treatment of HCC to COVID outbreak permitted to manage safely these patients by identifying those most at risk of evolution of the neoplastic disease. | 2020-08-19 |
| 32810426 | Materials and Methods: A multidisciplinary strategy has been adopted to allocate HCC patients to a treatment that permitted to reduce the risk of complications and the hospital stay, thus preventing contamination by the virus. […] [Figure: see text] Conclusions: An adapted algorithm for the treatment of HCC to COVID outbreak permitted to manage safely these patients by identifying those most at risk of evolution of the neoplastic disease. | 2020-08-19 |
| 32810426 | Materials and Methods: A multidisciplinary strategy has been adopted to allocate HCC patients to a treatment that permitted to reduce the risk of complications and the hospital stay, thus preventing contamination by the virus. […] [Figure: see text] Conclusions: An adapted algorithm for the treatment of HCC to COVID outbreak permitted to manage safely these patients by identifying those most at risk of evolution of the neoplastic disease. | 2020-08-19 |
| 32810426 | Materials and Methods: A multidisciplinary strategy has been adopted to allocate HCC patients to a treatment that permitted to reduce the risk of complications and the hospital stay, thus preventing contamination by the virus. […] [Figure: see text] Conclusions: An adapted algorithm for the treatment of HCC to COVID outbreak permitted to manage safely these patients by identifying those most at risk of evolution of the neoplastic disease. | 2020-08-19 |
| 32810426 | Materials and Methods: A multidisciplinary strategy has been adopted to allocate HCC patients to a treatment that permitted to reduce the risk of complications and the hospital stay, thus preventing contamination by the virus. […] [Figure: see text] Conclusions: An adapted algorithm for the treatment of HCC to COVID outbreak permitted to manage safely these patients by identifying those most at risk of evolution of the neoplastic disease. | 2020-08-19 |
| 32810426 | Materials and Methods: A multidisciplinary strategy has been adopted to allocate HCC patients to a treatment that permitted to reduce the risk of complications and the hospital stay, thus preventing contamination by the virus. […] [Figure: see text] Conclusions: An adapted algorithm for the treatment of HCC to COVID outbreak permitted to manage safely these patients by identifying those most at risk of evolution of the neoplastic disease. | 2020-08-19 |
| 32810426 | Materials and Methods: A multidisciplinary strategy has been adopted to allocate HCC patients to a treatment that permitted to reduce the risk of complications and the hospital stay, thus preventing contamination by the virus. […] [Figure: see text] Conclusions: An adapted algorithm for the treatment of HCC to COVID outbreak permitted to manage safely these patients by identifying those most at risk of evolution of the neoplastic disease. | 2020-08-19 |
| 32810426 | Materials and Methods: A multidisciplinary strategy has been adopted to allocate HCC patients to a treatment that permitted to reduce the risk of complications and the hospital stay, thus preventing contamination by the virus. […] [Figure: see text] Conclusions: An adapted algorithm for the treatment of HCC to COVID outbreak permitted to manage safely these patients by identifying those most at risk of evolution of the neoplastic disease. | 2020-08-19 |
| 32810426 | Materials and Methods: A multidisciplinary strategy has been adopted to allocate HCC patients to a treatment that permitted to reduce the risk of complications and the hospital stay, thus preventing contamination by the virus. […] [Figure: see text] Conclusions: An adapted algorithm for the treatment of HCC to COVID outbreak permitted to manage safely these patients by identifying those most at risk of evolution of the neoplastic disease. | 2020-08-19 |
| 32810426 | Materials and Methods: A multidisciplinary strategy has been adopted to allocate HCC patients to a treatment that permitted to reduce the risk of complications and the hospital stay, thus preventing contamination by the virus. […] [Figure: see text] Conclusions: An adapted algorithm for the treatment of HCC to COVID outbreak permitted to manage safely these patients by identifying those most at risk of evolution of the neoplastic disease. | 2020-08-19 |
| 32810426 | Materials and Methods: A multidisciplinary strategy has been adopted to allocate HCC patients to a treatment that permitted to reduce the risk of complications and the hospital stay, thus preventing contamination by the virus. […] [Figure: see text] Conclusions: An adapted algorithm for the treatment of HCC to COVID outbreak permitted to manage safely these patients by identifying those most at risk of evolution of the neoplastic disease. | 2020-08-19 |
| 32810426 | Materials and Methods: A multidisciplinary strategy has been adopted to allocate HCC patients to a treatment that permitted to reduce the risk of complications and the hospital stay, thus preventing contamination by the virus. […] [Figure: see text] Conclusions: An adapted algorithm for the treatment of HCC to COVID outbreak permitted to manage safely these patients by identifying those most at risk of evolution of the neoplastic disease. | 2020-08-19 |
| 32810426 | Materials and Methods: A multidisciplinary strategy has been adopted to allocate HCC patients to a treatment that permitted to reduce the risk of complications and the hospital stay, thus preventing contamination by the virus. […] [Figure: see text] Conclusions: An adapted algorithm for the treatment of HCC to COVID outbreak permitted to manage safely these patients by identifying those most at risk of evolution of the neoplastic disease. | 2020-08-19 |
| 32810426 | Materials and Methods: A multidisciplinary strategy has been adopted to allocate HCC patients to a treatment that permitted to reduce the risk of complications and the hospital stay, thus preventing contamination by the virus. […] [Figure: see text] Conclusions: An adapted algorithm for the treatment of HCC to COVID outbreak permitted to manage safely these patients by identifying those most at risk of evolution of the neoplastic disease. | 2020-08-19 |
| 32810426 | Materials and Methods: A multidisciplinary strategy has been adopted to allocate HCC patients to a treatment that permitted to reduce the risk of complications and the hospital stay, thus preventing contamination by the virus. […] [Figure: see text] Conclusions: An adapted algorithm for the treatment of HCC to COVID outbreak permitted to manage safely these patients by identifying those most at risk of evolution of the neoplastic disease. | 2020-08-19 |
| 32810426 | Materials and Methods: A multidisciplinary strategy has been adopted to allocate HCC patients to a treatment that permitted to reduce the risk of complications and the hospital stay, thus preventing contamination by the virus. […] [Figure: see text] Conclusions: An adapted algorithm for the treatment of HCC to COVID outbreak permitted to manage safely these patients by identifying those most at risk of evolution of the neoplastic disease. | 2020-08-19 |
| 32810426 | Materials and Methods: A multidisciplinary strategy has been adopted to allocate HCC patients to a treatment that permitted to reduce the risk of complications and the hospital stay, thus preventing contamination by the virus. […] [Figure: see text] Conclusions: An adapted algorithm for the treatment of HCC to COVID outbreak permitted to manage safely these patients by identifying those most at risk of evolution of the neoplastic disease. | 2020-08-19 |
| 32810426 | Materials and Methods: A multidisciplinary strategy has been adopted to allocate HCC patients to a treatment that permitted to reduce the risk of complications and the hospital stay, thus preventing contamination by the virus. […] [Figure: see text] Conclusions: An adapted algorithm for the treatment of HCC to COVID outbreak permitted to manage safely these patients by identifying those most at risk of evolution of the neoplastic disease. | 2020-08-19 |
| 32810426 | Materials and Methods: A multidisciplinary strategy has been adopted to allocate HCC patients to a treatment that permitted to reduce the risk of complications and the hospital stay, thus preventing contamination by the virus. […] [Figure: see text] Conclusions: An adapted algorithm for the treatment of HCC to COVID outbreak permitted to manage safely these patients by identifying those most at risk of evolution of the neoplastic disease. | 2020-08-19 |
| 32810426 | Materials and Methods: A multidisciplinary strategy has been adopted to allocate HCC patients to a treatment that permitted to reduce the risk of complications and the hospital stay, thus preventing contamination by the virus. […] [Figure: see text] Conclusions: An adapted algorithm for the treatment of HCC to COVID outbreak permitted to manage safely these patients by identifying those most at risk of evolution of the neoplastic disease. | 2020-08-19 |
| 32810426 | Materials and Methods: A multidisciplinary strategy has been adopted to allocate HCC patients to a treatment that permitted to reduce the risk of complications and the hospital stay, thus preventing contamination by the virus. […] [Figure: see text] Conclusions: An adapted algorithm for the treatment of HCC to COVID outbreak permitted to manage safely these patients by identifying those most at risk of evolution of the neoplastic disease. | 2020-08-19 |
| 32810426 | Materials and Methods: A multidisciplinary strategy has been adopted to allocate HCC patients to a treatment that permitted to reduce the risk of complications and the hospital stay, thus preventing contamination by the virus. […] [Figure: see text] Conclusions: An adapted algorithm for the treatment of HCC to COVID outbreak permitted to manage safely these patients by identifying those most at risk of evolution of the neoplastic disease. | 2020-08-19 |
| 32810426 | Materials and Methods: A multidisciplinary strategy has been adopted to allocate HCC patients to a treatment that permitted to reduce the risk of complications and the hospital stay, thus preventing contamination by the virus. […] [Figure: see text] Conclusions: An adapted algorithm for the treatment of HCC to COVID outbreak permitted to manage safely these patients by identifying those most at risk of evolution of the neoplastic disease. | 2020-08-19 |
| 32810426 | Materials and Methods: A multidisciplinary strategy has been adopted to allocate HCC patients to a treatment that permitted to reduce the risk of complications and the hospital stay, thus preventing contamination by the virus. […] [Figure: see text] Conclusions: An adapted algorithm for the treatment of HCC to COVID outbreak permitted to manage safely these patients by identifying those most at risk of evolution of the neoplastic disease. | 2020-08-19 |
| 32810426 | Materials and Methods: A multidisciplinary strategy has been adopted to allocate HCC patients to a treatment that permitted to reduce the risk of complications and the hospital stay, thus preventing contamination by the virus. […] [Figure: see text] Conclusions: An adapted algorithm for the treatment of HCC to COVID outbreak permitted to manage safely these patients by identifying those most at risk of evolution of the neoplastic disease. | 2020-08-19 |
| 32810426 | Materials and Methods: A multidisciplinary strategy has been adopted to allocate HCC patients to a treatment that permitted to reduce the risk of complications and the hospital stay, thus preventing contamination by the virus. […] [Figure: see text] Conclusions: An adapted algorithm for the treatment of HCC to COVID outbreak permitted to manage safely these patients by identifying those most at risk of evolution of the neoplastic disease. | 2020-08-19 |
| 32810426 | Materials and Methods: A multidisciplinary strategy has been adopted to allocate HCC patients to a treatment that permitted to reduce the risk of complications and the hospital stay, thus preventing contamination by the virus. […] [Figure: see text] Conclusions: An adapted algorithm for the treatment of HCC to COVID outbreak permitted to manage safely these patients by identifying those most at risk of evolution of the neoplastic disease. | 2020-08-19 |
| 32810426 | Materials and Methods: A multidisciplinary strategy has been adopted to allocate HCC patients to a treatment that permitted to reduce the risk of complications and the hospital stay, thus preventing contamination by the virus. […] [Figure: see text] Conclusions: An adapted algorithm for the treatment of HCC to COVID outbreak permitted to manage safely these patients by identifying those most at risk of evolution of the neoplastic disease. | 2020-08-19 |
| 32810426 | Materials and Methods: A multidisciplinary strategy has been adopted to allocate HCC patients to a treatment that permitted to reduce the risk of complications and the hospital stay, thus preventing contamination by the virus. […] [Figure: see text] Conclusions: An adapted algorithm for the treatment of HCC to COVID outbreak permitted to manage safely these patients by identifying those most at risk of evolution of the neoplastic disease. | 2020-08-19 |
| 32810426 | Materials and Methods: A multidisciplinary strategy has been adopted to allocate HCC patients to a treatment that permitted to reduce the risk of complications and the hospital stay, thus preventing contamination by the virus. […] [Figure: see text] Conclusions: An adapted algorithm for the treatment of HCC to COVID outbreak permitted to manage safely these patients by identifying those most at risk of evolution of the neoplastic disease. | 2020-08-19 |
| 32810426 | Materials and Methods: A multidisciplinary strategy has been adopted to allocate HCC patients to a treatment that permitted to reduce the risk of complications and the hospital stay, thus preventing contamination by the virus. […] [Figure: see text] Conclusions: An adapted algorithm for the treatment of HCC to COVID outbreak permitted to manage safely these patients by identifying those most at risk of evolution of the neoplastic disease. | 2020-08-19 |
| 32810426 | Materials and Methods: A multidisciplinary strategy has been adopted to allocate HCC patients to a treatment that permitted to reduce the risk of complications and the hospital stay, thus preventing contamination by the virus. […] [Figure: see text] Conclusions: An adapted algorithm for the treatment of HCC to COVID outbreak permitted to manage safely these patients by identifying those most at risk of evolution of the neoplastic disease. | 2020-08-19 |
| 32810426 | Materials and Methods: A multidisciplinary strategy has been adopted to allocate HCC patients to a treatment that permitted to reduce the risk of complications and the hospital stay, thus preventing contamination by the virus. […] [Figure: see text] Conclusions: An adapted algorithm for the treatment of HCC to COVID outbreak permitted to manage safely these patients by identifying those most at risk of evolution of the neoplastic disease. | 2020-08-19 |
| 32810426 | Materials and Methods: A multidisciplinary strategy has been adopted to allocate HCC patients to a treatment that permitted to reduce the risk of complications and the hospital stay, thus preventing contamination by the virus. […] [Figure: see text] Conclusions: An adapted algorithm for the treatment of HCC to COVID outbreak permitted to manage safely these patients by identifying those most at risk of evolution of the neoplastic disease. | 2020-08-19 |
| 32810426 | Materials and Methods: A multidisciplinary strategy has been adopted to allocate HCC patients to a treatment that permitted to reduce the risk of complications and the hospital stay, thus preventing contamination by the virus. […] [Figure: see text] Conclusions: An adapted algorithm for the treatment of HCC to COVID outbreak permitted to manage safely these patients by identifying those most at risk of evolution of the neoplastic disease. | 2020-08-19 |
| 32810426 | Materials and Methods: A multidisciplinary strategy has been adopted to allocate HCC patients to a treatment that permitted to reduce the risk of complications and the hospital stay, thus preventing contamination by the virus. […] [Figure: see text] Conclusions: An adapted algorithm for the treatment of HCC to COVID outbreak permitted to manage safely these patients by identifying those most at risk of evolution of the neoplastic disease. | 2020-08-19 |
| 32810426 | Materials and Methods: A multidisciplinary strategy has been adopted to allocate HCC patients to a treatment that permitted to reduce the risk of complications and the hospital stay, thus preventing contamination by the virus. […] [Figure: see text] Conclusions: An adapted algorithm for the treatment of HCC to COVID outbreak permitted to manage safely these patients by identifying those most at risk of evolution of the neoplastic disease. | 2020-08-19 |
| 32810426 | Materials and Methods: A multidisciplinary strategy has been adopted to allocate HCC patients to a treatment that permitted to reduce the risk of complications and the hospital stay, thus preventing contamination by the virus. […] [Figure: see text] Conclusions: An adapted algorithm for the treatment of HCC to COVID outbreak permitted to manage safely these patients by identifying those most at risk of evolution of the neoplastic disease. | 2020-08-19 |
| 32810426 | Materials and Methods: A multidisciplinary strategy has been adopted to allocate HCC patients to a treatment that permitted to reduce the risk of complications and the hospital stay, thus preventing contamination by the virus. […] [Figure: see text] Conclusions: An adapted algorithm for the treatment of HCC to COVID outbreak permitted to manage safely these patients by identifying those most at risk of evolution of the neoplastic disease. | 2020-08-19 |
| 32810426 | Materials and Methods: A multidisciplinary strategy has been adopted to allocate HCC patients to a treatment that permitted to reduce the risk of complications and the hospital stay, thus preventing contamination by the virus. […] [Figure: see text] Conclusions: An adapted algorithm for the treatment of HCC to COVID outbreak permitted to manage safely these patients by identifying those most at risk of evolution of the neoplastic disease. | 2020-08-19 |
| 32810426 | Materials and Methods: A multidisciplinary strategy has been adopted to allocate HCC patients to a treatment that permitted to reduce the risk of complications and the hospital stay, thus preventing contamination by the virus. […] [Figure: see text] Conclusions: An adapted algorithm for the treatment of HCC to COVID outbreak permitted to manage safely these patients by identifying those most at risk of evolution of the neoplastic disease. | 2020-08-19 |
| 32810426 | Materials and Methods: A multidisciplinary strategy has been adopted to allocate HCC patients to a treatment that permitted to reduce the risk of complications and the hospital stay, thus preventing contamination by the virus. […] [Figure: see text] Conclusions: An adapted algorithm for the treatment of HCC to COVID outbreak permitted to manage safely these patients by identifying those most at risk of evolution of the neoplastic disease. | 2020-08-19 |
| 32810426 | Materials and Methods: A multidisciplinary strategy has been adopted to allocate HCC patients to a treatment that permitted to reduce the risk of complications and the hospital stay, thus preventing contamination by the virus. […] [Figure: see text] Conclusions: An adapted algorithm for the treatment of HCC to COVID outbreak permitted to manage safely these patients by identifying those most at risk of evolution of the neoplastic disease. | 2020-08-19 |
| 32810426 | Materials and Methods: A multidisciplinary strategy has been adopted to allocate HCC patients to a treatment that permitted to reduce the risk of complications and the hospital stay, thus preventing contamination by the virus. […] [Figure: see text] Conclusions: An adapted algorithm for the treatment of HCC to COVID outbreak permitted to manage safely these patients by identifying those most at risk of evolution of the neoplastic disease. | 2020-08-19 |
| 32810426 | Materials and Methods: A multidisciplinary strategy has been adopted to allocate HCC patients to a treatment that permitted to reduce the risk of complications and the hospital stay, thus preventing contamination by the virus. […] [Figure: see text] Conclusions: An adapted algorithm for the treatment of HCC to COVID outbreak permitted to manage safely these patients by identifying those most at risk of evolution of the neoplastic disease. | 2020-08-19 |
| 32810426 | Materials and Methods: A multidisciplinary strategy has been adopted to allocate HCC patients to a treatment that permitted to reduce the risk of complications and the hospital stay, thus preventing contamination by the virus. […] [Figure: see text] Conclusions: An adapted algorithm for the treatment of HCC to COVID outbreak permitted to manage safely these patients by identifying those most at risk of evolution of the neoplastic disease. | 2020-08-19 |
| 32810426 | Materials and Methods: A multidisciplinary strategy has been adopted to allocate HCC patients to a treatment that permitted to reduce the risk of complications and the hospital stay, thus preventing contamination by the virus. […] [Figure: see text] Conclusions: An adapted algorithm for the treatment of HCC to COVID outbreak permitted to manage safely these patients by identifying those most at risk of evolution of the neoplastic disease. | 2020-08-19 |
| 32810426 | Materials and Methods: A multidisciplinary strategy has been adopted to allocate HCC patients to a treatment that permitted to reduce the risk of complications and the hospital stay, thus preventing contamination by the virus. […] [Figure: see text] Conclusions: An adapted algorithm for the treatment of HCC to COVID outbreak permitted to manage safely these patients by identifying those most at risk of evolution of the neoplastic disease. | 2020-08-19 |
| 32810426 | Materials and Methods: A multidisciplinary strategy has been adopted to allocate HCC patients to a treatment that permitted to reduce the risk of complications and the hospital stay, thus preventing contamination by the virus. […] [Figure: see text] Conclusions: An adapted algorithm for the treatment of HCC to COVID outbreak permitted to manage safely these patients by identifying those most at risk of evolution of the neoplastic disease. | 2020-08-19 |
| 32810426 | Materials and Methods: A multidisciplinary strategy has been adopted to allocate HCC patients to a treatment that permitted to reduce the risk of complications and the hospital stay, thus preventing contamination by the virus. […] [Figure: see text] Conclusions: An adapted algorithm for the treatment of HCC to COVID outbreak permitted to manage safely these patients by identifying those most at risk of evolution of the neoplastic disease. | 2020-08-19 |
| 32810426 | Materials and Methods: A multidisciplinary strategy has been adopted to allocate HCC patients to a treatment that permitted to reduce the risk of complications and the hospital stay, thus preventing contamination by the virus. […] [Figure: see text] Conclusions: An adapted algorithm for the treatment of HCC to COVID outbreak permitted to manage safely these patients by identifying those most at risk of evolution of the neoplastic disease. | 2020-08-19 |
| 32810426 | Materials and Methods: A multidisciplinary strategy has been adopted to allocate HCC patients to a treatment that permitted to reduce the risk of complications and the hospital stay, thus preventing contamination by the virus. […] [Figure: see text] Conclusions: An adapted algorithm for the treatment of HCC to COVID outbreak permitted to manage safely these patients by identifying those most at risk of evolution of the neoplastic disease. | 2020-08-19 |
| 32810426 | Materials and Methods: A multidisciplinary strategy has been adopted to allocate HCC patients to a treatment that permitted to reduce the risk of complications and the hospital stay, thus preventing contamination by the virus. […] [Figure: see text] Conclusions: An adapted algorithm for the treatment of HCC to COVID outbreak permitted to manage safely these patients by identifying those most at risk of evolution of the neoplastic disease. | 2020-08-19 |
| 32810426 | Materials and Methods: A multidisciplinary strategy has been adopted to allocate HCC patients to a treatment that permitted to reduce the risk of complications and the hospital stay, thus preventing contamination by the virus. […] [Figure: see text] Conclusions: An adapted algorithm for the treatment of HCC to COVID outbreak permitted to manage safely these patients by identifying those most at risk of evolution of the neoplastic disease. | 2020-08-19 |
| 32810426 | Materials and Methods: A multidisciplinary strategy has been adopted to allocate HCC patients to a treatment that permitted to reduce the risk of complications and the hospital stay, thus preventing contamination by the virus. […] [Figure: see text] Conclusions: An adapted algorithm for the treatment of HCC to COVID outbreak permitted to manage safely these patients by identifying those most at risk of evolution of the neoplastic disease. | 2020-08-19 |
| 32810426 | Materials and Methods: A multidisciplinary strategy has been adopted to allocate HCC patients to a treatment that permitted to reduce the risk of complications and the hospital stay, thus preventing contamination by the virus. […] [Figure: see text] Conclusions: An adapted algorithm for the treatment of HCC to COVID outbreak permitted to manage safely these patients by identifying those most at risk of evolution of the neoplastic disease. | 2020-08-19 |
| 32810426 | Materials and Methods: A multidisciplinary strategy has been adopted to allocate HCC patients to a treatment that permitted to reduce the risk of complications and the hospital stay, thus preventing contamination by the virus. […] [Figure: see text] Conclusions: An adapted algorithm for the treatment of HCC to COVID outbreak permitted to manage safely these patients by identifying those most at risk of evolution of the neoplastic disease. | 2020-08-19 |
| 32810426 | Materials and Methods: A multidisciplinary strategy has been adopted to allocate HCC patients to a treatment that permitted to reduce the risk of complications and the hospital stay, thus preventing contamination by the virus. […] [Figure: see text] Conclusions: An adapted algorithm for the treatment of HCC to COVID outbreak permitted to manage safely these patients by identifying those most at risk of evolution of the neoplastic disease. | 2020-08-19 |
| 32810426 | Materials and Methods: A multidisciplinary strategy has been adopted to allocate HCC patients to a treatment that permitted to reduce the risk of complications and the hospital stay, thus preventing contamination by the virus. […] [Figure: see text] Conclusions: An adapted algorithm for the treatment of HCC to COVID outbreak permitted to manage safely these patients by identifying those most at risk of evolution of the neoplastic disease. | 2020-08-19 |
| 32810426 | Materials and Methods: A multidisciplinary strategy has been adopted to allocate HCC patients to a treatment that permitted to reduce the risk of complications and the hospital stay, thus preventing contamination by the virus. […] [Figure: see text] Conclusions: An adapted algorithm for the treatment of HCC to COVID outbreak permitted to manage safely these patients by identifying those most at risk of evolution of the neoplastic disease. | 2020-08-19 |
| 32810426 | Materials and Methods: A multidisciplinary strategy has been adopted to allocate HCC patients to a treatment that permitted to reduce the risk of complications and the hospital stay, thus preventing contamination by the virus. […] [Figure: see text] Conclusions: An adapted algorithm for the treatment of HCC to COVID outbreak permitted to manage safely these patients by identifying those most at risk of evolution of the neoplastic disease. | 2020-08-19 |
| 32810426 | Materials and Methods: A multidisciplinary strategy has been adopted to allocate HCC patients to a treatment that permitted to reduce the risk of complications and the hospital stay, thus preventing contamination by the virus. […] [Figure: see text] Conclusions: An adapted algorithm for the treatment of HCC to COVID outbreak permitted to manage safely these patients by identifying those most at risk of evolution of the neoplastic disease. | 2020-08-19 |
| 32810426 | Materials and Methods: A multidisciplinary strategy has been adopted to allocate HCC patients to a treatment that permitted to reduce the risk of complications and the hospital stay, thus preventing contamination by the virus. […] [Figure: see text] Conclusions: An adapted algorithm for the treatment of HCC to COVID outbreak permitted to manage safely these patients by identifying those most at risk of evolution of the neoplastic disease. | 2020-08-19 |
| 32810426 | Materials and Methods: A multidisciplinary strategy has been adopted to allocate HCC patients to a treatment that permitted to reduce the risk of complications and the hospital stay, thus preventing contamination by the virus. […] [Figure: see text] Conclusions: An adapted algorithm for the treatment of HCC to COVID outbreak permitted to manage safely these patients by identifying those most at risk of evolution of the neoplastic disease. | 2020-08-19 |
| 32810602 | In this regard, identifying HLA-SARS-CoV-2 peptides binding differences between individuals would help to clarify the heterogeneity of clinical responses to the disease and will also be useful to guide a personalized treatment according to its particular risk. | 2020-08-19 |
| 32810844 | Secondly, treatment planning has needed to take into account the risk to patients and/or staff of nosocomial transmission of the virus. | 2020-08-19 |
| 32810953 | Objective: To understand the treatment status and effects on colorectal cancer (CRC) patients in China during the COVID-19 pandemic, and provide evidence for decision-making for health-care workers. […] Their basic and treatment information during the COVID-19 were collected and associated effects on treatment, nursing, state of psychology and needs of social support were analyzed. […] The treatment or follow up of 896 (78.1%) CRC patients were affected during the COVID-19 outbreak. […] A total of 253 patients (22.1%) had their treatment regiments changed, of whom 141 (12.3%) had their chemotherapy regiments postponed or changed, and 83 patients (7.2%) had their surgical treatment affected. […] Conclusions: The COVID-19 epidemic has effect on the integrated treatment of CRC patients include diagnosis, treatment, examination and prognosis. […] While protecting CRC patients from being infected with SARS-CoV-2, health-care workers should also actively help them to receive timely and correct treatment and pay attention to their nursing, nutritional, psychological and social support needs in the COVID-19 epidemic. | 2020-08-19 |
| 32811324 | To investigate patient preferences for treatment settings in the light of the current pandemic. […] During the pandemic 38 (80.9 %) wanted to continue their treatment at home, but after the pandemic 22 (46.8 %) would opt to go back to the hospital. | 2020-08-20 |
| 32811354 | Vitamin D (VD) and its metabolites have been used as a palliative treatment for chronic inflammatory and infectious diseases from ancient times. | 2020-08-20 |
| 32811367 | Many studies have targeted this enzyme by small molecule inhibitors to develop therapeutics against the highly infectious disease Covid-19. […] They interacted with excellent efficiency with the chief active site residue Cys145 and thus seem to possess the remarkable potential to act as drug candidates for the treatment of Covid-19. | 2020-08-20 |
| 32811406 | Findings will be fed back rapidly to the researchers interested in COVID 19 and support the evidence and potential of possible therapeutics and small molecules with their mode of action. | 2020-08-20 |
| 32811531 | No therapeutics have yet been proven effective for treating severe COVID-19. […] To determine whether human umbilical cord mesenchymal stem cell infusion may be effective and safe for the treatment of severe COVID-19. […] Patients with severe COVID-19 were randomly divided into 2 groups: the standard treatment group and the standard treatment plus hUC-MSC infusion group. […] The incidence of progression from severe to critical illness and the 28-day mortality rate were 0 in the hUC-MSC treatment group, while 4 patients in the control group deteriorated to critical condition and received invasive ventilation; 3 of them died, and the 28-day mortality rate was 10.34%. […] In the hUC-MSC treatment group, the time to clinical improvement was shorter than that in the control group. […] Intravenous transplantation of hUC-MSCs is a safe and effective method that can be considered a salvage and priority treatment option for severe COVID-19. | 2020-08-20 |
| 32811575 | Preliminary evidence from the rapidly progressing field of psychedelic science shows that psilocybin therapy offers a promising transdiagnostic treatment strategy for a range of disorders with restricted and maladaptive habitual patterns of cognition and behaviour, notably depression, addiction and obsessive compulsive disorder. […] The COMPASS Pathways (COMPASS) phase 2b double-blind trial of psilocybin therapy in antidepressant-free, treatment-resistant depression (TRD) is underway to determine the safety, efficacy and optimal dose of psilocybin. […] Results from the Imperial College London Psilodep-RCT comparing the efficacy and mechanisms of action of psilocybin therapy to the selective serotonin reuptake inhibitor (SSRI) escitalopram will soon be published. […] However, the efficacy and safety of psilocybin therapy in conjunction with SSRIs in TRD is not yet known. […] An additional COMPASS study, with a centre in Dublin, will begin to address this question, with potential implications for the future delivery of psilocybin therapy. […] While at a relatively early stage of clinical development, and notwithstanding the immense challenges of COVID-19, psilocybin therapy has the potential to play an important therapeutic role for various psychiatric disorders in post-COVID-19 clinical psychiatry. | 2020-08-20 |
| 32811589 | Electroconvulsive therapy (ECT) is an essential treatment for severe mental illnesses such as depression with suicidality and catatonia. | 2020-08-20 |
| 32811627 | Clinical trials represent an essential component of improving treatment for substance use disorders (SUD). […] While challenges remain, it will be important to assessing the impact of these changes with regard to participant experiences and treatment outcomes. | 2020-08-20 |
| 32811670 | Our study suggests that clinicians should pay more attention to the monitoring and treatment of COVID-19 patients with DM. | 2020-08-20 |
| 32811723 | This may have resulted from patient adherence to government guidelines “Stay at home”, successful triaging of patients in primary care and emergency treatment provided by urgent dental care centres. […] Proportionally more patients who presented to hospital had received prior antibiotic therapy and required in-patient admission. | 2020-08-20 |
| 32811801 | The proportions (95% confidence interval) of patients requiring any form of oxygen therapy, oxygen therapy by high-flow nasal cannula and invasive mechanical ventilation were 77, 21.7 and 25.5 per cent, respectively, within 24 h of hospital admission. | 2020-08-20 |
| 32811804 | Because clinical diagnosis of ARDS includes several diseases, understanding the characteristics of COVID-19-related ARDS is necessary for precise treatment. […] Following treatment with antiviral medications and supportive measures, the patient was weaned off ECMO after 20 days. […] He was administered systemic steroid therapy for ARDS and extubated after 6 days. […] CONCLUSIONS Because the pattern of symptom exacerbation in COVID-19-associated pneumonia cases seems inconsistent, individual treatment management, especially the CT-based treatment strategy, is crucial. | 2020-08-20 |
| 32811936 | COVID-19 (also known as coronavirus) has had a profound impact on dentistry, with all elective treatment grinding to a halt initially and a slow phased return to normal services. […] If treatment is required, this is based on minimum intervention and avoidance of aerosol generating procedures (AGPs) on patients who are free of COVID-19. […] COVID-19-positive or suspected patients still require treatment at designated Urgent Dental Care centres.The aim of this article is to provide an insight into the COVID-19 pandemic and its implications on current emergency dental care. | 2020-08-20 |
| 32811949 | In addition to these, there are patients who had treatment suspended partway through their treatment plans and therefore there is now a backlog of patients awaiting dental care. | 2020-08-20 |
| 32812025 | Repurposing existing pharmaceuticals provides an immediate treatment opportunity. […] Larger randomized trials should be conducted to investigate this treatment further. | 2020-08-20 |
| 32812039 | Currently no effective antiviral therapy has been found to treat COVID-19. […] Patients were randomized into a treatment arm receiving sofosbuvir and daclatasvir plus standard care, or a control arm receiving standard care alone. […] The primary endpoint was clinical recovery within 14 days of treatment. […] Between 26 March and 26 April 2020, 66 patients were recruited and allocated to either the treatment arm (n = 33) or the control arm (n = 33). […] Clinical recovery within 14 days was achieved by 29/33 (88%) in the treatment arm and 22/33 (67%) in the control arm (P = 0.076). […] The treatment arm had a significantly shorter median duration of hospitalization [6 days (IQR 4-8)] than the control group [8 days (IQR 5-13)]; P = 0.029. […] Cumulative incidence of hospital discharge was significantly higher in the treatment arm versus the control (Gray’s P = 0.041). […] Three patients died in the treatment arm and five in the control arm. […] Although fewer deaths were observed in the treatment arm, this was not statistically significant. | 2020-08-20 |
| 32812049 | Patients in the intensive care units (ICU) had significantly higher CEC counts than non-ICU patients and the extent of endothelial injury was correlated with putative markers of disease severity and inflammatory cytokines. | 2020-08-20 |
| 32812051 | All participants also received the recommended national standard treatment which, at that time, was lopinavir/ritonavir and single-dose hydroxychloroquine. […] The primary endpoint was time from starting the medication until discharge from hospital with secondary endpoints of duration of ICU stay and mortality. | 2020-08-20 |
| 32812187 | A recent survey has shown that the COVID-19 pandemic has culminated in dramatical and critical treatment particularly in acute infected patients. […] Pubmed, Embase, Scopus, Cochrane, and Scholar databases were searched from inception to July 1, 2020, to identify studies reporting the current treatment process and medications (e.g. hydroxychloroquine, antiviral therapy, convalescent plasma, and immunomodulatory agents) for COVID-19. […] The standard treatment refers to the published guidelines and specialist experience which varies in different articles, and the proposed treatment refers to the kind of interest suggested in the included studies. […] Moreover, Antivirals (RR 1.13, 95% CI 1.01-1.26; I2 = 47.0%) and convalescent plasma therapy (RR 1.41, 95% CI 1.01-1.98; I2 = 66.6%) had significant beneficial effects on clinical improvement. […] Especially, immunomodulators and plasma therapy showed favorable outcomes. […] An evaluation on the efficacy of proposed treatment against COVID-19. | 2020-08-20 |
| 32812713 | Our triage method was successful in separating COVID-19 positive from negative patients and maintained the regular hospital clean of COVID-19 allowing treatment continuation of regular non-COVID-19 patients. | 2020-08-20 |
| 32812715 | Mean duration of treatment until decision and referral indications did not differ between 2020 and 2019 (207 vs. 220 minutes, P = 0.26; urgent referrals 58.8% vs. | 2020-08-20 |
| 32812834 | We tracked all patients with confirmed coronavirus-19 (COVID-19) infection admitted to intensive care units (ICU) at Montefiore Medical Center (Bronx, NY). […] Acute kidney injury (AKI) was present on admission in 40.7% of patients, and developed subsequently in 36.0%; 50.9% of patients with AKI received renal replacement therapy (RRT). | 2020-08-20 |
| 32813065 | Therefore, repurposing the use of natural compounds can provide alternatives and can support therapy against COVID-19. | 2020-08-20 |
| 32813110 | Therefore, utilizing remote care in the daily workflow would be a valuable tool for the diagnosis and treatment of acute and chronic ocular conditions in this challenging clinical setting. […] We present them as well as potential diagnostic and treatment applications in view of the recent SARS-CoV-2 virus outbreak. | 2020-08-20 |
| 32813220 | The chronic comorbid conditions were identified as dominating risk factors, which should be considered in an emergency disease management and treatment choices. | 2020-08-20 |
| 32813238 | Human ACE2 expression level and pattern in various tissues might be decisive for the vulnerability, symptoms, and treatment outcomes of the SARS-CoV-2 infection. | 2020-08-20 |
| 32813283 | Several randomized clinical trials (RCTs) that investigated the effectiveness of remdesivir for the treatment of coronavirus disease-2019 (COVID-19) have generated inconsistent evidence. | 2020-08-20 |
| 32813683 | Furthermore, the temporal association of initiating treatment affects prognosis. […] He received first-line anti-TB and treatment for COVID-19 pneumonia based on local guidelines. | 2020-08-20 |
| 32813760 | Regarding clinical treatment, the most often used medicines were intravenous antibiotics (84.7%), chloroquine (45.8%) and oseltamivir (31.9%). | 2020-08-20 |
| 32813843 | We were unable to find any review of the literature or analysis on ongoing registered clinical trials that reported diagnostic tests, therapeutics, vaccines and devices for COVID-19 along with estimated enrollment, participants’ ages, study type, start and completion date, status, treatment/intervention and country. […] They were mostly on drugs and treatment, while a minority were on diagnostic tests. […] The trials identified were categorized into five classes: a) diagnostic tests; b) therapeutics; c) biologics and vaccines; d) devices and products; and e) others. […] The trials identified have potential against COVID-19 that can be applied in treatment processes after the necessary investigations and experiments. | 2020-08-20 |
| 32814095 | It is therefore imperative to monitor the QT interval during treatment; however, conventional approaches to such monitoring increase the transmission risk for the staff and strain the health system. | 2020-08-20 |
| 32814539 | In the absence of evidence based proven prophylactic or therapeutic options, chloroquine/hydroxychloroquine (CQ/HCQ) patened as first line choice in COVID-19 treatment, which raised concerns about drug poisoning especially ocular toxicity. […] This study recommended ophthalmic evaluation before CQ/HCQ prescription for treatment or prophylaxis of COVID-19 only in preexisting maculopathy. | 2020-08-21 |
| 32814634 | Seriously ill patients should be recognized quickly and early, in order to provide them with the appropriate treatment as soon as possible. | 2020-08-21 |
| 32814635 | Group B had significantly higher rates of thrombotic complications and required more admissions in intensive care units. | 2020-08-21 |
| 32814701 | If an accurate serological test is available it can be used for seroepidemiological studies and epidemic investigation in special context, but given the current situation, it may not be possible to be used for screening the normal population and in care and treatment. | 2020-08-21 |
| 32815060 | A trend towards association between absence of in-hospital treatment-dose anticoagulation on index admission and return to hospital was also observed (20.9% vs 30.9%, Padjusted = 0.06). […] Patients who returned more likely had COPD and hypertension, shorter LOS on index-hospitalization, and lower rates of in-hospital treatment-dose anticoagulation. | 2020-08-21 |
| 32815099 | This commentary throws light two scientific papers although with divergent facts converging at a point by suggesting a promising treatment option for CoVID-19 (Fang et al. | 2020-08-21 |
| 32815148 | These risks include close practitioner to patient proximity, the treatment of higher viral load areas such as the face, the potential for infective bioparticles being carried by generated plumes and aerosols, and the direct contact between device, practitioner and patient. […] The adherence to a high standard of skin preparation and asepsis, device disinfection, laser and electrosurgical plume and aerosol management and appropriate PPE should help mitigate or reduce some of the inherent treatment risks. […] COVID-19 needs to be considered in the clinic set-up along with the planning, treatment and post-treatment care of patients utilising EBD procedures. […] Some of these treatment precautions are COVID-19 specific; however, most represent adherence to good infectious disease and established laser and EBD safety precautions. | 2020-08-21 |
| 32815174 | For ICU practitioners, management of acute respiratory failure, hemodynamics, and cardiovascular complications certainly are the key for the best treatment of these patients but to date specific data on supportive ICU care for these patients are lacking, and current recommendations are based on existing evidence from other viral infections and general intensive care management. | 2020-08-21 |
| 32815238 | We present a novel case series of three kidney transplant recipients with COVID-19 who recovered after receiving COVID-19 convalescent plasma (CCP) therapy. […] Physicians should be aware of this potentially useful treatment option. | 2020-08-21 |
| 32815293 | A total of 74 ED patients in treatment before the COVID-19 outbreak, contributed to this study. […] Baseline pre-treatment evaluation included the SCL-90R, TCI-R, EDI-2 and Y-FAS 2.0 questionnaires for general psychopathology, personality and ED severity indexes. | 2020-08-21 |
| 32815342 | Robust serological assays for SARS-CoV-2 are essential for determining prior infection and the suitability of donated convalescent plasma for plasma therapy. | 2020-08-21 |
| 32815344 | The patients were categorised in three groups on the basis of the treatment they received for respiratory failure (oxygen alone, supplemental non-invasive ventilation (NIV), and intubation/ventilator) and described using descriptive statistics. […] Eleven patients received ventilator treatment, seven oxygen by mask, and four supplemental NIV. | 2020-08-21 |
| 32815354 | A total of 49 patients (67 %) had hypoxaemia and required oxygen therapy for an average of 10.1 days. […] The majority of the patients hospitalised with COVID-19 needed prolonged oxygen therapy, and there was a high incidence of severe complications. | 2020-08-21 |
| 32815416 | Mortality from COVID-19 is high among hospitalized patients and effective therapeutics are lacking. […] The trial uses response-adaptive randomization to maximize the probability that patients will receive the more beneficial treatment approach, as treatment effect information accumulates within the trial. […] By leveraging a common data safety monitoring board and pooling data with a second similar international Bayesian adaptive trial (REMAP-COVID anticoagulation domain), treatment efficacy and safety will be evaluated as efficiently as possible. […] Using an adaptive trial design, the Anti-Thrombotic Therapy To Ameliorate Complications of COVID-19 trial will establish whether therapeutic anticoagulation can reduce mortality and/or avoid the need for mechanical ventilation in patients hospitalized with COVID-19. | 2020-08-21 |
| 32815513 | Our findings suggest that even in cases of triple infection, clinical management together with respiratory therapy contributes to patient survival. | 2020-08-21 |
| 32815515 | Nonadherence to antiretroviral treatment may have been a factor in the clinical worsening of the patients. | 2020-08-21 |
| 32815593 | Currently, no effective treatment option is available for COVID-19 patients. […] Hyperactivation of the ARAS loop may be the underlying pathophysiological mechanism in COVID-19, and beta-adrenergic blockers are proposed as a potential treatment option. | 2020-08-21 |
| 32815633 | It is hoped that till the time new evidence based data is generated these communications may help spread awareness to help setup clinical protocols for other tertiary care settings. | 2020-08-21 |
| 32815742 | Moreover, not all mental health issues and treatment forms are equally amenable to online interaction. […] In contrast, in many instances, practitioners were positive about the effectiveness of treatment, and reported flexibility, a lower threshold for contact, and lack of travel time as advantages. | 2020-08-21 |
| 32815769 | Serological assays are essential for community screening, assessing infection prevalence, aiding identification of infected patients, and enacting appropriate treatment and quarantine protocols in the battle against this rapidly expanding pandemic. | 2020-08-21 |
| 32815796 | Many antiviral drugs have been repurposed for treatment but implicated minimal recovery, which further advanced the need for clearer insights and innovation to derive effective therapeutics. […] Hence, we have theoretically examined the combinatorial drug therapy by culminating the existing experimental results with in silico analyses. […] The designed combinatorial therapy paves way for further prioritized in vitro and in vivo investigations for drug with robust binding against Mpro of SARS-CoV-2. | 2020-08-21 |
| 32815845 |
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2020-08-21 |
| 32816020 | Sixteen patients had reduced staging investigations, 4 had potential changes to their treatment only, and 10 had a deviation from both investigation and potential treatment. […] Only one patient had palliation rather than potentially curative treatment. […] Care must be taken not to compromise cancer treatment and outcomes during the COVID-19 pandemic. | 2020-08-21 |
| 32816059 | Compassionate treatment with a single 1‑Gy dose to the bilateral whole-lung volume was administered, with gradual daily improvement of ventilatory function and decrease in serum inflammatory markers and oxygen support needs, including intubation. […] No treatment-related toxicity developed. […] Procedures of transport, disinfection, and treatment planning and delivery are described. | 2020-08-21 |
| 32816108 | This letter summarizes recommendations from the interdisciplinary working group of renal tumors (IAGN) of the German Cancer Society for the systemic treatment of advanced/metastatic renal cell carcinoma in the context of the current SARS-CoV-2 pandemic. | 2020-08-21 |
| 32816193 | The majority of participants (99%) reported having heard of COVID-19; 23% reported no longer being able to go outside, 17% reported that they could no longer go to their regular clinic for medical care, and 3% reported that they could no longer get medication refills. | 2020-08-21 |
| 32816200 | Since there is no specific treatment available for SARS-CoV2 infection, and or COVID-19, several clinical and sub-clinical studies are currently undertaken to find a gold-standard therapeutic regimen with high efficacy and low side effect. […] The review is intended to help readers aware of potentially effective COVID-19 treatment and provide useful references for future studies. | 2020-08-21 |
| 32816244 | Future studies should explore the impact of iron metabolism and anemia in the pathophysiology, prognosis, and treatment of COVID-19. | 2020-08-21 |
| 32816387 | Health care workers (HCWs) on frontline directly participated in the diagnosis, treatment, and care of COVID-19 patients are at high risk of getting infected with the highly infectious severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the novel coronavirus that causes COVID-19. | 2020-08-21 |
| 32816392 | Identifying at-risk groups based on immunoinflammatory signatures is valuable in directing personalised care and developing potential targets for precision therapy. | 2020-08-21 |
| 32816437 | Treatment After few days of hospitalization and supportive treatment, the patient improved clinically and was discharged. | 2020-08-21 |
| 32816503 | Psychologists working in outpatient treatment facilities reported over a 26-fold increase in telepsychology use during the pandemic, while those in Veterans Affairs medical centers only reported a sevenfold increase. | 2020-08-21 |
| 32816541 | It also speaks to social justice issues that have plagued historically marginalized communities in the United States.Responses to the pandemic must be bound by legal standards, principles of distributive justice, and societal norms of protecting vulnerable populations-core commitments of public health-to ensure that inequities are not exacerbated, and should provide a pathway for improvements to ensure equitable access and treatment in the future. | 2020-08-21 |
| 32816615 | Sumac is an herbal product, commonly consumed as a spice and was used for medical treatment for centuries. […] Recently, several scientific studies described the pathophysiology, clinical course, and the treatment of COVID-19 infection. […] The examination of the characteristics of COVID-19 infection revealed via the clinical studies suggests that Sumac extract could be useful in the treatment of COVID-19. | 2020-08-21 |
| 32816628 | Specifically, we focus on the most concerning healthcare needs for the sex workers including HIV prevention, care and treatment and sexual and reproductive healthcare. | 2020-08-21 |
| 32816693 | At our nonepicenter hospital, antibiotic days of therapy (DOT) and bed days of care (BDOC) were reduced by 151.5/month and 285/month, respectively, for March to June 2020 compared to 2018-2019 (P = 0.001 and P < 0.001). | 2020-08-21 |
| 32816835 | The COVID-19 pandemic with its severe respiratory disease has caused overflow to hospitals and intensive care units. […] After pericardial drainage and supportive care, she improved significantly within 1 week without targeted therapy. | 2020-08-21 |
| 32816844 | Several retrospective studies have examined whether patients with cancer who develop COVID-19 may be at risk of more severe viral disease if their therapy includes immune checkpoint inhibition. […] Although the data are not uniform, for now, halting or modifying cancer treatment decisions is unnecessary; meanwhile, vigilance with testing for COVID-19 in this population is recommended. | 2020-08-21 |
| 32816941 | During patient’s rehabilitation course, therapy was focused on improving activity tolerance. | 2020-08-21 |
| 32817312 | Risk stratification is crucial to optimise treatment strategies in patients with COVID-19. | 2020-08-21 |
| 32817375 | These results led several countries to approve the use of these drugs for the treatment of patients with COVID-19. […] Despite having reasonable safety profiles in the treatment of malaria and certain autoimmune conditions, both drugs are known to have potential cardiotoxic side effects. | 2020-08-21 |
| 32817399 | After adjusting for confounding factors, each additional patient per nurse increased odds of nurses and per cent of patients giving unfavourable reports; ORs ranged from 1.15 to 1.52 for nurses on medical-surgical units and from 1.32 to 3.63 for nurses on intensive care units. | 2020-08-21 |
| 32817689 | To identify investigated interventions for COVID-19 prevention or treatment via trial registry entries on planned or ongoing randomised clinical trials. […] We included relevant trial registry entries for randomized clinical trials investigating medical preventive, adjunct or supportive therapies and therapeutics for treatment of COVID-19. […] An extraordinary number of randomized clinical trials investigating COVID-19 management have been initiated with a multitude of medical preventive, adjunctive and treatment modalities. […] Blinding will be used in only 47% of trials, which may have influence on future reported treatment effects. | 2020-08-21 |
| 32817707 | Treatment targeting this immune response might be beneficial but there is limited evidence on its efficacy. […] The aim of this study was to determine if early treatment of patients with COVID-19 pneumonia with tocilizumab and/or steroids was associated with better outcome. […] This observational single-center study included patients with COVID-19 pneumonia who were not intubated and received either standard of care (SOC, controls) or SOC plus early (within 3 days from hospital admission) anti-inflammatory treatment. […] Anti-inflammatory treatment consisted of either tocilizumab (8mg/kg intravenously or 162mg subcutaneously) or methylprednisolone 1 mg/kg for 5 days or both. […] Among them, 130 received early anti-inflammatory treatment with: tocilizumab (n = 29, 22.3%), methylprednisolone (n = 45, 34.6%), or both (n = 56, 43.1%). […] Early adjunctive treatment with tocilizumab, methylprednisolone or both may improve outcomes in non-intubated patients with COVID-19 pneumonia. | 2020-08-21 |
| 32817769 | However, in the emergency setting CXR can be a useful diagnostic tool for monitoring the rapid progression of lung involvement in COVID-19, especially in patients admitted to intensive care units. […] The rapid course of SARS-CoV-2 infection and the severity and progression of lung aberrations require a method of radiological evaluation to implement and manage the appropriate treatment for infected patients. | 2020-08-21 |
| 32817820 | Traditional Chinese medicine (TCM) has been widely used in the treatment of coronavirus disease 2019 (COVID-19). […] Tongue features should be referred for diagnosis and treatment of diseases in TCM. | 2020-08-21 |
| 32818075 | Our data might provide a theoretical basis for screening the SARS-CoV-2 susceptible population and for the clinical classification of treatment of patients with COVID-19. | 2020-08-21 |
| 32818132 | The rapid community-spread of novel human coronavirus 2019 (nCOVID19 or SARS-Cov2) and morbidity statistics has put forth an unprecedented urge for rapid diagnostics for quick and sensitive detection followed by contact tracing and containment strategies, especially when no vaccine or therapeutics are known. | 2020-08-21 |
| 32818151 | It is also used uncommonly as treatment for adenoviral conjunctivitis, yet the virucidal benefits of PVI have not been clearly documented in existing clinical management guidelines for ocular surface conditions. | 2020-08-21 |
| 32818434 | We review the epidemiology, causes, clinical features, and current treatment protocols for multisystem inflammatory syndrome in children and adolescents associated with COVID-19. […] These insights provide evidence for the need to develop a clear case definition and treatment protocol for this new condition and also shed light on future therapeutic interventions and the potential for vaccine development. | 2020-08-21 |
| 32818564 | Most respondents in practice (99%) would take measures to screen patients before treatment including paid screening measures. […] More than 93% of the respondents reported having taken special measures for routine endodontic treatment at this stage, with the most common measure taken being wearing an N95 mask. | 2020-08-21 |
| 32818650 | There is already some evidence showing large social disparities in the prevention, treatment, prognosis and/or long-term consequences of COVID-19. | 2020-08-21 |
| 32818674 | Overall, 44% of children stopped physical activities; 76% were educated at home; 22% maintained medical follow-up, and 48% and 27% continued physiotherapy and occupational therapy respectively. […] For more than 60% of children, parents performed the therapy. | 2020-08-21 |
| 32818962 | We also show how to combine the evidence of treatment effects on the occurrences of various clinical events. | 2020-08-21 |
| 32819226 | Currently, there areno effective preventive or treatment strategies for COVID-19 and has been declared as a global health emergency by WHO. | 2020-08-22 |
| 32819292 | All of the participants underwent three sessions of resin-directed hemoperfusion using continuous renal replacement therapy with a mode of continuous venovenous hemofiltration (CVVH). | 2020-08-22 |
| 32819364 | The Coronavirus Disease 2019 (COVID-19) containment measures adopted by the SA government through the lockdown of the nation have tremendously deepened the unequal treatment of asylum-seekers and refugees in SA. | 2020-08-22 |
| 32819712 | Such times warrant resource prioritization and to continue treatment with best available evidence, thereby reducing the risk of COVID-2019 transmission in times where the workforce is reduced. | 2020-08-22 |
| 32819897 | Its inclusion in a standardized regional stroke imaging protocol has enabled efficient use of hospital resources with minimal compromise or delay to the overall patient treatment schedule. | 2020-08-22 |
| 32819917 | Pre-COVID, stakeholders described various preventive, diagnostic and treatment services, including well-used antenatal and immunisation programmes and some screening for hypertension, tuberculosis, HIV and vectorborne disease. […] In all sites, pharmacists and patent medicine vendors were key providers of treatment and advice for minor illnesses. | 2020-08-22 |
| 32819964 | The provision of acute medical care to LTC residents at their facility would probably require rapid access to outpatient diagnostic imaging, within-facility access to laboratory services and intravenous medication and virtual consultations with physicians. | 2020-08-22 |
| 32820005 | The present data should shed light on the development of therapeutics for COVID-19, and optimization of GRL-0920 based on the present data is essential to develop more-potent anti-SARS-CoV-2 compounds for treating COVID-19. | 2020-08-22 |
| 32820018 | Would compulsory treatment or vaccination for COVID-19 be justified? […] However, we offer a conditional ethical argument in favour of allowing compulsory treatment and vaccination, drawing on an ethical comparison with external constraints-such as quarantine, isolation and ‘lockdown’-that have already been authorised to control the pandemic in this jurisdiction. | 2020-08-22 |
| 32820084 | Furthermore, based on the available evidence and based on the knowledge of drug interaction, we propose a quick and simple algorithm that might help both cardiologists and non-cardiologists in the management of the arrhythmic risk before and during the treatment with the specific drugs used against SARS-CoV2. | 2020-08-22 |
| 32820143 | BACKGROUND When treating patients with comorbidities who are infected with severe acute respiratory syndrome as a result of SARS-CoV-2, it is crucial to offer multidisciplinary treatment that takes into consideration all of the health conditions with which they have been diagnosed. […] He most likely was receiving cortisone therapy and had chronic pain with spondylosis with radiculopathy, bilateral gonarthrosis following total knee replacement, malaise, and fatigue. […] The knowledge gained can then be made available to the interdisciplinary treatment team to be incorporated into the treatment plan. | 2020-08-22 |
| 32820359 | This also applies to the delivery of inpatient and day-care interdisciplinary multimodal pain therapy (IMPT). […] The survey recorded the level of disruption caused by the different protective measures in the various treatment modules. […] An evaluation of the questionnaires, which were completed by two patient groups and all therapists involved, revealed that interdisciplinary multimodal pain therapy is possible without significant impairments even under the required protective measures. […] However, options like the use of protective visors or relocating treatment modules to the outdoors offer practicable alternative solutions for protection. | 2020-08-22 |
| 32820598 | To speed up this process, negative pressure wound therapy (NPWT), platelet-rich plasma (PRP), and other advanced moist wound dressing have been proposed. […] The association between adequate revascularisation, systemic anti-inflammatory, and antibiotic therapy with the multistage advanced medications ensures healing of ulcers, limb salvage, and improvement of patient prognosis. | 2020-08-22 |
| 32820746 | Additional changes include updated discussion of contraindications and precautions to influenza vaccination and the accompanying Table, updated discussion concerning use of LAIV4 in the setting of influenza antiviral medication use, and updated recommendations concerning vaccination of persons with egg allergy who receive either cell culture-based IIV4 (ccIIV4) or RIV4. | 2020-08-22 |
| 32820807 | We determined prevalence and predictors of empiric antibacterial therapy and community-onset bacterial co-infections in hospitalized patients with COVID-19. […] Data were collected on early (prescribed within 2 days of hospitalization) empiric antibacterial therapy and community-onset bacterial co-infections (positive culture or diagnostic test within 3 days). […] Of 1705 patients with COVID-19, 56.6% were prescribed early empiric antibacterial therapy; 3.5% (59/1705) had a confirmed community-onset bacterial infection. […] Patients were more likely to receive early empiric antibacterial therapy if they were older (adjusted rate ratio [ARR]: 1.04 [1.00-1.08] per 10 years), had a lower body mass index (ARR: 0.99 [0.99-1.00] per kg/m 2), had more severe illness (e.g., severe sepsis, ARR: 1.16 [1.07-1.27]), had a lobar infiltrate (ARR: 1.21 [1.04-1.42]), or were admitted to a for-profit hospital (ARR: 1.30 [1.15-1.47]). […] Despite this, half of patients received early empiric antibacterial therapy. | 2020-08-22 |
| 32820868 | Therefore, there is a significant unmet medical need for a safe and effective treatment for COVID-19. […] Despite promising results in the preclinical and clinical applications of MSC therapy for coronavirus infections, the controversy still exists, and thus further investigation is required to understand the efficacy of these therapies. | 2020-08-22 |
| 32820986 | We implemented a program of serial visits in a hostel for confined homeless of the city council social services, for the monitoring and treatment of mental disorders and substance abuse problems. | 2020-08-22 |
| 32821027 | This initiative increased provider/patient communication and attention to staff safety, improved palliative care and patient support services, lowered PPE consumption, and streamlined clinical workflows. | 2020-08-22 |
| 32821086 | Development and manufacturing of specific therapeutics and vaccines to treat COVID-19 are time-consuming processes. […] At this time, using available conventional therapeutics along with other treatment options may be useful to fight COVID-19. […] Moreover, remdesivir may be an effective therapy in vitro and in animal models infected by SARS and MERS coronaviruses. […] In this study, characteristics of remdesivir and its usage for treatment of COVID-19 are reviewed based on an electronic search using PubMed and Google Scholar. | 2020-08-22 |
| 32821132 | To determine whether new pulmonary lesions will develop in COVID-19 patients with negative initial chest CT findings and to investigate their CT features and outcome during treatment. […] In COVID-19 patients with negative initial chest CT findings, new pulmonary lesions may develop during treatment. | 2020-08-22 |
| 32821174 | The correct answer may lead to better insight and more effective treatment. | 2020-08-22 |
| 32821441 | Our provincial simulation program in the province of Alberta, Canada (population = 4.37 million; geographic area = 661,848 km2), has rapidly responded to this need by leading the intake, design, development, planning, and co-facilitation of over 400 acute care simulations across our province in both urban and rural Emergency Departments, Intensive Care Units, Operating Rooms, Labor and Delivery Units, Urgent Care Centers, Diagnostic Imaging and In-patient Units over a 5-week period to an estimated 30,000 learners of real frontline team members. | 2020-08-22 |
| 32821607 | There is currently no FDA-approved medical treatment or vaccine for COVID-19, so a variety of drugs and medicinal therapies have been repurposed for use in hospital settings and clinical studies while the medical community waits for a medication to be approved and standardized. | 2020-08-22 |
| 32821757 | Almost all countries have been affected by COVID-19, and resultingly, various drug trials have been conducted, however, a targeted treatment remains to be made accessible to the public. | 2020-08-22 |
| 32821783 | It also ties dedicated professionals to the clinic instead of being available to emergency rooms, bedsides, and intensive care units, knowing if their clinic doors close vulnerable women may be driven to desperate acts. […] Instructions, medication prescriptions, and routine follow-up can all be safely done remotely. | 2020-08-22 |
| 32821884 | To date, no specific antiviral treatment has been confirmed. | 2020-08-22 |
| 32821885 | Because of the uninterrupted spread of novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infectious disease (COVID-19) with substantial illness and mortality rates, there is an urgent requirement of suitable antiviral agent/therapy to control this pandemic, but not yet established. […] Hence, blocking at the initial stage of virus entry could be a promising strategy/therapy to combat the SARS-CoV-2 infection. […] These finding may provide a novel antiviral therapy against COVID-19, which might control the current global health crisis. | 2020-08-22 |
| 32821909 | Virtual geriatric clinics demonstrate evidence of productivity, benefit to patients, cost effectiveness and patient satisfaction with the treatment provided. | 2020-08-22 |
| 32821939 | To determine the efficacy of 5 or 10 days of remdesivir treatment compared with standard care on clinical status on day 11 after initiation of treatment. […] Differences between remdesivir treatment groups and standard care were calculated using proportional odds models and expressed as odds ratios. […] Median length of treatment was 5 days for patients in the 5-day remdesivir group and 6 days for patients in the 10-day remdesivir group. […] Among patients with moderate COVID-19, those randomized to a 10-day course of remdesivir did not have a statistically significant difference in clinical status compared with standard care at 11 days after initiation of treatment. | 2020-08-22 |
| 32821955 | Especially the number of beds needed on isolation wards and intensive care units (ICU) are the biggest concerns. […] Of these 84 needed treatment on the ICU. | 2020-08-22 |
| 32822208 | Rationale: Aerosol generation with modes of oxygen therapy such as high-flow nasal cannula and noninvasive positive-pressure ventilation is a concern for healthcare workers during the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic. | 2020-08-22 |
| 32822220 | A large number of patients with atrial fibrillation, venous thromboembolism, or valvular heart disease are chronically anticoagulated with vitamin K antagonists and rely on frequent follow ups at anticoagulation clinics for management of their anticoagulation therapy. | 2020-08-22 |
| 32822413 | Determining the clinical, biological and radiological characteristics of patients with suspected COVID-19 infection will be key to early treatment and isolation and the tracing of contacts. | 2020-08-22 |
| 32822775 | We measured: (a)perfused boundary region (PBR) of the sublingual arterial microvessels (increased PBR indicates reduced glycocalyx thickness), (b)pulse wave velocity (PWV), (c)global LV longitudinal strain (GLS), (d)global work index (GWI) using speckle tracking echocardiography and e)C-reactive protein (CRP), malondialdehyde (MDA) and protein carbonyls (PCs) as oxidative stress markers at baseline and post-treatment. | 2020-08-22 |
| 32822917 | Henceforth, in the present article, disinfection technologies for handling COVID-waste from its separate collection to various physical and chemical treatment steps have been reviewed. | 2020-08-22 |
| 32823069 | SARS-CoV-2 was detected on swab samples taken from surfaces of food preparation and service areas, hospital isolation wards, an air exhaust duct screen, air-conditioning filter, sewage treatment unit and air sample during investigations conducted in response to COVID-19 outbreaks on a ferryboat, nursing home, isolation facility and COVID-19 hospital wards. | 2020-08-22 |
| 32823131 | This study demonstrated with appropriate sample pre-treatment, Xpert Xpress SARS-CoV-2 assay can be used to test on non-validated specimen types including DTS & LRT specimens. | 2020-08-22 |
| 32823144 | Due to the rapid onset and spread of the COVID-19 pandemic, the treatment of COVID-19 patients by hydroxychloroquine alone or in combination with other drugs has captured a great deal of attention and triggered considerable debate. | 2020-08-22 |
| 32823355 | Additionally, various arrangements were necessary to cover the needs of prevention, treatment and follow-up care as well as protection of staff. | 2020-08-22 |
| 32823363 | To manage the expected COVID-19 patient load major restrictions in in- and outpatient treatment had to be made. | 2020-08-22 |
| 32823901 | Scientist and government agencies around the globe are putting forward their best efforts and resources for the effective treatment of human coronavirus infections; however, neither vaccines nor antiviral drugs are available for the treatment of human coronaviruses (HCoV) infections such as SARS (severe acute respiratory syndrome), MERS (Middle Eastern respiratory syndrome), and COVID-19. […] Moreover, very few reports have addressed the clinical features and current status of treatment for COVID-19; we have adequately addressed these topics in detail in this review. […] Finally, a detailed account of clinical trials of vaccines and other therapeutics currently in progress has been delineated. | 2020-08-23 |
| 32823999 | Care modifications included telemedicine (74%) and postponement of appointments (34%), scans (34%) or treatment (10%). […] Worry about COVID-19 infection was moderately high (mean 5.8/10) and significantly related to higher cancer-related worry; associated with lower emotional functioning irrespective of treatment intent. […] Patients who did not know their treatment intent (22%) had significantly higher COVID-19 worry and insomnia. […] In summary, care experiences were generally positive; however, cancer-related worry, low resilient coping and uncertainty about treatment intent were associated with COVID-19 worry. | 2020-08-23 |
| 32824110 | The main contribution of this work is the evidence of contagious sentiments and, consequently, the possibility of using this new dimension of social media as a form of a “collective therapy”. | 2020-08-23 |
| 32824122 | The Inflammatory Bowel Disease (IBD) population, which may require treatment with immunosuppressive medications, may be uniquely vulnerable to COVID-19 infection. […] We present an interesting case of a Crohn’s patient inadvertently administering anti-cytokine therapy during the pre-symptomatic period of COVID-19 infection. | 2020-08-23 |
| 32824674 | Data from patients with prostate cancer treated with androgen-deprivation therapy seem to confirm this hypothesis. […] In this perspective, we discuss the available evidence on sex hormones and hormone therapy in patients infected with SARS-CoV-2, and we highlight the possible implications for cancer patients, who can receive hormonal therapies during their treatment plans. | 2020-08-23 |
| 32824985 | By examining the use of 4,4’-diaminodiphenyl sulfone (DDS) in the treatment of patients with Hansen’s disease, also diagnosed as Alzheimer’s disease, this study demonstrates the diverse mechanisms involved in the activation of inflammasomes. | 2020-08-23 |
| 32825063 | The lack of effective treatment strategy and vaccines against the SARS-CoV-2 poses a threat to human health. | 2020-08-23 |
| 32825283 | Many scientists have tried their best to discover safe and effective drugs for the treatment of this disease; however, there are still no approved standard therapeutics or effective antiviral drugs on the market. […] Fortunately, some novel antiviral strategies, such as convalescent plasma, clustered regularly interspaced short palindromic repeats (CRISPR), and mesenchymal stem cell (MSC) therapy, potentially offer an additional or alternative option or compassionate use for the people suffering from COVID-19, especially for critically ill patients, although their safety and efficacy are also under study. […] In this review, we explore the applications, possible mechanisms, and efficacy in successful cases using convalescent plasma, CRISPR, and MSC therapy for COVID-19 treatment, respectively. | 2020-08-23 |
| 32825295 | Background: The incidence and prognosis of SARS-CoV-2-positive cancer patients on active oncologic treatment remain unknown. […] Materials & Methods: In this study, we analysed all consecutive cancer patients with solid tumours undergoing active intravenous treatment (chemotherapy, immunotherapy, targeted therapy, alone or in combination) between 21 February and 30 April 2020, in a high-volume cancer centre in Lombardy, Italy. […] Results: We registered 17 SARS-CoV-2-positive patients among 1267 cancer patients on active treatment, resulting in an incidence of 1.3%. […] We could not demonstrate any correlation between SARS-CoV-2 infection and tumour or treatment type. | 2020-08-23 |
| 32825438 | There is further need for comprehensive genomics and structural-functional studies to lead towards definitive conclusions regarding their criticality and that can eventually define their relevance to therapeutics development. | 2020-08-23 |
| 32825444 | FDA)-approved drugs for the treatment of COVID-19, although several antiviral drugs are available for repurposing. | 2020-08-23 |
| 32825629 | The study population consisted of 49 COVID-19 patients, including 16 (32.6%) with severe illness, 12 (24.5%) with severe acute kidney injury (AKI), and 8 (16.3%) requiring renal replacement therapy (RRT). | 2020-08-23 |
| 32825737 | In this regard, nanoparticles can be used as antiviral agents for the treatment of various viral infections. | 2020-08-23 |
| 32825816 | New emerging infections have no known treatment. […] Assessing potential drugs for safety and efficacy enables clinicians to make evidence-based treatment decisions and contributes to overall outbreak control. […] We searched PubMed for all clinical data (including clinical trial, observational and case series) describing treatment for patients with influenza A(H1N1)pdm09 and ClinicalTrials.gov for research that aimed to enrol patients with the disease. […] Thirty-three thousand eight hundred sixty-nine treatment courses for patients hospitalised with A(H1N1)pdm09 were detailed in 160 publications. […] Five hundred ninety-two patients received treatment (or placebo) as participants in a registered interventional clinical trial with results publicly available. […] The result was a reliance on use under compassionate circumstances, resulting in continued uncertainty regarding the potential benefits and harms of anti-viral treatment. | 2020-08-23 |
| 32825892 | After critical panel discussion, all the attending doctors came to a conclusion that Ivermectin can be a potential molecule for prophylaxis and treatment of people infected with Coronavirus, owing to its anti-viral properties coupled with effective cost, availability and good tolerability and safety. | 2020-08-23 |
| 32826119 | This should be considered in the treatment and maintenance of their voice and professional career at current and future stressful times. | 2020-08-23 |
| 32826326 | The leading causes of AKI included septic shock (25 of 41, 61.0%), volume insufficiency (eight of 41, 19.5%), and adverse drug effects (five of 41, 12.2%). | 2020-08-23 |
| 32826331 | Cytokine release syndrome (CRS) is a life-threatening complication induced by systemic inflammatory responses to infections, including bacteria and chimeric antigen receptor T cell therapy. […] Tocilizumab treatment decreased the PAI-1 levels and alleviated critical illness in severe COVID-19 patients. | 2020-08-23 |
| 32826388 | Here we highlight a mechanism by which the IL6-hypoxia curse causes a deadly hypercoagulable state in COVID-19 patients, and we suggest a path to therapy. | 2020-08-23 |
| 32826432 | However, the clinical effectiveness of early high-flow nasal oxygen treatment in patients with coronavirus disease 2019 with acute hypoxemic respiratory failure has not been explored. […] This study aimed to analyze the effectiveness of high-flow nasal oxygen treatment and to identify the variables predicting high-flow nasal oxygen treatment failure in coronavirus disease 2019 patients with acute hypoxemic respiratory failure. […] High-flow nasal oxygen failure was more likely in patients who were older (p = 0.030) and male (p = 0.037), had a significant increase in respiratory rate and a significant decrease in the ratio of oxygen saturation/FIO2 to respiratory rate index within 3 days of high-flow nasal oxygen treatment. | 2020-08-23 |
| 32826619 | : The COVID-19 pandemic has created an urgent need to expand access to substance use disorder (SUD) treatment through telehealth. […] A more permanent adoption of tele-SUD treatment options could positively alter the future of SUD treatment. […] These steps are: (1) investing in telehealth infrastructure to enable health care providers and patients to use telehealth; (2) training and equipping providers to provide SUD treatment through telehealth; (3) providing patients with the financial and social support, hardware, and training necessary to use telehealth; (4) making temporary changes to telehealth law and regulation permanent. […] We believe these 4 steps will be critical to initiating SUD treatment for many persons that have yet to receive it, and for preserving SUD treatment continuity for millions of other patients both during and after the pandemic. | 2020-08-23 |
| 32826620 | : Methadone regulations have changed minimally since 1974, despite advances in the understanding of the nature of opioid use disorder (OUD) and the role of medications in its treatment. […] At that time, most patients with OUD were considered to have anti-social personality disorders and the regulations aimed to exert maximal control over medication access. […] Pregnant women (and parents with children) were forced to negotiate dosing in dangerous conditions.A revised methadone system must provide treatment that is local, flexible, and limited in size to manage viral contagion risks. | 2020-08-23 |
| 32826642 | Upon follow-up on our patients, it seems that most patients are recovering with treatment, and overall, there is a low reported mortality rate. | 2020-08-23 |
| 32826719 | Within HCWs, personnel of intensive care units (ICUs) are at the forefront of treating patients with a severe course of COVID-19 infection and therefore represent an extremely vulnerable group. | 2020-08-23 |
| 32826796 | Demographic, clinical, and treatment data were extracted from the electronic patient files. | 2020-08-23 |
| 32826818 | Among the 97 patients with IMV, 28 (28.9%) received prone ventilation, 57 (58.8%) received neuromuscular blocked therapy, and 22 (11.3%) received tracheostomy due to prolonged ventilator use. | 2020-08-23 |
| 32826914 | COVID-19 caused by SARS-CoV-2 has become a global pandemic requiring the development of interventions for the prevention or treatment to curtail mortality and morbidity. | 2020-08-23 |
| 32827081 | With the COVID-19 boom, many clinical trials are being carried out using different sources with an emphasis on MSC-based therapy used to inhibit inflammation. […] One of the biggest challenges in the current treatment of COVID-19 is the cytokine storm, however MSCs can prevent or mitigate this cytokine storm through their immunomodulatory capacity. […] We look forward to the results of the ongoing clinical trials to find a treatment for the disease. | 2020-08-23 |
| 32827292 | Currently, the most effective treatment against obesity available is bariatric and metabolic surgery (BMS), which further resolves or improves other independent risk factors like diabetes and hypertension. | 2020-08-23 |
| 32827313 | Due to the absence of precise treatment, the investigators are discovering other effective, protective, and healing choices. | 2020-08-23 |
| 32827400 | The current review intended to examine the current status of drugs being repurposed for COVID-19 treatment. […] The search terms used included repositioning of drugs, repurposing of drugs and COVID-19 therapy, and SARS-CoV-2 therapy. […] Repurposing of drugs from different pharmacological groups including antivirals like remdesivir, lopinavir, ritonavir, arbidol, oseltamivir, penciclovir, favipiravir, ganciclovir, and ribavirin; other antibiotics like azithromycin, ivermectin, eravacycline, valrubicin, streptomycin, nitazoxanide, teicoplanin, caspofungin, and colistin; and other agents like hydroxychloroquine, chloroquine, tocilizumab, camostat, nafamostat, carfilzomib, interferon, aprepitant, and dexamethasone can be considered for COVID-19 therapy. […] With continuous research and technical advancements, repurposing will no doubt provide a notable scientific contribution to innovation in drug development and pharmacotherapy practice for the treatment of new diseases or existing diseases in a new way. | 2020-08-23 |
| 32827582 | Moreover, because the signs and symptoms of COVID-19 are easily misattributed to the sequelae of cancer itself, such as pulmonary embolism, or its treatment, such as nausea and diarrhea, diagnosis may be delayed or missed. […] This review summarizes the current understanding of the transmission, clinical presentation, diagnosis and differential diagnosis, pathogenesis, rationale to treat the cancer or not, treatment and prevention of COVID-19 with an emphasis on implications in cancer. | 2020-08-23 |
| 32827587 | Several questions on the DNACPR/TEAL forms were answered significantly differently with increases in patients being identified as suitable for CPR (23.8% versus 9.05%; p < 0.001) and full active treatment (30.5% versus 26.1%; p = 0.028). […] During the COVID-19 pandemic, the emphasis on senior decision making and conversations around ceilings of treatment appears to have changed practice, with a higher proportion of patients having DNACPR/TEAL status documented. […] Understanding patient preferences around life-sustaining treatment versus comfort care is part of holistic practice and supports shared decision making. | 2020-08-23 |
| 32827705 | Thus, diagnosing gastrointestinal symptoms that precede respiratory problems during COVID-19 may be necessary for improved early detection and treatment. | 2020-08-23 |
| 32827987 | The combination of Hydroxychloroquine (HCQ) and azithromycin showed effectiveness as a treatment for COVID-19 and is being used widely all around the world. […] On-treatment ECGs were repeated 3-6 h after the second HCQ loading dose and 48-72 h after the first dose of the combination. […] Baseline and on-treatment ECG findings were compared. | 2020-08-23 |
| 32828120 | With increase in number of cases and mortality from Covid, the primary focus is shifted to the management of the Covid crisis and other health emergencies thus affecting normal health services and routine treatment of other diseases like cancer. […] This article reviews the published literature and guidelines on Covid and cancer and discusses them to optimize the care of cancer patients during Covid pandemic to improve treatment outcomes. […] The Covid 2019 pandemic places cancer patients in a very difficult situation wherein if they seek treatment, they are exposing themselves to a risk of developing CoV2 infection and if they do not, the probability of dying without treatment increases. […] Hence, for them it is a choice between the devil and deep sea, and it is for the healthcare providers to triage patients and treat who cannot wait even though the data from the carefully selected cohort of patients show no increase in mortality or morbidity from treatment during Covid. | 2020-08-24 |
| 32828135 | The COVID-19 pandemic is showing an exponential growth, mandating an urgent need to develop an effective treatment. […] Indeed, to date, a well-established therapy is still lacking. […] Univariate logistic regression analysis showed that HCQ treatment was not significantly associated with decreased mortality in COVID-19 patients. | 2020-08-24 |
| 32828137 | As the global COVID-19 pandemic continues, unabated and clinical trials demonstrate limited effective pharmaceutical interventions, there is a pressing need to accelerate treatment evaluations. […] Second, if an individual component of a combination offers a therapeutic effect, then in the absence of antagonism, a trial of combination therapy should still detect individual efficacy. […] Finally, given the severity of the current pandemic and the absence of treatment options, the likelihood of detecting a treatment effect with combination therapy maintains scientific enthusiasm for evaluating repurposed treatments. | 2020-08-24 |
| 32828189 | These disparities are noted in epidemiology, pathophysiology, clinical manifestations, disease progression, and response to treatment. […] We aim to guide clinicians and researchers to consider sex and gender in their approach to diagnosis, prevention, and treatment of diseases as a necessary and fundamental step towards precision medicine, which will benefit men’s and women’s health. | 2020-08-24 |
| 32828312 | Here, we constructed a COVID-19 protein microarray of potential therapy targets, which contains the main drug targets to the SARS-CoV-2 virus and the anti-virus, anti-inflammatory cellar targets of the host. | 2020-08-24 |
| 32828489 | In this article, we provide an update on epigenetic-sensitive mechanisms and repurposed drugs interfering with epigenetic pathways which may be clinically suitable for risk stratification and beneficial for treatment of patients affected by severe viral respiratory infections. | 2020-08-24 |
| 32828569 | Unique examination findings and responses to treatment have been identified. […] In this article, we seek to provide pharmacologic and treatment recommendations specific to delirium in patients with COVID-19. […] No data are currently available on the treatment of delirium in patients with COVID-19. […] Extrapolating from general delirium treatment, Middle Eastern respiratory syndrome/severe acute respiratory syndrome case reports, and our experience, preliminary recommendations for pharmacologic management have been assembled. […] Further research into the pathophysiology of COVID-19 will be key in developing more targeted treatment guidelines. | 2020-08-24 |
| 32828595 | Given the high infectivity rate as well as multisystem presentation, it is important to continue to report on novel presentations of the virus for early identification and treatment of complications. | 2020-08-24 |
| 32828609 | Orthodontists were more concerned with the financial impact of the pandemic than with the orthodontic treatment itself. | 2020-08-24 |
| 32828614 | ST-segment elevation myocardial infarction (STEMI) is a fatal cardiovascular emergency requiring rapid reperfusion treatment. […] During the coronavirus disease-2019 (COVID-19) pandemic, medical professionals need to strike a balance between providing timely treatment for STEMI patients and implementing infection control procedures to prevent nosocomial spread of COVID-19 among health care workers and other vulnerable cardiovascular patients. […] This study evaluates the impact of the COVID-19 outbreak and China Chest Pain Center’s modified STEMI protocol on the treatment and prognosis of STEMI patients in China. […] Based on the data of 28,189 STEMI patients admitted to 1,372 Chest Pain Centers in China between December 27, 2019 and February 20, 2020, the study analyzed how the COVID-19 outbreak and China Chest Pain Center’s modified STEMI protocol influenced the number of admitted STEMI cases, reperfusion strategy, key treatment time points, and in-hospital mortality and heart failure for STEMI patients. […] With an average delay of approximately 20 min for reperfusion therapy, the rate of in-hospital mortality and in-hospital heart failure increased during the outbreak, but the rate of in-hospital hemorrhage remained stable. […] There were reductions in STEMI patients’ access to care, delays in treatment timelines, changes in reperfusion strategies, and an increase of in-hospital mortality and heart failure during the COVID-19 pandemic in China. | 2020-08-24 |
| 32828694 | Patients received antiviral therapy, steroids and intravenous immunoglobulins. | 2020-08-24 |
| 32828741 | There is no currently approved protocol for treatment. […] Four of the five patients responded well to treatment. […] MCN treatment seems to increase the survival rate of these patients. | 2020-08-24 |
| 32828864 | To investigate environmental SARS-CoV-2 contamination in the isolation rooms of severe COVID-19 patients requiring mechanical ventilation or high-flow oxygen therapy. […] Patients 1 and 2 received mechanical ventilation with a closed suction system, while patient 3 received high-flow oxygen therapy and non-invasive ventilation. | 2020-08-24 |
| 32828896 | Hydroxychloroquine/azithromycin treatment was associated with a lower ICU admission rate (P=0.008). […] This may be due to the care bundle used in our hospital (early hospitalisation, treatment with hydroxychloroquine/azithromycin and/or corticosteroids, non-invasive respiratory support, etc). | 2020-08-24 |
| 32828990 | Knowledge management tools that assist in systematic review and exploration of scientific knowledge generally are of obvious potential importance in evidence based medicine in general, but also to the design of therapeutics based on the protein subsequences and fold motifs of virus proteins as considered here. | 2020-08-24 |
| 32829051 | We explored the effect of antiretroviral treatment (ART) history on clinical characteristics of patients with SARS-CoV-2 and HIV co-infection. | 2020-08-24 |
| 32829149 | There is an urgent need for therapeutics, both through the repurposing of approved drugs and the development of new treatments. | 2020-08-24 |
| 32829256 | The worldwide infection with the new Severe Acute Respiratory Syndrome coronavirus 2 (SARS-CoV-2) demands urgently new potent treatment(s). […] This shows that thioridazine and its two photoproducts might represent new potent medicines to be used for treatment in this outbreak. […] The transition to human subjects of the suggested treatment will be smooth due to the fact that the drugs are already available on the market. | 2020-08-24 |
| 32829467 | SARS-CoV-2 was detected in multiple nasopharyngeal, blood, and pleural samples, despite antiviral and immunomodulator treatment. | 2020-08-24 |
| 32829511 | The safety of immunosuppressive treatment in patients with Immune-Mediated Inflammatory Diseases (IMIDs) during the Coronavirus pandemic is questioned and it is utmost important for public health. […] We searched studies trough MEDLINE/EMBASE database, including patient with IMID, undergoing immunosuppressive treatment with a positive diagnosis for SARS-CoV 2. | 2020-08-24 |
| 32829718 | This practitioner review aims to give an overview of the assessment and treatment of health-related worries in children and young people in the context of the COVID-19 pandemic. | 2020-08-25 |
| 32829885 | Among these, thrombotic complications have emerged as an important issue in patients with COVID-19 infection, particularly in patients in intensive care units. | 2020-08-25 |
| 32830110 | Implemented on 22 January 2020, the telemedicine technology allowed WCH providers to conduct teleconsultations, telerounds, teleradiology and tele-intensive care unit, which in culmination provided screening, triage and treatment for COVID-19 and other illnesses. | 2020-08-25 |
| 32830154 | Although some patients will become critically ill, the guidelines for respiratory failure and septic shock for non-COVID-19 cases can be followed for supportive treatment. | 2020-08-25 |
| 32830267 | Twenty-two patients (26.8%) temporarily withdrew from their IBD treatment because of COVID-19. […] Therapy for IBD, including immunomodulators and biologic therapy, is not related to a greater severity of COVID-19, and SARS-CoV-2 infections do not appear to be related to IBD flare-ups. | 2020-08-25 |
| 32830296 | Interventions are needed to ensure that PLWH have updated information and adhere to medication regimens, and to reduce the impact of COVID-19 on social isolation, economic stability, healthcare access, and other social determinants of health within this vulnerable population. | 2020-08-25 |
| 32830527 | Currently, there is no effective treatment that targets the cytokine storm and helps regenerate the damaged tissue. […] As a result, MSC therapy is a potential treatment approach for COVID-19. […] Although some current clinical trials have treated COVID-19 patients with DPSCs, this therapy has not been approved. […] Here, we review the potential use of DPSCs and their significance in the development of a therapy for COVID-19. | 2020-08-25 |
| 32830619 | Several guidelines have been developed, which recommend treatment adjustments depending on the site of cancer, grade, and stage. […] A link to a prestructured questionnaire was sent through email to 100 randomly selected cancer patients in different stages of treatment and follow-up. | 2020-08-25 |
| 32830642 | We report a case of a COVID-19 patient who developed disseminated strongyloidiasis following treatment with high-dose corticosteroids and tocilizumab. […] Screening for Strongyloides infection should be pursued in individuals with COVID-19 who originate from endemic regions before initiating immunosuppressive therapy. | 2020-08-25 |
| 32830894 | We designed a proof-of-concept randomized controlled trial to evaluate whether treatment with canakinumab prevents progressive respiratory failure and worsening cardiac dysfunction in patients with SARS-CoV2 infection, myocardial injury, and high levels of inflammation. | 2020-08-25 |
| 32830930 | We also highlight the results of in vitro and in vivo data from several studies, which have broadened our knowledge of potential drug candidates for the successful treatment of patients infected with and discuss possible virus and host-based treatment options against SARS-CoV-2. | 2020-08-25 |
| 32830949 | Although respiratory symptoms are a key feature of the disease, many people who are hospitalized with COVID-19 also suffer acute kidney injury, a condition that exacerbates patient mortality and may have to be treated through renal replacement therapy. […] However, supplies for dialysis treatment, including dialysate, have also run dangerously low in hospitals at the epicenter of the pandemic. […] A fixed-bed column loaded with Ti3C2Tx was designed to further evaluate the adsorption performance under continuous fluid-flow conditions, mirroring conditions of continuous renal replacement therapy modalities. | 2020-08-25 |
| 32831083 | The COSUP clinical team prioritised opioid substitution therapy using methadone and COVID-19 screening over generalist healthcare to manage withdrawal and contain tension and anxiety. | 2020-08-25 |
| 32831104 | These findings provide novel insight into the genetic variation in ACE2 which may affect the SARS-CoV-2 recognition and infection, and COVID-19 susceptibility and treatment. | 2020-08-25 |
| 32831151 | The patients, who are aged from 18 to 75 years old, with a confirmed or suspected diagnosis of severe or critical COVID-19, will be consecutively recruited in the study, according to the guideline on diagnosis and treatment of COVID-19 (the 7th version) issued by National Health Commission of the People’s Republic of China. | 2020-08-25 |
| 32831155 | Secondary objectives: To examine whether the effect of corticosteroids compared with usual care or placebo on mortality up to 28 days after randomization varies between subgroups related to treatment characteristics, disease severity at the time of randomization, patient characteristics, or risk of bias. | 2020-08-25 |
| 32831186 | Search engine queries for chest pain have risen during the pandemic as have related searches with alternative attribution for chest pain or home care for chest pain, suggesting that recent drops in ACS presentations may be due to patients avoiding the emergency room and potential treatment in the midst of the COVID-19 pandemic. | 2020-08-25 |
| 32831320 | A high demand for care has mainly been observed in intensive care units and critical care resources, which is why the need to redistribute resources in critical medicine emerged, with an emphasis on distributive justice, which establishes the provision of care to the largest number of people and saving the largest number of lives. | 2020-08-25 |
| 32831339 | Anticoagulant treatment has become one of the therapeutic foundations for this infection; however, its implementation in children can be difficult since, until recently, it was not considered in the pediatric population. […] After an extensive review of the published literature, a proposal was generated that offers suggestions for anticoagulant treatment, considering available resources in Mexico. | 2020-08-25 |
| 32831518 | Therefore, it is of interest to design and develop candidates for treatment, therapy and prevention. […] The spike glycoprotein of the virus known to potentially interact with angiotensin converting enzyme 2 as a cell entry receptor is a suitable candidate for further consideration as vaccine and treatment candidate. | 2020-08-25 |
| 32831521 | We highlight putative loci and modes of therapeutic intervention that may become beneficial preventive and treatment modalities for individuals at risk of SARS-CoV2 infection and CoViD-19 patients. | 2020-08-25 |
| 32831932 | Since its discovery, amphotericin B (AmB) is still one of the most common first-line choices in treatment pulmonary mycoses for over seventh decades from discovery. | 2020-08-25 |
| 32831936 | Till date, no pharmaceutical agent is known to manage in terms of prevention and treatment of coronavirus disease 2019 (COVID-19), the disease caused by a novel virus. | 2020-08-25 |
| 32831940 | Several treatments have been tested in the race to find a treatment regimen for this deadly viral infection. | 2020-08-25 |
| 32832038 | Therefore, particular care to the patients with underlying diseases is needed during the treatment of COVID-19 patients. | 2020-08-25 |
| 32832263 | Currently, there is no approved treatment or vaccine available against it. | 2020-08-25 |
| 32832425 | Across the globe, hospitals are being challenged by a large number of patients presenting to the emergency room for treatment, creating scarcities of critical care resources, and uncovering the need for formal crisis standards of care. […] Difficult life and death decisions, which may create severe moral distress to the physicians, have to be made in emergency rooms and intensive care units. | 2020-08-25 |
| 32832575 | Patients who require weeks of intravenous antibiotic therapy after hospital discharge due to severe bacterial infections, generally referred to as outpatient parenteral antibiotic therapy (OPAT), are at increased risk for contracting and/or transmitting COVID-19 due to extensive contact with the health care system. | 2020-08-25 |
| 32832591 | The management of patients infected with SARS-CoV-2 has primarily impacted emergency departments, medical teams, and intensive care units. | 2020-08-25 |
| 32832666 | The innate therapeutic functions of MSCs administered to humans are not as robust as demonstrated in preclinical studies, and in general, the translation of cell-based therapy is impaired by a myriad of steps that introduce heterogeneity. | 2020-08-25 |
| 32832721 | In the present review we summarize the existing, and daily growing, data on the impact of COVID-19 infection on patients with diabetes, their antidiabetic therapy as well as the extra precautions, apart from good glucose control, they have to take in order not to contract the virus. | 2020-08-25 |
| 32832735 | Hydroxychloroquine is one of the most commonly used drugs in COVID-19 treatment. […] In this case report, we aimed to present a young patient whose QT interval was prolonged due to hydroxychloroquine overdose which was given for COVID-19 treatment. […] O. treatment. […] The QT interval prolongation and bradycardia persisted, and the patient was hospitalized for follow-up and treatment. […] Due to the potential cardiac side effects, patients who are sent to home isolation with treatment should be educated about the use, dosage, and possible side effects of this medicine, and serial ECG monitoring should be provided to patients who are hospitalized. | 2020-08-25 |
| 32832739 | The Surviving Sepsis Campaign (SSC) Guidelines for management of severe sepsis and septic shock published in 2004 provide key elements in the treatment of sepsis that are organized into two bundles of care, the “resuscitation” and “management” bundles, including interventions to be accomplished within specified timeframes. | 2020-08-25 |
| 32832740 | We built a clinical decision support tool on the avoMD platform that systematizes and personalizes the treatment of COVID-19 by bringing point-of-care access to the guidelines specific to individual cases to the clinician’s hands. | 2020-08-25 |
| 32832877 | Both human B cell hybridoma technology and convalescent plasma therapy are promising immunological tools for therapeutic interventions. | 2020-08-25 |
| 32832913 | In the interim, anti-cytokine therapies may provide a treatment option for adults with severe coronavirus disease 2019 unresponsive to standard critical care management, including ventilation. […] This review provides an overview of the current understanding of the immunopathogenesis of coronavirus disease 2019 in adults and proposes treatment considerations for anti-cytokine therapy use in adults with severe disease. | 2020-08-25 |
| 32833200 | Here we provide a brief introduction to CoVs discussing their replication, pathogenicity, and current prevention and treatment strategies. | 2020-08-25 |
| 32833259 | Together, these data reveal marked perturbations of factor V activity in severe COVID-19, provide links to SARS-CoV-2 disease biology and clinical outcomes, and nominate a candidate biomarker to investigate for guiding anticoagulation therapy in COVID-19. | 2020-08-25 |
| 32833283 | Further aims included the identification of predictors and prognostic implications for AHF decompensation during hospital admission and the determination of a potential correlation between the withdrawal of HF guideline-directed medical therapy (GDMT) and worse outcomes during hospitalization. | 2020-08-25 |
| 32833368 | Palliative care was integrated into the process of therapeutic withdrawals in intensive care units during this crisis. […] Continuing education related to end-of-life issues and defining collaboration with palliative care is essential for intensive care teams. | 2020-08-25 |
| 32833506 | Biobanks will play a role in providing tools to examine data from those receiving treatment along with reviewing the current and long treatment outcomes associated with this novel coronavirus disease. […] Data entered into LIMS will be beneficial in designing much needed clinical trials to address any unmet needs to better address clinical treatment and outcomes. | 2020-08-25 |
| 32833568 | These patients have varying death experiences based on their location of death, the availability and utilization of various medical technologies, the amount of strain on the local health care system, the involvement of specialist palliative care (PC) teams, and access to essential medications to alleviate symptoms at the end of life. | 2020-08-25 |
| 32833598 | We are currently facing a dual challenge in therapeutics innovation with COVID-19 and loss in planetary biodiversity. […] To these ends, the existing scholarship in, and the field of precision herbal medicine provide an alternative source for discovery of novel therapeutics against the novel coronavirus. […] We propose that the application of precision herbal medicine in Africa could usefully contribute to current efforts for therapeutics innovation for the COVID-19 pandemic, and beyond. | 2020-08-25 |
| 32833671 | One-hundred(91.7%) patients required oxygen therapy, which improved percutaneous oxygen saturation (SpO2). […] Our findings suggest that oxygen plays an important role in the treatment of COVID-19 patients and that age and underlying diseases are significant risk factors for COVID-19. | 2020-08-25 |
| 32833695 | The aim of this study was to evaluate if plasma exchange, through the removal of circulating mediators, can be used as rescue therapy in these patients. | 2020-08-25 |
| 32833772 | Supportive care remains the mainstay of therapy while ongoing clinical trials are being conducted. | 2020-08-25 |
| 32833773 | The treatment of these patients remains supportive. | 2020-08-25 |
| 32833778 | As the confirmed cases of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) continue to grow with over 1 million documented infections in the United States alone, researchers and health care workers race to find effective treatment options for this potentially fatal disease. […] Mortality remains high in patients whose disease course requires mechanical ventilation and admission to intensive care units. […] While focusing on therapies to decrease mortality is essential, we must also consider the logistical hurdles faced with regard to safely and effectively delivering treatment while limiting the risk of harm to hospital staff and other noninfected patients. […] In this article, we discuss aspects of surge planning, considerations in limiting health care worker exposure, the logistics of medication delivery in a uniform and consolidated manner, protocols for delivering emergent care in a rapidly deteriorating coronavirus disease-2019 (COVID-19) patient, and safe practices for transporting infected patients. | 2020-08-25 |
| 32833780 | The pandemic forced network leaders to face an unprecedented public health crisis while navigating circumstances driven by a widely impactful disease with minimal empirical evidence regarding disease spread, containment, and treatment. | 2020-08-25 |
| 32833833 | A series of department formulates and constant improvements were made, including elective operation cancellation, altered conventional outpatient service into online outpatient service, strict control of inter department consultation prevention and entering the department, improvements in operation and treatment processes, and strict ward management. […] As a result, 1 patient with hypertensive cerebral hemorrhage and deep vein thrombosis of the right lower extremity died suddenly due to pulmonary embolism during anticoagulation treatment. […] Two patients with deep coma gave up treatment and died. | 2020-08-25 |
| 32834108 | We hope the present study should help workers in the field to develop potential vaccines and therapeutics against the novel coronavirus. | 2020-08-25 |
| 32834113 | It is recommended that telaprevir, and pyridone-containing pharmaceuticals including aminoglutethimide, apixaban, buspirone, lenalidomide, and pomalidomide be repurposed for COVID-19 treatment after suitable validation and clinical trials. | 2020-08-25 |
| 32834174 | Early detection of the disease would provide an opportunity for proactive treatment to save lives, which is the primary research objective of this study. | 2020-08-25 |
| 32834216 | I nearly miss the call as I scramble to remove my face mask while noticing it’s our water treatment plant phone. | 2020-08-25 |
| 32834241 | Many natural compounds, found mainly in plants, are associated with the treatment of various diseases. | 2020-08-25 |
| 32834259 | The COVID-19 pandemic caused by SARS-CoV-2 is a public health emergency of international concern and thus calling for the development of effective and safe therapeutics and prophylactics particularly a vaccine to protect against the infection. | 2020-08-25 |
| 32834302 | The influence of music therapy (MT) as a support intervention to reduce stress and improve wellbeing in Clinical Staff (CS) working with COVID-19 patients was evaluated. | 2020-08-25 |
| 32834374 | First, South Korea has flattened the curve of COVID-19 by combining testing, early isolation, and free treatment of positive cases combined with digital technologies without taking to “lockdown” measures. | 2020-08-25 |
| 32834376 | With the economy at a standstill, the Palestinian governing authority has limited financial resources to (re)build key sanitation, hygiene, waste treatment and water supply infrastructure. | 2020-08-25 |
| 32834406 | In terms of a short-term response, it is vital to adopt the quarantine idea of a ‘temporary cabin hospital’ and a disposal procedure of ‘circular disinfection-section repeat testing-batch transfer and quarantine-international collaborative medical treatment’. | 2020-08-25 |
| 32834485 | •Hospital wastes are being disposed of without undergoing any treatment in Tehran. | 2020-08-25 |
| 32834556 | To help make rapid decisions on treatment and isolation needs, it would be useful to determine which features presented by suspected infection cases are the best predictors of a positive diagnosis. | 2020-08-25 |
| 32834594 | The fact that no there exists yet an absolute treatment or vaccine for COVID-19, which was declared as a pandemic by the World Health Organization (WHO) in 2020, makes very important spread out over time of the epidemic in order to burden less on hospitals and prevent collapsing of the health care system. | 2020-08-25 |
| 32834599 | Since the absence of medical resources or targeted therapeutics, systemic containment policies have been prioritized but some critics query what extent can they mitigate this pandemic. | 2020-08-25 |
| 32834600 | The model can also show a backward bifurcation at R 0 = 1 whenever the treatment saturation parameter, which describes the hospital capacity, is larger than a specific threshold. […] The data pertain to infected individuals who self-isolate in their homes and visit the hospital for further treatment. | 2020-08-25 |
| 32834603 | Due to absence of specific vaccine or therapy, non-pharmacological interventions including social distancing, contact tracing are essential to end the worldwide COVID-19. | 2020-08-25 |
| 32834604 | The advantage of doing these tasks to minimize the virus spread by various mitigation, how well the mitigations are working, how many cases have been prevented by this mitigations, an idea about the number of patients that will recover from the infection with old medication, understand how much time will it take to for this pandemic to end, we will be able to understand and analyze how fast or slow the virus is spreading among regions and the infected patient to reduce the spread based clear understanding of the correlation between the spread and weather conditions. | 2020-08-25 |
| 32834607 | The goal of this paper is to reduce the size of susceptible, infected, exposed and asymptomatic groups to consequently eradicate the infection by using two actions: the quarantine and the treatment of infected people. […] Finally, the controller tuned with the estimated parameters of the Chinese data is applied to the actual data of Spain to compare the quarantine and treatment policies in both countries. | 2020-08-25 |
| 32834612 | The ongoing development in AI and ML has significantly improved treatment, medication, screening, prediction, forecasting, contact tracing, and drug/vaccine development process for the Covid-19 pandemic and reduce the human intervention in medical practice. | 2020-08-25 |
| 32834618 | Since there is no effective vaccine and treatment for this virus, therefore, the only way to mitigate this infection is the implementation of non-pharmaceutical interventions such as social-distancing, community lockdown, quarantine, hospitalization or self-isolation and contact-tracing. | 2020-08-25 |
| 32834620 | In the absence of neither an effective treatment or vaccine and with an incomplete understanding of the epidemiological cycle, Govt. has implemented a nationwide lockdown to reduce COVID-19 transmission in India. | 2020-08-25 |
| 32834623 | Particularities of SARS-CoV-2, such as its persistence in surfaces and the lack of a curative treatment or vaccine against COVID-19, have pushed authorities to apply restrictive policies to control its spreading. | 2020-08-25 |
| 32834643 | Researchers from various domains are putting their efforts to curb the spread of coronavirus via means of medical treatment and data analytics. […] The objective of this paper is to extract the activity and trends of coronavirus related research articles using machine learning approaches to help the research community for future exploration concerning COVID-19 prevention and treatment techniques. | 2020-08-25 |
| 32834647 | Mathematical models may help to explore the transmission dynamics, prediction and control of COVID-19 in the absence of an appropriate medication or vaccine. | 2020-08-25 |
| 32834651 | The international community tries to find, apply, or design novel methods for diagnosis and treatment of COVID-19 patients as soon as possible. | 2020-08-25 |
| 32834653 | In absence of any effective therapeutics or drugs and with an unknown epidemiological life cycle, predictive mathematical models can aid in understanding of both coronavirus disease control and management. | 2020-08-25 |
| 32834698 | From the perspective of modern medical mechanism, during the prevention and treatment of novel coronaviral infection, moxibustion may be able to prevent and treat COVID-19 by improving the body’s immunity so as to conquer virus, by anti-inflammation to alleviate the inflammatory response of COVID-19 and by improving lung function to inhibit pulmonary fibrosis. | 2020-08-25 |
| 32834718 | During the virtual visits, we discussed the clinical progress of patients, wound status, treatment modification, the time of return to work, postoperative complications, and the radiological data of the patients. | 2020-08-25 |
| 32834766 | For the treatment of various viral infections, antiviral drugs may be used. | 2020-08-25 |
| 32834785 | ASPs can also play a critical role in the management of potential drug shortages, developing local treatment guidelines, optimizing the use of antibiotics, and in the diagnostic stewardship of COVID-19 testing, among other roles. | 2020-08-25 |
| 32834792 | •There no evidence that treatment with RAAS blockers worsens the course of COVID-19. | 2020-08-25 |
| 32834831 | The proposed system would employ an Internet of Things (IoTs) framework to collect real-time symptom data from users to early identify suspected coronaviruses cases, to monitor the treatment response of those who have already recovered from the virus, and to understand the nature of the virus by collecting and analyzing relevant data. […] Based on these results we believe that real-time symptom data would allow these five algorithms to provide effective and accurate identification of potential cases of COVID-19, and the framework would then document the treatment response for each patient who has contracted the virus. | 2020-08-25 |
| 32834835 | Many plant-derived natural compounds (polyphenols) might provide a starting point for the research on the use of plant extracts in coronavirus treatment and prevention. | 2020-08-25 |
| 32834886 | The only currently effective treatment for obesity is metabolic surgery, which confers prompt, lasting benefits. | 2020-08-25 |
| 32834892 | Although we have not fully understood the physiological and pathological aspects of COVID-19, current research progress indicates the effectiveness of anti-cytokine therapy. | 2020-08-25 |
| 32834893 | Additionally, therapeutic strategies employed in HAE should be considered for the treatment of COVID-19, and clinical trials should be performed. | 2020-08-25 |
| 32834902 | Currently no therapeutics have been found to be effective. […] Investigational therapeutics are briefly discussed. | 2020-08-25 |
| 32834903 | We report the case of a child with asthma who sought care for COVID-19 symptoms whose condition did not improve despite appropriate treatment for asthma, pneumonia and COVID-19. | 2020-08-25 |
| 32834921 | When effective medical treatment and vaccination are not available, non-pharmaceutical interventions such as social distancing, home quarantine and far-reaching shutdown of public life are the only available strategies to prevent the spread of epidemics. | 2020-08-25 |
| 32834942 | Given those benefits, this review paper describes how N. sativa in combination with Zn could be useful as a complement to COVID-19 treatment. | 2020-08-25 |
| 32834946 | China has achieved rapid containment of this highly infectious disease following the principles of early detection, early quarantine and early treatment with integrated traditional Chinese and Western medicine. | 2020-08-25 |
| 32834947 | Therefore, effective prevention and treatment medications against human coronavirus are in urgent need. […] In this article, we provided a comprehensive review on the natural compounds that interfere with the life cycles of SARS and MERS, and discussed their potential use for the treatment of COVID-19. | 2020-08-25 |
| 32834948 | To date, there is no specific treatment proven effective against these viral infectious diseases. | 2020-08-25 |
| 32834950 | Chloroquine (CQ) phosphate has been suggested to be clinically effective in the treatment of coronavirus disease 2019 (COVID-19). | 2020-08-25 |
| 32834968 | First, we propose the use of Acceptance and Commitment Therapy for Moral Injury (ACT-MI) among individuals suffering from moral injury. | 2020-08-25 |
| 32834986 | In addition, rare and severe complications of current anticoagulation therapy is illustrated and discussed through one of the cases presented. | 2020-08-25 |
| 32834988 | Considering the high prevalence of thromboembolic events in COVID-19 patients it is mandatory for the emergency physician to systematically evaluate signs of pulmonary thromboembolism, in order to perform the most patient-tailored therapy as soon as possible. | 2020-08-25 |
| 32834991 | Recently, several studies reported SARS-CoV-2 ribonucleic acid (RNA) in wastewater treatment plant samples. | 2020-08-25 |
| 32834992 | Integration of Chinese medical drugs (CMD) and western medicine (WM) has been widely used in the treatment of Coronavirus Disease 2019 (COVID-19). | 2020-08-25 |
| 32835016 | We took care of her by following the rule for suspected infection patient, and safely completed her treatment without medical staff infection. | 2020-08-25 |
| 32835018 | Medical charts and images of six patients affected by stroke while being on ACE-Is and ARBs therapy before and during COVID-19 outbreak in Lombardy region, Italy, were reviewed. | 2020-08-25 |
| 32835020 | The aim of this study is to present our suggestions for organization, personal protective equipment (PPE) use, work flow of the operating theater, and the treatment of patients with COVID-19 and co-existing neurological disease. […] According to the therapeutic committee guidelines, chloroquine was started for COVID-19 treatment. […] No one from the stuff was infected during the treatment. | 2020-08-25 |
| 32835023 | We describe a patient in Tanzania who experienced severe headache for seven days before the onset of other symptoms of COVID-19 that led to her isolation, diagnosis, and treatment. | 2020-08-25 |
| 32835062 | In the following, we aim to discuss some of the ethical issues associated with the use of this treatment association. […] We mainly tried to discuss the following controversial questions: Is it ethical not to treat a patient while a treatment exists and is used for other indications than Covid-19 for which it’s not proven yet? […] If yes, is a randomized controlled trial to prove the hydroxychloroquine for the Covid-19 treatment, necessary, in the context of covid-19 pandemic? […] If no, is it the government’s right to decide the hydroxychloroquine treatment for all covid-19 patients? […] The paper conclude that, since health authorities in some countries recommended this off-label use treatment, physicians are challenged by the requirement of veracity while providing care to their patients and the implications of such a requirement; they are facing the challenge of balancing this guideline and their own conviction. | 2020-08-25 |
| 32835069 | Here, we measured the amount of SARS-CoV-2 RNA at the inflow point of the main waste water treatment plant (WWTP) of Montpellier, France. | 2020-08-25 |
| 32835072 | However, severity of infection, fatality rates, and treatment responses across different countries, age groups, and demographic groups suggest that the nature of infection is diverse, and a timely investigation of the same is needed for evolving sound treatment and preventive strategies. | 2020-08-25 |
| 32835074 | Taken together, our results present a novel understanding of genes and corresponding pathways upon SARS-Cov-2 infection, and could facilitate the identification of novel therapeutic targets and biomarkers in the treatment of COVID-19. | 2020-08-25 |
| 32835076 | Understanding the dynamics of this highly contagious SARS-CoV-2, which at present does not have any therapy assist the policy makers on evaluating the effectiveness of the control measures currently being implemented. | 2020-08-25 |
| 32835082 | However, there are several methods to detect COVID-19 positive patients, which are typically performed based on respiratory samples and among them, a critical approach for treatment is radiologic imaging or X-Ray imaging. | 2020-08-25 |
| 32835083 | According to the result, clinical assessment of these three herbal compounds and hsa-miR-1307-3p may have significant outcomes for the prevention, control, and treatment of COVID-19 infection. | 2020-08-25 |
| 32835090 | To date, there is no approved therapeutics or effective treatment available to combat the outbreak. […] This urgent situation is pressing the world to respond with development of novel vaccine or a small molecule therapeutics for SARS-CoV-2. […] The in vitro activity of selected inhibitors can be done easily which will provide useful information for clinical treatment of novel coronavirus pneumonia. | 2020-08-25 |
| 32835105 | Treatment is tocilizumab. […] In other very similar CSS, such as macrophage activation syndrome (MAS) and hemophagocytic syndrome (HFS), the main treatment are corticosteroids. | 2020-08-25 |
| 32835119 | The administration of the already started disease-modifying therapy (DMT) continued, and the introduction of the new one was postponed until the moment when the epidemic started to slow down. […] During the epidemic period, plasmapheresis treatment was performed in CN-CCM without any complications. | 2020-08-25 |
| 32835148 | Phase 3 aims to predict costs attributable to the modifications of the CRC services and additional resources required to treat patients whose treatment has been affected by the pandemic. | 2020-08-25 |
| 32835155 | Low-level detection of a targeted disease biomarker (pM level) has emerged extremely useful to evaluate the progression of disease under therapy. […] Such collected bioinformatics and its multi-aspects-oriented analytics is in demand to explore the effectiveness of a prescribed treatment, optimize therapy, and correlate biomarker level with disease pathogenesis. | 2020-08-25 |
| 32835159 | There is a growing body of evidence surrounding the findings on hybrid imaging with FDG-PET/CT, and this case highlights the importance of molecular imaging in better understanding of the biomarkers of the disease which ultimately determine the success in building a model to predict the disease severity and monitoring the response to treatment. | 2020-08-25 |
| 32835179 | Accordingly, this study puts forward the following countermeasures and suggestions for hospitals to deal with future biosecurity events, such as a major epidemic: first, biosecurity management systems and emergency response mechanisms in hospitals need to be set up; second, the investment and guarantee mechanisms for hospital biosecurity construction should be improved; third, the capacity building of biosecurity incident management requires special attention in general hospitals; and finally, comprehensive plans need to be developed for the integrated construction of medical treatment and prevention facilities through disease-control systems. | 2020-08-25 |
| 32835201 | With high transmissibility and no effective vaccine or therapy, COVID-19 is now a global pandemic. | 2020-08-25 |
| 32835210 | Glucocorticoid is considered effective in the treatment of patients diagnosed with severe COVID-19. | 2020-08-25 |
| 32835212 | Currently, no drugs/vaccine is available for the treatment of this disease. | 2020-08-25 |
| 32835213 | This review primarily discusses the drug development prospects of cyclophilin A as a therapeutic target for the treatment of coronavirus infection, especially coronavirus disease 2019 (COVID-19), and non-immunosuppressive cyclosporine analogues. | 2020-08-25 |
| 32835245 | The treatment effect of anakinra remained significant in the multivariate analysis (HR 0·22 [95% CI 0·10-0·49]; p=0·0002). | 2020-08-25 |
| 32835246 | It is therefore urgent to develop an effective therapy to treat patients with COVID-19 and to control the spread of the causative agent, severe respiratory syndrome coronavirus 2. […] As pathological examination has confirmed the involvement of immune hyperactivation and acute respiratory distress syndrome in fatal cases of COVID-19, several disease-modifying anti-rheumatic drugs (DMARDS), such as hydroxychloroquine and tocilizumab, have been proposed as potential therapies for the treatment of COVID-19. | 2020-08-25 |
| 32835256 | Mavrilimumab treatment was associated with improved clinical outcomes compared with standard care in non-mechanically ventilated patients with severe COVID-19 pneumonia and systemic hyperinflammation. […] Treatment was well tolerated. | 2020-08-25 |
| 32835257 | No therapy is approved for COVID-19 pneumonia. […] The aim of this study was to assess the role of tocilizumab in reducing the risk of invasive mechanical ventilation and death in patients with severe COVID-19 pneumonia who received standard of care treatment. […] Treatment groups were compared using Kaplan-Meier curves and Cox regression analysis after adjusting for sex, age, recruiting centre, duration of symptoms, and baseline Sequential Organ Failure Assessment (SOFA) score. […] After adjustment for sex, age, recruiting centre, duration of symptoms, and SOFA score, tocilizumab treatment was associated with a reduced risk of invasive mechanical ventilation or death (adjusted hazard ratio 0·61, 95% CI 0·40-0·92; p=0·020). 24 (13%) of 179 patients treated with tocilizumab were diagnosed with new infections, versus 14 (4%) of 365 patients treated with standard of care alone (p<0·0001). […] Treatment with tocilizumab, whether administered intravenously or subcutaneously, might reduce the risk of invasive mechanical ventilation or death in patients with severe COVID-19 pneumonia. | 2020-08-25 |
| 32835275 | Patients with human immunodeficiency virus/acquired immunodeficiency syndrome (HIV/AIDS) comprise a unique population whose clinical course may provide insights into the effects of antiretroviral therapy on COVID-19. | 2020-08-25 |
| 32835277 | Despite continued corticosteroid and tacrolimus therapy, he remained aviremic. | 2020-08-25 |
| 32835284 | After presenting a case of right ventricular thrombus in a patient with coronavirus disease-2019 (COVID-19), we discuss the unique challenges in the evaluation and treatment of COVID-19 patients, highlighting our COVID-19-modified pulmonary embolism response team algorithm. | 2020-08-25 |
| 32835296 | Our team and others have shown that AA may have anti-inflammatory properties that may contribute to their efficacy in the treatment of mental health disorders. […] Short-term treatment of healthy mice with a dose of RIS that achieves plasma concentrations within the low clinical range resulted in disrupted response to an inflammatory (LPS) challenge compared to vehicle controls. | 2020-08-25 |
| 32835304 | We hear about the difficulties of providing palliative care on the front, the challenges patients seeking gender-affirming surgeries face, the loss of rituals built into healthcare visits, the pivots researchers take to study SARS-CoV-2, as well as the unique mental health impact of an ongoing trauma. | 2020-08-25 |
| 32835314 | As the number of COVID-19 cases soars in epicenters, health officials are warning about the possibility of the designated treatment centers being overwhelmed by coronavirus patients. | 2020-08-25 |
| 32835316 | A total of 111 patients with COVID-19 underwent treatment with HCQ monotherapy (mean age 62 ± 16 years, 44 women [39%], serum creatinine 0.9 [interquartile range 0.4] mg/dL). […] A minority of patients demonstrated clinically significant QTc prolongation during HCQ therapy. | 2020-08-25 |
| 32835347 | New impediments to medication access and adherence have arisen. […] Barriers to medication access should be reviewed with patients at every contact, with implementation of strategies to ensure ongoing provision of medications. | 2020-08-25 |
| 32835351 | Due to the critical significance and increasing prevalence of the disease, several national and international societies have recently updated their guidelines for the diagnosis and treatment of HTN. | 2020-08-25 |
| 32835632 | Currently, there is no specific drug for the therapy of COVID-19. […] Drug repurposing of the available drugs would be great help in the treatment of COVID-19 infection. […] The combination therapy of the finding may improve inhibitory activity. | 2020-08-25 |
| 32835634 | Subsequently, data from various countries have revealed obesity as an independent and significant factor, with people who are overweight/have obesity significantly more likely to be hospitalized, require ICU treatment, and to die. […] This paper sets out the evidence of greater risk of poor COVID outcomes for people who are overweight/have obesity, indication of reduced treatment and support for obesity self-management where it existed prior to COVID-19, and highlights the dearth of specific guidance and measures to mitigate the impacts of COVID-19 upon people with obesity. | 2020-08-25 |
| 32835775 | Most people infected with the COVID-19 virus will experience mild to moderate respiratory illness and recover without requiring special treatment. | 2020-08-25 |
| 32835793 | Overall, these ocular symptoms, including burning sensations, epiphora and redness, seem to be mild and to not need treatment. | 2020-08-25 |
| 32835901 | Based on this hypothesis, several immunosuppressant agents are currently being tested as potential treatment for coronavirus 2019 (COVID-19). report a patient treated with alemtuzumab (Humanized monoclonal antibody against the lymphocyte and monocyte surface antigen CD52, which depletes B and T cells) (Thompson et al., 2018) for recurrent remittent multiple sclerosis (RRMS) who developed mild COVID-19. | 2020-08-25 |
| 32835962 | We investigated the possibility that SARS-CoV-2 emerged in Italy earlier than that date, by analysing 40 composite influent wastewater samples collected - in the framework of other wastewater-based epidemiology projects - between October 2019 and February 2020 from five wastewater treatment plants (WWTPs) in three cities and regions in northern Italy (Milan/Lombardy, Turin/Piedmont and Bologna/Emilia Romagna). | 2020-08-25 |
| 32836085 | Additionally, treatment with positive airway treatment devices (PAP) can be challenging because of PAP-induced droplets and aerosol. | 2020-08-25 |
| 32836117 | This review aims to critically evaluate the incidence of gastrointestinal (GI) symptoms, the quantity and infectivity of SARS-CoV-2 in feces and urine, and whether these pose an infection risk in sanitary settings, sewage networks, wastewater treatment plants, and the wider environment (e.g. rivers, lakes and marine waters). […] In addition, while SARS-CoV-2 RNA genetic material can be detected by in wastewater, this signal is greatly reduced by conventional treatment. | 2020-08-25 |
| 32836301 | Thus, faced up with the injunction of confinement, they show themselves in the psychic impossibility of following the treatment by other means such as, for example, telephone sessions. | 2020-08-25 |
| 32836304 | The modalities of psychotropic treatment are very important in this specific pathologic case and our presentation could give us new ideas in psychiatry and immunology about protection by ay antibiotherapy in pre- and post-operatory. | 2020-08-25 |
| 32836361 | This article provides structured recommendations for HCP to adapt to the situation, optimize treatment protocols with judicious use of all resources while providing evidence-based treatment for sarcoma patients. | 2020-08-25 |
| 32836364 | In metastatic cases, majority preferred either no treatment or non-surgical intervention (71%).84.5% believed in adapting changes (42%-avoid supra major surgeries, 27%-Operating only emergency cases and 15.5%-High grade sarcomas with curative intent) in surgical management of sarcomas. | 2020-08-25 |
| 32836376 | Consequently, we introduce major premises and techniques borrowed from Accelerated Experiential Dynamic Psychotherapy as they may apply to teletherapy. […] The model visually illustrates the matching of therapeutic interventions to the handling of the psychological upheavals triggered by the changes imposed by the pandemic, particularly the move to teletherapy. […] In addition to theoretical and practical suggestions, which could be adapted to various models of therapy, we present a brief clinical case demonstrating the application of the suggested therapeutic thinking and interventions. | 2020-08-25 |
| 32836378 | The coronavirus pandemic and the move to teletherapy has created uncertainty among both clinicians and patients. […] As therapists who work with children, we have heard from parents who are desperate for support and advice about how to respond to their children’s behavioral changes, as well as those who feel too overwhelmed to continue their children’s sessions at the moment and want to take a break from treatment. […] This paper will describe how the Mentalization-Based Treatment for Children (MBT-C) model offers a framework for an integrative approach that can inform treatment via teletherapy, so that clinicians can continue supporting young people and their families through this period. […] Finally, we illustrate with clinical vignettes how the developmental levels of mentalizing-attention control, emotion regulation, and explicit mentalizing-can inform the structure, techniques and interventions in teletherapy with children and parents. | 2020-08-25 |
| 32836379 | Clinicians may employ empirically supported interventions derived from cognitive behavioral therapy (CBT) and related therapies. | 2020-08-25 |
| 32836394 | Due to the clinical severity intravenous antibiotic treatment was started immediately. […] The clinical condition of the infant rapidly improved but whether this was due to symptomatic or antibiotic treatment remained unknown. […] There is still a considerable lack of experience regarding diagnostics and treatment of pediatric SARS-CoV-2 infections. | 2020-08-25 |
| 32836538 | Patients suffering from the illness have placed unprecedented demands on acute care, particularly on Intensive Care Units (ICUs). | 2020-08-25 |
| 32836600 | We calibrate our model with data on cumulative detected infections and deaths from the Robert-Koch Institute and demonstrate how the model can be used to obtain county- or even city-level estimates on the number of new infections, hospitality rates and demands on intensive care units. | 2020-08-25 |
| 32836623 | The interview ends with her thoughts on whether we should assume that the landscape of analytic therapy will be permanently altered by Covid-19, and with her hope that general awareness of the impact of trauma on our mental health has been raised. | 2020-08-25 |
| 32836666 | It is unclear whether previous treatment with angiotensin-converting enzyme inhibitors (ACEI) and angiotensin receptor blockers (ARB) affects the prognosis of COVID-19 patients. […] The aim of this study was to evaluate the clinical implications of previous treatment with ACEI/ARB on the prognosis of patients with COVID-19 infection. […] Of the total population, 447 979 inhabitants, 965 patients (0.22%) were diagnosed with COVID-19 infection, and 210 (21.8%) were under ACEI or ARB treatment at the time of diagnosis. […] Treatment with ACEI/ARB (combined and individually) had no effect on mortality (OR, 0.62; 95%CI, 0.17-2.26; P = .486), heart failure (OR, 1.37; 95%CI, 0.39-4.77; P = .622), hospitalization rate (OR, 0.85; 95%CI, 0.45-1.64; P = .638), ICU admission (OR, 0.87; 95%CI, 0.30-2.50; P = .798), or major acute cardiovascular events (OR, 1.06; 95%CI, 0.39-2.83; P = .915). […] Previous treatment with ACEI/ARB in patients with COVID-19 had no effect on mortality, heart failure, requirement for hospitalization, or ICU admission. | 2020-08-25 |
| 32836711 | It was estimated that shortfall of specialists to operate ventilators for COVID-19 intensive care units was approximately 40,000. | 2020-08-25 |
| 32836736 | The purpose of this paper is to review the concept of parental burnout, discuss parental burnout in the context of the current COVID-19 pandemic, and focus specifically on the effects of child maltreatment. | 2020-08-25 |
| 32836805 | Due to the strong infectivity of COVID-19, it spread all over the world in about three months and thus has been studied from different aspects including its source of infection, pathological characteristics, diagnostic technology and treatment. | 2020-08-25 |
| 32836837 | In a pre-registered online experiment (N = 1081), we randomly allocated subjects to either a control group or to one of three narrative treatment groups, each presenting a different likely cause of the COVID-19 outbreak: an animal cause; an animal and human cause (AHC); and an animal, human or lab cause. | 2020-08-25 |
| 32836868 | Exploring heterogeneous treatment effects reveals that younger respondents are more susceptible to Deontological appeals. | 2020-08-25 |
| 32836895 | Due to the pandemic caused by the coronavirus disease 2019 (COVID-19) and the resulting constraints on personal (i.e. face to face) treatment, video consultations have recently gained a major role in the delivery of healthcare services; however, until now, most psychotherapists have little experience with conducting video consultations, not least because of poor possibilities for reimbursement from the statutory health insurance. | 2020-08-25 |
| 32836899 | Of the men two were invasively ventilated in the intensive care unit and one man died after 8 days in domestic quarantine without treatment. | 2020-08-25 |
| 32837030 | Documented scientific evidences in similar viral outbreaks in past suggested few therapy regimens. […] So, in the current review, we are exploring novel treatment strategies and therapies that are being explored and are in clinical and preclinical stages of research. […] The term “Stem Cell therapy and COVID-19”, “Mesenchymal stem cell and corona 2019 virus”, “DNA Vaccines and COVID-19, RNA Vaccines and COVID-19” and “Cell-based therapy with SARS-CoV-2, University/Institutions and COVID-19 research” were used. […] Similarly, few others like repurposing of drugs, Nano Vaccines, other miscellaneous trials of Herbs, Music therapy etc., were also excluded. […] In the present review, we have included the various novel therapies like stem cell therapy, DNA or RNA vaccines which are under development and if proven successful may have a lasting impact on the health industry. | 2020-08-25 |
| 32837035 | Many interventions are being explored for the prophylaxis and treatment of COVID-19 in all over the world including India. […] More number of trials were for treatment as compared to prophylaxis. | 2020-08-25 |
| 32837046 | Delaying surgery or planning alternative treatment in patient care should be done by taking input from experts in thoracic specialties. | 2020-08-25 |
| 32837081 | Hospital visits, investigations and all modalities of treatment have potential complications that put patients at risk, some more than others. | 2020-08-25 |
| 32837094 | Concerns were raised by the recipients mostly regarding the uncertainties of COVID-19 infection and its treatment options, the quality of information on social messaging platforms, and lack of access to routine tests/immunosuppression levels because of lockdown/social distancing. | 2020-08-25 |
| 32837097 | There is an urgent unmet need of interventions both for prevention and treatment of this disease and more than 500 clinical trials are ongoing in this regard. […] At present, no study with robust methodology have clearly demonstrated benefits of hydroxychloroquine for treatment, preexposure prophylaxis in healthcare workers or post exposure prophylaxis in COrona VIrus Disease-2019. […] Given the rapid pace of clinical information and discoveries, it is important for clinicians to be up to date with the latest, evidence-based treatment options available for this novel disease. | 2020-08-25 |
| 32837105 | The aim of this study is to analyze the effectiveness of proactive telemedicine in maintaining follow-up of orthopedic patients, and their satisfaction with telemedicine as an alternative mode of treatment delivery. […] Patients were asked to complete a questionnaire that included overall patient satisfaction with telemedicine, its effectiveness, and ease in following the telemedicine-based treatment. | 2020-08-25 |
| 32837108 | The paper reports the experiences in treatment of two cases of corona virus disease 2019 (COVID-19) with the combination of acupuncture and medication in bedridden patients confirmed in C7 Inpatient Ward, Wuhan Leishenshan Hospital, China. […] The combined treatment of acupuncture with the oral administration of “Shanghai leishen No.1 formula” was given every day. […] Besides, the antivirus, anti-infectious and symptomatic treatment of western medicine was combined. […] It is anticipated that the treatment experiences in these two cases may provide the instruction and enlightenment for the prevention and treatment of COVID-19. | 2020-08-25 |
| 32837109 | Acupuncture therapy plays its active adjuvant effect in the whole process of the treatment of COVID-19. | 2020-08-25 |
| 32837110 | To observe the clinical therapeutic effect of adjuvant treatment with heat-sensitive moxibustion for coronavirus disease 2019 (COVID-19) of the ordinary type. […] The number of cases was reduced to be 10 cases (23.8%), 7 cases (16.7%) and 4 cases (9.5%) after the 1st treatment of heat-sensitive moxibustion for chest oppression, poor appetite, and lassitude. […] It was reduced to be 11 cases (26.2%), 8 cases (19.0%) and 4 cases (9.5%) after the 2nd treatment of moxibustion and it was reduced to be 18 cases (42.9%), 10 cases (23.8%) and 6 cases (14.3%) after the 3rd treatment of moxibustion. […] The incidences of the symptoms were all reduced obviously as compared with those before treatment. […] (2) Before treatment with heat-sensitive moxibustion, there were 24 cases of negative emotions (57.1%). […] It was reduced to be 16 cases (38.1%), 11 cases (26.2%) and 3 cases (7.1%) after the 1st, 2nd and 3rd treatment of heat-sensitive moxibustion successively. […] The incidences were all reduced obviously as compared with those before treatment. […] (3) After the 1st treatment, the active acceptance rate of heat-sensitive moxibustion was 100% (42/42) in the patients, higher than 11.9% (5/42) before treatment. […] Adjuvant treatment with heat-sensitive moxibustion effectively relieves the symptoms of COVID-19 such as chest oppression, poor appetite and lassitude, and alleviates the negative emotions, such as tension and anxiety. […] This therapy improves the therapeutic effect of COVID-19 and deserves to be promoted in clinical practice. | 2020-08-25 |
| 32837113 | There are no approved antiviral drugs or vaccines for the treatment of human CoV infection to date. | 2020-08-25 |
| 32837118 | Some drugs such as lopinavir, simeprevir, hydroxychloroquine, chloroquine, and amprenavir have been recommended for COVID-19 treatment by some researchers, but these drugs were not effective enough against this virus. […] Also, molecular dynamics (MD) simulation indicates that binding of the combination therapy of simeprevir and the candidate studied compounds to the receptors was stable and had no major effect on the flexibility of the protein throughout the simulations and provided a suitable basis for our study. […] So, this study suggested that caulerpin and its derivatives could be used as a combination therapy along with lopinavir, simeprevir, hydroxychloroquine, chloroquine, and amprenavir for disrupting the stability of SARS-CoV2 receptor proteins to increase the antiviral activity of these drugs. | 2020-08-25 |
| 32837119 | Although after the continuous scientific efforts, we are still not having any specific drug or vaccine for the SARS-CoV-2 pathogen to date and there is an urgent need to develop a newer therapy to counter the COVID-19 global pandemic. […] Thus, in the current study, a framework for computational drug repurposing is established, and based on their safety profile, metocurine was chosen as a safe and effective drug candidate for developing therapy against the viral Mpro enzyme of SARS-CoV-2 for the treatment of COVID-19. | 2020-08-25 |
| 32837137 | Intensive research on SARS-CoV-2 is urgently warranted to understand its pathogenesis and virulence mechanisms and to discover target-based antiviral therapeutics. | 2020-08-25 |
| 32837160 | The ability to monitor and report maltreatment has been severely limited for organizations that work with children of abuse and neglect; this is particularly troubling given that abuse and neglect are likely to rise during times of distress and turmoil. […] The purpose of this paper is to discuss the importance of organizations that work with children exposed to maltreatment, highlight the novel approach of Child Advocacy Services, SEGA, Inc. | 2020-08-25 |
| 32837192 | Accurate information on the disease, its prevention and treatment can be disseminated through drug information centers (DICs). […] In addition to health and drug information, pharmacists working in the DICs can be involved in the management of the patients’ health by providing information on home care and safety, medication management of patients with chronic comorbid illnesses, and psychological advice. | 2020-08-25 |
| 32837193 | Salbutamol, a short-acting β-agonist (SABA), could be a life-saving medication during critical conditions. […] We also highlight the important role of physicians and pharmacists in optimizing medication therapies to ensure adequate supplies. | 2020-08-25 |
| 32837194 | COVID-19 patients may present high risk in the use of medications and clinical pharmacists can contribute substantially as part of a multidisciplinary team to improve outcomes in drug therapy in severe and critical illness. | 2020-08-25 |
| 32837197 | It is not known for certain if there is an association between any pharmacological agent used for rheumatologic treatment, including biological and non-biological disease-modifying antirheumatic drugs (DMARDs), and an increased risk of COVID-19 acquisition or adverse outcomes from COVID-19, although these agents have been associated with an overall higher risk of infections. […] The pharmacological management of patients with a rheumatic disease without COVID-19 should currently follow usual treatment approaches. […] Patients receiving antimalarials (hydroxychloroquine/chloroquine) may continue treatment with these agents. […] Treatment with sulfasalazine, methotrexate, leflunomide, immunosuppressants and biological agents other than interluekin-6 receptor inhibitors and JAK inhibitors should be stopped or withheld. […] It should be reasonable to resume DMARD treatment when patients are no longer symptomatic and at least 2 weeks after documentation of COVID-19, although the decision should be individualized, preferably based on infection severity. | 2020-08-25 |
| 32837207 | More than 20 % of ICU COVID-19 patients require extra renal replacement therapy (ERT) for acute renal failure that is made difficult by the hypercoagulable state of these patients, responsible for filter thrombosis. | 2020-08-25 |
| 32837212 | In case of feeding intolerance refractory to a prokinetic treatment, complementary or total parenteral nutrition is advised, favouring new generation mixed lipid emulsions (containing fish oil) and regular monitoring of triglyceridemia. | 2020-08-25 |
| 32837214 | The thrombotic risk can be scored to adapt the thromboprophylactic treatment, impaired renal function and overweight making it even more difficult. | 2020-08-25 |
| 32837217 | Effective target therapy for renal injury has yet been developed. […] Nevertheless, the molecular mechanisms of CHM treatment are still unclear. […] In this study, we searched prescriptions in the treatment of renal injury extensively and the potential mechanisms to treat COVID-19 related renal injury were investigated. | 2020-08-25 |
| 32837218 | Self-medication plays a key role in public health as it influences both negatively and positively on the health of individuals and the existing healthcare systems. […] The study aimed at assessing the prevalence of self-medication before and during the outbreak of COVID-19 pandemic among healthcare workers and its associated factors. […] The overall prevalence of self-medication increased from 36.2% (n = 137) before the pandemic to 60.4% (n = 229) during the pandemic. […] The respondents’ gender, level of education, age, marital status, participation in physical activity, and drug reaction events, were significantly associated with self-medication before and during the outbreak (P < 0.05). […] Self-medication is an important health issue, especially during the COVID-19 pandemic. […] Continuous awareness creation and sensitization could help in reducing self-medication practices among healthcare workers. | 2020-08-25 |
| 32837219 | There has been no vaccines or drugs available for the treatment of human coronavirus infections to date. | 2020-08-25 |
| 32837283 | Due to the unavailability of specific treatment for the COVID-19, it can be viewed that the risk of cluster infection will continue to be present within the intermittent and small-scale outbreaks. | 2020-08-25 |
| 32837285 | Therefore, we should not expect COVID-19 risks in treatment plant effluents. | 2020-08-25 |
| 32837296 | There is no evidence for a deterioration of COVID-19 through CPAP therapy. […] In principle, the application of positive pressure therapy via various mask systems can be accompanied by the formation of infectious aerosols. […] In the case of confirmed infection with SARS-CoV2, a pre-existing PAP therapy should be continued in an outpatient setting in accordance with the local guidelines for home isolation, since discontinuation of PAP therapy is associated with additional cardiopulmonary complications due to the untreated sleep-related breathing disorder. […] According to the current state of knowledge inhalation therapy, nasal high-flow (NHF), and PAP therapy can be carried out without increased risk of infection for health care workers (HCW) as long as appropriate personal protective equipment (eye protection, FFP2 or FFP-3 mask, gown) is being used.This position paper of the German Society for Pneumology and Respiratory Medicine (DGP) and the German Society for Sleep Medicine (DGSM) offers detailed recommendations for the implementation of sleep medicine diagnostics and therapy in the context of the coronavirus pandemic. | 2020-08-25 |
| 32837302 | The algorithm covers some key points of decision making such as clinical signs, first contact, admission for in-patient treatment, consequences of swab and computed tomography (CT) results, and allocation and isolation measures within the hospital. […] The algorithm is not intended to guide diagnostics, decisions and treatment in the narrower medical sense but to provide more general instructions for the management of in-patients considering specific aspects of SARS-CoV‑2. | 2020-08-25 |
| 32837305 | Close cooperation with other specialist areas such as hygiene, infectiology or virology is also necessary in order to implement appropriate treatment concepts before, during and after the diagnosis is completed. | 2020-08-25 |
| 32837329 | The great majority of therapists thought that remote working skills should be part of formal therapy trainings. | 2020-08-25 |
| 32837330 | We aim to provide a multi-systemic perspective of mental health and well-being in the time of COVID-19, as well as encourage current and future studies to incorporate these suggestions to advance the health and well-being of our communities through evidence-based treatment approaches. | 2020-08-25 |
| 32837354 | This study evaluated nurses’ perceptions of a rapidly deployed critical care education program conducted to prepare a community hospital for its transformation to a COVID-19 treatment center. | 2020-08-25 |
| 32837392 | Given the current challenges facing C/L psychiatry and the mental health field in general, there is an urgent need to overcome stigma and financial barriers to make treatment readily accessible. | 2020-08-25 |
| 32837398 | APRNs must remain current on best practices for treatment and diagnosis of COVID-19 while being cognizant of changes to their scope of practice. | 2020-08-25 |
| 32837409 | Guidelines for physical therapy management of patients hospitalized with COVID-19 recommend limiting physical therapists’ contact with patients when possible. […] Our facility developed an algorithm for the use of a physical therapy telerehabilitation program for inpatients with COVID-19. | 2020-08-25 |
| 32837425 | Based on the present findings, the potential utility of acceptance and commitment therapy is discussed within the context of COVID-19. | 2020-08-25 |
| 32837492 | Plasma treatment is still emerging as a new healthcare technology, but it is showing a strong potential for treatment of many diseases including cancers and antimicrobial-resistant infections, with little or no adverse side effects. […] Here, we argue that with the ever-increasing complex healthcare challenges facing communities, including the ongoing COVID-19 pandemic, it is critical to consider combining unique properties of emerging healthcare technologies into a single multimodal treatment modality that could lead to unprecedented healthcare benefits. | 2020-08-25 |
| 32837504 | The international guidelines for the prevention and treatment of the COVID-19 pandemic have been frequently updated. […] Nearly 35% preferred self-medication. […] Nevertheless, the tendency towards self-medication was reported by one-third of the responders. | 2020-08-25 |
| 32837505 | Additionally, RdRp could be a major target in the development of antivirals for the treatment of COVID-19. | 2020-08-25 |
| 32837529 | The aim of this study is to present guidelines for the care and treatment of people with IDs during the COVID-19 pandemic for both community teams providing care to people with IDs and inpatient psychiatric settings. […] The guidelines cover specific issues associated with hospital passports, individual COVID-19 care plans, the important role of families and carers, capacity to make decisions, issues associated with social distancing, ceiling of care/treatment escalation plans, mental health and challenging behavior, and caring for someone suspected of contracting or who has contracted SARS-CoV-2 within community or inpatient psychiatric settings. | 2020-08-25 |
| 32837538 | Thus, our data suggest that potential compounds in Rhizoma Polygonati may act on different targets and have a great potential in treatment of COVID-19. | 2020-08-25 |
| 32837552 | Facing the possibility of a surge of COVID-19-infected patients requiring ventilatory support in Intensive Care Units (ICU), the Singapore Hospice Council and the Chapter of Palliative Medicine Physicians forward its position on the guiding principles that ought to drive the allocation of ICU beds and its role in care of these patients and their families. | 2020-08-25 |
| 32837555 | A patient’s age serves as a very useful guide to physicians in deciding what disease manifestations to anticipate, what treatment to offer for certain conditions, and how to prepare for possible emergencies. […] In the context of the COVID-19 pandemic, determining treatment options on the basis of a patient’s chronological age can easily give rise to unjustified discrimination. […] This paper examines the fairness of recommendations contained in resource allocation guidelines in the Philippines that have implications for the way elderly patients could be treated or excluded from some forms of critical care treatment in the context of the ongoing Corona virus emergency. | 2020-08-25 |
| 32837563 | Palliative care aims to mitigate suffering caused by a life-limiting illness, and this crisis has led to the awareness and urgency to ensure it reaches all who needs it. […] We share here the palliative care perspectives and ethical challenges during the COVID-19 pandemic in Malaysia. | 2020-08-25 |
| 32837565 | Although there are no specific antiviral therapies that have proven effective in randomized clinical trials, currently, the rapid detection technology along with several promising therapeutics for COVID-19 have mitigated its drastic transmission. | 2020-08-25 |
| 32837573 | Patients with chronic kidney diseases are particularly at risk of infections and must therefore be protected against the risks of infection in dialysis treatment. | 2020-08-25 |
| 32837582 | The purpose of this review is to summarize emerging technologies being implemented in the study, diagnosis, and treatment of COVID-19. […] Key focus areas include the applications of artificial intelligence, the use of Big Data and Internet of Things, the importance of mathematical modeling for predictions, utilization of technology for community screening, the use of nanotechnology for treatment and vaccine development, the utility of telemedicine, the implementation of 3D-printing to manage new demands and the potential of robotics. | 2020-08-25 |
| 32837584 | New technologies are being developed toward the novel coronavirus SARS-CoV-2 to understand its pathogenesis and transmission, to develop therapeutics and vaccines, and to formulate preventive strategies. | 2020-08-25 |
| 32837586 | Safe and effective mitigating agents are needed for treatment and prevention of thrombotic complications in COVID-19 patients. […] This simple microfluidic device holds potential to be developed into a tool for assessing the effects of anticoagulant therapy on hemostasis. | 2020-08-25 |
| 32837592 | We have therefore reviewed and analyzed the literature with respect to a possible increased risk of infection for patients during treatment in the GHG. | 2020-08-25 |
| 32837669 | The patient’s condition improved significantly after going into intensive care and only symptomatic treatment. | 2020-08-25 |
| 32837672 | Our case highlights the importance of considering SARS-Cov-2 infection in the differential diagnosis for patients with unexplained central nervous system dysfunction and cerebral edema to prevent delayed diagnosis and render rapid treatment. | 2020-08-25 |
| 32837683 | Dental treatment necessitates close-proximity, face-to-face practices and can generate droplets or aerosols containing water, saliva, blood, microorganisms, and other debris during the procedure. […] Given the highly contagious nature of SARS-CoV-2, it is imperative to institute an appropriate standard procedural policy for patient management and recommendation of dental treatment at hospitals during the COVID-19 pandemic. | 2020-08-25 |
| 32837688 | They often require immediate dental treatment for severe pain and greater precautions are needed to cope with COVID-19. […] For behavior management, dental treatment is often provided under general anesthesia with meticulous preoperative evaluation and the use of high-quality viral filters. […] These recommendations for dental treatment of the disabled are based on 6 months of authors COVID-19 pandemic experience. | 2020-08-25 |
| 32837699 | This has required them to rapidly shift their treatment modality. | 2020-08-25 |
| 32837702 | With the COVID-19 pandemic resulting in social-distancing recommendations, many service providers find themselves altering the way they must provide medically necessary therapy. | 2020-08-25 |
| 32837706 | Acceptance and commitment therapy (ACT), born of behavior analysis, can help address some of these problems by encouraging behavioral change and increasing psychological flexibility. | 2020-08-25 |
| 32837729 | She had a history of type 2 diabetes mellitus and human immunodeficiency virus (HIV) infection, for which she reported non-compliance with treatment. | 2020-08-25 |
| 32837733 | We came to think that there is a need to discuss safe prevention and medical treatment for heatstroke. […] Based on the above, we have determined that guidance in clinical practice is necessary not only from the viewpoint of heatstroke prevention, but also from the viewpoint of medical treatment. | 2020-08-25 |
| 32837736 | The 111 suspected patients admitted to the emergency isolation ward have been scientifically diagnosed and treated, the three confirmed patients have received appropriate treatment. | 2020-08-25 |
| 32837740 | In the absence of a vaccine or treatment, the most pragmatic strategies against an infectious disease pandemic are extensive early detection testing and social distancing. | 2020-08-25 |
| 32837741 | Tocilizumab (TCZ) in its intravenous (IV) form of administration -RoActemra® 20 mg/mL (Roche)- is indicated for treatment of severe CRS patients. […] It is important to remember that during the current pandemic all the medicines are used off-label, since none of them has yet been approved for the treatment of COVID-19. | 2020-08-25 |
| 32837744 | The nomogram we constructed is useful for clinicians to predict improved clinical outcome probability for each COVID-19 patient, which may facilitate personalized counselling and treatment. | 2020-08-25 |
| 32837750 | Participants with positive tests of throat swab virus nucleic acid are randomized (1:1) into two groups: standard therapy plus TZV or standard therapy plus placebo for a 7-day treatment with a 21-day follow-up. […] The results of this trial should provide evidence-based recommendations to clinicians for the treatment of COVID-19. | 2020-08-25 |
| 32837758 | In this article, we drafted the recommendations for diagnosis and treatment of emergency surgeries in otorhinolaryngology, head and neck surgery in the epidemic area of novel coronavirus pneumonia based on “Novel Coronavirus Pneumonia Diagnosis and Treatment Plan (Provisional; 7th Edition Revisions)”and WHO guidelines, combined with the experience of emergency surgeries in the Department of Otorhinolaryngology, Wuhan Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, which is at the center outbreak area of the SARS-CoV-2 pneumonia (COVID-19) in China, to improve the success rate of treatment for otorhinolaryngology, head and neck surgery emergency surgeries and to reduce the SARS-CoV-2 infection rate in the perioperative period. | 2020-08-25 |
| 32837760 | Patients requiring urgent or emergent mastoidectomy during the COVID-19 pandemic require prompt treatment. | 2020-08-25 |
| 32837801 | The purpose of the review is to describe the Brazilian Telemedicine University Network RUTE concerning the Special Interest Group of Children and Adolescents, the new SIG-COVID19-BR activities for continuing medical education, and to update relevant information regarding diagnosis and treatment, using digital technologies. | 2020-08-25 |
| 32837809 | The increasing number of critical patients who, experiencing respiratory failure from acute respiratory distress syndrome, need respiratory support, has been leading countries to race against time in arranging new Intensive Care Units (ICUs) and in finding affordable and practical solutions to manage patients in each stage of the disease. | 2020-08-25 |
| 32837810 | Radiotherapy is life-saving treatment which ought to be guaranteed for all cancer patients who are indicated. […] The safety measures were indexed on a 16-point questionnaire covering 5 main areas of staffing, radiotherapy environment, equipment and treatment protocols, patient condition and scheduling, and education/sensitization. | 2020-08-25 |
| 32837811 | One of the best approaches for responding to COVID-19 is rapid detection, early isolation, and quick treatment of the disease. | 2020-08-25 |
| 32837819 | Relief measures instituted by World Bank Group (WBG) and International Monetary Fund (IMF) to help in the prevention, detection and treatment of coronavirus amidst SSA non-monetary measures and business support interventions are highlighted. | 2020-08-25 |
| 32837839 | While the final cost on human lives and world economy remains unpredictable, the timely identification of a suitable treatment and the development of an effective vaccine remain a significant challenge and will still require time. | 2020-08-25 |
| 32837845 | Surgery is an integral part of universal health offering life-saving therapy for a variety of illnesses. […] Surgical conditions are non-contagious without the risk for disease outbreaks, hardly preventable and their treatment is often infrastructurally demanding. | 2020-08-25 |
| 32837847 | A total of 20 mild and common COVID-19 patients were enrolled and randomly assigned to receive azvudine and symptomatic treatment (FNC group), or standard antiviral and symptomatic treatments (control group). […] The mean times of the first NANC of 4 newly diagnosed subjects in the FNC group and 10 subjects in the control group were 2.50 (SD 1.00; range 2-4) days and 9.80 (SD 4.73; range 3-19) days, respectively (starting from the initial treatment) (p = 0.01). […] The preliminary results showed that FNC treatment in the mild and common COVID-19 may shorten the NANC time versus standard antiviral treatment. | 2020-08-25 |
| 32837848 | Thus, in this work the recent literature surrounding the biology, clinical manifestations, and immunology of SARS-CoV-2 is summarized, with the aim of aiding prevention, diagnosis, and treatment for SARS-CoV-2 infection. | 2020-08-25 |
| 32837851 | In this review, we summarize the drugs used for COVID-19 treatment in China based on the emerging basic and clinical data. […] It is hoped that this review will be useful to provide guidance for the prevention, treatment, and control of COVID-19. | 2020-08-25 |
| 32837852 | Clinical pharmacology is an essential core competency for all health professionals, correlating with ability to appropriately and safely prescribe, administer, or optimize medication regimens. | 2020-08-25 |
| 32837853 | In the absence of effective treatment, off-label drug use, in lieu of evidence from published randomized, double-blind, placebo-controlled clinical trials, is common in COVID-19. | 2020-08-25 |
| 32837872 | Targeting LSD1 has been recognized as a promising therapeutic option for cancer treatment. | 2020-08-25 |
| 32837879 | Early diagnosis and detection of triazole resistance are essential for appropriate antifungal therapy to improve outcome in patients with coronavirus associated invasive aspergillosis. | 2020-08-25 |
| 32837889 | Transdiagnostic interventions, such as Acceptance and Commitment Therapy, that target psychological flexibility may be useful as the impact of the pandemic continues to unfold. | 2020-08-25 |
| 32837890 | Chinese herbal medicine is incorporated into the Chinese national guideline for COVID-19 management, emphasising the individualisation of herbal treatment guided by pattern differentiation, which is an ICD-11-endorsed approach. | 2020-08-25 |
| 32837891 | There is currently insufficient evidence to recommend quercetin supplementation as a therapy for the treatment or prevention of COVID-19. […] Current evidence on the efficacy of quercetin supplementation in the treatment and prevention of COVID-19 is insufficient for its clinical recommendation at this time. | 2020-08-25 |
| 32837893 | Oral vitamin C may assist with the symptoms of acute respiratory viral infections (ARI) and common cold-induced asthma but no studies have been identified justifying oral vitamin C for the prevention or treatment of coronavirus infections including COVID-19. | 2020-08-25 |
| 32837894 | Current evidence suggests that Echinacea supplementation may decrease the duration and severity of acute respiratory tract infections; however, no studies using Echinacea in the prevention or treatment of conditions similar to COVID-19 have been identified. […] Few adverse events were reported, suggesting that this herbal therapy is reasonably safe. […] Echinacea supplementation may assist with the symptoms of acute respiratory infections (ARI) and the common cold, particularly when administered at the first sign of infection; however, no studies using Echinacea in the prevention or treatment of conditions similar to COVID-19 have been identified. […] The studies reporting benefit used E. purpurea or a combination of E. purpurea and E. angustifolia containing standardized amounts of active constituents.Few adverse events from the use of Echinacea were reported, suggesting that this herbal therapy is reasonably safe. | 2020-08-25 |
| 32837896 | Current experimental evidence remains inconclusive regarding the effects of vitamin D supplementation in the general population for the prevention and treatment of acute respiratory tract infections (ARTI). […] Future clinical trials on vitamin D should consider the sources of heterogeneity in the existing experimental research and design trials that account for baseline status, evaluate the potential for prevention and treatment in at risk populations, standardize dosing strategies, assess product quality, assess outcomes according to gold standard definitions/diagnostic methods, and delineate viral ARTI from other causes when possible. | 2020-08-25 |
| 32837900 | Currently, there is insufficient evidence to recommend the use of this supplement in the treatment or prevention of COVID-19. | 2020-08-25 |
| 32837922 | The most prominent is their ability to be used as the last line of therapy for bacterial and viral infections including recent COVID-19. | 2020-08-25 |
| 32837941 | Though the decision regarding treatment is surgeon’s discretion, we hope these guidelines will help in decision making. | 2020-08-25 |
| 32837954 | Unfortunately, researchers could not find a registered therapy to treat the infection related to the virus yet. | 2020-08-25 |
| 32837965 | As a result of the significant circumstances, delaying diagnosis and treatment of AA during SARS-Cov-2 pandemic, inappropriate management of this common surgical disorder has been noticed. | 2020-08-25 |
| 32837982 | The urge to find a resultful treatment or cure is now pressing more than any other time since the outbreak of the pandemic. […] Here, we discuss five of the most promising drugs that can potentially play a major role in the treatment of COVID-19. […] While clinical trials for some of these drugs have already started, it is common knowledge that lack of organization between countries, institutes and hospitals might slow down the whole process for an official treatment based in wide, randomized, placebo controlled trials. | 2020-08-25 |
| 32837983 | Finally, we explore the possibility of improving the quality of monitoring and treatment of COVID-19 patients and in reducing the incidence of critical illness and mortality via better distinguishing hyper- and hypo-inflammatory subphenotypes of COVID-19. | 2020-08-25 |
| 32837984 | The chloroquine was suggested a potential drug against SARS-CoV-2 infection due to its in vitro antiviral effects, it is imperative high-quality data from worldwide clinical trials are necessitated for an approved therapy. […] In terms of hydroxychloroquine (HCQ) therapy, although WHO has stopped all the clinic trials due to its strong side-effects in COVID patients, large scale clinical trials with a long-term outcome follow-up may warrant HCQ and azithromycin combination in combating the virus. […] Convalescent plasma (CP) therapy suggested its safety use in SARS-CoV-2 infection; but both CP immunotherapy and NK cellular therapy must be manufactured and utilized according to scrupulous ethical and controlled conditions to guarantee a possible role of these products of human origin. | 2020-08-25 |
| 32837999 | Moreover, the decision to put restrictions on treatment beneficence is not discretionary, but an indispensable response to the overwhelming impacts of COVID-19 pandemic. | 2020-08-25 |
| 32838006 | The follow-up of chest CT can reflect the change process of NCIP and the treatment effect. | 2020-08-25 |
| 32838007 | As one of the important examination methods for the Corona Virus Disease 2019 (COVID-19), Computed Tomography (CT) examination plays an important role in the clinical discovery of suspected cases, diagnosis, and treatment review. […] This paper reviews the published papers in order to offer help in early clinical screening, disease diagnosis, disease severity determination and post-treatment review. | 2020-08-25 |
| 32838008 | After being discharged, the efficacy of treatment could be demonstrated by a follow up CT scan. […] CT scans in the whole course provided the entire inflammation information to assess clinical severity, disease progression and the treatment efficacy for COVID-19. | 2020-08-25 |
| 32838027 | Treatment options addressing COVID-19 included drug repurposing, investigational therapies such as remdesivir, and vaccine development. […] Combination therapy based on drug repurposing is among the most widely pursued of these efforts. […] Realizing synergistic combinations, however, is a substantially different outcome compared to globally optimizing combination therapy, which realizes the best possible treatment outcome by a set of candidate therapies and doses toward a disease indication. […] To address this challenge, the results of Project IDentif.AI (Identifying Infectious Disease Combination Therapy with Artificial Intelligence) are reported. | 2020-08-25 |
| 32838035 | The Polyphony programme is a rapidly established collaboration whose aim is to build and maintain a collection of current healthcare knowledge about detection, diagnosis and treatment of COVID-19 infections, and use Artificial Intelligence (knowledge engineering) techniques to apply the results in patient care. | 2020-08-25 |
| 32838040 | Of the deceased, only 6 patients (40%) were in active treatment. […] No specific treatment was established in 40 % (6/15) of the patients. | 2020-08-25 |
| 32838082 | Thirty-three (75%) patients required oxygen therapy, including 15 (45.5%) who were referred to the intensive care unit. | 2020-08-25 |
| 32838092 | This is a multi-centre collaborative audit of consecutive breast cancer patients undergoing treatment decisions during the acute and recovery phases of the COVID-19 pandemic. […] All patients with newly diagnosed primary breast cancer, whose treatment was decided in a multidisciplinary meeting from the 16th March 2020, are eligible for inclusion. | 2020-08-25 |
| 32838102 | Before the onset of SARS-CoV-2 infection, all patients were taking immunosuppressive therapy for AIH, and eight of them were on biochemical remission. […] In seven patients the dosage of immunosuppressive medication was changed. […] Patients under immunosuppressive therapy for AIH developing COVID-19 show a disease course presumptively similar to that reported in non-immunosuppressed population. | 2020-08-25 |
| 32838105 | Aggressive care should be maintained in SARS-CoV-2-positive patients with decompensated cirrhosis in order to overcome viral infection and to proceed as soon as possible with life-saving treatment. | 2020-08-25 |
| 32838109 | Prior phase I trials (non COVID-19) demonstrated improvement in pulmonary function in ARDS patients using fibrinolytic therapy. […] To describe the design and rationale of a Phase IIa trial to evaluate the safety and efficacy of alteplase treatment for moderate/severe COVID-19-induced ARDS. | 2020-08-25 |
| 32838111 | Physicians were queried about their current approach to prophylaxis, diagnosis, and treatment of VTE in patients with COVID-19 using an online survey tool distributed through multiple international organizations between April 10 and 14, 2020. 515 physicians responded from 41 countries. | 2020-08-25 |
| 32838116 | The ISSR recommendation is to postpone and reschedule in-laboratory positive pressure therapy, but it mentions the considerations to be followed in emergency situations. | 2020-08-25 |
| 32838131 | Frequent salbutamol inhalers were administered for treatment. | 2020-08-25 |
| 32838135 | The evidence-based knowledge of COVID-19 is rapidly evolving, and we hope that, in the near future, a definitive and most efficacious treatment will be available including a specific vaccine for SARS-CoV-2. | 2020-08-25 |
| 32838144 | We report here on benefits of CPAP treatment in a patient with COVID-19 pneumonia. […] Oxygen was administered at a rate of 15 litres per minute via a Boussignac valve, which initially restored normal oxygen saturation, but this treatment was poorly tolerated and the patient withdrew it after 2 h. | 2020-08-25 |
| 32838146 | A 58-year-old female with multiple sclerosis on fingolimod, chronic migraine well-controlled on fremanezumab, and cerebrovascular disease presented with fevers and respiratory symptoms, as well as acute treatment-refractory headache with associated neck stiffness and transient behavioral abnormalities. […] We offer anecdotal treatment recommendations for acutely refractory secondary headache and guidance for the consulting neurologist during the COVID-19 pandemic. | 2020-08-25 |
| 32838148 | Further studies on a large scale are urgently needed to explore the underlying mechanisms between CVD, DM, and COVID-19 for better treatment. | 2020-08-25 |
| 32838151 | In this short review, we have tried to address these queries in the simplest manner and compiled the history of previous coronaviruses, recent developments in the COVID-19 research, potential future therapeutics, and possible targets to cure the disease. | 2020-08-25 |
| 32838152 | Last but not least, this review examines potential pathophysiological mechanisms by the novel coronavirus which contribute to these haematological alterations aiding the clinicians to better understand this disease and provide more clinical treatment options. | 2020-08-25 |
| 32838157 | For these hospitalized patients with COVID-19, medication became the mainstay of therapy. […] It aims to review a 34-day period of pharmaceutical practice and serve as a reference for other health professionals working on COVID-19 prevention and treatment in other regions. | 2020-08-25 |
| 32838159 | To date, there is no definitive treatment for the new SARS-CoV-2 pandemic. […] There are 80 international experimental trials underway seeking effective treatment for the COVID-19 pandemic. […] Of these, there are only three that consider ozone therapy (major auto hemotherapy) as an alternative option. […] Ozone has four proven biological properties that could allow its use as an alternative therapy in the different phases of SARS-CoV-2 infection. […] Given the current pandemic, it is urgent to carry out an experimental study that confirms or rules out the biological properties of ozone and thus allows it to be an alternative or compassionate therapy for the effective management of SARS-Cov-2 infection. | 2020-08-25 |
| 32838163 | With no drugs currently approved for treatment and cure of COVID-19 (coronavirus disease 2019), hydroxychloroquine is one of the many first-line drugs used in the management. […] However, given the life-threatening adverse effects of HCQ that have been reported, its use as a prophylactic treatment remains debated. […] HCQ has long been used in India for the treatment of malaria, auto-immune and inflammatory diseases, and even type 2 diabetes mellitus recently. | 2020-08-25 |
| 32838164 | There is currently no specific and effective targeted treatment. | 2020-08-25 |
| 32838167 | The treatment of gynecological cancers is the main activity of brachytherapy units. […] More recently, the American Brachytherapy Society published some clarifications in this regard and international expert consensus recommendations of radiation therapy for gynecologic malignancies during the COVID-19 pandemic were published (https://www.americanbrachytherapy.org/about-abs/abs-news/abs-statement-on-coronavirus/, Gynecol Oncol 15, 2020). | 2020-08-25 |
| 32838169 | The following systematic review and meta-analysis compile the current data regarding human controlled COVID-19 treatment trials. […] An electronic search of the literature compiled studies pertaining to human controlled treatment trials with COVID-19. | 2020-08-25 |
| 32838170 | The objective of this review is to enhance the awareness regarding the safety aspects towards infection prevention practices and to offer solutions for safe patient care practices including side effects of disinfectants and precaution in specific medical facilities especially in hemodialysis rooms, intensive care unit, hyperbaric oxygen therapy (HBO) chambers, or patient transport vehicle. | 2020-08-25 |
| 32838174 | At the same time, dermatologists had to manage the skin injuries of frontline healthcare workers; to characterize the cutaneous manifestations of Covid-19; to assess the optimal treatment of patients with skin diseases, especially those taking immunomodulating and immunosuppressant molecules; and finally to promote balanced precautions in healthy persons. | 2020-08-25 |
| 32838178 | According to recent observations about different modalities in treatment of patients infected with COVID-19, plasmapheresis and intravenous immunoglobulin (IVIg) have been reported to be an effective empirical therapeutic option to control the infection. | 2020-08-25 |
| 32838181 | The treatment protocol consisted of 5 sessions (1 session/day) of intra-rectal ozone, applied in a volume of 100 mL and a concentration of 35 μg/mL. | 2020-08-25 |
| 32838182 | According to our research, colchicine may be an agent of interest in the treatment of COVID-19 via its anti-inflammatory properties. […] In this direction, our team proposes three different hypotheses for evaluating the place of colchicine in the treatment of COVID-19. | 2020-08-25 |
| 32838187 | During the spread of COVID-19, colleagues who have been working at the frontline have had to face many new challenges in the treatment and prevention of NCP. […] Therefore, we have provided suggestions for the diagnosis, treatment, and prevention of the novel coronavirus pneumonia in the current epidemic situation based on the latest reports and the experience of doctors treating COVID-19 in our hospital. […] We recommend lopinavir/ritonavir as the effective drugs for antiviral treatment according to our experience in administering lopinavir/ritonavir to COVID-19 patients and the successful cases of these drugs in treating MERS and SARS, but need more clinical data to prove their efficacy in treating COVID-19. | 2020-08-25 |
| 32838190 | In resource-scarce environments, in the light of the person-centered treatment paradigm, there is an immediate need to plan to meet the emerging challenge. | 2020-08-25 |
| 32838191 | Medical care aims are to ensure optimal treatment while minimizing the risk of COVID-19 transmission. | 2020-08-25 |
| 32838194 | The unexpected outbreak of COVID-19 in the area of Bergamo and the general crisis of personnel and devices has been managed as well as possible during the maximum peak of epidemic; Humanitas Gavazzeni Hospital implemented its facilities and organization in order to optimize the treatment of patients. | 2020-08-25 |
| 32838200 | Some suggested guidelines for emergency treatment of medical waste from COVID-19 have been provided by China. | 2020-08-25 |
| 32838206 | Meanwhile, the efficacy of emerging therapeutics for use in treating COVID-19 is feverishly being investigated to identify the best available treatment options for dealing with the current wave of disease. […] This review provides frontline clinicians with a pragmatic summary of the current state of the rapidly evolving evidence supporting emerging candidate therapeutics for COVID-19. […] Two main categories of pharmaceutical therapeutics are showing promise-those with antiviral activity directly addressing infection and those that counteract the inflammatory cytokine storm induced by severe disease. […] Preliminary results suggest that other approaches such as convalescent plasma therapy and lung radiation therapy may have some efficacy. | 2020-08-25 |
| 32838213 | To determine whether the frequencies of SARS-CoV-2-specific T cells are sufficiently high in the blood of convalescent donors and whether it is technically feasible to manufacture clinical-grade products overnight for T-cell therapy and assessment of COVID-19 immunity. […] The feasibility of clinical-grade production of SARS-CoV-2-specific T cells overnight for therapeutics and diagnostics is revealed. | 2020-08-25 |
| 32838219 | In many cases, this included implementation of telehealth programs for comprehensive medication management. | 2020-08-25 |
| 32838221 | They work with pharmacists at SPHCC, having responsibilities that include drug supplies, dispensing, pharmacy intravenous admixture services (PIVAS), prescription audits, medication reconciliations, pharmacotherapy, therapeutic drug monitoring, and patient education. […] Community pharmacies serve as the public access point to health care and medical supplies, providing services beyond dispensing and medication counselling. […] Pharmacists also participate in evaluating new treatments and keeping health care teams informed of new findings for potential treatment considerations. | 2020-08-25 |
| 32838223 | Thrombolytics are an alternative to percutaneous coronary intervention (PCI) allowing for timely treatment of patients and decreased staff exposure. | 2020-08-25 |
| 32838224 | The creation of guidelines, protocols, and restrictions were not only used to mitigate drug shortages, but also helped educate health care providers and guided medication use. […] Additional key pharmacist functions included provision of investigational drug service support and training of pharmacists, prescribers, nurses, and respiratory therapists to educate and standardize medication use. […] Through implementation of operational and clinical processes, pharmacists managed critical drug inventory and guided patient treatment. | 2020-08-25 |
| 32838232 | No adverse events were related to cell therapy. […] Two patients died (one due to massive gastrointestinal bleeding unrelated to MSC therapy). […] Treatment with AT-MSC was followed by a decrease in inflammatory parameters (reduction in C-reactive protein, IL-6, ferritin, LDH and d-dimer) as well as an increase in lymphocytes, particularly in those patients with clinical improvement. […] Treatment with intravenous administration of AT-MSC in 13 severe COVID-19 pneumonia under mechanical ventilation in a small case series did not induce significant adverse events and was followed by clinical and biological improvement in most subjects. | 2020-08-25 |
| 32838235 | An effective treatment aiming at reducing the inflammation without preventing virus clearance is thus urgently needed. […] Tocilizumab, an anti-soluble IL-6 receptor monoclonal antibody, has been proposed for treatment of patients with COVID-19. […] We compared survival rate and clinical status in a cohort of patients who received additional treatment with tocilizumab once (either 400 mg intravenous or 324 mg subcutaneous) with a retrospective cohort of patients who did not receive tocilizumab (referred to as the standard treatment group). […] All outcomes were assessed at the end of the follow-up, that correspond to death or complete recovery and discharge from the hospital. 158 patients were included, 90 of which received tocilizumab. 34 out of 68 (50%) patients in the standard treatment group and 7 out of 90 (7.7%) in the tocilizumab group died. […] Early treatment with tocilizumab could be helpful to prevent excessive hyper-inflammation and death in COVID-19 related pneumonia. | 2020-08-25 |
| 32838238 | Patients were assigned in a 1:2 ratio to receive either aerosol inhalation treatment with IFN-κ and TFF2, every 48 h for three consecutive dosages, in addition to standard treatment (experimental group), or standard treatment alone (control group). […] No treatment-associated severe adverse effects (SAE) were observed in the group treated with aerosol inhalation of IFN-κ plus TFF2, and no significant differences in the safety evaluations were observed between experimental and control groups. […] Aerosol inhalation of IFN-κ plus TFF2 is a safe treatment and is likely to significantly facilitate clinical improvement, including cough relief, CT imaging improvement, and viral RNA reversion, thereby achieves an early release from hospitalization. | 2020-08-25 |
| 32838244 | Patient characteristics, treatment strategies, and outcomes were determined. | 2020-08-25 |
| 32838264 | Treatment of coronavirus disease 2019 is mostly symptomatic, but a wide range of medications are under investigation against severe acute respiratory syndrome coronavirus 2. […] In life-threatening cases of coronavirus disease 2019, the potential risks of therapy to the fetus may be more than offset by the benefit of curing the mother. | 2020-08-25 |
| 32838282 | Therefore, the search for drug development targets and repositioning of existing therapeutics is essential for fighting the present pandemic. […] It was reviewed that therapeutics targeting SARS-CoV-2 binding to ACE2 receptor, viral RNA synthesis and replication, 3CLpro, RdRp, and helicase will play a crucial role in the development of treatment for SARS-CoV-2 infection. […] Remdesivir combination with chloroquine/hydroxychloroquine are promising drug repositioning for the treatment of COVID-19, and mRNA-1273 targeting spike protein is the promising vaccine. […] However, as patient management and drug repositioning are taking place, it is imperative to identify other promising targets used by SARS-CoV-2 to establish infection, to develop novel therapeutics. | 2020-08-25 |
| 32838283 | As the number of deaths due to COVID-19 is increasing rapidly and there is no specific treatment available to date, scientists are evaluating the effectiveness of already approved drugs as therapies against COVID-19, and the results were found to vary widely: from no significant effect being observed to a reduction in the time taken for clinical improvement. | 2020-08-25 |
| 32838292 | Increased awareness, early recognition of viral sepsis, rapid administration of appropriate antiviral drugs, and urgent treatment can significantly reduce deaths of viral sepsis. […] We analyzed complete laboratory examination, imaging data and treatment methods for the patients and assessed Sepsis-related Organ Failure Assessment score (SOFA score) and Multiple organ dysfunction scores (MOD score) daily, aimed to elucidate the clinical feature of viral sepsis and MODS and to attract enough attention by clinicians. […] We analyzed complete laboratory examination, imaging data and treatment methods for the patients and assessed Sepsis-related Organ Failure Assessment score (SOFA score) and Multiple organ dysfunction scores (MOD score) daily, aimed to elucidate the clinical feature of viral sepsis and MODS and to attract enough attention by clinicians. | 2020-08-25 |
| 32838293 | Considering Russell and colleagues’ [3] comments about potential harm of corticosteroid use in patients with COVID-19 infection, the patient was commenced on treatment with the selective IL-1 receptor antagonist drug, Anakinra, and a two-day course of intravenous immunoglobulin. […] The patient responded rapidly to treatment, becoming apyrexial after 24 h. […] We might suggest Anakinra to the scientific community as a treatment option in COVID-19 infection. | 2020-08-25 |
| 32838294 | Patients with elevated TnI had higher CURB-65 scores and were more likely given glucocorticoid therapy and mechanical ventilation than patients in normal TnI group. […] Patients with elevated TnI presented more severe situation, leading to multiple organ dysfunctions, which appeared as a pivotal feature of patients with NCIP that requires attention by clinicians in order to provide necessary treatment as soon as possible and improve patients’ outcomes. | 2020-08-25 |
| 32838299 | As study results of these combinations continue to be evaluated, there is a need to move beyond traditional drug screening and repurposing by harnessing artificial intelligence (AI) to optimize combination therapy design. […] This may lead to the rapid identification of regimens that mediate unexpected and markedly enhanced treatment outcomes. | 2020-08-25 |
| 32838302 | The COVID-19 pandemic has disrupted the spectrum of cancer care, including delaying diagnoses and treatment and halting clinical trials. | 2020-08-25 |
| 32838307 | We found no differences in rheumatological disease or background therapy between confirmed and suspected COVID-19 cases. 47 (72%) of the 65 patients with confirmed COVID-19 developed pneumonia that required admission to hospital. 12 (10%) deaths occurred among the 117 patients with confirmed or suspected COVID-19 (ten in those with confirmed COVID-19 and two in those with suspected COVID-19). | 2020-08-25 |
| 32838323 | Factors associated with receiving tocilizumab were patients’ age, gender, renal function, and treatment location. 630 patients were included in the propensity score-matched population, of whom 210 received tocilizumab and 420 did not receive tocilizumab. 358 (57%) of 630 patients died, 102 (49%) who received tocilizumab and 256 (61%) who did not receive tocilizumab. | 2020-08-25 |
| 32838343 | Surprisingly, we observe low overlap across screens while highlighting overlapping candidates that should receive more attention as potential therapeutics for COVID-19. | 2020-08-25 |
| 32838353 | This study successfully enrolled 86 patients with mild/moderate COVID-19, with 34 randomly assigned to receive LPV/r, 35 to arbidol, and 17 with no antiviral medication as control. | 2020-08-25 |
| 32838354 | Despite multiple public health measures,1, 2, 3 there remains an urgent need for pharmacologic therapies to treat infected patients, minimize mortality, and decrease pressures on intensive care units and health systems and optimally, they should also decrease subsequent transmission. | 2020-08-25 |
| 32838355 | Despite limited and conflicting evidence, hydroxychloroquine, alone or in combination with azithromycin, is widely used in COVID-19 therapy. […] Among patients hospitalized with COVID-19, this retrospective study did not identify any significant reduction in mortality or in the need for mechanical ventilation with hydroxychloroquine treatment with or without azithromycin. | 2020-08-25 |
| 32838362 | The ongoing coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is a global public health concern due to relatively easy person-to-person transmission and the current lack of effective antiviral therapy. | 2020-08-25 |
| 32838367 | This review summarizes the existing evidence for medications currently under investigation for treatment of COVID-19, including remdesivir, chloroquine/hydroxychlorquine, convalescent plasma, lopinavir/ritonavir, IL-6 inhibitors, corticosteroids, and angiotensin-converting enzyme inhibitors. | 2020-08-25 |
| 32838373 | High Velocity Nasal Insufflation (HVNI) and High Flow Nasal Cannula (HFNC) deliver High Flow Oxygen (HFO) therapy, established as a competent means of supporting oxygenation for acute respiratory distress patients, including that precipitated by COVID-19. […] Here, we present a subsequent high-resolution simulation (higher complexity/reliability) to provide a more accurate and precise particle characterization on the effect of surgical masks on patients during HVNI, Low-Flow Oxygen therapy (LFO2), and tidal breathing. | 2020-08-25 |
| 32838375 | This paper builds on previous work of ventilator allocation in pandemic crises to propose a literature-based, justice-informed ethical framework for selecting treatment options for CPR. | 2020-08-25 |
| 32838380 | Respiratory co-infections have the potential to affect the diagnosis and treatment of COVID-19 patients. | 2020-08-25 |
| 32838396 | All patients had undergone chest CT examination and blood routine tests prior to receiving medical treatment. | 2020-08-25 |
| 32838397 | Due to the lack of effective treatment options for COVID-19, various strategies are being tested. […] These results have implications for immunotherapy that could offer a novel therapy strategy for combating lethal viral pneumonia. | 2020-08-25 |
| 32838400 | A high percentage of smudge cells is associated with CLL diagnosis and has an important prognostic value: better survival and prolonged time to first treatment. | 2020-08-25 |
| 32838447 | In this article, the data available to date are examined in order to provide better information, advice and treatment for pregnant women and newborns with SARS-CoV-2 and to provide suggestions for future research. | 2020-08-25 |
| 32838472 | A thorough understanding of VWF-ADAMTS-13 interactions during early and advanced phases of COVID-19 could help better define the pathophysiology, guide thromboprophylaxis and treatment, and improve clinical prognosis. | 2020-08-25 |
| 32838716 | Food and Drug Administration (FDA), for the treatment of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2, previously known as 2019-nCoV) that causes COVID-19. | 2020-08-26 |
| 32838819 | Younger age (odds ratio = 1.05, 95 per cent confidence interval = 1.03-1.06) and the presence of anosmia (odds ratio = 2.04, 95 per cent confidence interval = 1.39-3) were significantly related to out-patient treatment. | 2020-08-26 |
| 32839022 | Heightened family stress and turmoil can increase risk for, and exacerbate, child maltreatment. […] As a result, child maltreatment experts are concerned that there will be an influx of children requiring trauma assessment and treatment during and after COVID-19. […] As physical distancing measures have been implemented and will likely persist into 2021, organizations providing trauma treatment to children and their families have had to rapidly pivot to telemental health to maintain service delivery with clients. […] While the benefits of telemental health have been identified, including reduced barriers to access, increased cost effectiveness, and broad availability of services, there are unique limitations to its implementation within a child maltreatment population, such as challenges with attention and emotion regulation skills, difficulties identifying dissociative symptoms, and increased time with perpetrators of abuse due to shelter in place orders. […] Lack of access to reliable technology, lack of a private or confidential space for sessions, and reluctance to process trauma in the absence of a safe environment, are all barriers to conducting effective trauma treatment over telemental health. […] This article discusses both the benefits and barriers to telemental health in a child maltreatment population and offers considerations for child trauma service provision, program development, and policy during and post the COVID-19 pandemic. | 2020-08-26 |
| 32839042 | The purpose of this study is to assess changes in STEMI volumes, door to reperfusion, and the time from the onset of symptoms until reperfusion therapy, and in-hospital events between the pre-COVID-19 (PC) and after COVID-19 (AC) period. […] During COVID-19 Pandemic the total STEMI volumes was reduced (28%, n = 500), STEMI volumes for those treated with reperfusion therapy was reduced too (27.6%, n= 450). | 2020-08-26 |
| 32839121 | Despite advances in treatment, patients with acute myocardial infarction (AMI) still exhibit unfavorable short- and long-term prognoses. | 2020-08-26 |
| 32839250 | As part of this study, we have also tested five filtration matrices for their effectiveness at removing the cytotoxic elements of each reagent, permitting accurate determination of levels of infectious virus remaining following treatment. | 2020-08-26 |
| 32839287 | For all patients, we suggest a holistic package of care to address breathlessness, anxiety, oxygen requirement, palliative care and rehabilitation. | 2020-08-26 |
| 32839385 | An electrocardiogram was taken on these patients within the first 48 h after diagnosis and before the administration of any medication with a known effect on QT interval. […] A prolonged QTc was independently associated with a higher mortality even after adjustment for age, comorbidities, and treatment with hydroxychloroquine and azithromycin. | 2020-08-26 |
| 32839624 | We propose that serum IL-6 and TNF-α levels should be considered in the management and treatment of patients with COVID-19 to stratify prospective clinical trials, guide resource allocation and inform therapeutic options. | 2020-08-26 |
| 32839635 | There is currently no specific antiviral drug for the treatment of this pandemic, with most treatment strategies focused on symptomatic management and supportive therapy. […] As such, several drug discovery efforts are ongoing for potent treatment agents, with medicinal plants gradually gaining prominence. | 2020-08-26 |
| 32839667 | A big portion of liver malignancies undergo palliative care. […] To this end, the paradigm of the palliative care in the liver cancer management is evolving from “just end of the life” care to careful evaluation of all aspects relevant for the survivorship. […] There were no significant differences in age, gender, therapy, diagnosis or comorbidities across clusters. […] In conclusion, multi-faceted cancer control within the palliative care of liver malignancies is crucial for improved disease outcomes including individualised patient profiling, predictive models and implementation of corresponding cost-effective risks mitigating measures detailed in the paper. | 2020-08-26 |
| 32839670 | This has resulted in restricted access of HCQ for COVID-19 treatment. | 2020-08-26 |
| 32839734 | It can also be a clinical decision assistance tool used to channel clinical-testing and treatment to those who need it the most, thereby saving more lives. | 2020-08-26 |
| 32839751 | The patient was affected by COVID-19, treated with supportive therapy. […] Special attention should therefore be paid to COVID-19 patients under anticoagulation with vitamin K antagonist and a shift to heparin treatment until illness resolution may be a safe option in these individuals. | 2020-08-26 |
| 32839867 | The clinical characteristics, underlying stroke mechanism, and outcomes in this particular subset of patients are especially salient as therapeutic anticoagulation becomes increasingly common in the treatment and prevention of thrombotic complications of COVID-19. | 2020-08-26 |
| 32839951 | The prioritized genes could be considered potential indicators of COVID-19-associated neurological symptoms and thus act as a possible therapeutic target for the prevention and treatment of CNS manifestations associated with COVID-19 patients. | 2020-08-26 |
| 32839960 | Improved therapeutics and a vaccine may shorten this period, but both are far from certain. | 2020-08-26 |
| 32840072 | Up to now, there was no specific antiviral drug, and we conjectured that immunomodulatory therapy might play an essential part in the treatment of coronavirus disease 2019 (COVID-19) as adjuvant therapy. […] Therefore, we analyzed the possible mechanism of immune imbalance caused by the new coronavirus, and summarized the immunotherapeutic means of COVID-19 based on the mechanisms, to provide some reference for follow-up research and clinical prevention and treatment of COVID-19. | 2020-08-26 |
| 32840148 | This article reports in detail the diagnosis and treatment process for two patients with confirmed COVID-19 and analyzes the results of the SARS-CoV-2 nucleic acid tests that were used for different types of specimens (sputum from deep cough, nasopharyngeal swab, and feces). | 2020-08-26 |
| 32840231 | Due to lack of any definitive medicine or vaccine, treatment options are supportive of oxygenation, antiviral, antiretroviral drugs, antibiotics, fluid/ electrolyte, mechanical ventilation with ICU (Intensive Care Unit) support, and chloroquine/hydroxychloroquine have been tried to fight this infection. […] However, mortality due to severe pneumonia, ARDS (Acute Respiratory Distress Syndrome), and multiorgan failure arising from the overactive immune response (storm) mediated by cytokines remains a treatment challenge in elderly and patients with severe medical comorbidities. | 2020-08-26 |
| 32840240 | CASE REPORT A 43-year-old man on anti-TB treatment for TB meningitis developed new-onset fever, fatigue, hypoxemic respiratory failure, and bilateral pulmonary opacities. | 2020-08-26 |
| 32840335 | In this setting, and also due to the absence of a specific treatment for the disease, health authorities had to opt for recommending or imposing social distancing to relieve the health system and reduce deaths. […] All other medical specialties non-directly related to the treatment of COVID-19 had to interrupt or strongly reduce their activities in order to give room to seriously ill patients, since no one knows so far the real extent of the virus damage on human body and the consequences of doing non deferrable procedures in this pandemic era. | 2020-08-26 |
| 32840399 | We retrospective summarized clinical characteristics of coronavirus disease 2019 (COVID-19) inpatients with hematological malignancies, shared treatment experiences, and analysis prognostic factors. […] During the epidemic, the pros and cons need to be carefully weighed while selecting the treatment methods. | 2020-08-26 |
| 32840560 | We have also covered the diagnosis, therapeutics and vaccine status of SARS-CoV-2. | 2020-08-26 |
| 32840571 | We reported two fatal cases of acute liver failure secondary to Herpes Simplex Virus 1 infection in COVID-19 patients, following tocilizumab and corticosteroid therapy.Screening for and prompt recognition of Herpes Simplex Virus 1 reactivation in these patients, undergoing immunomodulatory treatment, may have potentiallyrelevant clinical consequences. | 2020-08-26 |
| 32840579 | Limited is known about the characteristics of COVID-19 patients with end-stage renal disease not requiring renal replacement therapy (RRT). | 2020-08-26 |
| 32840614 | Pediatric infectious disease clinicians have a unique opportunity to advocate for the inclusion of children in epidemiological, clinical, treatment and prevention studies to optimize their care, as well as to represent children in the development of guidance and policy during pandemic response. | 2020-08-26 |
| 32840663 | The role of emergency medicine (EM) is to rapidly detect the virus, to classify disease severity, and to initiate therapy. […] Despite optimal intensive care treatment, the mortality of patients remains high if organ failure develops, especially in patients who are older or have pre-existing conditions. […] Intensive care is needed for the treatment of SARS-CoV-2-induced organ failure, whereby lung failure in these patients requires differentiated ventilation therapies. […] For early detection and appropriate treatment of SARS-CoV‑2 infection, PCR is needed. […] Adjunctive sonographic and radiological examinations allow the treatment of COVID-19 patients to be tailored according to the specific type of pneumonia. | 2020-08-26 |
| 32840686 | More than 70% of patients showed a good prognosis, mostly after treatment with intravenous immunoglobulin. | 2020-08-26 |
| 32840756 | Understanding both the general problems facing chronic pain patients as well as specific problems in the COVID-19 era including deconditioning, increased mental health concerns, financial burdens, and potential for medication-induced immune-suppression is vital in the appropriate management of patients. […] As a result, delaying, or stopping, treatment for chronic pain patients will have negative consequences, and strong pain evaluations must be administered to triage patients appropriately. | 2020-08-26 |
| 32840827 | Such an understanding means people should be helped to make morally right decisions about their own treatment, which may include forgoing potentially beneficial treatment for the good of others. […] Respect for dignity does not require fulfilling the morally wrong choices of one who insists on treatment at the expense of others. | 2020-08-26 |
| 32840836 | This paper will examine these impacts through a description of the influence on palliative care systems that have arisen within this pandemic. […] It will explore the impact on the meaning of care, how care is performed and identified, and the responses of palliative care systems to these challenges. | 2020-08-26 |
| 32841275 | We consider that these findings could contribute to improve the prognosis of patients with COVID-19 pneumonia, by initiating anticoagulant therapy when a PE is found. | 2020-08-26 |
| 32841311 | These efforts are uniquely challenging in the context of HIV-cure clinical trials, which often involve complex experimental therapy regimens and perhaps analytic treatment interruption (ATI), in which participants pause antiretroviral therapy (ART). | 2020-08-26 |
| 32841322 | In multivariable logistic regression models adjusted for sociodemographic, comorbidity, laboratory and medication data, there was a graded association between higher BMI levels and higher risk of COVID-19 infection; compared to normal weight individuals, the adjusted ORs in the overweight and obese individuals were 1.13 (95% CI, 1.03-1.25) and 1.26 (95% CI, 1.15-1.39), respectively. | 2020-08-26 |
| 32841329 | This article provides an overview of the underlying etiologies of innate immune system activation and adaptive immune system dysregulation in older adults and how they potentiate the consequences of the COVID-19 related cytokine storm, and possible uses of this knowledge to develop better risk assessment and treatment monitoring strategies. | 2020-08-26 |
| 32841342 | There have been several guidance statements focusing on the management of VTE in hospitalized and critically ill patients with COVID-19, including the most recent statement by the Scientific and Standardization Committee of the International Society of Thrombosis and Haemostasis, which includes comprehensive guidance on the diagnosis, prevention, and treatment of VTE in this patient population. | 2020-08-26 |
| 32841395 | This study aimed to assess (a) organizational preparedness of hospitals (establishment of screening clinics, COVID-19 wards/committees/intensive care units [ICUs]/operating rooms [ORs]), (b) type of major/minor surgeries performed, and (c) employee well-being (determined by salary deductions, paid leave provisions, and work in-rotation). | 2020-08-26 |
| 32841413 | One-hundred and fifty-nine patients with AN-discharged from inpatient treatment in 2019-completed an online survey on contact history with COVID-19, changes in ED symptoms and other psychological aspects, health care utilization, and strategies patients employed to cope during the pandemic. […] Videoconference therapy was used by 26% and telephone contacts by 35% of patients. | 2020-08-26 |
| 32841519 | Thus, alternative strategies, such as online measures to monitor this therapy and, consequently, to achieve a safe and effective dose are highly needed. | 2020-08-26 |
| 32841579 | Therefore, avoiding or mitigating the cytokine storm may be a key treatment for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). | 2020-08-26 |
| 32841599 | Most mutations are deleterious for RBD expression and ACE2 binding, and we identify constrained regions on the RBD’s surface that may be desirable targets for vaccines and antibody-based therapeutics. | 2020-08-26 |
| 32841626 | Veno-Venous Extracorporeal Membrane Oxygenation (VV-ECMO) is a rescue treatment for severe acute respiratory failure refractory to conventional ventilation. […] We examined the alterations of sublingual microcirculation in patients with SARS-CoV-2 during VV-ECMO treatment and assessed the relationship between microvascular parameters and ventilation, hemodynamics, and laboratory tests. | 2020-08-26 |
| 32841640 | As we enter the phase beyond limitations there is an urgent need for explicit treatment against COVID-19. […] Thus, drug repurposition is an attractive approach with reduced time and cost to treat COVID-19, we don’t have enough time as the whole world is lockdown and we are in urgent need of an obvious therapeutics’ measures. | 2020-08-26 |
| 32841654 | The purpose of this study was to evaluate the success of palliative care on endodontic emergencies during the COVID-19 pandemic and to evaluate the stability of teeth with long-term Ca(OH)2 placement because of delays in treatment completion. […] Patients presenting for endodontic emergencies during COVID-19 Shelter-in-Place orders received palliative care, including pharmacologic therapy and/or non-aerosol-generating procedural interventions. […] Part I of the study evaluated the effectiveness of palliative care, and need for aerosol-generating procedures or extractions was quantified. […] At a follow-up rate of 96%, 83% of endodontic emergencies required no further treatment or intervention after palliative care. […] Mean time to complete treatment was 13 weeks. […] At a recall rate of 100%, 77% of teeth did not experience any adverse events due to delays in treatment completion. […] The remaining 4 outcome failures (13%) were due to patient unwillingness to undergo school-mandated COVID testing or patient unwillingness to continue treatment because of perceived risk of COVID infection. […] Palliative care for management of endodontic emergencies is a successful option when aerosol-generating procedures are restricted. […] This treatment approach may be considered in an effort to reduce risk of transmission of COVID-19 infection during subsequent shutdowns. […] Prolonged Ca(OH)2 medicament because of COVID-19 related delays in treatment completion appeared to have minimal effect on survival of teeth. | 2020-08-26 |
| 32841659 | This review summarizes the various attempts that used GRP78 both in therapy (fighting cancer, viral and fungal infections) and diagnosis (imaging). | 2020-08-26 |
| 32841689 | This barcoding strategy will be required to monitor genetic diversity decrease as treatment and vaccine approaches become widely available. | 2020-08-26 |
| 32841704 | All treatment types reduced pathogen load by a log10 reduction factor of at least three when applied for sufficient duration (>30 s microwave, >60 min dry heat), with most studies assessing viral pathogens. […] Fit was maintained for most N95 models, though all treatment types caused observable physical damage to at least one model. | 2020-08-26 |
| 32841849 | Notably, SDB patients with good compliance to positive airway pressure therapy were less likely to report sleep difficulties. | 2020-08-26 |
| 32841919 | We compare and contrast COVID-19 hypercoagulability, and associated increased risk of venous and arterial thrombosis, from the perspective of heparin-induced thrombocytopenia (HIT), including the dilemma of providing thromboprophylaxis and treatment recommendations when available data are limited to observational studies. | 2020-08-26 |
| 32841929 | Wastewater-based epidemiology (WBE) has been used to analyze markers in wastewater treatment plant (WWTP) influent to characterize emerging chemicals, drug use patterns, or disease spread within communities. | 2020-08-26 |
| 32842256 | Results: In the present study, seven patients with acute STEMI received fibrinolysis therapy, 6 of them achieved reperfusion and no bleeding was observed in all of the patients. | 2020-08-26 |
| 32842491 | RNA interference (RNAi) provides the means for alternative antiviral therapy. […] In this review, examples of antiviral therapy applying RNAi-based approaches in various animal models will be described. | 2020-08-27 |
| 32842513 | There are limited proven therapeutic options for the prevention and treatment of COVID-19. | 2020-08-27 |
| 32842584 | Recent cancer-directed therapy was administered in 66.7% (n = 20) of ICU admissions versus 39.5% (n = 17) of general floor admissions (Chi-square p-value of 0.023). | 2020-08-27 |
| 32842622 | Some of these disorders are susceptible to a treatment, which is administered weekly or every other week, in a hospital. […] During the COVID-19 (Corona Virus Disease 2019) pandemic lockdown, patients with LSDs on enzyme replacement therapy (ERT) missed their scheduled access to the Day Hospital to get their treatment. | 2020-08-27 |
| 32842777 | In this essay, I describe the different ways touch was incorporated into my cancer treatment as well as wonder how touch in the clinical setting might remain changed as the result of COVID-19. […] More specifically, I narrate my clinical relationship with my oncology nurses and the role of instrumental and empathic touch over the course of six months of treatment and two years of follow-up. | 2020-08-27 |
| 32842818 | There is limited information on COVID-19, and treatment has so far focused on supportive care and use of repurposed drugs. | 2020-08-27 |
| 32842909 | While waiting for polymerase chain reaction (PCR) testing results, an accurate evaluation of the symptoms and serologic features can help us make a first diagnostic hypothesis and quickly start correct treatment. | 2020-08-27 |
| 32842957 | If inotropic therapy fails, TPE without protective antibodies may help rescue the critically ill patient. | 2020-08-27 |
| 32843064 | This result provides certain significant guidance for the diagnosis and treatment of new coronavirus pneumonia. | 2020-08-27 |
| 32843098 | The aim of this study is to explore the effectiveness and safety of high dose dexamethasone treatment for Acute Respiratory Distress Syndrome secondary to SARS-Cov-2 pneumonia. […] We will include patients with SARS-Cov-2 pneumonia who develop acute respiratory distress syndrome, in several intensive care units (ICU) in Buenos Aires, Argentina (CEMIC, Clinica Bazterrica, Sanatorio Sagrado Corazon) Inclusion criteria: Men and women, age ≥ 18 years old. […] Terminal disease (advanced cancer; under palliative care; cardiovascular, respiratory, or renal disease with a life expectancy less ≤ 1 year). […] Patients under chronic treatment with glucocorticoids for other diseases (≥ 8 mg prednisone, or equivalent) Participation in another randomized clinical trial. […] Treatment will be assigned according to site stratified randomization by permuted random blocks sequence 1:1 generated with a table in R language concealed in a randomization tool in REDCap (Research Electronic Data CAPture) platform. […] This is an open trial, so no masking of treatment assignment will be used. […] Assuming a 3 days difference in ventilator-free days between treatment groups, with a mean of 9 days, and a standard deviation of 9 days; the necessary sample size would be 284 subjects (142 per group), with a power of 80% and a two-tailed alpha error of 0.05. | 2020-08-27 |
| 32843231 | Inhibition of IL-1 by Anakinra (ANK) is a potential life-saving therapy for severe CSS cases. […] Resolution of ARDS within the first 7 days of treatment was considered a favorable outcome. […] Prior to treatment, median PaO2/FiO2 ratio of the ANK and TCZ cohorts were 193 and 249, respectively (p = 0.131). […] After 7 days of treatment, PaO2/FiO2 ratio improved in both groups to 279 (104-335) and 331 (140-476, p = 0.099) respectively. […] Two patients that failed to respond to TCZ improved after ANK treatment. […] There were not any opportunistic infection in the groups nor other adverse effects attributable to treatment. | 2020-08-27 |
| 32843234 | The Chinese government proposes that both Traditional Chinese medicine (TCM) and Western medicine can be used in combination to treat pneumonia caused by SARS-CoV2, and TCM effectively provides continuous prevention and treatment. […] The present review analyzes and summarizes the prevention and treatment of the novel coronavirus disease (COVID-19) with TCM. […] A classified analysis of the efficacy and advantages of TCM for the prevention and treatment of COVID-19 was performed, and the mechanisms of TCM in treating COVID-19 are summarized. […] Only approximately 10,000 patients are currently being treated, and the total treatment time is approximately 2 months. […] TCM is currently the best choice for the treatment and prevention of COVID-19, and it is expected that it will be promoted by countries around the world. | 2020-08-27 |
| 32843326 | We describe the measures taken by West China Hospital of Sichuan University to address the diagnosis, prevention and treatment of the infection. | 2020-08-27 |
| 32843381 | The patient died 5 days following admission under the palliative care provided by the medical team. | 2020-08-27 |
| 32843441 | These patients had highly unusual but similar features, and both appeared to respond favorably to treatment. | 2020-08-27 |
| 32843467 | Treatment with corticosteroids resulted in rapid clinical resolution. | 2020-08-27 |
| 32843534 | While the best interventions to control and ultimately stop the pandemic are prophylactic vaccines, antiviral therapeutics are important to limit morbidity and mortality in those already infected. […] With respect to drug targets, most attention is focused on either the viral RNA-dependent RNA polymerase or the main viral protease, 3CLpro 3CLpro is an attractive target for antiviral therapeutics as it is essential for processing newly translated viral proteins, and the viral lifecycle cannot be completed without protease activity. | 2020-08-27 |
| 32843598 | As COVID-19 is a “new” disease, we still do not have data on prognosis or treatment in transplant patients or on how to manage immunosuppression in this complex scenario. | 2020-08-27 |
| 32843771 | We illustrate this approach in an outpatient program of dialectical behavioral therapy for patients with borderline personality disorder. | 2020-08-27 |
| 32843866 | The aim of this study is to retreive published papers about COVID-19 infection deposited in PubMed data base and analyzed current results of investigations regarding morbidity and mortality rates as consequences of COVID-19 infection and opinions of experts about treatment of afected patients with COVID-19 who have Cardiovascular diseases (CVDs). […] Vaccine against COVID-19 is already produced and being in phases of testing in praxis in treatment of COVID-19 at affected patients, but the opinions of experts and common people whole over the world about vaccination are full of controversis. […] Authors analyzed most important dilemmas about all aspects of CVDs, including etipathogenesis, treatment with current drugs and use of potential discovered vaccines against COVID-19 infection, described in scientific papers deposited in PubMed data base. | 2020-08-27 |
| 32844112 | A significant proportion of patients who require intubation succumb to the disease, despite the availability of ventilators and the best treatment practices. […] Low-level laser therapy (LLLT) has strong, anti-inflammatory effects confirmed by meta-analyses, and it may be therapeutic to ARDS. […] LLLT is a safe, effective, low-cost modality without any side-effects that may be combined with conventional treatment of ARDS. […] We summarize the effects of LLLT on pulmonary inflammation and we provide a protocol for augmenting medical treatment in COVID-19 patients. […] LLLT combined with conventional medical therapy has the potential to prevent the progression of COVID-19, minimize the length of time needed on a ventilator, enhance the healing process, and shorten recovery time. | 2020-08-27 |
| 32844113 | Helmet NIPPV is a feasible therapy to manage COVID-19 patients. | 2020-08-27 |
| 32844126 | This insight can lead the way to further research and treatment. | 2020-08-27 |
| 32844131 | We recommend anticoagulant therapy and early rehabilitation intervention to prevent pulmonary embolism in COVID-19 patients. | 2020-08-27 |
| 32844132 | Metformin is one of the drugs which is most commonly used for the treatment of diabetes patients. | 2020-08-27 |
| 32844172 | Therefore, in the current pandemic, providing a fast-track algorithm for scientifically standardized diagnostic criteria and treatment recommendations for patients with lung cancer is urgent. | 2020-08-27 |
| 32844224 | No data are available regarding the toxicity of this treatment in haemodialysis patients. […] No cardiac event occurred in spite of progressive lengthening of corrected QT interval (QTc) during the treatment. […] We recommend monitoring of the QTc length throughout treatment, as well as glycaemia. | 2020-08-27 |
| 32844290 | We investigated incidence and treatment of AKI in pediatric patients with COVID-19 in Wuhan Children’s Hospital during the early stages of the COVID-19 pandemic and discuss possible mechanisms of AKI related to SARS-CoV-2 infection. […] The three patients with AKI were treated with plasma exchange (PE) and continuous kidney replacement therapy (CKRT), resulting in one complete recovery, one partial recovery, and one mortality due to critical illness. | 2020-08-27 |
| 32844364 | Chest computed tomography scans before the antiviral therapy showed bilateral multiple patchy ground-glass opacities (GGO) consistent with COVID-19 pneumonia. […] The GGO regressed over the course of the antiviral treatment; however, new non-segmental patchy consolidations emerged, which resembled those of interstitial lung disease (ILD), specifically collagen vascular disease-associated ILD. […] In Case 1, the patient recovered with antiviral therapy alone. […] However, in Case 2, the patient did not improve with antiviral therapy alone but responded well to corticosteroid therapy (methylprednisolone) and made a full recovery. | 2020-08-27 |
| 32844546 | National data on patient characteristics, treatment, and outcomes of critically ill coronavirus disease 2019 (COVID-19) solid organ transplant (SOT) patients are limited. […] We analyzed data from a multicenter cohort study of adults with laboratory-confirmed COVID-19 admitted to intensive care units (ICUs) at 68 hospitals across the United States from March 4 to May 8, 2020. […] There was a trend toward higher risk of acute kidney injury requiring renal replacement therapy in SOT vs. non-SOT patients (37% vs. | 2020-08-27 |
| 32844821 | The 2 completed RCTs showed significantly better treatment effects on disease progression, viral clearance, improved the latency to relief for pyrexia and cough on favipiravir treated patients. […] Although 9 more RCTs and cohort studies are supposed to be completed by this time that may unveil some evidence for use of anti-RNA-viral drug favipiravir against influenza or Ebola to re-purposing against COVID-19 as adopted in different treatment guidelines. | 2020-08-27 |
| 32844958 | Similarly, the frequencies of oxygen therapy (100% vs. 33%, p=0.003), intravenous immunoglobulin therapy (67% vs. 2%, p<0.001), aspirin therapy (50% vs. 0%, p<0.001), and current acute renal replacement therapy (50% vs. 2%, p=0.002) were also significantly higher in patients with MIS-C. | 2020-08-27 |
| 32845030 | We address both the challenges posed by the pandemic and the organizational model established in Spain; changes in ECMO therapy and some lessons learned for the next outbreaks are also described. | 2020-08-27 |
| 32845145 | In this article, Chinese therapy strategies for treating COVID-19 patients, including current applications of traditional Chinese medicine (TCM), are comprehensively reviewed. | 2020-08-27 |
| 32845280 | Onset clinical symptoms and duration, ocular symptoms, and needs for medication. | 2020-08-27 |
| 32845384 | The initial phase of the pandemic was characterized by a massive reduction in non-urgent conservative and surgical treatment that affected all areas of ophthalmology. […] Due to intensive care capacities required for COVID-19 patients, inpatient treatment was largely restricted to emergencies. […] Treatment of ophthalmological patients, including ocular emergencies and urgent treatment, was maintained across all sectors with a (considerable) decrease in the number of cases even in these groups. | 2020-08-27 |
| 32845538 | However, evidence from large population-based studies examining whether cancer and cancer-related therapy exacerbates the risk of COVID-19 infection is still limited. […] Among patients with cancer, current treatment with chemotherapy or immunotherapy was associated with a 2.2-fold increased risk of a positive test. […] Future studies are needed to identify subgroups by tumor types and treatment regimens who are particularly at risk for COVID-19 infection and adverse outcomes. | 2020-08-27 |
| 32845568 | Inhibition of IL-6 may be a novel target for therapeutics for the management of dysregulated host responses in patients with Covid-19 and high-quality studies of intervention in this field are urgently required. | 2020-08-27 |
| 32845733 | Since immunotherapy has been implicated for COVID-19 treatment and vaccine is under development, due consideration has to be provided on ADE to prevent untoward reactions. | 2020-08-27 |
| 32845739 | Since there is still no effective treatment or vaccine, non-pharmaceutical interventions have been implemented in an attempt to contain the spread of the virus. | 2020-08-27 |
| 32845742 | Given the significant threats of COVID-19, the global organizations are racing to identify epidemiological and pathogenic mechanisms of COVID-19 to find treatment regimens and effective therapeutic modalities for future prevention. | 2020-08-27 |
| 32845750 | At present, there is no specific treatment for COVID-19 in adults or children; management is usually supportive. […] For severe or critical disease, including paediatric multisystem inflammatory syndrome temporally associated with COVID-19, the decision to start antiviral or immunomodulatory therapy should be on a case-by-case basis; in the UK, this should be done within a clinical trial. […] Further research is needed into both the disease course and treatment of paediatric COVID-19. | 2020-08-27 |
| 32845869 | Until now, there is no effective pharmaceutical treatment; conclusively it is important to evaluate the types of applied disinfectants in different areas against Severe Acute Respiratory Syndrome Corona Virus 2 (SARS-CoV-2), the virus that causes COVID-19. | 2020-08-27 |
| 32845926 | Tailored infection prevention and treatment strategies targeting this high-risk population might improve survival. | 2020-08-27 |
| 32845937 | Several NK cell therapeutic options already exist in the treatment of tumor and other viral diseases and could be repurposed against COVID-19. […] In this review, we describe the current understanding and potential roles of NK cells and other Fc receptor (FcR) effector cells in SARS-CoV-2 infection, advantages of using animals to model COVID-19, and NK cell-based therapeutics that are being investigated for COVID-19 therapy. | 2020-08-27 |
| 32846164 | COVID-19, an infectious disease caused by a novel corona virus and no approved specific treatment is available yet. […] The prospective treatment options integrating the ever-expanding field of nanotechnology have been compiled, with the objective to show that these can be potentially developed for COVID-19 treatment. | 2020-08-27 |
| 32846165 | Clinicians should be vigilant to this kind of COVID-19-associated diarrhea, and design more effective prevention and treatment options for patients with positive fecal nucleic acid tests and intestinal microflora disorders. | 2020-08-27 |
| 32846167 | Considering the existing research on COVID-19 and related to D-xylose/xylitol, this review offers a perspective on why the association between D-xylose and antibiotics may contribute to significantly reducing the duration of treatment of COVID-19 patients and why some anti-inflammatory drugs may increase the severity of COVID-19. […] Related to this, the effects of treatment with plants such as Artemisia are also addressed. | 2020-08-27 |
| 32846177 | The pathogenesis of novel virulent pathogens at the cellular and molecular levels are also considered, which is of utmost importance to characterize the emerging nano-drug agents as diagnostics or therapeutics or viral entry inhibitors. […] Such types of approaches trigger the scientists and policymakers in the development of a conceptual framework of nano-biotechnology by linking nanoscience and virology to present a smart molecular diagnosis/treatment for pandemic viral infections. | 2020-08-27 |
| 32846196 | Since SARS-CoV-2 uses the spike (S) protein for entry to the host cell, it is one of the most preferred targets for making vaccines or therapeutics against SARS-CoV-2. […] In this review, we have summarised the characteristics of the S protein, as well as the different approaches being used for the development of vaccines and/or therapeutics based on the S protein. | 2020-08-27 |
| 32846329 | Collectively, we proposed that entecavir and imipenem might be candidates for the treatment of CSS. | 2020-08-27 |
| 32846427 | These findings provide a possible explanation for the observed sex biases in COVID-19, and provide an important basis for the development of a sex-based approach to the treatment and care of male and female patients with COVID-19. | 2020-08-27 |
| 32846825 | The clinical and epidemiological characteristics, data of laboratory, radiological picture, treatment, and outcomes records of 201 COVID-19 patients were collected using electronic medical records. | 2020-08-28 |
| 32846842 | Fire needle is used as an alternative therapy. […] At present, there are no relevant articles for systematic review and meta-analysis, so this study will evaluate the efficacy and safety of fire needle in the treatment of COVID-19 pneumonia. […] This study will investigate the application of fire needle in the treatment or prevention of COVID-19, and provide a high-quality synthesis to evaluate whether fire needle is an effective and safe intervention for COVID-19. | 2020-08-28 |
| 32846843 | COVID-19 has no vaccine or specific therapy; its mortality rate increases significantly once patients deteriorate. […] The research is designed as a prospective cohort study, to verify a dynamic and interactive evaluation system; it includes patient self-reporting, active monitoring, early alarming and treatment recommendations. […] The intervention is implementation of EWRRS to detect early signs of clinical deterioration of COVID-19 patients, to provide timely and efficient treatment suggestions by the system. […] The primary outcome is change in disease severity category after treatment. | 2020-08-28 |
| 32846906 | In this review, we discussed high-performance multi-directory strategies describing the uncontrolled deregulation of the host immune landscape associated with coronavirus disease (COVID-19) and treatment strategies using an anti-neoplastic regimen. […] We also followed selected current treatment plans and the most important on-going clinical trials and their respective outcomes for blocking SARS-CoV-2 pathogenesis through regenerative medicine, such as stem cell therapy, chimeric antigen receptors, natural killer (NK) cells, extracellular vesicular-based therapy, and others including immunomodulatory regimens, anti-neoplastic therapy, and current clinical vaccine therapy. | 2020-08-28 |
| 32847008 | Therefore, many efforts are currently being developed to improve therapy and diagnosis, as well as to produce inhibitory drugs and biosensors for a rapid, minimally invasive, and effective detection. | 2020-08-28 |
| 32847033 | As melatonin shows no harmful adverse effects in humans, it is imperative to introduce this indoleamine into clinical trials where it might be beneficial for better clinical outcomes as an adjuvant treatment of COVID-19-infected patients. […] This is urgent, since there is no reliable treatment for this devastating disease. | 2020-08-28 |
| 32847368 | With increasing effectiveness of antiretroviral therapy, people with HIV (PWH) are living longer and the prevalence of older PWH continues to increase. | 2020-08-28 |
| 32847486 | We illustrate three possible approaches through which mental health science may stimulate thinking around psychological treatment innovation. […] Second, investigating mechanisms that can be modified in treatment (treatment mechanisms), rather than those which cannot (e.g., processes only linked to aetiology). […] Finally, exploring novel ways of delivering psychological treatment (peer-/self-administration), given the prevalence of mental health problems globally, and the corresponding need for effective interventions that can be delivered at scale and remotely for example at times of crisis (e.g., current COVID-19 pandemic). […] These three approaches suggest options for potential innovative avenues through which mental health science may be harnessed to recouple basic and applied research and transform treatment development. | 2020-08-28 |
| 32847559 | We hope to avoid the spread of NCP while ensuring efficient treatment of emergency cases. | 2020-08-28 |
| 32847594 | While physicians and scientists have yet to discover a treatment, it is imperative that we urgently address 2 questions: how to prevent infection in immunologically naive individuals and how to treat severe symptoms such as CRS, acute respiratory failure, and the loss of somatosensation. […] According to our literature search, there are no similar findings of clinical trials that have been published as of July 1st, 2020, in relation to the supplementation of vitamin D in the potential prevention and treatment for COVID-19. […] In this review, we summarize the potential role of vitamin D extra-renal metabolism in the prevention and treatment of the SARS-CoV-2 infection, helping to bring us slightly closer to fulfilling that goal. | 2020-08-28 |
| 32847626 | Withdrawal from active therapy; Pregnancy (non-pregnancy confirmed by patient being postmenopausal (age 60 or above) or having a negative urine- or plasma-hCG); Known hypersensitivity to iloprost or to any of the other ingredients; Previously included in this trial or a prostacyclin trial within 30 days; Consent cannot be obtained; Life-threatening bleeding defined by the treating physician; Known severe heart failure (NYHA class IV); Suspected acute coronary syndrome The study is conducted at five intensive care units in the Capital Region of Denmark at Rigshospitalet, Herlev Hospital, Hvidovre Hospital, Bispebjerg Hospital, Nordsjællands Hospital. […] Primary endpoint: Days alive without mechanical ventilation in the intensive care units within 28 days RANDOMISATION: The randomisation sequence is performed in permuted blocks of variable sizes stratified for trial site using centralised, concealed allocation. | 2020-08-28 |
| 32847728 | Glucocorticoids were most commonly used in treatment of myocarditis (58%). […] In our review, there appears to be favorable outcomes related to myocarditis treated with steroid therapy. […] However, until larger scale studies are conducted, treatment approaches have to be made on an individualized case-by-case basis. | 2020-08-28 |
| 32847748 | Symptomatic neonates born to infected mothers should receive tests for SARS-CoV-2 to initiate appropriate treatment and quarantine. | 2020-08-28 |
| 32847947 | Alternative therapy of high flow nasal therapy (HFNT) has been greatly debated around the world for use in COVID-19 pandemic due to concern for increased healthcare worker transmission.This was a retrospective analysis of consecutive patients admitted to Temple University Hospital in Philadelphia, Pennsylvania, from 10 March 2020 to 24 April 2020 with moderate-to-severe respiratory failure treated with HFNT. | 2020-08-28 |
| 32847961 | A review of the literature yields descriptive studies in pediatric patients; however, no evidence-based or evidence-informed guidelines for the diagnosis and treatment of the hospitalized pediatric patient have been published in peer-reviewed journals. | 2020-08-28 |
| 32848011 | The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) outbreak urgently necessitates sensitive and convenient COVID-19 diagnostics for the containment and timely treatment of patients. | 2020-08-28 |
| 32848162 | Therefore, special consideration should be given to these stable interactions while designing potential drugs and treatment modalities to target or disrupt this interface. | 2020-08-28 |
| 32848272 | It has been proposed that patients on angiotensin-converting enzyme inhibitor (ACE-I) and angiotensin receptor blockers (ARB) therapy infected with SARS-CoV-2 have a higher mortality rate due to over-expression of ACE-2 receptors. […] The rate of invasive mechanical ventilation (p=0.007) and 90-day mortality (p=0.045) among HCoV-NL63 positives on ACE-I therapy was higher compared to those HCoV-NL63 positives not on ACE-I therapy. […] Concurrent therapy with an ACE-I was associated with an increased rate and severity of infection with the HCoV-NL63. […] This association was not found in infected patients on concurrent ARB therapy. | 2020-08-28 |
| 32848431 | This review provides an overview about the COVID-19 virus to increase public awareness and understanding of the virus and its consequences in terms of history, epidemiology, structure, genome, clinical symptoms, diagnosis, prevention, and treatment. | 2020-08-28 |
| 32848446 | In this article, we have reviewed the prevalence, diagnosis, symptoms, and treatment of COVID-19 in children. […] Antiviral medication (lopinavir, darunavir, favipiravir, remdesivir, ribavirin, oseltamivir, tocilizumab, and umifenovir), ACE inhibitors, interferon-α2b, co-therapy with azithromycin, inhaling iNO, and oxygen therapy can be used for treatment. […] For the treatment of children without any clinical and infection symptoms, home isolation protocol has been recommended. | 2020-08-28 |
| 32848487 | The result categorized into two distinct clinical areas: treatment (18 articles) and diagnostic (23 articles) services. | 2020-08-28 |
| 32848729 | Coronavirus Disease 2019 (COVID-19) is an emerging and rapidly evolving disease, with no recommended effective anti-coronavirus drug treatment. […] Traditional Chinese Patent Medicines (CPMs) have, however, been widely used to treat COVID-19 in China, and a number of clinical practice results have shown them to have a significant role in its treatment. […] The objectives of this review are to provide up-to-date information on the pharmacology and clinical research on CPMs in the treatment of COVID-19, discuss the research findings, and to better guide clinical application and scientific research on CPMs in the treatment of COVID-19. […] The frequencies of CPM recommendations by guidelines and expert consensus for treatment of COVID-19 in China were ranked. […] In addition, clinical research results and Chinese treatment data showed that the CPMs had good therapeutic efficacy in the treatment of COVID-19, and adverse reactions were minimal. | 2020-08-28 |
| 32848743 | Clinical, laboratory and treatment data were collected and analyzed. […] Out of 450 patients, 361 received standard deep vein thrombosis (DVT) prophylaxis enoxaparin treatment (40-60mg daily) and 89 patients received intermediate enoxaparin dosage (40-60 mg twice daily) for 7 days. […] Our study paves the way to further pathophysiological investigations and controlled studies of anticoagulation therapy in Covid-19 disease. | 2020-08-28 |
| 32848774 | This review summarizes the latest clinical trials of CQ and HCQ against COVID-19 and its therapeutic regimen in China aiming to share their current usage to the whole world and provide insight into its appropriate future use in the treatment of COVID-19. | 2020-08-28 |
| 32848788 | Dipeptidyl peptidase-4 inhibitors exert beneficial effects in prevention/treatment of pulmonary fibrosis, heart, and kidney injury, and since they may be a long-term consequence caused by COVID-19, it is reasonable to expect that DPP-4 inhibitors might be beneficial in alleviating long-term consequences of COVID-19. | 2020-08-28 |
| 32848795 | Preclinical and clinical studies of potential antiviral and immunomodulatory compounds and molecules to identify safe and efficacious therapeutics for COVID-19 are ongoing. […] Here, we provide a review of the potential therapeutic agents being considered for the treatment and management of COVID-19 patients. | 2020-08-28 |
| 32848802 | As a new virus, not previously in the human population, but with similarities to other coronaviruses causing severe acute respiratory distress syndrome (SARS/ARDS), and no known treatments, the race to re-purpose existing drugs and to enlist novel therapeutics is underway. […] We offer a simple treatment paradigm using two generic drugs targeting the hyperinflammatory response that characterizes the turning point from mild to severe/critical COVID-19 by targeting leukotriene biosynthesis with zileuton (Zyflo® controlled release formulation) and antagonism of the cysteinyl leukotriene 1 receptor with montelukast (Singulair®). | 2020-08-28 |
| 32848845 | Hypothesis: In the present paper, we present and justify a novel potential treatment for Covid19-originated ARDS and associated co-morbidities, based on the non-invasive stimulation of the auricular branch of the vagus nerve. […] Results: Along the paper (1) we expose the role of the parasympathetic system and the vagus nerve in the control of inflammatory processes (2) we formulate our physiological and methodological hypotheses (3) we provide a large body of clinical and preclinical data that support the favorable effects of auricular vagus nerve stimulation in inflammation, sympatho-vagal balance as well as in respiratory and cardiac ailments, and (4) we list the (few) possible collateral effects of the treatment. […] Conclusions: Auricular vagus nerve stimulation is a safe clinical procedure and it could be either an effective treatment for ARDS originated by Covid-19 and similar viruses or a supplementary treatment to actual ARDS therapeutic approaches. | 2020-08-28 |
| 32849083 | The HCWs have sufficient information about the COVID-19 symptoms, prognosis, treatment, infection route, and preventive measures (medians ranged from 6/9 to 8/9). | 2020-08-28 |
| 32849309 | Taken together, it may be crucial to better explore the role of visceral adipose tissue in the inflammatory response to SARS-CoV-2 infection and investigate the potential therapeutic effect of using specific target anti-inflammatories (canakinumab or anakinra for IL-1β inhibition; anti-IL-6 antibodies for IL-6 inhibition), anticoagulant or anti-diabetic drugs in COVID-19 treatment of people with obesity. | 2020-08-28 |
| 32849425 | We also hint how lipid rafts and autophagy may represent a potential therapeutic target to be investigated for the treatment of coronavirus infections. | 2020-08-28 |
| 32849449 | Due to the novel nature of this virus, there is an urgent need for vaccines and therapeutics to control the spread of SARS-CoV-2 and its associated disease, COVID-19. […] In the absence of any effective therapeutics, we have devised h bioinformatics-based approaches to accelerate global efforts in the fight against SARS-CoV-2 and to assist researchers in the initial phase of vaccine and therapeutics development. […] The resource is categorized into the main sections “Genomes,” “Epitopes,” “Therapeutics,” and Primers." […] The therapeutics section has different sub-sections like siRNA, miRNAs, and sgRNAs. | 2020-08-28 |
| 32849643 | In this study, with the aid of immunoinformatics tools, we tried to design a multi-epitope vaccine that can be used for the prevention and treatment of COVID-19. | 2020-08-28 |
| 32849647 | Passive immunity by immunoglobulin transfer is a concept employed by most mammals and bovine IgG has a role to play in human therapy. | 2020-08-28 |
| 32849654 | As there are no specific treatments available for this novel coronavirus, numerous small molecular drugs that are being used for the treatment of diseases like SARS, MERS, HIV, ebola, malaria, and tuberculosis are being given to COVID-19 patients, and clinical trials for many such drugs have already begun. […] This review highlights the similarities of the coronaviruses that caused SARS and MERS to the novel SARS-CoV-2 in relation to their pathogenicity and immunogenicity and also focuses on various treatment strategies that could be employed for curing COVID-19. | 2020-08-28 |
| 32849658 | Recent small-scale clinical trials have shown promising results in the use of hydroxychloroquine, an FDA approved anti-malaria drug, for the treatment of COVID-19. […] Here, we review the progress of using hydroxychloroquine or chloroquine as anti-viral agents, failed clinical trials of chloroquine in treatment of dengue virus and influenza infection, and especially the mechanism of azithromycin in inhibiting viral replication, so as to shed light on the ongoing clinical trials and further researches of hydroxychloroquine on SARS-CoV-2 infected patients. | 2020-08-28 |
| 32849666 | Therapies targeting the CS, the KKS and action of BK could be effective for the treatment of COVID-19. | 2020-08-28 |
| 32849913 | With regard to the prevention and treatment strategy for urinary stones during this COVID-19 pandemic period, patients can be divided into two groups. […] However, we suggest conservative treatment for 3 months during the COVID-19 outbreak after which re-evaluation of the patient should be carried out. | 2020-08-28 |
| 32849934 | Despite high morbidity and mortality of ongoing coronavirus disease 2019 (COVID-19) pandemic, no specific therapy has been established till date. | 2020-08-28 |
| 32849936 | The response to therapy assessed by negative repeat polymerase chain reaction (PCR) (OR: 1.83, 95% CI: 0.50 - 6.75, P = 0.36), radiological resolution (OR: 1.98, 95% CI: 0.47 - 8.36, P value = 0.36) and the need for invasive mechanical ventilation (IMV) (OR: 1.21, 95% CI: 0.34 - 4.33, P value = 0.76) were identical between the two groups. | 2020-08-28 |
| 32849949 | HCQ + MOX combination therapy led to increases in QTc interval, Tp-e interval, and cTp-e interval. […] However, this therapy did not cause ventricular arrhythmia in the short-term observation. | 2020-08-28 |
| 32850016 | Herein we present a 26-year-old woman with a twin pregnancy at 36 wk and one day gestation with confirmed COVID-19 who responded dramatically to convalescent plasma therapy (CPT) and Favipiravir. […] Although this case report shows the efficacy of CPT in addition to usual medications used for COVID-19, there are many questions that need to be answered regarding dosage, para-clinical efficacy, side effects and combination therapy. | 2020-08-28 |
| 32850041 | We here describe our experiences during the treatment of COVID-19 patients (n = 42) treated from 2 March 2020 to 16 April 2020 at a German district hospital. | 2020-08-28 |
| 32850082 | Despite initiation of hydroxychloroquine and azithromycin along with supplemental oxygen therapy, rapid disease progression consistent with cytokine release syndrome ensued, leading to initiation of mechanical ventilatory support. | 2020-08-28 |
| 32850107 | Currently, little is known about whether patients with PD are more susceptible to novel coronavirus disease 2019 (COVID-19) and whether the treatment of PD would affect the management of COVID-19 or vice versa. […] In addition to treatment for COVID-19 and urinary tract infection, we adjusted anti-PD medicine by stepwise increasing of dose, resulting in better control of her mobility symptoms and non-motor symptoms. | 2020-08-28 |
| 32850133 | We consider whether altered dynamics of peripheral immune cells in the context of natalizumab treatment could worsen the cytokine storm syndrome associated with severe COVID-19. | 2020-08-28 |
| 32850149 | Critical care medicine is a branch of medical science that deals with the characteristics and regularity of life-threatening processes initiated by any injury or disease and, accordingly, relevant treatment for patients with critical illness. | 2020-08-28 |
| 32850151 | With no proven effective targeted therapy against pulmonary fibrosis, risk reduction measures should be directed at limiting the severity of the disease and protecting the lungs from other incidental injuries. | 2020-08-28 |
| 32850160 | Here, we highlight the prognosis, discuss the pathophysiological mechanisms, and prompt the consideration of convalescent plasma therapy in myasthenia gravis patients with concomitant COVID-19. | 2020-08-28 |
| 32850163 | Guidelines for treatment of ES are not well-defined. | 2020-08-28 |
| 32850198 | He had a history of idiopathic pulmonary fibrosis (IPF) and was undergoing treatment with antifibrotic medication. | 2020-08-28 |
| 32850199 | It is important to know and report new findings of novel diseases not only for diagnosis and treatment but also to place appropriate isolation precautions and containment. | 2020-08-28 |
| 32850225 | Performance was further subdivided into five categories: resuscitation integration, lung ultrasound, transthoracic echo, disease recognition, and treatment. | 2020-08-28 |
| 32850443 | However, for infected or suspected infected cancer patients, their experiences in terms COVID-19 diagnosis, anticancer treatment and prognosis are largely unknown and controversial. […] Here, we summarize the incidence, severe illness rate and mortality according to the published clinical data of COVID-19 in cancer patients and discuss the diagnostic difficulties, anticancer treatment and prognosis of COVID-19-infected cancer patients. | 2020-08-28 |
| 32850461 | Therefore, cancer patients have been greatly affected by this health emergency and, due to their vulnerability to COVID-19, oncologic patient visits have been often delayed or canceled leading to possible under-treatment. | 2020-08-28 |
| 32850499 | The spread of the novel coronavirus (SARS-CoV-2) has triggered a global emergency, that demands urgent solutions for detection and therapy to prevent escalating health, social, and economic impacts. | 2020-08-28 |
| 32850602 | We examine the fundamental concepts including the origin, virology, pathogenesis, clinical manifestations, diagnosis, laboratory, radiology, and histopathologic findings, complications, and treatment. | 2020-08-28 |
| 32850746 | Our deep learning-based model can accurately predict disease severity as well as disease progression in COVID-19 patients using CT imaging, offering promise for guiding clinical treatment. | 2020-08-28 |
| 32850752 | There were no drug treatments or vaccines approved for SARS-CoV-2 at the onset of pandemic, necessitating an urgent need to develop effective therapeutics. […] We conclude with the authors’ perspectives on the future of RNAi therapeutics for combatting SARS-CoV-2. | 2020-08-28 |
| 32850890 | Several broad-spectrum antiviral drugs are being used for treatment; however, there is yet no specific drug or vaccine against the virus. | 2020-08-28 |
| 32850912 | We review the most recent clinical data and current knowledge of secondary bacterial infections and their treatment in SARS-CoV-2 positive patients; case reports from SARS-CoV, MERS-CoV, SARS-CoV2 and the best-studied respiratory virus, influenza, are described. | 2020-08-28 |
| 32850916 | With over 10 million cases and 500 thousand deaths reported worldwide, the need for an effective treatment regimen is evident. […] Historically, convalescent plasma (CP) has been utilized in the treatment of viral respiratory pathogens. […] With increasing mortality around the world from COVID-19 infection, the need for alternative, effective treatment regimens is critical. | 2020-08-28 |
| 32850917 | Demographic, clinical, treatment, and laboratory data were collected and compared. | 2020-08-28 |
| 32850918 | Though extensive research works have been reported in recent days on the development of effective therapeutics against this global health crisis, there is still no approved therapy against SARS-CoV-2. […] In the present study, plant-synthesized secondary metabolites (PSMs) have been prioritized to make a review focusing on the efficacy of plant-originated therapeutics for the treatment of COVID-19. […] The study includes the search of remedies belonging to plant families, susceptible viral candidates, antiviral assays, and the mode of therapeutic action; this attempt resulted in the collection of an enormous number of natural therapeutics that might be suggested for the treatment of COVID-19. | 2020-08-28 |
| 32850921 | The treatment plan was ruxolitinib 20 mg bid for the first 48 h and subsequent two-step de-escalation at 10 mg bid and 5 mg bid for a maximum of 14 days of treatment. […] Already after 48 h of ruxolitinib treatment 16/18 patients showed evident clinical improvement, and after 7 days of treatment 11/18 patients showed fully recovered respiratory function (pO2 > 98% in spontaneous breathing), 4/18 patients had minimal oxygen requirement (2-4 L/m), 1/18 patient showed stable disease, and 2/18 patient showed progressive disease. […] Compliance to ruxolitinib planned treatment was 100% and no serious adverse event was recorded. […] RESPIRE Study (Ruxolitinib for the treatment of acute rESPIratory distREss syndrome, ClinicalTrials.gov Identifier: NCT04361903). | 2020-08-28 |
| 32850922 | Due to the limited evidence available on the dynamics of the virus and effective treatment options available, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has had a huge impact in terms of morbidity and mortality. […] Aims: The purpose of this article is to review the evidence for the multiple treatment options available, to consider the future of this global pandemic, and to identify some potential options that could revolutionize the treatment of COVID-19. […] Method: We thoroughly searched and reviewed various case reports, retrospective analyses, and in vitro studies published in PubMed, EMBASE, and Google Scholar regarding the treatment options used for SARS-CoV, MERS-CoV, and SARS-CoV-2 since its outbreak in an attempt to highlight treatments with the most promising results. | 2020-08-28 |
| 32850924 | Few published studies have evaluated the safety and efficacy of these drugs in the treatment of COVID-19 infection. […] The “Intervention group” received anti-malarial drugs with or without other drugs (Azithromycin) administered as an adjunct to the standard treatment/care. […] The “Control group” received treatment except anti-malarial drugs. […] Conclusions: As very low quality evidence suggests an increased risk of mortality and adverse event with HCQ plus Azithromycin combination (not HCQ alone), caution should be exercised while prescribing this combination for treatment of hospitalized adults with COVID-19 infection. | 2020-08-28 |
| 32850926 | Epidemiological, demographic, laboratory, treatment, and outcome data were recorded, and the risk factors for poor outcome were analyzed. | 2020-08-28 |
| 32850927 | Some authors proposed the discontinuation of ACEIs and ARBs for cardiovascular, kidney, and metabolic diseases, while expert opinions have discouraged that due to limited empirical evidence of their negative effect on COVID-19 outcomes, and that withdrawing treatment may contribute to clinical decompensation in high-risk patients. | 2020-08-28 |
| 32850928 | Temporary intensive care units (ICUs) were therefore set up in isolated hospitals to provide the required standardized care for all severe cases. | 2020-08-28 |
| 32850973 | We propose that a cooperating therapy using inhibitors against multiple targets altogether i.e., ACE2, integrins and sugars could be definitely more effective. | 2020-08-28 |
| 32850977 | Understanding the cellular, and molecular factors involved in immune dysregulation and the high virulence capacity of COVID-19 will help in potential targeted therapy against it. | 2020-08-28 |
| 32850978 | Here we report our perspective on applying GapmeR technology in combination with recombinant angiotensin-converting enzyme 2 (ACE2) in the treatment of COVID-19 patients. | 2020-08-28 |
| 32850989 | Scientific societies expressed their opinion on continuing the therapy with RAS inhibitors in patients with COVID-19 and underlying cardiovascular diseases. | 2020-08-28 |
| 32851093 | Treatment with low molecular weight heparin was not related to odds of death. | 2020-08-28 |
| 32851612 | Timing of surgery for reducible neonatal inguinal hernias had changed in 55% of centers and the management of urgent feeding gastrostomy referrals and of inflammatory bowel disease patients failing with biological therapy varied considerably. | 2020-08-28 |
| 32851912 | Currently, there is no specific treatment to cure COVID-19. […] Theses phytocompounds (alone or in combination) could be developed into effective therapy against COVID-19. | 2020-08-28 |
| 32852212 | In contrast, the impact of heat-treatment (56 °C for 30 min), which has been used for inactivation of SARS-CoV-2 and other viruses, that may be required prior to analytical measurements in low level biosecurity facilities induced marked changes in both lipoprotein and low molecular weight metabolite profiles. | 2020-08-28 |
| 32852238 | This approach was successful in allowing concomitant delivery of intermittent and continuous nebulized therapy without interruptions. | 2020-08-28 |
| 32852291 | The coronavirus disease 2019 (COVID-19) has significantly impacted health care delivery across the United States, including treatment of cancer. […] We aim to describe the determinants of treatment plan changes from the perspective of oncology physicians across the United States during the COVID-19 pandemic. […] Physician demographics, practice characteristics, and cancer treatment decisions were collected. […] Most physicians (N=285; 70.0% of surgeons, 64.4% of medical oncologists, and 73.4% of radiation oncologists) had altered cancer treatment plans. […] Most respondents were concerned about their patients’ COVID-19 exposure risks, but this was the primary driver for treatment alterations only for medical oncologists. […] For surgeons, the primary driver for treatment alterations was conservation of personal protective equipment, institutional mandates, and external society recommendations. […] The COVID-19 pandemic has caused a majority of oncologists to alter their treatment plans, but the primary motivators for changes differed by oncologic specialty. […] This has implications for reinstitution of standard cancer treatment, which may occur at differing time points by treatment modality. | 2020-08-28 |
| 32852316 | Limited availability of alcohol and other substances coupled with decreased accessibility to substance use treatment poses a substantial risk to this population. | 2020-08-28 |
| 32852324 | Six pregnant patients were admitted with severe or critical COVID-19 at Massachusetts General Hospital from April to June 2020 and received inhalational nitric oxide therapy. | 2020-08-28 |
| 32852338 | To compare outcomes in patients hospitalized with coronavirus (COVID-19) receiving famotidine therapy with those not receiving famotidine. | 2020-08-28 |
| 32852396 | The sample consisted of 15 patients aged 12 to 18 years receiving treatment in the Pediatric Hematology and Oncology Unit in Altinbaş University Medical Faculty Bahçelievler Medikalpark Hospital and 33 parents of the same unit patients aged between 6 and 18, and their 35 healthy peers and their parents. | 2020-08-28 |
| 32852513 | To beta test a secure teleophthalmology mobile app at military treatment facilities in Afghanistan. […] This prospective case series included 16 military treatment facilities at diverse roles of care including forward operating bases in Afghanistan and 1 location outside of Afghanistan. […] Mean initial response time, agreement between the teleophthalmology diagnosis and final diagnosis, treatment and management following recommendations outlined in the Joint Trauma System clinical practice guidelines, prevention of the need for aeromedical evacuation, user satisfaction, and security and the Health Insurance Portability and Accountability Act compliance of consult. […] The treatment and management followed recommendations outlined in the Joint Trauma System Clinical Practice Guidelines for Eye Trauma: Initial Care in 28 consults (100%). | 2020-08-28 |
| 32853024 | Viral pneumonias remain global health threats, as exemplified in the SARS-CoV-2 pandemic, requiring novel treatment strategies both early and late in the disease process. […] Mice were challenged with the Sendai paramyxovirus in the presence or absence of Pam2-ODN treatment. […] Enhanced survival of Sendai virus pneumonia with Pam2-ODN treatment was associated with reductions in lung virus burden and with virus inactivation prior to internalization. | 2020-08-28 |
| 32853121 | The most common primary ethical issues were code status (n = 11), obligation to provide nonbeneficial treatment (n = 3), patient autonomy (n = 3), resource allocation (n = 3), and delivery of care wherein the risk to staff might outweigh the potential benefit to the patient (n = 3). […] An additional nine consultations raised concerns about staff safety in the context of likely nonbeneficial treatment as a secondary issue. | 2020-08-28 |
| 32853310 | The objective of this narrative review of the literature is to synthesize in a concrete way the information available on potential drugs for the treatment of patients with COVID-19 and to serve as a support guide for health professionals. […] However, until the results of these trials are available, the best available evidence should be used for the prevention and treatment of COVID-19. | 2020-08-28 |
| 32853370 | From mid-January 2020, Ethiopia started to prepare for the prevention and treatment of COVID-19. […] However, some hospitals have been closed for other healthcare services and have been turned into isolation and treatment centers for COVID-19. | 2020-08-28 |
| 32853434 | Treatment with corticosteroids and/or intravenous immunoglobulins was attempted, resulting in rapid recovery from neurological disturbances in two cases. | 2020-08-28 |
| 32853491 | The importance of understanding the drivers of COVID-19 on community health is amplified by the ability of SARS-CoV-2 to rapidly change genetic structure, our restricted knowledge about the disease, and limited or non-existent vaccines and treatment options. […] An understanding of basic COVID-19 epidemiology is a prerequisite for curtailing transmission, preventing morbidity and mortality, developing efficacious vaccines, implementing effective infection control protocols, and applying treatment algorithms. | 2020-08-28 |
| 32853546 | We also consider existing nucleoside analogs and novel genomic techniques as potential anti-CoV therapeutics that could be used individually or in combination to target the proofreading mechanism. | 2020-08-28 |
| 32853599 | The presence of potent adaptive immunity even in patients who underwent severe pneumonia sustain the rationale for the development of protective therapeutics against SARS-CoV-2. | 2020-08-28 |
| 32853602 | Patients managed in hospital ward without needing intensive care were compared with those who were transferred in intensive care units (ICU). | 2020-08-28 |
| 32853631 | Clinical and laboratory characteristics, management of immunosuppression, treatment for Covid-19, and clinical outcomes (hospitalization, admission to intensive care unit, mechanical ventilation, or death) were recorded. […] Treatment was mainly based on hydroxychloroquine (24.7%), antiviral drugs (7.8%), and tocilizumab (5.3%). […] Proper management of immunosuppression and tailored treatment of this population remain challenging. | 2020-08-28 |
| 32853672 | As no specific pharmacological treatment has been validated for use in coronavirus disease 2019 (COVID-19), we aimed to assess the effectiveness of azithromycin (AZM) in these patients at a referral centre in Iran. | 2020-08-28 |
| 32853673 | Hydroxychloroquine (HCQ) has been largely used and investigated as therapy for COVID-19 across various settings at a total dose usually ranging from 2400 mg to 9600 mg. | 2020-08-28 |
| 32853675 | Moderate-to-severe QTc prolongation during therapy was defined as a QTc interval >470 ms in men or >480 ms in women. […] All patients received therapy with HCQ in combination with azithromycin (AZM), and 95 (90%) also with lopinavir/ritonavir (LPV/r). […] In this closely screened and monitored cohort, no complications derived from QTc prolongation were observed during pharmacological therapy containing HCQ for COVID-19. | 2020-08-28 |
| 32853893 | To review the efficacy and safety of high dose oral corticosteroids in acute relapses treatment compared to intravenous corticosteroids. […] Descriptive review of the utility of high dose oral corticosteroids for MS relapses treatment was performed. […] One hundred and eighty two patients receiving treatment with high dose oral corticosteroids were included. | 2020-08-28 |
| 32853914 | During the study, some workers tried out cognitive behavioral therapy (CBT) for sleep disorders using methods that were available online and easily accessible. | 2020-08-28 |
| 32853978 | In patients admitted to intensive care units, VTE occurred in 24% (95% PI, 5%-66%), PE in 19% (95% PI, 6%-47%), and DVT alone in 7% (95% PI, 0%-69%). | 2020-08-28 |
| 32853989 | Here, we summarise potential beneficial, non-anticoagulant mechanisms underlying treatment of COVID-19 patients with heparin/LMWH, which include: (i) Inhibition of heparanase activity, responsible for endothelial leakage; (ii) Neutralisation of chemokines, and cytokines; (iii) Interference with leukocyte trafficking; (iv) Reducing viral cellular entry, and (v) Neutralisation of extracellular cytotoxic histones. | 2020-08-28 |
| 32854106 | The adaptation to positive airway pressure (PAP) treatment can also be performed mainly using telemedicine procedures. | 2020-08-28 |
| 32854108 | In summary, the mouse-adapted SARS-CoV-2 MA model demonstrates age-related disease pathogenesis and supports the clinical use of pegylated IFN-λ1a as a treatment for human COVID-196. | 2020-08-28 |
| 32854109 | Within the Policlinico, the historic hospital in the center of Milan, many units were rapidly converted into intensive care units or semi-intensive units for adult patients. | 2020-08-28 |
| 32854169 | After undertaking a literature review, we used the RAND/UCLA methodology with a multi-step process to reach consensus about treatment options, onward referral, and imaging. […] The panel undertook a process of ranking and classifying appropriateness of different investigations and treatment options for new onset loss of sense of smell during the COVID-19 pandemic. […] Using a 9-point Likert scale, panellists scored whether a treatment was: Not recommended, optional, or recommended. […] Disagreement meant no recommendation was made regarding one treatment, using Vitamin A drops. […] This study identified the appropriateness of olfactory training, different medical treatment options, referral guidelines and imaging for patients with COVID-19-related loss of sense of smell. | 2020-08-28 |
| 32854262 | Currently, no specific treatment for SARS-CoV-2 infection has been identified; however, certain drugs have shown apparent efficacy in viral inhibition of the disease. | 2020-08-29 |
| 32854391 | The outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has ignited an unprecedented effort from the scientific community in the development of new vaccines on different platforms due to the absence of a broad and effective treatment for COVID-19 or prevention strategy for SARS-CoV-2 dissemination. | 2020-08-29 |
| 32854480 | The patient with generalized dystonia was managed with medication adjustment as he chose to defer battery replacement. | 2020-08-29 |
| 32854513 | This was observed particularly in critically ill patients with high D-dimer levels who required no anticoagulant medication. | 2020-08-29 |
| 32854562 | In this article, we share a service evaluation and experiences dealing with the crisis through using a virtual office approach with video conferencing to manage emergency consultations, treatment reviews, new patient and multidisciplinary clinics in a hospital orthodontic unit. | 2020-08-29 |
| 32854573 | This study highlights that large scale prospective and randomized studies should be conducted in order to investigate the role of TKIs in the treatment of COVID-19. | 2020-08-29 |
| 32854761 | A traditional Chinese medicine rehabilitation (TCMR) program consisting of acupressure therapy and Liu Zi Jue Qigong can be used as a complementary therapy for COVID-19. […] A total of 128 patients with COVID-19 aged from 20 to 80 years will be recruited and assigned randomly into a guideline therapy group and a guideline therapy plus TCMR group at a 1:1 ratio. […] Patients in both groups will receive guideline therapy. […] The patients in the intervention group will perform acupressure therapy and Liu Zi Jue Qigong exercises in addition to conventional treatments twice a day and will be persistent from admission to discharge. […] The assessments of the clinical scales will be performed at three points (before treatment, the 7th day during hospitalization, and the discharge day). […] This trial will provide high-quality evidence of the value of TCMR, which consists of acupressure therapy and Liu Zi Jue Qigong exercises, for treating patients with severe COVID-19. | 2020-08-29 |
| 32854774 | Therefore, treatment with immunomodulating agents should be initiated as soon as hyperinflammation is established. […] Irrespective of this, patient’s serum interleukin 6 and aminotransferases remained elevated even after a month from treatment. […] Current and future research should also investigate the impact of experimental therapies on lung tissue healing and regeneration, as well as long-term treatment toxicities. | 2020-08-29 |
| 32854812 | Demographic characteristics, clinical data, laboratory findings, imaging and echocardiographic findings, treatment and outcomes were collected. | 2020-08-29 |
| 32854921 | In addition, the ultrasound score correlated positively with supplemental oxygen therapy (r=0.45, p=0.041) and negatively with minimal oxygen saturation at ambient air (r=-0.652, p<0.01). | 2020-08-29 |
| 32854983 | Engaging patients with stimulant use disorder in regular treatment has become even more difficult during this pandemic, which has resulted in many cuts to addiction treatment programs. […] The most effective treatment options for stimulant use disorder are psychosocial interventions, which rely heavily on in-person interactions, posing an added challenge during physical distancing. […] In particular, contingency management (CM) is a behavioral therapy that utilizes tangible reinforcements to incentivize targeted behavior changes, and is an effective treatment intervention used for stimulant use disorder. […] This paper highlights the treatment challenges for individuals with stimulant use disorder and the importance of adapting CM programs during COVID-19. | 2020-08-29 |
| 32854985 | MSCs are being studied as a therapy option for many inflammatory and immune disorders and are approved to treat acute graft-versus-host disease (GvHD). | 2020-08-29 |
| 32854988 | These patients are frequently admitted to our Intensive Care Units in relation to acute respiratory distress syndrome. […] The lack of a treatment based on scientific evidence has led to the use of different management guidelines, in many cases with rapid changes in the applied protocols. […] Recent reviews in reputed journals have underscored the lack of proven therapies and the need for clinical trials to establish clear and objective treatment guidelines. […] The present study provides an update on the currently applied treatment, and intends to offer help in relation to daily care, without seeking to replace the protocols adopted in each individual center. | 2020-08-29 |
| 32855085 | This situation would affect the diagnosis and treatment of patients with STEMI. […] COVID-19 pandemic dramatically reduced the number of STEMI patients attending hospital and delay the time to treatment and consequently, a higher in-hospital mortality. | 2020-08-29 |
| 32855187 | In this clinical case series, we report our experience to date with neurologic complications of extracorporeal membrane oxygenation therapy for COVID-19 Acute Respiratory Distress Syndrome. […] We have found an unexpectedly increased rate of complications as demonstrated by neuroimaging compared with meta-analysis data in extracorporeal membrane oxygenation therapy for all Acute Respiratory Distress Syndrome etiologies over the past few decades and compared with the most recent baseline data describing the incidence of neurologic complication in all patients with COVID-19. […] Continued analysis of extracorporeal membrane oxygenation therapy in this disease paradigm is warranted. | 2020-08-29 |
| 32855306 | To construct the underlying models, we employed 10-year net CRC survival for England 2008-2017, 2WW pathway CRC case and referral volumes and per-day-delay HRs generated from observational studies of diagnosis-to-treatment interval. […] Delays in the pathway to CRC diagnosis and treatment have potential to cause significant mortality and loss of life years. | 2020-08-29 |
| 32855385 | We performed a parallel assigned controlled, non-randomized, phase 1 clinical trial to evaluate the safety of human umbilical cord-derived mesenchymal stem cells (UC-MSCs) infusions in the treatment of patients with moderate and severe COVID-19 pulmonary disease. […] The treatment group received three cycles of intravenous infusion of UC-MSCs (3 × 107 cells per infusion) on days 0, 3, and 6. […] Both groups received standard COVID-treatment regimens. […] Mechanical ventilation was required in one patient in the treatment group compared with four in the control group. […] Phase 2/3 randomized, controlled, double-blinded trials with long-term follow-up are needed to evaluate the therapeutic use of UC-MSCs to reduce deaths and improve long-term treatment outcomes in patients with serious COVID-19. | 2020-08-29 |
| 32855401 | The human monoclonal antibodies described here represent a promising basis for the design of efficient combined post-exposure therapy for SARS-CoV-2 infection. | 2020-08-29 |
| 32855413 | They are strong drug candidates for the treatment of human coronavirus infections because they have already been successful in animals. […] The work here lays the framework for their use in human trials for the treatment of COVID-19. | 2020-08-29 |
| 32855629 | Corticosteroid treatment and more serious disease were also risk factors for viral clearance and patients’discharge. | 2020-08-29 |
| 32855710 | Linear regression was used to analyze the relationship between the serum CRP, SAA levels and treatment days in recovered patients. […] Linear regression analysis revealed that CRP and SAA levels were negatively correlated with treatment days in recovered patients (r=-0.761, -0.795, respectively). | 2020-08-29 |
| 32855764 | Therefore, this review is aimed at discussing natural compounds with both antioxidant and antiviral activities, specifically against coronavirus infection, in an attempt to contribute to global researches for discovering effective therapeutic agents in the treatment of coronavirus infection and its severe clinical complications. | 2020-08-29 |
| 32855778 | The co-prescription of psychotropics with COVID-19 medication is not uncommon. […] Medical databases, including Google Scholar, PubMed, Web of Science, and Scopus were searched to identify studies in English with keywords related to psychiatric disorders, medications used in the treatment of psychiatric disorders and COVID-19 medications. […] There is a great potential for DDIs between psychiatric and COVID-19 medications ranging from interactions that are not clinically apparent (minor) to those that produce life-threatening adverse drug reactions, or loss of treatment efficacy. […] However, psychiatric medication can be safely used in combination with COVID-19 pharmacotherapy with either a wise selection of medication with the least possibility of interaction or careful patient monitoring and management. | 2020-08-29 |
| 32855779 | However, the treatment will take more time for them in comparison with the general population. | 2020-08-29 |
| 32855780 | Our study focuses on the voice of our patients, on clues to adapt treatment, and on the impact of the pandemic on the therapeutic alliance. […] Fifteen addicted patients (11 under treatment and 4 in recovery) were interviewed by 4 interviewers according to the COREQ (consolidated criteria for reporting qualitative research). […] The use of psychoactive substances differed between the patients in treatment with those who are in stable recovery. […] Those still in treatment were fighting against the temptation to start using again; they felt emotionally isolated and sometimes patronized by health care workers. […] Remembering this common expression, “we are all in this together”, shared decision making could very well be used to shape effective and receptive treatment interventions during the different challenges faced at different stages of the COVID-19 epidemic. | 2020-08-29 |
| 32855781 | Awareness of the current outbreak of Coronavirus Disease - 2019 (COVID-19) affecting the nervous system and identifying its possible ways to enter the Central Nervous System (CNS) are critical for the prevention and treatment of the disease. | 2020-08-29 |
| 32855814 | Lockdowns, travel restrictions, quarantines, social distancing, and other strict public health measures are playing their part in delaying the spread of infection, but a safe and potent vaccine, effective therapeutics, point-of-care diagnostics, and other health products are desperately needed because it may not be practically possible for governments to extend these measures for an indefinite period of time. […] On March 23, Costa Rica submitted a proposal to the Director-General of the World Health Organization for the creation of a global pooling mechanism in order to facilitate access to and use of intellectual property, trade-secret know-how, regulatory data, cell lines, product blueprints, and other proprietary data for technologies that are useful for the detection, prevention, control, and treatment of the COVID-19 pandemic. | 2020-08-29 |
| 32855992 | GCSF is currently investigated as additional therapy in ARDS, but this case report emphasizes that risks and benefits must be carefully assessed. | 2020-08-29 |
| 32856024 | To provide guidance to palliative care teams naive to the palliative care demand associated with a surge of coronavirus cases, we document our protocol to best optimize palliative care resources. […] Measurements: A retrospective chart review was performed to analyze the effect of palliative care consultation on completion of goals-of-care conversations and the life-sustaining treatment (LST) document, an advance directive form specific to the Veterans Affairs hospital system between March 29, 2020 and May 1, 2020. […] Conclusions: We found that standardizing palliative care consultation on all COVID-19 positive ICU admissions subjectively alleviated the burden on ICU providers and staff in the midst of a crisis, resulted in increased documentation of patient goals-of-care preferences/LSTs, facilitated clinical updates to family members, and better distributed clinical burden among palliative team members. | 2020-08-29 |
| 32856034 | Many patients received investigational medications for treatment of COVID-19, including 48 patients on remdesivir and 4,232 on hydroxychloroquine. […] These data can inform strategies to prioritize prevention and treatment for this disease. | 2020-08-29 |
| 32856063 | We retrospectively evaluated 5 adult patients infected with SARS-CoV-2 who were admitted to our thoracic surgery unit between 29 January 2020 and 4 March 2020 for surgical treatment of a primary lung cancer. […] Additional strategies are needed to reduce the risk of morbidity and mortality from SARS-CoV-2 infection during treatment for lung cancer. | 2020-08-29 |
| 32856202 | This manuscript aims to present a treatment algorithm we applied to manage COVID-19 patients admitted to our hospital. | 2020-08-29 |
| 32856214 | The screening tool met a number of essential criteria: (1) simple and easy to use, (2) included the most common signs and symptoms as knowledge of COVID-19 infection changed, (3) was congruent with the overall screening procedures of the medical center, (4) included questions about risk factors for and environmental exposures related to COVID-19, and (5) assessed patient’s current cancer history and treatment status. […] Oncology clinicians can modify this tool to triage patients as well as to screen patients in a variety of outpatient settings (e.g., chemotherapy infusion units, radiation therapy departments). | 2020-08-29 |
| 32856282 | Darunavir is an anti-HIV protease inhibitor repurposed for SARS-CoV-2 treatment. | 2020-08-29 |
| 32856333 | Patients were also evaluated at the beginning of treatment (T0). […] Lockdown interfered with treatment outcomes: the descending trend of ED-specific psychopathology was interrupted during the epidemic in BN patients. | 2020-08-29 |
| 32856339 | Evidence suggests that vitamin D supplementation could potentially be effective either in treatment or prevention of coronavirus disease 2019 (Covid-19). | 2020-08-29 |
| 32856728 | Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection has rapidly spread throughout the world since December 2019 to become a global public health emergency for the elevated deaths and hospitalizations in Intensive Care Units. | 2020-08-29 |
| 32856955 | Inflammatory Bowel Disease (IBD) patients frequently require immunosuppressive therapy and are known to be at risk of opportunistic infections. | 2020-08-29 |
| 32857014 | Artificial intelligence and high-performance computing have accelerated research into understanding the virus and developing targeted therapeutics to treat infection and prevent transmission. | 2020-08-29 |
| 32857226 | Considering the research team’s experience in using nano-clays as high-affinity material for cancer metastasis, melanoma treatment, and bone regeneration, we propose to use these nano-clays for the prevention/treatment of COVID-19. | 2020-08-29 |
| 32857301 | The role of the antiviral therapy in treatment of COVID-19 is still a matter to be investigated. […] The patients received the national treatment protocol containing hydroxychloroquine (400 mg BD in first day and then 200 mg BD) plus atazanavir/ritonavir (300/100 mg daily) for 7 days. | 2020-08-29 |
| 32857620 | We assessed azithromycin’s effect on the aforementioned genes and their associated pathways to evaluate its potential use as a possible treatment. | 2020-08-29 |
| 32857671 | The current vaccine and treatment development strategies ought to consider such systems medicine perspectives rather than a narrower focus on the lung infection only. […] We suggest the blockage of IL-6 signaling and its downstream mediators such as Janus kinases (JAKs), and signal transducer and activators of transcription (STATs) offer potential hope for the treatment of severe cases of COVID-19. | 2020-08-29 |
| 32857679 | Currently multiple drugs and their combinations are being tried for the treatment of the COVID-19 disease, but none approved. […] In absence of definitive and approved treatment, it is imperative that prevention of COVID-19 infection is of utmost importance. | 2020-08-29 |
| 32857693 | When it became clear that the virus mainly attacks the lungs by causing parenchymal changes in the form of multifocal pneumonia of different levels of severity, imaging became paramount in the assessment of disease severity, progression, and even response to treatment. | 2020-08-29 |
| 32857811 | Having poor knowledge and attitude of the disease among health care providers could bring in impeded effect in the supportive treatment and, it increases the spread of the pandemic. | 2020-08-29 |
| 32857836 | This report summarizes issues that render a COVID-19 model daunting to establish (SARS-CoV-2’s potential to cause severe/fatal illness, its high transmissibility, and lack of a “rescue treatment” to prevent progression from mild/moderate to severe clinical illness) and it proffers prudent strategies for stepwise model development, challenge virus selection, guidelines for manufacturing challenge doses, and ways to contain SARS-CoV-2 and prevent transmission to household/community contacts. | 2020-08-29 |
| 32857838 | Treatment completion and screening for drug resistance decreased continuously in 2020. | 2020-08-29 |
| 32857878 | We review strengths and weaknesses of these studies, and we also discuss the hypothetical benefit and anticipated challenges of fibrinolytic therapy in COVID-19. | 2020-08-29 |
| 32857990 | We suggest benefit predominantly resulted from early triggers to review/enhance anticoagulation management, without exposing lower-risk patients to potential risks of full anticoagulation therapy. | 2020-08-29 |
| 32858232 | In this regard, the chemokine receptor-ligand nexus has been reported as potentially important in severe COVID-19 disease pathogenesis and its treatment. […] Applying that knowledge, together with newly discovered potential host genomic factors associated with COVID-19, may lead to a more comprehensive understanding of the pathogenesis and treatment outcomes in COVID-19 patients. | 2020-08-29 |
| 32858315 | Herein, we present the first case of SARS-CoV-2 infection with manic-like symptoms and describe the diagnosis, clinical course, and treatment of the case, focusing on the identifications of SARS-CoV-2 in the specimen of cerebrospinal fluid (CSF). […] The patient received Olanzapine for treatment and his mood problems concurrently improved as indicated by scores of Young Manic Rating Scale (YMRS). | 2020-08-29 |
| 32858368 | During epidemic outbreaks, epilepsy course can be modified by different physical and psychological stressors and, most importantly, by irregular therapy intake. […] As demonstrated in other infective outbreaks, good antiepileptic drug (AED) supplying, precise information, and reassurance are the most important factors in chronic conditions to minimize psychological and physical stress, and to avoid unplanned treatment interruptions. | 2020-08-29 |
| 32858474 | Pillars for good glycemic control are good life style modification with proper medication under medical guidance. | 2020-08-29 |
| 32858476 | Overall, 89.47% participants experienced disruption in therapy. | 2020-08-29 |
| 32858533 | This case highlights the need for clinicians to have elevated vigilance with regard to screening and treatment for venous thromboembolism in high-risk patients, such as spinal cord injury with a concurrent diagnosis of coronavirus virus disease 2019. | 2020-08-29 |
| 32858551 | Lung ultrasound (LUS) is widely used in intensive care units because it provides timely information noninvasively. | 2020-08-29 |
| 32858566 | We investigated the potential hepatotoxicity of lopinavir/ritonavir recently used in the treatment of Severe Acute Respiratory Syndrome Coronavirus. | 2020-08-29 |
| 32858623 | Treatment of COVID-19, especially the use of antivirals, must be closely monitored. | 2020-08-29 |
| 32858940 | The severe form of the disease is often associated with acute respiratory distress syndrome (ARDS), and most critically ill patients require mechanical ventilation and support in intensive care units. […] To date, no specific antiviral therapy is available for patients with SARS-CoV-2 infection. | 2020-08-30 |
| 32859016 | Methods: Cancer patients on active treatment and healthcare workers were enrolled. […] Results: The study included 164 cancer patients on active intravenous treatment and 107 healthcare workers at the cancer center. | 2020-08-30 |
| 32859332 | COVID-19 pandemic had resulted in a massive increase in the number of patients admitted to intensive care units (ICUs). […] Clinical dieticians estimated energy targets for acute and post-acute phases at patient’s admission and suggested adaptations of nutrition therapy. […] At the end of the current pandemic wave, a 13-item questionnaire was emailed to the ICU medical team to obtain their opinion on the suggested nutritional therapy. […] The protocol was followed by 92% of MDs, and almost all participants (95%) were convinced that adaptations of nutritional therapy had beneficial effects on patients’ outcomes. […] Nutritional therapy in critically ill COVID-19 patients is a challenge and the implementation of this specific pandemic simplified nutritional protocol was assessed as useful by a great majority of physicians. […] Pragmatic and simplified protocols are useful for ensuring the quality of nutritional therapy and could be used in future studies to assess its actual impact on the clinical outcomes of COVID-19 patients. | 2020-08-30 |
| 32859393 | The aims were to examine whether exposure to COVID-19 predicts elevated levels of anxiety and post-traumatic stress symptoms and whether pre-pandemic maltreatment experiences exacerbate this impact on mental health in adolescents. […] The largest variance in PTSS and anxiety problems was explained by ACEs, with more pre-pandemic maltreatment experiences predicting more PTSS (effect size beta = 0.16∼0.27), and more anxiety (effect size beta = 0.32∼0.47). […] After pre-pandemic maltreatment experiences the impact of exposure to COVID-19 on mental health may be stronger. | 2020-08-30 |
| 32859394 | Child maltreatment has generally been viewed as a highly individualistic problem by focusing on stressors and parenting behaviors that impact individual families. | 2020-08-30 |
| 32859406 | In anticipation of the unfortunate reality of community spread and high disease burden, the Anesthesia and Obstetrics and Gynecology departments at NewYork-Presbyterian / Columbia University Irving Medical Center, an academic hospital system in Manhattan, created an Obstetric Intensive Care Unit on Labor and Delivery to defray volume from the hospital’s preexisting intensive care units. | 2020-08-30 |
| 32859477 | Hydroxychloroquine (HCQ) was proposed as potential treatment for COVID-19. […] We set-up a multicenter Italian collaboration to investigate the relationship between HCQ therapy and COVID-19 in-hospital mortality. […] We used multivariable Cox proportional-hazards regression models with inverse probability for treatment weighting by propensity scores, with the addition of subgroup analyses. | 2020-08-30 |
| 32859666 | The PrAISED process evaluation will enable us to understand how distancing and isolation affected participants, their activity and exercise routines and whether the therapy programme could be continued with remote support. | 2020-08-30 |
| 32859812 | Towards this end, the Indian Society of Neuro-Oncology (ISNO) constituted an online expert panel with adequate representation from all major treatment modalities (neuro-surgery, radiation oncology, and pediatric/medical oncology) to formulate a “COVID-19 context” position statement to guide the care of neuro-oncology patients during the ongoing crisis. […] The ISNO position statement suggests graded prioritization (based on clinical presentation, type of tumor, expected prognosis, and relevance of immediate therapy) for efficient utilization of resources and provides a framework through a set of general considerations, treatment modality-based considerations, and disease-specific considerations for the guidance of healthcare professionals involved in the delivery of care and services to patients with CNS tumors. | 2020-08-30 |
| 32859814 | We observed a significant increase in problems faced due to this pandemic, specifically, the inability to access health care, and difficulty procuring medication. | 2020-08-30 |
| 32859864 | Further studies are desired to unravel the varied neurological manifestations, treatment, outcome and long-term sequel in COVID-19 patients. | 2020-08-30 |
| 32859963 | In all, 120 (43%) NICUs reported reductions in therapy services, lactation medicine, and/or social work support. | 2020-08-30 |
| 32860038 | Risch, review the literature he presented and demonstrate why it is not of sufficient quality to support scale up of HCQ+AZ, and then discuss the literature that has been generated since his publication, which also does not support use of this therapy. […] Unfortunately, the current scientific evidence does not support HCQ+AZ as an effective treatment for COVID-19, if it ever did; and even suggests many risks. […] Continuing to push the view that it is an essential treatment in the face of this evidence is irresponsible and harmful to the many people already suffering from infection. | 2020-08-30 |
| 32860101 | The severity of the symptoms was mild-moderate in the majority with a predominance of febrile syndrome, with mild radiological involvement and in some cases with mild respiratory distress that required oxygen therapy. | 2020-08-30 |
| 32860209 | Literature on the impact of GCs therapy on HPA axis and on the consequences of coadministration of GCs and other drugs in SARS-CoV-2 patients has been reviewed. […] GC treatment can cause symptoms of hypercortisolism, especially in patients with individual hypersensibility, or hypoadrenalism after drug withdrawal, due to hypothalamic-pituitary-adrenal (HPA) axis suppression, with consequences in terms of increased morbidity and mortality risk. […] Physicians involved in the management of patients affected by COVID-19 should be aware of the need of an appropriate GC dose tapering, and of potential interaction of GCs with antiviral therapy and drugs used to treat associated co-morbidities. | 2020-08-30 |
| 32860226 | Our aim was to examine whether COVID-19 had an impact on access to PD medication by region and income. […] This study was conducted as part of a survey sent to members of the Movement Disorders Society focusing on access to PD medication globally. […] Of 346 responses, 157 (45.4%) agreed that COVID-19 had affected access to PD medication, while 189 (54.6%) disagreed. […] 22.8% of high-income and 88.9% of low-income countries’ respondents agreed that access to PD medication was affected by COVID-19. 59% of all ‘yes’ respondents reported increased disability of patients as an impact. […] Access to PD medication is likely to have been affected by COVID-19 and result in deterioration of patients’ symptomatic control. | 2020-08-30 |
| 32860280 | The identification of factors that are associated with the enhanced prevalence of COVID-19 facilitates early diagnosis, and adequate and prompt treatment. | 2020-08-30 |
| 32860297 | We read with interest the letter by Maccio et al., which postulates a role for defibrotide (DF) in the treatment of coagulation disorders observed in COVID-19 [1]. […] DF has indeed been shown to improve overall survival in patients with severe VOD/SOS [2] and may be beneficial in the treatment of COVID-19, but not exclusively because of the observed similarities to VOD/SOS. | 2020-08-30 |
| 32860325 | In our study, non ICU-subjects with deep vein thrombosis (DVT) more frequently required oxygen supplementation (100.0 % vs 83.7 %) and high flow nasal oxygen therapy or non-invasive ventilation (NIV) (60.0% vs 8.1%) compared to those who had no DVT (2). | 2020-08-30 |
| 32860358 | In response to the global outbreak caused by SARS-CoV-2, this article aims to propose the development of nanosystems for the delivery of hydroxychloroquine in the respiratory system to the treatment of COVID-19. […] Nanosystems for the delivery of drugs in the respiratory system may be a viable alternative for the administration of hydroxychloroquine, which may enhance the therapeutic effect of the drug with a consequent decrease in its toxicity, providing greater safety for implementation in the clinic in the treatment of COVID-19. | 2020-08-30 |
| 32860394 | Radionuclide therapy has had an increasing role in clinical practice. […] COVID-19 is another risk that must be considered in treatment planning. […] The most common radionuclide therapies involve patients with differentiated thyroid cancer (DTC) who need radioiodine therapy (RAI), patients with neuroendocrine tumours (NETs) who need peptide receptor radionuclide therapy (PRRT), patients with hepatocellular carcinoma (HCC) who need therapy with radiolabelled microspheres, and patients with prostate cancer and bone metastasis who need radionuclide palliative therapy. […] Treatment decisions for thyroid cancer and NETs are challenging in this environment. […] Any decision to postpone therapy must be carefully considered, balancing risks and benefits. […] A risk of worsened prognosis due to delayed or suboptimal cancer treatment must be weighed against the risk of severe COVID-19 illness. | 2020-08-30 |
| 32860431 | Treatment algorithms have been attempted as parallel to the increasing experience with Covid-19. […] However, the other factors those enhance the use of Anakinra in the situation of viremia also could be sorted as no response to full dose antivirals, antiviral side effects or no success to antiviral treatment. | 2020-08-30 |
| 32860432 | The primary outcome was de-escalation in oxygen therapy. […] One-to-two propensity matching identified 20 versus 40 patients in the TCB and no-TCB treatment arms. […] Early treatment with TCB in patients admitted for COVID-19 led to an improvement in their oxygen status during hospitalization. | 2020-08-30 |
| 32860474 | In the United Hospital of Ancona, a specialist outpatient clinic dealing with diagnosis and treatment of immunomediated skin diseases has been operating since 1985, and 291 patients with hidradenitis suppurativa (HS) are currently being treated. […] Since the end of February 2020, when the SARS-CoV-2 pandemic had already spread in most of Italy, a task force comprised of seven specialists has been set up with the aim of addressing problems relating to the specific risk for this class of patients in relation to SARS-CoV-2 infection and immunosuppressive ongoing therapy. […] The main goal was to evaluate the risk/benefit in modulating treatment taking into consideration patients’ risk of exposure to SARS-CoV-2 virus. | 2020-08-30 |
| 32860573 | The natural history of the disease seems to be a rapid self-limited conjunctivitis that improves without treatment and does not affect visual acuity nor associate short-term complications. | 2020-08-30 |
| 32860649 | Epidemiological, demographic, clinical, laboratorial, management, treatment, and outcome data were also collected and analyzed. […] The current treatment is mainly antibiotics, antiviral, and traditional Chinese medicine, while a couple of patients has used methylprednisolone. […] Only 1 patient out of both groups got even worse despite this active treatment. | 2020-08-30 |
| 32860672 | Therefore, early coagulation tests followed by dynamic monitoring is useful for recognizing coagulation disorders accompanied by COVID-19 and guiding timely therapy to improve prognosis. | 2020-08-30 |
| 32860682 | The mortality rate was reduced by the use of antifungal therapy (Mortality: 38·5% in patients receiving therapy versus 90% in patients not receiving therapy (P: 0.008). […] The survival benefit observed in patients receiving antifungal therapy implies that the proposed diagnostic and defining criteria are appropriate. | 2020-08-30 |
| 32860880 | With stewardship interventions, the duration of antibiotic therapy and length of stay of hospitalized patients can be reduced significantly. | 2020-08-30 |
| 32860964 | Treatment was mainly with tocilizumab, an intermediate-high dose of corticosteroids (IHDC), a pulse dose of corticosteroids (PDC), combination therapy, or no treatment. […] Propensity scores were used as confounders, matching variables and for the inverse probability of treatment weights (IPTWs). […] In all, 88, 117, 78 and 151 patients treated with tocilizumab, IHDC, PDC, and combination therapy, respectively, were compared with 344 untreated patients. […] The IPTW-based hazard ratios (odds ratio for combination therapy) for the primary endpoint were 0.32 (95%CI 0.22-0.47; p < 0.001) for tocilizumab, 0.82 (0.71-1.30; p 0.82) for IHDC, 0.61 (0.43-0.86; p 0.006) for PDC, and 1.17 (0.86-1.58; p 0.30) for combination therapy. | 2020-08-30 |
| 32861124 | The aim of this study was to assess the efficacy and feasibility of virtual follow-up in patients who have undergone intratympanic steroid injection for treatment of tinnitus during COVID-19 pandemic. | 2020-08-30 |
| 32861152 | EEG recordings in such patients can identify pathological patterns that will benefit from treatment with anti-seizure medications. | 2020-08-30 |
| 32861187 | An extensive sampling campaign, including nine municipal wastewater treatment plants, has been conducted in different cities of the Federal State of North Rhine-Westphalia (Germany) on the same day in April 2020, close to the first peak of the corona crisis. | 2020-08-30 |
| 32861268 | Metformin is the most commonly prescribed first-line medication for T2D, but its impact on the outcomes of individuals with COVID-19 and T2D remains to be clarified. […] Our findings provide clinical evidence in support of continuing metformin treatment in individuals with COVID-19 and pre-existing T2D, but acidosis and kidney function should be carefully monitored in individuals with severe COVID-19. | 2020-08-31 |
| 32861275 | In this prospective observational study done at two UK intensive care units, we recruited patients with ARDS due to COVID-19. | 2020-08-31 |
| 32861692 | However, the unique aspects of COVID-19 confound both the diagnosis and treatment of PE, and therefore require modification of established algorithms. | 2020-08-31 |
| 32861702 | To determine the outcomes of oral cavity squamous cell cancer (OSCC) patients treated with non-surgical approach i.e. definitive intensity-modulated radiation therapy (IMRT). | 2020-08-31 |
| 32861823 | Demographic characteristics and epidemiological data, medical history, laboratory tests, cardiology evaluations, treatment, and clinical outcomes were analyzed. […] Anti-inflammatory treatment (immunoglobulin and/or corticosteroids) was prescribed in 24 patients. […] Education and alerts are required for clinical teams to establish an early diagnosis and prompt treatment. | 2020-08-31 |
| 32861850 | SARS-CoV-2 (COVID-19) patients with associated thromboembolic events have demonstrated poor outcomes despite the use of anticoagulation therapy and surgical intervention. […] Initial treatment with systemic thrombolysis, which restored patency of the aortoiliac occlusion, was followed by open thrombectomies of the infrainguinal occlusions. | 2020-08-31 |
| 32861865 | Patients with arterial thromboembolic complications and SARS-CoV-2 positive when compared with SARS-CoV-2 negative or admitted for unrelated reasons were younger (64 vs 70 years; P = .027), had a significantly higher body mass index (32.6 vs 25.5; P = .012), a higher d-dimer at the time of imaging (17.3 vs 1.8; P = .038), a higher average in hospital d-dimer (8.5 vs 2.0; P = .038), a greater distribution of patients with clot in the aortoiliac location (5 vs 1; P = .040), less prior use of any antiplatelet medication (21.4% vs 62.5%; P = .035), and a higher mortality rate (40.0% vs 8.0%; P = .041). […] Treatment of arterial thromboembolic disease in COVID-19 positive patients included open thromboembolectomy in six patients (40%), anticoagulation alone in four (26.7%), and five (33.3%) did not require or their overall illness severity precluded additional treatment. | 2020-08-31 |
| 32861887 | Herein, we reported a successful critical case of COVID-19 and shared our experience of treatment, which would do a favor for other COVID-19 patients. . […] And then we found that it was complicated with acute cor pulmonale(ACP) by ultrasound examination, dobutamine and diuretic were used for the treatment of ACP caused by ARDS successfully, and the P/F ratio went up to about 250mmHg. […] Seven days later after admission, the endotracheal intubation was successfully removed, after extubation, High-Flow nasal cannula(HFNC) oxygen therapy was used as a sequential strategy to prevent reintubation. […] Our case presented the treatment process of a critical COVID-19. […] Effective therapy was crucial to heal COVID-19, and organ function support therapy, especially the cardiorespiratory function support therapy, was the core of treatment. | 2020-08-31 |
| 32861965 | There is currently no licensed antiviral treatment available to prevent human CoV infection. […] The widespread clinical use and existing knowledge on antiviral mechanisms of remdesivir, lopinavir/ritonavir and chloroquine/hydroxychloroquine in the treatment of previous epidemic diseases, namely, severe acute respiratory syndrome (SARS) and Middle East respiratory syndrome (MERS), may be helpful in the combat with novel SARS-CoV-2 infection. […] We provide an overview of the current evidence into the mechanisms of action of these available drugs which are repurposed for treatment of the new virus. […] Numerous studies demonstrated the ability of remdesivir to inhibit SARS-CoV-2 replication but future research would be needed to understand the exact mode of action of lopinavir/ritonavir and chloroquine/hydroxychloroquine in SARS-CoV-2 infected cells and to use this knowledge in the treatment of the current COVID-19. | 2020-08-31 |
| 32862066 | Strategies for rapid deployment of group-based services, including action steps transitioning to telehealth, clinical protocols, and remote workforce training, early observations and challenges to implementation are described as helpful tools for clinical settings with similar needs to prevent infectious spread while addressing the mental health needs of patients. | 2020-08-31 |
| 32862101 | The potential of this class of compounds may offer an alternative therapeutic agent for ALS treatment. | 2020-08-31 |
| 32862111 | In this study, efficacy and safety of interferon (IFN) β-1b in the treatment of patients with severe COVID-19 were evaluated. | 2020-08-31 |
| 32862265 | Non-operative treatment is not appropriate due to significantly higher mortality, and therefore, these patients are often exposed to COVID-19 in the peri-operative period. | 2020-08-31 |
| 32862396 | This condition is due to the establishment of an “Internet +” diagnosis and treatment model based on online medical application (APP), telemedicine, WeChat service, and consultation hotline in Taizhou. […] Taizhou led in opening the “COVID-19 Prevention and Treatment Special Line” in China, which is conducive to pre-hospital screening, suppressing social panic, and clinical support. | 2020-08-31 |
| 32862472 | However, this therapy has been scarcely studied in kidney transplant (KT) recipients. […] Initial treatment included hydroxychloroquine, antibiotics, and prophylactic anticoagulation. […] Before treatment with TCZ, 3 patients were receiving high-flow oxygen, 4 patients low-flow oxygen and 1 case non-invasive ventilation. […] In conclusion, although treatment with TCZ could be associated with improved clinical outcomes in a subset of KT recipients with COVID-19, further studies are warranted before drawing firm conclusions. | 2020-08-31 |
| 32862474 | Critical care ultrasonography is vital because it provides real time information for diagnosis and treatment. | 2020-08-31 |
| 32862566 | Nonetheless, the risk of infection may not always outweigh oncology treatment benefit. | 2020-08-31 |
| 32862840 | Hydroxychloroquine (CLQ-OH)/azithromycin (ATM) combination therapy is currently being tested for the treatment of COVID-19, with promising results. […] This molecular mechanism may explain the beneficial effects of CLQ-OH/ATM combination therapy in patients with COVID-19. | 2020-09-01 |
| 32863084 | Despite several medical treatment protocols having been established, a comprehensive rehabilitation program that can promote functional recovery is still frequently ignored. […] Apart from medications and life support care, a proper rehabilitation protocol that facilitates recovery from COVID-19 needs to be established and emphasized in clinical practice. | 2020-09-01 |
| 32863086 | The level of impact on the mental health of orthodontic patients in treatment is unknown. […] The type of orthodontic appliance was associated with the anxiety of prolonged treatment duration. […] The manner of communication with patients regarding the postponement of appointments was associated with patients’ concerns of prolonged treatment duration. | 2020-09-01 |
| 32863098 | The message from a physician-which conveyed the crisis of overwhelmed hospitals and consequent risk of people being unable to receive treatment-increased the intent to stay at home the most. | 2020-09-01 |
| 32863137 | Electroconvulsive therapy (ECT), which involves an aerosol-generating procedure from manual ventilation with a bag mask valve while under anesthesia, has undergone drastic practice changes in order to minimize disruption of treatment in the midst of COVID-19. […] There is a universal consensus that ECT is an essential treatment of severe mental illness. | 2020-09-01 |
| 32863144 | These two groups were compared in terms of demographic and clinical characteristics, prevalence of complicated appendicitis, and treatment intention. […] In addition, the epidemic group had a lower score of patient’s intention to seek treatment than the pre-epidemic group (9.5 ± 2.7 vs. […] Based on the multivariate analysis, the risk factors for complicated appendicitis included the time from symptoms onset to admission (OR = 1.075) and the patients’ intention to receive treatment (OR = 0.541). | 2020-09-01 |
| 32863274 | Here, we advocate a highly favourable opportunity for the treatment of COVID-19 disease by repurposing a long-serving medical agent with an excellent history of clinical use, namely heparin. | 2020-09-01 |
| 32863290 | Among these, 991 (63%) clinicians were involved directly in frontline treatment. | 2020-09-01 |
| 32863298 | Despite persistent anticoagulant therapy, the patient’s arterial thrombosis continued to progress and presented with ischemic necrosis of the lower extremity. | 2020-09-01 |
| 32863462 | This study examines an unexplored consequence of COVID-19 school closures: the broken link between child maltreatment victims and the number one source of reported maltreatment allegations-school personnel. […] Using current, county-level data from Florida, we estimate a counterfactual distribution of child maltreatment allegations for March and April 2020, the first two months in which Florida schools closed. […] While one would expect the financial, mental, and physical stress due to COVID-19 to result in additional child maltreatment cases, we find that the actual number of reported allegations was approximately 15,000 lower (27%) than expected for these two months. | 2020-09-01 |
| 32863555 | Several months after its discovery and despite its pandemic spread, there are still many grey areas concerning the pathophysiology and treatment of COVID-19. | 2020-09-01 |
| 32863593 | The long-term effects of healthcare reshuffling in the “COVID-19 era” imply a delay in the diagnosis and treatment of skin cancer and cancellation of many reconstructive procedures. | 2020-09-01 |
| 32863637 | A subset of serious COVID-19 patients with serious acute respiratory illness may be triaged not to receive aggressive intensive care unit (ICU) treatment and ventilation or may be discontinued from ventilation due to their underlying conditions. […] The family should be sensitively communicated about the futility of ICU measures and foregoing life-sustaining treatment. […] Family meeting outcomes are documented, and consent for foregoing life-sustaining treatment is obtained. | 2020-09-01 |
| 32863675 | In this review we have analyzed that the COVID-19 has analogy with the Rajayakshma (∼a wasting disease indicating suboptimum immune response) and the established treatment of Rajayakshma disease can be proposed for preventive as well as curative purpose. | 2020-09-01 |
| 32863676 | The prime of COVID-19 forced institutions and hospitals to convert operating rooms into intensive care units. | 2020-09-01 |
| 32863755 | Currently there is no effective treatment for coronavirus infection; major effort is to develop vaccine against the virus and development of therapeutic drugs for the disease. | 2020-09-01 |
| 32863810 | Rapid detection and point-of-care (POC) analysis of pathogens causing these diseases is not only a problem entailing the scientific community but also raises challenges in tailoring appropriate treatment strategies to the healthcare sector. | 2020-09-01 |
| 32863816 | As an example, the no-show behavior in outpatient departments during the lockdown might have led to a relevant undertreatment of underlying chronic health conditions. | 2020-09-01 |
| 32863871 | This article highlights the unique circumstances and challenges of cancer treatment during this global pandemic and the importance of organisational structure, preparation and a shared vision for continuing to provide cancer treatment to patients in the face of uncertainty and rapid change. | 2020-09-01 |
| 32863879 | Adapting face-to-face physical therapy consultations in cancer care to a model of telerehabilitation has been necessary, given the imminent spread of the COVID-19 pandemic. […] In this respect, the current model of telerehabilitation for people with breast cancer can be described as a method of continuing physical therapy treatment, in a public hospital with limited resources. | 2020-09-01 |
| 32863947 | Nanomedicine-based therapeutics that target macrophages have recently been shown to reduce cytokine production in animal models of diseases that are associated with excessive proinflammatory responses. | 2020-09-01 |
| 32864068 | Effective management of conjunctivitis includes timely diagnosis, appropriate differentiation of the various etiologies, and appropriate treatment. | 2020-09-01 |
| 32864162 | We also describe the complexity of the risk for QT prolongation in this setting because of additive effects of combining more than one QT-prolonging drug (i.e., hydroxychloroquine/chloroquine and azithromycin), increased concentrations of the drugs due to genetic variants, along with the risk of also combining therapy with potent inhibitors. | 2020-09-01 |
| 32864178 | Therefore, multidisciplinary teams (MDTs) and individualized treatment plans, accurate prediction of disease progression and timely interventions are vital to effectively reduce mortality. […] The treatment plan complies with three principles, namely, multidisciplinary management of patients, individualized diagnosis and treatment plans, and timely monitoring and intervention of disease. […] According to a patient’s specific disease condition, an individualized diagnosis and treatment plan is formulated (one plan for one patient). […] While selecting individualized antiviral, anti-inflammatory and immunomodulatory treatment, we also strengthen nutritional support, psychological intervention, comprehensive rehabilitation and timely and full-course intervention to develop overall and special nursing plans. […] Therefore, a multidisciplinary, three-dimensional and individualized comprehensive treatment plan can effectively reduce the mortality rate of severe/critical COVID-19 and improve the cure rate. | 2020-09-01 |
| 32864192 | This was a Spanish transplant group and cell therapy (GETH) multicenter retrospective observational study, which included a large cohort of blood cancer patients with laboratory-confirmed SARS-CoV-2 infection through PCR assays from March 1st 2020 to May 15th 2020. […] In multivariate analysis of 216 patients with very severe COVID-19, treatment with azithromycin or low dose corticosteroids was associated with lower OM (OR 0.42, 95% CI 0.2-0.89 and OR 0.31, 95% CI 0.11-0.87, respectively, p = 0.02) whereas the use of hidroxycloroquine did not show significant improvement in OM (OR 0.64, 95% CI 0.37-1.1, P = 0.1). | 2020-09-01 |
| 32864235 | Patients that were hospitalized for acute presentation of COVID-19 infection should reasonably be considered for extended anticoagulant therapy after discharge. | 2020-09-01 |
| 32864265 | We highlight the successful use of half-dose anticoagulation in the treatment of right atrial thrombus in a patient with COVID-19. | 2020-09-01 |
| 32864270 | Such a tool can gauge the severity of COVID-19 lung infections (and pneumonia in general) that can be used for escalation or de-escalation of care as well as monitoring treatment efficacy, especially in the ICU. […] Conclusions These results indicate that our model’s ability to gauge the severity of COVID-19 lung infections could be used for escalation or de-escalation of care as well as monitoring treatment efficacy, especially in the ICU. | 2020-09-01 |
| 32864332 | However, the promotion of LH for the treatment of patients with COVID-19 remains controversial. […] Compared with patients treated by conventional treatment, patients treated by LH combined with conventional treatment have a higher overall effective rate (RR = 1.16, 95%CIs: 1.04∼1.30, P = 0.01) and CT recovery rate (RR=1.21, 95%CIs: 1.02∼1.43, P = 0.03). […] But the rate of abnormal liver function in the combined medication group is higher than that in the single LH group. […] LH combined with conventional treatment seems to be more effective for patients with mild or ordinary COVID-19. | 2020-09-01 |
| 32864340 | Empiric systemic antifungal therapy may be justified in selected cases, pending diagnostic work up results. […] Large, multi-center studies are required to further understand the pathogenesis of invasive aspergillosis in COVID-19, and the optimal diagnostic and treatment strategies. | 2020-09-01 |
| 32864352 | Brazil faces some challenges in the battle against the COVID-19 pandemic, including: the risks for cross-infection (community infection) increase in densely populated areas; low access to health services in areas where the number of beds in intensive care units (ICUs) is scarce and poorly distributed, mainly in states with low population density. | 2020-09-01 |
| 32864373 | Due to increasing cases globally with COVID-19, there is an urgent requirement to develop an ideal vaccine and antiviral therapy against this virus to control the disease worldwide. | 2020-09-01 |
| 32864402 | The data could be used to validate the anti-viral role of the predicted miRNAs and design miRNA-based therapeutics against SARS-CoV-2. | 2020-09-01 |
| 32864509 | COVID-19 drug and vaccine trials are even now making use of accelerated drug approval programs, blended trials, and adaptive trial design to accelerate approval of therapeutics in the pandemic. | 2020-09-01 |
| 32864514 | No patients received antiviral medication or hydroxychloroquine. 21 patients (20%) were admitted at COVID-19 diagnosis. 29 of 85 patients (34%) were admitted after initial outpatient management. 16 patients (15%) died. | 2020-09-01 |
| 32864570 | To determine changes in clinical and radiologic findings associated with Coronavirus disease 2019 (COVID-19) from diagnosis to recovery, we retrospectively reviewed the diagnosis and treatment records of the first patient cured of COVID-19 in Guangzhou. […] COVID-19 was laboratory confirmed by reverse transcription polymerase chain reaction (RT-PCR) assay, and she received conventional antiviral therapy, such as moxifloxacin, traditional Chinese medicine, and arbidol. | 2020-09-01 |
| 32864571 | While remdesivir has proven to be a safe medication generally, we here have enlisted the potential interactions of remdesivir that a clinician needs to be mindful of while prescribing the medication. | 2020-09-01 |
| 32864572 | Since SARS-CoV-2 is a novel virus, little is known about it and no effective drug is available for its treatment. […] We presume that restoration of normal functioning of renin-angiotensin system with recombinant human angiotensin-converting enzyme 2 (rhACE2), angiotensin (1-7) and angiotensin (1-9) may be an effective therapeutic measure but studies will be required to test this hypothesis and explore its possible role in treatment of COVID-19. | 2020-09-01 |
| 32864575 | Although frantic global efforts for developing safe and effective prophylactic and therapeutic agents are on, no licensed antiviral treatment or vaccine exists till date. | 2020-09-01 |
| 32864576 | We present a case of a 66-year-old woman with severe pneumonia by SARS-CoV-2 who developed a posterior reversible encephalopathy syndrome with a typical clinical and radiological presentation, after being treated with anti-interleukin treatment (anakinra and tocilizumab) following local guidelines. | 2020-09-01 |
| 32864588 | We compared clinical presentation, diagnostics, treatment, and outcomes. | 2020-09-01 |
| 32864590 | We retrospectively analyzed this cohort of 117 discharged patients and analyzed the differences between retest positive and negative patients in terms of demographics, clinical characteristics, laboratory findings, chest computed tomography (CT) features and treatment procedures. […] Compared with the negative group, the positive group had a higher proportion of patients with comorbidities (Odds Ratio(OR) =2·12, 95% Confidence Interval(CI) 0·48-9·46; p = 0·029), longer hospital stay (OR=1·21, 95% CI 1·07-1·36; p = 0·008), a higher proportion of patients with lymphocytopenia (p = 0·036), a higher proportion of antibiotics treatment (p = 0·008) and glucocorticoids treatment (p = 0·003). | 2020-09-01 |
| 32864601 | The COVID-19 pandemic has modified practice for patients with symptomatic aortic stenosis and could result in higher mortality due to treatment delays. | 2020-09-01 |
| 32864608 | To assess the rate of empirical antimicrobial treatment in COVID-19 cases, assess the rate and methods of microbiological sampling, assess the rate of bacterial respiratory coinfections and evaluate the factors associated with antimicrobial therapy in this cohort. […] A total of 117 patients were recruited; 84 (72%) were prescribed antimicrobial therapy for lower respiratory tract infections. […] The median duration of antimicrobial therapy was 7 days. […] C-reactive protein level, oxygen requirement and positive cultures were associated with prolonged duration of therapy. […] Despite this, prolonged courses of antimicrobial therapy were prescribed in our cohort. | 2020-09-01 |
| 32864627 | Hydroxychloroquine, a drug commonly used in the treatment of rheumatoid arthritis, has received much negative publicity for adverse events associated with its authorisation for emergency use to treat patients with COVID-19 pneumonia. […] Hydroxychloroquine treatment appears to have no increased risk in the short term among patients with rheumatoid arthritis, but in the long term it appears to be associated with excess cardiovascular mortality. […] We call for careful consideration of the benefit-risk trade-off when counselling those on hydroxychloroquine treatment. | 2020-09-01 |
| 32864735 | During this period of crisis, researchers over the world have ramped their efforts to constrain the disease in all possible ways, whether it is vaccination, therapy or diagnosis. | 2020-09-01 |
| 32864815 | Providing this subtyping information, we hope this review would serve the scientists, clinicians, and the pharmaceutical industry who are looking at the new therapeutics for COVID-19 treatment. | 2020-09-01 |
| 32864934 | Moreover, cardiopulmonary failure refractory to standard treatment may necessitate the use of extreme therapeutic strategies, such as extracorporeal membrane oxygenation. | 2020-09-01 |
| 32865072 | Spontaneous epistaxis in patients with COVID-19 can represent a clinical challenge with respect to both the risk of contamination and the treatment options. […] All patients received low-molecular-weight heparin during their hospital stay and required supplementary oxygen therapy either by a nasal cannula or continuous positive airway pressure. […] If any treatment is required, appropriate self-protection is mandatory. | 2020-09-01 |
| 32865152 | This study provides a basis for comparisons with future studies which could involve new treatment options currently under study. | 2020-09-01 |
| 32865190 | During this pandemic and dramatic emergency, Italian hospitals had also to face neoplastic pathologies, that still afflict the Italian population, requiring urgent surgical and oncological treatment. | 2020-09-01 |
| 32865382 | Although the disease course of coronavirus disease-2019 seems to be mild in children, critical illness is significant, and the treatment strategy primarily should consist of supportive care according to our preliminary observations. | 2020-09-01 |
| 32865490 | In this article, we describe the sequence of pathological changes in COVID-19 and discuss the implications for approaches to treatment. […] Autopsies are crucial for the systematic assessment of new diseases such as COVID-19: they provide a basis for further investigations of disease mechanisms and for the devising of potentially effective modes of treatment. | 2020-09-01 |
| 32865522 | Photobiomodulation therapy (PBMT) is a safe, non-invasive therapy with significant anti-inflammatory effects. […] The patient was evaluated before and after treatment via radiological assessment of lung edema (RALE) by CXR, pulmonary severity indices, blood tests, oxygen requirements, and patient questionnaires. | 2020-09-01 |
| 32865603 | An efficient antiviral therapy is not yet available. […] Severely ill patients may benefit from dexamethasone and early treatment of complications. | 2020-09-01 |
| 32865701 | Convalescent plasma therapy has been implemented in a few cases of severe coronavirus disease 2019. […] No report about convalescent plasma therapy in treating patients with prolonged positivity of SARS-CoV-2 RNA has been published. […] In this study, we conducted a retrospective observational study in 27 patients with prolonged positivity of SARS-CoV-2 RNA, the clinical benefit of convalescent plasma therapy were analyzed. qRT-PCR test of SARS-CoV-2 RNA turned negative (≤ 7 days) in a part of patients (early negative group, n = 15) after therapy, others (late negative group, n = 12) turned negative in more than 7 days. […] Pulmonary imaging improvement was confirmed in 7 patients in early negative group and 8 in late negative group after CP therapy. […] Viral load decreased in early negative group compared with late negative group at day 3, 5, 7 after implementing convalescent plasma therapy. […] In conclusion, convalescent plasma therapy might help eliminate virus and shorten length of hospital stay in patients with prolonged positivity of SARS-CoV-2 RNA. | 2020-09-01 |
| 32865757 | We searched for reviews describing the characteristics of autoimmune diseases and the available therapeutic protocols for their treatment. | 2020-09-01 |
| 32865809 | Having monitored data sequentially from 237 patients, we comment on the strength and weakness of the study design and suggest the treatment effect of remdesivir on severe COVID-19 cases. | 2020-09-01 |
| 32865850 | In particular, providers who treat posttraumatic stress disorder (PTSD) are now tasked with determining whether to initiate trauma-focused therapy during the pandemic and, if so, whether and how to adapt treatment. […] The purpose of this communication is to identify and organize key considerations for whether and how to deliver commonly used evidence-supported therapy protocols for trauma treatment-specifically, cognitive processing therapy (CPT) and prolonged exposure (PE) therapy-during the ongoing COVID-19 pandemic for adults who currently meet the criteria for PTSD. […] Based on relevant public health and clinical literature, we present a structured guide that can be used by treatment teams and individual providers to evaluate whether initiating CPT or PE is indicated given a particular patient-provider pair and system context amidst pandemic conditions. | 2020-09-01 |
| 32866247 | Respondents provided information regarding changes in clinical volume, treatment, and mental health (Patient Health Questionnaire [PHQ-4]) before April 10, 2020. | 2020-09-01 |
| 32866264 | Through the coronavirus disease 2019 (COVID-19) pandemic, telemedicine became a necessary entry point into the process of diagnosis, triage and treatment. | 2020-09-01 |
| 32866312 | The wastewater sector is critical to public health protection and employs collection and treatment system workers who perform tasks with high potential for exposures to biological agents. | 2020-09-01 |
| 32866437 | Due to their central role in immune response against SARS-CoV-2 infection, IFN type I and III could be considered for treatment of COVID-19. | 2020-09-01 |
| 32866640 | To further reveal the phylogenetic evolution and molecular characteristics of the whole genome of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) based on a large number of genomes and provide a basis for the prevention and treatment of SARS-CoV-2. | 2020-09-01 |
| 32866795 | Development of practical guidelines for first-hand response and early treatment of psychosocial aspects of COVID-19 in East Java Province, Indonesia, based on the recommendations of 14 articles related to COVID-19 psychosocial handling was carried out. | 2020-09-01 |
| 32866858 | In this study, infertile couples candidate to ART and whose treatment was blocked due to the COVID-19 lockdown were enrolled through an online survey. | 2020-09-01 |
| 32867244 | This has a number of prophylactic and treatment implications for SARS-CoV-2 infection and cancers and future research directions that better investigate the biological underpinnings of social processes and how these may drive health disparities. | 2020-09-02 |
| 32867260 | Furthermore, regulatory agencies have addressed various approaches toward these products, whether they authorize claims mentioning a disease’s diagnosis, prevention, or treatment. […] One of the novelties of this review is the presentation of the beneficial effects of the administration of probiotics as a potential adjuvant therapy in COVID-19. | 2020-09-02 |
| 32867585 | Additionally, telemedicine can be positively integrated into the treatment of otolaryngology diseases for new and established patients. | 2020-09-02 |
| 32867623 | Although European governments have launched the so-called phase 2 in the coronavirus disease 2019 (COVID-19) pandemic (a transitional phase of beginning to downsize containment measures), intensive care units are not COVID-19-free and this restricts our therapeutic strategies. | 2020-09-02 |
| 32867625 | Our data demonstrated that SARS-CoV-2 has infected cats in Wuhan during the outbreak and described serum antibody dynamics in cats, providing an important reference for clinical treatment and prevention of COVID-19. | 2020-09-02 |
| 32867645 | To spot the novel antiviral therapy is of decisive importance and Mother Nature is an excellent source for such discoveries. | 2020-09-02 |
| 32867651 | Currently, several repurposing strategies are under different phases of clinical trials and provide with definitive framework for the development of future therapies for the effective treatment of COVID-19. […] This review article summarizes the latest developments and trends in drug repurposing strategy for COVID-19 treatment. | 2020-09-02 |
| 32867652 | Current treatment relies mainly on self-recovery through patients’ immune function. | 2020-09-02 |
| 32867666 | We highlighted potential approaches to address the antiviral therapy inhibiting the replication of SARS-CoV-2 in the host targeting (a.) […] The recently exercised immuno-enhancement therapy to fight against SARS-CoV-2 and treatment strategy using drug combination are also explored here in this review. | 2020-09-02 |
| 32867852 | We will also evaluate a number of secondary outcomes, including hospitalization related to suspected/confirmed COVID-19 infection, intensive care unit or high-dependency unit admission due to suspected/confirmed COVID-19 infection, all-cause mortality, need for organ support (non-invasive or invasive ventilation, vasopressors and renal replacement therapy), ICU and hospital length of stay, readmission, days off work and treatment-related adverse events. […] Allocation concealment is maintained by central web-based randomisation BLINDING (MASKING): This is an unblinded study: study assigned treatment will be known to the research team and participant. […] This sample size allows for a potential loss to follow-up rate of 10% and a potential non-compliance rate of 10% in both the treatment and control arms. | 2020-09-02 |
| 32867855 | The main topics highlighted are general recommendations, pulmonary complications, drug treatment, trauma, pregnancy, children and elderly people, and patient associations role. | 2020-09-02 |
| 32867874 | Non-essential services were eliminated but in-patient treatment of psychiatric illnesses was necessarily maintained. | 2020-09-02 |
| 32868092 | The complex virology of COVID-19 may provide multiple potential target points for antiviral therapy, and vaccines; extensive global research is underway to exploit these potential opportunities. […] Non medication based interventions including hyperbaric oxygen (HBOT), extracorporeal membrane oxygenation (ECMO), aggressive dialysis, and other interventions, all with various degrees of clinical success, and will be discussed in this section. […] In addition to therapeutics, concern was raised over potential risks associated with ACE inhibitors and ARB use, which is presented. […] Often the timing of the medication determined its clinical benefit as will be discussed with dexamethasone and other medications. […] As such, this Therapeutics Review will present prominent and/or promising medications and therapeutic approaches with the caveats that 1. […] Recognizing the knowledge basis upon which we treat COVID-19 patients, develop therapeutics, and vaccines continues to evolve as new information is presented, every effort nevertheless has been made to provide as timely information as possible. | 2020-09-02 |
| 32868142 | Since most recovery housing operates outside formal substance use treatment, residents who pay out-of-pocket for services largely support these residences. | 2020-09-02 |
| 32868252 | Several recommendation documents were published at the beginning of the pandemic, but as the situation evolves, our thoughts should not only focus on the present, but should also reflect on how we are going to deal with the presence of the virus in the community until there is a vaccine or specific treatment available. | 2020-09-02 |
| 32868252 | Several recommendation documents were published at the beginning of the pandemic, but as the situation evolves, our thoughts should not only focus on the present, but should also reflect on how we are going to deal with the presence of the virus in the community until there is a vaccine or specific treatment available. | 2020-09-02 |
| 32868252 | Several recommendation documents were published at the beginning of the pandemic, but as the situation evolves, our thoughts should not only focus on the present, but should also reflect on how we are going to deal with the presence of the virus in the community until there is a vaccine or specific treatment available. | 2020-09-02 |
| 32868252 | Several recommendation documents were published at the beginning of the pandemic, but as the situation evolves, our thoughts should not only focus on the present, but should also reflect on how we are going to deal with the presence of the virus in the community until there is a vaccine or specific treatment available. | 2020-09-02 |
| 32868252 | Several recommendation documents were published at the beginning of the pandemic, but as the situation evolves, our thoughts should not only focus on the present, but should also reflect on how we are going to deal with the presence of the virus in the community until there is a vaccine or specific treatment available. | 2020-09-02 |
| 32868252 | Several recommendation documents were published at the beginning of the pandemic, but as the situation evolves, our thoughts should not only focus on the present, but should also reflect on how we are going to deal with the presence of the virus in the community until there is a vaccine or specific treatment available. | 2020-09-02 |
| 32868252 | Several recommendation documents were published at the beginning of the pandemic, but as the situation evolves, our thoughts should not only focus on the present, but should also reflect on how we are going to deal with the presence of the virus in the community until there is a vaccine or specific treatment available. | 2020-09-02 |
| 32868252 | Several recommendation documents were published at the beginning of the pandemic, but as the situation evolves, our thoughts should not only focus on the present, but should also reflect on how we are going to deal with the presence of the virus in the community until there is a vaccine or specific treatment available. | 2020-09-02 |
| 32868252 | Several recommendation documents were published at the beginning of the pandemic, but as the situation evolves, our thoughts should not only focus on the present, but should also reflect on how we are going to deal with the presence of the virus in the community until there is a vaccine or specific treatment available. | 2020-09-02 |
| 32868252 | Several recommendation documents were published at the beginning of the pandemic, but as the situation evolves, our thoughts should not only focus on the present, but should also reflect on how we are going to deal with the presence of the virus in the community until there is a vaccine or specific treatment available. | 2020-09-02 |
| 32868252 | Several recommendation documents were published at the beginning of the pandemic, but as the situation evolves, our thoughts should not only focus on the present, but should also reflect on how we are going to deal with the presence of the virus in the community until there is a vaccine or specific treatment available. | 2020-09-02 |
| 32868252 | Several recommendation documents were published at the beginning of the pandemic, but as the situation evolves, our thoughts should not only focus on the present, but should also reflect on how we are going to deal with the presence of the virus in the community until there is a vaccine or specific treatment available. | 2020-09-02 |
| 32868252 | Several recommendation documents were published at the beginning of the pandemic, but as the situation evolves, our thoughts should not only focus on the present, but should also reflect on how we are going to deal with the presence of the virus in the community until there is a vaccine or specific treatment available. | 2020-09-02 |
| 32868252 | Several recommendation documents were published at the beginning of the pandemic, but as the situation evolves, our thoughts should not only focus on the present, but should also reflect on how we are going to deal with the presence of the virus in the community until there is a vaccine or specific treatment available. | 2020-09-02 |
| 32868252 | Several recommendation documents were published at the beginning of the pandemic, but as the situation evolves, our thoughts should not only focus on the present, but should also reflect on how we are going to deal with the presence of the virus in the community until there is a vaccine or specific treatment available. | 2020-09-02 |
| 32868252 | Several recommendation documents were published at the beginning of the pandemic, but as the situation evolves, our thoughts should not only focus on the present, but should also reflect on how we are going to deal with the presence of the virus in the community until there is a vaccine or specific treatment available. | 2020-09-02 |
| 32868260 | Of note, SGH reorganised operating procedures and physical spaces to meet national standards of safe physical distancing, restricted movement between treatment areas and teams, and rosters to remain committed to the supervision and education of students. | 2020-09-02 |
| 32868279 | The established processes for ensuring safe outpatient surveillance of patients with known heart valve disease (HVD), echocardiography for patients referred with new murmurs and timely delivery of surgical or transcatheter treatment for patients with severe disease have all been significantly impacted by the novel coronavirus pandemic. […] This has created a large backlog of work and upstaging of disease with consequent increases in risk and cost of treatment and potential for worse long-term outcomes. […] Local procedural waiting times will need to be considered, in addition to usual clinical characteristics in determining whether patients requiring intervention would be better suited having surgical or transcatheter treatment. | 2020-09-02 |
| 32868327 | In intensive care unit (ICU) settings, in which multiple-organ dysfunctions can occur rapidly, hemodialysis may be a viable option for maintaining remdesivir treatment, while improving tolerance, by removing both remdesivir’s metabolite (GS-441524) and sulfobutylether β-cyclodextrin sodium (SEBCD). | 2020-09-02 |
| 32868681 | To describe how the novel coronavirus (COVID-19) pandemic has affected opioid agonist treatment (OAT) programs in jails and prisons. […] In May 2020, we conducted an online survey of 19 carceral systems that provided methadone and/or buprenorphine treatment for incarcerated populations before COVID-19. […] Seven of 16 systems made changes to medication dispensation processes. […] Given the robust evidence base around OAT for treating opioid use disorder and averting overdose deaths, guidance is needed on maintaining and ramping up medication access as carceral facilities grapple with implementing COVID-19 mitigation. | 2020-09-02 |
| 32868801 | Several drug candidates have been proposed and tested as the latest clinical treatment for coronavirus pneumonia (COVID-19). […] Chloroquine, hydroxychloroquine, ritonavir/lopinavir, and favipiravir are under trials for the treatment of this disease. | 2020-09-02 |
| 32868970 | At present, no vaccine or specific drug is on hand for the treatment of this infectious disease. […] Adjuvant/supportive care therapy are used in patients to get the best results in order to minimize the short and long-term complications. | 2020-09-02 |
| 32868974 | A 51- year old male, with no prior medical history, no medication, and non-smoker arrived at the emergency department with exercise induced dyspnea during 4-5 weeks and for the last 48 h dyspnea at rest. | 2020-09-02 |
| 32868977 | While the literature recommends the use of multidisciplinary teams in the management of patients with tracheostomy for other diseases, little is known on the collaborative administration of physical therapy and speech language pathology services in the COVID-19 population. […] We sought to determine the outcomes of a collaboration between physical therapy (PT) and speech language pathology (SLP) in the treatment of patients who underwent tracheostomy placement as part of their treatment for COVID-19 at our facility. […] Patient participation in therapy sessions improved following establishment of oral verbal communication. […] Interdisciplinary cooperation and synchronized implementation of PT and SLP interventions in three COVID-19 patients following prolonged intubation facilitated participation in treatment and achievement of functional milestones. | 2020-09-02 |
| 32868983 | Although many forces are speeding up to develop prevention and treatment therapeutics, it is unlikely that any de novo drugs will be available in months. | 2020-09-02 |
| 32868989 | Use of systemic corticosteroids for the treatment for coronavirus disease 2019 (COVID-19) among chronic obstructive pulmonary disease (COPD) patients is not well described. […] Combination treatment of short-course systemic corticosteroid and favipiravir might improve the prognosis for critically ill COVID-19 pneumonia with COPD without negative influence on viral clearance or antibody production. | 2020-09-02 |
| 32869251 | Under these unique circumstances, urologists continue to provide essential healthcare services and support healthcare systems, by participating in the treatment of COVID-19(+) patients and sparing vital equipment and hospital beds. | 2020-09-02 |
| 32869556 | Severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) infection is not differentiated clinically from other respiratory infections, and intensive care units (ICUs) are vulnerable to in-hospital transmission due to interventions inducing respiratory aerosols. | 2020-09-02 |
| 32869558 | Coronaviruses have caused serious Severe Acute Respiratory Syndrome (SARS), Middle East Respiratory Syndrome (MERS), and Coronavirus Disease 2019 (COVID-19) outbreaks, and only remdesivir has been recently indicated for the treatment of COVID-19. […] In the line of therapeutic options for SARS and MERS, this study aims to summarize the current clinical evidence of treatment options for COVID-19. […] In general, the combination of antibiotics, ribavirin, and corticosteroids was considered as a standard treatment for patients with SARS. […] The addition of this conventional treatment with lopinavir/ritonavir, interferon, and convalescent plasma showed potential clinical improvement. […] Among antibiotics for infection therapy, azithromycin was suggested. […] In conclusion, this study showed the up-to-date evidence of treatment options for COVID-19 that is helpful for the therapy selection and the development of further guidelines and recommendations. | 2020-09-02 |
| 32869768 | This commentary (i) focuses on Ramazzini’s xiii oration describing that event, (ii) analyses the approach suggested to fight the cattle epidemic and economic threats, (iii) highlights some similar aspects between the 1711 rinderpest epidemic and the current COVID-19 pandemic (team expertise, contagion transmissibility, drug treatment, preventive measures, decision timeliness). | 2020-09-02 |
| 32869769 | The risk of transmission of COVID-19 or other serious respiratory infections during a pandemic event can dissuade lay rescuers from practicing resuscitation maneuvers; this may result in a reduction in efficacy in the treatment of the subject with cardiorespiratory arrest; this can also happen in occupational settings for the “designed first aid worker”. | 2020-09-02 |
| 32869962 | This paper is the first update of the second edition of the rapid living systematic review on the latest scientific literature informing rehabilitation of patients with COVID-19 and/or describing consequences of the disease and its treatment, as they relate to limitations in functioning of rehabilitation interest. | 2020-09-02 |
| 32870351 | However, the studies of pathogen (bacteria/virus)-host cell interactions mediated by membrane protein interactions did not extend their principles to broad biomedical applications such as 2019-nCoV infectious disease therapy. […] Taken together, the combined overview of two of the most innovative and exciting developments in the immunoinflammatory field provides new insight into high-throughput construction of ultrasensitive cytokine and virion liquid chips for HTS of anti-inflammatory drugs or clinical diagnosis and treatment of inflammatory diseases including infectious diseases, acute or chronic inflammation (acute gouty arthritis or rheumatoid arthritis), cardiovascular disease, atheromatosis, diabetes, obesity, tissue injury and tumors. […] It has significant value in the prevention and treatment of these serious and painful diseases. | 2020-09-02 |
| 32870376 | Statins are first-line therapy for lowering low-density lipoprotein (LDL) cholesterol in familial hypercholesterolemia (FH), particularly in heterozygous patients. […] Cumulative evidence from registry data and sub-analyses of clinical trials mandates the value of statin therapy for prevention of atherosclerotic cardiovascular disease (ASCVD) in FH. […] FH is undertreated, with > 80% of statin-treated FH patients failing to attain LDL cholesterol treatment targets. […] Statin treatment from childhood may reduce the need for stringent cholesterol targets. […] Combination of statins with ezetimibe and PCSK9 inhibitors significantly improves the efficacy of treatment. […] Sustained long-term optimal statin treatment from an early age can effectively prevent ASCVD over decades of life. | 2020-09-02 |
| 32870407 | To date, no therapy has demonstrated efficacy in COVID-19. | 2020-09-02 |
| 32870433 | It also appears to lack a significant risk of drug-drug interactions with therapeutics currently being evaluated for COVID-19. | 2020-09-02 |
| 32870481 | Having demonstrated potent antiviral activity against coronaviruses in preclinical studies, remdesivir emerged as a candidate drug for the treatment of the novel coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, during the current global pandemic. […] Phase III evaluation of remdesivir in the treatment of COVID-19 commenced in early 2020 and has thus far yielded promising results. […] This article summarizes the milestones in the development of remdesivir leading to its first conditional approval for the treatment of COVID-19. | 2020-09-02 |
| 32870512 | An up-to-date understanding of how best to target this therapy (e.g. arterial partial pressure of oxygen (PaO2) or peripheral oxygen saturation (SpO2) aim) in these patients is urgently required. […] To address how oxygen therapy should be targeted in adults with ARDS (particularly ARDS secondary to COVID-19 or other respiratory viruses) and requiring mechanical ventilation in an intensive care unit, and the impact oxygen therapy has on mortality, days ventilated, days of catecholamine use, requirement for renal replacement therapy, and quality of life. […] We used the GRADE approach to judge the certainty of the evidence for the following outcomes; mortality at longest follow-up, days ventilated, days of catecholamine use, and requirement for renal replacement therapy. […] The study randomized 205 mechanically ventilated patients with ARDS to either conservative (PaO2 55 to 70 mmHg, or SpO2 88% to 92%) or liberal (PaO2 90 to 105 mmHg, or SpO2 ≥ 96%) oxygen therapy for seven days. […] There was no evidence of a difference between the lower and higher target groups in mean number of days ventilated (14.0, 95% CI 10.0 to 18.0 versus 14.5, 95% CI 11.8 to 17.1); number of days of catecholamine use (8.0, 95% CI 5.5 to 10.5 versus 7.2, 95% CI 5.9 to 8.4); or participants receiving renal replacement therapy (13.7%, 95% CI 5.8% to 21.6% versus 12.0%, 95% CI 5.0% to 19.1%). | 2020-09-02 |
| 32870698 | It is intended to assist dental professionals in providing accurate, current information in answer to patients’ questions regarding testing and treatment. | 2020-09-02 |
| 32870735 | Many clinical trials are underway globally to delineate the role of vitamin D in both prevention and treatment of COVID-19. | 2020-09-02 |
| 32870738 | To describe the prevalence of ocular features among COVID-19 patients and their relationship with clinical data, inflammatory markers and respiratory support therapy (including CPAP); to investigate SARS-CoV-2 in ocular secretions of symptomatic patients. […] Ocular manifestations in hospitalized COVID-19 patients can also be a consequence of respiratory support therapy. | 2020-09-02 |
| 32870787 | Critical care ultrasound (CCUS) can rapidly acquire the image of lung and other organs and demonstrate the pathophysiological changes to guide precise therapy in COVID-19 pneumonia without radiation or interfering with personal protective equipment. […] In addition, the application of CCUS can cover the whole courses from the fever clinic to the intensive care unit to improve the treatment. | 2020-09-02 |
| 32870820 | Of particular importance is the identification of immune correlates of infection that would support public health decision-making on treatment approaches, vaccination strategies, and convalescent plasma therapy. | 2020-09-02 |
| 32871014 | Data were collected on age, sex, physical ability, rehabilitation modality (remote/direct), need for intubation or extracorporeal membrane oxygenation, degree of pneumonia, oxygen therapy from the start of rehabilitation, D-dimer and C-reactive protein levels, and rehabilitation-related complications. | 2020-09-02 |
| 32871151 | As there is no vaccine and appropriate drugs for treatment of the novel Coronavirus Disease (COVID-19), one of the fundamental problems is the evaluation of environmental and social weaknesses of cities/regions to the exposure of infectious diseases for preventing and/or containing new COVID-19 outbreaks and of other viral agents that generate negative impact on public health and economy of countries. | 2020-09-02 |
| 32871183 | Tocilizumab treatment caused an increase of IL-17A in 3/6 patients and a reduction in 3 others, while the lymphocyte number increased in 3 patients and did not change in the others. […] The increase of TH17 and IL-17 in a subset of cases and the evidence of a significant increase of IL-17RA (that prevents the interaction of IL-17 with the cell receptor) in patients with low severity suggest that some patients could benefit from monoclonal antibodies treatment targeting IL-17 pathway. […] Immunocytofluorimetric markers may contribute to a personalized therapy in COVID patients. | 2020-09-02 |
| 32871238 | We therefore evaluated the effect of calcifediol treatment, on Intensive Care Unit Admission and Mortality rate among Spanish patients hospitalized for COVID-19. […] All hospitalized patients received as best available therapy the same standard care, (per hospital protocol), of a combination of hydroxychloroquine (400 mg every 12 h on the first day, and 200 mg every 12 h for the following 5 days), azithromycin (500 mg orally for 5 days. […] Patients in the calcifediol treatment group continued with oral calcifediol (0.266 mg) on day 3 and 7, and then weekly until discharge or ICU admission. […] Univariate Risk Estimate Odds Ratio for ICU in patients with Calcifediol treatment versus without Calcifediol treatment: 0.02 (95 %CI 0.002-0.17). […] Multivariate Risk Estimate Odds Ratio for ICU in patients with Calcifediol treatment vs Without Calcifediol treatment ICU (adjusting by Hypertension and T2DM): 0.03 (95 %CI: 0.003-0.25). […] Our pilot study demonstrated that administration of a high dose of Calcifediol or 25-hydroxyvitamin D, a main metabolite of vitamin D endocrine system, significantly reduced the need for ICU treatment of patients requiring hospitalization due to proven COVID-19. | 2020-09-02 |
| 32871242 | Of all patients, including those with Do Not Resuscitate directives, receiving the dual-histamine receptor blockade for at least 48 h, the combination drug treatment resulted in a 16.4% rate of intubation, a 7.3% rate of intubation after a minimum of 48 h of treatment, a 15.5% rate of inpatient mortality, and 11.0 days duration of hospitalization. | 2020-09-02 |
| 32871264 | In 2017, the American Orthopaedic Association advocated for the increased use of telehealth as an assessment and treatment platform, and demand has significantly increased during the COVID 19 pandemic. | 2020-09-02 |
| 32871412 | Several studies have been performed, focusing on understanding the acute respiratory syndrome and treatment strategies. | 2020-09-02 |
| 32871558 | Hematopoietic growth factors, including erythrocyte stimulating agents (ESAs), granulocyte colony-stimulating factors, and thrombopoietin mimetics, can mitigate anemia, neutropenia, and thrombocytopenia resulting from chemotherapy for the treatment of cancer. | 2020-09-02 |
| 32871594 | Treatment, including lopinavir/ritonavir, hydroxychloroquine and corticosteroids, was administered in 23% of patients. | 2020-09-02 |
| 32871607 | Pharmacological targeting of the MBL pathway could be a novel treatment option for thrombosis in COVID-19. | 2020-09-02 |
| 32871661 | Considering the negative impact of depression on quality of patient care and nurses’ QOL, a heightened awareness of, and early treatment for depression for frontline ED nurses should be provided. | 2020-09-03 |
| 32871846 | Clinical trials now underway should determine whether ivermectin is an effective treatment for SARS-Cov2 infection. | 2020-09-03 |
| 32871887 | The objective of this study was to investigate the risk factors for in-hospital mortality in patients with COVID-19, so as to provide a reference for the early diagnosis and treatment.This study retrospectively enrolled 118 patients diagnosed with COVID-19, who were admitted to Eastern District of Renmin Hospital of Wuhan University from February 04, 2020 to March 04, 2020. | 2020-09-03 |
| 32871892 | At present, there are many controversies about whether angiotensin-converting enzyme inhibitors/angiotensin receptor blockers (ACEI/ARB) should be used in the treatment of patients with diabetes mellitus and COVID-19 comorbidities. […] This study will provide a high-quality synthesis of efficacy and safety of ACEI/ARB drugs in patients with COVID-19 combined with diabetes mellitus, providing evidence for clinical treatment of diabetes mellitus combined with COVID-19. | 2020-09-03 |
| 32871900 | Their respiratory symptoms were deteriorating even after initiating treatment with antiviral drugs. | 2020-09-03 |
| 32871931 | At present, there is still no effective treatment for this disease. […] This analysis will further improve the treatment of asymptomatic COVID-19. | 2020-09-03 |
| 32871977 | The aim of this systematic review and meta-analysis is to assess effectiveness and safety of Chinese medicine (CM) as complementary therapy in treating coronavirus disease 2019 (COVID-19). […] This systematic review findings will summarize up-to-date evidence for that CM is more effective and safe as adjunctive treatment for patients with COVID-19. | 2020-09-03 |
| 32871986 | All of them received antifungal treatment for the oral candidiasis and topic cream for diaper erythema. | 2020-09-03 |
| 32871990 | Chinese traditional medicine prescription OUTCOMES:: Following treatment, signs of pneumonia on computed tomography scans were observed to be partially absorbed, and 2 consecutive rounds of nucleic acid amplification testing of swab samples were negative. | 2020-09-03 |
| 32872009 | This systematic review will evaluate the existing evidence of pediatric massage therapy for restoring pediatric lung function from COVID-19. […] This proposed systematic review will evaluate the existing evidence and explore the potential role of pediatric massage therapy on the effectiveness and safety in pulmonary function of COVID-19 convalescent children. | 2020-09-03 |
| 32872017 | This systematic review and meta-analysis will compare the primary and secondary outcomes at baseline and endpoint in the treatment and control groups to investigate the efficacy and safety of LQ for treatment COVID-2019. | 2020-09-03 |
| 32872186 | In the current worldwide pandemic situation caused by the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) and the newest coronavirus disease (COVID-19), therapeutics and prophylactics are urgently needed for a large population. […] Chicken IgY has been widely explored as a clinical anti-infective material for prophylaxis, preventive medicine, and therapy of infectious diseases. […] Moreover, passive immunization with avian antibodies could become an effective alternative therapy, as these can be obtained relatively simply, cost-efficiently, and produced on a large scale. […] Here, we highlight the potential use of polyclonal avian IgY antibodies as an oral prophylactic treatment for respiratory viral diseases, such as COVID-19, for which no vaccine is yet available. | 2020-09-03 |
| 32872217 | Currently, no specific therapies are available, and investigations into the treatment of COVID-19 are lacking. | 2020-09-03 |
| 32872332 | The treatment of SEB-mediated ARDS mice with THC led to a 100% survival, decreased lung inflammation, and the suppression of cytokine storm. […] A transcriptomic analysis of immune cells from the lungs revealed an increase in mitochondrial respiratory chain enzymes following THC treatment. | 2020-09-03 |
| 32872395 | There are currently no promising therapy strategies for either the treatment or prevention of novel coronavirus disease 2019 (COVID-19), despite the urgent need. […] In light of this, we hypothesise that a natural-mineral-based novel nanomaterial, which was developed based on NO therapy, might be a viable strategy for the treatment and prevention of COVID-19. | 2020-09-03 |
| 32872421 | The COVID-19 pandemic has inevitably caused those involved in cancer care to change clinical practice in order to minimize the risk of infection while maintaining cancer treatment as a priority. […] Delaying unnecessary treatment, minimizing toxicity, and identifying care priorities for surgery, radiotherapy, and systemic therapies must be viewed as basic priorities in the COVID-19 era. | 2020-09-03 |
| 32872607 | Treatment decisions for both early and advanced genitourinary (GU) malignancies take into account the risk of dying from the malignancy as well as the risk of death due to other causes such as other co-morbidities. | 2020-09-03 |
| 32872629 | We evaluated the association between treatment with hydroxychloroquine and/or azithromycin and hospital mortality as the primary outcome. […] After the adjusted analysis, azithromycin alone was associated with lower mortality (OR 0.60, 95% CI 0.42-0.85) compared to no treatment. | 2020-09-03 |
| 32872734 | Medical records with clinical characteristics, laboratory data, treatment course, and clinical outcomes were compared based on the presence or absence of diarrhea. | 2020-09-03 |
| 32872738 | Simultaneously strengthening healthcare capacity to endure the peak demand and smart strategies to sustain social distancing and public hygiene are necessary until the effective and safe therapeutics and vaccines against COVID-19 are available. | 2020-09-03 |
| 32873103 | Adult patients with a confirmed diagnosis of COVID-19 admitted to one of the health system’s intensive care units and requiring mechanical ventilation between March 9, 2020 and April 1, 2020, were included in this observational cohort study. | 2020-09-03 |
| 32873106 | Mental health concerns and treatment usually take a backseat when the limited resources are geared for pandemic containment. | 2020-09-03 |
| 32873147 | Angiotensin Converting Enzyme (ACE) inhibitors are widely used as a first line medication for the treatment of hypertension in the UK, although their use was suggested in early reports to increase the risk associated with SARS-CoV-2 infection. | 2020-09-03 |
| 32873175 | Repurposing of safer, established medications that may have antiviral activity is a possible approach for treatment of earlier-stage disease. […] No safety issues were noted with use of doxycycline.Doxycycline is an attractive candidate as a repurposed drug in the treatment of COVID-19 infection, with an established safety profile, strong preclinical rationale, and compelling initial clinical experience described here.The reviews of this paper are available via the supplemental material section. | 2020-09-03 |
| 32873185 | Here we describe the screening of the DrugBank database, a public repository for small molecule therapeutics, to identify approved or experimental phase drugs that can be repurposed against the main protease of SARS-CoV-2. | 2020-09-03 |
| 32873269 | Besides, a proportion of 0.1% patients were admitted to intensive care units (0, 95% CI: 0.000-0.013) and four deaths were reported (0, 95% CI: 0.000-0.000). | 2020-09-03 |
| 32873322 | A pronounced polarization of healthcare resources and workforce towards the prevention of the rapid spread of SARS-CoV-2 occurred at the expenses of the majority of chronic diseases and cancer, thus jeopardizing continuity of care and therapy outcomes. | 2020-09-03 |
| 32873348 | The key research priority areas are as follows: response of older adults to disease, vaccination, and therapeutics; mental health and isolation; and supportive care environments. | 2020-09-03 |
| 32873358 | While most research focuses on the clinical treatment of COVID-19, fewer studies have investigated individuals’ responses towards this novel infectious disease. | 2020-09-03 |
| 32873520 | We explored a link between systemic IL-6, related acute phase proteins and liver injury in hospitalized COVID-19 patients. 655 patients with suspected COVID-19 were screened in the emergency department at the University Hospital of Innsbruck, Austria, between February and April 2020. 96 patients (∼15%) were hospitalized with COVID-19. 15 patients required intensive-care treatment (ICT). | 2020-09-03 |
| 32873575 | Pregnant and recently pregnant women are less likely to manifest covid-19 related symptoms of fever and myalgia than non-pregnant women of reproductive age and are potentially more likely to need intensive care treatment for covid-19. | 2020-09-03 |
| 32873611 | In the absence of an effective and widely available vaccine, it is of paramount importance that we identify risk factors for development of severe symptoms to be able to improve treatment approaches. | 2020-09-03 |
| 32873615 | Due to the COVID-19 pandemic, oncologists have had to balance patients’ need for treatment with their risk of contracting the disease, sometimes leading them to adjust standard treatment and/or rethink its timing. | 2020-09-03 |
| 32873696 | Sigmoidoscopy was recommended prior to escalation to second-line therapy or colectomy. […] In patients requiring second-line therapy, infliximab was considered appropriate irrespective of SARS-CoV-2 status. | 2020-09-03 |
| 32873987 | We looked at patient demographics, fracture types, injury mechanisms, and even changes in treatment protocols. | 2020-09-03 |
| 32874025 | Surgery remains the optimal treatment for the majority of oral malignancies, and primary reconstruction is often necessary to avoid significant morbidity as a result of ablative procedures. | 2020-09-03 |
| 32874417 | These LMICs are already bedeviled weak health systems, ill equipped cancer treatment centers, with outdated machines and grossly inadequate numbers of oncologists required to treat patients with cancer. | 2020-09-03 |
| 32874585 | Inequalities in healthcare provision were identified, emphasising a need for a more cohesive approach to remote treatment across UK healthcare services. […] Positive aspects of technology use were identified but the results suggest a need to address and/or limit the potential for negative impacts of public messages around food and exercise behaviours, and to co-design technologies with end-users to facilitate effective treatment. | 2020-09-03 |
| 32874794 | While the mechanism of agranulocytosis remains unknown, we report, to our knowledge, the first known case of agranulocytosis following COVID-19 infection and its successful treatment with granulocyte colony-stimulating factor. | 2020-09-03 |
| 32874854 | The national government has led in terms of economic and fiscal response, increasing funding for scientific research into testing, treatment, and vaccines, and in creating more favorable regulations for the use of telemedicine. […] State governments have been responsible for many of the containment, testing, and treatment responses, often with little federal government support. | 2020-09-03 |
| 32874856 | The KCDC jointly with medical professionals developed a series of innovations such as 1) Full contact tracing and rapid testing with a 12 hours turnaround and 10 minutes movement tracking systems, 2) transparent disclosure of all contract tracing data to the public through a central database, 3) Drive-Through and Walk-Through testing methods, and 4) a 4 tier patient severity index and community treatment isolation centers. | 2020-09-03 |
| 32874861 | The initial focus was to obtain herd immunity while preventing Intensive Care Units from getting overwhelmed. | 2020-09-03 |
| 32874913 | The aim of this study was to evaluate the clinical efficacy of Xuanfei Baidu Decoction (XBD) combined with conventional drug therapy compared with conventional medicine alone in patients with coronavirus disease 2019 (COVID-19). | 2020-09-03 |
| 32874970 | Unfortunately, till today there is no specific treatment or vaccination for SARS-CoV-2. […] Most of the suggested treatment medications are based on in vitro laboratory investigations, experimental animal models, or previous clinical experience in treating similar viruses such as SARS-CoV-1 or other retroviral infections. | 2020-09-03 |
| 32874973 | It is important to acknowledge the considerable pressure placed on frontline medical staff in the face of a new type of coronavirus that is highly infectious and for which no specific treatment is available. […] Consequently, they will be able to cope better with outbreaks of infectious diseases in the future, to reduce the psychological pressure of the front-line medical staff, and to improve the treatment level. | 2020-09-03 |
| 32874993 | Underlying conditions, especially chronic respiratory diseases, may affect progression, treatment and prognosis of COVID-19. […] This case indicates the dynamic clinical characteristics, laboratory and computed tomography findings and adjustment of treatment, and the possible relationship between glucocorticoid therapy and coronavirus clearance. | 2020-09-03 |
| 32875045 | Here, the authors question the implementation of hydroxy-chloroquine treatment in the context of the COVID-19 pandemic. | 2020-09-03 |
| 32875166 | The high mortality rate from the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections in humans and the lack of effective therapeutic regime for its treatment necessitates the identification of new antivirals. | 2020-09-03 |
| 32875175 | However, if testing capacity is limited to 9,000,000 tests per day (current situation as of 19th August 2020) under continued social-distancing measures, documented cases would plummet significantly, still requiring 5x, 31x and 16x times the current allocated resources (beds for mild cases, ICU beds and mechanical ventilators respectively) to meet unmet need for COVID-19 treatment in India. | 2020-09-03 |
| 32875276 | The role of antifibrotic drug therapy in patients with ongoing SARS-CoV-2 infection or in patients cured of residual pulmonary fibrosis is still to be defined and unclear; the scientific rationale for initiating, continuing, or discontinuing therapy is poorly defined. […] In this article, we describe the advantages of antifibrotic therapy in patients with ongoing SARS-CoV-2 viral infection to prevent the worsening and aggravation of the clinical situation, and the advantages it could have in the role of preventing pulmonary fibrosis after SARS-CoV-2 infection, and in accelerating the complete healing process. | 2020-09-03 |
| 32875281 | Differentiated models of service delivery (DSD models) for HIV treatment in sub-Saharan Africa were conceived as a way to manage rapidly expanding populations of experienced patients who are clinically “stable” on antiretroviral therapy (ART). […] Entry requirements for most models include at least six months on treatment and a suppressed viral load. […] The highest rates of treatment discontinuation are in the first six-month period after treatment initiation. […] Improvements in the treatment initiation process, such as same-day initiation, have not been followed by innovations in the early treatment period. | 2020-09-03 |
| 32875426 | Until now, there is no current vaccine or treatment against SARS-CoV-2. | 2020-09-03 |
| 32875557 | This dataset included insurance claim data before and during COVID-19 treatment and clinical outcomes. | 2020-09-03 |
| 32875601 | Based on the growing body of evidence that cytokine release syndrome, and especially interleukin-6, plays a key role in critically ill Covid-19 patients, we decided to implement therapeutic plasma exchange as a rescue therapy. […] The patient’s clinical status rapidly improved, and biological records showed convincing results of decrease in interleukin-6 and inflammatory parameters under treatment. […] Hence, we think that a further evaluation of risk-benefit balance of this therapy in severe cases of Covid-19 should rapidly be undertaken. | 2020-09-03 |
| 32875716 | Fifteen cases needed intensive care treatment and 16 died. | 2020-09-03 |
| 32875961 | We also project the epidemic curve considering realistic quarantine, social distancing and possible medication scenarios. […] We note that social distancing measures and medication will help flatten the curve; however, without the reintroduction of further lock down, it would be very difficult to make R 0 < 1 . | 2020-09-03 |
| 32875990 | The present review describes the properties of some vegetal products and their derivatives, such as Lupin sp., garlic, salvia and extra virgin olive oil (EVOO) that can be exploit-ed for their beneficial effects, as preventive and/or nutritional treatment of coronavirus disease SARS-CoV2. | 2020-09-03 |
| 32876096 | In addition, there was a greater report of rare complications and greater resistance to the recommended treatment for KD. | 2020-09-03 |
| 32876206 | Outbreak si mulations for the COVID-19 pandemic are performed, using stochastic equations under the following assumptions: a pre-quarantine population R0 of 2.7 or 3.5, a post-quarantine R0 of 1.5, 2 or 2.7, 18% or 40%, of asymptomatic positives and a maximum response capacity of 50 or 150 patients in the intensive care units. | 2020-09-03 |
| 32876222 | There is a marked inflammatory response, up to the cytokine storm, in which anti-inflammatory treatment with pulse therapy with methylprednisolone would be indicated. | 2020-09-03 |
| 32876224 | The latest review (March 27, 2020) showed that there is no evidence to recommend any medication for patients´ treatment with COVID-19. | 2020-09-03 |
| 32876225 | In efforts to reduce the spread of the disease, attention should be paid to the diagnosis and treatment of mental health issues. | 2020-09-03 |
| 32876229 | Carrying out these studies is not only scientifically appropriate, but an ethical and moral obligation to guarantee our patients effective treatment. […] SOLIDARITY is a mega clinical trial that recruited thousands of subjects with moderate to severe disease, who were randomly assigned to one of the treatment groups under evaluation, including hydroxychloroquine, lopinavir/ritonavir associated or not with interferon; or remdesivir compared to standard therapy. | 2020-09-03 |
| 32876241 | National governments and scientific field agents have been looking for evidence for the best practices of prevention and control of transmission, and care of infection and disease, including diagnosis, treatment, and health care measures. | 2020-09-03 |
| 32876249 | When Covid-19 emerged in December last year, there was no vaccine nor was there specific effective treatment for this fast-spreading and life-threatening viral respiratory infection. […] Notwithsanding the absence of evidence of clinical efficacy, these drugs are widely used outside of clinical trials (off label) for prophylaxis and treatment of this viral infection. | 2020-09-03 |
| 32876256 | Most of the included studies were conducted in China with an observational design for the treatment of COVID-19. | 2020-09-03 |
| 32876299 | As a life-threatening event, it requires prompt recognition and expeditious treatment. | 2020-09-03 |
| 32876623 | To date, Remdesivir has been the only antiviral authorized by FDA as therapy for emergency use. […] One of the potential complications of this infection is cytokine storm, which optimal treatment remains unknown. […] Our case illustrates the role of Remdesivir for the treatment of severe COVID-19 pneumonia. | 2020-09-03 |
| 32876633 | It was officially acknowledged in Peru on March 6th, 2020, and has spread rapidly throughout the country, causing first the crisis and then the collapse of the healthcare system, especially emergency care, admissions, and overcrowded intensive care units, not having a specific treatment or the foreseeable possibility of a short-term vaccine. | 2020-09-03 |
| 32876689 | To determine the effect of hydrocortisone on treatment failure on day 21 in critically ill patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and acute respiratory failure. […] The primary outcome, treatment failure on day 21, was defined as death or persistent dependency on mechanical ventilation or high-flow oxygen therapy. […] One hundred forty-eight patients (99.3%) completed the study, and there were 69 treatment failure events, including 11 deaths in the hydrocortisone group and 20 deaths in the placebo group. […] The primary outcome, treatment failure on day 21, occurred in 32 of 76 patients (42.1%) in the hydrocortisone group compared with 37 of 73 (50.7%) in the placebo group (difference of proportions, -8.6% [95.48% CI, -24.9% to 7.7%]; P = .29). […] No serious adverse events were related to the study treatment. […] In this study of critically ill patients with COVID-19 and acute respiratory failure, low-dose hydrocortisone, compared with placebo, did not significantly reduce treatment failure (defined as death or persistent respiratory support) at day 21. | 2020-09-03 |
| 32876695 | Multicenter, randomized, open-label, clinical trial conducted in 41 intensive care units (ICUs) in Brazil. | 2020-09-03 |
| 32876697 | Among patients with severe COVID-19, treatment with a 7-day fixed-dose course of hydrocortisone or shock-dependent dosing of hydrocortisone, compared with no hydrocortisone, resulted in 93% and 80% probabilities of superiority with regard to the odds of improvement in organ support-free days within 21 days. […] However, the trial was stopped early and no treatment strategy met prespecified criteria for statistical superiority, precluding definitive conclusions. | 2020-09-03 |
| 32876719 | The rehabilitation process following cochlear implant (CI) surgery is carried out in a multimodal therapy according to German national guidelines and includes technical and medical aftercare. […] Demographics were analyzed and the quality of medical aftercare, speech therapy, technical aftercare, psychological support and the hygiene modalities were compared to previous rehabilitation stays. […] The quality of rehabilitation and individual therapy were rated as qualitatively similar or improved. | 2020-09-03 |
| 32876786 | • Hydroxychloroquine shortage has become rampart across Africa as the drug is being used as prophylaxis against COVID-19 and this may necessitate a review of treatment plan for some patients with RMDs. | 2020-09-03 |
| 32876925 | The decrease of Covid19 emergency plans contributed to unexpected outcomes (reduction of early stage cancer treatment, decreased operative times and hospital stays, increased VCP rate). | 2020-09-03 |
| 32877233 | The methodologies developed in this effort are likely to find utility in the design of chronic disease therapeutics. | 2020-09-03 |
| 32877352 | In the absence of a vaccine or effective treatment for COVID-19, countries have adopted nonpharmaceutical interventions (NPIs) such as social distancing and full lockdown. | 2020-09-03 |
| 32877380 | For the persistence of chest pain, despite the analgesic therapy, we decided to treat her with a TEVAR. | 2020-09-03 |
| 32877391 | Treatment with angiotensin-converting enzyme inhibitors and receptor blockers is controversial, and there is no evidence not to use these medications in patients with COVID-19. […] Regarding treatment with hydroxychloroquine associated or not with azithromycin, there is evidence of a higher risk with its use than clinical benefit and decreased mortality. | 2020-09-03 |
| 32877490 | The Covid-19 pandemic brought several challenges to the healthcare system: diagnosis, treatment and measures to prevent the spread of the disease. | 2020-09-03 |
| 32877493 | Patients cannot suspend treatment, and they often have comorbidities, which assigns them a higher risk and worse prognosis. | 2020-09-03 |
| 32877494 | We aim to minimize the disease spread, protecting patients and staff, and ensuring the quality of the treatment provided and adequate follow-up for PD patients. | 2020-09-03 |
| 32877496 | We present the recommendations of the Brazilian Society of Nephrology regarding the treatment of pediatric patients with kidney diseases during the COVID-19 pandemic. | 2020-09-03 |
| 32877497 | In stable cases under appropriate treatment, we must choose to contact our patients remotely, using teleconsultations and home exam collections (if possible). […] Dosage suspension or change is not recommended, even in cases in which the patient needs to go to a center to receive his medication; in this case, the infusion center must follow the recommendations of the Ministry of Health. | 2020-09-03 |
| 32877498 | Vascular accesses for hemodialysis are considered the patient’s lifeline and their maintenance is essential for treatment continuity. | 2020-09-03 |
| 32877499 | Palliative care is an approach aimed at relieving suffering, controlling symptoms and seeking to improve quality of life. […] It must be offered in conjunction with standard treatment for any disease that threatens the continuation of life, such as a Covid-19 infection. […] The bioethical principles and strategies used by palliative medicine can assist nephrologists in the care of patients with renal dysfunction, who face the difficulties of isolation at the beginning and follow-up of dialysis in outpatient treatment, and those who are at risk for a more serious disease progress. […] The principles of palliative care are essential to face the challenges of a planet-wide crisis, which raises human suffering in all dimensions, and which requires the construction of strategies that can keep patients assisted, comfortable and with measures proportional to their clinical condition and preferences. | 2020-09-03 |
| 32877500 | The SBN Hypertension Department recommends individualizing treatment and maintaining these medications until better scientific evidence is available. | 2020-09-03 |
| 32877507 | Most patients preferred to resume treatment given the chance regardless of background characteristics; higher self-mastery and greater perceived social support were associated with lower distress, while feeling helpless was associated with higher distress. […] Infertility diagnosis and treatment frequently result in significant psychological distress. […] This cross-sectional questionnaire study included patients whose fertility treatment was suspended following the COVID-19 pandemic, in a tertiary hospital. […] Study variables in the regression model explained 38.9% of the variance in psychological distress experienced by patients during treatment suspension. […] Despite the ministry of health’s decision, 72% of patients wished to resume treatment at the time of survey. […] Furthermore, as the pandemic is stabilising, resumption of treatment should be considered as soon as appropriate according to local conditions. | 2020-09-03 |
| 32877642 | However, our lack of understanding of the molecular processes and host cell signaling events underlying SARS-CoV-2 infection hinders therapy development. […] It provides novel strategies for COVID-19 treatment. | 2020-09-03 |
| 32877828 | Convalescent plasma therapy is already practiced in many countries to help save the lives of severely ill patients. | 2020-09-03 |
| 32877948 | The current pandemic has put forward a challenge to find treatment options. | 2020-09-03 |
| 32878333 | The substantially altered GI anatomy/physiology after bariatric surgery presents new challenges to the field of oral drug therapy. […] Realizing the potentially altered pharmacokinetics of various drugs after bariatric surgery is essential for providing optimal pharmacological therapy and overall patient care. | 2020-09-04 |
| 32878542 | People living with a mental illness are very concerned about disruption of services, running out of medication, and social isolation during this pandemic. | 2020-09-04 |
| 32878574 | After the onset of the pandemic, selected cases of appendicitis were managed with antibiotics which is a recognised treatment option. […] Data were collected retrospectively from electronic records including demographics, investigations, treatment, duration of inpatient stay, complications, readmissions and compared between pre- and post-COVID-19 groups. […] One hundred percent underwent surgical treatment before the onset of pandemic, compared with 56.3% from the onset of the pandemic. | 2020-09-04 |
| 32878619 | The COVID-19 pandemic has placed an unprecedented strain on health systems, with rapidly increasing demand for healthcare in hospitals and intensive care units (ICUs) worldwide. | 2020-09-04 |
| 32878641 | Extensive research has been conducted to understand the molecular basis of the SARS-CoV-2 infection and evolution, develop effective therapeutics, antiviral drugs, and vaccines, and to design rapid and confirmatory viral diagnostics as well as adopt appropriate prevention and control strategies. | 2020-09-04 |
| 32878654 | Demographics, underlying diseases, therapy strategies and test results were collected and analysed from patients on admission, admission to the ICU and 48 h before death. | 2020-09-04 |
| 32878726 | The approach of “delayed conservative treatment” works best in the present case scenario. | 2020-09-04 |
| 32878732 | This study was designed to investigate health-related aspects of individuals with CF, with and without lung transplantation (LTX), their communication with their specialist healthcare providers during the pandemic, potential changes in peoples’ individual therapy regimes and daily physical activity levels. […] However, strict lockdown measures substantially affected peoples’ physical activity levels, a vital cornerstone of CF therapy; and this is worrisome. | 2020-09-04 |
| 32878736 | Voice therapy faces a double challenge, interventions using telepractice, and delivering rehabilitation services to a growing population of patients at risk of functional impairment related to the COVID-19 disease. […] Moreover, as COVID-19 is transmitted through droplets, it is critical to understand how to mitigate these risks during assessment and treatment. […] The clinical guide provides 65 recommendations for clinicians in the management of voice disorders during the pandemic and includes advice from assessment, direct treatment, telepractice, and teamwork. | 2020-09-04 |
| 32878841 | Treatment included hydration, forced diuresis and continuous renal replacement therapy. | 2020-09-04 |
| 32878898 | In the patient cohort, most individuals are on active anticancer treatment (96.4%). 26% of the HCP and 6% of the patients had symptoms potentially associated with COVID-19 since the end of February 2020. | 2020-09-04 |
| 32878932 | Conventional assays that monitor SARS-CoV-2 growth in cell culture rely on costly and time-consuming RNA extraction procedures, hampering progress in basic SARS-CoV-2 research and development of effective therapeutics. […] This simplified assay will undoubtedly expedite basic SARS-CoV-2 and virology research and be amenable to use in drug screening platforms to identify therapeutics against SARS-CoV-2. | 2020-09-04 |
| 32879082 | The general data, epidemiological data, laboratory tests, imaging examinations, and treatment of 71 patients with COVID-19 admitted to the Sixth People’s Hospital of Zhengzhou from January 19, 2020 to March 3, 2020 were retrospectively analyzed. | 2020-09-04 |
| 32879098 | By analyzing patients’ demands, outpatient service system and emergency system complemented each other with the help of “internet medical” to provide online medical treatment, self-diagnosed pneumonia program, online pharmacies, outpatient appointment and online pre-examination services, open green channels for special patients, and to provide referral services for critical patients. | 2020-09-04 |
| 32879101 | To explore the significance of coagulation and immune function indicators in clinical diagnosis and treatment of coronavirus disease 2019 (COVID-19). […] There are some abnormalities in coagulation and immune function in patients with COVID-19, which possess significance for clinical diagnosis and treatment of the disease. | 2020-09-04 |
| 32879102 | Before treatment, the fasting plasma glucose (FPG) levels were significantly higher in the critically ill patient’s group [(10.23±3.71) mmol/L] compared to those in the severely ill patients [(7.12±3.35) mmol/L, P<0.05]. […] In our study, 15 (34.8%) of the severely ill and 10 (83.3%) critically ill patients received the steroid treatment. | 2020-09-04 |
| 32879103 | This article is to analyze the predictive role of clinical features in patients with COVID-19 for severe disease, so as to help doctor monitor the severity-related features, restrain the disease progress, and provide a reference for improvement of medical treatment. […] The clinical data of 208 patients with COVID-19 who were isolated and treated in Changsha Public Health Treatment Center from January 17, 2020 to March 14, 2020 were collected. […] According to the “Program for the diagnosis and treatment of novel coronavirus (COVID-19) infected pneumonia (Trial version 7)” issued by the General Office of National Health Committee and Office of State Administration of Traditional Chinese Medicine as the diagnostic and typing criteria. | 2020-09-04 |
| 32879104 | Retrospective analysis was performed on the clinical data of all elderly COVID- 19 patients treated in Changsha Public Health Treatment Center from January 17, 2020 to March 15, 2020, which included basic diseases, symptoms, test results, and other clinical characteristics, and prognostic indicators such as severity of illness, length of hospital stay, virus shedding time and mortality rate. | 2020-09-04 |
| 32879105 | Therefore, this review combines the existing research results with clinic experience of diagnosis and treatment for senile infectious diseases, summarizes the clinical characteristics and puts forward the prevention strategies of elderly COVID-19 patients, which provide evidence for effective prevention and treatment of COVID-19 in elderly patients, improvement of cure rate, and reduction of severe incidence rate and mortality. | 2020-09-04 |
| 32879109 | To explore the prescribing habits of doctors, and to provide basis for rational use of antibiotics in clinical practice via investigating and analyzing the applications of antibiotics in treatment of coronavirus disease 2019 (COVID-19) in the designated hospital. […] Broad-spectrum, high-potency antibiotics are used at the beginning of COVID-19 treatment. […] The varieties of antibiotics meet the requirements of the management of antibiotics, and the utilization rate of antibiotics and the cost proportion of antibiotics in COVID-19 patients are within a reasonable range.In the future, for the treatment of COVID-19, we should continue to summarize the experience, improve the strategies, and rationally apply antibiotics on the basis of guidelines. | 2020-09-04 |
| 32879113 | Very little about SARS-CoV-2 is known and there is no precedent for treatment. […] The National Health Commission has repeatedly revised the diagnosis and treatment guide for the coronavirus disease 2019. […] The latest guide is “New Coronary Virus-Infected Pneumonia Diagnosis and Treatment Plan (Seventh Trial Version)”(short for Seventh Version of Diagnosis and Treatment Plan). […] But the later 2 drugs aren’t mentioned in the Seventh Version of Diagnosis and Treatment Plan. | 2020-09-04 |
| 32879114 | As hospitals at all levels will gradually resume their routine medical work, effective managements for the airway of the silent asymptomatic carriers and patients with delayed symptoms, treatment for severe patients, and prevention of cross infection in hospital have become the focus for the current prevention and control of nosocomial infections. | 2020-09-04 |
| 32879115 | It is difficult for medical workers to provide a better perioperative treatment for surgery patient with COVID-19 while avoiding hospital spread effectively. | 2020-09-04 |
| 32879154 | However, in cycle 4 of M-CHOP therapy, she developed fever with mild cough. […] Considering severe immunosuppression caused by ATL, we initiated favipiravir therapy. […] SARS-CoV-2 PCR tests were negative on days 17 and 18 of favipiravir therapy, and the patient was discharged without residual disease on the final CT. […] Further accumulation of data regarding COVID-19 in patients with hematological malignancies is warranted to clarify the risk factors for severe illness, the best-in-class antiviral agent, and the optimal treatment strategy in this population. | 2020-09-04 |
| 32879590 | Esophageal cancer, in particular, is one of the deadliest types of malignancy worldwide, reflecting both aggressive biology and a lack of adequate treatment. […] The primary aim of this review is to summarize the salient evidence for recommendations and optimal treatment strategies for patients with esophageal cancer amidst the COVID-19 pandemic. | 2020-09-04 |
| 32879592 | As prospective studies begin to emerge, clinicians will have more robust research data to diagnose COVID-19 patients earlier and identify patients in need of more intensive treatment. | 2020-09-04 |
| 32879801 | In light of the references published, this review demonstrates the biological features, spread, diagnosis and treatment of SARS-CoV-2 as a whole and aims to analyse the similarities and differences among SARS-CoV-2, SARS-CoV and MERS-CoV to provide new ideas and suggestions for prevention, diagnosis and clinical treatment. | 2020-09-04 |
| 32879841 | There is an urgent need to share experiences and offer guidance on decision-making with regard to the indications and standards for radiation therapy in the treatment of lung cancer. […] In the present article, the Oncological Group for the Study of Lung Cancer of the Spanish Society of Radiation Oncology reviews the literature and establishes a series of consensus-based recommendations for the treatment of patients with lung cancer in different clinical scenarios during the present pandemic. | 2020-09-04 |
| 32880032 | Its use has been explored as an adjunctive therapy in refractory thrombosis in antiphospholipid syndrome. […] Hydroxychloroquine, methotrexate and colchicine are also being tried at different stages of the ongoing Coronavirus Disease 19 (COVID-19) pandemic for prophylaxis and treatment. | 2020-09-04 |
| 32880078 | Although no proven therapies are identified yet which can offer a definitive treatment of the COVID-19, a series of antiviral, antibacterial, antiparasitic, immunosuppressant drugs have shown clinical benefits based on repurposing theory. […] As society is running against the time to combat the COVID-19, we present here a comprehensive review dealing with up-to-date information of therapeutics or drug regimens being utilized by physicians to treat COVID-19 patients along with in-depth discussion of mechanism of action of these drugs and their targets. […] Ongoing vaccine trials, monoclonal antibodies therapy and convalescent plasma treatment are also discussed. | 2020-09-04 |
| 32880102 | A total of 475 patients with non-severe COVID-19 pneumonia were enrolled, 55 patients received early, low-dose, and short-term corticosteroids therapy, 420 patients received non-corticosteroids therapy. […] The percentages of antibiotics therapy (89.1% vs 23.6%, p < 0.001), use of at least two antibiotics (38.2% vs 12.7%, p = 0.002), and antifungal therapy (7.3% vs 0, p = 0.042) were higher in the corticosteroids group than those in the non-corticosteroids group. […] In adult patients with non-severe COVID-19 pneumonia, early, low-dose, and short-term corticosteroids therapy was associated with worse clinical outcomes. | 2020-09-04 |
| 32880303 | Convalescent plasma is being considered as a potential therapy for COVID-19. […] We highlight and contextualise the findings of a recent Cochrane rapid review that evaluated the effectiveness and safety of convalescent plasma or hyperimmune immunoglobulin transfusion in the treatment of people with COVID-19. […] Further investigation of the clinical benefits of the therapy in well-designed studies is needed to provide more evidence that will guide COVID-19 treatment decision-making in the SA context. | 2020-09-04 |
| 32880337 | Given that severely ill patients admitted to intensive care units are at high risk of mortality, establishing the cause of death at a histopathological level could prove invaluable in contributing to the understanding of COVID-19. | 2020-09-04 |
| 32880390 | Systemic corticosteroids are now recommended in many treatment guidelines, although supporting evidence is limited to 1 randomized controlled clinical trial (RECOVERY). […] Multivariable Cox models, Cox model with time-varying exposure and propensity score analysis (inverse-probability-of-treatment-weighting [IPTW] and propensity score matching [PSM]) were used to estimate the association of corticosteroid use with risk of in-hospital mortality in severe and critical cases. […] Absence of the beneficial effect in our study in contrast to that observed in the RECOVERY clinical trial may be due to biases in observational data, in particular prescription by indication bias, differences in clinical characteristics of patients, choice of corticosteroid used, timing of initiation of treatment, and duration of treatment. | 2020-09-04 |
| 32880453 | As corona virus disease 2019 (COVID-19) is a rapidly growing public health crisis across the world, our knowledge of meaningful diagnostic tests and treatment for severe acute respiratory syndrome coronavirus 2 (SARS-COV-2) is still evolving. | 2020-09-04 |
| 32880651 | Vitamin D treatment has been found to decrease the incidence of viral respiratory tract infection, especially in patients with vitamin D deficiency. […] Treatment changes were defined by changes in vitamin D type and dose between the date of the last vitamin D level measurement and the date of COVID-19 testing. […] Vitamin D deficiency and treatment changes were combined to categorize the most recent vitamin D status before COVID-19 testing as likely deficient (last level deficient and treatment not increased), likely sufficient (last level not deficient and treatment not decreased), and 2 groups with uncertain deficiency (last level deficient and treatment increased, and last level not deficient and treatment decreased). | 2020-09-04 |
| 32880957 | Variation among strains may lead to the rapid evolution of resistance to therapeutics. | 2020-09-04 |
| 32881007 | This review was conducted to evaluate the impact of glucocorticoid therapy in patients with COVID-19 based on the publications reported to date. […] Systemic steroid therapy may not be effective for reducing mortality, duration of hospitalization, and period of viral shedding. | 2020-09-04 |
| 32881059 | A novel concept in DNA vaccine design is the creation of an inhaled DNA plasmid construct containing a portion of the coronavirus spike protein for treatment and vaccination. […] The secreted protein binding to the ACE2 receptor provides a unique mechanism of action for treatment to all strains of coronavirus in naïve patients, by blocking the ACE2 receptor site. | 2020-09-04 |
| 32881062 | At present,there is yet no specific antiviral treatment or immunization against the newly identifiedhuman severe acute respiratory syndrome virus (SARS-CoV2) that results in a rapidly progressive pandemic coronavirus disease 2019 (COVID-19). […] We hypothesise nicorandil would be an effective form of adjuvant therapy against COVID-19. | 2020-09-04 |
| 32881072 | Erythema was considered to be caused by COVID-19 and not a drug-induced eruption because, in all cases, erythema was relieved merely by external medicine and oral antihistamines, without discontinuing the original medication. | 2020-09-04 |
| 32881116 | Leveraging technology to provide evidence-based therapy for posttraumatic stress disorder (PTSD), such as prolonged exposure (PE), during the COVID-19 pandemic helps ensure continued access to first-line PTSD treatment. […] Further, some of the limitations associated with the pandemic, including stay-at-home orders and physical distancing, require that providers become adept at applying principles of exposure therapy with more flexibility and creativity, such as when assigning in vivo exposures. | 2020-09-04 |
| 32881266 | Treatment efficacy trials are needed to clarify the utility of unproven treatments. | 2020-09-04 |
| 32881285 | WPB size responds to physiological cues and pharmacological treatment, and VWF secretion from shortened WPBs dramatically reduces platelet and plasma VWF adhesion to an endothelial surface. […] We hypothesized that WPB-shortening represented a novel target for antithrombotic therapy. […] This set of compounds acting at a very early stage of the hemostatic process could well prove to be a useful adjunct to current antithrombotic therapeutics. | 2020-09-04 |
| 32881340 | We performed a retrospective analysis to compare and evaluate the effect of low molecular weight heparin (LMWH) treatment on disease progression. […] Changes in the percentage of lymphocytes before and after LMWH treatment were significantly different from those in the control group (P = 0.011). […] Likewise, changes in the levels of D-dimer and fibrinogen degradation products in the LMWH group before and after treatment were significantly different from those in the control group (P = 0.035). […] Remarkably, IL-6 levels were significantly reduced after LMWH treatment (P = 0.006), indicating that, besides other beneficial properties, LMWH may exert an anti-inflammatory effect and attenuate in part the “cytokine storm” induced by the virus. […] Our results support the use of LMWH as a potential therapeutic drug for the treatment of COVID-19, paving the way for a subsequent well-controlled clinical study. | 2020-09-04 |
| 32881350 | Oxygen therapy has been ceased in three patients. […] Four adverse events potentially associated with tocilizumab therapy occurred in three patients: ventilator-associated pneumonia, bacteremia associated with central venous catheterization, myositis and hepatitis. […] We recommend tocilizumab be included in randomized controlled trials of treatment for patients with severe COVID-19 pneumonia, and be considered for compassionate use in such patients pending the results of these trials. | 2020-09-04 |
| 32881359 | This open-label randomized controlled pilot study aimed to test the study feasibility of bromhexine hydrochloride (BRH) tablets for the treatment of mild or moderate coronavirus disease 2019 (COVID-19) and to explore its clinical efficacy and safety. […] Routine treatment according to China’s Novel Coronavirus Pneumonia Diagnosis and Treatment Plan was performed in both groups, whereas patients in the BRH group were additionally given oral BRH (32 mg t.i.d.) for 14 consecutive days. […] There were suggestions of BRH advantage over placebo in improved chest computed tomography, need for oxygen therapy, and discharge rate within 20 days. | 2020-09-04 |
| 32881412 | The overarching principle is to deliver best, evidence-based treatment without compromising patient care while ensuring the safety of healthcare workers. | 2020-09-04 |
| 32881593 | CQ and HCQ are typically used for the treatment of malaria but have been recognized for certain beneficial effects in COVID-19 patients based on some clinical outcomes from the clinical treatment of COVID-19. | 2020-09-04 |
| 32881641 | Administration of convalescent plasma as a possible therapy was used in the case of viral pneumonia including SARS and influenza. | 2020-09-04 |
| 32881656 | The significant prognostic adverse effect of SARS-CoV-2 on PD and the present-day treatment options, clinical presentation and various mechanism is warrant need of the hour. | 2020-09-04 |
| 32881659 | Treatment is symptomatic. | 2020-09-04 |
| 32881685 | The cardiopulmonary information was delivered to the frontline clinicians immediately for further treatment. | 2020-09-04 |
| 32881845 | Hydroxychloroquine and chloroquine, primarily used to treat autoimmune diseases and to prevent and treat malaria, received national attention in early March 2020, as potential treatment and prophylaxis for coronavirus disease 2019 (COVID-19) (1). […] § Following the FDA’s issuance of caution and EUA rescindment, on May 12 and June 16, the federal COVID-19 Treatment Guidelines Panel issued recommendations against the use of hydroxychloroquine or chloroquine to treat COVID-19; the panel also noted that at that time no medication could be recommended for COVID-19 pre- or postexposure prophylaxis outside the setting of a clinical trial (3). […] Although dispensing trends are returning to prepandemic levels, continued adherence to current clinical guidelines for the indicated use of these medications will ensure their availability and benefit to patients for whom their use is indicated (3,4), because current data on treatment and pre- or postexposure prophylaxis for COVID-19 indicate that the potential benefits of these drugs do not appear to outweigh their risks. | 2020-09-04 |
| 32881895 | Nicholas White and coauthors discuss chloroquine and hydroxychloroquine pharmacology in the context of possible treatment of SARS-CoV-2 infection. | 2020-09-04 |
| 32881982 | As primary outcomes, we studied the evolution of SAFI ratio (oxygen saturation/fraction of inspired oxygen) in the first 48 hours of treatment and the time to discharge. […] In the analysis of these matched subcohorts, SAFI at 48h had no significant changes associated to the use of azithromycin, though azithromycin treatment was associated with a longer time to discharge (10.0 days vs 6.7 days; log rank: p = 0.039). […] We did not find a clinical benefit associated with the use of azithromycin, in terms of lung function 48 hours after treatment or length of hospital stay. | 2020-09-04 |
| 32882066 | Palliative care (PC) represents an approach that encompasses the procedures to relieve pain and distressing symptoms and maintain function as much as possible in the terminally ill patient until death. […] The care is provided at different time points of diseases (i.e., from in-therapy care to survivorship care to end-of-life care). | 2020-09-04 |
| 32882074 | Detection, diagnosis, and treatment of hypertension require accurate blood pressure assessment. | 2020-09-04 |
| 32882079 | This narrative review aims to discuss the management of pemphigus in the era of COVID-19, considering the necessity to balance suitable pemphigus treatment with minimal risk of COVID-19-related mortality and morbidity. […] Postponing rituximab treatment should be considered on a case by case basis. | 2020-09-04 |
| 32882193 | While medical management remains a reasonable option in carefully selected patients at prohibitive risk for open surgery, endovascular therapies for treatment of ATAAD are rapidly evolving. […] Early surgical repair remains the preferred treatment for most patients with ATAAD, however, improvements in risk stratification should guide appropriate delay or permanent deferral of surgery in select individuals. | 2020-09-04 |
| 32882216 | The lack of vaccine and effective therapeutic agents for the disease prompted world-wide effort to test those antiviral therapeutics already in use for other diseases. | 2020-09-04 |
| 32882350 | In our study, we have highlighted the unique treatment required for these patients and discussed the role of anticoagulation for patients diagnosed with COVID-19. […] More data are urgently needed to optimize treatment and prevent further vascular complications of COVID-19 infections. | 2020-09-04 |
| 32882358 | Although the importance of palliative care (PC) integration in the emergency department (ED) has long been recognized, few formalized programs have been reported, and none have evaluated the experience of ED clinicians with embedded PC. | 2020-09-04 |
| 32882361 | Plants that locals have been using for centuries for the prevention and treatment of influenza can offer effective alternatives to combat this problem. […] This study has been carried out to reveal the inventory of plant species that have been used in flu treatment for centuries in Turkish folk medicine, which could be used in the treatment of flu or flu-like pandemics, such as COVID 19, that humanity has been suffering with, and also compare them with experimental studies in the literature. […] This is the first nationwide ethnomedical screening work conducted on flu treatment with plants in Turkey. […] Phlocosa (an endemic taxon), that were found to be used in the treatment of both flu and malaria. | 2020-09-04 |
| 32882501 | Cladribine is a highly effective, recently available treatment in multiple sclerosis. […] This case report describes a patient with COVID-19 infection during second year treatment with cladribine. | 2020-09-04 |
| 32882643 | Statin is one of the drugs which is most commonly used for the treatment of dyslipidemic patients. | 2020-09-04 |
| 32882706 | The concept of COVID-19 as an endothelial disease provides a unifying pathophysiological picture of this raging infection, and also provides a framework for a rational treatment strategy at a time when we possess an indeed modest evidence base to guide our therapeutic attempts to confront this novel pandemic. | 2020-09-04 |
| 32882719 | Similar results were obtained when specifically analyzing studies on patients admitted to intensive care units and those on patients under antithrombotic prophylaxis. | 2020-09-04 |
| 32882720 | Therefore, low- to moderate-intensity exercise could be an adjuvant therapy for people with mild-to-moderate COVID-19 and reduce the risk of developing severe symptoms of illness that are associated with enhanced mortality. | 2020-09-04 |
| 32882738 | A higher percentage of dentists from the least affected states continued routine dental treatment; dentists were younger and presented a significantly lower level of concern about dental treatments and oral health conditions of their patients. | 2020-09-04 |
| 32882767 | The outcomes of patients who did (cases) or did not (controls) receive darunavir-cobicistat (800-150 mg) therapy were compared. […] Fourteen patients received darunavir-cobicistat treatment, and 96 received other antiviral therapy (controls). […] In conclusion, darunavir-cobicistat therapy was found to be associated with a significant survival benefit in critically ill patients with SARS-CoV-2 infection. | 2020-09-04 |
| 32882888 | We show results of the first clinical trials on chloroquine (CQ) and hydroxychloroquine (HCQ) in the treatment of COVID-19, as well as earlier reports on the anticoronaviral properties of these two compounds and of Zn(II) itself. […] Other FDA-approved Zn(II) ionophores are given a decent amount of attention and are thought of as possible COVID-19 therapeutics. | 2020-09-05 |
| 32883050 | Until vaccines and effective therapeutics become available, the practical solution to transit safely out of the current coronavirus disease 19 (CoVID-19) lockdown may include the implementation of an effective testing, tracing and tracking system. | 2020-09-05 |
| 32883081 | We also analyzed the possible role of medication and risk factors (such as smoking) in the disease’s evolution and clinical course. | 2020-09-05 |
| 32883106 | Although the use of fibrinolytic therapy has progressively decreased over the last several decades in high-income countries, in circumstances when delays in timely delivery of primary percutaneous coronary intervention are expected, a modern fibrinolytic-based pharmacoinvasive strategy may need to be considered. | 2020-09-05 |
| 32883328 | Data are suggestive of tocilizumab as a potential treatment for patients with COVID-19 infection. […] The trial statistician will be blinded for data analysis and will be kept unaware of treatment group assignments. | 2020-09-05 |
| 32883368 | Currently, there are neither specific antiviral drugs for the treatment or preventive drugs such as vaccines. […] We proposed a bioinformatics analysis to test in silico existing drugs as a fast way to identify an efficient therapy. […] The integration of drug-gene interactions in the network and molecular docking analysis allows us to obtain several drugs with antiviral activity that, alone or in combination with other treatment options, could be considered as therapeutic approaches against COVID-19. | 2020-09-05 |
| 32883382 | In response to the Ebola outbreak of 2014-2016, the US Office of the Assistant Secretary for Preparedness and Response (ASPR) established 10 regional treatment centers, called biocontainment units (BCUs), to prepare and provide care for patients infected with high-consequence pathogens. | 2020-09-05 |
| 32883537 | One-hundred and four patients continued treatment without interruption or delay, while 49 patients had a treatment delay. […] The main reasons for treatment delay were older age (median age of the group of patients with or without treatment-delay, respectively 60 and 69 years, P value <0.001) and/or presence of comorbidities (percentage of patients with at least one comorbidity respectively 81% and 62%, in patients with or without treatment delay, P value = 0.001). | 2020-09-05 |
| 32883593 | The virus is novel, and currently there is no approved treatment. […] Convalescent plasma may offer a treatment option. | 2020-09-05 |
| 32883669 | This study evaluates the impact of the coronavirus disease 2019 pandemic on presentation, treatment, and outcomes of patients with emergent large-vessel occlusion using data from a large health system in the Bronx, New York. […] The pandemic led to delays in patients arriving at hospitals, leading to decreased patients eligible for treatment, while in-hospital evaluation and treatment times remain unchanged. | 2020-09-05 |
| 32883809 | Widespread testing for the presence of the novel coronavirus SARS-CoV-2 in individuals remains vital for controlling the COVID-19 pandemic prior to the advent of an effective treatment. | 2020-09-05 |
| 32884153 | This model should prove useful for preclinical studies of SARS-CoV-2 vaccines, therapeutics and pathogenesis. | 2020-09-05 |
| 32884178 | [Purpose] To summarize the existing official guidelines issued by the World Confederation for Physical Therapy and Associations of Physical Therapy in various countries and to clarify the recommended methods of respiratory rehabilitation and physiotherapy for patients in different stages of the coronavirus disease of 2019 (COVID-19). […] [Methods] An introductory literature search was conducted using the keywords “COVID-19”, “respiratory rehabilitation”, “physical therapy”, and others in the database of the Association of Physical Therapy. […] [Results] Using 12 coronavirus disease-2019 rehabilitation-related articles, we summarized data on physical therapy (PT) evaluation; treatment; indications; contraindications; and termination indicators for patients in acute, stable, and post-discharge stages. | 2020-09-05 |
| 32884243 | The COVID-19 epidemic has caused difficulties in continuous treatment for patients with chronic diseases and resulted in nonadherence to treatment and adverse health outcomes. […] This study aimed to investigate the associations of nonadherence to treatment with patient-reported outcomes of psoriasis during the COVID-2019 epidemic. […] Demographic and clinical data, nonadherence to treatment, and patient-reported outcomes were collected. […] A total of 634 (68.5%) reported nonadherence to treatment, and worse adherence was found among patients receiving systemic treatment (adjusted odds ratio [AOR]: 2.67; 95% CI: 1.40-5.10) and topical treatment (AOR: 4.51; 95% CI: 2.66-7.65) compared to biological treatment. […] Nonadherence to treatment (less than two weeks and more than two weeks) was significantly associated with deterioration of psoriasis (aOR: 2.83 to 5.25), perceived stress (AOR: 1.86 to 1.57), and symptoms of anxiety (AOR: 1.42 to 1.57) and depression (AORs: 1.78). […] Subgroup analysis by treatment showed consistent results in general. […] Nonadherence to treatment was associated with the aggravation of psoriasis conditions, perceived stress, and symptoms of anxiety and depression. | 2020-09-05 |
| 32884251 | Due to legal restrictions of remote treatment in Germany, which were recently loosened, telemedicine is still in the early stages. | 2020-09-05 |
| 32884277 | Here, however, we examined the evidence of NMOSD disease-modifying therapies (DMTs) use during the present period and highlighted different scenarios including treatment of relapses as well as initiation and maintenance of DMTs in order to optimize care of NMOSD patients in the COVID-19 era. | 2020-09-05 |
| 32884379 | However, because of the urgency of the disease and the timeliness of treatment, gynecological tumor patients cannot be administered in the hospital until the pandemic situation could be controlled entirely. […] Consequently, this review proposes the following suggestions and our experience about preventing and controlling of COVID-19 and the treatment for patients with gynecological tumors in gynecology departments. | 2020-09-05 |
| 32884603 | These drugs are commonly used for the treatment of Rheumatoid Arthritis (RA) and Systemic Lupus Erythematosus (SLE) because of its immunomodulatory effects. | 2020-09-05 |
| 32884871 | The authors believe that based on current knowledge, KD treatment delays may carry deleterious effects in the near future for children with COVID-19-related Kawasaki disease. | 2020-09-05 |
| 32884879 | This case illustrates a combination of factors including hypertension, triple therapy (aspirin, clopidogrel, and enoxaparin), and underlying coagulopathy due to COVID-19, which contributed to the life-threatening intracranial hemorrhage in this patient. | 2020-09-05 |
| 32885037 | We recommend consensus guidelines for the clinical treatment of Parkinson’s patients with COVID-19. | 2020-09-05 |
| 32885172 | Demographic, clinical, laboratory, treatment, and outcome data extracted from electronic medical records. […] One-hundred twenty-one of 137 (78.1%) required mechanical ventilation of whom 30 (24.8%) moved to tracheostomy and 46 of 137 (33.6%) required new onset renal replacement therapy. | 2020-09-05 |
| 32885174 | Radiology, intracranial pressure, intracranial compliance (correlation between intracranial pressure amplitude and mean intracranial pressure), cerebral vasomotor reactivity (pressure reactivity index), arterial blood pressure, cerebrospinal fluid chemistry, and treatment. | 2020-09-05 |
| 32885277 | Ocular implications should also be considered for therapy. […] In fact, one potential treatment is chloroquine and its derivatives, including hydroxychloroquine. | 2020-09-05 |
| 32885345 | The results showed that the use of corticosteroids in the treatment of autoimmune diseases can make diagnosis and treatment of COVID-19 more challenging by preventing the fever. […] Due to the common pathogenesis of COVID-19 and autoimmune diseases, the use of autoimmune drugs as a possible treatment option could help control the virus. | 2020-09-05 |
| 32885373 | There is no effective therapy for COVID-19. […] Hydroxychloroquine (HCQ) and chloroquine (CQ) have been used for its treatment but their safety and efficacy remain uncertain. […] We performed a systematic review to synthesize the available data on the efficacy and safety of CQ and HCQ for the treatment of COVID-19. | 2020-09-05 |
| 32885429 | We compared the treatment changes before and after the national emergency was declared. […] Treatment protocols were changed with a 200% increase in short course radiation in rectal cancer. […] Treatment decisions were made based on the state of affairs that COVID-19 had created during that cross-section of time and protocols were redrawn to strike a balance between the risk of death from colorectal cancer and the risk of death from COVID-19 infection. | 2020-09-05 |
| 32885539 | As we gain experience managing COVID-19, more data become available on disease severity, course, and treatment in patients infected with the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). […] Additionally, the inclusion of pregnant patients in therapeutic trials will provide vital data on treatment options for patients. | 2020-09-05 |
| 32885595 | The aim of this study was to investigate the impact of the COVID-19 pandemic on people living with severe obesity (BMI ≥35 kg/m2), currently engaged in multi-modal treatment. […] The primary objectives were to examine the impact of the pandemic on their lived experience from a treatment and psychosocial standpoint and additionally explore their awareness of obesity as a risk factor for COVID-19 disease severity. […] Themes that emerged from the perspective of impact on lived experience were (a) challenge sustaining treatment and (b) psychosocial impact. […] This has implications for their on-going treatment. | 2020-09-05 |
| 32885616 | Therapeutics are based on nanotechnology strategies as well and focus on antiviral drug design and on new nanoarchitectured vaccines. | 2020-09-05 |
| 32885641 | Summing up, the authors indicate that during the pandemic of the new coronavirus infection COVID-19, otorhinolaryngologists need to adhere to two fundamental principles aimed at preventing the spread of infection: the use of modern effective personal protective equipment and the use of examination methods (surgical treatment methods) that prevent the formation of biological aerosols. | 2020-09-05 |
| 32885776 | In the Amazon region of Loreto, where malaria cases are concentrated, COVID-19 has led to near-complete closure of the primary healthcare system, and diagnosis and treatment of acute febrile illnesses, including malaria, has plummeted. | 2020-09-05 |
| 32885815 | Sudden changes in the delivery of pain management interventions will probably alter treatment effects measured via PMC PCTs. | 2020-09-05 |
| 32885971 | As the crucial mediator of infection, the viral glycosylated spike protein (S) has attracted the most attention and is at the center of efforts to develop therapeutics and diagnostics. | 2020-09-05 |
| 32886210 | Surgeons, and other medical workers in the field of surgery, have a solid foundation and experience in medical treatment and intensive care, and an understanding of the support of respiratory, circulatory, digestive, and other systemic organs. […] As surgeons in the anti-pandemic front line in China, we describe our experience with the diagnosis and treatment of COVID-19 in this country and how the work of surgeons is unfolding during the pandemic. | 2020-09-05 |
| 32886428 | Awareness of late TTS and bed-side echocardiographic evaluation can lead to prompt identification and treatment. | 2020-09-05 |
| 32886623 | However, medical workers demonstrated a slightly advanced knowledge in their responses to professional questions such as the potential susceptible population, possible host, treatment of COVID-19, and disease category. | 2020-09-04 |
| 32886671 | In the absence of a readily available medical treatment, any strategy to contain the virus in the US will depend on the behavioral response of US residents. | 2020-09-04 |
| 32886696 | We simulate different possible strategies for the mitigation of the current outbreak, slowing down the spread of the virus and thus reducing the peak in daily diagnosed cases, the demand for hospitalization or intensive care units admissions, and eventually the number of fatalities. | 2020-09-04 |
| 32886711 | This will assist healthcare workers in diagnosing COVID-19 and assessing disease severity, facilitate the selection of appropriate treatment options, which is important for reducing the spread of the virus, saving lives, and controlling the pandemic. | 2020-09-04 |
| 32886750 | Donor registries and transplantation societies recommend cryopreservation of unrelated donor hemopoietic progenitor cell (HPC) products before the recipient commences conditioning therapy to mitigate the donor and travel risks associated with the COVID-19 pandemic. | 2020-09-04 |
| 32886789 | Existing literature can provide guidance to health care leadership teams to appropriately and safely leverage physical therapy resources and skill sets during the COVID-19 pandemic. […] The purpose of this study was to provide a review of the pandemic and physical disaster management literature to summarize physical therapy-specific operational considerations to assist hospital-based leadership teams in planning and response efforts during the COVID-19 pandemic. […] The review team included 3 physical therapist clinician researchers, a health librarian, and a member of the physical therapy leadership team. […] Five main categories of operational considerations for physical therapy during the COVID-19 pandemic were identified: (1) organizational actions, (2) staffing considerations, (3) physical therapist roles, (4) physical resources, and (5) other considerations. […] Evidence-informed facility-based and regional planning during the current COVID-19 pandemic will help physical therapists enhance their role in treating patients in physical therapy and rehabilitation settings. | 2020-09-04 |
| 32886846 | Thorough screening of incoming patients, separation of diagnostic and treatment areas, regional management, hierarchical protection, disinfection protocols, and other measures were enforced to prevent virus transmission during endoscopic treatments. | 2020-09-04 |
| 32886893 | As no effective treatment is known, prediction of disease severity is very important in order to estimate a patients outcome. | 2020-09-04 |
| 32886952 | However, the benefits of convalescent plasma treatment can only be clearly established through carefully designed randomized clinical trials. […] Despite promising pilot studies, large multicenter randomized controlled trials failed to show a benefit of convalescent plasma or hyperimmune intravenous globulin for the treatment of severe influenza A virus infection. […] These studies provide important lessons that should inform the planning of adequately powered randomized controlled trials to evaluate the promise of convalescent plasma therapy in COVID-19 patients. | 2020-09-04 |
| 32887191 | Healthcare professionals should establish comprehensive treatment plans for pregnant women who are highly vulnerable population to prevent mental trauma during the infectious disease outbreaks. | 2020-09-05 |
| 32887260 | We have previously shown that the combination of radiotherapy with human umbilical-cord-derived mesenchymal stromal/stem cells (MSCs) cell therapy significantly reduces the size of the xenotumors in mice, both in the directly irradiated tumor and in the distant nonirradiated tumor or its metastasis. | 2020-09-05 |
| 32887358 | A further concern is the on-going emergence of antimicrobial resistance, which seriously limits treatment. | 2020-09-05 |
| 32887532 | Accordingly, these cell surface enzymes constitute appealing therapeutic targets to develop host-based therapeutics against respiratory viral diseases. […] Expert opinion: Several TTSPs of the respiratory tract represent attractive pharmacological targets in the treatment of respiratory infectious diseases (notably COVID-19 and influenza), but also against idiopathic pulmonary fibrosis and lung cancer. | 2020-09-05 |
| 32887660 | The most common treatment options used were hydroxychloroquine (79.7%), ribavirin (65.2%), and oxygen therapy (78.8%). | 2020-09-05 |
| 32887670 | Diagnosis and treatment guidelines for clinicians caring for patients are needed. […] In the early stage, we have issued “A rapid advice guideline for the diagnosis and treatment of 2019 novel coronavirus (2019-nCoV) infected pneumonia (standard version)”; now there are many direct evidences emerged and may change some of previous recommendations and it is ripe for develop an evidence-based guideline. | 2020-09-05 |
| 32887691 | What is the role of drug interventions in the treatment and prevention of covid-19? […] The panel made a strong recommendation for use of corticosteroids in severe and critical covid-19 because there is a lower risk of death among people treated with systemic corticosteroids (moderate certainty evidence), and they believe that all or almost all fully informed patients with severe and critical covid-19 would choose this treatment. […] In contrast, the panel concluded that patients with non-severe covid-19 would decline this treatment because they would be unlikely to benefit and may be harmed. […] Moreover, taking both a public health and a patient perspective, the panel warned that indiscriminate use of any therapy for covid-19 would potentially rapidly deplete global resources and deprive patients who may benefit from it most as potentially lifesaving therapy. | 2020-09-05 |
| 32887790 | Taken together, the refinement of models of SARS-CoV-2 infection will be critical to guide the development of therapeutics and vaccines against SARS-CoV-2 to end the COVID-19 pandemic. | 2020-09-05 |
| 32887977 | The development of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccines and therapeutics will depend on understanding viral immunity. | 2020-09-05 |
| 32888168 | In this period, one of our group of patients who are challenging us for follow-up and treatment are those who should start or continue to use immunosuppressive therapy. | 2020-09-05 |
| 32888278 | Even though it is a severe acute respiratory syndrome virus, recent reports came with multiple organ effects of SARS-CoV 2, suggesting the virulence potential of this novel Virus to sweep the planet in the absence of a proper vaccine or therapy. […] In this review, we discuss the multi-organ pathophysiology of COVID-19 infection together with the treatment methods adopted and innovative diagnostic methods used. | 2020-09-05 |
| 32888288 | Most of the cases progressed without complications, although one individual presented hypoxemia (minimum SatO2 of 90%) in both episodes, and two, only in the second, one of which required intensive care unit admission, progressing with improvement after medication and receiving noninvasive ventilatory support. | 2020-09-05 |
| 32888360 | Patients with cancer have been impacted by deferral, modification, and even cessation of therapy. […] The European Society for Medical Oncology-Magnitude of clinical benefit scale was applied to systemic-treatment recommendations to support prioritization. […] The SELNET consensus provides a tool for sarcoma multidisciplinary treatment committees during the COVID-19 outbreak. […] The European Society for Medical Oncology-Magnitude of Clinical Benefit scale was applied as support for prioritizing systemic treatment. […] The SELNET consensus provides a practice tool for guidance in the decisions of sarcoma multidisciplinary treatment committees during the COVID-19 outbreak. | 2020-09-05 |
| 32888638 | Potential strategies to improve guideline-directed medical therapy include leveraging non-physician clinicians, solidifying transitions of care, incorporating telehealth solutions, and engaging in comprehensive comorbid disease management via multidisciplinary team structures. | 2020-09-05 |
| 32888676 | All personnel in charge of colorectal surgery units nationwide received a survey (from February to April, 2020) with eight questions divided into three sections-cessation date of colorectal cancer surgeries, number of patients waiting for treatment, and use of neoadjuvant therapy to postpone surgery. […] In addition, 65% of units used or prolonged neoadjuvant therapy in rectal cancer patients and 40% of units performed at least five emergency colorectal cancer surgeries. | 2020-09-05 |
| 32888767 | Coronavirus Disease 2019 (COVID-19) is a dangerous global threat that has no clinically approved treatment yet. | 2020-09-05 |
| 32888796 | A significant proportion of these patients require admission to intensive care units for acute hypoxic respiratory failure and are at an increased risk of developing cardiac arrhythmias. […] Furthermore, avoidance and early recognition of drug interactions, along with prompt treatment, might help improve outcomes in this vulnerable patient population. | 2020-09-05 |
| 32888800 | In some pregnant women, respiratory failure can occur and progress quickly to acute respiratory distress syndrome requiring extracorporeal membrane oxygenation (ECMO) as a rescue therapy. […] Despite a lack of current guidelines on the use of ECMO in pregnant or postpartum women, this support therapy is an effective salvage therapy for patients with cardiac and/or respiratory failure, and is associated with favorable maternal and fetal outcomes. […] Extracorporeal membrane oxygenation should be considered early when conventional therapy is ineffective, and it is essential to refer to ECMO expert centers. | 2020-09-05 |
| 32888840 | Until now, there are no approved treatment against COVID-19. […] Cytokine profile was checked before HCQ initiation and on the 14th day of HCQ treatment. […] Among the six patients, the mean duration from symptom onset to last detectable viral load was 34 ± 12 days, which was similar to those without specific treatment in previous reports. | 2020-09-05 |
| 32888871 | In this review, we systematically compare COVID-19 and SARS in terms of epidemiology, pathogenesis and clinical characteristics and discuss the current treatment approaches, scientific advancements and Chinese experience in fighting the epidemic to combat the novel coronavirus pandemic. | 2020-09-05 |
| 32888875 | The majority (78%) were on anticoagulant therapy or thromboprophylaxis. | 2020-09-05 |
| 32889029 | Surgical masks and filtering facepiece respirator coupons and straps were inoculated with infectious PRCV and submitted to three decontamination treatments, ultraviolet (UV) irradiation, vaporized H2O2, and dry heat treatment. […] This is the first description of stable disinfection of face masks and filtering facepiece respirators contaminated with an infectious SARS-CoV-2 surrogate using UV irradiation, vaporized H2O2 and dry heat treatment. | 2020-09-05 |
| 32889161 | Treatment outcome in COVID-19 months were comparable with that in the pre-COVID-19 months except that limb loss in the chronic limb-threatening ischemia patients was higher. | 2020-09-05 |
| 32889236 | Hence, Tocilizumab can be used as a possible treatment option in patients with COVID-19 induced CRS but needs monitoring for its adverse effects. | 2020-09-05 |
| 32889589 | In the case of coronavirus-19 pneumonia, our experience suggests that the treatment of severe haemoptysis by bronchial artery embolisation is feasible and effective. | 2020-09-05 |
| 32889638 | Two articles propose to advance the use of oxygen to the level of a therapeutic treatment early in the detection of the virus in infected patients by delivering oxygen under elevated pressure in hyperbaric chambers. | 2020-09-05 |
| 32889701 | Currently, there are no treatment options available for the deadly contagious disease, coronavirus disease 2019 (COVID-19). […] In the current scenario, repositioning of the drugs could be considered the new avenue for the treatment of COVID-19. | 2020-09-05 |
| 32889970 | Nonsurgical options are crucial to beginning a treatment plan while elective surgeries are still restricted in many hospitals. […] Medication management and innovative technology, such as smart telephone applications, play a prominent role. | 2020-09-05 |
| 32890029 | The recent coronavirus disease 2019 pandemic has resulted in a significant shortage of HCQ in many countries with possible consequences in the correct treatment of lupus patients. […] Recent evidence reinforces the central role of HCQ in SLE therapy. […] On the contrary, and despite the well established beneficial effects of prolonged regular HCQ therapy, many SLE patients do never take this drug or it is eventually stopped in the setting of severe flares, pregnancy or presumed toxicity. | 2020-09-05 |
| 32890069 | In group 1, nine patients were on chronic oral anticoagulant therapy and one patient was on acetylsalicylic acid (ASA) and clopidogrel. […] During hospitalization, COVID-19 patients received azithromycin and hydroxychloroquine in addition to their ongoing therapy. […] Only the patient on ASA with clopidogrel therapy was transferred to the ICU for mechanical ventilation because of worsening respiratory failure, and subsequently died from cardiorespiratory arrest. […] All other patients on chronic anticoagulant therapy recovered and were discharged. […] Our study suggests that COVID-19 patients on chronic anticoagulant therapy may have a more favorable and less complicated clinical course. | 2020-09-05 |
| 32890139 | The primary outcome was death and secondary outcomes were severe disease, intubation and renal replacement therapy(RRT). […] Among SOT recipients, COVID-19-related treatment with hydroxychloroquine (HCQ) was associated with ten-fold higher hazard of death compared to without HCQ (HR=10.62[1.24-91.09]). […] HCQ for the treatment of COVID-19 among SOT recipients was associated with high mortality and therefore, its role as a treatment modality requires further scrutiny. | 2020-09-05 |
| 32890309 | Anticoagulant therapy improves outcomes in mechanically ventilated patients with COVID-19 and viscoelastic coagulation testing offers an opportunity to tailor anticoagulant therapy based on an individual patient’s coagulation status. […] In this narrative review, we summarize clinical manifestations of COVID-19, mechanisms, monitoring considerations, and anticoagulant therapy. | 2020-09-05 |
| 32890338 | This current opinion report addresses the mechanisms by which CAC may develop, discusses how CAC may worsen lung injury, and treatment strategies under investigation. | 2020-09-05 |
| 32890343 | Additional data were collected according to the different indications for surgical treatment. | 2020-09-05 |
| 32890356 | Nicotine replacement therapy and quitline counseling were provided and no major withdrawal symptoms were declared. | 2020-09-05 |
| 32890396 | To assist structure-based design of vaccines and therapeutics against SARS-CoV-2 and other coronaviruses, we have developed CoV3D, a database and resource for coronavirus protein structures, which is updated on a weekly basis. | 2020-09-05 |
| 32890512 | Practices reported treating an average of 1086 patients per year in 2019 (range, 0-7900) with an average daily treatment volume of 70 patients (range, 5-400). […] On average, practices were treating 68% of their typical volume (range, 10%-95%), with 92% implementing planned treatment postponement for lower risk patients. […] Seventy-four percent used telemedicine for virtual follow-up surveillance, and 15% leveraged telemedicine for on-treatment assessment. […] Despite reported shortages in personal protective equipment, declines in revenue, and reduced patient volumes, practices adapted quickly by refining standard processes of care, implementing recommended safety measures, and employing telemedicine to facilitate treatment continuity. | 2020-09-05 |
| 32890516 | The impact of the COVID-19 pandemic on Latin American radiation therapy services has not yet been widely assessed. […] From May 6 to May 30, 2020, the American Society for Radiation Oncology’s COVID-19 Survey was distributed across Latin America with support of the local national radiation therapy societies. […] A median 8% (1%-90%) decrease in patient volume was reported, with a median of 53 patients (1-490) remaining under treatment. […] Reported delays in treatment for low-risk entities included early stage breast cancer (42.6%), low-risk status prostate cancer (67%), and nonmalignant conditions (42.6%). […] Treatment of COVID-19 patients at designated treatment times and differentiated bunkers were reported in 22.6% and 10.4% of centers, respectively. […] Telehealth initiatives have been started in 64.3% of facilities to date for on-treatment (29.6%) and posttreatment (34.8%) patients. […] Follow-up surveys will be performed to provide dynamic monitoring the pandemic’s impact on radiation therapy services and adoption of ameliorating measures. | 2020-09-05 |
| 32890523 | Among responding patients, 310 were undergoing active treatment and 158 were in follow-up care. […] For patients treated with radiation therapy (RT), 59.9% and 63.4% of the responding patients acknowledged that video consultations would be an important addition to medical care during RT course or after the completion of RT, respectively. | 2020-09-05 |
| 32890524 | Patient feedback was collected at 17 new-patient, 22 on-treatment, and 17 follow-up video visits. […] A lower proportion of on-treatment patients rated their virtual visit as “very satisfactory” (68.2% vs 76.5% for new patients and 82.4% for follow-ups). […] Only 5.9% of the new patients and none of the follow-up patients were dissatisfied, and 27% of on-treatment patients were dissatisfied. […] Telemedicine is a convenient means of delivering care to patients, with some limitations demonstrated for on-treatment patients. | 2020-09-05 |
| 32890525 | Telemedicine was rapidly implemented for initial consultations and radiation treatment planning in the wake of the coronavirus disease 2019 (COVID-19) pandemic. | 2020-09-05 |
| 32890526 | Using a patient undergoing 28-fraction treatment as an example, process maps for traditional in-person and telemedicine-based workflows consisting of discrete steps were created. […] Transitioning to telemedicine reduced provider costs by $586 compared with traditional workflow: $47 at consultation, $280 during treatment planning, $237 during on-treatment visits, and $22 during the follow-up visit. […] Patients saved $170 per treatment course. | 2020-09-05 |
| 32890548 | We used a mobile phone application with artificial intelligence that automatically classifies and analyses the data (ketonuria, diet transgressions, and blood glucose values), making adjustment recommendations regarding the diet or insulin treatment. | 2020-09-05 |
| 32890817 | Multiple sclerosis (MS) patients may also be at risk of the disease and its complications depending on the medication they are taking. | 2020-09-05 |
| 32890921 | Disinfectant Quats have very low vapor pressure, and following the use phase of the products in which they are found, disposal is typically “down-the-drain” to wastewater treatment systems. […] As a result, disinfectant Quats are largely removed during wastewater treatment, and those residues discharged in treated effluent are likely to rapidly bind to suspended solids or sediments, thus mitigating their toxicity. | 2020-09-05 |
| 32890967 | Propolis has also shown promise as an aid in the treatment of various of the comorbidities that are particularly dangerous in COVID-19 patients, including respiratory diseases, hypertension, diabetes, and cancer. | 2020-09-05 |
| 32891073 | Students had high correct response rates in questions asking about transmission method, treatment, zoonotic transmission and medications to be avoided. | 2020-09-05 |
| 32891146 | In this regard, the use of nanotechnology offers new opportunities for the development of novel strategies in terms of prevention, diagnosis and treatment of COVID-19 and other viral infections. | 2020-09-06 |
| 32891160 | Age 8-90 years Both genders Exclusion criteria: Intubated patients on parenteral treatment Allergy to Gum Arabic The study will be conducted in COVID Isolation Centres and Soba University Hospital Khartoum State Sudan. […] Experimental: Intervention Group This arm will receive 100% natural Gum Arabic provided in a powder form in 30-grams-dose once daily for four weeks Placebo Comparator: Control group: This group will be provided with pectin powder provided as one-gram-dose once daily for four weeks Both GA and placebo will be in addition to standard care treatment based on local clinical guidelines. | 2020-09-06 |
| 32891290 | Treatment of COVID-19 is primarily supportive and the role of antiviral agents is yet to be established. […] Chinese, Indian and Iranian traditional medicine, suggests some herbs for prevention, treatment and rehabilitation of the diseases including COVID-19. […] Chinese, Indian and Iranian traditional medicine, suggests some herbs for prevention, treatment and rehabilitation of the diseases including COVID-19. […] Herein, we reviewed the latest updates on traditional medicines proposed for treatment of COVID-19. | 2020-09-06 |
| 32891569 | This technical report will highlight our experience with the use of paracervical blocks (PCBs) and oral multimodal analgesia (MMA) for appropriately selected cervical ICBT cases, allowing for completely clinic-based treatment. 18 of 19 (95%) screened patients were eligible for in-clinic ICBT. […] The excluded patient had significant vaginal fibrosis. 38 of 39 intracavitary implants were successfully transitioned for entirely in-clinic treatment utilizing PCBs and oral MMA (97% success rate). […] One case was aborted due to inadequate analgesia secondary to a significantly delayed case start time (PO medication effect diminished). 95% of patients reported no pain at the conclusion of the procedure. […] In a multidisciplinary effort, we have successfully transitioned many ICBT cases to the clinic with the use of PCB local anesthesia and oral multimodality therapy in direct response to the current pandemic, thereby mitigating exposure risk to patients and staff as well as reducing overall health care burden. | 2020-09-06 |
| 32891582 | Treatment strategies included intravenous immunoglobulin (63%) and intravenous steroids (44%). 29 cases received Infliximab, 47 received IL1 (interleukin) receptor antagonist, and 47 received IL6-receptor antagonist. | 2020-09-06 |
| 32891590 | We report a COVID-19 patient co-infected with Mycoplasma pneumoniae who recovered well after combination therapy. | 2020-09-06 |
| 32891677 | This straightforward method operates with simple proteinase K treatment and repetitive heating steps with a sensitivity of 94.6% in head-to-head comparisons with kit-based isolation methods. | 2020-09-06 |
| 32891745 | In this article, we review current understanding of PE in COVID-19 patients, summarize consensus data regarding the treatment of PE, and propose an algorithm to guide the management of COVID-19 patients with PE. | 2020-09-06 |
| 32892061 | The suggestions for mild (green)category: symptomatic treatment in ward, in moderate (yellow) category: active treatment, semi critical care and oxygen supplementation, in severe (red) category: critical care and intensive care. | 2020-09-06 |
| 32892197 | Key Messages: We propose that there is (1) no evidence that IBD itself increases the risk of SARS-CoV-2 infection, (2) to basically prioritize the control of disease activity of IBD, (3) no need for physicians to suddenly discontinue immunomodulatory or biologic therapy in patients with quiescent IBD, and (4) a need for careful observation of elderly (>60 years old) and IBD patients receiving corticosteroid treatment during the COVID-19 pandemic. | 2020-09-06 |
| 32892275 | The induction therapy containing ixazomib, an oral proteasome inhibitor, has shown favorable efficacy and safety in clinical trials, but its experience in real-life remains limited. […] In routine practice, few patients received ixazomib-based induction therapy due to reasons including (1) patients’ preference on oral regimens, (2) concerns on adverse events (AEs) of other intravenous/subcutaneous regimens, (3) requirements for less center visits, and (4) fears of COVID-19 and other infectious disease exposures. […] With the aim of assessing the real-life effectiveness and safety of ixazomib-based induction therapy, we performed this multi-center, observational study on 85 newly diagnosed multiple myeloma (NDMM) patients from 14 medical centers. […] Different ixazomib-based therapies were applied due to (1) financial burdens or limitations on local health insurance coverage, (2) concerns on treatment tolerance, and (3) drug accessibility issue. […] Patients received a median of 6 (range 1-20) cycles of ixazomib treatment; 56.6% remained on treatment at data cutoff; 15.3% discontinued treatment due to intolerable AEs. […] These results support that the ixazomib-based frontline therapy was highly effective with acceptable toxicity in routine practice and the ixazomib oral regimens could be good alternative options for NDMM patients. | 2020-09-06 |
| 32892293 | To systematically assess the benefits and harms of HCQ for the treatment of COVID-19. […] There was no significant difference in RT-PCR negative conversion between HCQ group and standard treatment (ST) group (RR = 1.11, 95% CI = 0.77-1.59, P = 0.591). […] Death (RR = 1.92, 95% CI = 1.26-2.93, P = 0.003) was distinctly different in HCQ group compared with ST group in the treatment of COVID-19. […] Our meta-analysis demonstrated that there was no robust evidence to support prescribing HCQ as a treatment for COVID-19. | 2020-09-06 |
| 32892311 | The outbreak of coronavirus in the world has led to an uncertainty about treatment of patients with autoimmune disorders because of their weakened immune system coupled with immunosuppressive agents they take which predisposes them to a host of infections. […] In fact, drugs like hydroxychloroquine, dexamethasone, and tocilizumab have been studied for treatment of COVID-19. […] Published evidence to guide treatment decisions are lacking and doubts regarding continuation and initiation of immunosuppressants remain. […] • Maintenance biologic therapy for stable patients should be individualized by the treating physician. | 2020-09-06 |
| 32892325 | The deliveries occurred in a negative pressure isolation room, and the neonates were separated from their mothers immediately after birth for further observation and treatment. | 2020-09-06 |
| 32892337 | Secondary outcomes included ICU length of stay, the proportion of patients receiving mechanical ventilation and renal replacement therapy, and hospital discharge destination. […] Among the 198 patients with definite outcomes, ICU length of stay was 12 (IQR, 6-18) days, 163 (82.3%) received mechanical ventilation, 28 (14.1%) received renal replacement therapy, 60 (30.3%) died, 62 (31.3%) were discharged home, 47 (23.7%) were discharged to ward, and 29 (14.6%) were discharged to another health care facility. | 2020-09-06 |
| 32892459 | Hair loss treatment involves both surgical intervention and nonsurgical therapies such as pharmaceuticals, haircare products, vitamins, and low-level laser therapy (LLLT). […] The COVID-19 pandemic initially negatively affected hair loss treatment searches, which have since returned to, and surpassed, pre-pandemic levels. […] A weak economy and coronavirus fears may persuade consumers to turn to cheaper hair loss treatment alternatives. | 2020-09-06 |
| 32892460 | Our findings highlight the impact of COVID-19 on older adults’ mental health, greater demand for inpatient psychogeriatric services in COVID-19 than in SARS, and the importance of maintaining support for community-living older adults, in particular those with dementia, and their caregivers in reducing the needs for inpatient psychiatric treatment during the pandemic. | 2020-09-06 |
| 32892465 | In Wuhan, haemophilia treatment (for bleeding, prophylaxis, multidisciplinary team care, immune tolerance induction) and patient education were severely affected, while the challenges in Tianjin were less. […] Consequently, many downgraded their treatment regimens resulting in increased bleeding episodes. | 2020-09-06 |
| 32892477 | Patients’ demographic characteristics, comorbidities, clinical manifestations of COVID-19 infection, medication use, and history of lung malignancy were retrieved from their medical history. | 2020-09-06 |
| 32892500 | The raw case fatality rate (CFR, the reported number of COVID-19 deaths divided by the total number of cases) is an important indicator to quantify the severity or treatment efficacy. | 2020-09-06 |
| 32892516 | The pandemic had a significant negative impact on rheumatology visits in 82% of cases, access to hydroxychloroquine (47%), and chronic medication persistency (28%). […] The negative impact on rheumatology visits was associated with female gender, country, medication non-persistency, isolation due to COVID-19, and impact on mental health. […] Therefore, an action plan, including establishing a telemedicine platform, securing drug availability, and promoting medication persistence through the appropriate communication channels, is strongly recommended. | 2020-09-06 |
| 32892540 | This study aimed to investigate the clinical impact of a low molecular weight heparin (LMWH) treatment on the clinical course of COVID-19. […] Improvement in the patients was compared before and after treatment. […] LMWH treatment group demonstrated better laboratory findings, including a recovery in the lymphocyte count, CRP, and D-dimer results. | 2020-09-07 |
| 32892615 | Aim of this paper is to summarize current evidence about vascular involvement in COVID-19 disease and potential antithrombotic therapy. | 2020-09-07 |
| 32892980 | The extraordinary impact of COVID-19 pandemic on Spanish hospitals has led to a redistribution of resources for the treatment of these patients, with a decreased capacity of care for other common diseases. […] The aim of the present study is to analyse how this situation has affected the treatment of cholecystitis and cholelythiasis. […] Conservative treatment for acute cholecystitis has been selected in 90% (previously 18%), and if operated, 95% have been performed laparoscopically. | 2020-09-07 |
| 32893003 | Protective factors, such as reframing coping, may mitigate the risk of job loss on child maltreatment. […] The current study investigated factors associated with child maltreatment during the COVID-19 pandemic, including parental job loss, and whether cognitive reframing moderated associations between job loss and child maltreatment. […] Job loss during the COVID-19 pandemic is a significant risk factor for child maltreatment. […] Reframing coping may be an important buffer of this association on physical abuse and presents implications for maltreatment prevention. | 2020-09-07 |
| 32893047 | In the context of the pandemic, buprenorphine prescribers quickly transitioned to providing telemedicine visits in high volume; nonetheless, there are still many unknowns, including the quality and safety of widespread use of telemedicine for OUD treatment. | 2020-09-07 |
| 32893062 | The pandemic necessitated a triage of those patients whose treatment should be expedited, delayed, or avoided, and may persist with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) in circulation. | 2020-09-07 |
| 32893123 | While clinical studies and basic research on a treatment for COVID-19 are ongoing around the world, no treatment has yet been proven to be effective. […] Hence, hydroxychloroquine with nafamostat mesylate might be a treatment option for severe COVID-19. | 2020-09-07 |
| 32893129 | We proposed that trauma patterns would change alongside these changes and maintaining existing standards of treatment would require dedicated planning and structures. […] Maintaining existing standards of treatment requires dedicated planning. | 2020-09-07 |
| 32893160 | Although the use of corticosteroids is not recommended in the World Health Organization statement for the treatment of coronavirus disease 2019 (COVID-19), steroid therapy may be indicated for critical cases in specific situations. […] Here, we report the successful treatment of 11 cases of severe COVID-19 pneumonia with favipiravir and methylprednisolone. | 2020-09-07 |
| 32893231 | MSICH can occur as a fatal complication of COVID-19, and this should be considered when providing treatment. | 2020-09-07 |
| 32893415 | Inclusion criteria included an evaluation of CH technologies for supportive care for families/caregivers affected by paediatric cancer at any stage of treatment or survivorship. […] Intervention areas included psycho-social (n = 6), health and information provision (n = 8) and palliative care (n = 2). | 2020-09-07 |
| 32893508 | We included questions about job status changes, exercise, medication use, disease activity (by the Bath Ankylosing Spondylitis Disease Activity Index [BASDAI]), and psychological factors (stress, depressive symptoms, and anxiety). | 2020-09-07 |
| 32893524 | As a result, acute treatment for ischemic stroke was delayed. | 2020-09-07 |
| 32893632 | So far, no specific treatment to this viral infection has been developed and the emergency still requires an efficient intervention. | 2020-09-07 |
| 32893725 | Notably, 21.43% of patients discontinued their treatment due to fear of COVID-19 and experienced disease recurrence. […] Although there was no significant difference in anxiety and depression between the groups, it is recommended to provide psychiatric counseling opportunities to morphea patients to improve treatment outcomes during this pandemic. | 2020-09-07 |
| 32894024 | ARDS: acute respiratory distress syndrome; aOR: adjusted odds ratio; ALT: alanine transferase; ALIMA: Alliance for International Medical Action; AST: aspartate transaminase; BUN: blood urea nitrogen; CNS: central nervous system; CUBE: chambre d’urgence biosécurisée pour épidémie; COVID-19: coronavirus disease 2019; Ct: cycle threshold; DRC: Democratic Republic of Congo; ETC: ebola treatment centre; ETU: ebola treatment unit; EBOV: ebola virus; EVD: ebolavirus disease; FEAST: fluid expansion as supportive therapy; GP: glycoprotein; IV: intravenous; MEURI: monitored emergency use of unregistered interventions; NETEC: National Ebola Training and Education Centre; NP: nucleoprotein; ORS: oral rehydration solution; PALM: Pamoja Tulinde Maisha; PREVAIL: Partnership for Research on Ebola Virus in Liberia; PPE: personal protective equipment; PCR: polymerase chain reaction; PEP: post-exposure prophylaxis; RDTs: rapid diagnostic tests; RT: reverse transcriptase; RNA: ribonucleic acid; UNICEF: United Nations International Children’s Emergency Fund; USA: United States of America; WHO: World Health Organization. | 2020-09-07 |
| 32894562 | The COVID-19 pandemic demands a reassessment of head and neck oncology treatment paradigms by posing several challenges for oncology services, with unprecedented pressure on the regional health care system. | 2020-09-07 |
| 32894566 | The use of uridine, which preserves the structure of pulmonary alveoli and the air-blood barrier of the lungs in the course of experimental severe hypoxia, and dihydroquercetin, an effective free radical scavenger, is promising for the treatment of COVID-19. | 2020-09-07 |
| 32894567 | Lopinavir/ritonavir has been used for the treatment of Severe Acute Respiratory Syndrome (SARS) and Middle East Respiratory Syndrome (MERS) coronavirus infections. […] We performed a systematic review of the literature regarding the use of lopinavir/ritonavir for the treatment of these three infections. […] We systematically searched the PubMed database from inception to April 30th, 2020, to identify in-vitro and animal studies and any reports of human use of lopinavir/ritonavir for the treatment of SARS, MERS and COVID-19. | 2020-09-07 |
| 32894820 | Decisions to alter, delay or omit treatment during this period should consider both the risk of the cancer and of COVID-19 to the patient, as well as resource constraints. | 2020-09-07 |
| 32894838 | Indeed, the 2 patients we describe remained systemically well for the majority of their inpatient stay, which would support the hypothesis that for these patients, AKI was caused by a cytopathic viral effect, rather than that of a cytokine storm or acute tubular necrosis caused by prolonged hypovolaemia or the effect of medication known to exacerbate AKI. | 2020-09-07 |
| 32894907 | Pirfenidone and Nintedanib had been approved for the treatment of idiopathic pulmonary fibrosis(IPF), showing effectiveness on non-IPF pulmonary fibrosis as well. | 2020-09-08 |
| 32894909 | Integrated the existing treatment experience and relevant literature evidence, we recommend the evaluation and intervention of respiratory rehabilitation in the two stages of discharge ICUto ward and home. | 2020-09-08 |
| 32895056 | The intervention group will receive the anticoagulant bivalirudin intravenously with a target aPTT of 45-70 sec for three days while the control group will stay on the standard treatment with low-molecular-weight heparins /unfractionated heparin subcutaneously (see scheme in Additional file 1). […] All other treatment will be unchanged and left to the attending physicians. […] After inclusion, the patients will be randomized using a closed envelope method into the conventional treatment group, which uses the standard strategy and the experimental group which receives anticoagulation treatment with bivalirudin using an allocation ratio of 1:1. […] We expect the treatment will improve this by 30%. | 2020-09-08 |
| 32895074 | We further recommend that providers in Ebola treatment hospitals be employed to train and educate providers in frontline hospitals in a ‘train-the-trainer’ model. | 2020-09-08 |
| 32895105 | Objective To explore the optimal therapy time for the treatment of severe coronavirus disease 2019(COVID-19)by traditional Chinese medicine(TCM)and its influence on the therapeutic effect and prognosis. […] Conclusion Early TCM therapy within three days after a diagnosis of severe COVID-19 can shorten the length of hospital stay,duration of ICU stay,and time to negativity and decrease intubation rate. | 2020-09-08 |
| 32895128 | The Diagnostic and Treatment Protocol for COVID-19 (Trial Version 6) in China recommends chloroquine phosphate for the first time as an anti-coronavirus trial drug. […] As a classic drug for treatment of malaria and rheumatism, chloroquine phosphate has been used clinically for more than 80 years, and has also shown good results in the treatment of various viral infections. […] As the plasma drug concentration varies greatly among different races and individuals and due to its narrow treatment window, chloroquine in likely to accumulate in the body to cause toxicity. […] Among the treatment regimens recommended for COVID-19, reports concerning the safety of a short-term high-dose chloroquine regimen remain scarce. […] In this review, the authors summarize the current research findings of chloroquine phosphate in the treatment of COVID-19, and examine the pharmacokinetic characteristics, antiviral therapy, the therapeutic mechanism and safety of chloroquine. | 2020-09-08 |
| 32895172 | To explore the pharmacologically active ingredients in Toujie Quwen granules (TJQW) for treatment of coronavirus disease 2019 (COVID-19) in light of systemic pharmacology. […] We performed database search, literature mining and drug-like index screening to identify the bioactive components in TJQW, the positive drugs for disease treatment and their therapeutic targets. […] The material basis of TJQW for COVID-19 treatment was explained in multi-pathway, multi-component and multi-target perspectives. | 2020-09-08 |
| 32895195 | The demographic data, clinical manifestations and signs, laboratory findings, treatment measures and clinical outcomes were obtained from electronic medical records to compare the clinical characteristics and outcomes between the two groups. […] Six (30%) of the patients received invasive mechanical ventilation and continued renal replacement therapy but eventually died. | 2020-09-08 |
| 32895247 | While prone positioning (PP) is an established therapy in mechanically ventilated patients with acute respiratory distress syndrome (ARDS), its role in conscious patients is less well defined. […] From our experience in a dedicated COVID-19 respiratory high care unit, PP alongside CPAP therapy was feasible, tolerated, safe and improved oxygenation. | 2020-09-08 |
| 32895254 | While guidelines remain unclear, IVIg may be of potential benefit in the treatment of COVID-19-associated meningoencephalitis. | 2020-09-08 |
| 32895296 | Individualized prediction of mortality risk can inform the treatment strategy for patients with COVID-19 and solid tumors and potentially improve patient outcomes. […] Multivariate logistic regression revealed that increasing age (OR=1.08, 95% CI 1.00 to 1.16), receipt of antitumor treatment within 3 months before COVID-19 (OR=28.65, 95% CI 3.54 to 231.97), peripheral white blood cell (WBC) count ≥6.93 ×109/L (OR=14.52, 95% CI 2.45 to 86.14), derived neutrophil-to-lymphocyte ratio (dNLR; neutrophil count/(WBC count minus neutrophil count)) ≥4.19 (OR=18.99, 95% CI 3.58 to 100.65), and dyspnea on admission (OR=20.38, 95% CI 3.55 to 117.02) were associated with elevated mortality risk. […] Increasing age, receipt of antitumor treatment within 3 months before COVID-19 diagnosis, elevated WBC count and dNLR, and having dyspnea on admission were independent risk factors for mortality among patients with COVID-19 and solid tumors. | 2020-09-08 |
| 32895375 | At the COVID-19 pandemic onset, when individual-level data of COVID-19 patients were not yet available, there was already a need for risk predictors to support prevention and treatment decisions. | 2020-09-08 |
| 32895447 | Here, we study the response of Vero cells to TIZ treatment and unveil possible mechanisms for its antimicrobial effect, using a label-free proteomic approach (LC/MS/MS) analysis to compare the proteomic profile between untreated- and TIZ-treated cells. […] The decreased levels of FASN, HNRNPH and HNRNPK with the treatment appear to be important for antiviral activity. | 2020-09-08 |
| 32895595 | The coronavirus (COVID-19) outbreak, and the resultant lock-downs and cross-border travel restrictions have reinvigorated public debates about the vulnerability of the global migrants, together with the responsibility of the States to ensure dignified treatment of migrants. | 2020-09-08 |
| 32895611 | A COVID-19 patient was diagnosed with acute acalculous cholecystitis and a multidisciplinary team decided to perform a percutaneous transhepatic biliary drainage (PTBD) as the first treatment. […] Although the lack of evidence and guidelines about the management of patient with acute cholecystitis during COVID-19 pandemic, laparoscopic cholecystectomy, at most preceded by PTGBD on high surgical risk patients, remains the gold standard for the treatment of acute cholecystitis on COVID-19 patients. | 2020-09-08 |
| 32895623 | This crisis is unlikely contained in the absence of effective therapeutics or vaccine. | 2020-09-08 |
| 32895629 | Thus, the efficient treatment of wastewater is a matter of utmost importance. […] The conventional wastewater treatment processes demonstrate a wide variability in absolute removal of viruses from wastewater, thereby posing a severe threat to human health and environment. […] The fate of SARS-CoV-2 in the wastewater treatment plants and its removal during various treatment stages remains unexplored and demands immediate attention; particularly, where treated effluent is utilised as reclaimed water. | 2020-09-08 |
| 32895639 | We recorded patients’ epidemiological, clinical features, and follow-up data after discharging in order to improve the awareness and treatment of children with COVID-19. | 2020-09-08 |
| 32895645 | The inappropriately elevated levels of inflammatory cytokines in COVID-19 patients is similar to cytokine release syndrome (CRS) observed in cell therapy patients. […] We sought to describe outcomes in a series of severely ill patients with COVID-19 CRS following treatment with anti-IL-6/IL-6-Receptor (anti-IL-6/IL-6-R) therapy, including tocilizumab or siltuximab. […] At our academic community medical center, we formed a multi-disciplinary committee for selecting severely ill COVID-19 patients for therapy with anti-IL-6 or IL-6-R agents. […] Clinical responses to anti-IL-6/IL-6-R therapy were accompanied by significant decreases in temperature, oxygen requirement, CRP, IL-6, and IL-10 levels. […] Based on these data, we believe anti-IL-6/IL-6-R therapy can be effective in managing early CRS related to COVID-19 disease. […] Further study of anti-IL-6/IL-6-R therapy alone and in combination with other classes of therapeutics is warranted and trials are underway. | 2020-09-08 |
| 32895676 | Since 1983, etoposide (VP-16) is being used in frontline cancer therapy against various cancer types, such as small cell lung cancer and testicular cancer. […] The treatment aims at dampening the cytokine storm and is based on etoposide in the case of central nervous system. […] Almost all podophyllotoxin derivatives, including the FDA-approved drugs VP-16 and teniposide, were seriously limited in clinical therapy due to systemic toxicity, drug resistance, and low bioavailability. […] This review focuses on the current clinical treatment of PTOXs and the prospective analysis for improving druggability in the rational design of new generation PTOX-derived drugs. | 2020-09-08 |
| 32895747 | Data are rapidly evolving and different studies on treatment options are showing contradictory results. | 2020-09-08 |
| 32895799 | Five typical surgical intervention techniques (mechanical stress with a passive instrument with and without suction, CO2 laser treatment, drilling and bipolar electrocoagulation) were examined and compared regarding resulting particle release. […] In addition, relevant amounts of aerosol were released during electrocoagulation (79.6% of the maximum flue gas emission during laser treatment). […] Especially electrocautery is frequently used for emergency treatment, e.g., nose bleeding. | 2020-09-08 |
| 32895900 | Nevertheless, MSCs have antiviral properties and have been used in the treatment of various viral infections in the last years. […] Finally, we argue that MSC-based therapy may be a promising therapeutic strategy for severe COVID-19 and other emergent respiratory tract viral infections, beyond the viral infection diseases in which MSCs have already been clinically applied. | 2020-09-08 |
| 32896184 | The Adaptive COVID-19 treatment trials (ACTT1) trial showed that remdesivir may shorten recovery and decrease mortality in severe COVID-19 without increasing adverse effects. […] The trial is continuing, and the final data are eagerly awaited to determine whether remdesivir is a game-changing remedy or a ripple in the ongoing search for a medicine for the treatment of COVID-19. | 2020-09-08 |
| 32896189 | We assessed whether delayed surgery improves hip joint function and reduces major complications better than nonoperative therapy. […] Results - Of the 145 hip fracture patients 108 (median age 72; 70 females) received delayed surgery and 37 (median age 74; 20 females) received nonoperative therapy. […] Interpretation - In hip fracture patients, delayed surgery compared with nonoperative therapy significantly improved hip function and reduced various major complications. | 2020-09-08 |
| 32896203 | This article describes the current scenario in Brazil which has exposed the shortage of professionals and resources and reinforces the need for professional recognition, especially of those working in intensive care units. | 2020-09-08 |
| 32896226 | Till date, there is no vaccination or drugs been approved for the treatment by the World Health Organisation. | 2020-09-08 |
| 32896292 | The efficacy and safety of azithromycin in the treatment of COVID-19 remain uncertain. […] All patients received hydroxychloroquine (400 mg twice daily for 10 days) because that was part of standard of care treatment in Brazil for patients with severe COVID-19. […] The primary outcome, assessed by an independent adjudication committee masked to treatment allocation, was clinical status at day 15 after randomisation, assessed by a six-point ordinal scale, with levels ranging from 1 to 6 and higher scores indicating a worse condition (with odds ratio [OR] greater than 1·00 favouring the control group). […] Safety was assessed in all patients according to which treatment they received, regardless of original group assignment. […] In patients with severe COVID-19, adding azithromycin to standard of care treatment (which included hydroxychloroquine) did not improve clinical outcomes. | 2020-09-08 |
| 32896310 | The objective of this study was to provide an evidence-based review of the associated pathways and potential treatment of the hyperinflammatory state associated with severe acute respiratory syndrome coronavirus 2 infection. […] Recognition of at-risk patients could permit early institution of aggressive intensive care and antiviral and immune treatment to reduce the complications related to this proinflammatory state. […] This review highlights our current state of knowledge of immune mechanisms and targeted immunomodulatory treatment options for the current coronavirus disease 2019 pandemic. | 2020-09-08 |
| 32896750 | The global panic of the novel coronavirus disease 2019 (COVID-19) triggered by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has led to an urgent requirement for effective therapy. […] COVID-19 infection, especially in severely ill patients, is likely to be associated with immune dysregulation, prompting the development of novel treatment approaches. […] Sixty-six publications and 111 clinical trials were recognized as eligible, reporting the efficacy of the immunomodulatory agents, including corticosteroids, hydroxychloroquine, passive and cytokine-targeted therapies, mesenchymal stem cells, and blood-purification therapy, in COVID-19 patients. […] However, there is no consensus on the optimal therapy for COVID-19, reflecting that the immunomodulatory therapies still warrant further investigations. | 2020-09-08 |
| 32896833 | Of the nearly 1700 patients with CLD who attended a follow-up visit at our Liver Unit, none contracted COVID-19, and there was no need to alter treatment schedules. | 2020-09-08 |
| 32896863 | Early intervention with dysphagia therapy and speech therapy and ventilator-compatible speak-ing valves, provided within an interprofessional collaborative team, can mitigate the potentially negative consequences of prolonged intubation, long-term use of cuffed tracheostomy, and post intensive care syndrome resulting from Covid-19. […] Such a treatment approach can be used to address what is important to patients: to be able to speak with family and friends, eat what they want, and breathe spontaneously. | 2020-09-08 |
| 32897211 | To explore the target, signaling pathways and their biological functions of QingfeiPaidu Decoction in the treatment of COVID-19 based on network pharmacology and molecular docking technology. | 2020-09-08 |
| 32897278 | We systematically searched 11 electronic databases until 29 May 2020 for studies in English reporting original data on AKI and kidney replacement therapy (KRT) in hospitalized COVID-19 patients. […] Additional studies are needed to better understand the underlying mechanisms and optimal treatment of AKI in these patients. | 2020-09-08 |
| 32897296 | This was a prospective, single-center cohort study of 50 patients admitted to the neuroscience or coronavirus disease 2019 (COVID-19) intensive care units at Yale New Haven Hospital in New Haven, Connecticut, from October 30, 2019, to May 20, 2020. […] Demographic, clinical, radiological, and treatment data were collected and analyzed. | 2020-09-08 |
| 32897518 | It is important to take note of what ongoing clinical trials on chloroquine and hydroxychloroquine can eventually tell us about the use of antimalarials and other anti-inflammatory agents, not only for the treatment of COVID-19, but also for neurovascular disorders such as stroke and vascular dementia. | 2020-09-08 |
| 32897543 | To explore the role of thymosin drugs in the prevention of novel coronavirus disease (COVID-19), we analyzed the preventive effects of different medication timings on health medical staff, and then provided recommendations for pharmaceutical monitoring of thymus drugs. | 2020-09-08 |
| 32897736 | Discussions on the Q&A platform reached a substantial number of oncologists throughout the nation and may help oncologists to modify their treatment in real time with the rapidly evolving COVID-19 pandemic. | 2020-09-08 |
| 32897764 | One prior report suggested that use of androgen deprivation therapy (ADT), which downregulates TMPRSS2, may protect men with prostate cancer from infection. | 2020-09-08 |
| 32897885 | Understanding outcomes and immunologic characteristics of cellular therapy recipients with SARS-CoV-2 is critical to performing these potentially life-saving therapies in the COVID-19 era. […] In this study of recipients of allogeneic (Allo) and autologous (Auto) hematopoietic cell transplant and CD19-directed chimeric antigen receptor T cell therapy (CAR-T) at Memorial Sloan Kettering Cancer Center, we aimed to identify clinical variables associated with COVID-19 severity and assess lymphocyte populations. […] We identified 77 SARS-CoV-2 + cellular therapy recipients (Allo = 35, Auto = 37, CAR-T = 5; median time from cellular therapy 782 days (IQR 354,1611). | 2020-09-08 |
| 32897937 | This study examines the influence of resilience on the impact of COVID-related stress and enforced lockdown on mental health, drug use and treatment adherence among people living with HIV (PLWH) in Argentina. […] Participants completed an anonymous online survey to evaluate the impact of COVID-19 on economic disruption, resilience, mental health outcomes (depression, anxiety, stress, loneliness), adherence to HIV treatment, and substance use. […] Participants reported less than excellent adherence to medication (33%), disruption to mental health services (11%), and disruption to substance abuse treatment (1.3%) during lockdown. […] Results highlight PLWH’s capacity to adhere to treatment in challenging circumstances and the importance of developing resilience skills for better coping with stress and adversity. | 2020-09-08 |
| 32898149 | Secondary outcomes included hospitalization, intensive care unit (ICU) admission, mechanical ventilation, and acute renal replacement therapy. […] In the matched analyses, treatment with NSAIDs was not associated with 30-day mortality (RR 1.02, 95% CI 0.57 to 1.82, p = 0.95; RD 0.1%, 95% CI -3.5% to 3.7%, p = 0.95), risk of hospitalization (RR 1.16, 95% CI 0.87 to 1.53, p = 0.31; RD 3.3%, 95% CI -3.4% to 10%, p = 0.33), ICU admission (RR 1.04, 95% CI 0.54 to 2.02, p = 0.90; RD 0.2%, 95% CI -3.0% to 3.4%, p = 0.90), mechanical ventilation (RR 1.14, 95% CI 0.56 to 2.30, p = 0.72; RD 0.5%, 95% CI -2.5% to 3.6%, p = 0.73), or renal replacement therapy (RR 0.86, 95% CI 0.24 to 3.09, p = 0.81; RD -0.2%, 95% CI -2.0% to 1.6%, p = 0.81). […] Use of NSAIDs was not associated with 30-day mortality, hospitalization, ICU admission, mechanical ventilation, or renal replacement therapy in Danish individuals who tested positive for SARS-CoV-2. | 2020-09-08 |
| 32898238 | Therefore, immune sera with high neutralizing activity must be carefully selected for plasma therapy of zoonotic coronavirus infection. | 2020-09-08 |
| 32898468 | Convalescent plasma (CP) therapy is a type of adaptive immunity that has already been found to be effective in confronting several infectious diseases from the last two decades. […] For example, CP therapy was used in the treatment of viral-induced diseases like SARS-CoV epidemics, Middle East respiratory syndrome coronavirus (MERS-CoV) pandemics, Ebola epidemics and H1N1 pandemic. […] In this review, we have mainly focused on the therapeutic role of CP therapy and its neutralizing effect to fight against the COVID-19 outbreak. | 2020-09-08 |
| 32898672 | In the relatively small subgroup with intensive care treatment (n = 19), patients without contact with small children were overrepresented. | 2020-09-08 |
| 32898806 | Infected patients typically receive their treatment in specific isolation wards, where they are confined for at least 14 days. | 2020-09-08 |
| 32898838 | The review was narrative, describing for each treatment the mechanism(s) of action, tolerability, in vitro and in vivo evidence of the effects against SARS-CoV-2 and whether the product had been marketed. […] No treatment has been tested against SARS-CoV-2 in randomized controlled clinical trials thus far. | 2020-09-08 |
| 32898875 | Sepsis accounts for mortality for almost 50% of global children under 5 years of age.Over the past 50 years, there have been many advances in the diagnosis, prevention, and treatment of neonatal infections. […] From a therapeutic stand point, there have been a variety of antibiotics, antifungals, and antiviral agents, better approaches to prevent sepsis, specific immunotherapy, for example, respiratory syncytial virus (RSV); bundled approach to prevention of deep-line infection and better antibiotic stewardship, leading to earlier discontinuation of antibiotic therapy.Hand hygiene remains the benchmark and gold standard for late-onset sepsis prevention. […] Future treatment options might include stem cell therapy, other antimicrobial protein and peptides, and targeting of pattern recognition receptors in an effort to prevent and/or treat sepsis in this vulnerable population. […] · Future treatments may include newer antibiotics/antivirals and stem cell therapy.. | 2020-09-08 |
| 32898894 | Alertness to changes in COVID-19 reproduction rates might be required until effective antiviral therapy or vaccination is available. | 2020-09-08 |
| 32898993 | Knowledge regarding the detection, diagnosis, treatment, and follow-up of COVID-19-associated neurological damage is still limited. […] A further 18 days of routine antiviral therapy, immunoglobulin therapy (10 g per day for 5 days), and antipsychotic drug treatment were administered. | 2020-09-09 |
| 32898996 | At present, there are no specifically approved therapeutic agents or vaccines for its treatment. […] Previous studies have shown that the convalescent plasma therapy (CPT) is effective in patients with COVID-19. […] The time of initiating the CPT may be an important factor affecting its efficacy, and its therapeutic effect in the treatment of COVID-19, in the late stage, is limited. | 2020-09-09 |
| 32899009 | SARS-CoV-2/HIV-1-coinfected female patient under darunavir/cobicistat regimen received a 7-days hydroxychloroquine therapy. […] The severe pneumonia observed in SARS-CoV-2/HIV-1-positive patient under protease inhibitors was reversed by a 7-days hydroxychloroquine therapy. […] At the end of treatment, on day 7, patient reported resolution of fever, normalization of respiratory rate (14 breaths/min), and improved oxygen arterial pressure with a FiO2 of 30%. | 2020-09-09 |
| 32899063 | Due to the complicated Pathogenesis, high infectivity and high fatality rate of COVID-19, there is currently no effective treatment for such epidemic disease. […] Traditional Chinese medicine has a long clinical history for the prevention and treatment of this kind of acute infectious disease. […] Effective rate of clinical symptoms, treatment time were secondary outcomes. | 2020-09-09 |
| 32899231 | We also review other potential treatment strategies and suggest novel synthetic and natural compounds that may have the potential for future development in clinic. | 2020-09-09 |
| 32899381 | Novel and innovative therapies such as advanced therapy medicinal products (ATMPs) are still in early development. […] This review will examine selected respiratory and pulmonary diseases, present an overview of the therapeutic potential of cell therapy and finally provide insight into potential routes of administration, with a focus on aerosol-mediated ATMP delivery. | 2020-09-09 |
| 32899439 | The observation that the severest COVID-19 patients are more likely to have a history of hypertension, diabetes and/or cardiovascular disease and receive Renin-Angiotensin-System (RAS) inhibitor treatment raised the hypothesis that RAS-unbalancing may have a crucial role. | 2020-09-09 |
| 32899785 | ILs may further be combined with other therapeutic strategies, such as phage or lysine therapy, enhancing the therapeutic arsenal needed to fight this worldwide problem of antibacterial resistance. […] Thus, the use of ILs as antibiotics by themselves or together with phage therapy and lysine therapy are promising alternatives against pathogenic microorganisms, and may have the possibility to be used in new ways in order to restrain uncontrolled infections. | 2020-09-09 |
| 32899835 | Knowledge about the effect of stress in response to a pandemic is important for developing treatment and prevention strategies for stress, depression and health-related anxiety. | 2020-09-09 |
| 32899935 | They have already caused millions of deaths, and the regions where malaria is endemic are at risk of further suffering from the consequences of COVID-19 due to mutual side effects, such as less access to treatment for patients with malaria due to the fear of access to healthcare centers leading to diagnostic delays and worse outcomes. | 2020-09-09 |
| 32899996 | The development of FKS-associated pan-echinocandin resistance in the C. glabrata isolated from the patient after 13 days of caspofungin treatment aggravated the situation. […] The patient died of septic shock shortly before the prospect of receiving potentially effective antifungal therapy. | 2020-09-09 |
| 32900008 | Future studies are needed to examine the response to anti-viral treatment as well as long-term renal outcomes in patients with AKI. | 2020-09-09 |
| 32900168 | Treatment with corticosteroids for COVID-19 and ARDS (acute respiratory distress syndrome) is controversial and has generally not been recommended. | 2020-09-09 |
| 32900176 | While awaiting vaccines or documented specific therapeutic agents, several alternative treatment options are under investigation. […] A SARS-CoV-2 test was not performed immediately before transfusion and the complexity of intensive care treatment makes it difficult to draw any conclusions on the potential effectiveness of this treatment. | 2020-09-09 |
| 32900341 | In an attempt to fulfill the demand for prophylactic and treatment measures to intercept the ongoing outbreak, the drug development process is facing several obstacles and renaissance in clinical trials, including vaccines, antivirals, immunomodulators, plasma therapy, and traditional medicines. | 2020-09-09 |
| 32900372 | When designing a clinical trial, explicitly defining the treatment estimands of interest (that which is to be estimated) can help to clarify trial objectives and ensure the questions being addressed by the trial are clinically meaningful. […] We suggest that treatment effects should usually be measured as differences in proportions (or risk or odds ratios) for outcomes such as death and requirement for ventilation, and differences in means for outcomes such as the number of days ventilated. […] Finally, we suggest that discontinuation of randomised treatment should be handled from a treatment policy perspective, where non-adherence is ignored in the analysis (i.e. intention to treat). | 2020-09-09 |
| 32900426 | Nasal high flow, non-invasive ventilation, and invasive ventilation with intubation should be carried out in a stepwise treatment strategy, under appropriate intensive-care monitoring and with the observance of all relevant anti-infectious precautions. | 2020-09-09 |
| 32900518 | The prevalence of malnutrition and the provided nutritional therapy were evaluated in all the patients with SARS-CoV-2 infection (COVID-19) hospitalized in a 3rd level hospital in Italy. […] A total of 268 patients was evaluated; intermediate care units (IMCUs, 61%), sub-intensive care units (SICUs, 8%), intensive care units (ICUs, 17%) and rehabilitation units (RUs, 14%): BMI: <18.5, 9% (higher in RUs, p = 0.008) and ≥30, 13% (higher in ICUs, p = 0.012); WL ≥ 5%, 52% (higher in ICUs and RUs, p = 0.001); CRP >0.5: 78% (higher in ICUs and lower in RUs, p < 0.001); Nutritional risk and malnutrition were present in 77% (higher in ICUs and RUs, p < 0.001) and 50% (higher in ICUs, p = 0.0792) of the patients, respectively. | 2020-09-09 |
| 32900597 | Coronavirus disease 2019 (COVID-19) is a disease spreading rapidly in Sudan, the rest of the African continent and the world with no known definitive treatment or vaccines. […] However, among many treatment interventions being tested globally, beneficial effects and clinical improvements have been reported when convalescent plasma is used for treating COVID-19 patients. […] This protocol was deduced based on previously published reports and studies that evaluated and tested convalescent plasma as a prospective therapy for COVID-19 patients. […] Altogether, we prepared a treatment protocol that is tailored to the context of Sudan to be adopted by Sudan’s health authority. | 2020-09-09 |
| 32900659 | Although extracorporeal membranous oxygenation (ECMO) is sometimes used in critically patients with COVID-19, ECMO is only an adjunct, not the main treatment. […] We decided to continue ECMO therapy and replaced the circuit. […] In conclusion, viral load measurement by RT-PCR may be one of the indicators for promoting the treatment of severe COVID-19 patients. | 2020-09-09 |
| 32900666 | The principle of plasma therapy can be used for prophylaxis and treatment purpose. […] In view of non-availability of suitable vaccine for prevention or no established definitive therapy for SARS-CoV-2, plasma therapy is gaining importance in a current pandemic as one of the treatment options for the treatment of COVID-19. […] Although, it has been reported to be an effective approach in various preliminary studies, convalescent plasma (CP) therapy has several limitations. […] In this mini review, an attempt has been made to review positive aspects, negative aspects and various limitations of the CP therapy for COVID-19 cases. […] The results of various studies show that CP therapy may be thought of one of the alternatives but while considering it as a therapeutic approach, in light of beneficial effects, the negative aspects and limitations are to be taken into consideration before its administration as a therapeutic agent. | 2020-09-09 |
| 32900750 | His initial treatment included steroids for concern for Pneumocystis jiroveci pneumonia, although this was later excluded as the diagnosis. | 2020-09-09 |
| 32900781 | We determined the clinical characteristics and treatment outcomes of patients diagnosed with COVID-19 in Uganda. […] Outcomes did not differ by HCQ treatment status in line with other concluded studies on the benefit of using HCQ in the treatment of COVID-19. | 2020-09-09 |
| 32900822 | Animal models recapitulating human COVID-19 disease, especially with severe disease, are urgently needed to understand pathogenesis and evaluate candidate vaccines and therapeutics. […] We evaluated the protective efficacy of a neutralizing monoclonal antibody and found that pretreatment, even in immunosuppressed animals, limited infection. | 2020-09-09 |
| 32900875 | This statement updates the recommendations of the American Academy of Pediatrics for the routine use of influenza vaccine and antiviral medications in the prevention and treatment of influenza in children during the 2020-2021 season.The American Academy of Pediatrics (AAP) recommends routine influenza immunization of all children without medical contraindications, starting at 6 months of age. […] Any licensed, recommended, age-appropriate vaccine available can be administered, without preference for one product or formulation over another.Antiviral treatment of influenza with any licensed, recommended, age-appropriate influenza antiviral medication is recommended for children with suspected or confirmed influenza who are hospitalized, have severe or progressive disease, or have underlying conditions that increase their risk of complications of influenza. […] Antiviral treatment may be considered for any previously healthy, symptomatic outpatient not at high risk for influenza complications in whom an influenza diagnosis is confirmed or suspected, if treatment can be initiated within 48 hours of illness onset, and for children whose siblings or household contacts either are younger than 6 months or have a high-risk condition that predisposes them to complications of influenza. | 2020-09-09 |
| 32901209 | This is a case report of a 55-year-old male, with COVID-19 pneumonia who has received convalescent plasma as part of a treatment plan which showed significant radiological and clinical improvement post-treatment. | 2020-09-09 |
| 32901214 | Currently, no specific drugs, treatment or vaccines are available. | 2020-09-09 |
| 32901220 | Considering the possibility of a systemic inflammatory response in the setting of post-chemotherapy immune reconstitution, we avoided aggressive fluid administration and initiated treatment with methylprednisolone and hydroxychloroquine, resulting in rapid clearance of pulmonary infiltrates and creatinine kinase. […] Complete resolution after corticosteroid treatment may provide clinicians with a viable treatment option in similar situations and adds to the growing body of evidence pointing to dysregulated immune response as a major contributing factor to disease severity. | 2020-09-09 |
| 32901413 | There is no specific drug for this disease and treatment methods are limited. | 2020-09-09 |
| 32901560 | Conclusions The coronavirus disease 2019 outbreak induced a reduction of hospital access for STEMI with an increase in treatment delay, longer hospitalization, higher levels of cardiac biomarkers, and worse left ventricular function. | 2020-09-09 |
| 32901580 | Neuropsychologists need to understand the potential cognitive and psychological sequelae of COVID-19 and the impact of the interventions (e.g., ICU, ventilation) that have been used in treating patients with severe forms of the illness.Method: We briefly review the literature regarding the neurological and neuropsychological effects of similar coronaviruses, the limited information that has been published to date on COVID-19, and the literature regarding the long-term cognitive and psychological effects of undergoing treatment in the intensive care unit (ICU). | 2020-09-09 |
| 32901615 | It is estimated that almost 20% of patients with COVID-19 have significant coagulation disorders, and about a quarter of those hospitalized in intensive care units are prone to develop thrombosis events under prophylactic anticoagulant treatment. […] Age, pre-existing diseases and associated risk factors, together with careful monitoring of clinical evolution and laboratory parameters allow the choice of the best personalized prophylactic or curative anticoagulant treatment. | 2020-09-09 |
| 32901729 | The aim of the present infodemiological study was to evaluate whether the COVID-19 outbreak has influenced the volume of content related to the dental treatment needs of Brazilian Twitter users to summarize the trends, and to identify the perceptions of the treatment needed. […] Descriptive analysis was performed to provide summary statistics of the frequencies of tweets related to different dental treatment needs and also the differences in volume content between the years 2019 and 2020. […] Those tweets posted by non-Brazilian users, duplicates, and those unrelated to dental treatment needs were removed and, therefore 1,197 tweets from 2020 and 719 tweets from 2019 were selected. […] Content volume related to dental treatment needs greatly increased during the COVID-19 outbreak. […] Findings from the word cloud and content analysis suggest that dental pain, related or not to the third molar, and problems with orthodontic appliances were the topics most commonly related to dental treatment needs discussed during the COVID-19 outbreak, mainly conveying anxiety and distress. […] The volume of tweets related to dental treatment needs posted by Brazilian users increased during the COVID-19 outbreak and self-reported pain and urgencies were the most popular topics. | 2020-09-09 |
| 32901936 | Pathways of the viral entry into cells are interesting subjects for targeted therapy of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). […] Combinations of the following search terms were used: SARS-CoV-2, in vitro, in vivo, preclinical, targeted therapy, and cell entry. […] Targeted therapy strategies against SARS-CoV-2 cell entry mechanisms fall into four main categories: strategies targeting virus receptors on the host, strategies neutralizing SARS-CoV-2 spike protein, strategies targeting virus fusion to host cells, and strategies targeting endosomal and non-endosomal dependent pathways of virus entry. | 2020-09-09 |
| 32901940 | Until a vaccine is developed, however, effective treatment is needed to combat this virus, which is resistant to all conventional antiviral drugs. | 2020-09-09 |
| 32902023 | Our calculations suggest a wide range of contexts where the benefits of treatment to prevent progression to severe visual impairment or blindness are greater than the expected harms to the patient and immediate health care team due to COVID-19. […] For example, with appropriate protective equipment the benefits of treatment outweigh harms when the chance of progression to severe visual impairment is >0.044% for all scenarios where COVID-19 prevalence was 1/1000, even when the attack rate in the clinical setting is very high (5-43%). | 2020-09-09 |
| 32902028 | This study aimed to examine the association between the use of immunosuppressant medication and outcomes of patients hospitalized with COVID-19. | 2020-09-09 |
| 32902348 | We also discuss intervention approaches and opportunities that respond at the intersection of HIV and COVID-19 prevention and treatment. […] Given the current COVID-19 pandemic, which is disproportionately impacting individuals living with HIV and other comorbidities, the elderly, and under-resourced communities with a ferocity not seen in other communities, intervention approaches that respond at the intersection of HIV and COVID-19 prevention and treatment are also urgently needed. | 2020-09-09 |
| 32902367 | The authors carried out an extensive and comprehensive literature review on SARS-CoV-2 infection, the clinical, pathological, and radiological presentation as well as the current treatment strategies. […] The new treatment strategies are updated, and the analysis of the physiopathology is included in this review. | 2020-09-09 |
| 32902712 | Interventions included mind-body group therapy sessions in fitness, meditation, yoga, dance, tai chi, and music delivered using Zoom video conferencing. | 2020-09-09 |
| 32902818 | This offers hope for a new host-directed therapeutic approach that could (i) improve outcomes following exposure or shorten treatment regimens; (ii) reduce the chronic pathology associated with the infectious disease and subsequent comorbidity, frailty, and disability; and (iii) promote development of immunological memory that protects against relapse or improves response to vaccination. | 2020-09-09 |
| 32902940 | To date, there is no valid medication or vaccination. […] Remdesivir is an antiviral medication targeting ribonucleic acid (RNA) synthesis that has clinical improvement in the treatment of SARS-CoV-2. | 2020-09-09 |
| 32903031 | The revelation of AT2 heterogeneity has brought new insights into the role of AT2 cells in various lung disease settings and potentiates the finding of more therapeutics targets. | 2020-09-09 |
| 32903195 | Providers rated their satisfaction and responded to open-ended questions assessing challenges, strategies used to address challenges, the diagnostic process, treatment, and the patient-provider relationship. | 2020-09-09 |
| 32903199 | As COVID-19 has proven to be a moving target as far as its management is concerned, we will use current definitions according to the Ministry of Health (MOH) guidelines for diagnosis, treatment, and recovery. | 2020-09-09 |
| 32903208 | Many people have suffered from symptoms like COVID-19 during this pandemic, and some people have cured without taking any treatment or taking minor pharmacological and non-pharmacological treatments. | 2020-09-09 |
| 32903226 | There has also been the development of prototypes of locally-manufactured mechanical ventilators to meet local need at intensive care units. | 2020-09-09 |
| 32903227 | Although no antiviral drug was specifically designed for the treatment of diarrhea, several molecules could have beneficial effects by reducing viral replication. […] In this letter, we discussed the Levamisole, which is an anthelmintic agent with immunomodulatory effects, could be used effectively both for antiviral therapy and especially in COVID-19 patients with diarrhea. | 2020-09-09 |
| 32903258 | Among non-ICU patients hospitalized with COVID-19 pneumonia complicated by AHRF, treatment with corticosteroid was associated with a significantly lower risk of the primary composite outcome of ICU transfer, intubation, or in-hospital death, composite of intubation or death and individual components of the primary outcome. | 2020-09-09 |
| 32903324 | Being of Asian ethnicity [3.73 (1.28-10.91)], receiving palliative treatment [5.74 (1.15-28.79)], having an initial cancer diagnosis >24 months before [2.14 (1.04-4.44)], dyspnea [4.94 (1.99-12.25)], and increased CRP levels [10.35 (1.05-52.21)] were positively associated with COVID-19 death. […] Asian ethnicity and palliative treatment were also associated with COVID-19 death in cancer patients. | 2020-09-09 |
| 32903363 | Specific data for corticosteroid treatment were further analyzed. […] Out of the 450 patients, 126 (28.0%) received corticosteroid treatment. […] In the 126 patients treated with corticosteroids, the median daily dose of corticosteroid therapy was 56.6 [interquartile range (IQR): 40.0-78.4] mg and median corticosteroid therapy duration was 5.0 (IQR: 3.0-7.0) days. […] Among nonsevere cases, patients treated with corticosteroids were significantly older in comparison with patients who did not receive corticosteroid treatment (p<0.01); the proportion of patients receiving antibiotic therapy in the corticosteroid group was significantly higher than that in the noncorticosteroid group (p<0.001); hospitalization length and duration of viral shedding were significantly longer in patients in the corticosteroid group than in the noncorticosteroid group after adjusting for age, sex, and comorbidities (p<0.05). […] In severe cases, patients treated with corticosteroids were significantly older and comorbidities at admission were significantly more common in patients receiving corticosteroid treatment (p<0.05); the proportion of patients receiving antibiotic therapy in the corticosteroid group was significantly higher than that in the noncorticosteroid group (p<0.001); no significant difference in hospitalization length or viral shedding duration was found between two groups after adjusting for age, sex, and comorbidities (p>0.05). | 2020-09-09 |
| 32903476 | Furthermore, the myriad of drugs prescribed for these comorbidities can also influence the progression of COVID-19 and limit additional treatment options available for COVID-19. […] Moreover, we discuss the long-term challenges associated with the use of both novel and repurposed therapies for the treatment of COVID-19 in patients with pre-existing comorbidities. | 2020-09-09 |
| 32903552 | Treatment by hydroxychloroquine (HCQ) medication, among others, has been proposed. […] However, prophylactic HCQ medication has been little evaluated. […] We propose to use data from patients with rheumatic diseases (RA, SLR) who have been chronically taking HCQ medication since before the COVID-19 outbreak (hereafter: HCQpa), in order to evaluate the potential of HCQ for preventing infection with SARS-CoV-2. | 2020-09-09 |
| 32903555 | In the conditions mentioned, many people are on long-term treatment with agents including hydroxychloroquine, tumor necrosis factor alpha (TNFα) inhibitor drugs, other biologic agents such as monoclonal antibodies to IL-6 and Janus kinase inhibitors including baricitinib and tofacitinib, which are used to control inflammatory responses in their respective auto-immune condition. […] In addition, it is important to understand if subjects being treated with the immunomodulatory agents described have a less severe SARS-CoV-2 infection, as they are deemed some protection from their immunomodulatory treatment, or if they develop infections similar to non-immunocompromised patients. […] There is a huge unmet clinical need to advise patients responsibly about whether they should remain on their immunomodulatory treatment or not in light of Covid-19 infection. […] In this article we will discuss potential treatment options for SARS-CoV-2 using immunomodulatory drugs and at what stage of the condition they may be beneficial. […] Viable treatment options during the global coronavirus pandemic are a much-needed and an intensely active area of research. | 2020-09-09 |
| 32903640 | Besides, the treatment regime involves drugs like losartan, ACE inhibitors, angiotensin-receptor blockers, Remdesivir, Chloroquine, Hydroxychloroquine, etc. may modulate the severity of the comorbidities. | 2020-09-09 |
| 32903810 | The patients with COVID-19-related psychotic symptoms had responded with a short-term administration of the antipsychotic medication. […] Therefore, to identify the causal relationships between COVID-19 and psychosis, the researchers should investigate the prospective study on the direct biological impacts of COVID-19 and psychosis, and the clinicians should pay attention for psychotic symptoms at the treatment center and isolation rooms in order to reduce the complication of a novel corona virus. | 2020-09-09 |
| 32904031 | Surface hyaluronic acid removal from human pulmonary microvascular endothelial cells with hyaluronidase treatment resulted in depressed nitric oxide, an instigating mechanism for platelet adhesion to the microvascular endothelium. | 2020-09-09 |
| 32904117 | Different treatment modalities, therapeutic and prophylactic agents for its therapy are underway. […] Until the proven therapy gets available, repurposing of drugs is a better way out. […] Hydroxychloroquine (HCQ) has been a potential recourse of treatment in this regard for COVID-19 management. […] The risk-benefit analysis is mandatory to address rational drug therapy even in such a global health crisis. | 2020-09-09 |
| 32904494 | Most participants (92.2%) identified elderly individuals as one of the high-risk groups for severe complications and death while 89.5% identified supportive therapy and life support as recommended management options to date. | 2020-09-09 |
| 32904548 | Owing to the widespread transmission, high population density, high testing capacity and ineffective treatment, a continuous rise in cases was observed due to the pandemic in India. | 2020-09-09 |
| 32904593 | There is no specific and effective medication for coronavirus disease 2019 (COVID-19), and avaccine is not available in recent months. […] Based on these observations, we speculate that a single dose of 300,000 IU Vit D may have a role in the prevention and treatment of COVID-19. | 2020-09-09 |
| 32904626 | Nowadays, exploring complex dynamic of epidemic models becomes a focal point for research after the outbreak of COVID-19 pandemic which has no vaccine or fully approved drug treatment up till now. | 2020-09-09 |
| 32904652 | Patients with rheumatic diseases were aware of the general clinical features, routes of transmission, and general preventive measures regarding COVID-19 and did not significantly change their treatment practices. | 2020-09-09 |
| 32904682 | In this time, this disease has no treatment and vaccination. | 2020-09-09 |
| 32904703 | CT should be integrated as a triage test in resource-constrained environments during the pandemic to assist in the optimization of PCR-tests, isolation beds and intensive care units. | 2020-09-09 |
| 32904707 | Recent evidences pointing towards mutations within the viral spike proteins of SARS-CoV-2 that are considered the cause for this rapid spread and currently around 300 clinical trials are running to find a treatment for SARS-CoV-2 infections. […] This review will provide a detailed description of the composition and replication strategy of CoVs, an overview of the therapeutics currently evaluated in clinical trials against SARS-CoV-2 and will discuss the potential of NP-based vaccines, targeted delivery of therapeutics using nanocarriers as well as using NPs to further investigate underlying biological processes in greater detail. | 2020-09-09 |
| 32904710 | As it may take years to develop a specific therapy of COVID-19, it is urgent to emphasize the repurposing of drugs used for other conditions. […] Based on the preliminary data from clinical trials and considering the NIH and FDA recommendation, remdesivir and convalescent blood products are the most promising potential for COVID-19 treatment. […] Besides, tocilizumab might be deemed as adjunctive therapy for patients with cytokine release syndrome. | 2020-09-09 |
| 32904792 | Hospitals and intensive care units are straining to provide care for a large surge of patients with coronavirus disease 19 (Covid-19). | 2020-09-09 |
| 32904846 | The lack of treatment options for COVID-19 has raised many concerns among populations worldwide, which has led to many attempts to find alternative options to prevent the transmission of the disease or to alleviate the progression of the infection, including focusing more on preventive measures (to prevent transmission to other individuals) and the use of natural products and herbal extracts to increase immunity and decrease the probability of getting infected. | 2020-09-09 |
| 32904861 | In this paper, we review some of the aspects associated with the development of antibodies against SARS-CoV-2 and their potential use for improved diagnosis and therapy. | 2020-09-09 |
| 32904886 | Dentistry uses rotary, ultrasonic, and laser-based instruments that produce water-based aerosols in the daily, routine treatment of patients. […] There are several ways to reduce or eliminate the virus: (i) cease or postpone dentistry (public and personal health risk), (ii) screen patients immediately prior to dental treatment (by appropriate testing, if any), (iii) block/remove the virus containing aerosol by engineering controls together with stringent personal protective equipment use. | 2020-09-09 |
| 32904919 | The urgency of the search and introduction into medical practice of the method for the therapy of severe forms of pneumonia COVID-19 is due to the lack of effective treatment methods that can destroy the pathogen. […] Expectations of a good clinical effect from the application of mesenchymal stem cells (MSCs) are not groundless: there is a scientific justification in using MSCs for the treatment of inflammatory diseases and of the proven mechanisms of their action. | 2020-09-09 |
| 32904924 | In the absence of a vaccine or of more appropriate treatment options, non-pharmaceutical approaches must be used to control the spread of the COVID19. | 2020-09-09 |
| 32904943 | Endovascular therapy offers a way by which peri-operative risk can be reduced for vascular patients, while also reducing the impact of acute surgery on intensive care unit capacity. | 2020-09-09 |
| 32904951 | Schools are also an essential source of nonacademic supports in the way of health and mental health services, food assistance, obesity prevention, and intervention in cases of homelessness and maltreatment. | 2020-09-09 |
| 32904956 | We will discuss the reasoning behind the type of therapy used and the various lessons learned. | 2020-09-09 |
| 32904963 | As the coronavirus pandemic evolves, our understanding of the virus continues to improve; however, there remains a host of unanswered questions about atypical presentation, management and treatment options. | 2020-09-09 |
| 32904969 | Here, we review the available evidence for prevalence and incidence of AF in patients infected with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and discuss disease management approaches and potential treatment options for COVID-19 infected AF patients. | 2020-09-09 |
| 32904987 | Baseline levels of sodium, potassium, calcium and chloride were assessed and the effects of abnormalities in these electrolytes on requirement for intensive care unit and mechanical ventilation, hospitalization duration and treatment outcome were evaluated. | 2020-09-09 |
| 32904993 | Even a search for potential cures or useful medication in the face of a public health crisis is hampered by partisanship and polarization. | 2020-09-09 |
| 32905013 | This review focuses on the description of the operational measures implemented in a breast imaging department in accordance with existing recommendations for the treatment of breast cancer during the COVID-19 pandemic to make optimal use of finite resources without interruption of essential imaging services for breast cancer patients. | 2020-09-09 |
| 32905019 | With a rate of approximately 20%, deep vein thrombosis (DVT) of the leg is one of the most common thromboembolic events in COVID-19 patients requiring intensive care treatment. […] The treatment of thromboses should be carried out according to current guidelines with therapeutic anticoagulation. | 2020-09-09 |
| 32905072 | COVID-19 patients with uncontrolled diabetes required intensive treatment as compared with controlled diabetes group in terms of insulin therapy (p = 0.0226) and non-invasive ventilation (p = 0.0292). […] Uncontrolled diabetes mellitus might be responsible for an overall higher susceptibility for COVID-19 infection and severity in terms of symptomatic presentation, inflammatory storm, rapid pulmonary invasion, requirement of more intensive treatment, and a poor outcome. | 2020-09-09 |
| 32905078 | We model the features capped by the explicit treatment of the borrowing firm’s credit risk, the optimal guaranteed rate-setting, and the coronavirus disease (COVID-19) outbreak. | 2020-09-09 |
| 32905100 | Online therapy sessions and other forms of digital mental health services (DMH) have seen a sharp spike in new users since the start of the COVID-19 pandemic. | 2020-09-09 |
| 32905136 | As a consequence, the risk associated with cancellation or delayed treatment was difficult to assess. | 2020-09-09 |
| 32905141 | Since it may affect the overall cure as well as quality of life of these patients, it is necessary to continue providing surgical treatment but with minimal additional health hazards to the patient or the health care worker. […] When compared to the data of similar period in the previous year, 60% of the workload in the cancer-related cases could be offered surgical treatment, whereas the noncancer cases operated were only 25%. | 2020-09-09 |
| 32905148 | Considering there is no proven therapy for COVID-19 infection, there is a need to propose potential treatment options. […] Therefore, we carried out an early systematic review to evaluate the efficacy of convalescent plasma (CP) therapy and its effects on COVID-19 patient outcomes. […] However, our results showed that plasma therapy produces notable improvements in patients’ clinical symptoms and radiological and biochemical parameters associated with COVID-19 infection. […] Based on the available information, it is difficult to draw a tangible conclusion about whether plasma therapy improves patient mortality. […] Until we have concrete evidence to prove otherwise, convalescent plasma therapy may be used as adjuvant therapy for treating COVID-19 infection in critically ill patients. | 2020-09-09 |
| 32905189 | The advantages of TCM in the treatment of COVID-19 include effective relief of symptoms, retarding the development from mild and moderate to severe, improvement of cure rate, reducing death rates, and promotion of rehabilitation. […] Besides, according to the different severity levels of individual cases, the National Health Commission of the People’s Republic of China issued treatment guidelines that provide corresponding prescriptions for patients. […] From the perspective of TCM, this review aims to analyze the role of a variety of TCM prescriptions in the treatment of COVID-19, focusing on the analysis of the “Three TCM prescriptions and three medicines” recommended by the Chinese authorities during the pandemic. […] We expect that this review will provide insights into the prevention and treatment of COVID-19 with TCM. | 2020-09-09 |
| 32905208 | Considering these promising experimental data, we hypothesize that PHD inhibitors could be considered as a possible new therapy against severe SARS-CoV-2 infection. | 2020-09-09 |
| 32905265 | The accuracy of device under study was compared against the gold standard patient monitoring systems used in intensive care units. | 2020-09-09 |
| 32905393 | The main protease (Mpro) of SARS-CoV-2 is a potential target for treatment of COVID-19 due to its critical role in maturation of viral proteins and subsequent viral replication. […] Conceptually and technically, targeting therapy against Mpro is similar to target therapy to treat cancer. […] Due to the conservation of structure and catalytic mechanism of coronavirus main protease, repurposition of GC376 against SARS-CoV-2 may be an effective way for the treatment of COVID-19 in humans. […] Because GC376 is already known as a broad-spectrum antiviral medication and successfully used in animal, it will be a suitable candidate for anti-COVID-19 treatment. | 2020-09-09 |
| 32905485 | Certain diagnostic criteria and online tools may help to arrive at an earlier presumptive diagnosis which, in turn, may expedite treatment and lead to better clinical outcomes. | 2020-09-09 |
| 32905504 | The crisis has also brought great challenges to the routine diagnosis and treatment of cancer patients, especially given the urgency and continuity of cancer care. […] How to preserve high-quality anti-tumor therapy for cancer patients while maintaining strict prevention and control of COVID-19 is a matter of concern. | 2020-09-09 |
| 32905551 | Background and objective Angiotensin-converting enzyme inhibitors (ACE) and angiotensin II receptor blockers (ARB) are commonly used for the treatment of patients with heart disease, hypertension (HTN), and diabetes mellitus (DM). […] Results Of the 469 patients included in the study, 91 patients (19.4%) used ACE/ARB therapy during their hospital stay and were labeled as ACE/ARB group. […] Patients in the ACE/ARB therapy group were older and had a higher incidence of HTN, coronary artery disease (CAD), congestive heart failure, DM, asthma, and chronic obstructive pulmonary disease. […] Univariate analysis by treatment group using the log-rank test produced significant results (p=0.0062), indicating a higher survival rate for the ACE/ARB group. | 2020-09-09 |
| 32905568 | Considering the cost-effectiveness of the imaging used, ultrasound is a non-ionizing, portable and bedside imaging modality with a high diagnostic impact in emergencies and intensive care units in pandemics, but it is operator dependent. […] Awareness of health care professionals in the front-line fighting COVID-19 infection in emergency rooms, clinics, and in intensive care units is important and will help rapid and targeted management decisions. | 2020-09-09 |
| 32905581 | Most patients (94.3%) were on antiretroviral therapy (ART), 88.7% had HIV virologic suppression, and 80.8% had comorbidities. | 2020-09-09 |
| 32905621 | In the alternative virtual educational approach that was created, students applied an interprofessional practice concept leading to patient treatment planning outcomes. […] An association was noted between students’ staging of risk for ROHD and their subsequent recommendations for treatment. | 2020-09-09 |
| 32905639 | We aimed to assess the 1-month outcome in ischaemic stroke patients with Covid-19 infection who received IVT alone or before thrombectomy (bridging therapy). […] Thirty patients received IVT alone and 17 received bridging therapy between 21 February 2020 and 30 April 2020 in 20 centers (n = 18, Northern Italy; n = 2, Central Italy). […] In survivors with a 1-month mRS score of 3 to 5, baseline glucose level was higher, whereas endovascular procedure time in cases of bridging therapy was longer. | 2020-09-09 |
| 32905655 | Drugs considered for treatment of COVID-19 should consider effects on organelles including mitochondria functions. | 2020-09-09 |
| 32905791 | We modeled the number of visits averted if a minimum of 15 percent or a maximum of 70 percent of medication abortion patients had a “no-test” telemedicine abortion. […] We estimate that 12,742 in-person clinic visits (50,978 clinical contacts) would be averted each month if counseling visit laws alone were repealed, and 31,132 visits (142,910 clinical contacts) would be averted if all four policies were repealed and 70 percent of medication abortion patients received no-test telemedicine abortions. | 2020-09-09 |
| 32905794 | PolyP retains its activity in a flushing solution, opening a new strategy for the prevention and treatment of SARS-CoV-2 infection in the oropharyngeal cavity. | 2020-09-09 |
| 32905833 | We analysed real-time RT-PCR tests for SARS-CoV-2 in upper respiratory specimens conducted at the Virology Laboratory of the University Hospital of Udine, Italy (which serves the whole province) from 1 March to 30 April 2020 Specimens were from positive individuals in four groups characterized by different disease severity (critically ill patients admitted to intensive care units, patients admitted to infectious disease units, symptomatic patients visiting the emergency department and not hospitalized, and asymptomatic individuals tested during contact tracing or screening activities). | 2020-09-09 |
| 32905864 | In this context, online Eye Movement Desensitization and Reprocessing (EMDR) is an emerging treatment for patients with Posttraumatic Stress Disorder (PTSD). […] Remotely delivered cognitive behavioural therapy seems the preferred PTSD-treatment in times of COVID-19. | 2020-09-09 |
| 32905939 | Coronavirus pandemic is currently a global public health emergency with no definitive treatment guidelines. […] The study population consisted of a total of 4984 patients, of which 1721 (34.5%) received hydroxychloroquine or its congeners (HCQ group) while 3091 (62.01%) received standard of care or had included antiviral medication (control group). […] The pooled estimate of successful treatment in the hydroxychloroquine group and the control group was 77.45% and 77.87% respectively, which indicated similar clinical outcomes in patients treated with hydroxychloroquine compared to the control group. | 2020-09-09 |
| 32906149 | Potential confounders for negative serological results include antiretroviral medication use and pauci-symptomatic patients. | 2020-09-09 |
| 32907357 | Based on inhibition of viral replication and limited reports on clinical efficacy, hydroxychloroquine is being considered as prophylaxis and treatment of coronavirus disease-19 (COVID-19). […] Although hydroxychloroquine is generally considered safe during pregnancy based on studies in patients with systemic lupus erythematosus and other rheumatic conditions, there may still be reluctance to institute this antimalarial during pregnancy for the sole purpose of antiviral therapy. | 2020-09-10 |
| 32907358 | Efforts have focused on testing antiviral drugs and vaccines, but there is currently no treatment specifically approved. […] Currently, the Chinese National Health Commission recommended a TCM prescription of Qing-Fei-Pai-Du-Tang (QFPDT) in the latest version of the “Diagnosis and Treatment guidelines of COVID-19” which has been reported to provide reliable effects for COVID-19. […] While doubts about TCM still exist today, this review paper will describe the rationalities that QFPDT is likely to bring a safe and effective treatment of COVID-19. | 2020-09-10 |
| 32907362 | Critical care medicine is a medical specialty engaging the diagnosis and treatment of critically ill patients who have or are likely to have life-threatening organ failure. […] Sepsis, a life-threatening condition that arises when the body responds to infection, is currently the major cause of death in intensive care units (ICU). […] Although progress has been made in understanding the pathophysiology of sepsis, many drawbacks in sepsis treatment remains unresolved. […] For example, antimicrobial resistance, controversial of glucocorticoids use, prolonged duration of ICU care and the subsequent high cost of the treatment. […] In this paper, we will provide an overview of the current status of Chinese herbal formulations, single herbs, and isolated compounds, as an add-on therapy to the standard Western treatment in the sepsis management. […] With the current trajectory of worldwide pandemic eruption of newly identified Coronavirus Disease-2019 (COVID-19), the adjuvant TCM therapy can be used in the ICU to treat critically ill patients infected with the novel coronavirus. | 2020-09-10 |
| 32907371 | Understanding the demographic, clinical, and laboratory characteristics of these patients is important toward developing successful treatment strategies. | 2020-09-10 |
| 32907512 | Consequently, advancing models for the antiviral activity of therapeutic agents is a necessary component of the fast development of treatment for the virus. | 2020-09-10 |
| 32907540 | We reported a case of 66-year-old man infected with COVID-19, presenting with fever, cough and myalgia; The patient received supportive and empirical treatment including antiviral treatment, anti-inflammatory treatment, oxygen supply and inhalation therapy; The symptoms, CT images, laboratory results got improved after the treatments, and a throat swab was negative for COVID-19 PCR test; However, on the hospital day 30, the patient presented with a sudden chest pain and dyspnea. […] This case highlights the importance for clinicians to pay attention to the appearance of spontaneous pneumothorax, especially patients with severe pulmonary damage for a long course, as well as the need for early image diagnose CT and effective treatment once pneumothorax occurs. | 2020-09-10 |
| 32907595 | Mental status and brain imaging findings gradually worsened despite antiviral therapy and intravenous dexamethasone. | 2020-09-10 |
| 32907596 | Currently, no specific prophylaxis or treatment is available for CoV infections. […] Furthermore, we exposed cells to the extract after infection to further evaluate its potential as a prophylaxis and treatment against coronaviruses. […] Pre-treatment of cell lines, however, did not inhibit infection with HCoV-229E and post-infection treatment had only a marginal effect on virus propagation at 50 μg/ml. […] Finally, the causative agent of COVID-19, SARS-CoV-2 was also inactivated upon treatment with 50μg/ml Echinaforce®. […] Therefore we hypothesize that Echinacea purpurea preparations, such as Echinaforce®, could be effective as prophylactic treatment for all CoVs due to their structural similarities. | 2020-09-10 |
| 32907635 | Patients aged 50 years or older with a positive test for SARS-CoV2 in the past 5 days and eligible for ambulatory treatment. […] Any acute or chronic condition posing an indication for anticoagulant treatment, e.g. atrial fibrillation, prior venous thromboembolism (VTE), acute confirmed symptomatic VTE, acute coronary syndrome. […] Contraindications to enoxaparin therapy, including prior heparin-induced thrombocytopenia and known hypersensitivity. […] Current use of dual antiplatelet therapy. […] Non-compliance or inability to adhere to treatment or lack of a family environment or support system for home treatment. | 2020-09-10 |
| 32907637 | The purpose of this review is primarily reviewing the COVID-19 disease, including pathogen, clinical features, diagnosis, and treatment with particular attention to cardiovascular involvement based on the current evidence. […] At the moment, there is no specific treatment for COVID-19, but multiple randomized controlled trials (RCT) are being conducted. | 2020-09-10 |
| 32907638 | In addition, as an exploratory objective, to compare the baseline clinical and biological parameters, including serum IL-6 levels, of the intervention population against controls of the same pandemic outbreak (using a propensity score) to search for markers that identify the best candidates for the treatment with subcutaneous IL-6R inhibitors and to attempt an approximation in the temporal frame of the “window of opportunity” TRIAL DESIGN: SARCOVID is an investigator-initiated single center randomised proof of concept study. […] Immunosuppressive anti-rejection therapy. j. […] Previous treatment with tocilizumab or sarilumab. l. […] The intervention group, sarilumab plus standard of care, will receive 400 mg single dose treatment with Sarilumab (Kevzara), 2 subcutaneous injections 200mg each in a pre-filled syringe. […] Treatment with drugs or procedures in routine clinical practice that the clinician responsible for the patient deems necessary is allowed. […] Number of deaths at the end of study RANDOMISATION: Randomisation to treatment arms sarilumab plus standard of care or standard of care in a 2:1 ratio will be performed by the Clinical Research and Clinical Trials Unit (CRCTU) at the Hospital using a table of random numbers, an internet-based randomisation tool. […] After checking that all inclusion criteria are met and none of the exclusion criteria, CRCTU will communicate the recruiting investigator the assigned treatment. | 2020-09-10 |
| 32907660 | Country region, performance of social distancing, dental specialty, the believe on personal protective equipment and biosafety preventive measures influenced the likelihood of dentists to perform dental treatment, either elective or urgent, during the COVID-19 pandemic. […] The need of extra preventive barriers for dental treatment may bring an extra financial stress in the Brazilian public primary and secondary healthcare system, as well as in the patient-dentist relationship, which may have to be reframed. […] Internationally accepted public guidelines policies regarding dental treatment safety, as well as the technological development of preventive tools, are needed to deal with the challenges brought by COVID-19. | 2020-09-10 |
| 32907668 | Health system preparedness for COVID-19 includes projecting the number and timing of cases requiring various types of treatment. | 2020-09-10 |
| 32907791 | A subgroup of them also participated in a self-administered, internet-based survey evaluating demographics; LT data and immunosuppressive therapy; comorbidities; attitudes towards COVID-19 infection; their perceptions of the need for health care, and their approach to telemedicine. | 2020-09-10 |
| 32907861 | These hyperstable minibinders provide starting points for SARS-CoV-2 therapeutics. | 2020-09-10 |
| 32907890 | By multivariable analysis, the only two significant predictors of CTPA-confirmed PE were D-dimer level and the lack of any anticoagulant therapy (OR 4.0 (95% CI 2.4-6.7) per additional quartile and OR 4.5 (95% CI 1.1-7.4), respectively). […] Elevated D-dimers (>2590 ng·mL-1) and absence of anticoagulant therapy predict PE in hospitalised COVID-19 patients with clinical signs of severity. | 2020-09-10 |
| 32907891 | Pneumothorax does not seem to be an independent marker of poor prognosis and we encourage active treatment to be continued where clinically possible. | 2020-09-10 |
| 32908046 | Furthermore, the median duration from oxygen therapy initiation to death or intubation was significantly shorter in the patients with hematological disease (5 days [range, 1-17 days] vs. 10 days [1-24 days], respectively; P<0.05). | 2020-09-10 |
| 32908073 | COVID-19 is highly contagious, and therapy against the virus remains premature and largely unknown, which makes the management of AF patients during the pandemic particularly challenging. | 2020-09-10 |
| 32908333 | Trauma-focused care (including telemental health) refers to evidence-based treatment models that directly facilitate recovery from trauma-related conditions like posttraumatic stress disorder. […] Despite the widespread availability of trauma-focused treatment in VHA, not all veterans chose to engage in it. | 2020-09-10 |
| 32908341 | Challenges arose in infection control, communication, mechanical ventilation using anesthesia machines, providing renal replacement therapy, and maintaining patient privacy in an open unit. | 2020-09-10 |
| 32908530 | Early and accurate detection of the viral presence in patient sample is crucial for appropriate treatment, control, and prevention of epidemics. | 2020-09-10 |
| 32908675 | Differential treatment of individuals based on COVID-19 antibody test results can be justified through the proportionality principle, which offers a sound dividing line between a reasonable and legitimate response and an unjust and discriminatory response. | 2020-09-10 |
| 32908681 | Seven single cases and one case series, reporting a total of 10 patients affected by retinal changes secondary to long-term ritonavir treatment, were included in the review. | 2020-09-10 |
| 32908697 | Lower levels of depression were seen in those using positive coping strategies and showing high levels of personal and treatment control. | 2020-09-10 |
| 32908705 | The combination of physical rehabilitation and medical treatment would result in improved treatment outcomes, faster recovery, and shorter hospital stay. | 2020-09-10 |
| 32908736 | Although a variety of existing drugs are being tested for patients with coronavirus disease 2019 (COVID-19), no efficacious treatment has been found so far, particularly for severe cases. | 2020-09-10 |
| 32908840 | Symptomatic treatment with oxygen supplementation and pulmonary physical therapy was initiated, and hydroxyurea was discontinued. […] Whether patients with severe COVID-19 benefit from immunosuppressive therapy should be further evaluated. | 2020-09-10 |
| 32908842 | Hydroxychloroquine has been used worldwide as a first-line treatment for patients hospitalized with COVID-19. | 2020-09-10 |
| 32909049 | POCUS reduces exposure to radiation, therapy delays, and minimizes transport of high-risk patients. | 2020-09-10 |
| 32909234 | EPN requires early diagnosis and treatment due to the possible life-threatening septic complications. […] Our patient first noticed abdominal pain 3 weeks prior to hospital presentation; however, he avoided getting treatment due to a fear of contracting severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). | 2020-09-10 |
| 32909322 | A decrease in the number of outpatients for infertility treatment was also observed. | 2020-09-10 |
| 32909528 | These findings showed that there were potential drugs that inhibit SARS-Cov-2’s 3CLpro in the current clinical drug library, and these drugs can be further tested or chemically modified for the treatment of COVID-19. | 2020-09-10 |
| 32909541 | She presented with COVID-19 mediated hypoxic respiratory failure complicated by AKI requiring provisional renal replacement therapy with recovery of kidney function with a new baseline of creatinine of 1.6 - 1.8 mg/dL with GFR of 31 mL/min/1.73m2. | 2020-09-10 |
| 32909713 | We report the successful management of a case of refractory hypoxia due to acutely acquired methemoglobinemia in a patient undergoing treatment for coronavirus disease 2019 (COVID-19) pneumonia. | 2020-09-10 |
| 32909725 | We report for the first time therapy-resistant hypernatremia (plasma sodium concentration ≥150 mmol per liter) developing in 6 of 12 critically ill coronavirus disease 2019 (COVID-19) patients age 57-84 years requiring mechanical ventilation. | 2020-09-10 |
| 32909838 | A better and more close attention to the potential DDIs among statins and other therapeutic options will help physicians in selecting the more effective and less harmful treatment for their patients. | 2020-09-10 |
| 32909852 | All relapses were due to non-adherence to therapy. | 2020-09-10 |
| 32909983 | Our members urge that treatment for acute and severe conditions due to substance use should be considered as essential services in times of humanitarian crises like COVID-19. | 2020-09-10 |
| 32910175 | Convalescent plasma therapy is a leading treatment for conferring temporary immunity to COVID-19 susceptible individuals or for use as post-exposure prophylaxis. | 2020-09-10 |
| 32910179 | To determine whether a therapy that increases peripheral blood leukocyte and lymphocyte cell counts leads to clinical improvement in patients with COVID-19. […] In preliminary findings from a randomized clinical trial, rhG-CSF treatment for patients with COVID-19 with lymphopenia but no comorbidities did not accelerate clinical improvement, but the number of patients developing critical illness or dying may have been reduced. | 2020-09-10 |
| 32910251 | It is difficult to diagnose, especially in compromised COVID-19 patients but should be kept in mind as early diagnosis and treatment are crucial. | 2020-09-10 |
| 32910321 | Among the drawbacks of immunosuppressive therapy, the risk of reactivation of latent infections, including parasitic infestations, is to be considered. […] We report the first case of S. stercoralis infection following an 11-day treatment with high-dose steroids and Tocilizumab for severe COVID-19. […] Clinicians should be aware of the risk of strongyloidiasis as a complication of the treatment for severe COVID-19. | 2020-09-10 |
| 32910408 | Pulmonary embolism was diagnosed in 92% of patients; 5 patients required intensive care and 3 underwent thrombolysis. 27 patients received initial treatment with unfractionated heparin/low molecular weight heparin (LMWH) while 10 were treated with direct anticoagulants (DOACs). […] Our results suggest that direct anticoagulants could be a safe and effective treatment option in selected COVID-19 positive patients who have suffered venous thromboembolism. | 2020-09-10 |
| 32910456 | The severity of the respiratory syndrome at presentation and active hematologic treatment were independently associated with a worse prognosis. […] The worst prognosis was demonstrated among patients on active hematologic treatment and those with more severe respiratory syndrome at COVID-19 presentation. […] Coronavirus disease 2019 (COVID-19) infection occurs across all different types of hematologic disease; however, the risk of acquiring it is lower for patients with chronic myeloproliferative neoplasms, including chronic myeloid leukemia, and higher for patients with immune-mediated anemia on immunosuppressive treatment. […] Variables independently associated with a worse prognosis are the severity of the respiratory syndrome at presentation and any type of active hematologic treatment. | 2020-09-10 |
| 32910692 | To review the literature on the definition of aerosol-generating procedures (AGPs), identify high-risk AGPs, guidelines to use personal protective equipment (PPE) and review evidence to see if electroconvulsive therapy (ECT) is a high-risk AGP requiring the use of PPE. | 2020-09-10 |
| 32910698 | There was no improvement after antibiotic treatment. | 2020-09-10 |
| 32910699 | Low dose radiation therapy (LDRT) has been evaluated as a potential therapeutic modality for COVID-19 pneumonia. […] However, due to heterogeneity in disease manifestation and inter-individual variations, effective planning for LDRT is limited for this large-scale event. 2-deoxy-D-glucose (2-DG) has emerged as a polypharmacological agent for COVID-19 treatment due to its effects on the glycolytic pathway, anti-inflammatory action, and interaction with viral proteins. […] We suggest that 2-DG will be a potential adjuvant to enhance the efficacy of LDRT in the treatment of COVID-19 pneumonia. | 2020-09-10 |
| 32910704 | Adipose-derived stromal cells (ADSCs) can be an important alternative in COVID-19 prevention, treatment, and subsequent sequelae repair. | 2020-09-10 |
| 32910806 | The probability of a VN titer ≥160, the FDA-recommended level for convalescent plasma used for COVID-19 treatment, was ≥80% when anti-RBD or anti-ECD titers were ≥1:1350. | 2020-09-10 |
| 32910830 | This study aimed to investigate whether specific medications used in the treatment chronic diseases affected either the development and/ or severity of coronavirus disease 2019 (COVID-19) in a cohort of 610 COVID-19 cases and 48,667 population-based controls from Zhejiang, China. […] Drugs used in the treatment of hypertension and diabetes influence the risk of development of COVID-19, but, not its severity. | 2020-09-10 |
| 32910933 | Chloroquine (CQ) and Hydroxychloroquine (HCQ) have been commonly used for the treatment and prevention of malaria, and the treatment of autoimmune diseases for several decades. | 2020-09-10 |
| 32910955 | So far, neither effective vaccines nor approved antiviral therapeutics are currently available for the treatment of FIPV infection. | 2020-09-10 |
| 32911000 | Since the body of evidence addressing the coagulation derangements caused by Coronavirus disease (COVID-19) has been constantly growing, we investigated whether pre-hospitalization oral anticoagulation (OAC) or in-hospital heparin treatment could have a protective role among COVID-19 patients. […] Baseline demographic, clinical, laboratory, and radiological characteristics, as well as in-hospital treatment and outcomes were evaluated. […] In our cohort, OACs appeared to be ineffective in reducing mortality rate, while heparin resulted to be a useful treatment when lung disease was sufficiently severe, potentially suggesting a crucial role of microthrombosis in severe COVID-19. | 2020-09-10 |
| 32911064 | The ongoing crisis due to the global pandemic caused by a highly contagious coronavirus (Coronavirus disease - 2019; COVID-19) and the lack of either proven effective therapy or a vaccine has made diagnostic a valuable tool in disease tracking and prevention. | 2020-09-10 |
| 32911080 | To describe the fraction of asymptomatic health-care workers (HCWs) in two designated hospitals for coronavirus disease 2019 (COVID-19) treatment in Wuhan and explore the factors associated with asymptomatic severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. | 2020-09-10 |
| 32911110 | The patients were separated into two groups for statistical analysis: those receiving low-molecular-weight heparin prophylaxis and those receiving intermediate or complete anticoagulation treatment. […] The patients receiving prophylactic anticoagulation treatment had a greater risk of DVT (16.21%; 95% confidence interval, 0.04-0.28; P = .056) compared with those receiving intermediate or complete anticoagulation treatment. […] We also found a protective factor for DVT in the intermediate or complete anticoagulation treatment group (odds ratio, 0.19; 95% confidence interval, 0.08-0.46; P < .05). | 2020-09-10 |
| 32911123 | In the absence of a vaccine or efficient treatment, cost-effective epidemiological surveillance strategies are urgently needed. | 2020-09-10 |
| 32911141 | This is the first study that investigates the potential health risks of SARS-CoV-2 in sewage to wastewater treatment plant (WWTP) workers. | 2020-09-10 |
| 32911282 | We asked questions about COVID-19 risk in rheumatic patients, as well as their medication management during the pandemic. […] A third of respondents indicated that at least 10% of their patients had self-discontinued or reduced at least one immunosuppressive medication to mitigate their risk of COVID-19. | 2020-09-10 |
| 32911619 | Patients treated with lopinavir + ritonavir or antiplatelet therapy during admission had lower RPCP-FI and RPCP-PD. | 2020-09-11 |
| 32911691 | Immunological therapies, including vaccines and humanized monoclonal antibodies, have been proposed as major strategies for prevention and treatment of the disease. | 2020-09-11 |
| 32911778 | First, a non-systematic review of the current state of knowledge regarding the impact of an optimal nutritional status of these nutrients on the proper functioning of the immune system as well as their potential role in COVID-19 prevention/treatment was carried out by searching for available scientific evidence in PubMed and LitCovid databases. | 2020-09-11 |
| 32911986 | Although the value and effectiveness of extracorporeal membrane oxygenation (ECMO) in severe respiratory illness from COVID-19 remains unclear at this time, there is emerging evidence suggesting that it could be utilized as an ultimate treatment in appropriately selected patients not responding to conventional care. | 2020-09-11 |
| 32912236 | Fast point-of-care (POC) diagnostics represent an unmet medical need and include applications such as lateral flow assays (LFAs) for the diagnosis of sepsis and consequences of cytokine storms and for the treatment of COVID-19 and other systemic, inflammatory events not caused by infection. | 2020-09-11 |
| 32912357 | This created a need to modify regular methods of treatment at a rapid pace, to avoid cessation of clinical intervention and prevent potential regression in mental health. […] Eighteen children with moderate-severe mental health disorders and their parents were attending weekly group cognitive behaviour therapy (CBT) based sessions (‘The Secret Agent Society’ (SAS) programme) when the Irish Department of Health suspended face-to-face intervention. […] Whilst internet technology has emerged as a promising solution to shortfalls in therapy services, in-depth exploration is needed to confirm the efficacy of telehealth for children attending CAMHS. | 2020-09-11 |
| 32912359 | Using the paradigm of space, staff, and stuff, an outdoor treatment area was designed and placed into operation. […] The patient volume in the treatment tents quickly grew with a one-day max volume of 88 patients. | 2020-09-11 |
| 32912389 | A composite of poor outcome, mortality, severe COVID-19, the need for treatment in an intensive care unit (ICU) and disease progression were the outcomes of interest.RESULTS: Data on 4603 patients were pooled from 21 studies. | 2020-09-11 |
| 32912400 | “The battle field of Chinese doctor for anti-epidemic” was formed in fighting against severe acute respiratory syndrome (SARS) epidemics in China, and from the battle, valuable experiences of using TCM for prevention and treatment had been obtained. […] And a whole process of TCM pattern or a model was organized, including early prevention in communities, cluster intervention in isolated places, comprehensive intervention in mobile cabin hospitals, centralized treatment in designated hospitals and rehabilitation support in rehabilitation posts. […] Thus, the innovation of whole process of TCM intervention was involved in the “trench warfare” strategy and platform system for prevention and treatment of new infectious COVID-19 epidemics. […] At different stages or conditions, different TCMs were used to play advantageous roles to solve various problems and elevate the effects of prevention and treatment of the disease. […] The construction of TCM mobile cabin hospitals was an innovation of organization form that might offset the constraints in technology and scale of simple community isolation or simple hospital treatment, exploring a new way for TCM to cope with public health emergencies. | 2020-09-11 |
| 32912403 | The scores of fever, cough, chest tightness, shortness of breath, and fatigue decreased with the treatment time, and the scores of 7 days and 14 days after treatment were significantly lower than those before treatment [fever (points): 0 (0, 0), 0 (0, 0) vs. 1 (0, 1); cough (points): 1 (0, 1), 0 (0, 1) vs. 1 (0, 2); chest tightness (points): 0 (0, 0), 0 (0, 0) vs. 0 (0, 1); shortness of breath (points): 0 (0, 0), 0 (0, 0) vs. 0 (0, 1); fatigue (points): 0 (0, 1), 0 (0, 1) vs. 1 (0, 1); all P < 0.05]. […] The treatment with integrated traditional Chinese and Western medicine has good curative effect on common type of COVID-19 in 7 designated hospitals of Henan Province. | 2020-09-11 |
| 32912404 | If there is no alternative drug, liver protection treatment should be considered appropriately. | 2020-09-11 |
| 32912527 | The consequences of lack of diagnosis and treatment of a large proportion of acute stroke patients are likely severe and lasting. | 2020-09-11 |
| 32912716 | After several weeks of specific symptomatic treatment, the patient had a favorable outcome. […] In conclusion, despite being a rare complication, we think it is important to consider the possibility of diffuse involvement of the peripheral nervous system in patients with COVID-19 to adjust clinical monitoring and treatment in these cases. | 2020-09-11 |
| 32912808 | The questionnaire was divided into 6 parts consisting of 39 questions for a total possible score of 0 to 39; to assess the participants’ general knowledge [10 items]; symptoms knowledge [2 items]; transmission knowledge [6 items]; preventive knowledge [4 items]; treatment knowledge [6 items], and public knowledge of governmental and international efforts [10 items]. […] 80.5% of the participants believed that there is no effective treatment or vaccine available for the coronavirus. | 2020-09-11 |
| 32912875 | A total of 641 patients presented to our institution between March 3, 2020, and May 6, 2020, for treatment of coronavirus disease 2019, of whom, 150 underwent CT and/or MR imaging of the brain. | 2020-09-11 |
| 32912958 | Study responses related to impacts on key elements of healthcare, as well as practical, psychological and social consequences related to the COVID-19 pandemic and social distancing measures. 45% reported disruptions to care, including cancellations of appointments, investigations, pulmonary rehabilitation, treatment and monitoring. | 2020-09-11 |
| 32912961 | Tocilizumab (TCZ) inhibits ligand binding to the IL-6 receptor and may be a potential treatment for the hyperinflammation symptoms of COVID-19. […] In each group, 10 patients no longer required oxygen therapy. […] Selecting the best candidates and the best timing for TCZ therapy needs to be determined in randomised clinical trials. | 2020-09-11 |
| 32912996 | To evaluate the quality of information regarding the prevention and treatment of COVID-19 available to the general public from all countries. […] All websites written in the English language, and provides information on prevention or treatment of COVID-19 intended for the general public were considered eligible. […] Majority of websites discuss prevention alone despite popular search trends of COVID-19 treatment. […] Websites discussing both prevention and treatment (n=73, 23%) score significantly higher across all tools (p<0.001). | 2020-09-11 |
| 32913008 | We and others propose vimentin as a possible cellular target for the treatment of COVID-19. […] Consequently, we speculate here that drugs which decrease the expression of vimentin can be used for the treatment of patients with COVID-19 and advise that several Food and Drug Administration-approved drugs be immediately tested in clinical trials against SARS-CoV-2, thus broadening therapeutic options for this type of viral infection. | 2020-09-11 |
| 32913009 | Few COVID-19 therapeutics are available, and the basis for severe infections is poorly understood. […] However, recent studies highlight the potential for IFNs to enhance expression of host angiotensin-converting enzyme 2 (ACE2), suggesting that IFN therapy or natural coinfections could exacerbate COVID-19 by upregulating this critical virus entry receptor. […] These insights should aid in evaluating the benefits of specific IFNs, particularly IFN-λ, as repurposed therapeutics.IMPORTANCE Repurposing existing, clinically approved, antiviral drugs as COVID-19 therapeutics is a rapid way to help combat the SARS-CoV-2 pandemic. | 2020-09-11 |
| 32913034 | The present paper is based on an extensive survey among 21 406 adult participants of various sections of Indian society with different age groups between 18 and 80 years to introspect the level of public awareness with respect to cause, spread, prevention and treatment of disease caused by spread of COVID-19 viral outbreak, which will be automatically reflected in the societal behavioural response of rigorous precautionary measures. | 2020-09-11 |
| 32913137 | Heparin and heparan sulfate antagonize the binding of these pathogens to HSPGs and stop their cellular internalization, but the anticoagulant effect of these agents has been limiting their use in the treatment of viral infections. […] Furthermore, we will discuss a variant of these peptides that is in the clinic and can be considered as a novel therapy in coronavirus disease 2019 (COVID-19) infection. […] SIGNIFICANCE STATEMENT: The need to discover treatment modalities for COVID-19 is a necessity, and therapeutic interventions such as heparin-binding peptides (HBPs), which are used for other cases, can be beneficial based on their mechanisms of actions. | 2020-09-11 |
| 32913297 | Many developed countries have implemented widespread testing and have rapidly mobilized research programmes to develop vaccines and therapeutics. […] This Review discusses global efforts to develop diagnostics, therapeutics and vaccines, with these considerations in mind. | 2020-09-11 |
| 32913304 | Furthermore, treatment with vitamin C blocked IL7-induced ACE2 expression. | 2020-09-11 |
| 32913364 | There is an urgent need for effective treatment and preventive vaccine to contain this devastating global pandemic, which requires a comprehensive understanding of humoral responses specific to SARS-CoV-2 during the disease progression and convalescent phase of COVID-19 patients. | 2020-09-11 |
| 32913581 | There are no approved target therapeutics against SARS-CoV-2 or other beta-CoVs. | 2020-09-11 |
| 32913696 | Findings related to pathophysiologic patterns and treatment strategies are also described. […] In a separate study, vasodilatation with calcium channel blocker (CCB) therapy has been associated with improved mortality in COVID-19 and potential pathophysiologic mechanisms were previously presented. […] It also advances the basis for use of vasodilator therapy as part of treatment regimens in COVID-19. | 2020-09-11 |
| 32913846 | Concurrently, cancer treatment protocols must be adapted to prioritise according to oncologic response and prognosis. | 2020-09-11 |
| 32913866 | Conservative treatment was administrated. | 2020-09-11 |
| 32914141 | We combed and drew the knowledge map of the SARS-CoV-2 literature, explored early status of research on etiology, pathology, epidemiology, treatment, prevention, and control, and discussed knowledge gaps that remain to be urgently addressed. […] Future perspectives on treatment, prevention, and control are also presented to provide fundamental references for current and future coronavirus research. | 2020-09-11 |
| 32914175 | A total of 121 responses from physicians in 35 different hospitals were collected (105 inpatient wards, 16 from intensive care units). | 2020-09-11 |
| 32914189 | These observations underline the risk of pulmonary aspergillosis in COVID-19 patients, even in patients not previously known to be immunosuppressed, advocating active search for Aspergillus infection and prompt antifungal treatment. | 2020-09-11 |
| 32914236 | Radiation oncology institutions (ROI) deliver a major component of cancer treatment, with protocols that might span over several weeks, with the result of increasing susceptibility to COVID-19 infection and presenting with a more severe clinical course when compared with the general population. […] The results of the questionnaire showed that a noteworthy number of ROIs were able to complete treatment in SARS-CoV‑2 positive cancer patients, with only a short interruption. […] Most ROIs postponed or cancelled radiation treatment for benign indications (88.1%). […] The occurrence of SARS-CoV‑2 infections did not affect the treatment options for curative procedures. […] Non-university-based ROIs seemed to be more willing to change their treatment options for curative and palliative cases than university-based ROIs. […] Modification and prioritization of treatment regimens and the application of protective measures preserved a well-functioning radiation oncology service and patient care. | 2020-09-11 |
| 32914465 | This is likely to interfere with the course of specifically long-term (high-dose) COVID-19 treatment in some aggravated forms (25% of coronavirus patients were still carrying the virus 6 days after taking hydroxychloroquine). | 2020-09-11 |
| 32914668 | These include interventions delivered by a range of individuals (i.e., community members to mental health professionals), and interventions that vary by implementation (e.g., self-guided therapy, remotely-delivered interventions via telephone or video call). | 2020-09-11 |
| 32914674 | Based on its well-documented anti-inflammatory and restorative properties we propose trials with the natural hormone oxytocin for treatment of hospitalised Covid-19 patients. | 2020-09-11 |
| 32914677 | In mild cases, oral mucosal lesions developed before or at the same time as the initial respiratory symptoms; however, in those who required medication and hospitalization, the lesions developed approximately 7 to 24 d after onset symptoms. | 2020-09-11 |
| 32914732 | There is significant data showing OT would be useful for treatment of COVID-19 pathogenesis. | 2020-09-11 |
| 32915172 | Since the beginning of the COVID-19 pandemic, the treatment of patients with allergic and atopy-associated diseases has faced major challenges. […] This affects both acute care and treatment of the chronically ill. […] The immune response after SARS-CoV-2 infection is so far only insufficiently understood and could be altered in a favorable or unfavorable way by therapy with monoclonal antibodies. […] Many patients are under ongoing therapy with biologicals that inhibit type 2 immune responses via various mechanisms. […] Based on these data, the present position paper provides recommendations for the biological treatment of patients with allergic and atopy-associated diseases during the COVID-19 pandemic. […] In order to maintain in-office consultation services, a safe treatment environment must be created that is adapted to the pandemic situation. […] The use of biologicals for the treatment of bronchial asthma, atopic dermatitis, chronic rhinosinusitis with nasal polyps, and spontaneous urticaria should be continued as usual in patients without suspected infection or proven SARS-CoV-2 infection. […] Treatment should aim at the best possible control of difficult-to-control allergic and atopic diseases using adequate rescue and add-on therapy and should avoid the need for systemic glucocorticosteroids. […] If SARS-CoV-2 infection is proven or reasonably suspected, the therapy should be determined by weighing the benefits and risks individually for the patient in question, and the patient should be involved in the decision-making. | 2020-09-11 |
| 32915476 | However, the diagnosis and treatment of the disease need further exploration. […] Baseline information and clinical records of 40 patients were collected, including demographic data, disease status, medication, and laboratory routine. | 2020-09-11 |
| 32915516 | Cardiac resynchronization therapy was implanted in 0.55% during the study period, 0.32% [odds ratio (OR) 1.66, 95% confidence interval (CI) 0.68-4.04, P = 0.27] in the previous year and 0.43% (OR 1.35, 95% CI 0.64-2.84, P = 0.43) in the same year control. […] Intensive care treatment was 6.22% during the study period, 4.49% in the previous year (OR 1.46, 95% CI 1.13-1.89, P < 0.01), and 5.27% in the same year control (OR 1.19, 95% CI 0.96-1.49, P = 0.12). […] During the early phase of the Covid-19 pandemic in Germany, HF treatment pathways seem not to be affected, but hospital stay shortened and in-hospital mortality increased. | 2020-09-11 |
| 32915649 | During COVID-19 treatment, matrine regulates viral replication, host cell apoptosis, and inflammation by targeting the TNF-α, IL-6, and CASP3 in the TNF signalling pathway. | 2020-09-11 |
| 32915657 | Expert opinion: A case can be made for both open and closed drug discovery models; however, due to the rapidly evolving nature of this deadly virus, organizations should collate their research and support one another to ensure satisfactory treatment can be approved in a timely manner. | 2020-09-11 |
| 32915766 | At present there is insufficient evidence from clinical trials to determine the safety and efficacy of HCQ as a treatment for COVID-19. | 2020-09-11 |
| 32915877 | Therefore, we conducted a systematic review of the clinical efficacy and safety of the traditional Chinese medicine Lianhua Qingwen in the treatment of new coronavirus pneumonia (COVID-19) (referred to as “new coronary pneumonia”), and evaluated the overall level of research quality. […] We included randomized controlled trials (RCTs) that tested the efficacy of the traditional Chinese medicine lotus clearing plague in the treatment of new coronavirus pneumonia. […] The meta-analysis results showed that the disappearance rate of the main clinical symptoms of Chinese medicine Lianhua Qingwen in the treatment of new coronavirus pneumonia was significantly higher than that of the control group [OR = 3.34, 95% CI (2.06, 5.44), P <0.001]; the disappearance rate of other clinical secondary symptoms is significantly higher than the control group [OR = 6.54, 95% CI (3.59, 11.90), P <0.001]. […] It is confirmed that the traditional Chinese medicine Lianhua Qingwen treatment improves the clinical effectiveness, and also has certain advantages in relieving cough and fever. […] The treatment of new pneumonia with traditional Chinese medicine lotus clearing plague can be used as an effective therapy to improve the clinical symptoms of new coronary pneumonia. […] More rigorous design, multi-center, and prospective RCTs are necessary to further determine the effectiveness and safety of the traditional Chinese medicine lotus decoction in the treatment of new pneumonia. | 2020-09-11 |
| 32915959 | Publicly available colonic sc-RNA sequencing data, and microarrays from tissue pre/post anti-TNF therapy, were analyzed. […] Anti-TNF therapy restored colonic ACE2 regulation in responders. | 2020-09-11 |
| 32916218 | This may be further exacerbated by drug-related cardiac toxicity of Covid-19 treatment regimens. | 2020-09-11 |
| 32916249 | RT-PCR testing is conducted on a limited scale and treatment options are few. […] Therefore, what low cost solutions remain for the prevention, diagnosis, and treatment of SARS-CoV-2? […] In this editorial we discuss several important strategies for controlling COVID-19 including: vaccination, molecular and serological diagnostics, hygiene and WaSH interventions, and low-cost therapeutics. | 2020-09-11 |
| 32916258 | We identified ACE2 and also its co-expressed proteins are the potential biomarker and therapy as the current COVID-19 disease and lung cancer. | 2020-09-11 |
| 32916297 | Chloroquine (EC50 = 2.1 μM and EC90 = 3.8 μM), hydroxychloroquine (EC50 = 1.5 μM and EC90 = 3.0 μM), ferroquine (EC50 = 1.5 μM and EC90 = 2.4 μM), desethylamodiaquine (EC50 = 0.52 μM and EC90 = 1.9 μM), mefloquine (EC50 = 1.8 μM and EC90 = 8.1 μM), pyronaridine (EC50 = 0.72 μM and EC90 = 0.75 μM) and quinine (EC50 = 10.7 μM and EC90 = 38.8 μM) showed in vitro antiviral effective activity with IC50 and IC90 compatible with drug oral uptake at doses commonly administered in malaria treatment. | 2020-09-11 |
| 32916371 | The purpose of the present review was to evaluate the potential mechanisms that contribute to this increased risk of coagulopathy and the role of anticoagulants in treatment. […] The National Clinical Trials database was queried for ongoing studies of anticoagulation and/or antithrombotic treatment or the incidence or prevalence of thrombotic events in patients with SARS-CoV-2 infection. […] The phenomenon of breakthrough VTE, or the acute development of VTE despite adequate chemoprophylaxis or treatment dose anticoagulation, has been shown to occur with severe infection. […] Therapeutic anticoagulation therapy might be beneficial for critically ill patients and is the focus of 39 ongoing trials. | 2020-09-11 |
| 32916509 | To date, maximal precautions to prevent coronavirus infection should be maintained in MS/NMOSD patients already exposed to COVID-19 during anti-CD20 therapy. | 2020-09-11 |
| 32916610 | Due to the availability of the calibration standard and the large dynamic range of our assay, we were able to identify “qualified donors” for convalescent serum therapy with only one fixed dilution factor (200 ×). | 2020-09-11 |
| 32916744 | The patient complained of prolonged fever and coughs for 7 days which had not improved after oral treatment with sultamicillin for 5 days, prescribed by the patient’s general practitioner. […] Suspecting a possible secondary bacterial infection at the beginning, intravenous antibiotic treatment with ampicillin/sulbactam was initiated. […] Due to clinical recovery antiviral therapy was not performed after confirming the diagnosis. | 2020-09-11 |
| 32916755 | In addition, as the pandemic continues, strategies to manage patients will need to evolve from a palliative to a more permanent/definitive treatment approach. […] In this article, an update on the treatment considerations for dental care in general is provided, as well as a discussion on the available endodontic guidelines reported in the literature. | 2020-09-11 |
| 32916812 | The experience acquired in SARS and MERS epidemics may prove useful in understanding the SARS-CoV-2 pathomechanism and lead to effective treatment and potential vaccine development. […] The role of interferons in the therapy of these infections is also discussed. | 2020-09-12 |
| 32917141 | The successful establishment of a pediatric biorepository is critical to provide insight into disease pathogenesis, and subsequently, develop future treatment and vaccination strategies. | 2020-09-12 |
| 32917254 | Although no patients exhibited apparent pneumonia, treatment delay or changes in treatment plans were required for a few patients based on the results of screening tests. […] The treatment of five patients, including two patients with cervical cancer, two patients with ovarian tumors, and one patient with ovarian cancer, was affected by the results. […] Two asymptomatic RT-PCR-positive patients did not develop COVID-19, but their treatment was delayed until the confirmation of negative results. […] The other three patients were RT-PCR-negative, but abnormal CT findings suggested the possibility of COVID-19, which delayed treatment. […] The patients receiving first-line preoperative chemotherapy for ovarian cancer had clinically evident exacerbations because of the treatment delay. […] The postponing treatment was the most common, therefore, treatment of ovarian tumors and ovarian cancer was considered to be the most likely to be affected among gynecological diseases. […] Protocols that allow for easy over-diagnosis can be disadvantageous, mainly because of treatment delays, and therefore, the protocols must be developed in light of the local infection situation. | 2020-09-12 |
| 32917259 | The following exclusion criteria: no written consent, chronic respiratory disease, acute or chronic cardiovascular disease, pregnancy or need for special therapy (prone position and/or Extracorporeal membrane oxygenation). […] All other treatment will be unchanged and according to our local policies/guidelines. | 2020-09-12 |
| 32917457 | Voice therapy faces a double challenge, interventions using telepractice, and delivering rehabilitation services to a growing population of patients at risk of functional impairment related to the COVID-19 disease. […] Moreover, as COVID-19 is transmitted through droplets, it is critical to understand how to mitigate these risks during assessment and treatment. […] The clinical guide provides 79 recommendations for clinicians in the management of voice disorders during the pandemic and includes advice from assessment, direct treatment, telepractice, and teamwork. | 2020-09-12 |
| 32917460 | Voice therapy faces a double challenge, interventions using telepractice, and delivering rehabilitation services to a growing population of patients at risk of functional impairment related to the COVID-19 disease. […] Moreover, as COVID-19 is transmitted through droplets, it is critical to understand how to mitigate these risks during assessment and treatment. […] The clinical guide provides 79 recommendations for clinicians in the management of voice disorders during the pandemic and includes advice from assessment, direct treatment, telepractice, and teamwork. | 2020-09-12 |
| 32917566 | The COVID-19 outbreak has had an unclear impact on the treatment and outcomes of patients with ST-segment elevation myocardial infarction (STEMI). | 2020-09-12 |
| 32917722 | Pre-treatment of cultured Vero epithelial cells or freshly isolated human nasal epithelial cells with low concentrations of sphingosine prevented adhesion of and infection with pp-VSV-SARS-CoV-2 spike. […] Our data also suggest that further preclinical and finally clinical examination of sphingosine is warranted for potential use as a prophylactic or early treatment for coronavirus disease-19. | 2020-09-12 |
| 32917843 | A study in China by Wang found that health-care workers on the front line of disease treatment had inadequate training in the use of PPE, particularly for respiratory infectious diseases. | 2020-09-12 |
| 32917848 | This raises the question of whether patients on anti-complement therapy could be protected from COVID-19. […] CASE REPORT Case 1 is a 39-year-old woman with an approximately 20-year history of paroxysmal nocturnal hemoglobinuria (PNH), who had recently been switched from treatment with eculizumab to ravulizumab prior to SARS-CoV-2 infection. […] CONCLUSIONS We see no evidence of increased susceptibility to SARS-CoV-2 in these patients on anti-complement therapy, which might actually have accounted for the mild course of infection. […] The effect of anti-complement therapy on COVID-19 disease needs to be determined in clinical trials. | 2020-09-12 |
| 32917884 | Finally, we test several binding inhibitor peptides targeting the virus early attachment stages, offering new perspectives in the treatment of the SARS-CoV-2 infection. | 2020-09-12 |
| 32918295 | NLR is an easily measurable, available, cost-effective and reliable parameter, which continuous monitoring could be useful for the diagnosis and treatment of COVID-19. | 2020-09-12 |
| 32918300 | To estimate (1) associations between self-reported COVID-19, hand-washing, smoking status, e-cigarette use and nicotine replacement therapy (NRT) use and (2) the extent to which COVID-19 has prompted smoking and vaping quit attempts and more smoking inside the home. […] In England, current smokers and long-term ex-smokers appear to have higher odds of self-reported COVID-19 compared with never smokers in adjusted analyses, but there were no large differences between people who used nicotine replacement therapy or e-cigarettes. | 2020-09-12 |
| 32918447 | Global pandemics call for large and diverse healthcare data to study various risk factors, treatment options, and disease progression patterns. | 2020-09-12 |
| 32918548 | Antiviral therapy for COVID-19 is not necessary for the great majority of pediatric patients. | 2020-09-12 |
| 32918573 | Patients who developed macrophage activation syndrome had significantly higher IL-6 and SP-D levels at the time of admission and on day 5 of treatment compared to the other patients (IL-6: p = 0.001 for both; SP-D: p = 0.02, p = 0.04). […] In addition to IL-6, which has an important role in predicting course and planning treatment in COVID-19, SP-D may be a novel pneumoprotein that can be used in the clinical course, follow-up, and possibly in future treatments. | 2020-09-12 |
| 32918641 | COVID-19 measures that restrict movement may negatively impact access to HIV care and treatment. | 2020-09-12 |
| 32918656 | Lopinavir-ritonavir combination is being used for the treatment of SARS-CoV-2 infection. | 2020-09-12 |
| 32918747 | The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has resulted in an urgent need to understand the pathophysiology of SARS-CoV2 infection, to assist in the identification of treatment strategies. | 2020-09-12 |
| 32918761 | Convalescent plasma is an investigational therapy that may benefit immunosuppressed patients by providing passive immunity. | 2020-09-12 |
| 32918792 | The average age was 58.1 years, 64% were male, 68.3% had comorbidities, and 60% received steroid therapy. […] Tocilizumab therapy was effective at decreasing mortality and should be instituted early in the management of critically ill COVID-19 patients. | 2020-09-12 |
| 32918858 | The pandemic of coronavirus disease 2019 (COVID-19) caused by the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) presents an unprecedented challenge to prevention and treatment. […] We aim to describe the clinical characteristics and risk factors of COVID-19 patients needing use assisted ventilation therapy. […] A binary logistic regression model was used to identify risk factors associated with using CPAP therapy. […] COVID-19 patients with CPAP therapy were older and had higher levels of white blood cells (WBC), procalcitonin (PCT), C-reactive protein (CRP), alanine aminotransferase (ALT), D-dimer, but had lymphopenia. | 2020-09-12 |
| 32918938 | At the time of the event, 10/20 (50%) of patients received thromboprohylaxis, 2/20 (10%) were receiving treatment dose anticoagulation and 5/20 (25%) were receiving antiplatelet therapy. | 2020-09-12 |
| 32918975 | During the course of disease, hs-TnT rose in 8 of the PE-patients above 16 ng/l, 7 had to undergo ventilatory therapy and 4 of them died. | 2020-09-12 |
| 32919186 | Our survey also offers insights into the role that imaging can play in the treatment of comorbid patients, based on probabilities derived from COVID-19 symptom statistics. | 2020-09-12 |
| 32919216 | The COVID-19 pandemic is a global health crisis, and no specific therapy or drug has been formally recommended for use against SARS-CoV-2 infection. […] In this context, it is a rational strategy to investigate the repurposing of existing drugs to use in the treatment of COVID-19 patients. […] There is no doubt that antiviral and supportive treatments are important in the treatment of COVID-19 patients, but anti-inflammatory therapy also plays a pivotal role in the management COVID-19 patients due to its ability to prevent further injury and organ damage or failure. […] Several drugs that possess an anti-inflammatory profile in others illnesses have been studied in respect of their potential utility in the treatment of the hyperinflammation induced by SAR-COV-2 infection. […] In this context, despite their current unproven clinical efficacy in relation to the current pandemic, the repurposing of drugs with anti-inflammatory activity to use in the treatment of COVID-19 has become a topic of great interest. | 2020-09-12 |
| 32919265 | For analysis of prognosis two compound outcomes were defined: positive outcome was defined as either discharge or regular ward care; negative outcome was defined as need for mechanical ventilation, treatment on intensive care unit, extracorporeal membrane oxygenation or death. | 2020-09-12 |
| 32919683 | Further, the review highlights the method of fabrication, biohybrid nanomotors, toxicities along with their application in the field of active drug delivery, diabetes, precise surgery, ischemic stroke therapy, diagnosis and treatment of coronavirus, microwave hyperthermia, zika virus detection, anti-bacterial activity, water treatment and sensing and challenges lying at the forefront in the development of these tiny nanomachines. | 2020-09-13 |
| 32919841 | We provide a short summary of a recently published article titled “Surge capacity of Australian intensive care units associated with COVID-19 admissions” in the Medical Journal of Australia and, importantly, highlight a knowledge gap regarding critical care specialised allied health professional (AHP) workforce planning in Australia. | 2020-09-13 |
| 32919879 | COVID-19 convalescent plasma (CCP) therapy involves the use of circulating antibodies administration from recovered COVID 19 patients as a practical strategy to provide immediate passive immunity in susceptible recipients in need. | 2020-09-13 |
| 32919880 | While convalescent plasma therapy is now being evaluated in prospective clinical trials, we further consider the therapeutic potential of human hyper immune globulins, and of heterologous, engineered and monoclonal neutralizing antibodies as anti-viral agents to treat COVID-19. | 2020-09-13 |
| 32919923 | Coronavirus disease 2019 (COVID-19) has posed unprecedented challenges for nations worldwide, among which medication shortages can cause a devastatingly negative impact on global health. […] Using Taiwan as an example, this report describes the sources of potential medication shortages, discusses the preparedness and contingency strategies to address medication shortages, and outlines the evidence-based recommendations on ensuring a stable medication supply and improving the quality and security of medicines. […] Collaborative inputs and efforts from all these interdependent stakeholders are critical for establishing transparent preparedness and contingency plans to address drug shortages affected by disruptions of overseas manufacturing or stockouts in pharmacies owing to medication misallocation. […] Barriers to accessing medicines are nothing new, but the COVID-19 pandemic poses urgent and even novel challenges to the stability and integrity of medication supply, which urges for a need to reconsider and reinforce effective management strategies for pharmaceuticals. | 2020-09-13 |
| 32920000 | Improvement of COVID-19 clinical condition was seen in studies where combination of antiretroviral drugs, lopinavir and ritonavir, as well as immunomodulant antimalaric, chloroquine/hydroxychloroquine together with the macrolide-type antibiotic, azithromycin, was used for patient’s treatment. […] Thus, by using in silico toxicogenomic data-mining approach, we aimed to assess both risks and benefits of the COVID-19 treatment with the most promising candidate drugs combinations: lopinavir/ritonavir and chloroquine/hydroxychloroquine + azithromycin. […] As expected, inflammation, cardiotoxicity, and dyslipidaemias were revealed as the main risks of lopinavir/ritonavir treatment, while chloroquine/hydroxychloroquine + azithromycin therapy was additionally linked to gastrointestinal and skin diseases. | 2020-09-13 |
| 32920079 | Over the past decade, the growing interest in targeted lung cancer therapy has guided researchers toward the cutting edge of controlled drug delivery, particularly magnetic particle targeting. […] Targeting of tissues by magnetic particles has tackled several limitations of traditional drug delivery methods for both cancer detection (e.g., using magnetic resonance imaging) and therapy. […] It is followed by reviewing the advances in using magnetic particles for diagnosis and therapy of lung cancers: (i) a combination of magnetic particle targeting with MRI imaging for diagnosis and screening of lung cancers, (ii) magnetic drug targeting (MDT) through either intravenous injection and pulmonary delivery for lung cancer therapy, and (iii) computational simulations that models new and effective approaches for magnetic particle drug delivery to the lung, all supporting improved lung cancer treatment. […] The review further discusses future opportunities to improve the clinical performance of MDT for diagnosis and treatment of lung cancer and highlights clinical therapy application of the MDT as a new horizon to cure with minimal side effects a wide variety of lung diseases and possibly other acute respiratory syndromes (COVID-19, MERS, and SARS). | 2020-09-13 |
| 32920095 | With the prediction of the number of patients in hospitals and intensive care units, policy makers could make data driven decisions to potentially avoid overloading the capacities of the healthcare system. | 2020-09-13 |
| 32920103 | Clinical laboratory, and treatment data of inpatients with laboratory-confirmed COVID-19 were collected and analyzed. | 2020-09-13 |
| 32920170 | In the absence of demonstrated treatment and while waiting for vaccine possibility, the use of omega-3 LC-PUFAs deserve therefore to be considered, based on previous clinical studies suggesting that omega-3 supplementation could improve clinical outcomes of critically ill patients at the acute phase of ARDS. | 2020-09-13 |
| 32920232 | NI/I-VS was defined as the need for continuous positive airway pressure (CPAP) or bilevel positive airway pressure (BPAP) (non-invasive ventilation) or mechanical ventilation, not including low-flow systems of oxygen therapy such as the Venturi mask or nasal cannula. […] Thirty-five of the 97 patients (36%) required ICU admission and 94.8% (92/97) were prescribed oxygen therapy: 10.8% (10/92) by nasal cannula, 44.5% (41/92) by Venturi mask, 31.5% (29/92) by CPAP, 2.2% (2/92) by BPAP, and 10.8% (10/92) by mechanical ventilation following intubation. | 2020-09-13 |
| 32920233 | It has a negative influence on antibody therapy for viral infection. | 2020-09-13 |
| 32920234 | Zinc is a trace element with potent immunoregulatory and antiviral properties, and is utilized in the treatment of coronavirus disease 2019 (COVID-19). […] These patients were found to have higher rates of complications (p = 0.009), acute respiratory distress syndrome (18.5% vs 0%, p = 0.06), corticosteroid therapy (p = 0.02), prolonged hospital stay (p = 0.05), and increased mortality (18.5% vs 0%, p = 0.06). | 2020-09-13 |
| 32920291 | Our findings provide novel insights into the molecular mechanism of CQ and HCQ treatment effect on virus infection. | 2020-09-13 |
| 32920373 | A total of 72 PWE (19.6%) reported problems to obtain antiseizure medication (ASM), which in 25% of cases was directly COVID-related. […] A planned follow-up consultation with the treating physician was associated with a lower risk of depression, whereas difficulties to access ASM treatment increased the odds of depression. […] Innovative approaches are needed to ensure continuity in access to ASM treatment. | 2020-09-13 |
| 32920389 | The impacts including change in waste amount, composition, timing/frequency (temporal), distribution (spatial) and risk, which affects the handling and treatment practices. | 2020-09-13 |
| 32920511 | Owing to the more metabolic plasticity of uninfected cells, a promising approach for specific antiviral therapy, which has drawn a lot of attention in the recent years, would be the targeting of metabolic changes induced by viruses. | 2020-09-13 |
| 32920514 | Cytokine storm syndrome (CSS) is a severe complication of inflammatory immune diseases or treatment of malignancies; it may also appear during the progression of COVID-19. […] Currently, IL-6 inhibitor therapeutics are not yet approved for the treatment of COVID-19; however, these medicines, including tocilizumab (TCZ) are used off-label for the treatment of patients with severe COVID-19, including life-threatening conditions. […] These issues include the indications for treatment with IL-6 inhibitors, as well as the estimation of risk associated with the disease, outcomes, treatment options, and adverse drug reactions. […] The development of personalized immunomodulatory therapy, with respect to the role of cytokines in pathogenesis, requires the studies that aimed to find other relevant therapeutic targets for the treatment of CSS in patients with COVID-19. […] Hopefully, the significant efforts of scientists and physicians across the globe will improve the prognosis in COVID-19 patients and provide useful information on IMIDs required to support the struggle for treating potential viral outbreaks, and treatment of well-known IMIDs. | 2020-09-13 |
| 32920544 | What makes the condition the worst of all is no specific effective treatment available. | 2020-09-13 |
| 32920570 | Anti-viral treatment was given to 27 (65.8%) of 41 patients. | 2020-09-13 |
| 32920571 | Convalescent plasma therapy is an effective therapy if donors with high level of SARS-Cov2 antibodies are selected and if recipients are at their early stage of critical illness, being no more than three days in RCUs. | 2020-09-13 |
| 32920634 | The evolving, highly contagious global viral spread has created a pressure test of unprecedented proportions for the existing brain health care infrastructure and related services for management, diagnosis, treatment, and prevention. | 2020-09-13 |
| 32920752 | This compilation emphasizes Mesenchymal Stem Cells (MSCs) based therapy alone or in combination with other therapeutics as an attractive curative approach for COVID-19 pandemic. […] However, as of now, there is no WHO-approved MSCs based therapy for the treatment of COVID-19 infection. | 2020-09-13 |
| 32920756 | Anti-Vascular endothelial growth factor (anti-VEGF) strategies are currently investigated for treatment of severe and critically ill Covid-19 patients, but also FGF2, and its expression and/or signaling, might represent a promising target. | 2020-09-13 |
| 32920811 | For patients with VD-CVR who receive home treatment for COVID-19, VAS recommends assessment for (1) disease worsening risk and prioritized hospitalization of those at high risk and (2) VTE risk assessment and thromboprophylaxis with rivaroxaban, betrixaban, or low-molecular-weight heparin (LMWH) for those at high risk. […] For hospitalized patients with VD-CVR and COVID-19, VAS recommends (1) routine thromboprophylaxis with weight-adjusted intermediate doses of LMWH (unless contraindication); (2) LMWH as the drug of choice over unfractionated heparin or direct oral anticoagulants for the treatment of VTE or hypercoagulability; (3) careful evaluation of the risk for disease worsening and prompt application of targeted antiviral or convalescence treatments; (4) monitoring of D-dimer for optimization of the antithrombotic treatment; and (5) evaluation of the risk of VTE before hospital discharge using the IMPROVE-D-dimer score and prolonged post-discharge thromboprophylaxis with rivaroxaban, betrixaban, or LMWH. | 2020-09-13 |
| 32921195 | The best proposed healthcare model for telemedicine in hypertension management should include remote monitoring and transmission of vital signs (notably blood pressure) and medication adherence plus education on lifestyle and risk factors, with video consultation as an option. | 2020-09-14 |
| 32921198 | We review the multisystem complications of COVID-19 and associated treatment strategies to improve the care of critically ill COVID-19 patients. | 2020-09-14 |
| 32921214 | The potential life-long morbidity as a result of the infection and as a consequence of highly invasive critical care treatment needs to be factored into the rehabilitation of survivors. […] The implications of the closure of many healthcare services over the initial lockdown will also have both a shorter- and longer-term impact on other diseases due to missed early diagnosis and disrupted treatment regimes. | 2020-09-14 |
| 32921249 | The cause of some patients with negative RT-PCR results experienced turn-positive after treatment remains unclear. […] In addition, understanding the correlation between changes in clinical data in the course of COVID-19 and treatment outcomes is of great importance in determining the prognosis of COVID-19. […] To perform cause analysis of RT-PCR turn-positive and the effective screening factors related to treatment outcome in COVID-19. […] Clinical data, including clinical manifestations, laboratory tests, radiography results, treatment methods and outcomes, were retrospectively collected and analyzed from January to March 2020 in Renmin Hospitals of Wuhan University. | 2020-09-14 |
| 32921279 | Where the information revealed from our examinations can support precision vaccine design and the discovery of antiviral therapeutics, which will accelerate the development of medical countermeasures, the World Health Organization recently reported on the possible risks of reciprocal infections regarding SARS-CoV-2 transmission from animals to humans. | 2020-09-14 |
| 32921324 | Results show wide variation regarding the location, team size and composition, service availability, numbers of patients attending, and inpatient treatment length. | 2020-09-14 |
| 32921705 | Ten female thalassemia patients with positive COVID-19 had hypogonadism, six patients were receiving hormone replacement therapy and all of them recovered (zero death) compared to two deaths from 4 patients who were not receiving hormone replacement therapy (P:0.133). | 2020-09-14 |
| 32921708 | They had significantly higher systolic and diastolic blood pressures, longer duration of hospitalization, ICU stay, mechanical ventilation and oxygen therapy. | 2020-09-14 |
| 32921712 | Conversely, the low frequency of positive HCWs in intensive care units is probably explained by the diffuse and continuous use of PPD. | 2020-09-14 |
| 32921714 | Given the current absence of a vaccine against SARS-COV-2 and the lack of a specific treatment for -COVID-19, prevention strategies are of extreme importance. | 2020-09-14 |
| 32921718 | Besides, we described useful maps for the better treatment of COVID-19 infection in patients with underlying cardiovascular conditions, as a high-risk group of patients. | 2020-09-14 |
| 32921719 | COVID-19 has had a catastrophic effect on healthcare systems compromising the treatment of cancer patients. | 2020-09-14 |
| 32921720 | Severe acute respiratory distress syndrome (ARDS) is the main cause of death: its management and treatment should be tailored to the individual COVID-19 patient’s phenotype. […] Early diagnosis of COVID-19 is paramount for disease treatment and infection control. […] We strongly recommend clinicians to maintain a high index of suspicion for COVID-19, regardless of the persistence negativity of NP swabs, and not to delay the initiation of therapy in presence of typical clinical, radiological and laboratory findings of COVID-19. | 2020-09-14 |
| 32921726 | This narrative review aims to provide a comprehensive overview of epidemiological, pathogenic and clinical features, along with diagnosis and treatment, of the ongoing epidemic of new coronavirus disease 2019 (COVID-19) in the pediatric population in comparison to the first two previous deadly coronavirus outbreaks, SARS and MERS. | 2020-09-14 |
| 32921728 | We report a summary of the current evidence about clinical features, pathogenesis, therapy strategies and outcome of this novel syndrome. | 2020-09-14 |
| 32921732 | No specific therapy for SARS-CoV-2 has yet been identified, but since the beginning of the outbreak, several pre-existing therapeutics have been reconsidered for the treatment of infected patients. […] The aim of this article is to discuss current therapeutics against SARS-CoV-2. […] Moreover, choice of therapy must always be tailored on clinical manifestations and, when they occur, drugs able to fight coagulopathy and venous thromboembolism that may contribute to respiratory deterioration must be prescribed. | 2020-09-14 |
| 32921746 | This arrangement has involved structural and organizational changes almost daily, with great efforts of the health personnel, but allowing our hospital to be the only one in the area still able to guarantee patients safe access to surgical treatment. | 2020-09-14 |
| 32921747 | It is imperative to establish the real risk of intrauterine transmission and to develop appropriate preventive and treatment strategies. | 2020-09-14 |
| 32921751 | We provided details about the daily transaminases trend, the therapy used and the maternal/neonatal outcomes. | 2020-09-14 |
| 32921820 | Since 1999, music therapy has been offered at the neonatal intensive care unit in cooperation with the University of Music and Performing Arts, Vienna (mdw). | 2020-09-14 |
| 32921830 | Which aspects of the coronavirus infection relate to rheumatological therapy and practice? […] The constantly new and tested concepts in the treatment of COVID testify to the growing knowledge about the virus, but also to the need for more targeted therapy. […] Treatment regimens have been developed for both patients with COVID-19 and those with symptomatic SARS-CoV infection and rheumatic disease. | 2020-09-14 |
| 32921862 | Rapid and accurate detection of COVID-19 coronavirus is necessity of time to prevent and control of this pandemic by timely quarantine and medical treatment in absence of any vaccine. | 2020-09-14 |
| 32921917 | The immediate challenges to consider while considering wastewater management are uncertainty about this new biothreat, relying on prediction based treatments options, significant population being the latent asymptomatic carrier increased risk of passing out of the virus to sewage network, inadequacy of wastewater treatment facility particularly in populated developing countries and increased generation of wastewater due to increased cleanliness concern. […] In absence of regulated central treatment facility, installation of decentralized wastewater treatment units with single or multiple disinfection barriers in medical units, quarantine centre, isolation wards, testing facilities seems to be urgent for minimizing any potential risk of wastewater transmission. […] However, there is need of additional research on coronaviruses specific disinfection data generation, regular monitoring of performance considering all factors influencing virus survival, performance evaluation in actual water treatment, need of augmenting disinfection dosages, environmental considerations to select the most appropriate disinfection technology. | 2020-09-14 |
| 32921928 | The coronavirus pandemic of recent months has highlighted the fact that death is still a taboo regardless of the progress that has been made in palliative care. | 2020-09-14 |
| 32921930 | This overview article gives a more detailed description of some aspects relevant for vascular medicine, e.g. emergency treatment, increase of the cardiovascular risk due to social distancing and the risk of venous thromboembolisms. | 2020-09-14 |
| 32921952 | As for the choice of surgical treatment options, no differences were found between 2019 and 2020. | 2020-09-14 |
| 32921955 | Although liver injuries in COVID-19 are often transient and reversible, health workers need to pay attention to preexisting liver disease, monitor liver function, strengthen supportive treatment, and reduce the chance of drug-induced liver injury. | 2020-09-14 |
| 32921965 | Since the first detection, in December 2019, there have been no effective drug therapy options for treating the SARS-CoV-2 pandemic. […] This study aims to compare the biological, molecular, pharmacological, and clinical characteristics of these three treatment modalities for SARS-COV-2 infections, Chloroquine and Hydroxychloroquine, Convalescent Plasma, and Remdesivir. […] The search was based on keywords “COVID-19” SARS-COV-2, chloroquine, hydroxychloroquine, convalescent plasma, remdesivir and treatment modalities. […] We selected 17 relevant published original articles and clinical trials: 05 for chloroquine and/or hydroxychloroquine with total sample size (n = 220), 05 for Remdesivir (n = 1,781), and 07 for Convalescent Plasma therapy (n = 398), with a combined total sample size (n = 2,399). […] Based on the available data, convalescent plasma therapy showed clinical advantages in SARS-COV-2 patients. […] All three treatment modalities have both favorable and unfavorable characteristics, but none showed clear evidence of benefit for early outpatient disease or prophylaxis. […] Based on the current available data, convalescent plasma therapy appears to show clinical advantages for inpatient use. […] In the future, ongoing large sample size randomized controlled clinical trials may further clarify the comparative efficacy and safety of these three treatment classes, to conclusively determine whom to treat with which drug and when to treat them. | 2020-09-14 |
| 32922049 | The coinfecting pathogens can be detected at variable intervals during COVID-19 disease course and remain an important consideration in targeted treatment strategies for COVID-19 patients. | 2020-09-14 |
| 32922162 | Under these circumstances, we propose here an exposition of some of the nanotechnological products (nanoscale between 1 to 1000 nm) currently designed for the detection of the virus, for the prevention and treatment of COVID-19, in addition to equipment for personal protection. | 2020-09-14 |
| 32922180 | With the effective antiviral treatment, all the 70 asymptomatic infections had been discharged, none cases developed severe pneumonia, admission to intensive care unit, or died. | 2020-09-14 |
| 32922203 | Background: In patients with coronavirus disease 2019 (COVID-19) pneumonia, whether new pulmonary lesions will continue to develop after treatment was unknown. […] This study aimed to determine whether new pulmonary lesions will develop after treatment in patients with COVID-19 pneumonia, and investigate their CT features and outcomes. […] The CT manifestations of primary and newly developed pulmonary lesions and their changes after treatment were mainly evaluated. […] Results: Among the 56 patients (mean age: 48±15 years, 35 men) with COVID-19 pneumonia, 42 (75.0%) patients developed new pulmonary lesions during treatment. […] Of the 42 patients, 30 (71.4%) patients developed new lesions once, and 12 (28.6%) twice or thrice, which usually appeared when primary lesions were progressing (37, 88.1%) and 1-15 days after treatment. […] Conclusion: During treatment, most patients with COVID-19 pneumonia will develop new pulmonary lesions, which usually manifest as multiple GGOs distributed around the primary lesions or in previously uninvolved lobes, and are subsequently absorbed directly. | 2020-09-14 |
| 32922210 | Clearly, it is essential to find an immunological treatment that controls the “cytokine storm”. […] Hydroxychloroquine or chloroquine have been widely adopted worldwide for the treatment of SARS-CoV-2 pneumonia. […] However, the choice of this treatment was based on low quality of evidence, i.e. retrospective, non-randomized controlled studies. […] These three ‘Recovery’ RCTs concluded definitely: (a) that treatment with hydroxychloroquine provides no benefits in patients hospitalized with COVID-19; (b) that treatment with dexamethasone reduced deaths by one-third in COVID-19 patients that were mechanically ventilated, and by one-fifth in patients receiving oxygen only; (c) that the combination of Lopinavir and Ritonavir is not effective in reducing mortality in COVID-19 hospitalized patients. […] The results of these four large RCTs have provided sound indications to doctors for the treatment of patients with COVID-19 and prompted the correction of many institutional provisions and guidelines on COVID-19 treatments (i.e. […] Even though a definitive treatment for COVID-19 has not yet been found, large RCTs stand as the Gold Standards for COVID-19 therapy and offer a solid scientific base on which to base treatment decisions. | 2020-09-14 |
| 32922211 | Another challenge for the hemostasis laboratory is the monitoring of heparin treatment, especially unfractionated heparin in the setting of an extreme inflammatory response. | 2020-09-14 |
| 32922212 | Hospitals in the Middle East Gulf region have experienced an influx of COVID-19 patients to their medical wards and intensive care units. […] The effect of the current treatment protocols on patients’ diagnostic and prognostic biomarkers may thus impact the validity of the algorithms adopted. […] Tocilizumab has been utilized as an add-on therapy to the standard of care to treat patients with SARS-CoV-2 associated acute respiratory distress syndrome, in order to dampen the hyperinflammatory response. […] In the setting of tocilizumab therapy, traditional prognostic markers of worsening infection and inflammation, and thus potential risk of acute thrombosis, should be weighed carefully as they may not be reliable for prognosis and may create a façade of an improved prognostic outcome insteasd. | 2020-09-14 |
| 32922220 | To minimize the disruption of care due to the necessary constraints dictated by COVID-19, the televisit provides a practical solution that can assess the child’s current level of symptom control, reinforce asthma education, and determine treatment options. | 2020-09-14 |
| 32922301 | Anti-TNF alpha treatment with antibodies is already available and needs to be tested in randomized controlled trials of COVID 19 lung disease. | 2020-09-14 |
| 32922409 | Treatment was well-tolerated. […] C1INH concentrations were elevated before conestat alfa treatment. […] Levels of complement activation products declined after treatment. | 2020-09-14 |
| 32922517 | The disclosure in the media of a benefit with the use of dexamethasone in patients with COVID-19 infection sets precedents for self-medication and inappropriate use of corticosteroids. […] Fear and uncertainty toward a potentially serious infection may lead people to self-medication and the inappropriate and abusive use of corticosteroids. | 2020-09-14 |
| 32922769 | The COVID-19 pandemic has necessitated temporary modifications in the current head and neck oncology treatment paradigm. […] Till date, no definite treatment for COVID-19 has been discovered. | 2020-09-14 |
| 32922804 | In this study, we showed the recovery of three individuals with COVID-19 after including dornase alfa in their treatment. […] We followed clinical improvement in the radiological analysis (two of three cases), oxygen saturation (Spo2), respiratory rate, disappearance of dyspnoea, coughing and a decrease in NET formation and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) viral load after the treatment. | 2020-09-14 |
| 32922853 | Cytokine-storm, increased thromboembolic state, deranged overall homeostasis and aggressive medical treatment can cause a variety of lesions in the central nervous system. […] Interpretation of brain imaging findings will require a thorough understanding of the clinical status of the patient and treatment being offered, keeping in mind the several ways in which the viral pathogen, severe acute respiratory syndrome coronavirus-2 may interact with brain tissue. | 2020-09-14 |
| 32923016 | No therapeutics have been proven effective yet for the treatment of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). […] To assess the efficacy and safety of Triazavirin therapy for COVID-19, we conducted a randomized, double-blinded controlled trial involving hospitalized adult patients with COVID-19. […] We randomized 52 patients for treatment with Triazavirin (n = 26) or a placebo (n = 26). | 2020-09-14 |
| 32923084 | In conclusion this study proposed next step in combating COVID-19 infection through mass survey of high risk people then application of specific precautions to them, perhaps they could be candidate for future vaccine or prophylactic treatment. | 2020-09-14 |
| 32923151 | Amid controversial reports that COVID-19 can be treated with a combination of the antimalarial drug hydroxychloroquine (HCQ) and the antibiotic azithromycin (AZI), a clinical trial (ONCOCOVID, NCT04341207) was launched at Gustave Roussy Cancer Campus to investigate the utility of this combination therapy in cancer patients. | 2020-09-14 |
| 32923230 | However, he did not respond to the therapy and was started on re-induction therapy with decitabine and venetoclax. […] In our discussion, we review the current principles of treatment of patients with concurrent COVID-19 and AML. | 2020-09-14 |
| 32923243 | Immunosuppression is the corner stone of the treatment and if left untreated, the death toll increases dramatically. | 2020-09-14 |
| 32923248 | Treatment options were then shifted towards either temporary surveillance or hormone therapy. […] Radiation Oncologists indicated that prostate cancer patients ready to start treatment were mostly delayed with temporary surveillance or hormone therapy depending on risk category (60% indicated they delayed low risk and favorable intermediate risk cases, 56% unfavorable intermediate risk cases, and 44% high risk cases). […] More than 80% of patients already undergoing treatment continued radiation. […] The long-term outcomes of delays and deviations from standard treatment approaches will remain to be seen. | 2020-09-14 |
| 32923288 | Upon follow-up, her pain improved and she was prescribed a wrist splint, ultram, and occupational therapy for perceived wrist tendinitis. | 2020-09-14 |
| 32923299 | Methods Thirty patients with osteoporosis with no delays in their regular medication who received care at our hospital’s osteoporosis outpatient clinic within one month after the end of the state of emergency were included. […] Conclusion Bone health in patients with osteoporosis was maintained during the short-term COVID-19 stay-at-home order among patients who experienced no delays in medication. | 2020-09-14 |
| 32923357 | The Acceptance and Commitment Therapy (ACT) framework conceptualizes psychological flexibility as an important way to reduce the impact of painful and even catastrophic events on psychological suffering. […] Implications of patterns of results across different facets for treatment approach are discussed. | 2020-09-14 |
| 32923374 | Although repurposing of known drugs currently provides an accelerated route to approval, there is no satisfactory treatment. | 2020-09-14 |
| 32923381 | In the current SARS-CoV-2 disease (COVID-19) pandemic, the structural understanding of new emerging viruses in relation to developing effective treatment and interventions are very necessary. | 2020-09-14 |
| 32923397 | The first challenge, therefore, is how to continue to deliver effective, curative therapy to vulnerable patients and at the same time avoid exposing them, and their health care teams (HCT), to SARS-CoV-2. […] An additional challenge is the timely completion of the diagnostic and staging studies required to formulate appropriate treatment plans. […] Finally, we are increasingly faced with the challenge of making complex treatment decisions in SARS-CoV-2 positive patients with aggressive but potentially curable blood cancers. | 2020-09-14 |
| 32923450 | During the patient’s 25-day treatment, we performed cardiopulmonary resuscitation twice. | 2020-09-14 |
| 32923657 | Conclusion: Our results suggest a potential protective role for CBD during ARDS that may extend CBD as part of the treatment of COVID-19 by reducing the cytokine storm, protecting pulmonary tissues, and re-establishing inflammatory homeostasis. | 2020-09-14 |
| 32923679 | Moreover, some of the Disease-Modifying Anti-Rheumatic Drugs (DMARDS) commonly used to treat rheumatic diseases like Hydroxychloroquine (HCQ) were proposed as a potential therapy for COVID-19 with a lack of full understanding of their molecular mechanisms. […] Moreover, our results also highlighted a possible mechanism through which HCQ, which can be used as a monotherapy in mild RA or as one of the triple-DMARDs therapy (tDMARDs; methotrexate, sulphasalazine, and HCQ), might interfere with the COVID-19 infection. | 2020-09-14 |
| 32923691 | Virtual health services including asynchronous secure clinical communications, real-time virtual care via messaging, telephony or video conferencing (telehealth) and ancillary functions like triage, scheduling, documentation and reporting, the previously established virtual hospital program with home monitoring, virtual health assessments, medication review, education and support for patients and families and coordination between family doctors, specialists and other health team members help to control viral transmission, protect healthcare personnel and save supplies. […] Moreover, rapid launch of online screening and triage tools to guide testing and isolation, online result sharing, infected patient and contact tracing including a smartphone exposure tracking application (ABTraceTogether), electronic best practice alerts and decision support tools, test and treatment order sets for standardized COVID-19 management, continuous access to population level real-time data to inform healthcare provider, public health and government decisions have become key factors in the management of a global crisis in Alberta. | 2020-09-14 |
| 32923742 | The patient was then admitted for observation and supportive therapy. | 2020-09-14 |
| 32923747 | Therefore, this review aims at summarizing the literature of a novel miRNA-based therapy and its potential applications in COVID-19-associated nephropathy. […] Therefore, the antimiR-18 roles were summarized in various primate models that aided in developing the therapy for ACE2 related diseases. | 2020-09-14 |
| 32923991 | We assessed outcome of patients with moderate and severe COVID-19 following treatment with convalescent plasma (CP) and the association with IgG levels in transfused CP. […] Antibody levels in CP units were unknown at the time of treatment. […] In patients diagnosed >10 days prior to treatment, 4/14 (22.4%) improved in the ≤4.0 antibody group, versus 6/7 (85.7%) in the >4.0 antibody group, OR 0.048 (95% CI, 0.004-0.520), P = 0.007. […] Treatment with CP with higher levels of IgG against S1 may benefit patients with moderate and severe COVID-19. | 2020-09-14 |
| 32923995 | Treatment preferences were collected in five different clinical scenarios. | 2020-09-14 |
| 32924007 | Each case was characterized by little in-vivo hemolysis, but these antibodies complicated laboratory assessment and renal replacement therapy. […] Despite minimal in-vivo hemolysis, these antibodies are of clinical significance given their implications for laboratory assessment and renal replacement therapy, particularly with the frequency of multi-organ system dysfunction associated with severe Covid-19. | 2020-09-14 |
| 32924020 | The aim of this article is to critically appraise the evidence that form the rationale behind these guidelines and to review the alternative treatment options for the management of shoulder pain during the COVID-19 pandemic. | 2020-09-14 |
| 32924059 | Serious complications occur frequently and respond to aggressive supportive therapy. | 2020-09-14 |
| 32924089 | Provide the most recent updates on the epidemiology, pathogenesis, and treatment advances in Kawasaki disease. […] Treatment advances in complex, IVIG-refractory cases of Kawasaki disease. | 2020-09-14 |
| 32924219 | Such a therapeutic can be readily manufactured at low cost as a potential treatment for COVID-19. | 2020-09-14 |
| 32924229 | We aimed to describe the clinical characteristics, treatment and outcomes of patients with COVID-19 pneumonia, in particular older patients, admitted to tertiary and partner hospitals in Saitama, Japan. […] Our report illustrates that appropriate treatment, taking patient background into consideration, may improve their condition regardless of age. | 2020-09-14 |
| 32924344 | The purpose was to develop recommendations on how to minimize the risk of infection while enabling subjects to take part in the trials if no better alternative treatment options were available. | 2020-09-14 |
| 32924345 | The stability of SARS-CoV-2 varied according to the water matrix: infective SARS-CoV-2 was undetectable after treatment with fresh water and seawater, but remained detectable for 2 days in tap water, when starting with an initial concentration of 10⁴ PFU/mL. | 2020-09-14 |
| 32924540 | The COVID-19 outbreak poses special challenges to the administration of electroconvulsive therapy (ECT) since the anaesthetic induction is an aerosol-generating process. | 2020-09-14 |
| 32924567 | Various medical societies have issued guidelines or consensus statements regarding thromboprophylaxis and treatment of these thrombotic complications specifically adapted to COVID-19 patients. | 2020-09-14 |
| 32924650 | The objective of this systematic review is to identify studies pertaining to antivirals, both as sole and combined therapies, in COVID-19 patients and review the clinical outcomes of these treatment methods. […] This should optimize treatment efficacy and improve patient outcomes. | 2020-09-14 |
| 32924825 | The health sector has been on the race to find a potent therapy for coronavirus disease (COVID)-19, a diseases caused by severe acute respiratory syndrome coronavirus (SARS-CoV)-2. | 2020-09-14 |
| 32924956 | This is a 24-week, prospective, observational cohort study comprising patients from public and private health services across Brazil, who chronically use antimalarials for the treatment of immune-mediated rheumatic diseases, osteoarthritis, or chikungunya-related arthropathy. […] Information regarding social, epidemiological, and demographic data, as well as details about rheumatic diseases, antimalarials, comorbidities, and concomitant medication, is being recorded using a specific online form in the REDCap database. | 2020-09-14 |
| 32924964 | Among the proposed therapeutic regimen, hydroxychloroquine, chloroquine, remdisevir, azithromycin, toclizumab and cromostat mesylate have shown promising results, and limited benefit was seen with lopinavir-ritonavir treatment in hospitalized adult patients with severe COVID-19. […] This article concludes and highlights ongoing advances in drug repurposing, therapeutics and vaccines to counter COVID-19, which collectively could enable efforts to halt the pandemic virus infection. | 2020-09-14 |
| 32925078 | The goal of this paper is to provide a comprehensive review of SARS-CoV-2-induced disease, its mechanism of infection, diagnostics, therapeutics, and treatment strategies, while also focusing on less attended aspects by previous studies, including nutritional support, psychological, and rehabilitation of the pandemic and its management. […] There are 28 vaccines under development, and new treatment strategies/protocols are being investigated. […] The mental health and illness aspect of COVID-19 are among the most important side effects of this pandemic which requires a national plan for prevention, diagnosis and treatment. | 2020-09-14 |
| 32925133 | So far, no vaccine or definitive treatment for COVID-19 has been invented, and the disease has become a pandemic. | 2020-09-14 |
| 32925134 | The predisposing comorbidities, viral mechanism of action and treatment regimen were also searched. | 2020-09-14 |
| 32925151 | Prior to the COVID-19 global health emergency, telehealth was an emerging occupational therapy (OT) service delivery model possessing many positive attributes. […] These include the potential to offset well-documented global occupational therapy practitioner (OTP) shortages. […] Prior to the COVID-19 global health emergency, school-based occupational therapy practitioners (OTP) experienced in telehealth were invited to complete a survey exploring benefits and barriers encountered in the delivery of OT services using telehealth. | 2020-09-14 |
| 32925166 | In support of the hypothesis that the complement system along with neutrophils and platelets contributes to COVID-19, the authors present empirical evidence showing that treatment with the complement inhibitor compstatin Cp40 inhibited the expression of tissue factor in neutrophils. […] These results confirm that the complement axis plays a critical role and suggest that targeted therapy using complement inhibitors is a potential therapeutic option to treat COVID-19-induced inflammation. | 2020-09-14 |
| 32925396 | We describe the diagnosis, treatment and outcome of a 4-year-old boy with high-risk acute lymphoblastic leukemia and COVID-19. […] He received only supportive treatment. […] Despite prolonged myelosuppression he did neither acquire secondary infections nor did the treatment delay caused by the infection have a measurable negative impact on the residual disease of acute lymphoblastic leukemia. […] Intriguingly, residual leukemia even decreased even though he did not receive any antileukemic therapy. | 2020-09-14 |
| 32925489 | Additionally, what is learned from health care providers’ experiences delivering palliative care during a pandemic can be incorporated into daily practice as social isolation and loneliness are long-standing challenges for the elderly population. | 2020-09-14 |
| 32925581 | The median period from the non-invasive mechanic ventilation (NIV) or high-flow nasal cannula oxygen therapy (HFNC) to intubation was 7 hours (IQR 2-42) in IMV survivors and 54 hours (IQR 28-143) in IMV non-survivors. […] Multiple organ damage was common among these non-survivors in the course of treatment. | 2020-09-14 |
| 32925589 | There are multiple telehealth platforms that require careful planning and treatment implementation. | 2020-09-14 |
| 32925737 | There is currently no specific and effective drug treatment. […] However, there is no evidence-based medicine to confirm the effectiveness and safety of CQ and HCQ in the treatment of COVID-19 patients with diabetes. […] This study will explore the effectiveness and safety of CQ and HCQ in the treatment of COVID-19 patients with diabetes. […] It will provide evidence-based medical evidence for CQ and HCQ in the treatment of diabetes with COVID-19. | 2020-09-14 |
| 32925756 | Bromhexine hydrochloride tablets may be effective in the treatment of Coronavirus disease 2019 (COVID-19) in children. […] This study will further evaluate the efficacy and safety of bromhexine hydrochloride tablets in the treatment of COVID-19 in children. […] This systematic review will evaluate the current status of bromhexine hydrochloride in the treatment of COVID-19 in children, to evaluate its efficacy and safety. […] This study will provide the latest evidence for evaluating the efficacy and safety of bromhexine hydrochloride in the treatment of COVID-19 in children. | 2020-09-14 |
| 32925800 | With the improvement of diagnosis and treatment level in various countries, more and more patients have recovered. […] It can be used as an alternative therapy for COVID-19 rehabilitation patients. | 2020-09-14 |
| 32925832 | In addition, progression of disease and delay in treatment can result in cranial nerve deficits, intracranial and life-threatening complications, and/or irreversible consequences. | 2020-09-14 |
| 32926097 | Our results support the hypothesis that NETs may represent drivers of severe pulmonary complications of COVID-19 and suggest that NET-targeting approaches could be considered for the treatment of uncontrolled tissue-damaging and thrombotic responses in COVID-19. | 2020-09-14 |
| 32926319 | The cases that received TCM treatment had lower death rates than those that did not receive TCM treatment (17/273 = 6.2% vs. […] The TCM herbal prescriptions used for the treatment of COVID-19 infections mainly consisted of Pericarpium Citri Reticulatae, Radix Scutellariae, Rhizoma Pinellia, and their combinations, which reflected the practical TCM principles (e.g., clearing heat and dampening phlegm). […] Lastly, 59% of the patients received treatment, including antiviral, antibiotics, and Chinese patent medicine, before admission. […] Our results preliminarily showed the potential effectiveness of TCM herbal prescriptions and their regularities in COVID-19 treatment. | 2020-09-14 |
| 32926453 | Despite some advances in drug treatments of medical complications in the later stages of the disease, the pandemic’s death toll is tragic, as no vaccine or specific antiviral treatment is currently available. | 2020-09-14 |
| 32926573 | Conflicting evidence regarding the use of hydroxychloroquine (HCQ) and azithromycin for the treatment of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection do exist. […] Of these, 297 were in combination treatment, 17 were on HCQ alone, and 63 did not receive either of these 2 drugs because of contraindications. […] We recorded 146 deaths: 35 in no treatment, 7 in HCQ treatment group, and 102 in HCQ + azithromycin treatment group (log rank test for Kaplan-Meier curve P < 0.001). […] At multivariable Cox proportional hazard regression analysis, age (hazard ratio (HR) 1.057, 95% confidence interval (CI) 1.035-1.079, P < 0.001), mechanical ventilation/continuous positive airway pressure (HR 2.726, 95% CI 1.823-4.074, P < 0.001), and C reactive protein above the median (HR 2.191, 95% CI 1.479-3.246, P < 0.001) were directly associated with death, whereas use of HCQ + azithromycin (vs. no treatment; HR 0.265, 95% CI 0.171-0.412, P < 0.001) was inversely associated. | 2020-09-14 |
| 32926676 | This case illustrates the importance of prompt recognition and treatment of sequelae of COVID-19 infections. | 2020-09-14 |
| 32926681 | The patient was intubated during the treatment course due to persistent hypoxemia and for airway protection after resuscitation. | 2020-09-14 |
| 32926682 | The patient underwent further workup and treatment with intravenous corticosteroids with improvement of symptoms and a discharge diagnosis of ATM secondary to SARS-CoV-2. | 2020-09-14 |
| 32926684 | Prompt recognition and diagnosis can minimize the risk of transmission to hospital staff and facilitate initiation of treatment. | 2020-09-14 |
| 32926753 | We also constructed a questionnaire, exclusive to surgeons, to determine the changes in treatment strategies as well as the response to the pandemic. | 2020-09-14 |
| 32926779 | Broad-spectrum antivirals are powerful weapons against dangerous viruses where no specific therapy exists, as in the case of the ongoing SARS-CoV-2 pandemic. | 2020-09-14 |
| 32926870 | The COVID-19 pandemic has severely impacted Intensive Care Units (ICUs) and Critical Care Healthcare Providers (HCPs) worldwide. | 2020-09-14 |
| 32926917 | In the absence of effective antiviral therapy and vaccine, treatment of COVID-19 is largely symptomatic. […] An attractive strategy in SARS-CoV-2 therapeutics would be to augment ACE2 either directly by supplementation or indirectly through drugs which increase its levels or stimulate its downstream players. | 2020-09-14 |
| 32926918 | Substantial knowledge has been generated about the pathophysiology of the disease and possible treatment modalities in a relatively short span of time. […] As of August 19, 2020, there is no approved drug for the treatment of COVID-19. […] More than 600 clinical trials for potential therapeutics are underway and the results are expected soon. […] Based on early experience, different treatment such as anti-viral drugs (remdesivir, favipiravir, lopinavir/ritonavir), corticosteroids (methylprednisolone, dexamethasone) or convalescent plasma therapy are recommended in addition to supportive care and symptomatic therapy. | 2020-09-14 |
| 32926920 | Until now, no licensed immunization or drugs are present for the medication of SARS-CoV-2. | 2020-09-14 |
| 32926977 | After propensity matching, likelihood of hospitalization and mortality were not significantly different between the treatment and non-treatment group (risk ratio 0.91, 95% confidence interval [CI] 0.68-1.22, p=0.5260; risk ratio 0.87, 95% CI 0.42-1.78, p=0.6958, respectively). | 2020-09-14 |
| 32927092 | To evaluate the efficacy and safety of a new treatment for COVID-19 vs. standard care, certain key endpoints are related to the duration of a specific event, such as hospitalization, ICU stay, or receipt of supplemental oxygen. […] However, since patients may die in the hospital during study follow-up, using, for example, the duration of hospitalization to assess treatment efficacy can be misleading. […] If the treatment tends to prolong patients’ survival compared with standard care, patients in the new treatment group may spend more time in hospital. […] This can lead to a “survival bias” issue, where a treatment that is effective for preventing death appears to prolong an undesirable outcome. […] For the analysis of ICU stay or oxygen usage, where the initiating event is potentially an outcome of treatment, standard survival analysis techniques may not be appropriate. | 2020-09-14 |
| 32927129 | Considering its popular and important role as an antiviral drug, it is necessary to evaluate oseltamivir in the treatment of COVID-19. […] We consider that oseltamivir isn’t suitable for the treatment of COVID-19. | 2020-09-14 |
| 32927329 | With a higher risk for severe COVID-19 disease in infants, need of high-dose hormonal therapy with a concern of consequent severe disease, presence of comorbidities, and a need for frequent investigations and follow-up; children with West syndrome constitute a distinctive group with special concerns. | 2020-09-14 |
| 32927419 | Moreover, currently available microsampling applications of interest for SARS-CoV-2 therapy are described, in order to make them as much widely known as possible, hopefully providing useful information to researchers and clinicians alike. | 2020-09-14 |
| 32927583 | Our study provides the mechanism for spread of infectious aerosols, and possibly of COVID-19 infection, by air conditioning systems and also highlights important recommendations for disease control and optimization of ventilation in intensive care units, by increasing the use of outdoor air and the rate of air change, decreasing the recirculation of air and using high-efficiency particulate air (HEPA) filters. | 2020-09-15 |
| 32927735 | Without causal treatment, identification of modifiable prognostic factors may help to improve outcomes. | 2020-09-15 |
| 32927798 | Asymptomatic or mildly symptomatic COVID-19 patients who had been diagnosed with the disease at least two weeks previously and admitted to a community treatment center (CTC) from 15 March to 10 April 2020 were enrolled in this study. | 2020-09-15 |
| 32927871 | While some preventive and risk factors have been previously identified in a non-pandemic context, knowledge and cognitions on COVID-19 transmission, treatment, prognosis and prevention negatively correlate with anxiety, emerging as a key preventive factor that may provide a rationale for why the levels of anxiety have remained stable in medical students during the pandemic while increasing in their non-medical peers and the general population. | 2020-09-15 |
| 32928157 | At ICU admission the patient had fever and severe acute respiratory failure requiring high flow oxygen therapy. | 2020-09-15 |
| 32928313 | Patients who are being treated with any form of oral or parenteral antiviral therapy will be excluded, as well as patients with known pre-existing chronic mucosal lesions such as lichen planus. | 2020-09-15 |
| 32928412 | SARS -CoV-2 has a faster rate of transmission than other coronaviruses such as SARS and MERS and until now there are no approved specific drugs or vaccines for treatment. | 2020-09-15 |
| 32928672 | This systematic review highlighted two main points that may help clinicians dealing with IBD in reassuring their patients: (1) patients with IBD do not seem to be at higher risk of being infected by SARS-COV-2 than the general population; (2) in case of Covid-19, treatment with immunomodulators or biologics is not associated with worse prognosis, while systemic steroids are suspected to be potentially detrimental, even if more data are needed to confirm this point. | 2020-09-15 |
| 32928810 | Patient underwent treatment with milrinone and methylprednisolone that showed reduction in myocardial inflammation and significantly improved myocardial contractility. | 2020-09-15 |
| 32928835 | The patient improved after immunoglobulin treatment. | 2020-09-15 |
| 32928837 | To our knowledge, he is the youngest reported case in the UK to require mechanical ventilation and intensive care treatment as a direct result of COVID-19 following horizontal transmission. | 2020-09-15 |
| 32928903 | We briefly detail specific treatment strategies from a GI disease standpoint and mention special considerations when there is involvement of the GI tract. | 2020-09-15 |
| 32929000 | Furthermore, guide RNAs are essential components of novel gene editing modalities, and mRNA therapeutics are under development for protein replacement therapy or vaccination, including those against unprecedented severe acute respiratory syndrome coronavirus pandemic. […] SIGNIFICANCE STATEMENT: With the understanding of RNA functions and critical roles in diseases, as well as the development of RNA-related technologies, there is growing interest in developing novel RNA-based therapeutics. | 2020-09-15 |
| 32929302 | In this review, we summarize the relevant information about the origin and spread of SARS-CoV-2, its epidemiology and diagnostics, and the clinical course and treatment of COVID-19. | 2020-09-15 |
| 32929317 | Now, intensive work is underway about the pathogenic mechanisms and epidemiological properties of COVID-19, and a great effort is made to develop effective specific therapeutic drugs, vaccines, and/or treatment strategies against these diseases. […] Herein, we have focused on all treatment options available against COVID-19 pneumonia in this text. | 2020-09-15 |
| 32929402 | Epidemiological, demographic, clinical, chest computed tomography (CT) scan, laboratory, treatment, and outcome data from patient records were analyzed retrospectively. | 2020-09-15 |
| 32929411 | Since there is no effective medication yet, to minimize and control the transmission of the COVID-19, non-pharmaceutical interventions (NPIs) are followed globally. | 2020-09-15 |
| 32929412 | At present, there is no known effective treatment or vaccine that can mitigate/inhibit SARS-CoV-2. […] Thus, there is an exigent need for effective and non-invasive treatment. […] These mechanisms of action of SARS-CoV-2 can be mitigated by a combination therapy of medicinal herbs based on their pharmacological activities. […] Since the clinical manifestations of COVID-19 are multifactorial with co-morbidities, we strongly recommend the use of combined therapy such that two or more herbs with specific therapeutic actions are administered to combat the mediators of the disease. | 2020-09-15 |
| 32929416 | Patients in stage I and II revealed having less fear about disease progression (14 [18.18%] and four [14.81%], respectively), had lower proportions of delayed medical arrangement (15 [19.48%] and six [22.22%], respectively), and complained less about complex treatment procedures (12 [15.58%] and five [18.52%], respectively). […] The treatment of patients with lung cancer has been affected by the pandemic to some extent. […] We provide suggestions on both clinical diagnosis and treatment strategies for lung cancer to optimize the process, given the urgency of the current circumstances. | 2020-09-15 |
| 32929476 | Worldwide, thionamides are the favored treatment (12-18 months) of newly diagnosed GD, with methimazole (MMI) as the preferred drug. […] Patients with persistently high TSH-R-Abs and/or persistent hyperthyroidism at 18 months, or with a relapse after completing a course of MMI, can opt for a definitive therapy with radioactive iodine (RAI) or total thyroidectomy (TX). […] Recently, a promising therapy with an anti-insulin-like growth factor-1 monoclonal antibody for patients with active/severe GO was approved by the Food and Drug Administration. […] If GO is not severe, systemic steroid treatment should be postponed during COVID-19 while local treatment and preventive measures are offered. […] A clear trend towards serological diagnosis and medical treatment of GD has emerged. | 2020-09-15 |
| 32929539 | The palliative care program at the Princess Margaret Cancer Centre, Toronto, Canada, provides comprehensive care to patients with advanced cancer and their families, through services including an acute palliative care unit, an inpatient consultation service, and an ambulatory palliative care clinic. […] In the face of a global pandemic, palliative care teams are uniquely placed to support patients with cancer who also have COVID-19. […] In tandem, there is a need for palliative care teams to continue to provide care to patients with advanced cancer who are COVID-negative but who are at higher risk of infection and adverse outcomes related to COVID-19. […] This paper highlights the unique challenges faced by a palliative care team in terms of scaling up services in response to a global pandemic while simultaneously providing ongoing support to their patients with advanced cancer at a tertiary cancer center. | 2020-09-15 |
| 32929715 | Invasive mechanical ventilation was used in 82%, vasopressors in 83%, renal replacement therapy in 26%, and extra corporeal membrane oxygenation in 8%. | 2020-09-15 |
| 32929726 | Liquid biopsy markers undoubtedly have the potential to influence disease management and treatment dynamics. […] We believe that the noninvasive capabilities of these technologies have great potential in the development of diagnostics and can influence treatment options, thereby advancing precision disease management. | 2020-09-15 |
| 32929826 | We analysed 70 COVID-19 cases combined with HBV infection (CHI) to determine the epidemiological, clinical characteristics, treatment and outcome. | 2020-09-15 |
| 32929975 | The aminoquinolones, hydroxychloroquine, and chloroquine are undergoing evaluation as a potential therapy against COVID -19. […] As palliative care specialists encounter more COVID positive patients, palliative care specialists need to know how these drugs work, and importantly how they interact with palliative care drugs used for symptom control. […] The goals of this paper are to identify whether or not hydroxychloroquine/chloroquine improves symptoms in palliative care patients and whether or not these drugs are safe to use in the advanced illness population who have COVID. | 2020-09-15 |
| 32930052 | These findings have important implications for those pursuing plasma therapy, isolation of neutralizing monoclonal antibodies, and determinants of immunity. | 2020-09-15 |
| 32930058 | LDN may be considered as a target as the treatment and (or) adjuvant therapy for coronavirus infection. | 2020-09-15 |
| 32930394 | Eosinophilic infiltrate was also seen, probably reactive to pharmacological treatment. | 2020-09-15 |
| 32930456 | Understanding of the immune response and biomarker analysis is needed to progress toward understanding disease pathology and developing improved treatment options. | 2020-09-15 |
| 32930523 | In the struggle to devise potentially useful therapeutics in record time, the repurposing of existing compounds is a key route of action. […] In this hypothesis paper, we argue that the bisbenzylisoquinoline and calcium channel blocker tetrandrine, originally extracted from the plant Stephania tetrandra and utilized in traditional Chinese medicine, may have potential in the treatment of COVID-19 and should be further investigated. | 2020-09-15 |
| 32930657 | As a result of in vitro evidence suggesting zinc sulphate may be efficacious against COVID-19, our hospitals began using zinc sulphate as add-on therapy to hydroxychloroquine and azithromycin.Aim. | 2020-09-15 |
| 32930863 | The very rapid spread of the infection throughout all inhabited continents leads to a fast-growing number of infected with SARS-CoV-2 and requires answers and special recommendations to the most vulnerable group of people: pregnant woman and patients on immunomodulatory or immunosuppressive treatment. […] Although the World Health Organization recently reported that pregnant patients do not have a higher risk of infection than the rest of the population, Royal College of Obstetricians & Gynecologists and The Royal College of Midwives for COVID-19 infection in pregnancy published Guidelines for pregnant women with suspected SARS-CoV-2 infection.Considerations about patients with rheumatic diseases on the immunosuppressive treatment required European League Against Rheumatism, American College of Rheumatology, British Society for Rheumatology, and Australian Rheumatology Association to publish recommendations for patients with rheumatic diseases and COVID-19. | 2020-09-15 |
| 32930887 | Metabolic surgery has been studied in the last decades as an effective and safe treatment for type 2 diabetes (T2D), and randomized controlled trials generally found surgery superior when compared with medical treatment. […] In 2016, the DSS-II Joint Statement recognized the importance of metabolic surgery in the treatment of T2D and urged clinicians to discuss, recommend, or at least consider this procedure for their patients. | 2020-09-15 |
| 32930963 | A rationalisation of resources and a specific treatment path were necessary. | 2020-09-15 |
| 32931069 | To investigate the results of LU in severe and critical patients with coronavirus disease 2019 (COVID-19), we performed a single-institution study to evaluate the related lung lesions and variations, and prophylactic strategies, in a large referral and treatment center. […] Our findings support the use of LU and measurements for estimating factors, and monitoring response to therapy in severe and critical COVID-19 patients. | 2020-09-15 |
| 32931341 | Dialectical Behavioural Therapy (DBT) is an evidence-based treatment for borderline personality disorder and other problems associated with emotional dysregulation. […] It has traditionally been deployed as a face-to-face programme comprised of attendance at group skills training, individual therapy and phone coaching. […] Movement to online platforms of delivery poses problems, as some people do not have the access to internet or privacy in their home environments to engage in online therapy. | 2020-09-15 |
| 32931348 | These patients, therefore, require specific advice regarding isolation and changes to their usual treatment schedules. […] Their disease can also be associated with significant burden, and they necessitate life-long and regular access to therapy, and regular follow-up consultations and hospital visits. […] International efforts must be made to continue reporting and better understanding the effects of SARS-CoV-2 infection in these patients and accordingly develop a set of recommendations to optimize the treatment of future infected patients. | 2020-09-15 |
| 32931378 | We evaluated the systems’ authentication protocols used by pharmacies to verify patients’ identities during the medication dispensing process. […] Furthermore, we examined the supporting systems/services used to manage patients’ medication histories and enhance patients’ medication safety. | 2020-09-15 |
| 32931440 | This has implications for future practical directions, as frontline workers may begin to seek mental health treatment related to the pandemic. | 2020-09-15 |
| 32931443 | Efficient diagnosis and treatment are crucial to combat the disease. […] Computer-interpretable guidelines (CIGs) can aid the broad global adoption of evidence-based diagnosis and treatment knowledge. […] A CIG for COVID-19 was developed by translating, interpreting, annotating, extracting, and formalizing the Chinese COVID-19 diagnosis and treatment guideline. […] We developed 18 GDL rules to cover the diagnosis and treatment suggestion algorithms in the narrative guideline. | 2020-09-15 |
| 32931510 | Primary surgical treatment of urolithiasis and benign prostate syndrome (BPS) but also of testicular and penile cancer dropped by at least 50% while the decrease of surgeries for prostate, renal and urothelial cancer (TUR-B and cystectomies) ranged from 15 to 37%. | 2020-09-15 |
| 32931622 | In the natural history of SARS-CoV-2 infection, liver injury is frequent but quite mild and it is defined as any liver damage occurring during disease progression and treatment of infection in patients with or without pre-existing liver diseases. | 2020-09-15 |
| 32931666 | Patients in this trial received hyperbaric oxygen therapy at 2.0 atmospheres of pressure in monoplace hyperbaric chambers for 90 minutes daily for a maximum of five total treatments. | 2020-09-15 |
| 32931727 | No children required ventilation, antiviral therapy or underwent thoracic computed tomography scan. | 2020-09-15 |
| 32931782 | Particularly, effective drugs are still lacking in the COVID-19 therapy. […] In this review, we find and summarize the effectiveness of magnesium supplementation on the disorders or diseases, and provide a reference to the possibility of magnesium supplementation for supportive treatment in patients with COVID-19. | 2020-09-15 |
| 32931783 | The severity of the recent pandemic and the absence of any specific medication impelled the identification of existing drugs with potential in the treatment of Coronavirus disease-2019 (COVID-19), caused by severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2). | 2020-09-15 |
| 32931811 | Twenty-six (37%) patients expressed interest in DMPA-SC and scheduled telehealth appointments to learn to self-administer the medication. | 2020-09-15 |
| 32931823 | Thus, etoposide may have a role as salvage therapy in treatment of cytokine storm in COVID-19. | 2020-09-15 |
| 32931985 | This scoping review identified that some medication classes may confer increased risk of acute respiratory viral infections. | 2020-09-15 |
| 32932252 | To investigate whether patients with hematologic diseases undergoing therapy are at increased risk for acquiring SARS CoV-2 infection compared to the general population, a retrospective study was carried out at a referral hematologic center in Rome, Italy, during the period of the greatest epidemic spread (March 8 to May 14, 2020). […] All adult and pediatric patients with a diagnosis of a neoplastic or a nonneoplastic hematologic disease who underwent treatment (chemotherapy or immunosuppressive or supportive therapy) during the study period or in the previous 6 months were considered. […] The prevalence of COVID-19 in the overall outpatient and inpatient population undergoing hematologic treatment compared to that of the general population was analyzed. | 2020-09-15 |
| 32932329 | This prospective multicentered cohort study included 24 neonatal intensive care units around Turkey, wherein outpatient neonates with COVID-19 were registered in an online national database. | 2020-09-15 |
| 32932534 | The objective of this study was to review the origin and characteristics of this virus (SARS-CoV-2), symptoms and diagnosis of COVID-19, treatment of people with COVID-19, forms of transmission of the SARS-CoV-2, and precautions in dentistry. […] SARS-CoV-2 articles about the origin and characteristics of this virus (SARS-CoV-2), symptoms and diagnosis of COVID-19, treatment of people with COVID-19, forms of transmission of the SARS-CoV-2, and precautions in dentistry were included. | 2020-09-15 |
| 32932582 | This indicates that the impact of COVID-19 on patients’ daily lives is tremendous, and more attention is needed to identify optimal treatment strategies to restore patients’ independency. | 2020-09-16 |
| 32932612 | Five patients required ICU treatment, four of whom were aged >10 years, two presented with acute myocarditis, and two were sickle cell disease patients who presented with acute chest syndrome. […] Discussion and conclusion: The youngest patients seem to present milder forms of COVID-19 without the need for ICU treatment and with a shorter length of hospitalization. | 2020-09-16 |
| 32932831 | PTH concentrations were increased in patients who needed intensive care unit (ICU) treatment, while VITD levels were not significantly different between disease severity groups. | 2020-09-16 |
| 32932930 | Building on the results of the Randomized Evaluation of COVID-19 Therapy (RECOVERY) trial demonstrating the benefit of low dose dexamethasone in COVID-19, repurposed drugs targeting inflammation are promising. | 2020-09-16 |
| 32932951 | The main COVID-19 symptoms included benign upper respiratory infection signs (N = 9, 81.8%), diarrhea (N = 7, 63.6%), fatigue (N = 7, 63.6%), and respiratory signs (N = 5, 45.5%), including one patient who needed oxygen therapy. | 2020-09-16 |
| 32933172 | Our study demonstrates that performing screening tests as early as possible to facilitate the rapid detection of infected cases, fast treatment, and instant isolation for suspected cases is the most definitive rejoinder for public health. | 2020-09-16 |
| 32933365 | An extended literature survey was performed investigating the pharmacokinetics, the efficacy and safety of HCQ in COVID-19 treatment. […] Based on the results from simulations performed and the currently published knowledge regarding HCQ in COVID-19 treatment, this study provides evidence that a high loading dose followed by sparse doses could offer significant benefits to the patients. | 2020-09-16 |
| 32933378 | Interruption of viral replication by drugs proposed in this study should be further tested to pave the way for in vivo studies towards the treatment of COVID-19. | 2020-09-16 |
| 32933536 | The increasing number of COVID-19 cases around the world is overwhelming hospitals and pushing the global death toll to over 746,000, which has pushed the sprint to find new treatment options. […] In this article, we reviewed the SARS-CoV-2 pathophysiology, transmission, and potential treatment strategies. | 2020-09-16 |
| 32933552 | Both male and female patients with ≥18 years of age (≥ 35 kg of weight), admitted at the Shahid Mohammadi Hospital, Hormozgan University of Medical Sciences, Bandar Abbas for treatment, screened for the following criteria. […] Signing informed consent and willingness of study participant to accept randomization to any assigned treatment arm. […] Treatment with Investigational and antiviral therapy in a clinical study within one month before randomization. […] Intervention group: The standard treatment regimen for COVID-19 along with a Licorice-based herbal preparation (D-Reglis ®, Irandarouk Pharmaceutical Company, Iran) at a dose of 760 mg three times a day for a period of seven days. […] The standard treatment for COVID-19 based on the Iranian Ministry of Health and Medical Education’s protocol for a period of seven days. | 2020-09-16 |
| 32933835 | According to the World Health Organization International Clinical Trials Registry Platform and the National Institutes of Health ClinicalTrials.gov databases, 27 clinical investigations of MSC-based cell therapy approaches have begun in China since the onset of the COVID-19 outbreak, with a growing number of academic and industry trials elsewhere as well. […] Therefore, although there may be a potential role for MSCs and other cell-based therapies in treatment of COVID-19, these need to be investigated in a rationally designed, controlled approach if safety and efficacy are to be demonstrated accurately. | 2020-09-16 |
| 32933891 | Treatment with tocilizumab, a monoclonal antibody directed against the interleukin-6 (IL-6) receptor, was shown to lead to clinical improvement in patients with severe COVID-19. | 2020-09-16 |
| 32933914 | We present a case of a 50-year-old man with COVID-19 infection and acute respiratory distress syndrome as a result of a cytokine storm and use of anakinra, an interleukin 1-receptor antagonist that is normally used in the treatment of autoinflammatory disorders in adult patients. | 2020-09-16 |
| 32933915 | Romiplostim and eltrombopag were given and after 9 weeks of treatment, his platelet count normalised. | 2020-09-16 |
| 32934084 | Viral nuclear import was significantly reduced, and this deficit was substantially rescued by cyclosporine treatment. | 2020-09-16 |
| 32934372 | Virus-specific antibodies from recovered persons are often the first available therapy for an emerging infectious disease, a stopgap treatment while new antivirals and vaccines are being developed1,2. […] This retrospective, propensity score-matched case-control study assessed the effectiveness of convalescent plasma therapy in 39 patients with severe or life-threatening COVID-19 at The Mount Sinai Hospital in New York City. | 2020-09-16 |
| 32934420 | Those patients who had absolute indications for surgery were offered surgery, while conservative treatment was more favored in those with relative indications. | 2020-09-16 |
| 32934633 | Necessary procedures during the COVID-19 pandemic include electroconvulsive therapy (ECT). […] This article attempts to describe such a framework for ECT procedures acknowledging limited solid scientific evidence at this time and being mindful of future changes to these suggestions as testing, immunization, and treatment options develop. | 2020-09-16 |
| 32934678 | Rapid and accurate molecular diagnostic technologies are crucial for the screening, isolation, treatment, prevention and control of COVID-19. […] The most effective way to prevent and control COVID-19 is early detection, diagnosis, isolation and treatment. | 2020-09-16 |
| 32934770 | This therapeutic modality would not a-priori interfere directly with current efforts toward the immunological targeting of the RBD epitope; hence, it could be exploited as a complementary treatment. | 2020-09-16 |
| 32934806 | However, there still lacks efficient treatment for COVID-19 induced lung injury and acute respiratory failure. […] Conclusions: This study shows that ACE2 inhibition is likely part of the mechanisms leading to lung injury in COVID-19, and that compounds such as COL-3 and CGP-60474 have potential as repurposed drugs for its treatment. | 2020-09-17 |
| 32934940 | Conclusion: This study highlighted the focused subjects on various aspects of COVID-19 literature such as pathogenesis, epidemiology, transmission, diagnosis, treatment, prevention, and its complications. | 2020-09-16 |
| 32935064 | In this review, we re-evaluated the treatment outcomes and current hypothesis for the working mechanisms of CQ/HCQ as COVID-19 therapy with a special focus on disruption of Ca2+ signaling. […] We propose that intracellular calcium homeostasis is an alternative mechanism for CQ/HCQ pharmacology, which should be considered when evaluating the risks and benefits of therapy in these patients and other perspective applications. | 2020-09-16 |
| 32935079 | With many drugs being tried in the management and treatment of COVID-19, dupilumab is one such monoclonal antibody that has come under the limelight for its possible role as an adjunct therapy in COVID-19 position. […] There are isolated case reports and series that document a milder course of COVID-19 infection in patients who have already been on dupilumab therapy for treatment of conditions such as atopic dermatitis and chronic rhino-sinusitis with nasal polyp. | 2020-09-16 |
| 32935083 | Among the respondents, 56% reported using immunomodulatory treatment for all MIS-C patients, regardless of presentation. […] There is variation in management of MIS-C patients with suboptimal evidence to assess superiority of the various treatments; evidence-based gaps in knowledge should be addressed through worldwide collaboration to optimize treatment strategies. | 2020-09-16 |
| 32935406 | The aim of the study was to evaluate the impact of COVID-19 on patients and caregivers of IBD patients regarding their concerns and worries related to own health, access to treatment and availability of factor concentrates and their experiences related to medical care. […] One quarter worried (very) strongly about getting the coronavirus, 71.3% asked themselves what will happen to them when they will get COVID-19, 40.1% felt unchanged, and 18.9% worried about delivery difficulties of their IBD treatment product. […] Haemophilia specialists should be committed to address these concerns and guarantee treatment despite containment strategies. | 2020-09-16 |
| 32935435 | Intravenous (IV) infusion of insulin remains the treatment of choice for treating DKA; however, the policy of many hospitals around the world requires admission to an intensive care unit (ICU) for IV insulin infusion. […] Specifically, this guideline summarizes evidence for the role of subcutaneous insulin in treatment of uncomplicated mild to moderate DKA in young people and may be implemented if administration of IV insulin is not an option. | 2020-09-16 |
| 32935610 | Patient could not tolerate the supine position even briefly and required a central venous catheter insertion for continuous renal replacement therapy. | 2020-09-16 |
| 32935613 | Team members included employees deployed from diverse departments such as Physical and Occupational Therapy, Nursing Education, Hospital Operations, and Advance Practice Providers. | 2020-09-16 |
| 32935628 | We retrospectively reviewed real-time reverse transcriptase-polymerase chain reaction (RT-PCR) test results of mild or asymptomatic COVID-19 patients who were admitted at the Daegu-Gyeongbuk 7th community treatment centre in Korea between 9 March 2020 and 10 April 2020. | 2020-09-16 |
| 32935814 | The treatment is, in essence, supportive. | 2020-09-16 |
| 32935831 | The arbitrarily primed polymerase chain reaction (AP-PCR) improvement of viral RNA integrity was supported by (a) the AP increased resistance of the targeted gene (N gene) of SARS-CoV-2 RNA to RNase treatment; (b) the detection of SARS-CoV-2 RNA by AP-PCR with lower cycle threshold values (-2.7 cycles) compared to two commercially available assays; (c) improvement of the viral RNA stability of the ORF gene upon targeting of the N gene and RNase. | 2020-09-16 |
| 32935872 | The transfer of passive immunity with convalescent plasma is a promising strategy for treatment and prevention of COVID-19, but donors with a history of nonsevere disease are serologically heterogenous. | 2020-09-16 |
| 32935877 | Coronavirus disease 2019 (COVID-19) convalescent plasma (CCP) collection began in two Brazilian hospitals for treatment of severe/critical patients. | 2020-09-16 |
| 32935928 | In this systematic review, the available evidence for the crosstalk between COVID-19 and CVD and its treatment was analysed. […] Clinicians need to pay close attention to cardiovascular complications during the diagnosis and treatment of patients with COVID-19 to reduce patient mortality. | 2020-09-16 |
| 32936034 | We sought to summarize the limited body of literature regarding PM in patients with COVID-19 and characterize the presentation and clinical outcomes of PM in patients with severe acute respiratory syndrome (SARS)-COV-2 pneumonia at our institution to better define the incidence, prognosis, and available treatment for this condition. | 2020-09-16 |
| 32936044 | Background: Palliative care seeks to support the physical, psycho-social and spiritual needs of patients and families who are facing life threatening diseases. […] Advantages of establishing a palliative care unit, or alternatively co-locating patients, include promoting optimal physical and psychological symptom management; increased family satisfaction; and facilitating resource allocation. […] Result/Implementation: Using previously identified key focused action categories as framework, we describe our successful palliative care unit (PCU) conversion into a COVID-19 care unit. | 2020-09-16 |
| 32936048 | These data contribute to a better understanding of the mechanism of infection of SARS-CoV-2 to T lymphocytes and could provide valuable insights for the rational design of adjuvant treatment for COVID-19. | 2020-09-16 |
| 32936214 | This cohort study enrolled all inpatients with COVID-19 in Suizhou Zengdu Hospital, Suizhou, China, a designated hospital for COVID-19 treatment in the area, from January 27 to March 13, 2020. | 2020-09-16 |
| 32936252 | Administration of hydroxychloroquine with or without azithromycin for the treatment of coronavirus disease 2019 (COVID-19)-associated pneumonia carries increased risk of corrected QT (QTc) prolongation and cardiac arrhythmias. […] In this cohort study, patients who received hydroxychloroquine for the treatment of pneumonia associated with COVID-19 were at high risk of QTc prolongation, and concurrent treatment with azithromycin was associated with greater changes in QTc. […] Clinicians should carefully weigh risks and benefits if considering hydroxychloroquine and azithromycin, with close monitoring of QTc and concomitant medication usage. | 2020-09-16 |
| 32936273 | There have been recommendations to discontinue these medications, which are essential in the treatment of several chronic disease conditions, while, in the absence of clinical evidence, professional societies have advocated their continued use. […] However, further study in larger numbers of hospitalized patients receiving ACEI and ARB therapy is needed to determine the association with clinical measures of COVID-19 severity. | 2020-09-16 |
| 32936318 | Corticosteroids, anakinra, intravenous immunoglobulin (IVIG), and acetylsalicylic acid were used in the treatment. […] Three patients recovered after the treatment while one patient died. | 2020-09-16 |
| 32936348 | At the beginning of the SARS-CoV‑2 outbreak, personal protective equipment (PPE) was scarce worldwide, leading to the treatment of patients partially without sufficient protection for the medical personnel. […] The consumption of PPE needed for every patient was calculated based on the following data of the Ulm University Hospital: the total consumption of healthcare workers’ PPE for April 2020 recorded by the materials management department and the number of patients suffering from COVID-19 and their treatment days. […] From the amount of PPE necessary for every patient in the intensive care unit (ICU) or in an infection ward, a PPE calculator was created in which the estimated amount of PPE can be calculated with the input variables “patients in intensive care unit”, “patients in infection ward” and “treatment days”. | 2020-09-16 |
| 32936438 | COVID-19 is a new infectious disease causing severe respiratory failure and death for which optimal treatment is currently unclear. […] Many therapies have been proven to be ineffective; however, promising findings related to corticosteroid therapy have been published. […] Analysis of published data including in this issue suggests that therapy with corticosteroids in the range of 6 mg of dexamethasone (or equivalent) per day likely has a positive effect in patients requiring mechanical ventilation but there remains considerable doubt in patients over the age of 70, in patients with diabetes and patients with milder disease. | 2020-09-16 |
| 32936695 | In a time of crisis, continued access to and delivery of medication for opioid use disorder (M-OUD) is essential to save lives. | 2020-09-16 |
| 32936768 | Our art therapy group programming serves as an applied case study, demonstrating the value of a well-managed web-based program (eg, patients were receptive and well-engaged, and they appreciated the continuity of accessible service) as well as the challenges (eg, the need for backup plans and technological fallbacks, managing interruptions and telecommunication learning curves, and working around the difference in resources for art and music therapy between a well-stocked clinical setting versus clients’ home spaces). | 2020-09-16 |
| 32936770 | Lack of a vaccine or optimized intervention raised the importance of characterizing risk factors and symptoms for the early identification and successful treatment of patients with COVID-19. | 2020-09-16 |
| 32936948 | If a positive treatment effect is demonstrated when studies are available for inclusion in this review, it may not be large. | 2020-09-16 |
| 32936949 | If a positive treatment effect is demonstrated when studies are available for inclusion in this review, it may not be large. | 2020-09-16 |
| 32937008 | The primary outcome is a hierarchical global rank score incorporating time to death, duration of mechanical ventilation, duration of renal replacement or vasopressor therapy, and multiorgan dysfunction severity. | 2020-09-16 |
| 32937590 | The outbreak of the highly contagious and deadly severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), also known as coronavirus disease 2019 (COVID-19), has posed a serious threat to public health across the globe, calling for the development of effective diagnostic markers and therapeutics. […] Treatment with TGFBIp neutralizing antibodies suppressed the cytokine storm. | 2020-09-16 |
| 32937800 | The repurposing of colchicine for the treatment of COVID-19 was suggested based in its immunomodulatory, anti-inflammatory, and anti-viral properties. | 2020-09-17 |
| 32937946 | It continues by detailing specific strategies such as wide-spread testing, tracking, treatment and quarantine that have enabled Korea to prevent wide-spread community transmission. | 2020-09-17 |
| 32938349 | Currently, there is no standard drug or vaccine available for the treatment, so repurposing of existing drugs is the only solution. […] The role of various NDDS in repurposing of existing drugs for treatment of various viral diseases and their relevance in COVID-19 has discussed in this paper. | 2020-09-17 |
| 32938419 | These results may be useful for health care protocols for the early detection and management of patients that may benefit from opportune and specialized supportive medical treatment. | 2020-09-17 |
| 32938445 | Clinicians should be vigilant about the diagnosis and treatment of this complication. | 2020-09-17 |
| 32938496 | On the other hand, the standard of care has changed and nowadays the use of corticosteroids has become part of the SOC in the treatment of COVID-19 pneumonia. […] Our limited experience suggests that better treatment outcomes can be achieved when combining IL6-inhibitors (e.g. sarilumab) with corticosteroids. […] Patients must present elevation of inflammatory parameters (IL-6 > 40 pg/mL or d-dimer >1.0 mcg/ml) or, alternatively, progressive worsening in at least two of these inflammatory parameters in the prior 24-48h: CRP, LDH, serum ferritin, lymphopenia, or d-dimer. high oxygen requirements (including face mask with reservoir, non-invasive mechanical ventilation or high flow nasal cannula, or mechanical ventilation), admission to ICU, pregnancy or lactation, allergy or hypersensitivity to sarilumab or corticoesteroids, immunosuppressive antibody therapy within the past 5 months, AST/ALT values > 10 x ULN, neutropenia (< 0.5 x 109/L), severe thrombocytopenia (< 50 x 109/L), sepsis caused by an alternative pathogen, diverticulitis with risk of perforation or ongoing infectious dermatitis. […] Clinical follow-up visits will be performed at 3, 5, and 15 days after treatment randomization. […] Patients randomly assigned to sarilumab therapy at baseline progressing to Brescia-COVID 2-3 will be rescued according to local clinical practice protocols. […] A final follow-up visit will be conducted for all patients at day 29 from randomization, regardless of initial treatment assignment. […] The target sample size will be 200 COVID-19 patients, who will be allocated randomly to control arm (100) and treatment arm (100). | 2020-09-17 |
| 32938545 | Is it possible to develop a reliable, safe treatment for the widespread COVID-19 pandemic shortly? […] In presence of the cytokine storm, especially in severe patients, antagomiRs, already demonstrated to be efficient and secure in cardiovascular disease, could represent a useful alternative to such treatment, customizable upon the disease specificities and applicable to other coronaviruses possibly associated with such clinical manifestations, while a reliable, efficient vaccine is being distributed. | 2020-09-17 |
| 32938761 | In Vero E6 and in Calu3 cells, SARS-CoV-2 is substantially attenuated in the context of IFN-I pretreatment, while SARS-CoV is not. […] Comparing SARS-CoV-2 and influenza A virus in human airway epithelial cultures (HAEC), we observe the absence of IFN-I stimulation by SARS-CoV-2 alone, but detect failure to counteract STAT1 phosphorylation upon IFN-I pretreatment resulting in near ablation of SARS-CoV-2 infection. […] Next, we evaluated IFN-I treatment post infection and found SARS-CoV-2 was sensitive even after establishing infection. […] Together, the results identify key differences in susceptibility to IFN-I responses between SARS-CoV and SARS-CoV-2 that may help inform disease progression, treatment options, and animal model development.IMPORTANCE With the ongoing outbreak of COVID-19, differences between SARS-CoV-2 and the original SARS-CoV could be leveraged to inform disease progression and eventual treatment options. | 2020-09-17 |
| 32938838 | Since the identification of critical patients is crucial for developing effective management strategies, we evaluated clinical characteristics, laboratory data, treatment provided, and oxygenation to identify potential predictors of mortality among critical COVID-19 pneumonia patients. […] During the first week after tracheal intubation, non-survivors displayed lower values for minimum ratio of the partial pressure of oxygen to fractional inspiratory oxygen concentration (P/F ratio) (44 mmHg vs. 122 mmHg, p < 0.01) and poor response to intensive therapy compared with survivors. | 2020-09-17 |
| 32938937 | To date, there is no treatment for coronavirus infections, making the development of therapies to prevent future epidemics of paramount importance. […] This dataset will help accelerate the design of therapeutics against SARS-CoV-2, as well as contribute to prevention of possible future coronaviruses outbreaks. | 2020-09-17 |
| 32939109 | The recommended indications for treatment of various medical conditions, medical procedures, and protocols have regressed on the evolutionary timeline. | 2020-09-17 |
| 32939273 | This work builds foundations for future structure-based research on ADRP, including the search for potential antiviral therapeutics. | 2020-09-17 |
| 32939324 | While protective humoral and cellular immune responses are usually mounted against these betacoronaviruses, immune responses to SARS-CoV2 sometimes derail towards inflammatory tissue damage, leading to rapid admissions to intensive care units. […] The lack of knowledge on mechanisms that tilt the balance between these two opposite outcomes poses major threats to many ongoing clinical trials dealing with immunostimulatory or immunoregulatory therapeutics. | 2020-09-17 |
| 32939662 | ART treatment being classified as non-essential has only recently re-started, facing new challenges while enabling pregnancy at a time of uncertainty. […] When pursuing pregnancy through IVF treatment during the pandemic, distancing and caution have the lead role in an effort to defend the health of the intended parents and future children. […] To promote patient autonomy along with our ethical, moral, and legal duty towards our patients, emphasis should be given on ascertaining shared decision-making, and ensuring that an appropriate all-inclusive informed consent is signed prior to initiating any IVF treatment. | 2020-09-17 |
| 32939794 | Surgical treatment was reserved only to symptomatic, urgent, or emergent cases. | 2020-09-17 |
| 32939844 | The findings from thematic analysis suggested several psychosocial negative impacts and impacts on disease and treatment-related health behaviors (eg, difficulties managing dietary restrictions during the lockdown and diminished physical activity), which can partially explain these quantitative results. | 2020-09-17 |
| 32939853 | Treatment for the haematological disease was ongoing in 59.1% of cases. […] Mortality was highest in older patients, patients with severe/critical SARS-CoV-2 infection, high comorbidity score or high performance status score, purine analogue treatment and with AL/MDS. | 2020-09-17 |
| 32939917 | Seventy-four per cent of parents reported that their child lost access to at least one therapy or education service, and 36% of respondents lost access to a healthcare provider. | 2020-09-17 |
| 32940059 | Conclusion Our experience managing patients with prostate cancer during the COVID-19 pandemic showed that changing the office routine, stratifying the patients according to the NCCN risk, and adopting COVID-based criteria to select patients for surgery are necessary actions to maintain the best quality of treatment and minimize the viral infection among our oncological patients. | 2020-09-17 |
| 32940123 | Beginning with the index case, we describe the sequential order of procedures undertaken by the facility including testing, infection control, treatment, and communication with facility residents, staff, and family members. | 2020-09-17 |
| 32940180 | Until today, the best solution for the moment remains prevention (Social distancing, hand disinfection, use of masks, partial or total sanitary containment, etc.), there is also the emergence of drug treatment (research and development, clinical trials, use on patients). […] This review aims to summarize the state of the art of research concerning the use of cyclodextrin or its complexes as a potential treatment against this new virus and update work already published. | 2020-09-17 |
| 32940187 | However there are no approved treatment for covid-19 globally. […] However we need more randomized research studies with significant number of patients which can confirm the promising results on tocilizumab treatment in covid-19 patients and even ongoing clinical trails such as TOSCA, COVACTA results has not been published yet which are expected to give better and more significant results on tocilizumab’s effectiveness and safety. | 2020-09-17 |
| 32940188 | The diagnosis, follow-up, and treatment methods of IIH during the COVID-19 pandemic period are reviewed. […] When surgical treatment is indicated, optic nerve sheath fenestration may be the primary procedure of choice during the pandemic period. | 2020-09-17 |
| 32940326 | Because people living with HIV commonly experience mistreatment associated with HIV, their response to social distancing may be complicated by psychosocial attitudes associated with COVID-19. | 2020-09-17 |
| 32940425 | In advanced stage endometrial cancer cases, 28.8% had postponed any treatment and 28.8% administered chemotherapy. […] In early stage cervical cancer, surgical treatment was provided in 46.5% centers. […] COVID-19 has affected the treatment of gynecologic cancers patients and health care professionals are trying to mitigate the damage by incorporating new elements which are suited to the current scenario. | 2020-09-17 |
| 32940656 | The primary study outcome measurement was the log reduction value after 15 seconds and 30 seconds of given treatment. | 2020-09-17 |
| 32940702 | In this topical review, we describe how we used treatment fidelity as a guiding principle to orient adaptations for telepsychology, as well as preliminary findings and early lessons learned in this implementation. […] Caregivers completed measures on demographics, treatment satisfaction, and telepsychology experience. […] Telepsychology BC-ADHD can be implemented with comparably high levels of content and process fidelity and treatment satisfaction to in-person groups; and it appears to be feasible and acceptable to caregivers. […] When treatment fidelity is used as a guiding tool, telepsychology parent training groups can be delivered with high fidelity and appear to be acceptable and feasible to caregivers and clinicians. | 2020-09-17 |
| 32940880 | Favipiravir, an antiviral agent developed for treatment of influenza, is one candidate treatment for COVID-19, but suitable dosages for patients with renal insufficiency are unknown. […] Favipiravir may be an effective option for the treatment of COVID-19-infected patients with ESRD. | 2020-09-17 |
| 32940963 | Questions included patients’ socio-demographics, diseases, medications, COVID-19 knowledge, source of information, fear level, disease activity perception, health care utilization, medication accessibility, and therapeutic compliance (measured using a modified version of Medication Adherence Reporting Scale). […] However, patients’ perceptions of worsened disease activity were correlated with unplanned healthcare visits (P < .001), medication non-adherence, and difficulty accessing medication (P = .010 and .006, respectively). | 2020-09-17 |
| 32941186 | Treatment with vitamin D supplements should be based on severity of the vitamin D deficiency. | 2020-09-17 |
| 32941222 | This paper aims to elucidate the medical and financial consequences driven by the measures for COVID-19 treatment in a tertiary care centre. | 2020-09-17 |
| 32941264 | Although there are numerous trials underway, there is currently no medication known to cure the infection. […] Non-steroidal anti-inflammatory drugs (NSAIDs) are inexpensive, widely available medications with antiviral and anti-inflammatory properties, and may have utility as an adjunct therapy to improve outcomes in patients with severe COVID-19 infection. […] NSAIDs may be a useful adjunct therapy for patients with severe COVID-19 infection, but further investigation and clinical trials are necessary to ensure their safety and efficacy. | 2020-09-17 |
| 32941292 | Preferences were assessed in relation to: (i) specific forms of tobacco cessation support (eg, nicotine replacement therapy (NRT) and various counseling formats); (ii) information sources (eg, government officials, doctors); and (iii) channels via which to receive relevant information (eg, television, social media). | 2020-09-17 |
| 32941351 | The impact of the diagnosis on parents is immense and the complexity of treatment now and in the future, are a challenge for both parents and teams. | 2020-09-17 |
| 32941394 | Drug-drug interactions (DDI) between immunosuppressants and COVID-19 management medication were collected. | 2020-09-17 |
| 32941437 | This is the first edition of a living systematic review of randomized clinical trials comparing the effects of all treatment interventions for participants in all age groups with COVID-19. […] Secondary outcomes were admission to intensive care, mechanical ventilation, renal replacement therapy, quality of life, and nonserious adverse events. […] Otherwise, no evidence-based treatment for COVID-19 currently exists. […] This review will continuously inform best practice in treatment and clinical research of COVID-19. | 2020-09-17 |
| 32941512 | Until treatment and vaccine for coronavirus disease-2019 (COVID-19) becomes widely available, other methods of reducing infection rates should be explored. | 2020-09-17 |
| 32941626 | The question is of particular relevance for people with immune deficiencies, as their health depends on treatment with immunoglobulin preparations that need to contain neutralizing antibodies against the pathogens in their environment. | 2020-09-17 |
| 32941641 | Adjustments were made to the physical therapy routine and protocols. | 2020-09-17 |
| 32941741 | To understand the clinical effectiveness and safety of Shufeng Jiedu Capsules combined with umifenovir (Arbidol) in the treatment of common-type COVID-19. […] A treatment regimen of Shufeng Jiedu Capsules combined with Arbidol to treat common-type COVID-19, combining traditional Chinese and western allopathic medicine, improves time to recovery, has better clinical effectiveness, and is safe. | 2020-09-17 |
| 32941783 | Our results indicate that the hexapeptide might be a possible treatment option that prevents the viral activation through the inhibition of the interaction between ACE2 and CoV-2 RBD. | 2020-09-17 |
| 32941797 | Therefore, we suggest a possible parallel program in the pulmonary stellate cells of COVID-19 patients and propose repurposing paricalcitol infusion therapy to restrain the COVID-19 cytokine storm. […] This proposed therapy could prove important to people of color who have higher COVID-19 mortality rates and lower vitamin D levels. | 2020-09-17 |
| 32941803 | Novel COVID-19 therapeutics are urgently needed. | 2020-09-17 |
| 32941862 | and Methods: In this multi-center, retrospective, observational cohort study of intensive care units in four hospitals in New Orleans, LA, we collected data on adults admitted to an intensive care unit (ICU) and tested for SARS-CoV-2 between March 9, 2020 and April 14, 2020. | 2020-09-17 |
| 32941927 | The impact of corticosteroid treatment on virological course of coronavirus disease 2019 (COVID-19) patients remains unclear. […] Of the 309 COVID-19 patients, eighty-nine (28.8%) patients received corticosteroid treatment during hospitalization. […] Corticosteroid treatment may delay the SARS-CoV-2 clearance of COVID-19 patients and should be used with cautions. | 2020-09-17 |
| 32942143 | Nucleic acid-based molecular diagnosis reveals valuable information at the genomic level about the identity of the disease-causing pathogens and their pathogenesis, which help researchers, healthcare professionals, and patients to detect the presence of pathogens, track the spread of disease, and guide treatment more efficiently. | 2020-09-17 |
| 32942152 | There are similar injury mechanisms in SARS-CoV-2 infection and neuronal injury, equally reduced by ARB treatment. | 2020-09-17 |
| 32942296 | The lack of a vaccine or any effective treatment for the aggressive novel coronavirus disease (COVID-19) has created a sense of urgency for the discovery of effective drugs. | 2020-09-17 |
| 32942311 | Given the current lack of definitive treatment or vaccine that significantly reduces mortality rate, governments, researchers and healthcare providers are racing to find possible solutions to the crisis. | 2020-09-17 |
| 32942748 | Notably, Fingolimod (FTY720), a modulator of S1P receptors, has been approved for the treatment of MS and is being tested for COVID-19. | 2020-09-18 |
| 32942785 | Chronic pain exacerbations are associated with marked functional declines and risks with alternative treatment modalities. | 2020-09-18 |
| 32942790 | Going forward, an effective treatment for COVID-19 or a safe vaccine and a deeper understanding of the pathophysiology of the virus will certainly change the risk calculus involved in performing an EBP in a COVID-19 patient. | 2020-09-18 |
| 32942791 | Regarding regenerative therapy, despite plenty of evidence in literature, we have not yet considered it as a routine therapy for chronic pain injections. […] It is now time to move on beyond steroids and consider other types of medications and treatment options.The use of these medications in clinical practice is less auspicious, and thus more research is needed on the practical applications. […] Numerous scientific studies have been conducted to investigate the genetic basis of phenotypic variability in individuals with different ethnic groups in terms of susceptibility to chronic pain, as well as response to treatment for the personalized medicine model. | 2020-09-18 |
| 32942793 | These drugs showed positive results in preliminary scientific research for treatment of the severe acute respiratory syndrome coronavirus (SARS-CoV-2). […] Clinical studies have some methodology shortcomings, such as lack of information about the treatment and small number of experimental patients, leading to a misinterpretation of the data. […] Besides, a lot of uncertainty still remains, such as starting administration period, dose prescribed, length of treatment, patients’ condition, concomitant drug use, among others. […] From the studies reviewed, it is not possible to state the precise efficacy and safety of CQ and HCQ use in the treatment of COVID-19 at any time in the course of the disease. | 2020-09-18 |
| 32942794 | For example, pill counts can be done in a video call and patients can still get questions answered about their pain therapy, although it is likely that after the crisis, prescribing controlled substances may revert to face-to-face visits. | 2020-09-18 |
| 32942796 | Unfortunately, there is no definitive or curative treatment for this condition, and the management has been predominantly confined to supportive care, which necessitates an urgent need for novel therapies. […] Mesenchymal stem cell (MSC) therapy has a vast array of preclinical data and early, preliminary clinical data that suggests its potential to regenerate and restore the function of damaged tissues and organs. […] To date, there has been no review of all the clinical trials that have assessed the safety and efficacy of MSC therapy in organ failure commonly seen in seriously complicated COVID-19 patients. […] To evaluate the effectiveness of MSC therapy in managing multiorgan failure, utilizing currently available literature. […] A review of human randomized controlled trials (RCTs) and observational studies assessing the role of MSC therapy in managing multiorgan failure. […] The secondary outcome assessed the safety of MSC therapy in the clinical trials. […] Among the 6 studies that specifically assessed the effectiveness of MSC therapy in ARDS, 4 showed positive outcomes. […] The incidence of disease worsening or major complications was extremely rare from MSC therapy. […] MSC therapy seems to be promising to treat multiorgan failure from COVID-19. | 2020-09-18 |
| 32942797 | A literature search was conducted to find published manuscripts on the treatment of ARDS and COVID-19 symptoms, disease presentation, and available treatment regimens. […] Electronic data bases of scientific articles and records of printed documents of JAMA journals were searched to find research publications on MSC treatment of ARDS and COVID-19. […] No significant differences in treatment outcome were found in randomized double-blind trials; however, results of 1 pilot study and 1 case report showed that MSCs led to lung symptom resolution and survival in severely ill treatment patients. […] MSCs are potentially life-saving treatment approaches for some patients who exhibit severe lung distress and have not responded to standard treatments. […] This is an obviously exciting research and treatment option for COVID-19 and other life-threatening diseases. | 2020-09-18 |
| 32942800 | Throughout the COVID-19 pandemic, clinicians have had to think quickly, adapt to changing recommendations sometimes on a daily basis, and have often had to rely on trial-and-error-based treatment protocols under various conditions. […] As we move on past the apex of the COVID-19 curve, new treatment protocols for the safe reintegration of elective interventional pain procedures into chronic pain practice are needed. | 2020-09-18 |
| 32942812 | The physical examination is an essential component for sound clinical judgment and patient care planning. | 2020-09-18 |
| 32942901 | Medication shortages were noted by approximately 30% of respondents, with no clear pattern in types of medication involved. | 2020-09-18 |
| 32942923 | In this report, we consolidate and review the available clinically and preclinically relevant results emanating from in vitro animal models and clinical studies of drugs approved for emergency use as a treatment for COVID-19, including remdesivir, hydroxychloroquine, and lopinavir-ritonavir combinations. | 2020-09-18 |
| 32942955 | As there is no specific treatment for COVID-19 there is considerable scientific endeavor globally to raise a safe and effective vaccine against SARS-CoV-2, in addition to engineering neutralizing antibody interventions. | 2020-09-18 |
| 32943115 | This exclusion category comprises: a) subjects with known infection by the human immunodeficiency virus (HIV-1) b) subjects with solid organ transplantation c) subjects with bone marrow transplantation d) subjects under chemotherapy e) subjects with primary immunodeficiency f) subjects under treatment with any anti-cytokine therapy within the last year g) subjects under treatment with oral or intravenous steroids defined as daily doses of 10 mg prednisone or equivalent for longer than 3 months h) Active solid or non-solid malignancy or lymphoma within the prior two years Direct involvement in the design or the execution of the BCG-DENMARK-COVID trial Intervention and comparator: Participants will be randomised to BCG vaccine (BCG-Denmark, AJ Vaccines, Copenhagen, Denmark) or placebo (saline). […] All participants will receive one injection at inclusion, and no further treatment of study participants will take place. […] Blinding (masking): Participants will be blinded to treatment. […] The participant will be asked to leave the room while the allocated treatment is prepared. […] Once ready for injection, vaccine and placebo will look similar, and the participant will not be able to tell the difference.The physicians administering the treatment are not blinded.Numbers to be randomised (sample size): Sample size: N=1,500. | 2020-09-18 |
| 32943233 | At baseline and during treatment, circulating endothelial cell (CEC) counts and serum levels of interleukin-6 (IL-6), interleukin-8 (IL-8), C-reactive protein (CRP) and lactate dehydrogenase (LDH) were assessed. […] Narsoplimab treatment was associated with rapid and sustained reduction of CEC and concurrent reduction of serum IL-6, IL-8, CRP and LDH. […] Narsoplimab may be an effective treatment for COVID-19 by reducing COVID-19-related endothelial cell damage and the resultant inflammation and thrombotic risk. | 2020-09-18 |
| 32943372 | While providers are challenged with treatment decisions during the coronavirus disease 2019 (COVID-19) crisis, decision making ultimately falls in the hands of patients-at present, their perspective is poorly understood. […] To ascertain renal cell carcinoma (RCC) patients’ perspectives on COVID-19 and understand the associated implications for treatment. […] The survey comprised 45 items, including baseline demographic, clinicopathologic, and treatment-related information. […] Among patients with metastatic disease, 76% were receiving active therapy. […] While most patients preferred not to defer therapy (51%), patients receiving immune therapy regimens were less amenable to deferring therapy than those receiving targeted treatment (20% vs 47%). […] Despite high levels of anxiety surrounding COVID-19, many patients with RCC were inclined to adhere to existing schedules of surveillance (localized disease) and systemic treatment (metastatic disease). […] The coronavirus disease 2019 (COVID-19) pandemic has prompted many doctors to develop different treatment strategies for cancer and other chronic conditions. […] Given the importance of the patient voice in these strategies, we conducted a survey of patients with kidney cancer to determine their treatment preferences. […] Our survey highlighted that most patients prefer to continue their current strategies of kidney cancer treatment and monitoring. | 2020-09-18 |
| 32943404 | There are no determined treatment agents for the severe coronavirus disease 2019 (COVID-19); therefore, it is suggested that methylprednisolone, as an immunosuppressive treatment, can reduce the inflammation of the respiratory system. […] In the standard care group, six patients received corticosteroids by the attending physician during treatment and excluded from the ITT population. […] A total of two patients in each group (5·8% and 7·1% respectively) showed severe adverse events between initiation of treatment and the end of the study. | 2020-09-18 |
| 32943474 | Controversies of renin-angiotensin-aldosterone system inhibitors usage in patients with COVID-19 and meticulous handling of case with acute coronary syndrome categorically stresses cardiologists to bust the myths hovering around and set a standard guideline to counterfeit the fatality with timely diagnosis and treatment of COVID-19-induced ACI. […] In this review, we sought to summarise the current evidence of COVID-19-associated cardiac injury and suggest the implications for its proper diagnosis and treatment. | 2020-09-18 |
| 32943538 | Logistic regression showed increasing odds of respiratory failure with sC5b-9 (odds ratio 31.9, 95% CI 1.4 to 746, P = 0.03) and need for oxygen therapy with C4d (11.7, 1.1 to 130, P = 0.045). | 2020-09-18 |
| 32943628 | The ongoing Corona Virus Disease 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), has emphasized the urgent need for antiviral therapeutics. […] The viral RNA-dependent-RNA-polymerase (RdRp) is a promising target with polymerase inhibitors successfully used for the treatment of several viral diseases. […] The coronavirus RdRp complex represents an Achilles heel for SARS-CoV, supporting nucleoside analogues as promising candidates for the treatment of COVID-19. | 2020-09-18 |
| 32943758 | This retrospective study evaluated the clinical characteristics of severe CRS (sCRS, grade 3-4) induced by severe COVID-19 (40 patients) or chimeric antigen receptor T-cell (CAR-T) therapy as a comparator (41 patients). […] The diagnose and management of severe COVID-19-related sCRS can learn lessons from treatment of sCRS induced by CAR-T therapy. | 2020-09-18 |
| 32943831 | To describe the clinical experience with the delivery of intravitreal injection therapy to patients with various indications at a tertiary university hospital during the COVID-19 lockdown in Jordan. […] No new exposures or COVID-19 positive cases were traced to our location or time of therapy. […] The administration of intravitreal injection therapy during the COVID-19 lockdown under special safety precautions was feasible and successful. | 2020-09-18 |
| 32943897 | Anti-oxidative herbal medicines with evidence-based beneficial impacts in the treatment of diabetes mellitus can be suggested as an adjuvant therapy to its conventional treatments in patients infected with COVID-19. | 2020-09-18 |
| 32944012 | Low dose radiotherapy has been used in the pre-antibiotic era for the treatment of all kind of pneumonia, with relative success. […] The unimaginable daily death toll of thousands of victims dying from COVID-19 pneumonia and the marginal therapeutic value of agents tested, brings forward the re-evaluation of the position of radiotherapy in the treatment of late stage lethal COVID-induced respiratory failure. | 2020-09-18 |
| 32944087 | Multiple retrospective studies have strongly suggested that anticoagulant therapy improves the prognosis of people with COVID-19. […] However, validation of the safety and effectiveness of anticoagulant therapy for COVID-19 and greater awareness of this clinical therapeutic option are urgently needed. | 2020-09-18 |
| 32944088 | The rational treatment of a disease is based on the knowledge of its pathophysiology, the identification of a therapeutic target and the confirmation of the efficacy and safety of the selected therapeutic intervention in randomised controlled trials. […] Thus, at the present time, due to the lack of solid scientific data to support a therapeutic strategy, we truly are shooting in the dark with the treatment of COVID-19. | 2020-09-18 |
| 32944091 | This has emphasised the need for a better understanding of diversity aspects in healthcare to improve prevention, treatment and long-term consequences. | 2020-09-18 |
| 32944185 | EV treatment resulted in: (1) attenuation of inflammation (reduction of pro-inflammatory cytokines and neutrophil infiltration, M2 macrophage polarization); (2) regeneration of alveolar epithelium (decreased apoptosis and stimulation of surfactant production); (3) repair of microvascular permeability (increased endothelial cell junction proteins); (4) prevention of fibrosis (reduced fibrin production). | 2020-09-18 |
| 32944295 | Diagnostics, therapeutics and vaccines are urgently needed. […] We model the trimeric Spike protein, including flexible loops and all N-glycosylation sites, in order to elucidate accessible epitopes for antibody-based diagnostics, therapeutics and vaccine development. […] We identify 28 B-cell epitopes in the Spike structure and group them as non-affected by the glycan cloud versus those which are strongly masked by the glycan cloud, resulting in a list of favourable epitopes as targets for vaccine development, antibody-based therapy and diagnostics. | 2020-09-18 |
| 32944357 | We provide an overview of China’s response strategy that was based on the principles of early detection, isolation, management and treatment and involved not only the large-scale coordination of multiple governmental bodies but also grass-root community participation throughout the country. | 2020-09-18 |
| 32944387 | Cancer patients are regarded as a highly vulnerable population to SARS-CoV-2 infection and development of more severe COVID-19 symptoms, which is possibly due to the systemic immunosuppressive state caused directly by tumor growth and indirectly by effects of anticancer treatment. […] Currently, much effort has been directed toward studying the pathogenesis and treatment of COVID-19, but the risk profiles, prognoses, and treatment outcomes in cancer patients remain unclear. […] Based on the current literature, we summarize the risk profiles, clinical and biochemical characteristics, and therapy outcomes of COVID-19 infections in cancer patients. | 2020-09-18 |
| 32944456 | The most important factors associated with fear included getting infected (84.8%), quarantined (69.6%), not getting medical treatment (62%), losing a life (56.8%), and infecting family members (94.2%). | 2020-09-18 |
| 32944461 | A large number of inpatients with Coronavirus disease 2019 (COVID-19) in some regions of the United States may interfere with the ability of hospitals to take care of patients requiring treatment for other conditions. | 2020-09-18 |
| 32944506 | Along with the above measures in containment, healthcare service, medical treatment, and prophylaxis (presymptomatic testing) within mitigation are utilized to prevent a COVID-19 spread. | 2020-09-18 |
| 32944565 | Till our knowledge is improved, the most important intervention in the treatment of critically ill patients with COVID-19 seems to be the level of standard care and appropriate and early diagnosis and treatment. […] It seems that each center should have its protocol on the management of critically ill COVID-19 patients regarding prevention, diagnosis, and treatment. […] This treatment should now be performed regardless of the reason which lies behind the pathophysiology of this disease, which is yet unknown. | 2020-09-18 |
| 32944968 | SARS-CoV-2 is a highly infectious virus with no vaccine or antiviral therapy available to control the pandemic; therefore, it is crucial to understand the mechanisms of viral pathogenesis and the host immune responses to SARS-CoV-2. | 2020-09-18 |
| 32945026 | To investigate trends in surgical hair restoration treatment from both the surgeon and patient perspectives. […] Patient epidemiological and surgical data from the ISHRS were combined with search trend data from Google to analyze changing trends in surgical hair restoration treatment. […] It is in the best interest of all hair restoration providers to keep abreast of changing technologies and treatment trends to stay at the forefront of their profession. | 2020-09-18 |
| 32945085 | The clinical features and subsequent medical treatment, combined with the impact of a global pandemic, require specific nutritional therapy in hospitalised adults. | 2020-09-18 |
| 32945149 | Patients with malignancy are particularly vulnerable to infection with Severe Acute Respiratory Disease-Coronavirus-2 (SARS-CoV-2) given their immunodeficiency secondary to their underlying disease and cancer-directed therapy. […] We report a case series of patients with cancer who received convalescent plasma, an investigational therapy for severe Coronavirus Disease 2019 (COVID-19). […] Oxygen requirements and clinical outcomes of interests were captured as well as laboratory parameters at baseline and 3 days after treatment. […] Fifteen patients (62.5%) were on cancer-directed treatment at the time of COVID-19 infection. […] C-reactive protein significantly decreased after 3 days of treatment, while other laboratory parameters including ferritin and D-dimer remained unchanged. […] Convalescent plasma may be a promising therapy in cancer patients with COVID-19. | 2020-09-18 |
| 32945160 | The use of sewage water for irrigation is common in many developing countries, and it is only partially treated in the majority of countries with less than 10% of collected wastewater receiving any form of treatment globally. | 2020-09-18 |
| 32945241 | To that end, we describe our experience and approach in addressing COVID-19 outbreaks in meat processing facilities, which included three pillars of action based on public health ethics and international human rights: (1) worksite prevention and control, (2) community-based prevention and control, and (3) treatment. | 2020-09-18 |
| 32945590 | In this context, apitherapy presents as a promising source of pharmacological and nutraceutical agents for the treatment and/or prophylaxis of COVID-19. | 2020-09-18 |
| 32945597 | Twenty-four hour composite influent wastewater samples were collected from four wastewater treatment plants in Adelaide, South Australia for 7 consecutive days (Wednesday-Tuesday) every 2 months from April 2016-April 2020. | 2020-09-18 |
| 32945610 | Escalation of treatment and timely transition to inpatient care are critical when COVID-19 patients deteriorate. | 2020-09-18 |
| 32945634 | This interface is also a decisive factor in promoting patient empowerment, including specifying the time period envisaged for treatment in the new COVID-19 era in as calm a manner as possible. | 2020-09-18 |
| 32945644 | Pneumothorax, pneumomediastinum, bronchiectasis and cysts are probably underrated complications of COVID-19 that can worsen prognosis, in terms of prolonged hospitalization and need of oxygen therapy. | 2020-09-18 |
| 32945707 | We designed an easy-to-use clinically predictive tool for early identification and stratified treatment of older patients with severe COVID-19. | 2020-09-18 |
| 32945710 | Approximately 14% of UK hospital in-patients receive supplemental oxygen therapy, only 57% have valid prescriptions. […] Of the 636 patients admitted, 66 (10%) were receiving oxygen therapy. | 2020-09-18 |
| 32945803 | The COVID-19 pandemic caused many hospitals and treatment centers to temporarily restrict or prohibit visitors to control viral spread. | 2020-09-18 |
| 32945888 | To describe the utilization and imaging findings in children with COVID-19 along with the comorbidities, treatment and short-term outcomes. […] For children who were admitted to the hospital, we documented length of hospital stay, need for intensive care unit care/ventilator support, and treatment regimen. […] Of these, 92/313 (29%) were asymptomatic and 55/313 (18%) had imaging and were admitted to the hospital for treatment. | 2020-09-18 |
| 32945944 | Treatment with rituximab should be considered a possible risk factor for unfavorable outcomes in COVID-19 patients with RMD. | 2020-09-18 |
| 32946100 | Secondary outcomes of this study were patient complaints, diagnosis and treatments, treatment rejection rate, triage category data, the effects of age and gender, and the hospitalization rate. […] The treatment rejection rate was also higher in the pandemic period compared with the non-pandemic period (20% vs. | 2020-09-18 |
| 32946413 | AI was applied to COVID-19 in four areas: diagnosis, public health, clinical decision-making, and therapeutics. | 2020-09-18 |
| 32946479 | To examine the psychological impact of fertility treatment suspensions resulting from the COVID-19 pandemic and to clarify psychosocial predictors of better or worse mental health. 92 women from Canada and the United States (ages 20-45 years) whose fertility treatments had been cancelled were recruited via social media. […] Participants completed a battery of questionnaires assessing depressive symptoms, perceived mental health impact, and change in quality of life related to treatment suspensions. […] On a 7-point scale, participants endorsed a significant decline in overall quality of life (M(SD) = -1.3(1.3), p < .0001) as well as a significant decline in mental health related to treatment suspensions on a scale from -5 to +5 (M(SD) = -2.1(2.1), p < .001). […] Fertility treatment suspensions have had a considerable negative impact on women’s mental health and quality of life. | 2020-09-18 |
| 32946512 | The mean age of patients was 61.6 ± 10.8 years, 10 (76.9%) male, 8 (61.5%) were Black Americans, mean time from last normal was 4.97 ± 5.1 days, and only one received acute reperfusion therapy. | 2020-09-18 |
| 32946664 | Effective medical intervention by vaccination or therapy seems to be the only possibility to control the pandemic. | 2020-09-18 |
| 32946668 | The safety and efficacy of tocilizumab for the treatment of severe respiratory symptoms due to COVID-19 remain uncertain, in particular among solid organ transplant (SOT) recipients. […] Larger randomized studies are needed to identify whether there are subsets of SOT recipients who may benefit from tocilizumab for treatment of COVID-19. | 2020-09-18 |
| 32946801 | Multisystem inflammatory syndrome in children (MIS-C) associated with coronavirus disease (COVID-19) is a rare and challenging diagnosis requiring early treatment. […] This review aims to draw pediatrician attention to this diagnosis, suggesting early treatment strategies, and proposing a pediatric emergency care flowchart. […] Supportive treatment and early immunomodulation can control the intense inflammatory response and reduce complications and mortality. […] Further studies are needed to identify the disease pathogenesis and establish the most appropriate treatment. | 2020-09-18 |
| 32946870 | COVID-19 pandemic presents an unprecedented challenge to identify effective drugs for treatment. […] Despite multiple clinical trials using different agents, there is still a lack of specific treatment for COVID-19. […] Along with the aforementioned evidences and high safety profiles, both pentoxifylline and caffeine offer a glimpse of considerations for future use as a potential adjuvant to COVID-19 treatment. | 2020-09-18 |
| 32947043 | Quinoline (QN) derivatives are often used for the prophylaxis and treatment of malaria. | 2020-09-18 |
| 32947089 | Multi-organ involvement, delay in the diagnosis, incomplete work up and start of therapy, were registered in 50% of cases with a GBS-Disability scale ≥4 at follow-up evaluation. | 2020-09-18 |
| 32947121 | The probability of SARS-CoV-2 seropositivity was similar between men and women, type of treatment and cancer stage. | 2020-09-18 |
| 32947136 | The current treatment strategy includes repurposing of existing drugs that were found to be effective against other RNA viruses like SARS, MERS, and Ebola. […] This review presents a critical analysis of druggable targets of SARS CoV-2, new drug discovery, development, and treatment opportunities for COVID-19. | 2020-09-18 |
| 32947292 | In the treatment for severe acute respiratory distress syndrome (ARDS) from Coronavirus Disease 2019 (COVID-19), the World Health Organization (WHO) recommends prone positioning (PP) during mechanical ventilation for periods of 12-16 hours per day to potentially improve oxygenation and survival. | 2020-09-18 |
| 32947341 | Attention should be paid to the disease and population characteristics of patients with cleft lip with/without palate during diagnosis and treatment. | 2020-09-18 |
| 32947392 | Adolescents and young and middle-age adults with complex chronic or terminal illness often are not provided with timely, clear, complete information or palliative care support. […] Early palliative care for chronically ill patients facilitates discussions of prognostication and goals of care, in addition to providing symptom management. […] It is especially important that palliative care nurses promote and maintain these early and comprehensive discussions during the COVID-19 pandemic because this population is at a high risk of complications from the coronavirus. | 2020-09-18 |
| 32947478 | The risks and benefits of anticoagulation treatment should be considered in each case. | 2020-09-18 |
| 32947506 | Trials that have evaluated HCQ for COVID-19 treatment were recruited for statistical analysis with fixed- and random-effect models. […] HCQ-alone when used as a therapy in COVID-19 did not reveal significant changes in mortality rate, clinical progression, viral clearance and cardiac QT prolongation. […] Subsequent subgroup analysis showed that HCQ treatment could decrease mortality rate and progression to severe illness in severely-infected COVID-19 patients (OR 0.27, 95% CI 0.13-0.58). […] Our results indicated that HCQ-AZI combination treatment increased mortality rate in COVID-19, but it also showed benefits associated with viral clearance in patients. […] HCQ-alone used for treatment has revealed benefits in decreasing the mortality rate among severely-infected COVID-19 group and showed potential to be used for COVID-19 treatment in long-term follow-up period group. | 2020-09-18 |
| 32947555 | Fewer pretreatment steps correspond to lower chances of infection. | 2020-09-18 |
| 32947588 | In the second period, all patients admitted for fracture treatment were screened by RT-qPCR. | 2020-09-18 |
| 32947590 | Demographic data, COVID-19 symptoms, laboratory and radiographic examinations, and treatment methods were recorded. […] All patients (100%) were given antibiotic therapy, whereas 16 patients (80%) underwent hydroxychloroquine therapy and 8 (40%) were treated with corticosteroids. | 2020-09-18 |
| 32947759 | To explore the impact of the coronavirus disease lockdown on diabetes patients living in Jeddah, Saudi Arabia, in terms of their compliance with medication intake and lifestyle habits, and quality of life. […] The survey included questions on demographic data, type of diabetes, medications used, comorbidities, medication compliance, and daily habits before and after the lockdown, and those assessing patients’ psychological parameters during the past month by using the Kessler Psychological Distress Scale (K10). […] Antidiabetic monotherapy was used in 76.4% of the patients, while combination therapy was used in 23.6%. | 2020-09-19 |
| 32947798 | Among them, 30% were admitted to the intensive care unit, 45% developed acute respiratory distress syndrome, and 44% had acute kidney injury with 23% needing renal replacement therapy. | 2020-09-19 |
| 32947927 | Several promising therapeutics are under investigation to the overall prognosis of COVID-19 patients with high risk of cardiovascular impairment, nevertheless to date, none have shown proven clinical efficacy. | 2020-09-19 |
| 32947974 | Currently the ultimate treatment is palliative; however, many modalities have been introduced with effective or minimal outcomes. […] This critical review was conducted to understand COVID-19 disease and highlights the prevailing facts that link phototherapy utilisation as a potential treatment modality for SARS-CoV-2 viral infection. […] Therefore, phototherapy is a promising treatment modality, which needs to be validated further for COVID-19 by robust and rigorous randomised, double blind, placebo-controlled, clinical trials to evaluate its impartial outcomes and safety. | 2020-09-19 |
| 32947988 | Methods: Four COVID-19 outcomes were used: severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) seroprevalence, hospitalizations for COVID-19 symptoms, admissions to intensive care units for reasons related to SARS-CoV-2, and deaths attributable to COVID-19. […] At multivariable analyses, influenza vaccination coverage rates correlated independently with SARS-CoV-2 seroprevalence (Beta (95% C.I.): -130 (-198, -62); p = 0.001), hospitalizations for COVID-19 symptoms (Beta (95% C.I.): -4.16 (-6.27, -2.05); p = 0.001), admission to intensive care units for reasons related to SARS-CoV-2 (Beta (95% C.I.): -0.58 (-1.05, -0.12); p = 0.017), and number of deaths attributable to COVID-19 (Beta (95% C.I.): -3.29 (-5.66, -0.93); p = 0.010). | 2020-09-19 |
| 32948116 | There is no specific drug for the treatment of COVID-19 patients at this moment. | 2020-09-19 |
| 32948238 | Coronavirus disease 2019 (COVID-19) has shown high infection and mortality rates all over the world, and despite the global efforts, there is so far no specific therapy available for COVID-19. […] Inclusion of both males and females in basic research and clinical trials is required to provide critical information on sex-related differences that may help to better understand disease outcome and therapy. | 2020-09-19 |
| 32948243 | We conducted a multicentre retrospective observational study evaluating all the COVID-19 patients received in four intensive care units (ICUs) of four tertiary hospitals in the UK between March 15, 2020, and May 05, 2020. | 2020-09-19 |
| 32948322 | These include identifying potential cases of child maltreatment without the support normally provided by teachers and child carers; and establishing and maintaining contact with clients under physical distancing rules. | 2020-09-19 |
| 32948334 | Extracorporeal membrane oxygenation (ECMO) provides effective respiratory support and saves time for the treatment of severe COVID-19. | 2020-09-19 |
| 32948378 | Thus far, there is no medication or vaccine to prevent and control the spread of COVID-19. | 2020-09-19 |
| 32948420 | This emerging health crisis calls for the urgent development of specific therapeutics against COVID-19 to potentially reduce the burden of this emerging pandemic. […] This study will hopefully pave a way for development of phytonutrients-based antiviral therapeutic for treatment or prevention of COVID-19 and further studies are recommended to evaluate the antiviral effects of these phytochemicals against SARS-CoV-2 in in vitro and in vivo models. | 2020-09-19 |
| 32948465 | Such a bioproduct is often used routinely for substitution therapy of thrombotic thrombocytopaenic purpura. | 2020-09-19 |
| 32948577 | These findings demonstrate a robust research response to the COVID-19 pandemic, though many of the currently planned and ongoing trials focus on a small number of potential therapies, and many also lack essential design features and power necessary to provide accurate treatment effect estimates. | 2020-09-19 |
| 32948617 | In SSA countries with limited healthcare workforce, hospital resources and intensive care units, a robust system of social distancing, contact tracing and face mask use could yield in outcomes that prevent several millions of infections and thousands of deaths across the continent. | 2020-09-19 |
| 32948888 | Of all COVID-19 patients 3% need intensive care treatment, which becomes a great challenge for anesthesiology and intensive care medicine, medically, hygienically and for technical safety requirements. […] For these team members, a consistent use of personal protective equipment (PPE) is essential.Due to the immense medical challenges, the following treatment guidelines were developed by the ÖGARI (Österreichische Gesellschaft für Anästhesiologie, Reanimation und Intensivmedizin), FASIM (Federation of Austrian Societies of Intensive Care Medicine) and ÖGIAIN (Österreichische Gesellschaft für Internistische und Allgemeine Intensivmedizin und Notfallmedizin). | 2020-09-19 |
| 32948978 | Although liver transplantation has been performed for patients with ATTRv amyloidosis since 1990, late-onset patients were not eligible for this treatment. […] A strategy for monitoring patients that enables the choice of an appropriate treatment from comprehensive and long-term viewpoints should be established. | 2020-09-19 |
| 32948990 | On top of meeting urgent needs of patients for medical treatment, the emergency department also has to devote resources into investigation and prevention of COVID-19. | 2020-09-19 |
| 32949098 | Our multi-institutional experience suggests the prognoses of pediatric transplant recipients infected with COVID-19 may mirror those of immunocompetent children, with infrequent hospitalization and minimal treatment, if any, required. | 2020-09-19 |
| 32949269 | Some patients, despite receiving lung-protective ventilation and maximal medical therapy, develop refractory hypoxemia, rendering candidates for extracorporeal membrane oxygenation (ECMO) support. | 2020-09-19 |
| 32949380 | Patients with previous treatment with ACEi or ARB presented similar incidence of the combined endpoint during hospitalisation (31.6% vs. […] 41.2%; p = 0.03) compared with those without prior treatment. | 2020-09-19 |
| 32949449 | No treatment was needed. | 2020-09-19 |
| 32949577 | IL-1RA and GM-CSF were significantly lower in severe patients and those who needed treatment targeting the immune system (p < 0.05). | 2020-09-19 |
| 32949761 | Palliative care is an essential component of the COVID-19 pandemic response, but is overlooked in national and international preparedness plans. […] The preparedness and capacity of African palliative care services to respond to COVID-19 is unknown. […] To evaluate the preparedness and capacity of African palliative care services to respond to the COVID-19 pandemic. […] It was emailed to the 166 African Palliative Care Association’s members and partners. […] Most services (80%) reported having the capacity to use technology instead of face-to-face appointment, and half (52%) reported having palliative care protocols for symptom management and psychological support that could be shared with non-specialist staff in other healthcare settings. […] Our survey suggests that African palliative care services could support the wider health system’s response to the COVID-19 pandemic with greater resources such as basic infection control materials. | 2020-09-19 |
| 32949888 | The traditional Chinese Medicine (TCM) herbal formula Lian Hua Qing Wen (LHQW) improves the results of COVID-19 treatment. […] Extensive detailed Network Pharmacology analysis of the LHQW- treatment mechanism in COVID-19. […] Detailed network analysis shows, that LHQW herbal TCM treatment modulates the inflammatory process, exerts antiviral effects and repairs lung injury. | 2020-09-19 |
| 32950003 | The study supports the safety of this therapy in patients with COVID-19. | 2020-09-19 |
| 32950037 | Dental treatment should be limited to patients with urgent or emergency situation. | 2020-09-19 |
| 32950044 | Aim In this study, we aim to investigate the efficacy of convalescent plasma (CP) according to blood groups (BGs) in the treatment of critically ill patients diagnosed with COVID-19. | 2020-09-20 |
| 32950067 | Thus, multiple clinical trials assessing the potential of MSCs for COVID-19 treatment are underway. […] We show that MSCs are resistant to SARS-CoV-2 infection and retain their immunomodulation potential, supporting their potential applicability for COVID-19 treatment. | 2020-09-20 |
| 32950177 | Appropriate dose and duration of therapy are unknown. | 2020-09-20 |
| 32950268 | Dynamic monitoring of these parameters would benefit therapy planning and prognosis evaluation. | 2020-09-20 |
| 32950309 | In recent weeks, papers have been published describing coagulation disorders and arterial and venous thrombotic complications in these patients, mainly among those admitted to intensive care units. […] Until sufficiently robust information (preferably from well-designed clinical trials) is available, the recommendations of clinical practice guidelines for the prophylaxis, diagnosis and treatment of VTE should be followed in Covid-19 patients. | 2020-09-20 |
| 32950434 | We describe the epidemiological and clinical data, laboratory and imaging findings, as well as treatment and outcome in these patients. | 2020-09-20 |
| 32950636 | Nasoil® counts as one of its main components, Asclepias curassavica extracts, and in the present study it has been shown that it is an effective adjuvant in the treatment of Covid-19, increasing the respiratory capacity of the patients (SpO2> 90%) and reducing the symptoms from the first application, improving the patients around the fifth to the eighth application. | 2020-09-20 |
| 32950685 | Qualitatively, the following 3 themes were identified: unexpected challenges of food shopping; less food-related food anxiety during the pandemic; and differences and delays in food allergy testing and therapy. | 2020-09-20 |
| 32950697 | It is necessary to continue with the genomic surveillance of S and N proteins during the SARS-CoV-2 pandemic as this information can be useful for developing vaccines, therapeutics and diagnostic tests. | 2020-09-20 |
| 32950880 | The new night shift schedule might improve the continuity of treatment, thereby improving the overall quality of medical work and reducing the mortality of critically ill patients. | 2020-09-20 |
| 32950986 | COVID-19 pandemic, a global threat, adversely affects all daily lives, altered governmental plans around the world, and urges the development of therapeutics and prophylactics to avoid the expansion of the viral infection. […] The amalgamation of IF and a ketogenic diet rich in MCTs is thought to work as a prophylactic measure for normal people and adjunct therapy for infected persons. […] Key Message: A diet regimen of ketogenic breakfast along with supplementation with two doses of lauric acid-rich MCTs at breakfast and lunch times, followed by 8-12-h IF and a dinner rich with fruits and vegetables, could be a potential prophylactic strategy and adjuvant therapy to combat SARS-CoV-2 infections. | 2020-09-20 |
| 32951037 | Symptoms resolved during treatment. | 2020-09-20 |
| 32951058 | Tracheotomy in critically ill patients with COVID-19 who meet the indications for tracheotomy potentially represents a safer approach to manage the airway and help improve the treatment outcomes. | 2020-09-20 |
| 32951151 | Currently, no cure or standard treatment for COVID-19 exists. | 2020-09-20 |
| 32951291 | This has caused concomitant setbacks in the treatment and control of major health issues like HIV, tuberculosis, measles, and malaria in the country. | 2020-09-20 |
| 32951300 | She improved after reduction of immunosuppressive treatment and had two consecutive negative reverse transcription polymerase chain reaction (RT-PCR) tests. | 2020-09-20 |
| 32951564 | We report the case of a 38 year-old man living with well-controlled HIV on antiretroviral therapy who developed cerebellar symptoms and was admitted to hospital for management of an intraventricular cryptococcoma. | 2020-09-21 |
| 32951723 | Presentation of a case illustrating the benefits of traditional Chinese medicine (TCM) for treatment of Coronavirus disease 2019 (COVID-19) in critically ill patients. […] Then she received the combined therapy of a modified Chinese herbal formula and Western medicine. […] During a twelve-day period of treatment, her respiratory distress and appetite quickly improved. | 2020-09-21 |
| 32951919 | Despite their limitations, they have been well tolerated by patients and improved patient safety and treatment. | 2020-09-21 |
| 32951933 | The authors present a novel SAFET-I Tool that outlines the following five components of effective sexual assault patient care: stabilization, alert system activation, forensic evidence consideration, expedited post-assault treatment, and trauma-informed care. […] A SAFET-I Tool is presented to assist emergency health care providers in the treatment and advocacy of sexual assault patients during a period with increasing rates of IPV. | 2020-09-21 |
| 32951959 | Baseline characteristics, stroke subtype, workup, treatment and outcome are presented as total number and percentage or median and interquartile range. | 2020-09-21 |
| 32952079 | All baseline characteristics, therapy received, outcomes and MERS-CoV status were obtained from the chart review. […] PCI was performed in 74, coronary artery bypass grafting (CABG) in 28 and conservative therapy was prescribed for 46 patients. | 2020-09-21 |
| 32952147 | He was provided supportive treatment along with steroid and antibiotics. | 2020-09-21 |
| 32952306 | Data collection included the indication of admission to ITU, duration of intubation, types of medical devices utilised to secure the endotracheal tube, requirement of vasopressor agents and renal replacement therapy, presence of other associated ulcers, duration of proning and mortality. | 2020-09-21 |
| 32952312 | The SARS-CoV‑2 pandemic represents a great challenge worldwide not only under the aspect of treatment but also of prevention. | 2020-09-21 |
| 32952483 | Availability of a low-dose therapy for lung inflammation could have dramatically decreased the impact of the COVID-19 pandemic. | 2020-09-21 |
| 32952595 | Ramatroban, used for the treatment of allergic rhinitis in Japan for the past 20 years has an excellent safety profile. […] Therefore, Ramatroban merits investigation as a novel immunotherapy for the treatment of COVID-19 disease. | 2020-09-21 |
| 32952596 | Until now, there is no clinically approved vaccine or drug for the treatment of COVID-19, and the conquest to find a novel therapy for this global havoc is being undertaken at a warlike pace. […] Further, it may be used as a prevention or treatment strategy in combination with other drugs. | 2020-09-21 |
| 32952617 | Its high infectivity and moderate mortality have resulted in an urgent need to find an effective treatment modality. […] The inherent antiviral activity could be a treatment choice for patients with coexisting rheumatological disorders and infections. […] This review covers DMARDs of treatment potential for SARS-CoV-2 in part I, and antiviral mechanisms plus trial evidence for viruses other than SARS-CoV-2 in part II. | 2020-09-21 |
| 32952811 | He was diagnosed with CMV myocarditis with cardiac insufficiency and totally recovered without antiviral therapy. | 2020-09-21 |
| 32952820 | The patients presented to the ENT Department where they received no therapy and underwent outpatient surveillance. […] Recovery of the smell is possible after a few weeks without medical treatment. | 2020-09-21 |
| 32952854 | At present, there is no specific drug or efficient treatment for this disease. […] In this analysis based on evidential relationships of the biological characteristics of MSCs, especially umbilical cord (UC)-derived MSCs as well as the first clinical trial using MSCs for COVID-19 treatment, we discuss the use of UC-MSCs to improve the symptoms of COVID-19 in patients. | 2020-09-21 |
| 32952855 | Currently, no specific treatment or vaccination against severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has been developed. […] Mesenchymal stromal cells (MSCs), which are known for their immunosuppressive actions, could be applied as an alternative co-therapy in critically-ill COVID-19 patients. […] Moreover, MSC treatment may be effective for the reversion of ground-glass opacity of damaged lungs and reduce the tissue fibrosis. […] Taking into account the multifunctional properties of MSCs, the proposed stem-cell-based therapy may be proven significantly effective in critically-ill COVID-19 patients. | 2020-09-21 |
| 32952870 | Other factors must also be considered in these analyses, such as the repercussions of hemodynamic changes, the presence of thrombotic events, and, mainly, the possible drug-induced liver injury with the current, yet off-label, treatment. | 2020-09-21 |
| 32952875 | In recent years, significant progress in the antiviral treatment of chronic hepatitis C (CHC) has been made due to the development of interferon-free therapies. […] According to the current recommendations, all treatment-naïve and treatment-experienced children with CHC virus infection should be considered for DAA therapy to prevent the possible progression of hepatitis C virus-related liver disease and its complications. […] These efforts include promoting telemedicine in the outpatient setting, using local laboratory testing for follow-up visits, and engaging in the home delivery of DAAs for patients under antiviral therapy whenever possible. | 2020-09-21 |
| 32952967 | The purpose of the present review is to give an update regarding the classification, epidemiology, clinical manifestation, diagnoses, and treatment of the Rickettsial diseases present in the Mediterranean area. […] The correct understanding of the clinical features, diagnostic tools, and proper treatment can assist clinicians in the management of Rickettsioses in the Mediterranean area. | 2020-09-21 |
| 32952981 | Cancer patients are immunosuppressed from their disease and the therapy they receive. | 2020-09-21 |
| 32953091 | Methods: Nineteen mechanically ventilated adult ewes undergoing intensive care during evaluation of a form of ECLS (treatment) for acute lung injury were used to collate clinical observations. […] Eight sheep were injured by acute smoke inhalation prior to treatment (injured/treated), while another eight were not injured but treated (uninjured/treated). […] Results: Compared with the baseline, treatment contributed to and exacerbated the deterioration of pulmonary pathology by reducing lung compliance and the arterial oxygen partial pressure to fractional inspired oxygen (PaO 2/FiO 2) ratio. | 2020-09-21 |
| 32953249 | Such major outbreaks demand classification and origin of the virus genomic sequence, for planning, containment, and treatment. | 2020-09-21 |
| 32953275 | The assays have immediate utility in supporting clinical diagnostics, understanding transmission in high-risk cohorts and underpinning longer‑term ‘exit’ strategies based on effective vaccines and therapeutics. | 2020-09-21 |
| 32953290 | SARS-CoV-2 infection is known to cause a hypercoagulable state resulting in acute thrombotic events, including venous thromboembolism, acute myocardial infarction, acute stroke, acute limb ischemia, and clotting of ECMO (extracorporeal membrane oxygenation) and CRRT (continuous renal replacement therapy) catheters. […] This case emphasizes that COVID-19 induced hypercoagulable state can cause massive thrombosis, and patients might need anticoagulation therapy. […] However, clinicians should also consider the risk of hemorrhagic complications of the disease and be cautious when administering anticoagulant therapy in selected cases. | 2020-09-21 |
| 32953385 | COVID-19 is a new infectious disease causing severe respiratory failure and death for which optimal treatment is currently unclear. […] Many therapies have been proven to be ineffective; however, promising findings related to corticosteroid therapy have been published. […] Analysis of published data including in this issue suggests that therapy with corticosteroids in the range of 6 mg of dexamethasone (or equivalent) per day likely has a positive effect in patients requiring mechanical ventilation but there remains considerable doubt in patients over the age of 70, in patients with diabetes and patients with milder disease. | 2020-09-21 |
| 32953445 | As there is no definite antiviral therapy for the treatment of cases with COVID-19 the best option for slowing down the pandemic and reducing mortality rates is protection against the virus of interest. | 2020-09-21 |
| 32953526 | The continual and almost daily improvement in the information associated with this viral infection has been spectacular, notably in the areas of epidemiology, pathophysiology and therapy. | 2020-09-21 |
| 32953732 | This study aims to assess the clinical features of fracture patients at our hospital during the COVID-19 outbreak and formulate the medical steps to ensure the effective treatment of fracture patients with minimal risk of infection to healthcare workers. […] Following the orthopedic treatment regimen followed at our hospital, all patients had non-life-threatening limb fractures. | 2020-09-21 |
| 32953741 | Standard treatment protocols and patient-centered care in the mobile cabin hospitals in this study provided the chance for COVID-19 patients to successfully improve their mental health during the outbreak of the pandemic. | 2020-09-21 |
| 32953842 | We present a literature review on the extent to which research in this field has developed over the years, and reveal gaps in gender-sensitive awareness between the clinical portrayal and the translation into gender-specific treatment regimens, guidelines and into gender-oriented preventive strategies and health policies. | 2020-09-21 |
| 32953843 | Importantly, this presumption provides the rationale for utilization of therapy, until recently reserved mostly for autoimmune diseases (ADs), in the management of COVID-19 hyperinflammation condition and has led to an extensive discussion for the potential benefits and detriments of immunosuppression. […] The administration of pharmaceutical therapy should not undermine the physical and psychological status of the patient with the maximum utilization of telemedicine. […] Researchers and clinicians should be vigilant for upcoming research for insight and perspective to fine-tune the clinical guidelines and practice and to weigh the potential benefits and detrimental effects of the applied immunomodulating therapy. | 2020-09-21 |
| 32953852 | The Diagnosis and Treatment Guidelines of New Coronavirus Pneumonia (7th Edition) includes tocilizumab as a recommended drug for immunotherapy in severe and critical COVID-19 patients. […] However, the specific clinical efficacy of tocilizumab in the treatment of COVID-19 patients is worth studying. […] The imaging manifestations and clinical data before and after treatment were analyzed retrospectively, including routine peripheral venous blood tests, routine blood biochemical tests, coagulation test, C-reactive protein (CRP), IL-6, and arterial blood gas analysis. […] Of the 19 patients in this group, 13 (68.4%) had significantly improved symptoms of COVID-19 (5 patients were discharged directly and 8 patients were transferred after improvement) following treatment. […] Tocilizumab treatment is effective against IL-6 in COVID-19 patients, but it does not completely inhibit the inflammation and cytokine storm in all patients with COVID-19. […] In the clinical treatment of COVID-19 patients, attention should be paid to the timing of drug administration and other adjuvant treatments. | 2020-09-21 |
| 32953870 | This case report of the diagnosis and treatment of an elderly patient with 2019-nCoV pneumonia complicated by acute exacerbation of chronic obstructive pulmonary disease in Gansu Province aims to provide a better reference for the treatment of patients in the future. […] She was subsequently admitted to Gansu Provincial Hospital of Traditional Chinese Medicine for isolation and transferred to Tianshui Gansu Provincial Hospital of Infectious Diseases on February 3, 2020 for treatment. […] After active treatment, she was discharged on February 14 with a good prognosis. […] Attention should be paid to the prevention and treatment of multiple organ dysfunction syndrome. […] It is feasible to carry out dynamic and continuous index monitoring, which can predict and guide the prevention and treatment of multiple organ dysfunction and the prognosis of the disease. | 2020-09-21 |
| 32953968 | Multivariate cox proportional hazards analysis showed that primary endpoint (mortality) was determined by overweight/obesity (OR 1.290, 95% CI 0.115-0.730; p = 0.009), ferritin levels (OR 1.001, 95% CI 1.000-1.001; p < 0.001), myocardial injury (OR 3.764, 95% CI 1.307-10.838; p = 0.014), septic shock (OR 4.104, 95% CI 1.142-14.132; p = 0.024), acute respiratory distress syndrome (OR 3.001, 95% CI 1.008-10.165; p = 0.040), and treatment with Hydroxychloroquine/Azithromycin (OR 0.357, 95% IC 0.133-0.955; p = 0.040). | 2020-09-21 |
| 32953990 | COVID 19 patients over 18 years of age, admitted to hospital and under treatment with LPV/r were included. […] A screening of potential interactions related to LPV/r and home and hospital medication was carried out. […] The prevalence of potential interactions in COVD 19 patient undergoing treatment with LPV/r is high, with age (>65), ICU admission, previous respiratory and psychiatric pathology, dyslipidemia and the number of prescribed drugs acting as risk factors. | 2020-09-21 |
| 32954209 | One of the most crucial causes of lack of mental screening, recognition, and treatment is the limited availability of mental health trained providers. | 2020-09-21 |
| 32954211 | Moreover, during a pandemic, given the great number of patients needing treatment, TEE probes and monitoring devices are not widely available. | 2020-09-21 |
| 32954212 | We believe that, in the treatment of COVID-19 and its complications during pregnancy, cytokine filter treatment can give time to patient for hemodynamic and metabolic stabilization. | 2020-09-21 |
| 32954217 | In particular, emphasis is placed on how HIV testing programs, which are supported by systematic peer outreach, are being disrupted at a time when global policymakers call for expanded HIV testing and treatment targets among key populations. | 2020-09-21 |
| 32954232 | In the course of participating in the treatment of COVID-19, there was no statistically significant difference in positive rates between high-risk departments and low-risk departments (P>0.05). | 2020-09-21 |
| 32954247 | The SARS-CoV-2 pandemic has resulted in the development of various therapeutics to treat and prevent major complications related to the virus; pregnant patients are vulnerable to acquiring SARS-CoV-2 due to frequent contact with the healthcare setting. […] Despite publication of a plethora of case series and randomized control trials of SARS- CoV-2 therapeutics, few have addressed treatment in the pregnant population. […] To date, there have been no published review of therapeutics in the pregnant patient infected with SARS-CoV-2. […] We provide the first review of available treatments for SARS-CoV-2, various trials with inclusion and exclusion of the pregnant patients, and potential side effects of each treatment in the pregnant patient. | 2020-09-21 |
| 32954488 | Following patients with psoriasis on biological therapy, as well as other inflammatory and autoimmune cutaneous disorders such as atopic dermatitis, pemphigus, pemphigoid diseases, and skin cancer provoked the interest of dermatologists. | 2020-09-21 |
| 32954492 | In this retrospective study, epidemiological, clinical, laboratory, treatment and outcomes data of hospitalized patients with severe COVID-19 in Zhongnan Hospital of Wuhan University from January 1 to 7 March 2020, were collected. | 2020-09-21 |
| 32954592 | This study tested changes in reported incidents, in particular regarding aggression, unexplained absence and, for contrast, medication errors. […] The imposition of lockdown-measures coincided with a significant drop in incidents (total, P < .001; aggression, P = .008; unexplained absences, P = .008; and medication errors, P < .001). […] Incidents in total (P = .001) and with aggression (P < .001) then climbed from this initial low level, while medication errors remained stably low (P = .94). | 2020-09-21 |
| 32954595 | Patients with anorexia nervosa (AN) and with obesity endorsed a positive response to treatment during confinement, no significant changes were found in bulimia nervosa (BN) patients, whereas Other Specified Feeding or Eating Disorder (OSFED) patients endorsed an increase in eating symptomatology and in psychopathology. […] Furthermore, AN patients expressed the greatest dissatisfaction and accommodation difficulty with remote therapy when compared with the previously provided face-to-face therapy. | 2020-09-21 |
| 32954601 | The patients’ coagulation parameters and acute-phase reactants were evaluated both before and after treatment. […] Early hospitalization and medical treatment can alleviate symptoms, improve the clinical course and reduce the need for ICU in symptomatic pregnant patients with suspected or confirmed COVID-19. | 2020-09-21 |
| 32954605 | Nurse competence is essential for ensuring quality treatment and care for these patients; however, research on nursing strategies for patients with respiratory insufficiency is limited. […] This study explored nurses’ perspectives on and nursing strategies in patients with respiratory insufficiency when admitted to three different intensive care units. […] Nursing strategies included balancing nursing interventions, conducting medical treatment, and taking a whole-person approach to patients’ needs. […] Caring for patients with respiratory insufficiency requires nurses with experience; competence in observation, assessment, and medical treatment; and a whole-person approach to patients’ needs. | 2020-09-21 |
| 32954754 | A total of 42 patients, who were diagnosed with COVID-19 and treated with XBJ combined with routine treatment at Chongqing University Three Gorges Hospital between January 20, 2020, and March 11, 2020, were selected as the observation group. […] A control group comprising 16 patients who received routine treatment was also established, and cases were matched from the observation group on a 1:1 basis according to age, comorbidities, and mild and severe disease. […] The clinical symptoms, laboratory test indexes, and changes in computed tomography (CT) scans of patients in the two groups were observed at the time of admission and 7 days after treatment, and the time taken for the patients to produce a negative nucleic acid test was also recorded. […] After treatment, there were significant improvements in IL-6 levels and body temperature in the observation group as compared with the control group. […] The results of this study suggest that routine treatment combined with XBJ can better improve the clinical outcomes of COVID-19 patients. | 2020-09-21 |
| 32954998 | Additionally, the plant lectins can be used as potential therapeutics against bacteria, fungus, yeast and protozoa. | 2020-09-21 |
| 32955080 | Treatment and management of severe acute respiratory syndrome coronavirus-2, which causes coronavirus disease (COVID-19), requires increased adoption of personal protective equipment (PPE) to be worn by workers in healthcare and industry. | 2020-09-21 |
| 32955081 | Treatment with leflunomide was not associated with a difference from the interferon alone group in the duration of viral shedding (hazard ratio for negative RT-PCR, 0.70; 95% confidence interval, 0.391-1.256; P=0.186). […] In COVID-19 patients with prolonged PCR positivity, no benefit in terms of the duration of viral shedding was observed with the combined treatment of leflunomide and IFN α-2a beyond IFN α-2a alone. | 2020-09-21 |
| 32955087 | Information presented for each therapy included the rationale for use, summaries of clinical trials or experience, trial registry numbers, and dosage regimens. | 2020-09-21 |
| 32955456 | A necessary shift from in-person to remote delivery of psychotherapy (eg, teletherapy, eHealth, videoconferencing) has occurred because of the COVID-19 pandemic. […] Evidence for the effectiveness of digital delivery of prolonged exposure therapy, cognitive processing therapy, behavioral activation treatment with therapeutic exposure to military members, veterans, and PSP was rated level 1a, whereas evidence for cognitive behavioral therapy was conflicting. […] The narrative synthesis indicated that virtual delivery of these therapies can be as effective as in-person delivery but may reduce stigma and cost while increasing access to therapy. | 2020-09-21 |
| 32955471 | The problem needs both a diagnosis and robust treatment in order to have better outcomes at the individual, organisational and national levels. | 2020-09-21 |
| 32955610 | This specifically affects patients with rheumatological diseases, who often require immunosuppressive therapy and are thus at risk for infections. | 2020-09-21 |
| 32955770 | Identifying a functional association between SARS-CoV-2 infection and the process of biological aging may provide a tractable avenue for therapy to prevent acute and long-term disease. | 2020-09-21 |
| 32955785 | No specific antiviral agents have been adequately evidenced for the treatment of coronavirus disease 2019 (COVID-19). […] Although metformin has been recommended as a host-directed therapy for COVID-19, there are some opposite views. […] We enrolled 110 hospitalized patients with COVID-19 with diabetes prescribed either metformin or non-metformin hypoglycemic treatment for a case-control study. […] Antidiabetic therapy with metformin was associated with a higher risk of disease progression in patients with COVID-19 with diabetes during hospitalization (adjusted odds ratio = 3.964, 95% confidence interval 1.034-15.194, P = 0.045). | 2020-09-21 |
| 32955801 | There was no evidence concerning the prophylaxis with hydroxychloroquine, and only low-grade evidence regarding the use of hydroxychloroquine as a treatment for COVID-19 patients. […] 175 (22.3%) of respondents declared they (would) give the treatment to their close ones, and this decision was associated with a higher age (P = 0.003), and the opinion that there was evidence (P < 0.001). […] When asked about the source of the treatment regimen, 286 (36.4%) indicated a scientific paper, while no scientific paper about the prophylaxis with hydroxychloroquine existed at that time. | 2020-09-21 |
| 32955819 | Primary per-cutaneous coronary intervention (PPCI) as treatment of choice for ST-Elevation Myocardial Infarction (STEMI) should be performed rapidly. | 2020-09-21 |
| 32955901 | Arbidol was used in the treatment of COVID19, which was the most critical health problem in the world. […] Many countries still use this drug in the treatment of COVID19. […] We aimed to determine whether Arbidol, the hemagglutinin esterase inhibitor used in the treatment of COVID-19, was effective against SARS Cov-2 in silico. | 2020-09-21 |
| 32955902 | Keywords: coronavirus, COVID-19, dental strategies, dental treatment recommendations. | 2020-09-21 |
| 32956164 | Investment in research of digital clinical trials for SUDs provides an opportunity to cultivate benefits for research and clinical care long-term as we can (1) define regulatory requirements for the implementation of digital systems, (2) develop consensus on system-wide standards and protocols in the appropriate use of technology, and (3) gain experience that can translate to the treatment of patients with SUDs through telehealth in the community. | 2020-09-21 |
| 32956343 | The quality of the evidence that supported the recommendations on treatment schedules was assessed. […] Treatment schemes are recommended for each condition, prioritizing hypo-fractionated schemes whenever possible. | 2020-09-21 |
| 32956615 | The importance of a multidisciplinary team in decision making for children with PIMS-TS is highlighted throughout the guidance, along with the recommended treatment options, including supportive care, intravenous immunoglobulin, methylprednisolone, and biological therapies. […] This process has directly informed new PIMS-TS specific treatment groups as part of the adaptive UK RECOVERY trial protocol, which is the first formal randomised controlled trial of therapies for PIMS-TS globally. | 2020-09-21 |
| 32956644 | Since SARS-CoV-2 is genetically 80% homologous with the SARS-CoVs family, it is hypothesized that medications developed for the treatment of SARS-CoVs may be useful in the control and management of SARS-CoV-2. […] In this regard, some medication being tested in clinical trials and in vitro studies include anti-viral RNA polymerase inhibitors, HIV-protease inhibitors, anti-inflammatory agents, angiotensin converting enzyme type 2 (ACE 2) blockers, and some other novel medications. | 2020-09-21 |
| 32956664 | Because of the best energy of interaction, these three molecules could have the most potential antiviral treatment of COVID-19 than the other studied compounds. | 2020-09-21 |
| 32956782 | Hydroxychloroquine (HCQ) and azithromycin (AZT) have been proposed for COVID-19 treatment. […] A total of 112 consecutive COVID-19 patients were included in this analysis and were divided in 3 groups according to the receiving therapeutic regimens: 19 (17%) patients in Group 1 (no treatment), 40 (36%) in Group 2 (HCQ only), 53 (47%) in Group 3 (HCQ/AZT). […] The HCQ/AZT combination therapy causes a significantly increase of QT interval compared to HCQ alone. […] The use of such drugs may be considered as safe relating to arrhythmic risk in the treatment of COVID-19 patients as no arrhythmic fatalities occurred. | 2020-09-21 |
| 32956895 | Acetylsalicylic acid combined with intravenous immunoglobulin (IVIG) is the standard treatment of Kawasaki disease (KD). […] New intervention is important to overcome the problem of IVIG treatment resistance. | 2020-09-21 |
| 32957032 | Further research on the relationship of the EEG findings to the clinical state and short- or long-term prognosis of COVID-19 patients may be conducted to help clinicians discern which patients would necessitate an EEG procedure and would eventually require treatment. | 2020-09-21 |
| 32957057 | We aimed to evaluate patient perspectives regarding the use of Natalizumab and anti-CD20 therapies (Rituximab and Ocrelizumab) in the context of the COVID-19 pandemic. cross-sectional study conducted via voluntary survey filled in by patients with MS and related disorders receiving their infusional treatment in one MS centre in Australia, exploring their concerns regarding their therapy, their therapy and COVID-19, precautions undertaken in response to the pandemic, and factors impacting their decision-making. 170 patients completed the survey. | 2020-09-21 |
| 32957112 | Enormous efforts are underway for rapid vaccine and treatment developments. […] In this review, we point out the roles and possible contribution of EVs in viral infections, as well as ongoing EV-based approaches for the treatment of COVID-19, including clinical trials. […] EV-based therapies, especially the mesenchymal stem cell-derived EVs, are being intensively studied for the treatment of COVID-19. | 2020-09-21 |
| 32957305 | The study aims to evaluate the efficacy and safety of probiotic therapy for coronavirus disease 2019 with diarrhea. | 2020-09-22 |
| 32957323 | The purpose of this protocol is to systematically evaluate the effects of Qigong on lung function and quality of life in COVID-19 patients, and to add evidence to evidence-based medicine for the clinical application of Qigong therapy. […] CONCLUSIONS:: This study will provide reliable evidence-based evidence for the clinical application of Qigong in the treatment of COVID-19. | 2020-09-22 |
| 32957342 | Anxiety disorder places a heavy burden in the clinical treatment of patients of COVID-19. […] Acupuncture is a recommended treatment of COVID-19 in China, and clinical researches showed the effectiveness of acupuncture. | 2020-09-22 |
| 32957380 | The systematic review and meta-analysis aims to review and pool current clinical outcomes of CPM combined with routine western medicine (RWM) for the treatment of COVID-19. […] This study will provide evidence of CPM (including Jinhua Qinggan granule, Lianhua Qingwen capsule, and Xuebiqing injection) for the treatment on COVID-19 patients.INPLASY Registration number: INPLASY202050050. | 2020-09-22 |
| 32957405 | Exercise as a green and cheap complementary therapy, which has been proven to improve the immune capacity of the body and prevent infection. […] All randomized controlled trials of exercise therapy for COVID-19 in the above database will be considered for inclusion, and high-quality articles will be screened for data extraction and analysis, to summarize the therapeutic effect of exercise on COVID-19 patients. […] In this study, we hope to find strong evidence for the treatment of COVID-19 by exercise. | 2020-09-22 |
| 32957417 | Ribavirin of any dose or route will be compared with the control group of other medication, placebo, or no medication. […] The secondary outcome includes the hospital length of stay, ventilator-free days in 28 days, median time from start of study treatment to negative nasopharyngeal swab, and adverse events. […] The efficacy and safety of ribavirin for treatment of coronavirus-related pneumonia will be systematically reviewed and summarized. | 2020-09-22 |
| 32957696 | This non-invasive technique can offer multiple advantages in prophylaxis, as well as the prevention and treatment of severe epidemic respiratory syndrome with minimum risk and optimal therapeutic effects. […] This has the potential to create a novel pathway towards immunomodulatory therapy for the treatment of COVID-19 positive patients. | 2020-09-22 |
| 32957788 | Antiviral drug treatment has become another essential means to overcome pandemics in addition to vaccine development. | 2020-09-22 |
| 32957884 | The main challenge in this disease is the lack of proper or proven medication. […] The drugs used to treat this disease are only for symptomatic treatment. […] Therefore, the aim of this review was to scrutinize the potential of quercetin as a drug in the treatment of COVID-19 from a molecular perspective. | 2020-09-22 |
| 32957894 | Distinctive attention and exertions should be given to defending or reducing transmission in vulnerable populaces, including those directly associated with caregiving and treatment and also aged one. […] Passive antibody therapy is an additional alternate that purposes to use blood donors from hale and hearty people who have already recovered from COVID-19 and therapeutic advancement in handling COVID-19 pandemic. | 2020-09-22 |
| 32957905 | Although, the virus has caused a global public health concern, no effective treatment has been developed. | 2020-09-22 |
| 32957928 | The findings highlight the importance of understanding the transmission patterns of the common respiratory virus in COVID-19 regions, which can provide information support for the development of appropriate treatment plans and health policies, while eliminating unnecessary fear and tension. | 2020-09-22 |
| 32957995 | Although many instances of transmission of the SARS-CoV-2 have been reported, caution and further studies are necessary to avoid the occurrence of maltreatment in animals, and to achieve a better understanding of the dynamics of the disease in the environment, humans, and animals. | 2020-09-22 |
| 32957997 | Patients with increasing vascular risk factor burden have an increasing risk of severe COVID-19 disease, and this population might benefit from specific COVID-19 prevention (e.g., self-isolation) and early hospital treatment measures. | 2020-09-22 |
| 32958009 | While several repurposed antiviral and host-response drugs are under examination as potential treatments, other novel therapeutics are also being explored to alleviate the effects on critically ill patients. […] Successfully trialled for the treatment of other conditions such as multiple sclerosis, osteoarthritis and graft versus host disease, MSCs possess both regenerative and immunomodulatory properties, the latter of which can be harnessed to reduce the severity and longevity of ARDS in patients under intensive care due to SARS-CoV-2 infection. | 2020-09-22 |
| 32958069 | The second patient responded to the treatment over a period of 5 days. | 2020-09-22 |
| 32958120 | Combination therapy using chloroquine (CQ) and azithromycin (AZM) has drawn great attention due to its potential anti-viral activity against SARS-CoV-2. […] CQ treatment significantly increased the field potential duration, which corresponds to prolongation of the QT interval, and decreased the spike amplitude, spike slope, and conduction velocity of hESC-CMs. […] In support of the clinical data suggesting the cardiovascular side effects of the combination therapy of CQ and AZM, our results suggest that AZM reinforces the cardiotoxicity induced by CQ in hESC-CMs. | 2020-09-22 |
| 32958227 | The aim of this study is to analyze how the treatment of acute appendicitis has been affected. […] Highlight the contribution of this study in terms of knowledge of the status of the treatment of acute appendicitis during this first month of the pandemic, being able to serve for a better possible organization in future waves of the pandemic and a reorganization of current protocols and management of acute appendicitis in a pandemic situation. | 2020-09-22 |
| 32958495 | To find effective and safe treatments for COVID-19, the WHO recommended to systemically evaluate experimental therapeutics in collaborative randomised clinical trials. […] The objective of the trial is to evaluate the clinical efficacy and safety of different investigational re-purposed therapeutics relative to Standard of Care (SoC) in patients hospitalised with COVID-19. […] DisCoVeRy is a phase III, open-label, adaptive, controlled, multicentre clinical trial in which hospitalised patients with COVID-19 in need of oxygen therapy are randomised between five arms: (1) a control group managed with SoC and four therapeutic arms with re-purposed antiviral agents: (2) remdesivir + SoC, (3) lopinavir/ritonavir + SoC, (4) lopinavir/ritonavir associated with interferon (IFN)-β-1a + SoC and (5) hydroxychloroquine + SoC. […] This trial involves patients hospitalised in conventional departments or intensive care units both from academic or non-academic hospitals throughout Europe. | 2020-09-22 |
| 32958501 | Because of the lack of vaccination, it is urgent to find effective antiviral agents for COVID-19 treatment. […] HCQ treatment could shorten the body temperature recovery time (weighted mean difference = -1.04; 95% CI -1.64 to -0.45). […] Remdesivir treatment reduced the 14-day mortality rate of patients with severe COVID-19 (RR=0.64; 95% CI 0.44 to 0.94). […] HCQ, LPV/r and Arbidol bring little benefit in COVID-19 treatment. | 2020-09-22 |
| 32958531 | Immunosuppression induced by anticancer therapy in a COVID-19-positive asymptomatic patient with cancer may have a devastating effect and, eventually, be lethal. […] To identify asymptomatic cases among patients receiving active cancer treatment, the Federico II University Hospital in Naples performs rapid serological tests in addition to hospital standard clinical triage for COVID-19 infection. […] From 6 to 17 April 2020, all candidates for chemotherapy, radiotherapy or target/immunotherapy, if negative at the standard clinical triage on the day scheduled for anticancer treatment, received a rapid serological test on peripheral blood for COVID-19 IgM and IgG detection. […] In case of COVID-19 IgM and/or IgG positivity, patients underwent a real-time PCR (RT-PCR) SARS-CoV-2 test to confirm infection, and active cancer treatment was delayed. […] Moreover, it entailed additional economic and human resources, delayed therapy administrationand increased hospital accesses. | 2020-09-22 |
| 32958718 | Favipiravir is an oral broad-spectrum inhibitor of viral RNA-dependent RNA polymerase that is approved for treatment of influenza in Japan. […] We conducted a prospective, randomized, open-label, multicenter trial of favipiravir for the treatment of COVID-19 at 25 hospitals across Japan. […] Patients were randomly assigned at a 1:1 ratio to early or late favipiravir therapy (the same regimen starting on day 6 instead of day 1). […] Viral clearance occurred within 6 days in 66.7% and 56.1% of the early and late treatment groups (adjusted hazard ratio [aHR], 1.42; 95% confidence interval [95% CI], 0.76-2.62). […] Of 30 patients who had a fever (≥37.5°C) on day 1, time to defervescence was 2.1 days and 3.2 days in the early and late treatment groups (aHR, 1.88; 95%CI, 0.81-4.35). […] During therapy, 84.1% developed transient hyperuricemia. […] Neither disease progression nor death occurred to any of the patients in either treatment group during the 28-day participation (Japan Registry of Clinical Trials jRCTs041190120). | 2020-09-22 |
| 32958997 | Major forward leaps in data use, utilizing big data for research because traditional studies that take years were not options, predictive analytic functionality retooled to help predict COVID-19, deployment of testing and medication research trials at a super-sonic pace, design and launch of new telehealth care models, and exponential growth in Information Technology (IT) infrastructure were driven by the need to develop a ‘new normal’ for safe and effective care for all patients. | 2020-09-22 |
| 32959003 | A high rate of thrombotic complications, such as pulmonary embolism, has been linked to mortality in COVID-19, and appropriate treatment of thrombosis is important for lifesaving. […] Although systemic fibrinolytic therapy is a focus of attention because a thrombotic pathology is the cause of death in severe COVID-19, it should be kept in mind that fibrinolytic therapy might be harmful at advanced stage of COVID-19 where the status of disseminated intravascular coagulation (DIC) has been transmitted from suppressed-fibrinolytic to enhanced-fibrinolytic in disease progression of COVID-19. […] In this respect, inhalation therapy with fibrinolytic substances might be a safe and promising treatment. | 2020-09-22 |
| 32959008 | He was admitted in intensive care unit and managed with supportive treatment. | 2020-09-22 |
| 32959052 | Anti-CD20 monoclonal antibodies are widely used for the treatment of hematological malignancies or autoimmune disease but may be responsible for a secondary humoral deficiency. | 2020-09-22 |
| 32959148 | Unintended consequences might be delays in treatment for other diseases and subsequent mortality. | 2020-09-22 |
| 32959400 | Epidemiological, demographic, clinical, laboratory, radiological, treatment and clinical outcome data were collected, and predictors of the duration of viral shedding were explored through multivariable linear regression analysis. […] Multivariable linear regression analysis showed reducing viral shedding duration was associated with receiving recombinant human interferon alpha (rIFN-α) treatment, whilst the prolonged duration of viral shedding correlated with the use of glucocorticoid treatment, the durations from the first symptom to hospital admission and the improvement in chest computed tomography (CT) evidence. […] Glucocorticoid treatment and lymphocytes less than 1.1 × 109/L are associated with prolonged viral shedding. […] Early admission and rIFN-α treatment help shorten the duration of viral shedding. | 2020-09-22 |
| 32959495 | The Authors tried to identify the clinical phenotype that is most likely to benefit from anakinra treatment, in order to maximize utility and not to expose patients to unnecessary risks related to immunosuppression. | 2020-09-22 |
| 32959614 | Only 63% had correct knowledge about the role of antibiotics in COVID-19 treatment. | 2020-09-22 |
| 32959714 | Patient care often refers to the broad spectrum of care, prevention, and treatment that a provider delivers, while the point of a differential diagnosis is to make a distinction between 2 or more conditions that share similar signs or symptoms. […] As a result, newly formed hospital and clinical policies may have dangerously traded everyday diagnosis and treatment of patients for the pandemic and quarantine recommendations. | 2020-09-22 |
| 32959717 | Prone positioning is deployed as a critical treatment for improving oxygenation in patients with Acute Respiratory Distress Syndrome. | 2020-09-22 |
| 32959802 | However, bacterial coinfection rates increase in patients admitted in the intensive care units, and those diseases can be due to super-infections by nosocomial antibiotic-resistant bacteria. | 2020-09-22 |
| 32959869 | COVID-19 pandemic social distancing policies and ethical guidelines for COVID-19 treatment may exacerbate experiences of social isolation, perceived expendability, and exposure to suffering, which are related to the 3 main components of the Interpersonal Theory of Suicide (i.e., thwarted belongingness, perceived burdensomeness to society, and capability for suicide). […] Potential venues to increase treatment options and decrease social isolation are discussed. | 2020-09-22 |
| 32959883 | Interventions designed to limit the spread of COVID-19 are having profound effects on the delivery of healthcare, but data showing the impact on oncology clinical trial enrollment, treatment, and monitoring are limited. […] Nearly all patients on interventional treatment trials were maintained, and new enrollments continued at just under half the pre-pandemic rate. | 2020-09-22 |
| 32959892 | These findings demonstrate the broad-spectrum antiviral property of ivermectin benefiting for COVID-19 treatment in the context of predictive, preventive, and personalized medicine in virus-related diseases. | 2020-09-22 |
| 32959913 | With any new disease a framework for development of preventative or treatment therapeutics is key; the absence of such in COVID-19 has enabled ineffective and potentially unsafe treatments to be taken up by Governments and clinicians desperate to have options for patients. […] We describe a framework that has been used to prioritise therapeutic research in previous pandemics which could be used to progress clinical pharmacology and therapeutics research in COVID-19. […] This is particularly relevant as discussion has already moved on from antiviral therapeutics, to delineating the treatment of the host from treatment and elimination of the infective agent. […] Focussing on the host brings together three concepts; host treatment, the damage response framework and therapeutic repurposing. […] In integrating approaches to repurposing, host treatment and damage response we identified three key properties that a potentially effective repurposed drug must possess by way of a framework. […] To illustrate, we have mapped therapeutics that impact upon a key dysregulated pathway in COVID-19 - the renin angiotensin system- using this approach. | 2020-09-22 |
| 32959951 | We aim to provide a succinct review about the pathophysiology and cardiac manifestations of COVID-19, as well as treatment considerations and the various adaptations made to the current healthcare structure as a result of the pandemic. | 2020-09-22 |
| 32959998 | We report on a 48-year-old male COVID-19 patient with cardiogenic shock; despite extracorporeal life support, dialysis, and massive pharmacological support, this rescue therapy was not successful. | 2020-09-22 |
| 32960000 | Treatment of these patients require aerosolization procedures like nebulization and noninvasive modalities for ventilation like non-invasive ventilation (NIV) and high flow nasal cannula (HFNC). | 2020-09-22 |
| 32960061 | Currently there are no treatment options for it. | 2020-09-22 |
| 32960100 | In 2020, hydroxychloroquine (and to a lesser extent chloroquine) also received attention as a possible treatment for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). […] Evidence from COVID-19 treatment suggests QT/QTc prolongation is of concern, particularly when used in combination with azithromycin, although disagreement exists across studies. […] Dermatologic: Drug eruptions or rashes, followed by cutaneous hyperpigmentation, pruritis, Stevens-Johnson syndrome, and toxic epidermal necrolysis, may occur within days to weeks of exposure but usually resolve with the discontinuation of therapy. […] Chloroquine treatment of COVID-19 was associated with elevation in creatine kinase and creatine kinase-MB activities with more events in the higher-dose group. […] Hydroxychloroquine is a generally well-tolerated medication. | 2020-09-22 |
| 32960106 | Thrombo-inflammatory parameters provide key information on the severity and prognosis of COVID-19 and can be used as references for clinical treatment to correct inflammatory and coagulation abnormalities. | 2020-09-22 |
| 32960147 | Fifty-three patients received the approved COVID protocol without IFN treatment. | 2020-09-22 |
| 32960148 | Treatment of patients with a tracheostomy in the COVID-19 pandemic requires foresight and may rival procedural considerations in tracheostomy in their complexity. | 2020-09-22 |
| 32960167 | The impact of host adaptive immune response on COVID-19 has now become a critical issue in absence of specific therapy and immunotherapies. | 2020-09-22 |
| 32960639 | For this reason, the world’s leading nutrition societies and associations believe that nutritional therapy should be considered a part of the basic treatment of patients with COVID-19. | 2020-09-22 |
| 32960645 | Hopkins inHealth and COVID-19 Administrative Supplement for the HHS Region 3 Treatment Center from the Office of the Assistant Secretary for Preparedness and Response. | 2020-09-22 |
| 32960661 | Given the emerging literature reporting on the risk of QT prolongation and arrhythmias associated with COVID-19 disease and experimental therapies, we highlight some considerations for the prescribing of palliative care medications in this context. […] Based on the experience gained from palliative care referrals at our institution prior to and during the COVID-19 pandemic, and in collaboration with our clinical pharmacology colleagues, we outline some general prescribing principles which may assist with weighing the risks and benefits of prescribing symptomatic medications in and beyond the current pandemic. | 2020-09-22 |
| 32960880 | We evaluated associations between race/ethnicity and receipt of COVID-19 testing, a positive test result, and 30-day mortality, with multivariable adjustment for a wide range of demographic and clinical characteristics including comorbid conditions, health behaviors, medication history, site of care, and urban versus rural residence. | 2020-09-22 |
| 32960908 | Since the end of February 2020 a severe diffusion of COVID-19 has affected Italy and in particular its northern regions, resulting in a high demand of hospitalizations in particular in the intensive care units (ICUs). | 2020-09-22 |
| 32960938 | Many dental diagnosis and treatment procedures generate droplets and aerosols, and thus both dental staff and patients are at a high risk of becoming infected and transmitting COVID-19 to others. | 2020-09-22 |
| 32961123 | Hydroxychloroquine is generally considered safe in pregnancy for the treatment of rheumatic conditions, but studies have been too small to evaluate teratogenicity. […] Quantifying the risk of congenital malformations associated with early pregnancy exposure to hydroxychloroquine is important in both the context of its ongoing use for rheumatological disorders and its potential future use for coronavirus disease 2019 prophylaxis, for which a number of clinical trials are ongoing despite initial trials for coronavirus disease 2019 treatment having been negative. […] For most patients with autoimmune rheumatic disorders, the benefits of treatment during pregnancy will likely outweigh this risk. | 2020-09-22 |
| 32961245 | The incidence rates of in-hospital death among patients without AKI, with AKI not requiring kidney replacement therapy (AKI non-KRT) and with AKI receiving KRT (AKI-KRT) were 10.8, 31.1 and 37.5/1000 patient-days, respectively. | 2020-09-22 |
| 32961304 | Imposed restrictions and treatment precautions may have also influenced OHCA processes-of-care. | 2020-09-22 |
| 32961333 | Complement therapeutics have gained traction as candidate drugs for countering the detrimental consequences of SARS-CoV-2 infection. […] They also support the evaluation of these complement-targeting agents as COVID-19 therapeutics in large prospective trials. | 2020-09-22 |
| 32961360 | While initially preparing for a period of time, where it would likely be impossible to supervise trials in the usual way and precautionary measures had to be implemented to care for medication supply and general safety of study participants it is now important to consider, how the impact of the pandemic on trial outcome can be assessed, which measures are needed to decide, how to proceed with the trial and what is needed to compensate to irregularity introduced by the pandemic situation. […] Similarly not all clinical trials investigate vulnerable patient populations, but some will and may in addition have recruited to an extent that beneficial effects achieved in the initial phase of the trial may be outweighed by an increase e.g. in mortality that impacts both treatment groups. […] We discuss how simulations and theoretical considerations can be used to address questions about the need to increase the overall sample-size to be recruited to compensate for a potential shrinkage of the treatment effect caused by the COVID-19 pandemic and what role the degree of consistency could play when comparing pre-, during- and post- COVID-19 periods of trial conduct regarding the question, whether the treatment effect can be considered consistent and with this generalizable. […] This is dependent on the size of the treatment effect and the impact of the pandemic. | 2020-09-22 |
| 32961451 | In the initial LDCT a significantly higher FMR was found in patients requiring intensive care treatment within the follow-up period. […] In multivariate logistic regression analysis, FMR (p < .001) in addition to age (p < .01), was found to be a significant predictor of the necessity for ICU treatment of COVID-19 patients. […] Within the multivariate analysis, in addition to patient age, low muscle area in proportion to high fat area represents an additional prognostic information for the patient outcome and the need of an ICU treatment during the follow-up period within the next 22 days. […] This multicentric pilot study presents a method using an initial LDCT to screen opportunistically for obese patients who have an increased risk for the need of ICU treatment. | 2020-09-22 |
| 32961453 | Overall, 54.9 % were in opioid maintenance treatment (OMT). […] Drug treatment may play an important role in COVID-19 prevention, as those in OMT were more likely to be aware of symptoms and of availability of services. | 2020-09-22 |
| 32961636 | The most important policy to be implemented at the national level was securing national hospitals designated for the treatment of ID (67.4%). | 2020-09-22 |
| 32961675 | Our objective was to compare clinical protocols for the treatment of the novel coronavirus disease 2019 (COVID-19) among different hospitals in Andalusia, Spain. […] Antiviral treatment, empirical antibacterial agents, adjunctive therapies, anticoagulant treatment, supportive care, hospital organization, and discharge recommendations were analyzed. […] The recommended treatment for patients with mild and moderate pneumonias was different antiviral combinations including hydroxychloroquine plus azithromycin (93.3%) or hydroxychloroquine plus lopinavir/ritonavir (79.9%). […] Different combinations of hydroxychloroquine and lopinavir/ritonavir (46.7%) and triple therapy with hydroxychloroquine, azithromycin, and lopinavir/ritonavir (40%) were the most recommended treatments for patients with severe pneumonia. […] There were five corticosteroid regimens, which used dexamethasone, methylprednisolone, or prednisone, with different doses and treatment durations. […] This study showed that COVID-19 protocols varied widely in several aspects (antiviral treatment, corticosteroids, anakinra, and anticoagulation for high risk of thrombosis or critical situation). | 2020-09-23 |
| 32962148 | Co-infections can increase systemic inflammation influencing the prognosis and the severity of the disease, and can in turn lead to an increased need of mechanical ventilation, antibiotic therapy and to a higher mortality. | 2020-09-23 |
| 32962156 | However, no approved drug or vaccines are available, and treatment is mainly supportive and through a few repurposed drugs. | 2020-09-23 |
| 32962258 | Furthermore, 43.3% of the health professionals estimated that they might need psychological treatment in the future. | 2020-09-23 |
| 32962495 | This paper presents a short literature review to suggest a new treatment modality for COVID-19. | 2020-09-23 |
| 32962524 | Passive immunotherapeutics (PITs), including convalescent plasma, serum, or hyperimmune immunoglobulin, have been of clinical importance during sudden outbreaks since the early twentieth century for the treatment of viral diseases such as severe acute respiratory syndrome (SARS), middle east respiratory syndrome (MERS) and swine flu (H1N1). […] With the recent SARS-CoV-2 pandemic, wherein effective antivirals and vaccines are still lacking, an interest in convalescent plasma therapy as a lifesaving option has resurfaced due to its capacity for antigenic neutralization and reducing viremia. | 2020-09-23 |
| 32962613 | Besides drugs and vaccines, the role of convalescent plasma (CP) therapy to treat COVID-19 is also discussed. | 2020-09-23 |
| 32962623 | This review evaluates several published studies that have implemented Tocilizumab (TCZ), an IL-6 receptor antibody (US20120253016A1), in COVID-19 treatment. […] Interleukin6 (IL-6), a prominent inflammatory cytokine involved in CRS in various inflammatory conditions, may have a vital role in the underlying mechanism involved in debilitating SARS-CoV-2 infections and could serve as a viable treatment target. | 2020-09-23 |
| 32962639 | All 83 patients received antiviral treatment, 81(97.6%) deaths received antibiotic therapy, 54(65.1%) deaths received glucocorticoid therapy, and 20(24.1%) patients received invasive mechanical ventilation. | 2020-09-23 |
| 32962655 | We present two cases of confirmed COVID-19 patients and characterize their initial symptoms, chest CT results, medication, and laboratory test results in detail (including RT-PCR, IgM/ IgG, cytokine and blood cell counts). | 2020-09-23 |
| 32962731 | The etiology and antimicrobial resistance of bacteria were reported and used to provide a theoretical basis for appropriate infection therapy. | 2020-09-23 |
| 32962760 | Gastrointestinal symptoms are not rare among coronavirus disease 2019 (COVID-19) patients, but there have been no reports regarding convalescent plasma therapy for the recovery of gastrointestinal problems in COVID-19 patients. […] When COVID-19 patients develop recurrent or refractory gastrointestinal symptoms and fail to respond to the available treatment, alternative therapy with convalescent plasma administration may be considered. | 2020-09-23 |
| 32962848 | The purpose of this study was to describe the treatment of, and nursing care processes for, patients suspected, but not yet confirmed, of having coronavirus disease at 1 facility in Shanghai, China. […] Nurses need to understand the symptoms and treatment of the disease as well as nursing procedures, and learn how to cut off transmission routes, control transmission sources, and use protective equipment correctly to prevent transmission of the disease within the hospital. | 2020-09-23 |
| 32962867 | This study shows the possible exploration for drug repurposing using computer-aided docking tools and the potential roles of tipiracil and aprepitant, which can be explored further in the treatment of COVID-19. | 2020-09-23 |
| 32962902 | Large volumes of high-acuity patients, particularly those of advanced age and with chronic comorbidities, have significantly increased the need for palliative care resources beyond usual capacity. […] To meet the needs of COVID patients, services such as Emergency Medicine and Palliative Care have responded rapidly by adopting novel ways of practicing medicine. | 2020-09-23 |
| 32962996 | An inhalational treatment that safely prevents SARS-CoV-2 viral replication could be helpful for treating patients with pulmonary SARS-CoV-2 infection. | 2020-09-23 |
| 32963028 | The recent announcement that RECOVERY, a randomised controlled trial comparing dexamethasone to placebo in COVID-19, was terminated early due to excess deaths in the control group further suggests patients present with OP given that corticosteroid therapy is the first-line treatment. […] Although RECOVERY along with other cohort studies report positive effects with corticosteroids on morbidity and mortality of COVID-19, treatment approaches could be made more effective given that secondary OP often requires prolonged duration and/or careful and monitored tapering of corticosteroid dose, with ‘pulse’ doses needed for the well-described fulminant subtype. […] Increasing recognition of this diagnosis will thus lead to more appropriate and effective treatment strategies in COVID-19, which may lead to a further reduction of need for ventilatory support and improved survival. | 2020-09-23 |
| 32963133 | This study evaluated variations in the treatment of coronary artery disease according to time course of the COVID-19 pandemic in Japan.Methods and Results:The Japanese Association of Cardiovascular Intervention and Therapeutics performed serial surveys during the pandemic (in mid-April, late-April and mid-May 2020) with queries regarding the implementation of PCI. […] Hospitals were asked about their treatment strategies for elective PCI and emergency PCI for ST-elevation myocardial infarction (STEMI) and high-risk acute coronary syndrome (ACS) patients. […] The COVID-19 pandemic greatly affected PCI treatment in Japan. | 2020-09-23 |
| 32963155 | Treatment with tocilizumab (TCZ) to block interleukin-6 (IL-6) signalling is predicted to mitigate cytokine release syndrome (CRS) caused by coronavirus disease 2019 (COVID-19). […] Despite favipiravir treatment, acute respiratory distress syndrome developed in a 45-year-old patient with COVID-19; thus, TCZ was initiated. | 2020-09-23 |
| 32963215 | RESULTS A total of 158 cases were included according to COVID-19 diagnosis, and the treatment schemes were analyzed for identification of early indicators affecting COVID-19 progression. | 2020-09-23 |
| 32963216 | Effective anticoagulation therapy may play a dominant role in the management of severe COVID-19 cases. […] He received treatment including antibiotics, hydroxychloroquine, tocilizumab, vasopressors, prone positioning, and anticoagulation with enoxaparin at a prophylactic dose. […] CONCLUSIONS The presented COVID-19 case, one of the first reported cases with evidence of right heart thrombus by transesophageal echocardiography, highlights the central role of diagnostic imaging strategies and the importance of adequate anticoagulation therapy in the management of severe COVID-19 cases in the ICU. | 2020-09-23 |
| 32963228 | Treatment and prevention of these viral diseases call for the research and development of human neutralizing monoclonal antibodies (NMAbs). | 2020-09-23 |
| 32963239 | Establishing consensus around the transcriptional interface between coronavirus (CoV) infection and human cellular signaling pathways can catalyze the development of novel anti-CoV therapeutics. | 2020-09-23 |
| 32963417 | Nowadays, COVID-19 also known as novel coronavirus has become a global pandemic by causing severe respiratory tract infections in humans without any definite treatment or vaccine. | 2020-09-23 |
| 32963419 | Introduction and objectives Despite advances in treatment, patients with acute myocardial infarction (AMI) still exhibit unfavorable short- and long-term prognoses. | 2020-09-23 |
| 32963441 | Our experience about this virus and its epidemiology is limited, and mostly the treatment for symptomatic patients is supportive. | 2020-09-23 |
| 32963442 | Remdesivir has emerged as a promising molecule, based on results of clinical trials and observational studies and has receieved marketing approval for COVID-19 treatment under “emergency use authorization” in countries such as United States. | 2020-09-23 |
| 32963540 | Since then, the outbreak has grown into a global pandemic, and neither a vaccine nor a treatment for the disease, termed coronavirus disease 2019 (COVID-19), is currently available. […] In this context, this review explores the impact of bacteriophages on SARS-CoV-2, especially concerning phage therapy (PT). […] In this review, we hypothesize that the Ganges river may play a therapeutic role in the treatment of COVID-19. | 2020-09-23 |
| 32963563 | Lianhua Qingwen combined with conventional drugs may be a promising therapy for treating common pneumonia and COVID-19 pneumonia. | 2020-09-23 |
| 32963564 | However, there is currently no effective treatment available against SARS-CoV-2. | 2020-09-23 |
| 32963581 | The recent COVID-19 outbreak has increasingly engaged researchers in the search for effective antiviral drugs as well as therapeutic treatment options. | 2020-09-23 |
| 32963703 | H2 has shown anti-inflammatory and antioxidant ability in many clinical trials, and its application is recommended in the latest Chinese novel coronavirus pneumonia (NCP) treatment guidelines. […] This paper reviews the basic research and the latest clinical applications of H2 gas in multiorgan system diseases to establish strategies for the clinical treatment for various diseases. | 2020-09-23 |
| 32963819 | Several treatment strategies are currently under investigation for COVID-19, but none of them have been proved to be safe and effective to date. | 2020-09-23 |
| 32963823 | Patients’ characteristics (clinical, biological, and imaging) and treatment change induced by echocardiography were collected and analyzed. […] Patients with and without treatment change induced by echocardiography were compared. […] Echocardiography induced a treatment change in 9 cases (16%). […] The analyzed clinical data were not associated with any treatment change induced by echocardiography. […] D-dimer and Troponin levels were the only biological predictors of the induced treatment change. […] On echocardiography, higher systolic pulmonary arterial pressure and documented cardiac thrombi were associated with treatment changes in these patients. | 2020-09-23 |
| 32963831 | Nonsevere cases were described as mild, common type, nonintensive care unit (ICU) treatment, survivors, and severe cases as critical, need for ICU, refractory, and nonsurvivors. | 2020-09-23 |
| 32963854 | As no therapeutic guidelines on the subject are currently available, here we share our approach in the management of the immunosuppressive medications and the antiviral therapy and compare them to the scarce available data. | 2020-09-23 |
| 32963884 | The COVID-19 pandemic, which started in Wuhan, China, has spread rapidly over the world with no known antiviral therapy or vaccine. […] Sixty-five molecules from the ZINC database subset (AfroDb Natural Products) were virtually screened with some reported repurposed therapeutics against six SARS-CoV-2 and two human targets. | 2020-09-23 |
| 32963923 | The genome sequence of COVID-19 opened the opportunity for multiple in vitro and clinical trials, but we still do not have a clear path to treatment. […] We tested the virucidal potential of CPM in a nasal spray composition currently in development as an anti-allergy medication. | 2020-09-23 |
| 32964098 | Coronavirus Disease 2019 continues to spread and to date, no definitive treatment is available. […] In this article, we provide a brief overview of the protocol and then analyse the QT changes observed in a group of patients during their hospitalization and treatment for SARS-CoV-2 infection. 81 patients with confirmed SARS-CoV-2 infection were enrolled in the protocol (age 63.4 SD 17.2 years; 70.3% men), while being treated with lopinavir/ritonavir, azithromycin and hydroxychloroquine, both individually or combined. […] Ten patients developed long drug-related QT interval, and the QT prolongation was statically significant for all treatment schemes. | 2020-09-23 |
| 32964337 | D-dimer and IL-6 determinations, ICU admission, and previous antithrombotic treatment were registered. | 2020-09-23 |
| 32964535 | In a real-world setting, HCQ/CQ treatment is associated with higher reporting rates of various CVAEs, particularly cardiomyopathy, QT prolongation, cardiac arrhythmias and heart failure. | 2020-09-23 |
| 32964827 | It has become the need of the hour to understand the pathophysiology of this disease, so that drugs, vaccines, treatment regimens and plausible therapeutic agents can be produced. […] Synthetic feasibility, equipotent binding and very low toxicity of this peptide nucleic acid derived compounds can serve as a leading scaffold to design, synthesize and evaluate many of similar compounds for the treatment of COVID-19. | 2020-09-23 |
| 32964913 | We systematically reviewed the literature to answer the following research questions: 1) does IL-6 (receptor) antagonist therapy reduce mortality in COVID-19 patients compared to patients not treated with IL-6 (receptor) antagonists and 2) is there an increased risk of side effects in COVID-19 patients treated with IL-6 (receptor) antagonists compared to patients not treated with IL-6 (receptor) antagonists?. | 2020-09-23 |
| 32964930 | Extracorporeal membrane oxygenation (ECMO) is a supportive therapy option for selected severely ill patients who deteriorate despite the best supportive care. | 2020-09-23 |
| 32965007 | These patients require a high index of clinical suspicion and an accurate diagnostic approach, in order to immediately start an appropriate anticoagulant treatment. | 2020-09-23 |
| 32965013 | Several management options have been suggested and have since gained popularity, though we expect additional modifications to be made, as well as more new cases in the coming months, given a lack of definitive treatment and well-controlled experiments. […] The following terms were used: “COVID-19,” “SARS-CoV-2,” “drug,” “treatment,” “medication,” and “management.” […] However, we do not have a definitive and specific treatment yet. […] Therefore, further research is needed to characterize the disease behavior, to find the absolute drug, and to refine the treatment. | 2020-09-23 |
| 32965014 | The 3 SARS-CoV-2 infected patients were clinically diagnosed as COVID-19 because they meet the diagnostic criteria listed in “Chinese Clinical Guidance for COVID-19 Pneumonia diagnosis and treatment”, including epidemic history, symptom and pathogenic detection, as well as abnormalities of the laboratory and radiological data. | 2020-09-23 |
| 32965015 | SARS-CoV-2 can reportedly exist on inanimate surfaces for a long duration, but there is limited data available from Italian COVID-19 hospital wards, especially for non-intensive care units hosting patients that do not require mechanical ventilation. | 2020-09-23 |
| 32965018 | Unfortunately, its treatment is yet to be developed. | 2020-09-23 |
| 32965269 | ; The quality of the diagnostic and treatment process is characterized by many quantitative indicators. | 2020-09-23 |
| 32965350 | Inflammatory changes are part of COVID-19 pathophysiology and this might generate a higher thromboembolic risk in patients using combined hormonal contraception and menopausal hormone therapy. […] This narrative review collected information from several articles published since the beginning of the outbreak of the new coronavirus disease about the pathophysiology, stage of the disease, the occurrence of thrombotic events, and the risk of thromboembolism in users of contraception and hormonal therapy. […] This article consolidates clinical parameters about the risk of venous thromboembolism in users of contraception and menopausal hormone therapy emphasizing the probable increase of that risk in women with suspected or confirmed COVID-19 and bringing safer recommendations. […] In this scenario, apart from the fundamental orientations of preventive measures, like social isolation and hygiene, it is important that all female health professionals have knowledge of the new rules and adopt safety measures, especially on the prescription of hormonal therapy and contraception. | 2020-09-23 |
| 32965356 | Interestingly, a few patients with COVID-19-induced acute fulminant myocarditis were steroid-responsive and had an amelioration with glucocorticoid and immunoglobulin therapy. | 2020-09-23 |
| 32965359 | This study aims to evaluate changes in hematological parameters after the follow-up of patients who received treatment with favipiravir due to COVID-19 infections. […] Sixty-two cases receiving favipiravir treatment for at least five days due to COVID-19 infection were evaluated retrospectively. […] Hematologic parameters were analyzed before and after the treatment. […] The mean age of the patients receiving treatment with favipiravir was 63.7±12.3 years. […] In the statistical analysis of the hematological parameters before and after treatment with favipiravir, WBC, PT-PTT-INR levels were found to be unaffected; the mean RBC was found to have decreased from 4.33 ± 0.58 M/uL to 4.16 ± 0.54 M/uL (p:0.003); the median hemoglobin level was found to have decreased from 12.3 g/dl to 11.9 g/dl (p:0.041); the hematocrit level decreased from 38.1% ± 4.8 to 36.9% ± 4.2 (p:0.026); the median neutrophil count decreased from 4.57 K/uL to 3.85 K/uL (p:0.001); the mean lymphocyte count increased from 1.22 ± 0.53 K/uL to 1.84 ± 1.19 K/uL (p:0.000); and the mean platelet count increased from 244.1 ± 85.1 K/uL to 281.9 ± 103.3 K/uL (p:0.005). […] We concluded that the pathological effect of treatment with favipiravir on the hematologic system was the suppression in the erythrocyte series, and there were no adverse effects in other hematologic parameters. | 2020-09-23 |
| 32965360 | The use of these agents should be maintained for the treatment of hypertension during hospitalization. | 2020-09-23 |
| 32965363 | The ages, genders, chronic diseases, ABO and Rh blood group antigens, admission rates to Intensive Care Units (ICU), and mortality rates of the patients were analyzed. | 2020-09-23 |
| 32965369 | The aim of this rapid systematic review is to analyze the prevalence of clinical, socioeconomic, and demographic characteristics, laboratory and imaging findings, diagnostic tests, and treatment information of older adults with COVID-19. | 2020-09-23 |
| 32965455 | Statins could potentiate the ASA therapy. […] All patients underwent the ASA therapy. […] Those who had risk factors for vascular disease also underwent the high-potency statin therapy. […] As this was a case series, we cannot provide definitive conclusions; however, this study allows us to formulate hypotheses and support clinical trials to evaluate benefits of the ASA therapy in the treatment of COVID-19. | 2020-09-23 |
| 32965456 | However, controversial issues such as the timing and pathways of viral emergence, the effectiveness of social distancing and lockdown strategies, and the use of antimalarial drugs as therapy have still not been fully resolved. | 2020-09-23 |
| 32965457 | The areas of research interest were also identified in the funding documents; the most common topic was “diagnosis” and the least common was “equipment for treatment.” | 2020-09-23 |
| 32965501 | Elevated RDW at the time of hospital admission and an increase in RDW during hospitalization were associated with increased mortality risk for patients with COVID-19 who received treatment at 4 hospitals in a large academic medical center network. | 2020-09-23 |
| 32965502 | Identifying independent risk factors for adverse outcomes in patients infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can support prognostication, resource utilization, and treatment. | 2020-09-23 |
| 32965509 | While the current definition, pathophysiology and differential diagnoses were previously addressed in this journal, this article focuses on some specific and individualized treatment options. […] Ventilation treatment with limitation of tidal volumes and pressure amplitudes has been shown to be advantageous with respect to mortality. […] Therefore, an individualized treatment should consider these issues and take the characteristics of the patient and the specific disease progression into account. | 2020-09-23 |
| 32965525 | Seizures could be induced by hydroxychloroquine that was in the COVID-19 treatment or the inflammation caused by COVID-19 pneumonia. | 2020-09-23 |
| 32965603 | Relevant clinical and laboratory variables were recorded, focusing on the type of current anti hypertensive treatment. […] Distribution of antihypertensive treatment was: ACEIs 77/221 (35%), ARBs 63/221 (28%), OTHER than ACEIs or ARBs 64/221 (29%). […] In 17/221 (8%) antihypertensive medication was unknown. | 2020-09-23 |
| 32965662 | The results of 2 studies showed no association between delayed radical prostatectomy(RP) and adverse oncological outcomes, supporting current recommendations of urologic societies for surgical treatment of patients with intermediate- and high-risk prostate cancer during the coronavirus disease 2019 (COVID-19)pandemic. | 2020-09-23 |
| 32965715 | The role of convalescent plasma therapy for patients with coronavirus disease 2019 (COVID-19) is unclear. […] In severe COVID-19, convalescent plasma therapy was not associated with clinical benefits. | 2020-09-23 |
| 32966166 | Whether PCT may be used for detecting secondary bacterial infections and guiding antibiotic therapy in COVID-19 is still undefined. | 2020-09-23 |
| 32966283 | The concurrent circulation of dengue and coronavirus disease 2019 (COVID-19) may produce many unfavourable outcomes-such as co-infections; delays in diagnosis, treatment, and mitigation measures; overwhelming of the healthcare system; underreporting of cases; deterioration in surveillance and control interventions; and exacerbation of social inequalities. | 2020-09-23 |
| 32966814 | In conclusion, our findings demonstrate that AR12 represents a clinically relevant anti-viral drug for the treatment of SARS-CoV-2. | 2020-09-23 |
| 32966970 | Dexamethasone, a synthetic glucocorticoid, has emerged as a life-saving treatment in severe COVID-19. […] This review will examine the endocrine mechanisms that control ACE2 and discusses the impact of therapies targeting the RAAS, glucocorticoid and other endocrine systems for their relevance to the impact of SARS-CoV-2 infection and the treatment and recovery from COVID-19-related critical illness. | 2020-09-23 |
| 32967163 | Events about the development of COVID-19 remained hot, but generally declined, and public attention shifted to other aspects of the epidemic (e.g., encouragement, support, and treatment). | 2020-09-24 |
| 32967229 | Although immune checkpoint therapy has been successfully used in cancer treatment, numerous studies have suggested that such therapy may also be highly relevant for treating viral infection, especially chronic viral infections. […] Here, we reviewed recent findings regarding immune checkpoints in viral infections, including COVID-19, and discussed the role of immune checkpoints in different viral infections, as well as the potential for applying immune checkpoint blockades as antiviral therapy. | 2020-09-24 |
| 32967358 | Since currently no resolutive therapy for ARDS has been found and given the scientific literature regarding the use of adenosine, its application has been hypothesized. | 2020-09-24 |
| 32967465 | We proposed a treatment priority levels and timings; the “High” priority level includes all monocular patients; the “Moderate” is assigned to all patients with an active macular neovascularization; the patients affected by diabetic macular edema or retinal vein occlusion belong to the “Low” class. | 2020-09-24 |
| 32967466 | The scientific community has put in much effort and published studies that described COVID-19’s biology, transmission, clinical diagnosis, candidate therapeutics, and vaccines. | 2020-09-24 |
| 32967717 | The primary outcomes will be changes in mental health conditions (e.g., depression, anxiety, stress, quality of life), behavioral health conditions (e.g., substance use, smoking, sexual behavior, eating behavior, medication adherence), and physical health conditions (e.g., coping with cancer, menopausal symptoms, arthritis pain). | 2020-09-24 |
| 32967849 | Clinical trials and advanced practice should immediately pivot to combination/sequential drug therapy for ambulatory COVID-19 illness. | 2020-09-24 |
| 32967853 | Regarding pharmacotherapy for mental health symptoms and disorders, some important aspects of management have changed during the pandemic, particularly for certain classes of medication including stimulants, medications for bipolar and psychotic disorders, antidepressants and medications for substance use disorders. | 2020-09-24 |
| 32967892 | We considered psychological distress, quarantine status, social distancing and self-medication in China and the UK. […] Risk of SMI was positively associated with self-medication (βs=0.17, p=0.001) and negatively with social distancing in China (country×SMI β=0.51, p=0.001), with further interactions for age and sex (social distancing), age, marital status and quarantine (self-medication). […] Across the countries, quarantine was associated with poorer mental health, while greater psychological distress was associated with greater self-medication rate. | 2020-09-24 |
| 32968208 | Chloroquine phosphate and its derivative hydroxychloroquine, which have been used in the treatment and prevention of malaria and autoimmune diseases for decades, were found to inhibit SARS-CoV-2 infection with high potency in vitro and have shown clinical and virologic benefits in COVID-19 patients. […] Therefore, chloroquine phosphate was first used in the treatment of COVID-19 in China. […] From pharmacological and cardiovascular perspectives, therefore, the treatment of COVID-19 with chloroquine and its derivatives should be systematically evaluated, and patients should be routinely monitored for cardiovascular conditions to prevent lethal adverse events. | 2020-09-24 |
| 32968307 | All patients received loop diuretics, 97.2% beta-blockers, 64.9% an aldosterone antagonist, 60.9% sacubitril/valsartan (S/V), and 72.2% of the remaining patients were on angiotensin-converting enzyme inhibitor or valsartan therapy. […] Patients were contacted by phone during and at the end of the lockdown period to fix a new appointment and underwent a structured interview to assess their clinical conditions and ongoing therapy and to verify whether they had contracted SARS-CoV-2 infection. […] None was hospitalized for worsening heart failure or reported defibrillator shocks and none changed autonomously the prescribed therapy. […] Cancellation of scheduled follow-up visits during 3 months did not have significant negative effects in a cohort of stable patients with chronic heart failure on optimized medical therapy. […] Telephone support was effective in keeping connections with the patients during the lockdown, allowing appropriate management and implementation of drug therapy. […] In particular, patients who received S/V were not affected by delays in scheduled visits, confirming the tolerability and safety of this novel therapy in terms of both clinical and biohumoral parameters. | 2020-09-24 |
| 32968416 | From January to March 2020, COVID-19 patients were divided into two groups according to the Diagnosis and Treatment Protocol for Novel Coronavirus Pneumonia (trial version 7), with mild and ordinary cases as Group-1 and critical and severe cases as Group-2. […] After treatment, the CT scan results became normal. […] The indices may play predictive roles in clinical treatment and prognosis evaluation. | 2020-09-24 |
| 32968429 | Outcomes recorded included time interval between most recent anti-cancer treatment and admission, severe outcome [a composite endpoint of intensive care unit (ITU) admission, ventilation and/or death] and mortality. […] Cancer patients who received systemic treatment within 28 days had an OR for mortality of 4.05 (95% CI 0.68-23.95), p = 0.12. | 2020-09-24 |
| 32968487 | With a scientific background from filoviruses, paramyxoviruses, SARS-CoV, and MERS-CoV, remdesivir entered into the COVID-19 battle to become one of the favorable therapeutic candidates with potential antiviral activity in the treatment of this disease. | 2020-09-24 |
| 32968582 | Despite aggressive treatment with steroids, tocilizumab and other supportive measures, the patient died of cardiac arrest. | 2020-09-24 |
| 32968602 | The directives for the management of COVID-19 have been limited to infection control measures and treatment of patients, which has left physicians and researchers alone to navigate the massive amount of research being published while searching for evidence-based strategies to care for patients. | 2020-09-24 |
| 32968604 | Local safety net health care resources were struggling with the increase in emergency room utilization and scrambled to increase patient care capacity, especially their emergency rooms and intensive care units. | 2020-09-24 |
| 32968643 | According to published data, we summarized the clinical manifestations of myocardial injury in COVID-19 patients, and discussed the probable injury mechanism, treatment methods and future research directions. | 2020-09-24 |
| 32968645 | Thus, this case elucidates new treatment measures for COVID-19. | 2020-09-24 |
| 32968646 | Selection of specific antiplatelet therapy in an uncomplicated post percutaneous coronary intervention (PCI) patient can, at times, be crucial issue in such strained circumstances. […] Potent P2Y12 inhibitor based dual antiplatelet therapy might have prevented this subacute ST, and thus mortality, as the patient was discharged on clopidogrel after PCI. | 2020-09-24 |
| 32968669 | Till now, there is no specific treatment or vaccine available; hence timely-taken preventive measures are the only hope that can save the people of this region. | 2020-09-24 |
| 32968954 | In the absence of characterization on pharmacokinetics and reference concentrations for hydroxychloroquine in COVID-19 patients, the dose and treatment duration for hydrochloroquine are currently empirical, mainly based on in vitro data, and may vary across national guidelines and clinical study protocols. | 2020-09-24 |
| 32969125 | It is now being investigated as a potential candidate treatment for SARS-CoV-2 having been identified as a candidate therapeutic for this virus by both in vitro and in silico drug screens. | 2020-09-24 |
| 32969188 | Besides the established general recommendations (physical distance, surgical masks, gloves, etc.), we established specific recommendations that will allow patient treatment and relieve the disruption of the immune response. | 2020-09-24 |
| 32969318 | Providing resources for families, encouraging parental self-care, educating families about online safety, and encouraging family discussion about child abuse all help to prevent abuse and maltreatment of children. | 2020-09-24 |
| 32969340 | Approximately one-third of the participants (44/154, 28.6%) suggested preferred functionalities and characteristics of mobile mental health care apps, such as affordable price, simple design, ease of use, web-based therapy, communication with others experiencing the same issues, and tracking of mental status. […] Improving the digital health literacy of university students in the UAE by increasing their awareness of mental health care apps and the treatment methods and benefits of the apps, as well as involving students in the app creation process, may encourage students to use these tools for mental health care. | 2020-09-24 |
| 32969367 | This study was designed to investigate effects of angiotensin-converting enzyme inhibitors (ACEIs) or angiotensin II receptor blockers (ARBs) on clinical outcomes of COVID-19 patients and to assess the safety of ACEIs/ARBs medication. […] MATERIAL AND METHODS COVID-19 patients with hypertension from 2 hospitals in Wuhan, China, from 17 Feb to 18 Mar 2020 were retrospectively screened and grouped according to in-hospital medication. | 2020-09-24 |
| 32969369 | Ever since the COVID-19 pandemic started scientists, researchers, universities, companies, and institutions all around the world have been endeavoring to discover a potential treatment for COVID-19. […] Numerous studies and clinical trials on vaccines and drugs for the prevention and treatment of COVID-19 are underway across the world. […] However, the uncertainty around the efficacy and safety of various treatment regimens have become one of the biggest challenges in the battle against the SARS-CoV-2. […] There are ongoing clinical trials on potential drugs such as remdesivir, favipiravir, lopinavir/ritonavir, chloroquine, and hydroxychloroquine, corticosteroids tocilizumab, azithromycin, anakinra, etc. and other therapeutic modalities like convalescent plasma therapy. […] Keywords: COVID-19; antiviral drugs; COVID-19 treatment; COVID-19 vaccine; SARS-CoV-2. | 2020-09-24 |
| 32969524 | Antiviral therapy against SARS-CoV-2 is still lacking. | 2020-09-24 |
| 32969557 | Treatment of this condition may include immunosuppressive therapies, such as IL-6 receptor antagonists and corticosteroids, which pose a risk for patients with active or past hepatitis B virus (HBV) infection. […] In this prospective cohort study, we analysed the risk of HBV reactivation in patients with severe COVID-19 and resolved HBV infection undergoing immunosuppressive therapy. […] Our data show that the risk of HBV reactivation in patients with severe COVID-19 and resolved HBV infection undergoing immunosuppressive treatment is low. | 2020-09-24 |
| 32969629 | In the next future, dermatologists, endocrinologist and physicians may cope with the impact of extent SARS-CoV-2 (COVID 19) infection over chronic inflammatory skin diseases and their treatment. | 2020-09-24 |
| 32969967 | In 44.4% of the cases, the PM&R physician prescribed medication to the patient and in 21.6% of the cases either an injection or radiofrequency ablation was ordered. […] This was especially notable with follow-up visits where imaging and treatment plan can easily be discussed over telemedicine. | 2020-09-24 |
| 32970329 | Viral genome mutations exist commonly which may impact the encoded proteins, possibly resulting to varied effectivity of detection tools and disease treatment. […] These findings suggest that the virion’s genotype and phenotype in a specific population should be considered in developing diagnostic tools and treatment options. | 2020-09-24 |
| 32970490 | Office blue laser TNFLS is safe and effective in the treatment of RRP and a range of benign laryngeal lesions. […] Future research should compare the efficacy and safety of blue laser with potassium titanyl phosphate laser in office-based treatment of these conditions. | 2020-09-24 |
| 32970512 | On the basis of our review and personal experience, we have outlined opportunities for telehealth to play a role in every step of the cancer care journey from diagnosis to therapy to surveillance to clinical trials for medical, surgical, and radiation oncology. | 2020-09-24 |
| 32970542 | With the COVID-19 pandemic threatening millions of lives around the world with no clear promises for treatment or vaccine yet, motivating the public to change their behaviors to prevent the spread of the disease becomes crucial and moral imperative. | 2020-09-24 |
| 32970560 | The unprecedented COVID-19 pandemic has resulted in rapidly evolving best practices for transmission reduction, diagnosis, and treatment. | 2020-09-24 |
| 32970653 | Hence, early evaluation of abdominal vessels in covid-19 patients who present with any abdominal symptoms should be considered, especially when found to have an elevated D-dimer level, as early treatment of thrombosis with low-molecular-weight heparin can have a significant impact on the therapeutic outcome. | 2020-09-24 |
| 32970753 | Close monitoring of the T cell subsets might provide valuable information of the patient’s condition change during the treatment process. | 2020-09-24 |
| 32970774 | Rates of complications such as cardiogenic shock and cardiopulmonary resuscitation, treatment escalations (thrombolysis for PE), and mortality were analyzed by patient chart review during 6 weeks following onset of COVID-19 associated RM, and during respective time frames in the years 2016 to 2019. 1,668 patients were included. […] PE patients received more frequently thrombolysis treatment (RR 3.63; p = 0.006), while rates of cardiogenic shock and cardiopulmonary resuscitation remained unchanged. | 2020-09-24 |
| 32970973 | These restrictions on social interactions can be especially problematic for individuals managing or recovering from addiction given that treatment often involves access to services and resources that became limited or even unavailable at this time. | 2020-09-24 |
| 32970974 | Exosomes have been demonstrated that they can be applied in identification and treatment of multiple disorders such as cancers, cerebral ischemia, and respiratory infectious diseases. […] Importantly, researchers utilize application of exosomes in the treatment of various respiratory infectious diseases that have made some breakthrough progress. […] In this review, we explain the use of exosomes in various respiratory infectious diseases and their serious complications, and hope to provide new ideas for the treatment of new coronavirus infections. | 2020-09-24 |
| 32971006 | Using an established set of spatiotemporal Bayesian geostatistical models, we generated geospatial estimates across malaria-endemic African countries of the clinical case incidence and mortality of malaria, incorporating an updated database of parasite rate surveys, insecticide-treated net (ITN) coverage, and effective treatment rates. […] We established a baseline estimate for the anticipated malaria burden in Africa in the absence of COVID-19-related disruptions, and repeated the analysis for nine hypothetical scenarios in which effective treatment with an antimalarial drug and distribution of ITNs (both through routine channels and mass campaigns) were reduced to varying extents. […] With greater reductions in access to effective antimalarial drug treatment, our model predicted increasing numbers of cases and deaths: 224·1 (148·7-326·8) million cases and 487·9 (385·3-634·6) thousand deaths with a 25% reduction in antimalarial drug coverage; 233·1 (153·7-342·5) million cases and 597·4 (468·0-784·4) thousand deaths with a 50% reduction; and 242·3 (158·7-358·8) million cases and 715·2 (556·4-947·9) thousand deaths with a 75% reduction. | 2020-09-24 |
| 32971089 | There are couples of treatment methods for COVID-19, however, well-established drugs and vaccines are urgently needed to treat the COVID-19. […] The identified drugs should be further evaluated in molecular level wet-lab experiments in prior to clinical studies in the treatment of COVID-19. | 2020-09-24 |
| 32971109 | We analyzed plasma levels of myeloperoxidase (a marker of neutrophil activation), soluble (s) CD25 (sCD25) and soluble T-cell immunoglobulin mucin domain-3 (sTIM-3) (markers of T-cell activation and exhaustion), and sCD14 and sCD163 (markers of monocyte/macrophage activation) in 39 COVID-19-infected patients at hospital admission and 2 additional times during the first 10 days in relation to their need for intensive care unit (ICU) treatment. […] Our major findings were as follows: (1) severe clinical outcome (ICU treatment) was associated with high plasma levels of sTIM-3 and myeloperoxidase, suggesting activated and potentially exhausted T cells and activated neutrophils, respectively; (2) in contrast, sCD14 and sCD163 showed no association with need for ICU treatment; and (3) levels of sCD25, sTIM-3, and myeloperoxidase were inversely correlated with degree of respiratory failure, as assessed by the ratio of Pao2 to fraction of inspired oxygen, and were positively correlated with the cardiac marker N-terminal pro-B-type natriuretic peptide. […] Our findings suggest that neutrophil activation and, in particular, activated T cells may play an important role in the pathogenesis of COVID-19 infection, suggesting that T-cell-targeted treatment options and downregulation of neutrophil activation could be of importance in this disorder. | 2020-09-24 |
| 32971147 | There is no specific drug or vaccine targeting SARS-CoV-2 currently and only symptomatic treatment is being administered, but several antivirals are under active investigation. | 2020-09-24 |
| 32971210 | Although some current therapeutic agents have showed potential prevention or treatment, a growing number of associated adverse events have occurred on patients with COVID-19 in the course of medical treatment. […] Overall, this study provides forceful approaches to assess potential side effects on COVID-19 drugs, which will be helpful for their safe use in clinical practice and promoting the discovery of antiviral therapeutics against SARS-CoV-2. | 2020-09-24 |
| 32971254 | The main exposure variable was corticosteroid therapy at a dose of ≥0.5 mg/kg of prednisone equivalents. […] It was introduced as binomial covariate in a logistic regression model for the primary endpoint and inverse probability of treatment weighting using the propensity score. […] At multivariable analysis corticosteroid treatment was not associated with lower 30-day mortality rate (adjusted odds ratio, 0.59; 95% confidence interval (CI), 0.20-1.74; p 0.33). […] After inverse probability of treatment weighting, corticosteroids were not associated with lower 30-day mortality (average treatment effect, 0.05; 95% CI, -0.02 to 0.09; p 0.12). […] However, subgroup analysis revealed that in patients with PO2/FiO2 < 200 mm Hg at admission (135 patients, 52 (38%) treated with corticosteroids), corticosteroid treatment was associated with a lower risk of 30-day mortality (23/52, 44% vs. 45/83, 54%; adjusted odds ratio, 0.20; 95% CI, 0.04-0.90; p 0.036). […] The effect of corticosteroid treatment on mortality might be limited to critically ill COVID-19 patients. | 2020-09-24 |
| 32971511 | This retrospective study was conducted among 32 patients with COVID-19 and T1D, who sought treatment at the Prince Sultan Military Medical City, Riyadh, Saudi Arabia between May 01, 2020 and July 30, 2020. […] Majority of the COVID-19 patients with T1D recovered with conservative treatment at home. | 2020-09-24 |
| 32971536 | The aim of the study was to describe ECG modifications and arrhythmic events in COVID-19 patients undergoing hydroxychloroquine (HCQ) therapy in different clinical settings. […] COVID-19 patients at seven institutions receiving HCQ therapy from whom a baseline and at least one ECG at 48+ h were available were enrolled in the study. […] QT/QTc prolongation, QT-associated and QT-independent arrhythmic events, arrhythmic mortality, and overall mortality during HCQ therapy were assessed. […] HCQ therapy was administrated as a home therapy regimen in 126 (19.4%) patients, and as an in-hospital-treatment to 495 (76.3%) hospitalized and 28 (4.3%) intensive care unit (ICU) patients. […] The overall major ventricular arrhythmia rate was low (1.1%), with all events found not to be related to QT or HCQ therapy at a centralized event evaluation. […] HCQ administration is safe for a short-term treatment for patients with COVID-19 infection regardless of the clinical setting of delivery, causing only modest QTc prolongation and no directly attributable arrhythmic deaths. | 2020-09-24 |
| 32971906 | The scientific community is exerting an extraordinary effort to elucidate all aspects related to SARS-CoV-2, such as the structure, ultrastructure, invasion mechanisms, replication mechanisms, or drugs for treatment, mainly through in vitro studies. | 2020-09-25 |
| 32972027 | Repositioning existing drugs such as Hydroxychloroquine, Remdesivir, Ivermectin and Baricitinib shows good potential for COVID-19 treatment. […] This review discusses the past success in drug repositioning, the current technological advancement in the field, drug repositioning for personalised medicine and the ongoing research on newly emerging drugs under consideration for the COVID-19 treatment. | 2020-09-25 |
| 32972125 | The recommendations included preventive measures against COVID-19, medicinal treatment for stable or active SRD patients without COVID-19, medicinal treatment for SRD patients with COVID-19, and patient evaluation and monitoring. […] These recommendations should serve as a reference for individualized treatment for patients with SRD. | 2020-09-25 |
| 32972126 | There is now a general consensus on the recommendation of anticoagulation in patient with severe SARS-Cov2 infections, although the dose of the prophylaxis and even the choice between a prophylactic and a treatment regimen remains controversial. | 2020-09-25 |
| 32972153 | Lack of effective treatment, coupled with etiology of COVID-19, has resulted in more than 500,000 confirmed deaths at the time of writing, and the global economy is at an unseen unprecedented low level with unknown near- and long-term consequences. […] The molecule was originally designed for the prophylaxis and treatment of flu caused by both Influenza A and B viruses and for the treatment of viral causes of acute respiratory illness. | 2020-09-25 |
| 32972176 | The issue of hypertension/antihypertensive treatment in patients with COVID-19 infection is discussed in the commentary. | 2020-09-25 |
| 32972177 | This approach can be used in different patients according to their treatment strategies and individual abilities. | 2020-09-25 |
| 32972202 | Telepsychotherapy, until now a promising but niche treatment, has suddenly become treatment as usual. […] This article briefly reviews the limited clinical evidence supporting different modes of telepsychotherapy, then focuses on how remote therapy affects clinicians and their patients. | 2020-09-25 |
| 32972235 | Although a recent report indicated favorable responses to the interleukin-1 receptor antagonist, anakinra in eight patients with COVID-19 secondary HLH diagnosed using the HScore calculation, others have suggested that the diagnosis of secondary HLH is uncommon and that the use of the HScore has limited value in guiding immunomodulatory therapy for COVID-19. | 2020-09-25 |
| 32972277 | China is currently conducting several clinical trials on MSCs for the treatment of COVID-19. | 2020-09-25 |
| 32972300 | Given the critical importance to continue chemotherapy, there remains additional interventions to further enhance patient safety while conserving healthcare resources such as adjustments in medication administration, reduction in laboratory or drug monitoring, and home delivery of specialty infusions. | 2020-09-25 |
| 32972313 | This pilot study evaluated the perceived effectiveness and usability of Mindset, a novel mobile app that monitors user stress level via heart rate to encourage e-therapy use. | 2020-09-25 |
| 32972320 | Albeit the strong thrombotic tendency in Covid-19 infections, the presence of frequent acquired thrombophilia may be part of the inflammation storm of Covid-19 disease and should not systematically modify our strategy on prophylactic anticoagulant treatment which is already revised upwards in this pathology. | 2020-09-25 |
| 32972339 | In the absence of definitive therapy, symptomatic management remains the standard of care. | 2020-09-25 |
| 32972360 | Outcomes included demographic variables, change in migraine frequency and severity during the lockdown period, communication with treating physician, compliance to migraine treatment, difficulty in getting medications, medication overuse, symptoms of anxiety and/or depression, sleep and eating habits disturbance, screen time exposure, work during pandemic, use of traditional medicine, effect of Botox injection cancellation, and overall worries and concerns during pandemic. […] The majority of respondents; 626 (61.5%) did not communicate with their neurologists, 477 (46.9%) reported compliance to treatment, and 597 (58.7%) reported overuse of analgesics. | 2020-09-25 |
| 32972381 | The treatment of these patients poses unique and significant challenges to health care providers requiring changes in existing protocols. […] A change in stroke workflow and protocols is now necessary in order to deliver the appropriate life-saving therapy for COVID-19 positive patients while protecting medical providers. | 2020-09-25 |
| 32972430 | We have conducted this systematic review and meta-analysis on efficacy and safety of the drug FVP as a treatment for COVID-19. […] The studies with the standard of care (SOC) and FVP as a treatment drug were considered as the treatment group and the SOC with other antivirals and supportive care as the control group. […] There are 31 randomized controlled trials (RCTs) registered in different parts of the world focusing FVP for COVID-19 treatment. […] There is a significant clinical and radiological improvement following treatment with FVP in comparison to the standard of care with no significant differences on viral clearance, oxygen support requirement and side effect profiles. | 2020-09-25 |
| 32972435 | A statement of consensus was formulated after reviewing available literature on pediatric treatment strategies for COVID-19 by the Steering and Scientific Committee of the Italian Society of Infectious Pediatric Diseases in connection with the Italian Society of Paediatrics. | 2020-09-25 |
| 32972561 | To manage these arrhythmias, it is imperative to increase the awareness of potential drug-drug interactions, to monitor QTc prolongation while receiving COVID therapy and provide special considerations for patients with inherited arrhythmia syndromes. | 2020-09-25 |
| 32972631 | Randomized controlled trials testing vitamin D supplementation in the treatment of COVID-19 are in progress. […] Positive results in such studies would encourage the use of vitamin D supplements as an adjuvant treatment in COVID-19. | 2020-09-25 |
| 32972763 | Patient quickly died before any COVID-19’s treatment. | 2020-09-25 |
| 32972795 | Early identification of these high morbidity conditions is key to allow for optimal treatment and improved outcomes. | 2020-09-25 |
| 32972804 | The aim of this multicentre retrospective study of rheumatic patients in the Italian regions of Lombardy and Marche was to determine whether patients receiving biological or small molecules treatment are more susceptible to the development of COVID-19 than the general population. | 2020-09-25 |
| 32972853 | Patients requiring surgical consultation and treatment for de-novo surgical disease had longer median ICU-LOS (31.5 vs 12 days, p = 0.0004). | 2020-09-25 |
| 32972861 | COVID-19 convalescent plasma (CCP) (i.e. plasma collected from individuals after their recovery from COVID-19) has emerged as a leading medical treatment for COVID-19. […] CCP is a therapy that could be implemented in LMICs. | 2020-09-25 |
| 32972994 | Our results pave the way to implement antibody cocktails for prophylaxis or therapy, circumventing or limiting the emergence of viral escape mutants. | 2020-09-25 |
| 32973125 | CASE REPORT This is a report of 2 nosocomial COVID-19 infections and severe COVID-19 pneumonia in 2 patients who were hospitalized during treatment for alcoholic liver disease (ALD). | 2020-09-25 |
| 32973373 | In France, priority was given to hospital reorganization, especially intensive care units. | 2020-09-25 |
| 32973504 | One potential therapy that has garnered international attention is hydroxychloroquine; a potent immunomodulatory agent FDA-approved for the treatment of numerous inflammatory and autoimmune conditions, including malaria, lupus, and rheumatoid arthritis. […] Hydroxychloroquine has demonstrated promise in vitro and is currently under investigation in clinical trials for the treatment of COVID-19. […] Results from this report introduce additional FDA-approved drugs that warrant investigation for therapeutic use in the treatment of COVID-19. | 2020-09-25 |
| 32973505 | The vital drug candidates, which are being tested as potential vaccines or therapeutics against COVID-19, include live attenuated vaccine, inactivated or killed vaccine, subunit vaccine, antibodies, interferon treatment, repurposing existing drugs, and nucleic acid-based vaccines. | 2020-09-25 |
| 32973511 | This study was designed to evaluate the efficacy of remote medication management of rivaroxaban by pharmacists for geriatric patients with nonvalvular atrial fibrillation during the COVID-19 pandemic. […] A single-site, prospective cohort study was conducted among patients with non-valvular atrial fibrillation who received rivaroxaban therapy from July 2019 to December 2019. […] The number and type of provider encounters, interventions related to rivaroxaban therapy, the occurrence of thromboembolism or bleeding, and the time of the first outpatient visit after discharge were recorded. […] Remote pharmacist-led medication instruction of rivaroxaban could reduce bleeding complications of the gastrointestinal tract and skin ecchymosis and postpone the first outpatient revisit after discharge. | 2020-09-25 |
| 32973526 | To date no specific antiviral drug have been approved for COVID-19, so the treatment of the disease is mainly focused on symptomatic treatment and supportive care. | 2020-09-25 |
| 32973527 | Up to now, effective antiviral treatment against COVID-19 is not available. […] As a pioneering strategy, prompt accumulation and long-term maintenance of these memory NK cells could be an efficacious viral treatment. […] Another aspect of NK cells we should note, utilizing modified NK cells such as allogeneic off-the-shelf CAR-NK cells as a state-of-the-art strategy for the treatment of COVID-19. […] In this contribution, we will briefly discuss the current status and future perspective of NK cells, which provide to successfully exploit NK cell-mediated antiviral activity that may offer important new tools in COVID-19 treatment. | 2020-09-25 |
| 32973534 | Additionally, we discuss the potential treatments for COVID-19, aiming at a better understanding of the pathogenesis of SARS-CoV-2 and providing new ideas for the personalized treatment of COVID-19. | 2020-09-25 |
| 32973535 | We included 82 randomized controlled trial (RCT) protocols investigating treatment modalities for COVID-19. | 2020-09-25 |
| 32973537 | We propose that lithium carbonate may deserve a place in the treatment against COVID-19. | 2020-09-25 |
| 32973575 | Based on GLM, a significant other’s COVID-19 illness, being on psychiatric medication, employment of safety and checking behaviors, and compliance with guidelines were associated with higher COVID-19-related fear. | 2020-09-25 |
| 32973638 | This 2-arm intent-to-treat non-inferiority study reports on a clinical trial on VCP and documents how therapeutic working alliance and motivation toward psychotherapy are associated to treatment outcome. […] We hypothesized that VCP would not be inferior to standard face-to-face (FF) cognitive behavior therapy for PDA. […] No specific hypothesis was stated to address working alliance and treatment mechanisms. […] VCP was compared to a gold-standard psychotherapy treatment for PDA, which was delivered either in person or in videoconference, with a strict tolerance criterion of about 2 points on the primary outcome measure. […] Motivation toward therapy at pre-treatment and working alliance after the fifth therapy session were used as predictors of treatment outcome and compared with change in dysfunctional beliefs toward bodily sensations. […] Panic disorder, agoraphobia, fear of sensations and depressed mood all showed significant improvements and large effect-sizes from pre to post-treatment. […] Non-inferiority tests confirmed that VCP was no less effective than FF therapy on the primary outcome measure and two of the three secondary outcome measures. […] Working alliance and motivation did not predict treatment outcome, which was significantly predicted by the reduction in dysfunctional beliefs. | 2020-09-25 |
| 32973803 | Nearly all nations were unprepared for this pandemic with healthcare systems stretched to their limits due to the lack of an effective vaccine and treatment. […] This review provides insight into key innate immune mechanisms that will aid in the development of therapeutics and preventive vaccines for SARS-CoV-2 infection. | 2020-09-25 |
| 32973814 | Importantly, treatment with metformin alleviates various lung injuries in preclinical animal models. […] Furthermore, retrospective clinical studies have revealed that metformin treatment reduces the mortality of T2D with COVID-19. | 2020-09-25 |
| 32973818 | There is no known successful treatment as of this time, and there is a need for medical options to mitigate this current epidemic. | 2020-09-25 |
| 32973919 | At present, diagnosis and treatment are of great concern. […] By summarizing the follow-up study on mental and psychological health of SARS in the past 10 years, and combining the characteristics of the existing cases of COVID-19, we will provide suggestions for the prevention and treatment of psychological diseases in clinical practice. | 2020-09-25 |
| 32973965 | Major advancements in the hyperacute diagnosis and treatment of stroke have justified our call-to-action slogan of “Time is Brain”-faster therapy leads to superior outcomes. | 2020-09-25 |
| 32974109 | Specific clinical characteristics, laboratory findings, treatments and clinical outcomes were analyzed from patients hospitalized for treatment from 1 February to 15 March 2020, and subsequently died or were discharged. | 2020-09-25 |
| 32974210 | Six patients (33%) were on active anti-tumor treatment: 2 (33%) received anti-tumor therapy within 2 weeks before the infection diagnosis and 2 (33%) continued oncological treatment after SARS-CoV-2 positivity. | 2020-09-25 |
| 32974227 | Such high-risk groups should be identified, stratified and actively monitored during treatment to prevent the development or progression of complications such as cardiac injury and ARDS. | 2020-09-25 |
| 32974230 | Under the prevailing situation of seeking better prevention, treatment and vaccination for COVID-19, in-depth research in the above portrayed metrics would be an added knowledge for the researchers. | 2020-09-25 |
| 32974243 | He responded well to standard-dose prednisone treatment for nephrotic syndrome. […] At 1 week after starting the prednisone treatment, he went into clinical remission. […] The patient responded well to the standard-dose prednisone treatment that is typically used for new-onset nephrotic syndrome. […] We offer insight on the success of standard treatment of nephrotic syndrome with COVID-19. | 2020-09-25 |
| 32974268 | Related scientific papers have rapidly extended information regarding the diagnosis, treatment and epidemiology of COVID-19 infection. […] To date, no vaccine or definitive treatment is available to defeat the virus and therapies are mainly based on existing drugs used to treat other conditions. […] Here, we have reviewed 526 ongoing clinical trials for COVID-19 to provide a perspective on the first 6 months of global efforts to identify an effective therapy. | 2020-09-25 |
| 32974374 | Whilst many reports have characterized the clinical, epidemiological, laboratory, and radiological features, as well as treatment and clinical outcomes of patients with COVID-19 pneumonia, information on SARS-CoV-2 reactivation remains unreported. […] Curative and eradicative therapy for COVID-19 is not currently available (3). | 2020-09-25 |
| 32974417 | Teleconsultation may be used to advise patients for therapy and symptom control measures, as well as to advise new patients regarding diagnostic tests. […] Surgical decision making may be stratified into three categories: patients with low (not life threatening) or intermediate (potential for future morbidity or mortality) acuity may be delayed; those with high acuity may be taken up for planned therapy after explaining the risks. | 2020-09-25 |
| 32974420 | In total, 44.4% of patients on treatment had associated comorbidities that imposed an additional risk. […] One hundred twenty-three patients continued treatment with their initial plan of radiotherapy or chemotherapy. […] Patients were monitored for the development of treatment-related toxicities and COVID-19-related symptoms. […] Thus, it is essential to cautiously select patients for treatment, minimizing the risk of exposure but adequately addressing the underlying disease. | 2020-09-25 |
| 32974857 | In the absence of specific vaccines and antiviral drugs, the China National Health Commission has released a series of COVID-19 treatment guidelines, which include symptomatic treatment, antiviral treatment, and traditional Chinese medicines (TCM). […] Aim of the review To analyze and summarize the role of TCMs in the treatment of COVID-19. […] Studies on TCMs have demonstrated that these compounds possess broad-spectrum antiviral and antibacterial properties, and they have certain advantages in the treatment of viral pneumonia and other emergent infectious diseases. […] Treatment based on syndrome differentiation is one of the significant features in TCM. […] These properties allow TCMs to be used in the treatment of COVID-19. […] Conclusion TCMs have been widely used in the treatment of COVID-19 in China. | 2020-09-25 |
| 32975134 | IHCAs during the COVID-19 pandemic occurred more often on general medicine wards than in intensive care units (46% vs 33%; 19% vs 60% in 2019, p<0.001), were overall shorter in duration (median time of 11 min (8.5-26.5) vs 15 min (7.0-20.0), p=0.001), led to fewer endotracheal intubations (52% vs 85%, p<0.001) and had overall worse survival rates (3% vs 13%, p=0.007) compared to IHCAs prior to the COVID-19 pandemic. | 2020-09-25 |
| 32975412 | The results showed that it is dangerous to use a contaminated FFR without any microbe inactivation treatment because the bacteria can live for more than 8 h. […] Ultraviolet irradiation (UVI) effectively inactivated the surface bacteria with a short treatment of 5 min and did not affect the filtration performance. | 2020-09-25 |
| 32975484 | We find that fluoxetine, a widely used antidepressant and a functional inhibitor of acid sphingomyelinase (FIASMA), efficiently inhibited the entry and propagation of SARS-CoV-2 in the cell culture model without cytotoxic effects and also exerted potent antiviral activity against two currently circulating influenza A virus subtypes, an effect which was also observed upon treatment with the FIASMAs amiodarone and imipramine. […] As the FIASMA group consists of a large number of small compounds that are well-tolerated and widely used for a broad range of clinical applications, exploring these licensed pharmaceuticals may offer a variety of promising antivirals for host-directed therapy to counteract enveloped viruses, including SARS-CoV-2. | 2020-09-25 |
| 32975564 | Survival will also need to be weighed against burden of treatment, as well as longer-term functional deficits and quality-of-life. […] By identifying the robust older people who may benefit from critical care, clinicians should proceed to elicit his values and preferences that would determine the treatment most aligned with his best interest. | 2020-09-25 |
| 32975814 | Adverse outcomes defined as intensive care units, oxygen saturation less than 90%, invasive mechanical ventilation, severe disease, and in-hospital mortality. | 2020-09-25 |
| 32975842 | Overall, five patients were included: all were virologically-suppressed on antiretroviral therapy and CD4+ count was greater than 350 cell/mm3 in all but two patients. | 2020-09-25 |
| 32976038 | None of our children with JIA-associated uveitis was advised to stop the ongoing immunosuppressant systemic therapy. | 2020-09-25 |
| 32976055 | Systemic treatment with steroids normalized her inflammatory and coagulation status and the occlusion completely resolved. | 2020-09-25 |
| 32976118 | While corticosteroids dampen the dysregulated immune system and sometimes are prescribed as an adjunctive treatment for pneumonia, their effectiveness in the treatment of coronavirus 2019 (COVID-19) remains controversial. […] In this issue of the JCI, Liu and Zhang et al. evaluated corticosteroid treatment in more than 400 patients with severe COVID-19. […] We posit that treatment timing, dosage, and COVID-19 disease severity determine immune response and viral outcome. […] Patients with moderate-to-severe COVID-19 pneumonia are likely to benefit from moderate dose corticosteroid treatment when administered relatively late in the disease course. | 2020-09-25 |
| 32976364 | Specific data on presentation, clinical course, treatment and prognosis was acquired. | 2020-09-25 |
| 32976940 | The nature of calls changed to COVID-19-related topics, including confirmation of forms on the registry, urgent desire to initiate advance care planning, temporary rescindment of treatment-limiting forms, and questions on how to honor patients’ wishes in advance directives and medical orders in light of their COVID-19 status. | 2020-09-25 |
| 32976945 | Therapeutic presence is one of the fundamental skills that palliative care providers have to offer. […] This narrative piece about a remote cross-country palliative care encounter offers reflections on creating therapeutic presence amidst the current pandemic. | 2020-09-25 |
| 32977050 | Subjects who were living in psychiatric residential treatment facilities, had cannabis addiction and a diagnosis of obsessive-compulsive disorder were significantly more likely to present to emergency psychiatric consultations during lockdown. | 2020-09-25 |
| 32977128 | Early diagnosis and treatment of VTE is warranted. | 2020-09-25 |
| 32977525 | The problem of treating viral infections is extremely relevant due to both the emergence of new viral diseases and to the low effectiveness of existing approaches to the treatment of known viral infections. | 2020-09-26 |
| 32977547 | It exhibits significant antibacterial activities against a broad range of pathogens, and was observed by scanning electron microscopy (SEM) to cause cellular lysis through pore formation in bacterial membranes, implying that its antibacterial activity may be mediated by peptides or proteins and supported by proteinase K treatment. | 2020-09-26 |
| 32977764 | Data on the clinical picture of transplant recipients and management of the anti-rejection immunosuppressive therapy on COVID-19 infection are lacking. […] Both patients received a combination therapy including antiviral treatment and reduced immunosuppression therapy and finally recovered. | 2020-09-26 |
| 32977781 | The majority of participants considered the platform of virtual reality training realistic for the initial clinical assessment (77%), diagnostic activity (94%), and treatment options (81%). | 2020-09-26 |
| 32977818 | History of medication for mental health problems was significantly associated with a higher likelihood of experiencing symptoms of anxiety (AOR: 3.40; 95% CI:1.31-8.81), depression (AOR: 3.83; 95% CI: 1.45-10.14) and insomnia (AOR: 3.82; 95% CI: 1.52-9.62) while inadequate precautionary measures in the workplace was significantly associated with higher odds of exhibiting symptoms of anxiety (AOR: 1.89; 95% CI: 1.12-3.19) and depression (AOR: 1.97; 95% CI: 1.16-3.37). […] Health workers facing stigma, those with history of medication for mental health problems, and those reporting inadequate precautionary measures in their workplace were more at risk of developing mental health outcomes. | 2020-09-26 |
| 32977949 | Andrographolide is a highly abundant natural product of the medicinal plant, Andrographis paniculata, which has been clinically used for inflammatory diseases and anti-viral therapy. […] Considering that andrographolide is used in clinical practice with acceptable safety and its diverse pharmacological activities that could be beneficial for attenuating COVID-19 symptoms, extensive investigation of andrographolide on the suppression of 2019-nCoV as well as its application in COVID-19 therapy is suggested. | 2020-09-26 |
| 32977993 | Almost half of the departments cancelled face-to-face medical consultations (40%) and 48% of the treatment rooms were turned into COVID beds. […] Most of the rehabilitation departments developed both graphic and audiovisual material with exercises, referral protocols and guidelines for the rehabilitation management and treatment of COVID 19 patients. | 2020-09-26 |
| 32978093 | The aim of this study was to evaluate the impact of redeployment of surgical trainees to intensive care units (ICUs) during the COVID-19 pandemic-in terms of transferrable technical and nontechnical skills and wellbeing. | 2020-09-26 |
| 32978255 | The present finding may open up for new treatment options in severe Covid-19, aiming at reducing the presence and production of hyaluronan in the lungs. | 2020-09-26 |
| 32978304 | This paper critically reviews two such criteria and evaluates whether the use of effective treatment should be a necessary condition for the ethical acceptability of SARS-CoV-2 CHIs, and whether the choice of study sites should be influenced by COVID-19 incidence levels. | 2020-09-26 |
| 32978309 | However, the effects of asthma, asthma medication, and asthma severity on the clinical outcomes of COVID-19 have not yet been established. […] Asthma and asthma severity (step suggested by GINA) was defined using the diagnostic code and history of asthma medication usage. […] Asthma medication use and asthma severity also did not affect the clinical outcomes of COVID-19. […] Asthma led to poor outcomes of COVID-19; however, underlying asthma, use of asthma medication, and asthma severity were not independent factors for poor clinical outcomes of COVID-19, generally. | 2020-09-26 |
| 32978313 | Food and Drug Administration (FDA)-approved vaccines or therapeutics available for the prevention or treatment of SARS-CoV-2 infection and/or associated COVID-19 disease, which has triggered a large influx of scientific efforts to develop countermeasures to control SARS-CoV-2 spread. […] This SARS-CoV-2 BAC-based reverse genetics will facilitate studies addressing several important questions in the biology of SARS-CoV-2, as well as the identification of antivirals and development of vaccines for the treatment of SARS-CoV-2 infection and associated COVID-19 disease.IMPORTANCE The pandemic coronavirus (CoV) disease 2019 (COVID-19) caused by severe acute respiratory syndrome CoV-2 (SARS-CoV-2) is a major threat to global human health. […] To date, there are no approved prophylactics or therapeutics available for COVID-19. […] The BAC-based reverse genetics approach will facilitate the study of SARS-CoV-2 and the development of prophylactics and therapeutics for the treatment of COVID-19. | 2020-09-26 |
| 32978337 | Moderate and severe cases require hospitalisation as well as intensive therapy which includes non-invasive as well as invasive ventilation, along with antipyretics, antivirals, antibiotics and steroids. […] Complicated cases may require treatment by immunomodulatory drugs and plasma exchange therapy. | 2020-09-26 |
| 32978339 | The combined effects of COVID-19, containment measures and fragmentation of tuberculosis services have resulted in delays in diagnosis or non-diagnosis and disruption in treatment resulting in increased morbidity, mortality, transmission and drug resistance. | 2020-09-26 |
| 32978340 | COVID-19 had also disrupted testing and treatment for sexually transmitted infections and HIV services for sex workers. | 2020-09-26 |
| 32978341 | Since access to antiretroviral therapy (ART) was immediately disrupted, Ashodaya adapted its HIV outreach programme to form an alternative, community-led system of distributing ART at discreet, private sites. | 2020-09-26 |
| 32978364 | Case #2 was a 34-year-old woman whose treatment for SLE included 200 mg of hydroxychloroquine per day since 2017. | 2020-09-26 |
| 32978702 | Our objective was to evaluate adverse drug reaction (ADR) reporting for drugs when used in the treatment of COVID-19 compared with use for other indications, specifically focussing on sex differences. […] In total, 2573 reports were identified for drugs used in the treatment of COVID-19. […] Review of a global database of suspected ADR reports revealed sex differences in the reporting patterns for drugs used in the treatment of COVID-19. | 2020-09-26 |
| 32978766 | This study was designed to explore the related changes in daily life and impacts on the well-being of a group of patients with chronic treatment-resistant depression (TRD) during the COVID-19 pandemic. | 2020-09-26 |
| 32978802 | Transfusion of SARS-CoV-2 convalescent plasma is a promising treatment for severe COVID-19 cases, with success of the intervention based on neutralizing antibody content. […] The ELISA-based correlation to neutralization titer enabled a threshold proposal that could be used to eliminate lower titer units from the clinical supply for COVID-19 treatment. | 2020-09-26 |
| 32978832 | Older adults affected with the SARS-CoV-2 virus present with distinct clinical manifestations necessitating specific treatment needs and management protocols. | 2020-09-26 |
| 32978860 | The coronavirus disease 2019 (COVID-19) pandemic challenges neurologists in counseling multiple sclerosis (MS) patients with respect to their risk for and by severe acute respiratory syndrome coronavirus 2 and in guiding disease-modifying treatment (DMT). […] For every risk group, the proportions of patients under DMT and immunosuppressive treatment were determined. […] Of the patients at high or very high risk, only one patient received DMT and none had an immunosuppressive therapy. | 2020-09-26 |
| 32978920 | Group therapy sessions were conducted in SDU where 50.59% patients participated. […] This study shows that it is safe and feasible to provide early physiotherapy treatment techniques in patients with COVID-19 using appropriate measures of infection prevention and cross contamination. | 2020-09-26 |
| 32978962 | Time is of the essence in evaluating potential drugs and biologics for the treatment and prevention of COVID-19. […] To demonstrate the potential value added by covariate adjustment in this context, we simulated two-arm, randomized trials comparing a hypothetical COVID-19 treatment versus standard of care, where the primary outcome is binary, ordinal, or time-to-event. […] From these simulations, we conclude that covariate adjustment is a low-risk, high-reward approach to streamlining COVID-19 treatment trials. | 2020-09-26 |
| 32979013 | Patient received standard prednisone and tacrolimus-based immunosuppression without induction therapy following transplant. | 2020-09-26 |
| 32979305 | Such services should prioritise the diagnosis and treatment of these patients to mitigate potential indirect harms to protect public health. | 2020-09-26 |
| 32979306 | We discuss symptomatology and treatment options. | 2020-09-26 |
| 32979360 | At present, there is no effective treatment or vaccine for COVID-19. […] Therefore, there is a crucial unmet need to develop a safe and effective treatment for COVID-19 patients. […] In the current review article, the potential mechanisms by which MSCs contribute to the treatment of COVID-19 patients are highlighted. | 2020-09-26 |
| 32979369 | The aim of this study was to investigate 28-day mortality after COVID-19 diagnosis in the European kidney replacement therapy population. […] In addition, we determined the role of patient characteristics, treatment factors, and country on mortality risk using ERA-EDTA Registry data on patients receiving kidney replacement therapy in Europe between February 1, 2020 and April 30, 2020. […] We identified differences in COVID-19 mortality across countries, and an increased mortality risk in older patients receiving kidney replacement therapy and male patients receiving dialysis. […] Thus, the pandemic has had a substantial effect on mortality in patients receiving kidney replacement therapy; a highly vulnerable population due to underlying chronic kidney disease and high prevalence of multimorbidity. | 2020-09-26 |
| 32979378 |
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2020-09-26 |
| 32979419 | At the end of the follow-up, treatment failure and death was significantly higher in patients with diabetes compared to those without diabetes (17.8% vs. | 2020-09-26 |
| 32979436 | The SARS-CoV-2 spike glycoproteins (SGPs) and human angiotensin converting enzyme 2 (ACE2) are the two key targets for the prevention and treatment of COVID-19. | 2020-09-26 |
| 32979474 | This implies an attempt to control cytokines, such as IFN-γ, with combined therapies for clinical treatment. | 2020-09-26 |
| 32979477 | The speed, at which novel SARS-CoV-2 mutants are selected and dispersed around the world, could pose problems for the development of vaccines and therapeutics. | 2020-09-26 |
| 32979557 | The VTE and no-VTE groups were compared by univariable analysis for demographics, comorbidities, laboratory data, and treatment outcomes. | 2020-09-26 |
| 32979572 | Tocilizumab has been proposed as a candidate therapy for patients with severe coronavirus disease 2019 (COVID-19), especially among those with higher systemic inflammation. | 2020-09-26 |
| 32979654 | Active guidance: to optimize infrastructure and strategies, to leverage novel therapeutics, enhance data collection, and improve inclusion of children in clinical trials. | 2020-09-26 |
| 32979663 | Many patients need care in hospital wards and intensive care units (ICU). […] The main treatment in these patients is surgery. | 2020-09-26 |
| 32979742 | Currently the treatment is principally symptomatic and prevention by proper use of personal protective equipment and other measures is crucial to limit the spread. | 2020-09-26 |
| 32979900 | Inhibition of each of these pathways may be a potential target in the treatment of COVID - 19. | 2020-09-27 |
| 32979936 | However, lockdowns and other extreme restrictions cannot be sustained for the long term in the hope that there will be an effective vaccine or treatment for COVID-19. | 2020-09-27 |
| 32979987 | For the COPD cohort, individuals were eligible if they were aged 35 years or older, had COPD, were a current or former smoker, and were prescribed an ICS or long-acting β agonist plus long-acting muscarinic antagonist (LABA-LAMA) as combination therapy within the 4 months before the index date. | 2020-09-27 |
| 32980151 | Evidence indicates that healthcare and social service providers (HSSPs) receive inadequate education related to recognizing and responding to child maltreatment. […] The objective of this commentary is to provide an overview of: (a) educational interventions for HSSPs’ related to recognizing and responding to child maltreatment; (b) the development of VEGA (Violence, Evidence, Guidance, Action), which is an online platform of educational resources to support HSSPs to recognize and respond to child maltreatment; and (c) the RISE (Researching the Impact of Service provider Education) project, which is an ongoing multi-province evaluation of VEGA in Canada. […] It is important to consider ongoing ways that HSSPs can receive education related to recognizing and responding to child maltreatment. […] The virtual implementation of VEGA and the RISE Project provide a necessary opportunity to continue to increase the capacity of Canada’s HSSPs to adequately and safely recognize and respond to child maltreatment, while simultaneously advancing education scholarship for the field of child maltreatment and which will have relevance for the COVID-19 context and beyond. | 2020-09-27 |
| 32980152 | This initial evidence from China may stress the importance of administering psychosocial intervention during the treatment of COVID-19 for better patient outcomes in other countries. | 2020-09-27 |
| 32980228 | Each received multiple (≥3) doses of nebulized racemic epinephrine with minimal to no improvement shortly after medication. […] All received dexamethasone early in their ED treatment and all were admitted. […] All three received at least one additional dose of dexamethasone, an atypical treatment occurrence in our hospital, due to each patient’s prolonged duration of symptoms. […] One child required heliox therapy and admission to intensive care. | 2020-09-27 |
| 32980345 | Here, in multiple, large cohorts of patients with inflammatory bowel disease (IBD), we have studied the intersections between Coronavirus Disease 2019 (COVID-19), intestinal inflammation and IBD treatment. […] These data generate a novel appreciation of the confluence of COVID-19- and IBD-associated inflammation and provide mechanistic insights supporting further investigation of specific IBD drugs in the treatment of COVID-19. | 2020-09-27 |
| 32980406 | There is no confirmed drug for the treatment of COVID-19 yet. […] As the disease spread fast and threaten human life, repositioning of FDA approved drugs may provide fast options for treatment. | 2020-09-27 |
| 32980424 | Ten were asymptomatic, 25 were treated as outpatients, 28 required admission without intensive care or ventilation, 13 required non-invasive ventilation or oxygen administration, 18 were admitted to intensive care units, 12 requiring invasive ventilation, and 3 extra corporeal membrane oxygenation. | 2020-09-27 |
| 32980434 | The aim of the study was to evaluate the role of chronic treatment with ACE-I or ARBs and other clinical predictors on in-hospital mortality in a cohort of COVID-19 patients. […] Timely treatment with low-molecular-weight heparin (LMWH) in ED was found to be protective (OR: 0.36; 95% CI: 0.21-0.62; p < 0.0001). | 2020-09-27 |
| 32980462 | Researchers and companies around the world are working on all the possible strategies to develop a curative or preventive strategy for the same, which includes vaccine development, drug repurposing, plasma therapy, and drug discovery based on Artificial intelligence. […] As an effort towards developing possible therapeutics for COVID-19, we have used machine-learning algorithms for the generation of alignment kernels from diverse viral sequences of Covid-19 reported from India, China, Italy and USA. | 2020-09-27 |
| 32980556 | Six patients with SCD had COVID-19 (1.6%): three remained asymptomatic, two had mild symptoms and one required oxygen therapy. | 2020-09-27 |
| 32980614 | The aims of the study were to review the rapidly emerging COVID-19 literature to determine 1) the relationship between obstructive sleep apnoea (OSA) and adverse COVID-19 outcomes and, 2) potential causal mechanisms 3) what effect COVID-19 has had on OSA diagnosis and 4) what effect COVID-19 has had on treatment and management of OSA during this period. […] It is clear that the pandemic has had a major effect on the treatment management and diagnosis of OSA and moving forward it may be necessary to explore new diagnosis and treatment pathways for these individuals. | 2020-09-27 |
| 32980626 | Till now many drugs have been considered in the treatment of COVID-19 pneumonia, but pharmacotherapy in elderly patients and patients with pre-existing comorbidities is highly challenging. […] In this review, different potential drugs which have been considered in COVID-19 treatment have been discussed in detail. | 2020-09-27 |
| 32980627 | A case series of cardiac ruptures during the COVID-19 lockdown and the surgical treatment of a huge post-ischemic cardiac pseudoaneurysm complicated by a “contained” free wall rupture are presented. | 2020-09-27 |
| 32980664 | The questionnaire survey focused on the impact of the COVID-19 pandemic on sleep, mental status, symptoms, and daily life and medical treatment of PD patients. […] Additional attention should be paid to the difficulty encountered by PD patients in seeking medical treatment. | 2020-09-27 |
| 32980714 | Digitized and Tailored Cognitive and Behavioral Therapy are proposed to address the psychiatric impact of COVID-19. | 2020-09-27 |
| 32980748 | This brief clinical review critically assesses the use of exposure and response prevention therapy (ERP) for patients with obsessive-compulsive disorder (OCD) in light of the COVID-19 pandemic. […] We discuss the ethical and practical considerations that clinicians employed in past infectious disease outbreaks, as well as general safety measures routinely practiced in the conduct of exposure therapy. | 2020-09-27 |
| 32980780 | Multiple sclerosis (MS) patients have been considered a higher-risk population for COVID-19 due to the high prevalence of disability and disease-modifying therapy use; however, there is little data identifying clinical characteristics of MS associated with worse COVID-19 outcomes. […] Disease-modifying therapy prevalence did not differ among courses (mild:17/19[89.5%], moderate:12/15[80%] and severe:3/6[50%], P = 0.123). […] However, disease-modifying therapy use was not different among courses. | 2020-09-27 |
| 32980805 | Virus severely endangers human life and health, and the detection of viruses is essential for the prevention and treatment of associated diseases. | 2020-09-27 |
| 32980852 | Surgical treatment was successful. | 2020-09-27 |
| 32980900 | The shelter hospital has multiple functions such as emergency treatment, surgical treatment and clinical test, which can adapt to emergency medical rescue tasks. […] Based on the characteristics that shelter hospital only treats patients with mild illness, tests of shelter laboratory, including coronavirus nucleic acid detection, IgM/IgG antibody serology detection, monitoring and auxiliary diagnosis and/or a required blood routine, urine routine, C-reactive protein, calcitonin original, biochemical indicators (liver enzymes, myocardial enzymes, renal function, etc.) and blood coagulation function test etc, were used to provide important basis for the diagnosis and treatment of the disease. | 2020-09-27 |
| 32981003 | The main goals were to evaluate patient compliance and to assess patient satisfaction. | 2020-09-27 |
| 32981399 | There is an urgent need for discovery methods for the prevention and treatment of COVID-19 infection. | 2020-09-28 |
| 32981461 | At present, no proper therapy and vaccinations are available for the disease, and it is increasing day by day with a high mortality rate. | 2020-09-28 |
| 32981694 | Oncologists must balance plausible risks of COVID-19 infection with the recognized consequences of delaying cancer treatment, keeping in mind the capacity of the health care system. […] We sought to investigate treatment patterns in gynecologic cancer care during the first two months of the COVID-19 pandemic at three affiliated New York City hospitals located in Brooklyn, Manhattan and Queens. […] Clinical and demographic data were abstracted from the electronic medical record with a focus on oncologic treatment. […] Multivariable logistic regression analysis was explored to evaluate the independent effect of hospital location, race, age, medical comorbidities, cancer status and COVID-19 status on treatment modifications. […] Among 302 patients with gynecologic cancer, 117 (38.7%) experienced a COVID-19-related treatment modification (delay, change or cancellation) during the first two months of the pandemic in New York. […] Sixty-four patients (67.4% of those scheduled for surgery) had a COVID-19-related modification in their surgical plan, 45 (21.5% of those scheduled for systemic treatment) a modification in systemic treatment and 12 (18.8% of those scheduled for radiation) a modification in radiation. […] On univariate analysis, hospital location in Queens or Brooklyn, age ≤65 years, treatment for a new cancer diagnosis versus recurrence and COVID-19 positivity were associated with treatment modifications. […] On multivariable logistic regression analysis, hospital location in Queens and COVID-19 positive testing were independently associated with treatment modifications. […] More than one third of patients with gynecologic cancer at three affiliated New York City hospitals experienced a treatment delay, change or cancellation during the first two months of the COVID-19 pandemic. […] Among the three New York City boroughs represented in this study, likelihood of gynecologic oncology treatment modifications correlated with the case burden of COVID-19. | 2020-09-28 |
| 32981754 | Previously, I suggested that arachidonic acid (AA, 20:4 n-6) and similar bioactive lipids (BALs) inactivate SARS-CoV-2 and thus, may be of benefit in the prevention and treatment of COVID-19. | 2020-09-28 |
| 32981908 | The Japanese Circulation Society proposes recommendations for all healthcare professionals involved in cardiovascular medicine to protect them from infection and ensure that seriously ill patients requiring urgent care receive proper treatment.Methods and Results:Patients are divided into “Positive or suspected coronavirus disease 2019 (COVID-19)” and “All others”. | 2020-09-28 |
| 32981926 | Apart from dual antiplatelet therapy, tocilizumab therapy was initiated due to the high interleukin-6 levels. | 2020-09-28 |
| 32981943 | The proposed review contains current information on the existing vaccine strains and the development of new, genetically engineered strains for the prevention of tuberculosis and the prevention and treatment of other diseases. | 2020-09-28 |
| 32981988 | All three outbreaks have commonly generated three distinct cohorts of studies: (i) studies linked to public health response and epidemic control, (ii) studies on chemical constitution of the virus; and (iii) studies related to treatment, vaccine and clinical care. | 2020-09-28 |
| 32982062 | No vaccine treatment has been defined against SARS-CoV2 or other human coronaviruses (HCoVs), including those causing epidemic infections, neither appropriate strategies for prevention and care are yet officially suggested. | 2020-09-28 |
| 32982184 | The results of these trials could constitute a reference for future clinical trials to be executed on COVID-19 treatment and prevention. | 2020-09-28 |
| 32982205 | Pulmonary rehabilitation (PR) is an important, evidence-based treatment that improves outcomes for people with COPD. | 2020-09-28 |
| 32982336 | Although some animal studies suggested that the use of ACEIs/ARBs could contribute for the prevention and treatment of the effects of the COVID-19 infection, there are also contradictory scenarios indicating that their use may exacerbate the deleterious conditions of the infection. | 2020-09-28 |
| 32982366 | Therefore, in this review article, we propose the mechanism of SARS-CoV-2-associated acute respiratory disease syndrome, and assess treatment options by considering IFNs and by targeting IFN-antagonist SARS-CoV-2 virulent gene products. | 2020-09-28 |
| 32982538 | COVID-19 is continuing as a big challenge for the globe and several types of research are continued to find safe and effective treatment and preventive options. […] Although there is a lack of conclusive evidence of their benefit, there is worldwide controversy to use anti-malarial drugs, hydroxychloroquine and chloroquine, for the treatment of COVID-19. […] FDA issued an emergency use authorization to the use of these drugs for the treatment of COVID-19. […] Against this fact, there are several rumors about the irresponsible use of these drugs in Africa for the treatment of COVID-19. […] This work aimed to review the off-label use of these drugs for the treatment of COVID-19 in African countries against WHO recommendation. […] Data on the use of these drugs for the treatment of COVID-19 in African countries were searched from credible sources including Scopus, PubMed, Hindawi, Google Scholar, and from local and international media. | 2020-09-28 |
| 32982600 | This review summarizes the current coronavirus disease 2019 (COVID-19) transmission pathways, high-risk factors, diagnostic points, pathogenesis, and therapeutic drugs to provide the prevention and treatment theories for COVID-19. […] For the treatment of COVID-19, the specific antiviral agents have not been developed, except for symptomatic supportive treatments. […] The methods for detecting SARS-CoV-2 infection have become increasingly mature, but specific antiviral drugs for the treatment of COVID-19 have not yet been developed. […] Treatment must pay attention to the cytokine storm that leads to the seriousness of COVID-19. | 2020-09-28 |
| 32982616 | However, scientific knowledge and therapeutic treatment options for this new coronavirus remain limited. […] Although previous outbreaks of human coronaviruses (CoVs) such as SARS and MERS stimulated research, there are, to date, no antiviral therapeutics available that specifically target these kinds of viruses. […] We therefore summarized and analyzed the latest progress in research to identify flavonoids for antiviral therapy and proposed strategies for future work on medicinal plants against coronaviruses such as SARS-CoV-2. | 2020-09-28 |
| 32982720 | The SARS-CoV-2 infection has triggered an impressive amount of clinical and experimental studies to identify an effective and safe therapy to stop the pandemic spread. […] The article revises the current state of SARS-CoV-2 therapeutic options but advises towards a more cautious and individualized treatment approach centred on the clinical features, immune particularities, and the risk-benefit balance. | 2020-09-28 |
| 32982751 | Interferon was the main prevention program, and antiviral drugs were the main treatment program. | 2020-09-28 |
| 32982881 | So too have its preventive and treatment measures. | 2020-09-28 |
| 32982888 | According to acceptance and commitment therapy (ACT), it involves behaving consistently with one’s chosen values even in the presence of emotional and mental discomfort. | 2020-09-28 |
| 32982925 | Early identification and aggressive treatment are particularly important for COVID-19 patients with neurological symptoms. | 2020-09-28 |
| 32982938 | There are several challenges facing endovascular therapy for stroke, including shortages of medical staff who may be deployed for COVID-19 coverage or who may have contracted the infection and are thus quarantined, patients avoiding early medical care, a lack of personal protective equipment, delays in door-to-puncture time, anesthesia challenges, and a lack of high-intensity intensive care unit and stroke ward beds. | 2020-09-28 |
| 32983056 | Testing for the presence of co-pathogens going forward will assist in the diagnosis and optimal treatment of suspected SARS-CoV-2 respiratory infections in the current pandemic. | 2020-09-28 |
| 32983123 | Canakinumab, a monoclonal antibody targeting IL-1β is under investigation for the treatment of severe SAR-CoV-2 infection. […] It may represent an useful treatment in severe cases. | 2020-09-28 |
| 32983161 | With only few case studies published on SARS-CoV-2 infection in patients with rheumatic diseases, we report a 25-year-old male who developed moderate coronavirus disease 2019 (COVID-19) with fever, mild dyspnea, and no major complications despite having received high-dose prednisolone, cyclophosphamide, and rituximab for the treatment of highly active, life-threatening eosinophilic granulomatosis with polyangiitis (EGPA). | 2020-09-28 |
| 32983179 | The rapid spread, severity, and lack of specific treatment for COVID-19 resulted in hasty drug repurposing. | 2020-09-28 |
| 32983254 | Because lung cancer patients have low immunity after anti-tumor treatment, they should become the main targets for epidemic prevention. […] It is necessary to provide individualized medical treatment and management for lung cancer patients based on patients’ conditions and regional epidemic patterns. | 2020-09-28 |
| 32983255 | Consolidating the knowledge that has accumulated during the first wave of this pandemic is essential for recognising the clinical signs, symptoms and effective treatment strategies for children; identifying children who may be at increased risk of severe SARS-CoV-2 infection; planning the safe delivery of healthcare and non-health related services that are important for childrens’ wellbeing; and engaging in, and developing, research to address the things that are not yet known. | 2020-09-28 |
| 32983259 | Chinese medicine Toujie Quwen granule (TJQW) has proven to be effective in the treatment of mild coronavirus disease 2019 (COVID-19) cases by relieving symptoms, slowing the progression of the disease, and boosting the recovery of patients. […] But the bioactive compounds and potential mechanisms of TJQW for COVID-19 prevention and treatment are unclear. […] Our findings suggested that TJQW treatment for COVID-19 was associated with elevation of immunity and suppression of inflammatory stress, including regulation of inflammatory response, viral process, neutrophil mediated immunity, PI3K-Akt signaling pathway, MAPK signaling pathway, Jak-STAT signaling pathway, Complement and coagulation cascades, and HIF-1 signaling pathway. […] Our study uncovered the pharmacological mechanism underlying TJQW treatment for COVID-19. […] These results should benefit efforts for people around the world to gain more knowledge about Chinese medicine TJQW in the treatment of this vicious epidemic COVID-19, and help to address this pressing problem currently facing the world. | 2020-09-28 |
| 32983308 | He was treated with empiric antibiotics, antiviral therapy, high-dose glucocorticoids, and interleukin antagonists. | 2020-09-28 |
| 32983409 | The benefits of proceeding with right heart catheterization, such as further characterization of hemodynamic subtype and severity of pulmonary hypertension, initiation of targeted pulmonary arterial hypertension therapy, as well as further hemodynamic testing, need to be carefully balanced with the risk of potentially exposing both patients and health care personnel to coronavirus disease 2019 infection. | 2020-09-28 |
| 32983456 | High-flow nasal cannula oxygen therapy (HFNC) has been shown to be a useful therapy in the treatment of patients with Acute Respiratory Distress Syndrome (ARDS), but its efficacy is still unknown in patients with COVID-19. […] Our objective is to describe its utility as therapy for the treatment of ARDS caused by SARS-CoV-2. […] The main outcome was the intubation rate at day 30, which defined failure of therapy. […] A ROX index less than 4.94 measured 2 to 6 h after the start of therapy was associated with increased risk of intubation (HR 4.03 [95% CI 1.18 - 13.7]; p=0.026). […] High-flow therapy is a useful treatment in ARDS in order to avoid intubation or as a bridge therapy, and no increased mortality was observed secondary to the delay in intubation. | 2020-09-28 |
| 32983694 | We sought to investigate this effect with analysis of our hospital’s stroke treatment protocols as well as stroke volume on state, regional, and national levels. | 2020-09-28 |
| 32983701 | The aim of this study was to evaluate the characteristics of clinical presentation, treatment, and outcome of COVID-19 infection among the HCP of our setting. | 2020-09-28 |
| 32983702 | The outcome measures analyzed were mortality rate, rate of disease progression/improvement, rate of disease severity, and adverse effects of treatment. | 2020-09-28 |
| 32983724 | Higher monitoring of patients with DM and COVID-19 is advised, as well as rapid and accurate diagnostic tests and treatment. | 2020-09-28 |
| 32983745 | Therefore, research for methods of treatment and prevention of COVID-19 positive pregnancies carries an importance. […] The aim of this study was to measure serum 25(OH)D, vitamin B12, and zinc levels in COVID-19 positive pregnant women to evaluate the role of these micronutrients in treatment and prevention. | 2020-09-28 |
| 32983830 | Currently, no cure or standard treatment for COVID-19 exists. | 2020-09-28 |
| 32983832 | Although liver transplantation has been performed for patients with ATTRv amyloidosis since 1990, late-onset patients were not eligible for this treatment. […] A strategy for monitoring patients that enables the choice of an appropriate treatment from comprehensive and long-term viewpoints should be established. | 2020-09-28 |
| 32983891 | He was initially treated with oral ciprofloxacin and after one week was transferred to our tertiary hospital, where antibiotic therapy was switched to meropenem and vancomycin due to the severity of the case and to the hospital’s microbiological profile. | 2020-09-28 |
| 32983909 | The disease is spreading through outbreaks despite the availability of modern sophisticated medical treatment. | 2020-09-28 |
| 32983928 | There is no specific antiviral treatment recommended at present for COVID-19. | 2020-09-28 |
| 32983936 | They were randomized to either the treatment with the bromhexine group or the control group, in a 1:1 ratio with 39 patients in each arm. […] Standard therapy was used in both groups and those patients in the treatment group received oral bromhexine 8 mg three times a day additionally. […] This affordable medication can easily be administered everywhere with a huge positive impact(s) on public health and the world economy. | 2020-09-28 |
| 32983949 | Adopting telemedicine services and the use of epilepsy helplines may be important in assisting epilepsy patients and ensuring that treatment continues uninterrupted. | 2020-09-28 |
| 32984017 | Here, we describe the case of a 72-year old male patient with B-cell depletion after maintenance treatment with rituximab for non-Hodgkin-lymphoma who had a prolonged COVID-19 course and initial false negative test results. […] Our case highlights the diagnostic pitfalls in diagnosing COVID-19 in B-cell depleted patients and discuss the role of B-cell depletion in the course and treatment of COVID-19. | 2020-09-28 |
| 32984046 | Patients with acute myeloid leukemia are at increased risk of complications from SARS-CoV-2 not only due to immune compromise related to the malignancy but also due to the acuity of the disease and intensity of treatment. | 2020-09-28 |
| 32984196 | In Italy, a biobank is “a non-profit organization that must be officially recognized by the appropriate healthcare authority in the member states and must guarantee the treatment, distribution and conservation of biological material according to standards of quality and professionalism,” but must not conserve material already regulated by specific laws, as is the case for organs for transplants, blood for transfusions, as well as embryos and gametes for medically assisted reproduction. | 2020-09-28 |
| 32984206 | There is limited consensus on treatment; but most children have been treated with immunoglobulins or steroids, and with early consideration of biologicals such anti-TNF and anti-IL1 agents. […] Treatment should ideally be within the context of controlled treatment trials. | 2020-09-28 |
| 32984256 | There were many interventions, but many trials did not provide specific drugs and their dosage and treatment duration. | 2020-09-28 |
| 32984363 | In summary, the implementation of preemptive measures after the first case appeared allowed us to be able to provide treatment to our patients. | 2020-09-28 |
| 32984404 | A 33-year-old female patient with a long history of ulcerative colitis, poorly controlled, was admitted with COVID-19 a few days after being discharged from the hospital for treatment of acute severe ulcerative colitis. […] Although steroid tapering and persistence of biologics are advised by professional groups, the best treatment strategy for IBD patients presenting a flare during the outbreak has yet to be defined. | 2020-09-28 |
| 32984405 | No specific treatment is yet available for severe acute respiratory syndrome coronavirus 2 (SARS-CoV 2), and a variety of antiviral, immune-modifying, and antioxidant agents are therefore under intense investigation. […] Echocardiography, including assessment of myocardial deformation, may provide a useful tool to monitor the effects of the various treatment regimens on cardiac function both acutely and in the midterm. | 2020-09-28 |
| 32984543 | This approach should dramatically accelerate our understanding and treatment of disease(s), enabling further discovery of pathophysiological mechanisms and leading to the identification of specific groups of patients that may benefit from personalized treatments. | 2020-09-28 |
| 32984561 | He had received treatment with convalescent plasma. […] He had received combination treatment with interferon beta 1b and lopinavir/ritonavir. […] Patient 1 responded partially to empirical, albeit delayed, therapy with intravenous immunoglobulins. […] Patient 2 recovered with no specific treatment. | 2020-09-28 |
| 32984564 | OCHOS (detected by the tilt test with transcranial Doppler monitoring) and SFN (confirmed by skin biopsy), and both OCHOS/SFN were attributed to Post Treatment Lyme Disease Syndrome of presumed autoimmune etiology. […] Patient recovered on symptomatic therapy. | 2020-09-28 |
| 32984620 | The coronavirus disease 2019 (COVID-19), the pandemic that originated in China has already spread into more than 190 countries, resulting in huge loss of human life and many more are at the stake of losing it; if not intervened with the best therapeutics to contain the disease. […] For that aspect, various scientific groups are continuously involved in the development of an effective line of treatment to control the novel coronavirus from spreading rapidly. […] Recent advancements in nucleic acid-based therapeutics are helpful in targeted drug delivery, safely and effectively. | 2020-09-28 |
| 32984743 | While treatment with intravenous hydrocortisone and levothyroxine were begun the patient developed a junctional escape rhythm. | 2020-09-28 |
| 32984765 | Until either efficacious therapy or vaccination for COVID-19 is achieved, there will be a need to regain world economic stability while yet controlling the pandemic with current approaches. | 2020-09-28 |
| 32984768 | Currently, the diagnosis and treatment of SARS-CoV-2 infection in patients with chronic kidney disease (CKD) are still unclear. […] We then discuss the emerging therapeutic approaches aimed at reducing kidney damage and protecting kidney function including virus removal, immunotherapy, supporting treatment, special blood purification therapy, etc. | 2020-09-28 |
| 32984784 | Patients were assigned in a 1:1 ratio to receive either aerosol inhalation treatment with IFN-κ and TFF2 every 24 h for six consecutive dosages in addition to standard care (experimental group) or standard care alone (control group). […] This study suggested that this combination treatment is able to facilitate clinical improvement (negative for virus, improvement by CT, reduced hospitalization stay) and thereby result in an early release from the hospital. | 2020-09-28 |
| 32984792 | In the big data era, artificial intelligence (AI) and network medicine offer cutting-edge application of information science to defining disease, medicine, therapeutics, and identifying targets with the least error. | 2020-09-28 |
| 32984799 | Anti-coagulant treatment diminished the thrombus, and the patient recovered and was discharged. | 2020-09-28 |
| 32984828 | For patients who received thrombolytic therapy, repeat thromboelastography demonstrated improvements in coagulation index and lysis at 30 minutes reflecting reduced hypercoagulability and increased fibrinolysis. | 2020-09-28 |
| 32984832 | Our model suggests that use of standard positive end-expiratory pressure/Fio2 tables, higher positive end-expiratory pressure strategies, and higher tidal volumes may all be potentially deleterious in type 1 coronavirus disease 2019 acute respiratory distress syndrome patients, and that a highly personalized approach to treatment is advisable. | 2020-09-28 |
| 32984833 | To determine whether placental cell therapy PLacental eXpanded (PLX)-PAD (Pluristem Therapeutics, Haifa, Israel) may be beneficial to treating critically ill patients suffering from acute respiratory distress syndrome due to coronavirus disease 2019. […] Mortality, time to discharge, and changes in blood and respiratory variables were monitored during hospitalization to day 17 posttreatment. […] Pao2/Fio2 improved in 5:8 patients after 24-hour posttreatment, with similar effects 48-hour posttreatment. […] Improvement in several variables such as C-reactive protein, positive end-expiratory pressure, and Pao2/Fio2 was observed following PLacental eXpanded (PLX)-PAD treatment, suggesting possible therapeutic effect. | 2020-09-28 |
| 32984837 | To describe three coronavirus disease 2019 patients suffering from acute respiratory distress syndrome under venovenous extracorporeal membrane oxygenation therapy and tight anticoagulation monitoring presenting a novel pattern of multifocal brain hemorrhage in various degrees in all cerebral and cerebellar lobes. […] We report on an unusual multifocal bleeding pattern in the white matter in three cases with severe acute respiratory distress syndrome due to coronavirus disease 2019 undergoing venovenous extracorporeal membrane oxygenation therapy. […] Frequency for this unusual brain hemorrhage in coronavirus disease 2019 patients with extracorporeal membrane oxygenation therapy at our hospital is currently 50%, whereas bleeding events in extracorporeal membrane oxygenation patients generally occur at 10-15%. | 2020-09-28 |
| 32984838 | The median (quartile 1-quartile 3) age was 65 years (54-76.59 yr), and there was evidence of differential respiratory treatment by decade of life (p = 0.0046); patients greater than 80 years old were generally not intubated. | 2020-09-28 |
| 32984847 | Hydroxychloroquine is one of several agents being evaluated in the treatment of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. […] We aimed to examine whether patients with rheumatological conditions receiving chronic hydroxychloroquine therapy are at less risk of developing SARS-CoV-2 infection than those not receiving hydroxychloroquine. | 2020-09-28 |
| 32985017 | In this review, regarding the effective herbal treatments on other coronavirus infections, promising natural products for COVID-19 treatment are suggested. | 2020-09-28 |
| 32985115 | Respondents demonstrated comparative optimism where they believed that as compared to others of the same age and gender, they were unlikely to experience a range of controllable (eg accidentally infect/ be infected) and uncontrollable (eg need hospitalization/ intensive care treatment if infected) COVID-19-related risks in the short term (P < .001). | 2020-09-28 |
| 32985211 | Development of effective therapy thus became an emergency. […] According to these reports, Resveratrol could be proposed as potential therapeutics in the treatment of SARS-CoV-2. | 2020-09-28 |
| 32985317 | This review outlines these ocular complications with a focus on preventative and treatment measures to avoid devastating visual outcomes for the patient. | 2020-09-28 |
| 32985322 | Among adults who reported delaying dental care due to the pandemic, 74.7% reported delaying a checkup, 12.4% reported delaying care to address something that was bothering them, and 10.5% reported delaying care to get planned treatment. | 2020-09-28 |
| 32985328 | During eight 24h-treatment-sessions blood flow (100-300 mL/min), dialysate flow (160-320 mL/min) and dialysate pH (7.6-9.0) were adapted to optimize arterial PaCO2 and pH. […] Interruptions of ADVOS-treatment repeatedly resulted in reversible deteriorations of paCO2 and pH. […] After 95 h of continuous extracorporeal decarboxylating therapy the patient had markedly improved circulatory parameters compared to baseline. | 2020-09-28 |
| 32985329 | Since the outbreak, the Hospital of Stomatology, Wuhan University, has provided emergency dental treatment, and none of their staff were infected while providing dental service, which indicates that comprehensive measures such as the use of advanced PPE and environmental disinfection can prevent cross-infection in dental practice. […] The analysis of the procedures followed during the emergency treatments indicated that OHCWs preferred to recommend conservative treatment to patients, suggesting that attention should be paid to the psychological impact of COVID-19 on dental practitioners. | 2020-09-28 |
| 32985333 | As COVID-19 cases began to rise in Ontario, Canada, in March 2020, increasing surge capacity in hospitals and intensive care units became a large focus of preparations. | 2020-09-28 |
| 32985379 | This study aims to compare a conventional medical treatment model with a telehealth platform for Maternal Fetal Medicine (MFM) outpatient care during the global novel coronavirus pandemic. […] In this study, we described the process of converting our MFM clinic from a conventional medical treatment model to a telemedicine platform. […] The rapid conversion of an MFM platform from convention medical treatment to telemedicine platform in response to the novel coronavirus pandemic resulted in protection of healthcare personnel and MFM patients, with only a modest decrease in clinical productivity during the initial roll-out. | 2020-09-28 |
| 32985513 | Despite the urgent need to find effective therapeutics, research on SARS-CoV-2 has been affected by a lack of suitable animal models. | 2020-09-28 |
| 32985653 | Repurposing drugs that have shown promise in inhibiting other viral infections could allow for more rapid dispensation of urgently needed therapeutics. […] The monocyclic UV-4 also prevented SARS-CoV-2-induced death and reduced viral replication after 24 hours of treatment, although the reduction in viral copies was lost after 48 hours. | 2020-09-28 |
| 32985717 | Although delaying definitive treatment of disorders presented a risk to specific individuals, countless others afforded life-saving resources necessary to overcome the most threatening manifestation of this illness. | 2020-09-28 |
| 32985747 | It will be vital to stay attuned to epidemiologists, public health officials, and infection control experts, because what they see today, the intensive care units will see tomorrow. | 2020-09-28 |
| 32985915 | Given their training in understanding wellness, distress, and psychotherapeutic treatment, mental health clinicians are well positioned to respond to this need. | 2020-09-28 |
| 32986137 | Therefore in this setting, due to the lack of anti-COVID treatment schedules, tailored management is mandatory to reduce the side effects, as consequence of impaired renal function and drugs interactions. […] We report the main treatment actually used against SARS-CoV-2, underlining its possible use in the nephropatic patients and the central role of nephrologists to improve the clinical outcome. | 2020-09-28 |
| 32986217 | The age of the patients, time of presentation, diagnoses, whereabouts of the patients, inpatient or outpatient, number and duration of the operative care and required capacity on the normal ward and intensive care units (ICU) were recorded. | 2020-09-28 |
| 32986226 | So far, there is limited clinical evidence on the effect of corticosteroid therapy for this disease. […] This study aims to investigate the association between corticosteroid therapy and the duration of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) clearance among patients with mild COVID-19. […] Baseline characteristics and durations of RNA clearance were compared between the corticosteroid and non-corticosteroid therapy groups. […] The independent effects of corticosteroid therapy on the duration of RNA clearance were estimated by generalized linear models. […] Among those patients, 36 patients (43.9%) received corticosteroid therapy. […] The adjusted multivariate models showed that the effects of corticosteroids were non-significant on the durations of onset to first RNA clearance [β 2.48, 95% CI (95% confidence interval) - 0.42 to 5.38, P = 0.0926] and to persistent RNA clearance (β 1.54, 95% CI - 1.41 to 4.48, P = 0.3016), and durations of therapy to first RNA clearance (β 2.16, 95% CI - 0.56 to 4.89, P = 0.1184) and to persistent RNA clearance (β 1.22, 95% CI - 1.52 to 3.95, P = 0.3787). […] Corticosteroid therapy in patients with mild COVID-19 was not associated with the duration of SARS-CoV-2 clearance, suggesting that the use of corticosteroids may not be beneficial for patients with mild COVID-19 and should be prudently recommended in clinical practice. | 2020-09-28 |
| 32986229 | Here, we performed comprehensive environmental contamination surveillance to evaluate the risk of viral transmission in AIIRs with 115 rooms in three buildings at the Shanghai Public Health Clinical Center, Shanghai, during the treatment of 334 patients infected with SARS-CoV-2. […] This study has provided information pertinent for infection control in AIIRs during the treatment of COVID-19 patients. | 2020-09-28 |
| 32986248 | This warrants aggressive health measures for early recognition of the problem and initiation of treatment to reverse injuries. | 2020-09-28 |
| 32986250 | Human leukocyte antigen (HLA)-based epitope prediction and its association with disease outcomes provide an important base for treatment design. | 2020-09-28 |
| 32986274 | A single treatment of low-dose (1.5-Gy) radiation to both lungs was delivered over the course of 10 to 15 minutes. […] There was no acute toxicity attributable to radiation therapy. […] Blood tests and repeat imaging confirm that low-dose whole-lung radiation treatment appears safe for COVID-19 pneumonia. | 2020-09-28 |
| 32986289 | Skin lesions resolved from less than 24 hours to up to 2 weeks following treatment with antihistamines and/or steroids. | 2020-09-28 |
| 32986475 | Clinical presentations, laboratory findings, imaging features, complications, treatment and outcomes were compared between patients with COVID-19 pneumonia and patients with CAP. | 2020-09-28 |
| 32986502 | Neurosurgeons were faced with the challenge of balancing treatment of patients with life-threatening conditions and preventing the cross-transmission of the virus. | 2020-09-28 |
| 32986516 | Missing at least one cycle of therapy by > 10% of patients was reported in 46.31% of the centers. | 2020-09-28 |
| 32986528 | We included 585 patients who were COVID-19 positive, of whom 117 had active malignancy, defined as those receiving cancer-directed therapy or under active surveillance within 6 months of admission. […] Nearly one half of patients with cancer were receiving therapy, and 45% of patients received cytotoxic or immunosuppressive treatment within 90 days of admission. […] This finding suggests that a diagnosis of active cancer alone and recent anticancer therapy do not predict worse COVID-19 outcomes and therefore, recommendations to limit cancer-directed therapy must be considered carefully in relation to cancer-specific outcomes and death. | 2020-09-28 |
| 32986664 | Considering the serious medical, economic and social consequences of this pandemic and the lack of definite medication and vaccine it is necessary to describe natural immune responses to the SARS-CoV-2 in order to exploit them for treating the patients and monitoring the general population. | 2020-09-28 |
| 32986793 | The inclusion criteria for enrollment of a case in COVIREGI-JP are both (1) a positive SARS-CoV-2 test and (2) inpatient treatment at a health care facility. | 2020-09-28 |
| 32986824 | Some sparse case reports have described various forms of encephalitis in COVID-19 disease, but very few data have focused on clinical presentations, clinical course, response to treatment and outcomes. […] Clinical presentation and laboratory markers, severity of COVID-19 disease, response to treatment and outcomes were recorded. twenty-five cases of encephalitis positive for SARS-CoV-2 infection were included. […] Patients with MRI alterations exhibited worse response to treatment and final outcomes compared to other encephalitis. […] SARS-CoV-2 infection is associated with a wide spectrum of encephalitis characterized by different clinical presentation, response to treatment and outcomes. | 2020-09-28 |
| 32986836 | For patients diagnosed with the novel coronavirus, COVID-19, evidence is needed to understand the effect of treatment by physical therapists in the acute hospital on patient outcomes. […] The primary aims of this study were to examine the relationship of physical therapy visit frequency and duration in the hospital with patients’ mobility status at discharge and probability of discharging home. […] Associations between these outcomes and physical therapy visit frequency or mean duration were tested using multiple linear or modified Poisson regression. […] For the 312 patients included, increased physical therapy visit frequency was associated with higher 6-Clicks mobility (b = 3.63; 95% CI = 1.54-5.71) and JH-HLM scores (b = 1.15; 95% CI = 0.37-1.93) at hospital discharge and with increased probability of discharging home (adjusted relative risk = 1.82; 95% CI = 1.25-2.63). […] Patients with COVID-19 demonstrated improved mobility at hospital discharge and higher probability of discharging home with increased frequency and longer mean duration of physical therapy visits. […] Physical therapy should be an integral component of care for patients hospitalized due to COVID-19. | 2020-09-28 |
| 32987038 | This prevents development of pharmacological treatments from various diseases in which NEP is implicated although recently a dual-acting drug sacubitril-valsartan (LCZ696) combining a NEP inhibitor and angiotensin receptor blocker has been approved for treatment of heart failure. | 2020-09-28 |
| 32987060 | In combination with recently published medical data of patients having SARS-CoV-2 infection and the latest studies, the manifestations of damage to cardiovascular system by COVID-19, possible pathogenic mechanisms and advances of the treatment are proposed in this article. | 2020-09-28 |
| 32987177 | A synthetic case population was derived probabilistically using distributions of age, sex, and underlying conditions from populations of West African countries to assess individual risk factors and treatment effect sizes. […] Logistic regression analysis was conducted to evaluate the adjusted odds of survival for patients receiving oxygen therapy or convalescent plasma, based on therapeutic effectiveness observed for other respiratory illnesses. […] After adjustment for sex, age, and underlying conditions in the synthetic case population, the odds of mortality for cases not receiving oxygen therapy was significantly higher than those receiving oxygen, such as due to disruptions to standard care (OR: 2.07; 95% CI: 1.56 - 2.75). […] Investment in sustainable production and maintenance of supplies for oxygen therapy, along with messaging around early and appropriate use for healthcare providers, caregivers, and patients could reduce COVID-19 deaths in SSA. […] The success of supportive or curative clinical interventions will depend on earlier treatment seeking, such that community engagement and risk communication will be critical components of the response. | 2020-09-28 |
| 32987182 | An antiviral treatment for SARS-COV2 was administered, in addition to HIV treatment, in 5/30 patients (16,3%). | 2020-09-28 |
| 32987381 | However, reports are lacking concerning the treatment and prognosis of COVID-19 pneumonia in renal transplant recipients with acute cardiorenal syndrome. […] In the early phase of SARS-Cov-2 infection, the patient exhibited extensive lung lesions and significant acute kidney and heart injuries, which required treatment in the ICU. […] After correcting the arrhythmia and heart failure, the patient recovered quickly from the acute kidney injury with a treatment of intensive diuresis and strict control of fluid intake. […] This effectively treated case may be meaningful and referable for the treatment of COVID-19 pneumonia in other transplant recipients with acute cardiorenal syndrome. | 2020-09-28 |
| 32987502 | Moreover, the drug effects on virus growth and immunity effect of patients are also implemented to analyze the model. | 2020-09-29 |
| 32987701 | Furthermore, the involvement of mitochondrial ROS in the signaling of new prescribed drugs and in other pathologies (or in other unmet medical needs, such as gender differences or coronavirus disease of 2019 (COVID-19) treatment) is still being revealed; guaranteeing that research on mGSH will be an interesting topic for years to come. | 2020-09-29 |
| 32987712 | It has been found that the time spent learning about COVID-19 and the level of knowledge about symptoms, pathways, prevention, treatment, or prognosis are associated with the level of distress, where 25% of participants were found to have spent more than 3 h daily on this activity. | 2020-09-29 |
| 32987757 | There is a vast practice of using antimalarial drugs, RAS inhibitors, serine protease inhibitors, inhibitors of the RNA-dependent RNA polymerase of the virus and immunosuppressants for the treatment of the severe form of COVID-19, which often occurs in patients with chronic diseases and older persons. | 2020-09-29 |
| 32987828 | With the global threat of SARS-CoV-2, much effort has been focused on treatment and disease control. […] With the treatment of antiviral remdesivir, the selected BCoV variant with an altered genome structure developed resistance, but its pathogenicity was not increased in comparison to that of wild type (wt) BCoV. | 2020-09-29 |
| 32988321 | This column reviews results of past research to examine how a recession might affect behavioral health and the treatment of mental and substance use disorders and suggests potential policy solutions. […] Despite increases in suicide and substance use, losses in employment-related health insurance could dampen treatment seeking. […] Federal support for community behavioral health organizations should continue to offset state and local budget cuts and ensure provision of needed treatment. | 2020-09-29 |
| 32988645 | Eight Intensive Care Units (ICU) from 6 hospitals of Canary Islands (Spain). | 2020-09-29 |
| 32988730 | Herein, we report good outcomes in two patients with COVID-19 who received systemic corticosteroids as adjunctive therapy. […] These results suggest that some patients with COVID-19 may benefit from the appropriate use of systemic corticosteroids as adjunctive therapy. | 2020-09-29 |
| 32988758 | In this literature review, we summarize the most recent studies, which covered the pathophysiology of COVID-19 induced liver injury including; hepatic pathological findings, therapy related liver damage, and the effects of the viral infection on pre-existing liver diseasesin context of the most recent recommendations. | 2020-09-29 |
| 32988772 | In view of devastating effects of COVID-19 on human life, there is an urgent need for the licened vaccines or therapeutics for the SARS-CoV-2 infection. […] Age-old passive immunization with protective antibodies to neutralize the virus is one of the strategies for emergency prophylaxis and therapy for coronavirus disease 2019 (COVID-19). […] In this review, the authors discuss up-to-date advances in immune-based therapy for COVID-19. […] The use of convalescent plasma therapy as the first line of defense to treat severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has been established, with encouraging results. […] Considering the counterproductive antibody-dependent enhancement of the virus, mAbs therapy that is safe and efficacious, even in people with underlying conditions, will be a significant breakthrough. | 2020-09-29 |
| 32989379 | Automatic diagnosis of COVID-19 from medical imaging enables precise medication, helps to control community outbreak, and reinforces coronavirus testing methods in place. | 2020-09-29 |
| 32989407 | Long-term pneumonia morbidity, steroid therapy, positive pressure ventilation, and extracorporeal membrane oxygenation can cause pneumothorax, leading to capillary and alveolar damage. | 2020-09-29 |
| 32989410 | Combining mechanistic models and machine learning algorithms has led to improvements in the treatment of Shigella and tuberculosis through the development of novel compounds. […] Similarly, in-host and host-host models have supported the development of new HIV treatment modalities and an improved understanding of the immune involvement in influenza. | 2020-09-29 |
| 32989413 | Molecular epidemiological studies have discovered the mutability of SARS-CoV-2 which is of utmost importance for the development of therapeutics and vaccines for COVID-19. […] The whole world is now participating in the race for development of better and rapid diagnostics and therapeutics for COVID-19. | 2020-09-29 |
| 32989417 | Suspicious accidental COVID-19 findings in Nuclear Medicine Department need to be reported and appropriately evaluated to implement proper supportive treatment and infection control measures. | 2020-09-29 |
| 32989425 | We aim to describe the management of this condition as well as the outcomes in relation to the therapy chosen, in order to gain insight into improving patient care in the coming months. | 2020-09-29 |
| 32989427 | She was treated with hydroxychloroquine, azithromycin, and doxycycline at an outside facility and finished the treatment 5 days prior to admission to our facility. | 2020-09-29 |
| 32989430 | We aimed to explore the treatment changes and delays of early breast cancer (EBC) during the first quarter of 2020. […] EBC patients who received treatment regardless of preoperative therapy, surgery or postoperative therapy during first quarter of 2020 were included. 8397 patients were eligible with a median age of 50 (IQR 43-56). 0·2% (15/8397) of EBC patients were confirmed as COVID-19 infection. […] Only 5·2% of breast cancer diagnosis occurred after quarantine in Hubei compared with 15·3% in other provinces (OR= 0·30, 95%CI 0·24-0·38). postoperative endocrine therapy were least affected compared with different regions after quarantine (OR=0·37 [95%CI 0·19-0·73]). […] Compared with intervals from diagnosis to treatment before quarantine restrictions, the average time increased with significance from 3·5 to 7·7 days in Hubei and 5·7 to 7·7 days in other provinces (p< 0·001). […] There were also 18·5 and 7·2 days delay in Hubei and other provinces respectively when calculating interval from surgery to postoperative therapy. […] After implementation of COVID-19 quarantine restrictions, fewer diagnosis and surgery with significant delays were seen when compared with treatment before. | 2020-09-29 |
| 32989433 | Patients from Europe experienced the most treatment delays (P = .0031). | 2020-09-29 |
| 32989438 | This demonstrated complete resolution at 11 weeks with warfarin therapy. | 2020-09-29 |
| 32989525 | These findings may prove to be useful in the correct staging of disease, and this could have implications for treatment and patient follow-up. | 2020-09-29 |
| 32989642 | Heat treatment of clinical specimens from COVID-19 patients at 56°C for 30 min or 65°C for 15 min could be a useful method for the inactivation of a highly contagious agent, SARS-CoV-2. | 2020-09-29 |
| 32989666 | Epidemiological description and case reports will be key to a better recognition and to adequate treatment of pediatric patients with COVID-19. | 2020-09-29 |
| 32989677 | Our observations encourage future research to understand the underlying molecular mechanisms and to improve treatment outcome of COVID-19. | 2020-09-29 |
| 32989778 | Therefore, the Arkansas Initiative for Convalescent Plasma was developed to ensure that every Arkansan has access to this therapy. | 2020-09-29 |
| 32989856 | Convalescent plasma, a method of passive immunization that has been applied to prior viral pandemics, holds promise as a potential treatment for COVID-19. […] Immunocompromised patients may experience more benefit from convalescent plasma given underlying deficits in B and T cell immunity as well as contraindications to antiviral and immunomodulatory therapy. […] This preliminary evidence suggest that convalescent plasma may be safe among immunosuppressed patients with COVID-19, and emphasizes the need for further data on efficacy of convalescent plasma as either primary or adjunctive therapy for COVID-19. | 2020-09-29 |
| 32989908 | The aim of this study was to evaluate the incidence of venous thromboembolism (VTE) in patients with COVID-19 admitted to both intensive care units (ICUs) and medical wards (MWs). | 2020-09-29 |
| 32989938 | Convalescent plasma has been used for decades to prevent and treat a wide range of infectious diseases for which no specific treatment is available. […] Several small and large-scale studies have shown the effects of convalescent plasma for the treatment of severe coronavirus disease 2019 (COVID-19). […] In addition to transfusion-related side effects, unexpected side effects such as antibody-dependent enhancement (ADE) may occur during convalescent plasma therapy, but early safety studies have not found any cases of ADE among more than 5,000 participants. […] With historical precedents and recent clinical studies, convalescent plasma therapy should be considered as a candidate therapy for COVID-19 given the limited effectiveness of antiviral drugs and lack of a vaccine. […] Further clinical trials should be conducted to determine the safety and efficacy of convalescent plasma therapy concurrently with its clinical use. | 2020-09-29 |
| 32989997 | Treatment with interferon inhalation showed no clinical effect and the condition worsened instead (Tab. | 2020-09-29 |
| 32989998 | This article offers few insights on scattered issues; including the clinical characteristics, pathology and diagnosis, as well as treatment perspectives and public health approach. […] Focusing healthcare resources on necessary treatment and prevention and combining efforts for developing feasible solutions will be decisive for time needed to achieve worldwide containment (Tab. | 2020-09-29 |
| 32989999 | The remote diagnosis (mail, phone or video-call) and treatment methods that can be expected in the near future may be even closer with the Corona virus (Tab. | 2020-09-29 |
| 32990100 | At present there are no successful therapeutics against SARS-CoV-2; existing antiviral therapies have been utilized to hinder manifestation of respiratory difficulties by diminishing viral load. […] Herein, we depict an extensive update on the clinical aspects of COVID-19, including strategies for the regulation of the transmission, diagnosis, treatment, and pathogenesis of SARS-CoV-2 infections. | 2020-09-29 |
| 32990149 | According to the diagnosis and treatment plan, the included cases were classified into mild, moderate, severe, and critical. […] Clinicians need to closely monitor coagulation and liver function tests and to give prophylactic or supportive therapy when needed. | 2020-09-29 |
| 32990161 | Therefore, this is a safe and convenient screening tool for SARS-CoV-2, and it may promote the development of COVID-19 vaccines and therapeutics. | 2020-09-29 |
| 32990177 | Basic reproduction number, R 0 , was determined in which its numerical results revealed that, in the presence of face masks wearing and medication services or hospitalization as preventive measure for its transmission, R 0 = 0.698 while in their absence R 0 = 3.8 . | 2020-09-29 |
| 32990193 | The corona virus pandemic has made the treatment of all cancers difficult. […] Treatment modalities including chemotherapy and targeted therapies can weaken the immune system and then cause serious or lethal coronavirus infections. | 2020-09-29 |
| 32990239 | To investigate the status of anxiety and depression in patients requiring emergency treatment during the epidemic of COVID-19 to identify the patients with acute psychological stress disorder. […] Among the patients visiting the emergency treatment, the patients with suspected COVID-19 and common fever are more likely to develop anxiety and depressive symptoms. | 2020-09-29 |
| 32990580 | To explore the effect of atrial septal defect (ASD) and venoarterial extracorporeal membrane oxygenation (VA-ECMO) in the treatment of ARDS combined with left ventricular dysfunction (LVD) to find a new effective method for treating severe COVID-19 patients. […] ASD plus VA-ECMO is an effective method for the treatment of ARDS combined with LVD, which is the main cause of death in severe COVID-19 patients. | 2020-09-29 |
| 32990864 | The SpO2 returned to pre-treatment values when the surgical mask was removed confirming the effect of the device rather than a spontaneous positive evolution. | 2020-09-29 |
| 32991035 | All subjects recovered from COVID-19 should undergo long-term monitoring for evaluation and treatment of symptoms and conditions that might be precipitated with the new coronavirus infection. | 2020-09-29 |
| 32991251 | Herein, we discuss the genetics, pathogenesis, and possible therapeutics of COVID-19 infection along with secondary complications associated with disease progression, including ARDS and pulmonary fibrosis. | 2020-09-29 |
| 32991426 | A systematic and comprehensive understanding of their relationship is essential to provide public health prevention or treatment strategy. | 2020-09-29 |
| 32991438 | External treatment of traditional Chinese medicine includes acupuncture, massage, fire needle, cupping, and other alternative therapies. […] We will search the randomized controlled trials related to the external treatment of traditional Chinese medicine (such as, acupuncture, massage, etc) and COVID-19 from inception to June 2020. […] Primary outcomes include the influence of external treatment of traditional Chinese medicine on the patients with COVID-19. […] The conclusion of our study will provide evidence to judge whether external treatment of traditional Chinese medicine is an effective intervention on the patients with COVID-19. | 2020-09-29 |
| 32991573 | BACKGROUND There is no evidence-based treatment for coronavirus disease 2019 (COVID-19). […] The therapy with convalescent plasma led to clinical improvement and normalization of inflammatory parameters. […] CONCLUSIONS This report presents a case of severe COVID-19 pneumonia in a 63-year-old woman who was given supportive treatment with convalescent plasma. […] Ongoing clinical trials will determine whether convalescent plasma therapy is an effective treatment for SARS-CoV-2 infection. | 2020-09-29 |
| 32991844 | Our results explain the immunodominance of the receptor-binding motif and will guide the design of COVID-19 vaccines and therapeutics. | 2020-09-29 |
| 32991870 | To report the cognitive features of patients with severe coronavirus disease 2019 (COVID-19) entering the postacute phase, to understand whether COVID-19 acute respiratory distress syndrome itself could result in long-term cognitive deficits, and to determine whether neuropsychological treatment after the acute stage might represent a specific rehabilitation need. | 2020-09-29 |
| 32991873 | Allocation schema for mechanical ventilators, intensive care unit resources, blood components, novel therapeutics, extracorporeal membrane oxygenation, and renal replacement therapies were developed. | 2020-09-29 |
| 32991900 | The emergence of the global pandemic caused by the novel SARS-CoV-2 virus has motivated scientists to find a definitive treatment or a vaccine against it in the shortest possible time. […] All the above-mentioned strategies, as well as the role of nanomedicine for the diagnosis and treatment of SARS-CoV-2 infection, have been discussed in this review. | 2020-09-29 |
| 32992075 | INSPIRATION and INSPIRATON-S studies will help address clinically-relevant questions for antithrombotic therapy and thromboinflammatory therapy in critically-ill patients with COVID-19. | 2020-09-29 |
| 32992199 | Numerous case reports and retrospective cohort studies have been published with mixed characteristics of COVID-19 patients with stroke regarding age, comorbidities, treatment, and outcome. | 2020-09-29 |
| 32992235 | Scientists are scrambling for ideas to develop treatment and prevention strategies to thwart the disease condition. […] In this review, we have attempted to summarize the latest information on the virus, disease, prevention, and treatment strategies. | 2020-09-29 |
| 32992245 | Urgent treatments, in any modality, to fight SARS-CoV-2 infections are desired by society in general, by health professionals, by Estate-leaders and, mainly, by the scientific community, because one thing is certain amidst the numerous uncertainties regarding COVID-19: knowledge is the means to discover or to produce an effective treatment against this global disease. | 2020-09-29 |
| 32992323 | Our results highlight the need for priority of early detection and testing, and early therapy for people with obesity and COVID-19 infections. | 2020-09-29 |
| 32992409 | In this review, we discussed the virology, epidemiological data, the replication of the virus, and its relationship with cardiovascular diseases on COVID-19 pandemics, treatment and vaccines. […] Thereby, this study aims to neatly present scientific data in light of many regarding literature that can be a clue for readers who research this disease prevention and treatment. | 2020-09-29 |
| 32992435 | The primary treatments in acute phase are antiviral therapy and supportive treatment. | 2020-09-29 |
| 32992436 | Objective: To investigate the application of severity classification according to the protocol on the Diagnosis and Treatment of coronavirus disease 2019(COVID-19)by the National Health Commission of China, pneumonia severity index(PSI) and CURB-65 in risk stratification and prognostic assessment of COVID-19. […] Patients were divided into 3 groups (common, severe, and critical type) at admission according to the sixth version of the protocol issued by the National Health Commission of China on Diagnosis and Treatment of COVID-19. | 2020-09-29 |
| 32992693 | The purpose of this narrative review is to critically assess and discuss pharmaconutrition strategies that, secondary to accepted treatment methods, could be candidates in the current context of COVID-19. | 2020-09-30 |
| 32992744 | Although a few pharmacological agents (e.g., bimagrumab, sarconeos, and exercise mimetics) are being explored in different stages of trials, not a single drug has been approved for sarcopenia treatment. | 2020-09-30 |
| 32992752 | A 42-year old male patient presented with sudden respiratory insufficiency during arthroscopic knee lavage and subsequently required highly invasive ventilation therapy and catecholamine administration. | 2020-09-30 |
| 32992775 | This review discusses the epidemiology, transmission, and clinical presentation of COVID-19 with a focus on its pathogenesis and the possible use of liposomal GSH as an adjunctive treatment to the current treatment modalities in COVID-19 patients. | 2020-09-30 |
| 32992807 | There were more women (χ2 = 6.42, p = 0.02) in the group of people with high results in the GHQ-28 questionnaire and the differentiating factors between those with sten scores above 7 (significantly deteriorated mental health) and those with average or low results (sten score below 7) turned out to be: treatment for mental disorders before the pandemic (χ2 = 19.57, p < 0.001) and the use of psychotherapy during the pandemic (χ2 = 4.21, p = 0.04) and psychiatric pharmacotherapy (χ2 = 8.31, p = 0.01). […] The risk factors for the deterioration of the mental state of the respondents during the pandemic include psychiatric treatment before the beginning of the pandemic, the presence of suicidal thoughts during forced isolation, and the use of non-adaptive coping strategies (denial of the existence of problems, emotional discharge, use of psychoactive substances, discontinuation of action, and blaming oneself for the situation). | 2020-09-30 |
| 32993146 | These promising natural products have efficiency in developing new drugs necessary in the treatment of various deadly pathologies (cancer, HIV, SARS-CoV-2, several inflammations, etc.). | 2020-09-30 |
| 32993173 | Scientists and pharmaceutical companies have promptly responded by advancing potential therapeutics into clinical trials at an exponential rate. […] Yet, the research continues so as to identify better clinically relevant therapeutics that act either as prophylactics to prevent the infection or as treatments to limit the severity of COVID-19 and substantially decrease the mortality rate. […] Previously, we reviewed the potential therapeutics in clinical trials that block the early stage of the viral life cycle. […] In this review, we summarize potential anti-COVID-19 therapeutics that block/inhibit the post-entry stages of the viral life cycle. […] The review presents not only the chemical structures and mechanisms of the potential therapeutics under clinical investigation, i.e., listed in clinicaltrials.gov, but it also describes the relevant results of clinical trials. […] The reviewed therapeutics include small molecules, polypeptides, and monoclonal antibodies. […] At the molecular level, the therapeutics target viral proteins or processes that facilitate the post-entry stages of the viral infection. […] Overall, we aim at presenting up-to-date details of anti-COVID-19 therapeutics so as to catalyze their potential effective use in fighting the pandemic. | 2020-09-30 |
| 32993690 | COVID-19 in Italy has led to the need to reorganize hospital protocols with a significant risk of interruption to cancer treatment programs. […] During both phases of the COVID-19 emergency, the planned model used in our own experience guaranteed both continuity in radiotherapy treatments whilst neither reducing workload nor interrupting treatment and, as such, it ensured the safety of cancer patients, hospital environments and staff. | 2020-09-30 |
| 32993751 | This study shows that TCZ treatment may be effective in COVID-19 patients with severe respiratory impairment receiving NIV. | 2020-09-30 |
| 32993779 | There is a lack of evidence-based targeted pharmacological therapy for its prevention and treatment. | 2020-09-30 |
| 32993804 | It is important to reinforce the primacy of high-quality trials in generating unbiased answers to pressing prevention and treatment questions about COVID-19. | 2020-09-30 |
| 32993921 | In addition, no significant differences were observed with the length of stay, Urology department admission requirement and type of therapy. […] However, we did not find any significant difference with the length of stay, Urology department admission requirement and type of therapy. | 2020-09-30 |
| 32994047 | The COVID-19 pandemic has called attention to the contribution of comorbidities, including cancer and brought additional challenges to previously existing programs for cancer treatment and control. | 2020-09-30 |
| 32994052 | Imaging techniques, especially computed tomography pulmonary angiography, can well solve this puzzle and lead to timely treatment of these patients. | 2020-09-30 |
| 32994125 | Since there aren’t any definite treatment guidelines established in children with severe COVID, treatment is guided by adult recommendations which too are often not evidence based. […] The use of convalescent plasma along with steroids and IVIG showed dramatic results in this child and she recovered without the need for any specific treatment. | 2020-09-30 |
| 32994151 | Patients with cancer and recent cancer treatment (chemotherapy or surgery) and SARS-CoV-2 infection have a higher risk of worse outcomes. | 2020-09-30 |
| 32994187 | Treatment with sitagliptin at the time of hospitalization was associated with reduced mortality (18% vs. 37% of deceased patients; hazard ratio 0.44 [95% CI 0.29-0.66]; P = 0.0001), with an improvement in clinical outcomes (60% vs. 38% of improved patients; P = 0.0001) and with a greater number of hospital discharges (120 vs. 89 of discharged patients; P = 0.0008) compared with patients receiving standard of care, respectively. […] In this multicenter, case-control, retrospective, observational study of patients with type 2 diabetes admitted to the hospital for COVID-19, sitagliptin treatment at the time of hospitalization was associated with reduced mortality and improved clinical outcomes as compared with standard-of-care treatment. | 2020-09-30 |
| 32994364 | Understanding humoral responses to SARS-CoV-2 is critical for improving diagnostics, therapeutics, and vaccines. | 2020-09-30 |
| 32994372 | As no vaccine or specific antiviral is currently available, management plans include supportive treatment. | 2020-09-30 |
| 32994700 | The aim of the study was to evaluate the association between chronic kidney disease (CKD) and new onset renal replacement therapy (RRT) with the outcome of Coronavirus Disease 2019 (COVID-19) in patients. | 2020-09-30 |
| 32995261 | The management of the disease was done at home with methylprednisolone (MP) pulse therapy for three days. […] Studies using pulse MP as treatment for SARS-CoV-1 showed clinical improvement and decreased incidence of ARDS compared with patients who received low dose steroid treatment. | 2020-09-30 |
| 32995318 | Nevertheless, we should reassess the need for induction therapy across the board for ordinary patients and the more liberal use of mammalian target of rapamycin inhibitors in transplant patients with proven infection. | 2020-09-30 |
| 32995369 | We describe the unique experience and favorable outcome of a 100-year-old COVID-positive hip fracture patient that underwent spinal anesthesia for hemiarthroplasty and subsequent hydroxychloroquine (HCQ) therapy. […] Multiple factors of varying known benefit may have contributed to our outcome, including preoperative medical consultation and assessment, early surgical intervention, regional anesthesia with little to no sedation, early mobilization and HCQ therapy. | 2020-09-30 |
| 32995668 | Using the IAEA guidelines, the %RT accessibility and the additional requirements of teletherapy (TRT) units were computed for these countries. | 2020-09-30 |
| 32995708 | This was a two-center retrospective, observational trial carried out in the intensive care units of the hospitals of Bolzano and Merano, Italy, from March 15 to April 20, 2020. | 2020-09-30 |
| 32995736 | This review investigates recent literature published about the use of non-pharmacologic modalities for stress relief in pregnancy and examines the interplay between psychiatric diagnoses and stressors, with the purpose of evaluating the feasibility of implementing non-pharmacologic interventions as sole therapies or in conjunction with psychotherapy or psychiatric medication therapy. […] Further, the effectiveness of each non-pharamacologic therapy in reducing symptoms of maternal stress is reviewed. | 2020-09-30 |
| 32996368 | AI-based tools can be a game-changer for diagnosis, treatment, and management of COVID-19 patients with the potential to reshape the future of healthcare in LMIC. | 2020-09-30 |
| 32996705 | Countries with high HIV burden are balancing the need to minimize interactions with health facilities to reduce the risk of COVID-19 transmission, while delivering uninterrupted essential HIV prevention, testing and treatment services. […] HIV treatment service adaptations for families should focus on family based differentiated service delivery models, including community-based ART initiation and multi-month ART dispensing. […] Viral load monitoring should not be a barrier to transitioning children and adolescents experiencing treatment failure to more effective ART regimens, and viral load monitoring for pregnant and breastfeeding women and children should be prioritized and bundled with other essential services. […] Tailored, family friendly programme adaptations for case-finding, ART delivery and viral load monitoring for these populations have the potential to limit SARS-CoV-2 transmission while ensuring the continuity of life-saving HIV case identification and treatment efforts. | 2020-09-30 |
| 32996727 | In this cohort study performed in February-May 2020 in a large teaching hospital in Milan, COVID-19 patients with adult respiratory distress syndrome receiving continuous positive airway pressure (positive end-expiratory pressure = 10 cm H2O, FiO2 = 0.6, daily treatment duration: 4x3hcycles) and respiratory physiotherapy including pronation outside the intensive care unit were followed up. | 2020-09-30 |
| 32996826 | Gynaecologists are not considered front-line staff in the treatment of the novel coronavirus unlike our intensive care or accident and emergency colleagues. […] This article summarises the strategies developed at King’s College Hospital to remodel services to best provide optimum treatment to patients in this new era. | 2020-09-30 |
| 32996834 | The presence of hypercoagulation status in critical COVID-19 patients should be observed closely, and anticoagulation therapy can be considered in selected patients. […] More clinical data are needed to examine the role of anticoagulation in COVID-19 treatment. | 2020-09-30 |
| 32996851 | Flexibility in the psychotherapeutic frame of treatment arises from many sources, from the general to the personal, and can take several forms. […] This article looks at walking while conducting psychotherapy with patients and explores the ways in which flexibility in treatment can enhance the alliance, how walking side by side brings the body into focus with its implications for transference and countertransference, and how associations to landscape evoke past memories and access emotions. […] Since writing this article, the coronavirus pandemic has swept across the world and required psychotherapists everywhere to bend the frame of treatment and meet with patients virtually-by phone or video conference-to maintain social distancing and prevent the spread of infection. […] The hardships posed by this shift in treatment frame combine with benefits not dissimilar to those found with psychotherapy while walking. | 2020-09-30 |
| 32996862 | Main challenges were uncertainty and anxiety among staff, relative scarcity of equipment and workforce resources and rapid implementation of new requirements for treatment capacities. | 2020-09-30 |
| 32997237 | This study investigates the association between the treatment with hydroxychloroquine and mortality in patients admitted with COVID-19. […] The following variables were extracted for this study: age, gender, temperature, and saturation of oxygen on admission, treatment with hydroxychloroquine, azithromycin, heparin, steroids, tocilizumab, a combination of lopinavir with ritonavir, and oseltamivir, together with data on mortality. | 2020-09-30 |
| 32997322 | Currently, there is no effective anti-SARS-CoV-2 drug approved worldwide for treatment of patients with COVID-19. | 2020-09-30 |
| 32997333 | Currently, there are no markers to guide antithrombotic therapy in Covid-19. | 2020-09-30 |
| 32997438 | Medication adherence was maintained, and limitations in access to care were partly counterbalanced by use of telehealth. | 2020-09-30 |
| 32997448 | Can we administer a life-saving treatment that could impact negatively the patient’s quality of life when the patient isn’t able to give consent? […] During this Covid-19 period, can the use of chemical or physical restraints be considered as mistreatment, whereas the aim is to protect others? | 2020-09-30 |
| 32997537 | The summary recommendations are divided into different categories, including risk minimization; care prioritization of patients; health care team management; virtual care; management of patients with cancer undergoing surgical, radiation, and systemic therapy; clinical research; and recovery plans. | 2020-09-30 |
| 32997540 | Evidence-based treatment protocols, dispensable by teleoncology, already exist for many sites of cancer and they can provide a bridge to treatment when patients are unable to reach cancer centers for their standard treatment. | 2020-09-30 |
| 32997542 | Identification of patients with novel coronavirus disease 2019 (COVID-19) requiring hospital admission or at high-risk of in-hospital mortality is essential to guide patient triage and to provide timely treatment for higher risk hospitalized patients. | 2020-09-30 |
| 32997720 | Then, we show that the WAR framing is used to talk about specific topics, such as the virus treatment, but not others, such as the effects of social distancing on the population. | 2020-09-30 |
| 32997749 | We report the first case of PIMS-TS in a child on established anti-Tumor Necrosis Factor-alpha (anti-TNF-α) therapy; a 10 year-old girl with ulcerative colitis treated with infliximab. […] The condition was refractory to treatment with intravenous immunoglobulin (IVIG) but improved within 24hrs of high dose methylprednisolone. […] Infliximab treatment followed and the patient has remained well at follow up. […] Accepting the wide spectrum of PIMS-TS presentations, it is possible that prior anti-TNF-α therapy may have attenuated the disease course. […] Given the uncertainty around therapeutic strategies for PIMS-TS this case supports the need for further investigation into continuing infliximab as a treatment option for the condition. | 2020-09-30 |
| 32997808 | In this review, we discuss recent publications on asthma and review the studies that have reported on the different aspects of the prevalence, risk factors and prevention, mechanisms, diagnosis, and treatment of asthma. […] The most relevant experimental studies further advancing the understanding of molecular and immune mechanisms with potential new targets for the development of therapeutics are discussed. […] Novel approaches and strategies in asthma treatment linked to mechanisms and endotypes of asthma, particularly biologicals, are critically appraised. | 2020-09-30 |
| 32998066 | As effective point-of-care diagnosis tools, simple, low-cost and rapid sensors have the potential to greatly accelerate the screening and diagnosis of suspected patients to improve their treatment and care. | 2020-09-30 |
| 32998213 | With recent advancements in robotics, innovative diagnostic and treatment devices have been developed and several translational attempts made. […] Although the existing endoscopic devices have thus far provided substantial improvements in the effectiveness of diagnosis and treatment, there are certain aspects that represent unwavering predicaments of the current gastroenterology practice. […] The combination of robotics and artificial intelligence, as well as remote telehealth endoscopy services, are also discussed, as viable solutions to improve existing platforms for diagnosis and treatment are emerging. | 2020-10-01 |
| 32998368 | This review summarizes the structural features of CoV PLpro, the inhibitors that have been identified over the last 20 years, and the compounds that have the potential to become novel effective therapeutics against CoVs in the near future. | 2020-10-01 |
| 32998369 | TAM targeting is becoming an interesting biomedical strategy, which is useful for COVID-19 treatment now, but also for other viral and inflammatory diseases in the future. | 2020-10-01 |
| 32998398 | In the future, well-designed studies are needed to better understand the risk of stroke in COVID-19, to optimize treatment, and to improve stroke care. | 2020-10-01 |
| 32998403 | Given the close person-to-person contact involved in delivering dental care and treatment procedures that produce aerosols, dental healthcare professionals including dentists, dental assistants and dental hygienists are at high risk of exposure. […] As a dental clinic in a comprehensive cancer center, we have continued to safely provide medically necessary and urgent/emergent dental care to ensure that patients can adhere to their planned cancer treatment. | 2020-10-01 |
| 32998491 | The proportion of hospitalised patients with asthma, other chronic respiratory disease, cardiovascular disease, ongoing cancer treatment, complications related to hypertension, obesity and overweight, neurological disorders and cardiac and renal failure was also higher than in the general population. | 2020-10-01 |
| 32998618 | The inhibitory effect of all studied compounds was studied with compared to some proposed antiviral drugs which currently used in COVID-19 treatment such as chloroquine, hydroxychloroquine, azithromycin, remdesivir, baloxvir, lopinavir, and favipiravir. […] So, this study suggested that caulerpin could be used as a potential candidate in COVID-19 treatment. | 2020-10-01 |
| 32998840 | These cases suggest that in the COVID-19 pandemic period, to provide an earlier specific treatment in patients with positive serology, a chest CT scan can be useful in those presenting with a fever or a history of fever associated with persistent mild respiratory symptoms or with abdominal complaints despite repeated negative RT-PCR results. | 2020-10-01 |
| 32998872 | Intensive care units at 68 geographically diverse hospitals across the United States. | 2020-10-01 |
| 32999229 | Tocilizumab (TCZ; Actemra/RoActemra) is an anti-IL-6 receptor antibody for the treatment of rheumatoid arthritis (RA) and other autoimmune diseases and cytokine storms. | 2020-10-01 |
| 32999264 | Their demographics, symptoms, laboratory findings, comorbidities, concomitant drugs, treatment, and clinical course were reviewed. | 2020-10-01 |
| 32999267 | These symptoms may be due to venous thrombosis following SARS-CoV-2 vasculitis, leading to challenging decisions regarding anticoagulation therapy. | 2020-10-01 |
| 32999768 | The drug list obtained includes inhibitors of HIV, hepatitis C, and cytomegalovirus (CMV), as well as a set of drugs that have demonstrated some activity in MERS, SARS-CoV, and SARS-CoV-2 therapy. […] We recommend testing of the selected compounds for treatment of COVID-19. | 2020-10-01 |
| 32999777 | Overall, 39% of the subjects did not need respiratory support, while 13% were on a ventilator, 16% on bilevel positive airway pressure/continuous positive airway pressure (BiPAP/CPAP), and 31% on supplemental oxygen therapy. | 2020-10-01 |
| 32999889 | We report the case of an 18-year-old ulcerative colitis patient in sustained clinical remission who 4 days after application of her ongoing therapy with the anti-TNF antibody infliximab developed mild respiratory and abdominal symptoms. […] The recently applied anti-TNF therapy did not lead to exacerbation of the infectious symptoms. […] Current recommendations strongly favor continuation of effective maintenance anti-TNF therapy in inflammatory bowel disease patients, as there is no evidence for aggravated CO-VID-19 upon infection. […] It is unclear whether anti-TNF treatment might even have assisted in preventing worsening of COVID-19 and improving outcome. […] Further data in the group of immune-mediated inflammatory disease patients under anti-TNF therapy are urgently needed. | 2020-10-01 |
| 33000106 | Singapore was one of the first countries affected by the coronavirus disease 2019 (COVID-19) pandemic but has been able to prevent its healthcare system and intensive care units (ICU) from being overwhelmed. | 2020-10-01 |
| 33000107 | The clinical, epidemiological, laboratory, treatment and outcome data of patients were evaluated. […] Inflammatory markers such as C-reactive protein, D-dimer, ferritin, fibrin degradation product and interleukin-6 were significantly elevated (P <0.05) in patients who required oxygen therapy than those who did not require it, suggesting the potential role such markers could play in predicting prognosis in patients. […] Without a proven therapy to combat this pandemic and with no sight of vaccines in the near future, a preventive strategy should be adopted to contain the spread of this infectious disease. | 2020-10-01 |
| 33000172 | We used pre-post differences in dengue case counts and exploited heterogeneity in SD treatment effects among different age groups in Singapore to identify the spillover effects of SD measures. | 2020-10-01 |
| 33000518 | The novel PPE approach was able to prevent staff from becoming infected during the pandemic despite the fact that several parents, and subsequently their children, became infected with Covid-19 during cancer treatment at the facility. | 2020-10-01 |
| 33000663 | The Audiology Department at the Royal Surrey County Hospital usually offers face-to-face audiologist-delivered cognitive behavioural therapy (CBT) for tinnitus rehabilitation. | 2020-10-01 |
| 33000673 | When asked about defining an age limit for providing patients with scarce resources (such as ventilation machines) in cases of insufficient supplies, respondents stated that the maximum age in such scenarios should be 84 (standard deviation (SD = 19) - yet most respondents (81.4%) believed that every patient has the right to receive optimal treatment, regardless of their age and medical background. | 2020-10-01 |
| 33000931 | After receiving short-term inpatient rehabilitation therapy, lower limb muscle strength, balance function, and gait speed had rapidly and significantly improved at the time of hospital discharge and at 1-month follow-up. | 2020-10-01 |
| 33000932 | A monthly systematic review update is carried out to maintain the currency of scientific literature on rehabilitation of patients with COVID-19 and/or describing consequences due to the disease and its treatment, as they relate to limitations in functioning of rehabilitation interest. | 2020-10-01 |
| 33001004 | The viral infection continues to impact the globe with no vaccine to prevent the infection or highly effective therapeutics to treat the millions of infected people around the world. […] In this article, we summarize the potential of dipyridamole as an adjunct therapy for COVID-19. […] Dipyridamole may substantially help improve the clinical outcomes of COVID-19 treatment. | 2020-10-01 |
| 33001008 | Traditional Chinese medicine (TCM) has been introduced for the treatment of COVID-19. […] However, efficacy differs among herbal medicines, and the ideal prescription pattern for TCM herbal formulae for COVID-19 treatment needs to be explored. […] The aim of this study was to analyze the TCM prescription pattern in Regional Schemes in China for COVID-19 in order to provide a new reference for the use of TCM in COVID-19 treatment. […] By searching the TCM treatment protocols of COVID-19 in 23 Regional Schemes, TCM syndromes and herbal medicines were analyzed by data mining. […] In the middle stage, the treatment priority is clearing heat and resolving toxins, promoting lung function, and relieving asthma. […] In the recovery stage, the main treatment is to invigorate the spleen and regulate Qi, tonify Qi, nourish Yin, and clear residual disease evil. […] This study may help to improve understanding of TCM herbal prescription pattern, practices, reveal the efficacy of combinations of Chinese herbs, and provide new ideas for TCM treatment for COVID-19. | 2020-10-01 |
| 33001051 | The disease has a higher mortality compared to other viral agents causing pneumonia and unfortunately, no approved specific therapy, nor vaccine has yet been discovered. | 2020-10-01 |
| 33001138 | This randomized, double-blind, placebo-controlled clinical trial (the Prevention and Treatment of COVID-19 With Hydroxychloroquine Study) was conducted at 2 tertiary urban hospitals, with enrollment from April 9, 2020, to July 14, 2020; follow-up ended August 4, 2020. […] The primary outcome was the incidence of SARS-CoV-2 infection as determined by a nasopharyngeal swab during the 8 weeks of treatment. […] Secondary outcomes included adverse effects, treatment discontinuation, presence of SARS-CoV-2 antibodies, frequency of QTc prolongation, and clinical outcomes for SARS-CoV-2-positive participants. […] Mild adverse events were more common in participants taking hydroxychloroquine compared with placebo (45% vs 26%; P = .04); rates of treatment discontinuation were similar in both arms (19% vs 16%; P = .81). | 2020-10-01 |
| 33001323 | HY-CBt-p is delivered over fewer sessions than formulation-based Cognitive Behavioral Therapy for psychosis (CBTp), can be learned by a range of providers, and includes techniques such as developing a normalizing explanation; techniques to reduce anxiety, depression, and insomnia, which perpetuate psychotic symptoms; self-monitoring; reality testing; and wellness planning. | 2020-10-01 |
| 33001329 | Patient reported outcomes (PROs) were analyzed of patients living with HIV/HCV co-infection (n = 313) who presented for clinical evaluation and treatment of HCV between 2013 and 2017 at a university-affiliated HIV/HCV Co-infection Clinic. | 2020-10-01 |
| 33001376 | The presence of comorbidity poses a major clinical challenge in the care and treatment of COVID-19 patients. | 2020-10-01 |
| 33001407 | This study aimed at observing whether the COVID-19 related lockdown influenced migraine frequency and disability in migraine patients on therapy with monoclonal antibodies inhibiting the CGRP pathway. […] Patients beyond the first 3 months of therapy presented less often a reduction in MMDs (p = .006) and on everyday life did not affect the migraine load in patients receiving monoclonal antibodies inhibiting the CGRP pathway. […] Patients in the first months of therapy experienced a greater improvement according to drug pharmacokinetics, while women more frequently needed rescue medications, possibly indicating presenteeism or cephalalgophobia. | 2020-10-01 |
| 33001409 | A significant univariate association between age; sex; body mass index; smoking; diabetes; cardiovascular, pulmonary, neurological, and kidney diseases; ACE inhibitor therapy; statin intake and an increased risk for complicated clinical stages of COVID-19 at diagnosis was found. […] Further data regarding outcomes of the natural course of COVID-19 and the influence of treatment are required. | 2020-10-01 |
| 33001783 | With the growing global COVID-19 outbreak, a comprehensive understanding of the diagnostic imaging hallmarks, imaging features, multisystemic involvement, and evolution of imaging findings is essential for effective patient management and treatment. | 2020-10-01 |
| 33001829 | However, there is also inaccurate information that vaping can aid COVID-19 treatment, and expert opinion that CBD, possibly administered through vaping, can mitigate COVID-19 symptoms. […] Inaccurate information about vaping and COVID-19 may affect COVID-19 treatment outcomes. […] Broadly, the online vaping narrative could be organized into the following groups or archetypes: 1) Harms from vaping; 2) Vaping regulation; 3) Vaping as harm reduction/treatment; 4) Vaping lifestyle. […] There were three archetypes pre-COVID-19, but four archetypes post-COVID-19 (vaping as harm reduction/treatment was the additional archetype). […] There was an emergence of a CBD product preference topic post-COVID-19 report, possibly related to vapers using CBD as a COVID-19 treatment. […] Our main finding is the emergence of a vape-administered CBD treatment narrative around COVID-19, when comparing the pre-COVID-19 versus during COVID-19 online vaping narrative. […] Results are key to understanding how vapers respond to inaccurate information about COVID-19, allowing for optimized treatment of vapers who contract COVID-19, and possibly minimizing instances of inaccurate information. | 2020-10-01 |
| 33001835 | The COVID-19 pandemic has necessitated an immediate and large-scale uptake of online treatment for mental health care. […] To what extent will the experiences gained during the pandemic influence a sustainable adoption and implementation of online mental health care treatment in the future? […] Due to skill enhancement and (unexpected) positive experiences with online treatment, an increase in adoption is likely to take place. […] However, not all experiences promise a successful and sustainable upscaling of online treatment in the future. […] Mental health care professionals are learning that not all clients are able to benefit from this type of treatment. […] Online treatment could work for those who are open to it, but many factors influence whether it will work in specific situations. […] There is work to be done before online treatment is inherently part of mental health care. | 2020-10-01 |
| 33001836 | In the process of the prevention and control of COVID-19 in China, big data technology has played an important role in personal tracking, surveillance and early warning, tracking of the virus’s sources, drug screening, medical treatment, resource allocation, and production recovery. | 2020-10-01 |
| 33001838 | The most searched information included accessing medical treatment, managing self-quarantine, and offline to online support. | 2020-10-01 |
| 33001967 | Our findings suggest that recent loss of smell is a highly specific COVID-19 symptom and should be considered more generally in guiding case isolation, testing, and treatment of COVID-19. | 2020-10-01 |
| 33002032 | As of now, no registered therapies are available for treatment of coronavirus infection. | 2020-10-01 |
| 33002478 | Clinical outcomes of severe COVID-19 included hospitalization, a requirement for treatment in an intensive care unit (ICU), invasive mechanical ventilation (IMV), and mortality. | 2020-10-01 |
| 33002516 | This concept may have important implications for future COVID-19 diagnostics and immune-based therapy developments. | 2020-10-01 |
| 33002521 | Preliminary observations on anticoagulant therapy appear to be associated with better outcomes in moderate and severe COVID-19 patients with signs of coagulopathy and in those requiring mechanical ventilation. […] The pathophysiology underlying the prothrombotic state elicited by SARS-CoV-2 outlines possible protective mechanisms of antithrombotic therapy (in primis anticoagulants) for this viral illness. […] The indications for antiplatelet/anticoagulant use (prevention, prophylaxis, therapy) are guided by the clinical context and the COVID-19 severity. […] We provide a practical approach on antithrombotic therapy management for COVID-19 patients from a multidisciplinary point of view. | 2020-10-01 |
| 33002544 | The recent COVID-19 pandemic has accelerated the treatment process through IT/technological supports, useful in the management of chronic patients such as those affected by type 1 Diabetes Mellitus (T1DM). | 2020-10-01 |
| 33002549 | Patients were surveyed on the effects of COVID-19 on their fast, discussions with a healthcare professional (HCP) before Ramadan, whether they followed advice, number of fasts undertaken, medication changes and adverse events. 829 participated. | 2020-10-01 |
| 33002611 | Furthermore, comparing with later initiation of convalescent blood product therapy, earlier initiation of convalescent blood product therapy might decrease the rate of mortality. | 2020-10-01 |
| 33002613 | Respiratory parameters seven days after receiving tocilizumab therapy were compared to baseline measurements. […] Tocilizumab was administered to 125 patients: 65 received IV, and 60 received SC therapy. […] At the doses used in this study, IV tocilizumab is preferred over SC therapy to treat cytokine storm syndrome due to COVID-19. | 2020-10-01 |
| 33002725 | The patient responded well to pulse steroid therapy and plasmapheresis in both occasions. | 2020-10-01 |
| 33002740 | Results of the present study shed light on role of IL-18 on COVID-19 pathogenesis and might provide an evidence for the clinical trials on IL-18 antagonists for the treatment of severe COVID-19 patients. | 2020-10-01 |
| 33002914 | The early wave of patients in Singapore with severe pneumonia requiring intensive care units (ICU) are gradually being referred for post-critical illness management with our inpatient medical rehabilitation unit. | 2020-10-01 |
| 33002954 | No specific antiviral treatment is currently available. […] Short course of stress dose of corticosteroids might be used as adjunctive treatment to patients who are late presenters with cytokine storm. […] Convalescent plasma from recovered COVID-19 patients with high neutralizing antibody might also be beneficial in the treatment of severe disease. […] Early effective antiviral therapy in COVID-19 patients will suppress the SARS-CoV-2 viral load. […] Adjunctive therapy with corticosteroid and convalescent plasma might further ameliorate the cytokine response. […] Further randomized clinical trials of combination therapy are needed. | 2020-10-01 |
| 33003053 | The novel coronavirus pandemic and the resulting expanded use of telemedicine have temporarily transformed community-based care for individuals with serious mental illness (SMI), challenging traditional treatment paradigms. | 2020-10-01 |
| 33003102 | Immune modulatory treatment was thus considered. | 2020-10-01 |
| 33003128 | Meanwhile, staff were stretched to care for exponentially rising case volume as COVID intensive care units (ICUs) expanded. | 2020-10-01 |
| 33003134 | To evaluate the effect of hormone therapy on clinical outcomes among women, subgroup analyses using age-matched case-control data were performed. […] Men were more likely to receive oxygen therapy (144 [6.46%] vs 131 [4.63%], P = 0.004), be admitted to the intensive care unit (60 [2.69%] vs 53 [1.87%], P = 0.049), and have a longer length of stay after admission to the intensive care unit (19.70 ± 11.80 vs 14.75 ± 9.23, P = 0.016). […] Hormone therapy was not significantly associated with clinical outcomes. | 2020-10-01 |
| 33003176 | Our protocol was developed in order to identify cases of multisystem inflammatory syndrome in children with high sensitivity, stratify risk to guide treatment, recognize co-infectious or co-inflammatory processes, mitigate coronary artery abnormalities, and manage hyperinflammatory shock. […] Treatment centers around glucocorticoids and IV immunoglobulin with biologic immunomodulators as adjuncts. […] Multidisciplinary follow-up after discharge is indicated to manage continued outpatient therapy and evaluate for disease sequelae. […] After institution of this protocol, patients received earlier treatment and had shorter lengths of hospital stay. […] Instituting such a protocol during a global pandemic is feasible and is associated with patients receiving treatment and returning home more quickly. | 2020-10-01 |
| 33003177 | Given the novelty of severe acute respiratory syndrome coronavirus 2, the causative agent of the recent coronavirus disease 2019 pandemic, little is known about the pathophysiology and phenotypic expressions of this new infectious disease nor the optimal treatment approach. […] Even though basic treatment and organ support considerations seem not to differ much from other critical illness, such as pediatric septic shock and multiple organ failure, seen in PICUs, some specific issues must be considered when caring for children with severe coronavirus disease 2019 disease. […] In this clinical guidance article, we review the current clinical knowledge of coronavirus disease 2019 disease in critically ill children and discuss some specific treatment concepts based mainly on expert opinion based on limited experience and the lack of any completed controlled trials in children at this time. | 2020-10-01 |
| 33003194 | The World Health Organization announced the most promising drugs in SOLIDARITY for the global trial, and several other drugs are under investigation through ongoing clinical trials to prove the effectiveness and safety of potential therapeutics. […] While these drugs hold promise to fight the global pandemic, healthcare providers should pay attention to AEs to maximize the treatment benefit while minimizing toxicity. | 2020-10-01 |
| 33003552 | Recently, COVID-19 has been closely related to sepsis, which suggests that most deceases in intensive care units (ICU) may be a direct consequence of SARS-CoV-2 infection-induced sepsis. | 2020-10-02 |
| 33003587 | A better understanding of the spike/ACE2 interaction is still required to design anti-SARS-CoV-2 therapeutics. […] Our findings can be of importance in the development of therapeutics that block the spike/ACE2 interaction. | 2020-10-02 |
| 33003648 | Aside from the highly infectious nature of SARS-CoV-2, the lack of a treatment or vaccine has been the main reason for its spread. […] The patients’ nutritional status with COVID-19 must be analyzed before administering any treatment, and nutritional supplements should be given to the affected individuals along with routine treatment. | 2020-10-02 |
| 33003964 | Of these patients, hydroxychloroquine ± azithromycin were discontinued in 58 patients (86.6%), while one or more doses of therapy were held in the remaining nine (13.4%). […] Conclusions - The risk of torsade de pointes is low in hospitalized COVID-19 patients receiving hydroxychloroquine ± azithromycin therapy. | 2020-10-02 |
| 33003988 | Pigs are therefore unlikely to be significant carriers of SARS-CoV-2 and are not a suitable pre-clinical animal model to study SARS-CoV-2 pathogenesis or efficacy of respective vaccines or therapeutics. | 2020-10-02 |
| 33004002 | Preliminary reports suggest a high incidence of infection and mortality with SARS-CoV-2 in patients receiving kidney replacement therapy (KRT). | 2020-10-02 |
| 33004102 | Strengthening health systems and maintaining essential service delivery during health emergencies response is critical for early detection and diagnosis, prompt treatment, and effective control of pandemics, including the novel coronavirus disease (COVID-19). | 2020-10-02 |
| 33004164 | Although pain treatment has been described as a fundamental human right, the Coronavirus disease 2019 (COVID-19) pandemic forced healthcare systems worldwide to redistribute healthcare resources toward intensive care units and other COVID-19 dedicated sites. […] Therefore, the aim of this review is to analyze the impact of COVID-19 pandemic on chronic pain treatment and to address what types of strategies can be implemented or supported in order to overcome imposed limitations in delivery of chronic pain patient care. | 2020-10-02 |
| 33004167 | Appreciation for these different phases and treatment modalities, including manipulation of ventilatory settings and therapeutics, has made it a less lethal disease than when it emerged earlier this year. | 2020-10-02 |
| 33004295 | Fecal microbiota transplantation (FMT) can be a life-saving treatment against recurrent Clostridioides difficile infection (CDI). | 2020-10-02 |
| 33004529 | There are no effective treatments for the management of severe COVID-19 and current therapeutic trials are focused on antiviral therapy and attenuation of hyper-inflammation with anti-cytokine therapy. […] In the past two decades, evidence from preclinical studies has led to the emergence of potential anticoagulant therapeutic strategies for the treatment of patients with pneumonia, sepsis and acute respiratory distress syndrome, and some of these anticoagulant approaches have been trialled in humans. […] Here, we review the evidence from preclinical studies and clinical trials of anticoagulant treatment strategies in bacterial pneumonia and sepsis, and discuss the importance of these findings in the context of COVID-19. | 2020-10-02 |
| 33004712 | Ozone therapy consists in the administration of a mixture of ozone and oxygen, called medical ozone, which has been used for over a century as an unconventional medicine practice for several diseases. […] Ozone-therapy could be considered a feasible, cost-effective and easy to administer adjuvant therapy while waiting for the synthesis of a therapy or the development of the vaccine. | 2020-10-02 |
| 33004837 | Progeny virus titers of single-dose treatment of DIG, OUA and remdesivir were approximately 103-, 104- and 103-fold lower (> 99% inhibition), respectively, than that of non-treated control or chloroquine at 48 h post-infection (hpi). […] Furthermore, therapeutic treatment with DIG and OUA inhibited over 99% of SARS-CoV-2 replication, leading to viral inhibition at the post entry stage of the viral life cycle. […] Collectively, these results suggest that DIG and OUA may be an alternative treatment for COVID-19, with potential additional therapeutic effects for patients with cardiovascular disease. | 2020-10-02 |
| 33005158 | Items inquired in the survey included type and setting (home or day care center) of rehabilitation services (physical/occupational/cognitive rehabilitation) and change in psychotropic medication and in behavioral symptoms that subjects with dementia experienced before and during the epidemic. | 2020-10-02 |
| 33005276 | The proportion of patients received antiviral therapy was 45.5% in the asymptomatic group and 97.9% in the symptomatic group (p < 0.001). […] The proportion of patients received oxygen therapy was 22.7% in the asymptomatic group and 99.1% in symptomatic patients (p < 0.001). | 2020-10-02 |
| 33005417 | Asymptomatic patients may transmit SARS-CoV-2, highlighting the importance of early diagnosis and treatment. | 2020-10-02 |
| 33005428 | The efficacy of steroid treatment for coronavirus disease (COVID-19) is unknown. […] On day 20 of admission, we started to use i.v. steroid therapy. | 2020-10-02 |
| 33005516 | We also discuss the complexity of making anticoagulation treatment decision in COVID-19 patients in the absence of evidence-based guidelines. | 2020-10-02 |
| 33005518 | Phosphorus levels remained elevated, and sevelamer was added on discharge after he was weaned off oxygen and cleared by physical therapy. | 2020-10-02 |
| 33005531 | Further exploration into the impact of sex on this pandemic is required in order to develop targeted therapies, as well as public health policies, and to prevent sex bias in treatment. | 2020-10-02 |
| 33005550 | This diagnosis had implications for the treatment of her cancer, and a number of important decisions had to be made. | 2020-10-02 |
| 33005928 | The medical treatment facilities (MTF) represent the equivalent of the healthcare system in the home countries, but they face the limitations of an outpost at the end of the supply chain. […] The capabilities are limited, and the necessary effort to extend the treatment capacity is tremendous. […] To prepare our own health system within the Resolute Support mission, an interdisciplinary team of consultants and nurses located at the multinational role 2E, Camp Marmal, Mazar-e-Sharif, Afghanistan, individually reviewed medical databases and the current literature concerning triage on intensive care units. […] It is an approach that fits to the specific entities (e.g., limited medical resources in the whole system, limited intensive care unit capabilities for long-term stay or organ replacement therapy, etc.) that determine the framework of the special military health system abroad. | 2020-10-02 |
| 33006070 | The immunosuppressed status of some cancer patients increases their risk of infection compared with the general population, and cancer treatment within 2 weeks of COVID-19 diagnosis was reported as a risk factor for developing severe events. […] Palliative care workers have an essential role in the response to COVID-19 by responding rapidly and flexibly; ensuring protocols for symptom management are available, considering redeploying staffs and volunteers to provide psychosocial and bereavement care and using technology to communicate with patients and carers. | 2020-10-02 |
| 33006071 | While still maintaining a fully functioning operating theater, discrete teams were deployed to both COVID-19 and non-COVID-19 intensive care units, rapid response/airway management team, the difficult airway response team, and labor and delivery. | 2020-10-02 |
| 33006138 | Remdesivir is a direct-acting nucleoside RNA polymerase inhibitor with activity against the novel SARS-CoV-2 virus used in the treatment of COVID-19 pneumonia. […] Both patients had significant increases in transaminases between day 3 and day 10 of remdesivir therapy accompanied by coagulopathy and encephalopathy. | 2020-10-02 |
| 33006163 | Fibrinolytic therapy has also been used in patients with acute respiratory distress syndrome. […] A literature search was performed to provide the most up-to-date information on the pathophysiology, coagulopathy, risk of VTE, and prevention and treatment of VTE in patients with COVID-19. […] Although a number of international organizations have produced guideline or consensus statements, they do not all cover the same issues regarding anticoagulant therapy for patients with COVID-19, and they do not all agree. […] These statements and the most recent literature are combined into a list of clinical considerations that clinicians can use for the prevention and treatment of VTE in patients with COVID-19. | 2020-10-02 |
| 33006442 | Patients were grouped according to their BP during hospitalization and records of medication application. […] Particularly, hypertension patients receiving RAAS inhibitor treatment either before (HR = 0.35, 95%CI 0.13-0.97, P = .043) or after (HR = 0.18, 95%CI 0.04-0.86, P = .031) admission showed a significantly lower risk of adverse clinical outcomes than those receiving application of other antihypertensive medicines. | 2020-10-02 |
| 33006492 | Owing to the COVID-19 outbreak, there is an urgent need for developing and implementing alternative treatment options for IPV victims (such as online and phone counseling and telemedicine), as well as training programs for health care professionals, especially those employed in emergency departments, to facilitate early detection of IPV. | 2020-10-02 |
| 33006622 | New medication visits in Q2 of 2020 decreased by 26.0% (14.1 million visits) from Q2 2018-2019 levels. | 2020-10-02 |
| 33006644 | The study aims to investigate the effects of COVID-19 infection with asymptomatic and mild symptoms on trans-myocardial repolarization parameters in children without treatment. | 2020-10-02 |
| 33006676 | Our aim was to prospectively assess patient satisfaction about doctor-patient interaction in a high-volume radiation therapy and oncology center during the COVID-19 pandemic. […] Cancer patients receiving either systemic and/or radiation treatment underwent a survey. […] Most (89.6%) rated their treatment good, very good, or excellent. | 2020-10-02 |
| 33006811 | The results showed: 1) the number of DBS telemedicine sessions requested and the number of patients examined increased during the COVID-19 outbreak in February and March 2020 when compared with the monthly numbers in 2019; 2) the most common reason for the patients’ health service requests was poor symptom control; 3) the most common DBS tele-programming adjustment made was voltage change; 4) overall, most (89%) DBS tele-programming adjustment sessions were experienced by the patients as satisfactory; and 5) significant adverse events and unexpected treatment interruptions caused by connection failure or other hardware- or software-related problems did not occur. […] DBS telemedicine could have a unique role to play in maintaining the delivery of DBS treatment and medical care to outpatients with movement disorders during the COVID-19 pandemic. | 2020-10-02 |
| 33006936 | In the central and south Texas regions where we practice, we suspect that patient admission, treatment, and discharge volumes for acute stroke treatment have decreased significantly since COVID-19-related shelter-at-home orders were issued. | 2020-10-02 |
| 33006937 | Of the 13,937,906 examined tweets, 2,858,316 (20.51%) were about the impact of COVID-19 on the economy and markets, followed by spread and growth in cases (2,154,065, 15.45%), treatment and recovery (1,831,339, 13.14%), impact on the health care sector (1,588,499, 11.40%), and governments response (1,559,591, 11.19%). […] In contrast, we saw a reversal of sentiments from negative to positive for prevention, impact on the economy and markets, government response, impact on the health care industry, and treatment and recovery. | 2020-10-02 |
| 33006944 | Effective contact tracing is labor- and time-intensive during the coronavirus disease 2019 (COVID-19) pandemic, but essential in the absence of effective treatment and vaccines. | 2020-10-02 |
| 33006999 | The drug combination of pirfenidone and melatonin has been identified as a candidate treatment that may contribute to reduce the virus infection. | 2020-10-02 |
| 33007039 | Hydroxychloroquine (HCQ) is widely used in the treatment of malaria, rheumatologic disease such as lupus, and most recently, COVID-19. | 2020-10-02 |
| 33007149 | This virtual facilitated learning collaborative in Written Exposure Therapy, an evidence-based treatment for posttraumatic stress disorder, included virtual workshop training, phone-based clinical consultation, implementation-focused video calls for program leadership, and program evaluation. | 2020-10-02 |
| 33007195 | Here we summarize recent advances on the definitions, diagnosis, and treatment in the clinical practice of sepsis management in the emergency department. | 2020-10-02 |
| 33007239 | Cleavage and the syncytium are abolished by treatment with the furin inhibitors decanoyl-RVKR-chloromethylketone (CMK) and naphthofluorescein, but not by the transmembrane protease serine 2 (TMPRSS2) inhibitor camostat. […] Therefore, furin inhibitors may be promising antiviral agents for prevention and treatment of SARS-CoV-2 infection. | 2020-10-02 |
| 33007342 | The significance of microbiome-mediated interventions in the treatment of viral infections is also discussed. | 2020-10-02 |
| 33007369 | Early identification of rising state and multilevel course of treatment is imperative. […] The most widely used molecule for systemic treatment remains tocilizumab. […] Except for anti IL-6 treatment, contemporary research opens the possibilities for combination of pharmaceutical, non-pharmaceutical and adjunctive treatment in a successful fight with consequences of cytokine storm. | 2020-10-02 |
| 33007398 | Accordingly, we reviewed the most critical findings related to the genetics of the SARS-CoV-2, with a specific focus on genetic diversity and reported mutations, molecular-based diagnosis assays, using interfering RNA technology for the treatment of patients, and genetic-related vaccination strategies. | 2020-10-02 |
| 33007400 | To date, no anti-viral therapy has proven its efficacy considering randomized trials. | 2020-10-02 |
| 33007416 | With increasing in-depth studies of ALI/ARDS, significant breakthroughs have been made, however, there are still no effective pharmacological therapies for treatment of ALI/ARDS. […] Therefore, developing new drugs for therapy of ALI/ARDS is in great demand, which might also be helpful for treatment of COVID-19. | 2020-10-02 |
| 33007454 | Hospitals were given the opportunity to decide independently on the use of three different COVID-19 treatment strategies: HCQ or CQ, or no treatment. […] The analysis contained 1064 patients from 14 hospitals: 566 patients received treatment with either HCQ (n = 189) or CQ (n = 377), and 498 patients received no treatment. | 2020-10-02 |
| 33007455 | The concept of selectively targeting COX2 and closely related cascades might be worth trying in the treatment of COVID-19 given the substantial amount of data showing that COX2, p38 MAPK, IL-1b, IL-6 and TGF-β play pivotal roles in coronavirus-related cell death, cytokine storm and pulmonary interstitial fibrosis. […] Considering the lack of definitive treatment and importance of immunomodulation in COVID-19, COX2 inhibition might be a valuable adjunct to still-evolving treatment strategies. | 2020-10-02 |
| 33007478 | Use of corticosteroids is common in the treatment of coronavirus disease 2019, but clinical effectiveness is controversial. […] We aimed to investigate the association of corticosteroids therapy with clinical outcomes of hospitalized COVID-19 patients. […] In this single-centre, retrospective cohort study, adult patients with confirmed coronavirus disease 2019 and dead or discharged between 29 December 2019 and 15 February 2020 were studied; 1:1 propensity score matchings were performed between patients with or without corticosteroid treatment. […] A multivariable COX proportional hazards model was used to estimate the association between corticosteroid treatment and in-hospital mortality by taking corticosteroids as a time-varying covariate. […] After propensity score matching analysis, no significant differences were observed in in-hospital death between patients with and without corticosteroid treatment (47/124, 37.9% vs. […] When patients received corticosteroids before they required nasal high-flow oxygen therapy or mechanical ventilation, the in-hospital death rate was lower than that in patients who were not administered corticosteroids (17/86, 19.8% vs. […] Using the Cox proportional hazards regression model accounting for time varying exposures in matched pairs, corticosteroid therapy was not associated with mortality difference (HR 0.98, 95% CI 0.93-1.03, p 0.4694). | 2020-10-02 |
| 33007504 | Despite the great effort put in the development of vaccines and specific treatments, no prophylaxis or effective therapeutics are currently available. […] Given the potential of NO as treatment for SARS-CoV-2 infection, we have evaluated the in vitro antiviral effect of NO on SARS-CoV-2 replication. | 2020-10-02 |
| 33007575 | There are no specific therapies available and investigations regarding the treatment of this disease are still lacking. | 2020-10-02 |
| 33007742 | Since many decades, heterocyclic scaffolds have been explored exhaustively for their anticancer, antimalarial, anti-inflammatory, antitubercular, antimicrobial, antidiabetic, antiviral and many more treatment capabilities. […] Therefore, through this review, we have tried to emphasize on the anticipated role of heterocyclic scaffolds in the design and discovery of the much-awaited anti-SARS CoV-2 therapy, by exploring the research articles depicting different heterocyclic moieties as targeting SARS, MERS and SARS CoV-2 coronaviruses. […] The heterocyclic motifs mentioned in the review can serve as crucial resources for the development of SARS coronaviruses treatment strategies. | 2020-10-02 |
| 33008270 | Extracorporeal membrane oxygenation (ECMO) is considered a salvage therapy in patients with acute respiratory distress syndrome (ARDS) and refractory hypoxemia (hypoxemia persisting despite lung-protective ventilation). […] Due to this exponential increase in the number of coronavirus disease (COVID19) cases particularly the ones associated with ARDS, experts are evaluating the need for ECMO in intensive care units. | 2020-10-03 |
| 33008327 | The aim of this study was to investigate the efficacy and safety of subcutaneous injection of interferon alpha-2b (IFN alpha-2b) combined with lopinavir/ritonavir (LPV/r) in the treatment of COVID-19 infection, compared with that of using LPV/r alone. […] The length of stay, the time to viral clearance and adverse reactions during hospitalization were compared between patients using oral LPV/r and combined therapy of LPV/r and subcutaneous injection of IFN alpha-2b. […] A total of 22 patients were treated with LPV/r alone and 19 with combined therapy with subcutaneous injection of IFN alpha-2b. […] Combined therapy with IFN alpha-2b also significantly reduced the duration of detectable virus in the upper respiratory tract. […] No patient in each group was transferred to intensive care unit (ICU) or died during the treatment. | 2020-10-03 |
| 33008453 | Here, we report a case of a 55-year-old female undergoing treatment for CD20+ B cell acute lymphoblastic leukemia who experienced a viral reactivation after receiving rituximab, cytarabine, and dasatinib. […] After recovery, she resumed treatment in June for her leukemia, which included rituximab, cytarabine, and dasatinib. […] Given the short time frame from leukemia treatment to PCR positivity and the low case rate in mid-June in New York City, reinfection appears to have been unlikely and SARS-CoV-2 reactivation is a possible explanation. […] This case illustrates the risks of treating recently recovered COVID-19 patients with immunosuppressive therapy, particularly lymphocyte- and antibody-depleting therapy, and raises new questions about the potential of SARS-CoV-2 reactivation. | 2020-10-03 |
| 33008479 | We aimed to test our hypothesis that additional administration of traditional Japanese (Kampo) medicine, kakkonto (kakkon-to: KT) and shosaikotokakikyosekko (sho-saiko-to-ka-kikyo-sekko: SSKKS), is more effective in relieving symptoms and preventing the onset of severe infection in mild-to-moderate COVID-19 patients compared to those treated only with conventional treatment. […] Determined unsuitable for this study by the physician INTERVENTION AND COMPARATOR: Patients in the control group will receive conventional treatment with antipyretics, painkillers, or antitussives for symptoms that occurred after they contracted the SARS-CoV-2 infection. […] Patients in the Kampo group will receive 2.5 g of KT (TJ-1@TSUMURA and Co.) and 2.5 g of SSKKS (TJ-109@TSUMURA and Co.) 3 times a day, orally, for 14 days in addition to the conventional treatment as mentioned above. […] The number of days till at least one of the symptoms (fever, cough, sputum, malaise, shortness of breath) improves in the first 14 days of treatment. […] To assess the cough, sputum, malaise, and shortness of breath, a numeric rating scale will be used to define improvement in terms of a 2-point decrease in the number of days from the start of treatment for at least 2 days. […] Open-label with no blinding NUMBERS TO BE RANDOMIZED (SAMPLE SIZE): The main research hypothesis of this study is that the combination of Kampo medicine and conventional treatment will significantly improve the patients’ symptoms (fever, fatigue, cough, sputum, and shortness of breath) during the first 14 days of treatment as compared with conventional treatment alone. | 2020-10-03 |
| 33008761 | With the absence of specific treatment/vaccines for the coronavirus COVID-19, the most appropriate approach to control this infection is to quarantine people and isolate symptomatic people and suspected or infected cases. | 2020-10-03 |
| 33008778 | To systematically review the literature about the association between systemic corticosteroid therapy (CST) and outcomes of COVID-19 patients. | 2020-10-03 |
| 33008960 | We developed a comprehensive review of the pathophysiology mechanisms of COVID-19 and of the rationale for drugs and therapeutics that have been tested in clinical trials. | 2020-10-03 |
| 33009166 | To quantify the availability of telehealth services at substance use treatment facilities in the U.S. at the beginning of the COVID-19 pandemic, and determine whether telehealth is available at facilities in counties with the greatest amount of social distancing. […] We merged county-level measures of social distancing through April 18, 2020 to detailed administrative data on substance use treatment facilities. […] We then calculated the number and share of treatment facilities that offered telehealth services by whether residents of the county social distanced or not. […] Treatment facilities in counties with a greater social distancing were less likely to possess telemedicine capability. […] Similarly, nonopioid treatment programs that offered buprenorphine or vivitrol in counties with a greater burden of COVID-19 were less likely to offer telemedicine when compared to similar facilities in counties with a lower burden of COVID-19. […] Relatively few substance use treatment facilities offered telehealth services at the onset of the COVID-19 pandemic. | 2020-10-03 |
| 33009167 | Members from the Network of Early Career Professionals working in Addiction Medicine shared their experiences of providing treatment to PWUD during the COVID-19 pandemic. […] In most countries reported here, efforts have been made to ensure continued access to services, such as mobilising opioid agonist maintenance treatment and other essential medicines to patients. | 2020-10-03 |
| 33009340 | The relationship of coagulation tests and thrombosis requires investigation to identify best diagnostic and treatment approaches. […] Further work is required to externally validate these findings and to investigate the mechanistic drivers for these relationships to identify best diagnostic and treatment approaches for these patients. | 2020-10-03 |
| 33009361 | CASE REPORT A 63-year-old woman with a past medical history of non-Hodgkin lymphoma in remission while on maintenance therapy with the anti-CD20 monoclonal antibody, obinutuzumab, tested positive for SARS-CoV-2 via nasopharyngeal reverse transcription polymerase chain reaction (RT-PCR) testing over 12 weeks and persistently tested seronegative for immunoglobulin G (IgG) antibodies using SARS-CoV-2 IgG chemiluminescent microparticle immunoassay technology. | 2020-10-03 |
| 33009366 | At the end of inpatient treatment, 4 (16.0%) COVID-19 patients were transferred to other hospitals to continue respiratory treatment after their psychiatric symptoms were controlled while the remaining 21 (84.0%) all recovered. […] The short-term prognosis of these patients is good after conventional psychotropic treatment. | 2020-10-03 |
| 33009413 | Early identification of patients at risk of progression may facilitate more individually aligned treatment plans and optimized utilization of medical resource. | 2020-10-03 |
| 33009672 | The number of working hours, the number of hours of mask daily use, simultaneous surgical and self-filtering mask use, and working in intermediate or intensive care units were independent variables significantly associated with a higher VHI-10 score. | 2020-10-03 |
| 33009729 | COVID-19 has two management paradigms- antivirals, or treatment of its complications. […] World Health Organization’s SOLIDARITY trial is a classic example of the global research protocol which can evaluate the preferred treatment to combat COVID-19 pandemic. | 2020-10-03 |
| 33009735 | Methods were based on The Novel Coronavirus Infected Pneumonia Diagnosis and Treatment Standards. […] The ecological comparison study among the three populations have proved that social distancing, quarantine, lockdown, cutting off sources of infection and transmission routes, early detection, early isolation, early treatment are all vital to control the epidemic by reducing COVID-19 confirmed cases, severe cases and the fatality rate. | 2020-10-03 |
| 33009907 | Moreover, both SARS-CoV-2 and IAV in the mucus/medium on human skin were completely inactivated within 15 s by ethanol treatment. | 2020-10-03 |
| 33009957 | In addition, we review the BPLTTC analysis on blood pressure treatment across blood pressure levels and CVD status and discuss findings from the BRACE CORONA study that examined continuing versus suspending angiotensin-converting enzyme inhibitor or angiotensin receptor blockers in patients on these antihypertensive medications who were hospitalized with COVID-19 infection. | 2020-10-03 |
| 33009966 | Recently, reports of IPA have also emerged among SARS-CoV-2 infected patients admitted to intensive care units (ICUs). […] Consequently, testing for the presence of Aspergillus in lower respiratory secretions and galactomannan in consecutive serum samples of COVID-19 patients with timely and targeted antifungal therapy based on early clinical suspicion of IPA are highly recommended. | 2020-10-03 |
| 33009982 | The race among countries and companies to develop efficacious vaccines and therapeutics for the COVID-19 is ongoing fast, with many trials underway. […] Among this, cell-based therapy is focused on moderate to severe phases of COVID-19, and there have been promising outcomes. […] Mesenchymal stem cells (MSCs) due to their pro/anti-inflammatory and immune-modulatory behavior, Natural Killer (NK) cells thanks to their capacity of lysing virus-infected cells and regulate the resulting immune response, Dendritic cells thanks to immunotherapy and cell-based vaccine engineering, SARS-CoV2-specific T cells due to stimulate and promote the immune system and MSC-derived exosomes because of cell-free therapy and beneficial manufacturing aspects, hold great promises for cell-based therapy applications for treating COVID-19 and similar viral infections. […] However, the economic situation of governments and nations, and the cost of therapeutics influence the clinical approaches to manage and exit from this pandemic. […] This summary describes cell-based clinical trials and the cost-utility aspects of cell therapy. […] Regarding the cost of cell therapy, many believe that the high cost of cell-based therapy will decrease substantially. […] Hence, there are hopes that cellular therapy can be approved soon for the treatment of viral diseases such as COVID-19. | 2020-10-03 |
| 33010246 | Indeed it was recently reported that the rate of catheter laboratory activation for ST-segment elevation myocardial infarction has decreased by 38% in the US compared to the pre-COVID-19 period,1 and there have been similar reductions in hospital presentations for other life-threatening conditions such as acute aortic dissection.6 This has been accompanied by a concurrent increase in out-of-hospital cardiac arrests7 and, amongst patients that did present to hospital with acute myocardial infarction, increased rates of delayed presentation and complications.8 While COVID-19 has a mortality of approximately 1%,9 acute myocardial infarction in the absence of contemporary treatment has a one-month mortality of up to 50%.10 As lockdown regulations begin to relax worldwide there is a significant risk of a second-wave of COVID-19, and so it is critical to re-emphasize to patients that internet searches are not an alternative to professional medical attention. | 2020-10-03 |
| 33010257 | Forty-four patients (30%) required IMV, and 58 patients (40%) received treatment with TCZ. | 2020-10-03 |
| 33010337 | The COVID-19 pandemic has had a dramatic impact on palliative care delivery and patient experiences. […] Less is known about the experiences and responses of palliative care clinicians. […] We aimed to describe the pandemic’s impact on pediatric palliative care clinicians’ personal and professional wellbeing. […] Pediatric palliative care clinicians perceive a breadth of impacts from the COVID-19 pandemic. | 2020-10-03 |
| 33010444 | The Dutch Working Party on Antibiotic Policy constituted a multidisciplinary expert committee to provide evidence-based recommendation for the use of antibacterial therapy in hospitalized adults with a respiratory infection and suspected or proven 2019 Coronavirus disease (COVID-19). […] We suggest to stop antibiotics in patients who started antibiotic treatment upon admission when representative cultures as well as urinary antigen tests show no signs of involvement of bacterial pathogens after 48 hours. […] For patients with secondary bacterial respiratory infection we recommend to follow other guideline recommendations on antibacterial treatment for patients with hospital-acquired and ventilator-associated pneumonia. […] An antibiotic treatment duration of five days in patients with COVID-19 and suspected bacterial respiratory infection is recommended upon improvement of signs, symptoms and inflammatory markers. | 2020-10-03 |
| 33010487 | The main objective is to estimate the proportion of patients with treatment modifications. […] The planned treatment, postponement, delay and organizational modifications (RCP, teleconsultations) were studied. […] One hundred and twenty-two patients (59.5%) had a treatment maintained, 72 patients (35.1%) postponed, 11 patients (5.4%) cancelled. […] Of the 56 (27.3%) chemotherapy treatment planned, 8 (14.3%) postponed and 2 (3.6%) cancelled. | 2020-10-03 |
| 33010487 | The main objective is to estimate the proportion of patients with treatment modifications. […] The planned treatment, postponement, delay and organizational modifications (RCP, teleconsultations) were studied. […] One hundred and twenty-two patients (59.5%) had a treatment maintained, 72 patients (35.1%) postponed, 11 patients (5.4%) cancelled. […] Of the 56 (27.3%) chemotherapy treatment planned, 8 (14.3%) postponed and 2 (3.6%) cancelled. | 2020-10-03 |
| 33010487 | The main objective is to estimate the proportion of patients with treatment modifications. […] The planned treatment, postponement, delay and organizational modifications (RCP, teleconsultations) were studied. […] One hundred and twenty-two patients (59.5%) had a treatment maintained, 72 patients (35.1%) postponed, 11 patients (5.4%) cancelled. […] Of the 56 (27.3%) chemotherapy treatment planned, 8 (14.3%) postponed and 2 (3.6%) cancelled. | 2020-10-03 |
| 33010487 | The main objective is to estimate the proportion of patients with treatment modifications. […] The planned treatment, postponement, delay and organizational modifications (RCP, teleconsultations) were studied. […] One hundred and twenty-two patients (59.5%) had a treatment maintained, 72 patients (35.1%) postponed, 11 patients (5.4%) cancelled. […] Of the 56 (27.3%) chemotherapy treatment planned, 8 (14.3%) postponed and 2 (3.6%) cancelled. | 2020-10-03 |
| 33010487 | The main objective is to estimate the proportion of patients with treatment modifications. […] The planned treatment, postponement, delay and organizational modifications (RCP, teleconsultations) were studied. […] One hundred and twenty-two patients (59.5%) had a treatment maintained, 72 patients (35.1%) postponed, 11 patients (5.4%) cancelled. […] Of the 56 (27.3%) chemotherapy treatment planned, 8 (14.3%) postponed and 2 (3.6%) cancelled. | 2020-10-03 |
| 33010487 | The main objective is to estimate the proportion of patients with treatment modifications. […] The planned treatment, postponement, delay and organizational modifications (RCP, teleconsultations) were studied. […] One hundred and twenty-two patients (59.5%) had a treatment maintained, 72 patients (35.1%) postponed, 11 patients (5.4%) cancelled. […] Of the 56 (27.3%) chemotherapy treatment planned, 8 (14.3%) postponed and 2 (3.6%) cancelled. | 2020-10-03 |
| 33010487 | The main objective is to estimate the proportion of patients with treatment modifications. […] The planned treatment, postponement, delay and organizational modifications (RCP, teleconsultations) were studied. […] One hundred and twenty-two patients (59.5%) had a treatment maintained, 72 patients (35.1%) postponed, 11 patients (5.4%) cancelled. […] Of the 56 (27.3%) chemotherapy treatment planned, 8 (14.3%) postponed and 2 (3.6%) cancelled. | 2020-10-03 |
| 33010487 | The main objective is to estimate the proportion of patients with treatment modifications. […] The planned treatment, postponement, delay and organizational modifications (RCP, teleconsultations) were studied. […] One hundred and twenty-two patients (59.5%) had a treatment maintained, 72 patients (35.1%) postponed, 11 patients (5.4%) cancelled. […] Of the 56 (27.3%) chemotherapy treatment planned, 8 (14.3%) postponed and 2 (3.6%) cancelled. | 2020-10-03 |
| 33010487 | The main objective is to estimate the proportion of patients with treatment modifications. […] The planned treatment, postponement, delay and organizational modifications (RCP, teleconsultations) were studied. […] One hundred and twenty-two patients (59.5%) had a treatment maintained, 72 patients (35.1%) postponed, 11 patients (5.4%) cancelled. […] Of the 56 (27.3%) chemotherapy treatment planned, 8 (14.3%) postponed and 2 (3.6%) cancelled. | 2020-10-03 |
| 33010487 | The main objective is to estimate the proportion of patients with treatment modifications. […] The planned treatment, postponement, delay and organizational modifications (RCP, teleconsultations) were studied. […] One hundred and twenty-two patients (59.5%) had a treatment maintained, 72 patients (35.1%) postponed, 11 patients (5.4%) cancelled. […] Of the 56 (27.3%) chemotherapy treatment planned, 8 (14.3%) postponed and 2 (3.6%) cancelled. | 2020-10-03 |
| 33010487 | The main objective is to estimate the proportion of patients with treatment modifications. […] The planned treatment, postponement, delay and organizational modifications (RCP, teleconsultations) were studied. […] One hundred and twenty-two patients (59.5%) had a treatment maintained, 72 patients (35.1%) postponed, 11 patients (5.4%) cancelled. […] Of the 56 (27.3%) chemotherapy treatment planned, 8 (14.3%) postponed and 2 (3.6%) cancelled. | 2020-10-03 |
| 33010487 | The main objective is to estimate the proportion of patients with treatment modifications. […] The planned treatment, postponement, delay and organizational modifications (RCP, teleconsultations) were studied. […] One hundred and twenty-two patients (59.5%) had a treatment maintained, 72 patients (35.1%) postponed, 11 patients (5.4%) cancelled. […] Of the 56 (27.3%) chemotherapy treatment planned, 8 (14.3%) postponed and 2 (3.6%) cancelled. | 2020-10-03 |
| 33010487 | The main objective is to estimate the proportion of patients with treatment modifications. […] The planned treatment, postponement, delay and organizational modifications (RCP, teleconsultations) were studied. […] One hundred and twenty-two patients (59.5%) had a treatment maintained, 72 patients (35.1%) postponed, 11 patients (5.4%) cancelled. […] Of the 56 (27.3%) chemotherapy treatment planned, 8 (14.3%) postponed and 2 (3.6%) cancelled. | 2020-10-03 |
| 33010487 | The main objective is to estimate the proportion of patients with treatment modifications. […] The planned treatment, postponement, delay and organizational modifications (RCP, teleconsultations) were studied. […] One hundred and twenty-two patients (59.5%) had a treatment maintained, 72 patients (35.1%) postponed, 11 patients (5.4%) cancelled. […] Of the 56 (27.3%) chemotherapy treatment planned, 8 (14.3%) postponed and 2 (3.6%) cancelled. | 2020-10-03 |
| 33010487 | The main objective is to estimate the proportion of patients with treatment modifications. […] The planned treatment, postponement, delay and organizational modifications (RCP, teleconsultations) were studied. […] One hundred and twenty-two patients (59.5%) had a treatment maintained, 72 patients (35.1%) postponed, 11 patients (5.4%) cancelled. […] Of the 56 (27.3%) chemotherapy treatment planned, 8 (14.3%) postponed and 2 (3.6%) cancelled. | 2020-10-03 |
| 33010487 | The main objective is to estimate the proportion of patients with treatment modifications. […] The planned treatment, postponement, delay and organizational modifications (RCP, teleconsultations) were studied. […] One hundred and twenty-two patients (59.5%) had a treatment maintained, 72 patients (35.1%) postponed, 11 patients (5.4%) cancelled. […] Of the 56 (27.3%) chemotherapy treatment planned, 8 (14.3%) postponed and 2 (3.6%) cancelled. | 2020-10-03 |
| 33010584 | Understanding the potential mechanisms is necessary to gain better insight into COVID-19 induced seizure pathogenesis and to design the correct treatment strategies to achieve appropriate treatment for seizure and epilepsy. | 2020-10-03 |
| 33010669 | In addition, Chloroquine, which was previously used for malarial and autoimmune disease, has shown efficacy in the 2019-nCoV infection treatment. | 2020-10-03 |
| 33010822 | Together, our findings provide evidence for selective SARS-CoV-2 neurotropism and support the use of hiPSC-derived brain organoids as a platform to investigate SARS-CoV-2 infection susceptibility of brain cells, mechanisms of virus-induced brain dysfunction, and treatment strategies. | 2020-10-04 |
| 33010961 | In the context of community transmission of the virus, the impact of the pandemic on health-care systems, mainly on intensive care units (ICU), was expected to be devastating. | 2020-10-04 |
| 33011038 | Oral prednisone therapy (5 mg) was initiated and the patient was discharged on a continued prednisone taper. […] WHY SHOULD AN EMERGENCY PHYSICIAN BE AWARE OF THIS?: We present a case of a 15-year-old girl who presented to the ED with MIS-C who developed coronary aneurysms despite early therapy, to increase awareness among emergency physicians of this emerging condition. | 2020-10-04 |
| 33011076 | Passive antibody therapy has been used to immunize vulnerable people against infectious agents. […] In this study, we aim to investigate the efficacy of convalescent plasma (CP) in the treatment of severe and critically ill patients diagnosed with COVID-19. […] The data of severe or critically ill COVID-19 patients who received anti-SARS-CoV-2 antibody-containing CP along with the antiviral treatment (n = 888) and an age-gender, comorbidity, and other COVID-19 treatments matched severe or critically ill COVID-19 patients at 1:1 ratio (n = 888) were analyzed retrospectively. […] CP therapy seems to be effective for a better course of COVID-19 in severe and critically ill patients. | 2020-10-04 |
| 33011243 | Despite many proposed therapies, no effective medication has yet been approved. | 2020-10-04 |
| 33011274 | Nitric oxide (NO) treatment for sepsis has shown promise in the past, but implementation is difficult due to the challenges associated with delivery and the transient nature of NO. […] NO-np treatment significantly attenuated the pro-inflammatory response by promoting M2 macrophage repolarization, which reduced the presence of pro-inflammatory cytokines in the serum and slowed vascular extravasation. […] Given that endothelial dysfunction is a common denominator in many acute inflammatory conditions, it is likely that NO enhancement strategies may be useful for the treatment of sepsis and other acute inflammatory insults that trigger severe systemic pro-inflammatory responses and often result in a cytokine storm, as seen in COVID-19. | 2020-10-04 |
| 33011308 | Simultaneously, time-sensitive care involving other clinical services, including patients requiring chemotherapy, radiation therapy and hemodialysis did not change. | 2020-10-04 |
| 33011516 | Despite an increase in LVO during the pandemic, treatment with mechanical thrombectomy has not increased. | 2020-10-04 |
| 33011680 | Mainly, what their specific concerns were, including the challenges of medication access; and about specific social factors (health literacy, poverty, food insecurity, access to telehealth video) that may be complicating the management of rheumatologic conditions during this time. 548 rheumatologists responded from 64 countries and shared concerns of food insecurity, low health literacy, poverty and factors that preclude social distancing such as working and dense housing conditions among their patients. | 2020-10-04 |
| 33011688 | During the ongoing COVID-19 pandemic, uveitis specialists may tend to reduce the ongoing systemic IMT, or prefer less aggressive treatment strategies for NIU. | 2020-10-04 |
| 33011717 | Renal replacement therapy (RRT) did not improve survival in stage III AKI. | 2020-10-04 |
| 33011959 | More than half a year have passed since the first discovery of severe acute respiratory syndrome coronavirus-2 (SARS-CoV2), no effective treatment has been established especially in intensive care unit. […] Herein, we report our experience with a 66-year-old male patient undergoing maintenance peritoneal dialysis who became critically ill with COVID-19 and underwent several extracorporeal treatment approaches including plasma exchange, direct hemoperfusion using a polymyxin B-immobilized fiber column and continuous hemodiafiltration. […] This case suggests the significance of timely initiation of extracorporeal treatment approaches in critically ill patients with COVID-19. | 2020-10-04 |
| 33011993 | We also observed that a large number of viral agents have no therapy available and the majority of those approved in the last 32 years are restricted to some groups, especially anti-HIV. | 2020-10-04 |
| 33012056 | The experience gained with these approaches and models of treatment, where remote interaction techniques play a central role, will hone the communication skills of the paediatric dentist and will retain its usefulness even at the end of the current emergency period. | 2020-10-04 |
| 33012103 | High-dose VitD supplementation, particularly for risk groups, could be recommended to achieve and maintain optimal (range 40-60 ng/ml) serum 25-hydroxy vitamin D levels (marker of VitD status) both for COVID-19 prevention and treatment. | 2020-10-04 |
| 33012152 | Due to COVID 19 pandemic, the treatment of cancer patients has become a dilemma for every oncologist. […] Strategies were taken in form of following areas were steps need to be taken to decrease risk of infection, categorise treatment on the basis of priority, radiotherapy schedules modification, academic meetings and management of COVID positive patient/personnel in Radiation Oncology department. […] Stringent long term follow up will be done for assessing the response or any unforeseen treatment related sequelae. | 2020-10-05 |
| 33012213 | Areas covered: This manuscript reviews the efforts made in the development of small molecules for the treatment of influenza virus, primarily focused on patent applications in the last 5 years. […] In this context, the discovery of arbidol and JNJ7918 against hemagglutinin, and current efforts on RNA-dependent RNA polymerase have disclosed novel opportunities for therapeutic treatment. | 2020-10-05 |
| 33012274 | We formulated recommendations for the prophylaxis and treatment of COVID-related venous thromboembolism in ambulatory and hospitalised patients, as well as recommendations for the use of antithrombotic drugs in patients with prior indication for anticoagulation who develop COVID-19. | 2020-10-05 |
| 33012349 | This will improve interpretation of biomarkers and clinical management of COVID-19 patients by facilitating a personalized medical approach to risk stratification, prevention, and treatment. | 2020-10-05 |
| 33012537 | A high dose prophylaxis with antithrombotic medication is recommended in patients affected by moderate to severe Covid-19. | 2020-10-05 |
| 33012707 | This is a report of the first three cases of endovascular aneurysm treatment that were proctored by a remote interventionalist using a novel high-resolution low-latency streaming technology. | 2020-10-05 |
| 33012721 | In particular, we focus on the electroencephalogram (EEG) findings seen in this case and the electroclinical response to antiepileptic medication. | 2020-10-05 |
| 33012834 | Imaging of the lung is absolutely necessary to obtain a diagnosis, assess the course of disease and for treatment. | 2020-10-05 |
| 33012987 | This paper introduces a multigroup COVID-19 model with immunity, in which the total population of each group is partitioned into five compartments, that is, susceptible, exposed, infective, infective in treatment and recovered compartment. | 2020-10-05 |
| 33013059 | Though a large number of treatments, including hydroxychloroquine, anti-viral, convalescent plasma etc., are being tried, as of now treatment is symptomatic only. | 2020-10-05 |
| 33013061 | We tried to develop a guideline about the modification of the treatment regimen in such conditions. | 2020-10-05 |
| 33013062 | Management of COVID-19 with AKI is primarily supportive care, and at present, there are no evidence based effective antivirals for the treatment. | 2020-10-05 |
| 33013064 | The paper is aimed to provide guidelines about the safe use of PD and treatment of complications during the COVID pandemic. | 2020-10-05 |
| 33013092 | Deidentified patient demographic data, abnormal admission laboratory and radiology findings, treatment medications received, need for mechanical ventilation, complications, and final outcome were recorded. | 2020-10-05 |
| 33013180 | Nanomaterials have wide-ranging biomedical applications in prevention, treatment and control of diseases. | 2020-10-05 |
| 33013194 | This is set against an increased demand for emergency medical services and the resulting scarcity of resources, which makes it necessary to prioritise inpatient treatment or ensure that patients are provided with appropriate outpatient care. […] In 57% of cases, mNACA II patients (outpatient treatment) were identified, in 42% of cases, mNACA III patients (inpatient treatment) were identified, and in 1% of cases, mNACA IV (imminent danger to life) patients were identified. | 2020-10-05 |
| 33013251 | Low-dose radiation therapy (LD-RT) has historically been a successful treatment for pneumonia and is clinically established as an immunomodulating therapy for inflammatory diseases. […] The ongoing COVID-19 pandemic has elicited renewed scientific interest in LD-RT and multiple small clinical trials have recently corroborated the historical LD-RT findings and demonstrated preliminary efficacy and immunomodulation for the treatment of severe COVID-19 pneumonia. […] The recent clinical trials investigating LD-RT for COVID-19 confirm initial treatment safety. […] Based on our findings we conclude that LD-RT could be an important treatment option for COVID-19 patients that are likely to progress to severity. | 2020-10-05 |
| 33013255 | In the current scenario, finding potent drug candidates for the treatment of COVID-19 has emerged as the most challenging task for clinicians and researchers worldwide. […] In particular, Sincalide and Pentagastrin can be considered potential key players for the treatment of COVID-19 disease. | 2020-10-05 |
| 33013375 | With the lack of effective therapy, chemoprevention and vaccination, focusing on the immediate repurposing of existing drugs gives hope of curbing the pandemic. […] Interestingly, montelukast, a drug usually used in asthma, may be proposed as a potential adjuvant therapy in COVID-19. | 2020-10-05 |
| 33013395 | Most of these medicines possess the pharmacological activities of anti-inflammatory, antioxidant, antiviral, and immunity-enhancement, and may be promising medicines for the treatment or adjuvant treatment of COVID-19 patients. | 2020-10-05 |
| 33013397 | This study aims to analyze the current situation and characteristics of traditional Chinese medicine for treatment of novel coronavirus pneumonia, clarify its clinical advantages and provide a reference for clinical treatment. […] Clinical randomized controlled trials, clinical control trials and case series research involving the use of Chinese medicine for novel coronavirus pneumonia treatment were selected from PubMed, Chinese Journal Service Platform of CNKI, VIP, and WanFang Data Knowledge Service Platform from the establishment of the library to 11:00 am on April 15, 2020. […] Also, high-quality randomized controlled clinical trials on the effectiveness and safety of traditional Chinese medicine in the treatment of novel coronavirus pneumonia need to carry out. | 2020-10-05 |
| 33013412 | Corticosteroid therapy was empirically used for clinical treatment in the early stage of the disease outbreak; however, data regarding its efficacy and safety are controversial. […] The aim of this study was to evaluate the efficacy and safety of corticosteroid therapy in patients with COVID-19. […] Compared with the control treatments, corticosteroid therapy was associated with clinical recovery (RR = 1.30, 95% CI [0.98, 1.72]) and a significantly shortened length of ICU hospitalization (RR = -6.50; 95% CI [-7.63 to -5.37]), but it did not affect the mortality ((RR = 1.59; 95% CI [0.69-3.66], I2 = 93.5%), utilization of mechanical ventilation (RR = 0.35; 95% CI [0.10, 1.18]), duration of symptoms (WMD = 1.69; 95% CI [-0.24 to 3.62]) or virus clearance time (RR = 1.01; 95% CI [-0.91 to 2.92], I2 = 57%) in COVID-19 patients. […] Treatment with corticosteroids in patients with COVID-19 may cause mild adverse outcomes. […] The findings of our study indicate that corticosteroid therapy is not highly effective, but it appears to improve prognosis and promote clinical recovery in patients with severe COVID-19. | 2020-10-05 |
| 33013413 | Recent studies have demonstrated that psoralen displays multiple bioactive properties, beneficial for the treatment of osteoporosis, tumors, viruses, bacteria, and inflammation. | 2020-10-05 |
| 33013603 | Healthcare workers involved in the treatment of COVID-19 are exposed to a large degree of stress and could experience secondary trauma; hence, it is essential to plan prevention strategies for future pandemic situations. | 2020-10-05 |
| 33013666 | Background: Despite being known abroad as a viable alternative to face-to-face consultation and therapy, telerehabilitation has not fully emerged in developing countries like the Philippines. […] Twelve out of 25 studies engaged patients and physicians in remote teleconsultation, teletherapy, telementoring, or telemonitoring. | 2020-10-05 |
| 33013675 | Furthermore, we analyze the mechanisms underlying such neurological sequela and discuss possible therapeutics for patients with neurological findings associated with COVID-19. | 2020-10-05 |
| 33013676 | Immunosuppressive therapy seems to be associated with better outcomes, as it might play a protective role. | 2020-10-05 |
| 33013686 | Of the 3703 COVID-19 positive patients included in present study, 251 patients (6.8%) had pre-existing hypothyroidism and received thyroid hormone therapy. | 2020-10-05 |
| 33013911 | With a developing world catastrophe, we need to examine our known therapeutic stocks, to assess suitability for prevention and/or treatment of this pro-inflammatory virus. | 2020-10-05 |
| 33014070 | For example, in acute respiratory distress syndrome (ARDS) and pneumonia patients, MSCs-Exo and MSCs provide similar healing properties and some clinical trials have used cell-based inhalation therapy which show great promise. | 2020-10-05 |
| 33014130 | However, a single treatment of CAM has no efficacy for treating MM. | 2020-10-05 |
| 33014150 | This review emphasize on the origin of the coronoviral epidemics, discussion on the structural and functional basis of SARS-CoV-2, epidemiology, pathognomonic symptoms, fatality, available rapid diagnostic methods and proposed possible treatment methods for the treatment of COVID-19. | 2020-10-05 |
| 33014275 | Limitations of the proposed therapy include the following: it is unknown if human immune and lung cell functions are enhanced by ketosis, the risk of ketoacidosis must be assessed prior to initiating treatment, and permissive dietary fat and carbohydrate levels for exogenous ketones to boost immune function are not yet established. | 2020-10-05 |
| 33014364 | A possible solution is convalescent blood products (CBP), primarily convalescent plasma (CP) and immunoglobulins, as an adjunctive therapy. | 2020-10-05 |
| 33014379 | These fluctuations have been tentatively related to communications, publications or leaks about Remdesivir or hydroxychloroquine/azithromicin treatment. | 2020-10-05 |
| 33014462 | The aim of this study was to explore if the COVID-19-induced lung cell damage was mirrored by an arterial lactatemia higher than the central venous one; then if the administration of anti-inflammatory therapy (i.e., canakinumab 300 mg subcutaneous) could normalize such abnormal lactate a-cv difference. | 2020-10-05 |
| 33014499 | Treatment provided to the child included intranasal oxygen, antibiotics, and a dietary program with therapeutic milk. | 2020-10-05 |
| 33014523 | Multivariate logistic regression analysis indicated that older age (odds ratio [OR], 1.04; 95% confidence interval [CI], 1.02-1.06), hypertension without receiving angiotensinogen converting enzyme inhibitors or angiotensin receptor blockers (ACEI/ARB) therapy (OR, 2.29; 95% CI, 1.14-4.59), and chronic obstructive pulmonary disease (OR, 7.55; 95% CI, 2.44-23.39) were independent risk factors for progression to severe or critical pneumonia. […] Hypertensive patients without receiving ACEI/ARB therapy showed higher lactate dehydrogenase levels and computed tomography (CT) lung scores at about 3 days after admission than those on ACEI/ARB therapy. […] Multivariate Cox regression analysis revealed that male gender (hazard ratio [HR], 1.22; 95% CI, 1.02-1.46), receiving lopinavir/ritonavir treatment within 7 days from illness onset (HR, 0.75; 95% CI, 0.63-0.90), and receiving systemic glucocorticoid therapy (HR, 1.79; 95% CI, 1.46-2.21) were independent factors associated with prolonged viral shedding. | 2020-10-05 |
| 33014531 | Among various treatment options, mesenchymal stem cell-based cellular therapies are being investigated, because of their regeneration ability and multipotency along with other features like immunomodulation, antifibrosis and anti-inflammatory effects. […] This paper intends to analyze the current clinical trials on stem cell treatment of novel virus, searching and reviewing the available information and the International Clinical Trials Registry Platform (ICTRP) of World Health Organization (WHO). […] We concluded that the stem cell treatment of COVID-19 is found promising with pilot studies’ results, but still in the early development phase. | 2020-10-05 |
| 33014532 | Additionally, recent studies reported improved respiratory activity after intravenous administration of MSCs into patients affected by coronavirus disease 2019 (COVID-19) caused by the Coronavirus 2 (SARS-CoV-2) suggesting their role as anti-viral therapy. […] The high secretory activity, the immune-modulatory effect, and the homing ability make MSCs and in particular AD-MSCs both a potential tool for the anti-viral drug-delivery in the virus microenvironment and potential cellular therapy. […] In this literature review, the role of regenerative strategies through MSCs, AD-MSCs, and adipocyte-secreted exosomal microRNAs (A-SE-miRs) as a potential antiviral therapy was reported, comparing the results found with current research progress on drugs and vaccines in COVID-19 disease. | 2020-10-05 |
| 33014645 | Final year students had already been working in hospitals since before the outbreak, with 35.0% of them assisting doctors in the treatment of COVID-19 positive patients during their placements. | 2020-10-05 |
| 33014718 | Isolated operating rooms, pediatric intensive care units, and surgical wards should be specifically designed for suspected or confirmed COVID-19 cases. | 2020-10-05 |
| 33014780 | Then, after gene expression profiling experiments, we found that several “antiviral” genes, such as CD28 and IFN gamma, were upregulated, while genes with “proviral” action, such as ARG-1, CEACAM1, and FUT4, were less expressed during treatment with imatinib, thus demonstrating that TKIs are not detrimental from the immunological point of view. | 2020-10-05 |
| 33014800 | Social media were the second most common source of knowledge (43.8%) with a predilection in younger patients, nonsmokers, targeted therapy- or immunotherapy-treated patients, and breast cancer patients (>65 vs. <65 years of age, p = 0.057; nonsmoker vs. ever-smoker, p = 0.036; targeted therapy and immunotherapy vs. chemotherapy, p = 0.004; breast cancer vs. other cancers, p = 0.019). | 2020-10-05 |
| 33014801 | The consensus highlighted a multidisciplinary team diagnostic model with assessment of the balance between risks and benefits prior to treatment, individualizing satisfaction of patients’ medical needs, and acceptability in ethics and patients’ socio-economic conditions. | 2020-10-05 |
| 33014804 | The extent of COVID-19 pneumonia was correlated with inpatient management (p = 0.003) and oxygen therapy requirements (p < 0.001). […] No differences were found regarding the histology of cancer, cancer stage, metastases sites, or type of oncologic treatment between the survivor and non-survivor groups. | 2020-10-05 |
| 33014984 | In this study, we aimed to review the instructions published either before or after COVID-19’s transmission to Iran to depict the clinical approach and therapeutics used in Iran to battle the current pandemic. | 2020-10-05 |
| 33015108 | Eighteen (48.6%) patients were treated with high-flow ventilation, 9 (13.8%) with non-invasive ventilation, 10 (15.4%) with invasive mechanical ventilation, 7 (18.9%) with prone position ventilation, 6 (16.2%) with extracorporeal membrane oxygenation (ECMO), and 3 (8.1%) with renal replacement therapy. | 2020-10-05 |
| 33015109 | Since the earliest stages of this major pandemic, academics have done a huge amount of research in order to understand the disease, develop medication, vaccines and tests, and model its spread. | 2020-10-05 |
| 33015111 | Therefore, future policies in Romania should focus on shielding people in the high-risk group and prioritizing them for vaccination, whilst encouraging those in the low risk group to continue seeking treatment for their underlying diseases. | 2020-10-05 |
| 33015160 | A total of 33 mild COVID-19 cases were divided into two treatment groups (with and without glucocorticoids, methylprednisolone, were used in this setting), and the absolute value of peripheral blood lymphocyte count; CD3+, CD4+, and CD8+ T cell counts; and the time to achieve negative transformation of a nucleic acid pharyngeal swab were recorded. […] Peripheral blood lymphocyte and T cell counts were compared between the treatment group and 25 healthy individuals. […] At the point of time when there was a 50% accumulation conversion rate (positive to negative nucleic acid on pharyngeal swab), and the nucleic acid turned negative in half of the patients in two groups, the peripheral blood lymphocyte and T cell counts were compared between treatment groups. | 2020-10-05 |
| 33015366 | Growing concerns over ethical issues in mentoring in medicine and surgery have hindered efforts to reinitiate mentoring for Palliative Care (PC) physicians following the easing of COVID-19 restrictions. | 2020-10-05 |
| 33015369 | Group B had significantly higher rates of thrombotic complications and required more admissions in intensive care units. | 2020-10-05 |
| 33015402 | The development of effective mitigation strategies, therapeutics and vaccines relies on detailed genomic and biological characterization of the regional viruses. | 2020-10-05 |
| 33015537 | It involves adequate sleep hygiene, timed light exposure, and the use of a chronobiotic medication like melatonin, which affects the output phase of circadian rhythms thus controlling the biological clock. | 2020-10-05 |
| 33015546 | The pandemic of coronavirus infection 2019 (COVID-19) due to the serious respiratory condition created by the coronavirus 2 (SARS-CoV-2) presents a challenge to recognize effective strategies for management and treatment. […] The most encouraging treatment to date is suggested to be with the help of remdesivir, hydroxychloroquine, and many such repurposed drugs. […] This review presents a concise precise of the targets and broad treatment strategies for the benefit of researchers. | 2020-10-05 |
| 33015547 | He was successfully treated with a combination of milieu treatment, pharmacotherapy, and electroconvulsive therapy. | 2020-10-05 |
| 33015550 | Although, some antivirals may inhibit the virus-mediated pathogenesis and prove to be suitable in COVID-19 treatment. | 2020-10-05 |
| 33015555 | Thus, it is prudent to establish common guidelines for the monitoring and treatment of cancer patients. | 2020-10-05 |
| 33015558 | When the pandemic decreases and disappears, many obesity patients will seek treatment for obesity and the workload of surgeons will increase. […] Before bariatric and metabolic surgery operations, which is the most effective treatment of obesity and related comorbidities, necessary precautions must be determined and implemented to protect patients and healthcare workers before and during surgery. | 2020-10-05 |
| 33015559 | Many surgeons take part in the treatment of COVID-19. | 2020-10-05 |
| 33015560 | One of the major concerns is the tendency for delayed surgical treatment of breast cancer patients. […] There was a general consensus for administering neoadjuvant systemic therapy in patients with node-negative, small-size triple negative, HER2-positive and luminal A-like tumors until conditions are improved for due surgical treatment. […] Panelists also reached a consensus to extend the systemic treatment for patients with HER2-positive and luminal B-like tumors who had clinical complete response after neoadjuvant systemic therapy. | 2020-10-05 |
| 33015628 | Health practitioners all over the world are treating patients with currently available antiviral drugs, primarily the protease inhibitors used for HIV treatment. | 2020-10-05 |
| 33015631 | We present a patient with severe COVID-19 pneumonitis; poor respiratory compliance; dangerously high ventilator pressures; and hypercapnia refractory to conventional treatment including low tidal volume ventilation, neuromuscular blockade and prone position ventilation. […] Extracorporeal carbon dioxide removal was used as a rescue therapy to facilitate safer ventilator pressures and arterial partial pressures of carbon dioxide. […] After 6 days of treatment, the patient had improved to the extent that the extracorporeal support was able to be weaned and the patient was decannulated from the device. […] Following a prolonged respiratory wean, the patient was subsequently discharged from the intensive care unit and then from the hospital to home with no adverse events related to the therapy. | 2020-10-05 |
| 33015643 | Mortality at 28 days and treatment-emergent and serious adverse events were key secondary outcomes. […] The primary analysis was done in the intention-to-treat population and safety analyses were done in all patients according to treatment received. […] Analyses of the least squares mean relative change in PaO2/FiO2 at day 5 showed no differences between treatment groups (17% change in the IFX-1 group vs 41% in the control group; difference -24% [95% CI -58 to 9], p=0·15. […] The frequency of serious adverse events were similar between groups (nine [60%] in the IFX-1 group vs seven [47%] in the control group) and no deaths were considered related to treatment assignment. | 2020-10-05 |
| 33015653 | This suggests a maladaptive immune response and substantiates the evidence for immunomodulation as a target in the treatment of severe COVID-19. | 2020-10-05 |
| 33015681 | It is important that GPs: 1) have a high index of suspicion that patients with apparently typical viral conjunctivitis may have an uncommon presentation of COVID-19 illness, 2) develop appropriate telephone triage systems to reduce patient consultations, and 3) foster relationships with their ophthalmologist and optometrist colleagues who can provide phone advice, guidance on treatment initiation and definitive care when necessary. | 2020-10-05 |
| 33015815 | Data on demographics, clinical presentation at admission, co-morbidities, pharmacological treatment, admission to intensive care and death was recorded. | 2020-10-05 |
| 33015818 | Currently, there is still no definite and efficacious therapy for SARS-CoV-2 infection. […] Although, actually, the interest in a possible use for vitamin supplementation in SARS-CoV-2 patients is essentially based on indirect data, we tried to examine the evidence about a favorable effect of vitamin supplementation in the therapy of the infection and its complications. | 2020-10-05 |
| 33015819 | A literature review was conducted to identify potential drug interactions between remdesivir (used in the treatment of COVID-19) and drugs prescribed in dentistry. | 2020-10-05 |
| 33015821 | Rapid intervention, treatment, and intensive care support are essential for infected pregnant. | 2020-10-05 |
| 33015823 | We aim to describe the characteristics, screening methods, and outcomes of cancer patients with asymptomatic COVID-19 infection and to further explore anti-tumour treatment for this population. […] We collected demographic data, laboratory findings, treatment information, nucleic acid and serum test results, chest computed tomography (CT) information and survival status of cancer patients diagnosed with asymptomatic COVID-19 infection. […] Three (18.3%) patients died, and the cause of death was considered malignancy caused by delaying anti-tumour treatment. […] Unless the tumour is life-threatening or rapidly progressing, we advise restarting active anti-tumour therapy after PCR tests become negative. | 2020-10-05 |
| 33015824 | Migrant and homeless centers have a central role, as they provide a significant contribution to prevent infection spread and favor access to early medical treatment to those affected, thus preventing more severe forms of infection. | 2020-10-05 |
| 33015929 | Dental students like all other dental clinical personnel are considered to be at the highest risk amongst healthcare workers due to the nature of treatment, namely, working in the oral cavity (known reservoir for the virus) and the routine use of aerosol-generating procedures. | 2020-10-05 |
| 33015938 | By repurposing of broadly active antiviral drugs and compounds that are known to inhibit viral replication of related viruses several advances could be made in the development of treatment strategies against COVID-19. | 2020-10-05 |
| 33015942 | We review treatment in these patients, as well as our measures to reduce transmission among our hemodialysis patients and staff. | 2020-10-05 |
| 33016027 | This definitely nurtures hope for a new effective therapeutic treatment. […] We firmly believe that blocking IL-1 with an anti-inflammatory cytokine such as IL-37 and/or IL-1Ra is an effective valid therapy in a wide spectrum of inflammatory disorders including SARS-CoV-2-induced COVID-19. […] Here, we propose for the first time that IL-37, by blocking IL-1, may have an important role in the therapy of COVID-19. | 2020-10-05 |
| 33016180 | As the COVID-19 pandemic swept through the United States, our heath-system mobilized clinical pharmacy services to address critical clinical medication management needs. […] Reinforcing recommended medication management strategies for clinical pharmacists was key to successful implementation. […] Best practice strategies include converting patients from intravenous (IV) to oral medication, transitioning to IV push medication administration, evaluating standard medication administration timing, reviewing metered dose inhaler (MDI) and nebulizer utilization, using alternatives for medications in short supply, reviewing coronavirus disease COVID-19 treatment recommendations, reviewing COVID-19 patient care on interdisciplinary rounds, de-prescribing and de-escalating to eliminate unnecessary medications, and assessing for appropriate venous thromboembolism prophylaxis. […] These strategies served to help protect medication supply, reduce number of staff entries into patient rooms to conserve personal protective equipment, limit nursing time in patient rooms to reduce COVID-19 exposure risk, and to conserve compounding supplies. […] Here we present example medication management guidance as used by a large healthcare system during the COVID-19 pandemic. | 2020-10-05 |
| 33016237 | Our studies provided the foundation to further test and repurpose these candidate drugs experimentally and/or clinically for COVID-19 treatment. | 2020-10-05 |
| 33016678 | From this point of view, it is worth further studying the treatment of patients with COVID-19 with dipyridamole, which, with its antiviral activity and anti-inflammatory effect, inhibiting acute inflammation and progressive fibrosis, is the drug of choice, especially for patients with early signs of elevated D-dimer concentrations and pronounced clinical symptoms of microangiopathy. | 2020-10-05 |
| 33016683 | We retrospectively evaluated the admission and treatment data to observe the epidemiological evolution of paediatric trauma during the lockdown ordinance and compared them with the same period in 2019. | 2020-10-05 |
| 33016788 | Finally, the paper emphasizes Viktor Frankl’s cure and Wong’s integrative meaning therapy. […] It concludes that integrative meaning therapy represents the future of psychotherapy, because it is situated in the area of interactions of at least three traditions: Clinical psychology, existential psychology, and positive psychology. […] This integrative model is holistic, recognising humans as bio-psycho-social-spiritual beings and considers several theoretical perspectives in both diagnosis and treatment. | 2020-10-05 |
| 33016885 | However, only a small percentage of AYAs with OUD ever receive treatment. […] Further, among those that do receive treatment, a substantial proportion of patients continue to struggle with OUD, and many prematurely drop out of treatment. […] These challenges have only been heightened in the face of the COVID-19 pandemic, but greater utilization of telehealth and mobile technologies by OUD patients may help counter these barriers, which ultimately may improve AYA OUD treatment in the postpandemic period. […] Their perspectives may provide insights to help counter COVID-19-related consequences and offer clues to improving AYA OUD treatment in the long term. | 2020-10-05 |
| 33017071 | Previous animal studies have demonstrated an increased ACE2 expression following treatment with either angiotensin-converting enzyme inhibitors (ACEi) or angiotensin II receptor blockers (ARB) that have led to a massive precariousness regarding the optimal cardiovascular therapy during this pandemic. […] Treatment with ACEi/ARB is independently associated with an increased myocardial ACE2 mRNA expression in patients with coronary artery disease and in patients with end-stage heart failure. | 2020-10-05 |
| 33017280 | Since the WHO declared coronavirus disease 2019 (COVID-19) as a pandemic, huge efforts were made to understand the disease, its pathogenesis, and treatment. […] It also covers the basics about the disease immunopathogenesis, diagnosis, prognosis, and treatment options. […] Although almost every single week new clinical findings are published, which change our understanding of COVID-19, this review explores and explains the disease and the treatment options available so far. […] In summary, many therapeutic options are being investigated to treat and/or ameliorate the symptoms of COVID-19, but none is registered and no sufficient data to support immune-based therapy beyond the context of clinical trials. | 2020-10-05 |
| 33017365 | Although there are numerous trials underway, there is currently no medication known to cure the infection. […] Nonsteroidal anti-inflammatory drugs (NSAIDs) are inexpensive, widely available medications with antiviral and anti-inflammatory properties and may have utility as an adjunct therapy to improve outcomes in patients with severe COVID-19 infection. […] NSAIDs may be a useful adjunct therapy for patients with severe COVID-19 infection, but further investigation and clinical trials are necessary to ensure their safety and efficacy. | 2020-10-05 |
| 33017438 | These viral traces can be detected in the sewage entering a wastewater treatment plant (WTP). | 2020-10-05 |
| 33017461 | The guidance includes information on patient selection and informed consent, staff and patient triage and testing, adaptation of ART services, treatment planning and code of conduct. | 2020-10-05 |
| 33017480 | In both, venous thromboembolism was diagnosed in the emergency department, so they did not receive previous prophylactic therapy with low-molecular-weight heparin. | 2020-10-05 |
| 33017527 | To review the literature on the use of povidone prior to dental treatment for the reduction of viruses in the oral cavity. | 2020-10-05 |
| 33017613 | For the last two decades, researchers have placed hopes in a new era in which a combination of reperfusion and neuroprotection would revolutionize the treatment of stroke. […] We can do better for stroke treatment, especially when targeting inflammation following stroke. | 2020-10-05 |
| 33017616 | A non-toxic gravity steam reprocessing method has been developed for the reuse of N95 respirators consisting of 30 minutes of steam treatment at 121°C followed by 30 minutes of heat drying. | 2020-10-05 |
| 33017697 | The proportion of antiepileptic drugs (AEDs) treatment before admission was higher in EH group than in RE group(7/7 [100%] VS 2/10 [20%], P < 0.05). | 2020-10-05 |
| 33017762 | The use of chloroquine in the treatment of COVID-19 has received considerable attention. […] These diverse and complex findings indicate that hormetic dose responses commonly occur with chloroquine treatment with a range of biological models and endpoints. | 2020-10-05 |
| 33017826 | Peritoneal dialysis is a renal replacement therapy (RRT) and is at least as effective as other extracorporeal therapy options, with significant cost-effective advantages. | 2020-10-05 |
| 33017835 | Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) led to an extensive reorganization of the healthcare system in Italy, with significant deferment of the treatment of urology patients. […] We aimed to assess the impact of deferred treatment during the SARS-CoV-2 pandemic on the need for blood transfusions in 3 Italian urology departments. […] It is possible to speculate that this is the consequence of a delayed diagnosis and deferred treatment of acute conditions. | 2020-10-05 |
| 33017875 | No specific therapeutic agents or vaccines for COVID-19 are available, though several antiviral drugs, are under investigation as treatment agents for COVID-19. | 2020-10-05 |
| 33017904 | Further, almost all of the trials registered do not consider dosage adjustment in the elderly, a patient population most likely to require HCQ treatment. […] Here we describe an inhaled formulation of HCQ which has passed safety studies in clinical trials for the treatment of asthma and discuss how this approach may reduce side-effects and improve efficacy. | 2020-10-06 |
| 33017910 | In addition, safety and efficiency should be studied in phases I, II and II clinical protocols. | 2020-10-06 |
| 33017912 | As pandemic, COVID-19, and its consequences on the global economy, we hypothesized a new approach for the treatment of COVID-19 paints. | 2020-10-06 |
| 33017913 | As the nervous system has shown to be a strong modulator of respiratory function and the immune response, we want to highlight pathways involved in regulation of respiratory function, the neuro-immune axis as well as the rationale for a potential targeted treatment of fulminant acute respiratory distress syndrome via transcutaneous non-invasive vagal nerve stimulation in critically-ill COVID-19 patients. | 2020-10-06 |
| 33017914 | ALA treatment increases antioxidant levels and reduces oxidative stress. […] Thus, ALA may strengthen the human host defense against SARS-CoV-2 and can play a vital role in the treatment of patients with critically ill COVID-19. […] We think ALA treatment will be beneficial against COVID-19 in patients with diabetes. | 2020-10-06 |
| 33019286 | The DoMoMEA Project proposes a fully-wearable m-health solution able to administer a neurorehabilitation therapy in the patient’s home or every other place established by the patient for a rehabilitation session. | 2020-10-06 |
| 33019397 | In China and East Asia, acupuncture has been widely used to treat diverse diseases for thousands of years, as an important method of treatment now, it plays an indispensable role in the treatment of respiratory diseases in China. | 2020-10-06 |
| 33019563 | The first group included patients who needed treatment in person at the outpatients clinic, while the second group could be tele-monitored because they were able to self-administer therapy. […] Tele-monitoring of patients who are able to self-administer the IBD therapy can be an effective vicarious system as compared to the clinical evaluation in person, that could lead to important changes to avoid the overcrowding of the IBD outpatients clinic, especially during public health crises like the present pandemic. | 2020-10-06 |
| 33019592 | In elderly patients, particularly in those with pre-existing cardiovascular, metabolic, renal, and pulmonary disorders, the disease is particularly severe, causing prolonged hospitalization at intensive care units (ICU) and an increased mortality rate. | 2020-10-06 |
| 33019628 | Sera from healthcare workers affected by non-severe COVID-19 were longitudinally collected over four weeks, and compared to sera from patients hospitalized in Intensive Care Units (ICU) and SARS-CoV-2-negative subjects for the presence of IgM, IgG and IgA antibodies as well as soluble pro-inflammatory mediators in the sera. […] Non-hospitalized subjects showed lower antibody titers and blood pro-inflammatory cytokine profiles as compared to patients in Intensive Care Units (ICU), irrespective of the antibodies tested. | 2020-10-06 |
| 33019667 | Although imperfect, unique responses were developed within telemedicine platforms to mitigate disruptions broadly and effectively in care and treatment modalities. | 2020-10-06 |
| 33019676 | Patients were randomized to the eHealth treatment group, which received a tailored HRQOL report and interpretation guide, or to a wait-list control group. […] Treatment effects were measured using the standardized mean difference (SMD) in change scores between groups. […] The eHealth intervention was also assessed by a survey of the experimental treatment group 1 month following randomization. […] A total of 102 patients were randomized, including 52 in the eHealth treatment group and 50 in the wait-list control group, and 100 (98%) completed the trial. […] Although the eHealth intervention met the criteria for a small treatment effect in improving the overall SPADE cluster score (SMD = 0.24; p= 0.23) and anxiety (SMD = 0.24; p = 0.23), and for a small-to-medium treatment effect in improving depression (SMD = 0.37; p = 0.06) and back-related disability (SMD = 0.36; p = 0.07), none of these results achieved statistical significance because of limited sample size. | 2020-10-06 |
| 33019838 | At this time, there is no valid vaccine and no proven drug treatment for COVID-19 patients. […] Current treatments are focused on Oxygenation, Cytokine Storm management, anti-inflammatory effects, and antiviral therapy. […] Antiviral photodynamic therapy (aPDT) is based on the reaction between a photo-sensitive agent and a light source in the presence of oxygen which can produce oxidative and free radical agents to damage the virus’ structures. […] The aim of this study was to find out the potential therapeutic effects of Nano antiviral photodynamic therapy on COVID-19. […] This review evaluates Nano Antiviral Photodynamic Therapy: A Probable Biophysicochemical Management Modality in SARS-CoV-2. | 2020-10-06 |
| 33019877 | Of these, 167 (40%) patients needed to change their medication schedule due to this non-availability. | 2020-10-06 |
| 33019894 | On admission, fibrobronchoscopy with bronchoalveolar lavage (BAL) revealed Pneumocystis jirovecii infection so treatment with intravenous trimethoprim-sulfamethoxazole was initiated. […] Due to RP-ILD worsening, immunosuppressive therapy was intensified using methylprednisolone pulses, cyclophosphamide, tofacitinib and intravenous immunoglobulin without response. […] Despite aggressive treatment of RP-ILD due to anti-MDA5 JDM, there was no improvement of respiratory failure in the following days and patient developed refractory septic shock and died. […] For this reason, intensive immunosuppressive therapy is essential including the use of promising drugs such as tofacitinib. | 2020-10-06 |
| 33020069 | It also suggested that COVID-19 patients with a venous thromboembolic event be treated with therapeutic anticoagulant therapy for 3 months. | 2020-10-06 |
| 33020111 | Analysis of trial registration data for COVID-19 treatment studies enrolling in England showed that by 12 July 2020, 29 142 participants were needed. […] 82 (3.9%) declined participation, 699 (33.6%) were excluded on clinical grounds, 363 (17.4%) were medically fit for discharge and 153 (7.3%) were receiving palliative care. | 2020-10-06 |
| 33020224 | To monitor hospital activity for presentation, diagnosis and treatment of cardiovascular diseases during the COVID-19) pandemic to inform on indirect effects. | 2020-10-06 |
| 33020332 | One of the most used strategies that can be used to control the spread of COVID-19 is the 3T (test, trace, and treatment) strategy. | 2020-10-06 |
| 33020333 | Patients with autoimmune disease were asked about demographic characteristics, diagnosis, history of treatment, knowledge, perception, and practice regarding COVID-19. there were 685 respondents. […] Adequacy of information, autoimmune treatment, work from home, educational background, area of living, and health care facilities contributed to perception regarding COVID-19 pandemic. | 2020-10-06 |
| 33020338 | This case series emphasizes the importance of understanding this phenotype so that clinicians can provide more appropriate treatment management and also availability of CT scans in health facilities that manage COVID -19. | 2020-10-06 |
| 33020340 | To date, there is still no vaccine or specific antiviral treatment for COVID-19. […] Therefore, prevention of infection in people with cardiovascular risk and mitigation of the adverse effects of treatment is necessary. | 2020-10-06 |
| 33020343 | Identification of existing approaved therapy with proven safety profile to treat hyperinflammation is critical unmet need in order to reduce COVID-19 associated mortality. […] Preliminary studies have shown that immune-modulatory or immune suppressive treatments might be considered as treatment choices for COVID-19, particularly in severe disease. […] This article review the pathogenesis and treatment strategies of COVID-19 virus-induced inflammatory storm in attempt to provide valuable medication guidance for clinical treatment. | 2020-10-06 |
| 33020690 | Pharmacological treatments including antivirals (Lopinavir/Ritonavir), Immuno-modulatory and anti-inflammatory drugs including, Tocilizumab and Hydroxychloroquine (HCQ) has been widely investigated as a treatment for COVID-19. […] Patients were classified into two groups according to treatment type: in the HCQ group, patients were treated with HCQ; in the SC group, patients were treated with other antiviral or antibacterial treatments according to Ministry of Health (MOH) protocolsThe outcomes were hospitalization days, ICU admission, and the need for mechanical ventilation.We estimated the differences in hospital length of stay and time in the ICU between the HCQ group and the standard care (SC) group using a multivariate generalized linear regression. […] Approximately 59% (n=95) received HCQ-based treatment, and 41% (n=66) received SC. […] Length of hospital stay and time in ICU in for patients who received HCQ based treatment was shorter than those who received SC. […] Similarly, there was less need for ICU admission and mechanical ventilation among patients who received HCQ based treatment compared with SC, (8.6% vs. | 2020-10-06 |
| 33020697 | The need to hospitalize the large number of patients with severe forms of COVID-19 led the National Health System to move a large number of specialists from their disciplines to the emergency hospital departments for the treatment of COVID-19. | 2020-10-06 |
| 33020719 | The WHO and countries with severe outbreaks have developed diagnosis and treatment guidelines. […] Using the diagnosis and treatment guidelines of the WHO and the United States and China as examples, we evaluate the transformation of scientific results from basic research to applications. […] COVID-19 has fostered interdisciplinary cooperative research, and the current results are mainly focused on the origin, epidemiological characteristics, clinical research, and diagnosis and treatment methods for the virus. […] Due to the ongoing publication of new research, diagnosis and treatment guidelines are constantly improving. | 2020-10-06 |
| 33020726 | Therefore, we should develop effective and feasible measures to promote exercise and dietary therapy, especially for those who engage in teleworking. | 2020-10-06 |
| 33020729 | Adjuvant treatment with in-situ lyticase may be considered for catheter salvage therapy if the catheter could not promptly removed in time. | 2020-10-06 |
| 33020733 | We performed acute and subacute emergencies which include diagnosis and treatment of malignant tumors of the head and neck, management of airway emergencies in adults and children, drainage of abscesses of the head and neck, Foreign body removal, emergency nasal debridement and surgeries for the unsafe ear. | 2020-10-06 |
| 33020988 | COVID-19 and its control policies have already resulted in major disruptions to the screening, treatment, and surveillance of NCD patients. | 2020-10-06 |
| 33021025 | No evidence-based treatment has been approved so far.2 Outcomes of COVID-19 in Liver Transplant (LT) recipients are not well known at present. | 2020-10-06 |
| 33021051 | Despite being the gold-standard for the treatment of selected individuals with severe obesity, there is scarce information on whether or not bariatric surgery modifies the prognosis of people living with obesity in the current COVID-19 pandemic. | 2020-10-06 |
| 33021094 | Patients whose wishes are left unsaid often receive burdensome life sustain therapy by default, prolonging patient suffering. […] The CoVID pandemic has strained our healthcare resources and raised the need for prioritization of life-sustaining therapy. | 2020-10-06 |
| 33021102 | In the UK, one in two people will develop cancer during their lifetimes and radiotherapy (RT) plays a key role in effective treatment. […] High energy proton beam therapy commenced in the UK National Health Service in 2018. […] However, they also require more costly equipment including larger gantries to deliver the treatment. […] There was unanimous agreement that the UK should develop a facility for heavier charged particle therapy, perhaps constituting a new National Ion Research Centre to enable research using protons and heavier charged particles. […] Other potential collaborations might be exploited, including with space agencies, electronics and global communications industries and the nuclear industry.In preparation for clinical delivery, there may be opportunities to send patients overseas (for 12C or 4He ion therapy) using the model of the National Health Service (NHS) Proton Overseas Programme and to look at potential national clinical trials which include heavier ions, FLASH or SFRT. […] The initiative should be a community approach, involving all interested parties with a vision that combines discovery science, a translational research capability and a clinical treatment facility. | 2020-10-06 |
| 33021320 | Indications for surgery must be rigorous, balancing the advantage of early surgical treatment and risks of treatment delay. […] To decrease the occupancy rate of intensive care unit beds, elective surgical treatment should be delayed until local endemic control, according to stage of disease. | 2020-10-06 |
| 33021483 | The infection control measures became barriers for communication among patient, family, and multidisciplinary medical team about discharge planning and withdrawal of life sustaining treatments in palliative care. […] We aimed to establish the model of smartphone-enabled telehealth for palliative care family conference with integration of shared decision making concept (SDM) and VALUE (value, acknowledge, listen, understand, and elicit) approach in the face of COVID-19 threat. […] The framework of the telehealth for palliative care family conference was developed on the basis of SDM model with “team talk”, “option talk”, and “decision talk”. […] The model was implemented in a national cancer treatment center in Taiwan from February 2020. […] From February to April 2020 during COVID-19 era, 14 telehealth family conferences in the palliative care unit were analyzed. […] The model of smartphone-enabled telehealth for palliative care family conference with integration of SDM demonstrated high satisfaction of the family and was effective in reaching consensus. | 2020-10-06 |
| 33021506 | While sampling differences in sex, collection timing, bacteria/fungal infection, and corticosteroid treatment limit interpretation, we believe that reprograming monocyte or macrophages by targeting immunometabolism, epigenetics, or the cytokine milieu holds promise in resolving lung-inflammation associated with COVID-19. | 2020-10-06 |
| 33021511 | In a retrospective cohort study conducted in 347 patients hospitalized for COVID-19 (Bichat Hospital, Paris, France, 23 January-29 April 2020), RAAS blocker exposure, as well as timing and reason for treatment modifications, were collected. […] Mortality was 8% when treatment was maintained or introduced, and 12% in patients never exposed. […] A ‘healthy user-sick stopper’ bias influences RAAS blocker prescription after hospital admission for COVID-19, and explains the seemingly favourable outcome associated with in-hospital treatment. | 2020-10-06 |
| 33021704 | The coronavirus disease (COVID-19) pandemic has changed routine clinical practice worldwide with major impacts on the provision of care and treatment for stroke patients. […] Patient demographics, characteristics of the stroke, treatment details and logistics were compared with patients admitted in the corresponding weeks in the year before (2019). | 2020-10-06 |
| 33022124 | Among hypertensive patients, the association between treatment with angiotensin-converting enzyme inhibitors (ACEIs) or angiotensin II receptor blockers (ARBs) and the clinical severity of Covid-19, remains uncertain. […] To determine whether hypertensive patients hospitalized with Covid-19 are at risk of worse outcomes if on treatment with ACEIs or ARBs compared to other anti-hypertensive medications. […] We compared patients on treatment with an ACEIs/ARBs (ACEIs/ARBs group) to patients receiving other anti-hypertensive medications (No-ACEIs/ARBs group). […] After adjustment for comorbidities, age and degree of severity at the presentation, ACEIs or ARBs treatment was an independent predictor neither of in-hospital death nor of the combination of in-hospital death/need for ICU. […] No differences were documented between treatment with ACEIs compared to ARBs. […] Among hypertensive patients hospitalized for Covid-19, treatment with ACEIs or ARBs is not associated with an increased risk of in-hospital death. | 2020-10-06 |
| 33022271 | The absence of a specific treatment for SARS-CoV-2 infection led to an intense global effort in order to find new therapeutic interventions and improve patient outcomes. […] In this review, we describe the roles of 5-HT in the regulation of systemic inflammation and the potential benefits of the use of specific serotonin reuptake inhibitors as a coadjutant therapy to attenuate neurological complications of COVID-19. | 2020-10-06 |
| 33022293 | (Hydroxy)chloroquine was the most frequently evaluated treatment (n=69, 62%), before BCG vaccine (n=12, 11%), this followed by numerous antivirals and immune enhancers. | 2020-10-06 |
| 33022374 | The office of the Algerian society of transfusion and hemobiology composed of hemostasis and blood transfusion experts from Algerian hospitals on the epidemic front line have established a consensus on the issue through 4 axes: Indication of thromboprophylaxis, monitoring of hemostasis, indications of transfusion in the event of disseminated intravascular coagulation (DIC) and anticoagulant treatment after discharge. | 2020-10-06 |
| 33022712 | Thus, there is a strong rationale to target AKI for therapy in COVID-19. […] Furthermore, many approaches that have been developed for other etiologies of AKI such as sepsis, inflammation and ischemia-reperfusion, have relevance in the treatment of COVID-19 AKI and could be rapidly pivoted to this new disease. | 2020-10-06 |
| 33022728 | Decisions about the initiation, continuation and termination of life-supporting treatments are a permanent challenge in intensive care units (ICUs). […] Factors influencing the short term prognosis are mostly the severity of the acute leading disease, the number and severity of other organ failures and the response to initial treatment. | 2020-10-06 |
| 33022754 | By revisiting available treatment options, this review provides surgical oncologists with an evidence-based framework for treating patients with gastrointestinal stromal tumor, extremity/truncal soft tissue sarcoma, and retroperitoneal sarcoma to rapidly adapt their decision-making to the constant evolution of the COVID-19 pandemic. | 2020-10-06 |
| 33022856 | Fourteen of 75 asymptomatic but positively tested patients received chemotherapy or chemo-immunotherapy according to their regular therapy algorithm (±4 weeks of SARS-CoV-2 test), and 48 of 78 (61.5%) positive-tested patients received glucocorticoids as co-medication. […] None of the asymptomatic infected patients showed unexpected complications due to the SARS-CoV-2 infection during the cancer treatment. […] Moreover the relatively low appearance of symptoms due to COVID-19 among patients on chemotherapy and other immunosuppressive co-medication like glucocorticoids indicate that suppressing the response capacity of the immune system reduces disease severity. | 2020-10-06 |
| 33023033 | Plasma therapy has also been authorised for emergency use for the treatment of COVID-19 on a smaller scale. | 2020-10-07 |
| 33023039 | With no approved vaccination or treatment, governments around the world have issued guidance to their citizens to remain at home in efforts to control the spread of the disease. | 2020-10-07 |
| 33023050 | This review is intended to systematize the knowledge on the treatment of patients with congenital bleeding disorders (CBD) during the SARS-CoV-2 pandemic. […] Extensive literature research was conducted into COVID-19 and the general medical and dental treatment of patients with CBD. […] The results of this research are presented in the form of recommendations for the treatment of patients with coagulopathies. | 2020-10-07 |
| 33023326 | For these reasons, we have introduced a new treatment regimen that is aimed at reducing the number of in-person visits and achieving continuity of treatment. | 2020-10-07 |
| 33023342 | We have made great strides toward genuine multidisciplinary patient-centered care, but the continued use of telehealth and virtual visits can bring us closer to optimally arranging the spokes of the provider team members around the central hub of the patient as we progress down the road through treatment. | 2020-10-07 |
| 33023358 | Intensive worldwide efforts are underway to determine both the pathogenesis of SARS-CoV-2 infection and the immune responses in COVID-19 patients in order to develop effective therapeutics and vaccines. | 2020-10-07 |
| 33023432 | Thus far, there is no available treatment and vaccination for COVID-19. […] But the evidences for their in vivo use have not been established yet in terms of clinical effect, duration of stay in intensive care units as well as the refuge of these drugs and their combinations. | 2020-10-07 |
| 33023445 | The World Health Organisation (WHO) is steadily updating the treatment protocol for COVID-19 based on the recent clinical trials. […] The current focus should be on the development of novel proven therapeutics along with vaccines. | 2020-10-07 |
| 33023459 | In this review, some of the interesting aspects of covid-19 are discussed, that includes, the origin of the SARS-CoV-2, clinical manifestation, treatment and future aspects of the disease. | 2020-10-07 |
| 33023500 | After a Caesarean section (C-section) she developed high blood pressure, and we initiated antihypertensive treatment with labetalol, amlodipine and captopril. | 2020-10-07 |
| 33023669 | We aimed to examine whether the combination of high-flow nasal oxygen therapy (HFNO) with awake-PP prevents the need for intubation when compared to HFNO alone. […] Logistic models were fitted to predict treatment at baseline using the following variables: age, sex, obesity, non-respiratory Sequential Organ Failure Assessment score, APACHE-II, C-reactive protein, days from symptoms onset to HFNO initiation, respiratory rate, and peripheral oxyhemoglobin saturation. […] The use of awake-PP as an adjunctive therapy to HFNO did not reduce the risk of intubation [RR 0.87 (95% CI 0.53-1.43), p = 0.60]. | 2020-10-07 |
| 33023671 | Randomised, open-label, multicenter phase II trial, designed to assess the clinical outcome of SARS-CoV-2 disease in high-risk patients (group 1 to group 4) following treatment with anti-SARS-CoV-2 convalescent plasma or standard of care. […] High-risk is defined as SARS-CoV-2 positive infection with Oxygen saturation at ≤ 94% at ambient air with additional risk features as categorised in 4 groups: • Group 1, pre-existing or concurrent hematological malignancy and/or active cancer therapy (incl. chemotherapy, radiotherapy, surgery) within the last 24 months or less. […] • Viral load, changes in antibody titers and cytokine profiles are analysed in an exploratory manner using paired non-parametric tests (before - after treatment). […] After finishing all study-relevant procedures, therapy, and follow-up period, the patient is followed in terms of routine care and treated if necessary. | 2020-10-07 |
| 33023681 | Intervention trials should be conducted to assess whether vitamin K administration plays a role in the prevention and treatment of severe Covid-19. | 2020-10-07 |
| 33023821 | All patients received antiviral therapy based on ritonavir and lopinavir, associated with hydroxychloroquine. […] Despite treatment, two patients with advanced cancers died after 39 and 17 days of hospitalization, while the patient with lung cancer was dismissed at home, in good conditions. | 2020-10-07 |
| 33023853 | As a result, ten studies evaluating fresh plasma and frozen-thawed plasma treated with different PI/ PDI methods and evaluating concentrations of coagulation factors and natural anticoagulants both before and after photochemical treatment were included in the review. | 2020-10-07 |
| 33023905 | The COVID-19 pandemic has significantly reduced the incidence of MI referred for invasive treatment strategy. | 2020-10-07 |
| 33023941 | The present systematic review and meta-analysis describes the incidence of AKI, need for renal replacement therapy (RRT) and mortality among patients with COVID-19-associated AKI. | 2020-10-07 |
| 33023976 | Two papers, addressing the treatment of COVID-19, have been published in two of the most prestigious medical journals; the authors declared to have analysed electronic health records from a private corporation, which apparently collected data of tens of thousands of patients, coming from hundreds of hospitals. | 2020-10-07 |
| 33024053 | Using this E2E approach, this study showed that, in some cases, noninfectious viral fragments of SARS-CoV-2 persisted on surfaces for as long as 8 days even after bleach treatment. | 2020-10-07 |
| 33024082 | Convalescent plasma (CP) transfusion has been indicated as a promising therapy in the treatment for other emerging viral infections. […] However, the quality control of CP and individual variation in patients in different studies make it rather difficult to evaluate the efficacy and risk of CP therapy for coronavirus disease 2019 (COVID-19). […] We aimed to explore the potential efficacy of CP therapy, and to assess the possible factors associated with its efficacy. […] This study indicated that CP might be a potential therapy for severe patients with COVID-19. | 2020-10-07 |
| 33024121 | Comorbid conditions appear to be common among individuals hospitalised with coronavirus disease 2019 (COVID-19) but estimates of prevalence vary and little is known about the prior medication use of patients. […] Compared to 84,585 individuals hospitalised with influenza in 2014-19, COVID-19 patients have more typically been male, younger, and with fewer comorbidities and lower medication use. | 2020-10-07 |
| 33024307 | We summarize current knowledge of clinical, epidemiological and pathological features of COVID-19, as well as recent progress in animal models and antiviral treatment approaches for SARS-CoV-2 infection. | 2020-10-07 |
| 33024368 | JRs need to undergo further training in a few aspects of the ventilatory management, and also, they need to update themselves with newer treatment modalities as they keep evolving. | 2020-10-07 |
| 33024405 | The involvement of ZMK-with their own resources and existing infrastructural links to the hospital as a whole-could lead to faster and more effective patient treatment in the event of a pandemic or MASCAL situation. | 2020-10-07 |
| 33024459 | Moreover, it is discussed how real-world data and trials with IL-6 signaling blockade will be crucial in informing the development of new treatment for COVID-19 pneumonia. […] Given physiological roles of IL-6 in inflammatory conditions and the data from real world, IL-6 signal inhibitors, along with standard of care (SOC) treatment, might provide efficacy, offering the potential to treat COVID-19 in hospitalized populations more effectively than current SOC alone. […] Therefore, on-going and planned randomized placebo-controlled studies in combination with SOC and other therapeutics to assess safety and efficacy of IL-6 signal inhibitors in hospitalized patients with severe COVID-19 pneumonia will be warranted to address the high unmet need and burden of disease in this severely ill population. | 2020-10-07 |
| 33024515 | However, many hopes are put in developing an effective vaccine against the virus, and different therapeutic options have been implemented to find effective, even though not specific, treatment to the disease. | 2020-10-07 |
| 33024717 | The pandemic severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has garnered the attention of scientists worldwide in the search for an effective treatment while also focusing on vaccine development. […] This opinion review attempts to address three burning questions on COVID-19 treatment options. […] (1) What kind of studies are currently published or ongoing in the treatment of patients with COVID-19? […] (2) What drugs are currently described in the literature as options of treatment for patients affected by the infection? […] And (3) Are there specific clinical manifestations related to COVID-19 that can be treated with a customized and targeted therapy? […] By answering these questions, we wish to create a summary of current COVID-19 treatments and the anti-COVID-19 treatments proposed in the recent clinical trials developed in the last 3 mo, and to describe examples of clinical manifestations of the SARS-CoV-2 infection with a cause-related treatment. | 2020-10-07 |
| 33024749 | Optimal management of the Coronavirus Disease-2019 disease is evolving quickly and treatment guidelines, based on scientific evidence and experts’ opinions with clinical experience, are constantly being updated. | 2020-10-07 |
| 33025046 | Conventional asthma treatment includes inhaled corticosteroids (ICS), allergen immunotherapy (AIT), and biologics, and should be continued as they might reduce the risks of asthmatics for coronavirus infection by enhancing antiviral defence and alleviating inflammation. | 2020-10-07 |
| 33025071 | This article describes the COVID-19 psychosocial first aid concept at the University Hospital Munich (LMU Klinikum) developed by an interdisciplinary team of psychiatric, psychological, spiritual care, psycho-oncological, and palliative care specialists. | 2020-10-07 |
| 33025218 | In this paper, we will discuss the management and treatment of a novel fourth case of COVID-19-associated intussusception. | 2020-10-07 |
| 33025225 | Limited data are available regarding antiviral therapy efficacy in most severe patients under mechanical ventilation for Covid-19-related acute respiratory distress syndrome (ARDS). […] After adjustment for age, sex, BMI, chronic hypertension and chronic renal disease, the use of L/R was associated with an increased risk of renal replacement therapy (RRT). […] The use of L/R treatment was associated with an increased need for RRT. […] Take home message Neither hydroxychloroquine nor lopinavir/ritonavir as COVID-19 antiviral treatment is associated with higher ventilator-free days at day 28 when compared with standard of care (no antiviral treatment) in ICU patients under invasive mechanical ventilation. […] Lopinavir/ritonavir is associated with an increased risk of renal replacement therapy requirement. | 2020-10-07 |
| 33025304 | Eighty-eight questionnaires were included in the demographic/clinical workflow analysis, and 64 were analyzed for treatment management. | 2020-10-07 |
| 33025310 | Identification of the underlying mechanism responsible for the high thrombus burden in these patients is important as it may result in changes in their primary management strategy, either primary PCI, fibrinolytic therapy, or a pharmaco-invasive strategy. […] Furthermore, adjunctive anticoagulation and antiplatelet therapy may need to be revised. | 2020-10-07 |
| 33025384 | Care and control of all comorbidities should be one of the primary goals in patients with hypercortisolism requiring immediate and aggressive treatment. | 2020-10-07 |
| 33025463 | High-risk individuals with COVID-19 should be prioritized to target preventive strategies, including optimal antithrombotic management, medication review, and stringent monitoring. | 2020-10-07 |
| 33025516 | We collected data on patient demographics, comorbidities, chronic medications, vital signs, baseline laboratory test results and in-hospital treatment in patients with COVID-19 consecutively admitted to our Institution. […] Of these, 79 (45%) showed an acute worsening of a preexisting CKD, and 21 (12%) required kidney replacement therapy. | 2020-10-07 |
| 33025599 | In this paper, bioinformatics and network biology were used to systematically explore the mechanisms of the AR-AMR herb pairs in treatment of pneumonia, and further analyze the correlation mechanism between it and COVID-19 develop pneumonia. | 2020-10-07 |
| 33025925 | The aim of the present study was to take a survey on Italian practitioners concerning the perceived risks of aerosol contamination in COVID-19 times and their attitude toward modifications of treatment protocols to reduce this risk. | 2020-10-07 |
| 33025993 | Both theoretical and experimental efforts are seeking to find an effective treatment to suppress the virus. […] Our results suggest several promising approved and bioactive inhibitors of SARS-CoV-2 Mpro as follows: a bioactive compound, ChEMBL275592, which has the best MM/GBSA binding energy; the second-best compound, montelukast, is an approved drug used in the treatment of asthma and allergic rhinitis; the third-best compound, ChEMBL288347, is a bioactive compound. | 2020-10-07 |
| 33026199 | Patients on regular hemodialysis treatment present a high risk of infection due to the co-pathologies present, while healthcare workers may represent a risk for themselves and for the patients, due to the treatment environment and the close contact with them. | 2020-10-07 |
| 33026202 | Home therapy included lercanidipine and clonidine. […] The situation was managed first in the intensive care unit with CRRT cycles (continuous renal replacement therapy) and then in a “yellow area” devoted to COVID patients, where the patient was dialyzed by us nephrologists through short cycles of CRRT. […] Dialysis continued with high cut-off filters until the normalization of kidney function; the supportive medical therapy has also improved the course of the pathology and contributed to the favorable outcome for our patient. | 2020-10-07 |
| 33026203 | We report the case of a 93-year-old woman on haemodialysis treatment for more than 30 months and with multiple comorbidities who recovered from a Covid-19 infection without any significant clinical problems. | 2020-10-07 |
| 33026313 | An important factor permitting the treatment of patients in a prioritized fashion was our pre-existing centralized OR booking (CORB) framework, which already required surgeons to categorize the priority level for each patient. | 2020-10-07 |
| 33026344 | Another challenge for the hemostasis laboratory is the monitoring of heparin treatment. | 2020-10-07 |
| 33026419 | Positive tests within two weeks occurred in 7/5380 (0.13%) of surgical patients, 3/8506 (0.04%) of injection patients, and 6/2519 (0.24%) of energy therapy patients. | 2020-10-07 |
| 33026569 | These presumed abnormalities in hemostasis have been associated with filter clotting during continuous renal replacement therapy (CRRT). | 2020-10-07 |
| 33026622 | Quality dental treatment may not be possible without the interference of aerosols in daily dental practice. | 2020-10-07 |
| 33026628 | The need for postmortem information is urgent to improve patient management of mild and severe illness, and treatment strategies. | 2020-10-07 |
| 33026649 | However, it is unclear whether any components of autophagy, or virophagy, can be the therapeutic targets for COVID-19 treatment. […] Taken together, class III PI3-kinase may be a possible target for COVID-19 therapeutics development. | 2020-10-07 |
| 33026741 | Whether combined treatment with recombinant interferon beta-1b and lopinavir-ritonavir reduces mortality among patients hospitalized with Middle East respiratory syndrome (MERS) is unclear. […] In a prespecified subgroup analysis, treatment within 7 days after symptom onset led to lower 90-day mortality than use of placebo (relative risk, 0.19; 95% CI, 0.05 to 0.75), whereas later treatment did not. […] The effect was greatest when treatment was started within 7 days after symptom onset. | 2020-10-07 |
| 33026944 | Palliative care is a values-driven approach for providing holistic care for individuals and their families enduring serious life-limiting illness. […] The genesis of palliative care was developed through a traditional Western lens, which dictated models of interaction and communication. […] As the importance of palliative care is increasingly recognized, barriers to accessing services and perceptions of relevance and appropriateness are being given greater consideration. […] The COVID-19 pandemic and recent social justice movements in the United States, and around the world, have led to an important moment in time for the palliative care community to step back and consider opportunities for expansion and growth. […] This article reviews traditional models of palliative care delivery and outlines a modified conceptual framework to support researchers, clinicians, and staff in evaluating priorities for ensuring individualized patient needs are addressed from a position of equity, to create an actionable path forward. | 2020-10-07 |
| 33027056 | Group pain management programmes are a core treatment provided by many pain services. | 2020-10-07 |
| 33027152 | Lessons learned include: the need to develop and deploy valid tests for point-of-care diagnosis and surveillance; the importance of considering HIV and COVID-19 in the context of syndemics; the potential role of structural interventions that address drivers of disparities; how existing research infrastructure can be leveraged to accelerate development of therapeutics and vaccines; and how modeling that is tailored to regional epidemics can inform policy. | 2020-10-07 |
| 33027185 | Important questions remain unanswered regarding why children have mild disease compared with adults; how children of different ages contribute to asymptomatic community transmission of the virus; and the pathophysiology of and most appropriate investigation and treatment strategies for the novel hyperinflammatory syndrome. | 2020-10-07 |
| 33027192 | The incidence of pulmonary embolism, deep venous thrombosis, major bleeding (MB), clinically relevant non-MB, acute respiratory distress syndrome, and in-hospital mortality was compared between patients on fondaparinux versus enoxaparin therapy. | 2020-10-07 |
| 33027281 | Given that there is no effective treatment or vaccine for COVID-19, it is important to identify barriers and facilitators to adherence to social distancing to inform ongoing and future public health campaigns. | 2020-10-07 |
| 33027418 | These aspects are relevant for correct diagnosis and treatment, and for the potential development of vaccines. | 2020-10-07 |
| 33027420 | Finally, we also discuss patent protection issues, cost effectiveness and scalability of synthetic routes for some of the most studied repurposing candidates since these are key aspects to meet global demand for COVID-19 treatment. | 2020-10-07 |
| 33027466 | So far, there is no effective treatment to fight off COVID-19 and, despite many daily speculations about new treatments and vaccines, in this article, we discuss the effectiveness of a cheap and scientific proven technique to treat and prevent several diseases. | 2020-10-07 |
| 33027600 | Furthermore, we discuss the landscape of COVID-19 therapeutics that are currently in development in Canada. | 2020-10-07 |
| 33027755 | Respondents perceived that these changes had a positive impact on patient safety; treatment efficacy; patient and staff experience; and communication with patients, investigators, and sponsors. […] For remote consent, telehealth, therapy shipment, off-site diagnostics, and remote monitoring, individuals with personal experience with the specific change and individuals with >5 years’ professional experience were numerically more likely to recommend continuing the adjustment, and these differences were significant for telehealth (P=.04) and therapy shipment (P=.02). | 2020-10-07 |
| 33027847 | Due to public health policy and dental emergency management, the number of dental visitors to our clinic dropped sharply, and no COVID-19 suspected cases or high-risk patients received treatment. […] There have been no reports of infection of dental staff or patients during dental treatment in China to date. | 2020-10-07 |
| 33028398 | Both patients had multiple comorbidities, received a combination of antibiotics, steroids and supportive oxygen therapy, and underwent routine laboratory workup. | 2020-10-08 |
| 33028465 | Responses to PWUD that go beyond treatment–such as decriminalization and providing a safe supply of pharmaceutical-grade drugs–could reduce impacts of this syndemic. | 2020-10-08 |
| 33028485 | As it happens, such a statement would apply perfectly well to the story of chloroquine (CQ) and hydroxychloroquine (HCQ) in the COVID-19 infection: it has become a veritable saga, with conflicting views that have often gone beyond the normal scientific dialectic, and with conclusions that have frequently been polluted by non scientific opinions: thus, for instance, when National Agencies have taken positions against CQ and HCQ, the move has been seen as a pro-vaccine attempt to block low cost therapy means. | 2020-10-08 |
| 33028512 | We analysed admission data for LRTIs from 22 paediatric intensive care units (PICUs) in four countries, part of a large international Latin American registry of children with acute respiratory failure (Red Colaborativa Pediátrica de Latinoamérica [LARed Network]). | 2020-10-08 |
| 33028572 | A targeted COVID-19 treatment was initiated with hydroxicloroquine, corticosteroids, enoxaparine and a single dose of tocilizumab. | 2020-10-08 |
| 33028661 | Some members of the health care team want to enroll her in a randomized clinical trial evaluating an experimental treatment of COVID-19. | 2020-10-08 |
| 33028676 | Remdesivir is a broad-spectrum antiviral nucleotide prodrug that has been clinically evaluated in Ebola virus patients and recently received emergency use authorization (EUA) for treatment of COVID-19. […] The F548 residue is highly conserved in filoviruses but should be subject to specific surveillance among novel filoviruses, in newly emerging variants in ongoing outbreaks, and also in Ebola virus patients undergoing remdesivir therapy. | 2020-10-08 |
| 33028689 | Since asymptomatic patients have no clinical symptoms which can easily prevent timely diagnosis and treatment, they may cause a greater risk of virus transmission than symptomatic patients, which poses a major challenge to infection control. | 2020-10-08 |
| 33028774 | In the present case, a lung bulla was found on chest computed tomography during treatment for COVID-19. | 2020-10-08 |
| 33028810 | COVID-19, caused by SARS-CoV-2, lacks effective therapeutics. […] To identify starting points for such therapeutics, we performed a large-scale screen of electrophile and non-covalent fragments through a combined mass spectrometry and X-ray approach against the SARS-CoV-2 main protease, one of two cysteine viral proteases essential for viral replication. | 2020-10-08 |
| 33028965 | Here, we test a set of metallodrugs and related compounds, and identify ranitidine bismuth citrate, a commonly used drug for the treatment of Helicobacter pylori infection, as a potent anti-SARS-CoV-2 agent, both in vitro and in vivo. […] Our findings highlight viral helicase as a druggable target and the clinical potential of bismuth(III) drugs or other metallodrugs for the treatment of SARS-CoV-2 infection. | 2020-10-08 |
| 33028979 | Our study provides further evidence that targeted immunomodulatory therapy may be beneficial in specific patient subpopulations and can be informed by careful immune profiling. | 2020-10-08 |
| 33029064 | COVID-19 has presented numerous challenges to all aspects of health care, including reliable methods for diagnosis, treatment, and prevention. | 2020-10-08 |
| 33029094 | ShuFeng JieDu capsule (SFJDC), a traditional Chinese medicine, has been recommended for the treatment of COVID-19 infections. […] The results suggested that SFJDC cloud be treated COVID-19 by multi-compounds and multi-pathways, and this study showed that the mechanism of traditional Chinese medicine (TCM) in the treatment of disease from the overall perspective. | 2020-10-08 |
| 33029098 | Conclusions: Lung CT imaging combined with clinical and laboratory findings can facilitate early diagnosis and appropriate management of COVID-19 pneumonia with a history of malignancy and radiation therapy. | 2020-10-08 |
| 33029105 | In this review, we will focus on cytokine storm in COVID-19 patients, their impact on the body organs, and the potential treatment by QTY code-designed detergent-free chemokine receptors. | 2020-10-08 |
| 33029165 | Presently, there is no effective treatment for COVID-19. […] Our findings suggest the potential effectiveness of Cat’s claw as complementary and/or alternative medicine for COVID-19 treatment. | 2020-10-08 |
| 33029193 | The ADE (adverse drug event) signal detection based on FAERS is helpful to clarify the potential adverse events related to ribavirin-interferon combination for novel coronavirus therapy; clinicians should pay attention to the adverse reactions of gastrointestinal and blood systems, closely monitor the fluctuations of the platelet count, and carry out necessary mental health interventions to avoid serious adverse events. | 2020-10-08 |
| 33029203 | Patients were asked for confirmed SARS-CoV-2 infection, symptoms suggestive of COVID-19, and modification of their therapy. […] Interstitial lung disease (ILD) was present in 45% of patients and most of them (68.2%) were treated with immunosuppressive therapy. […] Nobody modified the therapy during the COVID-19 outbreak. | 2020-10-08 |
| 33029325 | Delivering trauma-focused cognitive behavioural therapy to patients with PTSD during the COVID-19 pandemic poses challenges. […] The therapist cannot meet with the patient in person to guide them through trauma-focused work and other treatment components, and patients are restricted in carrying out treatment-related activities and behavioural experiments that involve contact with other people. […] Cognitive therapy for PTSD (CT-PTSD) is a trauma-focused cognitive behavioural therapy that is acceptable to patients, leads to high rates of recovery and is recommended as a first-line treatment for the disorder by international clinical practice guidelines. […] Here we describe how to deliver CT-PTSD remotely so that patients presenting with PTSD during the COVID-19 pandemic can still benefit from this evidence-based treatment. | 2020-10-08 |
| 33029451 | The cases of coronavirus disease 2019 (COVID-19) are very less in neonates and they recover well with supportive treatment. […] Based on available evidence, antivirals like lopinavir, ritonavir, remdesivir specific medication like chloroquine/hydroxychloroquine, azithromycin, corticosteroids, and intravenous gamma globulin, are not recommended, so early detection and supportive treatment is needed for an optimal outcome. | 2020-10-08 |
| 33029494 | Close monitoring and timely treatment are needed for high-risk COVID-19 patients. | 2020-10-08 |
| 33029499 | Passive immunization is the therapy born from the intuition of Behring and Kisato in the late 19th century. […] It was widely used for the treatment of bacterial infections until the discovery of antibiotics, as well as during the viral pandemics of the 20th century and of the beginning of the 21st; it still has clinical applications (e.g., tetanus prevention). […] Recently, in 2017, the WHO Blood Regulators Network (BRN) published a position paper, recommending convalescent plasma as the first-choice treatment to be tested in the absence of authorized drugs; however, this strategy has not been followed. […] The first reported results are encouraging and confirm the effectiveness of plasma therapy and its safety. […] Also, the FDA has proposed plasma treatment in order to face the increasingly complex situation and manage patients with serious or immediately life-threatening COVID-19 disease. | 2020-10-08 |
| 33029513 | The absence of approved therapeutics to combat this disease threatens the health of all persons on earth and could cause catastrophic damage to society. | 2020-10-08 |
| 33029526 | We assess the impact this situation had on our caseload and what conclusions can be drawn about the wider impact of the pandemic in oncological therapy in Portugal. […] Case reduction was observed at hospitals that have mostly been involved in the treatment of COVID-19 and in the north of the country, the region worst-hit by the pandemic. | 2020-10-08 |
| 33029696 | The lack of an approved drug treatment regimen, and non-availability of a vaccine, collectively posed a challenge for mankind to fight against the SARS-CoV-2 pandemic. […] In this scenario, repurposing of existing drugs and old treatment options like convalescent plasma therapy can be one of the potential alternatives to treat the disease. […] For this, we used “Boolean Operators” such as AND, OR & NOT to search relevant research articles/reviews from the PUBMED for the repurposed drugs and the convalescent plasma in the COVID-19 treatment. […] Although, the vaccine would be an ideal option for providing active immunity against the SARS-CoV-2, but considering the current situation, drug repurposing and convalescent plasma therapy and repurposed drugs are the most viable option against SARS-CoV-2. | 2020-10-08 |
| 33029761 | Recent outbreaks, such as influenza, coronavirus, Ebola, and dengue, have emphasized the urgent need for new antiviral therapeutics. […] Considerable efforts have focused on developing metal nanoparticles for the treatment of several pathogenic viruses. […] This review summarizes the application of metal nanoparticles for the treatment of viral infections. | 2020-10-08 |
| 33029768 | Currently, no specific treatment and authorized vaccines are available for its treatment. | 2020-10-08 |
| 33029911 | Hydroxychloroquine (HCQ) is commonly used in the treatment of malaria and rheumatic diseases. | 2020-10-08 |
| 33030009 | The main current issues are selection of patients for surgical treatment, principles of surgical treatment in cancer patients, possibilities of endoscopic surgery, organization of surgical department and operating theatre, surgical strategy in infected patients. […] Own experience and rational implementation of the recommendations developed by international research and practical communities are extremely important for optimizing surgical treatment of patients in a pandemic, as well as for ensuring the safety of patients and medical staff. | 2020-10-08 |
| 33030102 | This pandemic created the need for all viable treatment strategies available in the market. | 2020-10-08 |
| 33030105 | A similar MD analysis of a few antiviral drugs which are under clinical trials or approved for COVID-19 treatment showed them inferior to both select ligands in terms of stabilizing the RBD globally and locally at binding sites. […] Because of the crucial role of the S protein in virus virulence, our results highly propose ritonavir and naloxegol as the potentially helpful therapeutics against COVID-19, mandating appropriate clinical trials. | 2020-10-08 |
| 33030318 | These similarities include emphasis on the importance of hand washing, prohibition of gatherings (and disregard of these rules), disruption of public life, uncertainty about the nature of the cause, praise of and warnings against ineffective medication as well as debate on use and necessity of certain measures. | 2020-10-08 |
| 33030322 | Since there is no adequate treatment for COVID-19, prevention of the transmission of SARS-CoV2 is the best way to cope with the pandemic. | 2020-10-08 |
| 33030369 | People with chronic pain faced potential treatment disruption during the COVID-19 pandemic in Singapore, as the focus of healthcare shifted. […] Telemedicine and home visits by community nurses were used, with risk-mitigation measures, ensuring comprehensive assessment and treatment compliance. | 2020-10-08 |
| 33030591 | This also influences the psychological treatment options of patients with headache. […] The present article intends to illustrate the different psychological forms of treatment for headache patients and their implementation during the COVID-19 pandemic. […] Even during the COVID-19 pandemic, psychological treatment enables the increased stress level in headache patients to be counteracted by using cognitive behavioral therapy and relaxation techniques. […] The digital implementation of psychological approaches makes a major contribution to maintaining psychological treatment of headache patients, so that the individually changed needs can be addressed. | 2020-10-08 |
| 33030607 | To report on efficacy and safety of intravenous immunoglobulin (IVIg) therapy in a case series of patients with COVID-19-related encephalopathy. […] Our preliminary findings suggest that IVIg may represent a safe and effective treatment for COVID-19-associated encephalopathy. | 2020-10-08 |
| 33030622 | Diagnosis, treatment strategy, and timing were compared between the two cohorts to define temporal trends. […] Similar proportions of patients underwent reperfusion (45.9% in 2019 vs 53.4% in 2020), although a slight increase in combined treatment was detected (14.4% vs 25.4%, p = .05). […] Door-to-scan timing was significantly prolonged in 2020 compared with 2019 (28.4 ± 12.6 vs 36.7 ± 14.6, p = .03), although overall timing from stroke to treatment was preserved. […] Longer stroke-to-call and door-to-scan times, attributable to change in citizen behavior and screening at hospital arrival, did not impact on stroke-to-treatment time. | 2020-10-08 |
| 33030986 | Rates of medication dispensing errors (MDEs) and its subcategories, prescription-related errors, and pharmacist counseling errors across pharmacies with telepharmacy versus those without remote services were (15.81% vs. | 2020-10-08 |
| 33031009 | Kymriah is an innovative cancer therapy which works by removing disease fighting T-cells from patients, genetically modifying or reprogramming the immune cells to attack cancer, and re-infusing them back into the patients. […] The cost of this new hope-giving gene therapy is CHF 450,000 per treatment. […] This exorbitantly high price set by Novartis, in exercise of its exclusive rights resulting from patent protection, undermines the real-world impact of this revolutionary therapy. | 2020-10-08 |
| 33031010 | A cross-sectional survey, including questions about demographics, concerns of COVID-19 impact on cancer treatment and outpatient clinic visits, and the European Organization for Research and Treatment of Cancer (EORTC) QLQ-C30 questionnaire was sent to patients with cancer at the Department of Oncology, Odense University Hospital, Denmark. […] Factors associated with being concerned of contracting COVID-19 were comorbid conditions, incurable cancer, receiving medical cancer treatment and female gender. | 2020-10-08 |
| 33031013 | Models adjusting for potential confounding variables, including medication-assisted treatment and treatment at a substance use disorder facility indicated that the risk for non-prescribed fentanyl positivity rose by more than 50% during the pandemic. | 2020-10-08 |
| 33031044 | The COVID-19 pandemic has required transitioning many clinical addiction treatment programs to telephonic or virtual visits. […] Novel solutions are needed to enhance substance use treatment during a time when many patients are disconnected from clinical care and social supports. […] Digital phenotyping, which leverages the unique functionality of smartphones sensors (GPS, social behavior, and typing patterns), can buttress clinical treatment in a remote, scalable fashion. | 2020-10-08 |
| 33031046 | Behavioral activation is considered an evidence-based treatment for MDD. | 2020-10-08 |
| 33031049 | The COVID-19 pandemic has spread with alarming speed and an effective treatment for the disease is still lacking. | 2020-10-08 |
| 33031060 | We analyzed the clinical manifestations, changes in CT scan images, and laboratory tests before and after tocilizumab treatment, and compared these results with the conventionally treated group. […] These findings suggest tocilizumab improves clinical outcomes and is effective for treatment of patients with critical or severe COVID-19. […] However, future clinical trials are needed to better understand the impact of tocilizumab interference with IL-6 and provide a therapeutic strategy for treatment of COVID-19. | 2020-10-08 |
| 33031080 | Clinical trials in this field are then urgently needed in line of vaccine and treatment unavailability. | 2020-10-08 |
| 33031081 | COVID-19 has become a global health security issue, it has caused more than half a million deaths worldwide so far, the treatment strategies are the most concerned issues for clinicians. […] Multivariable analysis was performed to evaluate cure rate at 14 days with different drug treatment. […] The cure rate was increased with the treatment time extended and 90% of pediatric patients were cured and discharged after 14 days’ treatment. […] And multivariable analysis results proved that none of the covariates were related to the cure rate at 14 days with different drug treatment since p values were over 0.05. | 2020-10-08 |
| 33031085 | As an adjunctive therapy budesonide was used that seems to contribute to the clinical improvement. | 2020-10-08 |
| 33031143 | Most SARS-CoV-2 positive neonates were referred to government-designated COVID-19 hospitals, leading to gaps in treatment. | 2020-10-08 |
| 33031192 | Given the relationship of SARS-CoV-2 with the renin angiotensin aldosterone system, further evaluation of angiotensin II for the treatment of COVID-19 related shock is warranted. | 2020-10-08 |
| 33031213 | While the presented results are promising, researchers must continue monitoring and exploring the clinical and humanistic impact of COVID-19 on the treatment of substance use disorders. | 2020-10-08 |
| 33031311 | There is currently no specific and effective drug treatment. […] However, there is no evidence-based medicine to confirm the effectiveness and safety of DPP-4 inhibitors in the treatment of COVID-19 patients with diabetes. […] This study will explore the effectiveness and safety of DPP-4 inhibitors in the treatment of COVID-19 patients with diabetes. […] It will provide evidence-based medical evidence for DPP-4 inhibitors in the treatment of diabetes with COVID-19. | 2020-10-08 |
| 33031341 | The study aims to evaluate the effectiveness and safety of acupuncture therapy for asymptomatic infection of COVID-19. | 2020-10-08 |
| 33031350 | Eighteen required renal replacement therapy and 17 died. | 2020-10-08 |
| 33031368 | Model simulations indicate that whether the extent of tissue damage may be exacerbated by ACEi or ARB treatment depends on a number of factors, including the level of existing inflammation, dosage, and the effect of the drugs on ACE2 protein abundance. | 2020-10-08 |
| 33031409 | This off label-treatment was based on preclinical studies in mice with LPS-induced ARDS, where inhaled adenosine/A2AR agonists protected oxygenated lungs from the deadly inflammatory damage. […] The treatment was allowed, considering that adenosine has several clinical applications. […] Fourteen consecutively enrolled patients with Covid19-related interstitial pneumonitis and PaO2/FiO2 ratio<300 received off-label-treatment with 9 mg inhaled adenosine every 12 hours in the first 24 hours and subsequently, every 24 days for the next 4 days. […] The treatment was well tolerated with no hemodynamic change and one case of moderate bronchospasm. | 2020-10-08 |
| 33031464 | Changes in the delivery of diagnostics (diagnostic endoscopy), imaging for staging, therapeutics and surgical technique in the management of colorectal cancer. […] Neoadjuvant therapy use in rectal cancer changed in 48% of responses, where centers which had ceased surgery increased its use (62 vs 30%, p = 0.04) as did those with extended delays to surgery (p<0.001). | 2020-10-08 |
| 33031500 | The intended remdesivir treatment course was 10 days (200mg on Day 1, followed by 100mg for Days 2-10, given intravenously). | 2020-10-08 |
| 33031532 | We evaluated the proportion of cancer patients tested for COVID-19 who were positive, as well as outcome attributable to COVID-19, and stratified by clinical characteristics including demographics, comorbidities, cancer treatment and cancer type. […] Conversely, prevalence was lower in current smokers and patients who recently received cancer therapy (<6 months). […] Recent (<6 months) or past treatment did not influence attributable mortality. […] The overall COVID-19 attributable mortality in cancer patients is affected by age, comorbidity and specific cancer types, however, race or recent treatment including immunotherapy does not impact outcome. | 2020-10-08 |
| 33031602 | Understanding the possible mechanism that protects the children from hyper-inflammatory or disease severity could lead to better treatment modalities. | 2020-10-08 |
| 33031623 | The world has focused on developing treatment and controlling measures against COVID-19. […] Currently, there is no specific approved therapy or medication for the disease, therefore this pandemic situation demonstrates the immediate need for wide-ranging antiviral countermeasures to SARS-CoV-2 and future coronaviruses. | 2020-10-08 |
| 33031651 | Doctors involved in clinical services in outpatient departments, designated COVID-19 wards, screening blocks, fever clinics, and intensive care units completed an online questionnaire. […] Regular screening of medical personnel involved in the diagnosis and treatment of patients with COVID-19 should be conducted to evaluate for stress, anxiety, and depression. | 2020-10-08 |
| 33031726 | It is difficult to differentiate the symptoms or radiological images of the lung cancer patient with COVID 19 pneumonia vs cancer progression or treatment-related complications. | 2020-10-08 |
| 33031729 | Lopinavir-ritonavir combination and azithromycin treatments were given, and the patient’s symptoms regressed with treatment. | 2020-10-08 |
| 33031764 | Lopinavir-ritonavir has been proposed as a treatment for COVID-19 on the basis of in vitro activity, preclinical studies, and observational studies. […] Eligible and consenting patients were randomly allocated to either usual standard of care alone or usual standard of care plus lopinavir-ritonavir (400 mg and 100 mg, respectively) by mouth for 10 days or until discharge (or one of the other RECOVERY treatment groups: hydroxychloroquine, dexamethasone, or azithromycin) using web-based simple (unstratified) randomisation with allocation concealment. […] Randomisation to usual care was twice that of any of the active treatment groups (eg, 2:1 in favour of usual care if the patient was eligible for only one active group, 2:1:1 if the patient was eligible for two active groups). […] These findings do not support the use of lopinavir-ritonavir for treatment of patients admitted to hospital with COVID-19. | 2020-10-08 |
| 33031791 | Currently, there is no vaccine to prevent infection nor any approved drug for the treatment. […] In such a situation, the drug repurposing becomes an attractive solution to identify the potential of COVID-19 treatment by existing drugs, which are approved for other indications. […] Here, we review the potential use of rapamycin, an mTOR (Mammalian Target of Rapamycin) inhibitor that can be repurposed at low dosages for the treatment of COVID-19. […] Since, rapamycin targets the host factors and not viral machinery, it represents a potent candidate for the treatment of COVID-19 than antiviral drugs as its efficacy is less likely to be dampened with high mutation rate of viral RNA. […] Therefore, by drug repurposing, low dosages of rapamycin can be tested for the potential treatment of COVID-19/SARS-CoV-2 infection. | 2020-10-08 |
| 33032013 | Neuropsychiatric symptoms resolved following treatment with tocilizumab. | 2020-10-08 |
| 33032174 | While COVID-19 continues to spread across the globe, diligent efforts are made to understand its attributes and dynamics to help develop treatment and prevention measures. | 2020-10-08 |
| 33032267 | As the number of chest CT images increase rapidly, manual severity assessment becomes a labor-intensive task, delaying appropriate isolation and treatment. | 2020-10-08 |
| 33032282 | Hydroxychloroquine (HQ) has been used for the treatment of novel coronavirus disease (COVID-19) even though there is no clear evidence for its effectiveness yet. […] We herein present 2 cases of sudden cardiac death in 2 ESRD patients with COVID-19 for whom a treatment regimen including HQ was preferred. […] Electrocardiography controls upon admission and on the 24 and 48 h of treatment showed normal QTc intervals. […] Potential risks contributing to sudden cardiac death during HQ treatment of ESRD patients are discussed. | 2020-10-08 |
| 33032333 | Further, educational activities that focus on variations in treatment protocols for various infections should be introduced particularly those that concern indications for antimicrobial prescribing. | 2020-10-08 |
| 33032387 | Further, studies are needed to learn more about the influence that the COVID-19 pandemic has on the treatment of patients with acute and chronic aortic disease. | 2020-10-08 |
| 33032593 | Only urgent treatment of dental diseases can be performed during the COVID-19 outbreak taking into consideration pharmacological management as the first line and contagion-reduced minimally invasive emergency treatment as the secondary and final management. […] While the currently available evidence has not demonstrated a clear and direct relationship between dental treatment or surgery and the possibility of the transmission of COVID-19, there is clearly the potential for transmission. | 2020-10-09 |
| 33032660 | In this population-based registry study, we collected de-identified data on clinical characteristics, treatment and outcomes in adult patients with hematologic malignancies and confirmed severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection within the Madrid region of Spain. […] We assessed the association between mortality and potential prognostic factors using Cox regression analyses adjusted for age, sex, comorbidities, hematologic malignancy and recent active cancer therapy. […] Age ≥ 60 years (hazard ratios 3.17-10.1 vs < 50 years), > 2 comorbidities (1.41 vs ≤ 2), acute myeloid leukemia (2.22 vs non-Hodgkin lymphoma) and active antineoplastic treatment with monoclonal antibodies (2·02) were associated with increased mortality; conventional chemotherapy showed borderline significance (1.50 vs no active therapy). […] Conversely, Ph-negative myeloproliferative neoplasms (0.33) and active treatment with hypomethylating agents (0.47) were associated with lower mortality. […] Overall, 574 (82%) patients received antiviral therapy. […] Mortality with severe/critical COVID-19 was higher with no therapy vs any antiviral combination therapy (2.20). […] In this series of patients with hematologic malignancies and COVID-19, mortality was associated with higher age, more comorbidities, type of hematological malignancy and type of antineoplastic therapy. | 2020-10-09 |
| 33032817 | COVID-19 pandemic results in a significant reduction in emergent reperfusion therapy, and a trend toward higher in-hospital adverse events risk. | 2020-10-09 |
| 33032841 | Paradoxically, the patient with more risks of developing a severe disease, a 64-year-old woman, 2-years liver transplant recipient under treatment with tacrolimus, presented a similar outcome compared to the two other members of the family. | 2020-10-09 |
| 33032860 | This research note underscores the importance of ensuring a sufficient quantity of methadone take-home doses for patients on methadone maintenance treatment (MMT) to maximize their adherence to government-imposed lockdown restrictions and social distancing measures designed to curtail the spread of SARS-CoV-2. […] We evaluate the impact of COVID-19 on take-home medication (number of days provided) in a methadone clinic in Barcelona (Catalonia, Spain). | 2020-10-09 |
| 33032862 | Some supportive housing environments in Vancouver, British Columbia, have on-site primary care and substance use disorder treatment clinics. […] Other modifications to the OUD care continuum included modified supervised injection spaces to adhere to physical distancing, the use of personal protective equipment for overdose response, virtual platforms for clinical encounters, writing longer prescriptions, and providing take-home doses to promote opioid agonist treatment retention. | 2020-10-09 |
| 33032880 | The USA and UK will be used as specific examples, as will the general case of delayed cancer treatment due to COVID-19 service disruption. | 2020-10-09 |
| 33032909 | Strategies for risk mitigation have been extrapolated from reports dealing with other viruses to the current global crisis, for safety in fertility treatment services in general, and specifically for oncofertility. | 2020-10-09 |
| 33032962 | In times of the COVID-19 pandemic, the temporary approval of video therapy enables the maintenance of speech therapy treatment. […] This leads to the necessity to investigate the effectiveness of screen-to-screen-therapy via a video conferencing system compared to conventional face-to-face-therapy of adult aphasia patients. […] We included German- and English-language studies comparing the effectiveness of a classic face-to-face-therapy with a screen-to-screen-therapy of adults with aphasia. […] Both face-to-face-therapy and screen-to-screen therapy showed significant improvements in naming performance in an Italian crossover study, a Canadian randomized study and a quasi-randomized study conducted in the UK. […] In a German comparative study, significant improvements in naming performance were found for face-to-face therapy, but the results did not differ significantly from the screen-to-screen-therapy intervention group. […] In all included studies, screen-to-screen-therapy and face-to-face-therapy had a comparable effectiveness on naming performance. […] The results demonstrate the feasibility of a screen-to-screen-therapy under everyday conditions. […] However, it is possible that this form of therapy cannot always be implemented. […] Barriers to screen-to-screen-therapy can be the use of technologies and restrictions in the visual field due to a neglect. […] For many patients screen-to-screen-therapy is currently the only possibility to receive speech therapy treatment. […] Therefore it is a positive aspect that screen-to-screen-therapy is as effective as face-to-face-therapy. […] Screen-to-screen-therapy can provide expanded access to health care and professional expertise in health services. […] In this way, speech therapy care during the COVID-19 pandemic can be largely maintained. […] Further research is needed on evidence-based treatment methods and user-oriented apps for video therapy. | 2020-10-09 |
| 33033045 | This scenario can be particularly challenging in endovascular stroke treatment, which is a highly specialized task that requires seamless cooperation of numerous health care workers across various specialties and professions. […] This document is intended for stroke teams who face the challenge of integrating new team members into endovascular stroke-treatment workflows during the COVID-19 pandemic or any other global health care emergency. […] While these 4 key principles should generally be followed in endovascular stroke treatment, they become even more important during health care emergencies such as the COVID-19 pandemic, when health care professionals have to take on new and additional roles and responsibilities in challenging working environments for which they were not specifically trained. | 2020-10-09 |
| 33033132 | We concentrated, extracted, and sequenced nucleic acids from 17 composite influent wastewater samples spanning seven southern California wastewater treatment facilities in May 2020. | 2020-10-09 |
| 33033166 | The decreased accessibility of the medical services and postponed diagnosis of potentially curable cancers during the COVID-19 pandemic may be a step backwards in our healthcare system and might impair cancer treatment outcomes. | 2020-10-09 |
| 33033170 | Angiotensin converting enzyme 2 (ACE2), a crucial factor in COVID-19 pathogenesis, has been identified as a potential target for COVID-19 treatment. | 2020-10-09 |
| 33033248 | Our study may point to distinct stages of progression of COVID-19 lung disease and highlights the need for peripheral blood biomarkers that inform about patient lung status and guide treatment. | 2020-10-09 |
| 33033344 | In order to develop anti-viral therapeutics for SARS-CoV-2, it is crucial to find amino acid pairs that strongly attract each other at the interface of the spike glycoprotein and the human angiotensin-converting enzyme 2 (hACE2) complex. […] The 3D-SPIEs-based map would provide valuable information to develop anti-viral therapeutics that inhibit PPIs between the spike protein of SARS-CoV-2 and hACE2. | 2020-10-09 |
| 33033405 | Preemptive therapy with tocilizumab was safe and associated with favorable outcomes in most patients. | 2020-10-09 |
| 33033507 | Among the booming literatures about COVID-19, there is yet a paucity of study addressing the association between COVID-19 and cancer, which is a rare comorbidity of COVID-19, as well as consensus for treatment of cancer in this pandemic. […] Methods: In this retrospective, single-center cohort study, information of all inpatient cases with laboratory-confirmed COVID-19 who had treatment outcome were collected from the designated departments in Zhongnan Hospital of Wuhan University, Wuhan, China on March 10, 2020. […] Demographic data, clinical information, and treatment outcomes were extracted from electronic medical records. […] Among COVID-19 patients with cancer, we found that patients older than 60 years (75%), with other comorbidities (50%), or experiencing anticancer treatment in past month (42.9%) had a numerically higher incidence of severe events. […] We propose that personalized treatment recommendation for cancer patients should be addressed during COVID-19 pandemic, along with meticulous personal protective protocols for them to mitigate the risk of SARS-CoV-2 infection. | 2020-10-09 |
| 33033561 | To date, there is no effective antiviral therapy for COVID-19 patients, and therapeutic strategies are based on experience treating previously recognized coronaviruses. […] In search of new treatment modalities of COVID-19, cell-based therapy with mesenchymal stem cells (MSCs) and/or their secretome, such as soluble bioactive factors and extracellular vesicles, is considered supportive therapy for critically ill patients. | 2020-10-09 |
| 33033619 | As the human and economic toll of the COVID-19 coronavirus steadily escalates, there is extreme uncertainty regarding the timeframe for prevention, detection, and treatment. | 2020-10-09 |
| 33033686 | Treatment options are limited and mostly rely on supportive care. […] Icosapent ethyl (IPE) is an Omega-3 fatty acid derivative that has been shown to significantly reduce cardiovascular mortality and is used as an adjunct to statin therapy. […] Here, we describe, for the first time, the successful treatment of a COVID-19 patient with IPE. | 2020-10-09 |
| 33033702 | New areas such as interactions with patients’ groups, leading treatment access in specific channels of health-care delivery and role in specialty care are likely to be an integral part of the Medical Affairs function. | 2020-10-09 |
| 33033703 | A substantial number of COVID 19 patients will receive investigational drugs along with multiple other medications for clinical manifestations and drug therapy for lifestyle diseases. | 2020-10-09 |
| 33033851 | These observations may discern immunopathology, treatment targets, and long-term monitoring strategies for other patients undergoing immunotherapy or with cytokine storm. | 2020-10-09 |
| 33033884 | Currently, there is no definitive therapy for COVID-19 or associated complications, and with the hope of a safe and effective vaccine in the distant future, the search for an answer is paramount. […] In this manuscript, we reviewed the current evidences and explored the potential therapeutic use of allogenic UC and/or WJ-derived MSCs for the treatment of COVID-19. […] Although, preliminary preclinical and clinical studies indicate that their use is safe and potentially effective, more multi-center, randomized, controlled trials are needed to adequately assess the safety and efficacy of UC and/or WJ-derived MSCs for the treatment of COVID-19. | 2020-10-09 |
| 33034038 | Data regarding demographics, disease characteristics and therapy were confirmed by chart review. | 2020-10-09 |
| 33034095 | Convalescent plasma therapy for COVID-19 relies on transfer of anti-viral antibody from donors to recipients via plasma transfusion. […] We investigated predictors of convalescent antibody production and quantified recipient antibody response in a convalescent plasma therapy clinical trial. | 2020-10-09 |
| 33034142 | To maintain clinical standards whilst ensuring patient safety, we discuss the importance of triage, information gathering, symptom assessment and early review of response to treatment. | 2020-10-09 |
| 33034209 | The disease course of COVID-19 appears to be milder in children than in adults, and the treatment course primarily consists of supportive care. | 2020-10-09 |
| 33034240 | Therapy was initiated with subcutaneous low-molecular-weight heparin, and the patient was discharged at 20 days asymptomatic. […] Our case illustrates vascular complications in a COVID-19 patient and its effective treatment with anticoagulation. | 2020-10-09 |
| 33034267 | We sought to perform a critical review of the available literature regarding decontamination methods to determine which strategies are effective at inactivating the target organism, preserve performance (filter efficiency and fit) of the respirator, leave no residual toxicity from the treatment, and are fast-acting, inexpensive, and readily available. […] Further, UVGI (among other treatment methods) has been recommended by the Centers for Disease Control and Prevention (CDC), Occupational Safety and Health Administration (OSHA), and respirator manufacturers. […] Methods involving microwave-generated steam also show potential in that they are likely effective against SARS-CoV-2, preserve performance, have no residual toxicity, require a short duration treatment cycle (often less than 10 min), and microwave ovens are inexpensive and readily available. | 2020-10-09 |
| 33034449 | Concerted efforts by physicians, academic laboratories, and companies around the world have improved detection and treatment and made promising early steps, developing many vaccine candidates at a pace that has been unmatched for prior diseases. | 2020-10-09 |
| 33034546 | Demographic, clinical, laboratory and neuroimaging data were collected along with treatment administered and outcomes. | 2020-10-09 |
| 33034577 | During this pandemic period, the need to exclude the possibility of COVID-19 pneumonia in patients with acute dyspnea may cause a delay in the diagnosis and treatment of patients with acutely decompensated HF who have similar symptoms. | 2020-10-09 |
| 33034585 | The full effect on access to medical care and the treatment for patients with chronic diseases and acute conditions is still unknown. | 2020-10-09 |
| 33034674 | The rehabilitation process following cochlear implant (CI) surgery is carried out in a multimodal therapy according to German national guidelines and includes technical and medical aftercare. […] Demographics were analyzed and the quality of medical aftercare, speech therapy, technical aftercare, psychological support and the hygiene modalities were compared to previous rehabilitation stays. […] The quality of rehabilitation and individual therapy were rated as qualitatively similar or improved. | 2020-10-09 |
| 33034683 | The COVID-19 pandemic necessitated a time-critical expansion of medical staff in intensive care units (ICU) and emergency rooms (ER). […] In the ICU they assisted with preparing catheter systems, medication and nursing, performed Manchester triage and initial care in the ER. | 2020-10-09 |
| 33034695 | Sera of animal origin and hyperimmunoglobulins have dominated serum therapy for a century. […] Although numerous monoclonal antibodies (MABs) have been developed since the end of the 1980s, particularly for the treatment of immunological and oncological diseases, it will take 20 years before the first anti-infective MAB is approved in the European Union. […] Interestingly, to combat the COVID-19 pandemic, numerous MABs, which are approved in particular for immunological indications, are currently being used to treat the consequences of SARS-CoV‑2 infection, such as pneumonia or hyperimmune reactions.The approved monoclonal antibodies for the treatment of infectious diseases are presented here. […] In addition, an overview of the current developments, in particular in the treatment of SARS-CoV‑2 infection, is provided. | 2020-10-09 |
| 33034824 | In order to dispense this current crisis, numerous treatment options have been tried and tested and many more are still under scrutiny. […] In this review we highlight the new discoveries and furtherance in the antibody based therapeutic options and the potent drugs, with special emphasis on the development of the monoclonal and polyclonal antibodies and the repurposed drugs, which may prove to be of significant importance for the treatment of COVID-19, in the days to come. | 2020-10-09 |
| 33035175 | Patients with coronavirus disease (COVID-19) in ICU have a high mortality rate, and how to early assess the prognosis and carry out precise treatment is of great significance. | 2020-10-09 |
| 33035176 | While the trigger for the development of each of these templates was the COVID-19 pandemic, the templates represented a variety of types of data sets - symptom screening; infection report; clinical decision support for diagnosis and treatment; and secondary use/research. | 2020-10-09 |
| 33035183 | The time-dependent prognostic value of the laboratory parameters analyzed in this study can be used by clinicians for the effective treatment of the patients and for the proper management of intensive care beds, which becomes a critical issue during the pandemic peaks. | 2020-10-09 |
| 33035201 | Rapid and specific antibody testing is crucial for improved understanding, control, and treatment of COVID-19 pathogenesis. | 2020-10-09 |
| 33035296 | Success will require fundamentally changing HIV prevention and care delivery to engage more persons with HIV and at-risk of HIV in treatment. […] These included the use of telehealth, medication delivery to the home and increased flexibility facilitating access to Ryan White HIV/AIDS Program services. | 2020-10-09 |
| 33035373 | Due to the lack of effective medication or vaccine for COVID-19, timely detection of this viral infection and distinguishing from influenza are very important. | 2020-10-09 |
| 33035643 | Nevertheless, no vaccine or therapeutic drug is yet to be approved for the treatment of SARS-CoV-2, although it is highly likely that new effective medications that target the virus specifically will take years to establish. | 2020-10-09 |
| 33035649 | Data about five items reflecting clinical routines for persons who died an expected death from COVID-19 during the first three months of the pandemic (March-May 2020) were collected from the Swedish Register of Palliative Care. […] Four of the five items differed for total COVID-19 group compared to the reference cohort: fewer were examined by a physician during the last days before death, pain and oral health were less likely to be assessed, and fewer had had a specialised palliative care team consultation (p < .0001, respectively). | 2020-10-09 |
| 33035673 | In severe COVID-19 patients receiving TCZ due to systemic host-immune inflammatory response syndrome, the use of CS in addition to TCZ therapy, showed beneficial effect in preventing in-hospital mortality. | 2020-10-09 |
| 33035967 | Numerous randomized trials are ongoing to find an effective, safe and widely available treatment. […] Remdisivir is the only FDA -approved antiviral agent for treatment of severe COVID-19. […] Glucocorticoids (GCs) have been used for treatment of cytokine storm syndrome and respiratory failure in hospitalized patient with severe covid-19. | 2020-10-09 |
| 33035991 | Patient’s baseline characteristics including age, sex, comorbidities, cancer type and type of anticancer treatment were collected. […] One hundred and six patients (42.1%) received active anticancer treatment in the last 3 months before COVID-19 diagnosis. | 2020-10-09 |
| 33036545 | Managing infection control of the Corona virus disease (Covid-19) could be very challenging for substance use disorder (SUD) residential treatment programs. | 2020-10-10 |
| 33036662 | Signing informed consent and willingness of study participant to accept randomization to any assigned treatment arm Exclusion criteria: 1. […] Pregnancy and breastfeeding INTERVENTION AND COMPARATOR: Intervention group: The standard treatment regimen for COVID-19 along with Ginger-based herbal tablets (Vomigone ®, Dineh Pharmaceutical Company, Iran) at a dose of 1000 mg three times a day for a period of seven days. […] The standard treatment for COVID-19 based on the Iranian Ministry of Health and Medical Education’s protocol, along with Vomigone-like placebo tablets (Dineh Pharmaceutical Company, Iran) at a dose of two tablets three times a day for a period of seven days. | 2020-10-10 |
| 33036742 | The long-term care of cancer patients from their homes contributes to a deterioration in the quality of life linked to travel times, a delay in the care of potential treatment complications, and the spread of infectious diseases, such as COVID-19, and bacteria resistant to antibiotics. | 2020-10-10 |
| 33036761 | Eleven days after the cesarean section the patient began to develop hypertension that required treatment. […] SARS-CoV-2 genome sequencing in spinal fluid could have provided a definitive diagnosis, but the treatment would not have differed. | 2020-10-10 |
| 33036762 | Each healthcare center has been compelled to adapt the treatment guidelines established by the different scientific societies. | 2020-10-10 |
| 33036861 | Emergency services and intensive care units (ICUs) were faced with a novel disease with unknown clinical characteristics and presentations. | 2020-10-10 |
| 33036894 | Following treatment, his respiratory status worsened. […] The patient’s circulatory dynamics did not improve on medication, and he died on day 16. | 2020-10-10 |
| 33036903 | Delays were longer in Europe than in the Americas for kidney cancer (SRM follow-up, P = 0.014), prostate cancer (new visits, P = 0.003), and intravesical therapy for intermediate-risk bladder cancer (P = 0.043). | 2020-10-10 |
| 33036935 | When asked about resources needed to enable pharmacists to prescribe antiviral therapy, 37% of the pharmacists indicated they needed additional education or training, and 39% required access to technology to bill and document provided services. | 2020-10-10 |
| 33037151 | The urgent need for an effective treatment together with a lack of small animal infection models has led to clinical trials using repurposed drugs without preclinical evidence of their in vivo efficacy. […] Treatment of SARS-CoV-2-infected hamsters with a low dose of favipiravir or hydroxychloroquine with(out) azithromycin resulted in, respectively, a mild or no reduction in virus levels. | 2020-10-10 |
| 33037212 | Early detection of COVID-19 based on chest CT enables timely treatment of patients and helps control the spread of the disease. | 2020-10-10 |
| 33037393 | This perspective suggests to enhance STAT1 activity and/or inhibit STAT3 functions for COVID-19 treatment. | 2020-10-10 |
| 33037459 | Outbreaks of infectious diseases pose particular challenges for hospitals and intensive care units. […] Selected pathogens/infectious diseases that have significantly strained the resources of intensive care units are described. […] Multidisciplinary teams, protocol development, adequate staffing, and training are required to achieve optimal treatment outcomes, including prevention of healthcare worker infections. | 2020-10-10 |
| 33037564 | Currently, no specific treatment against SARS-CoV-2 are available; only prevention and supportive strategy are the preventive measures. […] Recent interest in SARS-CoV-2 has focused on transmission, symptoms, structure, and its structural proteins that exhibit promising therapeutics targets for rapid identification of potential inhibitors. […] We also tried to give an overview of the functional food components as a nutritional supplement, which helps in boosting our immune system and could be useful in preventing the COVID-19 and/or to improve the outcome during therapy. | 2020-10-10 |
| 33037572 | After active treatment, the patient ultimately achieved remission and was discharged from the hospital. | 2020-10-10 |
| 33037657 | Combining data from all European countries in one platform/study would provide a unique opportunity to monitor the incidence of COVID-19 in liver transplantation setting, adding a dynamic dimension to our first report, and most importantly to collect additional information on treatment strategies to optimize the management of COVID 19 in the very special population of LT recipients. | 2020-10-10 |
| 33037698 | The whole world is entangled by the coronavirus disease (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), people are dying in thousands each day, and without an actual medication, it seems not possible for the bringing this global health crisis to a stop. | 2020-10-10 |
| 33037895 | Delayed diagnostics and treatment increase the risk of permanent loss of vision. […] Current media reports have suggested that patients with medical emergencies delay seeking treatment out of fear of being infected with the corona virus SARS-CoV‑2. […] This study analyzed data from a German university hospital to determine if the coronavirus pandemic had an impact on treatment and visual outcomes of patients with retinal detachment. […] Medical treatment for retinal detachment was not influenced by the coronavirus pandemic. | 2020-10-10 |
| 33038012 | Our findings of correlations between alpha defensin and levels of IL-1Ra and IL-18, which were previously shown to be useful in COVID-19 treatment and follow-up, indicates that it may also be promising in treatment. | 2020-10-10 |
| 33038075 | Ensuring equitable treatment and support may be an important challenge ahead, considering the possible syndemic effect of social determinants of health. | 2020-10-10 |
| 33038075 | Ensuring equitable treatment and support may be an important challenge ahead, considering the possible syndemic effect of social determinants of health. | 2020-10-10 |
| 33038075 | Ensuring equitable treatment and support may be an important challenge ahead, considering the possible syndemic effect of social determinants of health. | 2020-10-10 |
| 33038075 | Ensuring equitable treatment and support may be an important challenge ahead, considering the possible syndemic effect of social determinants of health. | 2020-10-10 |
| 33038075 | Ensuring equitable treatment and support may be an important challenge ahead, considering the possible syndemic effect of social determinants of health. | 2020-10-10 |
| 33038075 | Ensuring equitable treatment and support may be an important challenge ahead, considering the possible syndemic effect of social determinants of health. | 2020-10-10 |
| 33038075 | Ensuring equitable treatment and support may be an important challenge ahead, considering the possible syndemic effect of social determinants of health. | 2020-10-10 |
| 33038075 | Ensuring equitable treatment and support may be an important challenge ahead, considering the possible syndemic effect of social determinants of health. | 2020-10-10 |
| 33038075 | Ensuring equitable treatment and support may be an important challenge ahead, considering the possible syndemic effect of social determinants of health. | 2020-10-10 |
| 33038075 | Ensuring equitable treatment and support may be an important challenge ahead, considering the possible syndemic effect of social determinants of health. | 2020-10-10 |
| 33038075 | Ensuring equitable treatment and support may be an important challenge ahead, considering the possible syndemic effect of social determinants of health. | 2020-10-10 |
| 33038075 | Ensuring equitable treatment and support may be an important challenge ahead, considering the possible syndemic effect of social determinants of health. | 2020-10-10 |
| 33038075 | Ensuring equitable treatment and support may be an important challenge ahead, considering the possible syndemic effect of social determinants of health. | 2020-10-10 |
| 33038075 | Ensuring equitable treatment and support may be an important challenge ahead, considering the possible syndemic effect of social determinants of health. | 2020-10-10 |
| 33038075 | Ensuring equitable treatment and support may be an important challenge ahead, considering the possible syndemic effect of social determinants of health. | 2020-10-10 |
| 33038075 | Ensuring equitable treatment and support may be an important challenge ahead, considering the possible syndemic effect of social determinants of health. | 2020-10-10 |
| 33038076 | Effective treatment of these severe cases remains a challenge due to a lack of early detection. | 2020-10-10 |
| 33038090 | The statement is not intended to address treatment, infection control principles, or public health issues related to SARS-CoV2. | 2020-10-10 |
| 33038227 | The efficacy of convalescent plasma (CP) for the treatment of COVID-19 remains unclear. […] In a matched cohort analysis of hospitalized patients with severe COVID-19, the impact of CP treatment on in-hospital mortality was evaluated using univariate and multivariate Cox proportional-hazards models, and the impact of CP treatment on time to hospital discharge was assessed using a stratified log-rank analysis. 64 patients who received CP a median of 7 days after symptom onset were compared to a matched control group of 177 patients. […] There was a signal for improved outcomes among the elderly, and further adequately powered randomized studies should target this subgroup when assessing the efficacy of CP treatment. | 2020-10-10 |
| 33038310 | A few weeks later, hospitals had to put in place a series of drastic measures to deal with the massive influx of suspected COVID-19 (COronaroVIrus Disease) patients while securing regular patient care, in particular in the intensive care units (ICU). […] Indeed, integrated into a steering committee created to organize the crisis in the intensive care units, the role of the clinical pharmacist was focused on the organization and coordination between ICU and the pharmacy, the implementation of actions to secure practices, to train new professionals and the adaptation of therapeutic strategies. | 2020-10-10 |
| 33038341 | Immediate oncological outcomes did not differ significantly between groups (R0 resection 99%, nodal upstaging 14%, adjuvant treatment 29%). […] During the COVID-19 pandemic, surgical treatment of NSCLC was associated with a rate of postoperative COVID-19 of 5% with a significant impact on readmissions but not on other outcomes studied. | 2020-10-10 |
| 33038418 | Several therapeutic targets and treatment strategies have also been provided in an attempt to tackle COVID-19 complications. | 2020-10-10 |
| 33038433 | Drug repurposing has been used to rapidly identify potential treatment for COVID-19, which could move quickly to phase-3. | 2020-10-10 |
| 33038435 | This translated to an increase in COVID-19 treatment capacity of 3,028 bed hours and 7,500 less patient interactions that required consumption of personal protective equipment per week. | 2020-10-10 |
| 33038452 | Currently, no targeted therapy exists, and since the number of infections and death toll keeps rising, it has become a necessity to study possible therapeutic targets. | 2020-10-10 |
| 33038592 | The multivariate analysis showed that asthma, COPD, ICS treatment and OCS treatment were not independent risk factors for ICU admission or death. | 2020-10-10 |
| 33038863 | Treatment with immune-checkpoint inhibitors (ICIs) has shown efficacy against a variety of cancer types. […] In COVID-19 pneumonia, ICI administration may lead to exacerbation; however, it is also possible that ICI may be used for the treatment of COVID-19. […] It has also been shown that ICI has potential in the treatment of intractable filamentous fungal infections. | 2020-10-10 |
| 33038878 | In the case of people with dementia, the compliance with sanitary recommendations and the necessary physical isolation can have far-reaching negative consequences in terms of limiting the continuation of tailored care, support and treatment. | 2020-10-10 |
| 33038909 | Therefore, the use of general antiviral drugs is at the first line of treatment, though complicated with limited effectiveness and systemic side effects. | 2020-10-11 |
| 33038926 | We analysed the results of 34 indicators of the Healthcare quality standard (EQA), comprising different types: treatment (4), follow-up (5), control (10), screening (7), vaccinations (4) and quaternary prevention (4). | 2020-10-11 |
| 33038939 | Interleukin-6 (IL-6) has emerged as a key component of the immune response to SARS-CoV-2, such that the repurposing of anti-IL-6 therapeutics for COVID-19 is now a major line of investigation, with several ongoing clinical trials. | 2020-10-11 |
| 33039110 | In the deep vein thrombosis group, 9 (28%) patients died from major organ failure, despite aggressive medical therapy. […] In patients with simple arterial thrombosis and those with deep vein thrombosis, we observed a decrease in inflammatory parameters (C-reactive protein) and in D-dimer and fibrinogen after aggressive therapy (P <.001> | 2020-10-11 | </.001>
| 33039120 | This study sought to analyse the association of severe forms of COVID-19 and mortality with hypertension and a previous treatment with ACEI and ARB. […] Hypertension (55.1% vs 36.7%, P<0.001) and antihypertensive treatment were associated with severe COVID-19 and mortality. […] The association between ACEI/ARB treatment and COVID-19 severity criteria found in univariate analysis (Odds Ratio 1.74, 95%CI [1.14-2.64], P=0.01) was not confirmed when adjusted on age, gender, and hypertension (adjusted OR1.13 [0.59-2.15], P=0.72). […] This study suggests that previous treatment with ACEI and ARB is not associated with hospital mortality, 1- and 2-month mortality, and severity criteria in patients hospitalised for COVID-19. | 2020-10-11 |
| 33039144 | Immunosuppressive therapy with tacrolimus and mycophenolate mofetil was continued throughout the course of infection. […] Oxygen therapy was given for a single night, and the patient gradually recovered with supportive care only. […] Withdrawal of immunosuppressive therapy could be associated with higher mortality. | 2020-10-11 |
| 33039218 | Better understanding and awareness of these symptoms can lead to more efficient diagnosis, rapid treatment, isolation, and decreased spread of the disease. | 2020-10-11 |
| 33039221 | To explore the effect of COVID-19 outbreak on the treatment time of patients with ST-segment elevation myocardial infarction (STEMI) in Hangzhou, China. […] The pre-hospital and in-hospital treatment times of STEMI patients during the COVID-19 epidemic were longer than those before the epidemic. […] Cumulative mortality was showed in Kaplan-Meier survival curves after the surgery in the 2020 group was significantly different higher than the 2019 group during the 28 days.The diagnosis and treatment process of STEMI patients during an epidemic should be optimized to improve their prognosis. | 2020-10-11 |
| 33039230 | In this era of pandemic, it is very important for the physicians to be aware of association of GBS with Covid-19, as early diagnosis and treatment of this complication could have gratifying results. | 2020-10-11 |
| 33039259 | In the absence of an effective vaccine and/or treatment, COVID-19 remains pandemic. | 2020-10-11 |
| 33039301 | Recognising the potential strain on intensive care units (ICUs), particularly on staffing, a working group was formed for the purpose of developing recommendations to support decision-making during rapid service expansion. | 2020-10-11 |
| 33039307 | Our response to the COVID-19 response was uniquely far reaching, with our department being given responsibility of an entire 36 bed medical COVID-19 ward in addition to our commitment to specialty-specific work, and saw half of our work force re-deployed to Intensive Treatment Unit (ITU). | 2020-10-11 |
| 33039545 | The secondary outcomes included pulmonary embolism, in-hospital mortality, admission to the intensive care unit, and antithrombotic therapy. […] The duplex ultrasound findings had a significant impact on the antithrombotic plan; 42 patients (72%) with COVID-19 in the DVT group had their therapy escalated and 49 (38%) and 3 (2%) had their therapy escalated and deescalated in the non-DVT group, respectively (P < .001). […] Duplex ultrasonography should be reserved for patients with a high clinical suspicion of venous thromboembolism for whom anticoagulation therapy could result in life-threatening consequences. | 2020-10-11 |
| 33039571 | Conservative management constitutes the most common method of treatment; however, little is known about the aesthetic, and functional morbidity related to either surgical or non-surgical treatments. | 2020-10-11 |
| 33039765 | Our clinical and treatment approach with differential diagnosis are discussed in this hitherto unreported obstetric emergency with COVID-19. | 2020-10-11 |
| 33039766 | The survey items included emergency response system characteristics, number of patients with stroke hospitalized within 7 days of onset, administered treatment types (IV rt-PA, mechanical thrombectomy, surgery, and endovascular therapy), and stroke patients with confirmed COVID-19. | 2020-10-11 |
| 33039922 | In this review, the available data on wastewater treatment, sanitation status and healthcare infrastructure from middle- and low-income countries is collected and correlated with the risk associated with the fecal-oral transmission of SARS-CoV-2. | 2020-10-11 |
| 33039952 | We hypothesized that fewer patients administered this combination would require oxygen therapy, intensive care support, or a combination of both than those who did not. […] After this date, patients were administered 1000 IU/d oral vitamin D3, 150 mg/d oral magnesium, and 500 mcg/d oral vitamin B12 upon admission if they did not require oxygen therapy. […] Primary outcome was deterioration leading to any form of oxygen therapy, intensive care support, or both. […] Fewer treated patients than controls required initiation of oxygen therapy during hospitalization (17.6 vs 61.5%, P = 0.006). […] DMB exposure was associated with odds ratios of 0.13 (95% confidence interval [CI], 0.03-0.59) and 0.20 (95% CI, 0.04-0.93) for oxygen therapy, intensive care support, or both on univariate and multivariate analyses, respectively. | 2020-10-11 |
| 33040021 | Procedures classified as aerosol-generating or possibly aerosol-generating by ≥90% of documents included autopsy, surgery/postmortem procedures with high-speed devices, intubation and extubation procedures, bronchoscopy, sputum induction, manual ventilation, airway suctioning, cardiopulmonary resuscitation, tracheostomy and tracheostomy procedures, non-invasive ventilation, high-flow oxygen therapy, breaking closed ventilation systems, nebulised or aerosol therapy, and high frequency oscillatory ventilation. | 2020-10-11 |
| 33040042 | With many regions suspending the provision of non-essential healthcare services, there is a risk that patients with common treatable illnesses do not receive prompt treatment, leading to more serious and complex presentations at a later date. | 2020-10-11 |
| 33040189 | Overall, cancer patients with SARS-CoV-2 had unique clinical features, and the established online tool could guide clinicians to predict the prognosis of patients during the COVID-19 epidemic and to develop more rational treatment strategies for cancer patients. | 2020-10-11 |
| 33040241 | In addition, the cardiovascular complications of COVID-19 including acute myocardial injury, thromboembolism, cardiomyopathy, myocarditis, and pericardial disease overlap with many of those encountered during cancer treatment. […] This has implications for cardiac monitoring, chemotherapy administration, and the diagnosis and treatment of cardiovascular disease during COVID-19. | 2020-10-11 |
| 33040252 | This drug demonstrated its effectiveness, as patients recovered successfully with this treatment without the necessity of attending a hospital to use mechanical ventilation. | 2020-10-11 |
| 33040272 | Therefore, more attention should be paid to the treatment of comorbidities and complications in elderly patients. | 2020-10-11 |
| 33040384 | In conclusion, the detection and serial monitoring of this subset of inflammatory monocytes using flow cytometry could be of great help in guiding the prognostication and treatment of patients with COVID-19 and merits further evaluation. | 2020-10-11 |
| 33040443 | No treatment for novel coronavirus disease has yet been developed; thus, countermeasures to prevent the spread of coronavirus disease in dialysis facilities must be rapidly established. | 2020-10-11 |
| 33040594 | An increasing number of preclinical and clinical investigations of stem cell and derivatives therapy for COVID-19 were being carried out, among which several studies have preliminarily demonstrated the safety and possible efficacy of stem cell transplantation therapy, providing a hint to solve the tricky situation of anti-COVID-19. | 2020-10-12 |
| 33040749 | After 5 treatment cycles, no adverse effects were detected on filtration efficiency, structural integrity, or strap elasticity. | 2020-10-12 |
| 33040759 | Further, higher levels of loneliness increased the risk of depression symptoms almost four-fold in caregivers, OR = 3.85 (95% 95% CI 3.08-4.85, P < 0.001), whereas accessing therapy attenuated the risk of depression (43%). | 2020-10-12 |
| 33040763 | Orderly and efficient nursing management during COVID-19 treatment is very important to ensure the quality of clinical nursing, improve the cure rate and avoid the infection of nurses. […] This practical experience of the establishment and management of the nursing unit can provide reference for the nursing management of other public health events, such as the treatment of infectious diseases. | 2020-10-12 |
| 33040768 | Our purpose was to determine the intensive care units’ (ICUs) medical staff surge capacity during the Covid-19 outbreak in spring 2020 in Spain. | 2020-10-12 |
| 33040779 | Due to the lack of specific treatment protocols for patients and the use of supportive treatments based on meeting the nutritional needs for all patients, blood albumin levels and nutritional status of patients were also evaluated using Subjective Global Assessment (SGA) Form. | 2020-10-12 |
| 33041058 | There has been a variety of potential treatment modalities for the various forms of illness ranging from asymptomatic carriers to the ventilated ICU patients. […] Cytosorbents® cytokine filter is a potential treatment methodology aimed at reducing the cytokine storm, thus serving as a bridge for therapy in the acutely ill patients infected with COVID-19. […] The following case report demonstrates the utility in a critically ill patient who survived the cytokine storm after receiving the cytokine filter via continuous renal replacement therapy bridging him to further definitive therapy. | 2020-10-12 |
| 33041077 | The most common treatment was reduction or removal of antimetabolite (77.8%). […] Future studies are needed to determine optimal approach to treatment and management of immunosuppression in kidney transplant recipients with COVID-19 infection. | 2020-10-12 |
| 33041111 | The following keywords were used: ((COVID-19) OR (SARS-CoV-2)) AND ((((((therapeutics) OR (treatment)) OR (vaccine)) OR (hydroxychloroquine)) OR (antiviral)) OR (prognosis)). […] The following pharmacologic therapies were evaluated: chloroquine (CQ), hydroxychloroquine (HCQ), antivirals therapies, plasma therapy, anti-inflammatories, and a vaccine. […] According to level 1 evidence reviewed here, the most effective SARS-Co-V-2 pharmacologic treatments include remdesivir for mild to severe disease, and a triple regimen therapy consisting of lopinavir-ritonavir, ribavirin and interferon beta-1b for mild to moderate disease. | 2020-10-12 |
| 33041130 | Determining the factors affecting the mortality and clinical conditions of the patients with Covid-19 are indispensable needs in developing patient treatment algorithms. | 2020-10-12 |
| 33041141 | While treatment priorities and goals are identical to pre-pandemic approaches, the management of COVID-19 patients in cardiac arrest has distinct differences from cardiac arrest patients without COVID-19. | 2020-10-12 |
| 33041191 | However, the presence of fungal markers in clinically relevant specimens, with the exception of bronchopulmonary colonization by Candida, should make it advisable to early implement antifungal therapy. | 2020-10-12 |
| 33041195 | CT-measured cardiac indices might have predictive value regarding survival and extent of lung involvement in hospitalized patients with COVID-19 and could possibly be used for the risk stratification of these patients and for guiding therapy decision-making. | 2020-10-12 |
| 33041212 | We also propose ways of adopting antibody-based strategies - such as cocktail antibody therapeutics against SARS-CoV-2 - to overcome the possible resistance of currently identified mutants and mitigate possible antibody-dependent enhancement (ADE) pathologies. | 2020-10-12 |
| 33041213 | Enhanced testing has been put forward as a means to reduce transmission while awaiting the development of targeted therapy or effective vaccination. | 2020-10-12 |
| 33041350 | By virtual screening, molecular docking and molecular dynamics techniques, we have established a strong inhibitory possibility of choline for SARS 3CLpro protease which may provide a lead for prenatal COVID-19 treatment. | 2020-10-12 |
| 33041362 | We conducted a survey to study the changes in the clubfoot treatment practices, Achilles tenotomy methods, and the role along with the possible impact of teleconsultation during this pandemic. […] The COVID-19 pandemic has significantly impacted clubfoot treatment practices during the lockdown period in India. | 2020-10-12 |
| 33041508 | During treatment, 13 patients deteriorated and required further treatment for supporting organ function. | 2020-10-12 |
| 33041620 | The purpose of this paper is to comprehensively evaluate secondary causes of inflammatory myopathies (myositis) and to review treatment options. […] We also discuss treatment for malignancy-associated myositis and overlap myositis, thought to be a separate entity from other rheumatologic diseases. […] Infections, drugs, rheumatologic diseases, and malignancies are important causes of myositis and are important to diagnose as they may have specific therapies beyond immunomodulatory therapy. | 2020-10-12 |
| 33041632 | Those parameters are meaningful not only to alert on some increase of the infection, but also to assess the efficiency of the therapy and health policy. | 2020-10-12 |
| 33041706 | As the novel infection with SARS-CoV-2 emerges, objective assessment of the scientific plausibility of nutraceutical and botanical interventions for prevention and treatment is important. | 2020-10-12 |
| 33041712 | Very few children are likely to develop severe disease.Supportive care is the mainstay of treatment. | 2020-10-12 |
| 33041797 | Besides, the key targets and pathways may reveal the main pharmacological mechanism of Astragaloside IV in the treatment of COVID-19. | 2020-10-12 |
| 33041811 | We collected and analyzed the putative effect of the 16 most common co-morbidities, previous treatment with 33 drug classes, symptoms, radiological, and laboratory findings at admission and drug therapy after admission. | 2020-10-12 |
| 33041814 | The COVID-19 pandemic represents an unprecedented challenge for the researchers to offer safe, tolerable, and effective treatment strategies for its causative agent known as SARS-CoV-2. […] The effectiveness of the controversial treatment options for COVID-19 such as nonsteroidal antiinflammatory drugs, angiotensin 2 conversion enzyme inhibitors and selective angiotensin receptor blockers was also discussed. […] A systemic search in the PubMed, Science Direct, LitCovid, Chinese Clinical Trial Registry, and ClinicalTrials.gov data bases was conducted using the keywords “coronavirus drug therapy,” passive immunotherapy for COVID-19’, “convalescent plasma therapy,” (CPT) “drugs for COVID-19 treatment,” “SARS-CoV-2,” “COVID-19,” “2019-nCoV,” “coronavirus immunology,” “microbiology,” “virology,” and individual drug names. | 2020-10-12 |
| 33041824 | Major efforts are focused on optimizing mechanical ventilation, antiviral, and supportive treatment; however, the role of heparin and low molecular weight (LMW) heparin in this setting has been largely overlooked. […] This review summarizes the available evidence about the role of heparan sulfate as a key entry mechanism for SARS-CoV-2; the efficacy of heparin and LMW heparin in counteracting its entry into the cell, the recent experimental findings obtained in in vitro studies using the LMW heparin enoxaparin Inhixa®, the role of heparin and LMW heparin in modulating the cytokine storm, and the evidence for the use of LMW heparin in the prevention and treatment of the thromboembolic complications of COVID-19. […] The available evidence suggests that LMW heparin appears as a promising tool in the treatment of COVID-19. | 2020-10-12 |
| 33041827 | In this study, we investigated ShenFuHuang formula (SFH), a traditional Chinese medicine, which has been widely used as complementary therapy for clinical treatment of COVID-19 in Wuhan, to understand its pharmacological properties. […] Results showed that SFH treatment significantly inhibited the inflammatory damage by reducing the generation of neutrophils in Poly (I:C)-induced viral infection model. […] Moreover, SFH treatment could improve the phagocytosis of macrophages and enhance the expression of immune genes in an immune deficiency model. […] Furthermore, SFH treatment exhibited promising anti-thrombosis effect in a thrombus model. | 2020-10-12 |
| 33041830 | In absence of clinically proven treatment guidelines, several repurposed drugs and investigational agents are currently being evaluated in clinical trials for their probable benefits in the treatment of COVID-19. […] Moreover, there is a need to clearly define the patient populations who warrant therapy and also the timing of initiation of treatment. […] This review explains the pathophysiology of COVID-19 and summarizes the potential treatment candidates, which can provide guidance in developing effective therapeutic strategies. | 2020-10-12 |
| 33042116 | There is potential use of T cell depleting therapies and possibly anti-CD20 therapy for COVID-19 and clinical research using these medications is warranted. | 2020-10-12 |
| 33042151 | The pandemic of Coronavirus Disease 2019 (COVID-19) caused by SARS-CoV-2 has induced global eagerness to develop vaccines and therapeutics for treating COVID-19, including neutralizing antibodies. […] The large interaction surface with strong affinity between SARS-CoV-2 and hACE2 (dG-12.4) poses a huge challenge to develop reliable antibody therapy that truly blocks SARS-CoV-2 adherence and infection. | 2020-10-12 |
| 33042210 | Studies are ongoing for the diagnosis and treatment of this disease, which is defined as a pandemic. | 2020-10-12 |
| 33042442 | We aim to develop a better understanding of how ALI/ARDS occurs and improve ALI/ARDS therapy. | 2020-10-12 |
| 33042494 | As with all respiratory viruses, public health measures are focused on contact tracing, isolation, and treatment of affected individuals, who have respiratory symptoms. | 2020-10-12 |
| 33042532 | The purpose of this study was to review these coronaviruses, especially SARS (because of its very similar gene sequence to the 2019-nCoV or SARS-CoV-2), from the perspective of appropriate approaches to food production technology, including following good food safety practices in food production lines; avoidance of underheating in the processing of swine and the other meat products; uncertainty about the safety of frozen or refrigerated meat products; providing unfavorable environmental conditions for coronavirus survival (minimum heat treatment, e.g., low-temperature long time and greater for liquid food products, pH ≤ 3, minimum storage relative humidity); production of industrial foods fortified and enriched with vitamin D, C, B3, K, amino acid L-tryptophan, nicotinamide adenine dinucleotide (NAD+), and tannins; and preventing the production of industrial foods fortified or enriched with mineral supplements that participate in the Fenton reaction in the human body. | 2020-10-12 |
| 33042541 | Most of us also have very restricted access to central sites of the crisis, as intensive care units, nursing homes, meat packing plants and prisons are often not available for photographic representation. | 2020-10-12 |
| 33042544 | The combination therapy of Lopinavir/Ritonavir plus Favipiravir might be a treatment option for patients with COVID-19. | 2020-10-12 |
| 33042552 | We searched PubMed, Cochrane, EmBase, Google Scholar, and Google for all reports on hydroxychloroquine as a treatment for COVID-19 patients. | 2020-10-12 |
| 33042560 | During ECMO support, occlusive circuit thrombosis developed despite systemic anticoagulation therapy with heparin. […] He was subsequently administered combination therapy with nafamostat and heparin. […] Although the combination therapy could prevent circuit thrombosis, it was converted to heparin monotherapy because of hyperkalemia and hemothorax. […] Combination therapy with nafamostat and heparin can prevent circuit thrombosis during ECMO. […] However, bleeding can still develop with this combination therapy during ECMO. | 2020-10-12 |
| 33042586 | In this expert opinion, the authors canvas the many challenges in the diagnosis, treatment and delivery of care to patients with congestive heart failure and acute coronary syndromes during the COVID-19 pandemic. | 2020-10-12 |
| 33042589 | Emerging clinical data has revealed that severe COVID-19 disease is associated with heightened inflammatory responses and a procoagulant state, suggesting that patient treatment strategies must extend beyond antiviral agents. […] Effective approaches to the treatment of vulnerable patients with comorbidities will render COVID-19 substantially more manageable. | 2020-10-12 |
| 33042591 | The focus on developing a vaccine for SARS-CoV-2 and the treatment of COVID-19 is, in fact, disrupting many upcoming and/or ongoing clinical trials on other diseases around the globe. | 2020-10-12 |
| 33042702 | While research is focusing on epidemiology, transmission, vaccine development, and therapeutics for coronavirus disease 2019 (COVID-19), there is a possibility of disease relapse. | 2020-10-12 |
| 33042803 | This article was committed to studying the influence of gynecological tumor treatment history compared to the Coronavirus Disease 2019 (COVID-19), which was of great significance for the treatment of gynecological cancer patients during the outbreak of COVID-19. […] We retrospectively analyzed the diagnosis and treatment of six gynecological cancer patients infected with SARS-CoV-2 in Tongji Hospital in Wuhan from January 30 to March 25, 2020. […] To better explain the treatment of gynecological cancer patients during the epidemic of COVID-19, we summarized the case characteristics, auxiliary examination, treatment plan, and outcome of these six patients. […] Also, due to the influence of cancer treatment history, COVID-19-related atypical symptoms became the first symptom of COVID-19 in some cases, which increased the difficulty of diagnosis. […] Furthermore, in terms of treatment for these cases, immune boosters and reagents that raised white blood cells were applied, except for in symptomatic antiviral treatment. […] After cancer-related treatment, the gynecological cancer patients became more susceptible to COVID-19. […] Besides, the history of cancer treatment made the diagnosis of COVID-19 difficult, which also affected the treatment of COVID-19. […] Therefore, we put forward the corresponding therapy suggestions for gynecological cancer patients during the outbreak of COVID-19. | 2020-10-12 |
| 33042826 | In our series, hospitalization rate was 74%, 39% of patients developed acute respiratory distress syndrome (ARDS), and the case-fatality rate was 35% (8/23). 87% of patients received anti-viral treatment (87% hydroxychloroquine, 74% lopinavir/ritonavir, 13% azithromycin), 43% corticosteroids, 26% interferon-β, 4% tocilizumab, and 82% of hospitalized patients received anticoagulation. […] In patients with lung cancer receiving systemic therapy (n = 242) incidence and mortality from COVID-19 were 4.5, and 2.1%, respectively, with no differences found by type of treatment. […] Although larger series are needed, no differences in mortality were found by type of cancer treatment. | 2020-10-12 |
| 33042873 | Methods: We collected the clinical data of 24 patients with moderate-to-severe COVID-19 who were admitted to the isolation ward of the First Affiliated Hospital of Bengbu Medical College from January, 2020 to February 20, 2020, and evaluated the data of clinical characteristics, blood test results, inflammatory index, chest CT imaging characteristics, and antiviral treatment, comparing this with the clinical data of 41 patients with moderate condition in the same period. […] (5) Clinical antiviral treatment: There was no statistically significant difference in the combination of two or three antiviral drugs between the two groups (χ2 = 0.05, P > 0.05). | 2020-10-12 |
| 33042941 | Objective: Focusing on these aspects, this manuscript reviews public awareness about COVID-19, myths surrounding it, its symptoms, treatment, transmission, importance of information sources, types of information to be considered in awareness campaigns, promotional channels, and their implications in Saudi Arabia. […] Results: Awareness levels of the participants related to COVID-19, its means of transmission, preventive measures, symptoms, and treatment were identified to be moderate to high (60-80%). | 2020-10-12 |
| 33042994 | We also discuss ongoing clinical trials and treatment based on RAS cascade intervention. | 2020-10-12 |
| 33043030 | The urgency for an effective therapy is justified by the easy and fast viral transmission and the high number of patients with severe respiratory distress syndrome who have increasingly occupied intensive care hospital beds, leading to a collapse in health systems in several countries. […] However, to date, there is no sufficient evidence of the effectiveness of any researched therapy. […] In order to guide decision-making for the treatment of COVID-19, this review aims to present studies and guidelines on the main therapies that have been and are currently being tested against SARS-CoV-2 and to critically analyze the reported evidences. | 2020-10-12 |
| 33043032 | As therapeutic interventions in the early phase of the disease are attracting more and more interest, we argue that now is the time to involve patients’ organizations in the design of clinical protocols in order to define the most relevant end-points and assess the risk-benefit balance of new therapies. | 2020-10-12 |
| 33043036 | While there was a 4.8% (1/21) false negative rate for the PK- and DTT-treated sputum, neither treatment showed any false positive cases among patients with non-COVID diseases. | 2020-10-12 |
| 33043063 | Quantifying the role of CDC risk factors upon admission may improve risk stratification and identification of patients who may require closer monitoring and more intensive treatment. | 2020-10-12 |
| 33043128 | The lung targeting is selective with no increase in uptake into the brain or the heart where the side-effects of theophylline are treatment-limiting. | 2020-10-12 |
| 33043132 | Low level laser therapy (LLLT) has significant anti-inflammatory effects and reduces inflammatory cytokines. […] Prior to treatment, oxygen saturation (SpO2) via pulse oximetry was 88%-93% on 5-6 L oxygen. […] Post-treatment, the patient noted appreciable improvement in respiratory symptoms. […] This report suggests that adjunct LLLT can be safely combined with conventional treatment in patients with severe COVID-19 and morbid obesity. | 2020-10-12 |
| 33043142 | All the patients were given antiviral and antihypertension treatment, of which 14 patients were treated with RASI and 13 patients without RASI. | 2020-10-12 |
| 33043163 | From December 2019 to May 22, 2020 the emerging and ever-increasing pandemic of coronavirus 19 (COVID-19) had no effective and safe treatment. | 2020-10-12 |
| 33043164 | Tocilizumab, an IL-6 receptor antagonist, was suggested as a possible treatment of severe or critical COVID-19 pneumonia in a small Chinese study. […] The TOCIVID-19 trial evaluates efficacy and tolerability of tocilizumab in the treatment of patients with severe or critical COVID-19 pneumonia. | 2020-10-12 |
| 33043235 | With these observations in mind, we postulate as to the potential therapeutic role of FXa inhibitors as a prophylactic and therapeutic treatment for high-risk patients with COVID-19. | 2020-10-12 |
| 33043250 | She continued taking hydroxyurea and aspirin for her treatment of polycythemia vera. | 2020-10-12 |
| 33043272 | It then evaluates the role of machine learning, including predictive analytics and random forest modeling, to help clinicians assess patients’ risk of developing active infection and devise a comprehensive approach to prevention and treatment. | 2020-10-12 |
| 33043280 | Pharmacists are medication experts providing patient care in a variety of settings including hospitals, clinics, community pharmacies, long-term care, physician offices, and national and public health. | 2020-10-12 |
| 33043282 | Among them, an anti-parasitic drug, diminazene, showed the highest inhibition effects on furin with an IC50 of 5.42 ± 0.11 μM, which might be used for the treatment of COVID-19. | 2020-10-12 |
| 33043284 | At 19 days median follow-up, 89·7% of medical inpatients significantly improved (46·1% after 24 h, 61·5% after 3 days), 70·6% were discharged from the hospital and 85·7% no longer needed oxygen therapy. […] IL-6R inhibition appears to be a potential treatment strategy for severe SARS-CoV-2 pneumonia and intravenous Sarilumab seems a promising treatment approach showing, in the short term, an important clinical outcome and good safety. | 2020-10-12 |
| 33043287 | At the adjusted analysis enoxaparin was associated with lower in-hospital mortality (Odds Ratio 0·53, 95% C.I. 0·40-0·70) compared with no enoxaparin treatment. […] Enoxaparin treatment was associated with reduced risk of intensive care admission at the adjusted analysis (Odds Ratio 0·48, 95% C.I. […] This study shows that treatment with enoxaparin during hospital stay is associated with a lower death rate and, while results from randomized clinical trials are still pending, this study supports the use of thromboprophylaxis with enoxaparin in all patients admitted for COVID-19. | 2020-10-12 |
| 33043312 | March through May 2020, a model of novel coronavirus (COVID-19) disease progression and treatment was constructed for the open-source Synthea patient simulation. | 2020-10-12 |
| 33043313 | In this multicenter retrospective cohort study, we analyzed clinical characteristics, medical history, laboratory tests, and treatment data of 12,413 COVID-19 patients. | 2020-10-12 |
| 33043320 | Ibrutinib, a known Burton’s tyrosine kinase (BTK) and interleukin-2 inducible T-cell kinase (ITK) inhibitor, is used for the treatment of B-cell disorders (chronic lymphocytic leukemia [CLL] and various other lymphomas) and chronic graft versus host disease following allogeneic hematopoietic cell transplantation. | 2020-10-12 |
| 33043453 | A number of treatment approaches have been trialled, each with its inherent unique challenges. […] This rapid systematic review aimed to examine the current incidence and available treatment of arrhythmias in COVID-19, as well as barriers to implementation. […] Drug-induced long QT syndrome secondary to antimalarial and antimicrobial therapy was a significant contributor to arrhythmia formation, with an incidence of 14.15%. […] Treatment strategies aim to minimise this through risk stratification and regular monitoring of corrected QT interval (QTc). […] Drug therapy is pro-arrhythmogenic and may result in TdP and SCD in these patients. […] Risk assessment and regular QTc monitoring are imperative for safety during the treatment course. | 2020-10-12 |
| 33043651 | The disturbance in the international normalized ratio (INR) in patients receiving warfarin therapy is of concern. […] We aimed to evaluate coagulation features in hospitalized patients under warfarin treatment for prosthetic heart valves during the novel coronavirus disease 2019 (COVID-19) pneumonia pandemic. […] Between 20 February and 28 March 2020, 10 patients (7 males) who were under warfarin therapy for prosthetic heart valves were hospitalized after a diagnosis of COVID-19 in Tehran Heart Center, Tehran, Iran. […] All the patients received antiviral treatment, either lopinavir/ritonavir or oseltamivir. […] Antiviral therapy in patients with COVID-19 with prosthetic heart valves might be an issue responsible for an uncontrolled INR. […] Bridging in these patients during the antiviral treatment might be required and because of significant INR fluctuations, it might be safer to prescribe antiviral treatment in an inpatient setting. | 2020-10-12 |
| 33043740 | In the review, a comprehensive analysis of the recent developments of the COVID-19 pandemic has been provided, including the structural characterization of the virus, the current worldwide status of the disease, various detection strategies, drugs recommended for the effective treatment, and progress of vaccine development programs by different countries. […] They target different approaches, including repurposing the already approved diagnosis and treatment options for similar CoVs. | 2020-10-12 |
| 33043784 | To identify therapeutics that can be repurposed as SARS-CoV-2 antivirals, we developed and initiated a high-throughput cell-based screen that incorporates the essential viral papain-like protease (PLpro) and its peptide cleavage site into a luciferase complementation assay to evaluate the efficacy of known drugs encompassing approximately 15,000 clinical-stage or US Food and Drug Administration (FDA)-approved small molecules. | 2020-10-12 |
| 33043977 | Fear of contracting COVID-19 and medication adherence were both high and unrelated. […] Type of medication was not linked to these outcomes. […] The COVID-19 pandemic does not seem to be affecting adherence to medication but seems to present relevant effects on psychological well-being. | 2020-10-12 |
| 33044166 | With the pandemic spreading at such an alarming rate, a lot of efforts are in the process of identification of an effective treatment at it’s earliest. | 2020-10-12 |
| 33044282 | In univariable analysis, body mass index, hyperferritinemia, high C-reactive protein, Pediatric Index of Mortality 3 score, vasoactive medication, and invasive mechanical ventilation were associated with severe acute kidney injury. | 2020-10-12 |
| 33044314 | To answer our research questions, we analyzed two samples because not all PROMs were sent to participants at the same time points after treatment. […] The first sample consisted of all participants who completed PROMs on quality of life (QoL), pain, and hand function at their final follow-up time point, which was either 3, 6, or 12 months post-treatment. […] The second sample consisted of participants who completed PROMs 3 months post-treatment on anxiety, depression, and illness perception. | 2020-10-12 |
| 33044373 | Bandage contact lens removal and appropriate treatment resulted in improvement of the visual acuity and prevented the spread of fungus to the underlying ocular structures. | 2020-10-12 |
| 33044493 | Newborns were admitted to well-baby nurseries (WBNs) (82 infants) and neonatal intensive care units (NICUs) (19 infants) in 2 affiliate hospitals at a large academic medical center in New York, New York. | 2020-10-12 |
| 33044601 | In the fight against epidemic infectious diseases in the past 2,000 years, Chinese medicine (CM) has gradually developed a complete response system including diagnosis and treatment. […] The focal point of CM in the treatment of infectious diseases is the personalized response state to pathogen, which is a treatment method consistent with the personalized concept of precision medicine. […] Compared with the methods of directly killing or inactivating pathogens, which are used in modern medicine, CM is an effective treatment modality that has a wider range of points of action in the human body. […] This article discusses the different treatment mechanisms for infectious diseases in CM and modern medicine and the advantages of CM methods, which will reacquaint the world with CM. […] The improvement of the diagnosis and treatment system of CM based on scientific concepts and methods and the organic combination of both treatment methods of modern medicine and CM will provide the best solution for humans to defeat epidemic infectious diseases. | 2020-10-12 |
| 33044747 | Convalescent plasma and hyperimmune immunoglobulin may reduce mortality in patients with viral respiratory diseases, and are currently being investigated in trials as potential therapy for coronavirus disease 2019 (COVID-19). […] OBJECTIVES: To continually assess, as more evidence becomes available, whether convalescent plasma or hyperimmune immunoglobulin transfusion is effective and safe in treatment of people with COVID-19. […] Control groups received standard care at time of treatment without convalescent plasma. […] We are very uncertain whether convalescent plasma therapy affects the risk of moderate to severe AEs (very low-certainty evidence). 17 studies (35,944 participants) assessed SAEs for 20,622 of its participants. […] We are uncertain whether convalescent plasma therapy results in a clinically relevant increased risk of SAEs (low-certainty evidence). […] There was limited information regarding grade 3 and 4 AEs to determine the effect of convalescent plasma therapy on clinically relevant SAEs. […] In the absence of a control group, we are unable to assess the relative safety of convalescent plasma therapy. | 2020-10-12 |
| 33044760 | In one side, both the autoimmune diseases and immunosuppressive drugs increase the risk of infection due to impairment in the immune system and on the other side, postponing of MS treatment has serious consequences on the central nervous system (CNS). | 2020-10-12 |
| 33045049 | Most malaria-endemic countries run well-entrenched malaria control programs via their established frameworks for diagnosis, case management, treatment and overall surveillance. | 2020-10-12 |
| 33045077 | The limited impact of treatments for COVID-19 has stimulated several phase 1 clinical trials of whole-lung low-dose radiation therapy (LDRT; 0.3-1.5 Gy) that are now progressing to phase 2 randomized trials worldwide. […] Without refuting or endorsing LDRT as a treatment for COVID-19, the purpose of the workshop and this review is to provide guidance to clinicians and researchers who plan to conduct preclinical and clinical studies, given the limited available evidence on its safety and efficacy. | 2020-10-12 |
| 33045350 | Knowing the ability of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) to bind to the angiotensin-converting enzyme 2 (ACE2) receptor and to enter cells via endocytosis paved the way for repositioning of old drugs as potential treatment of COVID-19, the disease caused by SARS-CoV-2 infection. | 2020-10-12 |
| 33045362 | There is no effective treatment of the disease, hence, scaling up testing for rapid diagnosis of SARS-CoV-2 infected patients and quarantine them from healthy individuals is one the best strategies to curb the pandemic. | 2020-10-12 |
| 33045402 | The proposed pragmatic trial will allow parallel testing of vitamin D3 supplementation for early treatment and post-exposure prophylaxis of COVID-19. | 2020-10-12 |
| 33045450 | In acute ischemic stroke treatment, the efficacy and safety of emergent carotid artery stenting (eCAS) for hyperacute ischemic stroke (hAIS) due to internal carotid artery stenosis (ICS) have not been sufficiently established. […] Recanalization was achieved successfully by eCAS, and dual antiplatelet therapy and argatroban were administrated following eCAS. […] This case report suggests that eCAS for hAIS due to ICS following intravenous alteplase can be an effective treatment, along with appropriate antiplatelet medication and management in select patients. […] During the COVID-19 pandemic, the LAMP assay for COVID-19 detection might be a suitable diagnostic strategy preceding stroke treatment because of the rapid turnaround time. | 2020-10-12 |
| 33045553 | Among these recommendations, careful monitoring of pharmacological treatment, reinforcing medication adherence, and surveillance of drug-drug interaction risk in cases where the patient is being treated for COVID-19 are of utmost importance. | 2020-10-12 |
| 33045577 | Scientists are trying to discover drugs as effective treatment for patients with COVID-19. […] Unfortunately, until now there has been no definitive and effective treatment for patients with COVID-19. […] Based on evidence of the Tocilizumab’s effect on the SARS COV 2, researchers hope this drug will make effective and promising treatment to improve lung tissue inflammation in patients with the fatal COVID-19 virus. | 2020-10-12 |
| 33045596 | Zinc and the combination with zinc ionophore have been reported in basic research and several clinical investigations as a potentially viable and economical preventive and therapeutic options for COVID-19 treatment. […] There is an urgent need for the development of inexpensive, safe, and effective therapeutics to prevent and treat these viral infections. […] Considering that hydroxychloroquine (HCQ), the most studied zinc ionophore drug for COVID-19, is linked to potentially serious side effects, we propose the implementation of hinokitiol as a zinc ionophore and anti-infective agent for the prevention and treatment of COVID-19 and other viral infections. | 2020-10-12 |
| 33045618 | A large proportion of patients with these conditions are treated with lipid lowering medication and questions regarding the safety of continuing lipid-lowering medication in patients infected with COVID-19 have arisen. […] There is no evidence currently that lipid lowering therapy is unsafe in patients with COVID-19 infection. […] Lipid-lowering therapy should not be interrupted because of the pandemic or in patients at increased risk of COVID-19 infection. | 2020-10-12 |
| 33045723 | Using a previously-calibrated dynamic HIV transmission model, we constructed three sets of scenarios for each city: (1) sustained current levels of HIV-related treatment and prevention services (status quo); (2) temporary disruptions in health services and changes in sexual and injection risk behaviours at discrete levels between 0%-50%; and (3) linked HIV and SARS-CoV-2 testing offered to 10%-90% of the adult population in addition to scenario (2). | 2020-10-12 |
| 33045970 | There are currently no approved vaccine and no particular antiviral treatment for coronavirus disease. […] An attractive approach for treating COVID-19 is cell therapy. […] Cell therapy aims to inject new and healthy stem cells into a patient’s body, to repair the damaged cells and tissues. […] Stem cell therapy is one of the most studied and important approaches in treatment of COVID-19 these days. | 2020-10-13 |
| 33046047 | Sudden exacerbations and respiratory failure are major causes of death in patients with severe coronavirus disease 2019(COVID-19) pneumonia, but indicators for the prediction and treatment of severe patients are still lacking. […] Our study also found that there was no obvious effect of hormone therapy in patients with severe COVID-19. […] The study also suggested that hormone treatment has no significant effect on COVID-19. | 2020-10-13 |
| 33046088 | After initial conservative treatment with chest drain, both patients had a recurrence of pneumothorax during COVI-19 disease, contralateral (patient 1) or ipsilateral (patient 2) and therefore underwent lung surgery with thoracoscopy and bullectomy. | 2020-10-13 |
| 33046113 | Renal replacement therapy (RRT) in combination with sequential extracorporeal blood purification therapies (EBP) might support renal function, attenuate systemic inflammation, and prevent or mitigate multiple organ dysfunctions in COVID-19. […] Median baseline IL-6 was 1230 pg/ml (IQR 895) and decreased overtime (p < 0.001 Kruskal-Wallis test) during the first 72 h of the treatment, with the most significant decrease in the first 24 h (p = 0.001). […] Median baseline SOFA was 13 (IQR 6) and decreased significantly overtime (p < 0.001 at Kruskal-Wallis test) during the first 72 h of the treatment, with the most significant decrease in the first 48 h (median 8 IQR 5, p = 0.001). […] Compared to the expected mortality rates, as calculated by APACHE IV, the mean observed rates were 8.3% lower after treatment. […] No electrolyte disorders, catheter displacement, circuit disconnection, unexpected bleeding, air, or thromboembolisms due to venous cannulation of EBP were recorded during the treatment. […] During the treatment, patients experienced serum IL-6 level reduction, attenuation of systemic inflammation, multiorgan dysfunction improvement, and reduction in expected ICU mortality rate. | 2020-10-13 |
| 33046268 | I recommend also developing new SARS-CoV2 therapies based on the use of HLA-G and HLA-E or their specific receptors antibodies in combination with FDA approved therapeutics to combat efficiently COVID-19. | 2020-10-13 |
| 33046291 | Laboratory indexes provided reliable information on mortality in critically ill patients with COVID-19, which might help improve clinical prediction and treatment at an early stage. | 2020-10-13 |
| 33046293 | The ongoing pandemic of COVID-19 brought to the fore prone positioning as treatment for patients with acute respiratory failure. | 2020-10-13 |
| 33046296 | We retrospectively enrolled 23 and 13 COVID-19 patients who used HFNC and NIV as first-line therapy, respectively. […] Among the 23 patients who used HFNC as first-line therapy, 10 experienced HFNC failure and used NIV as rescue therapy. […] Among the 13 patients who used NIV as first-line therapy, one (8%) used HFNC as rescue therapy due to NIV intolerance. […] 7.3, IQR: 5.3-10.0 days), intubation rate (17% vs. 15%) and mortality (4% vs. 8%) did not differ between patients who used HFNC and NIV as first-line therapy. […] In critically ill patients with COVID-19 who used HFNC and NIV as first-line therapy, the duration of HFNC + NIV, intubation rate and mortality did not differ between two groups. | 2020-10-13 |
| 33046317 | In this work, the survival and mortality data of 54 consecutive patients admitted to the Intensive Care Unit (ICU) and suffering from severe respiratory insufficiency imputable to viral SARS - CoV - 2 infection were analyzed and shared, after a critical review of the evidence in order to optimize the most dedicated clinical and treatment strategy, for a future ‘targeted’ management in the care of the possible return flu outbreak. […] Medical therapy was based on the application of shared protocols. […] All patients received empirical or targeted antibiotic therapy for prevention and control of infections of potential pathogens, together with low molecular weight heparin therapy. […] The majority of patients was subjected to the off - label protocol with antivirals and hydroxychloroquine therapy, we used cortisone support therapy under surveillance and in 3 cases the protocol with anti - IL6 monoclonal antibody (Tolicizumab). […] Mechanical ventilation can adversely affect the prognosis due to lung damage induced, protective ventilation remains the necessary treatment during severe hypoxia in patients with SARS - CoV - 2. […] Further research on this heterogeneous pathology and data sharing could help identify a more dedicated clinical decision-making and treatment pathway that, together with a resource planning, would allow us to better face any new disease outbreak. | 2020-10-13 |
| 33046323 | Moreover, the pooled OR of continuous renal replacement therapy (CRRT) and AKI prevalence for severe vs. non-severe cases was 12.99 (95%CI: 4.03-41.89) and 13.16 (95%CI: 10.16-17.05), respectively. […] AKI is closely related with severity and mortality of COVID-19, which gives awareness for doctors to pay more attention for risk screening, early identification and timely treatment of AKI. | 2020-10-13 |
| 33046353 | Considering that many of our patients already receive antithrombotic or anticoagulant therapy, the fact that they may develop a COVID-19 infection will have implications for the choice, dosage and control of their treatment. | 2020-10-13 |
| 33046370 | In addition, follow-up clinical data including the disease severity, clinical treatment, and clinical outcomes were collected for each patient. […] The AUCs for prediction of ICU treatment and prognosis (partial recovery vs prolonged recovery) were 0.945 and 0.960, respectively. | 2020-10-13 |
| 33046384 | Palliative care emphasizes expertise in handling difficult conversations, discussing patients’ wishes and supporting the caregiver(s). | 2020-10-13 |
| 33046589 | Second, policies regarding the prevention and treatment of COVID-19 may not capture the complexity of the considerations related to pregnancy. | 2020-10-13 |
| 33046686 | Currently, there is no specific treatment for COVID-19 or a vaccine for prevention. | 2020-10-13 |
| 33046850 | As a consequence, treatment strategies are not well established. […] In this Review, we summarize and evaluate the available evidence on the pathogenesis, diagnosis and treatment of myocarditis and inflammatory cardiomyopathy, with a special focus on virus-induced and virus-associated myocarditis. | 2020-10-13 |
| 33047047 | In residential NCH, neither residents nor workers tend to have immediate access to the same expertise, medication and equipment as in hospitals, which exacerbates an already tense situation. | 2020-10-13 |
| 33047062 | Despite several attempts since it emerged, there is no known treatment in the form of drugs or vaccines. | 2020-10-13 |
| 33047098 | Transthoracic echocardiography revealed large right atrial thrombus in transient, resulting in pulmonary embolism and severe RV failure; fibrinolytic therapy was not effective and the patient passed away. | 2020-10-13 |
| 33047161 | Stimulating and preventing the inhibition of the thymus can be possible treatment components against COVID-19. […] • Stimulating and preventing the inhibition of the thymus can be possible treatment components against COVID-19. | 2020-10-13 |
| 33047163 | Patients were risk-stratified using a general medical health composite score (HCS) and a cancer-specific risk (CSR) stratification based on disease and treatment characteristics. | 2020-10-13 |
| 33047223 | There are few reported cases of severe myasthenia crisis following COVID-19, likely due to the involvement of the respiratory apparatus and the use of immunosuppressive medication. | 2020-10-13 |
| 33047335 | We hypothesised that patients who received high-intensity thromboprophylaxis treatment would experience fewer thrombotic events. […] All received some type of thromboprophylaxis treatment except for 6 patients who did not receive any prophylaxis. | 2020-10-13 |
| 33047356 | Therefore, the present article aimed at collecting experiences and recommendations of front-line clinical experts on critical aspects of dental treatment provision during pandemic. […] For aerosol-free and aerosol generating procedures, more than 80% of the experts recommended face protection and caps for every single treatment. | 2020-10-13 |
| 33047493 | After reduction of immunosuppressive therapy, RT-PCR-confirmed COVID-19 transplant patients were able to mount vigorous antiviral T cell and antibody responses, as efficiently as two non-therapeutically immunosuppressed COVID-19 patients on hemodialysis. | 2020-10-13 |
| 33047649 | To explore the changes in the treatment of patients with MBC during COVID-19 pandemic, we promoted a survey to the oncologists operating in the Italian breast units. | 2020-10-13 |
| 33047658 | Our combined studies suggest that the best cysteine focused ligands can help to design an effective lead drug for COVID-19 treatment. | 2020-10-13 |
| 33047711 | Moreover, detection of SARS-CoV-2 nucleic acid by oropharyngeal swabs and IgM, IgG antibodies in the sera of all the health-care workers who participated in the treatment for COVID-19 were all negative. | 2020-10-13 |
| 33047816 | To assess the effectiveness of methods used during dental treatment procedures to minimize aerosol production and reduce or neutralize contamination in aerosols. […] Rubber dam One split-mouth RCT (10 participants) receiving dental treatment, found that there may be a reduction in CFU with rubber dam at one-metre (MD -16.20, 95% CI -19.36 to -13.04) and two-metre distance (MD -11.70, 95% CI -15.82 to -7.58). | 2020-10-13 |
| 33047848 | To assess whether randomized clinical trials (RCTs) proposed to evaluate the treatment of patients with COVID-19 with hydroxychloroquine (HQ) or chloroquine early in the pandemic included plans to measure outcomes that would translate into meaningful efficacy/effectiveness and safety outcomes. | 2020-10-13 |
| 33048028 | As effective medication to treat COVID-19 is currently unavailable, preventive remedies may be particularly important. […] While further confirmation is needed, vitamin D supplementation may have prevention or treatment potential for COVID-19 disease. | 2020-10-13 |
| 33048112 | Prior studies have not examined the association of medication dose with risks. | 2020-10-13 |
| 33048119 | The purpose of this study was to determine whether a uniform infection screening protocol could be used to safely perform head and neck cancer surgery during the coronavirus disease 2019 pandemic and clarify how surgical treatment changed compared with the pre-pandemic period. […] In this study, medical records of 208 patients with head and neck malignancy, who underwent surgical treatment at our hospital during the first and second wave of pandemic for each 2-month period (first wave: 30 March 2020-30 May 2020, second wave: 14 July 2020-14 September 2020) and the 2-month pre-pandemic period (30 October 2019-30 December 2020), were analysed. […] A total of 133 patients were admitted for surgical treatment and all, except six patients with emergency tracheostomy, were screened according to the protocol. […] As a result, all 127 patients received surgical treatment as planned, and all 1247 medical staff members involved in the surgeries were uninfected by severe acute respiratory syndrome coronavirus 2. […] Our data indicate that continuation of head and neck anticancer surgical treatment in an epidemic area during the coronavirus disease 2019 pandemic were safe and feasible, if adequate and strict preventive measures are vigorously and successfully carried out. | 2020-10-13 |
| 33048300 | Itolizumab is a first-in-class anti-CD6 monoclonal antibody that was initially developed for various cancers and was later developed and approved in India for treatment of moderate to severe chronic plaque psoriasis in 2013. […] Based on the results, the Indian drug regulatory agency recently approved itolizumab in July 2020 for ‘restricted emergency use’ for the treatment of CRS in moderate to severe acute respiratory distress syndrome (ARDS) due to COVID-19. […] In a global scenario where finding a successful treatment for COVID-19 is of utmost priority, a biologic agent has been re-purposed and approved with a successfully completed RCT, in a country where cases and mortality due to COVID-19 are growing exponentially. | 2020-10-13 |
| 33048391 | 43.8% described infectious-related symptoms and 15.8% needed an anti-infective treatment. | 2020-10-13 |
| 33048448 | At the time of this writing, there are no available US FDA-approved therapeutics for the treatment of SARS-CoV-2 infection. | 2020-10-13 |
| 33048773 | To counter the outbreak of COVID-19, the accurate diagnosis of suspected cases plays a crucial role in timely quarantine, medical treatment, and preventing the spread of the pandemic. | 2020-10-13 |
| 33048783 | However, our 26% mortality rate was higher than that of the treatment arm of clinical trials comparing plasma with usual treatment, which might be ascribed to higher proportion of patients with MV and septic shock in our cohort. | 2020-10-13 |
| 33048784 | The aim of this study was to describe the impact of these measures on the number of hospitalizations in Cardiovascular Intensive Care Units, with the hypothesis that the social behavior generated by this emergency promotes a decreased demand for medical care, even when severe cardiovascular disease is involved. | 2020-10-13 |
| 33048785 | Fourteen patients required intensive therapy and 6 of them required mechanical ventilation, 4 of them died. | 2020-10-13 |
| 33048786 | We describe type and severity of the adverse events and if treatment suspension was needed. […] The results show a high rate of adverse events (10/23, 43%) in treatment with lopinavir/ritonavir. […] In most cases early treatment suspension was required. | 2020-10-13 |
| 33048801 | The patient evolved favorably upon empirical treatment without requiring invasive maneuvers or ventilatory support. | 2020-10-13 |
| 33048824 | Therefore, the selection of patients for diagnosis and treatment is essential in this situation. | 2020-10-13 |
| 33049215 | In this review, we highlight data at the intersection of COVID-19 and cancer, including the biological interplay between the two diseases and practical recommendations for the treatment of patients with cancer during the pandemic. | 2020-10-13 |
| 33049250 | The objective of this study was to determine the rate of abnormal serum cardiac biomarkers or bradycardia among pregnant and immediately postpartum women admitted for treatment of severe or critical COVID-19 in a large integrated health system in New York. […] Women with a positive PCR test who were admitted for a reason other than treatment of COVID-19 (eg, labor) were excluded. | 2020-10-13 |
| 33049279 | Although numerous antiviral and anti-parasitic drugs are under clinical trials to combat this pandemic, to date, neither a specific treatment nor any successful vaccine has been established, urging researchers to identify any potential candidate for combating the disease. […] Although MSCs-based treatment approaches for COVID-19 is still under consideration with limited data, many human clinical trials of MSC’s has been initiated to explore their potential for COVID 19 treatment. | 2020-10-13 |
| 33049464 | In addition, we found a treatment delay in both intravenous thrombolysis (median 94.5 min versus 38 min) and mechanical thrombectomy (median 244 min versus 86 min) in patients with confirmed COVID-19 infection. […] We observed a reduction of hospital admissions in acute ischemic strokes and some delay in reperfusion therapy during the COVID-19 pandemic. | 2020-10-13 |
| 33049563 | In this review, we propose to highlight the conventional as well as the non-conventional methods for the detection of these inflammatory biomarkers which can act as a single platform of knowledge for the researchers and scientists working for the treatment of COVID-19. | 2020-10-13 |
| 33049573 | Because there is no specific antiviral treatment against COVID-19, new strategies are urgently needed. […] Consequently, we postulate that intravenous selenium therapy, could be part of the therapeutic fight against COVID-19 in intensive care unit patients with ARDS and that outcomes could be affected by age, sex, and body weight. | 2020-10-13 |
| 33049583 | Therefore, ACE2 and TMPRSS2 are potential antiviral targets for treatment of prevention of SARS-CoV-2 infection. […] GB-2 treatment could decrease ACE2 and TMPRSS2 expression level of lung tissue and kidney tissue without adverse effects, including nephrotoxicity and hepatotoxicity, in animal model. | 2020-10-13 |
| 33049594 | Therefore, pathophysiological knowledge about COVID-19 is imperative for better planning of preventive measures, diagnosis, and therapeutics of the disease. […] Based on previous studies, this work proposes new hypothesis related to the role of the renin-angiotensin system on the pathophysiology of COVID-19, and its purpose is to enrich the discussion and to offer alternative ways for experimental and clinical studies aiming at the formulation of new diagnosis and/or treatment methods. | 2020-10-13 |
| 33049695 | Palliative care and oncology providers are posed with unique challenges with the ongoing COVID-19 pandemic. […] Tele-palliative care is the use of tele-health services to deliver palliative care to patients remotely using video conferencing, telephonic communication, or remote symptom monitoring. | 2020-10-13 |
| 33049737 | Here we propose pentoxifylline, a drug with low cost and toxicity, as a possible treatment for COVID-19 in basis of its interesting properties. | 2020-10-13 |
| 33049807 | It lately has received a widespread interest for use as the pulmonary particulate backbone materials of drug carrier for the treatment of infectious disease and cancer. | 2020-10-14 |
| 33050200 | : patients with suspected urgent disease such as medication-related osteonecrosis of the jaws (MRONJ), odontogenic abscesses, temporomandibular joint (TMJ) dislocation, etc.). | 2020-10-14 |
| 33050240 | Studying disease models at the molecular level is vital for drug development in order to improve treatment and prevent a wide range of human pathologies. | 2020-10-14 |
| 33050376 | Some clinical procedures for the management of COVID-19 patients may include extracorporeal membrane oxygenation (ECMO) and renal replacement therapy (CRRT), which also require the use of heparin. […] PF4 and its role in HIT as well as in pathologies seen in COVID-19 patients define a potential therapeutic option of using blocking antibodies in the treatment of COVID-19. | 2020-10-14 |
| 33050487 | There is a deep need for mortality predictors that allow clinicians to quickly triage patients with severe coronavirus disease 2019 (Covid-19) into intensive care units at the time of hospital admission. | 2020-10-14 |
| 33050499 | In this systematic review, we investigate the epidemiology, pathogenesis, risk factors, clinical manifestations, diagnosis and treatment of COVID-19-associated pulmonary aspergillosis (CAPA). | 2020-10-14 |
| 33050601 | Here, we review the current status and future perspectives of biomedical science in the context of COVID-19, including nanotechnology, prevention through vaccine engineering, diagnostic, monitoring, and therapy. | 2020-10-14 |
| 33050727 | In addition, expanding the use of remote Diabetes Self-Management Education and Support (DSMES) and Medical Nutrition Therapy (MNT) services will require new strategies for achieving long-term, effective, continuous, data-driven care. | 2020-10-14 |
| 33050737 | Oxygen is the most commonly used therapy in hospitalized patients with COVID-19. | 2020-10-14 |
| 33050869 | Till date, there exists no effective vaccine or therapy against COVID-19. […] However, with limited clinical data, hydroxychloroquine is being used for treatment and prophylaxis in patients with COVID-19. | 2020-10-14 |
| 33050885 | Anesthesiologists are leading the treatment of COVID-19 patients in 19/28 (68%) Israeli hospitals. | 2020-10-14 |
| 33050900 | The amendment allowed for: at-home dosing of study drug by a healthcare professional, extension of the treatment period by up to 6 months so patients are able to attend an onsite visit to undergo the end-of-treatment bronchoscopy, and replacement of final follow-up visits with a virtual or telephone visit. | 2020-10-14 |
| 33050924 | Participants will be randomly allocated 1:1:1:1:1 to the following strategies: Arm 1: Control arm Arms 2 to 5: Experimental treatment arms Planned interim analyses will be conducted at regular intervals. […] Exclusion criteria are: Inability to make an informed decision to participate (e.g.: dementia, guardianship); Rockwood Clinical Frailty Scale ≥7; Long QT syndrome; QTc interval > 500 ms; Heart rate <50/min; Kalaemia >5.5 mmol/L or <3.5 mmol/L; Ongoing treatment with piperaquine, halofantrine, dasatinib, nilotinib, hydroxyzine, domperidone, citalopram, escitalopram, potent inhibitors or inducers of cytochrome P450 CYP3A4 isoenzyme, repaglinide, azathioprine, 6-mercaptopurine, theophylline, pyrazinamide, warfarin; Known hypersensitivity to any of the trial drugs or to chloroquine and other 4-aminoquinolines, amodiaquine, mefloquine, glafenine, floctafenine, antrafenine, ARB; Hepatic porphyria; Liver failure (Child-Pugh stage ≥B); Stage 4 or 5 chronic kidney disease (GFR <30 mL/min/1.73 m²); Dialysis; Hypersentivity to lactose; Lactase deficiency; Abnormalities in galactose metabolism; Malabsorption syndrome; Glucose-6-phosphate dehydrogenase deficiency; Symptomatic hyperuricemia; Ileus; Colitis; Enterocolitis; Chronic hepatitis B virus disease. […] Randomisation is stratified on ACEI or ARBs treatment at inclusion and on the type of residence (personal home vs. nursing home). | 2020-10-14 |
| 33050945 | Intervention group receives standard pharmacotherapy according to the treatment protocols of the National Committee of COVID-19 and oral famotidine 160 mg (Manufactured by Chemidarou Pharmaceutical Company) four times a day until the day of discharge, for a maximum of fourteen days. […] Comparator group receives standard drug therapy according to the treatment protocols of the National Committee of COVID-19 and placebo in the same dosage. […] Codes in a random sequence are assigned to patients by the treatment team without knowing that each code is in the intervention or comparator group. […] All participants are unaware of which group of this study they are in and after grouping patients in the groups, Patients receive Famotidine in the treatment group and receive a placebo in the control group. | 2020-10-14 |
| 33050947 | Female patients of childbearing potential and fertile male patients who are sexually active with a female of childbearing potential must use highly effective methods of contraception throughout the study and for 1 week following the last dose of study treatment. […] • Known allergy to the study medication • Is on another clinical trial investigating an antiviral treatment for COVID-19 • Pregnancy • Patients with severe hepatic dysfunction equivalent to Grade C in the Child-Pugh classification • Patients with renal impairment requiring dialysis • Is deemed by the Investigator to be ineligible for any reason Participants will be recruited from, and the study visits will take place at Alfred Hospital, Monash Health, Austin Health in Victoria, Australia for hospitalised participants as well as recruitment in the community in participants homes for eligible people not requiring hospitalisation. […] Study participants, study investigators and the study statistician will be blinded to treatment allocation. | 2020-10-14 |
| 33051005 | Thus, timely treatment of diabetic foot ulcers is extremely important. […] However, timely patient treatment during the COVID-19 pandemic is particularly challenging, because of the higher volume of patients and the need to ensure safety of medical personnel. […] This article describes a proposed strategy for diagnosis and treatment of diabetic foot ulcers, based on experiences with infection and control strategies during the COVID-19 pandemic in China. | 2020-10-14 |
| 33051144 | Among the 16 Pt-CSI, 15 received antiviral therapy, 12 received tocilizumab, five underwent methylprednisolone treatment, six received mechanical ventilation, and one died. | 2020-10-14 |
| 33051220 | We sorted medications into glucocorticoids, conventional synthetic disease-modifying antirheumatic drugs (csDMARDs) and biologic or targeted synthetic DMARDs (b/tsDMARDs), which was also divided into monotherapy and b/tsDMARDs-csDMARDs combination therapy. […] Glucocorticoids, csDMARDs and b/tsDMARDs-csDMARDs combination therapy increased the risk of these outcomes, whereas b/tsDMARDs monotherapy, particularly antitumour necrosis factor agents, were associated with a lower risk of hospitalisation and death. | 2020-10-14 |